A plasmid whose presence in the cell, either extrachromosomal or integrated into the BACTERIAL CHROMOSOME, determines the "sex" of the bacterium, host chromosome mobilization, transfer via conjugation (CONJUGATION, GENETIC) of genetic material, and the formation of SEX PILI.
Isoprostanes derived from the free radical oxidation of ARACHIDONIC ACID. Although similar in structure to enzymatically synthesized prostaglandin F2alpha (DINOPROST), they occur through non-enzymatic oxidation of cell membrane lipids.
(9 alpha,11 alpha,13E,15S)-9,11,15-Trihydroxyprost-13-en-1-oic acid (PGF(1 alpha)); (5Z,9 alpha,11,alpha,13E,15S)-9,11,15-trihydroxyprosta-5,13-dien-1-oic acid (PGF(2 alpha)); (5Z,9 alpha,11 alpha,13E,15S,17Z)-9,11,15-trihydroxyprosta-5,13,17-trien-1-oic acid (PGF(3 alpha)). A family of prostaglandins that includes three of the six naturally occurring prostaglandins. All naturally occurring PGF have an alpha configuration at the 9-carbon position. They stimulate uterine and bronchial smooth muscle and are often used as oxytocics.
The compound is given by intravenous injection to do POSITRON-EMISSION TOMOGRAPHY for the assessment of cerebral and myocardial glucose metabolism in various physiological or pathological states including stroke and myocardial ischemia. It is also employed for the detection of malignant tumors including those of the brain, liver, and thyroid gland. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1162)
Multisubunit enzymes that reversibly synthesize ADENOSINE TRIPHOSPHATE. They are coupled to the transport of protons across a membrane.
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
A naturally occurring prostaglandin that has oxytocic, luteolytic, and abortifacient activities. Due to its vasocontractile properties, the compound has a variety of other biological actions.
Established cell cultures that have the potential to propagate indefinitely.
The rate dynamics in chemical or physical systems.
The parts of a macromolecule that directly participate in its specific combination with another molecule.
The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments.
Proteins, usually glycoproteins, found in the viral envelopes of a variety of viruses. They promote cell membrane fusion and thereby may function in the uptake of the virus by cells.
Endogenous substances, usually proteins, which are effective in the initiation, stimulation, or termination of the genetic transcription process.
A 16-kDa peptide hormone secreted from WHITE ADIPOCYTES. Leptin serves as a feedback signal from fat cells to the CENTRAL NERVOUS SYSTEM in regulation of food intake, energy balance, and fat storage.
The segment of LARGE INTESTINE between the CECUM and the RECTUM. It includes the ASCENDING COLON; the TRANSVERSE COLON; the DESCENDING COLON; and the SIGMOID COLON.
Pathological processes that tend eventually to become malignant. (From Dorland, 27th ed)
A potent carcinogen and neurotoxic compound. It is particularly effective in inducing colon carcinomas.
Lining of the INTESTINES, consisting of an inner EPITHELIUM, a middle LAMINA PROPRIA, and an outer MUSCULARIS MUCOSAE. In the SMALL INTESTINE, the mucosa is characterized by a series of folds and abundance of absorptive cells (ENTEROCYTES) with MICROVILLI.
Cell surface receptors for obesity factor (LEPTIN), a hormone secreted by the WHITE ADIPOCYTES. Upon leptin-receptor interaction, the signal is mediated through the JAK2/STAT3 pathway to regulate food intake, energy balance and fat storage.
Tumors or cancer of the COLON.
A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.
The enzyme catalyzing the formation of orotidine-5'-phosphoric acid (orotidylic acid) from orotic acid and 5-phosphoribosyl-1-pyrophosphate in the course of pyrimidine nucleotide biosynthesis. EC 2.4.2.10.
Orotidine-5'-phosphate carboxy-lyase. Catalyzes the decarboxylation of orotidylic acid to yield uridylic acid in the final step of the pyrimidine nucleotide biosynthesis pathway. EC 4.1.1.23.
The main structural component of the LIVER. They are specialized EPITHELIAL CELLS that are organized into interconnected plates called lobules.
The monoanhydride of carbamic acid with PHOSPHORIC ACID. It is an important intermediate metabolite and is synthesized enzymatically by CARBAMYL-PHOSPHATE SYNTHASE (AMMONIA) and CARBAMOYL-PHOSPHATE SYNTHASE (GLUTAMINE-HYDROLYZING).
A rare autosomal recessive disorder of the urea cycle. It is caused by a deficiency of the hepatic enzyme ARGINASE. Arginine is elevated in the blood and cerebrospinal fluid, and periodic HYPERAMMONEMIA may occur. Disease onset is usually in infancy or early childhood. Clinical manifestations include seizures, microcephaly, progressive mental impairment, hypotonia, ataxia, spastic diplegia, and quadriparesis. (From Hum Genet 1993 Mar;91(1):1-5; Menkes, Textbook of Child Neurology, 5th ed, p51)
Organic, monobasic acids derived from hydrocarbons by the equivalent of oxidation of a methyl group to an alcohol, aldehyde, and then acid. Fatty acids are saturated and unsaturated (FATTY ACIDS, UNSATURATED). (Grant & Hackh's Chemical Dictionary, 5th ed)
Cells in the body that store FATS, usually in the form of TRIGLYCERIDES. WHITE ADIPOCYTES are the predominant type and found mostly in the abdominal cavity and subcutaneous tissue. BROWN ADIPOCYTES are thermogenic cells that can be found in newborns of some species and hibernating mammals.
The differentiation of pre-adipocytes into mature ADIPOCYTES.
Specialized connective tissue composed of fat cells (ADIPOCYTES). It is the site of stored FATS, usually in the form of TRIGLYCERIDES. In mammals, there are two types of adipose tissue, the WHITE FAT and the BROWN FAT. Their relative distributions vary in different species with most adipose tissue being white.
A continuous cell line that is a substrain of SWISS 3T3 CELLS developed though clonal isolation. The mouse fibroblast cells undergo an adipose-like conversion as they move to a confluent and contact-inhibited state.
Deposits of ADIPOSE TISSUE throughout the body. The pattern of fat deposits in the body regions is an indicator of health status. Excess ABDOMINAL FAT increases health risks more than excess fat around the hips or thighs, therefore, WAIST-HIP RATIO is often used to determine health risks.
A double-layered fold of peritoneum that attaches the STOMACH to other organs in the ABDOMINAL CAVITY.
Porphyrins with four methyl, two vinyl, and two propionic acid side chains attached to the pyrrole rings. Protoporphyrin IX occurs in hemoglobin, myoglobin, and most of the cytochromes.
A mitochondrial enzyme found in a wide variety of cells and tissues. It is the final enzyme in the 8-enzyme biosynthetic pathway of HEME. Ferrochelatase catalyzes ferrous insertion into protoporphyrin IX to form protoheme or heme. Deficiency in this enzyme results in ERYTHROPOIETIC PROTOPORPHYRIA.
A compound produced from succinyl-CoA and GLYCINE as an intermediate in heme synthesis. It is used as a PHOTOCHEMOTHERAPY for actinic KERATOSIS.
The color-furnishing portion of hemoglobin. It is found free in tissues and as the prosthetic group in many hemeproteins.
A group of compounds containing the porphin structure, four pyrrole rings connected by methine bridges in a cyclic configuration to which a variety of side chains are attached. The nature of the side chain is indicated by a prefix, as uroporphyrin, hematoporphyrin, etc. The porphyrins, in combination with iron, form the heme component in biologically significant compounds such as hemoglobin and myoglobin.
A metallic element with atomic symbol Fe, atomic number 26, and atomic weight 55.85. It is an essential constituent of HEMOGLOBINS; CYTOCHROMES; and IRON-BINDING PROTEINS. It plays a role in cellular redox reactions and in the transport of OXYGEN.
A mixed function oxidase enzyme which during hemoglobin catabolism catalyzes the degradation of heme to ferrous iron, carbon monoxide and biliverdin in the presence of molecular oxygen and reduced NADPH. The enzyme is induced by metals, particularly cobalt. EC 1.14.99.3.
A biologic alkylating agent that exerts its cytotoxic effects by forming DNA ADDUCTS and DNA interstrand crosslinks, thereby inhibiting rapidly proliferating cells. The hydrochloride is an antineoplastic agent used to treat HODGKIN DISEASE and LYMPHOMA.
A group of alkylating agents derived from mustard gas, with the sulfur replaced by nitrogen. They were formerly used as toxicants and vesicants, but now function as antineoplastic agents. These compounds are also powerful mutagens, teratogens, immunosuppressants, and carcinogens.
The restriction of a characteristic behavior, anatomical structure or physical system, such as immune response; metabolic response, or gene or gene variant to the members of one species. It refers to that property which differentiates one species from another but it is also used for phylogenetic levels higher or lower than the species.
Either of the pair of organs occupying the cavity of the thorax that effect the aeration of the blood.
Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations or by parent x offspring matings carried out with certain restrictions. This also includes animals with a long history of closed colony breeding.
An enzyme, sometimes called GGT, with a key role in the synthesis and degradation of GLUTATHIONE; (GSH, a tripeptide that protects cells from many toxins). It catalyzes the transfer of the gamma-glutamyl moiety to an acceptor amino acid.
The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment.
A nitrosamine derivative with alkylating, carcinogenic, and mutagenic properties.
Experimentally induced tumors of the LIVER.
The production of offspring by selective mating or HYBRIDIZATION, GENETIC in animals or plants.

Long-term transplantability and morphological stability of three experimentally induced urinary bladder carcinomas in rats. (1/7889)

Three transitional cell carcinomas induced in Fischer 344 rats by a methylcholanthrene pellet or a foreign body inserted locally into the bladder have been serially transplanted in the syngeneic strain for up to 6.5 years. There have been no changes in the individual morphological characteristics of the tumors during this time. Cells cultured in vitro for varying numbers of passages reproduce regularly the morphology of each tumor when they are injected back into the animals and results from a microcytotoxicity assay for cellular immunity indicate that they retain a common, bladder tumor-specific antigen. These tumors are useful for research in turmo biology and are offered to other scientists seeking transplantable carcinomas for experimentation.  (+info)

Low resting potential and postnatal upregulation of NMDA receptors may cause Cajal-Retzius cell death. (2/7889)

Using in situ patch-clamp techniques in rat telencephalic slices, we have followed resting potential (RP) properties and the functional expression of NMDA receptors in neocortical Cajal-Retzius (CR) cells from embryonic day 18 to postnatal day 13, the time around which these cells normally disappear. We find that throughout their lives CR cells have a relatively depolarized RP (approximately -50 mV), which can be made more hyperpolarized (approximately -70 mV) by stimulation of the Na/K pump with intracellular ATP. The NMDA receptors of CR cells are subjected to intense postnatal upregulation, but their similar properties (EC50, Hill number, sensitivity to antagonists, conductance, and kinetics) throughout development suggest that their subunit composition remains relatively homogeneous. The low RP of CR cells is within a range that allows for the relief of NMDA channels from Mg2+ blockade. Our findings are consistent with the hypothesis that CR cells may degenerate and die subsequent to uncontrolled overload of intracellular Ca2+ via NMDA receptor activation by ambient glutamate. In support of this hypothesis we have obtained evidence showing the protection of CR cells via in vivo blockade of NMDA receptors with dizocilpine.  (+info)

Virulence of a spaP mutant of Streptococcus mutans in a gnotobiotic rat model. (3/7889)

Streptococcus mutans, the principal etiologic agent of dental caries in humans, possesses a variety of virulence traits that enable it to establish itself in the oral cavity and initiate disease. A 185-kDa cell surface-localized protein known variously as antigen I/II, antigen B, PAc, and P1 has been postulated to be a virulence factor in S. mutans. We showed previously that P1 expression is necessary for in vitro adherence of S. mutans to salivary agglutinin-coated hydroxyapatite as well as for fluid-phase aggregation. Since adherence of the organism is a necessary first step toward colonization of the tooth surface, we sought to determine what effect deletion of the gene for P1, spaP, has on the colonization and subsequent cariogenicity of this organism in vivo. Germ-free Fischer rats fed a diet containing 5% sucrose were infected with either S. mutans NG8 or an NG8-derived spaP mutant strain, PC3370, which had been constructed by allelic exchange mutagenesis. At 1-week intervals for 6 weeks after infection, total organisms recovered from mandibles were enumerated. At week 6, caries lesions also were scored. A significantly lower number of enamel and dentinal carious lesions was observed for the mutant-infected rats, although there was no difference between parent and mutant in the number of organisms recovered from teeth through 6 weeks postinfection. Coinfection of animals with both parent and mutant strains resulted in an increasing predominance of the mutant strain being recovered over time, suggesting that P1 is not a necessary prerequisite for colonization. These data do, however, suggest a role for P1 in the virulence of S. mutans, as reflected by a decrease in the cariogenicity of bacteria lacking this surface protein.  (+info)

Synthesis and evaluation of [18F]1-amino-3-fluorocyclobutane-1-carboxylic acid to image brain tumors. (4/7889)

We have developed a new tumor-avid amino acid, 1-amino-3-fluorocyclobutane-1-carboxylic acid (FACBC), labeled with 18F for nuclear medicine imaging. METHODS: [18F]FACBC was prepared with high specific activity (no carrier added [NCA]) and was evaluated for its potential in tumor localization. A comparative study was performed for [18F]FACBC and [18F]2-fluorodeoxyglucose (FDG) in which the uptake of each agent in 9L gliosarcoma (implanted intracerebrally in Fisher 344 rats) was measured. In addition, the first human PET study of [18F]FACBC was performed on a patient with residual glioblastoma multiforme. Quantitative brain images of the patient were obtained by using a Siemens 921 47-slice PET imaging system. RESULTS: In the rat brain, the initial level of radioactivity accumulation after injection of [18F]FACBC was low (0.11 percentage injected dose per gram [%ID/g]) at 5 min and increased slightly to 0.26 %ID/g at 60 min. The tumor uptake exhibited a maximum at 60 min (1.72 %ID/g), resulting in a tumor-to-brain ratio increase of 5.58 at 5 min to 6.61 at 60 min. In the patient, the uptake of [18F]FACBC in the tumor exhibited a maximum concentration of 146 nCi/mL at 35 min after injection. The uptake of radioactivity in the normal brain tissue was low, 21 nCi/mL at 15 min after injection, and gradually increased to 29 nCi/mL at 60 min after injection. The ratio of tumor to normal tissue was 6 at 20 min after injection. The [18F]FACBC PET scan showed intense uptake in the left frontal region of the brain. CONCLUSION: The amino acid FACBC can be radiofluorinated for clinical use. [18F]FACBC is a potential PET tracer for tumor imaging.  (+info)

An intramembrane modulator of the ErbB2 receptor tyrosine kinase that potentiates neuregulin signaling. (5/7889)

The ErbB2 receptor tyrosine kinase plays a critical role in a variety of developmental processes, and its aberrant activation may contribute to the progression of some breast and ovarian tumors. ASGP2, a transmembrane glycoprotein found on the surface of the highly metastatic ascites 13762 rat mammary adenocarcinoma cell line, is constitutively associated with ErbB2 in these cells and in mammary tissue from pregnant rats. Expression studies indicate that ASGP2 interacts directly and specifically with ErbB2 through one of its epidermal growth factor-like domains and that the co-expression of the two proteins in the same cell dramatically facilitates their direct stable interaction. Ectopic expression of ASGP2 in human melanoma tumor cells potentiates the response of endogenous ErbB2 to the neuregulin-1 growth factor. These observations point to a novel intramembrane mechanism for the modulation of receptor tyrosine kinase activity.  (+info)

In vivo modulation of alternative pathways of P-450-catalyzed cyclophosphamide metabolism: impact on pharmacokinetics and antitumor activity. (6/7889)

The widely used anticancer prodrug cyclophosphamide (CPA) is activated in liver by a 4-hydroxylation reaction primarily catalyzed by cytochrome P-4502B and P-4502C enzymes. An alternative metabolic pathway involves CPA N-dechloroethylation to yield chloroacetaldehyde (CA), a P-4503A-catalyzed deactivation/neurotoxication reaction. The in vivo modulation of these alternative, competing pathways of P-450 metabolism was investigated in pharmacokinetic studies carried out in the rat model. Peak plasma concentrations (Cmax) for 4-OH-CPA and CA were increased by 3- to 4-fold, and apparent plasma half-lives of both metabolites were correspondingly shortened in rats pretreated with phenobarbital (PB), an inducer of P-4502B and P-4503A enzymes. However, PB had no net impact on the extent of drug activation or its partitioning between these alternative metabolic pathways, as judged from AUC values (area-under-the-plasma concentration x time curve) for 4-OH-CPA and CA. The P-4503A inhibitor troleandomycin (TAO) decreased plasma Cmax and AUC of CA (80-85% decrease) without changing the Cmax or AUC of 4-OH-CPA in uninduced rats. In PB-induced rats, TAO decreased AUCCA by 73%, whereas it increased AUC4-OH-CPA by 93%. TAO thus selectively suppresses CPA N-dechloroethylation, thereby increasing the availability of drug for P-450 activation via 4-hydroxylation. By contrast, dexamethasone, a P-4503A inducer and antiemetic widely used in patients with cancer, stimulated large, undesirable increases in the Cmax and AUC of CA (8- and 4-fold, respectively) while reducing the AUC of the 4-hydroxylation pathway by approximately 60%. Tumor excision/in vitro colony formation and tumor growth delay assays using an in vivo 9L gliosarcoma solid tumor model revealed that TAO suppression of CPA N-dechloroethylation could be achieved without compromising the antitumor effect of CPA. The combination of PB with TAO did not, however, enhance the antitumor activity of CPA, despite the approximately 2-fold increase in AUC4-OH-CPA, suggesting that other PB-inducible activities, such as aldehyde dehydrogenase, may counter this increase through enhanced deactivation of the 4-hydroxy metabolite. Together, these studies demonstrate that the P-4503A inhibitor TAO can be used to effectively modulate CPA metabolism and pharmacokinetics in vivo in a manner that decreases the formation of toxic metabolites that do not contribute to antitumor activity.  (+info)

