A strain of albino rat developed at the Wistar Institute that has spread widely at other institutions. This has markedly diluted the original strain.
A strain of Rattus norvegicus used as a normotensive control for the spontaneous hypertensive rats (SHR).
Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.
A strain of Rattus norvegicus with elevated blood pressure used as a model for studying hypertension and stroke.
Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations or by parent x offspring matings carried out with certain restrictions. This also includes animals with a long history of closed colony breeding.
The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.
A process involving chance used in therapeutic trials or other research endeavor for allocating experimental subjects, human or animal, between treatment and control groups, or among treatment groups. It may also apply to experiments on inanimate objects.
Concentrated pharmaceutical preparations of plants obtained by removing active constituents with a suitable solvent, which is evaporated away, and adjusting the residue to a prescribed standard.
The measurement of an organ in volume, mass, or heaviness.
A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.
Elements of limited time intervals, contributing to particular results or situations.
The relationship between the dose of an administered drug and the response of the organism to the drug.
Rats bearing mutant genes which are phenotypically expressed in the animals.
Mutant strain of Rattus norvegicus which is used as a disease model of kernicterus.
PRESSURE of the BLOOD on the ARTERIES and other BLOOD VESSELS.
Body organ that filters blood for the secretion of URINE and that regulates ion concentrations.
Diabetes mellitus induced experimentally by administration of various diabetogenic agents or by PANCREATECTOMY.
Diet modification and physical exercise to improve the ability of animals to perform physical activities.
The restriction of a characteristic behavior, anatomical structure or physical system, such as immune response; metabolic response, or gene or gene variant to the members of one species. It refers to that property which differentiates one species from another but it is also used for phylogenetic levels higher or lower than the species.
Non-human animals, selected because of specific characteristics, for use in experimental research, teaching, or testing.
A clear, colorless liquid rapidly absorbed from the gastrointestinal tract and distributed throughout the body. It has bactericidal activity and is used often as a topical disinfectant. It is widely used as a solvent and preservative in pharmaceutical preparations as well as serving as the primary ingredient in ALCOHOLIC BEVERAGES.
Peroxidase catalyzed oxidation of lipids using hydrogen peroxide as an electron acceptor.
Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.
The dialdehyde of malonic acid.
A statistical technique that isolates and assesses the contributions of categorical independent variables to variation in the mean of a continuous dependent variable.
Naturally occurring or synthetic substances that inhibit or retard the oxidation of a substance to which it is added. They counteract the harmful and damaging effects of oxidation in animal tissues.
Use of plants or herbs to treat diseases or to alleviate pain.
A strain of Rattus norvegicus which is a model for spontaneous insulin-dependent diabetes mellitus (DIABETES MELLITUS, INSULIN-DEPENDENT).
A disturbance in the prooxidant-antioxidant balance in favor of the former, leading to potential damage. Indicators of oxidative stress include damaged DNA bases, protein oxidation products, and lipid peroxidation products (Sies, Oxidative Stress, 1991, pxv-xvi).
Forceful administration into the peritoneal cavity of liquid medication, nutrient, or other fluid through a hollow needle piercing the abdominal wall.
The observable response an animal makes to any situation.
Low-molecular-weight end products, probably malondialdehyde, that are formed during the decomposition of lipid peroxidation products. These compounds react with thiobarbituric acid to form a fluorescent red adduct.
Adverse functional, metabolic, or structural changes in ischemic tissues resulting from the restoration of blood flow to the tissue (REPERFUSION), including swelling; HEMORRHAGE; NECROSIS; and damage from FREE RADICALS. The most common instance is MYOCARDIAL REPERFUSION INJURY.
The consumption of liquids.
A nitrosoguanidine derivative with potent mutagenic and carcinogenic properties.
The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
Histochemical localization of immunoreactive substances using labeled antibodies as reagents.
A subtype of epilepsy characterized by seizures that are consistently provoked by a certain specific stimulus. Auditory, visual, and somatosensory stimuli as well as the acts of writing, reading, eating, and decision making are examples of events or activities that may induce seizure activity in affected individuals. (From Neurol Clin 1994 Feb;12(1):57-8)
The consumption of edible substances.
Glucose in blood.
An antibiotic that is produced by Stretomyces achromogenes. It is used as an antineoplastic agent and to induce diabetes in experimental animals.
A free radical gas produced endogenously by a variety of mammalian cells, synthesized from ARGININE by NITRIC OXIDE SYNTHASE. Nitric oxide is one of the ENDOTHELIUM-DEPENDENT RELAXING FACTORS released by the vascular endothelium and mediates VASODILATION. It also inhibits platelet aggregation, induces disaggregation of aggregated platelets, and inhibits platelet adhesion to the vascular endothelium. Nitric oxide activates cytosolic GUANYLATE CYCLASE and thus elevates intracellular levels of CYCLIC GMP.
The number of times the HEART VENTRICLES contract per unit of time, usually per minute.
A metabolite of TESTOSTERONE or ANDROSTENEDIONE with a 3-alpha-hydroxyl group and without the double bond. The 3-beta hydroxyl isomer is epiandrosterone.
An adrenocortical steroid that has modest but significant activities as a mineralocorticoid and a glucocorticoid. (From Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed, p1437)
An oxidoreductase that catalyzes the conversion of HYDROGEN PEROXIDE to water and oxygen. It is present in many animal cells. A deficiency of this enzyme results in ACATALASIA.
The muscle tissue of the HEART. It is composed of striated, involuntary muscle cells (MYOCYTES, CARDIAC) connected to form the contractile pump to generate blood flow.
Diseases of rodents of the order RODENTIA. This term includes diseases of Sciuridae (squirrels), Geomyidae (gophers), Heteromyidae (pouched mice), Castoridae (beavers), Cricetidae (rats and mice), Muridae (Old World rats and mice), Erethizontidae (porcupines), and Caviidae (guinea pigs).
The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM.
A 51-amino acid pancreatic hormone that plays a major role in the regulation of glucose metabolism, directly by suppressing endogenous glucose production (GLYCOGENOLYSIS; GLUCONEOGENESIS) and indirectly by suppressing GLUCAGON secretion and LIPOLYSIS. Native insulin is a globular protein comprised of a zinc-coordinated hexamer. Each insulin monomer containing two chains, A (21 residues) and B (30 residues), linked by two disulfide bonds. Insulin is used as a drug to control insulin-dependent diabetes mellitus (DIABETES MELLITUS, TYPE 1).
An oxidoreductase that catalyzes the reaction between superoxide anions and hydrogen to yield molecular oxygen and hydrogen peroxide. The enzyme protects the cell against dangerous levels of superoxide. EC 1.15.1.1.
Refers to animals in the period of time just after birth.
Enzymes of the transferase class that catalyze the conversion of L-aspartate and 2-ketoglutarate to oxaloacetate and L-glutamate. EC 2.6.1.1.
A transplantable carcinoma of the rat that originally appeared spontaneously in the mammary gland of a pregnant albino rat, and which now resembles a carcinoma in young transplants and a sarcoma in older transplants. (Stedman, 25th ed)
A non-selective inhibitor of nitric oxide synthase. It has been used experimentally to induce hypertension.
A subtype of striated muscle, attached by TENDONS to the SKELETON. Skeletal muscles are innervated and their movement can be consciously controlled. They are also called voluntary muscles.
Pathological processes consisting of the union of the opposing surfaces of a wound.
A colorless, odorless, viscous dihydroxy alcohol. It has a sweet taste, but is poisonous if ingested. Ethylene glycol is the most important glycol commercially available and is manufactured on a large scale in the United States. It is used as an antifreeze and coolant, in hydraulic fluids, and in the manufacture of low-freezing dynamites and resins.
An NADPH-dependent enzyme that catalyzes the conversion of L-ARGININE and OXYGEN to produce CITRULLINE and NITRIC OXIDE.
A response to a cue that is instrumental in avoiding a noxious experience.
A very loosely defined group of drugs that tend to reduce the activity of the central nervous system. The major groups included here are ethyl alcohol, anesthetics, hypnotics and sedatives, narcotics, and tranquilizing agents (antipsychotics and antianxiety agents).
The giving of drugs, chemicals, or other substances by mouth.
The surgical removal of one or both ovaries.
Regular course of eating and drinking adopted by a person or animal.
Application of a ligature to tie a vessel or strangulate a part.
Synthetic or natural substances which are given to prevent a disease or disorder or are used in the process of treating a disease or injury due to a poisonous agent.
An enzyme that catalyzes the conversion of L-alanine and 2-oxoglutarate to pyruvate and L-glutamate. (From Enzyme Nomenclature, 1992) EC 2.6.1.2.
The physical activity of a human or an animal as a behavioral phenomenon.
A family of enzymes accepting a wide range of substrates, including phenols, alcohols, amines, and fatty acids. They function as drug-metabolizing enzymes that catalyze the conjugation of UDPglucuronic acid to a variety of endogenous and exogenous compounds. EC 2.4.1.17.
An enzyme catalyzing the oxidation of 2 moles of glutathione in the presence of hydrogen peroxide to yield oxidized glutathione and water. EC 1.11.1.9.
An activity in which the body is propelled through water by specific movement of the arms and/or the legs. Swimming as propulsion through water by the movement of limbs, tail, or fins of animals is often studied as a form of PHYSICAL EXERTION or endurance.
The spurge family of flowering plants, in the order Euphorbiales, contains some 7,500 species in 275 genera. The family consists of annual and perennial herbs and woody shrubs or trees.
Injections into the cerebral ventricles.
Arteries which arise from the abdominal aorta and distribute to most of the intestines.
A tripeptide with many roles in cells. It conjugates to drugs to make them more soluble for excretion, is a cofactor for some enzymes, is involved in protein disulfide bond rearrangement and reduces peroxides.
Restoration of integrity to traumatized tissue.
Precursor of epinephrine that is secreted by the adrenal medulla and is a widespread central and autonomic neurotransmitter. Norepinephrine is the principal transmitter of most postganglionic sympathetic fibers and of the diffuse projection system in the brain arising from the locus ceruleus. It is also found in plants and is used pharmacologically as a sympathomimetic.
A diet that contains limited amounts of protein. It is prescribed in some cases to slow the progression of renal failure. (From Segen, Dictionary of Modern Medicine, 1992)
The tendency to explore or investigate a novel environment. It is considered a motivation not clearly distinguishable from curiosity.
Fats present in food, especially in animal products such as meat, meat products, butter, ghee. They are present in lower amounts in nuts, seeds, and avocados.
Preclinical testing of drugs in experimental animals or in vitro for their biological and toxic effects and potential clinical applications.
L-Tryptophyl-L-methionyl-L-aspartyl-L-phenylalaninamide. The C-terminal tetrapeptide of gastrin. It is the smallest peptide fragment of gastrin which has the same physiological and pharmacological activity as gastrin.
Orthodontic techniques used to correct the malposition of a single tooth.
Substances that increase the risk of NEOPLASMS in humans or animals. Both genotoxic chemicals, which affect DNA directly, and nongenotoxic chemicals, which induce neoplasms by other mechanism, are included.
Use of a device for the purpose of controlling movement of all or part of the body. Splinting and casting are FRACTURE FIXATION.

