Pemphigoid, Benign Mucous Membrane: A chronic blistering disease with predilection for mucous membranes and less frequently the skin, and with a tendency to scarring. It is sometimes called ocular pemphigoid because of conjunctival mucous membrane involvement.Mucous Membrane: An EPITHELIUM with MUCUS-secreting cells, such as GOBLET CELLS. It forms the lining of many body cavities, such as the DIGESTIVE TRACT, the RESPIRATORY TRACT, and the reproductive tract. Mucosa, rich in blood and lymph vessels, comprises an inner epithelium, a middle layer (lamina propria) of loose CONNECTIVE TISSUE, and an outer layer (muscularis mucosae) of SMOOTH MUSCLE CELLS that separates the mucosa from submucosa.Mouth Mucosa: Lining of the ORAL CAVITY, including mucosa on the GUMS; the PALATE; the LIP; the CHEEK; floor of the mouth; and other structures. The mucosa is generally a nonkeratinized stratified squamous EPITHELIUM covering muscle, bone, or glands but can show varying degree of keratinization at specific locations.Pemphigus: Group of chronic blistering diseases characterized histologically by ACANTHOLYSIS and blister formation within the EPIDERMIS.Mouth DiseasesLip DiseasesDesmoglein 3: A desmosomal cadherin that is an autoantigen in the acquired skin disorder PEMPHIGUS VULGARIS.Pemphigoid, Bullous: A chronic and relatively benign subepidermal blistering disease usually of the elderly and without histopathologic acantholysis.Membranes: Thin layers of tissue which cover parts of the body, separate adjacent cavities, or connect adjacent structures.Membrane Lipids: Lipids, predominantly phospholipids, cholesterol and small amounts of glycolipids found in membranes including cellular and intracellular membranes. These lipids may be arranged in bilayers in the membranes with integral proteins between the layers and peripheral proteins attached to the outside. Membrane lipids are required for active transport, several enzymatic activities and membrane formation.Cell Membrane: The lipid- and protein-containing, selectively permeable membrane that surrounds the cytoplasm in prokaryotic and eukaryotic cells.Rhinosporidiosis: Chronic, localized granulomatous infection of mucocutaneous tissues, especially the NOSE, and characterized by HYPERPLASIA and the development of POLYPS. It is found in humans and other animals and is caused by the mesomycetozoean organism RHINOSPORIDIUM SEEBERI.Intracellular Membranes: Thin structures that encapsulate subcellular structures or ORGANELLES in EUKARYOTIC CELLS. They include a variety of membranes associated with the CELL NUCLEUS; the MITOCHONDRIA; the GOLGI APPARATUS; the ENDOPLASMIC RETICULUM; LYSOSOMES; PLASTIDS; and VACUOLES.Stomatitis: INFLAMMATION of the soft tissues of the MOUTH, such as MUCOSA; PALATE; GINGIVA; and LIP.Membrane Potentials: The voltage differences across a membrane. For cellular membranes they are computed by subtracting the voltage measured outside the membrane from the voltage measured inside the membrane. They result from differences of inside versus outside concentration of potassium, sodium, chloride, and other ions across cells' or ORGANELLES membranes. For excitable cells, the resting membrane potentials range between -30 and -100 millivolts. Physical, chemical, or electrical stimuli can make a membrane potential more negative (hyperpolarization), or less negative (depolarization).Gingival DiseasesOral Ulcer: A loss of mucous substance of the mouth showing local excavation of the surface, resulting from the sloughing of inflammatory necrotic tissue. It is the result of a variety of causes, e.g., denture irritation, aphthous stomatitis (STOMATITIS, APHTHOUS); NOMA; necrotizing gingivitis (GINGIVITIS, NECROTIZING ULCERATIVE); TOOTHBRUSHING; and various irritants. (From Jablonski, Dictionary of Dentistry, 1992, p842)Stevens-Johnson Syndrome: Rare cutaneous eruption characterized by extensive KERATINOCYTE apoptosis resulting in skin detachment with mucosal involvement. It is often provoked by the use of drugs (e.g., antibiotics and anticonvulsants) or associated with PNEUMONIA, MYCOPLASMA. It is considered a continuum of Toxic Epidermal Necrolysis.Membranes, Artificial: Artificially produced membranes, such as semipermeable membranes used in artificial kidney dialysis (RENAL DIALYSIS), monomolecular and bimolecular membranes used as models to simulate biological CELL MEMBRANES. These membranes are also used in the process of GUIDED TISSUE REGENERATION.Rhinosporidium: A genus in the order Dermocystidium, class MESOMYCETOZOEA. It causes RHINOSPORIDIOSIS in MAMMALS and BIRDS.Lichen Planus, Oral: Oral lesions accompanying cutaneous lichen planus or often occurring alone. The buccal mucosa, lips, gingivae, floor of the mouth, and palate are usually affected (in a descending order of frequency). Typically, oral lesions consist of radiating white or gray, velvety, threadlike lines, arranged in a reticular pattern, at the intersection of which there may be minute, white, elevated dots or streaks (Wickham's striae). (Jablonski, Illustrated Dictionary of Dentistry)Skin Diseases, Genetic: Diseases of the skin with a genetic component, usually the result of various inborn errors of metabolism.Skin Diseases, Vesiculobullous: Skin diseases characterized by local or general distributions of blisters. They are classified according to the site and mode of blister formation. Lesions can appear spontaneously or be precipitated by infection, trauma, or sunlight. Etiologies include immunologic and genetic factors. (From Scientific American Medicine, 1990)Erythema Multiforme: A skin and mucous membrane disease characterized by an eruption of macules, papules, nodules, vesicles, and/or bullae with characteristic "bull's-eye" lesions usually occurring on the dorsal aspect of the hands and forearms.Lipoid Proteinosis of Urbach and Wiethe: An autosomal recessive disorder characterized by glassy degenerative thickening (hyalinosis) of SKIN; MUCOSA; and certain VISCERA. This disorder is caused by mutation in the extracellular matrix protein 1 gene (ECM1). Clinical features include hoarseness and skin eruption due to widespread deposition of HYALIN.Candidiasis, Chronic Mucocutaneous: A clinical syndrome characterized by development, usually in infancy or childhood, of a chronic, often widespread candidiasis of skin, nails, and mucous membranes. It may be secondary to one of the immunodeficiency syndromes, inherited as an autosomal recessive trait, or associated with defects in cell-mediated immunity, endocrine disorders, dental stomatitis, or malignancy.Conjunctival DiseasesGranuloma, Pyogenic: A disorder of the skin, the oral mucosa, and the gingiva, that usually presents as a solitary polypoid capillary hemangioma often resulting from trauma. It is manifested as an inflammatory response with similar characteristics to those of a granuloma.Eye Diseases: Diseases affecting the eye.Lichen Planus: An inflammatory, pruritic disease of the skin and mucous membranes, which can be either generalized or localized. It is characterized by distinctive purplish, flat-topped papules having a predilection for the trunk and flexor surfaces. The lesions may be discrete or coalesce to form plaques. Histologically, there is a "saw-tooth" pattern of epidermal hyperplasia and vacuolar alteration of the basal layer of the epidermis along with an intense upper dermal inflammatory infiltrate composed predominantly of T-cells. Etiology is unknown.Erythrocyte Membrane: The semi-permeable outer structure of a red blood cell. It is known as a red cell 'ghost' after HEMOLYSIS.Membrane Fluidity: The motion of phospholipid molecules within the lipid bilayer, dependent on the classes of phospholipids present, their fatty acid composition and degree of unsaturation of the acyl chains, the cholesterol concentration, and temperature.Acantholysis: Separation of the prickle cells of the stratum spinosum of the epidermis, resulting in atrophy of the prickle cell layer. It is seen in diseases such as pemphigus vulgaris (see PEMPHIGUS) and DARIER DISEASE.Impetigo: A common superficial bacterial infection caused by STAPHYLOCOCCUS AUREUS or group A beta-hemolytic streptococci. Characteristics include pustular lesions that rupture and discharge a thin, amber-colored fluid that dries and forms a crust. This condition is commonly located on the face, especially about the mouth and nose.Desmoglein 1: A desmosomal cadherin that is an autoantigen in the acquired skin disorder PEMPHIGUS FOLIACEUS.Conjunctiva: The mucous membrane that covers the posterior surface of the eyelids and the anterior pericorneal surface of the eyeball.Skin: The outer covering of the body that protects it from the environment. It is composed of the DERMIS and the EPIDERMIS.Blister: Visible accumulations of fluid within or beneath the epidermis.Nasal Mucosa: The mucous lining of the NASAL CAVITY, including lining of the nostril (vestibule) and the OLFACTORY MUCOSA. Nasal mucosa consists of ciliated cells, GOBLET CELLS, brush cells, small granule cells, basal cells (STEM CELLS) and glands containing both mucous and serous cells.Scleritis: Refers to any inflammation of the sclera including episcleritis, a benign condition affecting only the episclera, which is generally short-lived and easily treated. Classic scleritis, on the other hand, affects deeper tissue and is characterized by higher rates of visual acuity loss and even mortality, particularly in necrotizing form. Its characteristic symptom is severe and general head pain. Scleritis has also been associated with systemic collagen disease. Etiology is unknown but is thought to involve a local immune response. Treatment is difficult and includes administration of anti-inflammatory and immunosuppressive agents such as corticosteroids. Inflammation of the sclera may also be secondary to inflammation of adjacent tissues, such as the conjunctiva.Laryngeal Diseases: Pathological processes involving any part of the LARYNX which coordinates many functions such as voice production, breathing, swallowing, and