A strain of Rattus norvegicus with elevated blood pressure used as a model for studying hypertension and stroke.
A strain of Rattus norvegicus used as a normotensive control for the spontaneous hypertensive rats (SHR).
Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.
PRESSURE of the BLOOD on the ARTERIES and other BLOOD VESSELS.
Arteries which arise from the abdominal aorta and distribute to most of the intestines.
A direct-acting vasodilator that is used as an antihypertensive agent.
Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS.
Body organ that filters blood for the secretion of URINE and that regulates ion concentrations.
The nonstriated involuntary muscle tissue of blood vessels.
The number of times the HEART VENTRICLES contract per unit of time, usually per minute.
Precursor of epinephrine that is secreted by the adrenal medulla and is a widespread central and autonomic neurotransmitter. Norepinephrine is the principal transmitter of most postganglionic sympathetic fibers and of the diffuse projection system in the brain arising from the locus ceruleus. It is also found in plants and is used pharmacologically as a sympathomimetic.
An octapeptide that is a potent but labile vasoconstrictor. It is produced from angiotensin I after the removal of two amino acids at the C-terminal by ANGIOTENSIN CONVERTING ENZYME. The amino acid in position 5 varies in different species. To block VASOCONSTRICTION and HYPERTENSION effect of angiotensin II, patients are often treated with ACE INHIBITORS or with ANGIOTENSIN II TYPE 1 RECEPTOR BLOCKERS.
A potent and specific inhibitor of PEPTIDYL-DIPEPTIDASE A. It blocks the conversion of ANGIOTENSIN I to ANGIOTENSIN II, a vasoconstrictor and important regulator of arterial blood pressure. Captopril acts to suppress the RENIN-ANGIOTENSIN SYSTEM and inhibits pressure responses to exogenous angiotensin.
The main trunk of the systemic arteries.
Animals that are produced through selective breeding to eliminate genetic background differences except for a single or few specific loci. They are used to investigate the contribution of genetic background differences to PHENOTYPE.
The physiological narrowing of BLOOD VESSELS by contraction of the VASCULAR SMOOTH MUSCLE.
The 9th cranial nerve. The glossopharyngeal nerve is a mixed motor and sensory nerve; it conveys somatic and autonomic efferents as well as general, special, and visceral afferents. Among the connections are motor fibers to the stylopharyngeus muscle, parasympathetic fibers to the parotid glands, general and taste afferents from the posterior third of the tongue, the nasopharynx, and the palate, and afferents from baroreceptors and CHEMORECEPTOR CELLS of the carotid sinus.
A pyrazine compound inhibiting SODIUM reabsorption through SODIUM CHANNELS in renal EPITHELIAL CELLS. This inhibition creates a negative potential in the luminal membranes of principal cells, located in the distal convoluted tubule and collecting duct. Negative potential reduces secretion of potassium and hydrogen ions. Amiloride is used in conjunction with DIURETICS to spare POTASSIUM loss. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p705)
The ability to detect chemicals through gustatory receptors in the mouth, including those on the TONGUE; the PALATE; the PHARYNX; and the EPIGLOTTIS.
Diseases of the ninth cranial (glossopharyngeal) nerve or its nuclei in the medulla. The nerve may be injured by diseases affecting the lower brain stem, floor of the posterior fossa, jugular foramen, or the nerve's extracranial course. Clinical manifestations include loss of sensation from the pharynx, decreased salivation, and syncope. Glossopharyngeal neuralgia refers to a condition that features recurrent unilateral sharp pain in the tongue, angle of the jaw, external auditory meatus and throat that may be associated with SYNCOPE. Episodes may be triggered by cough, sneeze, swallowing, or pressure on the tragus of the ear. (Adams et al., Principles of Neurology, 6th ed, p1390)
Small sensory organs which contain gustatory receptor cells, basal cells, and supporting cells. Taste buds in humans are found in the epithelia of the tongue, palate, and pharynx. They are innervated by the CHORDA TYMPANI NERVE (a branch of the facial nerve) and the GLOSSOPHARYNGEAL NERVE.
A muscular organ in the mouth that is covered with pink tissue called mucosa, tiny bumps called papillae, and thousands of taste buds. The tongue is anchored to the mouth and is vital for chewing, swallowing, and for speech.
A branch of the facial (7th cranial) nerve which passes through the middle ear and continues through the petrotympanic fissure. The chorda tympani nerve carries taste sensation from the anterior two-thirds of the tongue and conveys parasympathetic efferents to the salivary glands.
Application of principles and practices of engineering science to biomedical research and health care.
The deductive study of shape, quantity, and dependence. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)
Long convoluted tubules in the nephrons. They collect filtrate from blood passing through the KIDNEY GLOMERULUS and process this filtrate into URINE. Each renal tubule consists of a BOWMAN CAPSULE; PROXIMAL KIDNEY TUBULE; LOOP OF HENLE; DISTAL KIDNEY TUBULE; and KIDNEY COLLECTING DUCT leading to the central cavity of the kidney (KIDNEY PELVIS) that connects to the URETER.
Theoretical representations that simulate the behavior or activity of biological processes or diseases. For disease models in living animals, DISEASE MODELS, ANIMAL is available. Biological models include the use of mathematical equations, computers, and other electronic equipment.
In a prokaryotic cell or in the nucleus of a eukaryotic cell, a structure consisting of or containing DNA which carries the genetic information essential to the cell. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)
Any method used for determining the location of and relative distances between genes on a chromosome.
A lysosomal papain-related cysteine proteinase that is expressed in a broad variety of cell types.
Conferences, conventions or formal meetings usually attended by delegates representing a special field of interest.
Discussions, descriptions or catalogs of public displays or items representative of a given subject.
Single or multi-sheet notices made to attract attention to events, activities, causes, goods, or services. They are for display, usually in a public place and are chiefly pictorial.
Societies whose membership is limited to physicians.
A behavior disorder originating in childhood in which the essential features are signs of developmentally inappropriate inattention, impulsivity, and hyperactivity. Although most individuals have symptoms of both inattention and hyperactivity-impulsivity, one or the other pattern may be predominant. The disorder is more frequent in males than females. Onset is in childhood. Symptoms often attenuate during late adolescence although a minority experience the full complement of symptoms into mid-adulthood. (From DSM-V)
Natural analogs of TOCOPHEROLS exhibiting antioxidant activity. These tocol derivatives and isomers contain a benzopyran ring and an unsaturated isoprenoid side chain.
Drugs intended to prevent damage to the brain or spinal cord from ischemia, stroke, convulsions, or trauma. Some must be administered before the event, but others may be effective for some time after. They act by a variety of mechanisms, but often directly or indirectly minimize the damage produced by endogenous excitatory amino acids.
A generic descriptor for all TOCOPHEROLS and TOCOTRIENOLS that exhibit ALPHA-TOCOPHEROL activity. By virtue of the phenolic hydrogen on the 2H-1-benzopyran-6-ol nucleus, these compounds exhibit varying degree of antioxidant activity, depending on the site and number of methyl groups and the type of ISOPRENOIDS.
A collective name for a group of closely related lipids that contain substitutions on the 2H-1-benzopyran-6-ol nucleus and a long hydrocarbon chain of isoprenoid units. They are antioxidants by virtue of the phenolic hydrogen. Tocopherols react with the most reactive form of oxygen and protect unsaturated fatty acids from oxidation.
A natural tocopherol and one of the most potent antioxidant tocopherols. It exhibits antioxidant activity by virtue of the phenolic hydrogen on the 2H-1-benzopyran-6-ol nucleus. It has four methyl groups on the 6-chromanol nucleus. The natural d form of alpha-tocopherol is more active than its synthetic dl-alpha-tocopherol racemic mixture.
Naturally occurring or synthetic substances that inhibit or retard the oxidation of a substance to which it is added. They counteract the harmful and damaging effects of oxidation in animal tissues.
The basic cellular units of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the NERVOUS SYSTEM.
Ruminants of the family Bovidae consisting of Bubalus arnee and Syncerus caffer. This concept is differentiated from BISON, which refers to Bison bison and Bison bonasus.
Sexual intercourse between persons so closely related that they are forbidden by law to marry.
A state in southeastern Australia, the southernmost state. Its capital is Melbourne. It was discovered in 1770 by Captain Cook and first settled by immigrants from Tasmania. In 1851 it was separated from New South Wales as a separate colony. Self-government was introduced in 1851; it became a state in 1901. It was named for Queen Victoria in 1851. (From Webster's New Geographical Dictionary, 1988, p1295 & Room, Brewer's Dictionary of Names, p574)
The mating of plants or non-human animals which are closely related genetically.
Enlargement of the LEFT VENTRICLE of the heart. This increase in ventricular mass is attributed to sustained abnormal pressure or volume loads and is a contributor to cardiovascular morbidity and mortality.
Enlargement of the HEART, usually indicated by a cardiothoracic ratio above 0.50. Heart enlargement may involve the right, the left, or both HEART VENTRICLES or HEART ATRIA. Cardiomegaly is a nonspecific symptom seen in patients with chronic systolic heart failure (HEART FAILURE) or several forms of CARDIOMYOPATHIES.
The state of being deprived of sleep under experimental conditions, due to life events, or from a wide variety of pathophysiologic causes such as medication effect, chronic illness, psychiatric illness, or sleep disorder.
General increase in bulk of a part or organ due to CELL ENLARGEMENT and accumulation of FLUIDS AND SECRETIONS, not due to tumor formation, nor to an increase in the number of cells (HYPERPLASIA).
The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.

Myocardial osteopontin expression coincides with the development of heart failure. (1/3882)

To identify genes that are differentially expressed during the transition from compensated hypertrophy to failure, myocardial mRNA from spontaneously hypertensive rats (SHR) with heart failure (SHR-F) was compared with that from age-matched SHR with compensated hypertrophy (SHR-NF) and normotensive Wistar-Kyoto rats (WKY) by differential display reverse transcriptase-polymerase chain reaction. Characterization of a transcript differentially expressed in SHR-F yielded a cDNA with homology to the extracellular matrix protein osteopontin. Northern analysis showed low levels of osteopontin mRNA in left ventricular myocardium from WKY and SHR-NF but a markedly increased (approximately 10-fold) level in SHR-F. In myocardium from WKY and SHR-NF, in situ hybridization showed only scant osteopontin mRNA, primarily in arteriolar cells. In SHR-F, in situ hybridization revealed abundant expression of osteopontin mRNA, primarily in nonmyocytes in the interstitial and perivascular space. Similar findings for osteopontin protein were observed in the midwall region of myocardium from the SHR-F group. Consistent with the findings in SHR, osteopontin mRNA was minimally increased (approximately 1.9-fold) in left ventricular myocardium from nonfailing aortic-banded rats with pressure-overload hypertrophy but was markedly increased (approximately 8-fold) in banded rats with failure. Treatment with captopril starting before or after the onset of failure in the SHR reduced the increase in left ventricular osteopontin mRNA levels. Thus, osteopontin expression is markedly increased in the heart coincident with the development of heart failure. The source of osteopontin in SHR-F is primarily nonmyocytes, and its induction is inhibited by an angiotensin-converting enzyme inhibitor, suggesting a role for angiotensin II. Given the known biological activities of osteopontin, including cell adhesion and regulation of inducible nitric oxide synthase gene expression, these data suggest that it could play a role in the pathophysiology of heart failure.  (+info)

Genetic and gender influences on sensitivity to focal cerebral ischemia in the stroke-prone spontaneously hypertensive rat. (2/3882)

We have investigated genetic transmission of increased sensitivity to focal cerebral ischemia and the influence of gender in the stroke-prone spontaneously hypertensive rat (SHRSP). Halothane-anesthetized, 3- to 5-month-old male and female Wistar-Kyoto rats (WKY), SHRSP, and the first filial generation rats (F1 crosses 1 and 2) underwent distal (2 mm) permanent middle cerebral artery occlusion (MCAO) by electrocoagulation. Infarct volume was measured by using hematoxylin-eosin-stained sections and image analysis 24 hours after ischemia and expressed as a percentage of the volume of the ipsilateral hemisphere. Infarct volume in males and females grouped together were significantly larger in SHRSP, F1 cross 1 (SHRSP father), and F1 cross 2 (WKY father), at 36.6+/-2.3% (mean+/-SEM, P<0.001, n=15), 25.4+/-2.4% (P<0.01, n=14), and 33. 9+/-1.6% (P<0.001, n=18), respectively, compared with WKY (14+/-2%, n=17). Male F1 cross 1 (18.9+/-2.4%, n=6) developed significantly smaller infarcts than male F1 cross 2 (32.8+/-2%, n=8, P<0.005). Females, which underwent ischemia during metestrus, developed larger infarcts than respective males. A group of females in which the cycle was not controlled for developed significantly smaller infarcts than females in metestrus. Thus, the increased sensitivity to MCAO in SHRSP is retained in both F1 cross 1 and cross 2 hybrids, suggesting a dominant or codominant trait; response to cerebral ischemia appears to be affected by gender and stage in the estrous cycle. In addition, the male progenitor of the cross (ie, SHRSP versus WKY) influences stroke sensitivity in male F1 cohorts.  (+info)

Kidney aminopeptidase A and hypertension, part I: spontaneously hypertensive rats. (3/3882)

Tissue and plasma levels of aminopeptidase A (APA), the principal enzyme that hydrolyzes angiotensin II (Ang II) to angiotensin III, were measured in spontaneously hypertensive rats (SHR) and their normotensive control strain at 3 different ages corresponding to prehypertensive (4 weeks), developing (8 weeks), and established (16 weeks) phases of hypertension. Plasma APA activity was significantly but modestly elevated in SHR at all 3 ages compared with normotensive Wistar-Kyoto rats. Likewise, levels of APA in brain, heart, and adrenal gland were generally, but again only moderately, elevated in SHR at all ages. However, a large increase in APA activity was seen within the kidney in which APA levels were elevated 41%, 51%, and 68% in SHR at 4, 8, and 16 weeks of age, respectively. Kidney APA levels were also significantly increased in immunoblots from 8- and 16-week-old SHR. Glomeruli isolated from 16-week-old SHR had 57% higher APA activity and increased immunoreactivity compared with Wistar-Kyoto rats. To determine whether the increase in kidney APA activity in SHR was related to Ang II levels, SHR were treated for 2 weeks with the angiotensin-converting enzyme inhibitor captopril. Captopril treatment reduced blood pressure to normotensive values and resulted in a 25% reduction in kidney APA activity. These results suggest that APA expression in the kidney may be regulated by activity of the renin-angiotensin system. If so, this would further suggest that upregulation of APA during conditions in which Ang II levels were elevated would have a protective effect against Ang II-mediated cardiovascular diseases, whereas a decrease in APA expression or a failure to upregulate would exacerbate such conditions.  (+info)

PST 2238: A new antihypertensive compound that modulates Na,K-ATPase in genetic hypertension. (4/3882)

A genetic alteration in the adducin genes is associated with hypertension and up-regulation of the expression of renal Na, K-ATPase in Milan-hypertensive (MHS) rats, in which increased ouabain-like factor (OLF) levels are also observed. PST 2238, a new antihypertensive compound that antagonizes the pressor effect of ouabain in vivo and normalizes ouabain-dependent up-regulation of the renal Na-K pump, was evaluated for its ability to lower blood pressure and regulate renal Na,K-ATPase activity in MHS genetic hypertension. In this study, we show that PST 2238, given orally at very low doses (1 and 10 microg/kg for 5-6 weeks), reduced the development of hypertension in MHS rats and normalized the increased renal Na,K-ATPase activity and mRNA levels, whereas it did not affect either blood pressure or Na,K-ATPase in Milan-normotensive (MNS) rats. In addition, a similar antihypertensive effect was observed in adult MHS rats after a short-term treatment. In cultured rat renal cells with increased Na-K pump activity at Vmax due to overexpression of the hypertensive variant of adducin, 5 days of incubation with PST 2238 (10(-10-)-10(-9) M) lowered the pump rate to the level of normal wild-type cells, which in turn were not affected by the drug. In conclusion, PST 2238 is a very potent compound that in MHS rats reduces blood pressure and normalizes Na-K pump alterations caused by a genetic alteration of the cytoskeletal adducin. Because adducin gene mutations have been associated with human essential hypertension, it is suggested that PST 2238 may display greater antihypertensive activity in those patients carrying such a genetic alteration.  (+info)

