Rats, Wistar
Rats, Inbred WKY
Disease Models, Animal
Rats, Inbred SHR
Rats, Inbred Strains
Body Weight
Random Allocation
Plant Extracts
Liver
Dose-Response Relationship, Drug
Kidney
Diabetes Mellitus, Experimental
Physical Conditioning, Animal
Species Specificity
Models, Animal
Ethanol
Lipid Peroxidation
Hypertension
Analysis of Variance
Antioxidants
Rats, Inbred BB
Oxidative Stress
Injections, Intraperitoneal
Thiobarbituric Acid Reactive Substances
Reperfusion Injury
Methylnitronitrosoguanidine
Aging
RNA, Messenger
Immunohistochemistry
Epilepsy, Reflex
Streptozocin
Nitric Oxide
Androsterone
Corticosterone
Catalase
Myocardium
Rodent Diseases
Brain
Insulin
Superoxide Dismutase
Aspartate Aminotransferases
Carcinoma 256, Walker
NG-Nitroarginine Methyl Ester
Muscle, Skeletal
Ethylene Glycol
Nitric Oxide Synthase
Central Nervous System Depressants
Protective Agents
Alanine Transaminase
Glucuronosyltransferase
Glutathione Peroxidase
Swimming
Euphorbiaceae
Mesenteric Arteries
Glutathione
Norepinephrine
Diet, Protein-Restricted
Exploratory Behavior
Dietary Fats
Drug Evaluation, Preclinical
Tetragastrin
Carcinogens
Sex differences in the effects of early neocortical injury on neuronal size distribution of the medial geniculate nucleus in the rat are mediated by perinatal gonadal steroids. (1/41636)
Freezing injury to the cortical plate of rats induces cerebrocortical microgyria and, in males but not females, a shift toward greater numbers of small neurons in the medial geniculate nucleus (MGN). The purpose of the current study was to examine a hormonal basis for this sex difference. Cross-sectional neuronal areas of the MGN were measured in male rats, untreated female rats and female rats treated perinatally with testosterone propionate, all of which had received either neonatal cortical freezing or sham injury. Both male and androgenized female rats with microgyria had significantly smaller MGN neurons when compared to their sham-operated counterparts, whereas untreated females with microgyria did not. These differences were also reflected in MGN neuronal size distribution: both male and androgenized female rats with microgyria had more small and fewer large neurons in their MGN in comparison to shams, while there was no difference in MGN neuronal size distribution between lesioned and sham females. These findings suggest that perinatal gonadal steroids mediate the sex difference in thalamic response to induction of microgyria in the rat cortex. (+info)Activation of alveolar macrophages in lung injury associated with experimental acute pancreatitis is mediated by the liver. (2/41636)
OBJECTIVE: To evaluate (1) whether alveolar macrophages are activated as a consequence of acute pancreatitis (AP), (2) the implication of inflammatory factors released by these macrophages in the process of neutrophil migration into the lungs observed in lung injury induced by AP, and (3) the role of the liver in the activation of alveolar macrophages. SUMMARY BACKGROUND DATA: Acute lung injury is the extrapancreatic complication most frequently associated with death and complications in severe AP. Neutrophil infiltration into the lungs seems to be related to the release of systemic and local mediators. The liver and alveolar macrophages are sources of mediators that have been suggested to participate in the lung damage associated with AP. METHODS: Pancreatitis was induced in rats by intraductal administration of 5% sodium taurocholate. The inflammatory process in the lung and the activation of alveolar macrophages were investigated in animals with and without portocaval shunting 3 hours after AP induction. Alveolar macrophages were obtained by bronchoalveolar lavage. The generation of nitric oxide, leukotriene B4, tumor necrosis factor-alpha, and MIP-2 by alveolar macrophages and the chemotactic activity of supernatants of cultured macrophages were evaluated. RESULTS: Pancreatitis was associated with increased infiltration of neutrophils into the lungs 3 hours after induction. This effect was prevented by the portocaval shunt. Alveolar macrophages obtained after induction of pancreatitis generated increased levels of nitric oxide, tumor necrosis factor-alpha, and MIP-2, but not leukotriene B4. In addition, supernatants of these macrophages exhibited a chemotactic activity for neutrophils when instilled into the lungs of unmanipulated animals. All these effects were abolished when portocaval shunting was carried out before induction of pancreatitis. CONCLUSION: Lung damage induced by experimental AP is associated with alveolar macrophage activation. The liver mediates the alveolar macrophage activation in this experimental model. (+info)Examination of the transverse tubular system in living cardiac rat myocytes by 2-photon microscopy and digital image-processing techniques. (3/41636)
The transverse tubular system (t-system) of cardiac muscle is a structure that allows rapid propagation of excitation into the cell interior. Using 2-photon molecular excitation microscopy and digital image-processing methods, we have obtained a comprehensive overview of the t-system of rat ventricular myocytes in living cells. We show that it is possible to quantify the morphology of the t-system in terms of average local tubule diameter, branching pattern, and local abundance of the t-system by immersing living myocytes in a dextran-linked fluorescein solution. Our data suggest that previous electron microscopic examinations of t-system structure have underestimated both the geometric complexity of the t-system morphology and the fraction of cell volume occupied by the t-system (3.6% in this species). About 40% of tubules occur between Z-lines, and the t-tubule diameter is 255+/-0.85 nm (mean+/-SEM). The t-tubules leave the outer surface of the cell in an approximately rectangular array; however, at some points junctions between the t-tubules and the surface membrane are missing. In view of the complexity of the t-system apparent from our images, we propose that the t-system be renamed the "sarcolemmal Z rete." The methods presented here are generally applicable to the quantification of the sarcolemmal Z rete and other structures within cells by fluorescence microscopy in a variety of cell types. (+info)Induction of serotonin transporter by hypoxia in pulmonary vascular smooth muscle cells. Relationship with the mitogenic action of serotonin. (4/41636)
