The use of IONIZING RADIATION to treat malignant NEOPLASMS and some benign conditions.
The total amount of radiation absorbed by tissues as a result of radiotherapy.
Radiotherapy where there is improved dose homogeneity within the tumor and reduced dosage to uninvolved structures. The precise shaping of dose distribution is achieved via the use of computer-controlled multileaf collimators.
Radiotherapy given to augment some other form of treatment such as surgery or chemotherapy. Adjuvant radiotherapy is commonly used in the therapy of cancer and can be administered before or after the primary treatment.
CONFORMAL RADIOTHERAPY that combines several intensity-modulated beams to provide improved dose homogeneity and highly conformal dose distributions.
Computer-assisted mathematical calculations of beam angles, intensities of radiation, and duration of irradiation in radiotherapy.
Radiotherapy using high-energy (megavolt or higher) ionizing radiation. Types of radiation include gamma rays, produced by a radioisotope within a teletherapy unit; x-rays, electrons, protons, alpha particles (helium ions) and heavy charged ions, produced by particle acceleration; and neutrons and pi-mesons (pions), produced as secondary particles following bombardment of a target with a primary particle.
The treatment of a disease or condition by several different means simultaneously or sequentially. Chemoimmunotherapy, RADIOIMMUNOTHERAPY, chemoradiotherapy, cryochemotherapy, and SALVAGE THERAPY are seen most frequently, but their combinations with each other and surgery are also used.
Administration of the total dose of radiation (RADIATION DOSAGE) in parts, at timed intervals.
Harmful effects of non-experimental exposure to ionizing or non-ionizing radiation in VERTEBRATES.
Computer systems or programs used in accurate computations for providing radiation dosage treatment to patients.
The use of pre-treatment imaging modalities to position the patient, delineate the target, and align the beam of radiation to achieve optimal accuracy and reduce radiation damage to surrounding non-target tissues.
A subspecialty of medical oncology and radiology concerned with the radiotherapy of cancer.
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
A radiological stereotactic technique developed for cutting or destroying tissue by high doses of radiation in place of surgical incisions. It was originally developed for neurosurgery on structures in the brain and its use gradually spread to radiation surgery on extracranial structures as well. The usual rigid needles or probes of stereotactic surgery are replaced with beams of ionizing radiation directed toward a target so as to achieve local tissue destruction.
Soft tissue tumors or cancer arising from the mucosal surfaces of the LIP; oral cavity; PHARYNX; LARYNX; and cervical esophagus. Other sites included are the NOSE and PARANASAL SINUSES; SALIVARY GLANDS; THYROID GLAND and PARATHYROID GLANDS; and MELANOMA and non-melanoma skin cancers of the head and neck. (from Holland et al., Cancer Medicine, 4th ed, p1651)
The relationship between the dose of administered radiation and the response of the organism or tissue to the radiation.
A collective term for interstitial, intracavity, and surface radiotherapy. It uses small sealed or partly-sealed sources that may be placed on or near the body surface or within a natural body cavity or implanted directly into the tissues.
The local recurrence of a neoplasm following treatment. It arises from microscopic cells of the original neoplasm that have escaped therapeutic intervention and later become clinically visible at the original site.
Methods which attempt to express in replicable terms the extent of the neoplasm in the patient.
Treatment that combines chemotherapy with radiotherapy.
The use of two or more chemicals simultaneously or sequentially in the drug therapy of neoplasms. The drugs need not be in the same dosage form.
Tumors or cancer of the NASOPHARYNX.
Period after successful treatment in which there is no appearance of the symptoms or effects of the disease.
Neoplasms of the intracranial components of the central nervous system, including the cerebral hemispheres, basal ganglia, hypothalamus, thalamus, brain stem, and cerebellum. Brain neoplasms are subdivided into primary (originating from brain tissue) and secondary (i.e., metastatic) forms. Primary neoplasms are subdivided into benign and malignant forms. In general, brain tumors may also be classified by age of onset, histologic type, or presenting location in the brain.
A carcinoma derived from stratified SQUAMOUS EPITHELIAL CELLS. It may also occur in sites where glandular or columnar epithelium is normally present. (From Stedman, 25th ed)
The ability of some cells or tissues to survive lethal doses of IONIZING RADIATION. Tolerance depends on the species, cell type, and physical and chemical variables, including RADIATION-PROTECTIVE AGENTS and RADIATION-SENSITIZING AGENTS.
Organs which might be damaged during exposure to a toxin or to some form of therapy. It most frequently refers to healthy organs located in the radiation field during radiation therapy.
The proportion of survivors in a group, e.g., of patients, studied and followed over a period, or the proportion of persons in a specified group alive at the beginning of a time interval who survive to the end of the interval. It is often studied using life table methods.
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
Drugs used to potentiate the effectiveness of radiation therapy in destroying unwanted cells.
A class of statistical procedures for estimating the survival function (function of time, starting with a population 100% well at a given time and providing the percentage of the population still well at later times). The survival analysis is then used for making inferences about the effects of treatments, prognostic factors, exposures, and other covariates on the function.
Tumors or cancer of the LUNG.
Tumors or cancer of the RECTUM.
Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.
Drug therapy given to augment or stimulate some other form of treatment such as surgery or radiation therapy. Adjuvant chemotherapy is commonly used in the therapy of cancer and can be administered before or after the primary treatment.
Devices which accelerate electrically charged atomic or subatomic particles, such as electrons, protons or ions, to high velocities so they have high kinetic energy.
An inorganic and water-soluble platinum complex. After undergoing hydrolysis, it reacts with DNA to produce both intra and interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity of cisplatin correlates with cellular arrest in the G2 phase of the cell cycle.
The exposure of the head to roentgen rays or other forms of radioactivity for therapeutic or preventive purposes.
A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.
The measurement of radiation by photography, as in x-ray film and film badge, by Geiger-Mueller tube, and by SCINTILLATION COUNTING.
Tumors or cancer of the PROSTATE.
Inflammation of the lung due to harmful effects of ionizing or non-ionizing radiation.
The amount of radiation energy that is deposited in a unit mass of material, such as tissues of plants or animal. In RADIOTHERAPY, radiation dosage is expressed in gray units (Gy). In RADIOLOGIC HEALTH, the dosage is expressed by the product of absorbed dose (Gy) and quality factor (a function of linear energy transfer), and is called radiation dose equivalent in sievert units (Sv).
Tumors or cancer of the pelvic region.
Cancers or tumors of the LARYNX or any of its parts: the GLOTTIS; EPIGLOTTIS; LARYNGEAL CARTILAGES; LARYNGEAL MUSCLES; and VOCAL CORDS.
Removal of only enough breast tissue to ensure that the margins of the resected surgical specimen are free of tumor.
Tumors or cancer of the human BREAST.
A malignant disease characterized by progressive enlargement of the lymph nodes, spleen, and general lymphoid tissue. In the classical variant, giant usually multinucleate Hodgkin's and REED-STERNBERG CELLS are present; in the nodular lymphocyte predominant variant, lymphocytic and histiocytic cells are seen.
A cutaneous inflammatory reaction occurring as a result of exposure to ionizing radiation.
The use of a heavy ion particle beam for radiotherapy, such as the HEAVY IONS of CARBON.
Tumors, cancer or other neoplasms produced by exposure to ionizing or non-ionizing radiation.
An antitumor alkaloid isolated from VINCA ROSEA. (Merck, 11th ed.)
Abnormal growths of tissue that follow a previous neoplasm but are not metastases of the latter. The second neoplasm may have the same or different histological type and can occur in the same or different organs as the previous neoplasm but in all cases arises from an independent oncogenic event. The development of the second neoplasm may or may not be related to the treatment for the previous neoplasm since genetic risk or predisposing factors may actually be the cause.
Tomography using x-ray transmission and a computer algorithm to reconstruct the image.
An antineoplastic agent. It has significant activity against melanomas. (from Martindale, The Extra Pharmacopoeia, 31st ed, p564)
Techniques, procedures, and therapies carried out on diseased organs in such a way to avoid complete removal of the organ and preserve the remaining organ function.
Decreased salivary flow.
An antineoplastic agent used primarily in combination with mechlorethamine, vincristine, and prednisone (the MOPP protocol) in the treatment of Hodgkin's disease.
A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
Preliminary cancer therapy (chemotherapy, radiation therapy, hormone/endocrine therapy, immunotherapy, hyperthermia, etc.) that precedes a necessary second modality of treatment.
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.
A type of high-energy radiotherapy using a beam of gamma-radiation produced by a radioisotope source encapsulated within a teletherapy unit.
Substances that inhibit or prevent the proliferation of NEOPLASMS.
Elements of limited time intervals, contributing to particular results or situations.
Care alleviating symptoms without curing the underlying disease. (Stedman, 25th ed)
A malignant epithelial tumor with a glandular organization.
Unstable isotopes of cobalt that decay or disintegrate emitting radiation. Co atoms with atomic weights of 54-64, except 59, are radioactive cobalt isotopes.
A heterogeneous aggregate of at least three distinct histological types of lung cancer, including SQUAMOUS CELL CARCINOMA; ADENOCARCINOMA; and LARGE CELL CARCINOMA. They are dealt with collectively because of their shared treatment strategy.
External or interstitial irradiation to treat lymphomas (e.g., Hodgkin's and non-Hodgkin's lymphomas) and lymph node metastases and also some autoimmune diseases, such as rheumatoid arthritis.
A biologic alkylating agent that exerts its cytotoxic effects by forming DNA ADDUCTS and DNA interstrand crosslinks, thereby inhibiting rapidly proliferating cells. The hydrochloride is an antineoplastic agent used to treat HODGKIN DISEASE and LYMPHOMA.
Tumors or cancer of the UTERINE CERVIX.
A malignant neoplasm made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases. It is a histological type of neoplasm but is often wrongly used as a synonym for "cancer." (From Dorland, 27th ed)
A malignant form of astrocytoma histologically characterized by pleomorphism of cells, nuclear atypia, microhemorrhage, and necrosis. They may arise in any region of the central nervous system, with a predilection for the cerebral hemispheres, basal ganglia, and commissural pathways. Clinical presentation most frequently occurs in the fifth or sixth decade of life with focal neurologic signs or seizures.
Drugs used to protect against ionizing radiation. They are usually of interest for use in radiation therapy but have been considered for other, e.g. military, purposes.
A therapeutic approach, involving chemotherapy, radiation therapy, or surgery, after initial regimens have failed to lead to improvement in a patient's condition. Salvage therapy is most often used for neoplastic diseases.
A complex of related glycopeptide antibiotics from Streptomyces verticillus consisting of bleomycin A2 and B2. It inhibits DNA metabolism and is used as an antineoplastic, especially for solid tumors.
A nonparametric method of compiling LIFE TABLES or survival tables. It combines calculated probabilities of survival and estimates to allow for observations occurring beyond a measurement threshold, which are assumed to occur randomly. Time intervals are defined as ending each time an event occurs and are therefore unequal. (From Last, A Dictionary of Epidemiology, 1995)
Surgical procedure to remove one or both breasts.
Unstable isotopes of iridium that decay or disintegrate emitting radiation. Ir atoms with atomic weights 182-190, 192, and 194-198 are radioactive iridium isotopes.
Necrosis of bone following radiation injury.
A class of drugs that differs from other alkylating agents used clinically in that they are monofunctional and thus unable to cross-link cellular macromolecules. Among their common properties are a requirement for metabolic activation to intermediates with antitumor efficacy and the presence in their chemical structures of N-methyl groups, that after metabolism, can covalently modify cellular DNA. The precise mechanisms by which each of these drugs acts to kill tumor cells are not completely understood. (From AMA, Drug Evaluations Annual, 1994, p2026)
The space or compartment surrounded by the pelvic girdle (bony pelvis). It is subdivided into the greater pelvis and LESSER PELVIS. The pelvic girdle is formed by the PELVIC BONES and SACRUM.
Tumors or cancer of the ESOPHAGUS.
Benign and malignant central nervous system neoplasms derived from glial cells (i.e., astrocytes, oligodendrocytes, and ependymocytes). Astrocytes may give rise to astrocytomas (ASTROCYTOMA) or glioblastoma multiforme (see GLIOBLASTOMA). Oligodendrocytes give rise to oligodendrogliomas (OLIGODENDROGLIOMA) and ependymocytes may undergo transformation to become EPENDYMOMA; CHOROID PLEXUS NEOPLASMS; or colloid cysts of the third ventricle. (From Escourolle et al., Manual of Basic Neuropathology, 2nd ed, p21)
Transfer of a neoplasm from its primary site to lymph nodes or to distant parts of the body by way of the lymphatic system.
The total amount (cell number, weight, size or volume) of tumor cells or tissue in the body.
Antineoplastic antibiotic obtained from Streptomyces peucetius. It is a hydroxy derivative of DAUNORUBICIN.
Moving a patient into a specific position or POSTURE to facilitate examination, surgery, or for therapeutic purposes.
Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.
Mistakes committed in the preparations for radiotherapy, including errors in positioning of patients, alignment radiation beams, or calculation of radiation doses.
Materials used as reference points for imaging studies.
Antitumor alkaloid isolated from Vinca rosea. (Merck, 11th ed.)
A connective tissue neoplasm formed by proliferation of mesodermal cells; it is usually highly malignant.
Total or partial excision of the larynx.
Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the LIVER to form the active aldophosphamide. It has been used in the treatment of LYMPHOMA and LEUKEMIA. Its side effect, ALOPECIA, has been used for defleecing sheep. Cyclophosphamide may also cause sterility, birth defects, mutations, and cancer.
Compounds which inhibit or antagonize the biosynthesis or actions of androgens.
Studies to determine the advantages or disadvantages, practicability, or capability of accomplishing a projected plan, study, or project.
Tumors or cancer of the OROPHARYNX.
Positively-charged atomic nuclei that have been stripped of their electrons. These particles have one or more units of electric charge and a mass exceeding that of the Helium-4 nucleus (alpha particle).
Primary and metastatic (secondary) tumors of the brain located above the tentorium cerebelli, a fold of dura mater separating the CEREBELLUM and BRAIN STEM from the cerebral hemispheres and DIENCEPHALON (i.e., THALAMUS and HYPOTHALAMUS and related structures). In adults, primary neoplasms tend to arise in the supratentorial compartment, whereas in children they occur more frequently in the infratentorial space. Clinical manifestations vary with the location of the lesion, but SEIZURES; APHASIA; HEMIANOPSIA; hemiparesis; and sensory deficits are relatively common features. Metastatic supratentorial neoplasms are frequently multiple at the time of presentation.
An alkylating agent of value against both hematologic malignancies and solid tumors.
The use of an external beam of PROTONS as radiotherapy.
Antineoplastic agent especially effective against malignant brain tumors. The resistance which brain tumor cells acquire to the initial effectiveness of this drug can be partially overcome by the simultaneous use of membrane-modifying agents such as reserpine, calcium antagonists such as nicardipine or verapamil, or the calmodulin inhibitor, trifluoperazine. The drug has also been used in combination with other antineoplastic agents or with radiotherapy for the treatment of various neoplasms.
Tumors or cancer of the HYPOPHARYNX.
Time schedule for administration of a drug in order to achieve optimum effectiveness and convenience.
An imaging technique using compounds labelled with short-lived positron-emitting radionuclides (such as carbon-11, nitrogen-13, oxygen-15 and fluorine-18) to measure cell metabolism. It has been useful in study of soft tissues such as CANCER; CARDIOVASCULAR SYSTEM; and brain. SINGLE-PHOTON EMISSION-COMPUTED TOMOGRAPHY is closely related to positron emission tomography, but uses isotopes with longer half-lives and resolution is lower.
A phosphorothioate proposed as a radiation-protective agent. It causes splenic vasodilation and may block autonomic ganglia.
Therapeutic act or process that initiates a response to a complete or partial remission level.
Tumors or cancer located in bone tissue or specific BONES.
A synthetic anti-inflammatory glucocorticoid derived from CORTISONE. It is biologically inert and converted to PREDNISOLONE in the liver.
Compounds that are used in medicine as sources of radiation for radiotherapy and for diagnostic purposes. They have numerous uses in research and industry. (Martindale, The Extra Pharmacopoeia, 30th ed, p1161)
The transfer of a neoplasm from one organ or part of the body to another remote from the primary site.
An INFLAMMATION of the MUCOSA with burning or tingling sensation. It is characterized by atrophy of the squamous EPITHELIUM, vascular damage, inflammatory infiltration, and ulceration. It usually occurs at the mucous lining of the MOUTH, the GASTROINTESTINAL TRACT or the airway due to chemical irritations, CHEMOTHERAPY, or radiation therapy (RADIOTHERAPY).
Benign and malignant neoplastic processes that arise from or secondarily involve the brain, spinal cord, or meninges.
Neoplasms of the base of the skull specifically, differentiated from neoplasms of unspecified sites or bones of the skull (SKULL NEOPLASMS).
Tumors or cancer of the NOSE.
ELECTROMAGNETIC RADIATION or particle radiation (high energy ELEMENTARY PARTICLES) capable of directly or indirectly producing IONS in its passage through matter. The wavelengths of ionizing electromagnetic radiation are equal to or smaller than those of short (far) ultraviolet radiation and include gamma and X-rays.
Combined chemotherapy and radiotherapy given to augment some other form of treatment such as surgery. It is commonly used in the therapy of cancer.
A semisynthetic derivative of PODOPHYLLOTOXIN that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent entry into the mitotic phase of cell division, and lead to cell death. Etoposide acts primarily in the G2 and S phases of the cell cycle.
A malignant olfactory neuroblastoma arising from the olfactory epithelium of the superior nasal cavity and cribriform plate. It is uncommon (3% of nasal tumors) and rarely is associated with the production of excess hormones (e.g., SIADH, Cushing Syndrome). It has a high propensity for multiple local recurrences and bony metastases. (From Holland et al., Cancer Medicine, 3rd ed, p1245; J Laryngol Otol 1998 Jul;112(7):628-33)
Vinblastine derivative with antineoplastic activity against CANCER. Major side effects are myelosuppression and neurotoxicity. Vindesine is used extensively in chemotherapy protocols (ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS).
A generic concept reflecting concern with the modification and enhancement of life attributes, e.g., physical, political, moral and social environment; the overall condition of a human life.
Benign and malignant neoplastic processes that arise from or secondarily involve the meningeal coverings of the brain and spinal cord.
The period of care beginning when the patient is removed from surgery and aimed at meeting the patient's psychological and physical needs directly after surgery. (From Dictionary of Health Services Management, 2d ed)
An organoplatinum compound that possesses antineoplastic activity.
INFLAMMATION of the soft tissues of the MOUTH, such as MUCOSA; PALATE; GINGIVA; and LIP.
Neoplasms of the brain and spinal cord derived from glial cells which vary from histologically benign forms to highly anaplastic and malignant tumors. Fibrillary astrocytomas are the most common type and may be classified in order of increasing malignancy (grades I through IV). In the first two decades of life, astrocytomas tend to originate in the cerebellar hemispheres; in adults, they most frequently arise in the cerebrum and frequently undergo malignant transformation. (From Devita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2013-7; Holland et al., Cancer Medicine, 3d ed, p1082)
Care given during the period prior to undergoing surgery when psychological and physical preparations are made according to the special needs of the individual patient. This period spans the time between admission to the hospital to the time the surgery begins. (From Dictionary of Health Services Management, 2d ed)
A measure of the quality of health care by assessment of unsuccessful results of management and procedures used in combating disease, in individual cases or series.
A glycoprotein that is a kallikrein-like serine proteinase and an esterase, produced by epithelial cells of both normal and malignant prostate tissue. It is an important marker for the diagnosis of prostate cancer.
Statistical models used in survival analysis that assert that the effect of the study factors on the hazard rate in the study population is multiplicative and does not change over time.
The science concerned with problems of radiation protection relevant to reducing or preventing radiation exposure, and the effects of ionizing radiation on humans and their environment.
The application of probability and statistical methods to calculate the risk of occurrence of any event, such as onset of illness, recurrent disease, hospitalization, disability, or death. It may include calculation of the anticipated money costs of such events and of the premiums necessary to provide for payment of such costs.
Three-dimensional computed tomographic imaging with the added dimension of time, to follow motion during imaging.
Non-invasive method of demonstrating internal anatomy based on the principle that atomic nuclei in a strong magnetic field absorb pulses of radiofrequency energy and emit them as radiowaves which can be reconstructed into computerized images. The concept includes proton spin tomographic techniques.
Complete or partial surgical removal of the prostate. Three primary approaches are commonly employed: suprapubic - removal through an incision above the pubis and through the urinary bladder; retropubic - as for suprapubic but without entering the urinary bladder; and transurethral (TRANSURETHRAL RESECTION OF PROSTATE).
Study of the scientific principles, mechanisms, and effects of the interaction of ionizing radiation with living matter. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
The distal segment of the LARGE INTESTINE, between the SIGMOID COLON and the ANAL CANAL.
Total mastectomy with axillary node dissection, but with preservation of the pectoral muscles.
Tumors or cancer of the TESTIS. Germ cell tumors (GERMINOMA) of the testis constitute 95% of all testicular neoplasms.
A relatively common neoplasm of the CENTRAL NERVOUS SYSTEM that arises from arachnoidal cells. The majority are well differentiated vascular tumors which grow slowly and have a low potential to be invasive, although malignant subtypes occur. Meningiomas have a predilection to arise from the parasagittal region, cerebral convexity, sphenoidal ridge, olfactory groove, and SPINAL CANAL. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2056-7)
Neoplasms of whatever cell type or origin, occurring in the extraskeletal connective tissue framework of the body including the organs of locomotion and their various component structures, such as nerves, blood vessels, lymphatics, etc.
Institutions specializing in the care of cancer patients.
An anaplastic, highly malignant, and usually bronchogenic carcinoma composed of small ovoid cells with scanty neoplasm. It is characterized by a dominant, deeply basophilic nucleus, and absent or indistinct nucleoli. (From Stedman, 25th ed; Holland et al., Cancer Medicine, 3d ed, p1286-7)
Benign and malignant neoplasms which occur within the substance of the spinal cord (intramedullary neoplasms) or in the space between the dura and spinal cord (intradural extramedullary neoplasms). The majority of intramedullary spinal tumors are primary CNS neoplasms including ASTROCYTOMA; EPENDYMOMA; and LIPOMA. Intramedullary neoplasms are often associated with SYRINGOMYELIA. The most frequent histologic types of intradural-extramedullary tumors are MENINGIOMA and NEUROFIBROMA.
An antineoplastic antimetabolite with immunosuppressant properties. It is an inhibitor of TETRAHYDROFOLATE DEHYDROGENASE and prevents the formation of tetrahydrofolate, necessary for synthesis of thymidylate, an essential component of DNA.
A set of techniques used when variation in several variables has to be studied simultaneously. In statistics, multivariate analysis is interpreted as any analytic method that allows simultaneous study of two or more dependent variables.
Works about pre-planned studies of the safety, efficacy, or optimum dosage schedule (if appropriate) of one or more diagnostic, therapeutic, or prophylactic drugs, devices, or techniques selected according to predetermined criteria of eligibility and observed for predefined evidence of favorable and unfavorable effects. This concept includes clinical trials conducted both in the U.S. and in other countries.
Antimetabolites that are useful in cancer chemotherapy.
Computed tomography modalities which use a cone or pyramid-shaped beam of radiation.
A relatively slow-growing glioma that is derived from oligodendrocytes and tends to occur in the cerebral hemispheres, thalamus, or lateral ventricle. They may present at any age, but are most frequent in the third to fifth decades, with an earlier incidence peak in the first decade. Histologically, these tumors are encapsulated, relatively avascular, and tend to form cysts and microcalcifications. Neoplastic cells tend to have small round nuclei surrounded by unstained nuclei. The tumors may vary from well-differentiated to highly anaplastic forms. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, p2052; Adams et al., Principles of Neurology, 6th ed, p655)
The return of a sign, symptom, or disease after a remission.
Any of a group of malignant tumors of lymphoid tissue that differ from HODGKIN DISEASE, being more heterogeneous with respect to malignant cell lineage, clinical course, prognosis, and therapy. The only common feature among these tumors is the absence of giant REED-STERNBERG CELLS, a characteristic of Hodgkin's disease.
The surgical removal of the eyeball leaving the eye muscles and remaining orbital contents intact.
The compound is given by intravenous injection to do POSITRON-EMISSION TOMOGRAPHY for the assessment of cerebral and myocardial glucose metabolism in various physiological or pathological states including stroke and myocardial ischemia. It is also employed for the detection of malignant tumors including those of the brain, liver, and thyroid gland. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1162)
Acute and chronic conditions characterized by external mechanical compression of the SPINAL CORD due to extramedullary neoplasm; EPIDURAL ABSCESS; SPINAL FRACTURES; bony deformities of the vertebral bodies; and other conditions. Clinical manifestations vary with the anatomic site of the lesion and may include localized pain, weakness, sensory loss, incontinence, and impotence.
Tumors or cancer of the ANAL CANAL.
The worsening of a disease over time. This concept is most often used for chronic and incurable diseases where the stage of the disease is an important determinant of therapy and prognosis.
A cell line derived from cultured tumor cells.
Tumor or cancer of the female reproductive tract (GENITALIA, FEMALE).
A performance measure for rating the ability of a person to perform usual activities, evaluating a patient's progress after a therapeutic procedure, and determining a patient's suitability for therapy. It is used most commonly in the prognosis of cancer therapy, usually after chemotherapy and customarily administered before and after therapy. It was named for Dr. David A. Karnofsky, an American specialist in cancer chemotherapy.
Tumors or cancer of the PHARYNX.
A malignant neoplasm that may be classified either as a glioma or as a primitive neuroectodermal tumor of childhood (see NEUROECTODERMAL TUMOR, PRIMITIVE). The tumor occurs most frequently in the first decade of life with the most typical location being the cerebellar vermis. Histologic features include a high degree of cellularity, frequent mitotic figures, and a tendency for the cells to organize into sheets or form rosettes. Medulloblastoma have a high propensity to spread throughout the craniospinal intradural axis. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2060-1)
A radiosensitive, malignant neoplasm of the testis, thought to be derived from primordial germ cells of the sexually undifferentiated embryonic gonad. There are three variants: classical (typical), the most common type; anaplastic; and spermatocytic. The classical seminoma is composed of fairly well differentiated sheets or cords of uniform polygonal or round cells (seminoma cells), each cell having abundant clear cytoplasm, distinct cell membranes, a centrally placed round nucleus, and one or more nucleoli. In the female, a grossly and histologically identical neoplasm, known as dysgerminoma, occurs. (Dorland, 27th ed)
Benign and malignant intra-axial tumors of the MESENCEPHALON; PONS; or MEDULLA OBLONGATA of the BRAIN STEM. Primary and metastatic neoplasms may occur in this location. Clinical features include ATAXIA, cranial neuropathies (see CRANIAL NERVE DISEASES), NAUSEA, hemiparesis (see HEMIPLEGIA), and quadriparesis. Primary brain stem neoplasms are more frequent in children. Histologic subtypes include GLIOMA; HEMANGIOBLASTOMA; GANGLIOGLIOMA; and EPENDYMOMA.
An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.
The period following a surgical operation.
Primary or metastatic neoplasms of the CEREBELLUM. Tumors in this location frequently present with ATAXIA or signs of INTRACRANIAL HYPERTENSION due to obstruction of the fourth ventricle. Common primary cerebellar tumors include fibrillary ASTROCYTOMA and cerebellar HEMANGIOBLASTOMA. The cerebellum is a relatively common site for tumor metastases from the lung, breast, and other distant organs. (From Okazaki & Scheithauer, Atlas of Neuropathology, 1988, p86 and p141)
Surgical excision of one or more lymph nodes. Its most common use is in cancer surgery. (From Dorland, 28th ed, p966)
Neoplasms of the bony orbit and contents except the eyeball.
Molecular products metabolized and secreted by neoplastic tissue and characterized biochemically in cells or body fluids. They are indicators of tumor stage and grade as well as useful for monitoring responses to treatment and predicting recurrence. Many chemical groups are represented including hormones, antigens, amino and nucleic acids, enzymes, polyamines, and specific cell membrane proteins and lipids.
Penetrating, high-energy electromagnetic radiation emitted from atomic nuclei during NUCLEAR DECAY. The range of wavelengths of emitted radiation is between 0.1 - 100 pm which overlaps the shorter, more energetic hard X-RAYS wavelengths. The distinction between gamma rays and X-rays is based on their radiation source.
Glioma derived from EPENDYMOGLIAL CELLS that tend to present as malignant intracranial tumors in children and as benign intraspinal neoplasms in adults. It may arise from any level of the ventricular system or central canal of the spinal cord. Intracranial ependymomas most frequently originate in the FOURTH VENTRICLE and histologically are densely cellular tumors which may contain ependymal tubules and perivascular pseudorosettes. Spinal ependymomas are usually benign papillary or myxopapillary tumors. (From DeVita et al., Principles and Practice of Oncology, 5th ed, p2018; Escourolle et al., Manual of Basic Neuropathology, 2nd ed, pp28-9)
Antineoplastic agents that are used to treat hormone-sensitive tumors. Hormone-sensitive tumors may be hormone-dependent, hormone-responsive, or both. A hormone-dependent tumor regresses on removal of the hormonal stimulus, by surgery or pharmacological block. Hormone-responsive tumors may regress when pharmacologic amounts of hormones are administered regardless of whether previous signs of hormone sensitivity were observed. The major hormone-responsive cancers include carcinomas of the breast, prostate, and endometrium; lymphomas; and certain leukemias. (From AMA Drug Evaluations Annual 1994, p2079)
Discrete concentrations of energy, apparently massless elementary particles, that move at the speed of light. They are the unit or quantum of electromagnetic radiation. Photons are emitted when electrons move from one energy state to another. (From Hawley's Condensed Chemical Dictionary, 11th ed)
The ratio of radiation dosages required to produce identical change based on a formula comparing other types of radiation with that of gamma or roentgen rays.
A malignant solid tumor arising from mesenchymal tissues which normally differentiate to form striated muscle. It can occur in a wide variety of sites. It is divided into four distinct types: pleomorphic, predominantly in male adults; alveolar (RHABDOMYOSARCOMA, ALVEOLAR), mainly in adolescents and young adults; embryonal (RHABDOMYOSARCOMA, EMBRYONAL), predominantly in infants and children; and botryoidal, also in young children. It is one of the most frequently occurring soft tissue sarcomas and the most common in children under 15. (From Dorland, 27th ed; Holland et al., Cancer Medicine, 3d ed, p2186; DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, pp1647-9)
Tumors of the choroid; most common intraocular tumors are malignant melanomas of the choroid. These usually occur after puberty and increase in incidence with advancing age. Most malignant melanomas of the uveal tract develop from benign melanomas (nevi).
Tumors or cancer of the EYE.
Abnormally high temperature intentionally induced in living things regionally or whole body. It is most often induced by radiation (heat waves, infra-red), ultrasound, or drugs.
Dissection in the neck to remove all disease tissues including cervical LYMPH NODES and to leave an adequate margin of normal tissue. This type of surgery is usually used in tumors or cervical metastases in the head and neck. The prototype of neck dissection is the radical neck dissection described by Crile in 1906.
Persons who have experienced a prolonged survival after serious disease or who continue to live with a usually life-threatening condition as well as family members, significant others, or individuals surviving traumatic life events.
Pathological processes of the male URINARY TRACT and the reproductive system (GENITALIA, MALE).
Ability of neoplasms to infiltrate and actively destroy surrounding tissue.
Irradiation of one half or both halves of the body in the treatment of disseminated cancer or widespread metastases. It is used to treat diffuse metastases in one session as opposed to multiple fields over an extended period. The more frequent treatment modalities are upper hemibody irradiation (UHBI) or lower hemibody irradiation (LHBI). Less common is mid-body irradiation (MBI). In the treatment of both halves of the body sequentially, hemibody irradiation permits radiotherapy of the whole body with larger doses of radiation than could be accomplished with WHOLE-BODY IRRADIATION. It is sometimes called "systemic" hemibody irradiation with reference to its use in widespread cancer or metastases. (P. Rubin et al. Cancer, Vol 55, p2210, 1985)
The qualitative or quantitative estimation of the likelihood of adverse effects that may result from exposure to specified health hazards or from the absence of beneficial influences. (Last, Dictionary of Epidemiology, 1988)
Devices or objects in various imaging techniques used to visualize or enhance visualization by simulating conditions encountered in the procedure. Phantoms are used very often in procedures employing or measuring x-irradiation or radioactive material to evaluate performance. Phantoms often have properties similar to human tissue. Water demonstrates absorbing properties similar to normal tissue, hence water-filled phantoms are used to map radiation levels. Phantoms are used also as teaching aids to simulate real conditions with x-ray or ultrasonic machines. (From Iturralde, Dictionary and Handbook of Nuclear Medicine and Clinical Imaging, 1990)
Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).
Remnant of a tumor or cancer after primary, potentially curative therapy. (Dr. Daniel Masys, written communication)
Experimentally produced harmful effects of ionizing or non-ionizing RADIATION in CHORDATA animals.
Positional isomer of CYCLOPHOSPHAMIDE which is active as an alkylating agent and an immunosuppressive agent.
Small-scale tests of methods and procedures to be used on a larger scale if the pilot study demonstrates that these methods and procedures can work.
Difficulty in SWALLOWING which may result from neuromuscular disorder or mechanical obstruction. Dysphagia is classified into two distinct types: oropharyngeal dysphagia due to malfunction of the PHARYNX and UPPER ESOPHAGEAL SPHINCTER; and esophageal dysphagia due to malfunction of the ESOPHAGUS.
Tumors of cancer of the EYELIDS.
Works about clinical trials that involve at least one test treatment and one control treatment, concurrent enrollment and follow-up of the test- and control-treated groups, and in which the treatments to be administered are selected by a random process, such as the use of a random-numbers table.

