A strain of albino rat developed at the Wistar Institute that has spread widely at other institutions. This has markedly diluted the original strain.
A strain of Rattus norvegicus used as a normotensive control for the spontaneous hypertensive rats (SHR).
Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.
A strain of Rattus norvegicus with elevated blood pressure used as a model for studying hypertension and stroke.
Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations or by parent x offspring matings carried out with certain restrictions. This also includes animals with a long history of closed colony breeding.
The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.
A process involving chance used in therapeutic trials or other research endeavor for allocating experimental subjects, human or animal, between treatment and control groups, or among treatment groups. It may also apply to experiments on inanimate objects.
Concentrated pharmaceutical preparations of plants obtained by removing active constituents with a suitable solvent, which is evaporated away, and adjusting the residue to a prescribed standard.
The measurement of an organ in volume, mass, or heaviness.
A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.
Elements of limited time intervals, contributing to particular results or situations.
The relationship between the dose of an administered drug and the response of the organism to the drug.
Rats bearing mutant genes which are phenotypically expressed in the animals.
Mutant strain of Rattus norvegicus which is used as a disease model of kernicterus.
PRESSURE of the BLOOD on the ARTERIES and other BLOOD VESSELS.
Body organ that filters blood for the secretion of URINE and that regulates ion concentrations.
Diabetes mellitus induced experimentally by administration of various diabetogenic agents or by PANCREATECTOMY.
Diet modification and physical exercise to improve the ability of animals to perform physical activities.
The restriction of a characteristic behavior, anatomical structure or physical system, such as immune response; metabolic response, or gene or gene variant to the members of one species. It refers to that property which differentiates one species from another but it is also used for phylogenetic levels higher or lower than the species.
Non-human animals, selected because of specific characteristics, for use in experimental research, teaching, or testing.
A clear, colorless liquid rapidly absorbed from the gastrointestinal tract and distributed throughout the body. It has bactericidal activity and is used often as a topical disinfectant. It is widely used as a solvent and preservative in pharmaceutical preparations as well as serving as the primary ingredient in ALCOHOLIC BEVERAGES.
Peroxidase catalyzed oxidation of lipids using hydrogen peroxide as an electron acceptor.
Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.
The dialdehyde of malonic acid.
A statistical technique that isolates and assesses the contributions of categorical independent variables to variation in the mean of a continuous dependent variable.
Naturally occurring or synthetic substances that inhibit or retard the oxidation of a substance to which it is added. They counteract the harmful and damaging effects of oxidation in animal tissues.
Use of plants or herbs to treat diseases or to alleviate pain.
A strain of Rattus norvegicus which is a model for spontaneous insulin-dependent diabetes mellitus (DIABETES MELLITUS, INSULIN-DEPENDENT).
A disturbance in the prooxidant-antioxidant balance in favor of the former, leading to potential damage. Indicators of oxidative stress include damaged DNA bases, protein oxidation products, and lipid peroxidation products (Sies, Oxidative Stress, 1991, pxv-xvi).
Forceful administration into the peritoneal cavity of liquid medication, nutrient, or other fluid through a hollow needle piercing the abdominal wall.
The observable response an animal makes to any situation.
Low-molecular-weight end products, probably malondialdehyde, that are formed during the decomposition of lipid peroxidation products. These compounds react with thiobarbituric acid to form a fluorescent red adduct.
Adverse functional, metabolic, or structural changes in ischemic tissues resulting from the restoration of blood flow to the tissue (REPERFUSION), including swelling; HEMORRHAGE; NECROSIS; and damage from FREE RADICALS. The most common instance is MYOCARDIAL REPERFUSION INJURY.
The consumption of liquids.
A nitrosoguanidine derivative with potent mutagenic and carcinogenic properties.
The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
Histochemical localization of immunoreactive substances using labeled antibodies as reagents.
A subtype of epilepsy characterized by seizures that are consistently provoked by a certain specific stimulus. Auditory, visual, and somatosensory stimuli as well as the acts of writing, reading, eating, and decision making are examples of events or activities that may induce seizure activity in affected individuals. (From Neurol Clin 1994 Feb;12(1):57-8)
The consumption of edible substances.
Glucose in blood.
An antibiotic that is produced by Stretomyces achromogenes. It is used as an antineoplastic agent and to induce diabetes in experimental animals.
A free radical gas produced endogenously by a variety of mammalian cells, synthesized from ARGININE by NITRIC OXIDE SYNTHASE. Nitric oxide is one of the ENDOTHELIUM-DEPENDENT RELAXING FACTORS released by the vascular endothelium and mediates VASODILATION. It also inhibits platelet aggregation, induces disaggregation of aggregated platelets, and inhibits platelet adhesion to the vascular endothelium. Nitric oxide activates cytosolic GUANYLATE CYCLASE and thus elevates intracellular levels of CYCLIC GMP.
The number of times the HEART VENTRICLES contract per unit of time, usually per minute.
A metabolite of TESTOSTERONE or ANDROSTENEDIONE with a 3-alpha-hydroxyl group and without the double bond. The 3-beta hydroxyl isomer is epiandrosterone.
An adrenocortical steroid that has modest but significant activities as a mineralocorticoid and a glucocorticoid. (From Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed, p1437)
An oxidoreductase that catalyzes the conversion of HYDROGEN PEROXIDE to water and oxygen. It is present in many animal cells. A deficiency of this enzyme results in ACATALASIA.
The muscle tissue of the HEART. It is composed of striated, involuntary muscle cells (MYOCYTES, CARDIAC) connected to form the contractile pump to generate blood flow.
Diseases of rodents of the order RODENTIA. This term includes diseases of Sciuridae (squirrels), Geomyidae (gophers), Heteromyidae (pouched mice), Castoridae (beavers), Cricetidae (rats and mice), Muridae (Old World rats and mice), Erethizontidae (porcupines), and Caviidae (guinea pigs).
The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM.
A 51-amino acid pancreatic hormone that plays a major role in the regulation of glucose metabolism, directly by suppressing endogenous glucose production (GLYCOGENOLYSIS; GLUCONEOGENESIS) and indirectly by suppressing GLUCAGON secretion and LIPOLYSIS. Native insulin is a globular protein comprised of a zinc-coordinated hexamer. Each insulin monomer containing two chains, A (21 residues) and B (30 residues), linked by two disulfide bonds. Insulin is used as a drug to control insulin-dependent diabetes mellitus (DIABETES MELLITUS, TYPE 1).
An oxidoreductase that catalyzes the reaction between superoxide anions and hydrogen to yield molecular oxygen and hydrogen peroxide. The enzyme protects the cell against dangerous levels of superoxide. EC 1.15.1.1.
Refers to animals in the period of time just after birth.
Enzymes of the transferase class that catalyze the conversion of L-aspartate and 2-ketoglutarate to oxaloacetate and L-glutamate. EC 2.6.1.1.
A transplantable carcinoma of the rat that originally appeared spontaneously in the mammary gland of a pregnant albino rat, and which now resembles a carcinoma in young transplants and a sarcoma in older transplants. (Stedman, 25th ed)
A non-selective inhibitor of nitric oxide synthase. It has been used experimentally to induce hypertension.
A subtype of striated muscle, attached by TENDONS to the SKELETON. Skeletal muscles are innervated and their movement can be consciously controlled. They are also called voluntary muscles.
Pathological processes consisting of the union of the opposing surfaces of a wound.
A colorless, odorless, viscous dihydroxy alcohol. It has a sweet taste, but is poisonous if ingested. Ethylene glycol is the most important glycol commercially available and is manufactured on a large scale in the United States. It is used as an antifreeze and coolant, in hydraulic fluids, and in the manufacture of low-freezing dynamites and resins.
An NADPH-dependent enzyme that catalyzes the conversion of L-ARGININE and OXYGEN to produce CITRULLINE and NITRIC OXIDE.
A response to a cue that is instrumental in avoiding a noxious experience.
A very loosely defined group of drugs that tend to reduce the activity of the central nervous system. The major groups included here are ethyl alcohol, anesthetics, hypnotics and sedatives, narcotics, and tranquilizing agents (antipsychotics and antianxiety agents).
The giving of drugs, chemicals, or other substances by mouth.
The surgical removal of one or both ovaries.
Regular course of eating and drinking adopted by a person or animal.
Application of a ligature to tie a vessel or strangulate a part.
Synthetic or natural substances which are given to prevent a disease or disorder or are used in the process of treating a disease or injury due to a poisonous agent.
An enzyme that catalyzes the conversion of L-alanine and 2-oxoglutarate to pyruvate and L-glutamate. (From Enzyme Nomenclature, 1992) EC 2.6.1.2.
The physical activity of a human or an animal as a behavioral phenomenon.
A family of enzymes accepting a wide range of substrates, including phenols, alcohols, amines, and fatty acids. They function as drug-metabolizing enzymes that catalyze the conjugation of UDPglucuronic acid to a variety of endogenous and exogenous compounds. EC 2.4.1.17.
An enzyme catalyzing the oxidation of 2 moles of glutathione in the presence of hydrogen peroxide to yield oxidized glutathione and water. EC 1.11.1.9.
An activity in which the body is propelled through water by specific movement of the arms and/or the legs. Swimming as propulsion through water by the movement of limbs, tail, or fins of animals is often studied as a form of PHYSICAL EXERTION or endurance.
The spurge family of flowering plants, in the order Euphorbiales, contains some 7,500 species in 275 genera. The family consists of annual and perennial herbs and woody shrubs or trees.
Injections into the cerebral ventricles.
Arteries which arise from the abdominal aorta and distribute to most of the intestines.
A tripeptide with many roles in cells. It conjugates to drugs to make them more soluble for excretion, is a cofactor for some enzymes, is involved in protein disulfide bond rearrangement and reduces peroxides.
Restoration of integrity to traumatized tissue.
Precursor of epinephrine that is secreted by the adrenal medulla and is a widespread central and autonomic neurotransmitter. Norepinephrine is the principal transmitter of most postganglionic sympathetic fibers and of the diffuse projection system in the brain arising from the locus ceruleus. It is also found in plants and is used pharmacologically as a sympathomimetic.
A diet that contains limited amounts of protein. It is prescribed in some cases to slow the progression of renal failure. (From Segen, Dictionary of Modern Medicine, 1992)
The tendency to explore or investigate a novel environment. It is considered a motivation not clearly distinguishable from curiosity.
Fats present in food, especially in animal products such as meat, meat products, butter, ghee. They are present in lower amounts in nuts, seeds, and avocados.
Preclinical testing of drugs in experimental animals or in vitro for their biological and toxic effects and potential clinical applications.
L-Tryptophyl-L-methionyl-L-aspartyl-L-phenylalaninamide. The C-terminal tetrapeptide of gastrin. It is the smallest peptide fragment of gastrin which has the same physiological and pharmacological activity as gastrin.
Orthodontic techniques used to correct the malposition of a single tooth.
Substances that increase the risk of NEOPLASMS in humans or animals. Both genotoxic chemicals, which affect DNA directly, and nongenotoxic chemicals, which induce neoplasms by other mechanism, are included.
Use of a device for the purpose of controlling movement of all or part of the body. Splinting and casting are FRACTURE FIXATION.

Sex differences in the effects of early neocortical injury on neuronal size distribution of the medial geniculate nucleus in the rat are mediated by perinatal gonadal steroids. (1/41636)

Freezing injury to the cortical plate of rats induces cerebrocortical microgyria and, in males but not females, a shift toward greater numbers of small neurons in the medial geniculate nucleus (MGN). The purpose of the current study was to examine a hormonal basis for this sex difference. Cross-sectional neuronal areas of the MGN were measured in male rats, untreated female rats and female rats treated perinatally with testosterone propionate, all of which had received either neonatal cortical freezing or sham injury. Both male and androgenized female rats with microgyria had significantly smaller MGN neurons when compared to their sham-operated counterparts, whereas untreated females with microgyria did not. These differences were also reflected in MGN neuronal size distribution: both male and androgenized female rats with microgyria had more small and fewer large neurons in their MGN in comparison to shams, while there was no difference in MGN neuronal size distribution between lesioned and sham females. These findings suggest that perinatal gonadal steroids mediate the sex difference in thalamic response to induction of microgyria in the rat cortex.  (+info)

Activation of alveolar macrophages in lung injury associated with experimental acute pancreatitis is mediated by the liver. (2/41636)

OBJECTIVE: To evaluate (1) whether alveolar macrophages are activated as a consequence of acute pancreatitis (AP), (2) the implication of inflammatory factors released by these macrophages in the process of neutrophil migration into the lungs observed in lung injury induced by AP, and (3) the role of the liver in the activation of alveolar macrophages. SUMMARY BACKGROUND DATA: Acute lung injury is the extrapancreatic complication most frequently associated with death and complications in severe AP. Neutrophil infiltration into the lungs seems to be related to the release of systemic and local mediators. The liver and alveolar macrophages are sources of mediators that have been suggested to participate in the lung damage associated with AP. METHODS: Pancreatitis was induced in rats by intraductal administration of 5% sodium taurocholate. The inflammatory process in the lung and the activation of alveolar macrophages were investigated in animals with and without portocaval shunting 3 hours after AP induction. Alveolar macrophages were obtained by bronchoalveolar lavage. The generation of nitric oxide, leukotriene B4, tumor necrosis factor-alpha, and MIP-2 by alveolar macrophages and the chemotactic activity of supernatants of cultured macrophages were evaluated. RESULTS: Pancreatitis was associated with increased infiltration of neutrophils into the lungs 3 hours after induction. This effect was prevented by the portocaval shunt. Alveolar macrophages obtained after induction of pancreatitis generated increased levels of nitric oxide, tumor necrosis factor-alpha, and MIP-2, but not leukotriene B4. In addition, supernatants of these macrophages exhibited a chemotactic activity for neutrophils when instilled into the lungs of unmanipulated animals. All these effects were abolished when portocaval shunting was carried out before induction of pancreatitis. CONCLUSION: Lung damage induced by experimental AP is associated with alveolar macrophage activation. The liver mediates the alveolar macrophage activation in this experimental model.  (+info)

Examination of the transverse tubular system in living cardiac rat myocytes by 2-photon microscopy and digital image-processing techniques. (3/41636)

The transverse tubular system (t-system) of cardiac muscle is a structure that allows rapid propagation of excitation into the cell interior. Using 2-photon molecular excitation microscopy and digital image-processing methods, we have obtained a comprehensive overview of the t-system of rat ventricular myocytes in living cells. We show that it is possible to quantify the morphology of the t-system in terms of average local tubule diameter, branching pattern, and local abundance of the t-system by immersing living myocytes in a dextran-linked fluorescein solution. Our data suggest that previous electron microscopic examinations of t-system structure have underestimated both the geometric complexity of the t-system morphology and the fraction of cell volume occupied by the t-system (3.6% in this species). About 40% of tubules occur between Z-lines, and the t-tubule diameter is 255+/-0.85 nm (mean+/-SEM). The t-tubules leave the outer surface of the cell in an approximately rectangular array; however, at some points junctions between the t-tubules and the surface membrane are missing. In view of the complexity of the t-system apparent from our images, we propose that the t-system be renamed the "sarcolemmal Z rete." The methods presented here are generally applicable to the quantification of the sarcolemmal Z rete and other structures within cells by fluorescence microscopy in a variety of cell types.  (+info)

Induction of serotonin transporter by hypoxia in pulmonary vascular smooth muscle cells. Relationship with the mitogenic action of serotonin. (4/41636)

-The increased delivery of serotonin (5-hydroxytryptamine, 5-HT) to the lung aggravates the development of hypoxia-induced pulmonary hypertension in rats, possibly through stimulation of the proliferation of pulmonary artery smooth muscle cells (PA-SMCs). In cultured rat PA-SMCs, 5-HT (10(-8) to 10(-6) mol/L) induced DNA synthesis and potentiated the mitogenic effect of platelet-derived growth factor-BB (10 ng/mL). This effect was dependent on the 5-HT transporter (5-HTT), since it was prevented by the 5-HTT inhibitors fluoxetine (10(-6) mol/L) and paroxetine (10(-7) mol/L), but it was unaltered by ketanserin (10(-6) mol/L), a 5-HT2A receptor antagonist. In PA-SMCs exposed to hypoxia, the levels of 5-HTT mRNA (measured by competitive reverse transcriptase-polymerase chain reaction) increased by 240% within 2 hours, followed by a 3-fold increase in the uptake of [3H]5-HT at 24 hours. Cotransfection of the cells with a construct of human 5-HTT promoter-luciferase gene reporter and of pCMV-beta-galactosidase gene allowed the demonstration that exposure of cells to hypoxia produced a 5.5-fold increase in luciferase activity, with no change in beta-galactosidase activity. The increased expression of 5-HTT in hypoxic cells was associated with a greater mitogenic response to 5-HT (10(-8) to 10(-6) mol/L) in the absence as well as in the presence of platelet-derived growth factor-BB. 5-HTT expression assessed by quantitative reverse transcriptase-polymerase chain reaction and in situ hybridization in the lungs was found to predominate in the media of pulmonary artery, in which a marked increase was noted in rats that had been exposed to hypoxia for 15 days. These data show that in vitro and in vivo exposure to hypoxia induces, via a transcriptional mechanism, 5-HTT expression in PA-SMCs, and that this effect contributes to the stimulatory action of 5-HT on PA-SMC proliferation. In vivo expression of 5-HTT by PA-SMC may play a key role in serotonin-mediated pulmonary vascular remodeling.  (+info)

