Compounds that are used in medicine as sources of radiation for radiotherapy and for diagnostic purposes. They have numerous uses in research and industry. (Martindale, The Extra Pharmacopoeia, 30th ed, p1161)
A specialty field of radiology concerned with diagnostic, therapeutic, and investigative use of radioactive compounds in a pharmaceutical form.
The first artificially produced element and a radioactive fission product of URANIUM. Technetium has the atomic symbol Tc, atomic number 43, and atomic weight 98.91. All technetium isotopes are radioactive. Technetium 99m (m=metastable) which is the decay product of Molybdenum 99, has a half-life of about 6 hours and is used diagnostically as a radioactive imaging agent. Technetium 99 which is a decay product of technetium 99m, has a half-life of 210,000 years.
Isotopes that exhibit radioactivity and undergo radioactive decay. (From Grant & Hackh's Chemical Dictionary, 5th ed & McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
The study of the chemical and physical phenomena of radioactive substances.
Unstable isotopes of gallium that decay or disintegrate emitting radiation. Ga atoms with atomic weights 63-68, 70 and 72-76 are radioactive gallium isotopes.
The production of an image obtained by cameras that detect the radioactive emissions of an injected radionuclide as it has distributed differentially throughout tissues in the body. The image obtained from a moving detector is called a scan, while the image obtained from a stationary camera device is called a scintiphotograph.
Rhenium. A metal, atomic number 75, atomic weight 186.2, symbol Re. (Dorland, 28th ed)
A trace element that is required in bone formation. It has the atomic symbol Sn, atomic number 50, and atomic weight 118.71.
Inorganic compounds that contain TECHNETIUM as an integral part of the molecule. Technetium 99m (m=metastable) is an isotope of technetium that has a half-life of about 6 hours. Technetium 99, which has a half-life of 210,000 years, is a decay product of technetium 99m.
Polonium. A radioactive element that is a member of the chalcogen family. It has the atomic symbol Po, atomic number 84, and the atomic weight of the isotope with the longest half-life (209Po) is 208.98. It decays by alpha-emission.
Organic compounds that contain technetium as an integral part of the molecule. These compounds are often used as radionuclide imaging agents.
Separation systems containing a relatively long-lived parent radionuclide which produces a short-lived daughter in its decay scheme. The daughter can be periodically extracted (milked) by means of an appropriate eluting agent.
An iron chelating agent with properties like EDETIC ACID. DTPA has also been used as a chelator for other metals, such as plutonium.
Techniques for labeling a substance with a stable or radioactive isotope. It is not used for articles involving labeled substances unless the methods of labeling are substantively discussed. Tracers that may be labeled include chemical substances, cells, or microorganisms.
The amount of radiation energy that is deposited in a unit mass of material, such as tissues of plants or animal. In RADIOTHERAPY, radiation dosage is expressed in gray units (Gy). In RADIOLOGIC HEALTH, the dosage is expressed by the product of absorbed dose (Gy) and quality factor (a function of linear energy transfer), and is called radiation dose equivalent in sievert units (Sv).
Unstable isotopes of mercury that decay or disintegrate emitting radiation. Hg atoms with atomic weights 185-195, 197, 203, 205, and 206 are radioactive mercury isotopes.
Unstable isotopes of copper that decay or disintegrate emitting radiation. Cu atoms with atomic weights 58-62, 64, and 66-68 are radioactive copper isotopes.
Accumulation of a drug or chemical substance in various organs (including those not relevant to its pharmacologic or therapeutic action). This distribution depends on the blood flow or perfusion rate of the organ, the ability of the drug to penetrate organ membranes, tissue specificity, protein binding. The distribution is usually expressed as tissue to plasma ratios.
Samarium. An element of the rare earth family of metals. It has the atomic symbol Sm, atomic number 62, and atomic weight 150.36. The oxide is used in the control rods of some nuclear reactors.
Measurement of radioactivity in the entire human body.
The measurement of radiation by photography, as in x-ray film and film badge, by Geiger-Mueller tube, and by SCINTILLATION COUNTING.
Unstable isotopes of indium that decay or disintegrate emitting radiation. In atoms with atomic weights 106-112, 113m, 114, and 116-124 are radioactive indium isotopes.
The spontaneous transformation of a nuclide into one or more different nuclides, accompanied by either the emission of particles from the nucleus, nuclear capture or ejection of orbital electrons, or fission. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)
Small computers that lack the speed, memory capacity, and instructional capability of the full-size computer but usually retain its programmable flexibility. They are larger, faster, and more flexible, powerful, and expensive than microcomputers.
Unstable isotopes of iodine that decay or disintegrate emitting radiation. I atoms with atomic weights 117-139, except I 127, are radioactive iodine isotopes.
An imaging technique using compounds labelled with short-lived positron-emitting radionuclides (such as carbon-11, nitrogen-13, oxygen-15 and fluorine-18) to measure cell metabolism. It has been useful in study of soft tissues such as CANCER; CARDIOVASCULAR SYSTEM; and brain. SINGLE-PHOTON EMISSION-COMPUTED TOMOGRAPHY is closely related to positron emission tomography, but uses isotopes with longer half-lives and resolution is lower.
A class of compounds of the type R-M, where a C atom is joined directly to any other element except H, C, N, O, F, Cl, Br, I, or At. (Grant & Hackh's Chemical Dictionary, 5th ed)
A metallic element, atomic number 49, atomic weight 114.82, symbol In. It is named from its blue line in the spectrum. (From Dorland, 28th ed)
A gamma-emitting radionuclide imaging agent used for the diagnosis of diseases in many tissues, particularly in the gastrointestinal system, cardiovascular and cerebral circulation, brain, thyroid, and joints.
Astatine. A radioactive halogen with the atomic symbol At, atomic number 85, and atomic weight 210. Its isotopes range in mass number from 200 to 219 and all have an extremely short half-life. Astatine may be of use in the treatment of hyperthyroidism.
A nontoxic radiopharmaceutical that is used in RADIONUCLIDE IMAGING for the clinical evaluation of hepatobiliary disorders in humans.
The ratio of radiation dosages required to produce identical change based on a formula comparing other types of radiation with that of gamma or roentgen rays.
Radioactive substances added in minute amounts to the reacting elements or compounds in a chemical process and traced through the process by appropriate detection methods, e.g., Geiger counter. Compounds containing tracers are often said to be tagged or labeled. (Hawley's Condensed Chemical Dictionary, 12th ed)
A gamma-emitting radionuclide imaging agent used primarily in skeletal scintigraphy. Because of its absorption by a variety of tumors, it is useful for the detection of neoplasms.
The total amount of a chemical, metal or radioactive substance present at any time after absorption in the body of man or animal.
Positively charged particles composed of two protons and two NEUTRONS, i.e. equivalent to HELIUM nuclei, which are emitted during disintegration of heavy ISOTOPES. Alpha rays have very strong ionizing power, but weak penetrability.
Radium. A radioactive element of the alkaline earth series of metals. It has the atomic symbol Ra, atomic number 88, and atomic weight 226. Radium is the product of the disintegration of uranium and is present in pitchblende and all ores containing uranium. It is used clinically as a source of beta and gamma-rays in radiotherapy, particularly BRACHYTHERAPY.
Inorganic compounds that contain tin as an integral part of the molecule.
A method of computed tomography that uses radionuclides which emit a single photon of a given energy. The camera is rotated 180 or 360 degrees around the patient to capture images at multiple positions along the arc. The computer is then used to reconstruct the transaxial, sagittal, and coronal images from the 3-dimensional distribution of radionuclides in the organ. The advantages of SPECT are that it can be used to observe biochemical and physiological processes as well as size and volume of the organ. The disadvantage is that, unlike positron-emission tomography where the positron-electron annihilation results in the emission of 2 photons at 180 degrees from each other, SPECT requires physical collimation to line up the photons, which results in the loss of many available photons and hence degrades the image.
Organic chemistry methodology that mimics the modular nature of various biosynthetic processes. It uses highly reliable and selective reactions designed to "click" i.e., rapidly join small modular units together in high yield, without offensive byproducts. In combination with COMBINATORIAL CHEMISTRY TECHNIQUES, it is used for the synthesis of new compounds and combinatorial libraries.
A nonmetallic, diatomic gas that is a trace element and member of the halogen family. It is used in dentistry as flouride (FLUORIDES) to prevent dental caries.
Unstable isotopes of yttrium that decay or disintegrate emitting radiation. Y atoms with atomic weights 82-88 and 90-96 are radioactive yttrium isotopes.
Tomography using radioactive emissions from injected RADIONUCLIDES and computer ALGORITHMS to reconstruct an image.
Unstable isotopes of fluorine that decay or disintegrate emitting radiation. F atoms with atomic weights 17, 18, and 20-22 are radioactive fluorine isotopes.
A compound forming white, odorless deliquescent crystals and used as iodine supplement, expectorant or in its radioactive (I-131) form as an diagnostic aid, particularly for thyroid function tests.
Ytterbium. An element of the rare earth family of metals. It has the atomic symbol Yb, atomic number 70, and atomic weight 173. Ytterbium has been used in lasers and as a portable x-ray source.
The application of scientific knowledge or technology to the field of radiology. The applications center mostly around x-ray or radioisotopes for diagnostic and therapeutic purposes but the technological applications of any radiation or radiologic procedure is within the scope of radiologic technology.
An antiseptic with mild fungistatic, bacteriostatic, anthelmintic, and amebicidal action. It is also used as a reagent and metal chelator, as a carrier for radio-indium for diagnostic purposes, and its halogenated derivatives are used in addition as topical anti-infective agents and oral antiamebics.
A rare, metallic element designated by the symbol, Ga, atomic number 31, and atomic weight 69.72.
A gamma-emitting radionuclide imaging agent used for the diagnosis of diseases in many tissues, particularly in cardiovascular and cerebral circulation.
Unstable isotopes of cobalt that decay or disintegrate emitting radiation. Co atoms with atomic weights of 54-64, except 59, are radioactive cobalt isotopes.
Hospital department responsible for the administration and management of nuclear medicine services.
The compound is given by intravenous injection to do POSITRON-EMISSION TOMOGRAPHY for the assessment of cerebral and myocardial glucose metabolism in various physiological or pathological states including stroke and myocardial ischemia. It is also employed for the detection of malignant tumors including those of the brain, liver, and thyroid gland. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1162)
A nontoxic radiopharmaceutical that is used in the diagnostic imaging of the renal cortex.
Neutral or negatively charged ligands bonded to metal cations or neutral atoms. The number of ligand atoms to which the metal center is directly bonded is the metal cation's coordination number, and this number is always greater than the regular valence or oxidation number of the metal. A coordination complex can be negative, neutral, or positively charged.
Inorganic salts of phosphoric acid that contain two phosphate groups.
A technetium diagnostic aid used in renal function determination.
A guanidine analog with specific affinity for tissues of the sympathetic nervous system and related tumors. The radiolabeled forms are used as antineoplastic agents and radioactive imaging agents. (Merck Index, 12th ed) MIBG serves as a neuron-blocking agent which has a strong affinity for, and retention in, the adrenal medulla and also inhibits ADP-ribosyltransferase.
A gamma-emitting radionuclide imaging agent used for the diagnosis of diseases in many tissues, particularly in the gastrointestinal system, liver, and spleen.
The observation, either continuously or at intervals, of the levels of radiation in a given area, generally for the purpose of assuring that they have not exceeded prescribed amounts or, in case of radiation already present in the area, assuring that the levels have returned to those meeting acceptable safety standards.
Cell surface proteins that bind somatostatin and trigger intracellular changes which influence the behavior of cells. Somatostatin is a hypothalamic hormone, a pancreatic hormone, and a central and peripheral neurotransmitter. Activated somatostatin receptors on pituitary cells inhibit the release of growth hormone; those on endocrine and gastrointestinal cells regulate the absorption and utilization of nutrients; and those on neurons mediate somatostatin's role as a neurotransmitter.
An inhibitor of the enzyme TYROSINE 3-MONOOXYGENASE, and consequently of the synthesis of catecholamines. It is used to control the symptoms of excessive sympathetic stimulation in patients with PHEOCHROMOCYTOMA. (Martindale, The Extra Pharmacopoeia, 30th ed)
Tumors whose cells possess secretory granules and originate from the neuroectoderm, i.e., the cells of the ectoblast or epiblast that program the neuroendocrine system. Common properties across most neuroendocrine tumors include ectopic hormone production (often via APUD CELLS), the presence of tumor-associated antigens, and isozyme composition.
Volume of biological fluid completely cleared of drug metabolites as measured in unit time. Elimination occurs as a result of metabolic processes in the kidney, liver, saliva, sweat, intestine, heart, brain, or other site.
A technetium imaging agent used to reveal blood-starved cardiac tissue during a heart attack.
Organic compounds that contain phosphorus as an integral part of the molecule. Included under this heading is broad array of synthetic compounds that are used as PESTICIDES and DRUGS.
Chemicals that bind to and remove ions from solutions. Many chelating agents function through the formation of COORDINATION COMPLEXES with METALS.
A potent, long-acting synthetic SOMATOSTATIN octapeptide analog that inhibits secretion of GROWTH HORMONE and is used to treat hormone-secreting tumors; DIABETES MELLITUS; HYPOTENSION, ORTHOSTATIC; HYPERINSULINISM; hypergastrinemia; and small bowel fistula.
Radiotherapy where cytotoxic radionuclides are linked to antibodies in order to deliver toxins directly to tumor targets. Therapy with targeted radiation rather than antibody-targeted toxins (IMMUNOTOXINS) has the advantage that adjacent tumor cells, which lack the appropriate antigenic determinants, can be destroyed by radiation cross-fire. Radioimmunotherapy is sometimes called targeted radiotherapy, but this latter term can also refer to radionuclides linked to non-immune molecules (see RADIOTHERAPY).
An amphetamine analog that is rapidly taken up by the lungs and from there redistributed primarily to the brain and liver. It is used in brain radionuclide scanning with I-123.
Use of radiolabeled antibodies for diagnostic imaging of neoplasms. Antitumor antibodies are labeled with diverse radionuclides including iodine-131, iodine-123, indium-111, or technetium-99m and injected into the patient. Images are obtained by a scintillation camera.
A gamma-emitting RADIONUCLIDE IMAGING agent used in the evaluation of regional cerebral blood flow and in non-invasive dynamic biodistribution studies and MYOCARDIAL PERFUSION IMAGING. It has also been used to label leukocytes in the investigation of INFLAMMATORY BOWEL DISEASES.
Tumors or cancer located in bone tissue or specific BONES.
Compounds that contain the radical R2C=N.OH derived from condensation of ALDEHYDES or KETONES with HYDROXYLAMINE. Members of this group are CHOLINESTERASE REACTIVATORS.
Imaging methods that result in sharp images of objects located on a chosen plane and blurred images located above or below the plane.
Any visual display of structural or functional patterns of organs or tissues for diagnostic evaluation. It includes measuring physiologic and metabolic responses to physical and chemical stimuli, as well as ultramicroscopy.
Two-phase systems in which one is uniformly dispersed in another as particles small enough so they cannot be filtered or will not settle out. The dispersing or continuous phase or medium envelops the particles of the discontinuous phase. All three states of matter can form colloids among each other.
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.
A technetium imaging agent used in renal scintigraphy, computed tomography, lung ventilation imaging, gastrointestinal scintigraphy, and many other procedures which employ radionuclide imaging agents.
Unstable isotopes of carbon that decay or disintegrate emitting radiation. C atoms with atomic weights 10, 11, and 14-16 are radioactive carbon isotopes.
Devices or objects in various imaging techniques used to visualize or enhance visualization by simulating conditions encountered in the procedure. Phantoms are used very often in procedures employing or measuring x-irradiation or radioactive material to evaluate performance. Phantoms often have properties similar to human tissue. Water demonstrates absorbing properties similar to normal tissue, hence water-filled phantoms are used to map radiation levels. Phantoms are used also as teaching aids to simulate real conditions with x-ray or ultrasonic machines. (From Iturralde, Dictionary and Handbook of Nuclear Medicine and Clinical Imaging, 1990)
The total amount of radiation absorbed by tissues as a result of radiotherapy.
The use of molecularly targeted imaging probes to localize and/or monitor biochemical and cellular processes via various imaging modalities that include RADIONUCLIDE IMAGING; ULTRASONOGRAPHY; MAGNETIC RESONANCE IMAGING; FLUORESCENCE IMAGING; and MICROSCOPY.
A system for verifying and maintaining a desired level of quality in a product or process by careful planning, use of proper equipment, continued inspection, and corrective action as required. (Random House Unabridged Dictionary, 2d ed)
The making of a radiograph of an object or tissue by recording on a photographic plate the radiation emitted by radioactive material within the object. (Dorland, 27th ed)
Systems for the delivery of drugs to target sites of pharmacological actions. Technologies employed include those concerning drug preparation, route of administration, site targeting, metabolism, and toxicity.
The hollow, muscular organ that maintains the circulation of the blood.
The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065)
The relationship between the dose of administered radiation and the response of the organism or tissue to the radiation.
Organic compounds which contain P-C-P bonds, where P stands for phosphonates or phosphonic acids. These compounds affect calcium metabolism. They inhibit ectopic calcification and slow down bone resorption and bone turnover. Technetium complexes of diphosphonates have been used successfully as bone scanning agents.
Experimental transplantation of neoplasms in laboratory animals for research purposes.
Studies determining the effectiveness or value of processes, personnel, and equipment, or the material on conducting such studies. For drugs and devices, CLINICAL TRIALS AS TOPIC; DRUG EVALUATION; and DRUG EVALUATION, PRECLINICAL are available.
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
Mutant mice homozygous for the recessive gene "nude" which fail to develop a thymus. They are useful in tumor studies and studies on immune responses.
Characteristic restricted to a particular organ of the body, such as a cell type, metabolic response or expression of a particular protein or antigen.
Methods of creating machines and devices.
Tomography using x-ray transmission and a computer algorithm to reconstruct the image.
Tumors or cancer of the PROSTATE.
Theoretical representations that simulate the behavior or activity of biological processes or diseases. For disease models in living animals, DISEASE MODELS, ANIMAL is available. Biological models include the use of mathematical equations, computers, and other electronic equipment.
Neoplasms of the intracranial components of the central nervous system, including the cerebral hemispheres, basal ganglia, hypothalamus, thalamus, brain stem, and cerebellum. Brain neoplasms are subdivided into primary (originating from brain tissue) and secondary (i.e., metastatic) forms. Primary neoplasms are subdivided into benign and malignant forms. In general, brain tumors may also be classified by age of onset, histologic type, or presenting location in the brain.
The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM.
The species Oryctolagus cuniculus, in the family Leporidae, order LAGOMORPHA. Rabbits are born in burrows, furless, and with eyes and ears closed. In contrast with HARES, rabbits have 22 chromosome pairs.
The statistical reproducibility of measurements (often in a clinical context), including the testing of instrumentation or techniques to obtain reproducible results. The concept includes reproducibility of physiological measurements, which may be used to develop rules to assess probability or prognosis, or response to a stimulus; reproducibility of occurrence of a condition; and reproducibility of experimental results.
Members of the class of compounds composed of AMINO ACIDS joined together by peptide bonds between adjacent amino acids into linear, branched or cyclical structures. OLIGOPEPTIDES are composed of approximately 2-12 amino acids. Polypeptides are composed of approximately 13 or more amino acids. PROTEINS are linear polypeptides that are normally synthesized on RIBOSOMES.
Elements of limited time intervals, contributing to particular results or situations.
Antibodies produced by a single clone of cells.
The movement of materials (including biochemical substances and drugs) through a biological system at the cellular level. The transport can be across cell membranes and epithelial layers. It also can occur within intracellular compartments and extracellular compartments.
Liquid chromatographic techniques which feature high inlet pressures, high sensitivity, and high speed.
Body organ that filters blood for the secretion of URINE and that regulates ion concentrations.
Tumors or cancer of the human BREAST.