Use of positron emission tomography in evaluation of brachial plexopathy in breast cancer patients. (1/2648)

18-Fluoro-2-deoxyglucose (FDG) positron emission tomography (PET) has previously been used successfully to image primary and metastatic breast cancer. In this pilot study, 19 breast cancer patients with symptoms/signs referrable to the brachial plexus were evaluated with 18FDG-PET. In 11 cases computerized tomography (CT) scanning was also performed. Of the 19 patients referred for PET study, 14 had abnormal uptake of 18FDG in the region of the symptomatic plexus. Four patients had normal PET studies and one had increased FDG uptake in the chest wall that accounted for her axillary pain. CT scans were performed in 9 of the 14 patients who had positive brachial plexus PET studies; six of these were either normal or showed no clear evidence of recurrent disease, while three CTs demonstrated clear brachial plexus involvement. Of two of the four patients with normal PET studies, one has had complete resolution of symptoms untreated while the other was found to have cervical disc herniation on magnetic resonance imaging (MRI) scan. The remaining two patients almost certainly had radiation-induced plexopathy and had normal CT, MRI and PET study. These data suggest that 18FDG-PET scanning is a useful tool in evaluation of patients with suspected metastatic plexopathy, particularly if other imaging studies are normal. It may also be useful in distinguishing between radiation-induced and metastatic plexopathy.  (+info)

Quality of life and performance in advanced head and neck cancer patients on concomitant chemoradiotherapy: a prospective examination. (2/2648)

PURPOSE: To prospectively evaluate performance and quality of life (QOL) in advanced-stage head and neck cancer (HNC) patients on a curative-intent, concomitant-chemoradiotherapy (CT/XRT) (twice-daily radiation, fluorouracil, hydroxyurea, and cisplatin) regimen aimed at improving locoregional control, survival, and QOL. PATIENTS AND METHODS: Sixty-four patients were assessed before, during, and at 3-month intervals after treatment. Standardized measures of QOL (Functional Assessment of Cancer Therapy-Head and Neck), performance (Performance Status Scale for Head and Neck Cancer Patients and Karnofsky Performance Status Rating Scale), and patient-reported symptoms (McMaster University Head and Neck Radiotherapy Questionnaire) were administered. RESULTS: Acute treatment toxicities were severe, with declines in virtually all QOL and functional domains. Marked improvement was seen by 12 months; general functional and physical measures returned to baseline levels of good to excellent. Although up to a third of the patients continued to report problems with swallowing, hoarseness, and mouth pain, these difficulties were present in similar magnitudes before treatment. The following symptoms were more frequent at 12 months: dry mouth (58% v 17%), difficulties tasting (32% v 8%), and soft food diet (82% v 42%). Twelve-month diet was not related to pretreatment functioning, disease, treatment, or patient characteristics. Twelve-month QOL was best predicted by pretreatment QOL, with very little relationship to residual side effects or functional impairments. Small numbers of patients in four of the five disease sites precluded examination of outcome by site. CONCLUSION: These data support the feasibility of intense CT/XRT as primary treatment for advanced HNC. Results confirm acute toxicity but indicate that many of the treatment-related performance and QOL declines resolve by 12 months. The persistent inability to eat a full range of foods warrants further attention and monitoring.  (+info)

p53 and p16INK4A mutations during the progression of glomus tumor. (3/2648)

Glomus tumors are significantly rare tumors of carotid body. The great majority of these tumors are benign in character. Here we present two brothers with hereditary glomus jugulare tumor who had consanguineous parents. Radiotherapy was applied approximately 8 and 10 years ago for treatment in both cases. Eight years later, one of these cases came to our notice due to relapse. The mutation pattern of p53, p57KIP2, p16INK4A and p15NK4B genes which have roles in the cell cycle, was analyzed in tumor samples obtained from the two affected cases in the initial phase and from one of these cases at relapse. The DNA sample obtained from the case in initial diagnosis phase revealed no p53, p57KIP2, p16INK4A or p15INK4B mutation. He is still in remission phase. Despite the lack of p53, p57KIP2, p16INK4A and p15INK4B mutation at initial diagnosis the tumor DNA of the other case in relapse revealed p53 codon 243 (ATG-->ATC; met-->ile) and p16 codon 97 (GAC-->AAC; asp-->asn) missense point mutations. No loss of heterozygosity in p53 and p16INK4A was observed by microsatellite analysis of tumoral tissues in these cases. P53 and p16INK4A mutations observed in relapse phase were in conserved regions of both genes. No previous reports have been published with these mutations in glomus tumor during progression. The mutation observed in this case may due to radiotherapy. In spite of this possibility, the missense point mutations in conserved region of p53 and p16INK4A genes may indicate the role of p53 and p16INK4A in tumor progression of glomus tumors.  (+info)

Radiation induced endothelial cell retraction in vitro: correlation with acute pulmonary edema. (4/2648)

We determined the effects of low dose radiation (<200 cGy) on the cell-cell integrity of confluent monolayers of pulmonary microvascular endothelial cells (PMEC). We observed dose- and time-dependent reversible radiation induced injuries to PMEC monolayers characterized by retraction (loss of cell-cell contact) mediated by cytoskeletal F-actin reorganization. Radiation induced reorganization of F-actin microfilament stress fibers was observed > or =30 minutes post irradiation and correlated positively with loss of cell-cell integrity. Cells of irradiated monolayers recovered to form contact inhibited monolayers > or =24 hours post irradiation; concomitantly, the depolymerized microfilaments organized to their pre-irradiated state as microfilament stress fibers arrayed parallel to the boundaries of adjacent contact-inhibited cells. Previous studies by other investigators have measured slight but significant increases in mouse lung wet weight >1 day post thoracic or whole body radiation (> or =500 cGy). Little or no data is available concerning time intervals <1 day post irradiation, possibly because of the presumption that edema is mediated, at least in part, by endothelial cell death or irreversible loss of barrier permeability functions which may only arise 1 day post irradiation. However, our in vitro data suggest that loss of endothelial barrier function may occur rapidly and at low dose levels (< or =200 cGy). Therefore, we determined radiation effects on lung wet weight and observed significant increases in wet weight (standardized per dry weight or per mouse weight) in < or =5 hours post thoracic exposure to 50 200 cGy x-radiation. We suggest that a single fraction of radiation even at low dose levels used in radiotherapy, may induce pulmonary edema by a reversible loss of endothelial cell-cell integrity and permeability barrier function.  (+info)

When to consider radiation therapy for your patient. (5/2648)

Radiation therapy can be an effective treatment modality for both malignant and benign disease. While radiation can be given as primary treatment, it may also be used pre- or postoperatively, with or without other forms of therapy. Radiation therapy is often curative but is sometimes palliative. There are many methods of delivering radiation effectively. Often, patients tolerate irradiation well without significant complications, and organ function is preserved. To ensure that all patients with cancer have the opportunity to consider all treatment options, family physicians should be aware of the usefulness of radiation therapy.  (+info)

Diagnostic and therapeutic approaches for nonmetastatic breast cancer in Canada, and their associated costs. (6/2648)