Age-related reductions in [3H]WIN 35,428 binding to the dopamine transporter in nigrostriatal and mesolimbic brain regions of the fischer 344 rat. (7/7889)

In the present study, we used the potent cocaine analog [3H]WIN 35, 428 to map and quantify binding to the dopamine transporter (DAT) within the dorsal striatum, nucleus accumbens, substantia nigra, and ventral tegmental area in young (6-month-old), middle-aged (12-month-old), and aged (18- and 24-month-old) Fischer 344 rats. Quantitative autoradiographic analysis of indirect [3H]WIN 35,428 saturation curves revealed two-site binding for all four brain regions in every age group. The percentage of binding to the high- or low-affinity sites did not differ with age or region and was approximately 50%. However, significant age-related decreases in the overall density (Bmax) of [3H]WIN 35,428-binding sites were observed in the striatum, nucleus accumbens, substantia nigra, and ventral tegmental area. The Bmax within all brain regions declined by more than 15% every 6 months, with the Bmax in the aged (24-month-old) group being approximately half that measured in the young adult (6-month-old) group. Competition experiments indicated that nomifensine also exhibited two-site binding to the DAT in Fischer 344 rats. No consistent age-related differences in binding affinities were noted with either [3H]WIN 35,428 or nomifensine. Taken together, these results support the hypothesis that functional DATs within the nigrostriatal and mesolimbic systems are down-regulated with age, without changing their affinity for ligands.  (+info)

Isolation and characterization of a rat homologue of the human tuberous sclerosis 1 gene (Tsc1) and analysis of its mutations in rat renal carcinomas. (8/7889)

In the Eker rat, a germ-line mutation in the homologue of the human tuberous sclerosis gene (Tsc2) causes renal cell carcinomas (RCs) with a complete penetrance in all heterozygotes. Tsc2 mutations have also been found in a subset of chemically induced non-Eker rat RCs. Because tuberous sclerosis patients with alteration of either of the two predisposing genes (TSC1 and TSC2) show identical symptoms, the products of these two genes are thought to be involved in a common biological pathway. In this study, to analyze the possible overlap between the functions of Tsc2 and Tscl gene products, we isolated and characterized a rat homologue of the TSC1 gene (Tsc1). The rat Tsc1 gene, which has an identical exon-intron structure to that of human TSC1 and is localized on rat chromosome 3, has been shown to encode a protein (hamartin) that is highly homologous to the human counterpart with an approximately 86% amino acid sequence identity. Using PCR-single-strand conformational polymorphism analysis, we identified two splicing donor site mutations in one chemically induced rat RC (1 of 15). This suggests that alterations of the Tsc1 gene may be involved in the development of a subset of rat RCs.  (+info)