Cardiac sympathetic activity estimated by 123I-MIBG myocardial imaging in patients with dilated cardiomyopathy after beta-blocker or angiotensin-converting enzyme inhibitor therapy. (1/6785)

Impaired cardiac sympathetic activity can be evaluated by 123I-metaiodobenzylguanidine (MIBG) imaging. METHODS: We studied the significance of MIBG imaging for 24 patients (age 58+/-12 y) with dilated cardiomyopathy (DCM). We compared 12 patients (group A) treated with metoprolol (dose from 30-60 mg/d) with 12 patients treated with angiotensin-converting enzyme (ACE) inhibitors. Patients were studied before treatment, after 5 mo of treatment (only in group A) and after 1 y of treatment. Cardiac MIBG uptake was assessed as the heart-to-mediastinum activity ratio (H/M) and total defect score (TDS) from anterior planar and SPECT MIBG images, which were acquired in 4 h after tracer injection. New York Heart Association (NYHA) class and left ventricular ejection fraction (LVEF) calculated by echocardiography were also assessed. RESULTS: TDS decreased in both groups (in group A, from 30+/-7 through 23+/-9 to 18+/-10; P < 0.01, in group B, from 30+/-6 to 24+/-8; P < 0.01) and H/M was increased in both groups (in group A, from 1.87+/-0.31 through 2.03+/-0.28 to 2.14+/-0.29; P < 0.01, in group B, from 1.82+/-0.28 to 1.94+/-0.26; P < 0.05). But TDS and H/M were more improved in group A than in group B (P < 0.05). LVEF was significantly increased in only group A (from 38+/-6 through 43+/-8 to 49%+/-9%; P < 0.01). NYHA improved in both groups (in group A, from mean 2.5 through 2.1 to 1.8; P < 0.01, in group B, from mean 2.6 to 2.1; P < 0.05) but was more improved in group A than in group B (P < 0.05). CONCLUSION: Cardiac function, symptom and cardiac sympathetic activity evaluated by MIBG images improved after the beta-blocker therapy more than with the treatment that used ACE inhibitors.  (+info)

Sympathetic nerve alterations assessed with 123I-MIBG in the failing human heart. (2/6785)

Norepinephrine (NE) reuptake function is impaired in heart failure and this may participate in myocyte hyperstimulation by the neurotransmitter. This alteration can be assessed by 123I-metaiodobenzylguanidine (MIBG) scintigraphy. METHODS: To determine whether the impairment of neuronal NE reuptake was reversible after metoprolol therapy, we studied 18 patients (43+/-7 y) with idiopathic dilated cardiomyopathy who were stabilized at least for 3 mo with captopril and diuretics. Patients underwent, before and after 6 mo of therapy with metoprolol, measurements of radionuclide left ventricular ejection fraction (LVEF), maximal oxygen consumption and plasma NE concentration. The cardiac adrenergic innervation function was scintigraphically assessed with MIBG uptake and release measurements on the planar images obtained 20 min and 4 h after tracer injection. To evaluate whether metoprolol had a direct interaction with cardiac MIBG uptake and release, six normal subjects were studied before and after a 1-mo metoprolol intake. RESULTS: In controls, neither cardiac MIBG uptake and release nor circulating NE concentration changed after the 1-mo metoprolol intake. Conversely, after a 6-mo therapy with metoprolol, patients showed increased cardiac MIBG uptake (129%+/-10% versus 138%+/-17%; P = 0.009), unchanged cardiac MIBG release and decreased plasma NE concentration (0.930+/-412 versus 0.721+/-0.370 ng/mL; P = 0.02). In parallel, patients showed improved New York Heart Association class (2.44+/-0.51 versus 2.05+/-0.23; P = 0.004) and increased LVEF (20%+/-8% versus 27%+/-8%; P = 0.0005), whereas maximal oxygen uptake remained unchanged. CONCLUSION: Thus, a parallel improvement of myocardial NE reuptake and of hemodynamics was observed after a 6-mo metoprolol therapy, suggesting that such agents may be beneficial in heart failure by directly protecting the myocardium against excessive NE stimulation.  (+info)