Angiotensin receptor subtype 1 mediates angiotensin II enhancement of isoproterenol-induced cyclic AMP production in preglomerular microvascular smooth muscle cells. (5/3882)

In a previous study, we found that angiotensin (Ang) II enhances beta-adrenoceptor-induced cAMP production in cultured preglomerular microvascular smooth muscle cells (PMVSMCs) obtained from spontaneously hypertensive rats. The purpose of the present investigation was to identify the Ang receptor subtypes that mediate this effect. In our first study, we compared the ability of Ang II, Ang III, Ang (3-8), and Ang (1-7) to increase cAMP production in isoproterenol (1 microM)-treated PMVSMCs. Each peptide was tested at 0.1, 1, 10, 100, and 1000 nM. Both Ang II and Ang III increased intracellular (EC50s, 1 and 11 nM, respectively) and extracellular (EC50s, 2 and 14 nM, respectively) cAMP levels in a concentration-dependent fashion. In contrast, Ang (3-8) and Ang (1-7) did not enhance either intracellular or extracellular cAMP levels at any concentration tested. In our second study, we examined the ability of L 158809 [a selective Ang receptor subtype 1 (AT1) receptor antagonist] to inhibit Ang II (100 nM) and Ang III (100 nM) enhancement of isoproterenol (1 microM)-induced cAMP production in PMVSMCs. L 158809 (10 nM) abolished or nearly abolished (p <.001) Ang II and Ang III enhancement of isoproterenol-induced intracellular and extracellular cAMP levels. In contrast, PD 123319 (300 nM; a selective AT2 receptor antagonist) did not significantly alter Ang II enhancement of isoproterenol-induced intracellular or extracellular cAMP levels. We conclude that AT1 receptors, but not AT2, Ang (3-8), nor Ang (1-7) receptors mediate Ang II and Ang III enhancement of beta-adrenoceptor-induced cAMP production in cultured PMVSMCs.  (+info)

Role of iNOS in the vasodilator responses induced by L-arginine in the middle cerebral artery from normotensive and hypertensive rats. (6/3882)

1. The substrate of nitric oxide synthase (NOS), L-arginine (L-Arg, 0.01 microM - 1 mM), induced endothelium-independent relaxations in segments of middle cerebral arteries (MCAs) from normotensive Wistar-Kyoto (WKY) and hypertensive rats (SHR) precontracted with prostaglandin F2alpha (PGF2alpha). These relaxations were higher in SHR than WKY arteries. 2. L-N(G)-nitroarginine methyl ester (L-NAME) and 2-amine-5,6-dihydro-6-methyl-4H-1,3-tiazine (AMT), unspecific and inducible NOS (iNOS) inhibitors, respectively, reduced those relaxations, specially in SHR. 3. Four- and seven-hours incubation with dexamethasone reduced the relaxations in MCAs from WKY and SHR, respectively. 4. Polymyxin B and calphostin C, protein kinase C (PKC) inhibitors, reduced the L-Arg-induced relaxation. 5. Lipopolysaccharide (LPS, 7 h incubation) unaltered and inhibited these relaxations in WKY and SHR segments, respectively. LPS antagonized the effect polymyxin B in WKY and potentiated L-Arg-induced relaxations in SHR in the presence of polymyxin B. 6. The contraction induced by PGF2alpha was greater in SHR than WKY arteries. This contraction was potentiated by dexamethasone and polymyxin B although the effect of polymyxin B was higher in SHR segments. LPS reduced that contraction and antagonized dexamethasone- and polymyxin B-induced potentiation, these effects being greater in arteries from SHR. 7. These results suggest that in MCAs: (1) the induction of iNOS participates in the L-Arg relaxation and modulates the contraction to PGF2alpha; (2) that induction is partially mediated by a PKC-dependent mechanism; and (3) the involvement of iNOS in such responses is greater in the hypertensive strain.  (+info)

Training in swimming reduces blood pressure and increases muscle glucose transport activity as well as GLUT4 contents in stroke-prone spontaneously hypertensive rats. (7/3882)

Exercise improves muscle insulin sensitivity and GLUT4 contents. We investigated the beneficial effects of swimming training on insulin sensitivity and genetic hypertension using stroke-prone hypertensive rats (SHRSP). We studied the relationship between genetic hypertension and insulin resistance in SHRSP and Wistar Kyoto rats (WKY) as a control. The systolic blood pressure of SHRSP was significantly reduced by 4-week swimming training (208.4 +/- 6.8 mmHg vs. 187.2 +/- 4.1 mmHg, p < 0.05). The swimming training also resulted in an approximately 20% increase in the insulin-stimulated glucose transport activity (p < 0.05) of soleus muscle strips and an approximately 3-fold increase in the plasma membrane GLUT4 protein expression (p < 0.01) in SHRSP. However, basal and insulin-stimulated glucose transport activity and GLUT4 contents were not significantly different between WKY and SHRSP. There was no difference in insulin resistance in skeletal muscle of SHRSP as compared with WKY. Our results indicated swimming training exercise improved not only hypertension but also muscle insulin sensitivity and GLUT4 protein expression in SHRSP.  (+info)

Maintenance of normal agonist-induced endothelium-dependent relaxation in uraemic and hypertensive resistance vessels. (8/3882)

BACKGROUND: The nitric oxide system has been implicated in several diseases with vascular complications including diabetes mellitus and hypertension. Despite the high prevalence of hypertension and cardiovascular complications in renal failure few studies have examined vascular and endothelial function in uraemia. We therefore chose to study possible abnormalities of the nitric oxide vasodilator system in an animal model of chronic renal failure. METHODS: Adult spontaneous hypertensive rats and Wistar Kyoto rats were subjected to a 5/6 nephrectomy with control animals having sham operations. After 4 weeks blood pressure was recorded and the animals were sacrificed. Branches of the mesenteric arteries were isolated and mounted on a Mulvany myograph. All experiments were performed in the presence of indomethacin (10(-5) M). The vessels were first preconstricted with noradrenaline, exposed to increasing concentrations of acetylcholine (10(-8) to 10(-4) M) and subsequently to sodium nitroprusside (10(-5) M). RESULTS: There was no difference in the relaxation of the four groups of vessels to any of the concentrations of acetylcholine used nor was there any significant difference in the EC50s (control Wistar Kyoto 6.1+/-1.4 x 10(-8) M; uraemic Wistar Kyoto 5.4+/-0.8 x 10(-8) M; control spontaneous hypertensive rats 4.5+/-0.6 x 10(-8) M; uraemic spontaneous hypertensive rats 6+/-0.7 x 10(-8) M). Vasodilatation in response to sodium nitroprusside was unchanged in uraemic vessels. In addition the vascular responses to both acetylcholine and sodium nitroprusside were unaltered in spontaneous hypertensive rats. CONCLUSIONS: We conclude that normal agonist-induced endothelium-dependent relaxation is maintained in experimental uraemia and hypertension.  (+info)