Four different groups of male Fisher rats were placed on one of the following diets for a period of one month: normal (control) diet, high cholesterol (HC) diet, high saturated fat (HF) diet and low fat (LF) diet. Subsequently, blood samples were dra
for toxicological evaluation and was selected for immunotoxicity studies by the chemical manager. Thus, the purpose of these studies was to determine the effect of diethanolamine on the immune system.. The studies were conducted in two rodent species, the female Fischer 344 rat and the female B6C3F1 mouse. Studies on the mouse are presented in this report and the studies conducted in the rat are provided under a separate report. In the studies reported here, female B6C3F1 mice were administered diethanolamine daily for 14 days at doses of 100, 300 and 600 mg/kg. Diethanolamine was administered by gavage as a solution in sterile distilled water.. The baseline toxicology studies are summarized in Table ES-1. Mice exposed to diethanolamine at doses up to and including 600 mg/kg did not have significant decreases in body weight or body weight changes when evaluated over the two week exposure period. While the thymus, spleen, and kidney were unaffected by the diethanolamine exposure, the liver (42%) ...
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The distribution, metabolism, and clearance of trimethylolpropane phosphate (TMPP), a potent, bicyclophosphate, γ-aminobutyric acid-ergic convulsant, were studied in male Fischer-344 rats. Intraperitoneal administration of TMPP was compared with oral gavage with respect to rates of absorption, distribution, and clearance. Distribution of TMPP to major body tissues was evaluated for the first 24 hr after administration or, in the case of regional brain distribution, immediately after the first TMPP-induced clinical seizure. Samples purified from the urine, feces, and bile of rats exposed to TMPP, as well as from rat liver microsomes incubated with TMPP in vitro, were analyzed for possible phase I and phase II metabolism, using HPLC. The disposition and clearance of TMPP in the blood and major body tissues were measured. TMPP was found to be well distributed to highly vascularized tissue compartments, with little retention ,24 hr after administration. TMPP was eliminated through the urine and ...
Fedders Continued: A3Q08F2B A3Q08F2B-B A3Q08F2BG A3Q08F2BG-D A3Q08F2BG-E A3Q08F2BG-F A3Q08F2CG A3Q08F2CG-A A3Q08F2CG-B A3Q08F2CG-C A3Q08F2CG-D A3Q08F2CG-E A3Q08F2CG-F A3Q08F2CG-G A3Q08F2CG-H A3Q08F2CG-J A3Q08F2CG-K A3Q08F2CG-L A3Q08F2CG-M A3Q08F2CG-N A3Q08F2CG-P A3Q08F2CG-Q A3Q08F2CG-R A3Q08F2CG-S A3Q08F2CG-T A3Q08F2CG-U A3Q08F2CG-V A3Q08F2CG-W A3Q08F2CG-X A3Q08F2D-D A3Q08F2D-E A3Q08F2E-A A3Q08F2E-C A3QO8F2CG A3X08F2A-B A3X08F2A-C A6Q08F2A-A A6X08F2A*C A6X08F2A*D A6X08F2A-A A6X08F2A-B A7Q06F2A-A A7Q08F2A*E A7Q08F2A-A A7Q08F2A-AX A7Q08F2A-BX Air Temp: B2A08F2A-J B2Q08F2A-E B2Q08F2A-F B2Q08F2A-G B2Q08F2A-H B3Q08F2A B3Q08F2A-B B3Q08F2A-C B3Q08F2A-D B3Q08F2A-E B3Q08F2A-F B3Q08F2A-G B3Q08F2A-H B3Q08F2B B3Q08F2B-A B3Q08F2B-B B3Q08F2B-D B3Q08F2B-E B3Q08F2B-F B3Q08F2B-G B3Q08F2BG-F B3Q08F2BG-G B3Q08F2B-H B3Q08F2B-J B3Q08F2B-K B3Q08F2B-L B3Q08F2B-M B3Q08F2B-N B3Q08F2B-P B3Q08F2B-Q B3Q08F2B-R B3Q08F2B-S B3Q08F2B-T B3Q08F2B-U B6X08F2A*A B7Q06F2A-A B7Q08F2A-A C3Q08F2A Comfort-aire: CS-81A-B Hampton Bay: ...
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10F200, 10F202, 10F204, 10F206, 10F220, 10F222, 10F320, 10F322, 10LF320, 10LF322, 12C508, 12C508A, 12C509, 12C509A, 12C671, 12C672, 12CE518, 12CE519, 12CE673, 12CE674, 12F1571, 12F1572, 12F1612, 12F1822, 12F1840, 12F508, 12F509, 12F510, 12F609, 12F615, 12F617, 12F629, 12F635, 12F675, 12F683, 12HV609, 12HV615, 12LF1571, 12LF1572, 12LF1612, 12LF1822, 12LF1840, 16C716, 16C717, 16C72, 16C72A, 16C73, 16C73A, 16C73B, 16C74, 16C74A, 16C74B, 16C76, 16C77, 16C770, 16C771, 16C773, 16C774, 16C84, 16C923, 16C924, 16CR72, 16CR83, 16CR84, 16F1454, 16F1455, 16F1459, 16F1503, 16F1507, 16F1508, 16F1509, 16F1613, 16F1614, 16F1615, 16F1618, 16F1619, 16F1764, 16F1765, 16F1768, 16F1769, 16F1784, 16F1786, 16F1787, 16F1788, 16F1789, 16F1823, 16F1824, 16F1825, 16F1826, 16F1827, 16F1828, 16F1829, 16F18313, 16F18323, 16F18324, 16F18325, 16F18344, 16F18345, 16F1847, 16F18854, 16F18855, 16F18856, 16F18857, 16F18875, 16F18876, 16F18877, 16F1933, 16F1934, 16F1936, 16F1937, 16F1938, 16F1939, 16F1946, 16F1947, 16F505, 16F506, ...
PIC12F1501, PIC12F1571, PIC12F1572, PIC12F1612, PIC12F1822, PIC12F1840, PIC12LF1501, PIC12LF1552, PIC12LF1571 PIC12LF1572, PIC12LF1612, PIC12LF1822, PIC12LF1840, PIC12LF1840T39A, PIC12LF1840T48A, PIC16F1454, PIC16F1455 PIC16F1459, PIC16F1503, PIC16F1507, PIC16F1508, PIC16F1509, PIC16F1512, PIC16F1513, PIC16F1516, PIC16F1517 PIC16F1518, PIC16F1519, PIC16F1526, PIC16F1527, PIC16F15325, PIC16F15345, PIC16F15354, PIC16F15355, PIC16F15356 PIC16F15375, PIC16F15376, PIC16F15385, PIC16F15386, PIC16F1574, PIC16F1575, PIC16F1578, PIC16F1579, PIC16F1613 PIC16F1614, PIC16F1615, PIC16F1618, PIC16F1619, PIC16F1703, PIC16F1704, PIC16F1705, PIC16F1707, PIC16F1708 PIC16F1709, PIC16F1713, PIC16F1716, PIC16F1717, PIC16F1718, PIC16F1719, PIC16F1764, PIC16F1765, PIC16F1768 PIC16F1769, PIC16F1773, PIC16F1776, PIC16F1777, PIC16F1778, PIC16F1779, PIC16F1782, PIC16F1783, PIC16F1784 PIC16F1786, PIC16F1787, PIC16F1788, PIC16F1789, PIC16F1823, PIC16F1824, PIC16F1825, PIC16F1826, PIC16F1827 PIC16F1828, PIC16F1829, ...
PIC12F1501, PIC12F1571, PIC12F1572, PIC12F1612, PIC12F1822, PIC12F1840, PIC12LF1501, PIC12LF1552, PIC12LF1571 PIC12LF1572, PIC12LF1612, PIC12LF1822, PIC12LF1840, PIC12LF1840T39A, PIC12LF1840T48A, PIC16F1454, PIC16F1455 PIC16F1459, PIC16F1503, PIC16F1507, PIC16F1508, PIC16F1509, PIC16F1512, PIC16F1513, PIC16F1516, PIC16F1517 PIC16F1518, PIC16F1519, PIC16F1526, PIC16F1527, PIC16F15325, PIC16F15345, PIC16F15354, PIC16F15355, PIC16F15356 PIC16F15375, PIC16F15376, PIC16F15385, PIC16F15386, PIC16F1574, PIC16F1575, PIC16F1578, PIC16F1579, PIC16F1613 PIC16F1614, PIC16F1615, PIC16F1618, PIC16F1619, PIC16F1703, PIC16F1704, PIC16F1705, PIC16F1707, PIC16F1708 PIC16F1709, PIC16F1713, PIC16F1716, PIC16F1717, PIC16F1718, PIC16F1719, PIC16F1764, PIC16F1765, PIC16F1768 PIC16F1769, PIC16F1773, PIC16F1776, PIC16F1777, PIC16F1778, PIC16F1779, PIC16F1782, PIC16F1783, PIC16F1784 PIC16F1786, PIC16F1787, PIC16F1788, PIC16F1789, PIC16F1823, PIC16F1824, PIC16F1825, PIC16F1826, PIC16F1827 PIC16F1828, PIC16F1829, ...
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Hello, Im wondering if anyone has any advice. I am taking my boy to an exotic vet tomorrow at 11 for a diagnosis. Over the past week my boy has lost...
C Regenerate\sconfig.h.in\susing\sautoheader\n D 2014-03-17T21:54:55 F .gitattributes 79e2dc99803b1937516003f4728ed60414a4066d F AUTHORS 3ae7bf63dab0930474237330b2fb32e072dfa646 F COPYING c1821e21e07982048b207657912ebebf1927b7a3 F ChangeLog 2522bfd3d9855b9960120aee38eb2335d5b69660 F Makefile.am 552bf072e7fec3596b70247406e9193e71eb62e7 F NEWS da39a3ee5e6b4b0d3255bfef95601890afd80709 F README cd868e87e1936939358cd00e69f069220d3b8c3f F SCENARIO 704bad2f7fe7ae14876aa24ca029f402363720ed F TODO b69b346f759254b82d2411a79b7ab137d01b82a5 F autogen.sh 8923c07aedf23d5fd0f33f13493f3fd8962e2543 x F aux/tcltags f7acdd7bce75011bb6502b638ca78d67d4c1500b x F aux/vimtags 3390267426aafa4615b30ba4b2ee8e0a7a0c07d3 x F config.h.in bb67bb54363c4060095d890189bbb072d34e81cd F configure.ac d1e0c2eb7849741f6961b9fe2f58b2264cdaca49 F pkgIndex.tcl.in ebbb8f66db03fa3376209ee3726f20db2fcfe447 F sample.tclshrc d65998f0e16f98aa5cadbfb8e2286839d2c45d7e F tclreadline.c 8e0b5f7ca4743c3d4e34d71aab1a69bc00d6e42b F tclreadline.h.in ...
Mjölkens förmåga att koagulera är avgörande för tillverkning av ost. Vi har tidigare visat en hög förekomst av icke-koagulerande mjölk från SRB och identifierat mjölkproteiner som potentiella markörer för denna oönskade egenskap. Inom detta projekt kommer vi att öka förståelsen för mjölkproteiners funktionalitet genom att bestämma de exakta aminosyrasekvenserna och variationerna av kaseinvarianterna. Denna information är idag inte tillgänglig på grund av brister i analysmetoder. Projektet kommer därför att ge en unik position för att bidra till en gemensam världsomfattande förståelse av mjölkproteiners funktionalitet och förekomsten av icke-koagulerande mjölk. Detta är viktigt för industriella tillämpningar inom mejeri- och avelssektorn för att förhindra förekomsten av icke-koagulerande mjölk, men också för selektion av mjölk för specifik användning och hälsoeffekter. Detta säkerställer ökad tillväxt och en lönsam och hållbar produktion för svenska
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4.54 are you f*cking kidding me? 4.54 are you f*cking kidding me? 4.54 are you f*cking kidding me? 4.54 are you f*cking kidding me? 4.54 are you f*cking kidding me? 4.54 are you f*cking kidding me? 4.54 are you f*cking kidding me? 4.54 are you f*cking kidding me? 4.54 are you f*cking kidding me? 4.54 are you f*cking kidding me? 4.54 are you f*cking kidding me? 4.54 are you f*cking kidding me? 4.54 are you f*cking kidding me? 4.54 are you f*cking kidding me? 4.54 are you f*cking kidding me?4.54 are you f*cking kidding me? 4.54 are you f*cking kidding me? 4.54 are you f*cking kidding me? 4.54 are you f*cking kidding me? 4.54 are you f*cking kidding me? 4.54 are you f*cking kidding me? 4.54 are you f*cking kidding me? 4.54 are you f*cking kidding me? 4.54 are you f*cking kidding me? 4.54 are 4.54 are you f*cking kidding me? 4.54 are you f*cking kidding me? 4.54 are you f*cking kidding me? 4.54 are you f*cking kidding me? 4.54 are you f*cking kidding me? 4.54 are you f*cking kidding me? 4.54 are you ...
Test your Fischer Projections skills with this short quiz including questions on Chirality and stereochemistry, conversion of Fischer to Newman, Sawhorse and 5/6 membered sugar rings.
Test your Fischer Projections skills with this short quiz including questions on Chirality and stereochemistry, conversion of Fischer to Newman, Sawhorse and 5/6 membered sugar rings.
Archbold Names Fischer Senior Vice President of Operations Monday, April 30, 2012 Archbold Memorial Hospital has named John Fischer as Senior Vice Pre...
F.S. Criterion 3F, HB boring head w/ r, 8 shank Barely used, particularly for you manual mill guys to have the ability to cut a groove on an ID and more ...
clear unnecessary key bindings bind[] = Mod+F1 bind[] = Mod+F2 bind[] = Mod+F3 bind[] = Mod+F4 bind[] = Mod+F5 bind[] = Mod+F6 bind[] = Mod+F7 bind[] = Mod+F8 bind[] = Mod+F9 bind[] = Mod+F10 bind[] = Mod+F11 bind[] = Mod+F12 bind[] = Mod+Shift+F1 bind[] = Mod+Shift+F2 bind[] = Mod+Shift+F3 bind[] = Mod+Shift+F4 bind[] = Mod+Shift+F5 bind[] = Mod+Shift+F6 bind[] = Mod+Shift+F7 bind[] = Mod+Shift+F8 bind[] = Mod+Shift+F9 bind[] = Mod+Shift+F10 bind[] = Mod+Shift+F11 bind[] = Mod+Shift+ ...
AC Bscale(2.0) Dscale(2.0) enhenced_level(0) isOutdoor(0) result(1) FM0 FC000000001:zzzzzz014 de 00 0 05f040045042c1040 c30 d71e9 55 027113c25d 0 0 0 0 0 0 0 025d814b71f5 05d 024c81607209 05e 023b815e71f5 0 c 022a816571f9 075 0219815271db 05e 0208812f71a4 05e 0229810d7176 05e 022f813671b4 05e 0235813f71be 05e 023b814d71d3 05e 0241814a71d9 05e 0247815671ee 05d 024d815f71fc 05d 02538169720e 05d 0259816c7212 05d 025f816b720e 05d 0265816e720c 05e 026b8170720b 05e 0265816b7202 05e 0265815b71f1 05e ...
Sammlung europäischer Schmetterlinge. IV. Noctuae - Eulen (Dritte Band) Samml. eur. Schmett. [4] : 155-194, : pl. 1-74, f. 1-345 (1800-1803), : pl. 75-86, f. 346-405 (1803-1808), : pl. 87-96, f. 406-455 (1808-1809), : pl. 97-134, f. 456-615 (1809-1813), : pl. 135-139, f. 616-638 (1814-1817), : pl. 140-141, f. 639-647 (1818-1819), : pl. 142-150, f. 648-697 (1819-1822), : pl. 151, f. 698-703 (1823), : pl. 152-156, f. 704-732 (1823-1824), : pl. 157, f. 733-736 (1825-1826), : pl. 158-160, f. 737-752 (1827-1828), : pl. 161-162, f. 753-765 (1828-1830), : pl. 163-169, f. 766-802 (1828-1832), : pl. 170-171, f. 803-812 (1832-1833), : pl. 172-176, f. 813-839 (1834), : pl. 177-179, f. 840-853 (1834-1835), : pl. 180, f. 854-858 (1834-1835), : pl. 181, f. 859-863 (1836), : pl. 182, f. 864-868 (1836-1838), : pl. 183, f. 869-873 (1837-1838), : pl. 184-185, f. 874-882 (1838), : [7], 8-24 (1834 ...
Sammlung europ ischer Schmetterlinge. IV. Noctuae - Eulen (Dritte Band) Samml. eur. Schmett. [4] : 155-194, : pl. 1-74, f. 1-345 (1800-1803), : pl. 75-86, f. 346-405 (1803-1808), : pl. 87-96, f. 406-455 (1808-1809), : pl. 97-134, f. 456-615 (1809-1813), : pl. 135-139, f. 616-638 (1814-1817), : pl. 140-141, f. 639-647 (1818-1819), : pl. 142-150, f. 648-697 (1819-1822), : pl. 151, f. 698-703 (1823), : pl. 152-156, f. 704-732 (1823-1824), : pl. 157, f. 733-736 (1825-1826), : pl. 158-160, f. 737-752 (1827-1828), : pl. 161-162, f. 753-765 (1828-1830), : pl. 163-169, f. 766-802 (1828-1832), : pl. 170-171, f. 803-812 (1832-1833), : pl. 172-176, f. 813-839 (1834), : pl. 177-179, f. 840-853 (1834-1835), : pl. 180, f. 854-858 (1834-1835), : pl. 181, f. 859-863 (1836), : pl. 182, f. 864-868 (1836-1838), : pl. 183, f. 869-873 (1837-1838), : pl. 184-185, f. 874-882 (1838), : [7], 8-24 (1834 ...
This is a female F to female F coupler inserted into a module that snaps into any of our standard keystone wall plates or surface mount housings. Use this to connect your standard TV/VCR/CATV inputs to a wall outlet for a clean look. White base with Metal F coax connector ...
QATSICPP Newsletter - November 2020 Edition. a:2:{i:0;s:0:;s:32:223c53dd10c1bc9f8d0ba12ce0fb1f61;s:13375:.blog-shortcode.archive-223c53dd10c1bc9f8d0ba12ce0fb1f61.dividers-on.classic-layout-list article { margin-top: ; padding-top: 0; border-color: ; } .blog-shortcode.archive-223c53dd10c1bc9f8d0ba12ce0fb1f61.dividers-on.classic-layout-list article:first-of-type { margin-top: 0; padding-top: 0; } .blog-shortcode.archive-223c53dd10c1bc9f8d0ba12ce0fb1f61.classic-layout-list.mode-list .post-thumbnail-wrap { width: ; } .blog-shortcode.archive-223c53dd10c1bc9f8d0ba12ce0fb1f61.classic-layout-list.mode-list .post-entry-content { width: calc(100% - ); } .blog-shortcode.archive-223c53dd10c1bc9f8d0ba12ce0fb1f61.classic-layout-list.mode-list .no-img .post-entry-content { width: 100%; } .blog-shortcode.archive-223c53dd10c1bc9f8d0ba12ce0fb1f61 .filter a, .blog-shortcode.archive-223c53dd10c1bc9f8d0ba12ce0fb1f61 .filter a * { color: #777777; } .blog-shortcode.archive-223c53dd10c1bc9f8d0ba12ce0fb1f61 ...
Fischer Chemic Ltd. Fundamental Company Report provides a complete overview of the companys affairs. All available data is presented in a comprehensive
The fischer bit assortment impresses users with its high quality, perfect fit, and low wear. A number of internal drives are available in various profile sizes and lengths. In addition, several practical bit sets are available.
7,444 Added | 27 Magazines | 4 Likes | 22 Following | 526 Followers | @tanfish7 | Keep up with Tanya Fischer on Flipboard, a place to see the stories, photos, and updates that matter to you. Flipboard creates a personalized magazine full of everything, from world news to lifes great moments. Download Flipboard for free and search for
SYMMETRICAL BANDPASS FILTERS:. Fc Type Part Number Nom. B.W. Max. B.W. Case Style ----- ----------- ------------ ---------- --------- ---------- 142 F142Y-15 526-9566-001 1.5 @ 6 dB 3.75 Y-3 200 F200A-10/30 526-9098-000 1.0 @ 6 dB 3.00 (Special 3.0 @ 6 dB 6.90 Dual) 200 F200L-10 526-9409-000 1.0 @ 6 dB 3.0 K (special) 200 F200L-10A 526-9520-001 1.0 @ 6 dB 3.0 K (special) 200 F200Y-23 526-9567-001 2.0 @ 3 dB 4.8 Y-2.8 200 F200Y-60 526-9487-000 6.0 @ 6 dB 13.0 Y (long) 205 F205Y-23 526-9568-001 2.0 @ 3 dB 4.8 Y-2.8 235 F235F-80R 526-9557-001 8.0 @ 3 dB 20.0 (@40dB) F 245.0 F245Q-1 526-9345-000 0.5 @ 3 dB 1.5 (@50dB) H (special) 245.5 F245Q-2 526-9346-000 0.5 @ 3 dB 1.5 (@50dB) H (special) 250 F250Q-1 526-9347-000 0.5 @ 3 dB 1.5 (@50dB) H (special) 250 F250Q-07 526-9484-000 0.7 @ 6 dB 2.5 H (special) 250 F250A-20 526-9012-00 2.0 @ 6 dB 4.3 C 250 F250C-27 526-9514-001 2.7 @ 6 dB 4.5 (@40dB) C 250 F250Z-3 526-9080-000 2.7 @ 6 dB 4.5 (@40dB) K (special) 250 F250X-4 526-9218-000 2.85 @ 3 dB 6.0 (@65dB) ...
08 03 94 11 FE 0B 3E 96 00 00 12 69 03 00 00 3F 04 40 04 41 04 42 04 3C 32 B0 00 00 06 05 00 00 06 04 02 6B 05 00 00 23 FE 00 00 00 00 FE 00 00 06 05 02 6C 05 00 00 2D 01 00 05 05 00 00 06 05 FE FF 08 03 94 11 FE 00 00 06 00 FE 11 00 00 00 FE 04 12 9F 04 00 00 3F 03 40 84 41 84 42 84 3C 32 B5 12 9E 04 00 00 3F 84 40 84 41 03 42 84 3C 32 B5 12 9D 04 00 00 3F 84 40 84 41 84 42 03 3C 32 B5 12 6A 04 00 00 3F 84 40 03 41 84 42 84 3C 32 B5 FE 0B 03 3C 31 FE 04 12 9F 04 00 00 3F 03 40 84 41 84 42 84 3C 32 B5 12 9E 04 00 00 3F 84 40 84 41 03 42 84 3C 32 B5 12 9D 04 00 00 3F 84 40 84 41 84 42 03 3C 32 B5 12 6A 04 00 00 3F 84 40 03 41 84 42 84 3C 32 B5 FE 18 3D 04 29 FE 0B 3C 14 00 AF FE 18 42 04 29 FE 0B 3C 14 00 AF FE 00 00 00 00 FE 04 12 9F 04 00 00 3F 03 40 84 41 84 42 84 3C 32 B5 12 9E 04 00 00 3F 84 40 84 41 03 42 84 3C 32 B5 12 9D 04 00 00 3F 84 40 84 41 84 42 03 3C 32 B5 12 6A 04 00 00 3F 84 40 03 41 84 42 84 3C 32 B5 FE ...
2011 12 16.56756 07 37 38.320 +32 52 12.85 22.0G 523742 F51 C~2kQo 2012 10 18.62701 07 43 16.714 +32 22 10.82 21.8G 523742 F51 C~2kQo 2012 10 31.52924 07 43 13.979 +32 24 40.32 22.2G 523742 F51 C~2kQo 2012 12 07.60393 07 41 48.830 +32 33 23.53 21.9G 523742 F51 C~2kQo 2012 12 22.54229 07 40 48.841 +32 36 47.08 21.2G 523742 F51 C~2kQo 2012 12 22.55633 07 40 48.810 +32 36 47.35 21.4G 523742 F51 C~2kQo 2012 12 22.57037 07 40 48.772 +32 36 47.36 21.2G 523742 F51 C~2kQo 2013 01 01.52079 07 40 03.973 +32 38 46.74 22.3G 523742 F51 C~2kQo 2013 12 06.50788 07 45 30.072 +32 15 48.50 21.9w 523742 F51 C~1vXk 2013 12 06.52013 07 45 30.039 +32 15 48.67 22.1w 523742 F51 C~1vXk 2013 12 06.53240 07 45 29.988 +32 15 48.84 22.1w 523742 F51 C~1vXk 2013 12 06.54462 07 45 29.942 +32 15 48.59 22.1w 523742 F51 C~1vXk 2014 01 04.42891 07 43 29.623 +32 22 08.26 22.0w 523742 F51 C~1vXk 2014 01 04.44206 07 43 29.556 +32 22 08.54 22.4w 523742 F51 C~1vXk 2014 01 04.45520 07 43 29.497 +32 22 08.53 22.1w 523742 F51 C~1vXk 2014 ...