In an era of fiscal restraint, it is important to evaluate the resources required to diagnose and treat serious illnesses. As breast cancer is the major malignancy affecting Canadian women, Statistics Canada has analysed the resources required to manage this disease in Canada, and the associated costs. Here we report the cost of initial diagnosis and treatment of nonmetastatic breast cancer, including adjuvant therapies. Treatment algorithms for Stages I, II, and III of the disease were derived by age group (< 50 or > or = 50 years old), principally from Canadian cancer registry data, supplemented, where necessary, by the results of surveys of Canadian oncologists. Data were obtained on breast cancer incidence by age, diagnostic work-up, stage at diagnosis, initial treatment, follow-up practice, duration of hospitalization and direct care costs. The direct health care costs associated with 'standard' diagnostic and therapeutic approaches were calculated for a cohort of 17,700 Canadian women diagnosed in 1995. Early stage (Stages I and II) breast cancer represented 87% of all incident cases, with 77% of cases occurring in women > or = 50 years. Variations were noted in the rate of partial vs total mastectomy, according to stage and age group. Direct costs for diagnosis and initial treatment ranged from $8014 for Stage II women > or = 50 years old, to $10,897 for Stage III women < 50 years old. Except for Stage III women < 50 years old, the largest expenditure was for hospitalization for surgery, followed by radiotherapy costs. Chemotherapy was the largest cost component for Stage III women < 50 years old. This report describes the cost of diagnosis and initial treatment of nonmetastatic breast cancer in Canada, assuming current practice patterns. A second report will describe the lifetime costs of treating all stages of breast cancer. These data will then be incorporated into Statistics Canada's Population Health Model (POHEM) to perform cost-effectiveness studies of new therapeutic interventions for breast cancer, such as the cost-effectiveness of day surgery, or of radiotherapy to all breast cancer patients undergoing breast surgery.  (+info)

In vitro assessment of Lipiodol-targeted radiotherapy for liver and colorectal cancer cell lines. (7/2648)

Intra-arterial Lipiodol has been used to deliver targeted therapies to primary, and some metastatic, liver cancers. Targeted radiotherapy has been used by substituting the iodine in Lipiodol with 131Iodine (131I). Early clinical results are encouraging, but the variable response may partly depend on local pharmacokinetics. This study evaluated the in vitro cytotoxic effects of 131I-Lipiodol on human hepatocellular carcinoma (Hep-G2), human colorectal metastatic cancer (SW620), human colorectal hepatic cancer (LoVo) and human umbilical vein endothelial cells (HUVEC) cell lines. The cell cultures were exposed to 131I-Lipiodol for 48 h, following which cell counts and viability were assessed by haemocytometer, S-Rhodamine uptake and radioactivity assay. The effect of exposure to control Lipiodol, 131I-Lipiodol and 131I alone was evaluated. 131I-Lipiodol was cytotoxic against all the cancer cell lines but not against the non-malignant (HUVEC) cell line. The cytotoxicity effects were very similar in all the cancer cell lines. There were no cytotoxic effects following exposure to plain 131I in any of the cell lines (malignant and non-malignant). A similar trend was seen with radioactivity counts using a gamma counter. The cytotoxic effect of 131I-Lipiodol had a graded effect with an increase in cytotoxicity following the increase in the radioactive dose. This study showed that there was a marked cytotoxic effect by 131I-Lipiodol on all the cancer cell lines. There was no difference between the controls and the 131Iodine. This suggests that effective 131I-Lipiodol targeted therapy is dependent on the uptake and retention of Lipiodol by malignant cells.  (+info)

Correlation of bcl-2 rearrangement with clinical characteristics and outcome in indolent follicular lymphoma. (8/2648)

The t(14;18) translocation, which involves the bcl-2 oncogene, occurs in follicular lymphomas (FL) at two common sites: the major breakpoint region (MBR) and the minor cluster region (mcr). The biological and clinical significance of these breakpoints is unknown. The bcl-2 breakpoint site was determined in 247 previously untreated patients (49% men; median age 52 years) with indolent FL (155 grade I, 83 grade II, and 8 grade III) to correlate it with pretreatment characteristics, response, and outcome. The bcl-2 breakpoint site was determined by a polymerase chain reaction method of peripheral blood (all cases), bone marrows (149 cases), and fresh lymph node biopsy specimens (68 cases). The breakpoint site occurred at MBR in 175 cases (71%) and at mcr in 27 (11%). In 45 cases (18%), no breakpoint was detected (germline). No significant relationship was found between the rearrangements and the expression of BLC-2 and BAX proteins. Patients' germline for MBR and mcr tended to present more frequently with stage IV disease and higher beta2-microglobulin (beta2M) levels, whereas mcr-rearranged patients presented more frequently with early stage and normal beta2M. The complete response rate of germline patients was significantly lower than that of MBR and mcr patients. An estimated 3-year failure-free survival (FFS) for mcr, MBR, and germline cases was 95%, 76%, and 57%, respectively (P <.001). The bcl-2 breakpoint site was independent of serum beta2M and lactate dehydrogenase in its correlation with FFS. In conclusion, the bcl-2 rearrangement site is an important prognostic factor in indolent FL, useful to identify patients who may require different treatment.  (+info)