Evidence for a vasopressin system in the rat heart. (5/41636)

Traditionally, a hypothalamo-neurohypophysial system is thought to be the exclusive source of arginine vasopressin (AVP), a potent antidiuretic, vasoconstricting, and growth-stimulating neuropeptide. We have identified de novo synthesis of AVP in the heart as well as release of the hormone into the cardiac effluents. Specifically, molecular cloning of sequence tags amplified from isolated, buffer-perfused, and pressure-overloaded rat hearts allowed the detection of cardiac AVP mRNA. Subsequent experiments revealed a prominent induction of AVP mRNA (peak at 120 minutes, 59-fold, P<0. 01 versus baseline) and peptide (peak at 120 minutes, 11-fold, P<0. 01 versus baseline) in these isolated hearts. Newly induced vasopressin peptide was localized most prominently to endothelial cells and vascular smooth muscle cells of arterioles and perivascular tissue using immunohistochemistry. In addition to pressure overload, nitric oxide (NO) participated in these alterations, because inhibition of NO synthase by Nomega-nitro-L-arginine methyl ester markedly depressed cardiac AVP mRNA and peptide induction. Immediate cardiac effects related to cardiac AVP induction in isolated, perfused, pressure-overloaded hearts appeared to be coronary vasoconstriction and impaired relaxation. These functional changes were observed in parallel with AVP induction and largely prevented by addition of a V1 receptor blocker (10(-8) mol/L [deamino-Pen1, O-Me-Tyr2, Arg8]-vasopressin) to the perfusion buffer. Even more interesting, pressure-overloaded, isolated hearts released the peptide into the coronary effluents, offering the potential for systemic actions of AVP from cardiac origin. We conclude that the heart, stressed by acute pressure overload or NO, expresses vasopressin in concentrations sufficient to cause local and potentially systemic effects.  (+info)

Role of nitric oxide-cGMP pathway in adrenomedullin-induced vasodilation in the rat. (6/41636)

We previously reported that adrenomedullin (AM), a potent vasodilator peptide discovered in pheochromocytoma cells, stimulates nitric oxide (NO) release in the rat kidney. To further investigate whether the NO-cGMP pathway is involved in the mechanisms of AM-induced vasodilation, we examined the effects of E-4021, a cGMP-specific phosphodiesterase inhibitor, on AM-induced vasorelaxation in aortic rings and perfused kidneys isolated from Wistar rats. We also measured NO release from the kidneys using a chemiluminescence assay. AM (10(-10) to 10(-7) mol/L) relaxed the aorta precontracted with phenylephrine in a dose-dependent manner. Denudation of endothelium (E) attenuated the vasodilatory action of AM (10(-7) mol/L AM: intact (E+) -25.7+/-5.2% versus denuded (E-) -7. 8+/-0.6%, P<0.05). On the other hand, pretreatment with 10(-8) mol/L E-4021 augmented AM-induced vasorelaxation in the intact aorta (-49. 0+/-7.9%, P<0.05) but not in the denuded one. E-4021 also enhanced acetylcholine (ACh)-induced vasorelaxation in the rat intact aorta (10(-7) mol/L ACh -36.6+/-8.4% versus 10(-8) mol/L E-4021+10(-7) mol/L ACh -62.7+/-3.1%, P<0.05). In perfused kidneys, AM-induced vasorelaxation was also augmented by preincubation with E-4021 (10(-9) mol/L AM -15.4+/-0.6% versus 10(-8) mol/L E-4021+10(-9) mol/L AM -23.6+/-1.2%, P<0.01). AM significantly increased NO release from rat kidneys (DeltaNO: +11.3+/-0.8 fmol. min-1. g-1 kidney at 10(-9) mol/L AM), which was not affected by E-4021. E-4021 enhanced ACh-induced vasorelaxation (10(-9) mol/L ACh -9.7+/-1.7% versus 10(-8) mol/L E-4021+10(-9) mol/L ACh -18.8+/-2.9%, P<0.01) but did not affect ACh-induced NO release from the kidneys. In the aorta and the kidney, 10(-4) mol/L of NG-nitro-L-arginine methyl ester, an NO synthase inhibitor, and 10(-5) mol/L of methylene blue, a guanylate cyclase inhibitor, reduced the vasodilatory effect of AM. These results suggest that the NO-cGMP pathway is involved in the mechanism of AM-induced vasorelaxation, at least in the rat aorta and kidney.  (+info)

Developmental synaptic changes increase the range of integrative capabilities of an identified excitatory neocortical connection. (7/41636)

Excitatory synaptic transmission between pyramidal cells and fast-spiking (FS) interneurons of layer V of the motor cortex was investigated in acute slices by using paired recordings at 30 degrees C combined with morphological analysis. The presynaptic and postsynaptic properties at these identified central synapses were compared between 3- and 5-week-old rats. At these two postnatal developmental stages, unitary EPSCs were mediated by the activation of AMPA receptors with fast kinetics at a holding potential of -72 mV. The amplitude distribution analysis of the EPSCs indicates that, at both stages, pyramidal-FS connections consisted of multiple functional release sites. The apparent quantal size obtained by decreasing the external calcium ([Ca2+]e) varied from 11 to 29 pA near resting membrane potential. In young rats, pairs of presynaptic action potentials elicited unitary synaptic responses that displayed paired-pulse depression at all tested frequencies. In older animals, inputs from different pyramidal cells onto the same FS interneuron had different paired-pulse response characteristics and, at most of these connections, a switch from depression to facilitation occurred when decreasing the rate of presynaptic stimulation. The balance between facilitation and depression endows pyramidal-FS connections from 5-week-old animals with wide integrative capabilities and confers unique functional properties to each synapse.  (+info)

Differential expression of the mRNA for the vanilloid receptor subtype 1 in cells of the adult rat dorsal root and nodose ganglia and its downregulation by axotomy. (8/41636)

Sensitivity to the pungent vanilloid, capsaicin, defines a subpopulation of primary sensory neurons that are mainly polymodal nociceptors. The recently cloned vanilloid receptor subtype 1 (VR1) is activated by capsaicin and noxious heat. Using combined in situ hybridization and histochemical methods, we have characterized in sensory ganglia the expression of VR1 mRNA. We show that this receptor is almost exclusively expressed by neurofilament-negative small- and medium-sized dorsal root ganglion cells. Within this population, VR1 mRNA is detected at widely varying levels in both the NGF receptor (trkA)-positive, peptide-producing cells that elicit neurogenic inflammation and the functionally less characterized glial cell line-derived neurotrophic factor-responsive cells that bind lectin Griffonia simplicifolia isolectin B4 (IB4). Cells without detectable levels of VR1 mRNA are found in both classes. A subpopulation of the IB4-binding cells that produce somatostatin has relatively low levels of VR1 mRNA. A previously uncharacterized population of very small cells that express the receptor tyrosine kinase (RET) and that do not label for trkA or IB4-binding has the highest relative levels of VR1 mRNA. The majority of small visceral sensory neurons of the nodose ganglion also express VR1 mRNA, in conjunction with the BDNF receptor trkB but not trkA. Axotomy results in the downregulation of VR1 mRNA in dorsal root ganglion cells. Our data emphasize the heterogeneity of VR1 mRNA expression by subclasses of small sensory neurons, and this may result in their differential sensitivity to chemical and noxious heat stimuli. Our results also indicate that peripherally derived trophic factors may regulate levels of VR1 mRNA.  (+info)