001 003 004 005 006 007 008 009 011 011a 011b 011c 011d 011e 011f 011g 011h 011i 013 013a 013b 013c 013d 013e 013f 013g 013h 013i 014 014a 014b 014c 014d 014e 014f 014g 014h 014i 015 015a 015b 015c 015d 015e 015f 015g 015h 015i 016 016.general 016a 016a.general 016b 016b.general 016c 016c.general 016d 016d.general 016e 016e.general 016f 016f.general 016g 016g.general 016h 016h.general 016i 016i.general 017 017.general 017a 017a.general 017b 017b.general 017c 017c.general 017d 017d.general 017e 017e.general 017f 017f.general 017g 017g.general 017h 017h.general 017i 017i.general 019 019a 019b 019c 019d 019e 019f 019g 019h 019i 021 021a 021b 021c 021d 021e 021f 021g 021h 021i 022 022a 022b 022c 022d 022e 022f 022g 022h 022i 023 023a 023b 023c 023d 023e 023f 023g 023h 023i 025 025a 025b 025c 025d 025e 025f 025g 025h 025i 026 026a 026b 026c 026d 026e 026f 026g 026h 026i 027 027a 027b 027c 027d 027e 027f 027g 027h 027i 028 028.general 028a 028a.general 028b 028b.general 028c 028c.general 028d ...
There were no significant over-all effects of Category (F(1, 31) = 0.941, p = 0.340), Format (F(1, 31) = 0.0289, p = 0.595), nor any interaction between Category × Format (F(1, 31)=1.350, p = 0.254). Performance was equivalent Fulvestrant cell line at all ages; there was no main effect of Age: F(2, 31) = 2.2, p = 0.13, no interaction of Age × Category (F(2, 31) = 0.436, p = 0.650), Age × Format (F(2, 31) = 0.021, p = 0.811), nor a 3-way Age × Category × Format interaction (F(2, 31) = 0.510,. p = 0.606). Response times did not depend on Category (F(1, 31) = 0.011, p = 0.916), Presentation mode (F(1, 31) = 0.286, p = 0.596) or an interaction between these factors (F(1, 31) = 0.037, p = 0.849). Response times decreased with age (F(2, 31) = 17.63, p , 0.001; see Fig. 1C) but this decrease was not modulated by Category or Format (Category × Age (F(2, 31) = 0.262, p = 0.771); Format × Age (F(2, 31) = 0.780, p = 0.467); Category × Format × Age (F(2, 31) = 0.355, p = 0.704). Hence, any ...
2010 08 31.51282 23 26 26.019 -06 49 59.59 21.8G 14OR394 F51 C~2rYA 2010 09 07.45983 23 25 51.138 -06 53 09.72 22.1G 14OR394 F51 C~2rYA 2010 09 15.45103 23 25 10.372 -06 56 47.04 22.5G 14OR394 F51 C~2rYA 2010 09 16.49121 23 25 05.051 -06 57 14.51 22.7w 14OR394 F51 C~1vXg 2010 09 16.50264 23 25 04.985 -06 57 14.88 22.5w 14OR394 F51 C~1vXg 2010 09 16.52568 23 25 04.880 -06 57 15.90 22.4w 14OR394 F51 C~1vXg 2011 08 21.56632 23 34 44.820 -05 24 07.25 23.4G 14OR394 F51 C~2rYA 2011 08 23.48780 23 34 36.117 -05 24 56.33 22.5G 14OR394 F51 C~2rYA 2011 08 27.54622 23 34 17.060 -05 26 42.60 22.7G 14OR394 F51 C~2rYA 2011 09 04.50500 23 33 38.119 -05 30 17.88 22.6G 14OR394 F51 C~2rYA 2011 09 04.51641 23 33 38.054 -05 30 18.28 21.9G 14OR394 F51 C~2rYA 2011 09 21.36514 23 32 12.151 -05 37 58.49 21.8G 14OR394 F51 C~2rYA 2011 09 21.37920 23 32 12.069 -05 37 59.00 21.9G 14OR394 F51 C~2rYA 2011 09 21.39324 23 32 11.986 -05 37 59.28 21.7G 14OR394 F51 C~2rYA 2012 10 06.35353 23 38 28.444 -04 21 51.73 23.5G 14OR394 ...
https://www.food.dtu.dk/nyheder/videoer?approved=%7B34F6C6B0-C639-4CDC-925D-53D41E21A680%7D&at=%7B559A7F23-40D3-470C-8825-436C20C291CF%7D.%7B3F2A7F37-83AF-4BD8-A085-0BC04DA3EA92%7D.%7B18E4440F-E64C-4CF1-BDD9-860D6747C02D%7D.%7B0DE95AE4-41AB-4D01-9EB0-67441B7C2450%7D.%7B11111111-1111-1111-1111-111111111111%7D.%7B6306F3DE-B7A3-4D31-BAE5-FB8B9DB8C6C7%7D&descending=True&fr=1&mr=10&qt=TaggedItemSearch&sorton=DisplayDate&td=26-01-2020 ...
通过二次成功的细胞融合,共获得三株分泌抗玉米素核苷(ZR)的单克隆抗体的稳定杂交瘤细胞系(F_2E_6、F_3G_6、F_1B_9),其中F_2E_6分泌的单抗属IgG_1,F_5G_6,F_1B_9,分泌的单抗均属IgM,以F_2E_6,F_3G_6单抗为基础的间接酶联免疫吸附试法(ELISA)对ZR的检测灵敏度为0.05 Pmol(~18Pg),线性检测区界为0.05-50 Pmol。反式玉米素(t-z),顺式玉米素(c-z),异戊烯基腺苷(IPA)、6-苄基腺嘌呤(6-BA)、激动素(KT)和腺苷与ZR的竟争反应曲线表明,除玉米素以外,其它几种细胞分裂素的交叉反应值都低于0.18%,因此,F_3G_6、F_2E_6单抗具高度的特异性,用ELISA测定F_2E_6单抗与玉米素核苷反应的亲合常数为2.36 ± 0.99 * ...
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is chosen to be small, typically 0.01, 0.05 or 0.10. The hypothesis associated with each case enumerated above is rejected if: $$ \begin{array}{cl} 1. & F \le \frac{1}{F_{\alpha/2, \, \nu_2, \, \nu_1}} \mbox{ or } F \ge F_{\alpha/2, \, \nu_1, \, \nu_2} \\ & \\ 2. & F \ge F_{\alpha, \, \nu_1, \, \nu_2} \\ & \\ 3. & F \le \frac{1}{F_{\alpha, \, \nu_2, \, \nu_1}} \end{array ...
Englisch-Deutschwörterbuch (Übersetzer): Von Benutzern erweiterbares Wörterbuch für die Englisch-Deutsch-Übersetzung. Weitere Wörterbücher für andere Sprachen ebenfalls verfügbar! Buchstabe F - Seite 255
Englisch-Deutschwörterbuch (Übersetzer): Von Benutzern erweiterbares Wörterbuch für die Englisch-Deutsch-Übersetzung. Weitere Wörterbücher für andere Sprachen ebenfalls verfügbar! Buchstabe F - Seite 378
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The exposure level selection for the 2-year study was based on the 13-week study, which showed that rats could tolerate diets containing up to 50,000 ppm. Groups of 60 male and 60 female F344/N rats were fed diets containing 2,000, 10,000, or 50,000 ppm turmeric oleoresin for 104 (males) or 103 (females) weeks, which were estimated to deliver average daily doses of 80, 460, or 2,000 mg/kg to males and 90, 440, or 2,400 mg/kg to females. Nine or 10 rats from each exposure group were evaluated after 15 months.. Survival, Mean Body Weights, Feed Consumption, and Clinical Findings Survival of exposed male and female rats was similar to that of the controls (male: O ppm, 18/50; 2,000 ppm, 17/50; 10,000 ppm, 15/50; 50,000 ppm, 17/50; female: 33/50, 27/50, 28/50, 34/50). The final mean body weights of all exposed male rats and female rats receiving 2,000 and 10,000 ppm were similar to those of the controls. The final mean body weights of male and female rats that received 50,000 ppm were slightly lower ...
TY - JOUR. T1 - Age-related changes in the rate of esterification of plasma cholesterol in Fischer-344 rats. AU - Carlile, Shirley I.. AU - Kudchodkar, B. J.. AU - Wang, C. S.. AU - Lacko, Andras G.. N1 - Funding Information: This work was supported by the National Institutes of Health (AG-03255, HL-27620). The Robert A. Welch Foundation (B-935) and the American Heart Association (82-1043). The authors thank Dr. W.J. McConathy for making the human plasma samples available and also thank Gayle White and Shirley Barnes for excellent secretarial assistance.. PY - 1986/1. Y1 - 1986/1. N2 - Plasma cholesterol and triglyceride levels and selected molecular species of plasma cholesteryl esters and triglycerides were determined in 6-, 12-, 15-, 18-, 21- and 24-month-old Fischer-344 rats. Lecithin:cholesterol acyltransferase (LCAT) activity was also determined using two independent methods utilizing endogenous and exogenous substrates. Plasma cholesterol levels increased up to 18 months of age and then ...
This study was designed to examine the effects of a high-fat refined-sugar (HFS) or a low-fat complex-carbohydrate (LFCC) diet on insulin-stimulated skeletal muscle glucose transport, plasma insulin, blood pressure, plasma triglycerides, plasma glycerol, body weight, and body fat in female Fischer rats. Insulin-stimulated glucose transport was significantly reduced in the HFS group at 2 wk, 2 mo, and 2 yr, whereas serum insulin was significantly elevated at all time points. Blood pressure was not significantly elevated in the HFS group until 12 mo, and all HFS animals were hypertensive by 18 mo. Glycerol, triglycerides, and abdominal fat cell size were not significantly different at 2 wk but were significantly elevated in the HFS rats at 2 and 6 mo. Body weight was similar in both groups until 20 wk on the diet, when the HFS rats started to gain more weight. These results demonstrate that insulin resistance and hyperinsulinemia occur before the other manifestations of the metabolic syndrome and ...
The present study tested whether aging alters endotoxin-induced myocardial dysfunction in a sublethal model of endotoxemia in rats. The main findings were the following: 12 hours after LPS injection (0.5 mg/kg), a marked reduction in myocardial contractility was observed in the isolated perfused senescent heart; in contrast with septic cardiac dysfunction in young rats, myofilament Ca2+ sensitivity of left ventricular skinned fibers was not reduced in senescent rats; and NO production, oxidative stress, and antioxidant enzymes activities were not different between young adult and senescent LPS groups. Thus, despite similar alterations in potential mediators, cellular mechanisms responsible for this contractile dysfunction are different between young adult and senescent rats. More specifically, myofilament Ca2+ responsiveness remains unaltered in the senescent heart. This may have clinical implications for management of elderly septic patients.. Nonlethal models of endotoxemia have allowed ...
8-Hydroxydeoxyguanosine (8-OHdG) is a major oxidative DNA adduct playing roles in senescence, carcinogenesis and various disease processes. High-performance liquid chromatography with an electrochemical detection (HPLC-ECD) method has been widely used to assess organ levels of 8-OHdG, and a recently introduced immunohistochemical approach has made it possible to clarify intra-organ localization. In the present study, these methods were employed to reveal age-dependent changes in nuclear 8-OHdG within various tissues of male Fischer 344 rats between 18 fetal days and 104 weeks of age. 8-OHdG was detected in the nuclei of cerebellar small granule and small cortical cells, cerebral nerve cells, and choroid plexus epithelia of the brain and ependymal cells of the spinal cord; parenchymal cells in the anterior lobe of the pituitary and adrenal glands (mainly cortex); bronchial epithelium of the lung; intra-hepatic bile duct, pancreatic duct, glandular gastric and intestinal epithelial cells; renal tubular
Cyclohexanone oxime (CHOX), an intermediate used in the synthesis of Polycaprolactam/Nylon, was found to be rapidly absorbed and cleared from the body within 24 hours after a single oral administration of 1, 10 and 30 mg/kg of [14C]-CHOX to the adult male Fischer rats. The majority of the CHOX derived radioactivity (65-90% of the dose) was excreted in the urine. Elimination in the feces accounted for 5-10% of the dose and very low levels of radioactivity (2-3%) were retained in the tissues 24 hours after exposure. After iv administration of 1 mg/kg of [14C]-CHOX, the oxime was rapidly cleared from plasma with half-lives of 1.6 (alpha phase) and 18.2 min (beta phase). However, when CHOX was applied dermally (30 mg/kg), only about 4-5% of the dose was recovered in urine, feces and the tissues. The majority of the dose volatilized from the skin surface. However, the absorbed oxime was readily distributed and excreted, and its metabolic fate was no different than observed after oral administrations. ...
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To investigate the contributions of humoral and hemodynamic factors to cardiac adaptations associated with chronic exercise, female Fischer 344 rats were subjected to chronic swimming, infrarenal cardiac transplantation, or both. Swimming resulted in hypertrophy (11-12%) of the in situ hearts in both the unoperated and operated animals compared with the matched sedentary controls. The cardiac isograft exhibited atrophy (32-35%), which was not attenuated by swimming. The cardiac isograft was also associated with a decrease in the percent of V1 myosin isoenzyme, which was attenuated by swimming (45 +/- 5% versus 66 +/- 6%). Swimming also increased the percent of this isomyosin in the in situ hearts of operated rats. These data suggest that hemodynamic load and/or neural innervation are necessary for hypertrophy associated with chronic conditioning by swimming, whereas myosin isoenzyme control is significantly mediated by humoral factors. ...
In the last years several researches have shown the extent to which physical activity has been efficient in the treatment and prevention of disease. In the present work we studied biochemical and nutritional parameters that give us a general vision of the benefits of exercise for health. Forty five female Fisher rats were distributed into four groups which were subjected to swimming training in different volumes (30, 60, 120 and 240 minutes) as well as a sedentary group; all animals were fed a commercial ration and received food and water ad libitum. The results showed an increase in food intake, fecal volume and in heart weight as well as a decrease in body weight and in the weight of the finger long extensor and gastrocnemius muscles in the 240 group. In relation to glucose, hemoglobin and albumin an increase was observed in the groups that trained for longer periods (120 and 240 minutes). As for lipid profile, total cholesterol was diminished in the animals that swam 30 minutes. When hepatic ...
The intermediate conductance calcium activated potassium channel (KCa3.1) has a prominent role in numerous physiological functions, and has recently emerged as the main therapeutic target for many disorders and diseases ranging from lymphoma to Alzheimers disease. Much is known about the physiology and pharmacology of this channel, but how the numbers of the channel are regulated at the cell surface remains elusive today. Previous studies aimed to unravel the degradation pathway of KCa3.1 are predominantly based on non-polarised models, as KCa3.1 is widely expressed in polarised epithelial tissues, it is likely that the degradation pathway can present different patterns. In this study, I investigated the key molecular components that regulate the degradation of KCa3.1 using polarised epithelium generated by Fisher rat thyroid (FRT) cells stably expressing KCa3.1. Using immunoblot and Ussing chamber techniques, I demonstrated that KCa3.1 is degraded via an ubiquitin dependent pathway. Inhibition ...
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Fischer’s early life was riddled with success. He began playing competitively at age 8 and was the youngest player in history to win the United States Junior Championship, a feat he managed at age 13. Fischer took the first of his eight United States Open Championship wins at age 14. He broke another ‘youngest ever’ record when he became an international grand master at age 15.. Fischer continued his erratic career as a chess super-star, having his most famous match in 1972 against Boris Spassky. The American-Russian match was seen as a foreshadowing of the end of the Cold War as Fischer finished the tournament 12.5 points to Spassky’s 8.5 points over 21 matches. In addition to Fischer’s well-known reputation for gracelessness, rudeness, and unusual demands concerning playing conditions, he is remembered as the American that took down Russia in an allegorical struggle against our greatest nemesis of the day.. Deus Ex Machina blogs at Breakable News. ...
Eosinophils surrounded by red blood cells (stock image). Credit: © Kateryna_Kon / stock.adobe.com Frailty and immune decline are two main features of old age.
Male B6D2F1 (C57BL/6 × DBA/2F1) mice and female Fisher-344 rats were obtained from Harlan Sprague Dawley, Inc. (Indianapolis, IN; virus-free colony 202) at 28 days of age and housed in polycarbonate cages (5/cage). The animals were kept in a room lighted 12 h each day and maintained at 22 ± 0.5°C. Teklad (4%) diet (Harlan Teklad, Madison, WI) and tap water were provided ad libitum. Celecoxib (SC-635) was provided by Monsanto/Searle (St. Louis, MO).. In the mouse study, celecoxib was administered at 200, 500, and 1250 mg/kg of diet when the animals were 49 days of age and was continued throughout the study. At 56 days of age, carcinogen-treated mice received the first of 12 weekly intragastric doses of OH-BBN (TCI America, Portland, OR). Each 7.5-mg dose was dissolved in 0.1 ml ethanol:water (20:80). The mice were weighed weekly and checked daily. Some animals were lost during the first two weeks of the study due to gavage errors. These mice were excluded from the final analysis. After the ...
Data Neuralgia; input Treatment $ Sex $ Age Duration Pain $ @@; datalines; P F 68 1 No B M 74 16 No P F 67 30 No P M 66 26 Yes B F 67 28 No B F 77 16 No A F 71 12 No B F 72 50 No B F 76 9 Yes A M 71 17 Yes A F 63 27 No A F 69 18 Yes B F 66 12 No A M 62 42 No P F 64 1 Yes A F 64 17 No P M 74 4 No A F 72 25 No P M 70 1 Yes B M 66 19 No B M 59 29 No A F 64 30 No A M 70 28 No A M 69 1 No B F 78 1 No P M 83 1 Yes B F 69 42 No B M 75 30 Yes P M 77 29 Yes P F 79 20 Yes A M 70 12 No A F 69 12 No B F 65 14 No B M 70 1 No B M 67 23 No A M 76 25 Yes P M 78 12 Yes B M 77 1 Yes B F 69 24 No P M 66 4 Yes P F 65 29 No P M 60 26 Yes A M 78 15 Yes B M 75 21 Yes A F 67 11 No P F 72 27 No P F 70 13 Yes A M 75 6 Yes B F 65 7 No P F 68 27 Yes P M 68 11 Yes P M 67 17 Yes B M 70 22 No A M 65 15 No P F 67 1 Yes A M 67 10 No P F 72 11 Yes A F 74 1 No B M 80 21 Yes A F 69 3 No ...
We investigated the Pawn Sacrifice movie vs. the true story behind the Bobby Fischer vs. Boris Spassky chess match. Meet the real Bobby Fischer.
Zwander H., E. Fischer Wellenborn, H. Koll (2004): Der Pollenflug in Kärnten im Jahr 2003. - Carinthia II, 194./114.: 209-216, Klagenfurt. Zwander H., E. Fischer Wellenborn, H. Koll (2005): Der Pollenflug in Kärnten im Jahr 2004. - Carinthia II, 195./115.: 203-214, Klargenfurt. Zwander H., E. Fischer Wellenborn, H. Koll (2006): Der Pollenflug in Kärnten im Jahr 2005. - Carinthia II, 196./116.: 159-170, Klagenfurt. Zwander H., E. Fischer Wellenborn, H. Koll (2007): Der Pollenflug in Kärnten im Jahr 2006. - Carinthia II, 197./117.: 29-40, Klagenfurt. Zwander H., E. Fischer Wellenborn, H. Koll (2008): Der Pollenflug in Kärnten im Jahr 2007. - Carinthia II, 198./118.: 211-221, Klagenfurt. Zwander H. und Koll Herta (2009): Der Pollenflug im Jahr 2008. - Carinthia II, 199./119.: 169-182, Klagenfurt. Zwander H. und Koll Herta (2010): Der Pollenflug im Jahr 2009. - Carinthia II, 200./120.: 57-68, Klagenfurt. Zwander H., H. Koll und J. Horn (2011): Der Pollenflug im Jahr 2010. Mit einem Beitrag zur ...
Zwander H., E. Fischer Wellenborn, H. Koll (2004): Der Pollenflug in Kärnten im Jahr 2003. - Carinthia II, 194./114.: 209-216, Klagenfurt. Zwander H., E. Fischer Wellenborn, H. Koll (2005): Der Pollenflug in Kärnten im Jahr 2004. - Carinthia II, 195./115.: 203-214, Klargenfurt. Zwander H., E. Fischer Wellenborn, H. Koll (2006): Der Pollenflug in Kärnten im Jahr 2005. - Carinthia II, 196./116.: 159-170, Klagenfurt. Zwander H., E. Fischer Wellenborn, H. Koll (2007): Der Pollenflug in Kärnten im Jahr 2006. - Carinthia II, 197./117.: 29-40, Klagenfurt. Zwander H., E. Fischer Wellenborn, H. Koll (2008): Der Pollenflug in Kärnten im Jahr 2007. - Carinthia II, 198./118.: 211-221, Klagenfurt. Zwander H. und Koll Herta (2009): Der Pollenflug im Jahr 2008. - Carinthia II, 199./119.: 169-182, Klagenfurt. Zwander H. und Koll Herta (2010): Der Pollenflug im Jahr 2009. - Carinthia II, 200./120.: 57-68, Klagenfurt. Zwander H., H. Koll und J. Horn (2011): Der Pollenflug im Jahr 2010. Mit einem Beitrag zur ...
