Radiation Dosage
The amount of radiation energy that is deposited in a unit mass of material, such as tissues of plants or animal. In RADIOTHERAPY, radiation dosage is expressed in gray units (Gy). In RADIOLOGIC HEALTH, the dosage is expressed by the product of absorbed dose (Gy) and quality factor (a function of linear energy transfer), and is called radiation dose equivalent in sievert units (Sv).
Radiation, Ionizing
ELECTROMAGNETIC RADIATION or particle radiation (high energy ELEMENTARY PARTICLES) capable of directly or indirectly producing IONS in its passage through matter. The wavelengths of ionizing electromagnetic radiation are equal to or smaller than those of short (far) ultraviolet radiation and include gamma and X-rays.
Radiation Injuries
Dose-Response Relationship, Radiation
Radiation Tolerance
Radiation
Radiation Monitoring
The observation, either continuously or at intervals, of the levels of radiation in a given area, generally for the purpose of assuring that they have not exceeded prescribed amounts or, in case of radiation already present in the area, assuring that the levels have returned to those meeting acceptable safety standards.
Radiation Oncology
Cosmic Radiation
Radiation Injuries, Experimental
Radiation Pneumonitis
Neoplasms, Radiation-Induced
Gamma Rays
Penetrating, high-energy electromagnetic radiation emitted from atomic nuclei during NUCLEAR DECAY. The range of wavelengths of emitted radiation is between 0.1 - 100 pm which overlaps the shorter, more energetic hard X-RAYS wavelengths. The distinction between gamma rays and X-rays is based on their radiation source.
Background Radiation
Radiometry
Ultraviolet Rays
That portion of the electromagnetic spectrum immediately below the visible range and extending into the x-ray frequencies. The longer wavelengths (near-UV or biotic or vital rays) are necessary for the endogenous synthesis of vitamin D and are also called antirachitic rays; the shorter, ionizing wavelengths (far-UV or abiotic or extravital rays) are viricidal, bactericidal, mutagenic, and carcinogenic and are used as disinfectants.
Radiation Effects
Radiation-Sensitizing Agents
Combined Modality Therapy
Radiation-Protective Agents
Acute Radiation Syndrome
A condition caused by a brief whole body exposure to more than one sievert dose equivalent of radiation. Acute radiation syndrome is initially characterized by ANOREXIA; NAUSEA; VOMITING; but can progress to hematological, gastrointestinal, neurological, pulmonary, and other major organ dysfunction.
Radioactive Hazard Release
Cobalt Radioisotopes
Radiobiology
Radiotherapy, Conformal
X-Rays
Penetrating electromagnetic radiation emitted when the inner orbital electrons of an atom are excited and release radiant energy. X-ray wavelengths range from 1 pm to 10 nm. Hard X-rays are the higher energy, shorter wavelength X-rays. Soft x-rays or Grenz rays are less energetic and longer in wavelength. The short wavelength end of the X-ray spectrum overlaps the GAMMA RAYS wavelength range. The distinction between gamma rays and X-rays is based on their radiation source.
Radiation Hybrid Mapping
A method for ordering genetic loci along CHROMOSOMES. The method involves fusing irradiated donor cells with host cells from another species. Following cell fusion, fragments of DNA from the irradiated cells become integrated into the chromosomes of the host cells. Molecular probing of DNA obtained from the fused cells is used to determine if two or more genetic loci are located within the same fragment of donor cell DNA.
Dose Fractionation
Radiotherapy, Intensity-Modulated
Brachytherapy
DNA Damage
Injuries to DNA that introduce deviations from its normal, intact structure and which may, if left unrepaired, result in a MUTATION or a block of DNA REPLICATION. These deviations may be caused by physical or chemical agents and occur by natural or unnatural, introduced circumstances. They include the introduction of illegitimate bases during replication or by deamination or other modification of bases; the loss of a base from the DNA backbone leaving an abasic site; single-strand breaks; double strand breaks; and intrastrand (PYRIMIDINE DIMERS) or interstrand crosslinking. Damage can often be repaired (DNA REPAIR). If the damage is extensive, it can induce APOPTOSIS.
Linear Energy Transfer
Radiodermatitis
Radiotherapy Planning, Computer-Assisted
Radiotherapy, Adjuvant
Radiation Genetics
Leukemia, Radiation-Induced
Body Burden
Synchrotrons
Radiation, Nonionizing
Relative Biological Effectiveness
Electromagnetic Radiation
Particle Accelerators
Cesium Radioisotopes
Abnormalities, Radiation-Induced
Whole-Body Irradiation
Thermoluminescent Dosimetry
DNA Repair
The reconstruction of a continuous two-stranded DNA molecule without mismatch from a molecule which contained damaged regions. The major repair mechanisms are excision repair, in which defective regions in one strand are excised and resynthesized using the complementary base pairing information in the intact strand; photoreactivation repair, in which the lethal and mutagenic effects of ultraviolet light are eliminated; and post-replication repair, in which the primary lesions are not repaired, but the gaps in one daughter duplex are filled in by incorporation of portions of the other (undamaged) daughter duplex. Excision repair and post-replication repair are sometimes referred to as "dark repair" because they do not require light.