coughing.Cell Membrane Permeability: A quality of cell membranes which permits the passage of solvents and solutes into and out of cells.Basement Membrane: A darkly stained mat-like EXTRACELLULAR MATRIX (ECM) that separates cell layers, such as EPITHELIUM from ENDOTHELIUM or a layer of CONNECTIVE TISSUE. The ECM layer that supports an overlying EPITHELIUM or ENDOTHELIUM is called basal lamina. Basement membrane (BM) can be formed by the fusion of either two adjacent basal laminae or a basal lamina with an adjacent reticular lamina of connective tissue. BM, composed mainly of TYPE IV COLLAGEN; glycoprotein LAMININ; and PROTEOGLYCAN, provides barriers as well as channels between interacting cell layers.Skin DiseasesInfectious Disease Transmission, Patient-to-Professional: The transmission of infectious disease or pathogens from patients to health professionals or health care workers. It includes transmission via direct or indirect exposure to bacterial, fungal, parasitic, or viral agents.Autoantibodies: Antibodies that react with self-antigens (AUTOANTIGENS) of the organism that produced them.Dog Diseases: Diseases of the domestic dog (Canis familiaris). This term does not include diseases of wild dogs, WOLVES; FOXES; and other Canidae for which the heading CARNIVORA is used.Membrane Transport Proteins: Membrane proteins whose primary function is to facilitate the transport of molecules across a biological membrane. Included in this broad category are proteins involved in active transport (BIOLOGICAL TRANSPORT, ACTIVE), facilitated transport and ION CHANNELS.Plasma Cells: Specialized forms of antibody-producing B-LYMPHOCYTES. They synthesize and secrete immunoglobulin. They are found only in lymphoid organs and at sites of immune responses and normally do not circulate in the blood or lymph. (Rosen et al., Dictionary of Immunology, 1989, p169 & Abbas et al., Cellular and Molecular Immunology, 2d ed, p20)Membrane Glycoproteins: Glycoproteins found on the membrane or surface of cells.Rabbits: The species Oryctolagus cuniculus, in the family Leporidae, order LAGOMORPHA. Rabbits are born in burrows, furless, and with eyes and ears closed. In contrast with HARES, rabbits have 22 chromosome pairs.Lipid Bilayers: Layers of lipid molecules which are two molecules thick. Bilayer systems are frequently studied as models of biological membranes.Occupational Exposure: The exposure to potentially harmful chemical, physical, or biological agents that occurs as a result of one's occupation.Dogs: The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065)Mitochondrial Membranes: The two lipoprotein layers in the MITOCHONDRION. The outer membrane encloses the entire mitochondrion and contains channels with TRANSPORT PROTEINS to move molecules and ions in and out of the organelle. The inner membrane folds into cristae and contains many ENZYMES important to cell METABOLISM and energy production (MITOCHONDRIAL ATP SYNTHASE).Time Factors: Elements of limited time intervals, contributing to particular results or situations.Intestinal Mucosa: Lining of the INTESTINES, consisting of an inner EPITHELIUM, a middle LAMINA PROPRIA, and an outer MUSCULARIS MUCOSAE. In the SMALL INTESTINE, the mucosa is characterized by a series of folds and abundance of absorptive cells (ENTEROCYTES) with MICROVILLI.Microscopy, Electron: Microscopy using an electron beam, instead of light, to visualize the sample, thereby allowing much greater magnification. The interactions of ELECTRONS with specimens are used to provide information about the fine structure of that specimen. In TRANSMISSION ELECTRON MICROSCOPY the reactions of the electrons that are transmitted through the specimen are imaged. In SCANNING ELECTRON MICROSCOPY an electron beam falls at a non-normal angle on the specimen and the image is derived from the reactions occurring above the plane of the specimen.Protein Transport: The process of moving proteins from one cellular compartment (including extracellular) to another by various sorting and transport mechanisms such as gated transport, protein translocation, and vesicular transport.Synaptic Membranes: Cell membranes associated with synapses. Both presynaptic and postsynaptic membranes are included along with their integral or tightly associated specializations for the release or reception of transmitters.Fatal Outcome: Death resulting from the presence of a disease in an individual, as shown by a single case report or a limited number of patients. This should be differentiated from DEATH, the physiological cessation of life and from MORTALITY, an epidemiological or statistical concept.Occupational Diseases: Diseases caused by factors involved in one's employment.Cell Line: Established cell cultures that have the potential to propagate indefinitely.Liposomes: Artificial, single or multilaminar vesicles (made from lecithins or other lipids) that are used for the delivery of a variety of biological molecules or molecular complexes to cells, for example, drug delivery and gene transfer. They are also used to study membranes and membrane proteins.Protein Binding: The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments.Calcium: A basic element found in nearly all organized tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes.Models, Biological: Theoretical representations that simulate the behavior or activity of biological processes or diseases. For disease models in living animals, DISEASE MODELS, ANIMAL is available. Biological models include the use of mathematical equations, computers, and other electronic equipment.Cell Fractionation: Techniques to partition various components of the cell into SUBCELLULAR FRACTIONS.Immunosuppressive Agents: Agents that suppress immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-CELLS or by inhibiting the activation of HELPER CELLS. While immunosuppression has been brought about in the past primarily to prevent rejection of transplanted organs, new applications involving mediation of the effects of INTERLEUKINS and other CYTOKINES are emerging.Protein Structure, Tertiary: The level of protein structure in which combinations of secondary protein structures (alpha helices, beta sheets, loop regions, and motifs) pack together to form folded shapes called domains. Disulfide bridges between cysteines in two different parts of the polypeptide chain along with other interactions between the chains play a role in the formation and stabilization of tertiary structure. Small proteins usually consist of only one domain but larger proteins may contain a number of domains connected by segments of polypeptide chain which lack regular secondary structure.Carrier Proteins: Transport proteins that carry specific substances in the blood or across cell membranes.Extraembryonic Membranes: The thin layers of tissue that surround the developing embryo. There are four extra-embryonic membranes commonly found in VERTEBRATES, such as REPTILES; BIRDS; and MAMMALS. They are the YOLK SAC, the ALLANTOIS, the AMNION, and the CHORION. These membranes provide protection and means to transport nutrients and wastes.Hydrogen-Ion Concentration: The normality of a solution with respect to HYDROGEN ions; H+. It is related to acidity measurements in most cases by pH = log 1/2[1/(H+)], where (H+) is the hydrogen ion concentration in gram equivalents per liter of solution. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)Detergents: Purifying or cleansing agents, usually salts of long-chain aliphatic bases or acids, that exert cleansing (oil-dissolving) and antimicrobial effects through a surface action that depends on possessing both hydrophilic and hydrophobic properties.Immunoglobulin G: The major immunoglobulin isotype class in normal human serum. There are several isotype subclasses of IgG, for example, IgG1, IgG2A, and IgG2B.Escherichia coli: A species of gram-negative, facultatively anaerobic, rod-shaped bacteria (GRAM-NEGATIVE FACULTATIVELY ANAEROBIC RODS) commonly found in the lower part of the intestine of warm-blooded animals. It is usually nonpathogenic, but some strains are known to produce DIARRHEA and pyogenic infections. Pathogenic strains (virotypes) are classified by their specific pathogenic mechanisms such as toxins (ENTEROTOXIGENIC ESCHERICHIA COLI), etc.Electrophoresis, Polyacrylamide Gel: Electrophoresis in which a polyacrylamide gel is used as the diffusion medium.Endoplasmic Reticulum: A system of cisternae in the CYTOPLASM of many cells. In places the endoplasmic reticulum is continuous with the plasma membrane (CELL MEMBRANE) or outer membrane of the nuclear envelope. If the outer surfaces of the endoplasmic reticulum membranes are coated with ribosomes, the endoplasmic reticulum is said to be rough-surfaced (ENDOPLASMIC RETICULUM, ROUGH); otherwise it is said to be smooth-surfaced (ENDOPLASMIC RETICULUM, SMOOTH). (King & Stansfield, A Dictionary of Genetics, 4th ed)Phosphatidylcholines: Derivatives of phosphatidic acids in which the phosphoric acid is bound in ester linkage to a choline moiety. Complete hydrolysis yields 1 mole of glycerol, phosphoric acid and choline and 2 moles of fatty acids.Cells, Cultured: Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.Golgi Apparatus: A stack of flattened vesicles that functions in posttranslational processing and sorting of proteins, receiving them from the rough ENDOPLASMIC RETICULUM and directing them to secretory vesicles, LYSOSOMES, or the CELL MEMBRANE. The movement of proteins takes place by transfer vesicles that bud off from the rough endoplasmic reticulum or Golgi apparatus and fuse with the Golgi, lysosomes or cell membrane. (From Glick, Glossary of Biochemistry and Molecular Biology, 1990)Mutation: Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.Bacterial Proteins: Proteins found in any species of bacterium.Microscopy, Fluorescence: Microscopy of specimens stained with fluorescent dye (usually fluorescein isothiocyanate) or of naturally fluorescent materials, which emit light when exposed to ultraviolet or blue light. Immunofluorescence microscopy utilizes antibodies that are labeled with fluorescent dye.Freeze Fracturing: Preparation for electron microscopy of minute replicas of exposed surfaces of the cell which have been ruptured in the frozen state. The specimen is frozen, then cleaved under high vacuum at the same temperature. The exposed surface is shadowed with carbon and platinum and coated with carbon to obtain a carbon replica.