0000: 44 20 32 30 31 32 2d 31 32 2d 31 37 54 31 37 3a D 2012-12-17T17: 0010: 35 36 3a 32 30 2e 32 31 35 0a 4c 20 63 6f 6d 70 56:20.215.L comp 0020: 69 6c 6c 69 6e 67 4f 6e 57 69 6e 64 6f 77 73 0a illingOnWindows. 0030: 50 20 63 31 62 31 62 61 30 31 62 36 37 63 39 35 P c1b1ba01b67c95 0040: 39 38 63 35 32 36 64 62 31 35 38 64 33 36 61 66 98c526db158d36af 0050: 62 33 61 34 37 35 36 34 32 31 0a 55 20 61 6e 6f b3a4756421.U ano 0060: 6e 79 6d 6f 75 73 0a 57 20 36 39 35 32 0a 3c 68 nymous.W 6952.,h 0070: 33 3e 43 6f 6d 70 69 6c 69 6e 67 20 75 6e 64 65 3,Compiling unde 0080: 72 20 77 69 6e 64 6f 77 73 20 3c 62 69 67 3e 58 r windows ,big,X 0090: 50 3c 2f 62 69 67 3e 20 77 69 74 68 20 73 64 6b P,/big, with sdk 00a0: 20 63 6f 6d 70 69 6c 65 72 2e 3c 2f 68 33 3e 0d compiler.,/h3,. 00b0: 0a 20 20 2a 20 20 64 6f 77 6e 6c 6f 61 64 20 5b . * download [ 00c0: 68 74 74 70 3a 2f 2f 77 77 77 2e 6d 69 63 72 6f http://www.micro 00d0: 73 6f 66 74 2e 63 6f 6d 2f 64 6f 77 6e 6c 6f 61 soft.com/downloa 00e0: 64 73 2f 64 ...
Results for 2017 Brazos River Sharkfest Swim F4549 2K Female in Waco, TX United States. Times for Manual wave start Swimming - open water race.
Novus Scientific (www.novusscientific.com) är en innovatör inom forskning och kommersialisering av resorberbara implantat som hjälper kroppens egen läkning. Huvudkontor, utveckling och produktion ligger i Uppsala och försäljning sker via distributörer i ett växande antal länder, för närvarande ett tjugotal.Företagets ägare och företagsledning kommer från Uppsalabaserade Radi Medical Systems AB, köpt av St Jude Medical Inc 2008. Det först utvecklade och saluförda implantatet är TIGR® Matrix (www.TIGRmatrix.com) som är ett kirurgiska nät, som bidrar med mekanisk hållfasthet tills kroppen själv återskapat vävnadens styrka för att sedan utsöndras via naturliga vägar. Främsta användningsområden är: · Att stabilisera vävnaden runt implantat i samband med bröstrekonstruktion efter cancer. · Att återställa bukväggens funktion efter komplexa ärrbråck. · Att förstärka bukförslutningen efter öppenbukskirurgi för att minska risken för sårruptur och
RFC 7518 JSON Web Algorithms (JWA) May 2015 B.3. Test Cases for AES_256_CBC_HMAC_SHA_512 K = 00 01 02 03 04 05 06 07 08 09 0a 0b 0c 0d 0e 0f 10 11 12 13 14 15 16 17 18 19 1a 1b 1c 1d 1e 1f 20 21 22 23 24 25 26 27 28 29 2a 2b 2c 2d 2e 2f 30 31 32 33 34 35 36 37 38 39 3a 3b 3c 3d 3e 3f MAC_KEY = 00 01 02 03 04 05 06 07 08 09 0a 0b 0c 0d 0e 0f 10 11 12 13 14 15 16 17 18 19 1a 1b 1c 1d 1e 1f ENC_KEY = 20 21 22 23 24 25 26 27 28 29 2a 2b 2c 2d 2e 2f 30 31 32 33 34 35 36 37 38 39 3a 3b 3c 3d 3e 3f P = 41 20 63 69 70 68 65 72 20 73 79 73 74 65 6d 20 6d 75 73 74 20 6e 6f 74 20 62 65 20 72 65 71 75 69 72 65 64 20 74 6f 20 62 65 20 73 65 63 72 65 74 2c 20 61 6e 64 20 69 74 20 6d 75 73 74 20 62 65 20 61 62 6c 65 20 74 6f 20 66 61 6c 6c 20 69 6e 74 6f 20 74 68 65 20 68 61 6e 64 73 20 6f 66 20 74 68 65 20 65 6e 65 6d 79 20 77 69 74 68 6f 75 74 20 69 6e 63 6f 6e 76 65 6e 69 65 6e 63 65 IV = 1a f3 8c 2d c2 b9 6f fd d8 66 94 09 23 41 bc 04 A = 54 68 65 20 73 65 63 6f 6e 64 20 70 72 69 6e 63 69 70 6c 65 20 6f 66 ...
Projektledningsmodellen PROPS är framtagen utav Ericsson under 1980-talet. Den gerriktlinjer för hur olika projektarbeten ska fungera och är i den meningen också väldigtgenerell. I dagsläget finns det ingen specifik metod som kompletterar den vidimplementering av standardsystem. Standardsystem är en form av IT-lösning,programvara, som direkt kan tas i bruk. Normalt krävs dock vissa anpassningar såväl isjälva systemet som i företagets verksamhet för att få en fungerande lösning.Studien har i syfte att ta reda på om Välja och Förvalta Standardsystem-metoden (VFS)skulle kunna vara ett komplement till PROPS. Vilket kräver mer ingående kunskap omde två olika modellerna. En litteraturstudie gjordes för att få en större teoretisk grund iämnet. Jämförelsen av modellerna gjordes utifrån vanligt förekommande kriterier inomprojektledning. Behandlade kriterier är: planering, strategi, mål, budget, risker ochrapportering.Avgränsningar har gjorts såtillvida att studien ej ...
Note: You are currently viewing documentation for Moodle 2.5. Up-to-date documentation for the latest stable version of Moodle may be available here: Fischer projections question type.. ...
Georg Fischer với hơn 60.000 sản phẩm cho hơn 200 năm nghiên cứu, phát triển bởi một đội ngũ chuyên dụng, đa dạng về sản phẩm và chuyên môn bao gồm các đường ống, phụ kiện, van và công nghệ tự động hóa ...
IRMNG (2021). Bulinidae P. Fischer & Crosse, 1880. Accessed at: https://www.irmng.org/aphia.php?p=taxdetails&id=103034 on 2021-09-24 ...
ATOM 89 CA CYS A 12 29.215 -1.013 17.747 1.00 23.10 C ATOM 92 CB CYS A 12 30.264 -1.172 18.849 1.00 23.68 C ATOM 93 SG CYS A 12 29.632 -1.020 20.503 1.00 25.01 S ATOM 1385 C31 94F A 203 16.511 -4.125 24.817 1.00 32.17 C ATOM 1386 C30 94F A 203 15.606 -4.260 23.787 1.00 32.36 C ATOM 1387 C32 94F A 203 17.840 -3.910 24.531 1.00 31.54 C ATOM 1388 C29 94F A 203 16.037 -4.183 22.484 1.00 32.47 C ATOM 1389 C19 94F A 203 21.614 -2.199 22.881 1.00 29.12 C ATOM 1390 C5 94F A 203 23.964 -5.464 22.540 1.00 29.57 C ATOM 1391 C18 94F A 203 22.453 -3.293 22.771 1.00 29.13 C ATOM 1392 C23 94F A 203 18.284 -3.829 23.223 1.00 31.43 C ATOM 1393 C22 94F A 203 19.692 -3.612 23.019 1.00 29.79 C ATOM 1394 C24 94F A 203 17.372 -3.972 22.203 1.00 32.05 C ATOM 1395 C3 94F A 203 21.900 -4.565 22.770 1.00 29.39 C ATOM 1396 C2 94F A 203 20.533 -4.693 22.895 1.00 29.45 C ATOM 1397 C20 94F A 203 20.247 -2.347 23.012 1.00 29.51 C ATOM 1398 C7 94F A 203 23.836 -3.189 22.644 1.00 28.94 C ATOM 1399 C14 94F A 203 29.536 0.583 ...
Let A, $X_1$ and $X_2$ be topological spaces and let $i_1 : A → X_1$, $i_2: A → X_2$ be continuous maps. For all self-maps $f_A: A → A$, $f_1: X_1 → X_1$ and $f_2: X_2 → X_2$ such that $f_1i_1 = i_1f_A$ and $f_2i_2=i_2f_A$ there exists a pushout map f defined on the pushout space $X_1 ⊔_A X_2$. In [F] we proved a formula relating the generalized Lefschetz numbers of f, $f_A$, $f_1$ and $f_2$. We had to assume all the spaces involved were connected because in the original definition of the generalized Lefschetz number given by Husseini in [H] the space was assumed to be connected. So, to extend the result of [F] to the not necessarily connected case, a definition of generalized Lefschetz number for a map defined on a not necessarily connected space is given; it reduces to the original one when the space is connected and it is still a trace-like quantity. It allows us to prove the pushout formula in this more general case and therefore to get a tool for computing Nielsen and ...
Barn med funktionsnedsättning kan sägas leva i ett kraftfält mellan föräldrarna och de professionella. Föräldrarna kan slitas mellan expertisens kunskaper - och egna tankar om vad som är bäst för barnet. Det är därför viktigt att de professionella även har fokus på föräldrarnas situation och välbefinnande - vilket i sin tur påverkar barnets psykiska välmåga. Barnet och föräldrarna måste också få möjlighet att utveckla sitt samspel genom att bara Vara.. ...
a er f lk sem arf a taka st rri kvar anir en g er f r um a gera og g get ekki st rt v . Eina sem g get gert er a reyna a f ra f laginu vir ingu og eitthva til a vera stolft af en a er lj st a a hefur horfi s ustu r og a er mitt verk a n v til baka. Til ess a a s h gt arf hins vegar anna f lk a sinna starfi s nu, sag i Rooney ...
Tamron SP 35mm F1.4 USD (F045) Review | Photographer Dustin Abbott shares a real-world review of one of Tamrons best-ever lenses - the SP 35mm F1.4 (F045)
B+W närbildslinser är högkvalitativt förstoringslins som förbättrar närgränsen för kameraobjektiv. Det gör det möjligt att gå närmare motivet för att få en större bildskala.
Nov 14 11:24 356511 km ++ F- 2h 2016 Mar 8 8:36 356529 km ++ F- 1h 1993 Jan 19 22:13 356548 km ++ F+ 0h 1992 Dec 12 21:38 356567 km ++ F+ 4h 2008 Mar 19 19:10 356577 km ++ F+ 0h 2011 Jan 30 9:04 356592 km ++ F+ 2h 2010 Nov 4 0:42 356614 km ++ F- 4h 1998 Dec 22 11:01 356654 km ++ F- 6h 2001 Dec 22 11:01 356654 km ++ F- 6h 1999 Oct 26 11:52 356754 km ++ F+ 6h 2007 Feb 7 22:20 356852 km ++ F- 8h 2002 Sep 28 1:47 356876 km ++ F- 1h 2015 Aug 10 17:44 356896 km ++ F- 0h 2014 Apr 25 17:18 356925 km ++ F- 2h 1994 Jul 30 7:37 356948 km ++ F- 2h 1996 May 6 3:34 356953 km ++ F- 0h 2012 Sep 16 15:25 356965 km + F- 3h 1997 Jun 23 11:11 356989 km ++ F- 0h 2013 Jun 13 1:06 357006 km + F- 2h 1995 Apr 17 4:59 357157 km + F+ 9h 2003 Jul 21 19:46 357159 km F+ 8h 2005 Sep 8 3:08 357174 km + F+ 8h 2006 Jun 3 13:11 357248 km ++ F+ 8h 2004 Jan 10 10:53 357500 km + F- 16h 2009 Dec 22 9:29 358353 km F+ 23h 1991 Nov 14 22:59 366050 km F+3d 1h 2000 ...
Signed-off-by: Józef Kucia ,jkucia at codeweavers.com, --- dlls/d3d11/tests/d3d11.c , 37 ++++++++++++++++++++++++++++++++++++- 1 file changed, 36 insertions(+), 1 deletion(-) diff --git a/dlls/d3d11/tests/d3d11.c b/dlls/d3d11/tests/d3d11.c index 2c31490..94fd367 100644 --- a/dlls/d3d11/tests/d3d11.c +++ b/dlls/d3d11/tests/d3d11.c @@ -15967,6 +15967,38 @@ void main(point struct gs_data vin[1], inout TriangleStream,gs_data, vout) 0x00000000, 0x00004001, 0x3f800000, 0x06000036, 0x001020f2, 0x00000001, 0x00201e46, 0x00000000, 0x00000001, 0x01000013, 0x0100003e, }; + static const DWORD gs_5_0_code[] = + { + 0x43425844, 0x57251c23, 0x4971d115, 0x8fee0b13, 0xba149ea1, 0x00000001, 0x00000384, 0x00000003, + 0x0000002c, 0x00000080, 0x000000dc, 0x4e475349, 0x0000004c, 0x00000002, 0x00000008, 0x00000038, + 0x00000000, 0x00000001, 0x00000003, 0x00000000, 0x00000f0f, 0x00000044, 0x00000000, 0x00000000, + 0x00000003, 0x00000001, 0x00000f0f, 0x505f5653, 0x5449534f, 0x004e4f49, 0x4f4c4f43, 0xabab0052, + ...
Chari, A.; Haselbach, D.; Kirves, J. M.; Ohmer, J.; Paknia, E.; Fischer, N.; Ganichkin, O.; Moller, V.; Frye, J. J.; Petzold, G. et al.; Jarvis, M.; Tietzel, M.; Grimm, C.; Peters, J. M.; Schulman, B. A.; Tittmann, K.; Markl, J.; Fischer, U.; Stark, H.: ProteoPlex: Stability optimization of macromolecular complexes by sparse-matrix screening of chemical space. Nature Methods 12 (9), S. 859 - 865 (2015 ...
Publikations-Datenbank der Fraunhofer Wissenschaftler und Institute: Aufsätze, Studien, Forschungsberichte, Konferenzbeiträge, Tagungsbände, Patente und Gebrauchsmuster
This is a list of crashes just since this month started. Many within the last 15 minutes. e634bc91-6ece-460f-b541-d4414c3924a7 10/4/2015 5:55 PM e83396ef-b8f3-4772-8668-6576c1e343bd 10/4/2015 5:55 PM 8a982ad3-6f95-4f96-b791-e11e3ed71ec4 10/4/2015 5:55 PM c97b4ae4-2112-491a-a139-e9705f5ad3ae 10/4/2015 5:54 PM 1495fecb-1a5c-4006-9151-d87eec8570c4 10/4/2015 5:49 PM 96950c62-eac7-419f-8c1e-3118e83715aa 10/4/2015 5:49 PM 208b8de3-ed66-4c4f-8b3f-70131a2b3958 10/4/2015 5:48 PM f4529ef8-03df-4e91-9e73-1d941faf87ee 10/4/2015 5:48 PM 54d67e13-94fb-4850-a187-1b5c079bee8c 10/4/2015 5:47 PM e713f7e3-2b49-4f70-be2c-be193079a3e9 10/4/2015 5:42 PM 1e5c4e24-b331-4184-b269-2f4614255a45 10/4/2015 5:40 PM e3257b7e-d43a-4298-99b6-d9b1673879c2 10/4/2015 5:40 PM 4608a461-a4a3-4d03-bdc8-12ea5bc170b8 10/4/2015 5:40 PM 780e50bf-4fac-4fa3-b384-26951454e666 10/4/2015 5:40 PM 54f334c3-c72e-4dee-834a-09fd451222c3 10/4/2015 5:40 PM ea8c292a-4741-47dd-a2cd-3e5e486f0a77 10/4/2015 5:40 PM 311fb571-478c-4bb0-8ee9-70de5ae2cbfa ...
Haricots, jaunes (f ve) - Tout ce que vous devez savoir propos de laliment Haricots, jaunes (f ve) : Toutes les informations nutritionnelles de Haricots, jaunes (f ve)
F10-18g found in: F10-18G(X), F10-18GC(X), F10-18GC, 3 Piece Thrust, Grooved Races TB (10X18X5.5) MM, 3 Piece Thrust, Ceramic Hybrid, Grooved Races TB..
BAMSE FÖR DE YNGSTA - TIDNINGSPRENUMERATION i Tidningsarkivet. Ett digitalt arkiv för svenska tidningar och tidskrifter. Här finns bland annat omslag och innehållstexter för BAMSE FÖR DE YNGSTA - TIDNINGSPRENUMERATION.
F1 RACING i Tidningsarkivet. Ett digitalt arkiv för svenska tidningar och tidskrifter. Här finns bland annat omslag och innehållstexter för F1 RACING.
0000: 54 68 69 73 20 77 69 6c 6c 20 62 75 69 6c 64 20 This will build 0010: 61 20 54 63 6c 6b 69 74 20 6e 61 6d 65 64 20 22 a Tclkit named 0020: 74 63 6c 6b 69 74 2d 3c 76 65 72 73 69 6f 6e 3e tclkit-,version, 0030: 22 20 6f 72 20 61 20 4b 69 74 44 4c 4c 20 6e 61 or a KitDLL na 0040: 6d 65 64 0a 22 6c 69 62 74 63 6c 6b 69 74 3c 76 med.libtclkit,v 0050: 65 72 73 69 6f 6e 3e 2e 73 6f 22 2e 0a 0a 2d 2d ersion,.so...-- 0060: 2d 2d 2d 2d 2d 2d 2d 2d 2d 2d 2d 2d 2d 0a 55 73 -------------.Us 0070: 69 6e 67 20 54 68 69 73 20 54 6f 6f 6c 0a 2d 2d ing This Tool.-- 0080: 2d 2d 2d 2d 2d 2d 2d 2d 2d 2d 2d 2d 2d 0a 55 73 -------------.Us 0090: 61 67 65 3a 0a 09 6b 69 74 63 72 65 61 74 6f 72 age:..kitcreator 00a0: 20 5b 7b 62 75 69 6c 64 20 7c 20 72 65 74 72 79 [{build , retry 00b0: 20 7c 20 63 6c 65 61 6e 20 7c 20 64 69 73 74 63 , clean , distc 00c0: 6c 65 61 6e 7d 5d 0a 09 20 20 20 20 20 20 20 20 lean}].. 00d0: 20 20 20 5b 7b 3c 76 65 72 73 69 6f 6e 3e 20 7c [{,version, , 00e0: 20 63 76 73 5f 3c 74 61 ...
Question1: The manager of a small company is interested in increasing the French language literacy of his employees. Three different training programmes were investigated, and as a result of these investigations, the manager sent.
There is a table of values for the function f. They read: x=3, f(x)=4 x=4 f(x)=5 x=5 f(x)=6 x=6 f(x)=3 x=7 f(x)=5 x=8 f(x)=7 What is the value of 2f(5)-f(4)? I did this wrong obviously, but what I did was figure out the function of five from the table (4), and multiplied that ... ...
Easy Skin Care HF abil on jäätumine nahasuuskade ja tuurisuuskade nahkade jaoks minevik. Fluoritud vedel vaha vähendab naha jäätumist muutuvates ti...
... rats, inbred f344 MeSH B01.050.157.760.275 - rats, inbred lec MeSH B01.050.157.760.280 - rats, inbred lew MeSH B01.050.157.760. ... rats, inbred f344 MeSH B01.050.199.520.760.275 - rats, inbred lec MeSH B01.050.199.520.760.280 - rats, inbred lew MeSH B01.050. ... rats, inbred aci MeSH B01.050.157.760.090 - rats, inbred bb MeSH B01.050.157.760.110 - rats, inbred bn MeSH B01.050.157.760.130 ... rats, inbred shr MeSH B01.050.157.760.360 - rats, inbred wf MeSH B01.050.157.760.390 - rats, inbred wky MeSH B01.050.199.040 - ...
The Rat Genome Database [1] maintains the most current list of inbred rat lines and their characteristics. A genealogical chart ... Strains dating back to this time include F344, M520 and Z61 and later ACI, ACH, A7322 and COP. Tryon's classic work on ... and later to the common use of inbred rats by experimental psychologists." Wistar as a generic name for inbred strains such as ... Inbred strains (also called inbred lines, or rarely for animals linear animals) are individuals of a particular species which ...
There are SeV-resistant F344 rats and susceptible BN rats. In the host airways the virus titer reaches a peak after 5-6 days ... Inbred and outbred mouse and rat strains have very different susceptibility to Sendai virus infection. Visualization of SeV ... "Sendai Virus (SV)". Rat Guide. Kraft V, Meyer B (June 1986). "Diagnosis of murine infections in relation to test methods ... Two approaches have been used to overcome this problem and make Sendai virus non-pathogenic for mice and rats. One of these ...
Rats, Inbred Strains [B01.050.150.900.649.865.635.505.700.400]. *Rats, Inbred F344 [B01.050.150.900.649.865.635.505.700.400.200 ... Inbred F344" by people in Harvard Catalyst Profiles by year, and whether "Rats, Inbred F344" was a major or minor topic of ... "Rats, Inbred F344" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical Subject ... Rats, Inbred F344*Rats, Inbred F344. *F344 Rat, Inbred. *F344 Rats, Inbred ...
Rats, Inbred F344 * Recombinant Proteins / administration & dosage * Recombinant Proteins / pharmacology Substances * ... Methods: Leptin (1 mg/kg/d) or vehicle was administered systemically by miniosmotic pump in Fischer 344 rats either for 7 days ... Results: In systemic leptin-treated rats, plasma leptin levels were 4- to 5-fold increased (P , 0.008 to P , 0.001); labeling ... Leptin reduces the development of the initial precancerous lesions induced by azoxymethane in the rat colonic mucosa ...
... inhibits colon carcinogenesis in the post-initiation stage in male F344 rats treated with azoxymethane (AOM) without any overt ...
This study was designed to determine the possible mechanism by which orotic acid exerts its mitoinhibitory effect on rat ... Rats. Rats, Inbred F344. Ribonucleoside Diphosphate Reductase / antagonists & inhibitors. Transforming Growth Factor alpha / ... This study was designed to determine the possible mechanism by which orotic acid exerts its mitoinhibitory effect on rat ... or plasma from rats exposed to various liver cell-proliferative stimuli, such as two-thirds partial hepatectomy, lead nitrate, ...
As cultured rat preadipocytes became differentiated, FFA transfer into preadipocytes increased and was more rapid in single pe ... Rats. Rats, Inbred F344. Stem Cells / metabolism*. Substrate Specificity. Tumor Suppressor Proteins*. ... As cultured rat preadipocytes became differentiated, FFA transfer into preadipocytes increased and was more rapid in single ... 3507236 - The effect of storage on rat tissues and human plasma amino acid levels determined by h.... 6295766 - The acute ...
Rats, Inbred F344. 1. 2011. 930. 0.110. Why? Down-Regulation. 1. 2018. 3328. 0.110. Why? ...
Rats; Rats, Inbred F344 ... protoporphyrin and heme were compared in rat and chick embryo ... In rat cultures, zinc protoporphyrin was synthesized enzymatically by ferrochelatase, since N-methylmesoporphyrin, an inhibitor ... but decreased all three in rat hepatocytes, with the decrease in protoporphyrin being far greater than that of zinc ...
Inbred BALB C; Mice, Nude; Mutation; Rats; Rats, Inbred F344; Trachea/physiology*; Tracheal Neoplasms/genetics*; Tumor Cells, ... Abstract: The effect of an activated H-ras oncogene on the progression of neoplasia was studied in transformed rat tracheal ... Title: Role of H-ras in the malignant progression of rat tracheal epithelial cells. ... suggesting the importance of alternative pathways in malignant progression of rat tracheal epithelial cells. ...