Sensitivity of [11C]phenylephrine kinetics to monoamine oxidase activity in normal human heart. (3/6785)

Phenylephrine labeled with 11C was developed as a radiotracer for imaging studies of cardiac sympathetic nerves with PET. A structural analog of norepinephrine, (-)-[11C]phenylephrine (PHEN) is transported into cardiac sympathetic nerve varicosities by the neuronal norepinephrine transporter and stored in vesicles. PHEN is also a substrate for monoamine oxidase (MAO). The goal of this study was to assess the importance of neuronal MAO activity on the kinetics of PHEN in the normal human heart. MAO metabolism of PHEN was inhibited at the tracer level by substituting deuterium atoms for the two hydrogen atoms at the alpha-carbon side chain position to yield the MAO-resistant analog D2-PHEN. METHODS: Paired PET studies of PHEN and D2-PHEN were performed in six normal volunteers. Hemodynamic and electrocardiographic responses were monitored. Blood levels of intact radiotracer and radiolabeled metabolites were measured in venous samples taken during the 60 min dynamic PET study. Myocardial retention of the tracers was regionally quantified as a retention index. Tracer efflux between 6 and 50 min after tracer injection was fit to a single exponential process to obtain a washout half-time for all left ventricular regions. RESULTS: Although initial heart uptake of the two tracers was similar, D2-PHEN cleared from the heart 2.6 times more slowly than PHEN (mean half-time 155+/-52 versus 55+/-10 min, respectively; P < 0.01). Correspondingly, heart retention of D2-PHEN at 40-60 min after tracer injection was higher than PHEN (mean retention indices 0.086+/-0.018 versus 0.066+/-0.011 mL blood/ min/mL tissue, respectively; P < 0.003). CONCLUSION: Efflux of radioactivity from normal human heart after uptake of PHEN is primarily due to metabolism of the tracer by neuronal MAO. Related mechanistic studies in the isolated rat heart indicate that vesicular storage of PHEN protects the tracer from rapid metabolism by neuronal MAO, suggesting that MAO metabolism of PHEN leaking from storage vesicles leads to the gradual loss of PHEN from the neurons. Thus, although MAO metabolism influences the rate of clearance of PHEN from the neurons, MAO metabolism is not the rate-determining step in the observed efflux rate under normal conditions. Rather, the rate at which PHEN leaks from storage vesicles is likely to be the rate-limiting step in the observed efflux rate.  (+info)

Enhanced myocardial glucose use in patients with a deficiency in long-chain fatty acid transport (CD36 deficiency). (4/6785)

CD36 is a multifunctional, 88 kDa glycoprotein that is expressed on platelets and monocytes/macrophages. CD36 also has high homology with the long-chain fatty acid (LFA) transporter in the myocardium. Although platelet and monocyte CD36 levels can indicate a CD36 deficiency, they cannot predict specific clinical manifestations in the myocardium of a given person. We examined the hypothesis that a deficiency in LFA transport augments myocardial glucose uptake in patients with a type I CD36 deficiency. METHODS: Seven fasting patients with a type I CD36 deficiency and 9 controls were assessed by cardiac radionuclide imaging using beta-methyl-p-iodophenyl-pentadecanoic acid (BMIPP) as a LFA tracer and by PET with 18F-fluorodeoxyglucose (FDG). RESULTS: None of the patients with a CD36 deficiency showed myocardial uptake of BMIPP. The percentage dose uptake of BMIPP in these subjects was significantly lower than that in normal controls (1.31+/-0.24 versus 2.90+/-0.2; P < 0.005). PET studies revealed that myocardial FDG accumulation was substantially increased in patients with a CD36 deficiency. Quantitative analysis showed that the percentage dose uptake of FDG in patients with a CD36 deficiency was significantly higher than that in normal controls (1.28+/-0.35 versus 0.43+/-0.22; P< 0.01). CONCLUSION: CD36 functions as a major myocardial LFA transporter and its absence may cause a compensatory upregulation of myocardial glucose uptake.  (+info)

Parametric mapping of cerebral blood flow deficits in Alzheimer's disease: a SPECT study using HMPAO and image standardization technique. (5/6785)

This study assessed the accuracy and reliability of Automated Image Registration (AIR) for standardization of brain SPECT images of patients with Alzheimer's disease (AD). Standardized cerebral blood flow (CBF) images of patients with AD and control subjects were then used for group comparison and covariance analyses. METHODS: Thirteen patients with AD at an early stage (age 69.8+/-7.1 y, Clinical Dementia Rating Score 0.5-1.0, Mini-Mental State Examination score 19-23) and 20 age-matched normal subjects (age 69.5+/-8.3 y) participated in this study. 99mTc-hexamethyl propylenamine oxime (HMPAO) brain SPECT and CT scans were acquired for each subject. SPECT images were transformed to a standard size and shape with the help of AIR. Accuracy of AIR for spatial normalization was evaluated by an index calculated on SPECT images. Anatomical variability of standardized target images was evaluated by measurements on corresponding CT scans, spatially normalized using transformations established by the SPECT images. Realigned brain SPECT images of patients and controls were used for group comparison with the help of statistical parameter mapping. Significant differences were displayed on the respective voxel to generate three-dimensional Z maps. CT scans of individual subjects were evaluated by a computer program for brain atrophy. Voxel-based covariance analysis was performed on standardized images with ages and atrophy indices as independent variables. RESULTS: Inaccuracy assessed by functional data was 2.3%. The maximum anatomical variability was 4.9 mm after standardization. Z maps showed significantly decreased regional CBF (rCBF) in the frontal, parietal and temporal regions in the patient group (P < 0.001). Covariance analysis revealed that the effects of aging on rCBF were more pronounced compared with atrophy, especially in intact cortical areas at an early stage of AD. Decrease in rCBF was partly due to senility and atrophy, however these two factors cannot explain all the deficits. CONCLUSION: AIR can transform SPECT images of AD patients with acceptable accuracy without any need for corresponding structural images. The frontal regions of the brain, in addition to parietal and temporal lobes, may show reduced CBF in patients with AD even at an early stage of dementia. The reduced rCBF in the cortical regions cannot be explained entirely by advanced atrophy and fast aging process.  (+info)

Detection of liver metastases from pancreatic cancer using FDG PET. (6/6785)

We evaluated the potential of the glucose analog [18F]fluorodeoxyglucose (FDG) as a PET tracer for the hepatic staging in 168 patients designated for resective pancreatic surgery. METHODS: Metastatic liver disease was confirmed or excluded during surgery or with CT follow-up for at least 6 mo. Proven metastases were then retrospectively identified on preoperative CT (gold standard). Hepatic PET scans of all patients were interpreted blindly. Any focal FDG uptake was considered malignant. Both proven hepatic metastases and suspicious hepatic PET lesions were then compared, lesion by lesion, with CT. Standardized uptake values (SUV) and tumor-to-liver ratios (T/L) were determined for the most intense lesion of each patient. RESULTS: Sensitivity of FDG PET was 68% (15 of 22 patients). The lesion detection rate was 97% (28 of 29 metastases) for lesions >1 cm and 43% (16 of 37 metastases) for lesions < or = 1 cm. Specificity was 95% (138 of 146 patients). Six of eight patients with false-positive results had marked intrahepatic cholestasis (versus 3 of 15 patients with true-positive lesions), one had an infrahepatic abscess and one had a right basal pulmonary metastasis. The SUV and T/L were 4.6+/-1.4 and 2.3+/-1.1, respectively, for malignant lesions and 4.1+/-1.5 and 1.9+/-0.3, respectively, for false-positive lesions and therefore are of limited value. CONCLUSION: FDG PET provides reliable hepatic staging for lesions >1 cm. False-positive results are associated with the presence of marked intrahepatic cholestasis. For lesions < or = 1 cm, FDG PET can define malignancy in 43% of suspicious CT lesions in the absence of dilated bile ducts.  (+info)

L-[1-11C]-tyrosine PET to evaluate response to hyperthermic isolated limb perfusion for locally advanced soft-tissue sarcoma and skin cancer. (7/6785)

PET with L-[1-11C]-tyrosine (TYR) was investigated in patients undergoing hyperthermic isolated limb perfusion (HILP) with recombinant tumor necrosis factor alpha (rTNF-alpha) and melphalan for locally advanced soft-tissue sarcoma and skin cancer of the lower limb. METHODS: Seventeen patients (5 women, 12 men; age range 24-75 y; mean age 52 y) were studied. TYR PET studies were performed before HILP and 2 and 8 wk afterwards. The protein synthesis rates (PSRs) in nanomoles per milliliter per minute were calculated. After final PET studies, tumors were resected and pathologically examined. Patients with pathologically complete responses (pCR) showed no viable tumors after treatment. Those with pathologically partial responses (pPR) showed various amounts of viable tumors in the resected tumor specimens. RESULTS: Six patients (35%) showed a pCR and 11 patients (65%) showed a pPR. All tumors were depicted as hot spots on PET studies before HILP. The PSR in the pCR group at 2 and 8 wk after perfusion had decreased significantly (P < 0.05) in comparison to the PSR before HILP. A significant difference was found in PSR between the pCR and pPR groups at 2 and at 8 wk (P < 0.05). Median PSR in nonviable tumor tissue was 0.62 and ranged from 0.22 to 0.91. With a threshold PSR of 0.91, sensitivity and specificity of TYR PET were 82% and 100%, respectively. The predictive value of a PSR > 0.91 for having viable tumor after HILP was 100%, whereas the predictive value of a PSR < or = 0.91 for having nonviable tumor tissue after HILP was 75%. The 2 patients in the pPR groups with a PSR < 0.91 showed microscopic islets of tumor cells surrounded by extensive necrosis on pathological examination. CONCLUSION: Based on the calculated PSR after HILP, TYR PET gave a good indication of the pathological outcome. Inflammatory tissue after treatment did not interfere with viable tumor on the images, suggesting that it may be worthwhile to pursue TYR PET in other therapy evaluation settings.  (+info)

Segmental colonic transit after oral 67Ga-citrate in healthy subjects and those with chronic idiopathic constipation. (8/6785)

Measurement of segmental colonic transit is important in the assessment of patients with severe constipation. 111In-diethylenetriamine pentaacetic acid (DTPA) has been established as the tracer of choice for these studies, but it is expensive and not readily available. 67Ga-citrate is an inexpensive tracer and when given orally is not absorbed from the bowel. It was compared with 111In-DTPA in colonic transit studies in nonconstipated control subjects and then in patients with idiopathic constipation. METHODS: Studies were performed after oral administration of 3 MBq (81 microCi) 67Ga-citrate or 4 MBq (108 microCi) 111In-DTPA in solution. Serial abdominal images were performed up to 96 h postinjection, and computer data were generated from geometric mean images of segmental retention of tracer, mean activity profiles and a colonic tracer half-clearance time. RESULTS: There were no differences in segmental retention of either tracer or in mean activity profiles between control subjects and constipated patients. Results in constipated subjects were significantly different from those in controls. The mean half-clearance times of tracer for control subjects were 28.8 h for 67Ga-citrate and 29.9 h for 111In-DTPA in control subjects and 75.0 h for 67Ga-citrate and 70.8 h for 111In-DTPA in constipated patients. CONCLUSION: Oral 67Ga-citrate can be used as a safe alternative to 111In-DTPA for accurate measurement of segmental colonic transit.  (+info)