-The increased delivery of serotonin (5-hydroxytryptamine, 5-HT) to the lung aggravates the development of hypoxia-induced pulmonary hypertension in rats, possibly through stimulation of the proliferation of pulmonary artery smooth muscle cells (PA-SMCs). In cultured rat PA-SMCs, 5-HT (10(-8) to 10(-6) mol/L) induced DNA synthesis and potentiated the mitogenic effect of platelet-derived growth factor-BB (10 ng/mL). This effect was dependent on the 5-HT transporter (5-HTT), since it was prevented by the 5-HTT inhibitors fluoxetine (10(-6) mol/L) and paroxetine (10(-7) mol/L), but it was unaltered by ketanserin (10(-6) mol/L), a 5-HT2A receptor antagonist. In PA-SMCs exposed to hypoxia, the levels of 5-HTT mRNA (measured by competitive reverse transcriptase-polymerase chain reaction) increased by 240% within 2 hours, followed by a 3-fold increase in the uptake of [3H]5-HT at 24 hours. Cotransfection of the cells with a construct of human 5-HTT promoter-luciferase gene reporter and of pCMV-beta-galactosidase gene allowed the demonstration that exposure of cells to hypoxia produced a 5.5-fold increase in luciferase activity, with no change in beta-galactosidase activity. The increased expression of 5-HTT in hypoxic cells was associated with a greater mitogenic response to 5-HT (10(-8) to 10(-6) mol/L) in the absence as well as in the presence of platelet-derived growth factor-BB. 5-HTT expression assessed by quantitative reverse transcriptase-polymerase chain reaction and in situ hybridization in the lungs was found to predominate in the media of pulmonary artery, in which a marked increase was noted in rats that had been exposed to hypoxia for 15 days. These data show that in vitro and in vivo exposure to hypoxia induces, via a transcriptional mechanism, 5-HTT expression in PA-SMCs, and that this effect contributes to the stimulatory action of 5-HT on PA-SMC proliferation. In vivo expression of 5-HTT by PA-SMC may play a key role in serotonin-mediated pulmonary vascular remodeling. (+info)Evidence for a vasopressin system in the rat heart. (5/41636)
Traditionally, a hypothalamo-neurohypophysial system is thought to be the exclusive source of arginine vasopressin (AVP), a potent antidiuretic, vasoconstricting, and growth-stimulating neuropeptide. We have identified de novo synthesis of AVP in the heart as well as release of the hormone into the cardiac effluents. Specifically, molecular cloning of sequence tags amplified from isolated, buffer-perfused, and pressure-overloaded rat hearts allowed the detection of cardiac AVP mRNA. Subsequent experiments revealed a prominent induction of AVP mRNA (peak at 120 minutes, 59-fold, P<0. 01 versus baseline) and peptide (peak at 120 minutes, 11-fold, P<0. 01 versus baseline) in these isolated hearts. Newly induced vasopressin peptide was localized most prominently to endothelial cells and vascular smooth muscle cells of arterioles and perivascular tissue using immunohistochemistry. In addition to pressure overload, nitric oxide (NO) participated in these alterations, because inhibition of NO synthase by Nomega-nitro-L-arginine methyl ester markedly depressed cardiac AVP mRNA and peptide induction. Immediate cardiac effects related to cardiac AVP induction in isolated, perfused, pressure-overloaded hearts appeared to be coronary vasoconstriction and impaired relaxation. These functional changes were observed in parallel with AVP induction and largely prevented by addition of a V1 receptor blocker (10(-8) mol/L [deamino-Pen1, O-Me-Tyr2, Arg8]-vasopressin) to the perfusion buffer. Even more interesting, pressure-overloaded, isolated hearts released the peptide into the coronary effluents, offering the potential for systemic actions of AVP from cardiac origin. We conclude that the heart, stressed by acute pressure overload or NO, expresses vasopressin in concentrations sufficient to cause local and potentially systemic effects. (+info)Role of nitric oxide-cGMP pathway in adrenomedullin-induced vasodilation in the rat. (6/41636)
We previously reported that adrenomedullin (AM), a potent vasodilator peptide discovered in pheochromocytoma cells, stimulates nitric oxide (NO) release in the rat kidney. To further investigate whether the NO-cGMP pathway is involved in the mechanisms of AM-induced vasodilation, we examined the effects of E-4021, a cGMP-specific phosphodiesterase inhibitor, on AM-induced vasorelaxation in aortic rings and perfused kidneys isolated from Wistar rats. We also measured NO release from the kidneys using a chemiluminescence assay. AM (10(-10) to 10(-7) mol/L) relaxed the aorta precontracted with phenylephrine in a dose-dependent manner. Denudation of endothelium (E) attenuated the vasodilatory action of AM (10(-7) mol/L AM: intact (E+) -25.7+/-5.2% versus denuded (E-) -7. 8+/-0.6%, P<0.05). On the other hand, pretreatment with 10(-8) mol/L E-4021 augmented AM-induced vasorelaxation in the intact aorta (-49. 