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Molecular Weight: The sum of the weight of all the atoms in a molecule.Recombinant Fusion Proteins: Recombinant proteins produced by the GENETIC TRANSLATION of fused genes formed by the combination of NUCLEIC ACID REGULATORY SEQUENCES of one or more genes with the protein coding sequences of one or more genes.Cell Membrane Structures: Structures which are part of the CELL MEMBRANE or have cell membrane as a major part of their structure.Potassium: An element in the alkali group of metals with an atomic symbol K, atomic number 19, and atomic weight 39.10. It is the chief cation in the intracellular fluid of muscle and other cells. Potassium ion is a strong electrolyte that plays a significant role in the regulation of fluid volume and maintenance of the WATER-ELECTROLYTE BALANCE.Microvilli: Minute projections of cell membranes which greatly increase the surface area of the cell.Temperature: The property of objects that determines the direction of heat flow when they are placed in direct thermal contact. The temperature is the energy of microscopic motions (vibrational and translational) of the particles of atoms.Subcellular Fractions: Components of a cell produced by various separation techniques which, though they disrupt the delicate anatomy of a cell, preserve the structure and physiology of its functioning constituents for biochemical and ultrastructural analysis. (From Alberts et al., Molecular Biology of the Cell, 2d ed, p163)Mitochondria: Semiautonomous, self-reproducing organelles that occur in the cytoplasm of all cells of most, but not all, eukaryotes. Each mitochondrion is surrounded by a double limiting membrane. The inner membrane is highly invaginated, and its projections are called cristae. Mitochondria are the sites of the reactions of oxidative phosphorylation, which result in the formation of ATP. They contain distinctive RIBOSOMES, transfer RNAs (RNA, TRANSFER); AMINO ACYL T RNA SYNTHETASES; and elongation and termination factors. Mitochondria depend upon genes within the nucleus of the cells in which they reside for many essential messenger RNAs (RNA, MESSENGER). Mitochondria are believed to have arisen from aerobic bacteria that established a symbiotic relationship with primitive protoeukaryotes. (King & Stansfield, A Dictionary of Genetics, 4th ed)Amino Acid Sequence: The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.Biological Transport, Active: The movement of materials across cell membranes and epithelial layers against an electrochemical gradient, requiring the expenditure of metabolic energy.Endocytosis: Cellular uptake of extracellular materials within membrane-limited vacuoles or microvesicles. ENDOSOMES play a central role in endocytosis.Microscopy, Confocal: A light microscopic technique in which only a small spot is illuminated and observed at a time. An image is constructed through point-by-point scanning of the field in this manner. Light sources may be conventional or laser, and fluorescence or transmitted observations are possible.Cytoplasm: The part of a cell that contains the CYTOSOL and small structures excluding the CELL NUCLEUS; MITOCHONDRIA; and large VACUOLES. (Glick, Glossary of Biochemistry and Molecular Biology, 1990)Erythrocytes: Red blood cells. Mature erythrocytes are non-nucleated, biconcave disks containing HEMOGLOBIN whose function is to transport OXYGEN.Models, Molecular: Models used experimentally or theoretically to study molecular shape, electronic properties, or interactions; includes analogous molecules, computer-generated graphics, and mechanical structures.Binding Sites: The parts of a macromolecule that directly participate in its specific combination with another molecule.Membrane Potential, Mitochondrial: The voltage difference, normally maintained at approximately -180mV, across the INNER MITOCHONDRIAL MEMBRANE, by a net movement of positive charge across the membrane. It is a major component of the PROTON MOTIVE FORCE in MITOCHONDRIA used to drive the synthesis of ATP.Purple Membrane: Functionally and structurally differentiated, purple-pigmented regions of the cytoplasmic membrane of some strains of Halobacterium halobium. The membrane develops under anaerobic conditions and is made almost entirely of the purple pigment BACTERIORHODOPSINS. (From Singleton & Sainsbury Dictionary of Microbiology and Molecular Biology, 2d ed)Ion Channels: Gated, ion-selective glycoproteins that traverse membranes. The stimulus for ION CHANNEL GATING can be due to a variety of stimuli such as LIGANDS, a TRANSMEMBRANE POTENTIAL DIFFERENCE, mechanical deformation or through INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS.Sodium: A member of the alkali group of metals. It has the atomic symbol Na, atomic number 11, and atomic weight 23.Protein Conformation: The characteristic 3-dimensional shape of a protein, including the secondary, supersecondary (motifs), tertiary (domains) and quaternary structure of the peptide chain. PROTEIN STRUCTURE, QUATERNARY describes the conformation assumed by multimeric proteins (aggregates of more than one polypeptide chain).Solubility: The ability of a substance to be dissolved, i.e. to form a solution with another substance. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)Treatment Outcome: Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.Cattle: Domesticated bovine animals of the genus Bos, usually kept on a farm or ranch and used for the production of meat or dairy products or for heavy labor.Base Sequence: The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.Fluorescent Antibody Technique: Test for tissue antigen using either a direct method, by conjugation of antibody with fluorescent dye (FLUORESCENT ANTIBODY TECHNIQUE, DIRECT) or an indirect method, by formation of antigen-antibody complex which is then labeled with fluorescein-conjugated anti-immunoglobulin antibody (FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT). The tissue is then examined by fluorescence microscopy.Fluorescent Dyes: Agents that emit light after excitation by light. The wave length of the emitted light is usually longer than that of the incident light. Fluorochromes are substances that cause fluorescence in other substances, i.e., dyes used to mark or label other compounds with fluorescent tags.Adenosine Triphosphate: An adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter.Electric Conductivity: The ability of a substrate to allow the passage of ELECTRONS.Nictitating Membrane: A fold of the mucous membrane of the CONJUNCTIVA in many animals. At rest, it is hidden in the medial canthus. It can extend to cover part or all of the cornea to help clean the CORNEA.Bruch Membrane: The inner layer of CHOROID, also called the lamina basalis choroideae, located adjacent to the RETINAL PIGMENT EPITHELIUM; (RPE) of the EYE. It is a membrane composed of the basement membranes of the choriocapillaris ENDOTHELIUM and that of the RPE. The membrane stops at the OPTIC NERVE, as does the RPE.Permeability: Property of membranes and other structures to permit passage of light, heat, gases, liquids, metabolites, and mineral ions.Signal Transduction: The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.Protein Structure, Secondary: The level of protein structure in which regular hydrogen-bond interactions within contiguous stretches of polypeptide chain give rise to alpha helices, beta strands (which align to form beta sheets) or other types of coils. This is the first folding level of protein conformation.Octoxynol: Nonionic surfactant mixtures varying in the number of repeating ethoxy (oxy-1,2-ethanediyl) groups. They are used as detergents, emulsifiers, wetting agents, defoaming agents, etc. Octoxynol-9, the compound with 9 repeating ethoxy groups, is a spermatocide.Microscopy, Immunoelectron: Microscopy in which the samples are first stained immunocytochemically and then examined using an electron microscope. Immunoelectron microscopy is used extensively in diagnostic virology as part of very sensitive immunoassays.Cytosol: Intracellular fluid from the cytoplasm after removal of ORGANELLES and other insoluble cytoplasmic components.Exocytosis: Cellular release of material within membrane-limited vesicles by fusion of the vesicles with the CELL MEMBRANE.Cricetinae: A subfamily in the family MURIDAE, comprising the hamsters. Four of the more common genera are Cricetus, CRICETULUS; MESOCRICETUS; and PHODOPUS.Cholesterol: The principal sterol of all higher animals, distributed in body tissues, especially the brain and spinal cord, and in animal fats and oils.Peptides: Members of the class of compounds composed of AMINO ACIDS joined together by peptide bonds between adjacent amino acids into linear, branched or cyclical structures. OLIGOPEPTIDES are composed of approximately 2-12 amino acids. Polypeptides are composed of approximately 13 or more amino acids. PROTEINS are linear polypeptides that are normally synthesized on RIBOSOMES.Recombinant Proteins: Proteins prepared by recombinant DNA technology.Sequence Homology, Amino Acid: The degree of similarity between sequences of amino acids. This information is useful for the analyzing genetic relatedness of proteins and species.Retrospective Studies: Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.Diffusion: The tendency of a gas or solute to pass from a point of higher pressure or concentration to a point of lower pressure or concentration and to distribute itself throughout the available space. Diffusion, especially FACILITATED DIFFUSION, is a major mechanism of BIOLOGICAL TRANSPORT.Endosomes: Cytoplasmic vesicles