An analytical method used in determining the identity of a chemical based on its mass using mass analyzers/mass spectrometers.
An indicator of body density as determined by the relationship of BODY WEIGHT to BODY HEIGHT. BMI=weight (kg)/height squared (m2). BMI correlates with body fat (ADIPOSE TISSUE). Their relationship varies with age and gender. For adults, BMI falls into these categories: below 18.5 (underweight); 18.5-24.9 (normal); 25.0-29.9 (overweight); 30.0 and above (obese). (National Center for Health Statistics, Centers for Disease Control and Prevention)
A mass spectrometry technique used for analysis of nonvolatile compounds such as proteins and macromolecules. The technique involves preparing electrically charged droplets from analyte molecules dissolved in solvent. The electrically charged droplets enter a vacuum chamber where the solvent is evaporated. Evaporation of solvent reduces the droplet size, thereby increasing the coulombic repulsion within the droplet. As the charged droplets get smaller, the excess charge within them causes them to disintegrate and release analyte molecules. The volatilized analyte molecules are then analyzed by mass spectrometry.
A mass spectrometry technique using two (MS/MS) or more mass analyzers. With two in tandem, the precursor ions are mass-selected by a first mass analyzer, and focused into a collision region where they are then fragmented into product ions which are then characterized by a second mass analyzer. A variety of techniques are used to separate the compounds, ionize them, and introduce them to the first mass analyzer. For example, for in GC-MS/MS, GAS CHROMATOGRAPHY-MASS SPECTROMETRY is involved in separating relatively small compounds by GAS CHROMATOGRAPHY prior to injecting them into an ionization chamber for the mass selection.
A mass spectrometric technique that is used for the analysis of large biomolecules. Analyte molecules are embedded in an excess matrix of small organic molecules that show a high resonant absorption at the laser wavelength used. The matrix absorbs the laser energy, thus inducing a soft disintegration of the sample-matrix mixture into free (gas phase) matrix and analyte molecules and molecular ions. In general, only molecular ions of the analyte molecules are produced, and almost no fragmentation occurs. This makes the method well suited for molecular weight determinations and mixture analysis.
A procedure consisting of a sequence of algebraic formulas and/or logical steps to calculate or determine a given task.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Chromatographic techniques in which the mobile phase is a liquid.
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
Computer-based representation of physical systems and phenomena such as chemical processes.
Liquid chromatographic techniques which feature high inlet pressures, high sensitivity, and high speed.
The systematic study of the complete complement of proteins (PROTEOME) of organisms.
Elements of limited time intervals, contributing to particular results or situations.
A mass-spectrometric technique that is used for microscopic chemical analysis. A beam of primary ions with an energy of 5-20 kiloelectronvolts (keV) bombards a small spot on the surface of the sample under ultra-high vacuum conditions. Positive and negative secondary ions sputtered from the surface are analyzed in a mass spectrometer in regards to their mass-to-charge ratio. Digital imaging can be generated from the secondary ion beams and their intensity can be measured. Ionic images can be correlated with images from light or other microscopy providing useful tools in the study of molecular and drug actions.
A status with BODY WEIGHT that is grossly above the acceptable or desirable weight, usually due to accumulation of excess FATS in the body. The standards may vary with age, sex, genetic or cultural background. In the BODY MASS INDEX, a BMI greater than 30.0 kg/m2 is considered obese, and a BMI greater than 40.0 kg/m2 is considered morbidly obese (MORBID OBESITY).
The relative amounts of various components in the body, such as percentage of body fat.
Organized periodic procedures performed on large groups of people for the purpose of detecting disease.
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
A microanalytical technique combining mass spectrometry and gas chromatography for the qualitative as well as quantitative determinations of compounds.
The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.
The sum of the weight of all the atoms in a molecule.
A mass spectrometric technique that is used for the analysis of a wide range of biomolecules, such as glycoalkaloids, glycoproteins, polysaccharides, and peptides. Positive and negative fast atom bombardment spectra are recorded on a mass spectrometer fitted with an atom gun with xenon as the customary beam. The mass spectra obtained contain molecular weight recognition as well as sequence information.
Sequential operating programs and data which instruct the functioning of a digital computer.
Theoretical representations that simulate the behavior or activity of biological processes or diseases. For disease models in living animals, DISEASE MODELS, ANIMAL is available. Biological models include the use of mathematical equations, computers, and other electronic equipment.
The protein complement of an organism coded for by its genome.
Statistical formulations or analyses which, when applied to data and found to fit the data, are then used to verify the assumptions and parameters used in the analysis. Examples of statistical models are the linear model, binomial model, polynomial model, two-parameter model, etc.
Systems composed of a computer or computers, peripheral equipment, such as disks, printers, and terminals, and telecommunications capabilities.
Instruments or technological means of communication that reach large numbers of people with a common message: press, radio, television, etc.
Linear POLYPEPTIDES that are synthesized on RIBOSOMES and may be further modified, crosslinked, cleaved, or assembled into complex proteins with several subunits. The specific sequence of AMINO ACIDS determines the shape the polypeptide will take, during PROTEIN FOLDING, and the function of the protein.
An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.
Tomography using x-ray transmission and a computer algorithm to reconstruct the image.
Members of the class of compounds composed of AMINO ACIDS joined together by peptide bonds between adjacent amino acids into linear, branched or cyclical structures. OLIGOPEPTIDES are composed of approximately 2-12 amino acids. Polypeptides are composed of approximately 13 or more amino acids. PROTEINS are linear polypeptides that are normally synthesized on RIBOSOMES.
A noninvasive method for assessing BODY COMPOSITION. It is based on the differential absorption of X-RAYS (or GAMMA RAYS) by different tissues such as bone, fat and other soft tissues. The source of (X-ray or gamma-ray) photon beam is generated either from radioisotopes such as GADOLINIUM 153, IODINE 125, or Americanium 241 which emit GAMMA RAYS in the appropriate range; or from an X-ray tube which produces X-RAYS in the desired range. It is primarily used for quantitating BONE MINERAL CONTENT, especially for the diagnosis of OSTEOPOROSIS, and also in measuring BONE MINERALIZATION.
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
Specialized connective tissue composed of fat cells (ADIPOCYTES). It is the site of stored FATS, usually in the form of TRIGLYCERIDES. In mammals, there are two types of adipose tissue, the WHITE FAT and the BROWN FAT. Their relative distributions vary in different species with most adipose tissue being white.
Determination, by measurement or comparison with a standard, of the correct value of each scale reading on a meter or other measuring instrument; or determination of the settings of a control device that correspond to particular values of voltage, current, frequency or other output.
The statistical reproducibility of measurements (often in a clinical context), including the testing of instrumentation or techniques to obtain reproducible results. The concept includes reproducibility of physiological measurements, which may be used to develop rules to assess probability or prognosis, or response to a stimulus; reproducibility of occurrence of a condition; and reproducibility of experimental results.
Electrophoresis in which a polyacrylamide gel is used as the diffusion medium.
Non-invasive method of demonstrating internal anatomy based on the principle that atomic nuclei in a strong magnetic field absorb pulses of radiofrequency energy and emit them as radiowaves which can be reconstructed into computerized images. The concept includes proton spin tomographic techniques.
The rate dynamics in chemical or physical systems.
The measurement of an organ in volume, mass, or heaviness.
Events that overwhelm the resources of local HOSPITALS and health care providers. They are likely to impose a sustained demand for HEALTH SERVICES rather than the short, intense peak customary with smaller scale disasters.
Theoretical representations that simulate the behavior or activity of systems, processes, or phenomena. They include the use of mathematical equations, computers, and other electronic equipment.
Procedures for finding the mathematical function which best describes the relationship between a dependent variable and one or more independent variables. In linear regression (see LINEAR MODELS) the relationship is constrained to be a straight line and LEAST-SQUARES ANALYSIS is used to determine the best fit. In logistic regression (see LOGISTIC MODELS) the dependent variable is qualitative rather than continuously variable and LIKELIHOOD FUNCTIONS are used to find the best relationship. In multiple regression, the dependent variable is considered to depend on more than a single independent variable.
Statistical models in which the value of a parameter for a given value of a factor is assumed to be equal to a + bx, where a and b are constants. The models predict a linear regression.
The technique that deals with the measurement of the size, weight, and proportions of the human or other primate body.
Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.
Application of statistical procedures to analyze specific observed or assumed facts from a particular study.
Electrophoresis in which a second perpendicular electrophoretic transport is performed on the separate components resulting from the first electrophoresis. This technique is usually performed on polyacrylamide gels.
Theoretical representations that simulate the behavior or activity of genetic processes or phenomena. They include the use of mathematical equations, computers, and other electronic equipment.
A field of biology concerned with the development of techniques for the collection and manipulation of biological data, and the use of such data to make biological discoveries or predictions. This field encompasses all computational methods and theories for solving biological problems including manipulation of models and datasets.
A subtype of striated muscle, attached by TENDONS to the SKELETON. Skeletal muscles are innervated and their movement can be consciously controlled. They are also called voluntary muscles.
The amount of mineral per square centimeter of BONE. This is the definition used in clinical practice. Actual bone density would be expressed in grams per milliliter. It is most frequently measured by X-RAY ABSORPTIOMETRY or TOMOGRAPHY, X RAY COMPUTED. Bone density is an important predictor for OSTEOPOROSIS.
A basis of value established for the measure of quantity, weight, extent or quality, e.g. weight standards, standard solutions, methods, techniques, and procedures used in diagnosis and therapy.
The determination of the pattern of genes expressed at the level of GENETIC TRANSCRIPTION, under specific circumstances or in a specific cell.
Analysis of PEPTIDES that are generated from the digestion or fragmentation of a protein or mixture of PROTEINS, by ELECTROPHORESIS; CHROMATOGRAPHY; or MASS SPECTROMETRY. The resulting peptide fingerprints are analyzed for a variety of purposes including the identification of the proteins in a sample, GENETIC POLYMORPHISMS, patterns of gene expression, and patterns diagnostic for diseases.
Studies in which the presence or absence of disease or other health-related variables are determined in each member of the study population or in a representative sample at one particular time. This contrasts with LONGITUDINAL STUDIES which are followed over a period of time.
Analysis based on the mathematical function first formulated by Jean-Baptiste-Joseph Fourier in 1807. The function, known as the Fourier transform, describes the sinusoidal pattern of any fluctuating pattern in the physical world in terms of its amplitude and its phase. It has broad applications in biomedicine, e.g., analysis of the x-ray crystallography data pivotal in identifying the double helical nature of DNA and in analysis of other molecules, including viruses, and the modified back-projection algorithm universally used in computerized tomography imaging, etc. (From Segen, The Dictionary of Modern Medicine, 1992)
Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
Enlargement of the LEFT VENTRICLE of the heart. This increase in ventricular mass is attributed to sustained abnormal pressure or volume loads and is a contributor to cardiovascular morbidity and mortality.