Sex differences in the effects of early neocortical injury on neuronal size distribution of the medial geniculate nucleus in the rat are mediated by perinatal gonadal steroids. (1/41636)

Freezing injury to the cortical plate of rats induces cerebrocortical microgyria and, in males but not females, a shift toward greater numbers of small neurons in the medial geniculate nucleus (MGN). The purpose of the current study was to examine a hormonal basis for this sex difference. Cross-sectional neuronal areas of the MGN were measured in male rats, untreated female rats and female rats treated perinatally with testosterone propionate, all of which had received either neonatal cortical freezing or sham injury. Both male and androgenized female rats with microgyria had significantly smaller MGN neurons when compared to their sham-operated counterparts, whereas untreated females with microgyria did not. These differences were also reflected in MGN neuronal size distribution: both male and androgenized female rats with microgyria had more small and fewer large neurons in their MGN in comparison to shams, while there was no difference in MGN neuronal size distribution between lesioned and sham females. These findings suggest that perinatal gonadal steroids mediate the sex difference in thalamic response to induction of microgyria in the rat cortex.  (+info)

Activation of alveolar macrophages in lung injury associated with experimental acute pancreatitis is mediated by the liver. (2/41636)

OBJECTIVE: To evaluate (1) whether alveolar macrophages are activated as a consequence of acute pancreatitis (AP), (2) the implication of inflammatory factors released by these macrophages in the process of neutrophil migration into the lungs observed in lung injury induced by AP, and (3) the role of the liver in the activation of alveolar macrophages. SUMMARY BACKGROUND DATA: Acute lung injury is the extrapancreatic complication most frequently associated with death and complications in severe AP. Neutrophil infiltration into the lungs seems to be related to the release of systemic and local mediators. The liver and alveolar macrophages are sources of mediators that have been suggested to participate in the lung damage associated with AP. METHODS: Pancreatitis was induced in rats by intraductal administration of 5% sodium taurocholate. The inflammatory process in the lung and the activation of alveolar macrophages were investigated in animals with and without portocaval shunting 3 hours after AP induction. Alveolar macrophages were obtained by bronchoalveolar lavage. The generation of nitric oxide, leukotriene B4, tumor necrosis factor-alpha, and MIP-2 by alveolar macrophages and the chemotactic activity of supernatants of cultured macrophages were evaluated. RESULTS: Pancreatitis was associated with increased infiltration of neutrophils into the lungs 3 hours after induction. This effect was prevented by the portocaval shunt. Alveolar macrophages obtained after induction of pancreatitis generated increased levels of nitric oxide, tumor necrosis factor-alpha, and MIP-2, but not leukotriene B4. In addition, supernatants of these macrophages exhibited a chemotactic activity for neutrophils when instilled into the lungs of unmanipulated animals. All these effects were abolished when portocaval shunting was carried out before induction of pancreatitis. CONCLUSION: Lung damage induced by experimental AP is associated with alveolar macrophage activation. The liver mediates the alveolar macrophage activation in this experimental model.  (+info)

Examination of the transverse tubular system in living cardiac rat myocytes by 2-photon microscopy and digital image-processing techniques. (3/41636)

The transverse tubular system (t-system) of cardiac muscle is a structure that allows rapid propagation of excitation into the cell interior. Using 2-photon molecular excitation microscopy and digital image-processing methods, we have obtained a comprehensive overview of the t-system of rat ventricular myocytes in living cells. We show that it is possible to quantify the morphology of the t-system in terms of average local tubule diameter, branching pattern, and local abundance of the t-system by immersing living myocytes in a dextran-linked fluorescein solution. Our data suggest that previous electron microscopic examinations of t-system structure have underestimated both the geometric complexity of the t-system morphology and the fraction of cell volume occupied by the t-system (3.6% in this species). About 40% of tubules occur between Z-lines, and the t-tubule diameter is 255+/-0.85 nm (mean+/-SEM). The t-tubules leave the outer surface of the cell in an approximately rectangular array; however, at some points junctions between the t-tubules and the surface membrane are missing. In view of the complexity of the t-system apparent from our images, we propose that the t-system be renamed the "sarcolemmal Z rete." The methods presented here are generally applicable to the quantification of the sarcolemmal Z rete and other structures within cells by fluorescence microscopy in a variety of cell types.  (+info)

Induction of serotonin transporter by hypoxia in pulmonary vascular smooth muscle cells. Relationship with the mitogenic action of serotonin. (4/41636)

-The increased delivery of serotonin (5-hydroxytryptamine, 5-HT) to the lung aggravates the development of hypoxia-induced pulmonary hypertension in rats, possibly through stimulation of the proliferation of pulmonary artery smooth muscle cells (PA-SMCs). In cultured rat PA-SMCs, 5-HT (10(-8) to 10(-6) mol/L) induced DNA synthesis and potentiated the mitogenic effect of platelet-derived growth factor-BB (10 ng/mL). This effect was dependent on the 5-HT transporter (5-HTT), since it was prevented by the 5-HTT inhibitors fluoxetine (10(-6) mol/L) and paroxetine (10(-7) mol/L), but it was unaltered by ketanserin (10(-6) mol/L), a 5-HT2A receptor antagonist. In PA-SMCs exposed to hypoxia, the levels of 5-HTT mRNA (measured by competitive reverse transcriptase-polymerase chain reaction) increased by 240% within 2 hours, followed by a 3-fold increase in the uptake of [3H]5-HT at 24 hours. Cotransfection of the cells with a construct of human 5-HTT promoter-luciferase gene reporter and of pCMV-beta-galactosidase gene allowed the demonstration that exposure of cells to hypoxia produced a 5.5-fold increase in luciferase activity, with no change in beta-galactosidase activity. The increased expression of 5-HTT in hypoxic cells was associated with a greater mitogenic response to 5-HT (10(-8) to 10(-6) mol/L) in the absence as well as in the presence of platelet-derived growth factor-BB. 5-HTT expression assessed by quantitative reverse transcriptase-polymerase chain reaction and in situ hybridization in the lungs was found to predominate in the media of pulmonary artery, in which a marked increase was noted in rats that had been exposed to hypoxia for 15 days. These data show that in vitro and in vivo exposure to hypoxia induces, via a transcriptional mechanism, 5-HTT expression in PA-SMCs, and that this effect contributes to the stimulatory action of 5-HT on PA-SMC proliferation. In vivo expression of 5-HTT by PA-SMC may play a key role in serotonin-mediated pulmonary vascular remodeling.  (+info)

Evidence for a vasopressin system in the rat heart. (5/41636)

Traditionally, a hypothalamo-neurohypophysial system is thought to be the exclusive source of arginine vasopressin (AVP), a potent antidiuretic, vasoconstricting, and growth-stimulating neuropeptide. We have identified de novo synthesis of AVP in the heart as well as release of the hormone into the cardiac effluents. Specifically, molecular cloning of sequence tags amplified from isolated, buffer-perfused, and pressure-overloaded rat hearts allowed the detection of cardiac AVP mRNA. Subsequent experiments revealed a prominent induction of AVP mRNA (peak at 120 minutes, 59-fold, P<0. 01 versus baseline) and peptide (peak at 120 minutes, 11-fold, P<0. 01 versus baseline) in these isolated hearts. Newly induced vasopressin peptide was localized most prominently to endothelial cells and vascular smooth muscle cells of arterioles and perivascular tissue using immunohistochemistry. In addition to pressure overload, nitric oxide (NO) participated in these alterations, because inhibition of NO synthase by Nomega-nitro-L-arginine methyl ester markedly depressed cardiac AVP mRNA and peptide induction. Immediate cardiac effects related to cardiac AVP induction in isolated, perfused, pressure-overloaded hearts appeared to be coronary vasoconstriction and impaired relaxation. These functional changes were observed in parallel with AVP induction and largely prevented by addition of a V1 receptor blocker (10(-8) mol/L [deamino-Pen1, O-Me-Tyr2, Arg8]-vasopressin) to the perfusion buffer. Even more interesting, pressure-overloaded, isolated hearts released the peptide into the coronary effluents, offering the potential for systemic actions of AVP from cardiac origin. We conclude that the heart, stressed by acute pressure overload or NO, expresses vasopressin in concentrations sufficient to cause local and potentially systemic effects.  (+info)

Role of nitric oxide-cGMP pathway in adrenomedullin-induced vasodilation in the rat. (6/41636)