0+/-7.9%, P<0.05) but not in the denuded one. E-4021 also enhanced acetylcholine (ACh)-induced vasorelaxation in the rat intact aorta (10(-7) mol/L ACh -36.6+/-8.4% versus 10(-8) mol/L E-4021+10(-7) mol/L ACh -62.7+/-3.1%, P<0.05). In perfused kidneys, AM-induced vasorelaxation was also augmented by preincubation with E-4021 (10(-9) mol/L AM -15.4+/-0.6% versus 10(-8) mol/L E-4021+10(-9) mol/L AM -23.6+/-1.2%, P<0.01). AM significantly increased NO release from rat kidneys (DeltaNO: +11.3+/-0.8 fmol. min-1. g-1 kidney at 10(-9) mol/L AM), which was not affected by E-4021. E-4021 enhanced ACh-induced vasorelaxation (10(-9) mol/L ACh -9.7+/-1.7% versus 10(-8) mol/L E-4021+10(-9) mol/L ACh -18.8+/-2.9%, P<0.01) but did not affect ACh-induced NO release from the kidneys. In the aorta and the kidney, 10(-4) mol/L of NG-nitro-L-arginine methyl ester, an NO synthase inhibitor, and 10(-5) mol/L of methylene blue, a guanylate cyclase inhibitor, reduced the vasodilatory effect of AM. These results suggest that the NO-cGMP pathway is involved in the mechanism of AM-induced vasorelaxation, at least in the rat aorta and kidney. (+info)Developmental synaptic changes increase the range of integrative capabilities of an identified excitatory neocortical connection. (7/41636)
Excitatory synaptic transmission between pyramidal cells and fast-spiking (FS) interneurons of layer V of the motor cortex was investigated in acute slices by using paired recordings at 30 degrees C combined with morphological analysis. The presynaptic and postsynaptic properties at these identified central synapses were compared between 3- and 5-week-old rats. At these two postnatal developmental stages, unitary EPSCs were mediated by the activation of AMPA receptors with fast kinetics at a holding potential of -72 mV. The amplitude distribution analysis of the EPSCs indicates that, at both stages, pyramidal-FS connections consisted of multiple functional release sites. The apparent quantal size obtained by decreasing the external calcium ([Ca2+]e) varied from 11 to 29 pA near resting membrane potential. In young rats, pairs of presynaptic action potentials elicited unitary synaptic responses that displayed paired-pulse depression at all tested frequencies. In older animals, inputs from different pyramidal cells onto the same FS interneuron had different paired-pulse response characteristics and, at most of these connections, a switch from depression to facilitation occurred when decreasing the rate of presynaptic stimulation. The balance between facilitation and depression endows pyramidal-FS connections from 5-week-old animals with wide integrative capabilities and confers unique functional properties to each synapse. (+info)Differential expression of the mRNA for the vanilloid receptor subtype 1 in cells of the adult rat dorsal root and nodose ganglia and its downregulation by axotomy. (8/41636)
Sensitivity to the pungent vanilloid, capsaicin, defines a subpopulation of primary sensory neurons that are mainly polymodal nociceptors. The recently cloned vanilloid receptor subtype 1 (VR1) is activated by capsaicin and noxious heat. Using combined in situ hybridization and histochemical methods, we have characterized in sensory ganglia the expression of VR1 mRNA. We show that this receptor is almost exclusively expressed by neurofilament-negative small- and medium-sized dorsal root ganglion cells. Within this population, VR1 mRNA is detected at widely varying levels in both the NGF receptor (trkA)-positive, peptide-producing cells that elicit neurogenic inflammation and the functionally less characterized glial cell line-derived neurotrophic factor-responsive cells that bind lectin Griffonia simplicifolia isolectin B4 (IB4). Cells without detectable levels of VR1 mRNA are found in both classes. A subpopulation of the IB4-binding cells that produce somatostatin has relatively low levels of VR1 mRNA. A previously uncharacterized population of very small cells that express the receptor tyrosine kinase (RET) and that do not label for trkA or IB4-binding has the highest relative levels of VR1 mRNA. The majority of small visceral sensory neurons of the nodose ganglion also express VR1 mRNA, in conjunction with the BDNF receptor trkB but not trkA. Axotomy results in the downregulation of VR1 mRNA in dorsal root ganglion cells. Our data emphasize the heterogeneity of VR1 mRNA expression by subclasses of small sensory neurons, and this may result in their differential sensitivity to chemical and noxious heat stimuli. Our results also indicate that peripherally derived trophic factors may regulate levels of VR1 mRNA. (+info)1) They share similarities with humans: Many animal species share similar biological and physiological characteristics with humans, making them useful for studying human diseases. For example, mice and rats are often used to study diseases such as diabetes, heart disease, and cancer because they have similar metabolic and cardiovascular systems to humans.
2) They can be genetically manipulated: Animal disease models can be genetically engineered to develop specific diseases or to model human genetic disorders. This allows researchers to study the progression of the disease and test potential treatments in a controlled environment.
3) They can be used to test drugs and therapies: Before new drugs or therapies are tested in humans, they are often first tested in animal models of disease. This allows researchers to assess the safety and efficacy of the treatment before moving on to human clinical trials.
4) They can provide insights into disease mechanisms: Studying disease models in animals can provide valuable insights into the underlying mechanisms of a particular disease. This information can then be used to develop new treatments or improve existing ones.