formed when COATED VESICLES shed their CLATHRIN coat. Endosomes internalize macromolecules bound by receptors on the cell surface.Blotting, Western: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.Phosphatidylethanolamines: Derivatives of phosphatidic acids in which the phosphoric acid is bound in ester linkage to an ethanolamine moiety. Complete hydrolysis yields 1 mole of glycerol, phosphoric acid and ethanolamine and 2 moles of fatty acids.Vacuoles: Any spaces or cavities within a cell. They may function in digestion, storage, secretion, or excretion.Cloning, Molecular: The insertion of recombinant DNA molecules from prokaryotic and/or eukaryotic sources into a replicating vehicle, such as a plasmid or virus vector, and the introduction of the resultant hybrid molecules into recipient cells without altering the viability of those cells.Escherichia coli Proteins: Proteins obtained from ESCHERICHIA COLI.Phosphatidylserines: Derivatives of phosphatidic acids in which the phosphoric acid is bound in ester linkage to a serine moiety. Complete hydrolysis yields 1 mole of glycerol, phosphoric acid and serine and 2 moles of fatty acids.Transfection: The uptake of naked or purified DNA by CELLS, usually meaning the process as it occurs in eukaryotic cells. It is analogous to bacterial transformation (TRANSFORMATION, BACTERIAL) and both are routinely employed in GENE TRANSFER TECHNIQUES.Porins: Porins are protein molecules that were originally found in the outer membrane of GRAM-NEGATIVE BACTERIA and that form multi-meric channels for the passive DIFFUSION of WATER; IONS; or other small molecules. Porins are present in bacterial CELL WALLS, as well as in plant, fungal, mammalian and other vertebrate CELL MEMBRANES and MITOCHONDRIAL MEMBRANES.Kinetics: The rate dynamics in chemical or physical systems.Green Fluorescent Proteins: Protein analogs and derivatives of the Aequorea victoria green fluorescent protein that emit light (FLUORESCENCE) when excited with ULTRAVIOLET RAYS. They are used in REPORTER GENES in doing GENETIC TECHNIQUES. Numerous mutants have been made to emit other colors or be sensitive to pH.Microsomes: Artifactual vesicles formed from the endoplasmic reticulum when cells are disrupted. They are isolated by differential centrifugation and are composed of three structural features: rough vesicles, smooth vesicles, and ribosomes. Numerous enzyme activities are associated with the microsomal fraction. (Glick, Glossary of Biochemistry and Molecular Biology, 1990; from Rieger et al., Glossary of Genetics: Classical and Molecular, 5th ed)Unilamellar Liposomes: Single membrane vesicles, generally made of PHOSPHOLIPIDS.Electrophysiology: The study of the generation and behavior of electrical charges in living organisms particularly the nervous system and the effects of electricity on living organisms.Spectrometry, Fluorescence: Measurement of the intensity and quality of fluorescence.Immunoblotting: Immunologic method used for detecting or quantifying immunoreactive substances. The substance is identified by first immobilizing it by blotting onto a membrane and then tagging it with labeled antibodies.Fetal Membranes, Premature Rupture: Spontaneous tearing of the membranes surrounding the FETUS any time before the onset of OBSTETRIC LABOR. Preterm PROM is membrane rupture before 37 weeks of GESTATION.Receptors, Cell Surface: Cell surface proteins that bind signalling molecules external to the cell with high affinity and convert this extracellular event into one or more intracellular signals that alter the behavior of the target cell (From Alberts, Molecular Biology of the Cell, 2nd ed, pp693-5). Cell surface receptors, unlike enzymes, do not chemically alter their ligands.Tympanic Membrane: An oval semitransparent membrane separating the external EAR CANAL from the tympanic cavity (EAR, MIDDLE). It contains three layers: the skin of the external ear canal; the core of radially and circularly arranged collagen fibers; and the MUCOSA of the middle ear.Descemet Membrane: A layer of the cornea. It is the basal lamina of the CORNEAL ENDOTHELIUM (from which it is secreted) separating it from the CORNEAL STROMA. It is a homogeneous structure composed of fine collagenous filaments, and slowly increases in thickness with age.Chlorides: Inorganic compounds derived from hydrochloric acid that contain the Cl- ion.COS Cells: CELL LINES derived from the CV-1 cell line by transformation with a replication origin defective mutant of SV40 VIRUS, which codes for wild type large T antigen (ANTIGENS, POLYOMAVIRUS TRANSFORMING). They are used for transfection and cloning. (The CV-1 cell line was derived from the kidney of an adult male African green monkey (CERCOPITHECUS AETHIOPS).)Cytoskeleton: The network of filaments, tubules, and interconnecting filamentous bridges which give shape, structure, and organization to the cytoplasm.HeLa Cells: The first continuously cultured human malignant CELL LINE, derived from the cervical carcinoma of Henrietta Lacks. These cells are used for VIRUS CULTIVATION and antitumor drug screening assays.Extracorporeal Membrane Oxygenation: Application of a life support system that circulates the blood through an oxygenating system, which may consist of a pump, a membrane oxygenator, and a heat exchanger. Examples of its use are to assist victims of smoke inhalation injury, respiratory failure, and cardiac failure.Transport Vesicles: Vesicles that are involved in shuttling cargo from the interior of the cell to the cell surface, from the cell surface to the interior, across the cell or around the cell to various locations.Lysosomes: A class of morphologically heterogeneous cytoplasmic particles in animal and plant tissues characterized by their content of hydrolytic enzymes and the structure-linked latency of these enzymes. The intracellular functions of lysosomes depend on their lytic potential. The single unit membrane of the lysosome acts as a barrier between the enzymes enclosed in the lysosome and the external substrate. The activity of the enzymes contained in lysosomes is limited or nil unless the vesicle in which they are enclosed is ruptured. Such rupture is supposed to be under metabolic (hormonal) control. (From Rieger et al., Glossary of Genetics: Classical and Molecular, 5th ed)Protein Sorting Signals: Amino acid sequences found in transported proteins that selectively guide the distribution of the proteins to specific cellular compartments.
Lymphoma in animals
Cats who are also infected with FeLV often present with pale mucous membranes due to anemia. Anemia is a common problem in all ... Complete cure is rare with lymphoma and treatment tends to be palliative, but long remission times are possible with ... cats with lymphoma, but hypercalcemia is rare. Diagnosis is similar to dogs, except cats should be tested for FeLV and FIV. It ...
In rare cases exposure may cause sensitization of the mucous membrane and eruptions of the skin. The irritant effect of ethyl ... Ethyl acetate is an irritant of the conjunctiva and mucous membrane of the respiratory tract. Animal experiments have shown ... These azeotropes are broken by pressure swing distillation or membrane distillation. Ethyl acetate is used primarily as a ... Traces of rare-earth and alkali metals are beneficial to the process. Byproducts of the dehydrogenation include diethyl ether, ...
Sometimes there is a semi-circular fold of mucous membrane at the opening of the appendix. This valve of the vermiform appendix ... In very rare cases (laparotomies for suspected appendicitis have given a frequency of 1 in 100,000), the appendix may not be ... In rare cases, adenomas are also present. Appendicitis is a condition characterized by inflammation of the appendix. Pain often ...
It has been suggested that transmission may very rarely occur via an aerosol through mucous membranes; and that transmission in ... However, non-bite transmission of rabies is very rare, and aerosol transmission has never been well documented in the natural ... Transmission between humans is extremely rare, although it can happen through organ transplants, or through bites.[citation ...
It may form flat, broad, whitish, wart-like lesions known as condyloma latum on mucous membranes. All of these lesions harbor ... Rare manifestations include liver inflammation, kidney disease, joint inflammation, periostitis, inflammation of the optic ... mucous membranes, and lymph nodes. There may be a symmetrical, reddish-pink, non-itchy rash on the trunk and extremities, ... the spirochete is able to pass through intact mucous membranes or compromised skin. It is thus transmissible by kissing near a ...
White blood cell
... is a rare group of blistering autoimmune diseases that affect the skin and mucous membranes. The name is derived from the Greek ... Definitive diagnosis requires examination of a skin or mucous membrane biopsy by a dermatopathologist or oral pathologist. The ... Intraorally it resembles the more common diseases lichen planus and mucous membrane pemphigoid. ... as lesions can affect the eyes and mucous membrane of the oral cavity. ...
It gains entrance through breaks in the skin, or it can cross the epithelial cell layer of mucous membranes. The organism ... The pharyngeal syndrome is rare. It starts after infection of pharyngeal tissue, and buboes in the neck region can occur. LGV ... Inoculation at the mucous lining of external sex organs (penis and vagina) can lead to the inguinal syndrome named after the ... In developed nations, it was considered rare before 2003. However, a recent outbreak in the Netherlands among gay men has led ...
Acral lentiginous melanoma
It is also found on mucous membranes. It is the most common form of melanoma diagnosed amongst Asian and sub-Saharan African ... Although acral lentiginous melanoma is rare in people with lighter skin types, it is the most common subtype in people with ... This occurs at the membrane of the skin (outer layers). The pathogenesis of acral lentiginous melanoma remains unknown at this ...