Radiopharmaceuticals are the formulations containing radioactive substances called as radioisotopes or radiotracers. Radiopharmaceuticals are intended to a
Treatment of multisite, sclerotic bone metastases is successfully performed by radionuclide therapy. Pain palliation is the most common aim for the treatment. Two radiopharmaceuticals are currently approved by the European Medicines Agency (153Sm-EDTMP and 89Sr-Cl2) whilst other radiopharmaceuticals are at different stages of development, or are approved in some European countries (186Re-HEDP, 117Snm-DTPA and 223Ra-Cl2). The tissues at risk for the treatment are bone marrow and normal bone. A review of the methods applied for dosimetry for these tissues and for tumours is performed, including the calculation of S values (the absorbed dose per decay) and optimal procedures on how to obtain biodistribution data for each radiopharmaceutical. The dosimetry data can be used to individualise and further improve the treatment for each patient. Dosimetry for radionuclide therapy of bone metastases is feasible and can be performed in a routine clinical practice.. ...
This book is a concise guide to PET (PET/CT and PET/MRI) molecular imaging, highlighting the crucial role of novel PET radiopharmaceuticals in the clinical usefulness of PET and presenting clinical cases with multi-tracer evaluation in a single patient, revealing mismatches or diagnostic overlap.
The use of new radiopharmaceuticals can provide extremely valuable information in the evaluation of cancer, as well as heart and brain diseases - information that often times cannot be obtained by other means. However, there is a perceived need in many Member States for a useful reference to facilitate and expedite the introduction of radiopharmaceuticals already in clinical use in other countries. This publication intends to provide practical support for the introduction of new radiotracers, including recommendations on the necessary steps needed to facilitate and expedite the introduction of radiopharmaceuticals in clinical use, while ensuring that a safe and high quality product is administered to the patient at all times.. ...
Dr. A.K. Mishra, Sc. F has associated with Chemical Biology Letters as new editor for radiopharmaceuticals section. Dr. Mishra is deputy director and scientist F at the Institute of Nuclear Medicine and Allied Science (DRDO), Delhi and has big research group working on peptide radiopharmaceuticals, new radiometal discovery for PET (Positron Emission Tomography), nuclear chemistry, contrast agent development for SPECT and clinical applications of radiopharmaceuticals. He has published more than 250 research articles. His research interests are Radiopharmaceuticals, PET, Radiodiagnosis, Medicinal Chemistry, Peptide Radiopharmaceuticals, cancer diagnosis, clincal PET, Nanopharmaceuticals ...
Radiopharmaceuticals are radioisotopes bound to biological molecules able to target specific organs, tissues or cells within the human body. These radioactive drugs can be used for the diagnosis and, increasingly, for the therapy of diseases.
Radiopharmaceuticals are drugs that are bound to radioactive substances. The pharmaceutically active portion determines the activity that will be measured and the radioactive portion emits radiation that can be measured by the scanner. A number...
This recently added report entitled Global Radiopharmaceuticals/Nuclear Market envelopes all-in information of the market, statistical analysis, and perspective on the market. The study report is a detailed analysis of the market province that provides details such as industry tactics, different technologies, key companies, growth rate, business competitors, and forecast by 2025. The report highlights the historical data of the market, providing an understanding of the global Radiopharmaceuticals/Nuclear market trends, industry product innovations, and the value/volume of size, market segments, and market share of the best actors/products. It shows sufficient information about the various segments of the market.. NOTE: Our analysts monitoring the situation across the globe explains that the market will generate remunerative prospects for producers post COVID-19 crisis. The report aims to provide an additional illustration of the latest scenario, economic slowdown, and COVID-19 impact on the ...
Contrive Datum Insights has published a newly innovative statistical data, titled as Radiopharmaceuticals Market. It is a valuable source of statistical data for Radiopharmaceuticals market and includes accurate information, which uses primary and secondary research techniques. The research analyst provides comprehensive data, which enhances the growth of the industries. This report focuses on the basic requirement strategies of the businesses, which helps to enlarge the productivity. Additionally, it offers different market segments, such as application, types, size, end users, cost etc.. Get Sample Copy (Including FULL TOC, Graphs and Tables) of this report @: https://www.contrivedatuminsights.com/request-sample/44196. It includes the research studies about the current trends in different sectors on the basis of their scope. The analyst of this report focuses on the static and dynamic pillars of the industries, for basic understanding of the strategies. In addition to this, it identifies the ...
The evolution of radiopharmaceuticals. Fusion Pharma is using targeted alpha therapeutics to improve the safety of radiopharmaceuticals.
Global Radiopharmaceutical market, which was estimated at 4.32 (USD Billion) in 2015 and is predicted to accrue earnings worth 7.13 (USD Billion) by 2021, is set to record a CAGR of nearly 8.8% over 2016-2021.
Medical Mnemonics - Thyroid: Increased Radiotracer Uptake Causes - Medicine Mnemonics - Looking for a MKSAP alternative? Try the Knowmedge ABIM Internal Medicine Qbank.
MarShield was contacted by a radiopharmaceutical developer The Center for Probe Development and Commercialization (CPDC) to develop and build a series of custom radiation barriers that would be used to shield individuals from the dose radiating from freezer units used to store radioactive pharmaceutical products. Radiopharmaceuticals are a special class of drugs. They include diagnostic […]
The single most important tool for the development of high specific activity or no-carrier-added (nca) radiopharmaceuticals is a radio-HPLC. The reason for making such a strong statement in favor of...
Radiopharmacology Radiopharmacology is the study and preparation of radiopharmaceuticals, which are radioactive pharmaceuticals. Radiopharmaceuticals are used
This channel includes news and new technology innovations for nuclear and molecular imaging agents, radiotracers and radiopharmaceuticals used in PET or SPECT imaging. This includes advances in myocardiac perfusion agents.
This channel includes news and new technology innovations for nuclear and molecular imaging agents, radiotracers and radiopharmaceuticals used in PET or SPECT imaging. This includes advances in myocardiac perfusion agents.
List of equipmentManipulation description SPECT - Carefully organised system minimising unshielded manipulations with radiopharmaceuticals. The acti...
The global radiopharmaceuticals market is segmented on the basis of product type, application and geography. On the basis on product type the market is segmented into diagnostic and therapeutic products. Diagnostic products market is further classified into SPECT and PET isotopes. Therapeutics market segment is further classified alpha emitters, beta emitters, and brachytherapy. On the basis of application market is segmented into cardiology, neurology, oncology, thyroid, bone metastasis, and endocrine tumors. Geographic breakdown and deep analysis of each of the aforesaid segments is included for North America, Europe, Asia-Pacific, and rest of the world (RoW ...
NIH/HHMI/Wellcome trust policies - The established journal with over 30 years of peer-reviewed papers on new and innovative investigations of methods to improve cancer therapy. The Journal focuses on advancements in radioimmunotherapy and radiopharmaceuticals.
The established journal with over 30 years of peer-reviewed papers on new and innovative investigations of methods to improve cancer therapy. The Journal focuses on advancements in radioimmunotherapy and radiopharmaceuticals.
Some of the key developments of the market for example agreements between different kinds of manufacturing and commercialisation based companies are coming up with several kinds of advantages for the key players so that they can establish themselves as the industry leaders in this particular area. Different kinds of opportunities are being prevalent in the whole industry so that proper expansion into the market can be carried out and everybody will be contributing towards the growth of the radiopharmaceuticals market in the forecasted period very easily and efficiently. There are several kinds of companies which are depending upon the data triangulation in this whole area so that there is no issue and data mining has been perfectly carried out along with a thorough analysis of the whole thing. These kinds of data model help in ensuring that all the standards of the industry will be perfectly followed and there wont be any kind of issue for the organisations in the whole sector. In this way, the ...
Coquí RadioPharmaceuticals announced that it met an agreement with the University of Florida Foundation to acquire 25 acres of land to build a medical isotope facility.
Coquí Pharma is making its presence known in the radiopharmaceuticals industry, creating a scalable and reliable domestic supply of Mo-99 to ensure that patients have access to the low-cost diagnostics and treatments they need, when they need them.
The global market size of Radiopharmaceuticals in Nuclear Medical is $XX million in 2017 with XX CAGR from 2013 to 2017, and it is expected to reach $XX million by the end of 2023 with a CAGR of XX% from 2018 to 2023 ...
The Global Radiopharmaceuticals Market is expected to reach USD 9.49 billion by 2024 from USD 4.87 billion in 2016, at a CAGR of 8.7% in the forecast period 2017 to 2024.
Radiopharmaceutical Market 2020-2026 A New Market Study, Titled Radiopharmaceutical Market Upcoming Trends, Growth Drivers and Challenges has been featured on fusionmarketresearch. Description This global study of the Radiopharmaceutical market offers an overview of the existing market trends, drivers, restrictions, and metrics and also offers a viewpoint for important segments. The report also tracks product and services demand growth forecasts for the market. There is also to the study approach a detailed segmental review. A regional study of the global Radiopharmaceutical industry is also carried out in North America, Latin America, Asia-Pacific, Europe, and the…. Read More ...
CMIT radiopharmaceutical facilities encompass multiple laboratories that house highly technical equipment and highly trained researchers and technicians. These facilities include isotope production, radiopharmaceutical manufacturing, quality control, and research laboratories as well as the dedicated equipment such as hot cells, synthesizers and clean rooms necessary to produce high quality radiopharmaceuticals and perform high quality research. ...
Claim Adjustment Reason Codes (CARC) CO-22 or PR-22 This care may be covered by another payer per coordination of benefits. CO-19 This is ...
RiTradiology.com ดูแลรักษาโดยและเป็นของ น.พ.รัฐชัย แก้วลาย. โลโก้ RiTradiology.com เป็นลิขสิทธิ์ของ น.พ.รัฐชัย แก้วลาย. ข้อมูลส่วนตัวของคุณถือเป็นความลับและจะไม่ถูกเผยแพร่ไปยังบุคคลที่สาม. ข้อมูลใน RiTradiology.com ใช้เป็นแนวทาง, ไม่ใช่เพื่อทดแทน, การให้การวินิจฉัย, รักษาและคำแนะนำสำหรับผู้ป่วย. แพทย์ของคุณอาจให้คำแนะนำในการวินิจฉัยหรือรักษาเป็นอย่างอื่นขึ้นกับข้อมูลและสถานการณ์นั้นๆ. ...