... a new set of rat recombinant inbred strains between LE/Stm and F344Mamm. Genome8324327Google Scholar ... As potential standards, the F344 inbred strain and an outbred stock of Long Evans were tested with three other inbred strains. ... Behavioral phenotyping F344 LE rats standard strain THE TLE This is a preview of subscription content, log in to check access. ... The inclusion of a standard strain or stock in phenotyping protocols involving multiple inbred strains or lines of rats, mice ...
Rats. *Rats, Inbred F344. *Receptors, NK Cell Lectin-Like. *Recombinant Proteins/immunology ... Bottom Line: To define Ly-49D-ligand interactions, we transfected the mouse Ly-49D receptor into the rat NK line, RNK-16 (RNK. ... Bottom Line: To define Ly-49D-ligand interactions, we transfected the mouse Ly-49D receptor into the rat NK line, RNK-16 (RNK. ... To define Ly-49D-ligand interactions, we transfected the mouse Ly-49D receptor into the rat NK line, RNK-16 (RNK.mLy-49D). As ...
Mentions: Transplantation of GDAs into stab-wound lesions of the dorsal column white matter pathways of adult rat spinal cord ( ... Mentions: Transplantation of GDAs into stab-wound lesions of the dorsal column white matter pathways of adult rat spinal cord ( ... Grid-walk analysis of GDA-transplanted rats with rubrospinal tract injuries revealed significant improvements in locomotor ... Grid-walk analysis of GDA-transplanted rats with rubrospinal tract injuries revealed significant improvements in locomotor ...
Animals. Male F344 rats (85-110 g) were purchased from Harlan (Indianapolis, IN). ICR wild-type and Nrf2-disrupted mice were ... generated from inbred Nrf2-heterozygous mice ( 17). Animals were fed AIN-76A purified diet without ethoxyquin. All experiments ... Forty-eight hours after treatment with CDDO-Im, rats were gavaged with 25 μg/rat of AFB1 dissolved in DMSO. Rats were ... Protection against aflatoxin B1-induced hepatocarcinogenesis in F344 rats by 5-(2-pyrazinyl)-4-methyl-1,2-dithiole-3-thione ( ...
The DA rat strain was used to establish a lung exposure model. Five other inbred rat strains (PVG, PVG.1AV1, LEW, WF and F344) ... All rat strains displayed a biphasic pattern of leukocyte infiltration in the lungs, dominated by neutrophils 2 days after ... The number of macrophages was higher in the DA rat compared with the other strains. The infiltration of lymphocytes in the ... With a novel focus on the immune system this paper investigate whether late phase pulmonary effects developed in rats exposed ...
The parameters of the hearing function were not different in the young (3-month-old) male and female F344 rats; the gender ... The parameters of the hearing function were not different in the young (3-month-old) male and female F344 rats; the gender ... In this study, we systematically compare the hearing function during aging in male and female F344 rats, by recording auditory ... In this study, we systematically compare the hearing function during aging in male and female F344 rats, by recording auditory ...
4). Whereas the predicted Nat3 ORF from the BN rat strain has a guanine (G) at nucleotide 358, the inbred rat strains F344, WKY ... In addition, since the Brown Norway (BN) inbred rat strain is genetically closer to wild rats than it is to other inbred rat ... Cloning and Sequencing Rat Nat3. The Nat3 ORF in inbred strains F344, WKY, and SPRD were identical (Gen-Bank accession nos. ... Rat Nat3 nucleotide sequence is 75.7% identical to rat Nat1 and 78.0% identical to rat Nat2; rat Nat3 amino acid sequence is ...
Inbred DRH and F344 rats were purchased from SEAC Yoshitomi, Ltd. (Fukuoka, Japan) at 4 weeks of age and allowed to acclimatize ... F2 rats were generated by intercrossing male and female (F344 × DRH)F1 rats. Starting at 5 weeks of age, male F2 rats were fed ... De Miglio et al. (10) recently reported genetic resistance of BN rats to chemically induced HCC in (BN × F344) × F344 rats. The ... The inbred rat strain DRH was established from a closed colony of Donryu rats continuously fed 3′-Me-DAB and selected for ...
For example, the inbred rat strain LEW has been shown to self-administer stimulant drugs more readily than the F344 strain. ... The SC rats differed according to genotype, with SC LEW rats taking more amphetamine than SC F344 rats. An interaction of ... This study examined gene-by-environment interactions in susceptibility to drug use by raising LEW and F344 rats in varied ... The enriched rats of both strains showed less amphetamine self-administration, while the isolated rats of both strains were ...
Genes influencing spinal bone mineral density in inbred F344, LEW, COP, and DA rats. Alam I; Sun Q; Koller DL; Liu L; Liu Y; ... Quantitative trait locus for body weight identified on rat chromosome 4 in inbred alcohol-preferring and -nonpreferring rats: ... Sex-specific genetic loci for femoral neck bone mass and strength identified in inbred COP and DA rats. Alam I; Sun Q; Liu L; ... Genetic loci affecting bone structure and strength in inbred COP and DA rats. Sun Q; Alam I; Liu L; Koller DL; Carr LG; Econs ...
Genes influencing spinal bone mineral density in inbred F344, LEW, COP, and DA rats. Alam I; Sun Q; Koller DL; Liu L; Liu Y; ... Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. Rodd ... Gene expression in the hippocampus of inbred alcohol-preferring and -nonpreferring rats. Edenberg HJ; Strother WN; McClintick ... Functional gene expression differences between inbred alcohol-preferring and -non-preferring rats in five brain regions. Kimpel ...
Differences in the behavioral responses of Lewis and Fischer (F344) inbred rat strains to stress and psychoactive drugs have ... Together these findings suggest that the inbred, behaviorally divergent F344 and Lewis rats have selective differences in ... corticosterone levels on multiple dopamine neurochemical estimates were examined in inbred Fischer and Lewis inbred rat strains ... In unstressed control animals, the Lewis strain had lower DA concentrations in the dorsal striatum (ST; 80.3% of F344) and ...
Inbred F344 Rats All Science Journal Classification (ASJC) codes. *Molecular Biology. *Pulmonary and Respiratory Medicine ... Control rats showed only resident alveolar macrophages (AM) in the BALF with no apoptosis. At the peak of injury, 1 h and 4 h ... Control rats showed only resident alveolar macrophages (AM) in the BALF with no apoptosis. At the peak of injury, 1 h and 4 h ... Control rats showed only resident alveolar macrophages (AM) in the BALF with no apoptosis. At the peak of injury, 1 h and 4 h ...
β-Funaltrexamine (β-FNA) and the regulation of body and brain development in rats. Zagon, I. & McLaughlin, P., Jan 1 1986, In ... μ-opioid receptor trafficking on inhibitory synapses in the rat brainstem. Browning, K. N., Kalyuzhny, A. E. & Travagli, R. A. ... μ opioid receptor agonist DAMGO-induced suppression of saccharin intake in Lewis and Fischer rats. Liu, C. & Grigson-Kennedy, P ...
Rats, Inbred F344. MESH. Dewey Decimal Classification:. 500 Science , 570 Life sciences. 500 Science , 540 Chemistry & allied ... Kager, M., Spruss, T., Schneider, M. R. and Angerer, E. von (1992) Dunning R3327-G prostate carcinoma of the rat: an ... Models for testing new drugs for the treatment of hormone-dependent prostate cancer are restricted to a few in vivo rat tumour ... Models for testing new drugs for the treatment of hormone-dependent prostate cancer are restricted to a few in vivo rat tumour ...
Rats, Inbred F344. MESH. Receptors, Androgen/metabolism. MESH. Testosterone/antagonists & inhibitors. MESH. ... In rats bearing Dunning R3327-G prostate carcinomas casodex exerted a strong antitumour effect at the beginning of therapy. ... Analysis of endocrine effects in rats after 15 days of treatment revealed a strong reduction of the weights of prostates and ... Analysis of endocrine effects in rats after 15 days of treatment revealed a strong reduction of the weights of prostates and ...
Methods: Bacteria S. aureus (ATCC #49775) and F98 and 9L glioma cells were injected stereotactically in the brains of F344 rats ... Methods: Bacteria S. aureus (ATCC #49775) and F98 and 9L glioma cells were injected stereotactically in the brains of F344 rats ... Methods: Bacteria S. aureus (ATCC #49775) and F98 and 9L glioma cells were injected stereotactically in the brains of F344 rats ... Methods: Bacteria S. aureus (ATCC #49775) and F98 and 9L glioma cells were injected stereotactically in the brains of F344 rats ...
... rats were obtained from Japan SLC Inc (Hamamatsu, Japan). The inbred male LEW (RT1l) and F344 (RT1lvl) rats and Wistar rats ... Rat skin transplantation was performed using 5-week-old male rats according to Taylors procedure.8 The skin of LEW rat was ... LEW to F344) rat combination. Histopathological and immunohistochemical analysis at 100 days after mHC-disparate rat heart ... LEW-to-F344 carotid artery allografts: analysis of a rat model of posttransplant vascular injury involving cell-mediated and ...
86) assessed renal function in F344/DuCrlCrlj rats, a substrain of the inbred Fischer 344 strain lacking DPP-4 enzyme activity ... 92) assessed whether vildagliptin had a renoprotective activity in STZ-induced diabetic rats. Diabetic and nondiabetic rats ... Using the F344/DuCrlCrlj rat model, it was demonstrated that DPP-4 deficiency improves postischemic BM EPC mobilization and ... Beneficial effects of vildagliptin on retinal injury in obese type 2 diabetic rats. Ophthalmic Res 2013;50:221-226pmid:24081217 ...
Inbred strains of male F344 and WKAH rats were purchased from Charles River Japan (Atsugi, Kanagawa, Japan) and Japan SLC ( ... Effects of FTY720 and CsA on rat skin allograft survival (WKAH donor to F344 recipient). F344 rats with transplanted WKAH skin ... Rat allogeneic MLC. Allogeneic MLC was performed using nylon nonadherent spleen cells from F344 rats as responder cells and ... Effects of FTY720 and CsA on numbers of CD3+ T cells in peripheral blood of skin-allografted rats. F344 rats with transplanted ...
Markholst H, Andreasen B, Eastman S, Lernmark Å: Diabetes segregates as a single locus in crosses between inbred BB rats prone ... F344/F344, orange (5) DP/F344, and purple (6) DR/F344. P is the original recombinant rat with the heterozygous DP/F344 ... Introgression of F344 Rat Genomic DNA on BB Rat Chromosome 4 Generates Diabetes-Resistant Lymphopenic BB Rats. ... Introgression of F344 Rat Genomic DNA on BB Rat Chromosome 4 Generates Diabetes-Resistant Lymphopenic BB Rats ...
The DA rat strain was used to establish a lung exposure model. Five other inbred rat strains (PVG, PVG.1AV1, LEW, WF and F344) ... in naïve rats and in rats with induced allergic airway disease. The responses of two different inbred rat strains were compared ... only in DA rats. Sensitization of the rats induced a prominent OVA-specific-IgE and IgG response in the BN rat while DA rats ... DA rats were found to be higher responder compared to BN rats, both when it comes to responses in naïve and sensitized rats. ...
  • Leptin (1 mg/kg/d) or vehicle was administered systemically by miniosmotic pump in Fischer 344 rats either for 7 days (BrdU-labeling indices study) or 23 days (azoxymethane-induced colonic lesions study). (nih.gov)
  • Fischer 344 (F344) rats represent a strain that is frequently used as a model for fast aging. (frontiersin.org)
  • We made three Sprague-Dawley (SD) and one Fischer 344 (F344) transgenic rat models by pronuclear microinjection of DNA. (imgs.org)
  • A functional observational battery (FOB) was utilized to assess the effects of 3-day exposure to the formamidine pesticide amitraz in outbred Sprague-Dawley derived and inbred Fischer-344 derived (F344) rats (both from Charles River Laboratories), and in outbred Long-Evans rats obtained from two commercial suppliers (Charles River Breeding Laboratories and Blue Spruce Farms). (epa.gov)
  • The purpose of this investigation was to evaluate insulin-stimulated skeletal muscle glucose uptake in male Fischer 344 rats, age 6, 12, and 27 mo, fed either a sucrose (S: 66.6% sucrose, 17.6% protein, 6.4% fat) or sucrose-free (SF: 66.6% starch, 17.6% protein, 6.4% fat) diet for 3 mo. (elsevier.com)
  • We hypothesized that glucose utilization by skeletal muscle is less in cold-exposed older male versus female Fischer 344 (F344) rats and that this reduction may contribute to the poorer cold-exposed thermoregulatory ability of the older males. (elsevier.com)
  • Fischer (CDF) and Brown Norway (BN) rats, however, are susceptible to chronic infection and develop transmissible cysts in their brain and muscle tissue [2] , [3] . (prolekare.cz)
  • In the present study, we first investigated the chemopreventive potential of methylselenocysteine in the Fischer 344 (F344) rat. (aacrjournals.org)
  • Genetic contributions were assessed using three strains of male rats with different genetic backgrounds [Fischer-344 (F344), Sprague-Dawley (SD), Brown-Norway (BN)] maintained on a standard or high fat (HF) diet for 24 wk. (cdc.gov)
  • Male Fischer (F344) rats that develop benign interstitial testicular (Leydig cell) tumors (ITT) linked to low physiological levels of endogenous testosterone (T) and prevented by high levels of T, were mated with female Lobund-Wistar (LW) rats, a strain that develops prostate cancer (PC) linked to abnormally high levels of endogenous T and prevented by early T-deprivation. (aacrjournals.org)
  • Hybrids were free of overt and of microscopic biomarkers of PC, however a) a subset of hybrids (37%) developed overt PC following IV inoculation of mutagenic methylnitrosourea plus implants of exogenous testosterone propionate ,and b) like LW control rats, hybrids were susceptible to the unique hormone refractory PC (PAIII) transplanted cell, that was rejected by control Fischer rats. (aacrjournals.org)
  • Previously, we showed that despite similar body size, Fischer 344 (F344) rats have significantly different skeletal traits compared with Lewis (LEW) rats. (galileo-training.com)
  • In the current study, we performed an age-based comparison of proteasome function and composition of subunits and regulatory proteins in the neural retina and retinal pigment epithelium (RPE) in Fischer 344 rats. (umn.edu)
  • Protein expression and oxidation were evaluated in myosin and actin isolated from the soleus and semimembranosus muscles from young adult, old, and very old Fischer 344 rats. (umn.edu)
  • We have shown previously that the Fischer (F344) rat has lower GFR than the Lewis rat, and is more susceptible to renal injury induced by hypertension. (frontiersin.org)
  • Here, the Fischer (F344) strain is susceptible while Cyp1a1-Ren2 transgenic rats on the Lewis background are protected from renal injury. (frontiersin.org)
  • Although mouse, hamster, and rabbit models of the human N-acetylation polymorphism have been identified and characterized, many investigations of arylamine toxicity and carcinogenicity are carried out in the rat, particularly the Fischer 344 (F-344) inbred rat. (aspetjournals.org)
  • Methods Using immunohistochemical and behavioral techniques in adult male Fischer rats, the authors studied the involvement of brain stem opioidergic and gamma-aminobutyric acid-mediated (GABAergic) neurons in the N2O-induced antinociceptive effect using discrete microinjections of an opioid receptor antagonist or GABAergic activator into the periaqueductal gray area and pontine noradrenergic nuclei. (asahq.org)
  • There is evidence from quantitative electron microscopy studies of urinary bladder carcinomas induced by a chemical carcinogen in Fischer rats that decreased intercellular adhesion, mediated in part by intercellular junctions, does not contribute to the invasive potential of tumours. (elsevier.com)
  • Objective The present study assessed the effect of prolonged betamethasone use in ligature-induced periodontitis in adult Fischer-344 rats. (bvsalud.org)
  • Fischer-344 rats were exposed to 0.0, 0.3, 1.0, or 2.0 mg Cd/m3 as CdCl2 aerosol for 6 h/d, 5 d/wk, for 62 exposure days. (nih.gov)
  • Fischer rat thyroid epithelial cells (FRT) growing continuously in culture were infected with the Kirsten murine sarcoma virus KiMSV(KiMuLV) and found to produce this virus constitutively. (elsevier.com)
  • Male Fischer rats (SPF) of 32 weeks of age were housed in individual cages for 4 weeks. (elsevier.com)
  • Spontaneous pituitary tumors occurring in groups of 100 Sprague-Dawley (SD) and 100 Fischer 344 (F344) rats of each sex on a 2-year aging study were characterized by immunocytochemistry. (elsevier.com)
  • Young adult (3 months old) and aging (24 months old) Fischer rats were treated for 2 months with vehicle, or the potent PARP inhibitor INO-1001. (utmb.edu)
  • Topographical distribution of the IMP of urinary bladder epithelial cell membranes in normal Fischer rat bladder and noninvasive and invasive N-(4-(5-nitro-2-furyl)-2-thiazolyl)formamide (FANFT)-induced bladder tumors are shown to be significantly different. (elsevier.com)
  • Pauli, BU, Friedell, GH & Weinstein, RS 1978, ' Topography and numerical densities of intramembrane particles in chemical carcinogen-induced urinary bladder carcinomas in Fischer rats ', Laboratory Investigation , vol. 39, no. 6, pp. 565-573. (elsevier.com)
  • As a counterpart to this strategy, L-dopa administration (50 mg/kg) to adult male Fischer 344 rats with unilateral nigrostriatal lesions using 6-hydroxy-dopamine, and subsequent fetal mesencephalic grafts resulted in stunted size and neurite outgrowth, diminished tyrosine hydroxylase (TH) expression, diminished behavioral recovery, and diminished ability to reverse lesion-induced D2 receptor changes, compared with saline-treated rats with the same lesion and subsequent graft. (elsevier.com)
  • Inbred Fischer rats have greater HPA activation. (bvsalud.org)
  • Inbred Fischer rats produce greater amounts of the abovementioned substances, which has a direct effect on the nervous, connective, and epithelial tissues of the periodontium, facilitating the progression of ligatureinduced periodontitis 7-9 . (bvsalud.org)
  • The norepinephrine content of blood vessels in male Fischer 344 rats aged 6, 12, 20 and 27 months was measured by electrochemical detection after alumina extraction and high-performance liquid chromatography separation. (elsevier.com)
  • Handa, R & Duckles, SP 1987, ' Influence of age on norepinephrine content in arteries and veins of fischer 344 rats ', Neurobiology of Aging , vol. 8, no. 6, pp. 511-516. (elsevier.com)