5) Reduces the need for human testing: Using animal disease models reduces the need for human testing, which can be time-consuming, expensive, and ethically challenging. However, it is important to note that animal models are not perfect substitutes for human subjects, and results obtained from animal studies may not always translate to humans.
6) They can be used to study infectious diseases: Animal disease models can be used to study infectious diseases such as HIV, TB, and malaria. These models allow researchers to understand how the disease is transmitted, how it progresses, and how it responds to treatment.
7) They can be used to study complex diseases: Animal disease models can be used to study complex diseases such as cancer, diabetes, and heart disease. These models allow researchers to understand the underlying mechanisms of the disease and test potential treatments.
8) They are cost-effective: Animal disease models are often less expensive than human clinical trials, making them a cost-effective way to conduct research.
9) They can be used to study drug delivery: Animal disease models can be used to study drug delivery and pharmacokinetics, which is important for developing new drugs and drug delivery systems.
10) They can be used to study aging: Animal disease models can be used to study the aging process and age-related diseases such as Alzheimer's and Parkinson's. This allows researchers to understand how aging contributes to disease and develop potential treatments.
Body weight is an important health indicator, as it can affect an individual's risk for certain medical conditions, such as obesity, diabetes, and cardiovascular disease. Maintaining a healthy body weight is essential for overall health and well-being, and there are many ways to do so, including a balanced diet, regular exercise, and other lifestyle changes.
There are several ways to measure body weight, including:
1. Scale: This is the most common method of measuring body weight, and it involves standing on a scale that displays the individual's weight in kg or lb.
2. Body fat calipers: These are used to measure body fat percentage by pinching the skin at specific points on the body.
3. Skinfold measurements: This method involves measuring the thickness of the skin folds at specific points on the body to estimate body fat percentage.
4. Bioelectrical impedance analysis (BIA): This is a non-invasive method that uses electrical impulses to measure body fat percentage.
5. Dual-energy X-ray absorptiometry (DXA): This is a more accurate method of measuring body composition, including bone density and body fat percentage.
It's important to note that body weight can fluctuate throughout the day due to factors such as water retention, so it's best to measure body weight at the same time each day for the most accurate results. Additionally, it's important to use a reliable scale or measuring tool to ensure accurate measurements.
Types of Experimental Diabetes Mellitus include:
1. Streptozotocin-induced diabetes: This type of EDM is caused by administration of streptozotocin, a chemical that damages the insulin-producing beta cells in the pancreas, leading to high blood sugar levels.
2. Alloxan-induced diabetes: This type of EDM is caused by administration of alloxan, a chemical that also damages the insulin-producing beta cells in the pancreas.
3. Pancreatectomy-induced diabetes: In this type of EDM, the pancreas is surgically removed or damaged, leading to loss of insulin production and high blood sugar levels.
Experimental Diabetes Mellitus has several applications in research, including:
1. Testing new drugs and therapies for diabetes treatment: EDM allows researchers to evaluate the effectiveness of new treatments on blood sugar control and other physiological processes.
2. Studying the pathophysiology of diabetes: By inducing EDM in animals, researchers can study the progression of diabetes and its effects on various organs and tissues.
3. Investigating the role of genetics in diabetes: Researchers can use EDM to study the effects of genetic mutations on diabetes development and progression.
4. Evaluating the efficacy of new diagnostic techniques: EDM allows researchers to test new methods for diagnosing diabetes and monitoring blood sugar levels.
5. Investigating the complications of diabetes: By inducing EDM in animals, researchers can study the development of complications such as retinopathy, nephropathy, and cardiovascular disease.
In conclusion, Experimental Diabetes Mellitus is a valuable tool for researchers studying diabetes and its complications. The technique allows for precise control over blood sugar levels and has numerous applications in testing new treatments, studying the pathophysiology of diabetes, investigating the role of genetics, evaluating new diagnostic techniques, and investigating complications.
There are two types of hypertension:
1. Primary Hypertension: This type of hypertension has no identifiable cause and is also known as essential hypertension. It accounts for about 90% of all cases of hypertension.
2. Secondary Hypertension: This type of hypertension is caused by an underlying medical condition or medication. It accounts for about 10% of all cases of hypertension.
Some common causes of secondary hypertension include:
* Kidney disease
* Adrenal gland disorders
* Hormonal imbalances
* Certain medications
* Sleep apnea
* Cocaine use
There are also several risk factors for hypertension, including:
* Age (the risk increases with age)
* Family history of hypertension
* Obesity
* Lack of exercise
* High sodium intake
* Low potassium intake
* Stress
Hypertension is often asymptomatic, and it can cause damage to the blood vessels and organs over time. Some potential complications of hypertension include:
* Heart disease (e.g., heart attacks, heart failure)
* Stroke
* Kidney disease (e.g., chronic kidney disease, end-stage renal disease)
* Vision loss (e.g., retinopathy)
* Peripheral artery disease
Hypertension is typically diagnosed through blood pressure readings taken over a period of time. Treatment for hypertension may include lifestyle changes (e.g., diet, exercise, stress management), medications, or a combination of both. The goal of treatment is to reduce the risk of complications and improve quality of life.
Reperfusion injury can cause inflammation, cell death, and impaired function in the affected tissue or organ. The severity of reperfusion injury can vary depending on the duration and severity of the initial ischemic event, as well as the promptness and effectiveness of treatment to restore blood flow.