We previously reported that adrenomedullin (AM), a potent vasodilator peptide discovered in pheochromocytoma cells, stimulates nitric oxide (NO) release in the rat kidney. To further investigate whether the NO-cGMP pathway is involved in the mechanisms of AM-induced vasodilation, we examined the effects of E-4021, a cGMP-specific phosphodiesterase inhibitor, on AM-induced vasorelaxation in aortic rings and perfused kidneys isolated from Wistar rats. We also measured NO release from the kidneys using a chemiluminescence assay. AM (10(-10) to 10(-7) mol/L) relaxed the aorta precontracted with phenylephrine in a dose-dependent manner. Denudation of endothelium (E) attenuated the vasodilatory action of AM (10(-7) mol/L AM: intact (E+) -25.7+/-5.2% versus denuded (E-) -7. 8+/-0.6%, P<0.05). On the other hand, pretreatment with 10(-8) mol/L E-4021 augmented AM-induced vasorelaxation in the intact aorta (-49. 0+/-7.9%, P<0.05) but not in the denuded one. E-4021 also enhanced acetylcholine (ACh)-induced vasorelaxation in the rat intact aorta (10(-7) mol/L ACh -36.6+/-8.4% versus 10(-8) mol/L E-4021+10(-7) mol/L ACh -62.7+/-3.1%, P<0.05). In perfused kidneys, AM-induced vasorelaxation was also augmented by preincubation with E-4021 (10(-9) mol/L AM -15.4+/-0.6% versus 10(-8) mol/L E-4021+10(-9) mol/L AM -23.6+/-1.2%, P<0.01). AM significantly increased NO release from rat kidneys (DeltaNO: +11.3+/-0.8 fmol. min-1. g-1 kidney at 10(-9) mol/L AM), which was not affected by E-4021. E-4021 enhanced ACh-induced vasorelaxation (10(-9) mol/L ACh -9.7+/-1.7% versus 10(-8) mol/L E-4021+10(-9) mol/L ACh -18.8+/-2.9%, P<0.01) but did not affect ACh-induced NO release from the kidneys. In the aorta and the kidney, 10(-4) mol/L of NG-nitro-L-arginine methyl ester, an NO synthase inhibitor, and 10(-5) mol/L of methylene blue, a guanylate cyclase inhibitor, reduced the vasodilatory effect of AM. These results suggest that the NO-cGMP pathway is involved in the mechanism of AM-induced vasorelaxation, at least in the rat aorta and kidney.  (+info)

Developmental synaptic changes increase the range of integrative capabilities of an identified excitatory neocortical connection. (7/41636)

Excitatory synaptic transmission between pyramidal cells and fast-spiking (FS) interneurons of layer V of the motor cortex was investigated in acute slices by using paired recordings at 30 degrees C combined with morphological analysis. The presynaptic and postsynaptic properties at these identified central synapses were compared between 3- and 5-week-old rats. At these two postnatal developmental stages, unitary EPSCs were mediated by the activation of AMPA receptors with fast kinetics at a holding potential of -72 mV. The amplitude distribution analysis of the EPSCs indicates that, at both stages, pyramidal-FS connections consisted of multiple functional release sites. The apparent quantal size obtained by decreasing the external calcium ([Ca2+]e) varied from 11 to 29 pA near resting membrane potential. In young rats, pairs of presynaptic action potentials elicited unitary synaptic responses that displayed paired-pulse depression at all tested frequencies. In older animals, inputs from different pyramidal cells onto the same FS interneuron had different paired-pulse response characteristics and, at most of these connections, a switch from depression to facilitation occurred when decreasing the rate of presynaptic stimulation. The balance between facilitation and depression endows pyramidal-FS connections from 5-week-old animals with wide integrative capabilities and confers unique functional properties to each synapse.  (+info)

Differential expression of the mRNA for the vanilloid receptor subtype 1 in cells of the adult rat dorsal root and nodose ganglia and its downregulation by axotomy. (8/41636)

Sensitivity to the pungent vanilloid, capsaicin, defines a subpopulation of primary sensory neurons that are mainly polymodal nociceptors. The recently cloned vanilloid receptor subtype 1 (VR1) is activated by capsaicin and noxious heat. Using combined in situ hybridization and histochemical methods, we have characterized in sensory ganglia the expression of VR1 mRNA. We show that this receptor is almost exclusively expressed by neurofilament-negative small- and medium-sized dorsal root ganglion cells. Within this population, VR1 mRNA is detected at widely varying levels in both the NGF receptor (trkA)-positive, peptide-producing cells that elicit neurogenic inflammation and the functionally less characterized glial cell line-derived neurotrophic factor-responsive cells that bind lectin Griffonia simplicifolia isolectin B4 (IB4). Cells without detectable levels of VR1 mRNA are found in both classes. A subpopulation of the IB4-binding cells that produce somatostatin has relatively low levels of VR1 mRNA. A previously uncharacterized population of very small cells that express the receptor tyrosine kinase (RET) and that do not label for trkA or IB4-binding has the highest relative levels of VR1 mRNA. The majority of small visceral sensory neurons of the nodose ganglion also express VR1 mRNA, in conjunction with the BDNF receptor trkB but not trkA. Axotomy results in the downregulation of VR1 mRNA in dorsal root ganglion cells. Our data emphasize the heterogeneity of VR1 mRNA expression by subclasses of small sensory neurons, and this may result in their differential sensitivity to chemical and noxious heat stimuli. Our results also indicate that peripherally derived trophic factors may regulate levels of VR1 mRNA.  (+info)

1) They share similarities with humans: Many animal species share similar biological and physiological characteristics with humans, making them useful for studying human diseases. For example, mice and rats are often used to study diseases such as diabetes, heart disease, and cancer because they have similar metabolic and cardiovascular systems to humans.

2) They can be genetically manipulated: Animal disease models can be genetically engineered to develop specific diseases or to model human genetic disorders. This allows researchers to study the progression of the disease and test potential treatments in a controlled environment.

3) They can be used to test drugs and therapies: Before new drugs or therapies are tested in humans, they are often first tested in animal models of disease. This allows researchers to assess the safety and efficacy of the treatment before moving on to human clinical trials.

4) They can provide insights into disease mechanisms: Studying disease models in animals can provide valuable insights into the underlying mechanisms of a particular disease. This information can then be used to develop new treatments or improve existing ones.

5) Reduces the need for human testing: Using animal disease models reduces the need for human testing, which can be time-consuming, expensive, and ethically challenging. However, it is important to note that animal models are not perfect substitutes for human subjects, and results obtained from animal studies may not always translate to humans.

6) They can be used to study infectious diseases: Animal disease models can be used to study infectious diseases such as HIV, TB, and malaria. These models allow researchers to understand how the disease is transmitted, how it progresses, and how it responds to treatment.

7) They can be used to study complex diseases: Animal disease models can be used to study complex diseases such as cancer, diabetes, and heart disease. These models allow researchers to understand the underlying mechanisms of the disease and test potential treatments.

8) They are cost-effective: Animal disease models are often less expensive than human clinical trials, making them a cost-effective way to conduct research.

9) They can be used to study drug delivery: Animal disease models can be used to study drug delivery and pharmacokinetics, which is important for developing new drugs and drug delivery systems.

10) They can be used to study aging: Animal disease models can be used to study the aging process and age-related diseases such as Alzheimer's and Parkinson's. This allows researchers to understand how aging contributes to disease and develop potential treatments.

Body weight is an important health indicator, as it can affect an individual's risk for certain medical conditions, such as obesity, diabetes, and cardiovascular disease. Maintaining a healthy body weight is essential for overall health and well-being, and there are many ways to do so, including a balanced diet, regular exercise, and other lifestyle changes.

There are several ways to measure body weight, including:

1. Scale: This is the most common method of measuring body weight, and it involves standing on a scale that displays the individual's weight in kg or lb.
2. Body fat calipers: These are used to measure body fat percentage by pinching the skin at specific points on the body.
3. Skinfold measurements: This method involves measuring the thickness of the skin folds at specific points on the body to estimate body fat percentage.
4. Bioelectrical impedance analysis (BIA): This is a non-invasive method that uses electrical impulses to measure body fat percentage.
5. Dual-energy X-ray absorptiometry (DXA): This is a more accurate method of measuring body composition, including bone density and body fat percentage.

It's important to note that body weight can fluctuate throughout the day due to factors such as water retention, so it's best to measure body weight at the same time each day for the most accurate results. Additionally, it's important to use a reliable scale or measuring tool to ensure accurate measurements.

Types of Experimental Diabetes Mellitus include:

1. Streptozotocin-induced diabetes: This type of EDM is caused by administration of streptozotocin, a chemical that damages the insulin-producing beta cells in the pancreas, leading to high blood sugar levels.
2. Alloxan-induced diabetes: This type of EDM is caused by administration of alloxan, a chemical that also damages the insulin-producing beta cells in the pancreas.
3. Pancreatectomy-induced diabetes: In this type of EDM, the pancreas is surgically removed or damaged, leading to loss of insulin production and high blood sugar levels.

Experimental Diabetes Mellitus has several applications in research, including:

1. Testing new drugs and therapies for diabetes treatment: EDM allows researchers to evaluate the effectiveness of new treatments on blood sugar control and other physiological processes.
2. Studying the pathophysiology of diabetes: By inducing EDM in animals, researchers can study the progression of diabetes and its effects on various organs and tissues.
3. Investigating the role of genetics in diabetes: Researchers can use EDM to study the effects of genetic mutations on diabetes development and progression.
4. Evaluating the efficacy of new diagnostic techniques: EDM allows researchers to test new methods for diagnosing diabetes and monitoring blood sugar levels.
5. Investigating the complications of diabetes: By inducing EDM in animals, researchers can study the development of complications such as retinopathy, nephropathy, and cardiovascular disease.

In conclusion, Experimental Diabetes Mellitus is a valuable tool for researchers studying diabetes and its complications. The technique allows for precise control over blood sugar levels and has numerous applications in testing new treatments, studying the pathophysiology of diabetes, investigating the role of genetics, evaluating new diagnostic techniques, and investigating complications.

There are two types of hypertension:

1. Primary Hypertension: This type of hypertension has no identifiable cause and is also known as essential hypertension. It accounts for about 90% of all cases of hypertension.
2. Secondary Hypertension: This type of hypertension is caused by an underlying medical condition or medication. It accounts for about 10% of all cases of hypertension.