Principles and Practice of Modern Radiotherapy Techniques in Breast Cancer by Ayfer Haydaroglu. Read online, or download in secure PDF format
The Scientific basis of modern radiotherapy: an international symposium to mark the achievements of John Francis Fowler ... held in the Fowler-Scott Library of the Cancer Research Campaign Gray Laboratory, Northwood, Middlesex, 30th June-2nd July 1988 ...
The Scientific basis of modern radiotherapy: an international symposium to mark the achievements of John Francis Fowler ... held in the Fowler-Scott Library of the Cancer Research Campaign Gray Laboratory, Northwood, Middlesex, 30th June-2nd July 1988 ...
Today women ask us not only to be cured but also the preservation of their body; this is one of our most important endpoints in modern radiotherapy treatments. The radiotherapy-induced skin toxicity remains a major clinical problem that affects many patients with breast cancer undergoing adjuvant radiotherapy [18]. Anyway there is a growing emphasis on prevention and treatment of side effects induced by radiation therapy; this attention has derived many studies dealing about the treatments and substances that can protect healthy organs from radiation therapy side effects.. Surely the breast volume has a great impact on the incidence and the level of skin toxicity, but also the breast volume receiving dose-points equal or greater than 107% of the one prescribed has an impact in the arising of side effects. Thats because many studies aimed to find appropriate prevention methods for damages are born. These methods seemed to be helpful in 25% of patients with breast cancer who presented a high ...
Radiotherapy is a type of treatment that uses pulses of radiation to destroy cancer cells. There are a number of ways it can be used to treat people with lung cancer.. An intensive course of radiotherapy, known as radical radiotherapy, can be used to try to cure non-small-cell lung cancer if the person isnt healthy enough for surgery. For very small tumours, a special type of radiotherapy called stereotactic radiotherapy may be used instead of surgery.. Radiotherapy can also be used to control the symptoms and slow the spread of cancer when a cure isnt possible (this is known as palliative radiotherapy).. A type of radiotherapy known as prophylactic cranial irradiation (PCI) is also sometimes used during the treatment of small-cell lung cancer. PCI involves treating the whole brain with a low dose of radiation. Its used as a preventative measure because theres a risk that small-cell lung cancer will spread to your brain.. The three main ways that radiotherapy can be given are described ...
Polls show that the public do not recognise radiotherapy as a modern form of cancer therapy, and many would describe it as frightening. Yet radiotherapy is one of the most effective cancer treatments available, and a staggering array of new developments should allow radiotherapy to become increasingly personalised to individual cancer patients.. Major advances, such as Intensity Modulated Radiotherapy (IMRT), proton therapy, Cyberknife technology and research combining radiotherapy with MRI imaging, viral therapy, and chemotherapy, promise to revolutionise radiotherapy in the future.. Leading experts in radiotherapy came to the SMC discuss things such as:. ...
Results Out of the 12 patients in the study, 6 did not receive radiotherapy either because they elected for subsequent radical surgery (3 patients) or were unfit for further treatment and underwent close follow-up (3 patients).. In the radiotherapy group, 2 patients had pre-op Long-Course Chemo-radiotherapy (LCCRT) with a good partial response, 2 were included in the national TEM and Radiotherapy in Early Rectal cancer (TREC) trial and had pre-op Short Course radiotherapy (SCRT) and 2 had adjuvant LCCRT + Papillon contact radiotherapy following TEM.. Median follow-up was 20 months. Patients not undergoing radial surgery had 3 monthly MR and sigmoidoscopy for 1 year and 6 monthly MR and sigmoidoscopy for a further 2 years.. In the no-radiotherapy group, 1 of the 3 patients who underwent subsequent radical surgery had involved mesorectal lymph nodes and 1 of those undergoing close follow-up without radical surgery developed mesorectal nodal recurrence. In radiotherapy group 1 patient, in the TREC ...
Post-operative radiotherapy is internationally accepted as standard practice in the management of high-risk endometrial cancer1. Whilst it has no proven impact on overall survival it significantly increases local control.. Conventional radiotherapy techniques (3-dimensional) utilise a 3 or 4 field beam arrangement to target the pelvis in order to treat those areas at risk of recurrence: the vagina, the parametrium and the pelvic lymph nodes. However, when using such a technique it is not possible to avoid irradiating sensitive normal tissues such as the bowel and bladder.. Toxicity data from international randomised control trials in endometrial cancer report significantly more haematological, gastrointestinal, genitourinary and cutaneous toxicites (all grades) in those who received pelvic irradiation compared to those who did not2,3. These trials delivered radiotherapy using 2 or 3-dimensional techniques.. Intensity Modulated Radiation Therapy (IMRT) is a newer but established radiotherapy ...
Post-radiation fractures after radiotherapy are prevalent in specific anatomic locations, such as the pelvis following urologic or gynecologic cancer treatment,...
Modern radiotherapy machines can now deliver highly targeted radiotherapy treatment. However, the use of high precision radiotherapy techniques is extremely demanding in terms of hours spent, from the physician who defines the tumour target and healthy tissues, to the physicist who has to calculate a plan of optimum beam angles and trajectories for the treatment, and the radiographer, who must ensure that the treatment is delivered accurately to the target every day during a six or seven week course of radiotherapy. Accel-RT is an innovative partnership between oncologists, physicists and computer scientists at the Universities of Cambridge and Oxford. Over the next three years the collaborators will develop software tools and processes that will speed up the process of planning of radiotherapy. Once completed, free software tools will be available to radiotherapy treatment centres. These tools will increase patient access to high precision radiotherapy by reducing the bottle-necks in the ...
A detailed analysis of developments observed in products and technologies over the review period, development status of key counties operating in the international Radiotherapy Equipments market, development status of key regions in Radiotherapy Equipments market, and a comparison of international and China Radiotherapy Equipments market are also included.. Download Sample [email protected] https://www.researchnreports.com/request_sample.php?id=130791. The report is characterized into numerous parts dealing with diverse aspects of the Radiotherapy Equipments market. This research report inspects the present situation and development prognosis of the Radiotherapy Equipments market around the globe during the forecasting horizon. To determine the market size, the report analyzes revenue produced in the Radiotherapy Equipments market worldwide alongside demonstrating the segmentation of the prime producers.. Ask Your Query/Enquiry for this ...
Request for buying: Global Radiotherapy Market - Industry Trends and Forecast to 2024. Table of Contents:. 1. INTRODUCTION. 1.1. OVERVIEW OF THE GLOBAL RADIOTHERAPY MARKET. 1.2. MARKET SEGMENTATION & COVERAGE. 1.2.1. CURRENCY AND PRICING. 1.2.2. LIMITATION. 1.2.3. STAKEHOLDERS. 2. RESEARCH METHODOLOGY. 2.1. KEY TAKEAWAYS. 2.2. ARRIVING AT THE GLOBAL RADIOTHERAPY MARKET SIZE. 2.2.1. MARKET CRACKDOWN APPROACH. 2.2.2. COMPANY REVENUE AND MARKET SHARE ANALYSIS. 2.2.3. DATA TRIANGULATION. 2.2.4. KEY DATA POINTS FROM PRIMARY SOURCES. 2.2.5. PRODUCT PIPELINE ANALYSIS. 2.2.6. PORTERS FIVE FORCES MATRIX. 2.3. GLOBAL RADIOTHERAPY MARKET: RESEARCH SNAPSHOT. 2.4. ASSUMPTIONS. 3. MARKET OVERVIEW. 4. EXECUTIVE SUMMARY. 4.1. OVERVIEW. 4.2. GLOBAL RADIOTHERAPY MARKET: KEY PRIMARY INSIGHTS. 4.3. MARKET OVERVIEW. 4.3.1. DRIVERS. 4.3.2. RESTRAINTS. 4.3.3. OPPURTUNITIES. 4.3.4. THREATS. 4.4. KEY MARKET TRENDS AND UPCOMING TECHNOLOGIES. 5. GLOBAL RADIOTHERAPY MARKET, BY THERAPY TYPE. 5.1. OVERVIEW. 5.2. BEAM ...
Request for buying: Global Radiotherapy Market - Industry Trends and Forecast to 2024. Table of Contents:. 1. INTRODUCTION. 1.1. OVERVIEW OF THE GLOBAL RADIOTHERAPY MARKET. 1.2. MARKET SEGMENTATION & COVERAGE. 1.2.1. CURRENCY AND PRICING. 1.2.2. LIMITATION. 1.2.3. STAKEHOLDERS. 2. RESEARCH METHODOLOGY. 2.1. KEY TAKEAWAYS. 2.2. ARRIVING AT THE GLOBAL RADIOTHERAPY MARKET SIZE. 2.2.1. MARKET CRACKDOWN APPROACH. 2.2.2. COMPANY REVENUE AND MARKET SHARE ANALYSIS. 2.2.3. DATA TRIANGULATION. 2.2.4. KEY DATA POINTS FROM PRIMARY SOURCES. 2.2.5. PRODUCT PIPELINE ANALYSIS. 2.2.6. PORTERS FIVE FORCES MATRIX. 2.3. GLOBAL RADIOTHERAPY MARKET: RESEARCH SNAPSHOT. 2.4. ASSUMPTIONS. 3. MARKET OVERVIEW. 4. EXECUTIVE SUMMARY. 4.1. OVERVIEW. 4.2. GLOBAL RADIOTHERAPY MARKET: KEY PRIMARY INSIGHTS. 4.3. MARKET OVERVIEW. 4.3.1. DRIVERS. 4.3.2. RESTRAINTS. 4.3.3. OPPURTUNITIES. 4.3.4. THREATS. 4.4. KEY MARKET TRENDS AND UPCOMING TECHNOLOGIES. 5. GLOBAL RADIOTHERAPY MARKET, BY THERAPY TYPE. 5.1. OVERVIEW. 5.2. BEAM ...
radiotherapy Definition, radiotherapy Best Plays of radiotherapy in Scrabble® and Words With Friends, Length tables of words in radiotherapy, Word growth of radiotherapy, Sequences of radiotherapy
In this manuscript, we show that treatment with low doses of fractionated radiotherapy leads to upregulation of PD-L1 expression on tumor cells secondary to CD8+ T-cell production of IFNγ. In models of melanoma, colorectal, and breast cancer, we demonstrate that the efficacy of radiotherapy can be enhanced through combination with αPD-L1 mAb, leading to the generation of memory immunity in LTS mice capable of protecting against tumor recurrence. Furthermore, our data reveal that dose scheduling may be critical for outcome with concurrent but not sequential therapy effective at improving local tumor control and survival.. Recent clinical trials have begun to evaluate blockade of the PD-1/PD-L1 axis with encouraging responses observed in multiple disease settings with mAb targeted against both PD-1 and PD-L1 (18-20, 24, 25). Despite this, combination approaches may be required to improve response rates and to generate durable antitumor immunity. We and others have demonstrated the potential to ...
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details ...
Radiotherapy is used to treat conditions such as cancer, thyroid disorders and some blood disorders. It is used to treat about 40% of people with cancer. The length of each course of radiotherapy depends on the size of the cancer and where it is on the body.. During radiotherapy, controlled doses of high-energy radiation, usually X-rays, destroy cancer cells in the affected area.. Uses of radiotherapy. Radiotherapy is used for a number of different medical purposes including:. ...
A chemotherapy regimen consisting of procarbazine, CCNU, and vincristine administered following radiation therapy improved progression-free survival and overall survival in adults with low-grade gliomas, a form of brain cancer, when compared to radiation therapy alone. The findings were part of the results of a Phase III clinical trial presented today at the 2014 American Society of Clinical Oncology Annual Meeting by the studys primary author Jan Buckner, M.D., deputy director, Cancer Practice, at Mayo Clinic Cancer Center.
Radiotherapy is one of the most common therapeutic methods for treatment of many types of cancer. Despite many decades of development and experience there is much to improve, both in efficacy of treatment and to decrease the incidences of adverse healthy tissue reactions. Around 20 % of the radiotherapy patients show a broad range in the severity of normal tissue reactions to radiotherapy, and dose limits are governed by severe reactions in the most radiosensitive patients (, 5 %). Identification of patients with low, moderate or high clinical radiosensitivity before commencing of radiotherapy would allow individual adaptation of the maximum dose with an overall increase in the cure rate. Characterization of factors that may modify the biological effects of ionizing radiation has been a subject of intense research efforts. Still, there is no assay currently available that can reliably predict the clinical radiosensitivity. The aim of this work has been to investigate the role of oxidative stress ...
Radiotherapy to the breast can sometimes lead to long-term side effects. A few months after radiotherapy some women develop breathlessness (due to the effect of radiotherapy on the lung). This can usually be treated with a short course of steroids. In the longer term there may be some weakness of the ribs in the irradiated area, which makes them more likely to fracture than normal. If you have radiotherapy to your underarm (axilla) there is a very small risk of developing late side effects such as nerve pain, tingling, and weakness or numbness in the arm and hand (peripheral neuropathy ...
MODEL RELEASED. Radiotherapy treatment. Patient undergoing radiotherapy (radiation therapy) for cancer. Radiotherapy is used to treat people with a range of cancers and is often combined with surgery or chemotherapy (drug treatment). - Stock Image C023/5855
The long-term results of the RT01 trial, which looked at whether standard or higher doses of radiotherapy were best for treating localised and locally-advanced prostate cancer, were published in the Lancet Oncology on 26 February 2014.. The trial compared a 7.5 week course of radiotherapy (giving 74 Gy of radiation in total) with a 6.5 week course of radiotherapy (giving 64 Gy of radiation). The results show that, 10 years after treatment, men who had the higher dose of radiotherapy were less likely to have signs of their cancer coming back or getting worse. 55 per cent of men in the higher dose group had no signs of their disease getting worse, compared to 43 per cent who had the standard dose.. Men who received the higher dose were also less likely to need to start treatment with long-term hormone therapy within 10 years.. However, the trial found that there was no difference in how long men treated with the higher or standard doses lived. Men in both groups of the trial lived much longer than ...
This new volume in the Radiotherapy in Practice series provides a comprehensive and evidence-based guide to radiotherapy in the management of children and young people with cancer. It explains the roles of the various modalities of treatment available, including image-guided and intensity modulated radiotherapy, brachytherapy, proton beam therapy, and molecular radiotherapy, and aids selection of the most appropriate technique in different situations.
Back in 2016 I was diagnosed with a rare form of Bowel Cancer, there were only 2 cases of it at the hospital where I was under. My Oncologist explained all the details about the diagnosis but I think I found out more by doing my own research. As a part of my treatment I was offered chemo-radiation, this is a treatment that means I was to have radiotherapy alongside taking chemotherapy tablets.. Radiotherapy is the use of controlled, high - energy radiation. It is offered alongside chemotherapy as it makes the cancerous cells more sensitive to the radiation.. I was told that I would have radiotherapy first to try to shrink the tumour before surgery, as this would make it easier for the surgeon to remove it. My tumor measured at 3 cms and was close to my rectum, sitting on the sphincter muscle - which controlled the movement of the bowel. The tumor was very close to the skin, so close that it could be felt from the outside.. From receiving my diagnosis til the first day of my radiotherapy it took ...
MODEL RELEASED. Radiotherapy. Patient being prepared for radiotherapy. Laser cross-hairs are being aimed onto the site of her brain tumour. Once targeted, a radiotherapy machine will focus radiation at the tumour. The radiation will stop the tumours growth and hopefully destroy it. Brain tumours are abnormal growths in or on the brain that may or may not be cancerous. However, the pressure build-up they cause can be extremely serious and so they must be destroyed using radiotherapy. - Stock Image M705/0141
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The modern day radiotherapy treatments are almost exclusively based on computed tomography (CT) images. The CT images are acquired using x-rays, and therefore reflect the radiation interaction properties of the material. This information is used to perform accurate dose calculation by the treatment planning system, and the data is also well suited for creating digitally reconstructed radiographs for comparing patient set up at the treatment machine where x-ray images are routinely acquired for this purpose.. The magnetic resonance (MR) scanner has many attractive features for radiotherapy purposes. The soft tissue contrast as compared to CT is far superior, and it is possible to vary the sequences in order to visualize different anatomical and physiological properties of an organ. Both of these properties may contribute to an increase in accuracy of radiotherapy treatment.. Using the MR images by themselves for treatment planning is, however, problematic. MR data reflects the magnetic properties ...
Of 178 eligible patients, 141 (79%) had localized disease and 37 (21%) had metastases at presentation. Their 5-year EFS was 51% (SE 5%) and 23% (SE 7%) respectively. The response rate to induction chemotherapy was 88% (28% complete, 60% partial), but after radiotherapy the response rate increased to 98%. Thirty-seven of the localized patients underwent resection, of whom 16 (43%) required postoperative radiotherapy; the 5-year EFS of these surgical patients was 80% (SE 7%). The remaining 104 localized patients were eligible for randomization or assignment to receive radiotherapy; the 5-year EFS of these patients was 41% (SE 5%), with no significant difference in EFS between those randomized to SF vs. IF. Site of primary tumor correlated with 5-year EFS: distal extremity 65% (SE 8%), central 63% (SE 10%), proximal extremity 46% (SE 8%), and pelvic-sacral 24% (SE 10%) (p=0.004). Initial tumor size did not correlate significantly with EFS. Patterns of failure among the 141 localized patients ...
A Canadian research team announced that it has found the reason for the appearance of pulmonary fibrosis in a number of lung cancer patients who underwent thoracic radiotherapy. They found a connection between genes on a certain chromosome and the development of lung injuries triggered by radiation. The researchers were investigating chromosome 6, one of the 23 pairs of DNA molecules found […]
Being told that one has Cancer is not much fun, and when I was diagnosed nearly 18 months ago it was inevitably a shock. This was compounded by the certainty of an operation (double mastectomy), possibility of chemotherapy and almost certainty of Radiotherapy.. The Chemo I escaped, the operation went well, but it was the anticipation of the Radiotherapy which, for me, presented the worst fears. It was not a fear of nuclear medicine, it was the side-effects: I was almost promised these...blistering, weeping skin, bright red and extremely itchy patches around the treated areas. The fact that these things would blow up AFTER the treatment was ended made it seem worse, treatment that in itself was fairly grim - having to lie unnaturally still for what seemed like ages: having ones body heaved around to position it and not being allowed to help - incredibly undignified.. It was just before I started Radiotherapy, however, that I was introduced to someone who had travelled an identical path to ...
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Radiotherapy has been considered a local modality and outcomes have emphasized local and regional control of tumors. Recent data suggests that radiotherapy may activate the immune system and the combination of radiation therapy and immune therapies may have the potential to improve both local and distant control of tumor deposits. Below we review principals underlying the concepts of combining both modalities.
Radiotherapy, as part of initial first cancer management included external beam, brachytherapy or a combination of both. There was a variation in the use of radiotherapy across various cancer types. In this cohort, 60-80% of testicular (seminomas), brain, anal and laryngeal cancers were treated with radiotherapy, whereas less than 30% of non-small-cell lung and eye & orbit cancers were managed with radiotherapy. Yet, for every cancer type analyzed, the risk of second cancer was significant (Relative Risk, RR,1); the highest risk was for testicular (34%) and cervical(17%) cancers. However, of all the second cancers, only 8% could be attributed to radiotherapy during first cancer management. This is a much smaller percent than expected, and is a very good news for the radiology community. It helps communicate long-term risk of radiotherapy with respect to the potential benefit of tumor control and patient survival. Furthermore, the overall risk also decreases with time and by 15 years after the ...
Radiotherapy, as part of initial first cancer management included external beam, brachytherapy or a combination of both. There was a variation in the use of radiotherapy across various cancer types. In this cohort, 60-80% of testicular (seminomas), brain, anal and laryngeal cancers were treated with radiotherapy, whereas less than 30% of non-small-cell lung and eye & orbit cancers were managed with radiotherapy. Yet, for every cancer type analyzed, the risk of second cancer was significant (Relative Risk, RR,1); the highest risk was for testicular (34%) and cervical(17%) cancers. However, of all the second cancers, only 8% could be attributed to radiotherapy during first cancer management. This is a much smaller percent than expected, and is a very good news for the radiology community. It helps communicate long-term risk of radiotherapy with respect to the potential benefit of tumor control and patient survival. Furthermore, the overall risk also decreases with time and by 15 years after the ...
All radiotherapy is targeted towards the tumour, but by using complex computer models the focus of this targeting can be improved (stereotactic radiotherapy). This approach allows a higher dose to be administered in a shorter time with the same side-effects. Cyberknife is an example of this form of therapy. While there are potential advantages from shorter treatment courses and perhaps fewer side-effects, there is no evidence as yet that it is more effective than standard treatments.. ...
The first radiotherapy treatment took place today. Ive been told the main side effect to expect is soreness and Ive got to be careful to use aqueous cream regularly and be careful when washing and drying. No swimming during the treatments or for a couple of weeks afterwards. So there goes my plan to combine radiotherapy and swims at Ironmonger row baths ...
/PRNewswire/ -- CIVCO Radiotherapy, the leading global provider of high quality, innovative, patient-centric radiotherapy solutions, announced today they are...
(PharmaNewsWire.Com, February 14, 2018 ) In this report, Global radiotherapy market is projected to reach USD 9.3 billion by 2024 from USD 5.2 billion in 2016, at a CAGR of 7.5% in the forecast period 2017 to 2024. Based on geography, the global radiotherapy market is segmented into 5 geographical
Radiation therapy, or radiotherapy, is the medical use of radioactive particles to kill and/or control the growth of malignant (cancerous) cells.
Head and neck patients who undergo surgery first are more likely to complete radiation therapy, according to Seattle-based researchers. Megan Dann Fesinmeyer, PhD, MPH, and colleagues noted that radiation dose and treatment duration correlated with tumor control and survival, but that breaks in radiotherapy have been associated with inferior tumor control. 1
With each advancement in radiotherapy treatment, from IMRT to IGRT to DART, quality assurance double checks even the most precise technologies for accuracy.
As Radiotherapy is a localised treatment, the side effects depend on the area of treatment and are individual. Professor Chan will go through any possible side effects with you before you start treatment and the Radiographers will be happy to discuss this with you and provide advice and support, together with an individual care plan. By using the latest technology and techniques, side effects of radiotherapy are minimised.. ...
Ninety-three cancer patients about to undergo radiotherapy were studied. These patients were affected by cancer of the head and neck, breast cancer, and abdominopelvic cancer. They were randomly distributed into control and experimental groups. The patients from the control group were allowed to eat …
Professor Jayant Vaidya (UCL General Surgery) has helped develop a new form of radiotherapy which can be given to breast cancer patients during surgery. Read: Times (£). ...
Clinical trial for Cancer of the Cervix , Clinical and Experimental Studies to Improve Radiotherapy Outcome in AIDS Cancer Patients
Humanmade peptides that directly disrupt the inner workings of a gene significantly reduce metastasis in a mouse model of breast cancer, scientists says.
jeanff, I know what you mean. I know I should feel grateful and that radiotherapy is nothing like as bad as chemotherapy. But laying naked - 648327
Statistics indicate that 1 in 8 women will be diagnosed with breast cancer and up to 90% of those being treated with radiotherapy will develop skin...
The present study presents a case of peritoneal malignant mesothelioma (PMM) following radiation therapy for cervical cancer. A 34‑year‑old Japanese woman, without asbestos exposure, was referred to the Department of Gynecologic Oncology, Saitama Medical University International Medical Center due to a cervical mass, and was diagnosed with cervical squamous cell carcinoma (SCC). The serum levels of tumor markers, including SCC antigen and cancer antigen 125 (CA125) were 229.0 ng/ml and 54.4 U/ml, respectively. The patient underwent concurrent chemoradiotherapy (CCRT), and a complete response was achieved. After 54 months, ascites was found at the rectouterine pouch, but peritoneal cytology suggested reactive mesothelial cell. After 62 months of CCRT, magnetic resonance imaging revealed masses in both the salpinges. The serum levels of SCC and CA125 were 0.9 ng/ml and 506.1 U/ml, respectively. Following this, left salpingectomy and peritoneal biopsy were performed laparoscopically. Histologic ...