Reperfusion injury can be a complicating factor in various medical conditions, including:
1. Myocardial infarction (heart attack): Reperfusion injury can occur when blood flow is restored to the heart muscle after a heart attack, leading to inflammation and cell death.
2. Stroke: Reperfusion injury can occur when blood flow is restored to the brain after an ischemic stroke, leading to inflammation and damage to brain tissue.
3. Organ transplantation: Reperfusion injury can occur when a transplanted organ is subjected to ischemia during harvesting or preservation, and then reperfused with blood.
4. Peripheral arterial disease: Reperfusion injury can occur when blood flow is restored to a previously occluded peripheral artery, leading to inflammation and damage to the affected tissue.
Treatment of reperfusion injury often involves medications to reduce inflammation and oxidative stress, as well as supportive care to manage symptoms and prevent further complications. In some cases, experimental therapies such as stem cell transplantation or gene therapy may be used to promote tissue repair and regeneration.
People with reflex epilepsy may experience a range of symptoms, including:
1. Seizures triggered by specific stimuli such as flashing lights, loud noises, or certain patterns or colors.
2. Loss of consciousness or awareness during the seizure.
3. Body stiffness or rigidity.
4. Jerky movements or twitches.
5. Altered sensation or perception.
6. Vision problems or blurred vision.
7. Hearing problems or ringing in the ears.
8. Nausea and vomiting.
9. Headaches.
10. Fatigue and exhaustion after the seizure.
Reflex epilepsy can be difficult to diagnose, as the seizures may not always be obvious or easy to identify. In some cases, people with reflex epilepsy may experience seizures that are triggered by internal stimuli, such as changes in hormone levels or stress, rather than external stimuli.
Treatment for reflex epilepsy typically involves avoiding triggers and managing stress, as well as medication to control seizures. In some cases, surgery may be recommended to remove the area of the brain that is causing the seizures. It's important for people with reflex epilepsy to work closely with their healthcare provider to develop a treatment plan that is tailored to their specific needs and circumstances.
1. Hantavirus pulmonary syndrome (HPS): This is a severe respiratory disease caused by the hantavirus, which is found in the urine and saliva of infected rodents. Symptoms of HPS can include fever, headache, muscle pain, and difficulty breathing.
2. Leptospirosis: This is a bacterial infection caused by the bacterium Leptospira, which is found in the urine of infected rodents. Symptoms can include fever, headache, muscle pain, and jaundice (yellowing of the skin and eyes).
3. Rat-bite fever: This is a bacterial infection caused by the bacterium Streptobacillus moniliformis, which is found in the saliva of infected rodents. Symptoms can include fever, headache, muscle pain, and swollen lymph nodes.
4. Lymphocytic choriomeningitis (LCM): This is a viral infection caused by the lymphocytic choriomeningitis virus (LCMV), which is found in the urine and saliva of infected rodents. Symptoms can include fever, headache, muscle pain, and meningitis (inflammation of the membranes surrounding the brain and spinal cord).
5. Tularemia: This is a bacterial infection caused by the bacterium Francisella tularensis, which is found in the urine and saliva of infected rodents. Symptoms can include fever, headache, muscle pain, and swollen lymph nodes.
These are just a few examples of the many diseases that can be transmitted to humans through contact with rodents. It is important to take precautions when handling or removing rodents, as they can pose a serious health risk. If you suspect that you have been exposed to a rodent-borne disease, it is important to seek medical attention as soon as possible.
Without more information about the context in which this term is being used, it is difficult to provide a clear definition or interpretation of its meaning. However, based on the name "Walker" and the fact that it is followed by a number (256), it is possible that this term may refer to a specific type of cancer or tumor that has been identified in a patient with the last name Walker.
It's important to note that the diagnosis and treatment of cancer can be complex and highly individualized, and any medical information or terminology should only be interpreted and applied by qualified healthcare professionals who have access to the relevant clinical context and patient information.
Examples of how 'Tissue Adhesions' is used in the medical field:
1. In gastrointestinal surgery, tissue adhesions can form between the intestines and other organs, leading to bowel obstruction, inflammation, or other complications.
2. In cardiovascular surgery, tissue adhesions can form between the heart and surrounding tissues, causing impaired heart function and increasing the risk of postoperative complications.
3. In gynecological surgery, tissue adhesions can form between the uterus and other pelvic organs, leading to pain, bleeding, and infertility.
4. In oncologic surgery, tissue adhesions can form between cancerous tissues and surrounding normal tissues, making it difficult to remove the tumor completely.
5. In chronic diseases such as endometriosis, tissue adhesions can form between the uterus and other pelvic structures, leading to pain and infertility.
6. Tissue adhesions can also form within the skin, causing keloids or other types of scarring.
Treatment options for tissue adhesions depend on the location, size, and severity of the adhesions, as well as the underlying cause. Some common treatment options include:
1. Surgical removal of adhesions: This involves surgically removing the fibrous bands or scar tissue that are causing the adhesions.
2. Steroid injections: Injecting steroids into the affected area can help reduce inflammation and shrink the adhesions.
3. Physical therapy: Gentle stretching and exercise can help improve range of motion and reduce stiffness in the affected area.
4. Radiofrequency ablation: This is a minimally invasive procedure that uses heat to break down and remove the fibrous bands causing the adhesions.
5. Laser therapy: Laser therapy can be used to break down and remove the fibrous bands causing the adhesions, or to reduce inflammation and promote healing.
6. Natural remedies: Some natural remedies such as turmeric, ginger, and omega-3 fatty acids have anti-inflammatory properties and may help reduce inflammation and improve symptoms.