The location of the atoms, groups or ions relative to one another in a molecule, as well as the number, type and location of covalent bonds.
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
Domesticated bovine animals of the genus Bos, usually kept on a farm or ranch and used for the production of meat or dairy products or for heavy labor.
A multistage process that includes cloning, physical mapping, subcloning, determination of the DNA SEQUENCE, and information analysis.
A variation of the PCR technique in which cDNA is made from RNA via reverse transcription. The resultant cDNA is then amplified using standard PCR protocols.
Studies in which subsets of a defined population are identified. These groups may or may not be exposed to factors hypothesized to influence the probability of the occurrence of a particular disease or other outcome. Cohorts are defined populations which, as a whole, are followed in an attempt to determine distinguishing subgroup characteristics.
Administration of a vaccine to large populations in order to elicit IMMUNITY.
Methods of creating machines and devices.
A statistical technique that isolates and assesses the contributions of categorical independent variables to variation in the mean of a continuous dependent variable.
A technique of inputting two-dimensional images into a computer and then enhancing or analyzing the imagery into a form that is more useful to the human observer.
The insertion of recombinant DNA molecules from prokaryotic and/or eukaryotic sources into a replicating vehicle, such as a plasmid or virus vector, and the introduction of the resultant hybrid molecules into recipient cells without altering the viability of those cells.
The chemical reactions involved in the production and utilization of various forms of energy in cells.
Age as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or the effect of a circumstance. It is used with human or animal concepts but should be differentiated from AGING, a physiological process, and TIME FACTORS which refers only to the passage of time.
Spectroscopic method of measuring the magnetic moment of elementary particles such as atomic nuclei, protons or electrons. It is employed in clinical applications such as NMR Tomography (MAGNETIC RESONANCE IMAGING).
A theorem in probability theory named for Thomas Bayes (1702-1761). In epidemiology, it is used to obtain the probability of disease in a group of people with some characteristic on the basis of the overall rate of that disease and of the likelihood of that characteristic in healthy and diseased individuals. The most familiar application is in clinical decision analysis where it is used for estimating the probability of a particular diagnosis given the appearance of some symptoms or test result.
Methods used for detecting the amplified DNA products from the polymerase chain reaction as they accumulate instead of at the end of the reaction.
Collective behavior of an aggregate of individuals giving the appearance of unity of attitude, feeling, and motivation.
In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.
Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.
The arrangement of two or more amino acid or base sequences from an organism or organisms in such a way as to align areas of the sequences sharing common properties. The degree of relatedness or homology between the sequences is predicted computationally or statistically based on weights assigned to the elements aligned between the sequences. This in turn can serve as a potential indicator of the genetic relatedness between the organisms.
Partial proteins formed by partial hydrolysis of complete proteins or generated through PROTEIN ENGINEERING techniques.
An atom or group of atoms that have a positive or negative electric charge due to a gain (negative charge) or loss (positive charge) of one or more electrons. Atoms with a positive charge are known as CATIONS; those with a negative charge are ANIONS.
In INFORMATION RETRIEVAL, machine-sensing or identification of visible patterns (shapes, forms, and configurations). (Harrod's Librarians' Glossary, 7th ed)
A specialized CONNECTIVE TISSUE that is the main constituent of the SKELETON. The principle cellular component of bone is comprised of OSTEOBLASTS; OSTEOCYTES; and OSTEOCLASTS, while FIBRILLAR COLLAGENS and hydroxyapatite crystals form the BONE MATRIX.
Maleness or femaleness as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or effect of a circumstance. It is used with human or animal concepts but should be differentiated from SEX CHARACTERISTICS, anatomical or physiological manifestations of sex, and from SEX DISTRIBUTION, the number of males and females in given circumstances.
Techniques for labeling a substance with a stable or radioactive isotope. It is not used for articles involving labeled substances unless the methods of labeling are substantively discussed. Tracers that may be labeled include chemical substances, cells, or microorganisms.
Proteins prepared by recombinant DNA technology.
Studies which start with the identification of persons with a disease of interest and a control (comparison, referent) group without the disease. The relationship of an attribute to the disease is examined by comparing diseased and non-diseased persons with regard to the frequency or levels of the attribute in each group.
A status with BODY WEIGHT that is above certain standard of acceptable or desirable weight. In the scale of BODY MASS INDEX, overweight is defined as having a BMI of 25.0-29.9 kg/m2. Overweight may or may not be due to increases in body fat (ADIPOSE TISSUE), hence overweight does not equal "over fat".
The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments.
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
The degree of similarity between sequences of amino acids. This information is useful for the analyzing genetic relatedness of proteins and species.
The process of generating three-dimensional images by electronic, photographic, or other methods. For example, three-dimensional images can be generated by assembling multiple tomographic images with the aid of a computer, while photographic 3-D images (HOLOGRAPHY) can be made by exposing film to the interference pattern created when two laser light sources shine on an object.
A species of gram-negative, facultatively anaerobic, rod-shaped bacteria (GRAM-NEGATIVE FACULTATIVELY ANAEROBIC RODS) commonly found in the lower part of the intestine of warm-blooded animals. It is usually nonpathogenic, but some strains are known to produce DIARRHEA and pyogenic infections. Pathogenic strains (virotypes) are classified by their specific pathogenic mechanisms such as toxins (ENTEROTOXIGENIC ESCHERICHIA COLI), etc.
The range or frequency distribution of a measurement in a population (of organisms, organs or things) that has not been selected for the presence of disease or abnormality.
The physical characteristics of the body, including the mode of performance of functions, the activity of metabolic processes, the manner and degree of reactions to stimuli, and power of resistance to the attack of pathogenic organisms.
The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.
The physical measurements of a body.
The amount of fat or lipid deposit at a site or an organ in the body, an indicator of body fat status.
In screening and diagnostic tests, the probability that a person with a positive test is a true positive (i.e., has the disease), is referred to as the predictive value of a positive test; whereas, the predictive value of a negative test is the probability that the person with a negative test does not have the disease. Predictive value is related to the sensitivity and specificity of the test.
The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
Hybridization of a nucleic acid sample to a very large set of OLIGONUCLEOTIDE PROBES, which have been attached individually in columns and rows to a solid support, to determine a BASE SEQUENCE, or to detect variations in a gene sequence, GENE EXPRESSION, or for GENE MAPPING.
The distance from the sole to the crown of the head with body standing on a flat surface and fully extended.
The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM.
A process that includes the determination of AMINO ACID SEQUENCE of a protein (or peptide, oligopeptide or peptide fragment) and the information analysis of the sequence.
A set of statistical methods used to group variables or observations into strongly inter-related subgroups. In epidemiology, it may be used to analyze a closely grouped series of events or cases of disease or other health-related phenomenon with well-defined distribution patterns in relation to time or place or both.
The property of objects that determines the direction of heat flow when they are placed in direct thermal contact. The temperature is the energy of microscopic motions (vibrational and translational) of the particles of atoms.
A characteristic feature of enzyme activity in relation to the kind of substrate on which the enzyme or catalytic molecule reacts.
The total number of cases of a given disease in a specified population at a designated time. It is differentiated from INCIDENCE, which refers to the number of new cases in the population at a given time.
A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.
A state of insufficient flesh on the body usually defined as having a body weight less than skeletal and physical standards. Depending on age, sex, and genetic background, a BODY MASS INDEX of less than 18.5 is considered as underweight.
A 51-amino acid pancreatic hormone that plays a major role in the regulation of glucose metabolism, directly by suppressing endogenous glucose production (GLYCOGENOLYSIS; GLUCONEOGENESIS) and indirectly by suppressing GLUCAGON secretion and LIPOLYSIS. Native insulin is a globular protein comprised of a zinc-coordinated hexamer. Each insulin monomer containing two chains, A (21 residues) and B (30 residues), linked by two disulfide bonds. Insulin is used as a drug to control insulin-dependent diabetes mellitus (DIABETES MELLITUS, TYPE 1).
The genetic constitution of the individual, comprising the ALLELES present at each GENETIC LOCUS.
Computer-assisted processing of electric, ultrasonic, or electronic signals to interpret function and activity.
The normality of a solution with respect to HYDROGEN ions; H+. It is related to acidity measurements in most cases by pH = log 1/2[1/(H+)], where (H+) is the hydrogen ion concentration in gram equivalents per liter of solution. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)
The portion of an interactive computer program that issues messages to and receives commands from a user.
The properties, processes, and behavior of biological systems under the action of mechanical forces.
Concentration or quantity that is derived from the smallest measure that can be detected with reasonable certainty for a given analytical procedure.
Physical activity which is usually regular and done with the intention of improving or maintaining PHYSICAL FITNESS or HEALTH. Contrast with PHYSICAL EXERTION which is concerned largely with the physiologic and metabolic response to energy expenditure.
Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
Established cell cultures that have the potential to propagate indefinitely.
Proteins found in any species of bacterium.
Glucose in blood.
A generic term for fats and lipoids, the alcohol-ether-soluble constituents of protoplasm, which are insoluble in water. They comprise the fats, fatty oils, essential oils, waxes, phospholipids, glycolipids, sulfolipids, aminolipids, chromolipids (lipochromes), and fatty acids. (Grant & Hackh's Chemical Dictionary, 5th ed)
Chromatography on non-ionic gels without regard to the mechanism of solute discrimination.
Any visible result of a procedure which is caused by the procedure itself and not by the entity being analyzed. Common examples include histological structures introduced by tissue processing, radiographic images of structures that are not naturally present in living tissue, and products of chemical reactions that occur during analysis.
Any of a variety of procedures which use biomolecular probes to measure the presence or concentration of biological molecules, biological structures, microorganisms, etc., by translating a biochemical interaction at the probe surface into a quantifiable physical signal.
The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION.
The vapor state of matter; nonelastic fluids in which the molecules are in free movement and their mean positions far apart. Gases tend to expand indefinitely, to diffuse and mix readily with other gases, to have definite relations of volume, temperature, and pressure, and to condense or liquefy at low temperatures or under sufficient pressure. (Grant & Hackh's Chemical Dictionary, 5th ed)
Theory and development of COMPUTER SYSTEMS which perform tasks that normally require human intelligence. Such tasks may include speech recognition, LEARNING; VISUAL PERCEPTION; MATHEMATICAL COMPUTING; reasoning, PROBLEM SOLVING, DECISION-MAKING, and translation of language.
A research technique to measure solvent exposed regions of molecules that is used to provide insight about PROTEIN CONFORMATION.
The restriction of a characteristic behavior, anatomical structure or physical system, such as immune response; metabolic response, or gene or gene variant to the members of one species. It refers to that property which differentiates one species from another but it is also used for phylogenetic levels higher or lower than the species.
Diseases of the uterine appendages (ADNEXA UTERI) including diseases involving the OVARY, the FALLOPIAN TUBES, and ligaments of the uterus (BROAD LIGAMENT; ROUND LIGAMENT).
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.