Early buyers will receive 10% customization on reports.. This report studies the North American Nuclear Medicine/Radiopharmaceuticals market for the forecast period of 2015 to 2020. This market is expected to reach USD 2.98 Billion by 2020 from USD 1.97 Billion in 2015, at a CAGR of 8.6%.. The North American nuclear medicine/radiopharmaceuticals market is segmented on the basis of type, application, and country.. Based on type, the North American nuclear medicine/radiopharmaceuticals market is categorized into diagnostic and therapeutic radioisotopes. In 2015, the diagnostic segment accounts for a major share of the North American nuclear medicine/radiopharmaceuticals market. The large share can be attributed to increasing patient population, introduction of new and effective radioisotopes, and increase in awareness about nuclear medicine. The diagnostic radiopharmaceuticals market is further segmented into SPECT and PET radioisotopes. In 2015, the SPECT segment accounts for the largest share of ...
PET Radiopharmaceuticals for Imaging Integrin Expression: Tracers in Clinical Studies and Recent Developments. . Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.
TY - JOUR. T1 - Radiopharmaceuticals based on the glucose derivatives for tumor diagnosis. AU - Zeltchan, R. V.. AU - Medvedeva, A. A.. AU - Sinilkin, I. G.. AU - Bragina, O. V.. AU - Chernov, V. J.. PY - 2018. Y1 - 2018. N2 - The purpose of the study was to review available literature on the effcacy of radiopharmaceuticals based on glucose derivatives labeled with radioactive isotopes for detection of various cancers. material and methods. A systematic literature review was performed using the Scopus, Web of Science, MedLine, Cochrane Library, EMBASE, and Global Health databases from 2000 to 2016. Out of 900 papers in the feld of nuclear medicine, 58 were included into the review. results. 18F-fluoro-2-deoxy-D-glucose (18F-FDG) has been approved to be a powerful imaging tool for the detection of various cancers as well as for the assessment of tumor extent and therapy response. There is a continuous search for new more specifc and effective radiopharmaceuticals for visualization of tumor ...
Purpose/Introduction: Use of brain PET studies in multicentre trials or as a quantitative imaging biomarker for (automated) differential diagnosis of neurogenerative diseases require harmonized quantitative image characteristics. In this study we explored the feasibility of developing a harmonizing performance standard for brain PET studies on state of the art PET/CT systems. Subjects & Methods: In this exploratory study 6 state of the art PET/CT systems were included: Philips Gemini TF, Ingenuity TF and digital Vereos systems, 2 Siemens Biograph mCTs and a GE 710. Only systems with EARL compliant (calibration and image quality) performances were included. A 30 min dynamic PET scan of the 3D Hoffmann brain phantom was acquired. The phantom was filled with an exact known FDG stock solution (aimed at 40 kBq/mL). Each scan was reconstructedusing various clinically relevant reconstruction settings. Depending on PET/CT system reconstruction settings were varied as follows: time of flight (TOF) ...
Red blood cells (RBCs) labeled with single-photon emitters have been clinically used for blood-pool imaging. Although some PET tracers have been introduced for blood-pool imaging, they have not yet been widely used. The present study investigated the feasibility of labeling RBCs with 18F-2-deoxy-2-fluoro-D-glucose (18F-FDG) for blood-pool imaging with PET. RBCs isolated from venous blood of rats were washed with glucose-free phosphate-buffered saline and labeled with 18F-FDG. To optimize labeling efficiency, the effects of glucose deprivation time and incubation (labeling) time with 18F-FDG were investigated. Post-labeling stability was assessed by calculating the release fraction of radioactivity and identifying the chemical forms of 18F in the released and intracellular components of 18F-FDG-labeled RBCs incubated in plasma. Just after intravenous injection of the optimized autologous 18F-FDG-labeled RBCs, dynamic PET scans were performed to evaluate in vivo imaging in normal rats and intraabdominal
A system and method for performing quantitative lesion analysis in molecular breast imaging (MBI) using the opposing images of a slightly compressed breast that are obtained from the dual-head gamma camera. The method uses the shape of the pixel intensity profiles through each tumor to determine tumor diameter. Also, the method uses a thickness of the compressed breast and the attenuation of gamma rays in soft tissue to determine the depth of the tumor from the collimator face of the detector head. Further still, the method uses the measured tumor diameter and measurements of counts in the tumor and background breast region to determine relative radiotracer uptake or tumor-to-background ratio (T/B ratio).
A new cyclotron and radiopharmaceutical manufacturing facility, opened by ISOLOGIC Innovative Radiopharmaceuticals Ltd. (ISOLOGIC) at Torontos Sunnybrook Health Sciences Centre, is expanding access to positron emitting radiopharmaceuticals (PERs), an essential component in molecular imaging commonly referred to as PET imaging.. PET imaging is widely used in other Canadian provinces and worldwide in the diagnosis of cancer, cardiac, and neurological diseases.. PET scans are increasingly revolutionizing the early diagnosis of many diseases including heart disease and cancer, said Andre Gagnon, President of ISOLOGIC. In Canada, over 43,000 patients are administered PET scans every year and this type of imaging is rapidly expanding here and internationally, ISOLOGICs Toronto-based facility immediately establishes the supply of these short-lived medical isotopes necessary to promote and grow the accessibility of PET imaging in the Greater Toronto Area and throughout Ontario. To date, ...
Dublin, Nov. 4, 2013-- Research and Markets has announced the addition of the European Nuclear Medicine/Radiopharmaceuticals& Stable Isotopes Market- Trends& Forecast to 2017 report to their offering. The European radioisotopes market was valued at $1.1 billion in 2012 and is poised to reach $1.6 billion in 2017 at a CAGR of 6.8%. A study conducted by Organization for Economic Co-operation and Development estimates that Tc-99m diagnostic procedures are expected to increase by 15% to 20% in mature markets such as Europe, and other developed regions between 2010 and 2030. Radiopharmaceuticals in neurological applications such as Alzheimers disease, Parkinsons disease, and dementia are also being preferred by practitioners besides conventional treatment.
... DUBLIN August 2 2013 /- ...Research and Markets (a href http://www.researchandmarkets.com/resea... (Logo: http://photos.prnewswire.com/prnh/2013...Radiopharmaceuticals imply the usage of radiation for non-invasive tre...,Radiopharmaceuticals,Market,-,Global,Industry,Analysis,,Size,,Share,,Trends,And,Forecast,,2012,-,2018,medicine,advanced medical technology,medical laboratory technology,medical device technology,latest medical technology,Health
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Combination contrast media, imaging agents, and radiopharmaceuticals - Radiopharmaceuticals and contrast media - Drugs and Pharmaceutical Products
The following table lists the radiopharmaceuticals that are produced on routine basis. Name of the radiopharmaceuticalStatusApplication[18F] Fludeoxyglucose Injection ([18F] FDG)ANDARoutine diagnostic scans[11C] AcetateINDCardiac, cancer metabolism[18F] Fluorothymidine ([18F]FLT)INDCancer; cell proliferation[3H] CholesterolIND[18F] ISO-1INDCancer; cell proliferation[18F] Fluortriopride ([18F] FTP)INDD3 specific brain agent[18F] Fluoroestradiol ([18F] FES)INDCancer; estrogen status[18F] FluorThanatrace ([18
The study is carried out in order to investigate if [11C]AZD2995, compared to [11C]AZD2184, is a more suitable PET ligand for in vivo imaging of β amyloid depositions in the human brain. In the study the two PET ligands will be examined in both healthy volunteers and patients with Alzheimers Disease ...
[180 Pages Report] North American Nuclear Medicine/Radiopharmaceuticals Market categories the Global Market by Application (Cardiology, Oncology), Type (Therapeutic (Alpha Emitters, Beta Emitters - I-131, Brachytherapy - Y-90), Diagnostic (PET- F-18, SPECT - Technetium)) & Geography
[A case of caseous pneumonia demonstrating intense uptake on FDG-PET].: A 79-year-old man was hospitalized because of a chest X-ray abnormality. The chest X-ray
Since then, many radiopharmaceutical practices have changed, especially with the introduction of new radiotracers. This years Technologists Guide includes the basics, starting from history of radiopharmaceuticals, and proceeds to the high-end radiopharmaceuticals used in translational medicine. Illustrations and tables have been included to facilitate the understanding of certain principles. The most widely used radiopharmaceuticals in SPECT and PET have been dealt with separately because of the breadth of development since the previous publication in 2008. This years Technologists Guide also covers radiopharmaceuticals used in therapy. Authors from different backgrounds have contributed to the Guide, ensuring that it will be an important addition to the knowledge base required to perform radiopharmacy. It is an unmissable collection of information that will prove an essential aid in the clinical setting and will keep the technologist up to date with the latest radiopharmacy principles and ...
European Symposium on Radiopharmacy and Radiopharmaceuticals will be hosted in Groningen that with its active Nuclear Medicine Dept. is the ideal location.
Nuclear Medicine serves useful information to diagnose diseases in the body including heart, bone, gastrointestinal tract, brain, endocrine systems based on the function of the organs using radiopharmaceuticals. Many cases of myocardial SPECT, brain perfusion SPECT, whole body FDG PET/CT, brain FDG PET/CT and brain FP-CIT PET/CT are performed in our department. ...
TY - JOUR. T1 - Basic and practical concepts of radiopharmaceutical purification methods. AU - Molavipordanjani, Sajjad. AU - Tolmachev, Vladimir. AU - Hosseinimehr, Seyed Jalal. N1 - Publisher Copyright: © 2018 Elsevier Ltd Copyright: Copyright 2019 Elsevier B.V., All rights reserved.. PY - 2019/1. Y1 - 2019/1. N2 - The presence of radiochemical impurities in a radiopharmaceutical contributes to an unnecessary radiation burden for the patients or to an undesirable high radioactivity background, which reduces the imaging contrast or therapeutic efficacy. Therefore, if the radiolabeling process results in unsatisfactory radiochemical purity, a purification step is unavoidable. A successful purification process requires a profound knowledge about the radiopharmaceuticals of interest ranging from structural features to susceptibility to different conditions. Most radiopharmaceutical purification methods are based on solid-phase extraction (SPE), high-performance liquid chromatography (HPLC), size ...
Rationale and Objectives: To evaluate the sensitivity of high-resolution breast-specific gamma imaging (BSGI) for the detection of ductal carcinoma in situ (DCIS) based on histopathology and to compare the sensitivity of BSGI with mammography and magnetic resonance imaging (MRI) for the detection of DCIS. Materials and Methods: Twenty women, mean 55 years (range 34-76 years), with 22 biopsy-proven DCIS were retrospectively reviewed. After injection of 25-30 mCi (925-1,110 MBq) technetium 99m-sestamibi, patients had BSGI with a high-resolution, small-field-of-view gamma camera in craniocaudal and mediolateral oblique projections. BSGI studies were prospectively classified according to focal radiotracer uptake using a 1 to 5 scale, as normal 1), with no focal or diffuse uptake; benign 2), with minimal patchy uptake; probably benign 3), with scattered patchy uptake; probably abnormal 4), with mild focal radiotracer uptake; and abnormal 5), with marked focal radiotracer uptake. Imaging findings were
The Center for Molecular Imaging and Therapy (CMIT) aims to create, test and develop novel radiopharmaceuticals for molecular imaging and therapy. Were working with radiopharmaceuticals used to diagnose and treat an array of conditions like dementia, movement disorders, and many different types of cancer. We routinely produce radiopharmaceuticals manufactured under ANDAs and INDs from our own intellectual property to public-domain and proprietary radiopharmaceuticals for diagnostic and therapeutic uses. ...