N52.35 is a billable code used to specify a medical diagnosis of erectile dysfunction following radiation therapy. Code valid for the year 2020
This study will evaluate ribociclib following radiation therapy in children with newly diagnosed non-biopsied diffuse pontine gliomas (DIPG) and RB+ biopsied
TY - JOUR. T1 - Smoking effect on secondary bladder cancer after external beam radiotherapy for prostate cancer. AU - Shiota, Masaki. AU - Yokomizo, Akira. AU - Takeuchi, Ario. AU - Inokuchi, Junichi. AU - Tatsugami, Katsunori. AU - Ohga, Saiji. AU - Sasaki, Tomonari. AU - Nakamura, Katsumasa. AU - Honda, Hiroshi. AU - Eto, Masatoshi. PY - 2016/10/1. Y1 - 2016/10/1. N2 - Objective: Although it is well known that radiotherapy for prostate cancer increases comorbid rate of secondary bladder cancer, the effect of aging and smoking with radiotherapy on incidence rate of secondary bladder cancer remains unknown. Then, this study investigated the combinational effect of external beam radiotherapy for prostate cancer and aging or smoking on comorbid rate of secondary bladder cancer.Methods: This study included 754 Japanese patients with prostate cancer treated with radiotherapy (n = 319) and radical prostatectomy (n = 435) from 2000 through 2013. The relationship between therapeutic modality for ...
Over the course of its 100-year history, the centre for radiation oncology and tumour research has become one of the worlds largest and most modern facilities for radiooncology and radiotherapy. Radiation oncology is one of the three main pillars of cancer treatment together with surgery and chemotherapy.. More than 3,500 people are treated at the centre every year by specialist doctors and nurses, on both an inpatient and outpatient basis. All modern radiotherapy procedures for the treatment of tumours are offered at Heidelberg University Hospital. The department currently has eight radiotherapy systems including two tomotherapy units (which surround the patient like a CT scan), plus a facility for intraoperative radiotherapy in the departments of surgery and gynaecology. In addition, we offer the complete spectrum of brachytherapy, in which a localised radiation source is positioned near the tumour.. The Heidelberg Ion Therapy Centre (HIT), the only centre of its kind in Europe, represents a ...
Cardiovascular diseases following radiotherapy are major secondary late effects raising questions among the scientific community, especially regarding the dose-effect relationship and confounding risk factors (chemotherapy, cholesterolemia, age at treatment, blood pressure,…). Post-radiation coronary diseases are one of the main causes of cardiac morbidity. Some approximations are made when coronary doses due to radiotherapy are estimated, especially regarding the morphology. For retrospective studies with old medical records, only radiographs are usually available with sometimes some contours made with a simulator. For recent medical records, CT scans displaying the anatomy in 3D are used for radiotherapy simulation but do not allow the coronary artery visualization due to low resolution and contrast. Currently, coronary doses are barely assessed in clinical practice, and when it is done, anatomical prior knowledge is generally used. This thesis proposes an original approach based on hybrid ...
Purpose: Radiotherapy has reduced local recurrence of rectal cancers, but the result is not satisfactory. Further biologic factors are needed to identify patients for more effective radiotherapy. Our aims were to investigate the relationship of cyclooxygenase-2 (Cox-2) expression to radiotherapy, and clinicopathologic/biologic variables in rectal cancers with or without radiotherapy. Methods and Materials: Cox-2 expression was immunohistochemically examined in distal normal mucosa (n = 28), in adjacent normal mucosa (n = 107), in primary cancer (n = 138), lymph node metastasis (n = 30), and biopsy (n = 85). The patients participated in a rectal cancer trial of preoperative radiotherapy. Results: Cox-2 expression was increased in primary tumor compared with normal mucosa (p < 0.0001), but there was no significant change between primary tumor and metastasis. Cox-2 positivity was or tended to be related to more p53 and Ki-67 expression, and less apoptosis (p ≤ 0.05). In Cox-2-negative cases of ...
January 31, 2011 - An oncology systems provider has launched The Year of Radiotherapy, an initiative to raise awareness of radiotherapy as a cost-effective, cutting-edge treatment that can help cure cancer. Oncology Systems Limited (OSL) launched the program in response to data from Cancer Research UK.. According to figures published by Cancer Research UK, only one in 10 people know that radiotherapy helps cure 40 percent of cancer patients. A report from the national charity estimates that only 38 percent of cancer patients in England are getting radiotherapy, although research shows that up to 50 percent might benefit. We need to dispel the myths about radiotherapy and associated side effects and make people more aware of the benefits of the latest treatments, said Julie Mead, clinical director of OSL. But we also need to make sure that these treatments are available across the country. The U.K. lags behind America and Europe in introducing the new, more targeted radiotherapy technology ...
This technology provides a method for monitoring cellular death in radiotherapy patients using low-frequency ultrasound. It combines conventional frequency (5-10 MHz) ultrasound with new software to detect responses to radiotherapy in breast cancer tissues.. ...
Request for buying: Global Radiotherapy Market - Industry Trends and Forecast to 2024. Table of Contents:. 1. INTRODUCTION. 1.1. OVERVIEW OF THE GLOBAL RADIOTHERAPY MARKET. 1.2. MARKET SEGMENTATION & COVERAGE. 1.2.1. CURRENCY AND PRICING. 1.2.2. LIMITATION. 1.2.3. STAKEHOLDERS. 2. RESEARCH METHODOLOGY. 2.1. KEY TAKEAWAYS. 2.2. ARRIVING AT THE GLOBAL RADIOTHERAPY MARKET SIZE. 2.2.1. MARKET CRACKDOWN APPROACH. 2.2.2. COMPANY REVENUE AND MARKET SHARE ANALYSIS. 2.2.3. DATA TRIANGULATION. 2.2.4. KEY DATA POINTS FROM PRIMARY SOURCES. 2.2.5. PRODUCT PIPELINE ANALYSIS. 2.2.6. PORTERS FIVE FORCES MATRIX. 2.3. GLOBAL RADIOTHERAPY MARKET: RESEARCH SNAPSHOT. 2.4. ASSUMPTIONS. 3. MARKET OVERVIEW. 4. EXECUTIVE SUMMARY. 4.1. OVERVIEW. 4.2. GLOBAL RADIOTHERAPY MARKET: KEY PRIMARY INSIGHTS. 4.3. MARKET OVERVIEW. 4.3.1. DRIVERS. 4.3.2. RESTRAINTS. 4.3.3. OPPURTUNITIES. 4.3.4. THREATS. 4.4. KEY MARKET TRENDS AND UPCOMING TECHNOLOGIES. 5. GLOBAL RADIOTHERAPY MARKET, BY THERAPY TYPE. 5.1. OVERVIEW. 5.2. BEAM ...
Request for buying: Global Radiotherapy Market - Industry Trends and Forecast to 2024. Table of Contents:. 1. INTRODUCTION. 1.1. OVERVIEW OF THE GLOBAL RADIOTHERAPY MARKET. 1.2. MARKET SEGMENTATION & COVERAGE. 1.2.1. CURRENCY AND PRICING. 1.2.2. LIMITATION. 1.2.3. STAKEHOLDERS. 2. RESEARCH METHODOLOGY. 2.1. KEY TAKEAWAYS. 2.2. ARRIVING AT THE GLOBAL RADIOTHERAPY MARKET SIZE. 2.2.1. MARKET CRACKDOWN APPROACH. 2.2.2. COMPANY REVENUE AND MARKET SHARE ANALYSIS. 2.2.3. DATA TRIANGULATION. 2.2.4. KEY DATA POINTS FROM PRIMARY SOURCES. 2.2.5. PRODUCT PIPELINE ANALYSIS. 2.2.6. PORTERS FIVE FORCES MATRIX. 2.3. GLOBAL RADIOTHERAPY MARKET: RESEARCH SNAPSHOT. 2.4. ASSUMPTIONS. 3. MARKET OVERVIEW. 4. EXECUTIVE SUMMARY. 4.1. OVERVIEW. 4.2. GLOBAL RADIOTHERAPY MARKET: KEY PRIMARY INSIGHTS. 4.3. MARKET OVERVIEW. 4.3.1. DRIVERS. 4.3.2. RESTRAINTS. 4.3.3. OPPURTUNITIES. 4.3.4. THREATS. 4.4. KEY MARKET TRENDS AND UPCOMING TECHNOLOGIES. 5. GLOBAL RADIOTHERAPY MARKET, BY THERAPY TYPE. 5.1. OVERVIEW. 5.2. BEAM ...
Directory of patents related to Radiotherapy Apparatus (367 patents): Radiotherapy apparatus monitoring therapeutic field in real-time during treatment; Radiotherapy apparatus; Radiotherapy apparatus with independent rotation mechanisms; Radiotherapy system; Radiotherapy apparatus equipped with an articulable gantry for positioning an imaging unit
To assess by MR Imaging the lesions induced by WST09-mediated photodynamic therapy (PDT) in patients with recurrent or persistent localized prostate can
Late bowel effects of pelvic radiotherapy are usually managed or treated successfully. Talk to your doctor if you notice any symptoms.
While x-rays can be teratogenic in humans, the consequences of in utero exposure to radiotherapy are unclear in terms of dose and duration. Many of the data on the effects of exposure to ionizing radiation during pregnancy have arisen from studies on survivors of the atomic bombs used in World War II. Exposure to high doses of ionizing radiation has been associated with an increased risk of fetal malformations, mental retardation, growth retardation, and, in particular, small head circumference.1 4 However, only a few cases have been reported of pregnant mothers treated for cancer with radiotherapy applied to the upper body. Although some of these cases have reported normal outcomes, the offspring follow-up was too short to draw ultimate conclusions.. To highlight the complexities involved, we will present the case of the woman introduced in the Question. She received radiation for 4 weeks during the first trimester of pregnancy and decided to continue the pregnancy to term, as no fetal ...
We have around 2300 new referrals to the service each year, and an annual workload of around 33,500 fractions (attendances / treatments). Meaning on average, our department treats 120-145 patients each day on our four linear accelerators.. Working closely with the Hope Clinical Trials team, we are able to offer our patients the opportunity to participate in national and international clinical trials. We are also very proud to be the host for the East Midlands Operational Delivery Network, which is being developed to ensure that all patients across the East Midlands have equal access to modern radiotherapy treatments.. We understand that support throughout and after treatment is crucial for our patients. To help us provide this care we have strong links with the Macmillan Information and Support Centre which has a variety of support services and information that you might find helpful. You may also be interested in the HOPE course. Click here for further information.. What is radiotherapy? For ...
Over the course of its 100-year history, the centre for radiation oncology and tumour research has become one of the worlds largest and most modern facilities for radiooncology and radiotherapy. Radiation oncology is one of the three main pillars of cancer treatment together with surgery and chemotherapy.. More than 3,500 people are treated at the centre every year by specialist doctors and nurses, on both an inpatient and outpatient basis. All modern radiotherapy procedures for the treatment of tumours are offered at Heidelberg University Hospital. The department currently has eight radiotherapy systems including two tomotherapy units (which surround the patient like a CT scan), plus a facility for intraoperative radiotherapy in the departments of surgery and gynaecology. In addition, we offer the complete spectrum of brachytherapy, in which a localised radiation source is positioned near the tumour.. The Heidelberg Ion Therapy Centre (HIT), the only centre of its kind in Europe, represents a ...
Aims and Methods To add radiotherapy to SEMS and examine the impact on: i) duration of improvement of swallow; ii) quality of life; iii) survival. A pragmatic, randomised controlled trial of external beam radiotherapy plus SEMS versus SEMS alone in 396 patients with oesophageal cancer. Radiotherapy will be given as an outpatient either as five treatments over one week, or ten treatments over two weeks. Questionnaires assessing quality of life and cost effectiveness will be completed at weeks two, four, eight and twelve and then monthly for up to one year. Semi-structured interviews will be held with: i) trial participants to explore their experiences while on the trial; ii) patients who decide not to take part in the trial to explore reasons for non-consent.. ...
r.lost cancer patients may need external beam radiotherapy at certain times. Sufficient exposure of malignant cells and better avoidance of surrounding healthy tissues are necessary in order to minimise damage to non-cancerous regions. .Therefore, accurate patient positioning and proper radiation directions as well as dose distributions are crucial. A vital part of external beam radiotherapy is the geometric verification of treatment delivery. This thesis extensively studied three-dimensional (3D) to two-dimensional (2D) image registration methods. The author has proposed two novel methods to register computerised tomography (CT) based volume image data acquired for treatment planning with orthogonal planar images acquired at treatment simulation, which are able to recover the transformation errors in full six degrees of freedom (three translations and three rotations). The first proposed method is a novel feature-based method. It is based on automatic or semi-automatic extraction of object ...
Radiotherapy can be used to cure or control cancer in the pelvic area. This type of treatment is called pelvic radiotherapy and it is used to treat a number of different cancers.
Radiotherapy is the use of radiation to treat conditions such as cancer. The most common technique exposes tumors to high energy photons (x-rays) and/or electrons while sparing normal tissues. Other uses are to prepare a patient for organ transplantation by suppressing immune response and to calm muscle twitches. The therapy can be delivered from the outside (external beam radiotherapy), by radioactive implants placed in the body (brachytherapy), or during surgery (interoperative). Other types of radiotherapy such as proton therapy and neutron therapy -- available at very limited centers -- have their own distinct advantages and disadvantages.
A combination of a Virtalis ActiveWall and Virtual Environment Radiotherapy Training (VERT) software is enabling radiotherapy treatments to be taught using VR technology, completely eliminating both time pressure and danger to patients.. Already in use at leading teaching hospitals across the world, most especially in the UK, the latest institution to take delivery of a VERT system is The University of Applied Sciences, Vienna.. The life-like stereoscopic VR software immerses the student into a typical treatment room at a 1:1 scale, featuring a virtual patient on a treatment table with the linear accelerator above. The student controls VERT using the same controller that is used for real linear accelerators, with the controller both able to move the both the virtual table and the linear accelerator in order to achieve the correct positioning of the patient. The radiotherapy beam is visible as a virtual light beam. CT-sectional images, organs and dose distribution in the body caused by the ...
From an etiology standpoint, the question in each case is whether the presentation is due to cardiotoxicity from cancer treatment or coronary artery disease (CAD) unrelated to prior cancer therapy. In the first case, the patient has a history of lung cancer with last chemotherapy and radiation 1.5 years ago. Although the exact regimen was not specified, conventional chemotherapy used in lung cancer treatment is unlikely related to angina based on the mechanisms and timing of last exposure.1 If the radiation therapy was left-sided, there is certainly concern for cardiotoxicity from radiation. The mean heart dose was not specified, however, delayed onset CAD related to radiation therapy might have played a role in plaque rupture. Although the incidence of ischemic events increases significantly much later, as most cases present at 5 years or later post-radiation exposure,2 it is plausible that exposure to therapeutic radiation might have increased the risk for a coronary event. Common risk factors ...
Radiotherap-e is a web-based e-learning resource produced in partnership with The Royal College of Radiologists, the Institute of Physics and Engineering in Medicine, the Society and College of Radiographers, and Health Education England e-Learning for Healthcare.. Radiotherap-e offers multi-professional learning resources for the trained workforce involved in the delivery of radiotherapy, including clinical oncologists, physicists, radiographers and dosimetrists.. The aim is to provide the knowledge base and practical skills training to support the implementation of advanced radiotherapy techniques in the UK.. Topics covered include image interpretation and target volume delineation, dosimetry planning and optimisation, quality assurance and patient care.. The sessions include a variety of media including text, images, animations, videos and assessments, as well as a number of customised tools which simulate everyday tasks in the radiotherapy process.. ...
TY - ABST. T1 - DAHANCA19. T2 - A randomized phase III study of primary (chemo-) radiotherapy and zalutumumab in head and neck carcinomas. AU - Eriksen, J. G.. AU - Maare, C.. AU - Johansen, J.. AU - Primdahl, H.. AU - Evensen, J. AU - Kristensen, C. A. AU - Andersen, Lisbeth Juhler. AU - Overgaard, J.. PY - 2014. Y1 - 2014. M3 - Conference abstract in journal. VL - 111. SP - 154. EP - 155. JO - Radiotherapy & Oncology. JF - Radiotherapy & Oncology. SN - 0167-8140. IS - Suppl. 1. M1 - OC-0372. ER - ...
In this study, we demonstrate that SABR-induced antitumor immunity is tumor antigen-specific and that combination SABR and anti-PD-1 therapy is not restricted to tumor histology or host genetic factors. We show that PD-1 restrains the immune-mediated abscopal effect induced by local radiotherapy in a preclinical model. PD-1 blockade or deficiency can synergize with radiotherapy to induce tumor-specific CD8+ T-cell immunity and result in a clinical response in the secondary tumors outside of the radiation field.. The demonstration of radiotherapy-induced T-cell priming within the tumor by the sensitization of the tumor stroma (13) or at tumor-draining lymph nodes via activation of antigen-presenting dendritic cells (14), as well as the accumulation of effector CD8+ T cells inside the tumor microenvironment (15), supports the hypothesis that radiotherapy can elicit and enhance both the priming and effector phases of antitumor T-cell response. Consequently, if sufficient effector CD8+ cytotoxic ...
Inclusion Criteria: I1. Male or Female patients ≥18 years of age or older. I2. Histologically or cytologically proven metastatic squamous cell carcinoma (from head and neck, oesophagus, lung, cervix, vagina, vulva or anus) with the following features: - Previously treated with at least one prior regimen (chemotherapy, signal transduction inhibitors or radiotherapy) - To be treated with radiotherapy at primary tumor site or metastatic site or menacing metastatic site. - The sites of metastases allowed are: soft tissue, peripheral lung, and liver. - Patients with brain and bone metastasis to be treated with radiotherapy are not allowed. Patients with asymptomatic brain metastasis can be included. - The total tumor volume to be irradiated must not exceed 400 cc. I3. At least one tumor lesion must be accessible to radiation therapy and at least another tumor site can be spared from radiation therapy (unirradiated site). I4. At least one unirradiated and one irradiated tumor site must be accessible ...
Immune checkpoint inhibitors are considered as a major advance in a variety of cancer diseases with dismal prognosis (1). Despite outstanding progress in melanoma and lung cancers, a majority of patients will nevertheless fail in achieving long-lasting responses. Associating radiotherapy with immunotherapy has shown synergistic effect and is now considered as a promising strategy to stretch both response and survival at bedside (2). However, combining radiotherapy and immunotherapy can be done following a variety of different modalities. Determining the exact scheduling of the radioimmunotherapy association is therefore critical, and standard empirical approaches (trial-and-error) will hardly meet the current requirements of fast-track approvals of novel therapies. In this respect, developing modeling and simulation tools able to describe biological and pharmacodynamics processes should help to better determine an optimal solution among numerous possibilities.. Radiotherapy is widely used in the ...
Objectives The clinical outcomes of patients treated with spatially fractionated GRID radiotherapy (SFGRT) for bulky tumors of the head and neck at a single institution were evaluated retrospectively. Endpoints of interest included tumor response, symptom improvement, treatment tolerance, and adverse events. Methods Institutional review board approval was obtained prior to study initiation. The institutional database was queried for patients with tumors of the head and neck treated with SFGRT between August 2007 and April 2015. Medical records of identified patients were reviewed for treatment details and clinical endpoints of interest. SFGRT was delivered in one fraction of 15 gray (Gy) or 20 Gy; 6 megavolt (MV) or 18 MV photon beams were passed through a multileaf collimator (MLC)-based or brass GRID template. All patients had a planned course of conventionally-fractionated external beam radiotherapy (EBRT) to begin on the day following SFGRT delivery. Results Twenty-one consecutive
S&L begin their 1967 paper with a cleverly formulated hypothetical example of an RCT of two approaches to treating a particular but unspecified cancer: radiotherapy alone versus radiotherapy preceded by 30 days of sensitizing chemotherapy. They argue that if the purpose of the trial is explanatory (purely to test the hypothesis that sensitizing chemotherapy improves the action of radiotherapy) then the radiotherapy in each arm of the trial should be given at the same time. This would mean that in the radiotherapy alone group, it would be delayed until day 31, to make it exactly comparable to the radiotherapy delivered post chemotherapy. This approach renders the two arms comparable in relation to the radiotherapy, the only difference being the presence or absence of chemotherapy. It thus tests directly the hypothesis that chemotherapeutic pre-sensitization increases the effect of follow-on radiotherapy.. If, however, the purpose of the trial is pragmatic, that is, simply to identify which ...
Global players operating in this market are Varian Medical Systems, Inc., CIVCO Medical Solutions, Elekta AB, Nanobiotix, Accuray Incorporated, Brainlab AG, Ion Beam Applications SA, C. R. Bard, Inc., IsoRay Medical, Inc., TRF, Nordion, Inc., RaySearch Laboratories AB, PRECISIS AG, Mevion Medical Systems, Inc., and Mitsubishi Electric Corporation among other companies.. To Browse Full Report and Pricing: Global Radiotherapy Market - Trends and Forecast to 2022. Table of Content:. 1 INTRODUCTION. 1.1. OVERVIEW OF THE RADIOTHERAPY MARKET. 1.2. MARKET SEGMENTATION & COVERAGE. 1.2.1. CURRENCY AND PRICING 1.2.2. LIMITATION. 2 RESEARCH METHODOLOGY. 2.1. KEY TAKEAWAYS. 2.2. ARRIVING AT THE RADIOTHERAPY MARKET SIZE. 2.2.1. MARKET CRACKDOWN APPROACH 2.2.2. COMPANY REVENUE AND MARKET SHARE ANALYSIS. 2.2.3. DATA TRIANGULATION. 2.2.4. KEY DATA POINTS FROM PRIMARY SOURCES. 2.2.5. KEY DATA POINTS FROM SECONDARY SOURCES. 2.2.6. PORTERS FIVE FORCES MATRIX. 2.2.7. PEST ANALYSIS. 2.2.8. EPIDEMIOLOGY FORECASTING ...
Non-surgical interventions for late rectal problems (proctopathy) of radiotherapy in people who have received radiotherapy to the pelvis: Cochrane systematic review answers are found in the Cochrane Abstracts powered by Unbound Medicine. Available for iPhone, iPad, Android, and Web.
Know the cost of Radiotherapy in Cairo. HEALGURU INDIA is associated with best Radiotherapy Hospital in Cairo and top surgeons in Cairo. Book your appointment now
General information about radiotherapy This information sheet is a general guide to radiotherapy. The treatment and side effects you have from radiotherapy will vary depending on which part of your body
The Calypso System, with its GPS for the Body technology, utilizes miniature implanted transponders (grain of rice size) to provide precise, continuous information on the location of the tumor during external beam radiation therapy. Any movement by the patient, including internal movement of the tumor, may cause the therapeutic radiation treatment to miss its intended target and hit adjacent healthy tissue. In contrast to ionizing tumor targeting methods which cannot track a target in real-time, the Calypso System provides real-time tumor position information, thereby allowing physicians to deliver radiation directly to the tumor while sparing surrounding healthy organs from radiation exposure. Currently the Calypso System is cleared by the U.S. Food & Drug Administration (FDA) for use in radiation therapy for the prostate and prostatic bed; however, the technology is designed for body-wide applications and studies are underway using it in other locations in the body ...
Purpose: To evaluate the feasibility of delivering experimental radiation therapy to tumors in the mouse pancreas. Imaging and treatment were performed using combined CT (computed tomography)/orthovoltage treatment with a rotating gantry. Methods and Materials: After intraperitoneal administration of radiopaque iodinated contrast, abdominal organ delineation was performed by x-ray CT. With this technique we delineated the pancreas and both orthotopic xenografts and genetically engineered disease. Computed tomographic imaging was validated by comparison with magnetic resonance imaging. Therapeutic radiation was delivered via a 1-cm diameter field. Selective x-ray radiation therapy of the noninvasively defined orthotopic mass was confirmed using γH2AX staining. Mice could tolerate a dose of 15 Gy when the field was centered on the pancreas tail, and treatment was delivered as a continuous 360° arc. This strategy was then used for radiation therapy planning for selective delivery of therapeutic ...
Radiation Oncology Department at Sir H. N. Reliance Foundation Hospital and Research Centre offers high precision radiotherapy treatments to all cancer survivors.
An Australian who used to dream in black and white began dreaming in vivid colour about cars, fish and former girlfriends while having cancer radiotherapy
M.D Radiotherapy stands for Doctor of Medicine in Radiotherapy. A radiotherapist is a specialist who deals with treatment of cancer patients. The treatment of cancer is a multimodality comprehensive treatment with surgical oncology, radiation oncology ...