Separation technique in which the stationary phase consists of ion exchange resins. The resins contain loosely held small ions that easily exchange places with other small ions of like charge present in solutions washed over the resins.
Ultrasonic recording of the size, motion, and composition of the heart and surrounding tissues. The standard approach is transthoracic.
A deoxyribonucleotide polymer that is the primary genetic material of all cells. Eukaryotic and prokaryotic organisms normally contain DNA in a double-stranded state, yet several important biological processes transiently involve single-stranded regions. DNA, which consists of a polysugar-phosphate backbone possessing projections of purines (adenine and guanine) and pyrimidines (thymine and cytosine), forms a double helix that is held together by hydrogen bonds between these purines and pyrimidines (adenine to thymine and guanine to cytosine).
Decrease in existing BODY WEIGHT.
Organic compounds that generally contain an amino (-NH2) and a carboxyl (-COOH) group. Twenty alpha-amino acids are the subunits which are polymerized to form proteins.
A chemical reaction in which an electron is transferred from one molecule to another. The electron-donating molecule is the reducing agent or reductant; the electron-accepting molecule is the oxidizing agent or oxidant. Reducing and oxidizing agents function as conjugate reductant-oxidant pairs or redox pairs (Lehninger, Principles of Biochemistry, 1982, p471).
Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.
Heat production, or its measurement, of an organism at the lowest level of cell chemistry in an inactive, awake, fasting state. It may be determined directly by means of a calorimeter or indirectly by calculating the heat production from an analysis of the end products of oxidation within the organism or from the amount of oxygen utilized.
The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment.
Models used experimentally or theoretically to study molecular shape, electronic properties, or interactions; includes analogous molecules, computer-generated graphics, and mechanical structures.
The resistance to the flow of either alternating or direct electrical current.
Predetermined sets of questions used to collect data - clinical data, social status, occupational group, etc. The term is often applied to a self-completed survey instrument.
Devices for accelerating charged particles in a spiral path by a constant-frequency alternating electric field. This electric field is synchronized with the movement of the particles in a constant magnetic field.
Studies in which variables relating to an individual or group of individuals are assessed over a period of time.
The systematic identification and quantitation of all the metabolic products of a cell, tissue, organ, or organism under varying conditions. The METABOLOME of a cell or organism is a dynamic collection of metabolites which represent its net response to current conditions.
Theoretical representations that simulate the behavior or activity of chemical processes or phenomena; includes the use of mathematical equations, computers, and other electronic equipment.
The evaluation of incidents involving the loss of function of a device. These evaluations are used for a variety of purposes such as to determine the failure rates, the causes of failures, costs of failures, and the reliability and maintainability of devices.
Substances used for the detection, identification, analysis, etc. of chemical, biological, or pathologic processes or conditions. Indicators are substances that change in physical appearance, e.g., color, at or approaching the endpoint of a chemical titration, e.g., on the passage between acidity and alkalinity. Reagents are substances used for the detection or determination of another substance by chemical or microscopical means, especially analysis. Types of reagents are precipitants, solvents, oxidizers, reducers, fluxes, and colorimetric reagents. (From Grant & Hackh's Chemical Dictionary, 5th ed, p301, p499)
The sequence of carbohydrates within POLYSACCHARIDES; GLYCOPROTEINS; and GLYCOLIPIDS.
Any of various enzymatically catalyzed post-translational modifications of PEPTIDES or PROTEINS in the cell of origin. These modifications include carboxylation; HYDROXYLATION; ACETYLATION; PHOSPHORYLATION; METHYLATION; GLYCOSYLATION; ubiquitination; oxidation; proteolysis; and crosslinking and result in changes in molecular weight and electrophoretic motility.
The relationships of groups of organisms as reflected by their genetic makeup.
Regular course of eating and drinking adopted by a person or animal.
Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.
The development and use of techniques to study physical phenomena and construct structures in the nanoscale size range or smaller.
The qualitative or quantitative estimation of the likelihood of adverse effects that may result from exposure to specified health hazards or from the absence of beneficial influences. (Last, Dictionary of Epidemiology, 1988)
A serine endopeptidase that is formed from TRYPSINOGEN in the pancreas. It is converted into its active form by ENTEROPEPTIDASE in the small intestine. It catalyzes hydrolysis of the carboxyl group of either arginine or lysine. EC
Deuterium. The stable isotope of hydrogen. It has one neutron and one proton in the nucleus.
A chromatographic technique that utilizes the ability of biological molecules to bind to certain ligands specifically and reversibly. It is used in protein biochemistry. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
Extensive collections, reputedly complete, of facts and data garnered from material of a specialized subject area and made available for analysis and application. The collection can be automated by various contemporary methods for retrieval. The concept should be differentiated from DATABASES, BIBLIOGRAPHIC which is restricted to collections of bibliographic references.
The characteristic 3-dimensional shape of a protein, including the secondary, supersecondary (motifs), tertiary (domains) and quaternary structure of the peptide chain. PROTEIN STRUCTURE, QUATERNARY describes the conformation assumed by multimeric proteins (aggregates of more than one polypeptide chain).
The science and art of collecting, summarizing, and analyzing data that are subject to random variation. The term is also applied to the data themselves and to the summarization of the data.
The lower right and left chambers of the heart. The right ventricle pumps venous BLOOD into the LUNGS and the left ventricle pumps oxygenated blood into the systemic arterial circulation.
Functions constructed from a statistical model and a set of observed data which give the probability of that data for various values of the unknown model parameters. Those parameter values that maximize the probability are the maximum likelihood estimates of the parameters.
Any of various animals that constitute the family Suidae and comprise stout-bodied, short-legged omnivorous mammals with thick skin, usually covered with coarse bristles, a rather long mobile snout, and small tail. Included are the genera Babyrousa, Phacochoerus (wart hogs), and Sus, the latter containing the domestic pig (see SUS SCROFA).
The parts of a macromolecule that directly participate in its specific combination with another molecule.
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control (induction or repression) of gene action at the level of transcription or translation.
Histochemical localization of immunoreactive substances using labeled antibodies as reagents.
Increase in BODY WEIGHT over existing weight.
The chemical or biochemical addition of carbohydrate or glycosyl groups to other chemicals, especially peptides or proteins. Glycosyl transferases are used in this biochemical reaction.
The misinterpretation of a real external, sensory experience.
A single nucleotide variation in a genetic sequence that occurs at appreciable frequency in the population.
A 16-kDa peptide hormone secreted from WHITE ADIPOCYTES. Leptin serves as a feedback signal from fat cells to the CENTRAL NERVOUS SYSTEM in regulation of food intake, energy balance, and fat storage.
Single-stranded complementary DNA synthesized from an RNA template by the action of RNA-dependent DNA polymerase. cDNA (i.e., complementary DNA, not circular DNA, not C-DNA) is used in a variety of molecular cloning experiments as well as serving as a specific hybridization probe.
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
Continuous frequency distribution of infinite range. Its properties are as follows: 1, continuous, symmetrical distribution with both tails extending to infinity; 2, arithmetic mean, mode, and median identical; and 3, shape completely determined by the mean and standard deviation.
Improvement of the quality of a picture by various techniques, including computer processing, digital filtering, echocardiographic techniques, light and ultrastructural MICROSCOPY, fluorescence spectrometry and microscopy, scintigraphy, and in vitro image processing at the molecular level.
Progressive decline in muscle mass due to aging which results in decreased functional capacity of muscles.
A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.
The process of cleaving a chemical compound by the addition of a molecule of water.
Microscopy of specimens stained with fluorescent dye (usually fluorescein isothiocyanate) or of naturally fluorescent materials, which emit light when exposed to ultraviolet or blue light. Immunofluorescence microscopy utilizes antibodies that are labeled with fluorescent dye.
Statistical models which describe the relationship between a qualitative dependent variable (that is, one which can take only certain discrete values, such as the presence or absence of a disease) and an independent variable. A common application is in epidemiology for estimating an individual's risk (probability of a disease) as a function of a given risk factor.
Short sequences (generally about 10 base pairs) of DNA that are complementary to sequences of messenger RNA and allow reverse transcriptases to start copying the adjacent sequences of mRNA. Primers are used extensively in genetic and molecular biology techniques.
Databases containing information about PROTEINS such as AMINO ACID SEQUENCE; PROTEIN CONFORMATION; and other properties.
Mathematical procedure that transforms a number of possibly correlated variables into a smaller number of uncorrelated variables called principal components.
A clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
An infant during the first month after birth.
The monitoring of the level of toxins, chemical pollutants, microbial contaminants, or other harmful substances in the environment (soil, air, and water), workplace, or in the bodies of people and animals present in that environment.
Those characteristics that distinguish one SEX from the other. The primary sex characteristics are the OVARIES and TESTES and their related hormones. Secondary sex characteristics are those which are masculine or feminine but not directly related to reproduction.
A principle of estimation in which the estimates of a set of parameters in a statistical model are those quantities minimizing the sum of squared differences between the observed values of a dependent variable and the values predicted by the model.
A graphic means for assessing the ability of a screening test to discriminate between healthy and diseased persons; may also be used in other studies, e.g., distinguishing stimuli responses as to a faint stimuli or nonstimuli.
Total number of calories taken in daily whether ingested or by parenteral routes.
Tumors or cancer of the human BREAST.
The measurement of subcutaneous fat located directly beneath the skin by grasping a fold of skin and subcutaneous fat between the thumb and forefinger and pulling it away from the underlying muscle tissue. The thickness of the double layer of skin and subcutaneous tissue is then read with a caliper. The five most frequently measured sites are the upper arm, below the scapula, above the hip bone, the abdomen, and the thigh. Its application is the determination of relative fatness, of changes in physical conditioning programs, and of the percentage of body fat in desirable body weight. (From McArdle, et al., Exercise Physiology, 2d ed, p496-8)
Morgan, Jillian (21 February 2020). "Amazon Studios acquires Garrett Bradley Sundance doc "Time"". Real Screen. Retrieved 13 ... Ehrlich, David (3 February 2020). "'Time' Review: A Poignant and Monumental Portrait of Mass Incarceration in America". ... It also screened at the New York Film Festival on September 20, 2020. It was released theatrically on October 9, 2020, and on ... Film Independent Spirit Awards: 'Never Rarely Sometimes Always,' 'Minari,' 'Ma Rainey's Black Bottom,' 'Nomadland' Top ...
Half-Real: Video Games between Real Rules and Fictional Worlds. Cambridge, Massachusetts: MIT Press. 2005. ISBN 978-0262101103 ... Cambridge, Massachusetts: MIT Press. 2013. ISBN 978-0262019057. Nina C. Ayoub. "Screen Spleen." The Chronicle Review, March 18 ... Juul's book on video game theory, Half-Real: Video Games Between Real Rules and Fictional Worlds was published by MIT Press in ... CS1 maint: discouraged parameter (link) "Video Games between Real Rules and Fictional Worlds". Half-Real. Retrieved 2011-10-03 ...
