AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and Processes
Rats, Inbred LewRats, Inbred BNAnimals, CongenicRats, Inbred F344Coronavirus, RatVesicle-Associated Membrane Protein 1Rats, Inbred StrainsRats, Inbred WFHistocompatibility AntigensOrganogold CompoundsDimercaprolArthritisSpecies SpecificityMercuric ChlorideMycoplasma InfectionsMycoplasmaGraft RejectionIsoantibodiesMajor Histocompatibility ComplexArthritis, ExperimentalBenzyl CompoundsChromosomes, MammalianTransplantation, HomologousAzaserineParvovirusDisease SusceptibilityRodent DiseasesPneumonia, MycoplasmaRats, Mutant StrainsGraft SurvivalPhosphoglycerate MutaseHeart TransplantationHyperplasiaAdventitiaTunica IntimaCarotid Artery InjuriesConnective TissueCytomegalovirus InfectionsMuscle, Smooth, Vascular
Rats, Inbred Lew
Rats, Inbred BN
Animals, Congenic
Animals that are produced through selective breeding to eliminate genetic background differences except for a single or few specific loci. They are used to investigate the contribution of genetic background differences to PHENOTYPE.
Rats, Inbred F344
Coronavirus, Rat
A species of CORONAVIRUS causing pneumonia in newborn rats but a clinically inapparent infection in adults. It is separate but antigenically related to MURINE HEPATITIS VIRUS.
Vesicle-Associated Membrane Protein 1
A member of the vesicle-associated membrane protein family involved in the MEMBRANE FUSION of TRANSPORT VESICLES to their target membrane.
Rats, Inbred Strains
Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations or by parent x offspring matings carried out with certain restrictions. This also includes animals with a long history of closed colony breeding.
Rats, Inbred WF
Histocompatibility Antigens
A group of antigens that includes both the major and minor histocompatibility antigens. The former are genetically determined by the major histocompatibility complex. They determine tissue type for transplantation and cause allograft rejections. The latter are systems of allelic alloantigens that can cause weak transplant rejection.
Organogold Compounds
Organic compounds that contain GOLD as an integral part of the molecule. Some are used as ANTIRHEUMATIC AGENTS. The term chrysotherapy derives from an ancient Greek term for gold.
Dimercaprol
An anti-gas warfare agent that is effective against Lewisite (dichloro(2-chlorovinyl)arsine) and formerly known as British Anti-Lewisite or BAL. It acts as a chelating agent and is used in the treatment of arsenic, gold, and other heavy metal poisoning.
Arthritis
Species Specificity
The restriction of a characteristic behavior, anatomical structure or physical system, such as immune response; metabolic response, or gene or gene variant to the members of one species. It refers to that property which differentiates one species from another but it is also used for phylogenetic levels higher or lower than the species.
Mercuric Chloride
Mercury chloride (HgCl2). A highly toxic compound that volatizes slightly at ordinary temperature and appreciably at 100 degrees C. It is corrosive to mucous membranes and used as a topical antiseptic and disinfectant.
Mycoplasma Infections
Infections with species of the genus MYCOPLASMA.
Mycoplasma
A genus of gram-negative, mostly facultatively anaerobic bacteria in the family MYCOPLASMATACEAE. The cells are bounded by a PLASMA MEMBRANE and lack a true CELL WALL. Its organisms are pathogens found on the MUCOUS MEMBRANES of humans, ANIMALS, and BIRDS.
Graft Rejection
An immune response with both cellular and humoral components, directed against an allogeneic transplant, whose tissue antigens are not compatible with those of the recipient.
Isoantibodies
Antibodies from an individual that react with ISOANTIGENS of another individual of the same species.
Major Histocompatibility Complex
The genetic region which contains the loci of genes which determine the structure of the serologically defined (SD) and lymphocyte-defined (LD) TRANSPLANTATION ANTIGENS, genes which control the structure of the IMMUNE RESPONSE-ASSOCIATED ANTIGENS, HUMAN; the IMMUNE RESPONSE GENES which control the ability of an animal to respond immunologically to antigenic stimuli, and genes which determine the structure and/or level of the first four components of complement.
Arthritis, Experimental
ARTHRITIS that is induced in experimental animals. Immunological methods and infectious agents can be used to develop experimental arthritis models. These methods include injections of stimulators of the immune response, such as an adjuvant (ADJUVANTS, IMMUNOLOGIC) or COLLAGEN.
Benzyl Compounds
Chromosomes, Mammalian
Complex nucleoprotein structures which contain the genomic DNA and are part of the CELL NUCLEUS of MAMMALS.
Transplantation, Homologous
Transplantation between individuals of the same species. Usually refers to genetically disparate individuals in contradistinction to isogeneic transplantation for genetically identical individuals.
Azaserine
Antibiotic substance produced by various Streptomyces species. It is an inhibitor of enzymatic activities that involve glutamine and is used as an antineoplastic and immunosuppressive agent.
Parvovirus
A genus of the family PARVOVIRIDAE, subfamily PARVOVIRINAE, infecting a variety of vertebrates including humans. Parvoviruses are responsible for a number of important diseases but also can be non-pathogenic in certain hosts. The type species is MINUTE VIRUS OF MICE.
Disease Susceptibility
A constitution or condition of the body which makes the tissues react in special ways to certain extrinsic stimuli and thus tends to make the individual more than usually susceptible to certain diseases.
Rodent Diseases
Diseases of rodents of the order RODENTIA. This term includes diseases of Sciuridae (squirrels), Geomyidae (gophers), Heteromyidae (pouched mice), Castoridae (beavers), Cricetidae (rats and mice), Muridae (Old World rats and mice), Erethizontidae (porcupines), and Caviidae (guinea pigs).
Pneumonia, Mycoplasma
Interstitial pneumonia caused by extensive infection of the lungs (LUNG) and BRONCHI, particularly the lower lobes of the lungs, by MYCOPLASMA PNEUMONIAE in humans. In SHEEP, it is caused by MYCOPLASMA OVIPNEUMONIAE. In CATTLE, it may be caused by MYCOPLASMA DISPAR.
Rats, Mutant Strains
Rats bearing mutant genes which are phenotypically expressed in the animals.
Graft Survival
The survival of a graft in a host, the factors responsible for the survival and the changes occurring within the graft during growth in the host.
Phosphoglycerate Mutase
An enzyme that catalyzes the conversion of 2-phospho-D-glycerate to 3-phospho-D-glycerate. EC 5.4.2.1.
Heart Transplantation
The transference of a heart from one human or animal to another.
Hyperplasia
An increase in the number of cells in a tissue or organ without tumor formation. It differs from HYPERTROPHY, which is an increase in bulk without an increase in the number of cells.
Adventitia
The outermost covering of organs, blood vessels, and other such structures in the body.
Tunica Intima
The innermost layer of an artery or vein, made up of one layer of endothelial cells and supported by an internal elastic lamina.
Carotid Artery Injuries
Damages to the CAROTID ARTERIES caused either by blunt force or penetrating trauma, such as CRANIOCEREBRAL TRAUMA; THORACIC INJURIES; and NECK INJURIES. Damaged carotid arteries can lead to CAROTID ARTERY THROMBOSIS; CAROTID-CAVERNOUS SINUS FISTULA; pseudoaneurysm formation; and INTERNAL CAROTID ARTERY DISSECTION. (From Am J Forensic Med Pathol 1997, 18:251; J Trauma 1994, 37:473)
Connective Tissue
Tissue that supports and binds other tissues. It consists of CONNECTIVE TISSUE CELLS embedded in a large amount of EXTRACELLULAR MATRIX.
Cytomegalovirus Infections
Infection with CYTOMEGALOVIRUS, characterized by enlarged cells bearing intranuclear inclusions. Infection may be in almost any organ, but the salivary glands are the most common site in children, as are the lungs in adults.
Muscle, Smooth, Vascular
The nonstriated involuntary muscle tissue of blood vessels.

Gamma interferon stimulates rat alveolar macrophages to kill Pneumocystis carinii by L-arginine- and tumor necrosis factor-dependent mechanisms. (1/4121)

Pneumocystis carinii pneumonia remains a serious complication for immunocompromised patients. In the present study, P. carinii organisms interacted with gamma interferon (IFN-gamma)-stimulated alveolar macrophages (AMs) to activate the L-arginine-dependent cytocidal pathway involving reactive nitrogen intermediates (RNI) that were assayed as nitrite (NO2-). Unstimulated cultures of AMs produced negligible quantities of RNI. Addition of P. carinii organisms to IFN-gamma-primed AMs resulted in greatly enhanced production of RNI. NO2- levels increased from 0.8 +/- 0.4 to 11.1 +/- 3.8 microM as early as 6 h after P. carinii organisms were incubated with IFN-gamma-stimulated AMs and to 35.1 +/- 8.9 microM after a 24-h incubation, a near-maximum level. High levels of NO2- were produced by AMs primed with as little as 10 U of IFN-gamma per ml in the presence of P. carinii, and a 20-fold increase in IFN-gamma concentration resulted in only a further 65% increase in NO2- production. RNI-dependent killing of P. carinii was demonstrated by both a 51Cr release assay and a [35S]methionine pulse immunoprecipitation assay. Addition of either monoclonal tumor necrosis factor alpha (TNF-alpha) neutralizing antibody or 200 microM NG-monomethyl-L-arginine (L-NGMMA), a competitive inhibitor of the L-arginine-dependent pathway, significantly decreased NO2- production and reduced P. carinii killing. TNF-alpha alone had no effect on P. carinii viability. These results suggest that (i) the specific interaction of P. carinii organisms with IFN-gamma-primed AMs triggers the production of RNI, (ii) RNI are toxic to P. carinii, and (iii) TNF-alpha likely plays a central role in mediating P. carinii killing by IFN-gamma-stimulated AMs.  (+info)

Proteinuria induces tubular cell turnover: A potential mechanism for tubular atrophy. (2/4121)

BACKGROUND: Proteinuria and tubular atrophy have both been closely linked with progressive renal failure. We hypothesized that apoptosis may be induced by tubular cell exposure to heavy proteinuria, potentially leading to tubular atrophy. Apoptosis was studied in a rat model of "pure" proteinuria, which does not induce renal impairment, namely protein-overload proteinuria. METHODS: Adult female Lewis rats underwent intraperitoneal injection of 2 g of bovine serum albumin (BSA, N = 16) or sham saline injections (controls, N = 8) daily for seven days. Apoptosis was assessed at day 7 in tissue sections using in situ end labeling (ISEL) and electron microscopy. ISEL-positive nuclei (apoptotic particles) were counted in blinded fashion using image analysis with NIH Image. Cell proliferation was assessed by detection of mRNA for histone by in situ hybridization, followed by counting of positive cells using NIH Image. RESULTS: Animals injected with saline showed very low levels of apoptosis on image analysis. BSA-injected rats had heavy proteinuria and showed both cortical and medullary apoptosis on ISEL. This was predominantly seen in the tubules and, to a lesser extent, in the interstitial compartment. Overall, the animals injected with BSA showed a significant 30-fold increase in the number of cortical apoptotic particles. Electron microscopy of tubular cells in a BSA-injected animal showed a progression of ultrastructural changes consistent with tubular cell apoptosis. The BSA-injected animals also displayed a significant increase in proximal tubular cell proliferation. This increased proliferation was less marked than the degree of apoptosis. CONCLUSION: Protein-overload proteinuria in rats induces tubular cell apoptosis. This effect is only partially balanced by proliferation and potentially provides a direct mechanism whereby heavy proteinuria can induce tubular atrophy and progressive renal failure.  (+info)