... dust and salts are very irritating to the eyes and mucous membranes, and moderately irritating to skin. Breathing the ... Although it belongs to the rare-earth metals, neodymium is not rare at all. Its abundance in the Earth's crust is about 38 mg/ ... Although neodymium is classed as a rare earth, it is a fairly common element, no rarer than cobalt, nickel, or copper, and is ... "Prices of Rare Earth Metals Declining Sharply". The New York Times. November 17, 2011. Rare Earths. Archive United States ...
Signs that a horse has been poisoned include yellow mucous membranes, depression, and lack of coordination. There is no ... Besides the fact that ragwort is very attractive to such a vast array of insects, some of these are very rare indeed. Of the 30 ... In short, ragwort is an exclusive food source for ten rare or threatened insect species, including the Cinnabar moth (Tyria ... documented cases of proven poisoning are rare. Horses do not normally eat fresh ragwort due to its bitter taste. The result, if ...
Equine encephalosis virus
Mucous membrane pemphigoid, an autoimmune reaction to the epithelial basement membrane, causes desquamation/ulceration of the ... Aphthous stomatitis and local trauma are very common causes of oral ulceration; the many other possible causes are all rare in ... The mucous membrane lining of the mouth is thinner than the skin, and easily damaged by mechanical, thermal (heat/cold), ... A mouth ulcer is an ulcer that occurs on the mucous membrane of the oral cavity. Mouth ulcers are very common, occurring in ...
A local anesthetic is often given to anesthetise the mucous membranes of the pharynx, larynx, and trachea. The patient is ... Laryngospasm is a rare complication but may sometimes require tracheal intubation. Patients with tumors or significant bleeding ... sometimes due to swelling of the mucous membranes of the airways. Endoscopy Rick Daniels (15 June 2009). Delmar's Guide to ...
... and mucous membranes, purple or red striae (the weight gain in Cushing's syndrome stretches the skin, which is thin and ... Cushing's disease is rare; a Danish study found an incidence of less than one case per million people per year. However, ... Although rare, Cushing's syndrome can also be due to the use of medroxyprogesterone acetate. In this form of Cushing's, the ... In rare cases, Cushing's can cause hypocalcemia. The excess cortisol may also affect other endocrine systems and cause, for ...
Hereditary hemorrhagic telangiectasia
12: 333-7. Weber FP (1907). "Multiple hereditary developmental angiomata (telangiectases) of the skin and mucous membranes ... Hereditary hemorrhagic telangiectasia (HHT), also known as Osler-Weber-Rendu disease and Osler-Weber-Rendu syndrome, is a rare ... mucous membranes, and often in organs such as the lungs, liver, and brain. It may lead to nosebleeds, acute and chronic ... associated with multiple telangiectases of the skin and mucous membranes". Bull. Johns Hopkins Hosp. ...
... mucous membranes (mouth, nasal membranes, GI tract), thyroid gland, and breast tissue. While the hamartomas are benign, people ... Cowden syndrome (also known as Cowden's disease and sometimes as multiple hamartoma syndrome) is a rare autosomal dominant ... noncancerous growths that are most commonly found on the skin and mucous membranes (such as the lining of the mouth, nose, and ... Additional signs and symptoms of Cowden syndrome can include an enlarged head (macrocephaly), a rare noncancerous brain tumor ...
EBOV is thought to infect humans through contact with mucous membranes or skin breaks. After infection, endothelial cells ( ... Contact between gorilla groups is rare, suggesting that transmission among gorilla groups is unlikely, and that outbreaks ... Bleeding from mucous membranes or from sites of needle punctures has been reported in 40-50% of cases. This may cause ... Virions bud off from the cell, gaining their envelopes from the cellular membrane from which they bud. The mature progeny ...
Mucous. membrane. *Aphthous stomatitis. *oral candidiasis. *lichen planus. *leukoplakia. *pemphigus vulgaris. *mucous membrane ... True cysts are rare in those with acne and the term severe nodular acne is now the preferred terminology. ... Acne can be a feature of rare genetic disorders such as Apert's syndrome. Severe acne may be associated with XYY syndrome.[ ... since rare harms from topical retinoids are not ruled out, they are not recommended for use during pregnancy due to persistent ...
That is, oral candidiasis is a mycosis (yeast/fungal infection) of Candida species on the mucous membranes of the mouth. ... This refers to a group of rare syndromes characterized by chronic candidal lesions on the skin, in the mouth and on other ... the organisms must be capable of adhering to the epithelial surface of the mucous membrane lining the mouth. This adhesion ... mucous membranes (i.e., a secondary oral candidiasis). These include Localized chronic mucocutaneous candidiasis, diffuse ...
The skin consists of a thin outer epidermis with mucous cells and sensory cells, and a connective tissue dermis consisting ... which is mostly suspended from the roof of the mantle cavity by numerous membranes. The tract consists of a crop, where the ... and so fossils are relatively rare. Octopuses, squids and cuttlefish belong to the clade Coleoidea. They are known as "soft- ... "8-Foot Octopus Wrestles Diver Off California Coast, Rare Encounter Caught on Camera". International Business Times ...
White blood cell
... and gums are tightly connected by a fold of mucous membrane called the philtrum, which runs from the tip of the nose to the ... A few rare species have also been found in northern Africa. The most basal of the adapiforms include the genera Cantius ... which is rare in simians, is fairly common in lemurs. Strepsirrhines spend a considerable amount of time grooming each ...
Vocal cord cyst
... through the thyrohyoid membrane, thyroid cartilage, or cricothyroid membrane. After VFSI, patients are recommended to take ... Sub-epithelial cysts (also known as mucous retention cysts) are closed lesions that occur from a build-up of tissue on the ... Signs and symptoms of vocal fold cysts may remain stable or increase over time. In rare cases it is also possible for ... They can result from the blockage of a mucous gland's excretory duct. In this case, they are sometimes referred to as ...
The only parts of the body that Kyrle disease do not form are the palms, soles, and mucous membranes. Lesions may heal ... Kyrle disease is a rare disease unless there is a high count of patients with chronic renal failure. The disease seems to be ... All in all, since Kyrle disease is relatively rare, more cases need to be studied and analyzed in order to understand the ...
The cartilage and mucous membrane of the primary bronchi are similar to those in the trachea. They are lined with respiratory ... Bronchial atresia is a rare congenital disorder that can have a varied appearance. A bronchial atresia is a defect in the ... The mucous membrane also undergoes a transition from ciliated pseudostratified columnar epithelium to simple cuboidal ...
One observer wrote, "One of the most striking of the complications was hemorrhage from mucous membranes, especially from the ... Encephalitis is a rare but not unheard of, and can occur in the elderly and present as confusion and slurred speech. ... The vRNA and viral core proteins leave the nucleus and enter this membrane protrusion (step 6). The mature virus buds off from ... the cell in a sphere of host phospholipid membrane, acquiring hemagglutinin and neuraminidase with this membrane coat (step 7). ...
Evolution of mammals
These are lined with mucous membranes that warm and moisten inhaled air and extract heat and moisture from exhaled air. An ... For many years, fossils of Mesozoic mammals and their immediate ancestors were very rare and fragmentary; but, since the mid- ... The first fully terrestrial vertebrates were amniotes - their eggs had internal membranes that allowed the developing embryo to ... The times of origin are difficult to know, because vertebrate fossils from the late Carboniferous are very rare, and therefore ...
By days 12-15, the first visible lesions - small reddish spots called enanthem - appeared on mucous membranes of the mouth, ... the condition was extremely rare but less lethal, with one case series showing a 66.7% death rate. ... A rash developed on the skin 24 to 48 hours after lesions on the mucous membranes appeared. Typically the macules first ... Hemorrhagic smallpox was a severe form accompanied by extensive bleeding into the skin, mucous membranes, and gastrointestinal ...
Mucous. membrane. *Aphthous stomatitis. *oral candidiasis. *lichen planus. *leukoplakia. *pemphigus vulgaris. *mucous membrane ... "Dermatofibroma , Genetic and Rare Diseases Information Center (GARD) - an NCATS Program". rarediseases.info.nih.gov. Retrieved ... from rare malignant fibrohistocytic tumours like dermatofibrosarcoma protuberans. ...
The fumes from cyanoacrylate are a vaporized form of the cyanoacrylate monomer that irritate the sensitive mucous membranes of ... On rare occasions, inhalation may trigger asthma. There is no singular measurement of toxicity for all cyanoacrylate adhesives ... the respiratory tract (i.e., eyes, nose, throat, and lungs). They are immediately polymerized by the moisture in the membranes ...
... is a chronic inflammatory and immune mediated disease that affects the skin, nails, hair, and mucous membranes.[1 ... "Orphanet: Rare Diseases". Orphanet. Retrieved June 3, 2016.. *^ "Cicatricial Alopecia Research Foundation". www.carfintl.org. ... Mucous membrane pemphigoid and other autoimmune blistering diseases may present with oral erosions and desquamative gingivitis ... This is a rare variant of lichen planus. Pigmented. This morphology is characterized by hyperpigmented, dark-brown macules in ...