In January 2015, Sussex Police began a voluntary mass DNA screening programme in Bosham, asking men aged 17 and over to give ... a real-life Midsomer". The Independent. Retrieved 9 March 2017. CS1 maint: discouraged parameter (link) Press Association (21 ... mass DNA screening to begin in Bosham". The Guardian. Retrieved 9 March 2017. CS1 maint: discouraged parameter (link) "Valerie ...
Wisconsin and Massachusetts (as of February 1, 2009) screen newborns for SCID. Michigan began screening for SCID in October ... All states in the U.S. are performing screening for SCID in newborns using real-time quantitative PCR to measure the ... "National Newborn Screening Status Report" (PDF). "Wisconsin First State in Nation to Screen All Newborns for Severe Combined ... "Newborn Screening for Primary Immunodeficiency Disease". Yee A, De Ravin SS, Elliott E, Ziegler JB (2008). "Severe combined ...
2020). "Pooling Upper Respiratory Specimens for Rapid Mass Screening of COVID-19 by Real-Time RT-PCR". Emerg Infect Dis. 26 (10 ... "Vigo opens the new laboratory for COVID-19 screening by pooling". La Voz de Galicia. 26 September 2020. Retrieved 30 November ... "Swab pooling for large-scale RT-qPCR screening of SARS-CoV-2" (PDF). medRxiv. 5 September 2020. doi:10.1101/2020.09.03.20187732 ... 2020). "A novel strategy for community screening of SARS-CoV-2 (COVID-19): Sample pooling method". PLOS ONE. 15 (8): e0238417. ...
There was no real ground connection to the antenna, and the screen created an artificial grounding system, limiting the ... The station's first location was at the corner of North Main Street and Central Street in Fall River, Massachusetts, known as ... The studios have moved to Home Street in Somerset, Massachusetts as WHTB and WSAR are still owned by the Karams. "WALE ... WHTB (1400 AM) is a Portuguese language radio station in Fall River, Massachusetts, operating with 1 kW unlimited hours. ...
... "elite who study things and get to say what is or is not real". During the interview, Colbert showed a sentence on the screen, " ... In May 2006, the Tom DeLay Legal Defense Trust posted a video of The Colbert Report on its website and sent out a mass email ... Colbert report#Green Screen Challenge "Stephen Colbert Officially Announces Run for White House!". October 16, 2007. Archived ... On July 30, 2008, Colbert apologized for the story, insisting that he was incorrect and that the real crappy Canton was Canton ...
Rouner, Jeff (December 4, 2013). "Real Horror: Local Filmmaker Brings the Horrific Crimes of Dean Corll to the Silver Screen". ... A film loosely inspired by the Houston Mass Murders, Freak Out, was released in 2003. The film was directed by Brad Jones, who ... The crimes, which became known as the Houston Mass Murders, came to light after Henley fatally shot Corll. Many of the victims ... At the time of their discovery, the Houston Mass Murders were considered the worst example of serial murder in American history ...
MA Khan, Screen India, 21 November 2003. Behind the curtain: making music in Mumbai's film studios, Gregory D. Booth, 2008 ... "We arrangers did all the real work. They'd show off to the directors and producers and try to show that they were indispensable ... Retrieved 25 June 2011.CS1 maint: archived copy as title (link) The 'Real' Anthony Gonsalves! Archived 23 December 2007 at the ...
CS1 maint: discouraged parameter (link) The 'Real' Anthony Gonsalves! Archived 23 December 2007 at the Wayback Machine, MA Khan ... Screen India, 21 November 2003. Remembering Anthony Gonsalves, Naresh Fernandes (Time Out editor), India Seminar No. 543, ...
... unsuitable for screening on public holidays. It went on mass release on 3 February 1961, but there was no premiere. Commentary ... Interiors were filmed at Real Film's Wandsbek Studios in Hamburg, four later films from the series were also shot there. ...
Turing tested the code in a game in 1952 where he mimicked the operation of the code in a real chess game against an opponent, ... As a part of a thesis on human-computer interaction, Douglas used one of these screens to portray other information to the user ... was a simulation of a bouncing ball created by Massachusetts Institute of Technology (MIT) student Oliver Aberth for the ... Their move would appear on the screen, and then the computer's move would follow. The game was not available to the general ...
A mass spectroscope is similar to a mass spectrograph except that the beam of ions is directed onto a phosphor screen. A mass ... Direct Analysis in Real Time (DART), atmospheric pressure chemical ionization (APCI), secondary ion mass spectrometry (SIMS), ... Analysis of mass spectra can also be spectra with accurate mass. A mass-to-charge ratio value (m/z) with only integer precision ... Many mass spectrometers use two or more mass analyzers for tandem mass spectrometry (MS/MS). In addition to the more common ...
Screen Rant's Marian Phillips used the term "cancel culture" to describe this situation. Mullane wrote that Jo Powers was a " ... Leane found that similar bee technologies had been piloted in the real world, including the RoboBee, which is designed for ... A ticker announces the MASS technology from "Men Against Fire". Another reports on a technology from "White Christmas"-cookies- ... Allusions are made to previous episodes, largely through news tickers and trending topics on displayed social media screens. ...
The real-time video editing platform is used by the NHL, Sky Sports, the Brit Awards, Wimbledon, FIFA World Cup, Channel 5, ATP ... Companies like Mass Relevance, TV Interact and Vidpresso all aim to help broadcasters more easily use social media. ... A show's hashtag is usually placed on the lower corners of the screen during new airings of the show in order to help guide ... A plan for increasing Internet traffic related to a single show is the placement of hashtags on the screen during dramatic ...
Mendiburu, Bernard (2009). 3D Movie Making: Stereoscopic Digital Cinema from Script to Screen. Burlington, Massachusetts: Focal ... We all see in 3D in real life and every technological advancement in film has always been about bringing you closer and ... In 2008, it earned three awards, including "Best Film Produced Non-Exclusively for the Giant Screen" at the Giant Screen Cinema ... "the most high tech film screening that's ever been done in history." U2 3D was slated to be screened only in IMAX theaters, but ...
"Top Chef, Real Housewives head to Thailand". Michelle Clancy. December 9, 2016. Retrieved April 8, 2017. Valdez, Maria G. ( ... "Top Chef launches in SA". Screen Africa. July 6, 2016. Retrieved July 7, 2016. "Chicote da el gran salto a Antena 3 con 'Top ... Gwiazdy od kuchni". Największy krytyk kulinarny Tomasza Oświecińskiego ma... 6 lat! [WIDEO+ZDJĘCIA]". Telemagazyn (in Polish). ...
It is based on a real 1926 case in Magdeburg. Hans Christian Blech as Karlheinz Gabler Ernst Waldow as Kriminalkommissar ... Bosley Crowther (October 18, 1949). "The Screen; German Drama at World". The New York Times. List of the 50 highest-grossing ... "The Blum Affair (Affaire Blum): Synopsis". DEFA Film Library, University of Massachusetts Amherst. Retrieved 25 May 2015. ...
... weapons of mass destruction and parallel worlds. The director said about the movie, after its screening at the Berlin Festival ... The concept of this division into real and surreal is that in the first part, the main topic is peace. For me it is important ... When the actor Mohammed Reza Golzar appears, the film changes from the real to the surreal. ... and screened at the 65th Berlin International Film Festival, the 16th San Diego Asian Film Festival and the Zurich Film ...
Colorado mass shooting occurred during a screening of The Dark Knight Rises refused to show it. Despite this, Joker became a ... She says of Arthur and others in poverty who have mental illness: "We as a society don't even pretend that they're real people ... Colorado movie theater where the 2012 mass shooting occurred during a screening of The Dark Knight Rises. Three families of ... It also screened at the Toronto International Film Festival on September 9, 2019. The film was released theatrically by Warner ...
We screen men for the possibility of committing mass shootings or terrorist attacks. The base rate is assumed to be 0.01%. With ... which is likely to be higher than most real-world tests. We can examine several scenarios to see how well this hypothetical ... The efficacy of screening tests can be analyzed using Bayes' theorem. Suppose that there is some binary screening procedure for ... For any screening test, we must be cognizant of its sensitivity and specificity. The screening test has sensitivity P ( + , V ...
The existing small Ma & Pa Kettle Petting Zoo was expanded into the Ark Park. This area encompassed the Mt. Ararat petting zoo ... In 1968, the Screen Actors Guild enacted a rule prohibiting visitors from most soundstages. This new rule, coupled with more ... Its official marketing headline is "The Entertainment Capital of LA". It was initially created to offer tours of the real ... "BREAKING NEWS: "Jurassic World-The Ride" Opens at Universal Studios Hollywood and It Just Got Real". NBCUniversal MediaVillage ...
"Applications of ambient mass spectrometry in high-throughput screening". The Analyst. 138 (11): 3097-103. Bibcode:2013Ana... ... With the aid of DART, exact mass measurements can be done rapidly with high-resolution mass spectrometers. DART mass ... "Determination of drugs and drug-like compounds in different samples with direct analysis in real time mass spectrometry". Mass ... "Dopant-assisted direct analysis in real time mass spectrometry with argon gas". Rapid Communications in Mass Spectrometry. 30 ( ...
2007). Real-Time PCR in Microbiology: From Diagnosis to Characterization. Caister Academic Press. ISBN 978-1-904455-18-9. ... ISBN 978-1-55581-371-0. Tacconelli E, De Angelis G, de Waure C, Cataldo MA, La Torre G, Cauda R (September 2009). "Rapid ... Mathematical models describe one way in which a loss of infection control can occur after measures for screening and isolation ... Tacconelli E, De Angelis G, Cataldo MA, Pozzi E, Cauda R (January 2008). "Does antibiotic exposure increase the risk of ...
Because of such interest in mass media and blogosphere, lots of series fans discovered this story, and "Nuclear Gandhi" became ... ISBN 978-1-324-00587-2. Dustin Bailey (2020-09-08). "Sid Meier says Civilization's nuclear Gandhi bug isn't real". PCGamesN. ... Screen Rant. Retrieved 2020-09-18. CS1 maint: discouraged parameter (link) Алексей Афанасьев (2020-09-16). "История появления ... India and weapons of mass destruction Smiling Buddha Ethan Maurice (2020-06-30). "Why Gandhi Is So Violent In Civilization ...
Athadu - All the scenes' location and time appears in the typical Athadu style at the bottom of the screen. Eg: Time ... As compared to the opposite condition in the original movie.) Pokiri - the hero's real identity being that of a police officer ... vaachipoyindi, Gabbar Singh release ayyi collections tsunami srusthistunna time lo.. Mass- another attempt of the hero to ... According to trade analyst Taran Adarsh, the film has taken Rs 2,455,000 ($44,255) from its screening in the country on ...