|p|A prospective randomised multicentre trial compared pre-operative radiotherapy followed by surgery with surgery alone for rectal cancer | or = 12 cm from the anal verge. Of 468 patients (mean age 67 years, range 31-94, 273 males) who met the entry criteria, 228 were randomised to radiotherapy (3|/p| …
Early cancer of the vulva is usually managed solely by surgery and therefore has no impact on a womans chance of conceiving. If chemotherapy and/or radiotherapy are required, this may affect fertility in some circumstances. If you are premenopausal and feel concerned about how these treatments will affect your fertility, talk to your doctor. Radiotherapy can make sexual
Researchers in this study used state-of-the-art artificial intelligence to highlight which information might predict sensitivity to the side effects of prostate radiotherapy. In particular, specific genetic characteristics - SNPs (single nucleotide polymorphisms) - were predictive of a patient suffering rectal bleeding.. At the moment there is no way to adjust doses of radiotherapy according to how sensitive a patient might be to the side effects. This means that while some men are receiving too much and suffering side effects, some are given too little and this compromises the chances of successful treatment. Side effects include bowel, urinary and sexual dysfunction and can be difficult for patients to tolerate and can persist after treatment.. The researchers suggest that with further validation, this information could be used to create personalised treatment plans for prostate cancer patients. The technique could also be applied to many other types of cancer that are treated with ...
Everything you need to know about image guided radiotherapy (igrt). What is (image guided radiotherapy (igrt)) y en qué consiste?
Date: 22 August-27 September 1996 Location: San Jose, Costa Rica Type of event: radiotherapy accident Description:. An error in the calibration of a cobalt-60 radiotherapy unit in Costa Rica resulted in overdosages of about 60%. The equipment change that produced the error occurred on 22 August, with the first treatments administered on 26 August. Of 42 patients that died through 7 July 1997, 3 died probably as a direct result of radiation exposure and 4 more with radiation exposure a contributing cause. Another 22 died probably of their disease and not of radiation exposure. Of the surviving overexposed patients, 4 suffered catastrophic consequences, 16 more severe effects, 26 had lesser effects, and 22 had no effects. Some sources attribute 17 deaths to the misadministrations. Consequences: 7 fatalities, 81 injuries. References: ...
Most cancer treatments damage healthy cells as well as cancer cells; this is the main cause of side effects. Side effects vary depending on the treatment used and everyone reacts differently. Chemotherapy targets rapidly dividing cells, hence the lining of the mouth and digestive tract, the hair, skin and bone marrow are all affected. Radiotherapy damages normal cells in and around the treated area. Biological therapies may also cause side effects. Most side effects disappear within a few weeks of treatment finishing.. Leukaemia treatment often involves having several types of drug at the same time, possibly in combination with radiotherapy, so it can be difficult to know which treatment is causing what side effect. Side effects from high dose chemotherapy or total body irradiation (TBI) given in preparation for a stem cell transplant are more severe than those from standard chemotherapy or radiotherapy regimens.. Tiredness. Chemotherapy and radiotherapy can cause tiredness making people feel ...
Unsealed source radiotherapy (systemic radioisotope therapy)[edit]. Main article: Unsealed source radiotherapy ... stereotactic ablative body radiotherapy, or SABR - also known as SBRT, or stereotactic body radiotherapy) for subcranial ... Radiation therapy or radiotherapy, often abbreviated RT, RTx, or XRT, is therapy using ionizing radiation, generally as part of ... Intraoperative radiotherapy[edit]. Main article: Intraoperative radiation therapy. Intraoperative radiation therapy (IORT) is ...
Radiotherapy[edit]. The use of X-rays as a treatment is known as radiation therapy and is largely used for the management ( ... Thus, gamma-rays generated for medical and industrial uses, for example radiotherapy, in the ranges of 6-20 MeV, can in this ...
Unsealed source radiotherapy (systemic radioisotope therapy)[edit]. Main article: Unsealed source radiotherapy ... May 2019). "Risk of subsequent primary cancers after carbon ion radiotherapy, photon radiotherapy, or surgery for localised ... stereotactic ablative body radiotherapy, or SABR - also known as SBRT, or stereotactic body radiotherapy) for subcranial ... Radiation therapy or radiotherapy, often abbreviated RT, RTx, or XRT, is a therapy using ionizing radiation, generally as part ...
Radiotherapy[edit]. The role of radiotherapy as an auxiliary (adjuvant) treatment after potentially curative surgery has been ... Radiotherapy may form part of treatment to attempt to shrink a tumor to a resectable state, but its use on unresectable tumors ... Chemotherapy and, to a lesser extent, radiotherapy are likely to be offered to most people, whether or not surgery is possible ... radiotherapy, chemotherapy, palliative care, or a combination of these.[1] Treatment options are partly based on the cancer ...
Resistance to radiotherapy[edit]. Resistance to radiotherapy is also commonly observed. However, to date, comparisons of ... though it is unclear if the tumor returns to the pre-therapy proportion of cancer stem cells after therapy or if radiotherapy ... malignant tissue before and after radiotherapy have not been done to identify genetic and epigenetic changes selected by ...
Medical imaging of radioisotopes and external beam radiotherapy[edit]. Cherenkov light emission imaged from the chest wall of a ... either from internal sources such as injected radiopharmaceuticals or from external beam radiotherapy in oncology. ... patient undergoing whole breast irradiation, using 6 MeV beam from a linear accelerator in radiotherapy. ...
Being a printed plate, the accuracy of the test depends on using the proper lighting to illuminate the page. A "daylight" bulb illuminator is required to give the most accurate results, of around 6000-7000K temperature (ideal: 6500K, Color Rendering Index (CRI) ,90), and is required for military color vision screening policy. Fluorescent bulbs are many times used in school testing, but the color of fluorescent bulbs and their CRI can vary widely. Incandescent bulbs should not be used, as their low temperature (yellow-color) give highly inaccurate results, allowing some color vision deficient persons to pass. Proper testing technique is to give only three seconds per plate for an answer, and not allow coaching, touching or tracing of the numbers by the subject. The test is best given in random sequence, if possible, to reduce the effectiveness of prior memorization of the answers by subjects. Some pseudo-isochromatic plate books have the pages in binders, so the plates may be rearranged ...
Radiotherapy. *Plaque radiotherapy. This article about the eye is a stub. You can help Wikipedia by expanding it.. *v ...
Dr. William Cumming in 1846 at the Royal London Ophthalmic Hospital (later Moorfields Eye Hospital), of his pioneering work wrote "every eye could be made luminous if the axis from a source of illumination directed towards a person's eye and the line of vision of the observer were coincident".[2] Although some credit the invention of the ophthalmoscope to Charles Babbage in 1847, it was not until it was independently reinvented by Hermann von Helmholtz in 1851 that its usefulness was recognized - it was to revolutionize ophthalmology.[3] While training in France, Andreas Anagnostakis, MD, an ophthalmologist from Greece, came up with the idea of making the instrument hand-held by adding a concave mirror. Austin Barnett created a model for Anagnostakis, which he used in his practice and subsequently when presented at the first Ophthalmological Conference in Brussels in 1857, the instrument became very popular among ophthalmologists. In 1915, Francis A. Welch and William Noah Allyn invented the ...
The U.S. Federal Aviation Administration will consider applicants with PRK once they are fully healed and stabilized, provided there are no complications and all other visual standards are met. Pilots should be aware, however, that potential employers, such as commercial airlines and private companies, may have policies that consider refractive surgery a disqualifying condition. Also, civilians who wish to fly military aircraft should know that there are restrictions on those who have had corrective surgery. The Army now permits flight applicants who have undergone PRK or LASIK. Uncomplicated, successful corneal refractive surgery does not require a waiver and is noted as information only.[21] The Navy and Marines will routinely grant a waiver for pilots or student naval aviators, as well as naval flight officers, UAS operators and aircrew, to fly after PRK and LASIK, assuming preoperative refractive standards are met, no complications in the healing process were encountered, asymptomatic with ...
Endothelial keratoplasty (EK) has been introduced by Melles et al. in 1998. Today there are three forms of EK. Deep Lamellar Endothelial Keratoplasty (DLEK) in which the posterior part of the recipient cornea is replaced by donor tissue. Descemet's Stripping (Automated) Endothelial Keratoplasty (DSEK/DSAEK) in which the diseased Descemet's membrane is removed and replaced by a healthy donor posterior transplant. The transplant tissue can be prepared by a surgeon's hand or ordered already prepared for surgery. Ocular Systems was the first organization to deliver prepared grafts for surgery in 2005.[20] DSEK/DSAEK uses only a small incision that is either self-sealing or may be closed with a few sutures. The small incision offers several benefits over traditional methods of corneal transplant such as Penetrating Keratoplasty. Because the procedure is less invasive, DSAEK leaves the eye much stronger and less prone to injury than full-thickness transplants. New medical devices such as the EndoSaver ...
After completion of surgery, the patient is transferred to the post anesthesia care unit and closely monitored. When the patient is judged to have recovered from the anesthesia, he/she is either transferred to a surgical ward elsewhere in the hospital or discharged home. During the post-operative period, the patient's general function is assessed, the outcome of the procedure is assessed, and the surgical site is checked for signs of infection. There are several risk factors associated with postoperative complications, such as immune deficiency and obesity. Obesity has long been considered a risk factor for adverse post-surgical outcomes. It has been linked to many disorders such as obesity hypoventilation syndrome, atelectasis and pulmonary embolism, adverse cardiovascular effects, and wound healing complications.[11] If removable skin closures are used, they are removed after 7 to 10 days post-operatively, or after healing of the incision is well under way. It is not uncommon for surgical ...
Other identified triggers include local injury to the face, lips, eyes, or mouth; trauma; surgery; radiotherapy; and exposure ... implications for clinical management of herpes simplex virus recurrence during radiotherapy". Oral Surg Oral Med Oral Pathol ...
... (EOG) is a technique for measuring the corneo-retinal standing potential that exists between the front and the back of the human eye. The resulting signal is called the electrooculogram. Primary applications are in ophthalmological diagnosis and in recording eye movements. Unlike the electroretinogram, the EOG does not measure response to individual visual stimuli. To measure eye movement, pairs of electrodes are typically placed either above and below the eye or to the left and right of the eye. If the eye moves from center position toward one of the two electrodes, this electrode "sees" the positive side of the retina and the opposite electrode "sees" the negative side of the retina. Consequently, a potential difference occurs between the electrodes. Assuming that the resting potential is constant, the recorded potential is a measure of the eye's position. ...
An optokinetic drum -also called catford drum- is a rotating instrument to test vision in which individuals are seated facing the wall of the drum. The interior surface of the drum is normally striped; thus, as the drum rotates, the subject's eyes are subject to a moving visual field while the subject remains stationary, this phenomenon is called optokinetic Nystagmus. The speed of the drum and the duration of the test may be varied. Control groups are placed in a drum without stripes or rotation. After exposure to the rotating drum, subjects are surveyed to determine their susceptibility to motion sickness. A study in which the optokinetic drum was used to test the symptoms of the sopite syndrome showed increased mood changes in response to the visual cues, though these effects were compounded by other environmental factors such as boredom and lack of activity.[1] ...
... measures the electrical responses of various cell types in the retina, including the photoreceptors (rods and cones), inner retinal cells (bipolar and amacrine cells), and the ganglion cells. Electrodes (DTL silver/nylon fiber string) are usually placed on the surface of the cornea for Full Field/Global/Multifocal ERG's and brass/copper electrodes are placed on the skin near the eye for EOG type testing. During a recording, the patient's eyes are exposed to standardized stimuli and the resulting signal is displayed showing the time course of the signal's amplitude (voltage). Signals are very small, and typically are measured in microvolts or nanovolts. The ERG is composed of electrical potentials contributed by different cell types within the retina, and the stimulus conditions (flash or pattern stimulus, whether a background light is present, and the colors of the stimulus and background) can elicit stronger response from certain components. If a dim flash ERG is performed ...
Radiotherapy. Radiotherapy is an important treatment for central nervous system tumors and has been demonstrated to extend ... Concurrent cyclophosphamide and craniospinal radiotherapy for pediatric high-risk embryonal brain tumors. 10(J), Retrieved from ...
radiotherapy. radiotherapy accident in Zaragoza[25]. 11. ?. Zaragoza, Spain 1996. radiotherapy. radiotherapy accident in Costa ... radiotherapy. Therac-25 radiation overdose accidents. 3. 3. 1984. orphan source. radiation accident in Morocco[23]. 8. 3. ... Radiotherapy accidents[change , change source]. Year. Type. Accident. ARS fatalities. ARS survivors. Location ... radiotherapy. Instituto Oncologico Nacional accident[28][2]. 3 to 7. ?. Panama City, Panama ...
... is a growing specialty in wealthy countries and the major forms of human treatment such as surgery and radiotherapy may be ... "Radiotherapy". Patient UK. Archived from the original on 9 July 2017.. Last Checked: 23 December 2015 ... "The present and future management of malignant brain tumours: surgery, radiotherapy, chemotherapy". Journal of Neurology, ...
by radiation generally: radiation therapy (radiotherapy) *intraoperative radiation therapy. *by EMR particles: *particle ... the radiotherapy is neoadjuvant (chronologically first but not primary in the sense of the main event). Premedication is ... consider surgical excision of a tumor as the first-line therapy for a certain type and stage of cancer even though radiotherapy ...
"Radiotherapy and Oncology. 19 (2): 95-108. doi:10.1016/0167-8140(90)90123-E. ISSN 0167-8140.. ...
Radiotherapy is used when drug treatment is failing to control the pain of a growing tumor, such as in bone metastasis (most ... Radiotherapy. In: Sykes N, Bennett MI & Yuan C-S. Clinical pain management: Cancer pain. 2nd ed. London: Hodder Arnold; 2008. ...
Radiotherapy is used when drug treatment is failing to control the pain of a growing tumor, such as in bone metastasis (most ... However, radiotherapy, surgery and chemotherapy may produce painful conditions that persist long after treatment has ended. The ... doi:10.1007/978-0-387-87579-8. ISBN 978-0-387-87578-1. Hoskin PJ (2008). "Radiotherapy". In Sykes N, Bennett MI, Yuan CS (eds ... Potentially painful cancer treatments include: immunotherapy which may produce joint or muscle pain; radiotherapy, which can ...
... radiotherapy; and exposure to wind, ultraviolet light, or sunlight. The frequency and severity of recurrent outbreaks vary ... implications for clinical management of herpes simplex virus recurrence during radiotherapy". Oral Surg Oral Med Oral Pathol ...
... radiotherapy; or a combination of these modalities. Regardless of treatment type, 30 of the 36 cases of FA-DBCL for which there ...
... radiotherapy; general surgery; ear nose and throat surgery; ophthalmology; anaesthesia; intensive care pain management; ... Pediatric Surgery Pediatrics Pharmacy Physiotherapy Plastic and Re-Constructive Service Psychiatry Radiology Radiotherapy Renal ...
1980: Houston radiotherapy accident, 7 fatalities.[14][75]. *5 October 1982: Lost radiation source, Baku, Azerbaijan, USSR. 5 ... In the United Kingdom, it was revealed in a court case that in March 2002 a radiotherapy source was transported from Leeds to ... "Accidental Overexposure of Radiotherapy Patients in Bialystok" (PDF). International Atomic Energy Agency. February 2004. ... 1974-1976: Columbus radiotherapy accident, 10 fatalities, 88 injuries from cobalt-60 source.[14][75] ...
... is used for unsealed source radiotherapy in nuclear medicine to treat several conditions. It can also be detected by ...
Plaque radiotherapy (125I). *Selective internal radiation therapy / SIR-Spheres / TheraSphere (90Y) ...
a b Stereotactic body radiotherapy (SBRT) *^ Leksell, Lars (1949). "A stereotaxic apparatus for intracerebral surgery". Acta ... This is evidence that immunotherapy may be useful for treatment of radiation necrosis following stereotactic radiotherapy.[27] ... Like other forms of radiation therapy (also called radiotherapy), it is usually used to treat cancer. Radiosurgery was ... Expansion of stereotactic radiotherapy to extracranial lesions is increasing, and includes metastases, liver cancer, lung ...
This topic contains 41 study abstracts on Radiotherapy indicating it may negatively impact Breast Cancer, Radiation Induced ... Head and neck radiotherapy may result in radiation-induced changes in the central nervous system and head and neck.Sep 01, 1996 ... Women treated with radiotherapy for breast cancer experience an increased risk of heart disease as a result. Jul 11, 2011. ... Radiotherapy may result in the enrichment of highly malingant cancer stem cells in breast cancer patients.Jul 31, 2011. ...
Unsealed source radiotherapy (also known as unsealed source radionuclide therapy (RNT) or molecular radiotherapy) uses ... Buscombe, J.; Navalkissoor, S. (1 August 2012). "Molecular radiotherapy". Clinical Medicine. 12 (4): 381-386. doi:10.7861/ ... "Palliative Radiotherapy for Bone Metastases: An ASTRO Evidence-Based Guideline". International Journal of Radiation Oncology* ...
Hypofractionated radiotherapy versus conventionally fractionated radiotherapy for patients with intermediate-risk localised ... encoded search term (What is hypofractionated radiotherapy?) and What is hypofractionated radiotherapy? ... What is hypofractionated radiotherapy?. Updated: Nov 29, 2018 * Author: Isamettin Andrew Aral, MD, MS; Chief Editor: Edward ... Surgery Versus Radiotherapy for Clinically-localized Prostate Cancer: A Systematic Review and Meta-analysis. Eur Urol. 2015 Nov ...
Current radiotherapy.. Br Med J 1973; 1 doi: https://doi.org/10.1136/bmj.1.5852.505 (Published 03 March 1973) Cite this as: Br ...
Radiotherapys second setback.. BMJ 1989; 298 doi: https://doi.org/10.1136/bmj.298.6667.183 (Published 21 January 1989) Cite ...
Radiotherapy Modalities  Conventional External Beam Radiotherapy (EBRT)  Intensity-modulated radiation therapy (IMRT)  ... radiotherapy-pancreatic cancer by fondas vakalis 2584 views * Esophageal squamous Cancer-therapy-... by fondas vakalis 1211 ... radiotherapy of bone metastases,Vakalis * 1. Ακτινοθεραπεία Ξ. Βακάλης Ακτινοθεραπευτής Ογκολόγος Ιατρικού κέντρου Αθηνών ... Adjuvant Radiotherapy  Done after operative decompression  Patchell et al study  Wait 3 weeks for wound healing before ...
Radiotherapy plays a key role in treatment, often in combination with chemotherapy and surgery in... ... Palliative radiotherapy can also be used to relieve local symptoms like dysphagia or bleeding. Careful radiotherapy planning is ... Herskovic A, Martz K, al-Sarraf M et al (1992) Combined chemotherapy and radiotherapy compared with radiotherapy alone in ... Radiotherapy Esophageal adenocarcinoma Neoadjuvant Palliative Chemoradiotherapy This is a preview of subscription content, log ...
Radiotherapy is the use of radiation in medicine as part of treatment (as opposed to radiology, which is the use of radiation ... Two main divisions of radiotherapy are external radiotherapy and internal radiotherapy, the difference being that in external ... Radiotherapy is the use of radiation in medicine as part of treatment (as opposed to radiology, which is the use of radiation ... Radiotherapy is commonly used for the treatment of tumours, usually as an adjunct to surgery and/or chemotherapy. The most ...
Radiotherapy News and Research. RSS Radiation therapy (in North America), or radiotherapy (in the UK and Australia) also called ... A combination of reduced-dose radiotherapy using intensity-modulated radiotherapy (IMRT) combined with concurrent cisplatin met ... Five-day regimen of radiotherapy safe, effective for men with high-risk forms of prostate cancer A study led by researchers at ... Study shows how gut bacteria can dull the efficacy of radiotherapy A study led by Ludwig Chicago Co-director Ralph Weichselbaum ...
Biologisch-mathematisches Modell Cancer Krebs Optimization Radiotherapy Strahlentherapie imaging tumor growth Authors and ... Each presentation has as its goal some aspect of the improvement, or optimization, of radiotherapy. This book is a collection ... TABLE OF CONTENTS Chapter GENERAL INTRODUCTION 1. 1 Introduction 1 1. 2 History of Cancer and its Treatment by Radiotherapy 8 1 ... of current ideas concerned with the optimization of human cancer radiotherapy. It is hoped that readers will build on this ...
Latest advances in external beam radiotherapy for hepatocellulalar carcinoma. Presented at Liver Disease awareness week 2014 ... External Beam Radiotherapy for Hepatocellular carcinoma * 1. Latest advances in radiotherapy for hepatocellular carcinoma Liver ... 3. What are the forms of radiotherapy? External beam radiotherapy • Photon beam 3D conformal Intensity Modulated (IMRT) Arc ... 6. Radiotherapy is not what it used to be … 6 * 7. More recently… • Significant improvement in image guidance and conformal RT ...
Women who receive radiotherapy for childhood cancers have increased risk of their pregnancies resulting in stillbirth, BBC News ... This proportion of stillbirths or newborn deaths was equal in both radiotherapy and non-radiotherapy groups. It is not possible ... Secondly, radiotherapy to the sex organs of boys did not increase the risk of them later fathering a child who was stillborn or ... Women who receive radiotherapy for childhood cancers have increased risk of their pregnancies resulting in stillbirth, BBC News ...
... in an attempt to ensure proper target localization during the course of radiotherapy: Inter... more ... The term image-guided radiotherapy (IGRT) refers to the use of imaging techniques, including the following, ... encoded search term (What is image-guided radiotherapy (IGRT)?) and What is image-guided radiotherapy (IGRT)? What to Read Next ... Hypofractionated radiotherapy versus conventionally fractionated radiotherapy for patients with intermediate-risk localised ...
... Radiotherapy is a key treatment modality for the management of various types of cancer. ... Fractionated radiotherapy is the main stimulus for the induction of cell death and of Hsp70 release of p53 mutated glioblastoma ... Immunological aspects of radiotherapy Authors: Heike Scheithauer, Claus Belka, Kirsten Lauber and Udo S Gaipl ... Radiotherapy, administered in fractionated as well as ablative settings, is an essential treatment component for breast cancer ...
Radiotherapy for Cancer Patients with Rheumatoid Arthritis. There has also been some concern about the use of radiotherapy to ... Radiotherapy has been proposed as an alternative treatment option for advanced disease in patients that do not experience ... To date, the place of radiotherapy in the treatment of rheumatoid arthritis in not known. It is not routinely recommended as a ... The first scientific research supporting the value of radiotherapy in the treatment of rheumatoid arthritis arose early in the ...
My husband starts 8 weeks of radiotherapy in September, just wondered how this had affected anyone else, we are I suppose ... radiotherapy. My husband starts 8 weeks of radiotherapy in September, just wondered how this had affected anyone else, we are I ... My husband starts 8 weeks of radiotherapy in September, just wondered how this had affected anyone else, we are I suppose ... Yes he had radical prostatectomy in Feb and starts radiotherapy in Sept sorry (I normally hate abreviations myself!) HT for ...
Also included are the latest techniques developed in the field of radiotherapy. ... Drugs for Radiotherapy. Cyclizine. Cyclizine is a histamine H1 inhibitor prescribed for adults and children 6 years and above ... Radiotherapy, otherwise called as radiation therapy, X-ray radiation or irradiation is the medical use of ionizing radiation to ... Radiotherapy is mainly used to treat cancer patients. Some of the commonly used radioactive substances are Caesium-137, Cobalt- ...
Looks like you are currently in United States but have requested a page in the Mauritania site. Would you like to change to the Mauritania site?. ...
It provides the background and rationale for the inclusion of radiotherapy in todays combined-modality approach, including ... This book deals in detail with all aspects of the best practice in modern radiotherapy for Hodgkin lymphoma. ... Acute and long-term side effects of radiotherapy are analyzed, and the implications for modern radiotherapy approaches in ... This book deals in detail with all aspects of the best practice in modern radiotherapy for Hodgkin lymphoma. It provides the ...