Endothelin up-regulation and localization following renal ischemia and reperfusion. (3/4121)

BACKGROUND: Endothelin (ET), a potent vasoconstrictor, is known to play a role in ischemic acute renal failure. Although preproET-1 (ppET-1) mRNA is known to be up-regulated following ischemia/reperfusion injury, it has not been determined which component of the injury (ischemia or reperfusion) leads to initial gene up-regulation. Likewise, although ET-1 peptide expression has been localized in the normal kidney, its expression pattern in the ischemic kidney has not been determined. Therefore, the purpose of this study was twofold: (a) to determine whether ischemia alone or ischemia plus reperfusion is required for the up-regulation of ppET-1 mRNA to occur, and (b) to localize ET-1 peptide expression following ischemia in the rat kidney to clarify better the role of ET in the pathophysiology of ischemia-induced acute renal failure. METHODS: Male Lewis rats underwent clamping of the right renal vascular pedicle for either 30 minutes of ischemia (group 1), 60 minutes of ischemia (group 2), 30 minutes of ischemia followed by 30 minutes of reperfusion (group 3), or 60 minutes of ischemia followed by three hours of reperfusion (group 4). The contralateral kidney acted as a control. ppET-1 mRNA up-regulation and ET-1 peptide expression were examined using the reverse transcription-polymerase chain reaction and immunohistochemistry, respectively. RESULTS: Reverse transcription-polymerase chain reaction yielded a control (nonischemic) value of 0.6 +/- 0.2 densitometric units (DU) of ppET-1 mRNA in the kidney. Group 1 levels (30 min of ischemia alone) were 1.8 +/- 0.4 DU, a threefold increase (P < 0.05). Group 2 levels (60 min of ischemia alone) increased almost six times above baseline, 3.5 +/- 0.2 DU (P < 0.01), whereas both group 3 and group 4 (ischemia plus reperfusion) did not experience any further significant increases in mRNA levels (1.9 +/- 0.4 DU and 2.8 +/- 0.6 DU, respectively) beyond levels in group 1 or 2 animals subjected to similar ischemic periods. ET-1 peptide expression in the ischemic kidneys was significantly increased over controls and was clearly localized to the endothelium of the peritubular capillary network of the kidney. CONCLUSIONS: Initial ET-1 gene up-regulation in the kidney occurs secondary to ischemia, but reperfusion most likely contributes to sustaining this up-regulation. The marked increase of ET-1 in the peritubular capillary network suggests that ET-induced vasoconstriction may have a pathophysiological role in ischemic acute tubular necrosis.  (+info)

Characterization of CD4+ CD8alphaalpha+ and CD4-CD8alphaalpha+ intestinal intraepithelial lymphocytes in rats. (4/4121)

Intestinal intraepithelial lymphocytes (i-IEL) of aged rats comprise CD4+CD8alphaalpha+ and CD4-CD8alphaalpha+ T cells expressing TCR alphabeta. In the present study, we compared characteristics between CD4+CD8alphaalpha+ and CD4-CD8alphaalpha+ i-IEL, which were purified by a cell sorter from the i-IEL of 6-month-old Lewis rats. Most of the CD4+CD8alphaalpha+ i-IEL were of the CD44(hlgh) phenotype, while CD4-CD8alphabeta+ i-IEL were CD44(low). Vbeta usage in the CD4-CD8alphaalpha+ i-IEL was much diversified, while CD4+CD8alphaalpha+ i-IEL showed a skewed Vbeta repertoire. The CD4+CD8alphaalpha+ i-IEL but not the CD4-CD8alphaalpha+ i-IEL proliferated in response to syngeneic spleen cells, which was partially inhibited by addition of anti-MHC class I mAb. The CD4+CD8alphaalpha+ i-IEL produced IFN-gamma and IL-2 but no IL-4 or transforming growth factor (TGF)-beta in response to syngeneic spleen cells, while CD4-CD8alphaalpha+ i-IEL produced abundant levels of TGF-beta but no IL-2, IFN-gamma or IL-4. CD4+CD8alphaalpha+ i-IEL proliferated in response to exogenous IL-2 but not to IL-15, while CD4-CD8alphaalpha+ i-IEL could respond to IL-15 as well as IL-2. These results suggest that a significant fraction of CD4+CD8alphaalpha+ i-IEL belongs to Th1-type T cells capable of responding to self-MHC class I, while CD4-CD8alphaalpha+ i-IEL are a unique population with a diversified Vbeta repertoire that respond to IL-15 in rats.  (+info)

Hormonal prevention of breast cancer: mimicking the protective effect of pregnancy. (5/4121)

Full term pregnancy early in life is the most effective natural protection against breast cancer in women. Rats treated with chemical carcinogen are similarly protected by a previous pregnancy from mammary carcinogenesis. Proliferation and differentiation of the mammary gland does not explain this phenomenon, as shown by the relative ineffectiveness of perphenazine, a potent mitogenic and differentiating agent. Here, we show that short term treatment of nulliparous rats with pregnancy levels of estradiol 17beta and progesterone has high efficacy in protecting them from chemical carcinogen induced mammary cancers. Because the mammary gland is exposed to the highest physiological concentrations of estradiol and progesterone during full term pregnancy, it is these elevated levels of hormones that likely induce protection from mammary cancer. Thus, it appears possible to mimic the protective effects of pregnancy against breast cancer in nulliparous rats by short term specific hormonal intervention.  (+info)

Non-coding plasmid DNA induces IFN-gamma in vivo and suppresses autoimmune encephalomyelitis. (6/4121)

Regulatory sequences used in plasmids for naked DNA vaccination can modulate cytokine production in vivo. We demonstrate here that injection of plasmid DNA can suppress the prototypic T cell-mediated autoimmune disease, experimental autoimmune encephalomyelitis, by inducing IFN-gamma.  (+info)

Decreased hexosamine biosynthesis in GH-deficient dwarf rat muscle. reversal with GH, but not IGF-I, therapy. (7/4121)

Enhanced glucose flux via the hexosamine biosynthesis pathway (HNSP) has been implicated in insulin resistance. We measured L-glutamine:D-fructose-6-phosphate amidotransferase activity (GFAT, a rate-limiting enzyme) and concentrations of UDP-N-acetyl hexosamines (UDP-HexNAc, major products of HNSP) in muscle and liver of growth hormone (GH)-deficient male dwarf (dw) rats. All parameters measured, except body weight, were similar in 5-wk-old control and dw rats. Muscle GFAT activity declined progressively with age in controls and dw rats but was consistently 30-60% lower in 8- to 14-wk-old dw rats vs. age-matched controls; UDP-HexNAc concentrations in muscle were concomitantly 30% lower in dw rats vs. controls (P < 0.01). Concentrations of UDP-hexoses, GDP-mannose, and UDP in muscle were similar in control and dw rats. Muscle HNSP activity was similarly diminished in fed and fasted dw rats. In liver, only a small difference in GFAT activity was evident between controls and dw rats, and no differences in UDP-HexNAc concentrations were observed. Treatment with recombinant human GH (rhGH) for 5 days restored UDP-HexNAc to control levels in dw muscles (P < 0.01) and partially restored GFAT activity. Insulin-like growth factor I treatment was ineffective. We conclude that GH participates in HNSP regulation in muscle.  (+info)

Decreased lactic acidosis and anemia after transfusion of o-raffinose cross-linked and polymerized hemoglobin in severe murine malaria. (8/4121)

Severe anemia is a major cause of death in falciparum malaria. Blood transfusion increases survival in humans and in animal models of this disease. Because of logistic constraints and viral contamination of the blood supply, transfusions are frequently not practical in endemic regions. Modified hemoglobin is an effective O2 carrier in hemorrhagic shock. It is free of infectious contamination, may not require refrigeration, and because of its nitric oxide scavenging and small size, may have pharmacologic benefits in malaria. The effects of transfusions of modified hemoglobin in rats with high-grade parasitemia were evaluated. Modified hemoglobin decreased lactic acidosis and corrected anemia as well as transfusions with red blood cells; these findings may correlate with improved survival and suggest a possible proerythropoietic effect. Further study of this novel therapy is warranted.  (+info)