  • As potential standards, the F344 inbred strain and an outbred stock of Long Evans were tested with three other inbred strains. (springer.com)
  • The inclusion of a 'standard strain or stock' in phenotyping protocols involving multiple inbred strains or lines of rats, mice and flies has obvious advantages by providing a reference point for inter-laboratory comparisons. (springer.com)
  • The DA rat strain was used to establish a lung exposure model. (wiley.com)
  • DRH strain rats were established by inbreeding a closed colony of Donryu rats continuously fed the chemical hepatocarcinogen 3′-methyl-4-dimethylaminoazobenzene for over 10 years. (aacrjournals.org)
  • For example, the inbred rat strain LEW has been shown to self-administer stimulant drugs more readily than the F344 strain. (drugabuse.gov)
  • The enriched rats of both strains showed less amphetamine self-administration, while the isolated rats of both strains were more prone to self-administration of amphetamine, with the IC condition causing even greater self-administration in the F344 strain than the LEW strain. (drugabuse.gov)
  • These genetic factors therefore seem to be dependent on the rat strain used in the cross, i.e., influenced by a differing genome background. (diabetesjournals.org)
  • A strain is inbred when it has undergone at least 20 generations of brother x sister or offspring x parent mating, at which point at least 98.6% of the loci in an individual of the strain will be homozygous, and each individual can be treated effectively as clones. (wikipedia.org)
  • Thus outbred strains of most laboratory animals are also available, where an outbred strain is a strain of an organism that is effectively wildtype in nature, where there is as little inbreeding as possible. (wikipedia.org)
  • One type of inbred strain that either has been altered, or naturally mutated so that it is different at a single locus. (wikipedia.org)
  • Such strains are useful in the analysis of variance within an inbred strain or between inbred strains because any differences would be due to the single genetic change, or to a difference in environmental conditions between two individuals of the same strain, One of the more specific uses of Drosophila inbred strains are the use of Gal4/UAS lines in research. (wikipedia.org)
  • Rat Strain and Stock Comparisons Using a Functional Observational Battery: Baseline Values and Effects of Amitraz. (epa.gov)
  • These findings indicated that WS/Shi is the most sensitive strain to NNM and may be the most suitable strain for use as a spontaneous metastatic model of HCC among the strains of rats examined in the present study. (cognizantcommunication.com)
  • Our results showed that, as in other strains, dietary supplementation with selenium (3 ppm) in the form of methylselenocysteine for 30 days following N -nitroso- N -methylurea (NMU) exposure reduced the incidence of mammary carcinogenesis by ∼60% in the F344 strain. (aacrjournals.org)
  • This study was performed to test whether a strongly photoresponsive rat strain (F344) and strongly nonphotoresponsive rat strain (HSD) have similar circadian urinary excretion profiles of the major metabolite of melatonin, 6-sulfatoxymelatonin (aMT6s), in long-day (L:D 16:8) and short-day (L:D 8:16) photoperiods. (jcircadianrhythms.com)
  • Urinary 24-hour aMT6s profiles were measured under L:D 8:16 and L:D 16:8 in young male laboratory rats of a strain known to be reproductively responsive to the short-day photoperiod (F344) and another known to be nonresponsive (HSD). (jcircadianrhythms.com)
  • A separate set of rats from each strain were allowed to recover from WF exposure until the end of the 24 wk period. (cdc.gov)
  • Generally, the exposome components of diet and WF exposure had the greater influence on the parameters measured compared to the changes associated with rat strain except for the body weight changes observed with the HF diet that were more pronounced in the inbred F344 and BN strains. (cdc.gov)
  • In F344 rats BBG caused a significant reduction in blood pressure and a decrease in renal vascular resistance, suggesting that P2X 7 receptor activation may enhance vasoconstrictor tone in this rat strain. (frontiersin.org)
  • Based upon these results, the F-344 inbred strain is designated a rapid acetylator phenotype, the WKY inbred strain is designated a slow acetylator phenotype, and F1 hybrids of the two parental strains are designated intermediate acetylator phenotype. (aspetjournals.org)
  • This strain, the F344 , was selected by Curtis and Dunning in 1920 at the Columbia University Institute for Cancer Research. (janvier-labs.com)
  • A deletion in the intergenic region upstream of Ednrb causes head spot in the rat strain KFRS4/Kyo. (kyoto-u.ac.jp)
  • We also developed a novel congenic rat strain harboring the Ctns ugl mutation on the F344 genetic background. (springer.com)
  • Fully differentiated rat thyroid epithelial cells (FRT-L cells) infected with another strain of the Kirsten murine sarcoma virus, the KiMSV(MolMuLV), were also transformed as demonstrated by the ability also of these cells to grow as carcinomas (after in vitro transformation) in syngeneic animals. (elsevier.com)
  • For example, oltipraz and related dithiolethiones are potent phase 2 inducers that protect against acute toxicity caused by acetaminophen, allyl alcohol, and aflatoxin in mice, hamsters, and rats, respectively. (aacrjournals.org)
  • To compare transgenic efficiency between rats and mice we first established procedures for superovulation and pseudopregnant recipient production. (imgs.org)
  • The efficiency of SD rat transgenesis is similar to inbred mice. (imgs.org)
  • This essay presents some practical advice and suggestions for those who wish to use mice and rats in experiments on the biology of aging. (afar.org)
  • This article is intended to convey some rules-of-thumb for investigators just starting to think about the design of experiments on aging using mice and rats. (afar.org)
  • In addition the word "mice" will be used throughout to mean "mice and rats," except in those cases where mice are different from rats. (afar.org)
  • Rats, like humans, are quite resistant to Toxoplasma infection when compared to mice. (prolekare.cz)
  • In this At a Glance poster review, Ellenbroek and Youn describe important differences between rats and mice that impact on their use as model organisms for brain disorders. (biologists.org)
  • Genetic mapping using collaborative cross mice (CC), a genetically diverse recombinant inbred mouse reference panel, offers a powerful tool to identify causal loci at a resolution under one mega base-pairs, with a relatively small cohort size. (biomedcentral.com)
  • The hippocampus can be extracted quickly and easily from rats and mice and slices remain viable for hours in oxygenated artificial cerebrospinal fluid. (meta.org)
  • This article outlines the procedures we use for preparing hippocampal slices from rats and transgenic mice for the study of synaptic alterations associated with brain aging and Alzheimer's disease (AD)(1-3). (meta.org)
  • Use of aged rats and AD model mice can present a unique set of challenges to researchers accustomed to using younger rats. (meta.org)
  • On the other hand, Sprague-Dawley rats showed the largest increases in the sensorimotor responses to stimuli. (epa.gov)
  • Additionally, changes in mRNA levels of genes involved in aflatoxin metabolism were measured in rat liver following a single dose of CDDO-Im. (aacrjournals.org)
  • Previous studies have identified Nat1 and Nat2 genes in the rat. (aspetjournals.org)
  • In this study, we identified and characterized a third rat N -acetyltransferase gene ( Nat3 ) consisting of a single open reading frame of 870 base pairs encoding a 290-amino acid protein, analogous to the previously identified human and rat N -acetyltransferase genes. (aspetjournals.org)
  • Gimap5 is a member of seven related genes located within 150 Kb on rat chromosome 4. (diabetesjournals.org)
  • A hybrid between two inbred strains can be used to cancel out deleterious recessive genes resulting in an increase in the mentioned areas. (wikipedia.org)
  • Nlrp1 genes from sensitive rat macrophages can confer sensitivity to this rapid cell death when expressed in Toxoplasma resistant rat macrophages. (prolekare.cz)
  • Our results further showed that the expression of Per2 and DBP mRNAs was significantly decreased in mammary tumors arising in rats on the selenium-enriched diet, but not in tumors of rats on the control diet, suggesting that selenium-induced elevation in the expression of circadian genes was incompatible with mammary carcinogenesis. (aacrjournals.org)
  • To identify a gene or genes regulating fracture risk at the femoral neck, we mapped quantitative trait loci (QTL) for femoral neck density and structure phenotypes using a 595 F2 progeny derived from the inbred F344 and LEW strains of rats. (galileo-training.com)
  • Two novel candidate genes, P2rx7 and P2rx4 , were identified, having a 7− and 3− fold increased expression in F344 rats. (frontiersin.org)
  • We give some examples of this in the present paper, while also highlighting that microarray gene expression studies reveal that HPA-axisand prolactin-related genes (among others) in the amygdala appear to be related with (or associated to) the coping style and anxiety/fearfulness responses of NIH-HS rats. (scirp.org)
  • Identification of candidate genes for generalized tonic-clonic seizures in Noda epileptic rat. (kyoto-u.ac.jp)
  • Fingerprint Dive into the research topics of 'Cloning of cDNAs from fetal rat liver encoding glutathione S-transferase Yc polypeptides. (dundee.ac.uk)
  • Blizard, D. A., Bailey, D. W. 1979 Genetic correlation between open-field activity and defecation: analysis with CXB recombinant-inbred strains Behav. (springer.com)
  • The results in this study suggest there is a link between the development of lung fibrosis and high cytotoxic cell responses and that there is a genetic influence, as there are variations in acute and late adverse reactions between rat strains in both timing and magnitude. (wiley.com)
  • In contrast, however, BioBreeding (BB) rat type 1 diabetes appears to be controlled by a limited number of genetic factors in inbred congenic BBDR.BBDP-(D4Mit6-D4Mit7)/Rhw (DR. lyp ) rats housed under specific pathogen-free conditions ( 7 - 9 ). (diabetesjournals.org)
  • Certain plants including the genetic model organism Arabidopsis thaliana naturally self-pollinate, which makes it quite easy to create inbred strains in the laboratory (other plants, including important genetic models such as maize require transfer of pollen from one flower to another). (wikipedia.org)
  • Inbreeding animals will sometimes lead to genetic drift. (wikipedia.org)
  • Linkage analyses of LEWxBN F2 progeny was previously used to map Toxoplasma resistance in rats to a single genetic locus, termed Toxo1 , within a 1.7-cM region of chromosome 10 [2] . (prolekare.cz)
  • The Rat Genome Database (RGD) is the most comprehensive site for genetic, genomic and phenotype data for Rattus norvegicus , a leading animal model for disease-, drug- and toxicity-related research. (biologists.org)
  • Using experimental models of rheumatoid arthritis, natural genetic polymorphisms associated with arthritis are identified and characterised in rats, bringing in new biological insights into arthritis in humans. (biologists.org)
  • Transferring a Tp53 -knockout allele from an outbred rat stock to the F344 inbred rat genetic background alters the spectrum of tumors, providing a model of early-onset brain and bone sarcomas. (biologists.org)
  • An accurate and high-resolution genetic map is critical for mapping complex traits, yet the resolution of the current rat genetic map is far lower than human and mouse, and has not been updated since the original Jensen-Seaman map in 2004. (g3journal.org)
  • 0.02 cM) by using 95,769 genetic markers and 870 informative meioses from a cohort of 528 heterogeneous stock (HS) rats. (g3journal.org)
  • Also for the first time, sex-specific rat genetic maps were generated, which revealed both genomewide and fine-scale variation in recombination rates between male and female rats. (g3journal.org)
  • Reanalysis of multiple quantitative trait loci (QTL) using the historical and refined rat genetic maps demonstrated marked changes to QTL localization, shape, and effect size. (g3journal.org)
  • As a resource to the rat research community, we have provided revised centimorgan positions for all physical positions within the rat genome and commonly used genetic markers for trait mapping, including 44,828 SSLP markers and the RATDIV genotyping array. (g3journal.org)
  • Collectively, this study provides a substantial improvement to the rat genetic map and an unprecedented resource for analysis of complex traits and recombination in the rat. (g3journal.org)
  • As such, the relatively low resolution of the current rat genetic map is a potential limitation for accurately mapping QTL in the rat. (g3journal.org)
  • Finally, reanalysis of historical QTL using the refined rat genetic maps revealed changes to QTL localization, shape, and effect size. (g3journal.org)
  • Genetic studies currently under way have thus far revealed that the genetically heterogeneous NIH-HS rat stock constitutes a unique tool for fine mapping of QTL (for multiple behavioural and biological complex traits) to megabase resolution levels, thus enabling candidate gene identification. (scirp.org)
  • About three decades ago Hansen and Spuhler raised the issue that most commonly used outbred laboratory rat stocks could have a rather narrow genetic ancestry [1]. (scirp.org)
  • Thus, with the purpose of overcoming the problem of too narrow and shared genetic ancestry in the available outbred rat stocks, Hansen and Spuhler [1] developed a more naturalistic, genetically heterogeneous rat stock which could hypothetically yield a broad-range distribution of responses to experimental conditions and could serve as a base population for selection studies. (scirp.org)
  • Also, a specific antibody response in sera of cholangiocyte-immunized rats was demonstrated by immunoblots against cholangiocyte proteins. (elsevier.com)
  • Methods: Bacteria S. aureus (ATCC #49775) and F98 and 9L glioma cells were injected stereotactically in the brains of F344 rats to form abscesses and tumors. (elsevier.com)
  • F344 rats had a total of 62 tumors with 26% in males and 36% in females. (elsevier.com)
  • Using several statistical methods that test IMP topography vis-a-vis the Poisson (random) hypothesis, it is demonstrated that IMP are mathematically randomly distributed in the large majority of plasma membranes of cells in normal rat bladder epithelium and in invasive N-(4-(5-nitro-2-furyl)-2-thiazolyl)formamide tumors. (elsevier.com)
  • Since norepinephrine in the blood vessel wall is predominantly localized to sympathetic nerve endings, the decline in norepinephrine content in most arteries of old rats may reflect a selective decrease in the density of sympathetic neurons or alternatively an age-related alteration in the metabolic properties of these sympathetic nerve endings. (elsevier.com)
  • Orotic acid, nucleotide-pool imbalance, and liver-tumor promotion: a possible mechanism for the mitoinhibitory effects of orotic acid in isolated rat hepatocytes. (biomedsearch.com)
  • We show that the triterpenoid, 1-[2-cyano-3-,12-dioxooleana-1,9(11)-dien-28-oyl]imidazole (CDDO-Im), is a highly potent chemopreventive agent that inhibits aflatoxin-induced tumorigenesis in rat liver. (aacrjournals.org)
  • The chemopreventive potency of CDDO-Im was evaluated by measuring inhibition of formation of putative preneoplastic lesions (glutathione S -transferase P positive foci) in the liver of rats exposed to aflatoxin B 1 . (aacrjournals.org)
  • Liver weight was highest in WS/Shi rats among the three strains examined. (cognizantcommunication.com)
  • Normal mammary tissue of rats fed a standardized diet showed little circadian oscillation relative to liver tissue. (aacrjournals.org)
  • Acetylator phenotype-dependent and -independent expression of arylamine N-acetyltransferase isozymes in rapid and slow acetylator inbred rat liver. (aspetjournals.org)
  • We partially characterized a new rat model of the N-acetylation polymorphism by determining expression of arylamine N-acetyltransferase activities in liver cytosols derived from adult male inbred F-344, WKY, and their F1 hybrid rat strains. (aspetjournals.org)
  • Partial purification of rat liver cytosols from the three strains resulted in identification of two N-acetyltransferase isozymes. (aspetjournals.org)
  • Cloning of cDNAs from fetal rat liver encoding glutathione S-transferase Yc polypeptides. (dundee.ac.uk)
  • Fetal rat liver possesses substantial levels of glutathione S-transferase (GST) activity toward aflatoxin B1-8,9-epoxide. (dundee.ac.uk)
  • Immunoblotting and enzyme assays have shown that liver from adult female rats contains about 10-fold greater levels of Yc2 than is found in liver from adult male rats. (dundee.ac.uk)
  • This sex-specific expression of Yc2 in adult rat liver may contribute to the relative insensitivity of female rats to aflatoxin B1. (dundee.ac.uk)
  • Academic transgenic facilities may hesitate to provide transgenic rat services because anecdotal evidence suggests that the production of transgenic rats is less efficient than transgenic mouse production. (imgs.org)
  • Live-cell imaging was used to quantify patterns of reporter gene expression in dispersed lactotrophic cells or intact pituitary tissue from bacterial artificial chromosome (BAC) transgenic rats in which a large prolactin genomic fragment directed expression of luciferase or destabilised enhanced green fluorescent protein (d2EGFP). (edgehill.ac.uk)
  • Such gene-by-environment interactions can be explored by studying rats that have been specifically bred to be genetically susceptible or resistant to drug use. (drugabuse.gov)
  • Whereas exposure of virgin female rats to a variety of carcinogens during puberty results in close to 100% incidence of mammary carcinomas in many susceptible strains, animals fed with garlic grown in selenium-enriched soil showed dramatic reductions in tumor incidence ( 2 - 4 ). (aacrjournals.org)