Technology, Radiologic
The application of scientific knowledge or technology to the field of radiology. The applications center mostly around x-ray or radioisotopes for diagnostic and therapeutic purposes but the technological applications of any radiation or radiologic procedure is within the scope of radiologic technology.
Radiography
Radiosurgery
A radiological stereotactic technique developed for cutting or destroying tissue by high doses of radiation in place of surgical incisions. It was originally developed for neurosurgery on structures in the brain and its use gradually spread to radiation surgery on extracranial structures as well. The usual rigid needles or probes of stereotactic surgery are replaced with beams of ionizing radiation directed toward a target so as to achieve local tissue destruction.
Brain Neoplasms
Neoplasms of the intracranial components of the central nervous system, including the cerebral hemispheres, basal ganglia, hypothalamus, thalamus, brain stem, and cerebellum. Brain neoplasms are subdivided into primary (originating from brain tissue) and secondary (i.e., metastatic) forms. Primary neoplasms are subdivided into benign and malignant forms. In general, brain tumors may also be classified by age of onset, histologic type, or presenting location in the brain.
Radioactive Fallout
Solar Activity
Tomography, X-Ray Computed
Treatment Outcome
Radiotherapy, High-Energy
Radiotherapy using high-energy (megavolt or higher) ionizing radiation. Types of radiation include gamma rays, produced by a radioisotope within a teletherapy unit; x-rays, electrons, protons, alpha particles (helium ions) and heavy charged ions, produced by particle acceleration; and neutrons and pi-mesons (pions), produced as secondary particles following bombardment of a target with a primary particle.
Chernobyl Nuclear Accident
Cell Survival
Head and Neck Neoplasms
Soft tissue tumors or cancer arising from the mucosal surfaces of the LIP; oral cavity; PHARYNX; LARYNX; and cervical esophagus. Other sites included are the NOSE and PARANASAL SINUSES; SALIVARY GLANDS; THYROID GLAND and PARATHYROID GLANDS; and MELANOMA and non-melanoma skin cancers of the head and neck. (from Holland et al., Cancer Medicine, 4th ed, p1651)
Neoplasms
Cranial Irradiation
Heavy Ions
Infrared Rays
Film Dosimetry
Radiography, Interventional
Diagnostic and therapeutic procedures that are invasive or surgical in nature, and require the expertise of a specially trained radiologist. In general, they are more invasive than diagnostic imaging but less invasive than major surgery. They often involve catheterization, fluoroscopy, or computed tomography. Some examples include percutaneous transhepatic cholangiography, percutaneous transthoracic biopsy, balloon angioplasty, and arterial embolization.
Radiotherapy, Computer-Assisted
Radioisotopes
Health Physics
Scattering, Radiation
Nuclear Reactors
Devices containing fissionable material in sufficient quantity and so arranged as to be capable of maintaining a controlled, self-sustaining NUCLEAR FISSION chain reaction. They are also known as atomic piles, atomic reactors, fission reactors, and nuclear piles, although such names are deprecated. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
Cobalt Isotopes
Neoplasm Recurrence, Local
Phantoms, Imaging
Devices or objects in various imaging techniques used to visualize or enhance visualization by simulating conditions encountered in the procedure. Phantoms are used very often in procedures employing or measuring x-irradiation or radioactive material to evaluate performance. Phantoms often have properties similar to human tissue. Water demonstrates absorbing properties similar to normal tissue, hence water-filled phantoms are used to map radiation levels. Phantoms are used also as teaching aids to simulate real conditions with x-ray or ultrasonic machines. (From Iturralde, Dictionary and Handbook of Nuclear Medicine and Clinical Imaging, 1990)
Carcinoma, Squamous Cell
Retrospective Studies
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
Radioactive Pollutants
Radiotherapy, Image-Guided
Apoptosis
One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.
Organs at Risk
Neoplasm Staging
Alpha Particles
Nuclear Medicine
Skin
Occupational Exposure
Radiation Chimera
Bystander Effect
Follow-Up Studies
Proctitis
Antineoplastic Combined Chemotherapy Protocols
Yttrium Radioisotopes
Radioimmunotherapy
Radiotherapy where cytotoxic radionuclides are linked to antibodies in order to deliver toxins directly to tumor targets. Therapy with targeted radiation rather than antibody-targeted toxins (IMMUNOTOXINS) has the advantage that adjacent tumor cells, which lack the appropriate antigenic determinants, can be destroyed by radiation cross-fire. Radioimmunotherapy is sometimes called targeted radiotherapy, but this latter term can also refer to radionuclides linked to non-immune molecules (see RADIOTHERAPY).