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BioAssay record AID 607075 submitted by ChEMBL: Induction of Myod1 mRNA expression in Wistar rat at 60 mg/kg, po qd for 24 days by RT-PCR analysis relative to control.
2 -methylbut-2-ene (2M2B) has a low order of acute toxicity in animals by the dermal and inhalation routes of exposure. It is classifiable as harmful by the oral route of exposure. Non-human data Oral In order to determine the acute oral LD50 of 2M2B a range-finding and definitive study have been performed in albino Wistar rats. In the definitive study, groups of six males and six females were dosed with 1.0, 1.6, 2.5, 4.0, 6.3 and 10 ml/kg. The majority of deaths occurred within the first 3 days following dosing and most survivors had recovered from signs of intoxication by the third day. The author estimated the oral LD50 to be in the range of 1 to 4 ml/kg (i.e., 700 to 2600 mg/kg) (SRC, 1980). Further inspection of the data (OECD SIDS, 2005) allows this to be refined to a range of 1.6 to 2.5 mL/kg (1000 to 1700 mg/kg). Dermal In order to determine the acute dermal LD50 of 2M2B range-finding and definitive studies have been performed in albino Wistar rats. The acute dermal LD50 value of 2M2B ...
seeds on male Wistar albino rats was investigated. The proteins were found to have high true digestibility (TD) and feed conversion ratio (FCR). The net protein retention (NPR), protein efficiency ratio (PER), protein retention efficiency (PRE), Net protein value (NPV), Nitrogen efficiency ratio (NER), feed efficiency ratio (FER) and relative NPR (RNPR) of the ungerminated seeds were significantly lower ( ...
Materials And Methods: A total of 30 male Wistar albino rats weighing 250-280 g were used in this study. In addition, 2-cm-long skin incisions were created over bilaterally exposed skin of the tibia region in each rat. VEGF plasmid 2 μg was administered locally into the right side wound bed of each animal. No other procedure besides skin closure was administered on the left side. To determine histologic assessments, skin samples were obtained from six anesthetized rats at each interval (4, 8, 12, 16 and 30 days) through excisional biopsy. The tissues were fixed in 10% neutral-buffered formalin for 1 week and then embedded in paraffin wax. Transverse sections of the embedded tissue 5-7 μm thick were stained with hematoxylin and eosin (H and E ...
MATERIAL AND METHOD This study was performed on two 6-week male Albino Wistar rats (E1 and E2) bought from Iranian Pasteur Institute. Both experiments were kept in same animal house with a non-enriched environment, 12 hours light/12 hours dark cycle, standard food regimen and water ad libitum. After 18 weeks of keeping, the 24-week experiments were anesthetized by chloroform inhalation and killed with cervical dislocation. The skulls were dissected and cerebella were taken. To fix them, they were emerged in Clark solution for 48 hours. After fixation, the left hemispheres of each of two cerebella were separated from reminder at their junction with relevant vermises. The hemispheres were embedded in paraffin and 6µm parasagittal serial sections were prepared from each of them. For a simple random selection, every 3-5 sections of each hemisphere were mounted on a glass slide. Consequently, a lateral-medial series of slides contained the parasagittal serial sections were provided for each ...
BioAssay record AID 772436 submitted by ChEMBL: Hepatotoxicity in Triton-X-100-induced hyperlipidemia Wistar albino rat model assessed as SGPT level in serum at 250 mg/kg, po qd for 7 days.
Purpose: We have previously shown that delayed injection of bone marrow stem cell conditioned media (BMSC CM), 24 h after ischemia, rescued ischemic retinal functional and histological properties. We hypothesized that preconditioning the BMSC CM by exposure of the BMSCs to hypoxic conditions will increase the efficacy of this protection. In this study we examined the functional and histological outcomes, and the possible mechanisms of this neuroprotection.. Methods: Retinal ischemia was produced in adult Wistar rats by increasing IOP for 55 min. BMSCs which were harvested from male Wistar rat femurs were cultured and characterized. The cultured BMSCs produced hypoxic conditioned media, by exposure to hypoxia (1% O2) for 72 h, which was injected into the vitreous 24 h after the end of ischemia. Recovery was assessed one week later using electroretinography (ERG). Scotopic a- and b waves, oscillatory potentials (OPs) and P2 were measured. We also examined 4 micron thick paraffin-embedded sections ...
In this study, we investigate Nitric oxide synthase (NOS) expressions in adriamycin (ADR)-induced cadiomyopathy in rats. Sixty male Wistar rats were randomly divided into two main groups: control and ADR groups. Myocardial histopathological observation was performed; Expressions of 3 isoforms of NOS genes were examined by RT-PCR analysis; Expressions of 3 isoforms of NOS protein was assessed by Western blot analysis. Myocardium exhibited intensive morphological changes after 8 weeks of ADR treatment. The expression levels of inducible NOS (iNOS) gene and protein were significantly increased in ADRtreated rats after 8 weeks of treatment and then slightly increased at weeks 9 and 10 ...
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Summary The aim of this study was to assess the possible effects of Sa 190 on male and female fertility and embryofetal development after repeated dose administrationin Wistar rats. The test item was administered daily in graduated doses to 3 groups of test animals, one dose level per group for a treatment period of 63 days, i.e. during 14 days of pre-mating and maximum 14 days of mating in both males and females, during the gestation period and up to post-natal day 12 in females. Males were dosed after the mating period until the minimum total dosing period of 28 days were completed. Animals of an additional control group were handled identically as the dose groups but received corn oil, the vehicle used in this study. The 4 groups comprised 10 male and 10 female Wistar rats. Before dosing all females were screened for two weeks for regular estrous cyclicity and animals (10 females/ group) with regular estorus cycle (4-5 day cycle) were used in the study. The following doses were evaluated: ...
Furthermore, the examination of DNA-bound FOXO3a by electrophoretic mobility-shift assay demonstrated a marked increase in nuclear, DNA bound FOXO3a in GK rats with MI compared to Sham-GK and corresponding post-MI Wistar controls (Figure 5D). ...
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A study to evaluate efficacy of Tinospora cordifolia (Guduchi) as analgesic agent using albino wistar rats as an experimental animal model
Twelve 4-week-old male Wistar rats weighing 100 g were fed diets semi-ad libitum for 22 d containing either 1.5% conjugated linoleic acid (CLA-diet) or high oleic sunflower oil (Control-diet). The CLA was structured triacylglycerol with predominantly cis-9, trans-11 and trans-10, cis-12 fatty acid isomers in the inner position and oleic acid in the other positions of the glycerol molecule. The rats were kept individually in metabolic cages. From days 8-16 energy, nitrogen (N) and carbon ...
Background: The use of Jatropha curcas leaves in folklore medicine has gained popularity in recent times due to its medicinal value but without regards to its adverse health effect.. Aim: This study aimed at investigating the effect of J. curcas leaves on the fertility of male Wistar rats.. Methodology: Healthy leaves of J. curcas were harvested, dried and extracted using soxhlet apparatus and ethanol as the solvent. Toxicity test was carried out using standard method. Twenty-four adult male Wistar rats were randomly divided into four groups of six each after seven days acclimatization period. Animals in group 1 were not treated, while those in groups 2, 3 and 4 were administered 100, 200 and 400 mg/kg body weight of J. curcas extracts respectively for twenty-eight days. Administration was done 12 hourly via oral route. At the end of the administration period, the rats were sacrificed after an overnight fast under diethyl ether as anesthesia. Blood samples were collected via cardiac puncture. ...
The present investigation was aimed at evaluating the wound healing potential of aerial parts and roots of Cleome viscosa Linn on albino Wistar rats. Excision and incision models were employed. In each wound model, male albino Wistar rats weighing 180-200g were divided into four groups of 6 animals each. In both the models, group I served as control and group II as reference standard treated with Soframycin. In an excision wound model, group III animals were treated with methanol extract of the aerial parts of C.viscosa (CVAMExt) 500 mg kg/ kg b.w and group IV animals were treated with methanol extract of the roots of C.viscosa (CVRMExt) 500 mg/ kg b.w, for 16 days respectively. In incision wound model, group III and IV animals were treated with CVAMExt and CVRMExt 500 mg/ kg b.w, for 9 days respectively. CVAMExt showed a 91.53% contraction in excision wounds, which was close to the contraction value of the reference drug Soframycin (100%). On the other hand, the same extract used on the incision wound
Abstract Aloe vera has been used since ages to manage a number of diseases causing pain, inflammation and fever. However, its effectiveness has not been scientifically certified. NSAIDs & Opioid are used continuously for the pain management. Alternative analgesics are needed to escape from the serious adverse effects of NSAIDs. Our study demonstrated significant analgesic activity of Aloe vera at doses of 200 mg/kg and 500 mg/kg. Materials and Methods: The study was carried out using Wistar Albino rats (150-200gm). Soxhlets apparatus was used to prepare the aqueous extract of Aloe vera [AEAV]. The animals were divided into 4 groups (n=6) receiving different treatments. Hot plate method, acetic acid induced writhing method and tail flick tests were used. The results were subjected to statistical analysis by using one way ANOVA followed by Dunnetts test. Results Analgesic effect of high dose of AEAV at 500 mg/kg was similar with the standard drug indomethacin. The extract (200 & 500 mg/kg) ...
The present study was designed to investigate the cardioprotective effects of Sundarban honey (SH) in rats with isoproterenol- (ISO-) induced myocardial infarction. Adult male Wistar Albino rats were pretreated with Sundarban honey (5 g/kg) daily for a period of 6 weeks. After the treatment period, ISO (85 mg/kg) was subcutaneously injected into the rats at 24 h intervals for 2 days. ISO-induced myocardial damage was indicated by increased serum cardiac specific troponin I levels and cardiac marker enzyme activities including creatine kinase-MB, lactate dehydrogenase, aspartate transaminase, and alanine transaminase. Significant increases in serum total cholesterol, triglycerides, and low-density lipoprotein-cholesterol levels were also observed, along with a reduction in the serum high-density lipoprotein-cholesterol level. In addition to these diagnostic markers, the levels of lipid peroxide products were significantly increased. The activities of antioxidant enzymes such as superoxide ...
The present study was designed to investigate the cardioprotective effects of Sundarban honey (SH) in rats with isoproterenol- (ISO-) induced myocardial infarction. Adult male Wistar Albino rats were pretreated with Sundarban honey (5 g/kg) daily for a period of 6 weeks. After the treatment period, ISO (85 mg/kg) was subcutaneously injected into the rats at 24 h intervals for 2 days. ISO-induced myocardial damage was indicated by increased serum cardiac specific troponin I levels and cardiac marker enzyme activities including creatine kinase-MB, lactate dehydrogenase, aspartate transaminase, and alanine transaminase. Significant increases in serum total cholesterol, triglycerides, and low-density lipoprotein-cholesterol levels were also observed, along with a reduction in the serum high-density lipoprotein-cholesterol level. In addition to these diagnostic markers, the levels of lipid peroxide products were significantly increased. The activities of antioxidant enzymes such as superoxide ...
Material and methods: Eighty adult male Wistar albino rats were divided into 5 groups. Group I (control group) contained 20 rats, whereas each of the other groups contained 15 rats. These experimental groups were cisplatin group (group II) which received saline injection 5 days prior and after a single cisplatin injection (7 mg/kg IP), cisplatin recovery group (group III) which received saline 5 days before and 21 days after a single cisplatin injection of the same dose. Cisplatin and L-carnitine group (group IV) and cisplatin and L-carnitine recovery group (group V) corresponded to groups II and III respectively in their time design, but L-carnitine was used instead of saline. Liver specimens were subjected to hematoxylin and eosin, Masson trichrome, silver staining as well as immunohistochemical Caspase-3 examination and measurements utilizing image analysis technique ...
Purpose: Enteric glial cells (EGC) exert a critical role in the structural integrity, defense and metabolic function of enteric neurons. Diabetes mellitus (DM) is a chronic disease characterized by metabolic disorders and chronic autonomic neuropathy. Quercetin supplementation, which is a potent antioxidant, has been used in order to reduce the effects of diabetes-induced oxidative stress. The purpose of this research was to investigate the effects of quercetin supplementation in the drinking water at a daily dose of 40 mg on the glial cells and neurons in the jejunum of diabetic rats.Material and Methods: Twenty 90-day-old male adult Wistar rats were split into four groups: normoglycemic control (C), normoglycemic control supplemented with quercetin (Q), diabetic (D) and diabetic supplemented with quercetin (DQ). After 120 days, the jejunums were collected and immunohistochemical technique was performed to label S-100-immunoreactive glial cells and HuC/D-immunoreactive neurons.Results: An intense
The objective of the present study was to examine the effects of prenatal exposure to ethanol on motor performance, emotionality, learning and memory in young-adult, male Wistar rats. Alcohol was delivered to the pregnant dams intragastrically, throughout gestation days (GD) 7-20, at the dose of 6 g/kg/day resulting in the peak blood alcohol concentration (BAC) of 350 mg/dl as assessed on GD 20. Isocaloric intubation and untreated control groups were included. Alcohol exposed rats were not impaired in the rotarod/accelerod tests. Their behavior in the open field and plus maze suggested increased neophobia. Hyperactivity was not observed. In the spatial-navigation task in the water maze, by the middle of the training, fetal alcohol rats showed a tendency towards a slower place acquisition compared to controls, but statistical analysis of the data did not yield between-group differences significant. Towards the end of the training, all rats reached a similar performance level. No detectable ...
Rationale and Objectives 5-HT6 receptors are mainly expressed in brain areas associated with learning and memory. Several studies have reported procognitive effects of both 5-HT6 agonist and antagonists. However, the exact mechanism5 HT6 receptor modulation has not been properly studied especially in the context of cholinergic functions, cerebral blood flow (CBF), brainderived neural factor (BDNF), oxidative stress, and behavioral changes. Methods In the present study, memory impairment was induced in albino Wistar rats by two doses of intracerebroventricular (ICV) injection of treptozotocin (STZ, 3 mg/kg) on first and third day. These rats were evaluated in a battery of behavioral tasks after 14 days from the first day of ICV-STZ.Results Significant memory impairment was seen when ICV-STZ induced rats are assessed by Morris water maze, novel object recognition, social recognition, and passive avoidance tests. There was a significant reduction in CBF, increased oxidative stress (MDA, GSH, and ...
INTRODUCTION Central cardiovascular regulation in haemorrhagic shock is influenced by many neuronal systems, including the melanocortinergic and histaminergic systems. The aim of the study was to examine the involvement of the his-taminergic system in the resuscitating effect of melanocortin type 4 (MC4) receptor agonist Ro 27-3225. MATERIALS AND METHODS Studies were carried out on male Wistar rats subjected to irreversible haemorrhagic shock with a mean arterial pressure (MAP) of 20-25 mmHg. In the 5th minute of critical hypotension, the animals were injected intracere-broventricularly (icv) with Ro 27-3225 or a 0.9% NaCl solution (control group). RESULTS Hypovolaemia was accompanied by a decrease in pulse pressure (PP), heart rate (HR) and renal blood flow (RBF). In the control group, there were no increases in the measured parameters, and a survival rate of 2 h was 0%. Ro 27-3225 (10 nmol, icv) evoked long-lasting rises in MAP, PP and RBF as well as 100% survival at 2 h. Pre-treatment with ...
Nonsynaptic mechanism changes, particularly the enhancement of NKCC1 expression in the dentate gyrus (DG) after 4 weeks of ethanol consumption, motivate the present work, in which rats were submitted to a period of chronic consumption (12 weeks). Four groups of six animals (6-week-old male Wistar rats) were formed, including the control (C), ethanol 1 (El), ethanol 2 (E2) and ethanol 3 (E3) groups. The rats in the El, E2 and E3 groups were treated daily with a 30% v/v solution of ethanol, administered via oral gavage (1.0, 2.0 and 3.0 g/kg, respectively). Nonsynaptic epileptiform activities (NEA) were induced by means of the zero-Ca2+ and high-K+ model using hippocampal slices and were recorded in the DG. The presence of NKCC1, KCC2, a1Na(+)/K+-ATPase and GFAP immunoreactivity was analyzed. The results demonstrate that alcohol consumption changes NEA, and these changes are more prominent at the lower dosage. An increase in the DC shifts associated with epileptiform discharges was present with ...
UNLABELLED Angiotensin II has articularly shown to play a key role in the regulation of inflammatory processes in hypertension. AIM The present study aims to correlate the angiotensin II-induced hypertension 4th systemic inflammation. MATERIAL AND METHODS We conducted an experimental study on Wistar male rats who received Ang II via subcutaneous miniosmotic pumps for 2 weeks. Rats were exposed to a 12h light /12h dark cycle. Sham rats were used as control. Systolic load pressure measurements and a flow cytometric analysis of lymphocyte surface markers were performed. After 14 days, the animals were euthanized under anesthesia with ylazine/ketaniine. RESULTS Systolic BP progressively and significantly increased in rats 4th Ang II chronic infusion. We observed a statistical significant difference (p = 0.00001), in terms of T lymphocytes percentage between control rats plasma and Ang H treated rats lasma, in 14 days. CONCLUSIONS Angiotensin II is an important mediator of hypertension and directly