... breast radiotherapy (RT) are now recognized as rare but relevant sequelae, which has prompted research on risk structure... ... Haviland JS, Owen JR, Dewar JA et al (2013) The UK Standardisation of Breast Radiotherapy (START) trials of radiotherapy ... Vaidya JS, Wenz F, Bulsara M et al (2014) Risk-adapted targeted intraoperative radiotherapy versus whole-breast radiotherapy ... Heart toxicity Breast cancer radiotherapy Breast cancer Mean heart dose LAD Kardiale Toxizität durch Strahlentherapie bei ...
... a pathway in cancer cells that controls the motion of their mitochondria could make them more yielding to radiotherapy. ... Cancer: Scientists reveal how to boost radiotherapy. Written by Catharine Paddock, Ph.D. on September 14, 2018. - Fact checked ... "Our findings may also lead to novel strategies to improve the efficacy of ROS-mediated cancer therapies, such as [radiotherapy ... One reason that radiotherapy - which uses ionizing radiation - can shrink or eliminate tumors is because it increases ...
Practical Radiotherapy: Physics and Equipment, 3rd Edition Pam Cherry, Angela M. Duxbury ...
This includes a full range of radiotherapy auditing services.. Accurate dosimetry is essential to maintain and improve ... thus improving the accuracy of radiotherapy doses received by patients. ... including a full range of radiotherapy auditing services. ... Radiotherapy dosimetry audits X-ray air kerma and absorbed dose ... radiotherapy and, ultimately, to improve cancer survival rates. We provide dosimetry traceable to in-house primary standards ...
Brain cancer patients who undergo radiotherapy may face a higher risk of accelerated mental decline in later life, new research ... Radiotherapy patients tended to be slower at processing information and also had poorer attention than people who had received ... Brain cancer patients who undergo radiotherapy may face a higher risk of accelerated mental decline in later life, new research ... More than half of patients who had undergone radiotherapy suffered from mental decline, compared with just 27 per cent of ...
... Guest Edited by Dr Kirsten Lauber.. Radiotherapy is a central element of multimodal ... Resistance to radiotherapy is frequently encountered in patients with glioblastoma multiforme. It is caused at least partially ... Hypoxia imaging with 18F-FAZA PET/CT predicts radiotherapy response in esophageal adenocarcinoma xenografts Esophageal cancer ... We aimed to predict radiotherapy (RT) response by ima... Authors: Elodie Melsens, Elly De Vlieghere, Benedicte Descamps, ...
D50 in medicine is the half-maximal dose: the dose that produces 50% of the maximum response. It may specifically refer to the radiation dose required to achieve a 50% tumor control probability. LD50, is the dose required to kill half the members of a tested population after a specified test duration. H Gregerson, S Lindkaer Jensen, F Moody (1996). Essentials of Experimental Surgery: Gastroenterology. p. 19-3. ISBN 3718654962.CS1 maint: uses authors parameter (link) Lawrence S. Chin, William F. Regine (2010). Principles and Practice of Stereotactic Radiosurgery. p. 636. ISBN 978-0387710709.CS1 maint: uses authors parameter (link) v t ...
Plaque radiotherapy is a type of radiation therapy used to treat eye tumors. A thin piece of metal (usually gold) with ... CS1 maint: discouraged parameter (link) Plaque radiotherapy entry in the public domain NCI Dictionary of Cancer Terms This ... Sagerman, Robert H.; Alberti, W. (2003-01-29). Radiotherapy of intraocular and orbital tumors. Springer. pp. 40-. ISBN 978-3- ...
Learn more about linear accelerators and positioning products designed for radiotherapy treatment techniques like IGRT, IMRT, ... Committed to Radiotherapy. At Elekta we are commited to advancing in the field of radiotherapy. Through established consortia, ... Radiotherapy. Elekta innovation is responsible for introducing most of the critical technological advances in radiation ... As increasing numbers of people require radiotherapy as an integral part of their cancer treatment, there is a need for ...
Among them, only one patient was declined for radiotherapy and underwent mastectomy without radiotherapy. In four cases the ... Radiotherapy for breast cancer and pacemaker].. [Article in French]. Menard J1, Campana F, Kirov KM, Bollet MA, Dendale R, ... Four patients were treated with conserving surgery followed by breast radiotherapy and two with mastectomy followed by chest ... From November 2008 to December 2009, more than 900 patients received radiotherapy for their breast cancer in our department ...
Our fax number may be used for academic matters only. Contact information for a physicians clinical practice should be obtained from the CPSA website or the Alberta Referral Directory. In accordance with privacy legislation, no identifiable health information should be sent to the Deans Office.. Email: [email protected] (Media Inquiries: [email protected]). ...
  • 17. Radiotherapy Modalities  Conventional External Beam Radiotherapy (EBRT)  Intensity-modulated radiation therapy (IMRT)  Stereotactic radiotherapy  Stereotactic radiosurgery  Radioisotopes Finn MA, Vrionis FD, Schmidt MH. (slideshare.net)
  • Latest advances in external beam radiotherapy for hepatocellulalar carcinoma. (slideshare.net)
  • Now that our new building has been finalized the department of Radiotherapy has available 11 Elekta linear accelerators for external beam radiotherapy. (umcutrecht.nl)
  • Examples are (i) the development of the MRI Linac (MRL) system for real time and on-line MRI guidance of external beam radiotherapy, (ii) the development of MRI guided brachytherapy, (iii) MRI based tumour characterization, delineation and treatment response assessment, (iv) the MRI guided high intensity focused ultrasound (HIFU) for tumour ablation and medicine deposition. (umcutrecht.nl)
  • The radiotherapy team plan your external beam radiotherapy before you start treatment. (cancerresearchuk.org)
  • External beam radiotherapy is one of the curative treatment options for localised prostate cancer. (nih.gov)
  • Finally, future developments will be described, including hypofractionation and dose individualisation, which have the potential to further improve the outcome of external beam radiotherapy for prostate cancer. (nih.gov)
  • For stage I disease, a total dose of 20 Gy is delivered in 10 fractions of external beam radiotherapy . (medscape.com)
  • Late anorectal toxicity influences quality of life after external beam radiotherapy (EBRT) for prostate cancer. (urotoday.com)
  • External Beam Radiotherapy Increases the Risk of Bladder Cancer When Compared with Radical Prostatectomy in Patients Affected by Prostate Cancer: A Population-based Analysis. (urotoday.com)
  • Long-term survival can be achieved in patients affected by localized prostate cancer (PCa) treated with either radical prostatectomy (RP) or external beam radiotherapy (EBRT). (urotoday.com)
  • Health-related quality of life in men with prostate cancer undergoing active surveillance versus radical prostatectomy, external-beam radiotherapy, prostate brachytherapy and reference population: a cross-sectional study. (urotoday.com)
  • The purpose of this study is to describe Health-Related Quality of Life (HRQoL) of localized prostate cancer patients in an Active Surveillance (AS) program, and to compare them with those undergoing radical prostatectomy (RP), external-beam radiotherapy (XRT) and brachytherapy (BT). (urotoday.com)
  • To summarize recent evidence concerning the use of moderately hypofractionated external beam radiotherapy, defined as 2.4-3.4 Gy per fraction, and ultrahypofractionated external beam radiotherapy (also known as stereotactic body radiotherapy [SBRT]), defined as at least 5 Gy per fraction, in men with localized prostate cancer. (urotoday.com)
  • Influence of localization of PSMA-positive oligo-metastases on efficacy of metastasis-directed external-beam radiotherapy-a multicenter retrospective study. (urotoday.com)
  • Two hundred and nineteen thousand new cases of prostate cancer have been projected in the Unites States for 2007, with external beam radiotherapy (EBRT) constituting the mainstay of local therapy for an increasing proportion of newly diagnosed patients. (clinicaltrials.gov)
  • Despite improvements in the delivery and reduction in associated toxicity of external beam radiotherapy, local persistence or recurrence of disease remains prevalent in 25-51% of patients. (clinicaltrials.gov)
  • External-beam radiotherapy has long been challenged by the simple fact that patients can (and do) move during the delivery of radiation. (routledge.com)
  • Between January 2008 and December 2012، 195 patients with locally advanced carcinoma cervix [International Federation of Gynecology and Obstetrics (FIGO) stage IIB-IIIB]، were treated with external beam radiotherapy (EBRT) to a dose of 45 Gy in 25 fractions along with concurrent chemotherapy (cisplatin 40 mg/m2)، followed by HDR brachytherapy EQD2 of 30 Gy. (magiran.com)
  • When it's performed on the body rather than the brain, this procedure is sometimes called stereotactic body radiotherapy (SBRT) or stereotactic ablative radiotherapy (SABR). (mayoclinic.org)
  • Body radiotherapy usually involves between one to five sessions. (mayoclinic.org)
  • For people who have early-stage cancer limited to the lung without involvement of lymph nodes, a specialized radiation treatment called stereotactic body radiotherapy (SBRT) may be an option. (mayoclinic.org)
  • Is Stereotactic Body Radiotherapy (SBRT) in lymph node oligometastatic patients feasible and effective? (mendeley.com)
  • Objectives: To review the available data about stereotactic body-radiotherapy (SBRT) for oligometastatic lymph node cancer recurrence. (mendeley.com)
  • During the 2017 Radiosurgery Society Scientific Meeting held November 2 - 4, 2017, in Las Vegas, NV, the Radiosurgery Society (RSS) announced that RSSearch® Patient Registry surpassed 20,000 patients treated with stereotactic radiosurgery (SRS)/stereotactic body radiotherapy (SBRT) and entered into the multi-institutional registry. (prweb.com)
  • Originally formed in 2002 and becoming (501c6) in 2008, the Radiosurgery Society today ( http://www.therss.org ) represents approximately 600 members who perform stereotactic body radiotherapy and radiosurgery in hospitals and freestanding centers throughout the world. (prweb.com)
  • A wide spectrum of advanced radiation treatments are available with TrueBeam, including intensity modulated radiation therapy (IMRT), stereotactic body radiotherapy (SBRT) and volumetric modulated arc therapy (VMAT). (atlantichealth.org)
  • P. Hoskin and C. Coyle (ed), Radiotherapy in Practice: Brachytherapy, Oxford University Press, (2005). (edu.au)
  • The research in the field of clinical physics focuses on hyperthermia (H. Crezee), brachytherapy (B.R. Pieters) and adaptive radiotherapy (A.Bel). (amc.nl)
  • Planning for internal radiotherapy is different from planning for external treatment and will depend on whether you have brachytherapy (see below), radionuclide therapy or selective internal radiation therapy . (cancervic.org.au)
  • The company is the world's leading manufacturer of medical devices and software for treating cancer and other medical conditions with radiotherapy, radiosurgery, proton therapy and brachytherapy. (varian.com)
  • The Hirslanden Institute of Radiotherapy is already one of the largest institutes of radiotherapy in Switzerland with four linear accelerators, a Cyberknife and devices for brachytherapy and intraoperative radiotherapy. (hirslanden.ch)
  • Phase III trial comparing whole-pelvic versus prostate-only radiotherapy and neoadjuvant versus adjuvant combined androgen suppression: Radiation Therapy Oncology Group 9413. (medscape.com)
  • Radiation therapy (in North America), or radiotherapy (in the UK and Australia) also called radiation oncology, and sometimes abbreviated to XRT, is the medical use of ionizing radiation as part of cancer treatment to control malignant cells (not to be confused with radiology, the use of radiation in medical imaging and diagnosis). (news-medical.net)
  • Researchers at the Department of Radiation Oncology, La Milagrosa Hospital, GenesisCare, Madrid, Spain, showed the potential benefit of treating COVID-19 pneumonia with ultra-low doses of radiotherapy. (news-medical.net)
  • A combination of reduced-dose radiotherapy using intensity-modulated radiotherapy (IMRT) combined with concurrent cisplatin met the threshold for disease control and quality of life compared to the standard of care for good-risk patients with HPV-associated oropharyngeal squamous cell carcinoma on the NRG Oncology clinical trial NRG-HN002. (news-medical.net)
  • This series from Radiation Oncology aims to introduce our readers to recent developments in preclinical radiotherapy, to present achievements as well as future challenges, and to discuss limitations. (biomedcentral.com)
  • Journal of the European Society for Radiotherapy and Oncology and affiliated to the Canadian Association of Radiation Oncology . (elsevier.com)
  • ESTRO members can access Radiotherapy and Oncology online via the members-only section of the ESTRO website: please go to http://www.estro.org and follow the links. (elsevier.com)
  • Radiotherapy and Oncology publishes papers describing original research as well as review articles. (elsevier.com)
  • Basic Radiotherapy Physics and Biology is a valuable reference for students and prospective students in every discipline of radiation oncology. (springer.com)
  • Radiotherapy oncology is the medical specialty concerned with prescribing radiation, either with the intent to cure, for adjuvant therapy, as palliative treatment or as therapeutic treatment. (amc.nl)
  • Lora Ioannou and Stefani Stefanou, Radiotherapy Medical Physicists from Bank of Cyprus Oncology Centre in Nicosia, have relied on the IAEA for dosimetry audits of the photon beams in their hospital for many years. (iaea.org)
  • They published their findings in Radiotherapy and Oncology this month. (eurekalert.org)
  • Going without antiperspirants entirely for a 3-6 week course of radiotherapy can have a negative impact on a patient's quality-of-life," said the study's lead author Brian C. Baumann, MD, who recently completed his residency in Radiation Oncology at Penn and is a member of Penn's Leonard Davis Institute of Health Economics. (eurekalert.org)
  • Varian introduced the new VitalBeam platform last Saturday, as part of at a special unveiling at the annual ESTRO (European Society for Radiotherapy and Oncology) meeting taking place in Barcelona through April 28. (varian.com)
  • The company supplies informatics software for managing comprehensive cancer clinics, radiotherapy centers and medical oncology practices. (varian.com)
  • be committed and enthusiastic about a career in radiotherapy and oncology and demonstrate a good understanding of the role. (prospects.ac.uk)
  • A visit to a radiotherapy and oncology department is essential to develop this understanding. (prospects.ac.uk)
  • This course provides non-radiotherapy graduates with a postgraduate qualification in radiotherapy and oncology. (prospects.ac.uk)
  • What is image-guided radiotherapy (IGRT)? (medscape.com)
  • van Herk, M. Different styles of image-guided radiotherapy. (nature.com)
  • PALO ALTO, Calif., April 27, 2015 /PRNewswire/ -- Varian Medical Systems (NYSE:VAR) last week unveiled a radiotherapy platform designed to offer clinics an affordable option for implementing advanced image-guided radiotherapy. (varian.com)
  • Radiotherapy plays a key role in treatment, often in combination with chemotherapy and surgery in multi-modalities management. (springer.com)
  • Herskovic A, Martz K, al-Sarraf M et al (1992) Combined chemotherapy and radiotherapy compared with radiotherapy alone in patients with cancer of the esophagus. (springer.com)
  • Radiotherapy is commonly used for the treatment of tumours, usually as an adjunct to surgery and/or chemotherapy . (everything2.com)
  • The researchers used medical records to determine the chemotherapy (drug therapy) given to treat the cancer and doses of radiotherapy given to different sites of the body. (www.nhs.uk)
  • Most people in the sample had received some radiotherapy, either alone or in combination with chemotherapy (61% of women and 62% of men). (www.nhs.uk)
  • There is opinion saying Radiotherapy and Chemotherapy treatment are not actually killing the cancer cells but the cells are kept [or maybe deactivated] for a period of time. (medindia.net)
  • Unlike some other cancer fighting technologies such as chemotherapy, radiotherapy requires special equipment and not all veterinarian offices are capable of performing the procedure. (ehow.co.uk)
  • Radiotherapy can cause similar side effects to those caused by chemotherapy including nausea and vomiting, hair loss and fatigue. (leukaemia.org.au)
  • Radiotherapy is preferred for primary therapy in stage IIA, while chemotherapy is preferred in stage IIB and in both good-risk and intermediate-risk stage IIC and III disease. (medscape.com)
  • For stage IIB disease, chemotherapy is preferred, but radiotherapy may be indicated in select cases of non-bulky disease. (medscape.com)
  • While a course of radiotherapy in addition to chemotherapy and a cancer operation reduced the number of local disease recurrences, it did not affect distant recurrences or survival. (medindia.net)
  • The researchers assessed the patterns of disease recurrence in three groups of patients: those who underwent a surgical procedure alone, those who had adjuvant chemotherapy, and those who had radiotherapy in addition to chemotherapy. (medindia.net)
  • Preliminary results of a randomized radiotherapy dose-escalation study comparing 70 Gy with 78 Gy for prostate cancer. (medscape.com)
  • Careful radiotherapy planning is required to ensure adequate dose to target volumes without overdose to normal organs. (springer.com)
  • Kong FM, Ritter T, Quint DL et al (2011) Consideration of dose limits for organs at risk of thoracic radiotherapy: atlas for lung, proximal bronchial tree, esophagus, spinal cord, ribs and brachial plexus. (springer.com)
  • Could ultra-low dose radiotherapy treat COVID-19-related pneumonia? (news-medical.net)
  • Writing in the Lancet Neurology, the researchers concluded: 'The current results indicate that radiotherapy is associated with long-term cognitive deterioration, regardless of fraction dose. (netdoctor.co.uk)
  • As such, the implementation of new imaging modalities, the improvement of treatment planning algorithms, the development of image-guidance techniques for dose administration, and the advent of new irradiation qualities have transformed radiotherapy into a versatile tool of high precision radiosurgery. (biomedcentral.com)
  • Radiation-induced pneumonitis and fibrosis represent severe and dose-limiting side effects in the radiotherapy of thorax-associated neoplasms leading to decreased quality of life or - as a consequence of treat. (biomedcentral.com)
  • The major topic areas include: Introduction and a Radiobiological Basis for Radiotherapy, Radiation Dosimetry, Dose Calibration Protocols, Equipment in Radiotherapy, Radiotherapy Prescription and Treatment Planning, Dose Calculation, Radiotherapy Treatment Techniques, Advanced Topics in Radiotherapy. (edu.au)
  • This means working out the dose of radiotherapy you need and exactly where you need it. (cancerresearchuk.org)
  • A portable orthovoltage radiotherapy system is described that is configured to deliver a therapeutic dose of radiation to a target structure in a patient. (google.es)
  • Your team use the planning appointment to work out the dose of radiotherapy you need and exactly where you need it. (cancerresearchuk.org)
  • however, serious radioactive pneumonia is rare for the radiotherapy of neck lymphoma because the volume of the lungs affected by radiation dose was very small. (hindawi.com)
  • This article will describe recent advances in prostate radiotherapy, focussing on the results of randomised trials which have addressed the role of radiation dose escalation and of adjuvant hormone therapy. (nih.gov)
  • Before you start radiotherapy, the radiotherapist (doctor who specialises in treating people with radiotherapy) will carefully calculate the correct dose of radiation therapy for you. (leukaemia.org.au)
  • When you are having radiotherapy you usually lie on a table underneath the radiotherapy machine which delivers the planned dose of radiation. (leukaemia.org.au)
  • Quality assurance programmes for radiotherapy processes are established to guarantee that the dose delivered to the target inside a patient undergoing radiotherapy is correct. (iaea.org)
  • However, radiotherapy planning tools focus purely on dose, without taking into account the physical and biological responses of the treatment. (europa.eu)
  • Figure 1: Dose-response curves for radiotherapy. (nature.com)
  • Moran, J. M., Elshaikh, M. A. & Lawrence, T. S. Radiotherapy: what can be achieved by technical improvements in dose delivery? (nature.com)
  • Conventional or hypofractionated high dose intensity modulated radiotherapy in prostate cancer: Preliminary report on acute and late toxicity. (nature.com)
  • The radiotherapy dose is divided into a number of smaller doses (known as fractions) to reduce the risk of side effects. (newcastle-hospitals.org.uk)
  • Clinics can add RapidArc® radiotherapy for faster IMRT, higher dose delivery rates, an on-board kV X-ray system capable of cone-beam CT imaging, and a higher-resolution 120-leaf collimator. (varian.com)
  • Dose distribution evaluation in oncological radiotherapy treatments is an outstanding problem that requires sophisticated computing technologies to optimize the clinical results (i.e. increase the dose to the tumour and reduce the dose to the healthy tissues). (doaj.org)
  • Nowdays, dose calculation algorithms based on the Monte Carlo method are generally regarded as the most accurate tools for radiotherapy. (doaj.org)
  • The developed package (MedLinac2) allows to simulate in an adequate flexible way a linear accelerator for radiotherapy and to evaluate the dose distributions. (doaj.org)
  • 16. Indications of Radiotherapy As Primary Treatment 1. (slideshare.net)
  • Radiotherapy is the use of radiation in medicine as part of treatment (as opposed to radiology , which is the use of radiation in medical imaging and diagnosis ). (everything2.com)
  • Occasionally radiotherapy is used as part of palliative treatment , where cure is not possible and the aim is for symptomatic relief . (everything2.com)
  • Dartmouth's and Dartmouth-Hitchcock's Norris Cotton Cancer Center (NCCC) is the first cancer center in the world to install BeamSite Cherenkov imaging cameras in its radiotherapy treatment rooms. (news-medical.net)
  • A study led by Ludwig Chicago Co-director Ralph Weichselbaum and Yang-Xin Fu of the University of Texas Southwestern Medical Center has shown how bacteria in the gut can dull the efficacy of radiotherapy, a treatment received by about half of all cancer patients. (news-medical.net)
  • 2 History of Cancer and its Treatment by Radiotherapy 8 1. (springer.com)
  • Radiotherapy is a key treatment modality for the management of various types of cancer. (biomedcentral.com)
  • Radiotherapy, administered in fractionated as well as ablative settings, is an essential treatment component for breast cancer. (biomedcentral.com)
  • Radiotherapy has been proposed as an alternative treatment option for advanced disease in patients that do not experience significant improvement or are affected by adverse effects of other treatments. (news-medical.net)
  • The efficacy of radiotherapy as a treatment for rheumatoid arthritis is still being established, however, with scientific research showing varied results. (news-medical.net)
  • The first scientific research supporting the value of radiotherapy in the treatment of rheumatoid arthritis arose early in the twenty-first century, despite the therapy being used in patients in a clinical setting for several decades previously. (news-medical.net)
  • To date, the place of radiotherapy in the treatment of rheumatoid arthritis in not known. (news-medical.net)
  • Therefore, the benefits and risk of radiotherapy treatment for patients with rheumatoid arthritis should be considered for the appropriate treatment decisions to be made. (news-medical.net)
  • Radiotherapy planning using state-of-the-art imaging, target definition, planning software, and treatment equipment is expounded in detail. (springer.com)
  • Radiotherapy is a central element of multimodal cancer treatment, which has experienced tremendous advancements in the recent years and decades. (biomedcentral.com)
  • It is important to know that not all cancer tumours will respond positively to any one treatment and may require other types of treatments in combination with or instead of radiotherapy and that, in some cases, nothing will eliminate the cancer. (ehow.co.uk)
  • As increasing numbers of people require radiotherapy as an integral part of their cancer treatment, there is a need for treatment delivery systems that can deliver precise and accurate care quickly. (elekta.com)
  • The multidisciplinary work with position change of the pacemaker before radiotherapy and everyday monitoring permitted the safe treatment of our patients. (nih.gov)
  • Less invasive treatment with radiotherapy can be as effective as surgery in some patients with breast cancer, a study has shown. (netdoctor.co.uk)
  • radiotherapy refers to the use of ionizing radiation in the treatment of disease - mainly cancer . (encyclopedia.com)
  • In recent years radiologists involved in radiotherapy have expanded their activities to include the use of radioisotopes and also the combination of radiotherapy with a variety of chemotherapeutic drugs or with hormones in the treatment of cancer. (encyclopedia.com)
  • Gliomatosis cerebri: treatment results with radiotherapy alone. (nih.gov)
  • You might have other types of scans or x-rays to help your treatment team plan your radiotherapy. (cancerresearchuk.org)
  • Your treatment team can put all the scans together in a special computer to decide your radiotherapy plan. (cancerresearchuk.org)
  • Radiotherapy treatment area marks. (cancerresearchuk.org)
  • The treatment is given in the hospital radiotherapy department. (macmillan.org.uk)
  • Radiotherapy is still one of the effective means for treatment of malignant tumors up to now. (hindawi.com)