Some common causes of secondary hypertension include:

* Kidney disease
* Adrenal gland disorders
* Hormonal imbalances
* Certain medications
* Sleep apnea
* Cocaine use

There are also several risk factors for hypertension, including:

* Age (the risk increases with age)
* Family history of hypertension
* Obesity
* Lack of exercise
* High sodium intake
* Low potassium intake
* Stress

Hypertension is often asymptomatic, and it can cause damage to the blood vessels and organs over time. Some potential complications of hypertension include:

* Heart disease (e.g., heart attacks, heart failure)
* Stroke
* Kidney disease (e.g., chronic kidney disease, end-stage renal disease)
* Vision loss (e.g., retinopathy)
* Peripheral artery disease

Hypertension is typically diagnosed through blood pressure readings taken over a period of time. Treatment for hypertension may include lifestyle changes (e.g., diet, exercise, stress management), medications, or a combination of both. The goal of treatment is to reduce the risk of complications and improve quality of life.

Reperfusion injury can cause inflammation, cell death, and impaired function in the affected tissue or organ. The severity of reperfusion injury can vary depending on the duration and severity of the initial ischemic event, as well as the promptness and effectiveness of treatment to restore blood flow.

Reperfusion injury can be a complicating factor in various medical conditions, including:

1. Myocardial infarction (heart attack): Reperfusion injury can occur when blood flow is restored to the heart muscle after a heart attack, leading to inflammation and cell death.
2. Stroke: Reperfusion injury can occur when blood flow is restored to the brain after an ischemic stroke, leading to inflammation and damage to brain tissue.
3. Organ transplantation: Reperfusion injury can occur when a transplanted organ is subjected to ischemia during harvesting or preservation, and then reperfused with blood.
4. Peripheral arterial disease: Reperfusion injury can occur when blood flow is restored to a previously occluded peripheral artery, leading to inflammation and damage to the affected tissue.

Treatment of reperfusion injury often involves medications to reduce inflammation and oxidative stress, as well as supportive care to manage symptoms and prevent further complications. In some cases, experimental therapies such as stem cell transplantation or gene therapy may be used to promote tissue repair and regeneration.

People with reflex epilepsy may experience a range of symptoms, including:

1. Seizures triggered by specific stimuli such as flashing lights, loud noises, or certain patterns or colors.
2. Loss of consciousness or awareness during the seizure.
3. Body stiffness or rigidity.
4. Jerky movements or twitches.
5. Altered sensation or perception.
6. Vision problems or blurred vision.
7. Hearing problems or ringing in the ears.
8. Nausea and vomiting.
9. Headaches.
10. Fatigue and exhaustion after the seizure.

Reflex epilepsy can be difficult to diagnose, as the seizures may not always be obvious or easy to identify. In some cases, people with reflex epilepsy may experience seizures that are triggered by internal stimuli, such as changes in hormone levels or stress, rather than external stimuli.

Treatment for reflex epilepsy typically involves avoiding triggers and managing stress, as well as medication to control seizures. In some cases, surgery may be recommended to remove the area of the brain that is causing the seizures. It's important for people with reflex epilepsy to work closely with their healthcare provider to develop a treatment plan that is tailored to their specific needs and circumstances.

1. Hantavirus pulmonary syndrome (HPS): This is a severe respiratory disease caused by the hantavirus, which is found in the urine and saliva of infected rodents. Symptoms of HPS can include fever, headache, muscle pain, and difficulty breathing.
2. Leptospirosis: This is a bacterial infection caused by the bacterium Leptospira, which is found in the urine of infected rodents. Symptoms can include fever, headache, muscle pain, and jaundice (yellowing of the skin and eyes).
3. Rat-bite fever: This is a bacterial infection caused by the bacterium Streptobacillus moniliformis, which is found in the saliva of infected rodents. Symptoms can include fever, headache, muscle pain, and swollen lymph nodes.
4. Lymphocytic choriomeningitis (LCM): This is a viral infection caused by the lymphocytic choriomeningitis virus (LCMV), which is found in the urine and saliva of infected rodents. Symptoms can include fever, headache, muscle pain, and meningitis (inflammation of the membranes surrounding the brain and spinal cord).
5. Tularemia: This is a bacterial infection caused by the bacterium Francisella tularensis, which is found in the urine and saliva of infected rodents. Symptoms can include fever, headache, muscle pain, and swollen lymph nodes.

These are just a few examples of the many diseases that can be transmitted to humans through contact with rodents. It is important to take precautions when handling or removing rodents, as they can pose a serious health risk. If you suspect that you have been exposed to a rodent-borne disease, it is important to seek medical attention as soon as possible.

Without more information about the context in which this term is being used, it is difficult to provide a clear definition or interpretation of its meaning. However, based on the name "Walker" and the fact that it is followed by a number (256), it is possible that this term may refer to a specific type of cancer or tumor that has been identified in a patient with the last name Walker.

It's important to note that the diagnosis and treatment of cancer can be complex and highly individualized, and any medical information or terminology should only be interpreted and applied by qualified healthcare professionals who have access to the relevant clinical context and patient information.

Examples of how 'Tissue Adhesions' is used in the medical field:

1. In gastrointestinal surgery, tissue adhesions can form between the intestines and other organs, leading to bowel obstruction, inflammation, or other complications.
2. In cardiovascular surgery, tissue adhesions can form between the heart and surrounding tissues, causing impaired heart function and increasing the risk of postoperative complications.
3. In gynecological surgery, tissue adhesions can form between the uterus and other pelvic organs, leading to pain, bleeding, and infertility.
4. In oncologic surgery, tissue adhesions can form between cancerous tissues and surrounding normal tissues, making it difficult to remove the tumor completely.
5. In chronic diseases such as endometriosis, tissue adhesions can form between the uterus and other pelvic structures, leading to pain and infertility.
6. Tissue adhesions can also form within the skin, causing keloids or other types of scarring.

Treatment options for tissue adhesions depend on the location, size, and severity of the adhesions, as well as the underlying cause. Some common treatment options include:

1. Surgical removal of adhesions: This involves surgically removing the fibrous bands or scar tissue that are causing the adhesions.
2. Steroid injections: Injecting steroids into the affected area can help reduce inflammation and shrink the adhesions.
3. Physical therapy: Gentle stretching and exercise can help improve range of motion and reduce stiffness in the affected area.
4. Radiofrequency ablation: This is a minimally invasive procedure that uses heat to break down and remove the fibrous bands causing the adhesions.
5. Laser therapy: Laser therapy can be used to break down and remove the fibrous bands causing the adhesions, or to reduce inflammation and promote healing.
6. Natural remedies: Some natural remedies such as turmeric, ginger, and omega-3 fatty acids have anti-inflammatory properties and may help reduce inflammation and improve symptoms.

Preventing tissue adhesions is not always possible, but there are some measures that can be taken to reduce the risk of their formation. These include:

1. Proper wound care: Keeping wounds clean and dry, and using sterile dressings can help prevent infection and reduce the risk of adhesion formation.
2. Minimizing trauma: Avoiding unnecessary trauma to the affected area can help reduce the risk of adhesion formation.
3. Gentle exercise: Gentle exercise and stretching after surgery or injury can help improve range of motion and reduce stiffness in the affected area.
4. Early mobilization: Early mobilization after surgery or injury can help reduce the risk of adhesion formation.
5. Avoiding smoking: Smoking can impede wound healing and increase the risk of adhesion formation, so avoiding smoking is recommended.
6. Using anti-adhesive agents: Applying anti-adhesive agents such as silicone or hydrogel to the affected area after surgery or injury can help reduce the risk of adhesion formation.

It's important to note that the most effective method for preventing or treating tissue adhesions will depend on the specific cause and location of the adhesions, as well as the individual patient's needs and medical history. A healthcare professional should be consulted for proper evaluation and treatment.