Electrophysiology. Experiments were performed on posterior hypothalamic slices from 3- to 4-week-old male Wistar rats. After decapitation, the brain was placed in an ice-cold solution made up of (in mm): 208 sucrose, 26 NaHCO3, 10 glucose, 2.1 MgCl2, 1.8 KCl, 1.5 CaCl2, and 1.2 KH2PO4. The solution was bubbled to a pH of 7.4 with a mixture of 95% O2 and 5% CO2. Slices were cut at a thickness of 300-400 μm as described previously (Stevens and Haas, 1996) and transferred to artificial CSF (ACSF), which had the same composition as above except that the sucrose was replaced with 125 mm NaCl. The slices were held in ACSF at room temperature (22-24°C) for at least 1 hr before starting the recording. The slices were then transferred to a thermostat-controlled recording chamber, in which they were submerged in ACSF with a flow rate of 1.8-2.0 ml/min−1 and a temperature of 32-33°C. Intracellular recordings were obtained using sharp glass microelectrodes filled with K+acetate (4 m) with resistances ...
Domestic rats differ from wild rats in many ways: they are calmer and significantly less likely to bite, they can tolerate greater crowding, they breed earlier and produce more offspring, and their brains, livers, kidneys, adrenal glands, and hearts are smaller. Scientists have bred many strains or lines of rats specifically for experimentation. Most are derived from the albino Wistar rat, which is still widely used. Other common strains are the Sprague Dawley, Fischer 344,[8] Holtzman albino strains, Long-Evans, and Lister black hooded rats. Inbred strains are also available but are not as commonly used as inbred mice. Much of the genome of Rattus norvegicus has been sequenced.[9] In October 2003, researchers succeeded in cloning two laboratory rats by nuclear transfer. This was the first in a series of development that have begun to make rats tractable as genetic research subjects, although they still lag behind mice, which lend themselves better to the embryonic stem cell techniques ...
Fourteen 12- to 16-week-old male Wistar rats weighing 200 to 400 g (Scanbur AB, Sollentuna, Sweden) were used. All animals were treated according to the ARVO Statement for the Use of Animals in Ophthalmic and Vision Research. With approval from the Linköping regional animal ethics review board, the rats were anesthetized, and a corneal stromal suture was placed 1.5 mm from the temporal limbus as previously described. 13 A second stromal suture was placed at the 3 oclock position, 1.5 mm from the nasal limbus, to provide additional tissue samples for ex vivo analysis. Left eyes served as negative controls. At 0, 6, and 12 hours and 1, 2, 3, 4, 5, and 7 days after the initial surgery, the rats were anesthetized with intraperitoneal injection of dexmedetomidine (Orion Pharma AB, Sollentuna, Sweden) and xylazine (Pfizer AB, Sollentuna, Sweden), and laser scanning in vivo confocal microscopy (IVCM) of the corneas was performed after topical administration of 1% tetracaine. The number of rats ...
Download Free Full-Text of an article EFFECT OF TAMOXIFEN ON LAYER UTERUS AND THE NUMBER OF OFFSPRINGS IN FEMALE WISTAR RATS in Confrence
Download Free Full-Text of an article EFFECT OF TAMOXIFEN ON THE UTERUS TISSUE, AND PITUITARY-OVARY HORMONAL AXIS IN FEMALE WISTAR RATS in Confrence
Wound healing activity of Cynodon dactylon (L.) Pers. in albino wistar rats By Anand Kumar*1 and Pranita Kashyap2 1Head, Department of Pharmacy, ...
Wound healing activity of Cynodon dactylon (L.) Pers. in albino wistar rats By Anand Kumar*1 and Pranita Kashyap2 1Head, Department of Pharmacy, ...
PURPOSE: To present an animal model to assess the effects of end-to-side innervation in the heterotopically transplanted model with reduced chances of neural contamination.METHODS:The medial portion of the gastrocnemius muscle in wistar male rats was isolated and its pedicle dissected and performed a flap in the abdominal portion. To prevent neural contamination in the abdominal region, the muscle was wrapped with a Goretex(r) sheet. The specimens were divided into 2 groups (G). In G1 was performed an end-to-end suture between tibial nerve of the gastrocnemius and femoral motor nerve and between the saphenous sensory nerve and the motor nerve. In G2 was performed a end-to-side suture between the tibial nerve and the motor femoral and between the tibial nerve and saphenous motor nerve. The specimens were evaluated 60 days later to check the structure of the neurorraphy. Sections were obtained proximal and distal to the coaptation site.RESULTS:The medial gastrocnemius muscle had the advantage of ...
Many methods are used to evaluate ischemia reperfusion injury, but the most employed one is the histological study. However, it only demonstrates on mucosal tunic, the index of lesion and morphologic preserved cells, but not the index of viable functional cells, present in the sample. With this purpose, a colorimetric method was used, employing Methyl Thiazolyl Blue (MTT). The experiment was conducted in 30 Wistar male rats, distributed in 3 groups: Group Control (GC), Group ischemia and reperfusion-1 (GIR-1) and Group ischemia and reperfusion-3 (GIR-3), with 10 animals each. The Groups GIR-1 and GIR-3 were submitted to intestinal ischemia for 30 minutes by a false ligature of superior mesenteric artery, and submitted to euthanasia after 1 and 3 days of reperfusion, when material was picked for absorbency and histological procedures. It was observed a smaller proportion of viable cells and a larger degree of mucosal lesion in GIR-3 group (p,0.05), while GC group was the one with the larger ...
The present study investigated the sensitivity to stress and diazepam in weaning (21-day old) Wistar rats. A single 15-min session of forced swimming was used to induce anxiety-like behavior. The group that was forced to swim exhibited...
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Obsevation: Endotoxic shock is a life-threatening condition and its sequelae represent an array of clinical symptoms that encompass systemic inflammation, coagulopathy, and abnormalities of the renal, hepatic, pulmonary and hematologic systems, followed by multi-organ failure. Furthermore, systemic failure leads to an unfavorable environment in the gut that causes an imbalance in the homeostasis of intestinal microbiota. In the present study, the effect of symbiotics as adjuvant therapy in endotoxic shock was investigated. Adult male Wistar rats were randomized into three groups: Control group received a single intraperitoneal injection of physiological saline solution, and the other two groups received either a symbiotic formulation or a placebo daily, for one week, followed by the administration of a single lethal dose of lipopolysaccharide (LPS) from E. coli (20 mg/Kg, IP). Results: The symbiotic formulation used improved the survival rate of LPS-treated rats, ameliorated the clinical symptomatology,
Obsevation: Endotoxic shock is a life-threatening condition and its sequelae represent an array of clinical symptoms that encompass systemic inflammation, coagulopathy, and abnormalities of the renal, hepatic, pulmonary and hematologic systems, followed by multi-organ failure. Furthermore, systemic failure leads to an unfavorable environment in the gut that causes an imbalance in the homeostasis of intestinal microbiota. In the present study, the effect of symbiotics as adjuvant therapy in endotoxic shock was investigated. Adult male Wistar rats were randomized into three groups: Control group received a single intraperitoneal injection of physiological saline solution, and the other two groups received either a symbiotic formulation or a placebo daily, for one week, followed by the administration of a single lethal dose of lipopolysaccharide (LPS) from E. coli (20 mg/Kg, IP). Results: The symbiotic formulation used improved the survival rate of LPS-treated rats, ameliorated the clinical symptomatology,
In situ hybridisation showing localisation of Mrap, Mrap2 and Mc2r in foetal and adult Wistar rat adrenal glands. (A-G) Foetal Wistar rat adrenal glands (embr
Bumetanide is a selective inhibitor of the Na(+)-K(+)-Cl(-)-co-transporter 1(NKCC1). We studied whether bumetanide could affect axonal growth and behavioral outcome in stroke rats. Adult male Wistar rats were randomly assigned to four groups: sham-operated rats treated with vehicle or bumetanide, and ischemic rats treated with vehicle or bumetanide. Endothelin-1 was used to induce focal cerebral ischemia. Bumetanide administration (i.c.v.) started on postoperative day 7 and continued for 3 weeks. Biotinylated dextran amine (BDA) was injected into the right imotor cortex on postoperative day 14 to trace corticospinal tract (CST) fibers sprouting into the denervated cervical spinal cord ...
Methods. Animals and anesthetics. Animal handling and experimental procedures were reviewed and approved by the ethical committee for animal care and use of the Royal Netherlands Academy for Sciences, acting in accordance with the European Community Council directive of 24 November 1986 (86/609/EEC) and the ARVO statement for the use of animals in Ophthalmic and Vision Research. The procedure to induce transient ischemia followed by reperfusion has been described in detail previously [25-27]. In short, adult male Wistar rats (Harlan, the Netherlands) weighing 200-300 g were anesthetized and mounted onto a stereotactic frame (Stoelting, Wood Dale, IL). A steel 30-gauge infusion needle (BD Biosciences, Alphen aan den Rijn, The Netherlands) connected to a saline reservoir was placed in the middle of the anterior chamber of the left eye. The reservoir was opened and lifted to 1.70 m. Ischemia was confirmed by the white anemic fundus reflex. After 60 min of ischemia, the reservoir was lowered and ...
Affiliation:鶴見大学,歯学部,准教授, Research Field:矯正・小児・社会系歯学,Functional basic dentistry, Keywords:酒石酸耐性酸性ホスファターゼ,adult Wistar rats,骨芽細胞,tension side,osteoblast,tooth movement,破骨細胞,serum BGP,歯の移動,血清BGP, # of Research Projects:5, # of Research Products:0
Myocardial hyperfunction is experimentally modeled by coarctation of the aorta in mature (6-8-month-old) and senescent (26-28-month-old) Wistar rats. During the emergency phase of cardiac...
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An increased incidence of myocardial necrosis or fibrosis was observed in long-term (6-12 months) studies in rats and mice (exposure 8 times human AUC exposure in rats and somewhat equivalent to human Cmax exposure in mice). Findings were not seen at lower doses. In dogs no cardiotoxicity was observed following 12 months of oral dosing at doses that resulted in maximum plasma concentrations (Cmax) 14 times the Cmax exposure in humans receiving a 12 mg/day therapeutic dose or in Wistar rats at Cmax exposures 15 times human Cmax exposure. There is no evidence that similar lesions occur in humans. ...
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In Wistar Rats. Asian Journal of Pharmaceutical and Clinical Research, 5(4), 141-145. Singh V, Kumar R.(2017).Study of ... "Hepatoprotective activity of Clearliv a polyherbal formulation in Wistar rats". Archives of Medicine and Health Sciences. 1 (2 ... Schläppi B (1984). "The lack of hepatotoxicity in the rat with the new and reversible MAO-A inhibitor moclobemide in contrast ... 2015) Antioxidant Activity of The Ancient Herb, Holy Basil in CCl4-Induced Liver Injury in Rats. Ayurvedic 2: 34-38. Ravi V, ...
Hydrated Wistar albino rats Antimicrobial. S. paniculata. Leaves. NA. Bacillus subtilis, Staphylococcus aureus, Enterococcus ... Hydrated rats Antioxidant. S. acmella Murr.. Aerial parts. Chloroform, hexane, ethyl actate, methanol. 2,2-Diphenyl-1- ... Carragenan-induced paw edema in rats Aphrodisiac. S. acmella L. Murr.. Flowers. Ethanol. Nitric oxide release in human corpus ... 2004). "Diuretic activity of Spilanthes acmella flowers in rats". Journal of Ethnopharmacology. 91 (2-3): 317-20. doi:10.1016/j ...
1954 Norwegian pathologist Reidar Eker bred a line of Wistar rats predisposed to renal adenomas. The Eker rat became an ... 1994 The Eker rat was discovered to be an animal model for tuberous sclerosis; it has a mutation in the rat-equivalent of the ... Eker R (1954). "Familial renal adenomas in Wistar rats; a preliminary report". Acta Pathologica et Microbiologica Scandinavica ... In the 1980s, Knudson's studies on the Eker rat strengthened this hypothesis. 1975 Giuseppe Pampiglione and E. Pugh, in a ...
King participated in breeding the Wistar rat, a strain of genetically homogeneous albino rats for use in biological and medical ... Clause, Bonnie Tocher (Summer 1993). "The Wistar Rat as a Right Choice: Establishing Mammalian Standards and the Ideal of a ... Clause, B. T. (February 1998). "The Wistar Institute Archives: Rats (Not Mice) and History". Mendel Newsletter (7): 2-7. PMID ... and served as assistant in anatomy in 1908-09 and as an associate after 1909 at the Wistar Institute. She was also an assistant ...
Singh ND; Sharma AK; Dwivedi P; Patil RD; Kumar M (2007). "Citrinin and endosulfan induced teratogenic effects in Wistar rats ... though it has significant teratogenic effects in laboratory rats. A 2009 assessment concluded the endocrine disruption in rats ... The US EPA classifies it as Category I: "Highly Acutely Toxic" based on a LD50 value of 30 mg/kg for female rats, while the ... and that developmental or reproductive toxicity in rats occurs only at endosulfan doses that cause neurotoxicity. Endosulfan is ...
"Immunotoxicity of ethyl-4-isothiocyanatobutanoate in male Wistar rats". Toxicology. 145 (2-3): 217-25. doi:10.1016/S0300-483X( ... "Immunotoxic and cancerostatic effects of ethyl-4-isothiocyanatobutanoate in female Lewis rats with implanted fibrosarcoma". ...
Kart-Teke E, De Souza Silva MA, Huston JP, Dere E (March 2006). "Wistar rats show episodic-like memory for unique experiences ... Other studies have demonstrated this type of memory in different animal species, such as dogs, rats, honey bees, and primates. ... Eacott MJ, Easton A, Zinkivskay A (2005). "Recollection in an episodic-like memory task in the rat". Learning & Memory. 12 (3 ...
"Mobile phone usage and male infertility in Wistar rats". Indian Journal of Experimental Biology. 48 (10): 987-92. PMID 21299041 ... There was also some evidence of tumors in the brain and adrenal gland of exposed male rats. For female rats, and male and ... This report concludes after the review with an updated statement that "there is clear evidence that male rats exposed to high ... "High Exposure to Radio Frequency Radiation Associated With Cancer in Male Rats". NIEHS;.NIH.gov. National Toxicology Program, ...
"The developmental toxicity of 2-ethylhexanoic acid in Wistar rats". Fundamental and Applied Toxicology. 19 (4): 505-511 - via ... 2-Ethylhexanol exhibits low toxicity in animal models, with LD50 ranging from 2-3 g/kg (rat). 2-Ethylhexanol has been ... Eastman Kodak Company, Eastman Kodak (2009-03-15). "Pharmacokinetic studies with 2-ethylhexanol in the female fischer 344 rat ( ... "Metabolism of 2-ethylhexanol administered orally and dermally to the female Fischer-344 rat". hero.epa.gov. Retrieved 2021-04- ...
"Prenatal developmental toxicity study of n-heneicosane in Wistar rats". Toxicology and Industrial Health. 32 (1): 118-25. doi: ... geraniol and citronellol on rat ileum contraction". Research in Pharmaceutical Sciences. 8 (1): 17-23. PMC 3895296. PMID ...
Alston roots against paracetamol-induced hepatotoxicity in Albino Wistar rats". Journal of Pharmacy Research. 7 (6): 496-501. ...
"Inhalation carcinogenicity study with nickel metal powder in Wistar rats". Toxicology and Applied Pharmacology. 233 (2): 262-75 ... 12035-72-2) in F344 Rats and B6C3F1 Mice (Inhalation Studies)". National Toxicology Program Technical Report Series. 453: 1-365 ... 1313-99-1) in F344 Rats and B6C3F1 Mice (Inhalation Studies)". National Toxicology Program Technical Report Series. 451: 1-381 ... 10101-97-0) in F344 Rats and B6C3F1 Mice (Inhalation Studies)". National Toxicology Program Technical Report Series. 454: 1-380 ...
... of Wistar Rats Revised by Edmyr Rosa dos Reis, et al.. ...
... and C57BL/6N mice and Wistar rats (mammals) via the PGP gene product. Caparrós-Martín JA, McCarthy-Suárez I, Culiáñez-Macià FA ...
... a 52-week dietary toxicity study in Wistar rats]". Shokuhin Eiseigaku Zasshi. Journal of the Food Hygienic Society of Japan. 45 ...
"Studies on the antilithic effect of Rotula aquatica Lour in male Wistar rats". Methods and Findings in Experimental and ...
... and wistar rat. Australian Journal of Zoology 30: 865-875. Orsi, M.A., Ferreira, A.L., de Melo, V.R. & Oliveira, M.C. (1981). ... Reid, B.L. & Cleland, K.W. (1957). The structure and function of the epididymis I. The histology of the rat epididymis. ... I. Temperature and androgen as determinants of the sperm storage capacity of the rat cauda epididymidis. Biology of ... rat) are respectively 4% and 8% of the total length of the duct. Significantly, the low intra-abdominal sperm storage capacity ...
"Thiazolidinedione Treatment Prevents Free Fatty Acid-Induced Insulin Resistance in Male Wistar Rats". Diabetes. 50 (10): 2316- ... Retracted) Hevener, A.; Reichart, D.; Janez, A.; Olefsky, J. (2002). "Female Rats Do Not Exhibit Free Fatty Acid-Induced ...
Ringtail at Rat Guide L.Crippa et al., Ringtail in suckling Munich Wistar Fromter rats: a histopathologic study Ringtail, The ... Ringtail, also known as tail necrosis, is an epidermal disease that may occur in rats, mice, hamsters and other rodents. In ...
Water extracts of I. aquatica showed a blood sugar-lowering effect in Wistar rats. An aqueous juice of 100g plant material was ...
... suppresses ethanol preference in chronically alcoholized Wistar rats". Alcohol. 39 (3): 125-34. doi:10.1016/j.alcohol.2006.08. ... on alcohol intake and motivational properties of alcohol in alcohol-preferring sP rats". Alcohol and Alcoholism. 40 (1): 46-53 ... somatic growth and metabolic parameters in rats". Neuropharmacology. 54 (1): 194-205. doi:10.1016/j.neuropharm.2007.07.004. ...
"Phenobarbital blocks the lung edema induced by centrally injected tityustoxin in adult Wistar rats". Neuroscience Letters. 332 ... In rats, the Tityustoxin caused dramatic effects on the circulatory and respiratory systems, consisting of hypotension, ... in the rat". Toxicon. 15 (3): 225-234. doi:10.1016/0041-0101(77)90048-4. Mesquita, Michel Bernanos Soares; Moraes-Santos, Tasso ... tityustoxin and toxin Ts-γ from Tityus serrulatus scorpion on secretion and structure of the rat submandibular gland". Archives ...
"Chelidonium majus is not hepatotoxic in Wistar rats, in a 4 weeks feeding experiment". Journal of Ethnopharmacology. 126 (3): ... Sanguinarine is particularly toxic with an LD50 of 18 mg per kg body weight (IP in rats). Caffeic acid derivatives, such as ...
3.5% of a dose of dichloroacetylene remains in the corpses of male Wistar rats. The LD50s of mice exposed to dichloroacetylene ... Studies on male rats and rabbits have shown that inhalation of dichloroacetylene can cause tubular necrosis, focal necrosis, ... Inhalation of dichloroacetylene also causes benign tumors of the livers and kidneys of rats. The chemical also caused increased ... While dichloroacetylene is nephrotoxic in rats, it does not show any signs of nephrotoxicity in humans. Dichloroacetylene has ...