Boas MA (1927). "The Effect of Desiccation upon the Nutritive Properties of Egg-white". Biochem. J. 21 (3): 712-724.1. doi: ... László A, Schuler EA, Sallay E, Endreffy E, Somogyi C, Várkonyi A, Havass Z, Jansen KP, Wolf B (2003). "Neonatal screening for ... Dobrowolski SF, Angeletti J, Banas RA, Naylor EW (February 2003). "Real time PCR assays to detect common mutations in the ... relevance of newborn screening". Dev Med Child Neurol. 46 (7): 481-4. doi:10.1111/j.1469-8749.2004.tb00509.x. PMID 15230462. ...
The information would be available on the MBTA website, E Ink screens, and in the Transit app. At conception the service is was ... In June 2020 in the aftermath of COVID-19 pandemic, the MBTA had begun providing real-time information on crowding. ... "Famous Firsts in Massachusetts". Commonwealth of Massachusetts. Archived from the original on February 8, 2007. Retrieved ... "Massachusetts Bay Transit Authority, Regional Transit Authorities Coordination and Efficiencies Report" (PDF). Massachusetts ...
... one had the screen divided into two parts, one for each player. The turns were also divided into move and attack ... Battle Isle: The Andosian War was entirely set in the 3-D environment and combined elements of real-time and turn-based ... The AI is relatively weak, relying on mass frontal assaults. After a player survives the first few turns and the AI's ... Battle Isle 2 gave the player the entire screen, and merged move and attack phases, and introduced the 3-D display of combat. ...
However, classic effects with an apparent 3D look often have no real-time 3D calculation whatsoever. For example, static screen ... Before the advent of mass-marketed 3D acceleration hardware, democoders often focused on lighting and shading techniques in ... to allow for more demanding real-time calculations) became common. Effects based on static screen-to-texture lookup tables ... Demo effect is computer-based real-time visual effects found in demos created by the demoscene. The main purpose of demo ...
Olivero J, Fa JE, Real R, Márquez AL, Farfán MA, Vargas JM, et al. (30 October 2017). "Recent loss of closed forests is ... Virus persistence in semen for over a year has been recorded in a national screening programme.[64] Ebola may also occur in the ... Choi JH, Croyle MA (December 2013). "Emerging targets and novel approaches to Ebola virus prophylaxis and treatment". BioDrugs ... In field or mobile hospitals, the most common and sensitive diagnostic methods are real-time PCR and ELISA.[99] In 2014, with ...
a b Massachusetts (State). Legislature. General Court. 1887 Chap. 0183. An Act to Secure Proper Sanitary Provisions in ... The re-labelling of existing multi-cubicle public toilets, with no real change. For example, this approach was taken in one ... One option would be to continue to offer urinals in rows, with separation by screens. However, it is questionable whether the ... the Massachusetts statute was definitely not the first law mandating sex-separation in Massachusetts. ...
The original video contained no title screen and was roughly edited. The video featured a medley of footage from Success-N-Life ... Tilton was particularly influenced by Dave Del Dotto, a real estate promoter who produced hour-long infomercials showing his ... the Tulsa-based marketing firm handling Tilton's mass mailings, to discuss a proposal sent by Anthony to Response Media about ...
325,000 from 481 IMAX screens and premium large-format screens from late night showings, which began at 7 pm,[41][42] and an ... Brad Brevet (20 September 2015). "'Maze' and 'Mass' Top Box Office, but 'Everest' and 'Sicario' are the Story". Box Office Mojo ... It is based on the real events of the 1996 Mount Everest disaster, and focuses on the survival attempts of two expedition ... Screen Actors Guild Awards[59] Outstanding Performance by a Stunt Ensemble in a Motion Picture Nominated ...
Niebuhr argued this approach was a pious way to refuse to face real problems.[65] ... that former FBI director James Comey used Niebuhr's name as a screen name for his personal Twitter account. Comey, as a ... Stockbridge, Massachusetts, U.S.. Education. Elmhurst College. Eden Theological Seminary. Yale Divinity School. ...
Current mass extinction". In Elewa, Ashraf M. T. (ed.). Mass Extinction. pp. 191-194. doi:10.1007/978-3-540-75916-4_14. ISBN ... has very real consequences. We can no longer afford to cast nature to the side."[225] ... "Holistic screening of collapsing honey bee colonies in Spain: a case study". BMC Research Notes. 7: 649. doi:10.1186/1756-0500 ... Winchester, MA: Allen & Unwin. ISBN 978-0-04-551068-9. .. *^ Davis, M. B. (1976). "Pleistocene biogeography of temperate ...
1363 (D. Mass. 1969)), the United States Court of Appeals for the Second Circuit, and the Supreme Court of the United States ( ... a real original that has suffered from public incomprehension since its release and is crying out for reassessment and ... "Screen: 'I Am Curious (Yellow)' From Sweden - The New York Times". Retrieved 2018-09-19 ... In 1969, the film was banned in Massachusetts for being pornographic and Boston police seized the film reels for I Am Curious ( ...
"Physicist Claims First Real Demonstration of Cold Fusion",, 27 May 2008. . The peer reviewed papers referenced at ... Electron screening of the positive hydrogen nuclei by the negative electrons in the palladium lattice was suggested to the 2004 ... Shanahan, Kirk L. (23 May 2002), "A systematic error in mass flow calorimetry demonstrated", Thermochimica Acta, 382 (2): 95- ... The Massachusetts Institute of Technology (MIT) announced on 12 April 1989 that it had applied for its own patents based on ...
Films, premières and live orchestra screeningsEdit. The venue has screened several films since the early silent days. It was ... Recordings from the Royal Albert Hall concerts on 26-27 May 1966 were finally released by the artist in 2016 as The Real Royal ... University of Massachusetts Press. pp. 210-212. ISBN 1-55849-505-3. Retrieved 17 June 2011.. ... The Hall has curated regular seasons of film-and-live-orchestra screenings since 2009, including the Lord of the Rings trilogy ...
Tolle MA (April 2009). "Mosquito-borne diseases". Curr Probl Pediatr Adolesc Health Care. 39 (4): 97-140. doi:10.1016/j.cppeds. ... Anales de la Real Academia de Ciencias Médicas, Físicas y Naturales de la Habana, 18 : 147-169. Available on-line in English at ... Staying in accommodations with screened or air-conditioned rooms, particularly during peak biting times, also reduces the risk ... de Souza RP, Foster PG, Sallum MA, Coimbra TL, Maeda AY, Silveira VR, Moreno ES, da Silva FG, Rocco IM, Ferreira IB, Suzuki A, ...
Pressing F5 in Lotus Notes before release 8.0 caused it to lock screen. Since this was a major point of criticism this was ... Replication between servers may occur at intervals according to a defined schedule, in near-real-time when triggered by data ... "IBM Lotus Notes File versions", Puttin' on the Bits Blog, Littleton, Mass: IBM. ... This add-on allowed Notes documents to be rendered as web pages in real time. Later that year, the Domino web server was ...
Cuantificación e localización subcelular con alta produtividade e precisión (high-content screening, citohistopatoloxía).[132] ... Cuantificación do tamaño da oclusión a través de imaxes en tempo real, tanto do desenvolvemento coma da recuperación, de ... "Bioinformatics in mass spectrometry data analysis for proteomics studies". Expert Review of Proteomics 1 (4). Páxs. 469-483. ... Determinación de patróns no fluxo do aire en tempo real da respiración pulmonar de animais vivos. ...
Wood, B. (1987). "Who is the 'real' Homo habilis?". Nature. 327 (6119): 187-188. doi:10.1038/327187a0. PMID 3106828.. ... 2015). "Early Homo at 2.8 Ma from Ledi-Geraru, Afar, Ethiopia". Science. 347 (6228): 1352-1355. doi:10.1126/science.aaa1343.. ... bending upright branches as poles and using grasses or animal hide as a screen.[57] Dating to 1.75 mya, it is attributed to ... However, relative female body mass is unknown in this species.[29] Early hominins, including H. habilis, are thought to have ...
Bhumibol was born at Mount Auburn Hospital in Cambridge, Massachusetts, in the United States, on 5 December 1927.[22] He was ... In the early years of his reign, during the government of military dictator Plaek Phibunsongkhram, Bhumibol had no real ... was the focus of a two-minute long documentary created by the government of Abhibisit Vejjajiva that was screened at all ... Mount Auburn Hospital, Cambridge, Massachusetts, United States. Died. 13 October 2016(2016-10-13) (aged 88). Siriraj Hospital, ...
Having no real knowledge of the Arabs' true military capabilities, the Jews took Arab propaganda literally, preparing for the ... In December 1942, when the mass murder of European Jewry became known to the Allies, the British continued to refuse to change ... Over 6,000 people were screened, of which a small percentage were detained, and a meager amount of weapons and ammunition was ... Overall, between 1929 and 1940, a period of mass Jewish immigration known as the Fifth Aliyah occurred despite British ...
Simon Reveals his Real Thoughts on the Hill "UFO Abduction" Case *^ Bryce Zabel (February 23, 2018), UFO Abductee Barney Hill ... Fuller, John G. (1975). Interrupted Journey (mass market paperback edition). Berkley Publishing Group. ISBN 0-425-03002-4. ... "Alien Abduction Tale Heads to the Big Screen". .mw-parser-output cite.citation{font-style:inherit}.mw-parser- ... the Hill map bore no resemblance to the real-life map. In contrast, those more favorable to the map, such as David Saunders, a ...
At very low frequencies (s≈0), the two reactive terms are negligible, so the impedance is real-valued and looks like Z. D. C. = ... This type of coax offers superior screening compared to cables with a braided outer conductor, especially at higher frequencies ... Real cables have a shield made of an imperfect, although usually very good, conductor, so there must always be some leakage. ... At higher frequences, the reactive terms usually dominate R and G, and the cable impedance again becomes real-valued. That ...
... as some supplies were mistakenly sent to the real Fall River, in Massachusetts.[18] ... After the initial sighting, the main invasion force, consisting of the heavy naval screening force and the two transports, ...
"Black Screen". Retrieved 6 May 2018.. *^ "Archived copy". Archived from the original on 8 April 2013. Retrieved 20 December ... Barack Obama's real problem isn't that he's too white - it's that he's too black.. ... see Ma malakat aymanukum and sex),[11][12] leading to many mixed-race children. When an enslaved woman became pregnant with her ...
Schwartz, C.; Meisenhelder, J.; Ma, Y.; Reed, G. (2003). "Altruistic Social Interest Behaviors Are Associated With Better ... to subtle cues such as people being more helpful when there were stylized eyespots instead of a logo on a computer screen. Weak ... unimportant if there are stronger cues present and may lose their effect with continued exposure unless reinforced with real ...
An antique gasoline engine with an evaporative cooler and mesh screen to improve evaporation. Water is pumped up to the top and ... Total dissolved solids or TDS (sometimes called filtrable residue) is measured as the mass of residue remaining when a measured ... "Subambient Cooling of Water: Toward Real-World Applications of Daytime Radiative Cooling". Joule. 3: 111-123. doi:10.1016/j. ... High temperatures or pump turbulence and shear may kill or disable smaller organisms passing the screens entrained with the ...