in Wistar rats". Journal of Ethnopharmacology. 134 (2): 294-297. doi:10.1016/j.jep.2010.12.019. ISSN 0378-8741. PMID 21182918. ...
In Wistar Rats. Asian Journal of Pharmaceutical and Clinical Research, 5(4), 141-145. Singh V, Kumar R.(2017).Study of ... "Hepatoprotective activity of Clearliv a polyherbal formulation in Wistar rats". Archives of Medicine and Health Sciences. 1 (2 ... Schläppi B (1984). "The lack of hepatotoxicity in the rat with the new and reversible MAO-A inhibitor moclobemide in contrast ... 2015) Antioxidant Activity of The Ancient Herb, Holy Basil in CCl4-Induced Liver Injury in Rats. Ayurvedic 2: 34-38. Ravi V, ...
leaves in female Wistar rats". Journal of Integrative Medicine. 14 (5): 400-408. doi:10.1016/S2095-4964(16)60271-6. Timbers 2. ...
1954 Norwegian pathologist Reidar Eker bred a line of Wistar rats predisposed to renal adenomas. The Eker rat became an ... 1994 The Eker rat was discovered to be an animal model for tuberous sclerosis; it has a mutation in the rat-equivalent of the ... Eker R (1954). "Familial renal adenomas in Wistar rats; a preliminary report". Acta Pathologica et Microbiologica Scandinavica ... In the 1980s, Knudson's studies on the Eker rat strengthened this hypothesis. 1975 Giuseppe Pampiglione and E. Pugh, in a ...
She was involved in breeding the Wistar lab rat, a strain of rats genetically homogeneous albinos intended for use in ... King participated in breeding the Wistar rat, a strain of genetically homogeneous albino rats for use in biological and medical ... Clause, Bonnie Tocher (Summer 1993). "The Wistar Rat as a Right Choice: Establishing Mammalian Standards and the Ideal of a ... Clause, B. T. (February 1998). "The Wistar Institute Archives: Rats (Not Mice) and History". Mendel Newsletter (7): 2-7. PMID ...
Beldia) on small-intestinal disaccharidase activity in Wistar rats". Toxicology Reports. 5: 46-55. doi:10.1016/j.toxrep.2017.12 ...
Singh ND; Sharma AK; Dwivedi P; Patil RD; Kumar M (2007). "Citrinin and endosulfan induced teratogenic effects in Wistar rats ... though it has significant teratogenic effects in laboratory rats. A 2009 assessment concluded the endocrine disruption in rats ... The US EPA classifies it as Category I: "Highly Acutely Toxic" based on a LD50 value of 30 mg/kg for female rats, while the ... and that developmental or reproductive toxicity in rats occurs only at endosulfan doses that cause neurotoxicity. Endosulfan is ...
"Immunotoxicity of ethyl-4-isothiocyanatobutanoate in male Wistar rats". Toxicology. 145 (2-3): 217-25. doi:10.1016/S0300-483X( ... "Immunotoxic and cancerostatic effects of ethyl-4-isothiocyanatobutanoate in female Lewis rats with implanted fibrosarcoma". ...
Kart-Teke E, De Souza Silva MA, Huston JP, Dere E (March 2006). "Wistar rats show episodic-like memory for unique experiences ... Other studies have demonstrated this type of memory in different animal species, such as dogs, rats, honey bees, and primates. ... Eacott MJ, Easton A, Zinkivskay A (2005). "Recollection in an episodic-like memory task in the rat". Learning & Memory. 12 (3 ...
"Mobile phone usage and male infertility in Wistar rats". Indian Journal of Experimental Biology. 48 (10): 987-92. PMID 21299041 ... There was also some evidence of tumors in the brain and adrenal gland of exposed male rats. For female rats, and male and ... This report concludes after the review with an updated statement that "there is clear evidence that male rats exposed to high ... "High Exposure to Radio Frequency Radiation Associated With Cancer in Male Rats". NIEHS;.NIH.gov. National Toxicology Program, ...
"The developmental toxicity of 2-ethylhexanoic acid in Wistar rats". Fundamental and Applied Toxicology. 19 (4): 505-511. doi: ... 2-Ethylhexanol exhibits low toxicity in animal models, with LD50 ranging from 2-3 g/kg (rat). 2-Ethylhexanol has been ... Eastman Kodak Company, Eastman Kodak (2009-03-15). "Pharmacokinetic studies with 2-ethylhexanol in the female fischer 344 rat ( ... "Metabolism of 2-ethylhexanol administered orally and dermally to the female Fischer-344 rat". hero.epa.gov. Archived from the ...
"Prenatal developmental toxicity study of n-heneicosane in Wistar rats". Toxicology and Industrial Health. 32 (1): 118-25. doi: ... geraniol and citronellol on rat ileum contraction". Research in Pharmaceutical Sciences. 8 (1): 17-23. PMC 3895296. PMID ...
"Inhalation carcinogenicity study with nickel metal powder in Wistar rats". Toxicology and Applied Pharmacology. 233 (2): 262-75 ...
Alston roots against paracetamol-induced hepatotoxicity in Albino Wistar rats". Journal of Pharmacy Research. 7 (6): 496-501. ...
Stem Bark Extract on Hematological and Biochemical Parameters of Wistar Rats". Biochemistry Insights. 9: 19-22. doi:10.4137/BCI ...
... of Wistar Rats Revised by Edmyr Rosa dos Reis, et al. (Articles with short description, Short description ...
The SHR strain was obtained during the 1960s by Okamoto and colleagues, who started breeding Wistar-Kyoto rats with high blood ... Transplanting a kidney from SHR to a normotensive Wistar rat increases blood pressure in the recipient. Conversely, ... Spontaneously hypertensive rat (SHR) is a laboratory rat which is an animal model of essential (or primary) hypertension, used ... Animal models of ischemic stroke Pinto YM, Paul M, Ganten D (July 1998). "Lessons from rat models of hypertension: from ...
... and C57BL/6N mice and Wistar rats (mammals) via the PGP gene product. Caparrós-Martín JA, McCarthy-Suárez I, Culiáñez-Macià FA ...
... a 52-week dietary toxicity study in Wistar rats]". Shokuhin Eiseigaku Zasshi. Journal of the Food Hygienic Society of Japan. 45 ... However, its antidiabetic properties were not confirmed in rats. Reduction of sugar intake: G. sylvestre extracts taken in the ... "Absence of antidiabetic and hypolipidemic effect of Gymnema sylvestre in non-diabetic and alloxan-diabetic rats". Braz. Arch. ...
"Studies on the antilithic effect of Rotula aquatica Lour in male Wistar rats". Methods and Findings in Experimental and ...
... and wistar rat. Australian Journal of Zoology 30: 865-875. Orsi, M.A., Ferreira, A.L., de Melo, V.R. & Oliveira, M.C. (1981). ... Reid, B.L. & Cleland, K.W. (1957). The structure and function of the epididymis I. The histology of the rat epididymis. ... I. Temperature and androgen as determinants of the sperm storage capacity of the rat cauda epididymidis. Biology of ... rat) are respectively 4% and 8% of the total length of the duct. Significantly, the low intra-abdominal sperm storage capacity ...
"Thiazolidinedione Treatment Prevents Free Fatty Acid-Induced Insulin Resistance in Male Wistar Rats". Diabetes. 50 (10): 2316- ... Retracted) Hevener, A.; Reichart, D.; Janez, A.; Olefsky, J. (2002). "Female Rats Do Not Exhibit Free Fatty Acid-Induced ...
Water extracts of I. aquatica showed a blood sugar-lowering effect in Wistar rats. An aqueous juice of 100g plant material was ...
... suppresses ethanol preference in chronically alcoholized Wistar rats". Alcohol. 39 (3): 125-34. doi:10.1016/j.alcohol.2006.08. ... on alcohol intake and motivational properties of alcohol in alcohol-preferring sP rats". Alcohol and Alcoholism. 40 (1): 46-53 ... somatic growth and metabolic parameters in rats". Neuropharmacology. 54 (1): 194-205. doi:10.1016/j.neuropharm.2007.07.004. ...
"Phenobarbital blocks the lung edema induced by centrally injected tityustoxin in adult Wistar rats". Neuroscience Letters. 332 ... In rats, the Tityustoxin caused dramatic effects on the circulatory and respiratory systems, consisting of hypotension, ... in the rat". Toxicon. 15 (3): 225-234. doi:10.1016/0041-0101(77)90048-4. PMID 867438. Mesquita, Michel Bernanos Soares; Moraes- ... tityustoxin and toxin Ts-γ from Tityus serrulatus scorpion on secretion and structure of the rat submandibular gland". Archives ...
"Chelidonium majus is not hepatotoxic in Wistar rats, in a 4 weeks feeding experiment". Journal of Ethnopharmacology. 126 (3): ... Sanguinarine is particularly toxic with an LD50 of 18 mg per kg body weight (IP in rats). Caffeic acid derivatives, such as ...
3.5% of a dose of dichloroacetylene remains in the corpses of male Wistar rats. The LD50s of mice exposed to dichloroacetylene ... Studies on male rats and rabbits have shown that inhalation of dichloroacetylene can cause tubular necrosis, focal necrosis, ... Inhalation of dichloroacetylene also causes benign tumors of the livers and kidneys of rats. The chemical also caused increased ... While dichloroacetylene is nephrotoxic in rats, it does not show any signs of nephrotoxicity in humans. Dichloroacetylene has ...
de Cássia da Silveira E Sá R, de Oliveira Guerra M (July 2007). "Reproductive toxicity of lapachol in adult male Wistar rats ... Tropical Woods (1925), 1 7-9. Felício AC, Chang CV, Brandão MA, Peters VM, Guerra Mde O (October 2002). "Fetal growth in rats ... Guerra Mde O, Mazoni AS, Brandão MA, Peters VM (February 2001). "Toxicology of Lapachol in rats: embryolethality". Brazilian ...
de Cássia da Silveira E, Sá R, de Oliveira Guerra M (2007). "Reproductive toxicity of lapachol in adult male Wistar rats ... Guerra Mde O, Mazoni AS, Brandão MA, Peters VM (2001). "Toxicology of Lapachol in rats: embryolethality". Brazilian Journal of ... "Fetal growth in rats treated with lapachol". Contraception. 66 (4): 289-93. doi:10.1016/S0010-7824(02)00356-6. PMID 12413627. ...
de Cássia da Silveira E, Sá R, de Oliveira Guerra M (2007). "Reproductive toxicity of lapachol in adult male Wistar rats ... Felício AC, Chang CV, Brandão MA, Peters VM, Guerra Mde O (2002). "Fetal growth in rats treated with lapachol". Contraception. ... Guerra Mde O, Mazoni AS, Brandão MA, Peters VM (2001). "Toxicology of Lapachol in rats: embryolethality". Brazilian Journal of ... ingredients such as lapachol have been found to possess significant abortifacient and reproductive toxicity effects for rats. ...
The 10-day LD50 in Wistar rats is 166 mg/kg in males, 120 mg/kg in females, and 60-65 mg/kg for ip. administration in males. ... Rats fed 5-10 mg/kg of sterigmatocystin for two years showed a 90% incidence of liver tumours. It has been suggested that ... Chronic symptoms include induction of hepatomas in rats, pulmonary tumours in mice, renal lesions and alterations in the liver ... Skin and hepatic tumours are induced in rats by dermal application. Cattle exhibiting bloody diarrhoea, loss of milk production ...