... may cause ulceration on other mucosal surfaces in addition to the mouth such as the conjunctiva or the genital mucous membranes ... The name stands for "mouth and genital ulcers with inflamed cartilage" (relapsing polychondritis). PFAPA syndrome is a rare ... It tends to be rare in other countries such as the United States and the United Kingdom. MAGIC syndrome is a possible variant ... which develop into ulcers that are covered with a yellow-grey fibrinous membrane that can be scraped away. A reddish "halo" ...
Rabies in animals
... saliva or through mucous membranes and fresh wounds. The virus can incubate from one day up to over a year before any ... Despite natural infection of rabbits being rare, they are particularly vulnerable to the rabies virus; rabbits were used to ... the rare white-winged vampire bat, as well as two abundant species of fruit bats: the Seba's short-tailed bat and the Jamaican ...
Mucous. membrane. *Aphthous stomatitis. *oral candidiasis. *lichen planus. *leukoplakia. *pemphigus vulgaris. *mucous membrane ... Rarer complications of disseminated chickenpox include myocarditis, hepatitis, and glomerulonephritis. Hemorrhagic ... Necrotizing fasciitis is also a rare complication. ...
Mucus also covers the olfactory epithelium, which contains mucous membranes that produce and store mucus and olfactory glands ... Hyperosmia is a rare condition typified by an abnormally heightened sense of smell. Like vision and hearing, the olfactory ... The primary components of the layers of epithelial tissue are the mucous membranes, olfactory glands, olfactory neurons, and ...
Health effects of tobacco
... the adherent white plaques or patches on the mucous membranes of the oral cavity, including the tongue. ... "MEDLINEplus: Smoking Cuts Risk of Rare Cancer". Retrieved 8 September 2014.. *^ a b "The Tobacco Reference Guide". Archived ... Prior to World War I, lung cancer was considered to be a rare disease, which most physicians would never see during their ... lung cancer was considered to be a rare disease prior to World War I and was perceived as something most physicians would never ...
Irritation of mucous membranes. Hydrogen peroxide is an irritant and cytotoxic. Hydrogen peroxide with concentrations of ... Porphyria: A rare metabolic disorder where the body struggles to metabolise porphyria which leads to accumulation or the ... be corrosive to mucous membranes and cause burning sensation to the skin. Chemical burns can commonly occur whilst ... irritation and discolouration of the mucous membranes may occur if a high concentration of oxidising agent comes in to contact ...
Mucous membrane pemphigoid | DermNet NZ
Benign mucous membrane pemphigoid, Mucosynechia atrophic bullous dermatitis, Scarring pemphigoid, Cicatricial pemphigoid. ... Brunsting Perry cicatricial pemphigoid is a rare variant in which localised crops of recurrent blisters arise within urticarial ... What is mucous membrane pemphigoid?. Mucous membrane pemphigoid is an autoimmune disease that is characterised by blistering ... Who gets mucous membrane pemphigoid?. Mucous membrane pemphigoid is predominantly a disease of the elderly with a peak ...
Stevens Johnson Syndrome - NYEE
Mucous Membrane Pemphigoid Treatment Market Report Explored in Latest Research - PharmiWeb.com
Mucous membrane pemphigoid is a group of rare and chronic autoimmune diseases which are characterized by blistering on the ... Mucous membranes of mouth, nose, throat, and eye are often affected by the mucous membrane pemphigoid. In June 2018, FDA ... Mucous membranes of mouth, nose, throat, and eye are often affected by the mucous membrane pemphigoid. In June 2018, FDA ... The incidence of mucous membrane pemphigoid varies widely, for example, the incidence of mucous membrane pemphigoid U.K. is 1 ...
Medical Xpress - mucous membrane
Promacta approval expanded to kids with rare blood disorder. (HealthDay)-U.S. Food and Drug Administration approval of the drug ... Children who develop asthma or allergies have an altered immune response to intestinal bacteria in the mucous membranes even ... A genetic modification in the mucous membrane of the esophagus, the Barrett esophagus, can lead to esophageal cancer. If ... Almost all infections make us sick by getting past our first line of defense - the sticky mucous surfaces that line our mouths ...
Hydrogen Peroxide Mucous Membrane : Uses, Side Effects, Interactions, Pictures, Warnings & Dosing - WebMD
Congenital fibrinogen deficiency: MedlinePlus Medical Encyclopedia
Congenital fibrinogen deficiency is a very rare, inherited blood disorder in which the blood does not clot normally. It affects ... Bleeding in the mucous membranes. *Bleeding in the brain (very rare). *Bleeding in the joints ... Rare coagulation factor deficiencies. In: Hoffman R, Benz EJ, Silberstein LE, et al, eds. Hematology: Basic Principles and ... Congenital fibrinogen deficiency is a very rare, inherited blood disorder in which the blood does not clot normally. It affects ...
eye and mucous membrane irritation. *in rare cases, allergy. *if oils are inhaled, they may also cause mild lung, throat, or ... Tea tree oil has been associated in rare cases with serious complications. Known side effects of tea tree oil use include:. * ... Sunburn and hells itch: How to get relief In rare cases, people with a sunburn may experience an extreme, deep, painful ... In rare cases, lavender has also been known to cause an allergic response. ...
Dalteparin (Subcutaneous Route) Proper Use - Mayo Clinic
Dalteparin Side Effects in Detail - Drugs.com
Includes common and rare side effects information for consumers and healthcare professionals. ... Rare. *Back pain. *bleeding from mucous membranes. *bluish or black discoloration, flushing, or redness of the skin ... Rare (less than 0.1%): Bullous eruptions, skin necrosis, alopecia[Ref]. Hypersensitivity. Uncommon (0.1% to 1%): ... Rare (less than 0.1%): Immunologically-mediated heparin-induced thrombocytopenia (type II, with or without associated ...
N-ras mutations are common in melanomas from sun-exposed skin of humans but rare in mucosal membranes or unexposed skin
Mucous Membrane * Mutation * Neoplasms, Radiation-Induced / genetics* * Point Mutation * Polymorphism, Single-Stranded ... N-ras mutations are common in melanomas from sun-exposed skin of humans but rare in mucosal membranes or unexposed skin J ... and 28 from unexposed mucosal membranes (vulva/vagina, anus/ rectum, palate). Mutations of both exons of H-, K-, and N-ras ...
Cleocin - FDA prescribing information, side effects and uses
Rare Diseases List and Definitions | Disabled World
... which is sometimes used as a synonym for rare disease ... Information includes a list of rare diseases and the definition ... Mucous Membrane Pemphigoid. *Mulibrey Nanism. *Multifocal Motor Neuropathy. *Multiple Endocrine Neoplasia Type 1 ... There are approximately 7,000 rare diseases (RD). Rare diseases include, some very rare infectious diseases, rare forms of ... The rare disease awareness ribbon is a zebra-striped ribbon.. Incomplete List of Rare Diseases. A B C D E F G H I J K L M N O P ...
4. What could make those products dangerous to swallow? - European Commission
This may be due to the strongly irritating effect which cationic surfactants exhibit on the mucous membrane of the ... In rare cases, vomiting or formation of considerable amounts of foam in the mouth involve an aspiration risk. Aspiration may ... In general, surfactants have an irritating effect on mucous membranes. Foaming is the predominant problem. Manifestations may ... Death due to pine oil ingestion was rare and was reported to be approximately 0.02% (two people). Both cases were the result of ...
Amebic liver abscess: MedlinePlus Medical Encyclopedia
Felbatol (Felbamate): Side Effects, Interactions, Warning, Dosage & Uses
Dermatological: Frequent: Pruritus; Infrequent: urticaria, bullous eruption; Rare: buccal mucous membrane swelling, Stevens- ... Digestive: Frequent: SGOT increased; Infrequent: esophagitis, appetite increased; Rare: GOT elevated.. Hematologic: Infrequent: ... Cardiovascular: Frequent: Palpitation, tachycardia; Rare: supraventricular tachycardia.. Central Nervous System: Frequent: ... Body as a Whole: Frequent: Weight increase, asthenia, malaise, influenza-like symptoms; Rare: anaphylactoid reaction, chest ...
Pyruvate Kinase Deficiency in Cats | petMD
Skin & Beauty: Types, Causes, Symptoms & Treatments | Everyday Health
Dry mucous membrane as in case of Sjogren's syndrome - RightDiagnosis.com
Diagnostic checklist, medical tests, doctor questions, and related signs or symptoms for Dry mucous membrane as in case of ... List of 17 disease causes of Dry mucous membrane as in case of Sjogrens syndrome, patient stories, diagnostic guides. ... 0 causes are "rare" diseases *2 causes are "very rare" diseases *13 causes have no prevalence information. See the analysis of ... Mucous membrane *Mucous membrane symptoms (832 causes) *Sjogrens *Mucous (766 causes) *Membrane *Case *more symptoms...» ...