  • Radiotherapy is the medical use of ionizing radiation, generally as part of cancer treatment to control malignant cells. (amc.nl)
  • You may have internal radiotherapy as an inpatient or outpatient, depending on the type of treatment you have. (cancervic.org.au)
  • Planning and treatment procedures for internal radiotherapy may vary between hospitals. (cancervic.org.au)
  • There are no waiting lists for access to clinics or treatment in any of the public radiotherapy facilities. (hse.ie)
  • The nursing staff at the radiotherapy department will advise you on how to care for your skin while you are having treatment. (leukaemia.org.au)
  • According to the IAEA DIrectory of RAdiotherapy Centres (DIRAC), about half of radiotherapy treatment units installed globally since 2010 can produce clinical electron beams. (iaea.org)
  • Verifying the calibration of the treatment unit is the cornerstone of radiotherapy quality assurance, and external dosimetry audits have been widely recognized as an invaluable tool for quality control of the calibration and are mandatory in some countries. (iaea.org)
  • The overriding objective is to personalize radiotherapy treatment and medical imaging protocols by tailoring doses to each individual case. (cea.fr)
  • Abnormal dreams have not previously been associated with radiotherapy treatment of the head, but this may be due to lack of reporting, says McKay. (newscientist.com)
  • The man's tumour was cured by radiotherapy and he reverted to black-and-white dreaming a few days after finishing treatment. (newscientist.com)
  • UPMC's management of the Advanced Radiotherapy Center of Excellence at San Pietro Hospital in Rome, Italy, fulfills an unmet need for advanced radiotherapy treatment close to home. (upmc.com)
  • Radiotherapy is an established curative treatment method for prostate cancer. (urotoday.com)
  • On the patient side, 92 women responded who said they have received radiotherapy for breast cancer, 73 of whom (79 percent) say their healthcare providers advised them to avoid using deodorant for the duration of their treatment. (eurekalert.org)
  • For this study the radiation therapists used a daily 3D image of the tumour to adjust the patient's position under the radiotherapy machine, and if they discovered any change during the course of radiotherapy, doctors and physicists were able to adapt the radiation treatment. (eurekalert.org)
  • Comparisons: This study aims to compare the different mouth care regimes and determine the most effective treatment alternatives during radiotherapy. (clinicaltrials.gov)
  • The lens can withstand and precisely focus the high levels of radiation produced by synchrotron devices onto tumors during precision radiotherapy treatment. (photonics.com)
  • excellent discussion on medical imaging and computerized treatment optimization … good overview of developments in biological models and processes … good perspective on the role of proton therapy and source of the facilities … excellent background, guidelines, and extensive critical evaluations on the practicality of every item covered … an excellent update on advances in technology related to conformal radiotherapy. (routledge.com)
  • Adaptive Motion Compensation in Radiotherapy provides the first detailed treatment of online interventional techniques for motion compensation radiotherapy. (routledge.com)
  • From these chapters, readers will gain not only an understanding of the technical aspects and capabilities of motion adaptation but also practical clinical insights into planning and carrying out various types of motion-adaptive radiotherapy treatment. (routledge.com)
  • More than half of all cancer patients receive radiotherapy as a part of their treatment. (mdpi.com)
  • IORT requires specialized radiotherapy equipment, and there are several technologies available to provide IORT partial breast irradiation, which deliver treatment with either electrons or 50 kV X-rays. (frontiersin.org)
  • Curcumin pre-treatment could reduce the effect of radiation on the skin of patients receiving radiotherapy for the treatment of cancer. (greenmedinfo.com)
  • The multidisciplinary features (systemic treatment، endocrine therapy، and surgery)، patient profile (history of underlying diseases، age، and habits)، and irradiation-associated parameters are the factors affecting safe adjuvant radiotherapy. (magiran.com)
  • Implications for breast cancer treatment from increased autotaxin production in adipose tissue after radiotherapy. (eurekalert.org)
  • Understanding the impact of radiotherapy at the microscale will help improve treatment outcome and minimise side effects. (europa.eu)
  • All seven clinical health boards in Wales were asked how much they spent on radiotherapy in 2009-10 and 2010-11, how many patients were treated, whether they sent any patients outside Wales for such treatment, and if so how much that cost. (walesonline.co.uk)
  • Likewise it does not record how many patients were send for radiotherapy treatment or how much it cost. (walesonline.co.uk)
  • Ms Williams said: "Radiotherapy is vital to the treatment of cancer and it is of paramount importance that Welsh patients receive the latest and best treatment, but it is staggering that some of our health boards don't know how many people they are treating or how much they are spending on treatment. (walesonline.co.uk)
  • Cyberknife, which uses a laser to focus on cancer cells, is able to concentrate treatment into a handful of sessions instead of the 25 routinely required with radiotherapy. (walesonline.co.uk)
  • We are the North of England's regional centre for paediatric radiotherapy and one of a small number of centres in the country that offers specialist treatment for lung cancer called CHART (Continuous, Hyper-fractionated, Accelerated Radiotherapy for Treatment). (newcastle-hospitals.org.uk)
  • CHART is a form of treatment which gives you more concentrated sessions of radiotherapy, allowing you to be treated more quickly. (newcastle-hospitals.org.uk)
  • To help you get an idea of what to expect, we have outlined below one of the common journeys through radiotherapy treatment. (newcastle-hospitals.org.uk)
  • As part of the preparation for your treatment, you may need to go to the "mould room", where a piece of equipment will be made for you to wear during radiotherapy to keep you in the right position. (newcastle-hospitals.org.uk)
  • Before you have radiotherapy, your oncologist will have explained the benefits, risks and possible side effects of your treatment, and we will ask you to sign a consent form to say that you agree to go ahead with the treatment. (newcastle-hospitals.org.uk)
  • Some of our research projects investigate the methodology of treatment outcome evaluation, and the best use of palliative radiotherapy. (sunnybrook.ca)
  • It provides the background and rationale for the inclusion of radiotherapy in today's combined-modality approach, including special clinical situations such as Hodgkin lymphoma in children, in the pregnant patient, and in the elderly. (springer.com)
  • The department collaborates with a track clinical physics radiotherapy in the master's programme on Biomedical Image Sciences (BIS). (umcutrecht.nl)
  • Compromise position' image alignment to accommodate independent motion of multiple clinical target volumes during radiotherapy: A high risk prostate cancer example. (urotoday.com)
  • Of the eight patients who received brain radiotherapy, the clinical and radiologic follow-up findings improved in three patients, stabilized in three patients, and worsened in two patients. (nih.gov)
  • The doctor who plans your radiotherapy (clinical oncologist) or a specialist nurse will tell you what to expect. (macmillan.org.uk)
  • How multi-modality (combined) interventional radiotherapy treatments can improve clinical outcomes and how to implement these. (brighttalk.com)
  • The Varian Advanced Radiotherapy Clinical School involves case-based learning with expert clinicians from some of the leading cancer centers in the country. (varian.com)
  • Reduced oxygen levels (hypoxia) is one of the most important factors influencing clinical outcome after radiotherapy. (nih.gov)
  • The aim of this Review is to critically assess the potential use of imaging to help improve clinical outcome to radiotherapy. (nih.gov)
  • The Advanced Radiotherapy Center carries out research activities aimed at promoting radiosurgery quantitative and qualitative analyses, and developing a wider disease category database, clinical guidelines, and practices in cooperation with the UPMC Hillman Cancer Center network and other Italian and European cancer centers. (upmc.com)
  • Clinical radiotherapy for cancer has seen dramatic improvements in recent years, driven by developments in imaging and delivery techniques. (europa.eu)
  • And, as important as the clinical benefits are, the true breakthrough may relate to easy and convenient access to partial breast radiotherapy for the tens of thousands of women who today opt for an unnecessary mastectomy or a lumpectomy without radiation therapy. (rxpgnews.com)
  • A well-attended one-day meeting on clinical trials in molecular radiotherapy (MRT) was organised in conjunction with the British Nuclear Medicine Society (BNMS) in London. (ncri.org.uk)
  • With all the capabilities you need in a single platform, Elekta Infinity allows you to expand your radiotherapy program and can help you meet clinical goals for every patient, every time. (elekta.com)
  • Although naming as IMRT in fact, it is only in the combination of fundamental radiotherapy. (geocities.jp)
  • ImagO provides scientific courses on all aspects of medical imaging, radiotherapy physics, intensity modulated radiotherapy (IMRT). (umcutrecht.nl)
  • Women who receive radiotherapy for childhood cancers have increased risk of their pregnancies resulting in stillbirth, BBC News has reported. (www.nhs.uk)
  • The four patients who did not receive radiotherapy died of the disease at 0.6, 1.0, 1.9, and 2.4 months after diagnosis. (nih.gov)
  • You will not actually receive radiotherapy during this session. (newcastle-hospitals.org.uk)
  • We have already shown that during the course of radiotherapy the anatomical structure can differ and the cancer change position inside the chest," explained Dr Khalil. (eurekalert.org)
  • Radiotherapy, otherwise called as radiation therapy, X-ray radiation or irradiation is the medical use of ionizing radiation to control/destroy malignant cells and shrink tumors. (medindia.net)
  • One reason that radiotherapy - which uses ionizing radiation - can shrink or eliminate tumors is because it increases production of ROS inside cancer cells. (medicalnewstoday.com)
  • These machines can perform SRS in a single session or over two to five sessions for larger tumors (fractionated stereotactic radiotherapy). (mayoclinic.org)
  • It can use fractionated stereotactic radiotherapy to treat body tumors over several sessions. (mayoclinic.org)
  • The TrueBeam™ Radiotherapy System, available at Morristown Medical Center , allows us to precisely target these types of tumors with high doses of radiation while sparing most of the surrounding healthy tissue in the process. (atlantichealth.org)
  • Radiotherapy (RT) has been considered a local modality and outcomes have emphasized local and regional control of tumors. (frontiersin.org)
  • Plaque radiotherapy is a type of radiation therapy used to treat eye tumors. (wikipedia.org)
  • Radiotherapy of intraocular and orbital tumors. (wikipedia.org)
  • Dramatic changes were seen in the delivery of radiotherapy treatments for cancer during the first wave of the coronavirus pandemic in England. (news-medical.net)
  • Some cancers, however, become resistant to radiotherapy and other treatments that work by increasing ROS in cancer cells because the cells develop a tolerance to the molecules. (medicalnewstoday.com)
  • Radiotherapy often requires several treatments and the costs average between £585 and £2,275 per series, depending on the types of equipment used, the lab expenses and professional fees. (ehow.co.uk)
  • Within this centre the newest MRI guided tumour treatments are being investigated in a close collaboration between Radiotherapy, Radiology and our industrial partners Elekta and Philips. (umcutrecht.nl)
  • biopsied prostate cancer patients at diagnosis and before and after castration and radiotherapy treatments to monitor the molecular events that might explain this improved response. (sciencemag.org)
  • Radiotherapy remains one of the standard treatments against cancer, being delivered to millions of EU patients every year. (europa.eu)
  • 90% of the breast cancers in Hodgkin's lymphoma patients receiving radiation are due to radiotherapy-associated uses. (greenmedinfo.com)
  • Many cancers respond positively to radiotherapy. (ehow.co.uk)
  • Indeed, radiotherapy and hormone therapy are combined in a neoadjuvant and concomitant setting for intermediate risk cancers but also in an adjuvant setting in high risk or locally advanced prostate cancer. (urotoday.com)
  • Internal radiotherapy is used only for certain types of cancer, such as prostate cancer, some gynaecological cancers, thyroid cancer, cancer in the liver, and some head and neck cancers. (cancervic.org.au)
  • Radiotherapy uses high energy x-rays to kill cancer cells and shrink cancers. (leukaemia.org.au)
  • Radiotherapy was associated with an increased risk of second non-breast cancers. (greenmedinfo.com)
  • Accurate dosimetry is essential to maintain and improve radiotherapy and, ultimately, to improve cancer survival rates. (npl.co.uk)
  • We provide world-class research, calibrations, specialised measurement services and training for the dosimetry of ionising radiation in cancer therapy and diagnostic X-rays, including a full range of radiotherapy auditing services. (npl.co.uk)
  • IAEA/WHO dosimetry audit service offered to radiotherapy centres around the world now includes high energy electron beams for newly installed linacs. (iaea.org)
  • The IAEA and the World Health Organization (WHO) have rolled out a new type of dosimetry audit as a cost-free service to radiotherapy centres around the world to support hospitals in tackling the growing cancer burden. (iaea.org)
  • This book is a collection of current ideas concerned with the optimization of human cancer radiotherapy. (springer.com)
  • Seven patients were referred in our department for postoperative breast cancer radiotherapy. (nih.gov)
  • Long term side effects of penile cancer radiotherapy are more likely with higher doses of radiation. (cancerresearchuk.org)
  • Current role of spacers for prostate cancer radiotherapy. (urotoday.com)
  • Unsealed source radiotherapy (also known as unsealed source radionuclide therapy (RNT) or molecular radiotherapy) uses radioactive substances called radiopharmaceuticals to treat medical conditions, particularly cancer. (wikipedia.org)
  • Fiona McKirdy (CTRad's Radiotherapy Technology Project Manager) then presented an update on the Molecular Radiotherapy research review. (ncri.org.uk)
  • Palliative radiotherapy can also be used to relieve local symptoms like dysphagia or bleeding. (springer.com)
  • This is called palliative radiotherapy. (macmillan.org.uk)
  • In the management of metastatic bone pain, systematic reviews support the effectiveness of palliative radiotherapy [9] and bisphosphonates. (caresearch.com.au)
  • Rapid Response Radiotherapy Program at the Odette Cancer Centre began in 1996 to provide timely palliative radiotherapy to relieve symptoms in patients with advanced cancer. (sunnybrook.ca)
  • Approximately 7% of breast cancer patients who undergo radiotherapy may develop loco-regional tumour recurrence within 5 years. (greenmedinfo.com)
  • Brain cancer patients who undergo radiotherapy may face a higher risk of accelerated mental decline in later life, new research suggests. (netdoctor.co.uk)
  • Scientists have recently identified a molecular pathway that links the movement of energy-producing centers, or mitochondria, in cancer cells to resistance to radiotherapy. (medicalnewstoday.com)
  • Proton beam (charged particle) is the newest type of stereotactic radiotherapy and is available in only a few research centers in the U.S., although the number of centers offering proton beam therapy has greatly increased in the last few years. (mayoclinic.org)
  • Stereotactic radiosurgery (SRS) is a type of radiotherapy. (mayoclinic.org)
  • All types of stereotactic radiosurgery and radiotherapy work in a similar manner. (mayoclinic.org)
  • It is distinct from our versatile TrueBeam radiotherapy and radiosurgery platform in that VitalBeam is optimized for advanced radiotherapy while TrueBeam systems were designed to handle both. (varian.com)
  • This course is ideal for teams of clinicians who work together to plan and deliver radiotherapy, and it can also greatly benefit individual radiation oncologists, medical physicists and dosimetrists. (varian.com)
  • It is an invaluable teaching guide and reference for all medical physicists and radiation oncologists/therapists that use conformal radiotherapy. (routledge.com)
  • RAD Review "…authoritative … [the book] describes the physics and methodology of conformal radiotherapy … useful to both experienced and novice medical physicists and radiotherapists. (routledge.com)
  • Sometimes this is referred to as stereotactic ablative radiotherapy (SABR). (mayoclinic.org)
  • Figure 2: The toxicity of radiotherapy. (nature.com)
  • A man has dreamed in colour for the first time after undergoing radiotherapy to treat a tumour on his eye. (newscientist.com)
  • However, there was no difference between the two groups in the rates of recurrence of cancer or the failure of the radiotherapy to control tumour growth. (eurekalert.org)
  • Yes he had radical prostatectomy in Feb and starts radiotherapy in Sept sorry (I normally hate abreviations myself! (medhelp.org)
  • Early' salvage radiotherapy (SRT) following radical prostatectomy (RP) for prostate cancer is commonly advocated in place of adjuvant radiotherapy. (urotoday.com)
  • Four patients were treated with conserving surgery followed by breast radiotherapy and two with mastectomy followed by chest wall and internal mammary chain, supra- and infra-clavicular lymph node irradiation. (nih.gov)
  • Patients will be stratified according to whether they are receiving radiotherapy alone or chemo irradiation to ensure equal distribution across the different mouth care regimes. (clinicaltrials.gov)
  • Intraoperative radiotherapy (IORT) for early stage breast cancer is a technique for partial breast irradiation. (frontiersin.org)
  • According to research published online in The FASEB Journal , repeated irradiation of breast fat (also known as adipose tissue) produces an inflammatory response that ultimately reduces the efficiency of radiotherapy in breast cancer patients. (eurekalert.org)
  • The impact of radiotherapy on survival in patients with GC remains undefined. (nih.gov)
  • The aim of this article series is to introduce our readers to different immunological aspects of radiotherapy and to show which new avenues of research are currently opening up. (biomedcentral.com)
  • This reading-tutorial course consists of 24 modules covering various aspects of Radiotherapy Physics. (edu.au)
  • Androgen deprivation therapy (castration) combined with radiotherapy improves the overall response to radiotherapy in patients with localized intermediate- and high-risk prostate cancer. (sciencemag.org)
  • This correlated with an increase in unrepaired DNA double-strand breaks caused by radiotherapy, explaining how castration improved the response to radiotherapy. (sciencemag.org)
  • These findings provide mechanistic insight into why castration improves the overall response to radiotherapy in prostate cancer patients. (sciencemag.org)
  • Variation in sensitivity to radiation is an inherited genetic trait and recent progress in genotyping raises the possibility of genome-wide studies to characterize genetic profiles that predict patient response to radiotherapy. (nature.com)
  • 10] Whilst bisphosphonates have no immediate analgesic effect, they are recommended as an adjuvant where the response to radiotherapy and analgesia are inadequate. (caresearch.com.au)
  • Just as I expected': A longitudinal cohort study of the impact of response expectancies on side effect experiences during radiotherapy for prostate cancer. (urotoday.com)
  • McKay hopes other people will come forward if they have had similar dream-altering experiences during radiotherapy, so the phenomenon can be studied further. (newscientist.com)
  • However, successive research studies had conflicting results about the efficacy of radiotherapy in rheumatoid arthritis. (news-medical.net)
  • Tepper J, Krasna MJ, Niedzwiecki D et al (2008) Phase III trial of trimodality therapy with cisplatin, fluorouracil, radiotherapy, and surgery compared with surgery alone for esophageal cancer: CALGB 9781. (springer.com)
  • Intraoperative radiotherapy (IORT) is one such technique. (frontiersin.org)
  • A comprehensive guide to the problems and techniques of quality assurance in radiotherapy. (who.int)
  • Other talks included steps in the trial development process, Radiotherapy Trials Quality Assurance (RTTQA) and patient and public involvement. (ncri.org.uk)
  • Radiotherapy is often given as sessions called fractions. (macmillan.org.uk)
  • Radiotherapy is usually given in small doses (also known as fractions) each week day (Monday to Friday) over a few weeks in the radiotherapy department of the hospital. (leukaemia.org.au)
  • This book deals in detail with all aspects of the best practice in modern radiotherapy for Hodgkin lymphoma. (springer.com)
  • Acute and long-term side effects of radiotherapy are analyzed, and the implications for modern radiotherapy approaches in Hodgkin lymphomas are explained. (springer.com)
  • Patients with permanent cardiac pacemakers occasionally require radiotherapy. (nih.gov)
  • Adjuvant and Salvage Radiotherapy after Prostatectomy: ASTRO/AUA Guideline. (medscape.com)
  • Very Early' Salvage Radiotherapy Improves Distant Metastasis-Free Survival. (urotoday.com)
  • Breast preserving surgery with adjuvant radiotherapy is as effective as mastectomy in the early stages of breast cancer to control local disease and distant metastasis and maintain the overall survival rate. (magiran.com)
  • However، the complications of adjuvant radiotherapy remain a challenge. (magiran.com)
  • Anal and rectal function after intensity-modulated prostate radiotherapy with endorectal balloon. (urotoday.com)
  • Two main divisions of radiotherapy are external radiotherapy and internal radiotherapy , the difference being that in external radiotherapy, the radiation source is from outside the body whereas in internal radiotherapy radioactive material is implanted within the body. (everything2.com)
  • Internal radiotherapy means giving radiotherapy to the cancer from inside the penis. (cancerresearchuk.org)
  • Your doctor may recommend internal radiotherapy alone or in combination with external radiotherapy . (cancervic.org.au)
  • More than half of patients who had undergone radiotherapy suffered from mental decline, compared with just 27 per cent of patients who had not. (netdoctor.co.uk)
  • We report a lymphoma case, where the patient had undergone radiotherapy for the bilateral neck and bilateral supraclavicular/infraclavicular area. (hindawi.com)
  • Surgery Versus Radiotherapy for Clinically-localized Prostate Cancer: A Systematic Review and Meta-analysis. (medscape.com)
  • First, it established that it's still common practice for physicians to advise breast cancer patients to avoid antiperspirants during radiotherapy. (eurekalert.org)
  • The Swedish Council on Technology Assessment in Health Care (SBU) systematic overview of radiotherapy for cancer including a prospective survey of radiotherapy practice in Sweden 2001 - summary and conclusions. (nature.com)
  • The patient was given three-dimensional conformal radiotherapy targeted to the involved field since 14th March, 2013. (hindawi.com)
  • The Physics of Conformal Radiotherapy: Advances in Technology provides a thorough overview of conformal radiotherapy and biological modeling, focusing on the underlying physics and methodology of three-dimensional techniques in radiation therapy. (routledge.com)
  • ASLIB Book Guide "…a useful introduction and review of a number of developing areas in conformal radiotherapy, providing valuable explanations of the theories behind the state of the art equipment. (routledge.com)
  • P. Metclafe, T. Kron and P. Hoban, The Physics of Radiotherapy X-Rays from Linear Accelerators, Medical Physics Publishing, Madison (1997). (edu.au)
  • Second neoplasms after percutaneous radiotherapy. (medworm.com)
  • Radiotherapy and androgen deprivation therapy play a major role in the management of prostate cancer. (urotoday.com)
  • Radiotherapy for breast cancer and pacemaker]. (nih.gov)
  • From November 2008 to December 2009, more than 900 patients received radiotherapy for their breast cancer in our department using megavoltage linear accelerator (X 4-6 MV and electrons). (nih.gov)
  • Patients often undergo 25 daily doses of radiotherapy to the whole breast after surgical removal of the tumor to ensure that any remaining breast cancer cells are destroyed," said David N. Brindley, Ph.D., D.Sc. (eurekalert.org)
  • Radiotherapy is commonly applied to the cancerous tumor because of its ability to control cell growth. (amc.nl)
  • Late cardiac toxicities caused by (particularly left-sided) breast radiotherapy (RT) are now recognized as rare but relevant sequelae, which has prompted research on risk structure identification and definition of threshold doses to heart subvolumes. (springer.com)
  • The main research line of the department is MRI guided radiotherapy (MRIgRT). (umcutrecht.nl)
  • The DOSEO radiotherapy research and training center recently created a new training course combining theoretical and hands-on learning over three two-day sessions. (cea.fr)
  • Aquilab, France's leading provider of medical imaging and radiotherapy equipment quality control and software solutions, signed a research contract with DOSEO to test and validate a new beam control method. (cea.fr)
  • Global Internal Beam Radiotherapy Market detailed in new research. (mynewsdesk.com)
  • This Internal Beam Radiotherapy market research is an intelligence report with meticulous efforts undertaken to study the right and valuable information. (mynewsdesk.com)