SAT0073 Theranostic approach in arthritis: A feasibility study in rats | Annals of the Rheumatic DiseasesSAT0073 Theranostic approach in arthritis: A feasibility study in rats | Annals of the Rheumatic Diseases
Methods Inflammatory arthritis was induced by twice injections of bovine collagen II (day 0, day 7) in female Lewis rats. Rats were monitored for joint swelling, pain, redness and mobility (score 0 to 3). The TNFa binding protein etanercept (Enbrel®, Pfizer) was chemically conjugated with an ICG derivative suited for labeling of proteins. The etanercept-6S-ICG (Eta-6S-ICG) conjugate was photophysically characterized and tested for binding affinity The fluorescence camera system Xiralite (mivenion GmbH, Germany) [1] was modified to enable imaging of rats. On day 14 after first injection of collagen, Eta-6S-ICG (n=6), IgG-6S-ICG (n=3), or the inflammation-targeted macromolecule polyglycerolsulfate-6S-ICG (dPGS-6S-ICG, n=5) [2] were s.c. or i.v. injected in a dose of 10 nMol/kg b.w. Fluorescence measurement was performed before and 1 h, 3 h, 24 h and 48 h after injection. Fluorescence intensity (FI) was measured in ROI over the tibio-tarsal and interphalangeal articulations and compared with ...
http://ard.bmj.com/content/71/Suppl_3/494.3
Topically Administered Mouse IgG1 Accumulates In the Rat Optic Nerve And Retina | IOVS | ARVO JournalsTopically Administered Mouse IgG1 Accumulates In the Rat Optic Nerve And Retina | IOVS | ARVO Journals
Purpose: Frequent intravitreal injections of monoclonal anti-VEGF agents Lucentis and Avastin were shown to reverse the effects of wet AMD. These injections, however, predispose patients to endophthalmitis and stroke, among other ocular and systemic adverse effects. Such complications, as well as patient discomfort, would be potentially reduced or even eliminated by the delivery of these drugs in mist or drop form. The purpose of this study was to obtain pilot data regarding the feasibility of delivering potentially therapeutic large, hydrophilic antibodies to the posterior pole by eye drop application.. Methods: Female Lewis rats received a single 25 mg/10 µL topical dose of whole mouse monoclonal IgG1 antibody in PBS without a permeation enhancer into one eye; control rats were left untreated. The concentration of IgG1 was determined in retinal and optic nerve homogenates 10 to 20 minutes later using an ELISA; tissues were homogenized in lysis buffer containing protease inhibitors. Data are ...
http://iovs.arvojournals.org/article.aspx?articleid=2145661
Potassium Channel Distribution, Clustering, and Function in Remyelinating Rat Axons | Journal of NeurosciencePotassium Channel Distribution, Clustering, and Function in Remyelinating Rat Axons | Journal of Neuroscience
Demyelination. Adult female Lewis rats were anesthetized, and the sciatic nerve in one leg, just proximal to the sciatic notch, was exposed. The three branches of the sciatic nerve were injected with 1-2 μl of 1% lysolecithin in sterile Lockes solution by using a glass micropipette broken to a tip diameter of ∼20 μm. Then the incision was closed, and the animal was allowed to recover for 6-69 d. Some animals were injected with both lysolecithin and mitomycin-C (400 mg/ml; Sigma, St. Louis, MO) to block Schwann cell proliferation subsequent to demyelination. The Lockes solution contained (in mm): NaCl 154, KCl 5.6, CaCl2 2, and HEPES 10, pH 7.4.. Axon preparation. On the appropriate day postinjection, the animal was killed; the sciatic nerve was dissected immediately, desheathed, and dissociated into single fibers by treatment with collagenase (3.6 mg/ml; Sigma) for 1 hr at room temperature (RT). Fibers were teased apart gently and spread on coverslips that had been coated in a few spots ...
https://www.jneurosci.org/content/18/1/36?ijkey=9cc347ba7b9384c74d557702f16f413bcd8a01c2&keytype2=tf_ipsecsha
Origin of macrophages in central nervous tissue. A study using intraperitoneal transplants contained in Millipore diffusion...Origin of macrophages in central nervous tissue. A study using intraperitoneal transplants contained in Millipore diffusion...
In order to determine the origin of brain phagocytes brain slices and optic nerve segments from adult Lewis rats were transplanted into the peritoneal cavity of syngenic recipients. The specimens were contained in Millipore diffusion chambers fitted with membranes of either 0.22 or 5.0 microns pore size. The either blocked or allowed the access of non-resident cells. Each recipient rat received both a 0.22 and 5.0 microns pore chamber. Later (3-16 days), the specimens were recovered and analyzed by monoclonal antibody techniques and electron-microscopy. Endothelia, GFAP+ astrocytes, ED1-/ED2+/RCA-1+/OX-6-perivascular cells and ED1-/ED2-/RCA-1+/lysozyme--microglia were found to have survived the procedure. Cells of the macrophage phenotype (ED1+/ED2+/RCA-1+/lysozyme+/vimentin+ with phagocytic vacuoles), however, were only found in large numbers in specimens kept within 5.0 microns pore size chambers, giving access to non-resident cells, and were exceedingly rare in specimens from 0.22-micron pore
https://www.semanticscholar.org/paper/Origin-of-macrophages-in-central-nervous-tissue-A-Stevens-B%C3%A4hr/bdd5a1a0e271e7b55b56d35a0868867655c5c0b3
Plus itPlus it
Animals and tissues. Tissues of embryonic and postnatal Lewis rats were used in this study. The day of vaginal plug detection was considered embryonic day 1 (E1). Pregnant females were decapitated, and the embryos (E14, E16, and E19) were rapidly removed, embedded in Tissue Tek (OCT compound; Zoeterwoude), and frozen in isopentane at −40°C for subsequent in situ hybridization and immunohistochemistry. Brain, spinal cord, and eyes of postnatal animals from postnatal day 0 (P0), P1, P3, P5, P9, P14, and adult animals were removed and processed as indicated above. Each developmental time point was analyzed in at least three different animals. In addition, tissues from adult decapitated animals were collected for Western and Northern blotting. For confocal microscopy, adult Lewis rats were killed with pentobarbital (500 mg/kg) and perfused transcardially with Ringers solution followed by 4% paraformaldehyde in 0.15 m phosphate buffer with 5% sucrose. The spinal cords were removed and post-fixed ...
http://www.jneurosci.org/content/22/9/3553
E-MTAB-2719 - Gene expression profiling of Bone-Marrow-Derived-Macrophages (5 days of culture) in a backcross population of LEW...
WKY and LEW strains have been widely studied for their differential susceptibility to experimental glomerulonephritis. In particular these strains show strong variations in the macrophage activation. This dataset measures expression of macrophages in backcross population of WKY DC and LEW rats and includes a few control origninating from the WKY DC strain.
https://www.omicsdi.org/dataset/arrayexpress-repository/E-MTAB-2719
IS LEW BROWN STILL ALIVE?
Is Lew Brown Dead? Lew Brown Dead or Alive? How did Lew Brown die? Get Lew Brown s Cause of Death, Birthdate, Health Status, Net Worth, and Profile! Dont Believe the Hoax!
https://isthatguystillalive.com/names/lewbrown
Moving right along
Look, mate, Im sorry, but Ive got to get going, Ive, er, got somewhere to be…. HENRY: (gently teasing) Oh?. LEW: Yeh…just out…somewhere…with a mate…. HENRY: Does this mate happen to be a pretty little butterfly?. LEW: Easy, awright? Bad enough I get it from the girls at the shop…. HENRY: Awwww, (he tousles the trilby on LEWs head, which frustrates him to no end) Widdle Lews got a lady-friend!. (LEW is frustrated, but knows hell have to deal with it sooner or later. He actually begins to smile a little until, flustered, he starts slapping HENRYs cooing and coddling away.). LEW: Awright, awright, thats enough! I really gotta go.. HENRY: Then go, you daft bug! Faint hearts and fair ladies and all that!. (he dismisses him with a wave and a smile. LEW returns the smile sheepishly. Hes new at this.). LEW: Right. Here I go.. HENRY: Yes.. LEW: Im going.. HENRY: Yes…. LEW: Out on a date…with Vera…. HENRY: Just go already!. LEW: Blimey…. (he putters off, muttering worriedly ...
http://generationextant.com/?p=1998
The Daily Lew - Issue 6 - drill baby, drill. | Watts Up With That?The Daily Lew - Issue 6 - drill baby, drill. | Watts Up With That?
LewWorld has increased its spin and is now drilling into noise. The resulting increased spin and precession looks to be creating dangerous wobble on LewWorld. Meanwhile while Lew is drilling for noise, McIntyre has tried to get the same results as Lewandowskys paper by taking Lewandowskys noisy data and applying the same techniques listed in…
https://wattsupwiththat.com/2012/09/17/the-daily-lew-issue-6-drill-baby-drill/
Ask the Expert with Lew Schon, MDAsk the Expert with Lew Schon, MD
Members brought some of their toughest cases to Dr. Lew Schon at this dynamic live event. Join us to hear his advice and the discussions that ensued for the following cases ...
https://prc.aofas.org/Public/Catalog/Details.aspx?id=2cDP0RdJowFC8d91qFVNqg%3D%3D
Sky-Green Mural - Matthew Lew| Murals Your WaySky-Green Mural - Matthew Lew| Murals Your Way
Split-frame images of clouds provide two views of the sky. And just because they are called wall murals, their use is not limited to walls. Try adding these clouds to your ceiling
https://www.muralsyourway.com/p/sky-green-mural/
Suppression of complement activation by recombinant Crry inhibits experimental autoimmune anterior uveitis (EAAU) -ORCASuppression of complement activation by recombinant Crry inhibits experimental autoimmune anterior uveitis (EAAU) -ORCA
This study was initiated to explore the effect of recombinant rat Crry linked to the Fc portion of rat IgG2a (Crry-Ig) on the induction of experimental autoimmune anterior uveitis (EAAU) and on established disease. EAAU was induced in Lewis rats by immunization with bovine melanin-associated antigen (MAA). MAA sensitized animals received Crry-Ig, rat IgG2a (isotype control) or PBS separately before the onset of EAAU or after the onset of clinical disease. Administration of Crry-Ig suppressed the induction of EAAU while all animals injected with IgG2a or PBS developed the normal course of EAAU. Treatment with Crry-Ig resulted in the suppression of ocular complement activation as well as the functional activity of complement in the peripheral blood. At the peak of EAAU, levels of IFN-γ, IP-10, ICAM-1 and LECAM-1 were significantly reduced within the eyes of Crry-Ig treated Lewis rats. Importantly, administration of Crry-Ig even after the onset of EAAU resulted in a sharp decline in the disease ...
http://orca.cf.ac.uk/18965/
Abstract 12857: The Use of Cell Sheet Technique Enhances the Therapeutic Effects of Skeletal Myoblast Transplantation with...Abstract 12857: The Use of Cell Sheet Technique Enhances the Therapeutic Effects of Skeletal Myoblast Transplantation with...
There is compelling experimental evidence to show that transplantation of skeletal myoblasts (SMBs) improves the function of failing hearts via paracrine effects. However, clinical application of this strategy has been curtailed due to arrhythmia occurrence and inconsistent outcomes observed in previous clinical trials of intramyocardial (IM) injection of SMBs. Severe inflammation and resultant global reduction of connexin43 have been reported to be causes of the arrhythmogenicity. Recent developments in bioengineering technology enabled production of cell sheets using temperature-responsive culture dishes, which allows retrieval of cells without enzymatic dissociation-related damages. We hypothesized that epicardial attachment of cell sheets would enhance retention, survival, and maintenance of functions of donor SMBs in the heart, with less myocardial injury, and therefore overcome the drawbacks of IM injection.. Methods & Results: After left coronary artery ligation in female Lewis rats, ...