... or acted on the silver screen, to include: Ann Forrest, Anders Randolf, Bodil Rosing, Benjamin Christensen, Carl Brisson, Carl ... Upon release Holstein invested in real estate and offered mortgages to minorities in the Harlem community until his death in ... Danish Society of Massachusetts. *Rebild National Park Society. *Danes Worldwide. *Bien Newspaper ...
Although Grossman's article began with the confession that "I don't even know his real name," he claimed to identify moot as ... He started 4chan pseudonymously, under the screen name moot. In 2016, he began working for Google. ... he has spoken at conferences at Yale University and Massachusetts Institute of Technology.[31] A 2008 article in The Observer ... in contrast to the merger of online and real-world identities occurring on Facebook and many other social networking sites.[15] ...
I may view the itinerary from my office on a large screen and want to see the map, or I may view it at the airport from my ... At one time, half the world had mobile phones.[14] The articles in 2007-2008 were slightly misleading because the real story at ... Small screen size - this makes it difficult or impossible to see text and graphics dependent on the standard size of a desktop ... To display more information, smartphone screen sizes have been getting bigger.. *Lack of windows - on a desktop computer, the ...
ScreeningEdit. Screening among family members of people with known FH is cost-effective.[22] Other strategies such as universal ... Its real function is unclear, but it seems to play a role in the relation between the LDL receptor and clathrin-coated pits. ... Umans-Eckenhausen MA, Defesche JC, Sijbrands EJ, Scheerder RL, Kastelein JJ (January 2001). "Review of first 5 years of ... Screening of toddlers has been suggested, and results of a trial on 10,000 one-year-olds were published in 2016. Work was ...
A television screen shows ultrasound images of a fetus. As the images of an abortion appear on the screen, Nathanson describes ... Retrieved from Communication & Mass Media Complete database.[verification needed] *^ Sajid Surve, May 10, 2009. Medical ... and to witness an abortion in real time "from the victim's vantage point."[9] The film compiled a series of still ultrasound ...
Sherif then obtained MA degree from the Istanbul University in 1928,[1] where he also expressed his support for the ... He emphasizes that real world contexts are important, even if regarded as "messy" compared to controlled lab experiments. ... The participants were carefully screened to be psychologically normal, and they did not know each other. Sending them to such a ... Sherif went to America during the peak of the Great Depression, earning an MA from Harvard University where his teachers were ...
"Jane Roe" of the landmark Roe v. Wade lawsuit, whose real name is Norma McCorvey, became a pro-life advocate later in her life ... 17 states (AK, AZ, CA, CT, HI, IL, MD, MA, MN, MT, NJ, NM, NY, OR, VT, WA, WV) use their own funds to cover all or most " ... by this provision for the mother's mental health that women in the US legally choose abortion after viability when screenings ... "Mary Doe" of the companion Doe v. Bolton lawsuit, the mother of three whose real name is Sandra Cano, maintains that she never ...
Lamport, Leslie (1994), LaTeX: A Document Preparation System (2nd ed.), Reading, MA: Addison-Wesley, ISBN 0-201-52983-1. . ... and includes a real, Turing-complete programming language, following intense lobbying by Guy Steele.[8] In 1989, Donald Knuth ... A DVI file could then either be viewed on screen or converted to a suitable format for any of the various printers for which a ... 1986), TeX: The Program, Computers and Typesetting, B, Reading, MA: Addison-Wesley, ISBN 0-201-13437-3. . The full source code ...
Mehandru S, Poles MA, Tenner-Racz K, Horowitz A, Hurley A, Hogan C, Boden D, Racz P, Markowitz M (2004). "Primary HIV-1 ... Definicións no Dicionario da Real Academia Galega e no Portal das Palabras para sida. ... 2012). "Screening for HIV: systematic review to update the 2005 U.S. Preventive Services Task Force recommendation". Ann. ... Klimas, N; Koneru, AO; Fletcher, MA (2008 Jun). "Overview of HIV". Psychosomatic Medicine 70 (5): 523-30. PMID 18541903. doi: ...
To validate the specimen-pooling strategy for real-time reverse transcription PCR detection of severe acute respiratory ... Pooling Upper Respiratory Specimens for Rapid Mass Screening of COVID-19 by Real-Time RT-PCR So Yeon Kim1, Jaehyeon Lee1, ... Pooling Upper Respiratory Specimens for Rapid Mass Screening of COVID-19 by Real-Time RT-PCR. ...
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The province will not develop a mass screening tool to easily and quickly detect the B.1.617 coronavirus variant first ... Toronto real estate agents using new tactic to fuel competition and boost housing prices ... Ontario not building mass screening tool to detect B.1.617 COVID-19 variant; 45 cases now confirmed. Travellers, who are not ... UK authorities have also designated B.1.617 a variant of concern and are using mass PCR test sample screening and whole genomic ...
Ontario is not in the process of developing a mass screening technique to detect the B.1.617 coronavirus variant currently ... Toronto real estate agents using new tactic to fuel competition and boost housing prices ... Ontario not developing mass screening tool for B.1.617 COVID-19 variant devastating India. Travellers, who are not affected by ... Ontario is not in the process of developing a mass screening technique to detect the B.1.617 coronavirus variant currently ...
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Newborn screening for 3-hydroxy-3-methylglutaric aciduria using direct analysis in real-time mass spectrometry.. Huang Z1, Liu ... 3-Hydroxy-3-methylglutaric acid; direct analysis in real-time mass spectrometry; newborn screening; urine ... A novel method utilizing ambient thermal desorption ionization with a direct analysis in real-time source integrated with mass ... The proposed method demonstrated significant potential in the application of the high-throughput screening in newborn screening ...
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Brink, S. Little-used newborn test can prevent real heartache. U.S. News Online 2000. Available at , ... Automated tandem mass spectrometry for mass newborn screening for disorders in fatty acid, organic acid, and amino acid ... Laboratory integration and utilization of tandem mass spectrometry in neonatal screening: a model for clinical mass ... Increasingly, tandem mass spectrometry (MS/MS) is being used for newborn screening because this laboratory testing technology ...
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  • Newborn screening for 3-hydroxy-3-methylglutaric aciduria using direct analysis in real-time mass spectrometry. (
  • A novel method utilizing ambient thermal desorption ionization with a direct analysis in real-time source integrated with mass spectrometry (DART-MS) was established and applied to the rapid analysis of 3-hydroxy-3-methylglutaric (3-HMG) acid in the neonatal urine. (
  • Increasingly, tandem mass spectrometry (MS/MS) is being used for newborn screening because this laboratory testing technology substantially increases the number of metabolic disorders that can be detected from dried blood-spot specimens. (
  • The introduction of tandem mass spectrometry (MS/MS) in the 1990s for population-based newborn screening has enabled health-care providers to detect an increased number of metabolic disorders in a single process by using dried blood-spot specimens routinely collected from newborns ( 13 ). (
  • Saugus, MA, November 04, 2013 --( )-- IonSense, Inc. will be exhibiting the latest advances in Direct Analysis in Real Time (DART®) Mass Spectrometry at the 6th International Symposium on Recent Advances in Food Analysis, November 5-8, 2013 in Prague, Czech Republic. (
  • IonSense, Inc. provides OpenSpot Mass Spectrometry™ solutions to the fields of food safety, forensics, drug development, and chemical analysis. (
  • Todaylj labs need and want more from their chromatography so many have turned to mass spectrometry for greater insights and precise data. (
  • Our mass spectrometry solutions are built around proven technology that is designed to meet your growing analytical lab requirements. (
  • In this study, a robust method based on isotope dilution liquid chromatography-tandem mass spectrometry (ID LC-MS/MS) was developed to simultaneously measure E1, E2 and E3 in infant formulas with no need for any derivatization step. (
  • Rapid Identification of Synthetic Cannabinoids in Herbal Samples via Direct Analysis in Real Time Mass Spectrometry - R. A. Musah, M. A. Domin, M. A. Walling, and J. R. E. Shepard, Rapid Commun. (
  • To address this new and important challenge in forensic chemistry, Direct Analysis in Real Time Mass Spectrometry (DART-MS) is applied to the analysis of these designer drugs. (
  • Online analytical capabilities include molecular beam mass spectrometry, gas chromatography, thermal conductivity detection, and nondispersive infrared. (
  • Product analysis is achieved through online chromatography and mass spectrometry and a multitude of offline techniques, like nuclear magnetic resonance, high-performance liquid chromatography, scanning electron microscopy with X-ray microanalysis, transmission electron microscopy, X-ray diffraction, Fourier transform infrared spectroscopy, Raman, etc. (
  • Tandem mass spectrometry (TMS) and T-cell-receptor excision circles (TRECs) can identify early-onset ADA deficiency at birth, on dried blood spot (DBS) taken within the routine newborn screening procedure. (
  • Extensive research into the detection of NPS, including synthetic cathinones, in seized material, has employed gas chromatography-mass spectrometry (GC-MS) 8 and liquid chromatography-high resolution mass spectrometry (LC-HRMS) 9 for confirmatory analysis. (
  • Increasing demand for minimal sample preparation has seen infrared and Raman spectroscopy 10 studies as well as ambient ionisation mass spectrometric analyses, such as direct analysis in real time mass spectrometry (DART-MS) 11 , 12 . (
  • The need for rapid, sensitive analysis in the field has also seen the incorporation of paper spray ionization-mass spectrometry (PSI-MS) into portable devices for use by law enforcement 13 . (
  • Here we present a high-throughput, label-free and unbiased screening approach for the identification of small molecule ligands towards GPCR targets based on affinity mass spectrometry. (
  • Affinity mass spectrometry (MS) has emerged as a powerful approach for analyzing protein-ligand interaction and it plays a vital role in early-phase drug discovery. (
  • On 16 April 2020, a COVID-19 mass screening program was initiated in Saudi Arabia in multiple phases. (
  • A retrospective cross-sectional study was conducted among the high-risk population as part of the COVID-19 mass screening program across all regions in Saudi Arabia during April and May 2020. (
  • It also screened at the New York Film Festival on September 20, 2020. (
  • Let's finish off 2020 on a good note with a real bang! (
  • Testing pooled specimens is a well-known meth- PowerCheck 2019-nCoV Real-Time Detection (Kogene od and has been used in blood banks worldwide to Biotech, (
  • To validate the specimen-pooling strategy for real-time reverse transcription PCR detection of severe acute respiratory syndrome coronavirus 2, we generated different pools including positive specimens, reflecting the distribution of cycle threshold values at initial diagnosis. (
  • Real-time reverse transcription PCR (rRT-PCR) detection of the causative agent, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a confirmatory diagnostic tool for COVID-19 ( 3 ). (
  • Laboratory diagnosis of SARS-CoV-2 infection was performed with all specimens using the following rRT-PCR kits targeting the E and RdRp genes: STANDARD M nCoV Real-time Detection (SD Biosensor, ) or PowerCheck 2019-nCoV Real-Time Detection (Kogene Biotech, ). (
  • MS/MS technology expands the metabolic disorder screening panel (i.e., the number of disorders that can be detected) by incorporating an acylcarnitine profile, which enables detection of fatty acid oxidation disorders (e.g., medium-chain acyl-CoA dehydrogenase [MCAD] deficiency) ( 7-10 ) and other organic acid disorders. (
  • A simple blood test would increase screening compliance, promoting early detection and better patient outcomes. (
  • Mistral Solutions, a technology design, and system engineering company, announces the introduction of an Automated Thermal Screening System, a body temperature detection and alert system for large establishments and public places to be placed at the entry and exit points. (