de Cássia da Silveira E Sá R, de Oliveira Guerra M (July 2007). "Reproductive toxicity of lapachol in adult male Wistar rats ... Tropical Woods (1925), 1 7-9. Felício AC, Chang CV, Brandão MA, Peters VM, Guerra Mde O (October 2002). "Fetal growth in rats ... Guerra Mde O, Mazoni AS, Brandão MA, Peters VM (February 2001). "Toxicology of Lapachol in rats: embryolethality". Brazilian ...
de Cássia da Silveira E, Sá R, de Oliveira Guerra M (2007). "Reproductive toxicity of lapachol in adult male Wistar rats ... Guerra Mde O, Mazoni AS, Brandão MA, Peters VM (2001). "Toxicology of Lapachol in rats: embryolethality". Brazilian Journal of ... "Fetal growth in rats treated with lapachol". Contraception. 66 (4): 289-93. doi:10.1016/S0010-7824(02)00356-6. PMID 12413627. ...
de Cássia da Silveira E, Sá R, de Oliveira Guerra M (2007). "Reproductive toxicity of lapachol in adult male Wistar rats ... Felício AC, Chang CV, Brandão MA, Peters VM, Guerra Mde O (2002). "Fetal growth in rats treated with lapachol". Contraception. ... Guerra Mde O, Mazoni AS, Brandão MA, Peters VM (2001). "Toxicology of Lapachol in rats: embryolethality". Brazilian Journal of ... ingredients such as lapachol have been found to possess significant abortifacient and reproductive toxicity effects for rats. ...
"A safety assessment of the antimalarial herb Artemisia annua during pregnancy in Wistar rats". Phytotherapy Research. 27 (5): ...
... in Wistar rats". Reprod Toxicol. 18 (6): 819-23. doi:10.1016/j.reprotox.2004.04.011. PMID 15279880. Michler, Barbara; Arnold, ...
This analysis yielded the conclusion that, in their culture of Wistar rat neocortical cells, the AWSR has long rise and fall ... Studies commonly employ rat cortical, hippocampal, and spinal neurons, although lab mouse neurons have also been used. ... Because of their wide availability, neuronal networks are typically cultured from dissociated rat neurons. ...
Ten pregnant female Wistar rats (Rattus norvegicus) were flown. Ground control groups contained the same number of rats. At the ... Additionally eighteen pregnant white rats were sent to be used for studies of the effects of microgravity and radiation. The ... An experiment was conducted to investigate space flight effects on the sensory development of the rats that spent part of their ... rats subsequently produced normal litters. The mission concluded after five days. This was the first time the Soviet space ...
Perez-D'Gregorio RE, Miller RK, Baggs RB (1988). "Maternal toxicity and teratogenicity of tellurium dioxide in the Wistar rat: ...
in carbon tetrachloride induced renal injured Wistar rats: a dose- and time-dependent study" (PDF). Retrieved 19 November 2009. ... seeds in female Sprague-Dawley rats". Niger Postgrad Medical Journal. 9 (2): 95-8. PMID 12163882.. ...
... tricolor extract had anti-inflammatory effect in acute inflammation induced in male Wistar rats.[10] The plant, especially the ...
... weight gain and leptin levels in male Wistar rats". Appetite. 57 (1): 131-133. doi:10.1016/j.appet.2011.04.001. ISSN 1095-8304. ... In rats, appetizers including a ginger or karpurvalli (Coleus aromaticus) beverage were found to improve food consumption.[27] ... There is no neurological explanation as to why chocolate fudge cake evokes more appetite than porridge, but rats are like ... humans in their preference for sweet and/or fatty foods.[1] Rats show a preference for sucrose over sucralose, suggesting the ...
... nädala vanused täiskasvanud Wistar albino male rats (n=40)) antioksüdantseid ja androgeenseid toimeid ning võib forsseerida ... Arash Khaki, Laya Farzadi, Shahin Ahmadi jt, Recovery of spermatogenesis by Allium cepa in Toxoplasma gondii infected rats, ...
Entirely new breeds or "lines" of brown rats, such as the Wistar rat, have been bred for use in laboratories. Much of the ... Other rat genera include Neotoma (pack rats), Bandicota (bandicoot rats) and Dipodomys (kangaroo rats). ... Pet rats are typically variants of the species brown rat - but black rats and giant pouched rats are also sometimes kept. Pet ... Working rats. Main article: Working rat. Rats have been used as working animals. Tasks for working rats include the sniffing of ...
... weight gain and leptin levels in male Wistar rats". Appetite. 57 (1): 131-133. doi:10.1016/j.appet.2011.04.001. ISSN 1095-8304 ... In rats, appetizers including a ginger or karpurvalli (Coleus aromaticus) beverage were found to improve food consumption.[17] ...
The Sprague Dawley rat and Long-Evans rat were developed from Wistar rats. Wistar rats are more active than others like Sprague ... Biobreeding rat[edit]. Main article: Biobreeding rat. Biobreeding diabetes-prone rat (a.k.a. biobreeding rat or BBDP rat) is an ... Long-Evans rat[edit]. The Long-Evans rat is an outbred rat developed by Drs. Long and Evans in 1915 by crossing several Wistar ... Shaking rat Kawasaki was first described in 1988.[36] This and the Lewis rat are well-known stocks developed from Wistar rats. ...
"A safety assessment of the antimalarial herb Artemisia annua during pregnancy in Wistar rats". Phytotherapy research : PTR. 27 ...
"Inhalation carcinogenicity study with nickel metal powder in Wistar rats". Toxicology and Applied Pharmacology. 233 (2): 262-75 ... 12035-72-2) in F344 Rats and B6C3F1 Mice (Inhalation Studies)". National Toxicology Program Technical Report Series. 453: 1-365 ... 1313-99-1) in F344 Rats and B6C3F1 Mice (Inhalation Studies)". National Toxicology Program Technical Report Series. 451: 1-381 ... 10101-97-0) in F344 Rats and B6C3F1 Mice (Inhalation Studies)". National Toxicology Program Technical Report Series. 454: 1-380 ...
O-acetyl-5-hydroxytryptophol and O-acetyl-5-methoxytryptophol in the pineal gland of the male Wistar rat". Reproduction, ... expression of the embryonic variant of the GABA-producing enzyme GAD67 in a coronal brain section of a one-day-old Wistar rat, ... GABA enhanced the catabolism of serotonin into N-acetylserotonin (the precursor of melatonin) in rats.[56] It is thus suspected ... "Putrescine as an important source of GABA in the postnatal rat subventricular zone". Neuroscience. 146 (2): 489-493. doi: ...
"Mobile phone usage and male infertility in Wistar rats". Indian Journal of Experimental Biology. 48 (10).. ... An analysis of an "eagerly anticipated" study using rats and mice by the National Toxicology Program indicates that due to such ... electromagnetic fields activates the mkp-1/ERK pathway and causes blood-brain barrier damage and cognitive impairment in rats" ...
... related improvements of short-term object memory in male Wistar rats". Acta Psychiatrica Scandinavica. 128 (2): 107-13. doi: ...
"Effect of Ruta graveolens and Cannabis sativa alcoholic extract on spermatogenesis in the adult wistar male rats". Indian ... Hadley MA, Lin YC, Dym M (1981). "Effects of gossypol on the reproductive system of male rats". J. Androl. 2 (4): 190-9. doi: ... Adjudin, a non-toxic analog of lonidamine has been shown to cause reversible infertility in rats.[43] The drug disrupts the ... March 2002). "Effect of Sarcostemma acidum stem extract on spermatogenesis in male albino rats". Asian Journal of Andrology. 4 ...
"EFFECT OF 11α-HYDROXYPROGESTERONE ON REPRODUCTIVE SYSTEM OF NORMAL AND PREGNANT ADULT WISTAR RATS*". The Journal of Clinical ... possess hypertensinogenic activity in the rat". Hypertension. 27 (3 Pt 1): 421-5. doi:10.1161/01.hyp.27.3.421. PMID 8698448. ... is weakly anti androgenic in castrate rats. Nguyen, Kim Thoa; Virus, Cornelia; Günnewich, Nils; Hannemann, Frank; Bernhardt, ... confer marked mineralocorticoid activity on corticosterone in the ADX rat". Endocrinology. 136 (4): 1809-12. doi:10.1210/endo. ...
Ocimum gratissimum and Ocimum basilicum in Wistar rats". Food and Chemical Toxicology. 46 (7): 2493-2497. doi:10.1016/j.fct. ...
"Chelidonium majus is not hepatotoxic in Wistar rats, in a 4 weeks feeding experiment". Journal of Ethnopharmacology. 126 (3): ... IP in rats).[14] Caffeic acid derivatives, such as caffeoylmalic acid, are also present.[15] ...
... induced oxidative damage in Wistar rats". J. Appl. Phycol. 23 (2): 257-63. doi:10.1007/s10811-010-9564-0.. ...
... serum prolactin levels and immunoreactive prolactin cells in ovariectomized Wistar rats". Arch. Toxicol. 74 (2): 92-8. doi: ...
Lewis rats show more compulsive lever pressing behavior than Sprague Dawley or Wistar rats and are less responsive to the anti- ... Lever pressing in rats Certain laboratory rat strains that have been created by controlled breeding for many generations show a ... Rats are unable to vomit when they ingest a substance that is harmful thus pica in rats is analogous to vomiting in other ... Also, if rats are restricted both in food intake and wheel access, they will adjust accordingly. In fact, if rats are first ...
O-acetyl-5-hydroxytryptophol and O-acetyl-5-methoxytryptophol in the pineal gland of the male Wistar rat". Reproduction, ... expression of the embryonic variant of the GABA-producing enzyme GAD67 in a coronal brain section of a one-day-old Wistar rat, ... GABA enhanced the catabolism of serotonin into N-acetylserotonin (the precursor of melatonin) in rats.[52] It is thus suspected ... "Adult and embryonic GAD transcripts are spatiotemporally regulated during postnatal development in the rat brain". PLoS ONE. 4 ...
Garcia JH, Liu KF, Ho KL (1995). "Neuronal necrosis after middle cerebral artery occlusion in Wistar rats progresses at ...
... from which matuzumab was derived was developed at the Wistar Institute in Philadelphia, Pennsylvania [2] ... Rat/mouse hybrid. ("-tumaxo-"). *Catumaxomab. *Ertumaxomab§. Chimeric + humanized. ("-tuxizu-"). *Depatuxizumab mafodotin†. * ...
"Triclosan exposure modulates estrogen-dependent responses in the female wistar rat." Toxicol Sci. 2010 Sep;117(1):45-53. doi: ... Studies on rats have shown that triclosan exposure modulates estrogen-dependent responses.[55] There have been many studies ... performed over the years both in vivo and in vitro, in male and female fish and rats and they all support the conclusion that ...
The 10-day LD50 in Wistar rats is 166 mg/kg in males, 120 mg/kg in females, and 60-65 mg/kg for ip. administration in males. ... Rats fed 5-10 mg/kg of sterigmatocystin for two years showed a 90% incidence of liver tumours. It has been suggested that ... Chronic symptoms include induction of hepatomas in rats, pulmonary tumours in mice, renal lesions and alterations in the liver ... Skin and hepatic tumours are induced in rats by dermal application. Cattle exhibiting bloody diarrhoea, loss of milk production ...
... seventy Wistar rats (35 males and 35 females) weighing 150 ± 50 g were divided into seven groups and each group had 10 rats (5 ... Subacute Toxicity Profile of Lacidipine Nanoformulation in Wistar Rats. Rupesh Shirodkar,1 Chandrasekhar Misra,2 Chethan GH,2 ... The study was carried out on both male and female Wistar rats aged between seven and eight weeks, supplied by Central Animal ... P. Sharma, R. Singh, and M. Jan, "Dose-dependent effect of deltamethrin in testis, liver, and Kidney of wistar rats," ...
... on cutaneous wound healing in Wistar rats. Forty Wistar rats were divided into two groups: control and DP groups. The skin on ... Dracorhodin Perchlorate Accelerates Cutaneous Wound Healing in Wistar Rats. Xiao-wen Jiang, Lu Qiao, Lin Liu, Bin-qing Zhang, ... Forty healthy adult male Wistar rats (Harbin Medical University in Harbin, China) weighing g were maintained under standard ... DP can induce complete wound healing in our Wistar rat model. DP can inhibit IL-1α and TNF-α secretion to reduce inflammation ...
Therefore, the metabolism of myosmine has been studied in Wistar rats treated with single oral doses of [pyridine-5-3H]myosmine ... Previous Document: Modulation of P-glycoprotein expression in hyperthyroid rat tissues.. Next Document: More than just water ...
Biological context of Rats, Wistar. *All Wistar rats treated with 5 mg/kg per d of dexamethasone for 24 d exhibited increased ... Disease relevance of Rats, Wistar. *Production of adenocarcinomas of the small intestines of Wistar rats fed panfuran-S ... Analytical, diagnostic and therapeutic context of Rats, Wistar. *Micropuncture studies were performed in Munich Wistar rats ... of the gastric wall were investigated in spontaneously hypertensive rats and in control Wistar Kyoto rats and Wistar rats [18]. ...
To test these hypotheses, plasma glucose and insulin levels were measured in obese prediabetic Wistar-Fatty rats after two ... Repeated weight fluctuation increases plasma insulin in the obese Wistar fatty diabetic rat.. Stein LJ1. ... Together, these results suggest that insulin resistance of Wistar-Fatty rats was worsened by repeated weight fluctuation. ... Following two cycles of weight loss and regain, glucose levels did not differ between weight-cycled rats and static weight ...
The effects of triclosan on puberty and thyroid hormones in male Wistar rats.. Zorrilla LM1, Gibson EK, Jeffay SC, Crofton KM, ... Weanling rats were exposed to 0, 3, 30, 100, 200, or 300 mg/kg of triclosan by oral gavage from postnatal day (PND) 23 to 53. ... Rats were killed on PND 53, organ weights were recorded and serum was collected for subsequent analysis. Triclosan did not ... triclosan exposure significantly impacts thyroid hormone concentrations in the male juvenile rat. ...
... in striatum of rats. We also evaluated the effect of cell death parameters (necrosis and apoptosis). Wistar rats of 60 days of ... Hypoxanthine Induces Neuroenergetic Impairment and Cell Death in Striatum of Young Adult Wistar Rats. ... Leong SF, Lai JCK, Lim L, Clark JB (1981) Energy-metabolising enzymes in brain regions of adult and aging rats. J Neurochem 37: ... Bavaresco CS, Chiarani F, Kolling J et al (2008) Biochemical effects of pretreatment with vitamins E and C in rats submitted to ...
Animals: Laboratory bred Wistar rats of either sex were used for the experiments. The animals were housed and acclimatized to a ... Rats of group 1 received 10 ml/kg b.wt. of vehicle (water) and served as control. Rats of groups 2, 3 and 4 received PartySmart ... Rats of group 1 received 10 ml/ kg b.wt. of vehicle (water) and served as control. Rats of groups 2 and 3 received PartySmart ... Sixty rats were divided into 3 groups of 20 rats each in a randomized manner with equal number of males and females in each ...
We performed an acute toxicity study in Wistar rats with the prototype liver toxin; the acetaminophen (APAP) effects on protein ... Some of the liver drug metabolizing and detoxifying enzymes were depleted under toxic conditions compared with non-toxic rats. ... The identified proteins in toxicity-induced rats were classified based on their putative protein functions, which are oxidative ... stress and immunity-related proteins were up-regulated in toxicity-induced rats as compared with nontoxic and control rats. ...
Purpose The aim was to investigate the impact of hypercholesterolemic diet on the metabolome of male Wistar rats by a ... Male Wistar rats were fed with two different diets [control (C) and high-cholesterol diet (HC)-containing 2 % cholesterol and ... The aim was to investigate the impact of hypercholesterolemic diet on the metabolome of male Wistar rats by a multiplatform ... HC feeding stimulated the alteration of multiple pathways in Wistar rats, warning of the risk of developing important diseases ...
... rats wistar include Kinematics and Ground Reaction Force Determination: A Demonstration Quantifying Locomotor Abilities of ... Young Adult, Middle-aged, and Geriatric Rats, Touchscreen Sustained Attention Task (SAT) for Rats, Investigation of ... Rats, Wistar: A strain of albino rat developed at the Wistar Institute that has spread widely at other institutions. This has ... Touchscreen Sustained Attention Task (SAT) for Rats. Debra A. Bangasser1,2, Brittany Wicks1, David E. Waxler1, Samantha R. Eck1 ...
Buy a discounted Hardcover of Dieseases of the Wistar Rat online from Australias leading online bookstore. ... Booktopia has Dieseases of the Wistar Rat by Mary J. Tucker. ... This text provides a complete account of this particular rat ... Incidence levels are provided for all diseases and these are compared with published data for other rat strains. ...
Wistar" by people in Harvard Catalyst Profiles by year, and whether "Rats, Wistar" was a major or minor topic of these ... "Rats, Wistar" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical Subject ... A strain of albino rat developed at the Wistar Institute that has spread widely at other institutions. This has markedly ... Below are the most recent publications written about "Rats, Wistar" by people in Profiles. ...
Wistar Hannover GALAS rats are no longer in live production. ... Formerly used in toxicology and as an all-purpose outbred rat ... The rats were derived by caesarean in 1999. Taconic replaced its previous Wistar Hannover stock with Wistar Hannover GALAS™ in ... The rats were derived by caesarean in 1989. Taconic received breeding stock from RCC in 1998. The rats were refreshed with ... Weighs less than SD rats but comparable to SD rats in reproductive performance ...
Exercise Improves Insulin and Leptin Sensitivity in Hypothalamus of Wistar Rats. Marcelo B.S. Flores, Maria Fernanda A. ... Exercise Improves Insulin and Leptin Sensitivity in Hypothalamus of Wistar Rats. Marcelo B.S. Flores, Maria Fernanda A. ... Male Wistar rats (200-250 g) from the University of Campinas Central Animal Breeding Center were used in the experiments. All ... Tissue extracts from control rats, exercised rats, and exercised rats pretreated with anti-IL-6 were treated with leptin and ...
Wistar rats. Partial least square-discrimination analysis (PLS-DA) and a variance im portance in projection (VIP) score was ... Laboratory rats are the most popular animals in toxicology, neurobehavioral, or cancer research. Our study aimed to reveal the ... Our study provides an important insight into sex-specific differences in energy metabolism in rats and indicates that further ... Sexual Dimorphism in Energy Metabolism of Wistar Rats Using Data Analysis by Andrea Leskanicova 1, Olga Chovancova 2, Marian ...
The brains of 396 old albino rats of the breed Wistar-AF/Han-EMD were examined for spontaneous tumors of the CNS and the ... The incidence of spontaneous tumors of the central nervous system of Wistar rats Arch Toxicol. 1976 Jan 30;35(1):1-13. doi: ... The brains of 396 old albino rats of the breed Wistar-AF/Han-EMD were examined for spontaneous tumors of the CNS and the ... that certain chemical compounds like for instance N-methyl-N-nitrosourea induce organ-specific tumors in the brain of rats. It ...
The incidence of carcinoma in irradiated rats was higher in WF rats than SD rats through the course after the irradiation, ... The incidence of carcinoma in irradiated rats was higher in WF rats than SD rats through the course after the irradiation, ... ETDEWEB / Search Results / Spontaneous and x-irradiation induced carcinomas of small intestine in Wistar-Furth rats ... Spontaneous carcinoma of the small intestine in Wistar-Furth (WF) rats and carcinoma of the small intestine induced by local x- ...