Amifostine
Survival Analysis
A class of statistical procedures for estimating the survival function (function of time, starting with a population 100% well at a given time and providing the percentage of the population still well at later times). The survival analysis is then used for making inferences about the effects of treatments, prognostic factors, exposures, and other covariates on the function.
Iridium Radioisotopes
Survival Rate
Glioblastoma
A malignant form of astrocytoma histologically characterized by pleomorphism of cells, nuclear atypia, microhemorrhage, and necrosis. They may arise in any region of the central nervous system, with a predilection for the cerebral hemispheres, basal ganglia, and commissural pathways. Clinical presentation most frequently occurs in the fifth or sixth decade of life with focal neurologic signs or seizures.
Ataxia Telangiectasia Mutated Proteins
A group of PROTEIN-SERINE-THREONINE KINASES which activate critical signaling cascades in double strand breaks, APOPTOSIS, and GENOTOXIC STRESS such as ionizing ultraviolet A light, thereby acting as a DNA damage sensor. These proteins play a role in a wide range of signaling mechanisms in cell cycle control.
Genetic Speciation
Glioma
Benign and malignant central nervous system neoplasms derived from glial cells (i.e., astrocytes, oligodendrocytes, and ependymocytes). Astrocytes may give rise to astrocytomas (ASTROCYTOMA) or glioblastoma multiforme (see GLIOBLASTOMA). Oligodendrocytes give rise to oligodendrogliomas (OLIGODENDROGLIOMA) and ependymocytes may undergo transformation to become EPENDYMOMA; CHOROID PLEXUS NEOPLASMS; or colloid cysts of the third ventricle. (From Escourolle et al., Manual of Basic Neuropathology, 2nd ed, p21)
Tumor Suppressor Protein p53
Cisplatin
An inorganic and water-soluble platinum complex. After undergoing hydrolysis, it reacts with DNA to produce both intra and interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity of cisplatin correlates with cellular arrest in the G2 phase of the cell cycle.
Microwaves
Radiopharmaceuticals
Radiation Leukemia Virus
Iodine Radioisotopes
Neutrons
Electrically neutral elementary particles found in all atomic nuclei except light hydrogen; the mass is equal to that of the proton and electron combined and they are unstable when isolated from the nucleus, undergoing beta decay. Slow, thermal, epithermal, and fast neutrons refer to the energy levels with which the neutrons are ejected from heavier nuclei during their decay.
Disease-Free Survival
Chemotherapy, Adjuvant
Sunscreening Agents
Deinococcus
Cell Cycle
The complex series of phenomena, occurring between the end of one CELL DIVISION and the end of the next, by which cellular material is duplicated and then divided between two daughter cells. The cell cycle includes INTERPHASE, which includes G0 PHASE; G1 PHASE; S PHASE; and G2 PHASE, and CELL DIVISION PHASE.
Lymphatic Irradiation
Mice, Nude
Mastectomy, Segmental
Neoplasms, Second Primary
Abnormal growths of tissue that follow a previous neoplasm but are not metastases of the latter. The second neoplasm may have the same or different histological type and can occur in the same or different organs as the previous neoplasm but in all cases arises from an independent oncogenic event. The development of the second neoplasm may or may not be related to the treatment for the previous neoplasm since genetic risk or predisposing factors may actually be the cause.
DNA Breaks, Double-Stranded
Tumor Cells, Cultured
Photons
Erythema
Astronauts
Prognosis
Positron-Emission Tomography
An imaging technique using compounds labelled with short-lived positron-emitting radionuclides (such as carbon-11, nitrogen-13, oxygen-15 and fluorine-18) to measure cell metabolism. It has been useful in study of soft tissues such as CANCER; CARDIOVASCULAR SYSTEM; and brain. SINGLE-PHOTON EMISSION-COMPUTED TOMOGRAPHY is closely related to positron emission tomography, but uses isotopes with longer half-lives and resolution is lower.
Biological Evolution
Radiology, Interventional
Tumor Burden
Hodgkin Disease
A malignant disease characterized by progressive enlargement of the lymph nodes, spleen, and general lymphoid tissue. In the classical variant, giant usually multinucleate Hodgkin's and REED-STERNBERG CELLS are present; in the nodular lymphocyte predominant variant, lymphocytic and histiocytic cells are seen.
Risk Assessment
Elasticity Imaging Techniques
Non-invasive imaging methods based on the mechanical response of an object to a vibrational or impulsive force. It is used for determining the viscoelastic properties of tissue, and thereby differentiating soft from hard inclusions in tissue such as microcalcifications, and some cancer lesions. Most techniques use ultrasound to create the images - eliciting the response with an ultrasonic radiation force and/or recording displacements of the tissue by Doppler ultrasonography.