  • In contrast, when data were expressed relative to total tissue weight (nmol/min), skeletal muscle glucose utilization was significantly higher in male than in female rats. (elsevier.com)
  • Thus, our hypothesis that reduced skeletal muscle glucose utilization contributes to the blunted thermoregulatory ability of older male versus female F344 rats is negated. (elsevier.com)
  • McDonald, RB, Murtagh, CM & Horwitz, BA 1994, ' Age and gender effects on glucose utilization in skeletal muscle and brown adipose tissue of cold-exposed rats ', Proceedings of the Society for Experimental Biology and Medicine , vol. 207, no. 1, pp. 102-109. (elsevier.com)
  • Our approach to dissect the genetics of spontaneous diabetes in the BB rat was to initially develop lines congenic for lyp through introgression of the BBDP lyp locus onto BBDR to generate DR. lyp/lyp rats ( 7 ). (diabetesjournals.org)
  • This Review describes the most recent advances in the field of systems genetics, focusing on the rat. (biologists.org)
  • The relative affinities of arylamine carcinogens such as 4-aminobiphenyl, N -hydroxy-4-aminobiphenyl, and 2-aminofluorene for N - and O -acetylation via recombinant rat Nat3 were comparable with recombinant rat Nat1 and higher than for recombinant rat Nat2. (aspetjournals.org)
  • Inbred strains of male F344 and WKAH rats were purchased from Charles River Japan (Atsugi, Kanagawa, Japan) and Japan SLC (Hamamatsu, Shizuoka, Japan), respectively. (jimmunol.org)
  • Howard Jacob describes some of the key moments and breakthroughs in his remarkable career, and the path that led him from his research roots in cardiovascular disease and rat physiology to becoming Director of a clinical genomic sequencing program. (biologists.org)
  • Genome-wide linkage analysis for the diabetes phenotype have identified additional loci after crossing different inbred BB rats with DA rats ( Iddm3 on chromosome 18) ( 17 ), WF rats ( Iddm4 and Iddm5 on chromosomes 4 and 13, respectively) ( 18 , 19 ), and SHR rats ( Iddm6 on the X chromosome) ( 20 ). (diabetesjournals.org)
  • We report here that rat macrophages from different inbred strains also vary in sensitivity to Toxoplasma induced lysis. (prolekare.cz)
  • However, glucose utilization per IBAT depot (nmol/min) was significantly less in older male than in female rats, and reflected the fact that IBAT weight of older males was more than 50% lower than that of comparably aged females. (elsevier.com)
  • To identify signaling pathways involved in carcinogenesis that are also modulated by methylselenocysteine, we compared the global gene expression profiles in mammary tissues from pubescent female rats maintained on a selenium-supplemented (3 ppm) diet with those on a standardized diet after N -nitroso- N -methylurea. (aacrjournals.org)
  • As a group, female rats survived significantly longer than the males. (nih.gov)
  • This study investigates in rat colonic mucosa (1) the effects of hyperleptinemia on epithelial cell proliferation and development of aberrant crypts, earliest preneoplastic lesions, and (2) whether luminal leptin affects cell proliferation. (nih.gov)
  • Role of H-ras in the malignant progression of rat tracheal epithelial cells. (nih.gov)
  • The effect of an activated H-ras oncogene on the progression of neoplasia was studied in transformed rat tracheal epithelial cells. (nih.gov)
  • However, this was not seen in another ras-containing line, suggesting the importance of alternative pathways in malignant progression of rat tracheal epithelial cells. (nih.gov)
  • labeling indices were higher in proximal colon than in pair-fed control rats (P = 0.006) but unaffected in distal colon. (nih.gov)
  • Control rats showed only resident alveolar macrophages (AM) in the BALF with no apoptosis. (elsevier.com)
  • control rats were immunized with bovine serum albumin (BSA) or hepatocytes. (elsevier.com)
  • With a novel focus on the immune system this paper investigate whether late phase pulmonary effects developed in rats exposed to the nitrogen mustard melphalan are linked to the acute responses and whether the reactions are genetically regulated. (wiley.com)
  • We initiated a large-scale bidirectional selection experiment in a genetically heterogeneous rat population (N/NIH stock, n = 152) to develop lines of low response trainers (LRT) and high response trainers (HRT) as a contrasting animal model system. (physiology.org)
  • In fact, at least two rat lines genetically selected for excessive alcohol drinking, namely P and AA rats, have been shown to be more sensitive to the psychotropic effects of cocaine and to have an innate higher predisposition to its consumption. (deltasocietyaustralia.com.au)
  • What can we learn on rodent fearfulness/anxiety from the genetically heterogeneous NIH-HS rat stock? (scirp.org)
  • The "National Institutes of Health" genetically heterogeneous (NIH-HS) rat stock was created in the 1980s through an eight-way cross of as much as possible separate inbred rat strains (i.e. the MR/N, WN/N, WKY/N, M520/N, F344/N, ACI/N, BN/SsN and BUF/N strains) which were readily available at that time. (scirp.org)
  • Hansen and Spuhler [1] developed a more naturalistic, genetically heterogeneous rat stock with the aim of optimizing the distribution of genotypic frequencies and recombination and under the hypothesis that the NIH-HS stock could yield a broad-range distribution of responses (broader than commonly used laboratory rat strains) to experimental conditions, and thus serve as a base population for selection studies. (scirp.org)
  • So, with the goal of optimizing the distribution of genotypic frequencies and recombination within the laboratory rat population, the "National Institutes of Health-N/NIH- Genetically Heterogeneous Rat Stock" (hereafter NIHHS rats) was formed through an eight-way cross of as much as possible separate inbred strains which were readily available. (scirp.org)
  • Given the previously reported role of Per2 as a tumor suppressor, these observations suggest that Per2 is an important target of methylselenocysteine during chemoprevention in N -nitroso- N -methylurea-induced rat mammary carcinogenesis, and for the first time provide a link between chemoprevention and circadian rhythm. (aacrjournals.org)
  • Two disparate strains of inbred rats were selected, each developing spontaneously up to age 24 months, differences in tumor type, in organ site, and in optimal level of endogenous testosterone for tumor development. (aacrjournals.org)
  • In noninvasive rat bladder carcinomas, IMP are in a lattice-like arrangement in half of the tumor cells and randomly distributed in the remainder. (elsevier.com)
  • By contrast, mammary tissue of rats maintained on the selenium-enriched diet showed a progressive, time-dependent increase in the expression of circadian gene Per2 and circadian-regulated transcription factor DBP . (aacrjournals.org)
  • Intravenous infusion of mesenchymal stem cells inhibits intracranial hemorrhage after recombinant tissue plasminogen activator therapy for transient middle cerebral artery occlusion in rats. (kyoto-u.ac.jp)
  • Spontaneous diabetes in the BB rat may therefore be controlled, in part, by a diabetogenic factor(s), perhaps unrelated to the Gimap5 mutation on rat chromosome 4. (diabetesjournals.org)
  • Rats with a novel dopamine D1 receptor mutation, which causes reduced membrane Drd1 expression, display impaired social cognition, although their exploratory and anxiety-like behaviours are unaffected. (biologists.org)
  • Tremor dominant Kyoto (Trdk) rats carry a missense mutation in the gene encoding the SK2 subunit of small-conductance Ca2+-activated K+ channel. (kyoto-u.ac.jp)
  • Regional brain incorporation of a radiolabeled unsaturated fatty acid, [1-14C]arachidonic acid (14C-AA), was measured in awake rats following unilateral lesioning of the nucleus basalis magnocellularis (NBM). (muscimol.xyz)
  • Unexpectedly, in azoxymethane-treated rats, leptin significantly inhibited aberrant crypt foci formation in the middle and distal colon compared with controls (P = 0.006). (nih.gov)
  • Methods and Results- KRP-203 significantly prolonged skin or heart allograft survival of a minor histocompatibility complex (mHC)-disparate (LEW to F344) rat combination. (ahajournals.org)
  • Although estimated glucose utilization in IBAT (nmol/min/g) isolated from cold-exposed rats was significantly greater than that in brown fat isolated from non-cold-exposed animals, there was no main effect of age or gender. (elsevier.com)
  • Four-week administration of NNM resulted in a significantly higher BrdU-labeling index of hepatocytes in WS/Shi rats than in the other strains. (cognizantcommunication.com)
  • However, for some other arylamine substrates, levels of N-acetyltransferase activity did not differ significantly between the rat strains. (aspetjournals.org)
  • Results Jac-E and Jac-O of groups B and S were not significantly different, but they differed significantly from those of group C. Conclusion Prolonged use of betamethasone did not affect the progression of induced periodontitis in rats. (bvsalud.org)
  • The results of this experiment were as follows: (1) The total leukocyte counts in the blood of the rats after the 1st trial was significantly higher than that before the 1st trial. (elsevier.com)
  • Prolonged use of betamethasone did not affect the progression of induced periodontitis in rats. (bvsalud.org)
  • Whey protein may also be beneficial, as shown by both animal and human studies, and experimental data have demonstrated that the major component bovine lactoferrin (bLF), inhibits colon carcinogenesis in the post-initiation stage in male F344 rats treated with azoxymethane (AOM) without any overt toxicity. (nih.gov)
  • It is known that organic forms of selenium inhibit chemically induced rat mammary carcinogenesis, although the molecular basis remains to be elucidated. (aacrjournals.org)
  • Transgenic rat models for mutagenesis and carcinogenesis. (kyoto-u.ac.jp)
  • Transplantation of GDAs into stab-wound lesions of the dorsal column white matter pathways of adult rat spinal cord (Figure 1a-c) resulted in the growth of the majority of the cut ascending dorsal column axons into the lesion center (Figures 2 and 3a), with 66% of these axons extending further beyond the lesion site into adjacent white matter (Figures 2 and 3a,b,e,f). (nih.gov)
  • FaOH and FaDOH have previously demonstrated a chemopreventive effect on precursor lesions of colorectal cancer (CRC) in azoxymethane (AOM)-induced rats. (bvsalud.org)
  • Phenotypic analysis of F344- Ctns ugl rats indicated that the incidence of urinary glucose was 100% in both males and females at around 40 weeks of age, and marked cystine accumulation was observed in the tissues, as well as remarkable renal lesions and cystine crystals in the lysosomes of the renal cortex. (springer.com)
  • Right-sided lesions were produced in 3-month-old, male rats by stereotaxic injection of 10 micrograms ibotenic acid. (muscimol.xyz)
  • Rat Nat3 amino acid sequence was 68.6 and 67.2% identical to human NAT1 and NAT2, respectively. (aspetjournals.org)
  • Rat Nat2 and human NAT1 amino acid sequences both contain Phe125, Arg127, Tyr129, which is predictive of their similar arylamine substrate selectivities. (aspetjournals.org)
  • Rats were sacrificed, and various skeletal muscles and IBAT were removed and immediately frozen in liquid N 2 for subsequent analysis of [ 14 C]-2DGP content. (elsevier.com)
  • In the semimembranosus, actin content was stable, but myosin exhibited decreased content in muscles from very old rats, resulting in a decrease in the myosin-to-actin ratio. (umn.edu)
  • This study examined gene-by-environment interactions in susceptibility to drug use by raising LEW and F344 rats in varied environmental conditions. (drugabuse.gov)
  • We investigated the susceptibility of three inbred strains of rats to the hepatocarcinogen, N-nitrosomorpholine (NNM), to establish a spontaneous metastatic model of hepatocellular carcinoma (HCC). (cognizantcommunication.com)
  • Rat strains have been previously shown to vary in their susceptibility to this parasite. (prolekare.cz)
  • The HXB/BXH recombinant inbred (RI) rat collection, developed from the SHR/Ola and BN-Lx congenic parental strains [5] - [7] , with opposing LT sensitivities, was used to map anthrax toxin susceptibility to a single locus at 55.8-58.1 Mb of rat chromosome 10. (prolekare.cz)
  • The SC rats differed according to genotype, with SC LEW rats taking more amphetamine than SC F344 rats. (drugabuse.gov)
  • Inbred strains (also called inbred lines, or rarely for animals linear animals) are individuals of a particular species which are nearly identical to each other in genotype due to long inbreeding. (wikipedia.org)
  • Transplantation of astrocytes derived from embryonic glial-restricted precursors (GRPs) promoted robust axon growth and restoration of locomotor function after acute transection injuries of the adult rat spinal cord. (nih.gov)
  • The present study was designed to investigate the potency and safety of KRP-203 on allograft survival against both acute and chronic rejection in rat skin and heart transplantation. (ahajournals.org)
  • Rats, Inbred F344" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (harvard.edu)
  • Then all rats were immobilized by stainless wire mesh for 6hours daily for 3days. (elsevier.com)
  • Our data demonstrate that introgression of a 33-Mb region of the F344 genome, proximal to the mutated Gimap5 gene, renders the rat diabetes resistant despite being lymphopenic. (diabetesjournals.org)
  • Application of genome editing technologies in rats for human disease models. (kyoto-u.ac.jp)
  • Rat Genome and Model Resources. (kyoto-u.ac.jp)
  • From engineering to editing the rat genome. (kyoto-u.ac.jp)
  • For example, it has been demonstrated that heterogeneous rats selected for low and high impulsivity also differ in the vulnerability to develop cocaine abuse, with only the latter showing compulsive drug-taking despite aversive consequences. (deltasocietyaustralia.com.au)
  • Breeding of inbred strains is often towards specific phenotypes of interest such as behavioural traits like alcohol preference or physical traits like aging, or they can be selected for traits that make them easier to use in experiments like being easy to use in transgenic experiments. (wikipedia.org)
  • One of the key strengths of using inbred strains as a model is that strains are readily available for whatever study one is performing and that there are resources such as the Jackson Laboratory, and Flybase, where one can look up strains with specific phenotypes or genotypes from among inbred lines, recombinant lines, and coisogenic strains. (wikipedia.org)
  • The question of whether young male HSD rats would have reproductive responses to constant dark or to supplemental melatonin injections was also tested. (jcircadianrhythms.com)
  • In other experiments, young HSD rats failed to suppress reproduction or reduce body weight in response to either constant dark or twice-daily supplemental melatonin injections. (jcircadianrhythms.com)
  • Cell proliferation of rat bladder urothelium induced by nicotine is suppressed by the NADPH oxidase inhibitor, apocynin. (illumina.com)
  • Rat hindlimbs were perfused at a rate of 10 ml · min -1 with a modified Krebs Henseleit buffer containing bovine red blood cells (hematocrit: 40%) and 5.85 mmole · L -1 glucose along with 358 pmoles · L -1 followed by 3580 pmoles · L -1 insulin. (elsevier.com)
  • Large amounts of urine with a strong odor, a possible indicator of diabetes mellitus, were frequently observed, and urinary glucose was detected in both male and female LEA/Tohm rats. (springer.com)
  • In an intercross between F1(BBDP x F344) rats, we identified a rat with a recombination event on chromosome 4, allowing us to fix 33 Mb of F344 between D4Rat253 and D4Rhw6 in the congenic DR. lyp rat line. (diabetesjournals.org)
  • In this Review, we discuss the advantages and disadvantages of the rat for studies of experimental spinal cord injury and summarize the knowledge gained from such studies. (biologists.org)
  • The effects of lead and inhibitors of ferrochelatase, the iron insertion step of heme synthesis, on the conversion of 5-aminolevulinic acid to zinc protoporphyrin, protoporphyrin and heme were compared in rat and chick embryo hepatocyte cultures. (nih.gov)
  • Along the last decade, in a series of studies we have phenotypically characterized the NIH-HS rat stock (a colony exists at our laboratory since 2004) for their anxiety/fearfulness profiles (using a battery of both unconditioned and conditioned tests/tasks), as well as regarding their stress-induced hormonal responses, coping style under inescapable stress and spatial learning ability. (scirp.org)
  • abstract = "The oleic acid (OA) model of acute lung injury in rats is characterized by a massive and rapid influx of polymorphonuclear neutrophils (PMN) within 1 h, with a peak inflammatory response at 4 h and resolution by 72 h. (elsevier.com)
  • abstract = "A study was conducted on the changes of physiological function in rats due to immobilization stress. (elsevier.com)
  • As a point of reference, oltipraz, an established modulator of aflatoxin metabolism in humans, is 100-fold weaker than CDDO-Im in this rat antitumorigenesis model. (aacrjournals.org)
  • Offspring homozygous for the F344 allele ( f/f ) between D4Rat253 and D4Rhw6 were lymphopenic (85 of 85, 100%) but did not develop diabetes (0 of 85). (diabetesjournals.org)
  • Identification of rat lines with desirable superovulation characteristics and birth rates may further improve the efficiency of rat transgenesis in the future. (imgs.org)
  • Analysis of endocrine effects in rats after 15 days of treatment revealed a strong reduction of the weights of prostates and seminal vesicles and a significant rise of testosterone serum levels as a result of the interference with central feedback mechanisms. (uni-regensburg.de)
  • Effect of diet and occupational exposure in different rat strains on serum biomarkers and peripheral blood mononuclear cell telomere length: development of an animal model to examine the exposome. (cdc.gov)