http://circ.ahajournals.org/content/122/Suppl_21/A12857
Phenotypes of T cells infiltrating the eyes in autoimmune anterior uveitis associated with EAE<...Phenotypes of T cells infiltrating the eyes in autoimmune anterior uveitis associated with EAE<...
TY - JOUR. T1 - Phenotypes of T cells infiltrating the eyes in autoimmune anterior uveitis associated with EAE. AU - Zhang, Xingqi. AU - Jiang, Shuguang. AU - Manczak, Maria. AU - Sugden, Brad. AU - Adamus, Grazyna. PY - 2002. Y1 - 2002. N2 - PURPOSE. Lewis rats immunized with myelin basic protein (MBP) develop experimental autoimmune encephalomyelitis (EAE) and associated anterior uveitis (AU), which recurs. The goal was to analyze cellular activation markers and adhesion molecules of T cells that infiltrate the eyes and spinal cord during acute and recurrent AU in actively and passively induced diseases simultaneously in the same animals. METHODS. EAE-AU was induced in Lewis rats by immunization with MBP in CFA, or by adoptive transfer of MBP-specific T-cell lines, and the signs of clinical EAE and AU was scored. Cells isolated from the iris-ciliary body were tested by flow cytometry for expression of CD4, CD8, CD45RC, T-cell receptor (TCR) Vβ8.2, α4 integrin, L-selectin, CD44, and CD134. ...
https://ohsu.pure.elsevier.com/en/publications/phenotypes-of-t-cells-infiltrating-the-eyes-in-autoimmune-anterio-2
Gene transfer using artificial chromosomes containing a marker gene in primary cells and rat adjuvant arthritis | Arthritis...Gene transfer using artificial chromosomes containing a marker gene in primary cells and rat adjuvant arthritis | Arthritis...
Most antirheumatic therapies are given systemically, which may result in complications because of the high dosage needed to achieve therapeutic levels in the joints. Gene therapy might provide a more efficient system to deliver therapeutic compounds at the site of inflammation. The artificial chromosome expression system (ACes) is a unique, nonintegrating, nonviral gene-expression system, which functions like a natural chromosome. This technology offers advantages over current expression systems because it allows stable expression of genes producing single or multiple proteins over long periods. We are developing ex vivo gene therapy using artificial chromosomes containing reporter genes (LacZ or RFP) for local delivery of genes in rats with adjuvant arthritis. The aim of this study was to evaluate the transfection efficiency in cell lines or primary cells, including rat skin fibroblasts (RSFs) and fibroblast-like synoviocytes (FLSs). Furthermore, we investigated the feasibility of local ...
https://arthritis-research.biomedcentral.com/articles/10.1186/ar708
Toll-Like Receptor 2 Pathway Drives Streptococcal Cell Wall-Induced Joint Inflammation: Critical Role of Myeloid...Toll-Like Receptor 2 Pathway Drives Streptococcal Cell Wall-Induced Joint Inflammation: Critical Role of Myeloid...
The present study was performed to investigate the role of IL-1R/TLR signaling in joint inflammation induced by bacterial cell wall fragments (SCW) from S. pyogenes. To this end, we induced SCW arthritis in mice that are deficient for MyD88, the pivotal adaptor molecule in the IL-1R/TLR signaling cascade. In addition, we analyzed whether joint inflammation, elicited by local injection of SCW fragments, was mediated by TLR-2 or TLR-4. Therefore, mice deficient for either TLR-2 or TLR-4 were included in this study.. TLRs are present on several cell types, including fibroblasts, macrophages, and dendritic cells (1, 2, 3, 4, 5, 6). Recently, it was shown that synovial fibroblasts express mainly TLR-2 since fibroblasts from RA patients could be activated by TLR-2 (bacterial peptidoglycans) and not by TLR-9 (CpG motifs) agonists to produce proinflammatory cytokines and matrix metalloproteinases (41). Expression of TLR-2 and TLR-4 but not TLR-9 was found in synovial biopsies of RA patients with active ...
http://www.jimmunol.org/content/171/11/6145.long
RePub, Erasmus University Repository: No association between tumor necrosis factor-α production and gene polymorphisms among...RePub, Erasmus University Repository: No association between tumor necrosis factor-α production and gene polymorphisms among...
Differences in spontaneous allograft acceptance after liver transplantation among inbred rat strains might be explained by variation in the local production of TNF-α as a potent mediator of the inflammatory response. In this study, we hypothesize that nucleotide differences in the rat Tnf gene influence TNF-α protein expression. As such, polymorphisms in the Tnf gene may also provide a possible explanation for differences in survival of allogeneic liver grafts among inbred rat strains. We therefore investigated the capacity of mononuclear cells to produce TNF-α in response to a mitogenic stimulus and the Tnf locus was sequenced in six different inbred rat strains. Among the six strains (AUG, BN, DA, LEW, PVG and WF), 44 nucleotide differences including 36 single nucleotide polymorphisms (SNPs), five simple sequence length polymorphisms, two deletions and one insertion, were found in the Tnf gene. Although, the inbred rat strains differed significantly in mean levels of maximum TNF-α ...
https://repub.eur.nl/pub/62344
JCI - Resetting the transcription factor network reverses terminal chronic hepatic failureJCI - Resetting the transcription factor network reverses terminal chronic hepatic failure
Animals. Lewis rats were obtained from Charles River and were maintained in isolation cages in the Department of Laboratory and Animal Resources at the University of Pittsburgh. Animals were housed in temperature- and light/dark cycle-controlled rooms.. Induction of liver cirrhosis. Liver cirrhosis was induced as described previously by using phenobarbital and CCl4 (both Sigma-Aldrich) when inbred male Lewis rats, weighing 100-130 g, were 4 weeks old (16). Rats were given phenobarbital (0.5 g/l) added to the drinking water. Starting 2 weeks later, CCl4 (diluted 1:9 in olive oil) was administered by gavage twice a week. Following an initial dose of 0.2 ml/kg, each subsequent dose was adjusted weekly on the basis of changes in body weight. If body weight increased or remained unchanged, CCl4 was continued at 0.2 ml/kg twice weekly. When body weight decreased by 1-5 g, the dose of CCl4 was reduced to 0.15 ml/kg, and if body weight decreased by 6-10 g, the CCl4 was reduced to 0.1 ml/kg. In rats that ...
https://www.jci.org/articles/view/73137
JCI - DNA vaccination with CD25 protects rats from adjuvant arthritis and induces an antiergotypic responseJCI - DNA vaccination with CD25 protects rats from adjuvant arthritis and induces an antiergotypic response
Abs to the α-chain of the IL-2 receptor (anti-CD25) are used clinically to achieve immunosuppression. Here we investigated the effects of DNA vaccination with the whole CD25 gene on the induction of rat adjuvant arthritis. The DNA vaccine protected the rats and led to a shift in the cytokine profile of T cells responding to disease target antigens from Th1 to Th2. The mechanism of protection was found to involve the induction of an antiergotypic response, rather than the induction of anti-CD25 Abs. Antiergotypic T cells respond to activation molecules, ergotopes, expressed on syngeneic activated, but not resting, T cells. CD25-derived peptides function as ergotopes that can be recognized by the antiergotypic T cells. Antiergotypic T cells taken from control sick rats did not proliferate against activated T cells and secreted mainly IFN-γ. In contrast, antiergotypic cells from CD25-DNA-protected rats proliferated against activated T cells and secreted mainly IL-10. Protective antiergotypic T ...
https://www.jci.org/articles/view/17772/figure/1
FETAL BONE GRAFTS DO NOT ELICIT ALLOGRAFT REJECTION BECAUSE OF PROTECTING ANTI-Ia ALLOANTIBODIES: IMPLICATIONS TO THE IMMUNE...FETAL BONE GRAFTS DO NOT ELICIT ALLOGRAFT REJECTION BECAUSE OF PROTECTING ANTI-Ia ALLOANTIBODIES: IMPLICATIONS TO THE IMMUNE...
Summary In a previous study we showed that allografts of BN fetal bone, unlike allografts of adult bone, are not rejected by allogeneic recipients of the Lewis strain in spite of the existence of major histocompatibility complex (MHC) incompatibility between donors and hosts. In the present study,...
https://insights.ovid.com/transplantation/trans/1979/08/000/fetal-bone-grafts-not-elicit-allograft-rejection/3/00007890
Immunoregulation of Experimentally Induced Immune Responses - J. AllenImmunoregulation of Experimentally Induced Immune Responses - J. Allen
Systemic injection of streptococcal cell walls (SCW) initiates acute and chronic inflammation in liver, spleen and peripheral joints of susceptible rats. Associ...
https://grantome.com/grant/NIH/Z01-DE000441-04
Anesthesiologist Michael Lew on improvements in cancer careAnesthesiologist Michael Lew on improvements in cancer care
City of Hopes Dr. Michael Lew explains the evolving role of anesthesia in cancer treatment and how new technologies are advancing the field.
https://www.cityofhope.org/michael-lew-anesthesia-cancer/
EAN 2260540754292 Topshop Chiffon Sleeve Blouse Nude 2 (0 US)
EAN 2260540754292 Airy chiffon sleeves lend breezy warm-weather style to a smart blouse streamlined with a dainty collar and a crisp, covered placket. Color(s): , also find 2260540754292 barcode , images and shopping info of EAN 2260540754292
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Circles In The Sand 1 - Panoramic Mural - Matthew Lew| Murals Your WayCircles In The Sand 1 - Panoramic Mural - Matthew Lew| Murals Your Way
These sophisticated yet playful patterns would enhance a formal dining room wall or use around the entire perimeter. This panoramic wall mural features red, purple and gold stripes in a variety of textures.
https://www.muralsyourway.com/p/circles-in-the-sand-1-panoramic-mural/
Types of Microorganisms - Metal Contaminated - Dr. Darrin LewTypes of Microorganisms - Metal Contaminated - Dr. Darrin Lew
There are two different kinds of organisms that coexist in the contemporary living world the eukaryotes (more complex organisms with a true nucleus, which
https://www.drdarrinlew.us/metal-contaminated-2/types-of-microorganisms.html
Tritium - WikipediaTritium - Wikipedia
In a 1998 study, tritium concentrations in surface seawater and atmospheric water vapor (10 meters above the surface) were sampled at the following locations: the Sulu Sea, the Fremantle Bay, the Bay of Bengal, the Penang Bay, and the Strait of Malacca.[38] Results indicated that the tritium concentration in surface seawater was highest at the Fremantle Bay (approximately 0.40 Bq/liter), which could be accredited to the mixing of runoff of freshwater from nearby lands due to large amounts found in coastal waters.[38] Typically, lower concentrations were found between 35 and 45 degrees south latitude and near the equator. Results also indicated that (in general) tritium has decreased over the years (up to 1997) due to the physical decay of bomb tritium in the Indian Ocean. As for water vapor, the tritium concentration was approximately one order of magnitude greater than surface seawater concentrations (ranging from 0.46 to 1.15 Bq/liter).[38] Therefore, the water vapor tritium is not affected by ...