Evidence was found for different outcomes to middle cerebral artery occlusion in the young genetically hypertensive stroke-prone rat (SHRSP) compared to sham operated controls and the Wistar Kyoto rat (WKY). Qualitatively and quantitatively different gross lesions marked by Evans blue-albumin, cortical atrophy, large areas of strikingly altered cortical histology, postoperative survival and motor behavioral deficits differentiate young SHRSP from sham operated controls and the normotensive WKY. We conclude that the limited focal lesion observed in normotensive and sham operated rats is primarily due to surgical trauma of exposing the vessel and passing the ligature deep to it. The grossly larger and qualitatively different lesion in the SHRSP is the result of an inadequate circulation provided by the dorsal cerebral arterial collaterals. Since the 5-6 week old SHRSP were only mildly hypertensive (systolic blood pressure 140 mm Hg), the inadequate collateral circulation appears to be related to ...
In previous studies, we measured a greater intracellular free calcium concentration and net potassium efflux, possibly calcium activated, in lymphocytes from spontaneously hypertensive stroke-prone rats (SHRSP) as compared with Wistar-Kyoto (WKY) rats. In this study, we addressed two related questions: 1) Can the greater intralymphocytic calcium concentration of the SHRSP account for the greater net potassium efflux? 2) Is the calcium sensitivity of calcium-activated potassium channels in lymphocytes from SHRSP different as compared with that of those from WKY rats? Ionomycin, a calcium ionophore, caused a concentration-dependent and proportional increase in net potassium efflux and intracellular free calcium concentration in lymphocytes from both strains of rat. Based on the relations between net potassium efflux and intracellular free calcium concentration established with ionomycin, the resting net potassium efflux of lymphocytes from SHRSP is greater than would be predicted based on the ...
전신성 고혈압에서는 말초혈관의 저항증가로 말초혈관 평활근의 수축력이 증가하는데, 이는 혈관 평활근내 근세망에서 칼슘의 흡수가 증가되기 때문이다. 최근 항고혈압제로 사용되는 nifedipine은 주로 말초혈관 평활근내로의 칼슘흡수를 저해함으로써, 혈관 평활근의 수축력이 감소하고 혈관 이완효과로 인한 혈압하강이 나타난다. 1987년 Rodriguez-Sargent 등에 의한 보고에서는 Dahl-Salt-sensitive Rat(DSR)에서 고혈압과 함께 수정체의 수분과 sodium, potassium의 함량변화로 인한 백내장 발생빈도의 증가가 보고된 바 있다. 이에 연구자는 고혈압의 영향을 연구하는 실험동물인 고혈압성 흰쥐(Spontaneous Hypertensive Rat : 이하 SHR로 약술)를 사용하여, 혈압하강제인 nifedipine 을 투여하여 혈압하강 효과를 검증하고, 수정체의 수분과 양이온(sodium과 potassium)의 변화를 측정 비교하여 ...
TY - JOUR. T1 - Oxotremorine-induced cerebral hyperemia does not predict infarction volume in spontaneously hypertensive or stroke-prone rats. AU - Harukuni, Izumi. AU - Takahashi, Hiroshi. AU - Traystman, Richard J.. AU - Bhardwaj, Anish. AU - Kirsch, Jeffrey R.. PY - 2000. Y1 - 2000. N2 - Objectives: We tested the following hypotheses: a) spontaneously hypertensive stroke-prone rats (SHR-SP) have more brain injury than spontaneously hypertensive rats (SHR) and normotensive controls (Wistar-Kyoto rats [WKY]) when exposed to transient focal ischemia; b) infarction size is not correlated with baseline blood pressure; and c) infarction size is inversely related to the cerebral hyperemic response to oxotremorine, a muscarinic agonist that increases cerebral blood flow (CBF) by stimulating endothelial nitric oxide synthase. Design: In vivo study. Setting: Animal laboratory in a university teaching hospital. Subjects: Adult age-matched male WKY, SHR, and SHR-SP. Interventions: Rats were instrumented ...
BioAssay record AID 332368 submitted by ChEMBL: Vasorelaxation activity in SHR rat assessed as reduction of Bay-K 8644-induced mean arterial blood pressure at 15 mg/kg, iv after 20 mins.
In this study, we evaluate the effect of HO-1 upregulation on blood pressure and cardiac function in the new model of infarct spontaneous hypertensive rats (ISHR). Male spontaneous hypertensive rats (SHR) at 13 weeks (n = 40) and age-matched male Wistar (WT) rats (n = 20) were divided into six groups: WT (sham + normal saline (NS)), WT (sham + Co(III) Protoporphyrin IX Chloride (CoPP)), SHR (myocardial infarction (MI) + NS), SHR (MI + CoPP), SHR (MI + CoPP + Tin Mesoporphyrin IX Dichloride (SnMP)), SHR (sham + NS); CoPP 4.5 mg/kg, SnMP 15 mg/kg, for six weeks, one/week, i.p., n = 10/group. At the sixth week, echocardiography (UCG) and hemodynamics were performed. Then, blood samples and heart tissue were collected. Copp treatment in the SHR (MI + CoPP) group lowered blood pressure, decreased infarcted area, restored cardiac function (left ventricular ejection fraction (LVEF), left ventricular fraction shortening (LVFS), +dp/dtmax, (−dp/dtmax)/left ventricular systolic pressure (LVSP)), inhibited
In experiments vitro on the mitochondria isolated from adult and spontaneous hypertensive rat hearts, we studied the sensitivity of the mitochondrial permeability transition pore (mPTP) opening to its natural inductor, Ca2+. We observed an increase in the sensitivity of mPTP opening to Ca2+ in the heart of spontaneous hypertensive rats because of a decrease in the threshold concentration of this ion required for organ-elles swelling by two orders of magnitude. It was shown that the classical inhibitor mPTP cyclosporin A (10-5 mol / L) partially (54%) inhibited of mPTP opening in the heart of these animals, indicating that the presence in the heart of these animals of cyclosporin A-insensitive component of the mPTP. The results of our observations give reason to conclude that the hypertensive state of the organism is associated with mitochondrial dysfunction, which is characterized, in par-ticular, by an increased sensitivity mPTP to Ca2+, eliciting a widespread tissue damage and diseases of the ...
Salt sensitive hypertension is known to be a contributing factor for the progression of kidney disease. This study was undertaken to investigate the role of excessive dietary salt on renal function and to evaluate the effect of valsartan and amlodipin given as a combination therapy on blood pressure and parameters specific to the renal function in salt loaded SHR rats. 48 male SHR rats at age of 20 weeks and body weight ranging between 270-350 g were used. SHR rats were divided into 3 groups: control group of rats -SHRC (n = 16) given tab water ad libitum and two salt treated groups in which tab water was replaced with a solution of NaCl (1%) from age of 8 weeks given ad libitum: SHRVAL+AMLO group (n = 16) where investigated drugs were administered at a dose of 10 mg/kg/ b.w. (valsartan) and 5 mg/kg/ b.w. (amlodipin) by gavage and SHR NaCl group (n = 16) that received saline in the same volume and the same time intervals as the SHRVAL+AMLO group. For a period of 12 weeks we have investigated the ...
Salt sensitive hypertension is known to be a contributing factor for the progression of kidney disease. This study was undertaken to investigate the role of excessive dietary salt on renal function and to evaluate the effect of valsartan and amlodipin given as a combination therapy on blood pressure and parameters specific to the renal function in salt loaded SHR rats. 48 male SHR rats at age of 20 weeks and body weight ranging between 270-350 g were used. SHR rats were divided into 3 groups: control group of rats -SHRC (n = 16) given tab water ad libitum and two salt treated groups in which tab water was replaced with a solution of NaCl (1%) from age of 8 weeks given ad libitum: SHRVAL+AMLO group (n = 16) where investigated drugs were administered at a dose of 10 mg/kg/ b.w. (valsartan) and 5 mg/kg/ b.w. (amlodipin) by gavage and SHR NaCl group (n = 16) that received saline in the same volume and the same time intervals as the SHRVAL+AMLO group. For a period of 12 weeks we have investigated the ...
Pain is a complex and subjective experience that involves the transduction of noxious stimuli by nociceptive fibers, but also cognitive and emotional aspects [1]. For instance, human studies indicate that pain is perceived as less intense when individuals are distracted from the pain [2]. Gender and genetic differences also influence the pain perception and a number of animal models have been used to study the influence of these factors on nociception [3]. The Spontaneously Hypertensive Rats (SHR) show abnormal nociceptive reactivity in several nociceptive tests [4-8]. In the hot-plate test, SHR are hypoalgesic when compared to rats of other strains [4, 5, 7, 8], but they show normal properties of nociceptive fibers [9]. We have recently reported that hypoalgesia was no longer observed in SHR rats after habituation to the unheated hot-plate apparatus, suggesting that their hypoalgesic phenotype may involve cognitive processes (e.g. distraction) [8]. This is consistent with the fact that SHR have ...
The spontaneously hypertensive rat (SHR) initially bred in Kyoto is the most widely studied animal model of essential hypertension. As controls for the SHR, most workers have used normotensive descendants of Wistar rats from the colony in Kyoto from which the SHR strain was derived (Wistar-Kyoto rats, WKY). But the presumption that WKY are serviceable controls for SHR rests on the tacit assumption that all WKY constitute a single inbred strain. It appears, however, that whereas the National Institutes of Health distributed breeding stocks of SHR after they had been fully inbred (i.e., after 20 generations of brother-sister mating), the breeding stocks of WKY were distributed before they had been fully inbred. Accordingly, the biological variability of WKY may be greater than that of SHR. To investigate this possibility, we obtained SHR and WKY from two of the largest commercial suppliers in the United States and systematically measured the growth rate and blood pressure of these rats under identical
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The numbers of monocytes and macrophages in the walls of cerebral blood vessels were counted on perfusion-fixed frozen brain sections (16 JLffi) of spontaneously hypertensive rats (SHR), stroke-prone SHR (SHR-SP), normotensive Wistar-Kyoto (WKY) rats, and young (16-week-old) and old (2-year-old) normotensive Sprague-Dawley rats (SD-l6w and SD-2y, respectively) using monoclonal antiborlies against rat macrophages (ED2). The staining was visualized with fluoresceinlabeled second antiborlies. The ED2-specific staining in brain sections was restricted to macrophages in a perivascular location. The number of perivascular cells per square millimeter of high-power field was significantly greater in SHR-SP (8.6 ± 2.1; n = 4) and SHR (6. 7 ± 0.9; n = 6) than in normotensive WKY (4.0 ± 0.5; n = 6; p ,0.01). The number of perivascular macrophages was also greater in SD-2y (7.5 ± 2.7; n = 9) than in SD-l6w (2.9 ± 1.8; n = 8; p , 0.01). No ED2 staining was found in the resident microglia or in the ...
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We have demonstrated that the mesenteric arteries of rats with either genetic hypertension or experimental hypertension induced by dexoycorticosterone have similar biochemical alterations which were manifested by (a) increased amount of total wet weight of arteries as well as total protein content of isolated arterial plasma membranes, (b) increased alkaline phosphatase activities in the plasma membranes of arterial smooth muscle, and (c) decreased ATP-dependent transport of calcium by the arterial plasma membranes. The observed abnormal biochemical properties cannot be attributed to the use of different strains of normotensive control rats in the case of genetic hypertension. Deoxycorticosterone treatment alone slightly enhanced alkaline phosphatase activity but did not alter calcium accumulation, weight or protein content of plasma membranes from arterial smooth muscle. The results suggest that abnormal biochemistry of the plasma membrane isolated from small arteries of hypertensive animals, ...
SHR is one of the many distributions that currently work on the Openmoko phones. You can compare a distribution with an Operating System on normal computers. It gives the phone all the software needed for operating. For more information about the different flavors, see distributions. SHR (Stable Hybrid Release) is a community driven distribution based on the FSO framework. SHR can use several different graphical toolkits, for example GTK or EFL. At first, SHR was introduced in order to use the Om 2007.2 GTK software in combination with the new FSO, but things have changed, now SHR comes with a full SHR User Manual in the OpenMoko-Wiki, that supports novice users in their first steps and SHR moves forward to a distribution for every day use. SHR is based on linux kernel and Openembedded ...
O:13:\PanistOpenUrl\:36:{s:10:\\u0000*\u0000openUrl\;N;s:6:\\u0000*\u0000idc\;N;s:6:\\u0000*\u0000fmt\;s:7:\journal\;s:6:\\u0000*\u0000doi\;s:0:\\;s:6:\\u0000*\u0000pii\;s:0:\\;s:7:\\u0000*\u0000pmid\;s:0:\\;s:9:\\u0000*\u0000atitle\;s:119:\ADRENERGIC MECHANISMS DO NOT CONTRIBUTE TO SALT-INDUCED VASOCONSTRICTION IN STROKE-PRONE SPONTANEOUSLY HYPERTENSIVE RAT\;s:9:\\u0000*\u0000jtitle\;s:0:\\;s:9:\\u0000*\u0000stitle\;s:0:\\;s:7:\\u0000*\u0000date\;s:4:\1982\;s:9:\\u0000*\u0000volume\;s:0:\\;s:8:\\u0000*\u0000issue\;s:0:\\;s:8:\\u0000*\u0000spage\;s:0:\\;s:8:\\u0000*\u0000epage\;s:0:\\;s:8:\\u0000*\u0000pages\;s:0:\\;s:7:\\u0000*\u0000issn\;s:0:\\;s:8:\\u0000*\u0000eissn\;s:0:\\;s:9:\\u0000*\u0000aulast\;s:9:\TAKESHITA\;s:10:\\u0000*\u0000aufirst\;s:1:\A\;s:9:\\u0000*\u0000auinit\;N;s:10:\\u0000*\u0000auinitm\;N;s:5:\\u0000*\u0000au\;a:3:{i:0;s:10:\IMAIZUMI T\;i:1;s:10:\ASHIHARA T\;i:2;s:10:\NAKAMURA ...
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SHR # 1057 :: An Anti-Aging Remedy That Costs Nothing Works Immediately And Is Available To Everyone Right Now :: Guest: Brooks Kubik :: When we think
Warts and molluscum contagiosum are caused by an infection with the human papillomavirus (HPV) from skin-to-skin contact or by coming into contact with anything that has been touched by someone with a wart.
We hypothesized that chronic inhibition of NF-κB activity in the hypothalamic paraventricular nucleus (PVN) delays the progression of hypertension and attenuates cardiac hypertrophy by up-regulating anti-inflammatory cytokines, reducing pro-inflammatory cytokines (PICs), attenuating nuclear factor-κB (NF-κB) p65 and NAD(P)H oxidase in the PVN of young spontaneously hypertensive rats (SHR). Young normotensive Wistar-Kyoto (WKY) and SHR rats received bilateral PVN infusions with NF-κB inhibitor pyrrolidine dithiocarbamate (PDTC) or vehicle for 4 weeks. SHR rats had higher mean arterial pressure and cardiac hypertrophy as indicated by increased whole heart weight/body weight ratio, whole heart weight/tibia length ratio, left ventricular weight/tibia length ratio, cardiomyocyte diameters of the left cardiac ventricle, and mRNA expressions of cardiac atrial natriuretic peptide (ANP) and beta-myosin heavy chain (β-MHC). These SHR rats had higher PVN levels of proinflammatory cytokines (PICs), ...
Oxidative stress is a major mediator of cellular injury following ischaemic stroke and reactive oxygen species, like superoxide, have multiple deleterious effects on the components of the neurovascular unit. It is well established that NADPH oxidase is the principal source of superoxide in acute ischaemic stroke and is therefore a target for potential neuroprotective strategies (Moskowitz et al, 2010). Consequently, the second aim of this thesis was to evaluate the potential neuroprotective effect of NADPH oxidase inhibition with low and high dose apocynin following permanent or transient ischaemia. Rats were administered apocynin at a dose of 5mg/kg or 30mg/kg or vehicle, at 5 minutes post-MCAO. Apocynin treatment had no significant effect on infarct volume or functional outcome at 24 hours following permanent MCAO in WKY rats. However, both low and high dose apocynin treatment significantly reduced infarct volume at 72 hours post-MCAO by 60% following 1 hour of ischaemia in Sprague-Dawley ...
The present study examines effects of administration of OKY 046, an inhibitor of thromboxane synthesis, for 100 days on systemic blood pressure and renal function in spontaneously hypertensive rats and in normotensive control rats. Untreated spontaneously hypertensive rats had higher values for thromboxane excretion in the urine and higher values for blood pressure than did normotensive control rats. Administration of OKY 046 decreased systolic and mean arterial blood pressure and urinary excretion of thromboxane and protein in spontaneously hypertensive rats. Administration of OKY 046 decreased thromboxane excretion in the urine of normotensive control rats but had no effect on blood pressure or protein excretion. Renal function, as assessed by the clearances of inulin and p-aminohippuric acid, was greater in spontaneously hypertensive rats treated with OKY 046 than in those receiving vehicle alone. In normotensive control rats, OKY 046 administration did not affect renal function. These ...
TY - JOUR. T1 - Attenuation and recovery of brain stem autoregulation in spontaneously hypertensive rats. AU - Toyoda, Kazunori. AU - Fujii, Kenichiro. AU - Ibayashi, Setsuro. AU - Kitazono, Takanari. AU - Nagao, Tetsuhiko. AU - Takaba, Hitonori. AU - Fujishima, Masatoshi. PY - 1998/3. Y1 - 1998/3. N2 - Cerebral large arteries dilate actively around the lower limits of CBF autoregulation, mediated at least partly by nitric oxide, and maintain CBF during severe hypotension. We tested the hypothesis that this autoregulatory response of large arteries, as well as the response of arterioles, is altered in spontaneously hypertensive rats (SHR) and that the altered response reverts to normal during long-term antihypertensive treatment with cilazapril, an angiotensin-converting enzyme inhibitor. In anesthetized 6- to 7-month-old normotensive Wistar-Kyoto rats (WKY), 4- and 6- to 7-month-old SHR without antihypertensive treatment, and 6- to 7-month-old SHR treated with cilazapril for 10 weeks, local CBF ...