This analysis yielded the conclusion that, in their culture of Wistar rat neocortical cells, the AWSR has long rise and fall ... Studies commonly employ rat cortical, hippocampal, and spinal neurons, although lab mouse neurons have also been used. ... Because of their wide availability, neuronal networks are typically cultured from dissociated rat neurons. ...
Lewis rats show more compulsive lever pressing behavior than Sprague Dawley or Wistar rats and are less responsive to the anti- ... Rats are unable to vomit when they ingest a substance that is harmful thus pica in rats is analogous to vomiting in other ... Also, if rats are restricted both in food intake and wheel access, they will adjust accordingly. In fact, if rats are first ... Rats became significantly more tolerant to morphine when they had been exposed to a paired administration than those rats that ...
The Sprague Dawley rat and Long-Evans rat were developed from Wistar rats. Wistar rats are more active than others like Sprague ... The spontaneously hypertensive rat and the Lewis rat are other well-known stocks developed from Wistar rats. The Long-Evans rat ... The Wistar rat is an outbred albino rat. This breed was developed at the Wistar Institute in 1906 for use in biological and ... Shaking rat Kawasaki was first described in 1988. This and the Lewis rat are well-known stocks developed from Wistar rats. The ...
... is somewhat different from the more selective Type I myofiber atrophy observed in unloaded Sprague-Dawley and Wistar rat muscle ... The center of gravity in rats is much lower than normal. They no longer support their body weight and initiate movement off the ... To our knowledge the only other species besides the rat that has been involved in spaceflight studies on skeletal muscle is the ... McDonald, KS; Delp, MD; Fitts, RH (June 1992). "Effect of hindlimb unweighting on tissue blood flow in the rat". Journal of ...
In Wistar rats with gravitational cerebral ischemia, Phenylpiracetam reduced the extent of neuralgic deficiency manifestations ... as much non-preferred rat chow than control rats; rats given 10 mg/kg Methylphenidate performed 170% as much work and consumed ... In tests against a control, Sprague-Dawley rats given free access to less-preferred rat chow and trained to operate a lever ... Rats 1 mg/kg amphetamine performed an average of 150% as much work and consumed 50% ...
The joint United States/Soviet Union experiments were conducted on 2 rhesus monkeys and 10 male Wistar rats. The biological ... Structural Changes and Cell Turnover in the Rats Small Intestine: The objective of this experiment was to determine the ... Hepatic Function in Rats After Space Flight: The objective of this experiment was to determine the effect of microgravity on ... Rat Testis Morphology and Physiology: The objective of this experiment was to determine the effects of microgravity on rodent ...
Chang, (2006). Thirteen-week oral (gavage) toxicity of meso-zeaxanthin in Han Wistar rats with a 4-week recovery. Bone, RA; ...
Ten pregnant female Wistar rats (Rattus norvegicus) were flown. Ground control groups contained the same number of rats. At the ... The rats subsequently produced normal litters. Experiments focused on the effect of weightlessness on various physiological ... Additionally eighteen pregnant white rats were sent to be used for studies of the effects of microgravity and radiation. ... Two monkeys flew on the mission, together with several pregnant rats. More than 60 experiments were performed by investigators ...
Perez-D'Gregorio RE, Miller RK, Baggs RB (1988). "Maternal toxicity and teratogenicity of tellurium dioxide in the Wistar rat: ...
However, the first phase of REACH testing has shown that the oral LD50 value of MMF in Wistar rats was established to exceed ...
"Synthesis and study the analgesic effects of new analogues of ketamine on female wistar rats". Medicinal Chemistry. 8 (2): 246- ... Harvey M, Sleigh J, Voss L, Pruijn F, Jose J, Gamage S, Denny W (2015). "Determination of the Hypnotic Potency in Rats of the ... in rat urine using gas chromatography-mass spectrometry". Journal of Chromatography A. 1186 (1-2): 380-90. doi:10.1016/j.chroma ... chemical synthesis and pain perception in rats". Pharmacology, Biochemistry, and Behavior. 98 (2): 227-33. doi:10.1016/j.pbb. ...
... and susceptible Wistar Kyoto (WKY) rats. Resistant F344 rats crossed with non-resistant WKY rats produce subcongenic strains, ... In addition to rats, cattle and humans also show increased ZIP12 protein when housed in hypoxic environments, which implies ... A ZIP12 frameshift mutation in F344 rats truncates the protein and reduces cellular zinc uptake by pulmonary endothelial smooth ... identified ZIP12 as the responsible gene through congenic breeding between Fisher 344 (F344) rats, which are resistant to ...
After one to three further passages on rats, the vaccine was deemed safe for human use. On 27 February 1950, Koprowski's live, ... Also working at Lederle was Polish-born virologist and immunologist Hilary Koprowski of the Wistar Institute in Philadelphia, ...
... rats and donkeys. A recent study that compared different formulations and concentrations of the ethanolic extract from Jucá ( ... em ratos Wistar". Brazilian Journal of Veterinary Research and Animal Science. 52 (1): 34. doi:10.11606/issn.1678-4456.v52i1p34 ...
Druce ameliorates Cisplatin therapy-induced partial testicular atrophy in male Wistar rats". Journal of Ethnopharmacology. 261 ...
Koprowski served as director of the Wistar Institute, 1957-91, during which period Wistar achieved international recognition ... Koprowski developed his polio vaccine by attenuating the virus in brain cells of a cotton rat, Sigmodon hispidus, a New World ... The group developed the HDCV rabies vaccine in the 1960s at the Wistar Institute. It was licensed for use in the United States ... Albert Sabin Discredited HIV/AIDS origins theories Jonas Salk List of Polish people Poles Polio vaccine Wistar Institute ...
"Analgesic and anti-inflammatory effects of aqueous extract of Zea mays husk in male Wistar rats.", NCBI, 13 April 2010. ...
Circulatory effects of carpaine were studied in Wistar male rats weighing 314 +/- 13 g, under pentobarbital (30 mg/kg) ... Hornick, C. A.; Sanders, L. I.; Lin, Y. C. "Effect of carpaine, a papaya alkaloid, on the circulatory function in the rat." ...
This would lead to the production of the Wistar white rat as a standard for research. Donaldson married Julia Desboro Vaux in ... reference tables and data for the albino rat (Mus norvegicus albinus) and the Norway rat (Mus norvegicus) (1915) (Articles with ... In 1905 he moved to the Wistar Institute of Anatomy and Biology at Philadelphia and worked there until his death. Here he began ... After his death, his brain was donated to the collection of the Wistar Institute. Bronk, Detlev W. (1938). "Henry Herbert ...
"Polybrominated diphenyl ethers alter hepatic phosphoenolpyruvate carboxykinase enzyme kinetics in male Wistar rats: ... Kleineke J, Sauer H, Söling HD (January 1973). "On the specificity of the tricarboxylate carrier system in rat liver ... "Inhibition of phosphoenolpyruvate transport via the tricarboxylate and adenine nucleotide carrier systems of rat liver ...
In 1976, Heber-Katz was appointed as the Assistant Professor at the Wistar Institute. In her viral studies, she developed a T- ... in showing that that the same T-cell receptor in mice and rats recognized different antigens to mediate different diseases. In ...
"Hypoglycemic and hypolipidemic effects of the aqueous fresh leaves extract of Clerodendrum capitatum in Wistar rats". J ...
To study the effect of chemical damage on liver cells, Wistar rats were treated with carbon tetrachloride for 48 hours prior to ... In the rat embryo, perlecan expression has been shown to increase in vascular smooth muscle cells (VSMCs) post e19 in fetal ... This is not in contrast to the data shown where perlecan expression is constant beyond e19 in rat VSMC, which suggested that ... Key B, Treloar HB, Wangerek L, Ford MD, Nurcombe V (March 1996). "Expression and localization of FGF-1 in the developing rat ...
... but the different metabolites have been examined in Wistar rats. After administration of dimethocaine, different metabolites ... studies on its in-vivo metabolism and its detectability in urine by means of a rat model and liquid chromatography-linear ion- ...
For,i, in vivo ,/i,studies, 25 Wistar rats were used: normal control, negative control, treatment groups with crude and ... of Indonesian fermented food was capable of degrading thrombus induced in Wistar rats. ... Originated from Indonesian Soybean-Based Fermented Food on Wistar Rats. Florensia Nailufar. ,1,2Raymond R. Tjandrawinata. ,1,2 ... Twenty-five male rats (Rattus norvegicus), stock Wistar, weighing 300-400 grams were acclimatized for 7 days in an ...
Pharmacognosy Research (Pharmacogn Res.). [ISSN: Print -0976-4836, Online - 0974-8490] [http://www.phcogres.com], It provides peer-reviewed original research articles from the field of Natural Products. The journal serves an international audience of scientists and researchers in a variety of research and academia by quickly disseminating research findings related to Medicinal Plants and Natural Products.. It is a peer reviewed journal aiming to publish high quality original research articles, methods, techniques and evaluation reports, critical reviews, short communications, commentaries and editorials of all aspects of medicinal plant research. The journal is aimed at a broad readership, publishing articles on all aspects of pharmacognosy, and related fields. The journal aims to increase understanding of pharmacognosy as well as to direct and foster further research through the dissemination of scientific information by the publication of manuscripts. The submissions of original contributions ...
Methods: Adult female Wistar rats were implanted with microdialysis probes in the pVTA. During microdialysis, rats received ... Methods: Adult female Wistar rats were implanted with microdialysis probes in the pVTA. During microdialysis, rats received ... Methods: Adult female Wistar rats were implanted with microdialysis probes in the pVTA. During microdialysis, rats received ... Methods: Adult female Wistar rats were implanted with microdialysis probes in the pVTA. During microdialysis, rats received ...