  • The ATS System offers faster people detection and temperature measurement and generates real-time, accurate data for active monitoring and quick decision making. (
  • Based on our experience, launching mass screening programs is crucial for early case detection, isolation, and pattern recognition for immediate public interventions. (
  • Although the diagnosis of COVID-19 depends on the epidemiological linkage and clinical presentation, the most reliable method for virus detection is by analyzing respiratory discharges through real-time quantitative polymerase chain reaction (RT-qPCR) ( 7 ). (
  • A crucial difference between the biosensor research for which Jae Wan Kwon received a coveted National Science Foundation (NSF) CAREER award and other acoustic resonant sensors is the ability of Kwon's devices to do highly sensitive real-time mass detection in liquid environments. (
  • DELRAY BEACH, Fla., Sept. 23, 2014 (GLOBE NEWSWIRE) -- PositiveID Corporation ("PositiveID" or "Company") (OTCQB:PSID), a developer of biological detection and diagnostics solutions, today announced that it is accelerating the prototype development of its Firefly Dx system, a handheld, real-time PCR (polymerase chain reaction) system designed to provide molecular diagnostic results in less than 20 minutes at the point of need. (
  • These designer drugs are difficult to identify in conventional drug screens not only because routine protocols have not been developed for their detection, but also because their association with complex plant matrices during manufacture generally requires labor-intensive extraction and sample preparation for analysis. (
  • This new approach features the usage of target-expressing cell membranes rather than purified proteins for ligand screening and allows the detection of both orthosteric and allosteric ligands targeting specific GPCRs. (
  • The proposed method demonstrated significant potential in the application of the high-throughput screening in newborn screening. (
  • In June 2000, the National Newborn Screening and Genetics Resource Center, in collaboration with CDC and the Health Resources and Services Administration, convened a workshop in San Antonio, Texas. (
  • Workshop participants examined programmatic concerns for health providers choosing to integrate MS/MS technology into their newborn screening activities. (
  • This work group report contains proposals for planning, operating, and evaluating MS/MS technology in newborn screening and maternal and child health programs. (
  • As a supplement to these proposals, this report contains synopses of selected presentations made at the 2000 workshop regarding integration of MS/MS technology into newborn screening programs. (
  • The proposals contained in this report should assist policymakers, program managers, and laboratorians in making informed decisions regarding the process of including MS/MS technology in their newborn screening and maternal and child health programs. (
  • Each year, approximately 4 million babies in the United States have dried blood spots analyzed through newborn* screening programs. (
  • These three groups of disorders account for approximately 3,000 new cases of potentially fatal or debilitating disease each year for which outcomes are improved with early identification and treatment through newborn screening systems. (
  • However, using MS/MS in newborn screening programs is new, and scientific data are limited regarding incorporating this technology into newborn screening and maternal and child health programs. (
  • From newborn screening to genetic testing regulation, family health history, and tools for running an advocacy organization, the collection of recorded webinars offers a wide array of information on an equal wide array of topics. (
  • Actually, TMS is routinely used all over the world for newborn screening of metabolic diseases such as hypothyroidism and over 20 million children are screened every year by that method. (
  • TREC assay is used in the USA and other Western countries for newborn screening of SCID and seems to be, at present, the best candidate for that application. (
  • TMS is currently used in a pilot study for newborn screening of SCID in Tuscany, Italy. (
  • The inclusion of TMS analysis of adenosine and 2'-deoxyadenosine in the routine newborn screening is recommended, so that all variants of ADA deficiency could be diagnosed at birth. (
  • The province will not develop a mass screening tool to easily and quickly detect the B.1.617 coronavirus variant first discovered in India, as officials said they are now aware of 45 cases throughout Ontario. (
  • Ontario is not in the process of developing a mass screening technique to detect the B.1.617 coronavirus variant currently devastating India and already present in the province because global authorities have not yet deemed it a variant of concern. (
  • In this review, we provide an overview of the literature on respiratory infections at mass gatherings, then describe the impact of novel coronavirus 2012 (nCoV), an emerging respiratory disease virus, on the preparations for mass gathering. (
  • After witnessing exponential spread that eventually saw an earlier variant, B.1.1.7, become the dominant strain in the province, PHO and its allied labs developed a screening tool earlier this year that could classify positive COVID-19 samples as likely variants of concern quickly and easily without resorting to whole genomic sequencing. (
  • UK authorities have also designated B.1.617 a variant of concern and are using mass PCR test sample screening and whole genomic sequencing to help detect it. (
  • Instead of developing a PCR-based screen for B.1.617, Public Health Ontario says it is instead running five per cent of samples that test negative for the specific spike protein mutation found in the UK and South African variants through whole genomic sequencing, with help coming from the National Microbiology lab in Winnipeg. (
  • Our global laboratories offer one of the world's most comprehensive genomic screening and testing programs. (
  • They recommend it in particular for e-paper and OLED screens, although it will work with anything except LCD (which doesn't like to be pressed). (
  • OLED screens and dubious FaceID? (
  • Apple thinks we want an OLED screen, face recognition and a flatter handset. (
  • Dust monitor is equipment which is designed in such a way so that it can provide continuous real-time measurement of dust. (
  • This very low power consumption system transfers, in real time, data measurement via BlueTooth Low Energy. (
  • On board help screens for measurement functions. (
  • Best of all, a real-time preview of the measurement area ensures your measurement target is exactly where you want it to be. (
  • Included with the MA-T6 and MA-T12, EFX QC is a cloud-based software solution that offers new visual tools, including performance trend charts and stored measurement images. (
  • The MA-T6 offers the ability to characterize effect finishes across a variety of applications using six angles of measurement coupled with color imaging. (
  • With the MA-T12, you can fully characterize and measure color shifting pigments across a variety of applications through 12 measurement angles and color imaging, enabling the most complete characterization of today's extreme effect materials. (
  • MS/MS technology enables improvements in and consolidation of metabolic screening methods to detect amino acid disorders (e.g. (
  • Moreover, the traditional methods of screening are mostly man-managed, resulting in delays, congestion and have their own limitations such as close contact with people, high risk of transmitting infection, high cost, low efficiency, etc. (
  • However, due to limitations inherent to the most common techniques for GPCR ligand discovery, there is a pressing need for more efficient and effective ligand screening methods especially for the identification of potential allosteric modulators. (
  • Ontario has a rigorous and widespread screening program to detect the B.1.1.7 variant first discovered in the UK, the P.1 variant first found in Brazil and the B.1.353 variant first discovered in South Africa, with a majority of all positive samples run through screening to determine their likely lineage. (
  • This screening is intended to detect inborn disorders that can result in early mortality or lifelong disability. (
  • The Firefly Dx is designed with the capability to screen for and detect multiple strains of the virus simultaneously with a single test. (
  • Real-time reverse tran- consent from participants was waived. (
  • Laboratory diagnosis of and subsequently retesting single specimens from SARS-CoV-2 infection was performed with all speci- positive pools is an efficient strategy for rapid mass mens using the following rRT-PCR kits targeting the E screening as well as for increasing testing capacity and RdRp genes: STANDARD M nCoV Real-time and conserving resources. (
  • They manufacture and develop direct analysis in real time (DART®) and atmospheric solids analysis probe (ASAP™) technology. (
  • You can record real-time data in chart or table format as per your own preference. (
  • It provides real-time mass concentration readings. (
  • An energy monitor makes it easy to track your energy use in real time and can be a good accessory to have around when you're concerned about your energy costs. (
  • Get real-time transcription and block unwanted callers so you'll never hear from them again. (
  • At the same time, the specialty group took issue with the panel's decision to maintain its recommendation against screening for men 70 and older, saying that healthier older men might benefit from the test. (
  • Mass Effect" employs a real-time, squad based, tactical combat system. (
  • The new DustTrak Aerosol Monitors are battery-operated, data-logging, light-scattering laser photometers that give you real-time aerosol mass readings. (
  • This time I am looking at the use of dynamic memory in real-time embedded applications. (
  • Results are generated in real-time, making it an attractive solution for mass screening, especially in areas with high human traffic. (
  • Analysis of bacterial phylum, genus, and species was performed by real-time polymerase chain reaction in fecal samples. (
  • Access to real-time, reference, and non-real time data in the cloud to power your enterprise. (
  • Real time clock for automatic time stamping of saved readings. (
  • It will only be a matter of time before we start hearing stories of device screen breakages - both front and back - increasing the cost of ownership. (
  • The high mass resolution time-of-flight analyzer allowed identification of these substances despite their presence within a complex matrix and enabled differentiation of closely related analogs. (
  • Real-time or Quantitative PCR and RT-PCR use the linearity of DNA amplification to determine absolute or relative amounts of a known sequence in a sample. (
  • Real time PCR also lends itself to relative studies. (
  • In the same DBS, TRECs were measured, using Real time PCR. (
  • Actually, since TMS uses the same operators, the same procedures, the same instruments already used for routine TMS screenings, and can be performed at the same time, the cost is about $0.01. (
  • 4. Monitor and share real-time performance. (
  • It also provides real-time performance monitoring and actionable insights to help troubleshooting out-of-tolerance colors. (
  • This study describes the real-time body positions of 2 nursing home (NH) residents, residing in the United States and living with dementia, to inform development of PrI prevention strategies tailored to individual risk profiles. (
  • In this study, we described the real-time body positions of 2 NH residents LWD over multiple weeks to determine how PrI prevention strategies might be tailored to each unique individual risk profile. (
  • Mistral's Automated Thermal Screening (ATS) system is an Artificial Intelligence enabled mass people screening solution for establishments where a high footfall is expected, viz. (
  • Although it was built for portability and speed, the low thermal mass (LTM) capillary GC provides equivalent chromatographic resolution and performance to a benchtop system. (
  • An influential federal task force has dropped its controversial opposition to routine screening for prostate cancer and now says that men between the ages of 55 and 69 should discuss the test's potential benefits and harms with their doctors and make decisions based on their own "values and preferences. (
  • It is widely used for outdoor environmental monitoring, remote monitoring, emissions monitoring, baseline trending and screening and process monitoring etc. (
  • Applications include: Industrial/occupational hygiene surveys, Indoor air quality investigations, Outdoor environmental monitoring, Baseline trending and screening, Engineering control evaluations and more. (