TY - JOUR. T1 - Enhanced vascular reactivity to mastoparan, a g protein activator, in genetically hypertensive rats. AU - Kanagy, Nancy L.. AU - Clinton Webb, R.. PY - 1994/6. Y1 - 1994/6. N2 - Vascular smooth muscle from stroke-prone spontaneously hypertensive rats has an increased responsiveness to the vasoconstrictors angiotensin II and serotonin. This abnormality is postulated to contribute to the hypertension characteristic of this strain of rats. We hypothesized that a portion of the increased responsiveness may be due to altered function of G proteins. This hypothesis was tested using mastoparan, a peptide that mimics ligand-bound receptors to stimulate G proteins directly. In addition, we investigated the mechanism of mastoparan-induced contraction of vascular smooth muscle. Changes in isometric tension were recorded in denuded carotid artery strips from hypertensive and normotensive (Wistar-Kyoto) rats. Vascular strips from the hypertensive rats had a significantly greater response to ...
TY - JOUR. T1 - Intestinal Calcium Transport in Spontaneously Hypertensive Rats (SHR) and Their Genetically Matched WKY Rats. AU - Shibata, Harumichi. AU - Ghishan, Fayez K.. PY - 1990/5. Y1 - 1990/5. N2 - Calcium transport across the basolateral membranes of the enterocyte represents the active step in calcium translocation. This step occurs by two mechanisms, an ATP-dependent pump and a Ca2+/Na+ exchange process. These studies were designed to investigate these two processes in jejunal basolateral membrane vesicles (BLMV) of the spontaneously hypertensive rats (SHR) and their genetically matched controls, Wistar-Kyoto (WKY) rats. The ATP-dependent calcium uptake was stimulated several-fold compared with no ATP condition in both SHR and WKY, but no differences were noted between rate of calcium uptake in SHR and WKY. Kinetics of ATP-dependent calcium uptake at concentrations between 0.01 and 1.0 μM revealed a V max of 0.67 ± 0.03 nmol/mg protein/20 sec and a Km of 0.2 ± 0.03 μM in SHR and V ...
TY - JOUR. T1 - Central cardiovascular action of urotensin II in spontaneously hypertensive rats. AU - Lin, Yingzi. AU - Tsuchihashi, Takuya. AU - Matsumura, Kiyoshi. AU - Fukuhara, Masayo. AU - Ohya, Yusuke. AU - Fujii, Koji. AU - Iida, Mitsuo. PY - 2003/10. Y1 - 2003/10. N2 - We have previously reported that urotensin II acts on the central nervous system to increase blood pressure in normotensive rats. In the present study, we have determined the central cardiovascular action of urotensin II in spontaneously hypertensive rats (SHR). Intracerebroventricular (ICV) injection of urotensin II elicited a dose-dependent increase in blood pressure in both SHR and normotensive Wistar-Kyoto rats (WKY). The changes in mean arterial pressure induced by ICV urotensin II at doses of 1 and 10 nmol in the WKY were 8±2 and 23±3mmHg, respectively. ICV administration of urotensin II caused significantly greater, increases in blood pressure in SHR (16±3 mmHg at 1 nmol and 35±3 mmHg at 10 nmol, respectively) ...
1 the alpha(2)-adrenoceptor function in mesenteric arteries of spontaneously hypertensive rats (SHR) was investigated by comparing membrane potential changes in response to adrenergic agonists in preparations from female SHR, Wistar-Kyoto (WKY) and normotensive Wistar rats (NWR).2 Resting membrane potential was found to be less negative in mesenteric arteries from SHR than in those from NWR and WKY. Apamin induced a decrease in the membrane potential of mesenteric artery rings without endothelium from NWR and WKY, but had no effects in those from SHR. Both UK 14,304 and adrenaline, in the presence of prazosin, induced a hyperpolarization that was significantly lower in de-endothelialized mesenteric rings from SHR than in those from NWR and WKY. in mesenteric rings with endothelium, however, similar hyperpolarization was observed in the three strains.3 in NWR mesenteric rings with endothelium the hyperpolarization induced by activation of alpha(2)-adrenoceptors was abolished by apamin, whereas in ...
TY - JOUR. T1 - Regenerative electrical activity and arterial contraction in hypertensive rats. AU - Lamb, Fred S.. AU - Webb, R Clinton. PY - 1989/1/1. Y1 - 1989/1/1. N2 - Isolated tail arteries from spontaneously hypertensive rats-stroke prone strain (SHRSP) display oscillatory contractile responses to norepinephrine. These oscillations are not observed in tail arteries from normotensive Wistar-Kyoto rats (WKY). The mechanism underlying these oscillatory contractions was investigated by simultaneous measurement of isometric force development and membrane potential (Em) from tail artery strips in vitro. After equilibration in physiological salt solution containing 1.6 mM calcium (37° C), resting Em was not different between WKY (−52±1.1 mV) and SHRSP (−52±0.4 mV). Norepinephrine (3×10−7 M) produced a similar degree of depolarization in tissues from the two strains (WKY=−42.5±0.9, SHRSP=−41±0.8). However, while Em recordings from WKY arteries were quiescent, those from SHRSP ...
Experimental evidence indicates that hypertension is a multifactorial disorder and that the products of several genes may contribute to its development. The aim of this study was to investigate the expression of hypertension-related genes in spontaneous hypertensive rats (SHRs). A microarray screeni …
TY - JOUR. T1 - Reductions in blood pressure after acute exercise by hypertensive rats. AU - Overton, J. M.. AU - Joyner, M. J.. AU - Tipton, C. M.. PY - 1988. Y1 - 1988. N2 - Postexercise reductions in blood pressure at rest have been reported for hypertensive subjects. To determine whether postexercise hypotension would occur in spontaneously hypertensive rats and to test the hypothesis that any reductions would result because of decreases in regional vascular resistances, hypertensive rats (n=19) were instrumented with indwelling arterial catheters and Doppler probes to measure regional blood flows from the iliac, superior mesenteric, and renal arteries. Data were collected from animals who performed a 20- and a 40-min treadmill test at between 60 and 70% of their maximum O2 uptake. When the animals ran for 20 min, there was a pre- to postexercise drop in mean arterial pressure (MAP) from 158±3.6 to 150±3.6 mmHg (P,0.05) which was recorded 30 min after the exercise had ceased. The pre- to ...
Placentas from spontaneously hypertensive rats (SHR) were compared to those of control strain Wistar-Kyoto rats (WKY) at 15, 18 and 20 days of gestation using light microscopic techniques. Placental lesions similar to those in pregnant hypertensive women were absent in both strains; however, other abnormalities were noted. Hemorrhage at the lateral edges of the decidua basalis appeared to be more extensive in the SHR than WKY at 15 days. At the same time, bloody vaginal discharges were noted in 18% of the SHR. Leukocytic encapsulation of 20-day placentas with viable fetuses was noted in two SHR dams but not in any WKY. It is thought that these differences may be related to the high maternal blood pressure in the SHR or to hormonal imbalance associated with the stress response in the SHR due to frequent monitoring of blood pressure.
PURPOSE: To evaluate the effects of L-arginine oral supplementation in spontaneously hypertensive pregnant rats (SHR). METHODS: Thirty SHR and ten Wistar-EPM-1 virgin female rats were used in the study. Before randomization, females were caged with males of the same strain (3:1). Pregnancy was confirmed by sperm-positive vaginal smear (Day 0). Wistar-EPM-1 rats served as counterpart control (C-1). SHR rats were randomized in 4 groups (n=10): Group Control 2, non-treated rats; Group L-Arginine treated with L-arginine 2%; Group Alpha-methyldopa treated with Alpha-methyldopa 33mg/Kg; Group L-Arginine+Alpha-methyldopa treated with L-arginine 2%+Alpha-methyldopa 33mg/Kg. L-arginine 2% solution was offered ad libitum in drinking water and Alpha-methyldopa was administered by gavage twice a day during the length of pregnancy (20 days). Blood pressure was measured by tailcuff plethysmography on days 0 and 20. Body weight was measured on days 0, 10 and 20. Results were expressed as mean ± SD (Standard ...
Thoracic aortas (TA) were excised from 6-week old SHR and WKY. 2mm rings were mounted isometrically at optimum preload. Spontaneous rhythmical activity developed in TA from SHR and had a frequency of 3-4/min with varying periods of quiescence between bursts of activity. The spontaneous activity often produced an increase in tension development which was associated with increased frequency of oscillations. Verapamil (10/sup -7/ M) or Ca/sup + +/-free solution added during the contractile phase resulted in an immediate loss of tension and spontaneous activity. Addition of ouabain (10/sup -4/ M) during the contractile phase of spontaneous activity, increased the frequency of oscillations which appeared to fuse into a tetanus. Spontaneous rhythmical activity was infrequently observed in TA from WKY. However, addition of phorbol 12-myristate-13 acetate (TPA), frequently induced spontaneous rhythmic oscillations associated with tension development in TA from WKY. TPA contracted the SHR TA and ...
EN] The aim of this study is to investigate the effects of the different selenium (Se) intake on oxidative status and their impact on the lipid profile and the state of the vessel wall in normotensive Wistar-Kyoto rats ...
hypertensive changes in the eye, hypertensive changes in kidney, hypertensive changes in ecg, hypertensive changes on fundoscopy, hypertensive changes in heart, hypertensive changes in brain, hypertensive changes in kidney histology
The elevated blood pressure of spontaneously hypertensive rats (SHR) was further exacerbated by subjecting these animals to surgically induced adrenal-regeneration hypertension (ARH). When chronic abnormally high blood pressure had been in effect for
S.B. Harrap, A.E. Doyle; Genetic Correlation of Renal Hemodynamics and Blood Pressure in the Spontaneously Hypertensive Rat. Clin Sci (Lond) 1 January 1987; 72 (s16): 21P. doi: https://doi.org/10.1042/cs072021P. Download citation file:. ...
Spontaneously hypertensive rats (SHR) and Wistar Kyoto rats (WKY) were distributed into 2 groups: sedentary (SHRsd and WKYsd, n=10 each) and swimming-trained (SHRtr, n=10 and WKYtr, n=10, respectively). The trained group participated in training sessions 5 days/week for 1 h/day with an additional work load of 4% of the animals body weight. After a 10-week sedentary or aerobic training period, the rats were euthanized. The thoracic aortas were removed to evaluate the vasodilator response to acetylcholine (10-10 to 10-4 M) with or without preincubation with L-NG-nitro-L-arginine methyl ester hydrochloride (L-NAME; 10-4 M ...
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The reduced pO2 in outer and inner cortex, and inefficient utilization of O2 for Na+ transport in the SHR kidney can be ascribed to the effects of AT1-R, largely independent of blood pressure.
Semantic Scholar extracted view of Increased sensitivity to endothelin-1 in spontaneously hypertensive rats is closely related to resting membrane potential by Tomohisa Ishikawa et al.
Response of AA-resistant Wistar Kyoto (WKY) rats to Bhsp65 peptides after injection of M. tuberculosis. Rats were immunized with M. tuberculosis subcutaneousl
SHR # 1386 :: The BluePrint Power Hour PLUS Reversing Arthritis And Pain Naturally :: Guest: Rob Regish - Gary Null :: Regish answers listener
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This study shows that adult hypertensive SHR exhibit higher cNOS activity in the heart than normotensive WKY rats. In contrast, in young SHR, in which high blood pressure is not yet established, cNOS activity was similar to that in young and adult WKY rats. These findings indicate that increased cNOS activity in the heart is related to hypertension and not to differences in age or strain. The left and right ventricles hold the highest differential pressure in the cardiovascular system18 ; this difference is higher in hypertension.18 19 The cNOS activity, selectively assessed in both sides of the heart, indicated that in hypertensive animals the left side has higher enzyme activity than the right side. In normotensive rats, on the other hand, the activities of the enzyme were similar in both sides of the heart. Whole hearts of adult WKY rats showed no enhanced cNOS activity compared with those of young rats, while blood pressure was significantly higher. These observations suggest that within the ...
TY - JOUR. T1 - Antihypertensive action of allantoin in animals. AU - Chen, Mei Fen. AU - Tsai, Jo Ting. AU - Chen, Li Jen. AU - Wu, Tung Pi. AU - Yang, Jia Jang. AU - Yin, Li Te. AU - Yang, Yu Lin. AU - Chiang, Tai An. AU - Lu, Han Lin. AU - Wu, Ming Chang. PY - 2014. Y1 - 2014. N2 - The agonists of imidazoline I-1 receptors (I-1R) are widely used to lower blood pressure. It has been indicated that guanidinium derivatives show an ability to activate imidazoline receptors. Also, allantoin has a chemical stricture similar to guanidinium derivatives. Thus, it is of special interest to characterize the effect of allantoin on I-1R. In conscious male spontaneous hypertensive rats (SHRs), mean blood pressure (MBP) was recorded using the tail-cuff method. Furthermore, the hemodynamic analyses in catheterized rats were applied to measure the actions of allantoin in vivo. Allantoin decreased blood pressures in SHRs at 30 minutes, as the most effective time. Also, this antihypertensive action was shown in ...
To define the mechanism for the hypercalciuria in spontaneously hypertensive rats (SHR), Ca clearance was evaluated in fasted 23-wk-old SHR and normotensive Wistar Kyoto (WKy) controls. There was no exaggerated calciuria before or after parathyroidectomy. Ca balance was therefore measured in the nonfasted animals, which revealed hyperabsorption in SHR of both sexes with increments 10-fold that of Ca excretion, supporting the primacy of intestinal hyperabsorption. In situ duodenal Ca uptake was also increased in the SHR. Parathyroidectomy did not affect the hyperabsorption. Hypercalcemia (total and ionized) and hypercalciuria in SHR associated with reduced adenosine 3,5-cyclic monophosphate excretion, were abolished by fasting. Correction of hypertension for 6 mo failed to abolish the hypercalciuria. Bone Ca deposits were increased in 1-yr-old SHR. Ten-week-old SHR, in contrast, displayed mild malabsorption. Our data do not support the renal leak hypothesis. Instead, the adult SHR is ...
Previous findings have shown that hypotensive doses of losartan prevent the excess of apoptosis present in the hypertrophied left ventricle of adult spontaneously hypertensive rats (SHR). This study was designed to determine whether angiotensin II facilitates apoptosis in cardiomyocytes of adult SHR.. Primary cultures of ventricular cardiomyocytes from 30-week-old normotensive Wistar-Kyoto rats (WKY) and SHR with left ventricular hypertrophy were exposed to 10(-)(9) mol/L angiotensin II for 24 hours. Apoptotic cells were assessed by terminal deoxynucleotidyl transferase assay and confirmed by Annexin V detection. The expression of Bax-alpha, Bcl-2, p53, and caspase-3 proteins was assessed by Western blot assays. The expression of BAX gene was assessed by Northern blot. Angiotensin II increased (P,0.01) cardiomyocyte apoptosis, and this effect was higher (P,0.001) in SHR cells than in WKY cells.. Whereas losartan (10(-7) mol/L) blocked the apoptotic effect of the octapeptide in cells from the two ...
1. Plasma volume, packed cell volume (PCV), blood volume, extracellular fluid volume (ECFV) and Evans blue disappearance rate were measured in conscious spontaneously hypertensive rats and in weight-matched Wistar normotensive rats.. 2. Over the weight range studied (250-350 g), plasma and blood volumes were significantly lower in the spontaneously hypertensive rat. Extracellular fluid volumes were similar in the two groups. PCV arid Evans blue disappearance rates were significantly higher in the spontaneously hypertensive rat.. 3. Negative correlations were obtained between plasma volume and mean arterial pressure and between the plasma/interstitial fluid volume ratio and mean arterial pressure.. 4. the normal extracellular fluid volume and the lack of correlation with mean arterial pressure excludes volume expansion as a pressor mechanism during the established phase of hypertension in the spontaneously hypertensive rat.. ...
The purpose of our study was to determine whether Gi-mediated control over adenylyl cyclase in preglomerular arteriolar smooth muscle cells (PGASMC) is enhanced in the spontaneously hypertensive rat (SHR). PGASMC were cultured from preglomerular microvessels isolated from adult SHR (14-15 wk of age) and age-matched WKY rats. Confluent monolayers of cells in third passage were used for the experiments. cAMP released into the media (30 min) as well as cellular levels of cAMP were measured in the presence of a phosphodiesterase inhibitor, 1-isobutyl-3-methyl-xanthine (IBMX; 100 μM) and expressed as pmol/mg protein. Total (released + cellular) cAMP was significantly lower in SHR (14.19 ± 2.30 pmol/mg protein) as compared with WKY (28.3 ± 3.04 pmol/mg protein). Correspondingly, the released (4.6 ± 0.4 pmol/mg protein) as well as cellular (9.78 ± 2.18 pmol/mg protein) cAMP levels were also significantly lower in SHR when compared with WKY (8.85 ± 1.26 and 18.86 ± 2.0 pmol/mg protein, ...