TOMANARI, Gerson Yukio; PINE, Alexandre de Souza y SILVA, Maria Teresa Araújo. Wistar rats under water and food restriction. ... Palabras clave : Wistar rats; Water restriction; Food restriction; Body weight. · resumen en Portugués · texto en Portugués · ... Subjects were 29 Wistar rats bred at the Experimental Psychology Department Animal House. They were weighed daily from Day 5 to ... The data illustrate the general pattern of body mass acquisition in rats, in the presence and absence of water or food ...
Twenty adult male Wistar rats were divided into two groups. The control animals were not infected. The experimental animals ... The present research aims to examine a periodontal disease model in which specific pathogen-free Wistar rats are orally exposed ... Periodontal disease induced by Porphyromonasgingivalis and Fusobacterium nucleatum in Wistar rats. Arq. Odontol. [online]. 2010 ... Keywords : Rats; Periodontitis; Bone resorption; Porphyromonas gingivalis; Fusobacterium nucleatum. · abstract in Portuguese · ...
Previous short-term use of testosterone propionate enhances muscle hypertrophy in Wistar rats submitted to ladder-based ... on the morphology of the gastrocnemius muscle of Wistar rats submitted to ladder-based resistance training (LRT). Twenty-eight ... training can elicit a greater N/f ratio and size of the mean fCSA of the Gastrocnemius muscle of young adult Wistar rats than ... Previous short-term use of testosterone propionate enhances muscle hypertrophy in Wistar r ...
Return to Article Details Screening of antidepressant activity of marsilea minuta in wistar albino rats Download Download PDF ...
Return to Article Details Attenuation of Paraquat-Induced Nephrotoxicity and Dysfunction in Male Wistar Albino Rats Download ...
Twenty male wistar rats were randomized according to body weight into four groups of five rats each and treated as follows : a ... Aqueous extract of Cola anomala nuts protects against metabolic disorders in albino Wistar rats. juillet 6, 2022 webmaster ... Aqueous extract of Cola anomala nuts protects against metabolic disorders in albino Wistar rats ...
Vernacular names [edit wikidata brown rat] *. English. : Brown Rat, Norway rat, common rat. ...
... Alternative title. Efeitos ... MATERIALS AND METHODS: Thirty-day-old male Wistar rats (70-100 g) were distributed into four groups: normal-diet (NC), chronic ... Effects of chronic stress and high-fat diet on metabolic and nutritional parameters in Wistar rats. Arquivos Brasileiros de ... OBJECTIVE: The aim of this study was assess the role of chronic stress on the metabolic and nutritional profile of rats exposed ...
Materials and Methods: Thirty Wistar rats were divided into five groups (n = 6). Group 1 was the control and Group 2 (ADR) ... and attenuates cardio-inflammatory responses in adrenaline-augmented myocardial injury in rats. ... This study investigated the effect of vitamin C on some gastric parameters in myocardial injury in rats. ... Materials and Methods: Thirty Wistar rats were divided into five groups (n = 6). Group 1 was the control and Group 2 (ADR) ...
HISTOLOGICAL VARIANCES OF MORINGA OLIFERA ON THE KIDNEY OF ADULT WISTAR RATS Authors. * ADETUNJI OPEYEMI ADEBOLA Department of ... Methods: Twenty (20) adult Wistar rats (both sex) were used for the study (caged based on same sex to avoid mating and ... HISTOLOGICAL VARIANCES OF MORINGA OLIFERA ON THE KIDNEY OF ADULT WISTAR RATS. Innovare Journal of Medical Sciences, 9(3), 36-38 ... AND BENZENE-INDUCED ACINAR CELLS DAMAGE IN ADULT WISTAR RATS , Innovare Journal of Medical Sciences: Vol 10 Issue 2 2022 (Mar- ...
Sprague-Dawley rats (lungs) 2/501 208/501 IFA Seoul, Korea Wistar rats (lungs) 1/480 165/480 IFA ... Other isolations: laboratory rat, 1 Japan (25); laboratory rat tumor, 1 Japan (26); Rattus nitidus 1 China (27); Bandicota ... It has not been established that the bandicoot rat isolate is identical to other rat isolates or to Hantaan virus. ... Clinically severe and moderate hospitalized cases in Seoul City where only urban rats were found. The patients have never been ...
Rats * Rats, Wistar * Schwann Cells / physiology * Schwann Cells / ultrastructure* Substances * Antibodies, Monoclonal ...
Some studies on Campylobacter jejuni in Sprague Dawley and Wistar female rats / by Mbaruk A. Suleman. By: Suleman, Mbaruk A ... Details for: Some studies on Campylobacter jejuni in Sprague Dawley and Wistar female rats / ... TextPublication details: 1986. Description: 37 leavesSubject(s): Campylobacter fetus , Rats, Inbred strains , Dissertations, ...
... on the blood and organs of albino Wistar rats. This study was carried out on 20 mature Wistar rats, randomly divided into four ... Biochemical and hematological assays, of the blood samples show that the addition of tartrazine in the diet of rats caused ... From: Protective effect of blackthorn fruits (Prunus spinosa) against tartrazine toxicity development in albino Wistar rats ... Table 2 Average values and standard deviation for hematological measurements of Wistar rats treated with tartrazine for 7 weeks ...
48 male wistar rats Beetroot juice delivered by gavage (8 mL∙kg∙bm∙day−1; ≈1.92 mL∙day−1). 23.5 μmol Trolox equivalents∙mL−1. ... 48 albino wistar rats Beetroot pomace extract delivered intraperitoneally (1-3 mL∙kg∙bm∙day−1; ≈0.2-0.6 ml∙day−1). N/A. 7 days ... 24 male wistar rats. Beetroot juice delivered by gavage (8 mL∙kg∙bm∙day−1). N/A. 28 days. Intraperitoneal injection of NDEA ( ... 24 albino wistar rats. Extracts of fresh beetroot delivered orally (250 and 500 mg∙kg∙bm∙day−1; ≈45-90 mg∙day−1). 90.1% radical ...
Stem Bark in Alloxan-induced Type 1 Diabetic Female Wistar Rats ...
... This study used twenty-five male Wistar rats divided into five groups: positive control (Bioplacenton®), negative control ( ... Nasrabadi, M.H., Ebrahimi, M.T., Banadaki, S.D., Kajousangi, M.T. & Zahedi, F., 2011, Study of Cutaneous Wound Healing in Rats ... Seed Topically to The Level of Cuts Recovery on White Rats Sprague dawley Strain, J. Majority, 3, 26-35. ...
Administration of Kaempferia galanga Rhizome Extract and Simvastatin in Improving Lipid Profile of Dyslipidemic Male Wistar ... Methods: An experimental study with a randomized pretest-posttest control group design was conducted on 14 male Wistar rats, ... study aimed to determine the effect of Kaempferia galanga rhizome extract on improving the lipid profile of male Wistar rats ... of Kaempferia galanga Rhizome Extract and Simvastatin in Improving Lipid Profile of Dyslipidemic Male Wistar Rats. Journal: ...
We determined, in normal-weight male Wistar rats, if the source of VTA NPY is local, and/or whether it is derived from VTA- ... Afferent Neuropeptide Y projections to the ventral tegmental area in normal-weight male Wistar rats. ... Afferent Neuropeptide Y projections to the ventral tegmental area in normal-weight male Wistar rats. ... VTA NPY originates from the hypothalamic Arc and the ventrolateral medulla of the brainstem in normal-weight male Wistar rats. ...
... and histological alterations induced by chronic aluminum chloride administration in wistar rats. / Shaik, Arshad; Shenoy, Smita ... and histological alterations induced by chronic aluminum chloride administration in wistar rats. Journal of Pharmacology and ... and histological alterations induced by chronic aluminum chloride administration in wistar rats. In: Journal of Pharmacology ... and histological alterations induced by chronic aluminum chloride administration in wistar rats, Journal of Pharmacology and ...
Details Antihyperlipidemic Property of a Dietary Supplement of Moringa Oleifera Leaves and Pleurotus Ostreatus in Wistar Rats ...
In vivo Antisalmonellal and Antioxidant Activity of Hydroethanolic Extract of Bauhinia rufescens Leaves in Wistar Albino Rats ... In vivo Antisalmonellal and Antioxidant Activity of Hydroethanolic Extract of Bauhinia rufescens Leaves in Wistar Albino Rats ... in rats experimentally infected with Salmonella Typhi ATCC6539, as an alternative therapy. Methods: The rats were randomly ...
Toxicokinetics of p-tert-octylphenol in male Wistar rats. Arch Toxicol 1996;71(1-2):112-22. ... Bian Q, Qian J, Xu L, Chen J, Song L, Wang X. The toxic effects of 4-tert-octylphenol on the reproductive system of male rats. ... Nagao T, Yoshimura S, Saito Y, Nakagomi M, Usumi K, Ono H. Reproductive effects in male and female rats from neonatal exposure ... Effects of 4-tert-octylphenol given in drinking water for 4 months on the male reproductive system of Fischer 344 rats. Reprod ...
rat. Strain:. Wistar. Sex:. male. Route of administration:. inhalation. Vehicle:. not applicable. Details on exposure:. Rats ... Male Wistar rats were exposed to 0.5 and 1 mg/cm³ dimethylamine via continuous inhalation for 15 and 90 days. 50 to 100 bone ... DMA was investigated on male Wistar rats weighing 150-200 g. These were subjected to long-term poisning by inhalation in 100- ... In an in Vivo Mammalian Chromosome Aberration Assay (Isakova et al., 1971), Wistar rats were exposed to vapours of DMA by ...
The first rat survived; hence the four additional female Wistar rats each received a single dose of 2000 mg/kg body weight ... The first rat survived; hence the four additional female Wistar rats each received a single dose of 2000 mg/kg body weight ... rat. Strain:. Wistar. Sex:. female. Details on test animals or test system and environmental conditions:. Age: 10 - 12 weeks. ... An acute oral toxicity study (Up-and-Down Procedure) was conducted using five female Wistar rats given a single oral dose of ...
  • Some studies on Campylobacter jejuni in Sprague Dawley and Wistar female rats / by Mbaruk A. Suleman. (who.int)
  • Voss C, Zerban H, Bannasch P, Berger MR. Lifelong exposure to di-(2-ethylhexyl)-phthalate induces tumors in liver and testes of Sprague-Dawley rats. (who.int)
  • MATERIAIS E MÉTODOS: Ratos Wistar machos (30 dias de idade/70-100 g) foram distribuídos em quatro grupos: dieta-normal (NC), estresse crônico (St), dieta rica em gordura (HD) e estresse crônico/dieta rica em gordura (HD/St). O estresse consistiu em imobilização durante 15 semanas, 5 vezes por semana 1h por dia e a dieta rica em gordura foi oferecida por 15 semanas. (unesp.br)
  • Inicialmente foi realizado um ensaio biológico com ratos Wistar. (usp.br)
  • A strain of albino rat developed at the Wistar Institute that has spread widely at other institutions. (bvsalud.org)