Cleocin I.V. (Clindamycin): Side Effects, Interactions, Warning, Dosage & Uses
Lischka A[au] - PubMed - NCBI
NCCN Guidelines for Patients® | Hodgkin Lymphoma
Ichthyosis, Erythrokeratodermia Variabilis - NORD (National Organization for Rare Disorders)
Hair, nails, teeth, and mucous membranes are normal.. Causes. Erythrokeratodermia variabilis is genetic and is inherited as an ... Rare Disease Database. 0-9• A• B• C• D• E• F• G• H• I• J• K• L• M• N• O• P• Q• R• S• T• U• V• W• X• Y• Z ... The information in NORDs Rare Disease Database is for educational purposes only and is not intended to replace the advice of a ... The content of the website and databases of the National Organization for Rare Disorders (NORD) is copyrighted and may not be ...
Syphilis: Gummata | HealthLink BC
Skin rash: 68 pictures, causes, and treatments
Cicatricial pemphigoid - mostly affects mucous membranes.. *Pemphigoid gestationis - develops during pregnancy and mostly ... Reyes syndrome is rare and most commonly occurs in children. It can cause serious damage to the bodys organs, particularly ... Kawasakis disease is a rare syndrome that affects children. It is characterized by an inflammation of the walls of the ... Toxic shock syndrome is a rare condition sparked by a bacterial infection. It develops quickly and can be life-threatening. All ...
Laboratory Primate Newsletter, Volume 35, Number 3
The mucous membrane is swollen, presenting ulceration and sloughing. Diagnosis is based on recognition of the oocysts in the ... They have been reported in wild-caught callitrichids (Burrows, 1972). The infection is extremely rare. Symptoms range from mild ... The number of parasites in a host cell varies from a few to 100 (Kudo, 1977). Oral and nasal mucous membrane ulcerations are ... Chronic colitis, congestion, petechial hemorrhages, and sores occur (Burrows, 1972). The amoebas invade the mucous membrane, ...
Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis - NORD (National Organization for Rare Disorders)
Skin and mucous membrane involvement initially can be mild or it can rapidly progress. Some individuals may have severe skin ... Rare Disease Database. 0-9• A• B• C• D• E• F• G• H• I• J• K• L• M• N• O• P• Q• R• S• T• U• V• W• X• Y• Z ... Mucous membrane involvement can precede or follow skin symptoms and often begins with soreness, then little blisters or "bumps ... Involvement of the mucous membranes lining the respiratory tract can lead to lung damage, bronchitis, chronic obstructive ...
Stevens-Johnson Syndrome: Symptoms, Causes & Treatment | Disabled World
... a disorder of the skin and mucous membranes - usually a reaction to medication or an infection ... Blisters on the skin or mucous membranes. Causes of Stevens-Johnson Syndrome. Stevens-Johnson syndrome is rare and people have ... Ulcers and other lesions begin to appear in the mucous membranes, almost always in the mouth and lips, but also in the genital ... Stevens-Johnson syndrome is a serious disorder of the skin and mucous membranes. It is usually a reaction to a medication or an ...
Unilateral Oral Mucous Membrane Pemphigoid: Refractory Atypical Presentation Successfully Treated with Intravenous...
The authors report a rare unilateral presentation of oral mucous membrane pemphigoid on the right buccal and hard palate mucosa ... K. A. Rashid, H. M. Gürcan, and A. R. Ahmed, "Antigen specificity in subsets of mucous membrane pemphigoid," Journal of ... L. S. Chan, "Ocular and oral mucous membrane pemphigoid (cicatricial pemphigoid)," Clinics in Dermatology, vol. 30, no. 1, pp. ... A. S. Kourosh and K. B. Yancey, "Pathogenesis of mucous membrane pemphigoid," Dermatologic Clinics, vol. 29, no. 3, pp. 479-484 ...
Randomized Clinical Trial Comparing the Safety and Efficacy of Rituximab Versus Oral Cyclophosphamide in Severe Forms of Mucous...
Genetic and Rare Diseases Information Center resources: Bullous Pemphigoid Mucous Membrane Pemphigoid ... mucous membrane and skin erosions and blisters), and the MMP DAI damage score, which assesses disease damage (mucous membrane ... mucous membrane and skin erosions and blisters), and the MMP DAI damage score, which assesses disease damage (mucous membrane ... mucous membrane and skin erosions and blisters), and the MMP DAI damage score, which assesses disease damage (mucous membrane ...
Mucous Membrane Pemphigoid | British Skin Foundation
Pyoderma gangrenosum is a rare treatable cause of skin ulceration. It is not a type of gangrene. Pyoderma gangrenosum is not ... Mucous Membrane Pemphigoid. What is mucous membrane pemphigoid (MMP)?. MMP is the most up-to-date term for this condition. ... Other moist surfaces of the body (known as mucous membranes) can also be affected, and these include the surface layers of the ... or other mucous membranes) causing blisters, which usually break down to leave ulcers. MMP is not contagious, or due to food ...
Notes from the Field: Assessing Rabies Risk After a Mass Bat Exposure at a Research Facility in a National Park - Wyoming, 2017...
DailyMed - CLINDAMYCIN- clindamycin phosphate injection
PemphigoidSkinDisorderAntibodiesConjunctivaDiagnosisDiseaseBlistersInvolvementEsophagusGenitalsMucosal membranesNailsMucus membranesIrritationSalivaMalignantSymptomsAffects the skinEyesMoistStevens-JohnsonTissuesDiseasesPatientsNasalEnters the bodyDisordersBodyBacteriaCell membraneAcuteHumansRecurrentDeficiencyAvoid
- Mucous membrane pemphigoid is also called cicatricial pemphigoid or oral pemphigoid. (dermnetnz.org)
- Brunsting Perry cicatricial pemphigoid is a rare variant in which localised crops of recurrent blisters arise within urticarial plaques , usually on the head and neck. (dermnetnz.org)
- Mucous membrane pemphigoid is predominantly a disease of the elderly with a peak incidence at around 70 years. (dermnetnz.org)
- What are the signs and symptoms of mucous membrane pemphigoid? (dermnetnz.org)
- Mucous membrane pemphigoid is an autoimmune blistering disease , which basically means that an individual's immune systems starts reacting against his or her own tissue. (dermnetnz.org)
- How is mucous membrane pemphigoid diagnosed? (dermnetnz.org)
- Mucous membrane pemphigoid is suspected from the clinical appearance of blisters and scarring. (dermnetnz.org)
- The severity of the mucous membrane pemphigoid can be assessed using the mucous membrane pemphigoid disease area index (MMPDAI). (dermnetnz.org)
- Mucous membrane pemphigoid is a particularly difficult disease to treat as it can affect so many different parts of the body. (dermnetnz.org)
- Mucous Membrane Pemphigoid Treatment Market Report Explor. (pharmiweb.com)
- VALLEY COTTAGE, N.Y. - Mucous membrane pemphigoid is a group of rare and chronic autoimmune diseases which are characterized by blistering on the various mucous layers of the body. (pharmiweb.com)
- Mucous membranes of mouth, nose, throat, and eye are often affected by the mucous membrane pemphigoid. (pharmiweb.com)
- The manufacturers in mucous membrane pemphigoid treatment market are focusing on the developing new and effective formulations. (pharmiweb.com)
- Being a rare disease, mucous membrane pemphigoid treatment market offers limited patients pool for the treatment and hence manufacturers are developing new formulation by keeping an eye on the overall potential economic return as well as development expenditure. (pharmiweb.com)
- The incidence of mucous membrane pemphigoid varies widely, for example, the incidence of mucous membrane pemphigoid U.K. is 1 in million population whereas in Germany and France the incidence is 2 in million population. (pharmiweb.com)
- The average age of onset of mucous membrane pemphigoid is 60 years and hence the ageing population of the world expected to result in increased incidence of the disease driving the growth of the mucous membrane pemphigoid treatment market . (pharmiweb.com)
- The increasing availability of treatment option further expected to fuel the growth of the mucous membrane pemphigoid treatment market. (pharmiweb.com)
- The increasing rate of diagnosis due to improving awareness about the disease further expected to enhance treatment-seeking rate, in turn, driving the growth of mucous membrane pemphigoid treatment market. (pharmiweb.com)
- Manufacturers in the mucous membrane pemphigoid treatment market are focusing on product approvals and launches in the developed as well as developing world which expected to increase their geographical product footprint fueling the growth of the mucous membrane pemphigoid treatment market. (pharmiweb.com)
- Due to rare disease status, the disease, mucous membrane pemphigoid treatment options are given special status and exclusivity to encourage manufacturers to develop advanced mucous membrane pemphigoid treatment, in turn, driving the growth of the market. (pharmiweb.com)
- Whereas, limited awareness and low diagnosis rate in developing part of the world may hamper the potential growth of the mucous membrane pemphigoid treatment market. (pharmiweb.com)
- The mucous membrane pemphigoid treatment mainly is driven by the increasing treatment-seeking rate and increased awareness. (pharmiweb.com)
- The mucous membrane pemphigoid treatment market by drug class is expected to be dominated by monoclonal antibodies due to their high efficacy in mucous membrane pemphigoid treatment. (pharmiweb.com)
- The global mucous membrane pemphigoid treatment market by route of administration is expected to be dominated by injectables due to high therapeutic bioavailability in the blood and effective delivery of drugs. (pharmiweb.com)
- The global mucous membrane pemphigoid treatment market by distribution channel is expected to be dominated by the retail pharmacies due to high patient footfall. (pharmiweb.com)