A Radiopharmaceutical is a drug that can be used either for diagnostic or therapeutic purposes. It is composed of a radioisotope bond to an organic molecule. The organic molecule conveys the radioisotope to specific organs, tissues or cells. The radioisotope is selected for its properties. The global radiopharmaceuticals market was worth US$3.8 billion in 2011 and is expected to be growing at a stupendous CAGR of 18.3% to reach a value of US$12.2 billion by 2018.. ...
1. Most radiopharmaceuticals that have their own code include in the codes description per study dose and include a range of mCis (millicurie). These radiopharmaceutical agents should be billed as one unit of service per study. It is not appropriate to bill per mCi for the codes that include per study dose in its HCPCs description. It would be unusual to have more than 2 units of service for most of the agents with a per study dose or per treatment in its description ...
BV Cyclotron VU is a global specialty health science company, based in Amserdam, the Neterlands. We provide market-leading radiopharmaceuticals and radiochemicals used for research, diagnosis and treatment of disease.
PET imaging using multiple tracers is expected to provide more complementary information than a single PET study using a single tracer and thus might improve tumor diagnosis and therapeutic monitoring. Multiple, separate single-tracer studies to achieve this would be more costly and require longer total scan times, and-because of the delay between scans-wouldnt provide information under quasiconsistent physiologic conditions.. The fixed-energy γ ray of positron emitters from the positron-electron annihilation, however, presents significant challenges for imaging multiple tracers simultaneously with 1 PET scan. Since the 1980s, several methods have been developed to separate the superimposed PET signals of multiple-tracer scans (16,28). For example, Koeppe et al. (16) performed computer simulations and human PET studies using pairs of 11C-labeled tracers in a single scan to image different neurotransmitter-neuroreceptor systems and demonstrated the feasibility of parameter estimation with ...
Read about radiopharmaceuticals, a group of radioactive compounds used in medicine to either diagnose or treat diseases like breast cancer.
Current Radiopharmaceuticals Journal publishes original research articles, letters, reviews, drug clinical trial studies and guest edited issues on all aspects of research and development of radiolabelled compound preparations.
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The fields of molecular biology, immunology and genetics have generated many important developments that advance the understanding of the induction and progression of oncological, cardiological and neurological diseases as well as the identification of disease-associated molecules and drugs that specifically target diseased cells during therapy. These insights have triggered the development of targeted radiopharmaceuticals which open up a new dimension of radiopharmaceutical sciences in nuclear medicine. Radiopharmaceuticals, also called radiotracers, are radiolabelled molecules, bearing a
APAC Radiopharmaceuticals market was valued at USD 1.1 billion in 2015 and is expected to witness a CAGR of 10.9% over the forecast period.
in Cancer Research (2010), 70(22), 9022-30. Due to the high mortality of lung cancer, there is a critical need to develop diagnostic procedures enabling early detection of the disease while at a curable stage. Targeted molecular imaging builds on ... [more ▼]. Due to the high mortality of lung cancer, there is a critical need to develop diagnostic procedures enabling early detection of the disease while at a curable stage. Targeted molecular imaging builds on the positive attributes of positron emission tomography/computed tomography (PET/CT) to allow for a noninvasive detection and characterization of smaller lung nodules, thus increasing the chances of positive treatment outcome. In this study, we investigate the ability to characterize lung tumors that spontaneously arise in a transgenic mouse model. The tumors are first identified with small animal CT followed by characterization with the use of small animal PET with a novel 64Cu-1,4,7,10-tetra-azacylododecane-N,N,N,N-tetraacetic ...
Our specialty is therapeutic radiopharmaceuticals. IsoTherapeutics has set up a series of competencies for the purpose of aiding our customers/collaborators in the development of pharmaceuticals. The scientific staff at IsoTherapeutics has extensive experience in the development of radiopharmaceuticals, particularly bone-seeking radiopharmaceuticals. Additionally, we have experience designing antibody conjugates for radioimmunotherapy.. Our model is to house the necessary capabilities under one roof to shorten the development time for drug candidates.. ...
EMRAN A. Ed. New Trends in Radiopharmaceutical Synthesis, Quality Assurance and Regulatory Control, 1991 被引用文献1件 ...
Anyone else having a second scan at 9 weeks??: Im booked in for my second scan next Friday so ill be 9.3 weeks. Cant wait to see bubby again, (last time was 6.6 weeks) and make sure everything is still progressing okay, also love how they look at 9-10 weeks super cute! FC bubs has been growing perfectly am feeling confident but still anxious. Anyone else getting to ...
The Global Radiopharmaceutical market accounted for $3.76 billion in 2019 and is expected to reach $5.99 billion by 2027 growing at a CAGR of 6.0% during the forecast period. Some of the key factors propelling market growth are technological advancements in the diagnostics sector, increasing prevalence of cancer, and increasing applications of molecular imaging. However, the short half-life of…
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Cookies enable us to provide the best experience possible and help us understand how visitors use our website. By browsing cyclotron.nl you agree to use cookies. ...
Well, I had one of those long deep heart-to-heart meetings with my chemo oncologist yesterday to review Mondays CT/PET scan results and try and come up with a new strategy. The GOOD news of the scan is that the cancer hasnt invaded any new organs. The bad news is that my liver mets have really taken off in the last 2 months and it looks like at least half of my liver is involved now. It was hard to look at the scan pictures as we scrolled through, with the scan from 2 months ago, side-by-side, and see how much my cancer has grown in just 2 months even though I was on Avastin/Cytoxin all that time. We reviewed the chemo drugs I havent had yet. Most of the approved endometrial cancer drugs left to me are older ones that they dont use unless they have to because they are too harsh or less effective; and the rest of my targeted inhibitor options are all super new and reletively unproven for uterine cancer. And we frankly agreed that my cancer appears to be completely chemo resistant. I made it ...
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Does 123-I IMPY demonstrate qualitatively increased radiotracer uptake in cortical regions consistent with β-amyloid deposition in AD patients relative to ...
Researchers thus far have to use tissue obtained posthumously to diagnose the degenerative brain disease that has bedeviled those who have sustained repeated hits to the head.
[ATTACH] [ATTACH] Hi everyone, I received my Pet scan results yesterday and the report state : The exam show several mild hypoperfusion areas -...
Like you, thousands of our customers around the world rely on advanced imaging techniques to study dynamic biological process within living animals. To better understand the progression and treatment of diseases, you can use Albiras PET, SPECT and CT imaging for quantitative 3D tomographic imaging of radiotracers, bone, and soft tissue. Below are just a few of the applications of the Albira system that can provide deep insight into the underlying mechanisms of diseases and the effectiveness of new therapeutics:. ...
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The preparation and packaging of the complete radiopharmaceutical.. Radionuclides used in radiopharmaceuticals are mostly ... See also: Radiopharmaceutical. Radiopharmacology or medicinal radiochemistry is radiochemistry applied to medicine and thus the ... Drug nomenclature for radiopharmaceuticals[edit]. As with other pharmaceutical drugs, there is standardization of the drug ... Production of a radiopharmaceutical involves two processes:. *The production of the radionuclide on which the pharmaceutical is ...
Labelled OIH has a significantly higher clearance than other radiopharmaceutical yet developed and is eminently suitable for ... Testa HJ (22 October 2013). "Radiopharmaceuticals". In O'Reilly PH, Shields RA, Testa HJ (eds.). Nuclear Medicine in Urology ... and for many years this was the only radiopharmaceutical for renography. 131I has a half-life of 8 days and emits high-energy γ ...
Volkert, Wynn A.; Timothy J. Hoffman (1999). "Therapeutic Radiopharmaceuticals". Chemical Reviews. 99 (9): 2269-2292. doi: ... "68Ga-labeled DOTA-Peptides and 68Ga-labeled Radiopharmaceuticals for Positron Emission Tomography: Current Status of Research, ...
Current Radiopharmaceuticals. 9 (2): 114-120. doi:10.2174/1874471009999160625105340. PMID 27593254. Mariani, Giuliano; Giuliano ... locate the draining lymph nodes or sentinel lymph node from a breast cancer tumour a Technetium-99m based radiopharmaceutical ...
Haddad, Ferid; Barbet, Jacques; Chatal, Jean-Francois (1 July 2011). "The ARRONAX Project". Current Radiopharmaceuticals. 4 (3 ... appropriate radionuclides can be chemically bound to a targeting biomolecule which carries the combined radiopharmaceutical to ...
Volkert, Wynn A.; Hoffman, Timothy J. (1999). "Therapeutic Radiopharmaceuticals". Chemical Reviews. 99 (9): 2269-2292. doi: ... "Bone-targeting radiopharmaceuticals for the treatment of prostate cancer with bone metastases". Cancer Letters. 323 (2): 135- ... chemical and biological properties of the radiopharmaceutical to target areas of the body for radiation treatment. The related ... uses radioactive substances called radiopharmaceuticals to treat medical conditions, particularly cancer. These are introduced ...
2017 Analytical control of radiopharmaceuticals, IAEA, Vienna (1970) Radioisotopes Production and Quality Control, STI/PUB/10/ ... Surat Chairperson of Radiopharmaceuticals Committee RPC from its inception in 1967 to 1987 Dr. Iya played a key role in the ... radio-pharmaceuticals; industrial applications of radiation and radio-tracers; radiation processing of materials and medical ... 128, IAEA, Vienna (1971) Radiopharmaceuticals from generator produced radionuclides, STI/PUB/294, IAEA, Vienna (1971) ...
Robertson, A. K. H.; Ramogida, C. F.; Schaffer, P.; Radchenko, V. (2018). "Development of 225Ac radiopharmaceuticals: TRIUMF ... clinical trials have demonstrated the applicability of radiopharmaceuticals containing 225Ac to treat various types of cancer. ... perspectives and experiences". Current Radiopharmaceuticals. 11 (3): 156-172. doi:10.2174/1874471011666180416161908. PMC ...
Current Radiopharmaceuticals, 3, 68-80. 20.) Ido T, Wan CN, Casella V, Fowler JS, Wolf AP, Reivich M, and Kuhl DE (1978). " ...
Current Radiopharmaceuticals. 9 (1): 19-32. doi:10.2174/1874471008666150313111633. PMID 25771368. Arnold, K.J.; Kaewuam, R.; ... Current Radiopharmaceuticals. 9 (1): 85-93. doi:10.2174/1874471008666150313112620. PMID 25771367. Carollo, A.; Papi, S.; Chinol ...
A person who is being treated for cancer by means of a radiopharmaceutical where a radioisotope is used as a drug (usually a ... Wynn, Volkert; Hoffman, Timothy (1999). "Therapeutic Radiopharmaceuticals". Chemical Reviews (Review article). ACS Publications ...