  • But sequencing is laborious and costly, and will not allow for screening of every or even the majority of samples at current case rates. (
  • More importantly, the approach is highly sensitive, selective and accurate in screening estrogens in real infant formula samples. (
  • The highly stable and specific test reagent has the potential for use in the presumptive screening of unknown samples for synthetic cathinones in a forensic laboratory. (
  • The total of 101,999 passengers flooding TSA checkpoints on Mass Exodus Monday surpassed the previous record of 93,082 set on the Friday before Memorial Day 2018, according to TSA. (
  • Moreover, given the very low cost of the test, TMS can be useful in countries that cannot afford TREC analysis but are already using TMS to screen for other metabolic diseases. (
  • Most additive manufacturing techniques lack of solutions for mass production and multi-material systems. (
  • 3D printing process based on screen or stencil printing combines advantages of additive manufacturing with mass production. (
  • As they can be easily formulated in liquid solutions, these inks (combined with additive printing techniques, e.g. screen-print) allow the manufacturing of large area, flexible surfaces sensitive to touch, pressure or proximity. (
  • The decision about whether to be screened for prostate cancer should be an individual one," the U.S. Preventive Services Task Force said in a draft recommendation issued Tuesday. (
  • Dust monitor has a color coded screen so you can easily navigate and get instant readings on a large display. (
  • Screening a small compound library with this approach led to the rapid discovery of an antagonist for the 5-HT receptor and four positive allosteric modulators for GLP-1 receptor that were not previously reported. (
  • Aetna considers the use of maternal serum anti-Mullerian hormone level for first or second trimester screening for Down syndrome experimental and investigational because its effectiveness has not been established. (
  • Aetna considers Maternal Fetal Screen I T1 (Eurofins NTD, LLC) experimental and investigational for screening for fetal trisomies and pre-eclampsia because its effectiveness has not been established. (
  • Hours before Karl Rove saw Senator Scott Brown at the Republican National Convention in Tampa on Thursday, he screened an advertisement that related to the Massachusetts Senate race, according to BusinessWeek. (
  • Apple has done what it does best, take a nascent technology and reinvent it to take it to critical mass. (
  • once they reach critical mass, advertisers want out of the box (intrusive) custom integrations that drive users away. (
  • This is the first in a series of planned downloadable content that further expands the "Mass Effect" universe and continues the adventures of Commander Shepard and the Normandy crew. (
  • A mass screening test for COVID-19 is urgently and 300 individual SARS-CoV-2-negative specimens. (
  • A mass screening test for COVID-19 is urgently needed in South Korea because of the increasing number of confirmed cases in long-term care hospitals and public facilities, as well as imported cases. (
  • A sensitive blood-based CRC screening test using the SEPT9 biomarker specifically detects a majority of CRCs of all stages and colorectal locations. (
  • MaterniT21, MaterniT21 PLUS, Verifi Prenatal Test, Harmony Prenatal Test, Panorama Prenatal Test, QNatal Advanced) medically necessary for screening for fetal aneuploidy (trisomy 13, 18 and 21) in all pregnant women. (
  • Aetna considers NIPT not medically necessary for pregnant women who have previously had a multiple serum marker screening test with or without fetal nuchal translucency ultrasound that is negative for fetal aneuploidy during the current pregnancy. (
  • Developed by Breathonix, the breath test is a notable move away from the current screening standard involving a swab test. (
  • Small intestinal bacterial overgrowth was screened through hydrogen and methane breath test with lactulose. (
  • Westcott Properties is Rhode Island, Massachusetts and Florida's most innovative real estate team. (
  • No, we are not in the real estate biz and no, we don't get a finder's fee! (
  • The clear interface uses the screen real-estate very efficiently. (
  • There are 36 top-rated real estate services in your area. (
  • Welcome Home Nevada - Las Vegas Nevada Real Estate is great image for your collection and this design is free to use with high definitions resolution. (
  • Welcome Home Nevada - Las Vegas Nevada Real Estate is part of the popular collection wallpapers. (
  • Las Vegas Real Estate: Homes for Sale in Las Vegas, NV is part of the popular collection wallpapers. (
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  • 13.02.2015 at 10:35:21 Directly to a licensed local real estate agent who can guide you price. (
  • With mobile though, the limited real estate hinders these ad products and in addition, user expectations are different. (
  • Journal of the American Real Estate and Urban Economics Association, 5 , 473-481. (
  • Journal of Real Estate Finance and Economics, 9 , 263-294. (
  • The breath is collected and fed into a mass spectrometer to be measured. (
  • About half of Americans 50 to 75 years old do not follow recommended colorectal cancer (CRC) screening guidelines, leaving 40 million individuals unscreened. (
  • The panel's shift is the latest chapter in a long saga over prostate-cancer screening. (
  • From this point forward, the cancer became real and took the sovereignty I thought I had over my body. (
  • This easy-to-use, lightweight instrument enables rapid analysis and rapid screening of chemicals such as environmental volatiles and semivolatiles (VOCs/SVOCs), explosives, chemical threats, and hazardous substances - and provides equivalent chromatographic resolution and performance to a benchtop system. (
  • The sensor he has developed doesn't require bulky data reading and analysis instruments but can be integrated with equally small circuits, creating potential for small stand-alone disease-screening systems. (
  • He has previously worked at the New York University Game Center, Comparative Media Studies at Massachusetts Institute of Technology, and the Center for Computer Games Research at the IT University of Copenhagen. (
  • The NUS' research innovation team also is guiding Breathonix on securing regulatory approvals for its technology and for potential deployment to facilitate mass screening. (
  • Professor SHERRY TURKLE (Massachusetts Institute of Technology): It's not that it's not part of your real life just because it's happening on the screen. (
  • NuGEN and Caliper Partner to Eliminate Next-Gen Sequencing Sample Preparation B... ( SAN CARLOS Calif. and HOPKINTON Mass. (
  • Masimo Showcases Advanced, Noninvasive Patient Monitoring Technologies at A... ( IRVINE Calif. Jan. 27 2013 / Ma. (
  • Because of the ink's sensitivity, they can actually put the touch sensor behind the screen, reducing the cost of the screen itself and getting the electronics out of the way on the edges. (
  • ABSTRACT Mass gatherings are attended by an increasingly global audience and thus raise the concern of possible acute public health risks not normally encountered by the host population. (
  • Aetna considers PreSeek (a prenatal single gene cell-free fetal DNA screening panel for detecting multiple Mendelian monogenic disorders) experimental and investigational. (
  • Schreiber, who said he was drawn to Wepner's life as a cautionary tale of fame and celebrity, said that storytellers often exploit real people to create their narratives. (
  • In innumerable ways - from the rapidly increasing incarceration of women, to the gendered violence and criminalization that trans women, queer women, and gender non-conforming people face - we are witnessing mass incarceration's full-frontal attack on women's lives. (
  • People who think this replaces a real camera are delusional. (
  • Both tells us that thousands of people have gone missing in Mexico over recent years, probably kidnapped, possibly killed (the film starts at a mass grave) and there's a growing movement to do something about it. (
  • We get a huge mass of information like that from activists, journalists, people who've encountered the gangs and from desperate mothers. (
  • A recent outbreak of a "plague" in a popular online game has scientists considering how the virtual world may provide clues to what people would do in real-world pandemics. (
  • They started looking at the virtual world for clues about how people might react to an outbreak in the real world. (
  • This tax-free weekend is not only an opportunity to save a few dollars for consumers, but it's also an opportunity for people to buy local and keep more business here in the Commonwealth," Baker said, citing a Retailers Association of Massachusetts report that showed the sale tax holiday boosts retail by over $100 million. (
  • The MA-T can capture color, sparkle, and coarseness with industry-leading repeatability and reproducibility, reducing defects and ensuring a more efficient quality assurance program. (
  • Mayor Daniel Rivera, Governor Charlie Baker, Secretary of Administration and Finance Mike Heffernan, State Senator Barry Finegold, State Representatives Frank Moran, Christina Minicucci and Marcos Devers and Police Chief Roy Vasque announce the funding of a new police station in Lawrence through an agreement with the Commonwealth of Massachusetts. (
  • Wepner's life story has now arrived on the big screen with Liev Schreiber playing the Bayonne Bleeder in "Chuck," which opens on Friday in New York and Los Angeles before expanding nationwide starting next week. (
  • Support healthy aging and cognitive function* with the Real Red Pill from Infowars Life! (
  • Sadly, real life is a little more complicated. (
  • Galaxy Note10's pro-grade camera captures live video bokeh, giving real-life depth to every frame you shoot - so you can get perfect content to share with friends and followers. (
  • For a biopic of a real-life person, this feels like an oddly standard mob thriller. (
  • Players' decisions and actions will serve to shape the destiny of all life in the galaxy as you become absorbed in the story that is "Mass Effect," the first game in an epic trilogy from BioWare. (
  • We want to see campaigns that bring to life unforgettable real personalities-and tie them to organizational goals. (
  • As explored in Roadmap Step 4, Designing the Activity, these detailed descriptions of real-life interventions can be a powerful tool for organizations designing their own disparities-focused quality improvement project. (
  • The exit signs are not really this bright and annoying in real life. (
  • Easy to use Green Screen app that can bring learning to life! (
  • Advance aerosol monitoring from TSI Inc that simultaneously measures mass and size fraction. (
  • The DustTrak DRX monitor, for instance, is a new laser photometer that simultaneously measures both mass and size fraction - something no other monitor can do. (
  • MGM still needs final approvals from Springfield and the Massachusetts Gaming Commission but work has been underway for months. (
  • Massachusetts legalized casino gambling in 2011, and two years later, MGM was chosen by Springfield as its developer. (
  • Free Shipping FOB Springfield MA. (
  • He worries patients and doctors will think the panel concluded that it had made a mistake "and that it's all right to go back to a lot more screening and aggressive treatment. (
  • Shortly after, they announced a touch screen solution. (
  • The centrally located aperture and 3 positioning pins ensure stable measurements, while the touch screen navigation makes operation simple. (
  • And above all: Can we be sued blind by customers who hurt themselves because our products create temporary perceptual and proprioceptive confusion between what's virtual and what's real? (
  • Much Ado About Nothing" did much better than Shakespeare usually does on the screen, grossing $22.5 million. (
  • Mass screening programs were suggested by the World Health Organization (WHO) as an effective precautionary measure to contain the spread of the virus. (
  • This study aims to analyze the number of detected COVID-19 cases, their demographic data, and regions most affected in the initial two phases of these mass screening programs. (
  • The Essie Justice Group's recent report reveals the direct and dire consequences of mass incarceration on women with incarcerated loved ones who, like Tish, are left to bear the physical, emotional, and financial toll of the criminal legal system. (
  • Following an official Air Force inquiry, Lt. General Nathan Twining fired off a memo in late-1947 describing the "flying disc" phenomenon as "something real and not visionary or fictitious. (