https://en.m.wikipedia.org/wiki/Tritium
1,1′ -Ethylidenebis- [tryptophan] induces pathologic alterations in muscle similar to those observed in the eosinophilia...
TY - JOUR. T1 - 1,1′ -Ethylidenebis- [tryptophan] induces pathologic alterations in muscle similar to those observed in the eosinophilia-myalgia syndrome. AU - Emslie-Smith, A. M.. AU - Mayeno, A. N.. AU - Nakano, S.. AU - Gleich, G. J.. AU - Engel, A. G.. N1 - Copyright: Copyright 2020 Elsevier B.V., All rights reserved.. PY - 1994/12. Y1 - 1994/12. N2 - l,l′-Ethylidenebis[tryptophan] (EBT), a derivative of L- tryptophan (LT), is a trace contaminant in batches of LT implicated by epidemiologic evidence in the pathogenesis of the eosinophilia-myalgia syndrome (EMS). We treated female Lewis rats with EBT or unimplicated LT (4 mg per 100 grams daily) by intraperitoneal injection. No rash or weakness occurred in either group. All three EBT rats had a few necrotic muscle fibers. In two rats, perimysium and fascia were abnormally thickened and infiltrated with lymphocytes, macrophages, and sparse eosinophils; two rats had sparse perineurial inflammatory cells. Rats treated with unimplicated LT ...
https://mayoclinic.pure.elsevier.com/en/publications/11-ethylidenebis-tryptophan-induces-pathologic-alterations-in-mus
Ultrastructure of Glomerular Basement Membrane in Active Heymann Nephritis Rats Revealed by Tissue-Negative Staining Method -...
Tissue-Negative Staining法によって明らかになったActive Heymann Nephritisラット腎糸球体基底膜の超微細構 ...
http://escholarship.lib.okayama-u.ac.jp/en/5936
Heterotopic heart transplantation: The United States experience<...Heterotopic heart transplantation: The United States experience<...
TY - JOUR. T1 - Heterotopic heart transplantation. T2 - The United States experience. AU - Jahanyar, Jama. AU - Koerner, Michael M.. AU - Ghodsizad, Ali. AU - Loebe, Matthias. AU - Noon, George P.. PY - 2014/6. Y1 - 2014/6. N2 - Introduction: More than 3 decades have passed since the first heterotopic heart transplantation (HHT) was reported. Nowadays, this surgical technique is used rarely, and only in patients who do not qualify for standard orthotopic heart transplantation (OHT). Current indications mainly comprise refractory pulmonary hypertension and a donor-recipient size mismatch (,20%). The objective of this study was to analyze the United States experience with HHT. Patients and Methods: The United Network for Organ Sharing (UNOS) database between 1987 and 2007 was analyzed. Patients who underwent heart transplantation were enrolled in this study. Patients with missing transplant dates or history of retransplantation were excluded. Results: A total of 41,379 patients underwent OHT and ...
https://scholars.houstonmethodist.org/en/publications/heterotopic-heart-transplantation-the-united-states-experience
Rat strain differences in peripheral and central serotonin transporter protein expression and functionRat strain differences in peripheral and central serotonin transporter protein expression and function
Female Fischer 344 (F344) rats have been shown to display increased serotonin transporter (5-HTT) gene expression in the dorsal raphe, compared to female Lewis (LEW) rats. Herein, we explored, by means of synaptosomal preparations and in vivo microdialysis, whether central, but also peripheral, 5-HTT protein expression/function differ between strains. Midbrain and hippocampal [3H]paroxetine binding at the 5-HTT and hippocampal [3H]serotonin (5-HT) reuptake were increased in male and female F344 rats, compared to their LEW counterparts, these strain differences being observed both in rats of commercial origin and in homebred rats. Moreover, in homebred rats, it was found that these strain differences extended to blood platelet 5-HTT protein expression and function. Saturation studies of midbrain and hippocampal [3H]paroxetine binding at the 5-HTT, and hippocampal and blood platelet [3H]5-HT reuptake, also revealed significant strain differences in Bmax and Vmax values. Although F344 and LEW rats ...
https://research-repository.griffith.edu.au/handle/10072/27590
Anti-inflammatory Effects of Aronia Extract on Rat Endotoxin-Induced Uveitis | IOVS | ARVO JournalsAnti-inflammatory Effects of Aronia Extract on Rat Endotoxin-Induced Uveitis | IOVS | ARVO Journals
purpose. Aronia crude extract (ACE) with high levels of polyphenol compounds has been reported to have antioxidative effects in vitro and in vivo. In this study, attention was focused on the antioxidant effect of ACE. The purpose of the present study was to investigate the effect of ACE on endotoxin-induced uveitis (EIU) in rats. In addition, the endotoxin-induced expression of the inducible nitric oxide synthase (iNOS) and cyclooxygenase (COX)-2 proteins was investigated in a mouse macrophage cell line (RAW 264.7) treated with ACE in vitro, to clarify the anti-inflammatory effect.. methods. EIU was induced in male Lewis rats by a footpad injection of lipopolysaccharide (LPS). Immediately after the LPS inoculation, 1, 10, or 100 mg ACE or 10 mg prednisolone was injected intravenously. After 24 hours, the aqueous humor was collected from both eyes, and the number of infiltrating cells, protein concentration, nitric oxide (NO), prostaglandin (PG)-E2, and TNF-α levels in the aqueous humor were ...
http://iovs.arvojournals.org/article.aspx?articleid=2163579
Interaction between rapamycin and pretransplant blood transfusions in rat heterotopic heart transplantation<...Interaction between rapamycin and pretransplant blood transfusions in rat heterotopic heart transplantation<...
TY - JOUR. T1 - Interaction between rapamycin and pretransplant blood transfusions in rat heterotopic heart transplantation. AU - Tucker, M. J.. AU - Duplan, J.. AU - Li, Xian Chang. AU - Garcia, B.. AU - Wijsman, J.. AU - Stiller, C.. AU - McKenzie, F. N.. PY - 1993/1/1. Y1 - 1993/1/1. UR - http://www.scopus.com/inward/record.url?scp=0027418974&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=0027418974&partnerID=8YFLogxK. M3 - Article. C2 - 8438458. AN - SCOPUS:0027418974. VL - 25. SP - 725. EP - 726. JO - Transplantation Proceedings. JF - Transplantation Proceedings. SN - 0041-1345. IS - 1. ER - ...
https://scholars.houstonmethodist.org/en/publications/interaction-between-rapamycin-and-pretransplant-blood-transfusion
Histological features and blood plasma changes after heterotopic heart transplantationHistological features and blood plasma changes after heterotopic heart transplantation
Гистологические и плазменные изменения после гетеротопической трансплантации сердцаHistological features and blood plasma changes after heterotopic heart transplantation
http://www.cttjournal.com/en/archive/tom-7-nomer-3/korotkie-soobshcheniya/gistologicheskie-i-plazmennye-izmeneniya-posle-geterotopicheskoy-transplantatsii-serdtsa/
Involvement of E-cadherin cleavage in reperfusion injury<...
TY - JOUR. T1 - Involvement of E-cadherin cleavage in reperfusion injury. AU - Goto, Taichiro. AU - Ishizaka, Akitoshi. AU - Katayama, Masahiko. AU - Kohno, Mitsutomo. AU - Tasaka, Sadatomo. AU - Fujishima, Seitaro. AU - Kobayashi, Koichi. AU - Nomori, Hiroaki. PY - 2010/2/1. Y1 - 2010/2/1. N2 - Objective: E-cadherin is a major cell-to-cell adhesion molecule, of which the ectodomain is cleaved from epithelial cells to yield a soluble form after the pathological alteration of the alveolar epithelium. We investigated the excretion level of soluble E-cadherin in a rat lung isotransplant model, and demonstrated the involvement of this molecule in the pathogenesis of reperfusion injury after lung transplantation. Methods: Inbred male Lewis rats were used as both donor and recipient animals, and they were subjected to left lung isotransplantation. After 6 h of ischaemia, the left lung was transplanted into a recipient rat and reperfused for 4 h. The animals were injected intravenously with ...
https://keio.pure.elsevier.com/en/publications/involvement-of-e-cadherin-cleavage-in-reperfusion-injury
The Dr. Rath Health Foundation
Proceddings of the Society of Experimental Biology and Medicine 1989 May;191(1):47-54 The effects of additional but nontoxic amounts of vitamin A on susceptibility to salmonella infection was studied by comparing rates of bacterial clearance and phagocytosis. Forty-eight male Lewis rats were divided into a treatment group receiving a total of 6000 units of vitamin A palmitate weekly for 5 weeks and a control group was given an equal volume of saline. After completion of the treatment regimen, one-half from each group were infected intraperitoneally with 10(5) Salmonella typhimurium; the other half received intraperitoneal injection of saline. At this time no differences in weight gain were noted and all animals were sacrificed within 2 weeks. At 72 hr after bacterial challenge, all saline-treated control animals displayed bacteremia. Cultures of liver and splenic homogenates were positive in 89 and 100% of infected control animals vs 0 and 44% for treated animals during the first week of ...
http://www4ger.dr-rath-foundation.org/NATUERLICHE_GESUNDHEIT/studien/infectious_disease/study/study13.htm
Asian Science Citation Index - Articles written by M SuganoAsian Science Citation Index - Articles written by M Sugano
Background. Chronic kidney disease (CKD) is an important risk factor for cardiovascular disease (CVD). Increased oxidative stress plays a role in the pathogenesis of CVD in CKD patients. The oral charcoal adsorbent AST-120 attenuates the progression of CKD possibly by removing uraemic toxins such as indoxyl sulfate (IS), and reduces oxidative stress. We investigated the relationship between oxidative stress and cardiac damage in CKD and its prevention by AST-120.. Methods. Male Lewis rats were administered adriamycin at 8 weeks of age, and the right kidney was removed at 12 weeks of age. From 14 weeks of age, the rats were treated daily with AST-120 (n = 8) or were untreated (control group, n = 8). At 34 weeks of age, the rats were killed and urinary and blood biochemical tests as well as cardiac histological analyses were performed.. Results. At 14 weeks of age, there were no significant differences in blood pressure, renal function (creatinine clearance: 1.54 ± 0.28 mL/min versus 1.60 ± 0.22 ...
https://scialert.net/asci/author.php?ascicat=ALL&author=M&last=Sugano
Search Results | AKJournalsSearch Results | AKJournals
Ductular reaction (DR) in bile duct ligated rats generally appears from 2nd day after biliary obstruction (BO). However, we show that increased amount of ductular profiles is evident already in 6 hours after BDL. The study aims to explain the origin of such an early DR in response to BO. Male Lewis rats were subjected to common bile duct ligation (CBDL) for 3, 6, 12 and 24 hours and sham operation. Liver samples were studied histologically, immunohistochemically (Ki67, pan-Cytokeratin /AE1 + AE3/ and OV-6) and by immunoblotting analyses. It appeared that number of ductular profiles increase in timerelated manner after BO. These ductular profiles are formed by biliary epitheliocyte-like cells; No mitotic activity was revealed. Part of hepatocytes reveals pan-Cytokeratin positivity on 12 and 24 hours after BO. Total cytokeratins content at 24 hours after CBDL was 37% higher in comparison with control data. The significant increase was observed for the cytokeratins with molecular weights: 61, 56 ...