More than 50 common radiopharmaceuticals are based on technetium-99m for imaging and functional studies of the brain, heart ... Schwochau, K. Technetium: Chemistry and Radiopharmaceutical Applications; Wiley-VCH:Weinheim, Germany, 2000. Autler, S. H. ( ... Alberto, Roger (2010). "Organometallic Radiopharmaceuticals". Medicinal Organometallic Chemistry. Topics in Organometallic ... chemistry and radiopharmaceutical applications. Wiley-VCH. ISBN 978-3-527-29496-1. B.J. Wilson, ed. (1966). The radiochemical ...
Pauwels EK, Kairemo K, Erba P, Bergström K (January 2010). "Nanoparticles in cancer". Current Radiopharmaceuticals. 1 (1): 30- ...
Vaidyanathan, G.; Zalutsky, M. R. (2008). "Astatine Radiopharmaceuticals: Prospects and Problems". Current Radiopharmaceuticals ... Barbet, J.; Bourgeois, M.; Chatal, J. (2014). "Cyclotron-Based Radiopharmaceuticals for Nuclear Medicine Therapy". In R. P.; ... Guérard, F.; Gestin, J.-F.; Brechbiel, M. W. (2013). "Production of [211At]-Astatinated Radiopharmaceuticals and Applications ... Current Radiopharmaceuticals. 4 (3): 177-185. doi:10.2174/1874471011104030177. PMC 3503149. PMID 22201707. Zuckerman, J. J.; ...
Current Radiopharmaceuticals. 6 (1): 20-7. doi:10.2174/1874471011306010004. PMC 3624777. PMID 23256748. v t e v t e. ...
Radiopharmaceuticals. 18 (1): 17-26. doi:10.1089/108497803321269296. PMID 12667305. Sakamoto N, Chastain PD, Parniewski P, ...
Radiopharmaceuticals. 25 (6): 705-12. doi:10.1089/cbr.2010.0786. PMID 21204765. Anguiano-Hernandez YM, Chartier A, Huerta S ( ...
Radiopharmaceuticals. 24 (2): 155-61. doi:10.1089/cbr.2009.0627. PMC 2902227. PMID 19409036. Janeway CA, Travers P, Walport M, ...
Nuclear medicine Radiopharmaceutical Anonymous Pentetic Acid. In Dictionary of Organic Compounds, Sixth Edition; Buckingham, J ... Radiopharmaceuticals. 14 (2): 99-111. doi:10.1089/cbr.1999.14.99. PMID 10850293. Liu, Shuang (2008-09-15). "Bifunctional ...
Dillman RO (February 2011). "Cancer immunotherapy". Cancer Biotherapy & Radiopharmaceuticals. 26 (1): 1-64. doi:10.1089/cbr. ...
Radiopharmaceuticals. 17 (5): 527-533. doi:10.1089/108497802760804754. PMID 12470422. v t e. ...
Radiopharmaceuticals. 17 (6): 689-97. doi:10.1089/108497802320970307. PMID 12537673. v t e v t e. ...
Radiopharmaceuticals. 28 (7): 510-5. doi:10.1089/cbr.2013.1487. PMC 3741422. PMID 23697926. Kijanka MM, van Brussel AS, van der ...
Radiopharmaceuticals. 14 (2): 71-79. doi:10.1089/cbr.1999.14.71. PMID 10850290. Surks, Martin J (2012). "Milestones in Thyroid ...
Radiopharmaceuticals. 14 (2): 99-111. doi:10.1089/cbr.1999.14.99. PMID 10850293. v t e v t e. ...
Cancer Biotherapy & Radiopharmaceuticals. 24: 49-56 Chaudhry, M.A. (2008). Analysis of gene expression in normal and cancer ...
"Medicinal Radiopharmaceutical Chemistry of Metal Radiopharmaceuticals". COSMOS. 08 (1): 11-81. Bibcode:2012Cosmo...8...11S. doi ... Several radiopharmaceuticals allow simultaneous imaging and therapy, enabling precise dosimetric estimates to be made. For ... PRRT is not yet widely available, with various radiopharmaceuticals at different stages of clinical trials. The cost of small ... PRRT radiopharmaceuticals are constructed with three components; the radionuclide, chelator, and somatostatin analogue (peptide ...
Radiopharmaceuticals. 28 (4): 359. doi:10.1089/cbr.2012.1373. PMID 23350897. Shang Y, Ma Y, Zhou Y, Zhang H, Duan L, Chen H, et ...
In this use, the nuclide is chemically bonded to a pharmaceutical to form a positron-emitting radiopharmaceutical, and injected ... Other types of tissue selectively take up certain iodine-131-containing tissue-targeting and killing radiopharmaceutical agents ... Implications for Radiopharmaceutical Design" (PDF). Journal of Nuclear Medicine. 33 (12): 2196-201. PMID 1460515. E. Rault; et ... Radiopharmaceuticals. 22 (3): 423-430. doi:10.1089/cbr.2006.323. PMID 17651050. BV Cyclotron VU, Amsterdam, 2016, Information ...
Cancer Biotherapy and Radiopharmaceuticals. 25 (4): 375-85. doi:10.1089/cbr.2010.0812. PMID 20707716. M. B. Chadwick et al, " ...
The agency will not take action against facilities that compound a radiopharmaceutical that is essentially a copy of . . . ... Outsourcing facilities that compound radiopharmaceuticals must not compound products using a bulk drug substance unless the ... The FDA issued final guidance for outsourcing facilities on compounding and repackaging radiopharmaceuticals, along with draft ... Home » FDA Releases Guidance on Radiopharmaceutical Compounding. FDA Releases Guidance on Radiopharmaceutical Compounding. ...
Radiopharmaceuticals Production, Dr. Torsten Knieß. *GMP-certified Radiopharmaceuticals Production. *Radiotracer and ... Departments of Radiopharmaceutical Cancer Research. Radionuclide Theragnostics, Dr. Hans-Jürgen Pietzsch. *Molecular Metal ... Radiopharmaceutical and Chemical Biology, Prof. Dr. Jens Pietzsch. *Radiotracer and Drug Development ...
Radiopharmaceuticals Market, Radiopharmaceuticals Market Dynamics, Radiopharmaceuticals Market Growth, Radiopharmaceuticals ... Radiopharmaceuticals Market, Radiopharmaceuticals Market Dynamics, Radiopharmaceuticals Market Growth, Radiopharmaceuticals ... Radiopharmaceuticals New report offers analysis on the Market 2016 - 2026 A competent team of analysts at XploreMR provides ... Radiopharmaceuticals Market Estimated to Flourish at by 2016 - 2026 North America is anticipated to be the most attractive ...
They will suggest how a radiopharmaceutical could be improved and propose an investigation to validate their design. ...
... radiotracers and radiopharmaceuticals used in PET or SPECT imaging. This includes advances in myocardiac perfusion agents. ... Radiopharmaceuticals and Tracers. This channel includes news and new technology innovations for nuclear and molecular imaging ... No APCs for Nuclear Medicine, Radiopharmaceuticals in HOPPS November 4, 2009 - The Centers for Medicare and Medicaid Services ( ... September 21, 2009 - IBA (Ion Beam Applications S.A.), a provider of PET radiopharmaceuticals, and Aposense Ltd., a... ...
... radiotracers and radiopharmaceuticals used in PET or SPECT imaging. This includes advances in myocardiac perfusion agents. ... Global Trends in Radiopharmaceuticals, Therapy and PET/SPECT Imaging August 24, 2011 -- Radiopharmaceuticals are pharmaceutical ... Radiopharmaceuticals and Tracers. This channel includes news and new technology innovations for nuclear and molecular imaging ... Lantheus Awarded Supplier Agreement with Premier for Radiopharmaceutical Products October 31, 2011 -Lantheus Medical announced ...
"Innovative radiopharmaceuticals are revolutionizing the diagnosis and treatment of a wide variety of diseases, but under ... which would change the CMS policy of bundling diagnostic PET radiopharmaceuticals in hospital outpatient procedures. " ...
Avid Radiopharmaceuticals and Lighthouse Capital Partners Case Study Help Analysis With Solution Online. If you are in search ... Avid Radiopharmaceuticals and Lighthouse Capital Partners Case Study Help Analysis With Solution Online. *September 6, 2018 ... Avid Radiopharmaceuticals and Lighthouse Capital Partners Case Study Help Analysis With Solution Online. ... Looking for best Avid Radiopharmaceuticals and Lighthouse Capital Partners Case Study Help Analysis With Solution online, ...
Overall, 200 subjects will be randomized (1:1 randomization ratio) to receive standard injected activities of 177Lu-DOTATOC PRRT or personalized injection of 177Lu-DOTATOC PRRT. Randomization will be stratified for grade and primary location.. Screening Phase: Subjects will be screened against the inclusion and exclusion criteria. Screening by SSR imaging will be completed to determine expression of SSR and feasibility of treatment by PRRT. Once eligibility has been confirmed they will be randomized. Subjects will undergo a physical exam, complete a medical history questionnaire, quality of life questionnaires, blood work, and a diagnostic CT.. Treatment Phase: During the treatment phase, subjects will undergo 4 cycles of treatment. Each treatment cycle will be followed by 2 dosimetry SPECT/CT scans on day 1 (18 - 32 hours after treatment administration) and day 2 (64 - 80h after treatment administration) After cycle 3 quality of life questionnaires will be completed again.. Follow up Phase: At ...
Scientific, technical publications in the nuclear field, includes international safety standards, technical guides, conference records and scientific reports.
Radiopharmaceutical. Synthesis module for the production of radiopharmaceuticals.. Production of DMDPA radiotracer for clinical ...
Elizabeth Itotia, Kenyas First female Radiopharmaceutical Scientist. EntertainmentFashionList 10 Cute Photos Of 29 Year Dr. ... As of July in 2021, she was the only female with the qualifications of Radiopharmaceutical Scientist. Her other fellow with ... In 2021 July, she rose to the world map as Kenyas first female radiopharmaceutical scientist. ...
177Lu-Labeled Eu-Doped Mesoporous SiO2Nanoparticles as a Theranostic Radiopharmaceutical for Colorectal Cancer. In: ACS Applied ... 177Lu-Labeled Eu-Doped Mesoporous SiO2Nanoparticles as a Theranostic Radiopharmaceutical for Colorectal Cancer. ACS Applied ... 177Lu-Labeled Eu-Doped Mesoporous SiO2Nanoparticles as a Theranostic Radiopharmaceutical for Colorectal Cancer. / Viana, ... 177Lu-Labeled Eu-Doped Mesoporous SiO2Nanoparticles as a Theranostic Radiopharmaceutical for Colorectal Cancer. ...
Compounding and Repackaging of Radiopharmaceuticals By Outsourcing Facilities. NA. 8/27/2018. Federal Register Notice. List of ... Compounding and Repackaging of Radiopharmaceuticals by State-Licensed Nuclear Pharmacies and Federal Facilities. NA. ...
The first radionuclide used for bone pain is 32-P. Nowadays, radiopharmaceutical therapy of bone cancer pain is conducted with ... Metabolic Radiopharmaceutical Therapy with 89-Sr (Metastron) for Metastatic Bone Pain // Метаболитна радиофармацевтична терапия ... Metabolic Radiopharmaceutical Therapy with 89-Sr (Metastron) for Metastatic Bone Pain // Метаболитна радиофармацевтична терапия ...
Development of radionuclides for innovative radiopharmaceuticals. Using PSIs cyclotrons and spallation neutron source (SINQ), ...
Radiopharmaceuticals are carefully tested. The risk of side effects is extremely small. Most radiopharmaceuticals used in ... We will draw a small amount of blood through the IV and mix it with a radiopharmaceutical. This process takes approximately 30 ... We do the test by giving your child an intravenous radiopharmaceutical. This tracer is medicine combined with a small amount ... Your childs blood (with the radiopharmaceutical) will be administered back into the IV line. ...
Journal of Labelled Compounds and Radiopharmaceuticals, 54(S1), S299. ... Journal of Labelled Compounds and Radiopharmaceuticals, 54(S1), S299. ...
Cancer Biotherapy & Radiopharmaceuticals BB SIIC. Ingreso: 2003- Editor: Robert K. Oldham. A peer-reviewed journal on new and ... Includes more selective delivery of drugs, biologicals, radiopharmaceuticals, or other agents, and advances in delivery ...
Moadel has been with Montefiore since 2002, with a clinical focus on therapeutic radiopharmaceuticals in oncology and pediatric ...
Examples: Paints, lighter fluid, fireworks, tear gases, oxygen bottles, and radio-pharmaceuticals. There are special exceptions ...
Radioisotopes: Tools in Radiopharmaceutical Sciences. The custom production of caliber radioisotopes is key for application in ...
Among them, those from radiopharmaceutical production units remain the most likely. One of them is located in Western Russia ... radiopharmaceutical production units , sewage sludge incinerators , nuclear power plants , spontaneous fission of uranium in ...
Development of High-LET Therapeutic Radiopharmaceuticals** (INOR, MEDI). D. D. General Topics in Nuclear Chemistry. D. ...
Visit Sandoz and Advanced Accelerator Applications to learn about our generics and radiopharmaceutical products. Please note: ...
"Synthesis and evaluation of radiopharmaceuticals for targeted radionuclide therapy". Les mer ... Mastergradseksamen: Christine ...
Radiopharmaceutical medicinal product. No D.3.11.6. Immunological medicinal product (such as vaccine, allergen, immune serum). ...