- The global mucous membrane pemphigoid treatment market is expected to be dominated by North America due to the high prevalence of the disease as well as high treatment-seeking rate. (pharmiweb.com)
- Europe is expected to be the second most lucrative mucous membrane pemphigoid treatment market due to increasing product adoption for the treatment. (pharmiweb.com)
- These include the rare autoimmune blistering diseases mucous membrane pemphigoid (MMP), pemphigus vulgaris (PV), linear IgA disease (LAD), epidermolysis bullosa acquisita (EBA) and paraneoplastic pemphigus (PNP). (kcl.ac.uk)
- Here we discuss mucous membrane pemphigoid (MMP) and its important differential diagnoses. (kcl.ac.uk)
- Mucous membrane pemphigoid (MMP) is a rare, chronic and vesiculobullous disorder that classified as autoimmune disease.MMP can affect various mucous membranes but predominantly occurs in the oral cavity. (ommegaonline.org)
- Mucous membrane pemphigoid (MMP) is a rare, chronic and vesiculobullous disorder that classified as autoimmune disease. (ommegaonline.org)
- In this particular instance autoantibodies react with proteins found in mucous membranes and skin tissue resulting in blistering lesions. (dermnetnz.org)
- Stevens-Johnson (SJ) syndrome is a rare but serious and potentially life-threatening disorder of the skin and mucous membranes, usually developing as a reaction to a medication or an infection. (wikihow.com)
- Stevens - Johnson syndrome is a rare but serious disorder of the skin and mucous membranes characterized by inflammation of the mucous membrane leading to the red or purplish rash. (askdrshah.com)
- Blisters may form on various external and internal mucous membranes of the body including the lining inside of the mouth (stomatitis), nose and genitals. (rarediseases.org)
- They may experience a red or purplish rash that spreads within hours to days, blisters on their skin and the mucous membranes of their nose, mouth, genitals and eyes, followed by shedding of their skin. (disabled-world.com)
- It is considered to be an autoimmune disease involving antibodies (natural substances important in defending your body against infections) that react with the surface layer of your mouth (or other mucous membranes) causing blisters, which usually break down to leave ulcers. (britishskinfoundation.org.uk)
- Epidermolysis bullosa is a genetic condition that results in fragility of the skin and mucous membranes, causing blisters after minor trauma or spontaneously. (outlookindia.com)
- A genetic condition that results in fragility of the skin and mucous membranes, causing blisters after minor trauma or spontaneously, it is caused by specific mutations in one of at least 18 genes res-ponsible for production of proteins vital to the skin's structural integrity. (outlookindia.com)
- Any type of fiction on Trippâ€™s skin or mucous membranes causes blisters. (bloggernews.net)
- It causes blisters on the skin and mucous membranes throughout the body. (ahealthyme.com)
- Pemphigus is a rare group of autoimmune diseases that causes blisters on the skin and mucous membranes throughout the body. (ahealthyme.com)
- In addition to the painful blisters, Rafi needs frequent throat surgeries, because her condition also affects mucous membranes. (opb.org)
- A genetic modification in the mucous membrane of the esophagus, the Barrett esophagus, can lead to esophageal cancer. (medicalxpress.com)
- In addition to the cutaneous and oral symptoms, severe forms are associated with erosions and scarring of mucous membranes of the eye, esophagus, genitals, and anus. (prnewswire.com)
- Less frequently the mucous membranes of the nose, esophagus, genitalia and rectum are involved. (abcam.com)
- CMCC is a heterogeneous group of disorders characterized by chronic candidal infections of the nails, skin, and mucous membranes. (medscape.com)
- Pachyonychia congenita is a disease affecting the nails, skin, hair, teeth and on occasion the mucous membranes. (socialstyrelsen.se)
- Symptoms affecting skin, hair, nails and mucous membranes differ depending on which of the keratin genes have mutated, causing various types of the disease. (socialstyrelsen.se)
- A pus-producing (purulent) cough that also brings up mucous, phlegm and saliva (sputum) may also occur. (rarediseases.org)
- however, scratches or mucous membrane contact with saliva also present transmission risks ( 1 - 3 ). (cdc.gov)
- Rabies viruses can infect most mammals and are usually spread when saliva from a rabid animal enters the body via a mucous membrane, a puncture wound, or open cut. (alleycat.org)
- Infected saliva must enter an open wound or mucous membrane to transmit the virus. (alleycat.org)
- The reaction may start with a persistent fever and nonspecific, flu-like symptoms followed by appearance of erythematous macules (red spots) that may cover a large part of the body, and painful blistering of the skin and mucous membranes. (rarediseases.org)
- The telephone survey of 98 workers indicated that the workers at Furnace Number 1 producing rare earth silicide were more likely to report one or more symptoms of various irritative, respiratory, gastrointestinal and constitutional disorders than other workers. (cdc.gov)
- The follow-up medical questionnaire showed no statistically significant difference in reported symptoms between workers exposed to rare earth and those not exposed. (cdc.gov)
- The authors recommend that management expand its rare earth training to all personnel, that employees report any symptoms experienced while working with rare earths, and that ventilation be improved for rare earth silicide storage and for ladlemen and helpers at their specific work sites. (cdc.gov)
- Listed below are some combinations of symptoms associated with Dry mucous membrane as in case of Sjogren's syndrome, as listed in our database. (rightdiagnosis.com)
- Systemic symptoms are rare, but fever and malaise have been reported. (renalandurologynews.com)
- Symptoms include extreme skin and mucosal fragility and can also include erosions and scarring of other mucous membranes throughout the body. (prnewswire.com)
- Early symptoms include malaise, sore throat, anorexia, and low-grade fever (less than 101°F). Within 2 to 3 days, a bluish-white membrane forms and extends, varying in size from covering a small patch on the tonsils to covering most of the soft palate. (cdc.gov)
Affects the skin1
- Almost all infections make us sick by getting past our first line of defense - the sticky mucous surfaces that line our mouths, our eyes, our lungs and our guts. (medicalxpress.com)
- Capsaicin cream can be very irritating to mucous membranes, the eyes, and broken skin. (mskcc.org)
- Avoid contact with eyes or mucous membranes. (revivalanimal.com)
- You should not let cayenne touch your mucous membranes, especially your eyes. (lifebridgehealth.org)
- It turns your skin, mucous membranes, sclera (the white of your eyes) into a single yellow color. (bartleby.com)
- The European Union (EU) defines rare diseases as conditions that affect less than 1 in 2,000 people, but many are much rarer. (disabled-world.com)
- There are approximately 7,000 rare diseases (RD). Rare diseases include, some very rare infectious diseases, rare forms of autoimmune disorders, and rare cancers. (disabled-world.com)
- There is no single, widely accepted definition for rare diseases. (disabled-world.com)
- Canada: According to the Canadian Organization for Rare Diseases (CORD), rare diseases affect one in 12 Canadians (two-thirds of whom are children). (disabled-world.com)
- The awareness day was originally started by the European Organization for Rare Diseases and is now recognized globally. (disabled-world.com)
- This information refers to the general prevalence and incidence of these diseases, not to how likely they are to be the actual cause of Dry mucous membrane as in case of Sjogren's syndrome. (rightdiagnosis.com)
- Pemphigus is a rare group of autoimmune diseases. (ahealthyme.com)
- This is part of Rare diseases . (socialstyrelsen.se)
Enters the body1
- Triggers may induce an autoimmune reaction by mimicking molecular sequences in the epidermal basement membrane (molecular mimicry, as with drugs and possibly infections), by exposing or altering normally tolerated host antigens (as with physical triggers and certain disorders), or by other mechanisms. (msdmanuals.com)
- it possesses an undulating membrane bordered by a flagellum that is free at one end of the body (Flynn, 1973). (brown.edu)
- You can get HIV during sexual contact, sharing needles, through mucous membranes, and cuts on your body if they come in contact with fluids from someone with HIV, i.E., blood, and semen, vaginal fluid, breast milk. (debate.org)
- Mucous membranes help protect against germs but, unlike the skin, which is an excellent barrier against germs and many other things that should not be inside our bodies, mucous membranes allow some things to cross into and out of the body. (debate.org)
- Below the surface of mucous membranes there are many immune cells, which help to protect the body against possible infections. (debate.org)
- In mixtures, the combined action of the different types of surfactants may exacerbate the toxic effects of each other and also other ingredients present in low concentrations by increasing cell membrane permeability. (europa.eu)
- A variety of plants contain compounds that damage red blood cell (RBCs) metabolism and cell membrane integrity causing them to be removed from the circulation by the spleen. (ivis.org)
- 2.4 First-aid measures and management principles Considerable toxicity is unlikely after an acute exposure, with the exception of rare but dramatic arrhythmias including cardiac arrest after rapid i.v. injection of drugs containing large amounts of propylene glycol solvent. (inchem.org)
- It is an acute inflammatory, self-limiting dermatosis involving skin and mucous membranes. (google.nl)