We have previously reported that casein hydrolysate, CH-3, from bovine milk and casein-derived tripeptide Met-Lys-Pro (MKP) has ACE inhibitory activity and reduces blood pressure. In this study, we investigated the therapeutic effects of MKP in a hypertensive rat model (7-week-old male SHRSP/Izm rats). For long term evaluation, rats were fed either a diet containing CH-3 or normal diet. The survival rate of SHRSP rats was significantly improved by intake of CH-3 for 181 days. For short term evaluation, rats were orally administered synthetic tripeptide MKP or distilled water for 4 weeks. MRI study demonstrated that hemorrhagic lesions were observed in two of five rats in the control group, while no hemorrhagic lesions were observed in the MKP group. Volumetric analysis using MRI revealed that MKP administration inhibited atrophy of diencephalic regions. Histological examinations revealed that hemorrhage areas and astrogliosis in the hippocampus and cerebral cortex were lower in the MKP group than in the
BHT - Borderline Hypertensive. Looking for abbreviations of BHT? It is Borderline Hypertensive. Borderline Hypertensive listed as BHT
To assess the effect of angiotensin II type 1 (AT1) receptor antagonist losartan on myocardium connexin43 (Cx43) gap junction (GJ) expression in spontaneously hypertensive rats (SHRs) and investigate possible mechanisms. Sixteen 9-week-old male SHRs and 8 age-matched male Wistar-Kyoto (WKY) rats...
BACKGROUND: Nitric oxide (NO) deficiency occurs in humans and animals with hypertension and chronic kidney disease (CKD). An inhibitor of NO synthase, N(G)-nitro-l-arginine methyl ester (L-NAME) exacerbates kidney damage in the adult spontaneously hypertensive rat (SHR). We examined whether L-NAME exacerbated hypertensive nephrosclerosis in young SHRs and whether melatonin protects SHRs against kidney damage by restoration of the asymmetric dimethylarginine (ADMA)-NO pathway.. METHODS: Rats aged 4 weeks were randomly assigned into three groups (n = 10 for each group): Group 1 (control), SHRs without treatment; Group 2 (L-NAME), SHRs received L-NAME (80 mg/L) in drinking water; and Group 3 (L-NAME + melatonin), SHRs received L-NAME (80 mg/L) and 0.01% melatonin in drinking water. All rats were sacrificed at 10 weeks of age.. RESULTS: L-NAME exacerbates the elevation of blood pressure, renal dysfunction, and glomerular sclerosis in young SHRs. L-NAME induced an increase of ADMA and a decrease of ...
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Histogram distributions of impulsive, inattentive and hyperactive behavior in 16 Spontaneously Hypertensive Rats (SHR) and 15 control Wistar-Kyoto (WKY) rats.
The purpose of the present study was to compare influence of central arginine vasopressin (AVP) and of atrial natriuretic peptide (ANP) on control of arterial blood pressure (MAP) and heart rate (HR) in normotensive (WKY) and spontaneously hypertensi
BACKGROUND AND OBJECTIVES: Dysregulation of histone deacetylase expression and enzymatic activity is associated with a number of diseases. It has been reported that protein levels of histone deacetylase (HDAC)1 and HDAC5 increase during human pulmonary hypertension, and that the enzymatic activity of HDAC6 is induced in a chronic hypertensive animal model. This study investigated the protein expression profiles of class I and II a/b HDACs in three systemic hypertension models. SUBJECTS AND METHODS: We used three different hypertensive animal models: (i) Wistar-Kyoto rats (n=8) and spontaneously hypertensive rats (SHR; n=8), (ii) mice infused with saline or angiotensin II to induce hypertension, via osmotic mini-pump for 2 weeks, and (iii) mice that were allowed to drink L-N(G)-nitro-L-arginine methyl ester (L-NAME) to induce hypertension ...
A series of 1, 4-dihydro-2, 6-dimethyl-4-{4-[3-(2-aminopyrazine/1-amino-4-methyl piperazine)-2-hydroxy propoxy]-phenyl}-pyridine-3, 5-carbamoyl have been synthesized and the structure of the compounds have been confirmed by IR, ¹H NMR , MS & elemental analysis. The title compounds have been evaluated for antihypertensive activity by tail-cuff method. Some of these compounds have been found to exhibit excellent antihypertensive activity ...
Di Nicolantonio, Robert, Dusting, GJ, Hutchinson, JS and Mendelsohn, FAO 1981, Aspirin does not modify the hypotensive action of captopril in spontaneously hypertensive rats, Clinical and Experimental Pharmacology and Physiology, vol. 8, no. 4, pp. 406-406. ...
Fingerprint Dive into the research topics of Hormonal and hemodynamic responses to halothane and enflurane in spontaneously hypertensive rats. Together they form a unique fingerprint. ...
The aim of the studies described in this thesis was to investigate the development of experimental hereditary hypertension and to persistently ameliorate the development of hypertension due brief interventions during early development (perinatal treatment). We used two different models of experimental hereditary hypertension, namely the spontaneously hypertensive rat (SHR) and ... read more the fawn-hooded hypertensive rat (FHH). SHR and FHH dams and their offspring were supplemented with five different treatments during pregnancy and lactation. We found that in both models the perinatal manipulation on the balance between nitric oxide (NO) and reactive oxygen species, with L-arginine and antioxidants, resulted in a persistent decrease in blood pressure and prevented renal injury in the FHH. A similar effect was found after perinatal inhibition of the inflammatory transcription factor NF-kappaB. With micoarray analysis we investigated the transcriptome throughout life in SHR and we developed a ...
1. A method is described for the preparation of renal extracts which are capable of reducing the blood pressure of rats with experimental hypertension. A total dose of 58 grams equivalent of fresh hog kidney, injected intramuscularly twice daily for a period of four days, was found to produce a pronounced and prolonged lowering of the blood pressure.. 2. Oral administration of similar renal extracts at comparatively high doses failed to produce a comparable effect on the blood pressure.. 3. Extracts of beef liver and muscle prepared according to the same procedure as employed for renal extracts, failed to lower the blood pressure in hypertensive rats.. 4. The failure of hog renin to produce a lowering of blood pressure in hypertensive rats in our routine four day test seems to militate against the interpretation that the anti-pressor effect of renal extracts might be due to the formation of an anti-renin substance.. ...
Later we showed that SHR protein is able to move from the stele, where it is synthesized to the adjacent cells including the QC, CEI, CEID and the endodermal lineage. Several TFs had been documented to move, but SHR was the first case in which there was a clear developmental consequence of movement. What was striking in the case of SHR movement was that it was tightly regulated. We found that SHR interacts with SCR in the endodermis (and in the CEI, CEID and QC) and SCR sequesters SHR in the nucleus. Moreover, SHR and SCR together bind to the SCR promoter to activate its transcription. Thus, a positive feedback loop is formed that rapidly increases SCR protein levels ensuring a tight control over SHR movement. The SHR-SCR complex directly regulates the cell cycle through activation of CYCLIN D6 (CYCD6). Another cell cycle factor, RETINOBLASTOMA-RELATED (RBR) binds SCR and inhibits SHR-SCR activity. RBR activity in turn can be inhibited by CYCD6. In addition, a family of C2H2 zinc finger TFs are ...
Hypertension, mRNA, Polymerase Chain Reaction, Rat, Rats, Reverse Transcription, Spontaneously Hypertensive Rats, Time, Wky Rats, Adrenoceptors, Aging, Animal, Animal Models, Arteries, Artery, Bladder, Blood, Blood Pressure, Fischer Rats, Iliac Artery
The search of the terms Kyoto has generated 168 results in the photo collection.Photo: Kyoto Nanzenji pine. Category: Kyoto. Description:Travel view of Kyoto featuring Nanzenji pine. The image location is Japan in Asia.
Atridia, a subsidiary of Jiangsu Hengrui Medicine is developing SHR 1316, a humanised immunoglobulin G4 (IgG4) monoclonal antibody that binds specifically to
Furedi N, Miko A, Aubrecht B, Gaszner B, Feller D, Rostas I, Tenk J, Soos S, Balasko M, Balogh A, Pap M, Petervari E: Regulatory Alterations of Energy Homeostasis in Spontaneously Hypertensive Rats (SHR)., JOURNAL OF MOLECULAR NEUROSCIENCE 59: (4) pp. 521-530 ...
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... rats, inbred oletf MeSH B01.050.157.760.300 - rats, inbred shr MeSH B01.050.157.760.360 - rats, inbred wf MeSH B01.050.157.760. ... rats, inbred oletf MeSH B01.050.199.520.760.300 - rats, inbred shr MeSH B01.050.199.520.760.360 - rats, inbred wf MeSH B01.050. ... rats, inbred aci MeSH B01.050.157.760.090 - rats, inbred bb MeSH B01.050.157.760.110 - rats, inbred bn MeSH B01.050.157.760.130 ... rats, inbred f344 MeSH B01.050.157.760.275 - rats, inbred lec MeSH B01.050.157.760.280 - rats, inbred lew MeSH B01.050.157.760. ...
1975 - Began offering the SHR hypertensive rat and the WKY control strain. 1980 - Taconic developed the first Isolated Barrier ... 1994 - Contracted with National Institute for Allergy and Infectious Disease to maintain a repository of inbred, congenic, and ... 1969 - Began offering rats, including Sprague Dawley, one of the most popular breeds of laboratory rat 1969 - Taconic was the ... 1982 - Began offering Fischer 344 rats and asthmatic rats from Merck-Frost, Montreal, to the product offerings. 1985 - ...
The north shore, steeply sloped, has some moderate hills, with Killiechronan Wood to the east. The southern shore consists of ... As the comic novel takes the perils of island inbreeding as its theme, it is assumed that Tranter deliberately chose an ... but he and his family were forced out by a plague of rats. Staffa (Scottish Gaelic: Stafa, pronounced [s̪t̪afa]) lies about 10 ... before looping back to head to Tobermory via the north shore of Mull. The B8035 road runs along Loch na Keal's southern shore, ...
Another takahē was caught by another dog, also on the shore of Lake Te Anau, on 7 August 1898; the dog, named 'Rough', was ... This may lead to reduced population growth rates and increased rates of inbreeding over time, thereby posing problems regarding ... Secondly, they suggested that Polynesian settlers arriving about 800-1,000 years ago, bringing dogs and Polynesian rats and ... GRUEBER, CATHERINE E.; LAWS, REBECCA J.; NAKAGAWA, SHINICHI; JAMIESON, IAN G. (11 November 2010). "Inbreeding Depression ...
There is also one confirmed site, since cleared, along Brígida Creek on the north shore of Rio São Francisco in Pernambuco. The ... It is suspected that late maturity in captivity may be due to inbreeding or other artificial environmental factors, as other ... Contributing factors were the anthropic introduction of invasive and predatory species of black rats, feral cats, mongooses and ... Other recent evidence has shown that anthropic changes that occurred on the northern shore of the São Francisco River, such as ...
Rats, which this species eat, have been poisoned by farmers, so were also a cause for the diminishing of the species. The ... from Pengze to the western shore of Lake Tai (Tai Hu), the mountainous regions of southern Anhui, and the provinces of Jiangsu ... A compensation mechanism of the Chinese alligator for inbreeding". Animal Reproduction Science. 187: 124-132. doi:10.1016/j. ...
... but decides at the last minute to rat on Eduardo. This leads to the other inmates in the jail to think Luther is the rat and it ... Their clan is built entirely from inbreeding and Liam and Ryan have an incestuous relationship with each other and their deaf- ... She spent a night with Charlie at the Jersey Shore while she was high on ecstasy; in the morning she was sickened and left, but ... They appear in "Charlie Kelly: King Of The Rats" where Frank wants the gang to invite them to go to the gang's luau. They later ...
He auditioned for the role while he had a recurring role as Tommy Ravetto on North Shore. Michael Scofield (played by Wentworth ... Though Bagwell initially believed himself to be incapable of fathering a child due to being conceived as a result of inbreeding ... is imprisoned at Fox River State Penitentiary for aggravated robbery and was ratted out by the man trying to steal his ...
The Yangtze was flooded in the winter of 1957, which is believed to have caused many Chinese alligators to drown.[36] Rats, ... A compensation mechanism of the Chinese alligator for inbreeding". Animal Reproduction Science. 187: 124-132. doi:10.1016/j. ... from Pengze to the western shore of Lake Tai (Tai Hu), the mountainous regions of southern Anhui, and the provinces of Jiangsu ...
Embryo viability was significantly reduced in inbred exposed fish and there was a tendency for inbred males to sire fewer ... The stem cells successfully migrated into diseased rats' retinas, and took on the characteristics of the surrounding neurons. ... which reduces the depth of the pool to simulate the shore of a river. Zebrafish spawn best in the morning due to their ... When close relatives mate, progeny may exhibit the detrimental effects of inbreeding depression. Inbreeding depression is ...
He crossed hooded rats with both wild and "Irish" types, and then back-crossed the offspring with pure hooded rats. The dark ... Clair Shores, MI: Scholarly Press. ISBN 978-0-403-01786-7. Levinson, Gene (2020). Rethinking evolution: the revolution that's ... Wright, Sewall (1932). "The Roles of Mutation, Inbreeding, Crossbreeding and Selection in Evolution". In Jones, Donald F. (ed ... Starting in 1906, William Castle carried out a long study of the effect of selection on coat colour in rats. The piebald or ...
He examined inbreeding in his writings, contrasting it with the advantages of outcrossing in many species. Despite his fears, ... In Australia, the marsupial rat-kangaroo and the platypus seemed so unusual that Darwin thought it was almost as though two ... saved them from being marooned on a nearby shore when a collapsing glacier caused a large wave that would have swept away their ... Whenever they fell ill, he feared that they might have inherited weaknesses from inbreeding due to the close family ties he ...
Black rats had been eating both tortoise eggs and hatchlings, effectively destroying the future of the tortoise population. ... Its genetic resistance to the negative effects of inbreeding would be another. Breeding and release programs began in 1965 and ... describing their examination of the southern shores of South America, and the Beagle's circumnavigation of the globe. Journal ... The introduction of black rats onto Pinzón sometime in the latter half of the 19th century had resulted in the complete ...
Fernando Sucre (played by Amaury Nolasco) is imprisoned at Fox River State Penitentiary for aggravated robbery and was ratted ... Though Bagwell initially believed himself to be incapable of fathering a child due to being conceived as a result of inbreeding ... He auditioned for the role while he had a recurring role as Tommy Ravetto on North Shore. ...
Disease relevance of Rats, Inbred SHR. *The spontaneously hypertensive rat (SHR), a widely used animal model of essential ... Associations of Rats, Inbred SHR with chemical compounds. *Clonidine and L-alpha-methylnoradrenaline (but not D-alpha- ... Psychiatry related information on Rats, Inbred SHR. *The influence of ethanol (alcohol) consumption on blood pressure during ... Biological context of Rats, Inbred SHR. *Direct gene delivery of human tissue kallikrein reduces blood pressure in ...
SHR) and Wistar-Kyoto (WKY) rats. Multifiber responses to a concentration series (0.5 … ... Rats, Inbred SHR * Rats, Inbred WKY * Sodium Chloride / pharmacology* * Taste / drug effects* ... SHR) and Wistar-Kyoto (WKY) rats. Multifiber responses to a concentration series (0.5 M to 2.0 M) of NaCl, KCl and NH4Cl were ... Lack of amiloride sensitivity in SHR and WKY glossopharyngeal taste responses to NaCl Physiol Behav. 1991 Oct;50(4):765-9. doi ...
Rats, Inbred F344 * Rats, Inbred SHR * Sulfur Dioxide / administration & dosage * Sulfur Dioxide / chemistry ... Methods: F344 and SHR rats and A/J, C57BL/6, and BALB/c mice were exposed 6 h/day 7 days/week for 1 week to 6 months to three ...
RatsRats, Inbred SHR • Signal Transduction • Sodium • Sodium Chloride • Systole • Urea • Urine. Curriculum Vitae. Current Ph ... Functional implications of sexual dimorphism of transporter patterns along the rat proximal tubule: modeling and analysis., ...
RatsRats, Inbred SHRRats, Wistar • Renal Circulation • Saccharomyces cerevisiae • Saccharomyces cerevisiae Proteins • ... Edwards, A; Layton, AT, Cell Volume Regulation in the Proximal Tubule of Rat Kidney : Proximal Tubule Cell Volume Regulation., ... Sgouralis, I; Evans, RG; Layton, AT, Renal medullary and urinary oxygen tension during cardiopulmonary bypass in the rat., ... Chen, Y; Sullivan, JC; Edwards, A; Layton, AT, Sex-specific computational models of the spontaneously hypertensive rat kidneys ...