... Prog Neuropsychopharmacol Biol Psychiatry. 2010 May 30;34(4):605-9. ... Based on this claim, the present study investigated the effects of Citrus sinensis (sweet orange) essential oil on Wistar, male ... rats evaluated in the elevated plus-maze followed by the light/dark paradigm. The animals were exposed to the orange aroma (100 ...
Conversely, nondiabetic BB-Wistar rats made diabetic with streptozocin (STZ) and maintained in a hyperglycemic state did not ... A similar defect in catecholamine secretion was also seen in adrenals harvested from nondiabetic BB-Wistar rats following a 3-h ... We have demonstrated previously that spontaneously diabetic BB-Wistar rats exhibit decreased adrenal medullary catecholamine ... Decreased Adrenal Medullary Catecholamine Release in Spontaneously Diabetic BB-Wistar Rats: Role of Hypoglycemia. ...
... and the ensuing response to naltrexone in Wistar rats from three different suppliers. The results showed that outbred Wistar ... WI rats relative to HanTac:WH and Crl:WI rats. Overall these findings render RccHan™:WI rats more suitable for studies of ... Male Wistar rats from three different suppliers (Harlan Laboratories B.V., RccHan™:WI; Taconic Farms A/S, HanTac:WH; and ... Moreover, the Rcc Wistar rats may be more suitable for studies of alcohol use disorders due to increasing alcohol intake and ...
15 wistar rats were divided in 3 groups: Rats that used BP was named G1; Rats that used GT was named G2; and rats with only ... defect with PB and GT patches to compare histologically the tissue interaction between them and diaphragm in young Wistar rats ... 15 wistar rats were divided in 3 groups: Rats that used BP was named G1; Rats that used GT was named G2; and rats with only ... Shows BP patch between the diaphragm and the liver (L) of the Wistar rat with lymphocytic infiltrate (Li) between the D and BP ...
Quantitative immunohistochemical analysis of duodenal ghrelin cells after sleeve gastrectomy in Wistar rats1 ... We analyzed the first 5 cm of the duodenum in two groups of six Wistar rats at 30 and 60 days after SG, and because of the ... Eighteen adult male Wistar rats weighing 250-350g were used in this experiment. The animals were randomly allocated into three ... METHODS: Twelve adult male, Wistar rats underwent SG and were reoperated 30 or 60 days after the initial surgery. During the ...
Substantial work has shown that rats although identical in stock, sex, age, and housing conditions can differ considerably in ... Rats. Rats, Wistar. Species Specificity. Temperament / physiology*. From MEDLINE®/PubMed®, a database of the U.S. National ... As in our previous work, we used the degree of rearing activity in a novel open field to assign male adult outbred Wistar rats ... Furthermore, HRA rats visited more arms and made relatively less reference memory errors than LRA rats. This allowed them to ...
... 1 ... To carry out the study, it was used 30 male Wistar rats (Rattus norvegicus albinus), between 90 and 120 days of age and average ... METHODS: In thirty male Wistar rats, 30 days before surgical procedure when round defects would be created on the bone, the ... Platelet-rich plasma in bone repair of irradiated tibiae of Wistar rats. Acta Cir Bras. 2010;25(3):257-63. [ Links ]. ...
If you are a society or association member and require assistance with obtaining online access instructions please contact our Journal Customer Services team ...
Wistar rats with 307 ± 21 g average weight were used. These were divided in two groups of five rats each. All rats underwent ... Evolution of experimental acute pancreatitis in Wistar rats that underwent vagotomy. Cir Cir 2002; 70 (4) ... Use of vagotomy improves the course of experimental acute pancreatitis in early stages in Wistar rats. ... All rats were sacrificed and submitted to excision of pancreas for histopatologic study. Results: Both groups had similar basal ...
... on Wistar rats. The study was based on the gavage administration of the ethylic extract of Tl with different doses (i.e. 200, ... Moreover, when compared to the control rats, the animals treated with 5000 mg/kg of the extract exhibited significant reduction ... results of the psychotropic test conducted during this study showed visible effects on the exploratory activity of the rats. ... Evaluation of Acute Toxicity and Sedative Effects of Ethylic Extract of Thymelaea lythroides in Wistar Rats ...
Dose-and Sex-related Carcinogenesis by N-Bis(2-hydroxypropyl)nitrosamine in Wistar Rats * * MOREIRA Eduarodo L. T. ... Effects of uracil calculi on cell growth and apoptosis in the BBN-initiated Wistar rat urinary bladder mucosa OLIVEIRA S. ... Thymic lymphomas in Wistar rats exposed to N-methyl-N-nitrosourea (MNU) ... Effect of Dose on the Carcinogenic Activity of Orally Administered N-BIS(2-Hydroxypropyl)Nitrosamine in Rats [in Japanese] ...
Wistar rats, an animal strain widely used in the research have been employed to study the effects of dietary interventions due ... Here we provide a temporal course on lipid profile of cholesterol, triglycerides, HDL and LDH in Wistar rats treated with CED ... suggesting that young rats have a compensatory effect at least for the period of time analyzed here. ... Wistar rats, an animal strain widely used in the research have been employed to study the effects of dietary interventions due ...
  • A strain of albino rat developed at the Wistar Institute that has spread widely at other institutions. (harvard.edu)
  • The brains of 396 old albino rats of the breed Wistar-AF/Han-EMD were examined for spontaneous tumors of the CNS and the following tumors were diagnosed: 1 oligodendroglioma, 1 astrocytoma, 1 mixed glioma, 1 pleomorphic glioma, and 19 meningiomas. (nih.gov)
  • Protective effects of melatonin and omega-3 on the hippocampus and the cerebellum of adult Wistar albino rats exposed to electromagnetic fields. (stopumts.nl)
  • The purpose of the study was to investigate the effects of pulsed digital electromagnetic radiation emitted by mobile phones on the central nervous system of the adult Wistar albino rats. (stopumts.nl)
  • The study investigated the effect of Theobroma cacao on renal function of phenylhydrazine induced anaemic albino rats. (academicjournals.org)
  • Forty albino rats were divided into 8 groups of five rats each namely control (group A), Phenyl hydrazine (group B) while groups C, D and E were given phenylhydrazine and administered with 100,200 and 500 mg/kg of T. cacao respectively while groups F, G and H were given 200,500 and 1000 mg/kg of T cacao only. (academicjournals.org)
  • Healthy male albino Wistar rats were exposed to RF-EMR by giving 50 missed calls (within 1 hour) per day for 4 weeks, keeping a GSM (0.9 GHz/1.8 GHz) mobile phone in vibratory mode (no ring tone) in the cage. (buergerwelle.de)
  • Eighty pregnant Wistar albino rats weighing 180 g to 200 g body weight were used. (omicsonline.org)
  • A total of fifty Wistar albino rats weighing 50-60g were randomly allocated to five dietary treatments in a completely randomized design to investigate the haematology, serum biochemistry and organ weight changes on diets containing processed dehulled jack bean. (ajol.info)
  • Effects of mobile phone radiation on serum testosterone in Wistar albino rats. (emf-portal.org)
  • This study was undertaken to provide preliminary evidence for beneficial effects of both bilateral as well as unilateral caloric vestibular stimulation as an alternative therapy for enhancement of cognition and motor activity in Scopolamine induced dementia in Wistar albino rats. (alliedacademies.org)
  • 36 healthy, adult male Wistar albino rats with body weight ranging from 150-200 g were used in the current study. (alliedacademies.org)
  • Methods: Male Wistar rats aged 8 10 weeks were orchiectomized and put on a low- (diet 0.03% NaCl+tap water) or high-salt diet (diet 4% NaCl+trinking water 0.09% NaCl) over 5 weeks. (endocrine-abstracts.org)
  • However, all the processing methods were ineffective when compared to the performance of rat fed casein based diets. (ajol.info)
  • Methods: Thirty-day-old female Wistar rats were submitted to IF for three months. (endocrine-abstracts.org)
  • Materials and Methods: A total of twenty five (25) male Wistar rats were divided into five groups as follows: Group 1 (Control) received distilled water (0.2 ml/100 g i.p.) for 5 consecutive days and thereafter left untreated for 28 days. (scopemed.org)
  • Methods and results: We determined the effect of piperine, quercetin, and polysorbate 80 coadministered with losartan on plasma levels in rats by HPLC assay. (eurekaselect.com)
  • Methods: The following oral treatments were given to diabetic rats for 30 days: (1) metformin 500 mg/kg, (2) baicalin 120 mg/kg, and (3) metformin 500 mg/kg & baicalin 120 mg/kg, with vehicle-treated diabetic and non-diabetic groups serving as controls. (nus.edu.sg)
  • Pancreas is a preeminent source of ghrelin after sleeve gastrectomy in Wistar rats. (medworm.com)
  • 20 adult male Wistar rats were randomly divided into 5 groups. (academicjournals.org)
  • Rats were divided into 5 groups (n=12,8 rat in each group),three group of rats gavaged with doses of 200,400 and 600μg/kg B.W Tamoxifen dissolved in solvent(ethanol 60% and physiological solution) for 30 days. (sid.ir)
  • Varying dosage and long administration of sildenafil citrate may have some deleterious effects on the neurons of the intracranial visual relay centre and this may probably have some adverse effects on visual sensibilities by its deleterious effects on the cells of the lateral geniculate body (LGB) of adult Wistar rats. (cogprints.org)
  • This study aims to establish an experimental model of correction for large diaphragmatic defect with PB and GT patches to compare histologically the tissue interaction between them and diaphragm in young Wistar rats. (scirp.org)
  • Cortés-Ortiz, M. , Leal-Galicia, P. , Chávez-Álvarez, B. , Cárdenas-Aguayo, M. and Meraz-Ríos, M. (2014) Effect of Cholesterol Enriched or Fatty-Acid Diets on Cholesterol and Lipid Levels in Young Wistar Rats. (scirp.org)
  • Arterial wall and smooth muscle cell development in young Wistar rats and the effects of surgical denervation. (ahajournals.org)
  • H. Illnerova, J. Vaneek and K. Hoffmann, "Regulation of the Pineal Melatonin Concentration in the Rat (Rattus norvegicus) and the Djungarian hamster (Phodopus sungorus)," Comparative Biochemistry and Physiology, Vol. 74, No. 1, 1983, pp. 155-159. (scirp.org)
  • LCDP was also tested in normotensive rats and results obtained from chemistry analysis revealed slight variations in the levels of creatinine kinase (CK), serum glutamate oxaloacetic transaminase (SGOT), and alanine transaminase (ALT) levels. (hindawi.com)
  • Rats were killed on PND 53, organ weights were recorded and serum was collected for subsequent analysis. (nih.gov)
  • The Roux-en Y Gastric Bypass showed neither epsilon cell increase nor basal serum changes in ghrelin release. (medworm.com)
  • The feeding trial lasted for 28 days after which four rats per treatments were sampled to evaluate haematological and serum biochemical indices while three rats per treatment were sacrificed by cervical decapitation and the heart, liver, kidneys and the lungs removed and weighed separately. (ajol.info)
  • Rats on T3 and T5 had the highest value for heart weight (0.75) and liver weight (5.67)while rats on T4 had the highest value for lungs (1.59).Rats fed dehulled jack bean seed soaked in ogi liquor showed slight improvement on haematological, serum profile and organ weight changes over those fed lye soaked jack bean and boiled for 15minutes. (ajol.info)
  • To study the effects of electromagnetic fields generated by mobile phones on serum testosterone levels in rats . (emf-portal.org)
  • The data showed that exposure to mobile phones for 60 minutes/day for the total period of 3 months significantly decreased the serum testosterone level in rats compared to the control group . (emf-portal.org)
  • Effects of simultaneous combined exposure to CDMA and WCDMA electromagnetic fields on serum hormone levels in rats. (emf-portal.org)
  • Innovative Grade US Origin Rat Wistar Complement Serum from Innovative Research is manufactured using whole blood collections from type Wistar rats. (innov-research.com)
  • Since hypoxanthine is a purine closely related to ATP formation, the aim of this study was to investigate the effect of intrastriatal hypoxanthine administration on neuroenergetic parameters (pyruvate kinase, succinate dehydrogenase, complex II, cytochrome c oxidase, and ATP levels) and mitochondrial function (mitochondrial mass and membrane potential) in striatum of rats. (springer.com)
  • Narayanaswamy M, Piler MB (2010 Jan) Effect of maternal exposure of fluoride on biometals and oxidative stress parameters in developing CNS of rat. (fluoridealert.org)
  • This study was aimed at determining the effects of the ethanolic extract of the whole fruit of Lagenaria breviflora Robert on male fertility by evaluating some andrological parameters of the Wistar rat such as morphology of spermatozoa, sperm count, motility, liveability and volume of the semen. (academicjournals.org)
  • Acid secretory parameters like gastric volume, pH, total acidity and free acidity were measured in pylorus ligation model, whereas numbers of ulcers, ulcers score and ulcer index was measured in pylorus ligated and indomethacin treated rats. (ijpsonline.com)
  • The purpose of this study was to determine the effects of 8-week testosterone enanthate (TE) injections in high and low doses and resistance training (RT) on hematological parameters in male rats. (springermedizin.de)
  • Thus, the aim of this study was to evaluate, in a subchronical study, the effects of ingestion of MSG through the diet at levels of 1.0%, 2.5% and 5.0% on the biochemical, hematological and histological parameters, on male diabetic and non-diabetic Wistar rats. (scirp.org)
  • Fish oil supplementation improved liver phospholipids fatty acid composition and parameters of oxidative stress in male Wistar rats. (semanticscholar.org)
  • In the present study, we examined the effects of fish oil supplementation in 3 months old male Wistar rats on changes in plasma and liver lipid metabolism and oxidative stress parameters. (semanticscholar.org)
  • The present study was designed to investigate the pharmacodynamics and oral toxicity of PartySmart, a herbal formulation in rats. (redorbit.com)
  • It is evident that the percentages of oxidative stress and immunity-related proteins were up-regulated in toxicity-induced rats as compared with nontoxic and control rats. (mdpi.com)
  • The purpose of this study was to evaluate the acute toxicity and sedative effect of the ethylic extract of Thymelaea lythroides ( Tl ) on Wistar rats. (scirp.org)
  • This study is designed to elucidate the chemopreventive properties of 18β-GA against 2-AAF-induced liver toxicity in Wistar rats and evaluated its effect on inflammatory and tumour promotion marker and activities of different oxidative stress enzymes. (sigmaaldrich.com)
  • Due to the elevated Mean corpuscular volume (MCV) and the normal values of the mean corpuscular Haemoglobin concentration (MCHC) in all the treatment groups the toxicity of H. Sabdariffa seed to Wistar rats resulted in macrocytic normochromic type of anaemia. (nepjol.info)
  • Vara Prasad WLNV, Srilatha Ch, Sailaja N, Raju NKB, Jayasree N (2016) Amelioration of gamma-hexachlorocyclohexane (lindane) induced renal toxicity by Camellia sinensis in Wistar rats, Veterinary World, 9 (11): 1331-1337. (veterinaryworld.org)
  • Cadmium-Induced Testicular Toxicity, Oxidative Stress and Histopathology in Wistar Rats: Sustained Effects of Polyphenol-Rich Extract of Vernonia Amygdalina (Del. (scopemed.org)
  • Aim: To determine the effects of polyphenol-rich extract of the leaf of Vernonia amygdalina (PEVA) on Cd-induced testicular toxicity, oxidative stress, and histopathology in Wistar rats. (scopemed.org)
  • These findings suggest that MON810 has negligible effects on the small intestine of rats at the cellular level compared with the well-documented toxicity observed in susceptible insects. (dtu.dk)
  • The data from a total of 841 Wistar rats (418 males and 423 females) and 144 beagle dogs (72 males and 72 females) was used from placebo/vehicle treated control group of different non-clinical toxicity studies. (avmi.net)
  • Collectively, the data describe decreased adrenomedullary response to cholinergic stimulation in spontaneously diabetic rats as early as 2 weeks after the onset of diabetes and that a similar, although more severe, hyposecretion occurs after acute, severe hypoglycemia. (diabetesjournals.org)
  • To determine the effect of vagotomy in early stages of experimental acute pancreatitis induced by occlusion of pancreatic duct in Wistar rats. (medigraphic.com)
  • Use of vagotomy improves the course of experimental acute pancreatitis in early stages in Wistar rats. (medigraphic.com)
  • In this study, we hypothesized that acute and prolonged conditional microglial ablation in a rat model would lead to improvements in learning and memory and that this would be associated with changes in synaptic pruning and neuronal maturation. (springer.com)
  • Kari HP, Davidson PP, Kohl HH, Kochhar MM (1978 Jun) Effects of ketamine on brain monoamine levels in rats. (fluoridealert.org)
  • The highly elevated aldosterone levels in rats on low salt diet with spironolactone or flutamide treatment were reduced by androgen treatment. (endocrine-abstracts.org)
  • After 7 weeks of experimental feeding, the rats were euthanized for blood collection and plasma recovery. (springer.com)
  • Effects of Opium Dependency on Testicular Tissue in a Rat Model: An Experimental Study. (harvard.edu)
  • For the current experimental study, the Wistar rats were used and an intraperitoneal dose of DEN (200 mg kg 1 ) was given to them for the induction of HCC. (scialert.net)
  • To investigate the potential therapeutic effect of this broad-spectrum chemokine antagonist, we studied the antiinflammatory activity of vMIP-II in a rat model of experimental glomerulonephritis induced by an antiglomerular basement membrane antibody. (rupress.org)
  • Incidence levels are provided for all diseases and these are compared with published data for other rat strains. (booktopia.com.au)
  • In the irradiation with 1,000 R, carcinogenesis was not found in rats of both strains. (osti.gov)
  • To investigate mechanisms involved in hepatic ODN transport, normal mixed backbone phosphodiester/phosphorothioate ODNs ( n -ODN) and two different bile acid-conjugated mixed backbone ODNs (1BA-ODN and 2BA-ODN) were applied to two different rat strains, normal Wistar rats and Wistar TR - rats. (ovid.com)
  • Compared with Wistar-Kyoto rats (WKY), spontaneously hypertensive rats (SHR) demonstrated low urine concentration ability and resistance to vasopressin in a state of dehydration (DH). (ahajournals.org)