  • This study investigated the effect of vitamin C on some gastric parameters in myocardial injury in rats. (ac.ir)
  • Effects of aqueous extract of Mangifera indica L. (Mango) Stem bark on haematological parameters of normal albino rats. (innovareacademics.in)
  • For in vivo studies, 25 Wistar rats were used: normal control, negative control, treatment groups with crude and semipurified enzyme given orally at 25 mg/kg, and positive control group which received Lumbrokinase at 25 mg/kg. (hindawi.com)
  • The present research aims to examine a periodontal disease model in which specific pathogen-free Wistar rats are orally exposed to Porphyromonas gingivalis associated with Fusobacterium nucleatum . (bvsalud.org)
  • 2004).In rats, orally administered 4- tert -octylphenol was well absorbed, did not bioaccumulate, and was quickly eliminated from the blood (Certa et al. (cdc.gov)
  • Twenty adult male Wistar rats were divided into two groups. (bvsalud.org)
  • Twenty-eight rats were divided equally into groups initial control (CI), 4-week TP (CT4), 4-week TP + LRT (TRT), and placebo + LRT (RT). (bvsalud.org)
  • 0.05) to the control group after MO administration, the organ (Kidneys) shows a significant difference between the kidneys (left and right kidneys) in relation to the control group rats. (innovareacademics.in)
  • 0.05) lowered in rats who received AlCl 3 along with either rivastigmine or escitalopram. (manipal.edu)
  • Objective: This work aims to evaluate the in vivo antisalmonellal and antioxidant activity of the 95% hydroethanolic extract of the leaves of Bauhinia rufescens (Fabaceae) in rats experimentally infected with Salmonella Typhi ATCC6539, as an alternative therapy. (who.int)
  • To further investigate the potential susceptibility of rats to infection with human HEV, we experimentally injected nude rats with G3 HEV and monitored virus growth. (cdc.gov)
  • Methods: Adult female Wistar rats were implanted with microdialysis probes in the pVTA. (elsevier.com)
  • Methods: An experimental study with a randomized pretest-posttest control group design was conducted on 14 male Wistar rats, aged 2-2.5 months which suffered from dyslipidemia. (researchbib.com)
  • Materials and Methods: Thirty rats were used. (manipal.edu)
  • Methods: The rats were randomly divided into twelve groups (six per sex) of animals. (who.int)
  • Chronic administration of the environmental pollutant 4- tert -octylphenol to adult male rats interferes with the secretion of luteinizing hormone,follicle-stimulating hormone, prolactin, and testosterone. (cdc.gov)
  • All rats on the study were subject to a gross pathological examination consisting of an external examination and opening of abdominal and thoracic cavities. (europa.eu)
  • and injection of Wistar-rats in the thoracic cavity with asbestos samples to study the carcinogenesis of asbestos fibers as related to surface chemistry. (cdc.gov)
  • OBJECTIVE: The aim of this study was assess the role of chronic stress on the metabolic and nutritional profile of rats exposed to a high-fat diet. (unesp.br)
  • Multigenerational effects of dietary macronutrient intake on the metabolic phenotype of male Wistar rats. (cdc.gov)
  • Rats were observed for toxicity and mortality at 0.5, 1, 2, 3, 4, and 6 hours post dosing, and then twice daily for the remainder of the 14 day observation period. (europa.eu)
  • An acute oral toxicity study (Up-and-Down Procedure) was conducted using five female Wistar rats given a single oral dose of the test material (Undiluted, as received). (europa.eu)
  • Combined Repeated Dose Toxicity Study with the Reproduction/Developmental Toxicity Screening Test in Wistar Rats with (Confidential). (epa.gov)
  • This study aimed to determine the effect of Kaempferia galanga rhizome extract on improving the lipid profile of male Wistar rats with dyslipidemia. (researchbib.com)
  • We determined, in normal-weight male Wistar rats, if the source of VTA NPY is local, and/or whether it is derived from VTA-projecting neurons. (nin.nl)
  • Thus, VTA NPY originates from the hypothalamic Arc and the ventrolateral medulla of the brainstem in normal-weight male Wistar rats. (nin.nl)
  • Bian Q, Qian J, Xu L, Chen J, Song L, Wang X. The toxic effects of 4- tert -octylphenol on the reproductive system of male rats. (cdc.gov)
  • For example, anti-HEV IgG has been detected in various rat species, including Norway ( Rattus norvegicus ), black ( Rattus rattus ), and cotton ( Sigmodon hispidus ) rats, by using ELISA with antigens derived from G1 HEV. (cdc.gov)
  • Subjects were 29 Wistar rats bred at the Experimental Psychology Department Animal House. (bvsalud.org)
  • During microdialysis, rats received acute intraperitoneal (i.p.) injection of saline or EtOH (0.5, 1.0, or 2.0g/kg), and extracellular glutamate levels were measured in the pVTA. (elsevier.com)
  • The highest level at which no acute airway irritation as based on both breathing pattern and frequency was observed in both rat strains was 14 mg/m3. (cdc.gov)
  • All rats were negative for G3 HEV RNA and anti-HEV antibodies, as determined by nested reverse transcription PCR ( 10 ) and ELISA ( 8 ), respectively. (cdc.gov)
  • The rats from the CT4 and TRT groups were treated with TP for four weeks (10 mg/kg/week). (bvsalud.org)
  • Thirty Wistar rats were divided into five groups (n = 6). (ac.ir)
  • The 6 rats were randomly assigned to 2 groups, injected intravenously with 500 µL of an HEV sample suspension through the tail vein, and monitored for 3 months. (cdc.gov)
  • The aim of the present study was to investigate systematically the body weight development of rats submitted to controlled water or food restriction for about 7 months, as compared to animals under an ad Lib regimen. (bvsalud.org)
  • Prior studies have shown that it is necessary to place ligatures around molars to study periodontal destruction in rats. (bvsalud.org)
  • Our study showed that four weeks following infection with Porphyromonas gingivalis and Fusobacterium nucleatum bone loss in Wistar rats could be identified. (bvsalud.org)
  • At study termination, all rats were humanely euthanised by carbon dioxide asphyxiation. (europa.eu)
  • Comparative metabolism study of ß-lapachone in mouse, rat, dog, monkey, and human liver microsomes using liquid chromatography-tandem mass spectrometry. (medlineplus.gov)
  • recently reported that G1, G2, and G3 do not infect laboratory rats ( 7 ), and we found in a previous study that laboratory rats are not susceptible to G1, G3, or G4 HEV ( 8 ). (cdc.gov)
  • In BN rats, changes in breathing pat- tern were seen at levels of 29 mg/m3 and higher and decreases in frequency at 60 mg/m3 and higher, whereas in Wistar rats changes in both pattern and frequency (increases fol- lowed by decreases) were seen at levels of 34 mg/m3 and higher. (cdc.gov)
  • also reported that human HEV (presumably G1) was transmissible to Wistar laboratory rats ( 6 ). (cdc.gov)
  • View of Antihyperlipidemic Property of a Dietary Supplement of Moringa Oleifera Leaves and Pleurotus Ostreatus in Wistar Rats Stressed by Combination of Ethanol-Paracetamol. (medicalresearchjournal.org)
  • Djenguemtar J, Goka M. S. C, Noubom M, Konack E. Y, Kamsu G. T, Sokoudjou J. B, Feudjio H. B. L, Kodjio N, Gatsing D.. In vivo Antisalmonellal and Antioxidant Activity of Hydroethanolic Extract of Bauhinia rufescens Leaves in Wistar Albino Rats Infected with Salmonella Typhi. (who.int)
  • Histological sections shows a normal Glomerulli, Peri-Glomerular Space, Convoluted Tubules, and Interstitium, after administration of the Crude Aqueous Extract of MO lame in terms with the control group rats. (innovareacademics.in)
  • To investigate the effects of the previous administration of testosterone propionate (TP) on the morphology of the gastrocnemius muscle of Wistar rats submitted to ladder-based resistance training (LRT). (bvsalud.org)
  • of Indonesian fermented food was capable of degrading thrombus induced in Wistar rats. (hindawi.com)
  • neutralizing antibody titrations indicated that infections were caused by a rat-associated virus(30). (cdc.gov)
  • These results suggest that HEV or HEV-like virus infections occur in wild rats. (cdc.gov)
  • The first rat was given a single dose of 2000 mg/kg body weight. (europa.eu)
  • Therefore, rat N° 2, 3, 4 and 6 were treated with the same dose level of 2000 mg/kg body weight, one at a time, separated by minimum 48 h intervals. (europa.eu)
  • In conclusion, short-term TP administration before resistance training can elicit a greater N/f ratio and size of the mean fCSA of the Gastrocnemius muscle of young adult Wistar rats than resistance training alone. (bvsalud.org)
  • All the studies reported here were performed on rats (Wistar, female). (cdc.gov)
  • The data illustrate the general pattern of body mass acquisition in rats, in the presence and absence of water or food restriction, along a period corresponding to a typical behavioral experiment. (bvsalud.org)
  • ABSTRACT Objective: To analyze wound contraction and histomorphometric pattern of lesions in Wistar rats undergoing doxorubicin extravasation. (bvsalud.org)
  • this finding suggests that wild rats are hosts for G3 HEV. (cdc.gov)
  • the 3 rats in group 2 were injected with the cell culture supernatant sample, which contained 4 × 10 6 copies of G3 HEV. (cdc.gov)
  • Esto ha diluido en gran medida la cepa original. (bvsalud.org)
  • Safety of the bacterial enzyme from the Indonesian fermented Oncom was tested using cell culture and experimental rats, while the effect of Stenotrophomonas enzyme on degrading thrombus was observed using the experimental rats. (hindawi.com)
  • Although rats have long been suspected to be a potential reservoir for human HEV, no direct evidence has been found. (cdc.gov)
  • The susceptibility of rats to human HEV genotypes is controversial. (cdc.gov)
  • Abstract Objective: to evaluate the effect of photobiomodulation with low-level 660 nm laser alone or associated with Human Amniotic Membrane in the repair of partial-thickness burns in rats. (bvsalud.org)
  • Clinically severe and moderate hospitalized cases in Seoul City where only urban rats were found. (cdc.gov)
  • Objective: To assess the effect of duloxetine and escitalopram on aluminum chloride (AlCl3)-induced memory impairment in rats. (manipal.edu)
  • Conclusion: Escitalopram and duloxetine exerted a protective effect against AlCl 3 -induced memory impairment in rats. (manipal.edu)