https://akjournals.com/search?f_0=author&q_0=Ekaterine+Berishvili
Giant cell myocarditis responding to immunosuppressive therapy.
An unusual case of giant cell myocarditis presenting with cardiogenic shock that dramatically responded to conventional dose of steroids and azathioprine is reported. Cardiac recovery was rapid, complete (left ventricular ejection fraction rose to 55
http://www.biomedsearch.com/nih/Giant-cell-myocarditis-responding-to/10713027.html
In pictures: Deadly floods hit Germany and Belgium - Lew Lew MediaIn pictures: Deadly floods hit Germany and Belgium - Lew Lew Media
All latest Breaking news on Lew Lew Media. Browse The Independents complete collection of articles and commentary on Lew Lew Media. ...
https://lewlewmedia.com/in-pictures-deadly-floods-hit-germany-and-belgium/
Heterotopic Heart Transplantation in Mice | Protocol (Translated to Portuguese)Heterotopic Heart Transplantation in Mice | Protocol (Translated to Portuguese)
O rato modelo de transplante cardíaco heterotópico tem sido comprovada por muitos pesquisadores de ser um método importante para o...
https://www.jove.com/video/238/transplante-cardaco-heterotpico-em-ratos?language=Portuguese
Strain differences influence timing and magnitude of both acute and late inflammatory reactions after intratracheal...Strain differences influence timing and magnitude of both acute and late inflammatory reactions after intratracheal...
The acute pulmonary responses after exposure to sulfur and nitrogen mustards are well documented whereas the late pulmonary effects are not. With a novel focus on the immune system this paper investigate whether late phase pulmonary effects developed in rats exposed to the nitrogen mustard melphalan are linked to the acute responses and whether the reactions are genetically regulated. The DA rat strain was used to establish a lung exposure model. Five other inbred rat strains (PVG, PVG.1AV1, LEW, WF and F344) were compared within the model at selected time points. All rat strains displayed a biphasic pattern of leukocyte infiltration in the lungs, dominated by neutrophils 2 days after exposure and a second peak dominated by macrophages 29 days after exposure. The number of macrophages was higher in the DA rat compared with the other strains. The infiltration of lymphocytes in the lungs varied in both time of appearance and magnitude between strains. The quantity of collagen deposition in the ...
http://onlinelibrary.wiley.com/doi/10.1002/jat.2878/abstract?globalMessage=0
Allan Lew, MDAllan Lew, MD
Dr. Lew is an experienced Cardiologist currently with Cardiovascular Medical Group in Beverly Hills. He is an attending Cardiologist at Cedars-Sinai Medical Center and a Cerdiologist/Medical Specialist Consultant at Roybal Community Health Center in Los Angeles.. Dr. Lew has over 40 years of experience in his field. He sees many common heart-related concerns and has access to a referral network for all major cardiac procedures. Dr. Lew is an adult Cardiologist, but can screen patients 10 and over for referral to his network of professionals for follow-up. ...
https://mammothhospital.org/find-a-provider/cardiology-services/allan-lew/
Lew Green & Joe Muranyi: Together - JazzTimesLew Green & Joe Muranyi: Together - JazzTimes
If you can feel your pancreas dancing, the music is swinging. The quote comes from Bob Leary, banjoist/guitarist on this session. The visceral aspect is hard to prove, but his musical assessment is quite accurate. Cornetist Lew Green and clarinetist Joe Muranyi, who have individually accumulated many decades of touring and recording world-wide, even working as sidemen in the same bands, finally pool their Traditional talents as co-leaders, and the result is often authentic, vintage Dixieland. What gives it authenticity right at the outset, Oriental Man, is the bouncy sound of Vince Giordanos bass sax, plus the firm stride backing of pianist Jeff Barnhart. Guitarist Leary, who approaches his instrument with the same percussiveness as the banjo, also contributes a fine solo. The track has a joyous retro feel to it ...
https://jazztimes.com/reviews/albums/lew-green-joe-muranyi-together/
1lew.1 | SWISS-MODEL Template Library
SWISS-MODEL Template Library (SMTL) entry for 1lew.1. CRYSTAL STRUCTURE OF MAP KINASE P38 COMPLEXED TO THE DOCKING SITE ON ITS NUCLEAR SUBSTRATE MEF2A
https://swissmodel.expasy.org/templates/1lew
Lew s Mach Speed Stick Casting Rod | Kittery Trading PostLew s Mach Speed Stick Casting Rod | Kittery Trading Post
It all starts with the blank, which is lightweight and sensitive IM6 graphite constructed using Lew s® proprietary Carbon Nano Tube process. The blank is multi-…
http://www.kitterytradingpost.com/fishing-marine/freshwater-casting-rods-reels/lew%C2%92s-mach-speed-stick-casting-rod-103511.html?cgid=fishing-marine-freshwater-fishing-casting-rods-reels
LACOSTE BARBADOS HW2 MULTICOLOR 725LEW4006221 - Trampki 0,00 PLN - Symbiosis.com.plLACOSTE BARBADOS HW2 MULTICOLOR 725LEW4006221 - Trampki 0,00 PLN - Symbiosis.com.pl
LACOSTE BARBADOS HW2 725LEW4006221 Najwyższa jakość produktów ✅ Oficjalny dystrybutor marek ✅ Darmowa dostawa ✅ - Symbiosis - Lacoste
https://www.symbiosis.com.pl/lacoste-barbados-hw2-damskie-trampki-multicolor-725lew4006221
eam什么意思,eam的中文翻譯,eam的發音,用法和例句 - WebSaru英漢字典
eam中文意思: eam [] |希| Ethniko Apelevtherotiko Metopo(第二次世界大戰時希臘的) 民族解放陣線(=National ..., 學習eam發音, eam例句盡在WebSaru字典。
http://tw.websaru.com/eam.html
Photosynthesis - Physical, molecular and physiological processes - Jack Farineau, Jean-François Morot-Gaudry (EAN13 :...Photosynthesis - Physical, molecular and physiological processes - Jack Farineau, Jean-François Morot-Gaudry (EAN13 :...
Photosynthesis - Physical, molecular and physiological processes - Jack Farineau, Jean-François Morot-Gaudry (EAN13 : 9782759226696)
https://www.quae.com/product/1439/9782759226696/photosynthesis
San Joan bezperako gau magikoa - GaztezuloSan Joan bezperako gau magikoa - Gaztezulo
Udako solstizioa ekainaren 21ean den arren, hilaren 23an, hau da, San Joan bezperan ospatzen dugu urteko gau motzena, erlijioaren eraginez. Herri gehienetan bezala, Euskal mitologiaren arabera, gau berezia da gaurkoa.
https://www.gaztezulo.eus/albisteak/san-joan-bezperako-gau-magikoa
NEUDORFF AZET Vital Kalk 10 kg | ForLife24.comNEUDORFF AZET Vital Kalk 10 kg | ForLife24.com
Kalkstickstoff, Neudorff, Vital vom Ebay Shop. Merkmale und Zustand: Neu: Herstellernummer: 172 Geeignete Pflanzenart: Rasen Produktart: VitalKalk Marke: Neudorff EAN: 4005240001721 Neudorff Azet
https://www.forlife24.com/produkt/neudorff-azet-vital-kalk-10-kg/
List of MeSH codes (B01)List of MeSH codes (B01)
... rats, inbred f344 MeSH B01.050.157.760.275 - rats, inbred lec MeSH B01.050.157.760.280 - rats, inbred lew MeSH B01.050.157.760. ... rats, inbred f344 MeSH B01.050.199.520.760.275 - rats, inbred lec MeSH B01.050.199.520.760.280 - rats, inbred lew MeSH B01.050. ... rats, inbred aci MeSH B01.050.157.760.090 - rats, inbred bb MeSH B01.050.157.760.110 - rats, inbred bn MeSH B01.050.157.760.130 ... rats, inbred shr MeSH B01.050.157.760.360 - rats, inbred wf MeSH B01.050.157.760.390 - rats, inbred wky MeSH B01.050.199.040 - ...
https://en.wikipedia.org/wiki/List_of_MeSH_codes_(B01)
List of mammals of FloridaList of mammals of Florida
The silver rice rat is not in this list because it was reclassified as a synonym of the marsh rice rat (Oryzomys palustris). ... Pérez-Hernandez, R.; Lew, D.; Solari, S. (2016). "Didelphis virginiana". IUCN Red List of Threatened Species. 2016: e. ... "Inbreeding". State of Florida. Archived from the original on September 7, 2005. Retrieved July 19, 2007. "1980". State of ... Non-native species brought in boats by colonizers are the black rat, brown rat and house mouse. Other non-natives are the ...
https://en.wikipedia.org/wiki/List_of_mammals_of_Florida
Bronchus-associated lymphoid tissue is targeted and damaged by recipient lymphocytes in long-term-surviving rat lung allograftBronchus-associated lymphoid tissue is targeted and damaged by recipient lymphocytes in long-term-surviving rat lung allograft
Rats, Inbred BN * Rats, Inbred Lew * Transplantation, Homologous ... and damaged by recipient lymphocytes in long-term-surviving rat ...
https://pubmed.ncbi.nlm.nih.gov/9290765/
Quipazine | Semantic ScholarQuipazine | Semantic Scholar
Inbred Lewis (LEW/N) female rats develop an arthritis in response to group A streptococcal cell wall peptidoglycan ... We have recently found that susceptibility to streptococcal cell wall (SCW)-induced arthritis in Lewis (LEW/N) rats is due, in ... Wet-Dog shake behaviour in the rat: A possible quantitative model of central 5-hydroxytryptamine activity ... induced hypothalamic-pituitary-adrenal axis activation is defective in streptococcal cell wall arthritis-susceptible Lewis rats ...
https://www.semanticscholar.org/topic/Quipazine/523982
Hilltop Lab Animals, Inc. | LEW/Hla® Hilltop Lab Animals, Inc. | LEW/Hla®
supplies many research animals such as the LEW/Hla®. All research models at Hilltop labs are healthy CVF animals. ... The coat color of the rat is albino. The rat colony is an inbred colony. Animals are propagated by brother x sister mating. The ... LEW/Hla®CVF® History. The Lewis rat is a descendant of the Wistar Commercial Stock of rats. The Wistar can be traced back to ... The rat was cesarean derived in 1999 and fostered onto CVF® rats. Colony histories contain some possibility of error. This ...
http://hilltoplabs.com/public/lewis.html
DeCSDeCS
Inbred Lew Rats Inbred Lewis Rats Lew Rat Lew Rat, Inbred Lew Rats Lew Rats, Inbred Lewis Rats, Inbred Rat, Inbred Lew Rat, Lew ... Inbred Lew Rat. Inbred Lew Rats. Inbred Lewis Rats. Lew Rat. Lew Rat, Inbred. Lew Rats. Lew Rats, Inbred. Lewis Rats, Inbred. ... Rat, Inbred Lew. Rat, Lew. Rats, Inbred Lewis. Rats, Lew. Tree number(s):. B01.050.050.199.520.760.280. B01.050.150.900.649.313 ... Rats, Inbred Lew Entry term(s). Inbred Lew Rat ... Rats, Inbred Lew [B01.050.050.199.520.760.280] Rats, Inbred Lew ...
https://decs.bvsalud.org/en/ths/resource/?id=12348
Extracorporeal photochemotherapy reduces the severity of Lewis rat experimental allergic encephalomyelitis through a modulation...
Ultraviolet Rays; Rats, Inbred Lew; Time Factors; Leukocytes, Mononuclear; Photochemotherapy; Encephalomyelitis, Autoimmune, ... 2004). Extracorporeal photochemotherapy reduces the severity of Lewis rat experimental allergic encephalomyelitis through a ... Extracorporeal photochemotherapy reduces the severity of Lewis rat experimental allergic encephalomyelitis through a modulation ... 2004). Extracorporeal photochemotherapy reduces the severity of Lewis rat experimental allergic encephalomyelitis through a ...
https://boa.unimib.it/handle/10281/20325
Animal Models of HydrocephalusAnimal Models of Hydrocephalus