  • 1. Previous studies have indicated that increases in dietary K + promote diuresis and retard stroke development in stroke-prone spontaneously hypertensive rats (spSHR) fed a Japanese-style diet containing 4% NaCl. (portlandpress.com)
  • Yan N, Liu Y, Liu S, Cao S, Wang F, Wang Z, Xi S (2016) Fluoride-induced neuron apoptosis and exvpressions of inflammatory factors by activating microglia in rat brain. (fluoridealert.org)
  • The present study was aimed at investigating the safety of Lacidipine (LCDP) loaded nanostructured lipid carriers (NLCs) in Wistar rats. (hindawi.com)
  • Here we provide a temporal course on lipid profile of cholesterol, triglycerides, HDL and LDH in Wistar rats treated with CED and FAD diet that can be useful as reference for future studies. (scirp.org)
  • In this study liver nodules were produced in Wistar rats by intermittent feeding with dietary 2-acetylaminofluorene, and the lipid compositions of isolated microsomes, mitochondria, and lysosomes were examined. (aacrjournals.org)
  • However, in Gr.II rats,there was an increase in protein content, glutathione and antioxidant enzyme levels,tryptophan-fluorescence and inhibition in AGE-fluorescence and lipid peroxidation.In the tryptohan deficient animals the enzymatic degradation of tryptophan by IDO has been significantly reduced and therefore, it decreased the anti-oxidative effects of IDO itself. (arvojournals.org)
  • The present study was aimed at evaluating the mitigating effect of vitamin C on chronic CPF-evoked alteration in lipid profiles in Wistar rats. (thescipub.com)
  • however, triclosan exposure significantly impacts thyroid hormone concentrations in the male juvenile rat. (nih.gov)
  • Adrenal catecholamine release in response to ACh was significantly decreased at 2, 8, and 16 weeks after the onset of diabetes compared with age-matched, nondiabetic control rats. (diabetesjournals.org)
  • The decreased responsiveness of diabetic rat adrenals to perfusion with ACh was significantly correlated with a decrease in the release of catecholamines in response to splanchnic nerve stimulation. (diabetesjournals.org)
  • Tissue fluoride levels of the hippocampus, neocortex, cerebellum, spinal cord, and sciatic nerve increased significantly in fluoride fed rats. (fluoridealert.org)
  • 3. The onset of stroke, as well as death resulting from stroke, occurred at a significantly later age in spSHR fed a high K + diet than in spSHR fed a low-K + diet, despite the fact that both groups of spSHR rats had comparable blood pressures. (portlandpress.com)
  • The rats ate significantly more, and the effect of allopregnanolone was more prominent in the active (dark) compared with the inactive (light) period. (diva-portal.org)
  • We found that, at nanomolar concentrations, vMIP-II effectively attenuated leukocyte infiltration to the kidney and significantly reduced the ensuing renal injury in the treated rats. (rupress.org)
  • Passive avoidance behaviour was significantly affected in mobile phone RF-EMR-exposed rats demonstrated as shorter entrance latency to the dark compartment when compared to the control rats. (buergerwelle.de)
  • Mobile phone RF-EMR exposure significantly altered the passive avoidance behaviour and hippocampal morphology in rats. (buergerwelle.de)
  • Testosterone and 5alpha-dihydrotestosterone significantly increased blood pressure in rats on a low salt diet. (endocrine-abstracts.org)
  • Concomitant application of substrates transported by mrp2 such as bromosulfophthalein (BSP) or the synthetic chlorogenic acid derivative S 3025 significantly reduced the biliary appearance of normal ODN and 2BA-ODN in Wistar rats and also in TR - rats. (ovid.com)
  • Total red blood cell count, haematocrite and haemoglobin concentration was significantly reduced in both male and female rats of groups 5 and 6. (dtu.dk)
  • Relative liver weight was significantly increased in groups 3-6 male and female rats. (dtu.dk)
  • Absolute thymus weight of groups 3-6 male and female rats and relative thymus weight of groups 3-6 male rats and groups 3 and 4 female rats was significantly decreased. (dtu.dk)
  • The results of the present study showed that in spite of resistance training, use of TE in high doses can cause significantly alterations in some of hematologic factors in male rats. (springermedizin.de)
  • Histological type of this carcinoma in all 19 rats was highly differentiated adenocarcinoma, and small intestine epithelium around carcinoma presented atypical epithelium. (osti.gov)
  • Histological type of carcinoma in irradiated rats was highly differentiated adenocarcinoma. (osti.gov)
  • Shivarajashankara YM, Shivashankara AR, Bhat PG, Rao SM, Rao SH (2002) Histological changes in the brain of young fluoride-intoxicated rats. (fluoridealert.org)
  • On days 1and 30 after the end of treatment, 6 ovarectomized rat from each group selected randomly and sections of uterus stained with H&E method were investigated histological and also 4 intact female rat from each group with male rats mate and the number of offspring's of them determined. (sid.ir)
  • The histological effect of oral administration of sildenafil citrate (Viagra), commonly used as an aphrodisiac and for the treatment of erectile dysfunction on one of the visual relay centres namely the lateral geniculate body (LGB) of adult Wistar rat was carefully studied. (cogprints.org)
  • In the major aim of this study is to investigate the effect of Tamoxifen on the histological structure of uterus estrogen, progesterone and LH concentration in the female Wistar rats. (sid.ir)
  • 18-β Glycyrrhetinic acid alleviates 2-acetylaminofluorene-induced hepatotoxicity in Wistar rats: Role in hyperproliferation, inflammation and oxidative stress. (sigmaaldrich.com)
  • This study was designed to investigate the hepatoprotective potential of calcium and magnesium against lead and cadmium induced hepatotoxicity using a rat model. (scialert.net)
  • Kinawy AA (2019) Synergistic oxidative impact of aluminum chloride and sodium fluoride exposure during early stages of brain development in the rat. (fluoridealert.org)
  • McPherson CA, Zhang G, Gilliam R et al (2018) An evaluation of neurotoxicity following fluoride exposure from gestational through adult ages in long-Evans hooded rats. (fluoridealert.org)
  • Perera T, Ranasinghe S, Alles N, Waduge R (2018) Effect of fluoride on major organs with the different time of exposure in rats. (fluoridealert.org)
  • Neuropeptide Y (NPY) reduces ethanol intake under free access conditions in Wistar rats with a history of prolonged ethanol vapor exposure. (diva-portal.org)
  • The current study was designed to determine whether NPY differentially alters ethanol-associated appetitive behavior (i.e., lever pressing) or ethanol consumption in Wistar rats with a history of ethanol vapor exposure. (diva-portal.org)
  • Evaluation of genotoxic effects in male Wistar rats following microwave exposure. (emf-portal.org)
  • To study the effects of microwave exposure on micronuclei formation and antioxidant enzymatic system in adult male rats . (emf-portal.org)
  • 24 rats were divided into two different exposure groups and two different sham exposure groups (each group n=6). (emf-portal.org)
  • Fifty-gigahertz microwave exposure effect of radiations on rat brain. (emf-portal.org)
  • Mutagenic response of 2.45 GHz radiation exposure on rat brain. (emf-portal.org)
  • Is There Any Possible Genotoxic Effect in Exfoliated Bladder Cells of Rat Under the Exposure of 1800 MHz GSM-Like Modulated Radio Frequency Radiation (RFR)? (emf-portal.org)
  • The aim of this study was to determine the haematological changes induced by subchronic glyphosate exposure in Wistar rats and the ameliorative effect of zinc. (scopemed.org)
  • Together, these in vitro data in human and rat skin and in vivo data from rats may be used to predict TBBPA absorption in humans following dermal exposure. (nih.gov)
  • Calvo-Ochoa, E., Hernández-Ortega, K., Ferrera, P., Morimoto, S. and Arias, C. (2014) Short-Term High-Fat-and-Fructose Feeding Produces Insulin Signaling Alterations Accompanied by Neurite and Synaptic Reduction and Astroglial Activation in the Rat Hippocampus. (scirp.org)
  • Marked morphological changes were also observed in the CA(3) region of the hippocampus of the mobile phone-exposed rats in comparison to the control rats. (buergerwelle.de)
  • Therefore, the metabolism of myosmine has been studied in Wistar rats treated with single oral doses of [pyridine-5-3H]myosmine at 0.001, 0.005, 0.5, and 50 micromol/kg body weight. (biomedsearch.com)
  • The rats were tested in the open field prior to the Y-maze and then given voluntary intermittent access to alcohol or water in the home cage for 6 weeks, where after, naltrexone in three different doses or saline was administered in a Latin square design over 4 weeks and alcohol intake and preference was measured. (diva-portal.org)
  • The rats received various doses of RT for 22 weeks. (scialert.net)
  • These doses were found to be non-toxic but not lethal to the treated rats. (nepjol.info)
  • Three groups of rats (200-250gr range) gavaged with doses of 200, 400 and 600ug/kg B.W Tamoxifen dissolved in solvent (ethanol 60% and physiological solution) for 30 days. (sid.ir)
  • A single i.v. injection of streptozotocin alone, 30, 40, 50, or 65 mg/kg of body weight produced adenomas of pancreatic islet cells in 8 of 9 (89%), 6 of 7 (86%), 2 of 4 (50%), and 1 of 2 rats (50%), respectively. (aacrjournals.org)
  • The neoplasms were seen in all of the 8 rats given a single i.p. injection of picolinamide, 250 mg/kg of body weight, 15 min before a single i.v. injection of streptozotocin, 65 mg/kg of body weight. (aacrjournals.org)
  • Among the 14 rats given a single i.p. injection of nicotinamide, 500 mg/kg of body weight, 15 min before a single i.v. injection of streptozotocin, 65 mg/kg of body weight, 13 rats (95%) developed pancreatic islet cell tumors. (aacrjournals.org)
  • Renal tumors were seen in only 3 rats treated with streptozotocin and nicotinamide. (aacrjournals.org)
  • This study demonstrates that streptozotocin, even in a dose of 30 mg/kg of body weight, has an exceedingly marked tumorigenic action on the rat pancreas, while it has little effect on the kidney and no effect on the liver. (aacrjournals.org)
  • At the end of this period diabetes was induced by streptozotocin (STZ) and the rats maintained on the same diets for additional 21 days. (scirp.org)
  • This study in streptozotocin-induced diabetic Wistar rats investigated the anti-hyperglycemic and mitochondrial membrane protection effects of baicalin, a flavonoid known for its radical scavenging activity. (nus.edu.sg)
  • Significant increase in left testis weight and liver weight was observed in male and female rats, respectively. (hindawi.com)
  • Some of the liver drug metabolizing and detoxifying enzymes were depleted under toxic conditions compared with non-toxic rats. (mdpi.com)
  • Therefore, in the present study, 2D monolayer cell culture and 3D spheroid in vitro models, and a rat model, were utilized to investigate the effect of CQ on liver cancer. (spandidos-publications.com)
  • Effect of electromagnetic radiofrequency radiation on the rats' brain, liver and kidney cells measured by comet assay. (emf-portal.org)
  • Rats on control diet had the lowest relative weight for liver (3.74), lungs (1.03), kidney (0.92) and heart (0.49). (ajol.info)
  • A mild degree of centrilobular cell hypertrophy of the liver was seen in all male rats and of three female rats of group 6. (dtu.dk)
  • DH did not change the s(P)RR levels in the renal homogenates and cytosol fraction of these rats. (ahajournals.org)
  • The objective of this study is to investigate the effects of a low-protein diet (LPD) starting from a young age on diabetic status and renal injury in a rat model of type 2 diabetes and obesity. (biomedcentral.com)
  • A study to assess the toxic effects of gamma-hexachlorocyclohexane (γ-HCH) (lindane) and ameliorative effects of Camellia sinensis on renal system has been carried out in male Wistar rats. (veterinaryworld.org)
  • However, supplier-dependent differences and concomitant skew subgroup formations, primarily in open field behavior and intermittent alcohol intake, resulted in a shifted focus to instead study voluntary alcohol intake and preference, and the ensuing response to naltrexone in Wistar rats from three different suppliers. (diva-portal.org)
  • Substantial work has shown that rats although identical in stock, sex, age, and housing conditions can differ considerably in terms of behavior and physiology. (biomedsearch.com)
  • In the open field, HRA rats not only showed more rearing behavior, but also more locomotor activity than LRA rats. (biomedsearch.com)
  • In the plus-maze, HRA rats again showed more locomotion, but did not differ in open arm time or percentage of open arm entries, that is, conventional measures of anxiety-related behavior. (biomedsearch.com)
  • Diazepam (1 h before the tests) reduced anxiety-like behavior in rats forced to swim compared to the vehicle stressed group. (srce.hr)
  • The dose-response curve for diazepam indicated that the 0.5 mg kg-1 dose (1 h before the EPM and OFT) was the minimum effective dose in reducing anxiety-like behavior without altering locomotor activity in weaning rats. (srce.hr)
  • These results indicate that weaning rats can develop anxiety-like behavior after a brief, single session of stress, and that rats at this age are seemingly more sensitive to diazepam than adult rats, which may be taken into account for clinical applications. (srce.hr)
  • Social investigation was impaired in maternally deprived rats only, while saline injection, independently of MD, was associated with increased anxiety-like behavior in the EPM and an impaired intake decrement in the negative sucrose contrast. (frontiersin.org)
  • have reported supplier-dependent differences in alcohol intake, open field and Y-maze behavior, and responsivity to opioid antagonist naltrexone in outbred Wistar rats obtained from three different vendors in Europe. (frontiersin.org)
  • The effects of omega 3 fatty acid supplementation on brain tissue oxidative status in aged wistar rats. (semanticscholar.org)
  • To test these hypotheses, plasma glucose and insulin levels were measured in obese prediabetic Wistar-Fatty rats after two episodes of diet switching, with and without concomitant weight loss. (nih.gov)
  • Together, these results suggest that insulin resistance of Wistar-Fatty rats was worsened by repeated weight fluctuation. (nih.gov)
  • Doze ratos Wistar, machos, foram submetidos à GV e reoperados 30 e 60 dias depois (grupos 30D e 60D) quando um segmento de duodeno foi ressecado para contagem de células de grelina por imunoistoquímica. (scielo.br)
  • No total, 30 ratos Wistar machos foram submetidos à cirurgia para realização de defeitos circulares em ambas as tíbias de cada rato, com radioterapia prévia de 30 dias, sendo que a tíbia direita recebeu a dose de 30Gy e tíbia esquerda a dose de radiação secundária calculada em 7Gy. (scielo.br)
  • Male Wistar rats were fed with two different diets [control (C) and high-cholesterol diet (HC)-containing 2 % cholesterol and 0.5 % cholic acid]. (springer.com)
  • Greenwood, C.E. and Winocur, G. (1996) Cognitive Impairment in Rats Fed High Fat Diets: A Specific Effect of Saturated Fatty-Acid Intake. (scirp.org)
  • To address this important knowledge-gap and to gain insights into the underlying molecular responses in rat to MON810, differential gene expression in the epithelial cells of the small intestine of rats fed formulated diets containing MON810, its near isogenic line, two conventional corn varieties, and a commercial (Purina™) corn-based control diet were investigated using comparative proteomic profiling. (dtu.dk)
  • No adverse clinical or behavioural effects, or biomarkers of adverse health, were observed in rats fed GM corn compared to the other corn diets. (dtu.dk)
  • Initially the animals (newborn male Wistar rats) consumed the diets containing MSG for a period of 70 days. (scirp.org)
  • This text provides a complete account of this particular rat strain. (booktopia.com.au)
  • Overall these findings render RccHan™:WI rats more suitable for studies of individual differences in voluntary alcohol intake and response to naltrexone and further highlight the inherent heterogeneity of the Wistar strain. (diva-portal.org)
  • Wistar rats, an animal strain widely used in the research have been employed to study the effects of dietary interventions due to their metabolic characteristics, which are closer to the human compared to mice. (scirp.org)
  • In contrast to normal Wistar rats, n -ODN excretion into bile by TR - rats, a mutant Wistar rat strain lacking a functional multidrug resistance-associated protein 2 (mrp2) at the canalicular membrane, was strongly diminished, whereas these rats excreted an ODN conjugated with two cholic acid molecules (2BA-ODN) into bile. (ovid.com)
  • Moreover, when compared to the control rats, the animals treated with 5000 mg/kg of the extract exhibited significant reduction in appetite for food and water in the first week. (scirp.org)
  • Prolonged exercise of medium to high intensity is known to promote a substantial effect on the energy balance of rats. (diabetesjournals.org)
  • Finally, both CED and FAD induced a decrease in HDL as compared to control levels in treatments of more than 6 weeks, whereas LDL transiently increased in animals treated with FAD from 10 to 12 weeks, but after this period LDL levels returned to baseline, suggesting that young rats have a compensatory effect at least for the period of time analyzed here. (scirp.org)
  • We conclude that dietary APP has an anti-adipogenic effect in Wistar rats without any anorectic phenomenon. (go.jp)
  • This study was aimed to examine the anticancer effect of resveratrol (RT) against diethylnitrosamine (DEN) induced HCC in Wistar rats. (scialert.net)
  • In this paper, attempts were made to determine the effect of MEin rat stroke model. (magiran.com)
  • To obtain clarity about the actual effect possessed by M. oleifera leaf, an attempt was made in this investigation to study it's antifertility activity in Wistar female rats. (ijpsonline.com)
  • The food intake in rats varies diurnally and that may influence the effect of GABA(A)-receptor active compounds. (diva-portal.org)
  • Therefore, it is easy to envisage that allopregnanolone would have a hyperphagic effect, but earlier reports in rat have given ambiguous results. (diva-portal.org)
  • The aim of this study was to investigate the effect of allopregnanolone on intake of standard chow in male Wistar rats at different time points of the day. (diva-portal.org)
  • It was concluded that extract of L. breviflora exerts toxic effect on the seminiferous tubular epithelium with concomitant reduction in the reproductive potential of the male rats. (academicjournals.org)
  • Paying heed to the importance of physical activity in neural plasticity, this study focuses on the investigation of chronic effect of decreased activity on the form of spinal nerve ligation on NT-4 gene expression of male Wistar rat's sciatic nerve fiber. (magiran.com)