Preventing tissue adhesions is not always possible, but there are some measures that can be taken to reduce the risk of their formation. These include:
1. Proper wound care: Keeping wounds clean and dry, and using sterile dressings can help prevent infection and reduce the risk of adhesion formation.
2. Minimizing trauma: Avoiding unnecessary trauma to the affected area can help reduce the risk of adhesion formation.
3. Gentle exercise: Gentle exercise and stretching after surgery or injury can help improve range of motion and reduce stiffness in the affected area.
4. Early mobilization: Early mobilization after surgery or injury can help reduce the risk of adhesion formation.
5. Avoiding smoking: Smoking can impede wound healing and increase the risk of adhesion formation, so avoiding smoking is recommended.
6. Using anti-adhesive agents: Applying anti-adhesive agents such as silicone or hydrogel to the affected area after surgery or injury can help reduce the risk of adhesion formation.
It's important to note that the most effective method for preventing or treating tissue adhesions will depend on the specific cause and location of the adhesions, as well as the individual patient's needs and medical history. A healthcare professional should be consulted for proper evaluation and treatment.
Cedrus deodara
Hepatotoxicity
Anthonotha macrophylla
Timeline of tuberous sclerosis
Helen Dean King
Bean
Endosulfan
Katarína Horáková
Episodic memory
Wireless device radiation and health
2-Ethylhexanol
Heneicosane
Pulmonary alveolar proteinosis
Ecbolium viride
Sterculia setigera
Harderian gland
Spontaneously hypertensive rat
Glycerol-1-phosphatase
Gymnema sylvestre
Rotula aquatica
Epididymis evolution from reptiles to mammals
Andrej Janež
Ipomoea aquatica
Surinabant
Tityustoxin
Chelidonium majus
Dichloroacetylene
Tabebuia rosea
Lapachol
Lapacho
Sterigmatocystin
Cultured neuronal network
Animal psychopathology
Laboratory rat
Physiological effects in space
Phenylpiracetam
Kosmos 2044
Meso-Zeaxanthin
Kosmos 1514
Tellurium dioxide
Methoxymethylfurfural
Arylcyclohexylamine
Zinc transporter ZIP12
Polio vaccine
Libidibia ferrea
Prosopis cineraria
Hilary Koprowski
Joseph Olurotimi Sanya
Carpaine
Henry Herbert Donaldson
Phosphoenolpyruvate carboxykinase
Ellen Heber-Katz
Clerodendrum glandulosum
Perlecan
Dimethocaine
Thrombus Degradation by Fibrinolytic Enzyme of Stenotrophomonas sp. Originated from Indonesian Soybean-Based Fermented Food on...
Wistar Rats. | Pharmacognosy Research
Ethanol Increases Glutamate Neurotransmission in the Posterior Ventral Tegmental Area of Female Wistar Rats<...
Wistar rats under water and food restriction
Periodontal disease induced by Porphyromonasgingivalis and Fusobacterium nucleatum in Wistar rats
Previous short-term use of testosterone propionate enhances muscle hypertrophy in Wistar rats submitted to ladder-based...
View of Screening of antidepressant activity of marsilea minuta in wistar albino rats
View of Attenuation of Paraquat-Induced Nephrotoxicity and Dysfunction in Male Wistar Albino Rats
Aqueous extract of Cola anomala nuts protects against metabolic disorders in albino Wistar rats - CAMJOURNALS
Rattus norvegicus - Wikimedia Commons
Effects of chronic stress and high-fat diet on metabolic and nutritional parameters in Wistar rats
Vitamin C modulates adrenaline-augmented gastric injury via cardiac troponin/creatine kinase pathway in Wistar rats
HISTOLOGICAL VARIANCES OF MORINGA OLIFERA ON THE KIDNEY OF ADULT WISTAR RATS | Innovare Journal of Medical Sciences
ArboCat Virus: Seoul (SEOV)
Schwann cell processes guide regeneration of peripheral axons
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Some studies on Campylobacter jejuni in Sprague Dawley and Wistar female rats /
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Protective effect of blackthorn fruits (Prunus spinosa) against tartrazine toxicity development in albino Wistar rats | BMC...
Nutrients | Free Full-Text | The Potential Benefits of Red Beetroot Supplementation in Health and Disease
Anti-diabetic Activity of Chrysophyllum albidum (G. Don) Stem Bark in Alloxan-induced Type 1 Diabetic Female Wistar Rats |...
Wound Healing Activity of Ethanolic Extract Gel of Tawas Ut Tuber (Ampelocissus rubiginosa L.) in Incisional Model Wistar Rats ...
Comparison between Oral Administration of Kaempferia galanga Rhizome Extract and Simvastatin in Improving Lipid Profile of...
Afferent Neuropeptide Y projections to the ventral tegmental area in normal-weight male Wistar rats - Netherlands Institute for...
Antidepressants modulate behavioral, biochemical, and histological alterations induced by chronic aluminum chloride...
View of Antihyperlipidemic Property of a Dietary Supplement of Moringa Oleifera Leaves and Pleurotus Ostreatus in Wistar Rats...
IMSEAR at SEARO: In vivo Antisalmonellal and Antioxidant Activity of Hydroethanolic Extract of Bauhinia rufescens Leaves in...