Radiopharmaceutical medicinal product. No D.3.11.6. Immunological medicinal product (such as vaccine, allergen, immune serum). ... Radiopharmaceutical medicinal product. No D.3.11.6. Immunological medicinal product (such as vaccine, allergen, immune serum). ... Radiopharmaceutical medicinal product. No D.3.11.6. Immunological medicinal product (such as vaccine, allergen, immune serum). ... Radiopharmaceutical medicinal product. No D.3.11.6. Immunological medicinal product (such as vaccine, allergen, immune serum). ...
Radiopharmaceutical medicinal product. No D.3.11.6. Immunological medicinal product (such as vaccine, allergen, immune serum). ...
Radiopharmaceuticals, diagnostic use Research, development, manufacturing, sales and import / export of drugs, medical devices ...
  • Development of radionuclides for innovative radiopharmaceuticals. (psi.ch)
  • Nuclear medicine procedures use pharmaceuticals that have been labeled with radionuclides ( radiopharmaceuticals ). (wikidoc.org)
  • Created page with '=== Radiopharmaceutical chemistry === Topics: - production of radionuclides o in cyclotrons o in nuclear reactor o with radionuclide generators o radionuclidic purity o target c. (uio.no)
  • Furthermore, bone-site-specific tissue masses are required to properly estimate skeletal-averaged absorbed fractions and, more importantly, specific absorbed fractions for internalized radionuclides and radiopharmaceuticals. (elsevier.com)
  • Amyvid (florbetapir) is a molecular imaging tool under investigation for the detection of beta-amyloid plaque - the presence of which is associated with Alzheimer's disease - which Lilly acquired through its purchase of Avid Radiopharmaceuticals in December last year. (pharmatimes.com)
  • Despite the current rejection, Daniel Skovronsky, chief executive of Avid Radiopharmaceuticals, said he is "encouraged" that the Committee "recommended a clear path toward approval" for the agent. (pharmatimes.com)
  • Avid Radiopharmaceuticals is a research and development firm that develops modern molecular imaging products (Rodes-Krope and Leamon 4). (grand-essays.com)
  • SNMMI and its coalition of patient advocacy partners support The Facilitating Innovative Nuclear Diagnostics Act of 2021, which would change the CMS policy of bundling diagnostic PET radiopharmaceuticals in hospital outpatient procedures. (smartbrief.com)
  • In 2021 July, she rose to the world map as Kenya's first female radiopharmaceutical scientist. (co.ke)
  • As of July in 2021, she was the only female with the qualifications of Radiopharmaceutical Scientist. (co.ke)
  • Dr. Moadel has been with Montefiore since 2002, with a clinical focus on therapeutic radiopharmaceuticals in oncology and pediatric nuclear medicine, and a particular interest in the therapy of thyroid, liver, and prostate cancers. (montefiore.org)
  • Innovative, therapeutic, and diagnostic targeted radiopharmaceuticals filling critical gaps in oncologic care. (evathera.com)
  • English: The nuclear properties of rhenium (186/188Re) and technetium (99mTc) are used for their application as diagnostic and therapeutic radiopharmaceuticals. (ufs.ac.za)
  • This site is to give an introduction into the field and, most importantly, will emphasize recent developments and perspectives in the medical application of various radiopharmaceuticals used as tracers in diagnostics and therapy. (radiopharmazie.de)
  • Given that the nuclear industries could have an important role to play in addressing climate change as well as their ongoing role in medically important radiopharmaceuticals and diagnostics, there is a pressing need to understand the level of understanding among the public to allow the nuclear industries in Brazil to mature further. (inderscience.com)
  • As pioneers in radiopharmaceutical research, Molecular Targeting Technologies, Inc. (MTTI) strives to create radiopharmaceutical "theranostics" (therapeutics/diagnostics) that deliver tangible value in more effective treatments, more lives saved, and lower burden to health systems. (evathera.com)
  • The special field of interest of this group is the preclinical and clinical testing of new radiopharmaceuticals for nuclear medicine diagnostics of brain tumours using Positron-Emission-Tomography (PET) and correlation with Magnetic Resonance Imaging (MRI). (fz-juelich.de)
  • The diplomats visited the construction facilities of Phase 1 and 2 of the CNTRD - the Preclinical Cyclotron-Radiopharmacology Complex (PCRC) which will produce radiopharmaceuticals for diagnostics and treatment of oncology, as well as the Multipurpose Irradiation Centre (MIC) with a commercial gamma-ray unit for the treatment of medical devices and agricultural products. (neimagazine.com)
  • This channel includes news and new technology innovations for nuclear and molecular imaging agents, radiotracers and radiopharmaceuticals used in PET or SPECT imaging. (dicardiology.com)
  • Nuclear medicine imaging uses radiopharmaceuticals or radiotracers which are injected, swallowed, or inhaled depending on the test. (sinky.net)
  • In a reactor, molybdenum-98 ( Mo-98 ) is irradiated to become Mo-99 , which is then removed from the reactor and shipped to radiopharmaceutical houses all over North America . (wikidoc.org)
  • Metabolic Radiopharmaceutical Therapy with 89-Sr (Metastron) for Metastatic Bone Pain // Метаболитна радиофармацевтична терапия със 89-Sr (Metastron) при болезнени костни метастази. (mu-varna.bg)
  • The first radionuclide used for bone pain is 32-P. Nowadays, radiopharmaceutical therapy of bone cancer pain is conducted with several radiopharmeceuticals 89-Sr, 153-Sm, 186 Re. (mu-varna.bg)
  • Most radiopharmaceuticals used in nuclear medicine studies give less radiation exposure than a day at the beach. (chop.edu)
  • In 1992, the PET Center started with development, evaluation and routine production (GMP) of radiopharmaceuticals for direct clinical applications. (radiopharmazie.de)
  • Sept. 4, 2014 (GLOBE NEWSWIRE) - Cellectar Biosciences, Inc. (Nasdaq:CLRB), announced today that the U.S. Food & Drug Administration (FDA) has accepted the Company's investigational new drug (IND) application to begin clinical study of I-131-CLR1404, a highly-selective, cancer-targeting radiopharmaceutical, in patients with relapsed or refractory multiple myeloma, an incurable cancer of plasma cells. (wisbusiness.com)
  • The FDA issued final guidance for outsourcing facilities on compounding and repackaging radiopharmaceuticals, along with draft guidance on insanitary conditions at compounding facilities. (fdanews.com)
  • But radiopharmaceutical chemist Mark Goodman, PhD, kept his eye on the prize: a new and improved imaging agent to detect and view cancers. (autm.net)
  • With this data in hand, we approached Emory's Office of Technology Transfer about our discovery," says Goodman, program director for Emory's Center of Systems Imaging and director of the Radiopharmaceutical Discovery lab. (autm.net)
  • The injection material is a radiopharmaceutical that is used in imaging to "estimate the density of neuritic beta-amyloid plaques in the brains of adult patients with cognitive impairment. (hcplive.com)
  • A panel discussion focusing on how radiopharmaceutical extravasation affects the quality and quantification of nuclear medicine imaging studies. (altuslearn.com)
  • Among them, those from radiopharmaceutical production units remain the most likely. (mendeley.com)
  • Implementing a multi-functional, radioisotope and radiopharmaceutical production facility is a complex task. (advancedcyclotron.com)
  • At Advanced Cyclotron Systems, Inc. (ACSI), we work closely with our customers throughout the entire project lifecycle - starting from facility design, equipment installation, radioisotope and radiopharmaceutical production, quality assurance , and regulatory advice - to the delivery of the final radiopharmaceutical dose. (advancedcyclotron.com)
  • Given the high degree of integration between the cyclotron and radioisotope production systems, customization of hotcells, target and radioisotope delivery systems, and radiopharmacy equipment to the specific radiopharmaceutical production processes is required. (advancedcyclotron.com)
  • Corresponding study author Subramani Parasuraman explained to Pharmacy Times that, in the old days, pharmacists merely dispensed medications, but now, there is a growing need for radiopharmaceutical specialists who can contribute to the health care system. (pharmacytimes.com)
  • All investigational products (medications, devices, or radiopharmaceuticals) must be approved by the Institutional Review Board (IRB) which is a committee consisting of physicians, other professionals, and an individual from the community. (cellmedicinesociety.org)
  • Prepares and maintains records of research radiopharmaceuticals being evaluated at the University of Utah Medical Center. (utah.edu)
  • Nuclear Medicine (Radiopharmaceuticals) Market Research Report- insightSLICE The Nuclear Medicine (Radiopharmaceuticals) market study by insightSLICE offers compelling insights into key growth drivers and restraints impacting the market through 2031. (raleighnewsnow.com)
  • A series of fac-manganese(I) tricarbonyl complexes were synthesized and analysed to better understand the chemical properties of the group 7 radiopharmaceutical model complex. (ufs.ac.za)
  • Visit Sandoz and Advanced Accelerator Applications to learn about our generics and radiopharmaceutical products. (novartis.com)
  • Often, radiopharmaceuticals are dispensed from the nuclear pharmacy unit and monitored for formulation and quality controls by nuclear pharmacists. (pharmacytimes.com)
  • Responsible for the daily preparation, dispensing, ordering and quality control of radiopharmaceuticals. (utah.edu)
  • Tec-Control Chromatography tests the radiochemical purity of specific Tc-99m-labeled radiopharmaceuticals. (nuclearsupplies.co.nz)
  • However, there is also a growing need for nuclear pharmacists who can focus on providing better radiopharmaceutical care to patients. (pharmacytimes.com)
  • August 24, 2011 -- Radiopharmaceuticals are pharmaceutical agents used to diagnose certain medical problems, such as. (dicardiology.com)
  • We're passionate about advancing the future of radiopharmaceuticals through next-generation theranostic technologies. (evathera.com)
  • The joint venture contemplates turnkey manufacturing, bottling and distribution of Barium radiopharmaceuticals for MRI, X-ray and CT scan applications. (cbj.ca)
  • Journal of Labelled Compounds and Radiopharmaceuticals. (sckcen.be)
  • ImagingX plans to employ a strategy of selling competitively priced radiopharmaceuticals for MRI, X-ray and CT scan applications. (cbj.ca)
  • The use of radiopharmaceuticals for treating cancer in Europe has grown considerably over the last few years. (euramet.org)
  • But the makers of nuclear medicine equipment and radiopharmaceuticals can do a lot to help alleviate potential problems, Links said. (diagnosticimaging.com)
  • Although roughly half of the study participants knew about nuclear pharmacists (55.39%), overall awareness on the role of pharmacists in nuclear medicine was poor, and only 29.63% of respondents were aware of the use of radiopharmaceuticals in the health care system. (pharmacytimes.com)
  • Extend the blood half-life of targeting radiopharmaceuticals. (evathera.com)
  • We will draw a small amount of blood through the IV and mix it with a radiopharmaceutical. (chop.edu)
  • Your child's blood (with the radiopharmaceutical) will be administered back into the IV line. (chop.edu)
  • A Nuclear Pharmacist must be able to evaluate radiopharmaceutical (RP) drug orders to ensure the proper RP is dispensed in the proper dosage to the correct patient at the correct time. (utah.edu)
  • Nuclear medicine diagnostic tests are usually provided by a dedicated department within a hospital and may include facilities for the preparation of radiopharmaceuticals. (wikidoc.org)
  • We do the test by giving your child an intravenous radiopharmaceutical. (chop.edu)