... while the LEW/Jms rat strain came from an inbred strain of Wistar-Lewis rats that exhibit a similar onset and pathophysiology ... The genetic models include the hydrocephalus Texas (H-Tx) rat, the LEW/Jms rat, the L1CAM mutant mouse model, the hydrocephalus ... 85. Jones, H.C., Carter, B.J. and Morel, L. (2003) Characteristics of Hydrocephalus Expression in the LEW/Jms Rat Strain with ... Congenital Hydrocephalus Revealed in the Inbred Rat, LEW/Jms. Neurosurgery, 13, 548-554. https://doi.org/10.1227/00006123- ...
https://file.scirp.org/Html/4-2080201_81347.htm
Breeding Methods - Rat Guide
The specific inbreeding of rats was primarily achieved in America. The oldest known strains of inbred rats were started by ... Another scientist at Wistar, Margaret Dean Lewis, was the initiator of the LEW (Lewis) strain which reached its 8th generation ... With rats, the safe inbreeding quotient is quite high. In laboratories a line is not even considered inbreed until the 20th ... See Logos page for linking to the Rat Guide.. Contact us here: Rat Guide Team Please note: Rat Guide email is not checked daily ...
https://ratguide.com/breeding/breeding_rats/breeding_methods.php
Pesquisa | Prevenção e Controle de CâncerPesquisa | Prevenção e Controle de Câncer
... an inbred rat strain better characterized for immunological analyses. We demonstrate that Lewis transgenic rats (Lew-TRAP) ... Finally, we demonstrate that Lew-TRAP rats could be immunized with a DNA vaccine encoding a human prostate tumor antigen ( ... We propose that this Lew-TRAP strain, and prostate tumor cell lines derived from this strain, can be used as a future prostate ... In particular, a transgenic rat autochthonous model of prostate cancer using the SV40 large T antigen expressed under a ...
https://pesquisa.bvsalud.org/controlecancer/?lang=pt&q=au:Olson,+Brian+M
Anti-arthritic actions of β-cryptoxanthin against the degradation of articular cartilage in vivo and in vitro. - The Kennedy...
Oral administration of β-cryptoxanthin (0.1-1 mg/kg) to antigen-induced arthritic rats suppressed the loss of ... Rats, Inbred Lew, Swine, Synovial Fluid ... to antigen-induced arthritic rats suppressed the loss of ...
https://www.kennedy.ox.ac.uk/publications/625485
Comparison of MRI signatures in pattern I and II multiple sclerosis models. - Department of PharmacologyComparison of MRI signatures in pattern I and II multiple sclerosis models. - Department of Pharmacology
... we compared this with our previous work in a delayed type hypersensitivity model of a pattern I type lesion in the rat brain. ... We have used a recently described focal MOG-induced EAE model of the rat brain, which recapitulates many of the hallmarks of ... Rats, Rats, Inbred Lew, Regional Blood Flow, Water ... a recently described focal MOG-induced EAE model of the rat ... we compared this with our previous work in a delayed type hypersensitivity model of a pattern I type lesion in the rat brain. ...
https://www.pharm.ox.ac.uk/publications/131152
Pretransplant induction of HSP-70 in isolated adult pig islets decreases early islet xenograft survival. - Nuffield Department...
Early graft survival was evaluated in normoglycemic Lewis rats after simultaneous, contralateral transplantation of heat- ... The heat-induced HSP-70 expression protects rat islet single cells against lysis mediated by nitric oxide (NO), reactive oxygen ... Rats, Rats, Inbred Lew, Swine, Transplantation, Heterologous ... The heat-induced HSP-70 expression protects rat islet single ... Early graft survival was evaluated in normoglycemic Lewis rats after simultaneous, contralateral transplantation of heat- ...
https://www.nds.ox.ac.uk/publications/267036
Hippocampal 5-HT1A receptor binding site densities, 5-HT1A receptor messenger ribonucleic acid abundance and serotonin levels...
Harlan Sprague Dawley and Fischer F344 rats. Lewis rats expressed significantly less hippocampal and frontal cortical 5-HT1A ... The levels of hippocampal 5-HT in Fischer F344 rats were significantly greater than levels detected in the same regions for the ... Hypothalamic 5-HT and 5-hydroxyindole acetic acid levels in Harlan Sprague-Dawley rats were higher than the same area from the ... We conclude that hippocampal 5-HT1A receptor densities and 5-HT levels in the rat parallel the the activity and responsiveness ...
https://www.neuroscience.ox.ac.uk/publications/684045
GSE80976 - Effect of thermoneutral housing on non-alcoholic fatty liver disease in mice - OmicsDI
... both on high-rat diet), where ~2700 genes exhibited differential regulation. Conclusions: We present the transcriptomic profile ... diet in PBMC gene expression was analyzed in two inbred rat strains the Wistar Kyoto(WKY) and Lewis (LEW) rat PBMCs were ... Expression data from rat peripheral blood mononuclear cells (PBMCs). Project description:The effect of cafeteria (CAF) ... However, most xenograft studies are conducted in nude mice on an in-bred BALB/c background that entails protection from diet- ...
https://www.omicsdi.org/dataset/geo/GSE80976
Intra-amniotic delivery of amniotic-derived neural stem cells in a syn by Christopher Turner, Elliot C Pennington et al."Intra-amniotic delivery of amniotic-derived neural stem cells in a syn" by Christopher Turner, Elliot C Pennington et al.
Rats, Inbred Lew, Spinal Dysraphism, Stem Cell Transplantation ...
https://knowledgeconnection.mainehealth.org/mmc/1932/
RGD Reference Report - Zinc-finger nuclease mediated disruption of Rag1 in the LEW/Ztm rat. - Rat Genome Database
RESULTS: After microinjection of Rag1 specific ZFN mRNAs in 623 zygotes of inbred LEW/Ztm rats 59 offspring were born from ... Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Poster Archive Nomenclature ... Zinc-finger nuclease mediated disruption of Rag1 in the LEW/Ztm rat.. ... Hybrid Rat Diversity Panel Phenotypes GERRC (Gene Editing Rat Resource Center) Phenotypes in Other Animal Models Animal ...
https://www.rgd.mcw.edu/rgdweb/report/reference/main.html?id=7204131
Restricted IgG1 subclass of anti-Yo antibodies in paraneoplastic cerebellar degeneration. - MRC Weatherall Institute of...
Rats, Rats, Inbred Lew, Th1 Cells, Th2 Cells ...
https://www.imm.ox.ac.uk/publications/242134
Search | Global Index MedicusSearch | Global Index Medicus
Rats, Inbred Lew , Reproducibility of Results , Time Factors , Wound Healing/physiology ... Forty adult female albino rats aged 4-6 months were used in this study. Rats were divided into two groups [20 rats each]. Group ... on miR-126 and miR-210 expressions and cardiac angiogenesis in rats with type 1 diabetes. Methods: Male Wistar rats were ... The rats were allowed to climb a 1.1-m vertical ladder with weights attached to their tails and the weights were progressively ...
https://pesquisa.bvsalud.org/gim/?lang=en&q=mh:%22Neovascularization,%20Physiologic/physiology%22
The antigenicity of serum proteins and their role in xenograft rejection. | Profiles RNS
Celli S, Kelly RH, Rao AS, Pan F, Sun H, Nalesnik M, Wakizaka Y, Fung JJ, Starzl TE, Valdivia LA. The antigenicity of serum proteins and their role in xenograft rejection. Transplant Proc. 1996 Apr; 28(2):669-70 ...
https://profiles.uchicago.edu/profiles/display/9137393
Rats, Inbred OLETF | Profiles RNS
Rats, Inbred F344. *Rats, Inbred LEC. *Rats, Inbred Lew. *Rats, Inbred OLETF ... Rats, Inbred Strains [B01.050.150.900.649.313.992.635.505.700.400]. *Rats, Inbred OLETF [B01.050.150.900.649.313.992.635. ... Inbred OLETF" by people in this website by year, and whether "Rats, Inbred OLETF" was a major or minor topic of these ... An inbred strain of Long-Evans rats that develops hyperglycemia, hyperinsulinemia, and mild obesity, mostly in males, that ...
https://profiles.jefferson.edu/display/24577
Medical Science Monitor | Effect of pyrimethamine in experimental rheumatoid arthritis. - Article abstract #201062Medical Science Monitor | Effect of pyrimethamine in experimental rheumatoid arthritis. - Article abstract #201062
Results: Data showed that i.p. injection of pyrimethamineto arthritic rats induced a significant reduction in paw edema. This ... Histopathologicalassessment showed reduced inflammatory cell infiltrate in the joints of treated rats, and tissue edemaand bone ... Treatment with PYR significantly diminished nitric oxide formation in treated rats comparedwith untreated controls. Conclusions ... CIA was inducedin Lewis rats. The intraperitoneal administration of PYR and methotrexate (MTX) were started on day 25post- ...
https://medscimonit.com/reprintOrder/index/idArt/201062
MH DELETED MN ADDED MNMH DELETED MN ADDED MN
Rats, Inbred F344 B1.50.50.157.760.200 Rats, Inbred LEC B1.50.50.157.760.275 Rats, Inbred Lew B1.50.50.157.760.280 Rats, Inbred ... Rats, Inbred ACI B1.50.50.157.760.80 Rats, Inbred BB B1.50.50.157.760.90 Rats, Inbred BN B1.50.50.157.760.110 Rats, Inbred BUF ... Inbred SHR B1.50.50.157.760.300 Rats, Inbred Strains B1.50.50.157.760 Rats, Inbred WF B1.50.50.157.760.360 Rats, Inbred WKY ... Inbred A B1.50.50.157.520.300 Mice, Inbred AKR B1.50.50.157.520.318 Mice, Inbred BALB C B1.50.50.157.520.338 Mice, Inbred C3H ...
https://decs.bvs.br/P/mnchg2016.txt
Serval - The neuroretina is a novel mineralocorticoid target: aldosterone up-regulates ion and water channels in Müller glial...Serval - The neuroretina is a novel mineralocorticoid target: aldosterone up-regulates ion and water channels in Müller glial...
... in Lewis rat retinal explants, and in retinas from aldosterone-injected eyes. We evidenced cell-specific expression of MR, GR, ...
https://serval.unil.ch/fr/notice/serval:BIB_3D6B9B80AE6F
Search | Global Index MedicusSearch | Global Index Medicus
Rats, Inbred Lew , Spleen/cytology , Time Factors , Weight Loss ... Female Lewis rats were immunised with myelin basic protein (MBP ... Rats , Rats, Sprague-Dawley , Reverse Transcriptase Polymerase Chain Reaction , Spleen/cytology , Th1 Cells/immunology , Th2 ... Th1 and Th2 cytokines responded in a similar fashion in this rat model. The expression of cytokines in splenocytes was ... Animals , Male , Female , Rats , Burns/immunology , Burns/pathology , Lipopolysaccharides/pharmacokinetics , Apoptosis , ...
https://search.bvsalud.org/gim/?lang=en&q=mh:%22Lymph%20Nodes/immunology%22
RCMV increases intimal hyperplasia by inducing inflammation, MCP-1 expression and recruitment of adventitial cells to intima |...RCMV increases intimal hyperplasia by inducing inflammation, MCP-1 expression and recruitment of adventitial cells to intima |...
Infrarenal aorta was locally infected with RCMV and transplanted from female F344 rats to male Lewis rats. Graft samples were ... In this study, we assessed the effects of acute rat CMV (RCMV) infection on vessel remodeling in transplant vasculopathy, ... Inbred male (150-170 g) Lewis rats (LEW.RT1 strain) and female Fisher rats (F344.RT1v1 strain) were used. ... Transplantations of the infrarenal rat aorta: allograft (F344/LEW rats) and isograft (LEW/LEW rats) were performed as described ...
https://herpesviridae.biomedcentral.com/articles/10.1186/2042-4280-1-7
A standardized and reproducible method to measure decision-making in mice | bioRxivA standardized and reproducible method to measure decision-making in mice | bioRxiv
Tuttle, A.H., Philip, V.M., Chesler, E.J., and Mogil, J.S. (2018). Comparing phenotypic variation between inbred and outbred ... LEW is supported by a Marie Sklodowska-Curie Actions fellowship (no. 795846). FC was supported by an EMBO long term fellowship ... Sources of noise during accumulation of evidence in unrestrained and voluntarily head-restrained rats. eLife; 4:e11308. ...