Biomonitoring Summary | CDC
Registration Dossier - ECHA
Registration Dossier - ECHA
Sprague-Dawley2
Ratos Wistar2
- MATERIAIS E MÉTODOS: Ratos Wistar machos (30 dias de idade/70-100 g) foram distribuídos em quatro grupos: dieta-normal (NC), estresse crônico (St), dieta rica em gordura (HD) e estresse crônico/dieta rica em gordura (HD/St). O estresse consistiu em imobilização durante 15 semanas, 5 vezes por semana 1h por dia e a dieta rica em gordura foi oferecida por 15 semanas. (unesp.br)
- Inicialmente foi realizado um ensaio biológico com ratos Wistar. (usp.br)
Strain1
- A strain of albino rat developed at the Wistar Institute that has spread widely at other institutions. (bvsalud.org)
Parameters2
- This study investigated the effect of vitamin C on some gastric parameters in myocardial injury in rats. (ac.ir)
- Effects of aqueous extract of Mangifera indica L. (Mango) Stem bark on haematological parameters of normal albino rats. (innovareacademics.in)
Orally3
- For in vivo studies, 25 Wistar rats were used: normal control, negative control, treatment groups with crude and semipurified enzyme given orally at 25 mg/kg, and positive control group which received Lumbrokinase at 25 mg/kg. (hindawi.com)
- The present research aims to examine a periodontal disease model in which specific pathogen-free Wistar rats are orally exposed to Porphyromonas gingivalis associated with Fusobacterium nucleatum . (bvsalud.org)
- 2004).In rats, orally administered 4- tert -octylphenol was well absorbed, did not bioaccumulate, and was quickly eliminated from the blood (Certa et al. (cdc.gov)
Twenty2
- Twenty adult male Wistar rats were divided into two groups. (bvsalud.org)
- Twenty-eight rats were divided equally into groups initial control (CI), 4-week TP (CT4), 4-week TP + LRT (TRT), and placebo + LRT (RT). (bvsalud.org)
0.052
- 0.05) to the control group after MO administration, the organ (Kidneys) shows a significant difference between the kidneys (left and right kidneys) in relation to the control group rats. (innovareacademics.in)
- 0.05) lowered in rats who received AlCl 3 along with either rivastigmine or escitalopram. (manipal.edu)
Experimentally2
- Objective: This work aims to evaluate the in vivo antisalmonellal and antioxidant activity of the 95% hydroethanolic extract of the leaves of Bauhinia rufescens (Fabaceae) in rats experimentally infected with Salmonella Typhi ATCC6539, as an alternative therapy. (who.int)
- To further investigate the potential susceptibility of rats to infection with human HEV, we experimentally injected nude rats with G3 HEV and monitored virus growth. (cdc.gov)
Methods4
- Methods: Adult female Wistar rats were implanted with microdialysis probes in the pVTA. (elsevier.com)
- Methods: An experimental study with a randomized pretest-posttest control group design was conducted on 14 male Wistar rats, aged 2-2.5 months which suffered from dyslipidemia. (researchbib.com)
- Materials and Methods: Thirty rats were used. (manipal.edu)
- Methods: The rats were randomly divided into twelve groups (six per sex) of animals. (who.int)
Adult male1
- Chronic administration of the environmental pollutant 4- tert -octylphenol to adult male rats interferes with the secretion of luteinizing hormone,follicle-stimulating hormone, prolactin, and testosterone. (cdc.gov)
Thoracic2
- All rats on the study were subject to a gross pathological examination consisting of an external examination and opening of abdominal and thoracic cavities. (europa.eu)
- and injection of Wistar-rats in the thoracic cavity with asbestos samples to study the carcinogenesis of asbestos fibers as related to surface chemistry. (cdc.gov)
Metabolic2
Toxicity3
- Rats were observed for toxicity and mortality at 0.5, 1, 2, 3, 4, and 6 hours post dosing, and then twice daily for the remainder of the 14 day observation period. (europa.eu)
- An acute oral toxicity study (Up-and-Down Procedure) was conducted using five female Wistar rats given a single oral dose of the test material (Undiluted, as received). (europa.eu)
- Combined Repeated Dose Toxicity Study with the Reproduction/Developmental Toxicity Screening Test in Wistar Rats with (Confidential). (epa.gov)
Male4
- This study aimed to determine the effect of Kaempferia galanga rhizome extract on improving the lipid profile of male Wistar rats with dyslipidemia. (researchbib.com)
- We determined, in normal-weight male Wistar rats, if the source of VTA NPY is local, and/or whether it is derived from VTA-projecting neurons. (nin.nl)
- Thus, VTA NPY originates from the hypothalamic Arc and the ventrolateral medulla of the brainstem in normal-weight male Wistar rats. (nin.nl)
- Bian Q, Qian J, Xu L, Chen J, Song L, Wang X. The toxic effects of 4- tert -octylphenol on the reproductive system of male rats. (cdc.gov)
Rattus1
- For example, anti-HEV IgG has been detected in various rat species, including Norway ( Rattus norvegicus ), black ( Rattus rattus ), and cotton ( Sigmodon hispidus ) rats, by using ELISA with antigens derived from G1 HEV. (cdc.gov)
Subjects1
- Subjects were 29 Wistar rats bred at the Experimental Psychology Department Animal House. (bvsalud.org)
Acute2
- During microdialysis, rats received acute intraperitoneal (i.p.) injection of saline or EtOH (0.5, 1.0, or 2.0g/kg), and extracellular glutamate levels were measured in the pVTA. (elsevier.com)