SHR.BN-RT1n. A rat strain with the genetic background of SHR but which differs from that strain by the introduction of a ... 1.2 Rats. 2. Laboratory codes. 3. Inbred Strains and Hybrids. 3.1 Definition 3.2 Nomenclature of Inbred Strains. 3.3 Indication ... SHR-Chr YBN. In this consomic rat strain, the Y chromosome from BN has been backcrossed onto SHR. ... 4.3 Mixed Inbred Strains. Incipient inbred stocks or inbred strains that are derived from up to three parental strains (one of ...
... freely moving SHR and WKY rats and DOCA-salt hypertensive and normotensive Wistar rats. The eff ... Rats. Rats, Inbred SHR. Rats, Inbred WKY. Rats, Wistar. Chemical. Reg. No./Substance: 0/Endothelins; 64-85-7/ ... freely moving SHR and WKY rats and DOCA-salt hypertensive and normotensive Wistar rats. The effect of ET-3 on blood pressure ... and heart rats was investigated for four doses equal to 250 ng, 500 ng, 1000 ng and 2000 ng of ET-3. Our study shows that in ...
... and the in vivo overflow of endogenous and alpha-methylated catecholamines were measured in urethane anaesthetised rats after ... Rats. Rats, Inbred SHR. Chemical. Reg. No./Substance: 0/Biogenic Amines; 0/Catecholamines; 555-30-6/Methyldopa; 7440-09-7/ ... Next Document: The protective action of R56865 against ouabain-induced intoxication in rat heart isolated atria and.... ... and the in vivo overflow of endogenous and alpha-methylated catecholamines were measured in urethane anaesthetised rats after ...
Rats. Rats, Inbred SHR. Receptors, G-Protein-Coupled / metabolism. Renin / blood. Sodium Chloride, Dietary / toxicity*. ... SHR).. METHODS: Eight-week-old male spontaneously hypertensive rats (SHR) were given an 8% salt diet for 5 weeks (n = 8). Age- ... and receptor mas in response to a high salt diet in spontaneously hypertensive rats ( ...
Rats, Inbred SHR. 1. 2013. 218. 0.140. Why? Middle Aged. 14. 2021. 207860. 0.140. Why? ...
Ramipril improves hemodynamic recovery but not microvascular response to ischemia in spontaneously hypertensive rats. - ... Rats, Inbred SHR. Join CureHunter, for free Research Interface BASIC access!. Take advantage of free CureHunter research engine ... SHR). Unilateral limb ischemia was induced in 20-week-old SHR by surgically removing the left femoral artery. Rats were allowed ... The SHR failed to develop reparative angiogenesis in response to ischemia, thus having inadequate perfusion recovery. Ramipril ...
Rats, Inbred SHR. *Rats, Inbred WKY. *Small-Conductance Calcium-Activated Potassium Channels (metabolism) ... and mesenteric arteries were isolated from spontaneously hypertensive rats (SHR) and Wistar-Kyoto (WKY) rats. NO-, EDHF-, and ... Plasma levels of ADMA were significantly increased in SHR. In cultured endothelial cells, the expressions of SK3 mRNA and ... and plasma concentrations of ADMA were determined in rats. Cultured endothelial cells were treated with ADMA (1-10 microM) for ...
Resistance exercise trained rats had lower mean arterial pressure than untrained rats (RTHO: 159±2.2 vs SHO: 177±3.4 mmHg), as ... Rats, Inbred SHR. *Rats, Wistar. *Reproducibility of Results. *Time Factors. Related in: MedlinePlus ... Resistance exercise trained rats had lower mean arterial pressure than untrained rats (RTHO: 159±2.2 vs SHO: 177±3.4 mmHg), as ... Mentions: Ovariectomized hypertensive rats had a higher MAP than non-ovariectomized hypertensiverats (SHO vs SH group). Rats ...
The SHR congenic strain was derived from a progenitor strain of SHR (SHR/Ola) descended from inbred SHR originally obtained ... Wistar-Kyoto rats,2 3 SHR-stroke-prone×Wistar-Kyoto rats,6 and in a series of recombinant inbred strains derived from SHR×BN-Lx ... We measured blood pressure in 9 male congenic SHR.BN-D1Mit3/Igf2 rats and 12 male progenitor SHR rats in two separate studies. ... of the hypertension in SHR versus BN. This 10- to 15-mm Hg systolic BP difference between the SHR progenitor and SHR.BN-D1Mit3/ ...
Hendley ED, Wessel DJ, Van Houten J. (1986) Inbreeding of Wistar-Kyoto rat strain with hyperactivity but without hypertension. ... 1993) Spontaneously hypertensive rats (SHR) as a putative animal model of childhood hyperkinesis: SHR behavior compared to four ... A Behavioral Validation of the Spontaneously Hypertensive Rat (SHR) as an Animal Model of Attention-Deficit/Hyperactivity ... Russell, V. A. The nucleus accumbens motor-limbic interface of the Spontaneously Hypertensive Rat (SHR) as studied In-Vitro by ...
Genetic alterations include inbred strains (e.g., SHR, stroke-prone spontaneously hypertensive rats (SHRSP)) [23-26] or ... Myelin loss associated with neuroinflammation in hypertensive rats. Stroke. 2012;43:1115-22.PubMedPubMed CentralView Article ... Hypertensive rat strains can undergo white matter changes [23-26, 91]. SHRSP typically live for 9-12 months before developing ... Is the spontaneously hypertensive stroke prone rat a pertinent model of sub cortical ischemic stroke? A systematic review. Int ...
86) assessed renal function in F344/DuCrlCrlj rats, a substrain of the inbred Fischer 344 strain lacking DPP-4 enzyme activity ... 84) showed that sitagliptin enhances renovascular responses to AT-II in SHR rats; they also demonstrated that this effect ... 92) assessed whether vildagliptin had a renoprotective activity in STZ-induced diabetic rats. Diabetic and nondiabetic rats ... Beneficial effects of vildagliptin on retinal injury in obese type 2 diabetic rats. Ophthalmic Res 2013;50:221-226pmid:24081217 ...
Spontaneously hypertensive rats (SHR) were obtained from Harlan, Indianapolis. These inbred albino rats have been derived from ... In SHR stroke study 1, experimental stroke outcome data revealed that the Tocomin-fed rats tended (P=0.057, Figure 5E) to have ... SHR (n=42; male; 4 weeks old, Harlan) were randomly divided into 2 groups: control and supplemented. All rats were maintained ... Spontaneously Hypertensive Rat Stroke. Male SHR weighing 250 to 350 g were fasted for 24 hours before surgery. Because pre- ...
Between 1992 and 2000, 21papers1-21were published that used rats from inbred colonies in Melbourne and Tokyo thatwere believed ... in backcrossanalysis between SHR and Donryu rats.Clin Exp Pharmacol Physiol. . Suppl 1995; 1: S220-S222. ... Heart size in inbred strains of rats. Part 1. Genetic determinationof the development of cardiovascular enlargement in rats. ... Strain-specific deletions in exon 10 of rat K-kininogen andT1-kininogen genes allow mapping of both genes to rat chromosome11. ...
Basal plasma corticosterone levels of SHR and WKY males (M) and females (F), maternally separated (MS) or non-maternally ... In the present study we used an inbred animal model of ADHD, the spontaneously hypertensive rat (SHR), to investigate the long- ... In the present study we used an inbred animal model of ADHD, the spontaneously hypertensive rat (SHR), to investigate the long- ... to SHR and Wistar-Kyoto rats (WKY), the normotensive control strain from which SHR were originally derived. The effects of ...
SHR) and Wistar-Kyoto (WKY) rats. Blood pressure increased in SHROB (164 ± 7 mmHg) and decreased 10 mmHg when treated with ... SHR) and Wistar-Kyoto (WKY) rats. Blood pressure increased in SHROB (164 ± 7 mmHg) and decreased 10 mmHg when treated with ... SHR) and Wistar-Kyoto (WKY) rats. Blood pressure increased in SHROB (164 ± 7 mmHg) and decreased 10 mmHg when treated with ... SHR) and Wistar-Kyoto (WKY) rats. Blood pressure increased in SHROB (164 ± 7 mmHg) and decreased 10 mmHg when treated with ...
In the present study we used an inbred animal model of ADHD, the spontaneously hypertensive rat (SHR), to investigate the long- ... b. *WKY spent more time immobile than SHR (p , 0.01). #SHR males spent more time immobile than SHR females in the 1stminute (p ... to SHR and Wistar-Kyoto rats (WKY), the normotensive control strain from which SHR were originally derived. The effects of ... Maternal separation increased basal levels of corticosterone in SHR females (p , 0.05). (SHR males: nMS, n = 5, MS, n = 9; SHR ...
... agonists and antagonists on goal-directed behavior in SHR and the normotensive inbred control strain Wistar-Kyoto (WKY) rats. ... agonists and antagonists on goal-directed behavior in SHR and the normotensive inbred control strain Wistar-Kyoto (WKY) rats. ... Outcome-sensitive goal-directed behavior was restored in SHR rats following injection prior to the choice test of the dopamine ... Outcome-sensitive goal-directed behavior was restored in SHR rats following injection prior to the choice test of the dopamine ...
spontaneously hypertensive rat. the spontaneously hypertensive rat (SHR) is an inbred strain of genetically hypertensive rats ... SHR-captopril: 142 ± 11 mmHg, P, 0.05; SHR-captopril vs. SHR: 192 ± 14 mmHg;P , 0.01). Blood pressure rose in the SHR-captopril ... age-matched SHR and the WKY controls (WKY: 125 ± 13 vs. SHR-captopril: 171 ± 13, P , 0.01; SHR-captopril vs. SHR: 217 ± 18 mmHg ... 7, c-fos mRNA was readily detectable and equivalent in SHR and WKY rats. Treatment of the SHR with captopril had no effect on c ...
Weekly, 5 rats per group were sacrificed with a lethal injection of pentobarbital, and their kidneys were removed, decapsulated ... VDR and Hsp70 in kidneys from neonatal SHRs. If so, this may suggest that deregulation in the expression of WT-1 and its impact ... Male spontaneously hypertensive and control rats were evaluated weekly from birth until week 8 of life. Their blood pressure ... Finally, SHRs were originally inbred from Wistar rats and their Wistar-Kyoto (WKY) inbred non-hypertensive controls. These rats ...
WF rats (Iddm4 and Iddm5 on chromosomes 4 and 13, respectively) (18,19), and SHR rats (Iddm6 on the X chromosome) (20). These ... Markholst H, Andreasen B, Eastman S, Lernmark Å: Diabetes segregates as a single locus in crosses between inbred BB rats prone ... Introgression of F344 Rat Genomic DNA on BB Rat Chromosome 4 Generates Diabetes-Resistant Lymphopenic BB Rats. ... Introgression of F344 Rat Genomic DNA on BB Rat Chromosome 4 Generates Diabetes-Resistant Lymphopenic BB Rats ...
Rats, Rats, Inbred SHR, Reverse Transcriptase Polymerase Chain Reaction ... We found that distensibility was significantly improved in aortas from exercising compared with control rats (P < 0.0001). ... Gene expression profile and aortic vessel distensibility in voluntarily exercised spontaneously hypertensive rats: potential ... Exercising rats demonstrated a striking pattern of coordinated downregulation of genes belonging to the heat shock protein ...
Kinetics of GLUT4 trafficking in rat and human skeletal muscle. Karlsson, H. K. R., Chibalin, A. V., Koistinen, H. A., Yang, J ... Insulin regulates Rab3-Noc2 complex dissociation to promote GLUT4 translocation in rat adipocytes. Koumanov, F., Pereira, V. J ... Reduced insulin-stimulated GLUT4 bioavailability in stroke-prone spontaneously hypertensive rats. Collison, M., James, D. J., ... 5-aminoimidazole-4-carboxamide-1-β-D-ribofuranoside increases insulin-stimulated glucose uptake and GLUT4 translocation in rat ...
Inbred SHR Rats Vitamin D 2009 Potential cardioprotective role of liver cell-secreted factors in myocardial ischemia. Liu, S. Q ... Changes in the organization of the smooth muscle cells in rat vein grafts. Liu, S. Q. & Fung, Y. C., Dec 1 1998, In : Annals of ... Neointima formation on vascular elastic laminae and collagen matrices scaffolds implanted in the rat aortae. Liu, S. Q., Tieche ... A multi-physics growth model with fluid-structure interactions for blood flow and re-stenosis in rat vein grafts: A growth ...
Induction of hepatocytes in the pancreas of copper-depleted rats following copper repletion. Rao, M. S., Subbarao, V. & Reddy, ... Increased resistance of peroxisome proliferator-induced hepatic lesions to iron overload in rats. Rao, M. S., Subbarao, V. & ... Indomethacin inhibits thrombin-, but not thyroxin- stimulated resorption of fetal rat limb bones. Hoffmann, O., Klaushofer, K ... Increased calcium absorption in prehypertensive spontaneously hypertensive rat. Role of serum 1,25-dihydroxyvitamin D3 levels ...
  • The SHR.BN- D1Mit3/Igf2 congenic strain represents an important new model for fine mapping and characterization of genes on chromosome 1 involved in the pathogenesis of spontaneous hypertension. (ahajournals.org)
  • The spontaneously hypertensive rat is the most widely used animal model of human essential hypertension and has been studied extensively using physiological and biochemical approaches. (ahajournals.org)
  • These findings suggest that we have isolated a QTL-regulating blood pressure on chromosome 1 in the rat that appears to play a significant role in the pathogenesis of spontaneous hypertension. (ahajournals.org)
  • Loss of NHERF-1 Expression Prevents Dopamine-Mediated Na-K-ATPase Regulation in Renal Proximal Tubule Cells from Rat Models of Hypertension: Aged F344 Rats and Spontaneously Hypertensive Rats. (gwu.edu)
  • This abnormality is postulated to contribute to the hypertension characteristic of this strain of rats. (elsevier.com)
  • ACE inhibition and antioxidant activity, and then, the in vivo effect in short-term oral antihypertensive effect of hydrolyzed yeast fractions on a well characterized model to study hypertension - Spontaneously Hypertensive Rats (SHR). (unl.pt)
  • The involvement of brain dopamine in the development of hypertension in the spontaneously hypertensive rat (SHR) was studied. (edu.au)
  • Intracerebroventricular (i.c.v.) injections of 6-hydroxydopamine (6-OHDA) in young SHR caused depletion of dopamine in frontal cortex and striatum and induced an attenuation of the development of hypertension in SHR. (edu.au)
  • These data suggest that brain dopamine systems play a role in the development of hypertension in SHR and that especially the nigrostriatal system is important in this respect. (edu.au)
  • We here report that repeated lateral ventricular (LV) injection of GLP-1R agonist, liraglutide, once daily for 15 days counteracted the development of hypertension in spontaneously hypertensive rats (SHR). (nebraska.edu)
  • These findings demonstrate that the central GLP-1R signaling via NTS DBH neurons counteracts the development of hypertension in SHR, accompanied by attenuated sympathetic nerve activity. (nebraska.edu)
  • These results suggest that NC-1100 may be a drug inducing the increase of GABA in the cerebellum and medulla oblongata following continuous administration, especially in animals having hypertension associated cerebrovascular disorders such as SHR-SP. (muscimol.xyz)
  • Hyperresponsiveness of the renal vasculature to AA may be unique for the SHR, because it did not occur in Sprague-Dawley rats with angiotensin II-induced hypertension. (elsevier.com)
  • Abstract Recent linkage studies in the spontaneously hypertensive rat (SHR) suggest that a blood pressure regulatory gene or genes may be located on rat chromosome 1q. (ahajournals.org)
  • 18. Myers MM, Musty RE, Hendley ED. (1982) Attenuation of hyperactivity in the spontaneously hypertensive rat by amphetamine. (mcmaster.ca)
  • 20. Sagvolden T, Metzger MA, Schi rbeck HK, Rugland AL, Spinnangr I, Sagvolden G. (1992) The spontaneously hypertensive rat (SHR) as an animal model of childhood hyperactivity (ADHD): changed reactivity to reinforcers and to psychomotor stimulants. (mcmaster.ca)
  • 22. Wultz B, Sagvolden T. (1992) The hyperactive spontaneously hypertensive rat learns to sit still, but not to stop bursts of responses with short interresponse times. (mcmaster.ca)
  • In the present study we used an inbred animal model of ADHD, the spontaneously hypertensive rat (SHR), to investigate the long-term consequences of early life trauma on emotional behaviour in individuals predisposed to developing ADHD-like behaviour. (nih.gov)
  • the spontaneously hypertensive rat (SHR) is an inbred strain of genetically hypertensive rats that achieves plateau elevations in blood pressure at 16-20 wk of age. (physiology.org)
  • The spontaneously hypertensive rat (SHR) strain was developed by selecting brother-sister mating Wistar rats (WRs) with a hypertensive phenotype ( Okamoto and Aoki, 1963 ). (frontiersin.org)
  • The isolated and perfused kidney of the spontaneously hypertensive rat (SHR) exhibits an increased vascular reactivity and a delayed tachyphylaxis to serotonin (5-hydroxytryptamine) when compared with normotensive Wistar-Kyoto (WKY) rats. (meta.org)
  • Effect of NC-1100 [1-(3,4-dimethoxyphenyl)-2-(4-diphenylmethylpiperazinyl) ethanol dihydrochloride] on gamma-aminobutyric acid (GABA) metabolism in rat brain: analysis using stroke-prone spontaneously hypertensive rat. (muscimol.xyz)
  • We tested the hypothesis that cyclooxygenase-independent vasodilation produced by arachidonic acid (AA) is mediated by epoxyeicosatrienoic acids (EETs) and is blunted in the spontaneously hypertensive rat (SHR). (elsevier.com)
  • 1969 - Began offering rats, including Sprague Dawley, one of the most popular breeds of laboratory rat 1969 - Taconic was the first breeder to receive full accreditation from the American Association for the Accreditation of Laboratory Animals 1970 - Contracted to provide the National Institutes of Health with Sprague Dawley rats. (wikipedia.org)
  • We compared Spontaneously Hypertensive Rats (SHR), Fawn-Hooded (FH) rats, Wistar-Kyoto (WKY) rats, and Sprague-Dawley (SD) rats instrumented with radio-telemetry probes. (edu.au)