  • We evaluated the effect of RF-EMR from mobile phones on passive avoidance behaviour and hippocampal morphology in rats. (buergerwelle.de)
  • The aim of this study effect of Tamoxifen on the tissue uterus layers and the number of offspring's of females in female Wistar rats were investigated. (sid.ir)
  • Development of the muscular saphenous artery and the effect of surgical denervation on normal development was investigated in young rats at 3 and 6 weeks of age. (ahajournals.org)
  • Davasaztabrizi A, Rakhshiasl A, Mousavi G, Rakhshiasl P (2012) Evaluating the effect of high concentration of testosterone enanthate on some of blood factors in male rat. (springermedizin.de)
  • Swathilatha Rewanthwar and P.K. Lakshmi, "Effect of Piperine, Quercetin, Polysorbate 80 on the Oral Bioavailability of Losartan in Male Wistar Rats", Pharmaceutical Nanotechnology (2014) 2: 49. (eurekaselect.com)
  • 11], amongst others, showed that parenteral (4.0 mg/g b.w.) or oral (2.5 and 5.0 g/day) administration of MSG in newborn rats resulted in an injurious effect on the arcuate nucleus of the hypothalamus. (scirp.org)
  • Effect of sex hormones on plasma phospholipid fatty acid composition in intact rats and rats with bilaterally occluded carotid arteries. (semanticscholar.org)
  • The effects of triclosan on puberty and thyroid hormones in male Wistar rats. (nih.gov)
  • The purpose of this study was to determine effects of triclosan on pubertal development and thyroid hormone concentrations in the male rat. (nih.gov)
  • Beneficial effects of dapsone on ischemia/reperfusion injury following torsion/detorsion in ipsilateral and contralateral testes in rat. (harvard.edu)
  • Based on this claim, the present study investigated the effects of Citrus sinensis (sweet orange) essential oil on Wistar, male rats evaluated in the elevated plus-maze followed by the light/dark paradigm. (nih.gov)
  • Comparing the ionizing radiation effects on bone neoformation of rats tibiae previously submitted to radiotherapy with a single dosage of 30Gy with the contralateral tibiae that have received secondary radiation. (scielo.br)
  • Furthermore, results of the psychotropic test conducted during this study showed visible effects on the exploratory activity of the rats. (scirp.org)
  • Our present study aims to investigate the interaction of melatonin (MEL) with this system by exploring the effects of MEL with or without a facilitator of GABA-ergic neurotransmission, diazepam (DZ) on the levels of depression and anxiety in Wistar rats. (scirp.org)
  • Colonic and systemic effects of extruded whole-grain sorghum consumption in growing Wistar rats. (nextbio.com)
  • As a step in this direction, this study was carried out on effects of aqueous leaf extract of Citrus medica on Neurobehavioral study of the Prefrontal cortex of hyperglycemic Wistar rats. (omicsonline.org)
  • These finding suggest Tamoxifen decreases the fertilization ability and has negative effects on uterus layers and the number of offspring's in female Wistar rats. (sid.ir)
  • 1. The effects of replacing a 1% NaCl drinking solution with Na + -free water for 2 days on body weight and fluid and electrolyte balances were studied in adrenalectomized and sham-operated rats. (clinsci.org)
  • These finding suggest that Tamoxifen decreases the fertilization ability and has negative effects uterus tissue and hormones in female Wistar rats. (sid.ir)
  • Two new quinoxalinone derivatives have been synthesized adopting the HONG method, and investigated for some neuropharmacological effects (anxietyand depressive-like responses) in rats. (scirp.org)
  • We tested the effects of Hoof on female rats. (alliedacademies.org)
  • Radio frequency radiation effects on protein kinase C activity in rats' brain. (emf-portal.org)
  • Effects of electromagnetic field produced by mobile phones on the oxidant and antioxidant status of rats. (emf-portal.org)
  • This study was designed to evaluate the therapeutic potentials and neuroprotective effects of methanol extract of Buchholzia coriacea (BC) seeds on sodium azide (NaN 3 ) induced neurotoxicity of the prefrontal cortex in male Wistar rats. (ajol.info)
  • It was concluded that the LM test presented sensibility to the effects of the training, as well as validity with gold standard test (MLSS) in rats submitted to swimming exercise. (wku.edu)
  • Malgor L, Valsecia M, Verges E et al (1997) Blockade of the in vitro effects of testosterone and erythropoietin on Cfu-E and Bfu-E proliferation by pretreatment of the donor rats with cyproterone and flutamide. (springermedizin.de)
  • We therefore undertook this study to evaluate pharmacodynamics and toxicological profile of oral administration of PartySmart in rats. (redorbit.com)
  • The current study provides direct measurements of leptin and insulin signaling in the hypothalamus and documents increased sensitivity to these hormones in the hypothalamus of exercised rats in an IL-6-dependent manner. (diabetesjournals.org)
  • Our study aimed to reveal the basic differences in blood metabolome (amino acids, biogenic amines, and acylcarnitines) of the adult male ( n = 10) and female ( n = 10) Wistar rats. (mdpi.com)
  • Our study provides an important insight into sex-specific differences in energy metabolism in rats and indicates that further studies should consider sex as the main aspect in design and data interpretation. (mdpi.com)
  • To study this hypothesis, we isolated adrenal glands from control and spontaneously diabetic BB-Wistar rats, perfused them with ACh, and measured catecholamine secretion. (diabetesjournals.org)
  • The objective of this study is to look for preoperative predictors of early T2DM relapse/no remission in patients with obesity and diabetes who underwent Roux ‐en‐Y gastric bypass (RYGB) or loop duodeno‐jejunal bypass with sleeve gastrectomy (LDJB‐SG). (medworm.com)
  • All rats were sacrificed and submitted to excision of pancreas for histopatologic study. (medigraphic.com)
  • In this study, types of fibers constituting male Wistar rats semitendinous and their myosin heavy chains, as well as influence of intermittent training on hypertrophy of these fibers have been checked through MATPase histochemical technique and electrophoretic proteins separation. (scielo.cl)
  • The present study investigated the sensitivity to stress and diazepam in weaning (21-day old) Wistar rats. (srce.hr)
  • None of rats used in this study developed hepatic tumors. (aacrjournals.org)
  • In this study, we exposed 30 laboratory-raised Wistar rats, a suitable model for the infestation, at six different places characterized by different microenvironments in a hyperendemic fishing village in northeastern Brazil. (ajtmh.org)
  • The objective of the present study was to understand the role of fluoride in neurotoxic, neuroinflammatory, and neurodegenerative changes in the brain tissue of Wistar rats. (fluoridealert.org)
  • The present study revealed that Moringa oleifera ethanol extract at dose level 250 and 500 mg/kg produced antifertility activity by inhibiting the implantation in female rats, which required further evaluation for potential contraceptive action. (ijpsonline.com)
  • The objective of the present study was to investigate the antiulcer activity of methanol extract of Oxalis corniculata (whole plant) using pylorus ligation and indomethacin-induced gastric ulceration in Wistar rats. (ijpsonline.com)
  • 100 rats (200-250 weighing) in this of study were used 60 ovarectomized rats and 40 intact female Wistar rats. (sid.ir)
  • The aim of this study was to verify the reproducibility of the lactate minim (LM) test after four weeks of aerobic training, as well as its validity with the maximal lactate steady state (MLSS) in Wistar rats submitted to swimming exercise. (wku.edu)
  • In conclusion, even though our study proves both unilateral left and bilateral hot water vestibular stimulation is beneficial in Scopolamine induced dementic rats in improving spatial cognition as well as motor control, unilateral left vestibular stimulation was found to be more beneficial. (alliedacademies.org)
  • Sixty adult male and female Wistar rats were used for the study. (scopemed.org)
  • Healthy male Wistar rats (weighing 40.0 ± 10.0 g, 21 days), reared in the Animal Facility of the University of Campinas (Unicamp), were used in this study. (scirp.org)
  • Results: Transmission electron microscopy imaging of pancreatic β-cells revealed loss of integrity of the inner membrane of the mitochondria in the diabetic rats, which was not observed in the baicalin-treated group. (nus.edu.sg)
  • We conclude that the limited focal lesion observed in normotensive and sham operated rats is primarily due to surgical trauma of exposing the vessel and passing the ligature deep to it. (ahajournals.org)
  • designated group 1) experienced body weight losses which were outside the 99% confidence limits for the sham-operated rats (- 9.2 to + 5.3 g) whereas the remainder (designated group 2) were indistinguishable from the controls. (clinsci.org)
  • In group 2 rats, fluid balance was maintained as well as in the sham-operated rats, but their handling of Na + and K + was different. (clinsci.org)
  • 4. In a separate experiment, plasma aldosterone, corticosterone, catecholamine and solute concentrations were measured in adrenalectomized rats from groups 1 and 2 (selected on the basis of body weight loss whilst drinking Na + -free water) and sham-operated rats, after drinking Na + -free water for 2 days. (clinsci.org)
  • In group 2, aldosterone was measurable but low, and corticosterone was higher than in group 1 but lower than in sham-operated rats. (clinsci.org)
  • Haematological estimation revealed significant decrease in haemoglobin count in male rats while female rats showed significant increase in granulocyte count. (hindawi.com)
  • Ethanol extract was evaluated at dose levels of 100, 250, 500 mg/kg on fertility, implantation, decidualization and local cytokine signaling during decidualization in female Wistar rats with artificially induced decidualization. (ijpsonline.com)
  • Female Wistar rats, kept under reverse lighting (lights off 11.00-23.00 hr), were sampled during the dark phase at pregnancy days 4, 12 and 18 and lactation days 0, 5, 10 and 25. (open.ac.uk)
  • Incidence of peliosis at approximately 110 weeks of age was higher in female rats. (avmi.net)
  • Ten adult male Wistar rats in the weight range of 250±30 gr were randomly divided into two groups, including one healthy control group (C) and one group with decreased physical activity (SNL). (magiran.com)
  • Twenty Wistar rats were randomly divided into two groups of ten animals: control group and intervention group, treated for 6 weeks with fish oil capsules containing 45 mg eicosapentanoic acid and 30 mg docosahexanoic acid. (semanticscholar.org)
  • Wistar rats of 60 days of life underwent stereotactic surgery and were divided into two groups: control (infusion of saline 0.9%) and hypoxanthine (10 μM). (springer.com)
  • Twelve adult male, Wistar rats underwent SG and were reoperated 30 or 60 days after the initial surgery. (scielo.br)
  • All rats underwent occlusion of pancreatic duct. (medigraphic.com)
  • Aqueous leaf extract of Citrus medica showed ameliorative potentials on the Prefrontal cortex of adult male Wistar rats against the damage initiated by hyperglycemia. (omicsonline.org)
  • After treatment, neurobehavioral assessment was carried out after which the rats were sacrificed, and the prefrontal cortex excised. (ajol.info)
  • 0.05) difference in the mean values of semen volume of rats in the control and test groups. (academicjournals.org)
  • 0.05) decreased the gastric volume, total acidity, free acidity and increase in the pH of the gastric fluid in pylorus-ligated rats. (ijpsonline.com)
  • 0.05) decrease in number of ulcers, ulcers score and ulcer index in pylorus ligated and indomethacin treated rats. (ijpsonline.com)
  • Decrease in body weight and organ development in the deficient animals was noticied and these changes were not seen in the rats that recevived 0.05% tryptophan. (arvojournals.org)
  • 0.05) different from rats on T1, T2, T3, and T5 with rats on T3 having the highest value (3.42). (ajol.info)
  • After 72 hours, rats were killed, and (P)RR protein levels in plasma, urine and kidney were examined by using Western blot. (ahajournals.org)
  • To better understand the role that water and urea fluxes play in the urine concentrating mechanism, we determined transepithelial osmotic water permeability (Pf) and urea permeability (Purea) in isolated perfused Munich-Wistar rat long-loop descending thin limbs (DTLs) and ascending thin limbs (ATLs). (sigmaaldrich.com)
  • On days 3 and 5, 24-h rat urine excretion was collected. (rupress.org)
  • Among the endocrine glands, the highest numbers (types) of spontaneous lesions were observed in adrenal glands followed in descending order by pituitary, thyroid, endocrine pancreas and parathyroid glands in Wistar rats. (avmi.net)
  • In adrenal glands of Wistar rats, the incidences of cortical cell vacuolation, hemorrhages and hemangiectasis/peliosis were increased with age. (avmi.net)
  • Animals: Laboratory bred Wistar rats of either sex were used for the experiments. (redorbit.com)
  • Laboratory rats are the most popular animals in toxicology, neurobehavioral, or cancer research. (mdpi.com)
  • Apomorphine, an unselective dopamine Dl and D2 receptor agonist, induces in laboratory animals (mice and rats), several behavioural phenomena such as stereotyped behaviour, hyperlocomotion, aggressiveness, etc 1-3 . (springer.com)
  • Four groups of rats with 18 each were maintained under standard laboratory hygienic conditions and provided feed and water ad libitum . (veterinaryworld.org)
  • Forty Wistar rats were divided into two groups: control and DP groups. (hindawi.com)
  • These were divided in two groups of five rats each. (medigraphic.com)
  • The rats in group A (Control) were administered with 0.9% physiological saline, while rats in groups B, C, D, and E were administered with the extract of 1000, 2000, 4000 and 8000 mg per Kg body weight, respectively, once daily for 14 days. (academicjournals.org)
  • The rats of both sexes (n=24), average weight of 202g were randomly assigned into three treatment (n=18) and control (n=6) groups. (cogprints.org)
  • The rats in the treatment groups 'A', 'B' and 'C' received respectively, 0.25mg/kg, 0.70mg/kg and 1.43mg/kg body weight of sildenafil citrate base dissolved in distilled water daily for 30 days, through orogastric feeding tube, while that of the control group D, received equal volume of distilled water daily during the period of the experiment. (cogprints.org)
  • They were arranged into eight groups (n=8) such as control, atorvastatin (1 mg/kg), pomegranate (0.5 ml 50%/ rat), atorvastatin and pomegranate, hyper ccholesterolemic group (3% cholesterol diet for 6 weeks before onset of gestation), hypercholesterolemia and atorvastatin and/or pomegranate. (omicsonline.org)
  • Male Wistar-NIN rats of weanling age (21-24 days) of an avg. body weight 35-40g, were randomly assigned into three groups. (arvojournals.org)
  • Twenty young adult male Wistar rats were assigned at random to four groups of five rats each. (thescipub.com)
  • The remaining 48 rats were divided into six groups of four males and four females each. (scopemed.org)
  • Rafecas I. Whole-rat protein content estimation : applicability of the N x 6.25 factor. (harvard.edu)
  • Biochemical studies revealed that there is a decrease in protein content, reduced glutathione (GSH), anti-oxidant enzyme levels and tryptophan-fluorescence in Gr-III rats. (arvojournals.org)
  • Diabetic male Wistar fatty ( fa/fa ) rats (WFRs) were fed a standard diet (23.84% protein) or an LPD (5.77% protein) for 24 weeks beginning at 6 weeks of age. (biomedcentral.com)
  • The aim was to investigate the impact of hypercholesterolemic diet on the metabolome of male Wistar rats by a multiplatform metabolomic fingerprinting. (springer.com)
  • El-Sayyad HI, Amin AH, El-Ghawet HA, El- Shahari EA, El-Gebaly A (2017) Role of Pomegranate Juice and Atorvastatin in Ameliorating Spinal Neurotoxicity of Wistar Rats Maternally Fed on Hypercholesterolemic Diet. (omicsonline.org)
  • Control rats were fed with water. (hindawi.com)
  • Here, we show that intracerebroventricular insulin or leptin infusion reduced food intake in exercised rats to a greater extent than that observed in control animals. (diabetesjournals.org)
  • Catecholamine release in response to perfusion with 20 mM K + was the same in adrenals from diabetic and control rats. (diabetesjournals.org)
  • and rats with only scraping in the diphragm, named G3 (control). (scirp.org)
  • however, fat necrosis and hemorrhage were present only in control group in one rat. (medigraphic.com)
  • In the open field, center exploration was reduced in all maternally-deprived adolescents and in control rats challenged with saline injection. (frontiersin.org)
  • Forty adult male Wistar rats weighing between 160-200 g were randomly grouped into four consisting of ten rats each viz: A. normal control, B. hyperglycemic only, C. hyperglycemic treated with Citrus medica and D. Citrus medica only. (omicsonline.org)
  • Rats on T4 had the highest PCV (47.00%), and neutrophil (25.67%) values, while rat on control had the highest value of RBC 5.95 (×10 6 /mm3). (ajol.info)
  • Hence, the present work was designed to investigate the antiulcer potential of methanol extract of Oxalis corniculata in pylorus ligation and indomethacin-induced rat ulceration model. (ijpsonline.com)
  • You might consider the outbred Sprague Dawley® rat as a substitute. (taconic.com)
  • We have demonstrated previously that spontaneously diabetic BB-Wistar rats exhibit decreased adrenal medullary catecholamine secretion in response to splanchnic nerve terminal stimulation. (diabetesjournals.org)
  • Transepithelial water and urea permeabilities of isolated perfused Munich-Wistar rat inner medullary thin limbs of Henle's loop. (sigmaaldrich.com)
  • Among the proliferative lesions in rats, higher incidences of cortical cell hyperplasia was observed followed by medullary hyperplasia, complex pheochromocytoma, cortical cell adenoma and cortical adenocarcinoma. (avmi.net)
  • Repeated weight fluctuation increases plasma insulin in the obese Wistar fatty diabetic rat. (nih.gov)
  • However, insulin concentrations of weight-cycled rats were 74% higher than those of controls, suggesting an impairment of insulin resistance. (nih.gov)
  • Treatment with insulin or leptin markedly reduced food intake in exercised rats that were pretreated with vehicle, although no increase in sensitivity to leptin- and insulin-induced anorexia after pretreatment with anti-IL-6 antibody was detected. (diabetesjournals.org)
  • Conversely, nondiabetic BB-Wistar rats made diabetic with streptozocin (STZ) and maintained in a hyperglycemic state did not exhibit catecholamine hyposecretion 2 weeks after STZ administration. (diabetesjournals.org)