- The highest level at which no acute airway irritation as based on both breathing pattern and frequency was observed in both rat strains was 14 mg/m3. (cdc.gov)
Antibodies1
- All rats were negative for G3 HEV RNA and anti-HEV antibodies, as determined by nested reverse transcription PCR ( 10 ) and ELISA ( 8 ), respectively. (cdc.gov)
Groups3
- The rats from the CT4 and TRT groups were treated with TP for four weeks (10 mg/kg/week). (bvsalud.org)
- Thirty Wistar rats were divided into five groups (n = 6). (ac.ir)
- The 6 rats were randomly assigned to 2 groups, injected intravenously with 500 µL of an HEV sample suspension through the tail vein, and monitored for 3 months. (cdc.gov)
Study6
- The aim of the present study was to investigate systematically the body weight development of rats submitted to controlled water or food restriction for about 7 months, as compared to animals under an ad Lib regimen. (bvsalud.org)
- Prior studies have shown that it is necessary to place ligatures around molars to study periodontal destruction in rats. (bvsalud.org)
- Our study showed that four weeks following infection with Porphyromonas gingivalis and Fusobacterium nucleatum bone loss in Wistar rats could be identified. (bvsalud.org)
- At study termination, all rats were humanely euthanised by carbon dioxide asphyxiation. (europa.eu)
- Comparative metabolism study of ß-lapachone in mouse, rat, dog, monkey, and human liver microsomes using liquid chromatography-tandem mass spectrometry. (medlineplus.gov)
- recently reported that G1, G2, and G3 do not infect laboratory rats ( 7 ), and we found in a previous study that laboratory rats are not susceptible to G1, G3, or G4 HEV ( 8 ). (cdc.gov)
Increases1
- In BN rats, changes in breathing pat- tern were seen at levels of 29 mg/m3 and higher and decreases in frequency at 60 mg/m3 and higher, whereas in Wistar rats changes in both pattern and frequency (increases fol- lowed by decreases) were seen at levels of 34 mg/m3 and higher. (cdc.gov)
Laboratory1
- also reported that human HEV (presumably G1) was transmissible to Wistar laboratory rats ( 6 ). (cdc.gov)
Leaves2
- View of Antihyperlipidemic Property of a Dietary Supplement of Moringa Oleifera Leaves and Pleurotus Ostreatus in Wistar Rats Stressed by Combination of Ethanol-Paracetamol. (medicalresearchjournal.org)
- Djenguemtar J, Goka M. S. C, Noubom M, Konack E. Y, Kamsu G. T, Sokoudjou J. B, Feudjio H. B. L, Kodjio N, Gatsing D.. In vivo Antisalmonellal and Antioxidant Activity of Hydroethanolic Extract of Bauhinia rufescens Leaves in Wistar Albino Rats Infected with Salmonella Typhi. (who.int)
Extract1
- Histological sections shows a normal Glomerulli, Peri-Glomerular Space, Convoluted Tubules, and Interstitium, after administration of the Crude Aqueous Extract of MO lame in terms with the control group rats. (innovareacademics.in)
Investigate1
- To investigate the effects of the previous administration of testosterone propionate (TP) on the morphology of the gastrocnemius muscle of Wistar rats submitted to ladder-based resistance training (LRT). (bvsalud.org)
Fermented food1
- of Indonesian fermented food was capable of degrading thrombus induced in Wistar rats. (hindawi.com)
Infections2
Body weight2
Administration1
- In conclusion, short-term TP administration before resistance training can elicit a greater N/f ratio and size of the mean fCSA of the Gastrocnemius muscle of young adult Wistar rats than resistance training alone. (bvsalud.org)
Studies1
- All the studies reported here were performed on rats (Wistar, female). (cdc.gov)
Pattern2
- The data illustrate the general pattern of body mass acquisition in rats, in the presence and absence of water or food restriction, along a period corresponding to a typical behavioral experiment. (bvsalud.org)
- ABSTRACT Objective: To analyze wound contraction and histomorphometric pattern of lesions in Wistar rats undergoing doxorubicin extravasation. (bvsalud.org)
Wild1
- this finding suggests that wild rats are hosts for G3 HEV. (cdc.gov)
Group1
- the 3 rats in group 2 were injected with the cell culture supernatant sample, which contained 4 × 10 6 copies of G3 HEV. (cdc.gov)
Original1
- Esto ha diluido en gran medida la cepa original. (bvsalud.org)
Cell1
- Safety of the bacterial enzyme from the Indonesian fermented Oncom was tested using cell culture and experimental rats, while the effect of Stenotrophomonas enzyme on degrading thrombus was observed using the experimental rats. (hindawi.com)
Human3
- Although rats have long been suspected to be a potential reservoir for human HEV, no direct evidence has been found. (cdc.gov)
- The susceptibility of rats to human HEV genotypes is controversial. (cdc.gov)
- Abstract Objective: to evaluate the effect of photobiomodulation with low-level 660 nm laser alone or associated with Human Amniotic Membrane in the repair of partial-thickness burns in rats. (bvsalud.org)
Found1
- Clinically severe and moderate hospitalized cases in Seoul City where only urban rats were found. (cdc.gov)
Effect2
- Objective: To assess the effect of duloxetine and escitalopram on aluminum chloride (AlCl3)-induced memory impairment in rats. (manipal.edu)
- Conclusion: Escitalopram and duloxetine exerted a protective effect against AlCl 3 -induced memory impairment in rats. (manipal.edu)