  • Production of inbred strains means that these backgrounds can be defined and thus require nomenclature conventions. (jax.org)
  • Laboratory rat strains derive from the Rattus norvegicus species. (jax.org)
  • Another species, Rattus rattus , also is used as an experimental model, but has not contributed to the common laboratory rat strains. (jax.org)
  • Rat strain names should be registered through the Rat Genome Database (RGD) at http://rgd.mcw.edu/tools/strains/strainRegistrationIndex.cgi . (jax.org)
  • Strains can be termed inbred if they have been mated brother x sister for 20 or more consecutive generations, and individuals of the strain can be traced to a single ancestral pair at the 20th or subsequent generation. (jax.org)
  • Inbred strains must be continuously mated brother x sister (or equivalent) thereafter. (jax.org)
  • Care should be taken that mouse and rat strains do not overlap in strain designations. (jax.org)
  • Inbred strains that have a common origin, but are separated before F20 are related inbred strains, and symbols should reflect this relationship. (jax.org)
  • 19. Sagvolden T, Hendley ED, Knardahl S. (1992) Behavior of hypertensive and hyperactive rat strains: Hyperactivity is not unitarily determined. (mcmaster.ca)
  • 1993) Spontaneously hypertensive rats (SHR) as a putative animal model of childhood hyperkinesis: SHR behavior compared to four other rat strains. (mcmaster.ca)
  • Similar to its reported effect in other rat strains, maternal separation increased the anxiety-like behaviour of WKY (decreased open arm entries) but not SHR. (nih.gov)
  • Rat strains have been previously shown to vary in their susceptibility to this parasite. (prolekare.cz)
  • We report here that rat macrophages from different inbred strains also vary in sensitivity to Toxoplasma induced lysis. (prolekare.cz)
  • However varying levels of resistance also exist among rat strains. (prolekare.cz)
  • Only macrophages from LT-sensitive rat strains undergo rapid caspase-1 dependent death (pyroptosis). (prolekare.cz)
  • The HXB/BXH recombinant inbred (RI) rat collection, developed from the SHR/Ola and BN-Lx congenic parental strains [5] - [7] , with opposing LT sensitivities, was used to map anthrax toxin susceptibility to a single locus at 55.8-58.1 Mb of rat chromosome 10. (prolekare.cz)
  • Our team has shown that the inbred rat strains Lewis (LEW) and Spontaneously Hypertensive Rats (SHR) differ with respect to several emotionalityrelated behaviors, one of which (inner locomotion in the open 﫿eld) was strongly in﫿uenced by a QTL (Anxrr16) on rat chromosome 4. (scirp.org)
  • In 2001, the International Committee on Standardized Nomenclature for Mice and the Rat Genome and Nomenclature Committee agreed to establish a joint set of rules for strain nomenclature, applicable to strains of both species. (jax.org)
  • 2. MAP increased with age in both strains but was 17-23% higher in SHR. (meta.org)
  • however, the extent of this involvement differs between rat strains and the drugs used. (edu.au)
  • The results obtained through both models were consistent and indicated that at higher drug doses, the performance of all three strains of rats deteriorated. (elsevier.com)
  • The results of DNA fingerprint and PCR microsatellite tests have confirmed that the SHR progenitor strain is highly inbred. (ahajournals.org)
  • To explore possible functional strain differences in taste receptors located on the posterior tongue, we recorded electrophysiological taste responses from the glossopharyngeal nerve of spontaneously hypertensive (SHR) and Wistar-Kyoto (WKY) rats. (nih.gov)
  • These results indicate that taste receptors innervated by the glossopharyngeal nerve lack amiloride sensitivity and that posterior taste receptor function to monochloride salts is equivalent between SHR and WKY. (nih.gov)
  • en] Both known estrogen receptors, ERalpha and ERbeta, are expressed in blood vessels. (uni.lu)
  • The responsiveness of central benzodiazepine and GABA(A) receptors in vasopressin and spontaneously hypertensive rats. (muscimol.xyz)
  • The increase in cytosol GABA-modulin activity in the anterior and posterior hypothalamus of spontaneously hypertensive rats (SHR) and of vasopressin hypertensive rats required much higher doses of muscimol than in normotensive animals showing subsensitivity of GABA(A) receptors in these brain structures. (muscimol.xyz)
  • In contrast, the sensitivities of GABA(A) receptors in the cerebellum and of benzodiazepine receptors in the hypothalamus and cerebellum were equal to hypertensive and normotensive rats. (muscimol.xyz)
  • Reference to former rules for rat strain nomenclature can be found in Committee on Rat Nomenclature (1992). (jax.org)
  • A key feature of mouse and rat nomenclature is the Laboratory Registration Code or Laboratory code, which is a code of usually three to four letters (first letter uppercase, followed by all lowercase) that identifies a particular institute, laboratory, or investigator that produced, and may hold stocks of, a mouse or rat strain. (jax.org)
  • An inbred strain should be designated by a unique brief symbol made up of uppercase, Roman, letters, or a combination of letters and numbers beginning with a letter. (jax.org)
  • Note: a few historical examples exist of similar mouse and rat strain designations and these are allowed to stand, with their substrain designations identifying them as unique). (jax.org)
  • To investigate this possibility, we replaced a region of chromosome 1 in the SHR (defined by the markers D1Mit3 and Igf2 ) with the corresponding chromosome segment from the normotensive Brown-Norway (BN) strain. (ahajournals.org)
  • Polymerase chain reaction genotyping using 60 polymorphic microsatellite markers dispersed throughout the genome confirmed the congenic status of the new strain designated SHR.BN- D1Mit3/Igf2 . (ahajournals.org)
  • 9 To confirm the presence of a putative BP QTL on chromosome 1 and to begin fine genetic mapping of specific variants responsible for increased blood pressure, we replaced an SHR chromosome 1 segment defined by the markers D1Mit3 and Igf2 with the corresponding chromosome region from the normotensive BN strain. (ahajournals.org)
  • We found that the systolic and diastolic BPs of the SHR congenic strain carrying the chromosome 1 segment transferred from the BN rat are significantly lower than the BPs of the progenitor SHR strain. (ahajournals.org)
  • The SHR congenic strain was derived from a progenitor strain of SHR (SHR/Ola) descended from inbred SHR originally obtained from the National Institutes of Health. (ahajournals.org)
  • This progenitor strain of SHR is commercially available in Europe and has been maintained by brother×sister mating at the Czech Academy of Sciences in Prague for more than 15 years. (ahajournals.org)
  • The SHR congenic strain was derived by a selective breeding protocol in which a segment of chromosome 1 from the normotensive BN/Cr strain was transferred onto the genetic background of the progenitor SHR. (ahajournals.org)
  • After 10 generations of selective back-crossing to the SHR progenitor strain, the differential chromosome segment was fixed using the markers D1Mit3 (a microsatellite marker that maps close to C ) and Igf2 and maintained in the homozygous state by brother×sister mating and selective inbreeding of the offspring. (ahajournals.org)
  • We applied a rodent model of early life trauma, maternal separation, to SHR and Wistar-Kyoto rats (WKY), the normotensive control strain from which SHR were originally derived. (nih.gov)
  • Between 1992 and 2000, 21papers 1-21 were published that used rats from inbred colonies in Melbourne and Tokyo thatwere believed to be of the Donryu (DRY) strain. (ahajournals.org)
  • These rats were thought tohave been the same strain as DRY used by Dr Tanase in early breedingexperiments in relation to blood pressure in spontaneously hypertensive rats(SHR). (ahajournals.org)
  • The purported DRY were never intended torepresent genetically appropriate controls for any strain, in particular SHR.Instead, they were intended simply as inbred normotensive controls, unrelatedto SHR and used to maximize the informativeness of the linkage analyses. (ahajournals.org)
  • Collectively, these data indicate that ACE inhibition during a critical period early in the life of the SHR can significantly reduce the elevations in blood pressure and end organ damage that characterize this strain. (physiology.org)
  • In this study, we examined the effects of specific dopamine receptor sub-type (D1 and D2) agonists and antagonists on goal-directed behavior in SHR and the normotensive inbred control strain Wistar-Kyoto (WKY) rats. (frontiersin.org)
  • These genetic factors therefore seem to be dependent on the rat strain used in the cross, i.e., influenced by a differing genome background. (diabetesjournals.org)
  • We described that the spontaneously hypertensive rats (SHR) strain presents a schizophrenia behavioral phenotype that is specifically attenuated by antipsychotic drugs, and potentiated by proschizophrenia manipulations. (frontiersin.org)
  • The aim of this study was to evaluate the effects of cannabinoid drugs on the deficit of prepulse inhibition (PPI) of startle, the main paradigm used to study sensorimotor gating impairment related to schizophrenia, presented by the SHR strain. (frontiersin.org)
  • Conversely, 0.75 mg/kg rimonabant decreased PPI in SHR strain, whereas AM404 did not modify it. (frontiersin.org)
  • Recently, our group has reported that the SHR strain, when compared to WRs, presents many behavioral changes that are specifically reversed by antipsychotic drugs and potentiated by proschizophrenia manipulations. (frontiersin.org)
  • The uptake and release of Ca2+ were studied in EGTA-skinned aortic strips from spontaneously hypertensive rats (SHR strain: SAP = 191 +/- 5 mmHg, n = 27) and normotensive control rats (WKY strain: SAP = 131 +/- 2 mmHg, n = 25). (nih.gov)
  • 1975 - Began offering the SHR hypertensive rat and the WKY control strain. (wikipedia.org)
  • This is the first demonstration of impaired Bezold-Jarisch responses in conscious SHR and provides evidence of both impaired vagally mediated arterial baroreceptor activity and impaired cardiopulmonary receptor activity in this rat strain. (austin.org.au)
  • Measurements and Main Results: Infarction volume in the striatum of SHR-SP (42 ± 4 mm 3 ) was greater than in SHR (20 ± 6 mm 3 ) or WKY (1 ± 1 mm 3 ) (n = g rats/strain). (utmb.edu)
  • The great omental arteries were isolated from essential hypertensive and normotensive patients, and mesenteric arteries were isolated from spontaneously hypertensive rats (SHR) and Wistar-Kyoto (WKY) rats. (curehunter.com)
  • Both NO- and EDHF -mediated endothelium-dependent responses were decreased in the great omental arteries of hypertensive patients and mesenteric arteries of SHR. (curehunter.com)
  • Ramipril improves hemodynamic recovery but not microvascular response to ischemia in spontaneously hypertensive rats. (curehunter.com)
  • We investigated whether chronic treatment with the ACE inhibitor ramipril may have a positive impact on the defective healing response to ischemia that is typical of spontaneously hypertensive rats (SHR). (curehunter.com)
  • Unilateral limb ischemia was induced in 20-week-old SHR by surgically removing the left femoral artery. (curehunter.com)
  • The SHR failed to develop reparative angiogenesis in response to ischemia , thus having inadequate perfusion recovery. (curehunter.com)
  • Cerebral perfusion, estimated with laser Doppler flowmetry (LD-CBF), in response to intravenous oxotremorine, was measured in one cohort of rats to estimate endothelial nitric oxide synthase function. (utmb.edu)
  • Background and Method: Both nitric oxide synthase (NOS) expression and oxidative stress are elevated in the tissues of spontaneously hypertensive rats (SHR) compared with Wistar-Kyoto rats (WKY). (elsevier.com)
  • To identify potential genetic factors of impulsivity, we examined common differentially expressed genes (DEGs) in the prefrontal cortex (PFC) of adolescent SHR/NCrl and Wistar rats, which showed marked decrease in preference for the large but delayed reward, compared with WKY/NCrl rats, in the delay discounting task. (nih.gov)
  • Prefrontal cortical genetic overlaps between SHR/NCrl and Wistar rats in comparison with WKY/NCrl included genes associated with transcription (e.g. (nih.gov)
  • Treatment with methylphenidate and/or atomoxetine increased choice of the large, delayed reward in SHR/NCrl and Wistar rats and changed, in varying degrees, mRNA levels of Nr4a2, Btg2, and Homer2, genes with previously described roles in neuropsychiatric disorders characterized by impulsivity. (nih.gov)
  • 2 3 4 5 6 7 Molecular analysis of these candidate genes in the SHR so far has been inconclusive. (ahajournals.org)
  • Therefore, despite linkage studies showing a BP QTL in the region of the Sa and Scnn1b genes, the identification and physical location of a BP QTL on rat chromosome 1 is far from certain. (ahajournals.org)
  • Gimap5 is a member of seven related genes located within 150 Kb on rat chromosome 4. (diabetesjournals.org)
  • Exercising rats demonstrated a striking pattern of coordinated downregulation of genes belonging to the heat shock protein family. (gu.se)
  • Nlrp1 genes from sensitive rat macrophages can confer sensitivity to this rapid cell death when expressed in Toxoplasma resistant rat macrophages. (prolekare.cz)
  • Other QTLs affecting neurobiological traits were also found on rat chromosome 4 and several candidate genes have been pointed out as possibly influencing those phenotypes. (scirp.org)
  • DI-fusion Localization of rat genes in the nitric oxid signaling. (ac.be)
  • We hypothesized that the PPARγ agonist, rosiglitazone in combination with a sEHi (tAUCB) will provide synergistic actions to decrease blood pressure, improve vascular function, decrease inflammation, and prevent renal damage in spontaneously hypertensive obese rats (SHROB). (elsevier.com)
  • Accordingly, unpublished results from our laboratory assays performed in adult spontaneously hypertensive rats (SHRs) suggested an opposite relationship between WT-1 renal expression and blood pressure values. (biomedcentral.com)
  • 70 to 90 mm Hg), AA constricted the renal vasculature in both SHR and normotensive Wistar-Kyoto rats, an effect abolished by cyclooxygenase inhibition, and converted to vasodilation when PP was raised to ≈200 mm Hg. (elsevier.com)
  • Results: Plasma and urinary hydrogen peroxide (H 2 O 2 ) and nitrate/nitrite (NOx), the renal NADPH oxidase activity and eNOS and nNOS expressions were all higher in SHR than in WKY. (elsevier.com)
  • Although the treatment with either the NADPH oxidase inhibitor, apocynin or the superoxide dismutase mimetic, tempol for 8 weeks decreased the systolic blood pressure (SBP) and inhibited the renal NADPH oxidase activity in SHR, apocynin decreased but tempol increased the plasma and urinary H2O2 and NOx and the eNOS and nNOS expressions in the renal cortex and medulla of SHR. (elsevier.com)
  • Results: Plasma and urinary hydrogen peroxide (H2O2) and nitrate/nitrite (NOx), the renal NADPH oxidase activity and eNOS and nNOS expressions were all higher in SHR than in WKY. (elsevier.com)
  • Vascular smooth muscle from stroke-prone spontaneously hypertensive rats has an increased responsiveness to the vasoconstrictors angiotensin II and serotonin. (elsevier.com)
  • In conclusion, we observed an increased response in carotid arteries from genetically hypertensive rats to a pharmacological intervention that appears to act via G protein-linked phospholipase C stimulation and L-type calcium channel activation, suggesting that the increased vascular reactivity in stroke-prone spontaneously hypertensive rats is due in part to altered function of G proteins. (elsevier.com)
  • Effects of oral administration of NC-1100 on the metabolism of neuroactive amino acids in rat brain were studied using stroke-prone spontaneously hypertensive (SHR-SP) and Wistar Kyoto rats. (muscimol.xyz)
  • Of these DEGs, we examined drug-responsive transcripts whose mRNA levels were altered following treatment (in SHR/NCrl and Wistar rats) with drugs that alleviate impulsivity, namely, the ADHD medications methylphenidate and atomoxetine. (nih.gov)
  • While further studies are required, we dissected potential genetic factors that may influence impulsivity by identifying genetic overlaps in the PFC of "impulsive" SHR/NCrl and Wistar rats. (nih.gov)
  • Wistar rats. (nih.gov)
  • The aim of the study was to investigate blood pressure responses and changes in heart rate after bolus administration of endothelin-3 [ET-3] in conscious, freely moving SHR and WKY rats and DOCA-salt hypertensive and normotensive Wistar rats. (biomedsearch.com)
  • The sarcoplasmic reticulum is characterized in the genetically hypertensive rats by a low transport activity of its Ca(2+)-ATPase, a high Ca2+ content and a Ca2+ release mechanism with low responsiveness to stimulation by caffeine, norepinephrine and IP3. (nih.gov)
  • In SHR(30) compared with WKY(30), we found significantly greater p22phox mRNA level, NADH/NADPH-driven *O(2)(-) production, media thickness, and cross-sectional area and an impaired vasodilation in response to acetylcholine. (unav.edu)
  • Is cardiovascular hypertrophy in young SHR the result of arecessive gene? (ahajournals.org)