https://www.biorxiv.org/content/10.1101/2020.01.17.909838v2.full
Frontiers | Reaching Out for Inaccessible Food Is a Potential Begging Signal in Cooperating Wild-Type Norway Rats, Rattus...Frontiers | Reaching Out for Inaccessible Food Is a Potential Begging Signal in Cooperating Wild-Type Norway Rats, Rattus...
... we tested in female wild-type Norway rats if the amount of reaching performed by a food-deprived rat changes with the presence/ ... we tested in female wild-type Norway rats if the amount of reaching performed by a food-deprived rat changes with the presence/ ... Focal rats displayed significantly more reaching behaviour, both in terms of number and total duration of events, when food and ... Focal rats displayed significantly more reaching behaviour, both in terms of number and total duration of events, when food and ...
https://www.frontiersin.org/articles/10.3389/fpsyg.2021.712333/full
MH DELETED MN ADDED MN
Rats, Inbred F344 B1.50.50.157.760.200 Rats, Inbred LEC B1.50.50.157.760.275 Rats, Inbred Lew B1.50.50.157.760.280 Rats, Inbred ... Rats, Inbred ACI B1.50.50.157.760.80 Rats, Inbred BB B1.50.50.157.760.90 Rats, Inbred BN B1.50.50.157.760.110 Rats, Inbred BUF ... Inbred SHR B1.50.50.157.760.300 Rats, Inbred Strains B1.50.50.157.760 Rats, Inbred WF B1.50.50.157.760.360 Rats, Inbred WKY ... Inbred A B1.50.50.157.520.300 Mice, Inbred AKR B1.50.50.157.520.318 Mice, Inbred BALB C B1.50.50.157.520.338 Mice, Inbred C3H ...
https://decs2018.bvsalud.org/I/mnchg2016.txt
MH DELETED MN ADDED MN
Rats, Inbred F344 B1.50.50.157.760.200 Rats, Inbred LEC B1.50.50.157.760.275 Rats, Inbred Lew B1.50.50.157.760.280 Rats, Inbred ... Rats, Inbred ACI B1.50.50.157.760.80 Rats, Inbred BB B1.50.50.157.760.90 Rats, Inbred BN B1.50.50.157.760.110 Rats, Inbred BUF ... Inbred SHR B1.50.50.157.760.300 Rats, Inbred Strains B1.50.50.157.760 Rats, Inbred WF B1.50.50.157.760.360 Rats, Inbred WKY ... Inbred A B1.50.50.157.520.300 Mice, Inbred AKR B1.50.50.157.520.318 Mice, Inbred BALB C B1.50.50.157.520.338 Mice, Inbred C3H ...
https://decs2019.bvsalud.org/E/mnchg2016.txt
STRAINSF344LewisTransplantationWistarLymphocytesStrainSerotoninDescriptorRodentFocalAngiogenesisCellsGeneticallyBreedersHypothesisLaboratoryFemaleSpeciesMutantMethodsModelHigh-qualityDevelopBackLevelsStudyFunction
STRAINS5
  • Inbred lab strains are often achieved by breeding brother to sister in each generation. (ratguide.com)
  • The levels of hippocampal 5-HT in Fischer F344 rats were significantly greater than levels detected in the same regions for the other two strains. (ox.ac.uk)
  • Hypothalamic 5-HT and 5-hydroxyindole acetic acid levels in Harlan Sprague-Dawley rats were higher than the same area from the other two strains. (ox.ac.uk)
  • Housing and Maintaining Customers Unique Mouse or Rat Strains at the A.R.C. (wa.gov.au)
  • The Custom Strains department provides breeding and maintenance of customer-owned rodent strains, including inbred, hybrid, congenic and genetically modified strains. (wa.gov.au)
F3444
  • We have previously demonstrated that susceptibility of the Lewis rat to inflammatory disease, compared to the relatively resistant Fischer F344 rat, is related to a hyporesponsive hypothalamopituitary adrenal axis to inflammatory and other stress mediators. (ox.ac.uk)
  • Since 5-HT and the 5HT1A receptor are important stimulators of this axis, we have investigated the levels of 5-HT1A receptor binding sites and encoding mRNA, 5-HT and 5-hydroxyindole acetic acid in various brain regions of Lewis, Harlan Sprague Dawley and Fischer F344 rats. (ox.ac.uk)
  • Lewis rats expressed significantly less hippocampal and frontal cortical 5-HT1A receptor binding sites and mRNA than Harlan Sprague-Dawley and Fischer F344 rats. (ox.ac.uk)
  • Infrarenal aorta was locally infected with RCMV and transplanted from female F344 rats to male Lewis rats. (biomedcentral.com)
Lewis7
  • Inflammatory mediator-induced hypothalamic-pituitary-adrenal axis activation is defective in streptococcal cell wall arthritis-susceptible Lewis rats. (semanticscholar.org)
  • A central nervous system defect in biosynthesis of corticotropin-releasing hormone is associated with susceptibility to streptococcal cell wall-induced arthritis in Lewis rats. (semanticscholar.org)
  • The Lewis rat is a descendant of the Wistar Commercial Stock of rats. (hilltoplabs.com)
  • Using the Lewis rat experimental allergic encephalomyelitis (EAE) model of human multiple sclerosis (MS) we examined the effect of extracorporeal UV-A irradiation on psoralen-activated PBMC. (unimib.it)
  • Growth hormone and IGF-1 deficiency exacerbate high-fat diet-induced endothelial impairment in obese Lewis dwarf rats: implications for vascular aging. (ouhsc.edu)
  • Early graft survival was evaluated in normoglycemic Lewis rats after simultaneous, contralateral transplantation of heat-shocked islets and sham-treated islets into the renal subcapsular space of the same recipient. (ox.ac.uk)
  • We found that the pre-existing LEWzizi-specific pathology precipitated EAE-related neuroinflammation into forebrain areas, which are devoid of EAE lesions in normal Lewis rats. (biomedcentral.com)
Transplantation1
  • CONCLUSION: The Rag1 mutant rat will serve as an important model for transplantation studies. (mcw.edu)
Wistar1
  • Methods: Male Wistar rats were divided into five groups (n = 7): Control, Diabetes, Diabetes+Garlic, Diabetes+Exercise, and Diabetes+Garlic+Exercise. (bvsalud.org)
Lymphocytes2
  • Therefore, we targeted the rat Rag1 gene essential for the V(D)J recombination within the immunoglobulin production process and for the differentiation of mature B and T lymphocytes to generate an immunodeficient rat model in the LEW/Ztm strain. (mcw.edu)
  • Histological evaluation also revealed the near-complete absence of lymphocytes in spleen and lymph nodes in the immunodeficient Rag1 mutant rat. (mcw.edu)
Strain2
  • An inbred strain of rat that is used in BIOMEDICAL RESEARCH . (bvsalud.org)
  • An inbred strain of Long-Evans rats that develops hyperglycemia, hyperinsulinemia, and mild obesity, mostly in males, that resembles non-insulin-dependent diabetes mellitus in humans. (jefferson.edu)
Serotonin1
  • Hippocampal 5-HT1A receptor binding site densities, 5-HT1A receptor messenger ribonucleic acid abundance and serotonin levels parallel the activity of the hypothalamo-pituitary-adrenal axis in rats. (ox.ac.uk)
Descriptor1
  • Rats, Inbred OLETF" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (jefferson.edu)
Rodent1
  • Comparison of endothelial function, O2-* and H2O2 production, and vascular oxidative stress resistance between the longest-living rodent, the naked mole rat, and mice. (ouhsc.edu)
Focal1
  • Focal rats displayed significantly more reaching behaviour, both in terms of number and total duration of events, when food and a potentially helpful partner were present compared to when either was missing. (frontiersin.org)
Angiogenesis1
  • Objective: The present study sought to explore the effect of garlic and voluntary exercise, alone or together, on miR-126 and miR-210 expressions and cardiac angiogenesis in rats with type 1 diabetes. (bvsalud.org)
Cells6
  • Dysregulation of mitochondrial biogenesis in vascular endothelial and smooth muscle cells of aged rats. (ouhsc.edu)
  • Aging-induced dysregulation of dicer1-dependent microRNA expression impairs angiogenic capacity of rat cerebromicrovascular endothelial cells. (ouhsc.edu)
  • Caloric restriction confers persistent anti-oxidative, pro-angiogenic, and anti-inflammatory effects and promotes anti-aging miRNA expression profile in cerebromicrovascular endothelial cells of aged rats. (ouhsc.edu)
  • Resveratrol encapsulated in novel fusogenic liposomes activates Nrf2 and attenuates oxidative stress in cerebromicrovascular endothelial cells from aged rats. (ouhsc.edu)
  • The heat-induced HSP-70 expression protects rat islet single cells against lysis mediated by nitric oxide (NO), reactive oxygen, and streptozotocin. (ox.ac.uk)
  • In this study, we assessed the effects of acute rat CMV (RCMV) infection on vessel remodeling in transplant vasculopathy, focusing on allograft morphology, inflammation and contribution of adventitial cells to intimal hyperplasia. (biomedcentral.com)
Genetically1
  • One must also not breed related rats together just because of the pedigree, not all the rats from each litter are the same genetically. (ratguide.com)
Breeders1
  • Line breeding is a term that breeders use to denote a family of inbred rats that begins with a single or pair of foundation rats. (ratguide.com)
Hypothesis1
  • Our findings hence support the hypothesis that rats use reaching behaviour to signal need to social partners that can help them to obtain food. (frontiersin.org)
Laboratory1
  • Resulting frame shift mutations led to functional gene ablations in zebra fish, mice, pigs and also in laboratory rats. (mcw.edu)
Female1
  • To distinguish between these two possibilities, we tested in female wild-type Norway rats if the amount of reaching performed by a food-deprived rat changes with the presence/absence of food and a social partner. (frontiersin.org)
Species3
  • Inbreeding is used extensively in the breeding of many species and can be used either to set a positive trait or identify a potentially negative trait depending upon the choices made. (ratguide.com)
  • Different species have different degrees of inbreeding tolerance. (ratguide.com)
  • And there are situations, such as when dealing with endangered species, where close inbreeding can be disastrous. (ratguide.com)
Mutant1
  • Reduction of T cell development in Rag1 mutant rats was associated with a hypoplastic thymus that lacked follicular structures. (mcw.edu)
Methods2
  • As a hobby breeder, breeding rats to involves a combination of breeding methods. (ratguide.com)
  • The three methods used to selectively breed towards this goal are inbreeding, line breeding, and outcrossing. (ratguide.com)
Model2
  • we compared this with our previous work in a delayed type hypersensitivity model of a pattern I type lesion in the rat brain. (ox.ac.uk)
  • Deletion of the US28 rat homolgue R33 reduces the capacity of CMV to accelerate chronic rejection and TV in a rat model [ 22 ]. (biomedcentral.com)
High-quality1
  • Starting with high quality rats and using inbreeding, line breeding and occasional outcrosses will help a breeder to reach the goal of improvement in the line. (ratguide.com)
Develop1
  • Closed colonies develop qualities causing the rats to be uniquely suited to certain types of research. (hilltoplabs.com)
Back1
  • Outcrossing can be used to strengthen or add a trait to a line, but it is the inbreeding of those offspring back to the foundation line that helps it to remain true to the original definition of a line. (ratguide.com)
Levels1
  • We conclude that hippocampal 5-HT1A receptor densities and 5-HT levels in the rat parallel the the activity and responsiveness of the hypthalamopituitary-adrenal axis. (ox.ac.uk)
Study1
  • A recent study showed that adult Norway rats communicate need to a potentially helpful partner in a reciprocal food-provisioning task ( Schweinfurth and Taborsky, 2018a ). (frontiersin.org)
Function1
  • hydroxylase inhibitor HET0016 attenuates cerebrovascular inflammation, oxidative stress and improves vasomotor function in spontaneously hypertensive rats. (ouhsc.edu)