  • Treatment of spontaneously hypertensive rats (SHR) with captopril (100 mg ⋅ kg −1 ⋅ day −1 ) throughout development and during the first 16 wk of life leads to a reduction in blood pressure and left ventricular hypertrophy. (physiology.org)
  • Blood pressures and hypertrophy are reduced in these animals (vs. untreated SHR) for up to 24 wk after discontinuation of the drug. (physiology.org)
  • This study demonstrates that captopril treatment during a critical period of development in the SHR leads to a sustained reduction in hypertrophy-dependent myocardial gene expression, which does not revert to levels seen in the untreated SHR after discontinuation of the drug. (physiology.org)
  • Intriguingly, several studies have shown that early treatment of the SHR with angiotensin-converting enzyme (ACE) inhibitors results in a sustained fall in blood pressure and a reduction in end organ sequelae (e.g., cardiac hypertrophy) that persists even after ACE inhibition is discontinued ( 9 , 25 ). (physiology.org)
  • Cardiac hypertrophy is a predictable sequelae of sustained elevations in blood pressure such as those seen in the SHR. (physiology.org)
  • Treatment of the mature SHR with ACE inhibitors results in a substantial reversal of cardiac hypertrophy ( 15 ). (physiology.org)
  • 9 ) and Wu and Berecek ( 25 ), in the studies cited above, provided preliminary data indicating that early treatment of the SHR with ACE inhibitors reduced the extent of cardiac hypertrophy in these animals. (physiology.org)
  • Objective: We examined the association of cardiac hypertrophy or fibrosis with the phospholipid fatty acid (FA) composition of heart and kidney in hypertensive rats. (elsevier.com)
  • Additionally, compared with WKYs, SHRs showed larger cardiomyocyte diameters in the left ventricles, indicating cardiac hypertrophy and interstitial fibrosis. (elsevier.com)
  • 1979) Patterns of behavioral development in spontaneously hypertensive rats and Wistar-Kyoto normotensive controls. (mcmaster.ca)
  • 17. Moser M-B, Moser EI, Wultz B, Sagvolden T. (1988) Component analyses differentiate between exploratory behaviour of spontaneously hypertensive rats and Wistar Kyoto rats in a two- compartment free-exploration open field. (mcmaster.ca)
  • SHROB were treated with rosiglitazone, tAUCB or the combination of tAUCB and rosiglitazone for four-weeks and compared with spontaneously hypertensive (SHR) and Wistar-Kyoto (WKY) rats. (elsevier.com)
  • 1. The aim of this study was to assess the vagal and sympathetic nerve contribution to the relationship between mean arterial pressure (MAP) and heart rate (HR) at 6, 9, 14 and 20 weeks of age in conscious Wistar-Kyoto (WKY) and spontaneously hypertensive rats (SHR) with methoxamine- and nitroprusside-induced steady-state changes in blood pressure. (meta.org)
  • Changes in isometric tension were recorded in denuded carotid artery strips from hypertensive and normotensive (Wistar-Kyoto) rats. (elsevier.com)
  • The activity of baroreceptor reflexes and cardiopulmonary reflexes was examined in conscious spontaneously hypertensive rats (SHR) and age-matched Wistar-Kyoto (WKY) rats. (austin.org.au)
  • Design and methods: Eight-week-old spontaneously hypertensive rats (SHRs) (n. =. 8) and Wistar Kyoto rats (WKYs, n. =. 8) as a normotensive control, were fed ad libitum for 6. (elsevier.com)
  • The study was performed in 16-week-old and 30-week-old normotensive Wistar-Kyoto rats (WKY(16) and WKY(30), respectively) and in 16-week-old and 30-week-old SHR (SHR(16) and SHR(30), respectively). (unav.edu)
  • In this experiment, we used a differential reinforcement of low rates (DRL) schedule to evaluate the performance of spontaneously hypertensive rats (SHR), Wistar Kyoto (WKY) and Wistar (WIS) rats, with the goal of dissociating the processes of timing and inhibition of responses through the use of two quantitative models: the peak deviation analysis and the temporal regulation model. (elsevier.com)
  • Austin Health Research Online: Impaired arterial baroreceptor reflex and cardiopulmonary vagal reflex in conscious spontaneously hypertensive rats. (austin.org.au)
  • Impaired arterial baroreceptor reflex and cardiopulmonary vagal reflex in conscious spontaneously hypertensive rats. (austin.org.au)
  • 1976) Selective brain dopamine depletion in developing rats: an experimental model of minimal brain dysfunction. (mcmaster.ca)
  • Outcome-sensitive goal-directed behavior was restored in SHR rats following injection prior to the choice test of the dopamine D2 receptor agonist Quinpirole or dopamine D1 receptor antagonist SCH23390, whereas WKY rats showed habitual responding following exposure to these drugs. (frontiersin.org)
  • Austin Health Research Online: Effect of angiotensin II on striatal dopamine release in the spontaneous hypertensive rat. (austin.org.au)
  • Effect of angiotensin II on striatal dopamine release in the spontaneous hypertensive rat. (austin.org.au)
  • We have previously demonstrated that angiotensin II stimulates the release of dopamine from the normotensive rat striatum via the AT1 receptor. (austin.org.au)
  • In this study, the effect of angiotensin II-stimulated striatal dopamine release in the spontaneous hypertensive rat was compared to normotensive controls. (austin.org.au)
  • Thus, despite reports of increased activity of the brain angiotensin II and dopamine systems in the spontaneous hypertensive rat, there is no evidence of abnormal regulation of the striatonigral dopamine system. (austin.org.au)
  • Experiments were designed to determine the involvement of products of cyclooxygenase in the augmented response and delayed tachyphylaxis to serotonin in the SHR kidney. (meta.org)
  • The vasoconstrictor responses to serotonin, norepinephrine and angiotensin II were exaggerated in the SHR kidney compared with that of the WKY rat. (meta.org)
  • Indomethacin did not affect the responsiveness to serotonin in the kidney of the SHR but increased the responses to the higher doses of the monoamine in the kidney of the WKY rats. (meta.org)
  • Results: Compared with WKYs, SHRs had lower proportions of γ-linolenic acid, α-linolenic acid, eicosadienoic acid, eicosatrienoic acid, dihomo-γ-linoleic acid, docosadienoic acid and nervonic acid in heart, and stearic acid (SA), γ-linolenic acid, and eicosapentaenoic acid (EPA) in kidney. (elsevier.com)
  • After adjusting for food intake, SHRs still maintained higher proportions of SA, and total saturated FAs in the heart and a lower proportion of eicosapentaenoic acid in the kidney. (elsevier.com)
  • The purpose of the present study was to determine the relationship between the endothelial and neuronal NOS (eNOS and nNOS) expression and oxidative stress in the kidney of SHR and WKY. (elsevier.com)
  • and that endogenous H2O2 is a mediator of the up-regulation of the NOS expression in the kidney of SHR. (elsevier.com)
  • In male SHR congenic rats carrying the transferred BN chromosome segment, 24-hour average systolic and diastolic blood pressures were significantly lower than in male progenitor SHR. (ahajournals.org)
  • Congenic DR. lyp/lyp rats, where BBDP lyp was introgressed onto the diabetes-resistant BBDR background (BBDR.BBDP. (diabetesjournals.org)
  • In an intercross between F1(BBDP x F344) rats, we identified a rat with a recombination event on chromosome 4, allowing us to fix 33 Mb of F344 between D4Rat253 and D4Rhw6 in the congenic DR. lyp rat line. (diabetesjournals.org)
  • In contrast, however, BioBreeding (BB) rat type 1 diabetes appears to be controlled by a limited number of genetic factors in inbred congenic BBDR.BBDP-(D4Mit6-D4Mit7)/Rhw (DR. lyp ) rats housed under specific pathogen-free conditions ( 7 - 9 ). (diabetesjournals.org)
  • Our approach to dissect the genetics of spontaneous diabetes in the BB rat was to initially develop lines congenic for lyp through introgression of the BBDP lyp locus onto BBDR to generate DR. lyp/lyp rats ( 7 ). (diabetesjournals.org)
  • 1994 - Contracted with National Institute for Allergy and Infectious Disease to maintain a repository of inbred, congenic, and transgenic mice. (wikipedia.org)
  • The aim of this study was to investigate the effects of resistance exercise training on hemodynamics and cardiac autonomic control in ovariectomized spontaneously hypertensive rats. (nih.gov)
  • Plasma levels of ADMA were significantly increased in SHR. (curehunter.com)
  • Mean arterial pressures of conscious captopril-treated rats, rats removed from captopril therapy, and the offspring of rats removed from therapy were significantly lower than those of control SHR at 4 and 9 mo of age. (physiology.org)
  • We found that distensibility was significantly improved in aortas from exercising compared with control rats (P (gu.se)
  • They conclude that housing rats in an enriched environment significantly increases spine density in superficial cortical layers in intact and lesioned brain, but in deeper layers of intact brain. (lu.se)
  • Vascular strips from the hypertensive rats had a significantly greater response to mastoparan at all concentrations between 10 −8 and 10 −5 mol/L. A G protein inhibitor, N-ethylmaleimide (10 −3 mol/L), attenuated the response to mastoparan (10 −7 mol/L) (67±4% of control response), whereas pertussis toxin treatment did not. (elsevier.com)
  • Phenyldiguanide elicited dose-dependent bradycardic and hypotensive responses in WKY rats, but these were significantly attenuated in SHR. (austin.org.au)
  • Although the activity of L-glutamic acid decarboxylase did not change in these cerebral areas, the activity of GABA-transaminase:succinic semialdehyde dehydrogenase was found to be significantly reduced in the cerebellum of SHR-SP following the repeated administration of NC-1100. (muscimol.xyz)
  • The turnover rate of GABA was also significantly reduced in the cerebellum and medulla oblongata of SHR-SP. (muscimol.xyz)
  • Whereas systolic blood pressure was significantly increased in the 2 groups of hypertensive animals compared with their normotensive controls, no differences were observed in systolic blood pressure between SHR(30) and SHR(16). (unav.edu)
  • Materials and methods: Chemical sympathectomy was produced in 12-week-old SHR by repeated injections of 6-hydroxydopamine, while control rats were given vehicle alone. (elsevier.com)
  • Since the animals used to study type 1 diabetes are highly inbred with a limited number of pathways to T1D, the relevance to human T1D has been questioned [ 9 ]. (hindawi.com)
  • Genome-wide linkage analysis for the diabetes phenotype have identified additional loci after crossing different inbred BB rats with DA rats ( Iddm3 on chromosome 18) ( 17 ), WF rats ( Iddm4 and Iddm5 on chromosomes 4 and 13, respectively) ( 18 , 19 ), and SHR rats ( Iddm6 on the X chromosome) ( 20 ). (diabetesjournals.org)
  • Male spontaneously hypertensive and control rats were evaluated weekly from birth until week 8 of life. (biomedcentral.com)
  • When expressed relative to the 0.5-M NH4Cl response, responses to the monochloride salts were equivalent between SHR and WKY. (nih.gov)
  • In this study, we aimed to investigate the effects of voluntary exercise on vascular mechanical properties and gene regulation patterns in spontaneously hypertensive rats. (gu.se)
  • To understand the link between vascular changes and white matter pathology, Rajani and colleagues studied a rat model of SVD. (sciencemag.org)
  • To gain further insight into the role of ERalpha in a functional setting, we investigated the effect of the novel highly selective ERalpha agonist Cpd1471 on vascular reactivity in ovariectomized spontaneously hypertensive rats (SHR). (uni.lu)
  • This study was designed to test the hypothesis that stimulation of nicotinamide adenine dinucleotide/nicotinamide adenine dinucleotide phosphate (NADH/NADPH) oxidase is involved in increased vascular superoxide anion (*O(2)(-)) production in spontaneously hypertensive rats (SHR). (unav.edu)
  • The vascular functional and morphological parameters were improved in SHR(30)-I. These findings suggest that an association exists between p22phox gene overexpression and NADH/NADPH overactivity in the aortas of adult SHR. (unav.edu)
  • The effect of ET-3 on blood pressure and heart rats was investigated for four doses equal to 250 ng, 500 ng, 1000 ng and 2000 ng of ET-3. (biomedsearch.com)
  • NO-, EDHF -, and prostaglandin (PGI(2))-mediated endothelium-dependent vasodilatation were measured, and plasma concentrations of ADMA were determined in rats. (curehunter.com)
  • In SHR after ovariectomy, endothelium-dependent NO-mediated vasorelaxation and eNOS expression are attenuated. (uni.lu)
  • Conclusions: Although SHR-SP have greater infarction volume than SHR, the mechanism of injury does not appear to be related to a difference in unanesthetized baseline mean arterial blood pressure or to an alteration in endothelium-produced nitric oxide. (utmb.edu)
  • Mice and rats used in the laboratory derive from a variety of sources. (jax.org)
  • Stroke-dependent brain tissue damage was studied in 12-Lox-deficient mice and spontaneously hypertensive rats orally supplemented with TCT. (ahajournals.org)
  • Rats, like humans, are quite resistant to Toxoplasma infection when compared to mice. (prolekare.cz)
  • We overviewed the pathophysiological features of diabetes in relation to its complications in type 1 and type 2 mice along with rat models, including Zucker Diabetic Fatty (ZDF) rats, BB rats, LEW 1AR1/-iddm rats, Goto-Kakizaki rats, chemically induced diabetic models, and Nonobese Diabetic mouse, and Akita mice model. (hindawi.com)
  • They produce selectively bred and genetically engineered mice and rats for research use. (wikipedia.org)
  • Effects of early life trauma are dependent on genetic predisposition: a rat study. (nih.gov)
  • Resistance exercise trained rats had lower mean arterial pressure than untrained rats (RTHO: 159±2.2 vs SHO: 177±3.4 mmHg), as well as resting bradycardia (RTHO: 332±9.0 vs SHO: 356±5 bpm). (nih.gov)
  • 6. Because the differences were confined to one effector, SHR may have different central rather than arterial baroreceptor afferent mechanisms. (meta.org)
  • Resting (unanesthetized) mean arterial blood pressure was similar in SHR-SP (177 ± 5 mm Hg) and SHR (170 ± 5 mm Hg) despite a greater infarction volume in SHR-SP (n = 4) compared with SHR (n = 5). (utmb.edu)
  • 6. Holene E, Nafstad I, Skaare JU, Bernhoft A, Engen P, Sagvolden T. (1995) Behavioral effects of pre- and postnatal exposure to individual polychlorinated biphenyl congeners in rats. (mcmaster.ca)
  • 8. Diaz-Granados JL, Greene PL, Amsel A. (1994) Selective activity enhancement and persistence in weanling rats after hippocampal X-irradiation in infancy: possible relevance for ADHD. (mcmaster.ca)
  • Therefore, the present study examined the changes in cardiac angiotensin-(1-7), its forming enzyme angiotensin converting enzyme 2 (ACE2) and receptor mas in response to a high salt diet in spontaneously hypertensive rats (SHR). (biomedsearch.com)
  • However, in this cohort, cortical infarction volume was less in SHR (30% ± 4% of ipsilateral cortex) than in SHR-SP (40% ± 2% of ipsilateral cortex). (utmb.edu)
  • We previously showed that Spontaneously Hypertensive Rats (SHR), an inbred rodent model of ADHD, show impairments in goal-directed action control, and instead are predominated by habits. (frontiersin.org)
  • Drugs that stabilized endothelial cells could reverse the white matter abnormalities in early-stage SVD in the rat model, suggesting a potential therapeutic approach. (sciencemag.org)
  • Improvement of endothelial dysfunction by selective estrogen receptor-alpha stimulation in ovariectomized SHR. (uni.lu)
  • Aortic endothelial NO synthase (eNOS) expression and phosphorylation of the vasodilator-stimulated phosphoprotein, an index of NO/cGMP-signaling, was reduced in ovariectomized SHR and normalized by E2 and Cpd1471. (uni.lu)
  • Oral supplementation of TCT to spontaneously hypertensive rats led to increased TCT levels in the brain. (ahajournals.org)
  • Fischer (CDF) and Brown Norway (BN) rats, however, are susceptible to chronic infection and develop transmissible cysts in their brain and muscle tissue [2] , [3] . (prolekare.cz)
  • SVD rats had a mutation in an ATPase, which was also found in SVD human brain tissue. (sciencemag.org)
  • Neuronal plasticity and dendritic spines: effect of environmental enrichment on intact and postischemic rat brain. (lu.se)
  • Angiotensin peptides in spontaneously hypertensive and normotensiveDonryu rats. (ahajournals.org)
  • Here, it was demonstrated that the fraction with molecular weight below 3 kDa containing tri and tetra- peptides with hydrophobic amino acid residues - SPQW, PWW and RYW, causes the most noticeable decrease in systolic, diastolic and mean blood pressure of SHR and shows highest antioxidant effect. (unl.pt)
  • Dynamic resistance training decreases sympathetic tone in hypertensive ovariectomized rats. (nih.gov)
  • Objective: To determine whether spectral powers of blood pressure and pulse interval can specifically reflect sympathetic and parasympathetic effects in unanesthetized, free-moving spontaneously hypertensive rats (SHR). (elsevier.com)
  • 5. It was concluded that older SHR have normal sympathetic but reduced vagal capacity to control HR in response to changes in MAP, but that this deficit was not dependent on the absolute level of blood pressure. (meta.org)