Fossils
Reproducibility of Results
The statistical reproducibility of measurements (often in a clinical context), including the testing of instrumentation or techniques to obtain reproducible results. The concept includes reproducibility of physiological measurements, which may be used to develop rules to assess probability or prognosis, or response to a stimulus; reproducibility of occurrence of a condition; and reproducibility of experimental results.
Environmental Exposure
Radiographic Image Enhancement
Actuarial Analysis
The application of probability and statistical methods to calculate the risk of occurrence of any event, such as onset of illness, recurrent disease, hospitalization, disability, or death. It may include calculation of the anticipated money costs of such events and of the premiums necessary to provide for payment of such costs.
Ataxia Telangiectasia
An autosomal recessive inherited disorder characterized by choreoathetosis beginning in childhood, progressive CEREBELLAR ATAXIA; TELANGIECTASIS of CONJUNCTIVA and SKIN; DYSARTHRIA; B- and T-cell immunodeficiency, and RADIOSENSITIVITY to IONIZING RADIATION. Affected individuals are prone to recurrent sinobronchopulmonary infections, lymphoreticular neoplasms, and other malignancies. Serum ALPHA-FETOPROTEINS are usually elevated. (Menkes, Textbook of Child Neurology, 5th ed, p688) The gene for this disorder (ATM) encodes a cell cycle checkpoint protein kinase and has been mapped to chromosome 11 (11q22-q23).
DNA-Activated Protein Kinase
Models, Biological
DNA-Binding Proteins
Four-Dimensional Computed Tomography
Radiographic Image Interpretation, Computer-Assisted
Fibroblasts
DNA
A deoxyribonucleotide polymer that is the primary genetic material of all cells. Eukaryotic and prokaryotic organisms normally contain DNA in a double-stranded state, yet several important biological processes transiently involve single-stranded regions. DNA, which consists of a polysugar-phosphate backbone possessing projections of purines (adenine and guanine) and pyrimidines (thymine and cytosine), forms a double helix that is held together by hydrogen bonds between these purines and pyrimidines (adenine to thymine and guanine to cytosine).
Cone-Beam Computed Tomography
Dacarbazine
Mutation
Misonidazole
Fluorouracil
Xenograft Model Antitumor Assays
Feasibility Studies
Molecular Sequence Data
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Risk Factors
Samarium
Strontium Radioisotopes
Protein-Serine-Threonine Kinases
Radon
Carcinoma, Non-Small-Cell Lung
Magnetic Resonance Imaging
Hyperthermia, Induced
Cell Cycle Proteins
Proteins that control the CELL DIVISION CYCLE. This family of proteins includes a wide variety of classes, including CYCLIN-DEPENDENT KINASES, mitogen-activated kinases, CYCLINS, and PHOSPHOPROTEIN PHOSPHATASES as well as their putative substrates such as chromatin-associated proteins, CYTOSKELETAL PROTEINS, and TRANSCRIPTION FACTORS.
Plutonium
Plutonium. A naturally radioactive element of the actinide metals series. It has the atomic symbol Pu, atomic number 94, and atomic weight 242. Plutonium is used as a nuclear fuel, to produce radioisotopes for research, in radionuclide batteries for pacemakers, and as the agent of fission in nuclear weapons.
Fast Neutrons
Radioisotope Teletherapy
Tissue Distribution
Accumulation of a drug or chemical substance in various organs (including those not relevant to its pharmacologic or therapeutic action). This distribution depends on the blood flow or perfusion rate of the organ, the ability of the drug to penetrate organ membranes, tissue specificity, protein binding. The distribution is usually expressed as tissue to plasma ratios.
Sarcoma
Radiation target analysis indicates that phenylalanine hydroxylase in rat liver extracts is a functional monomer. (1/181)
The minimal enzymatically functional form of purified rat hepatic phenylalanine hydroxylase (PAH) is a dimer of identical subunits. Radiation target analysis of PAH revealed that the minimal enzymatically active form in crude extracts corresponds to the monomer. The 'negative regulation' properties of the tetrahydrobiopterin cofactor in both crude and pure samples implicates a large multimeric structure, minimally a tetramer of PAH subunits. Preincubation of the samples with phenylalanine prior to irradiation abolished this inhibition component without affecting the minimal functional unit target sizes of the enzyme in both preparations. The characteristics of rat hepatic PAH determined by studies of the purified enzyme in vitro may not completely represent the properties of PAH in vivo. (+info)Case study of the effects of atmospheric aerosols and regional haze on agriculture: an opportunity to enhance crop yields in China through emission controls? (2/181)
The effect of atmospheric aerosols and regional haze from air pollution on the yields of rice and winter wheat grown in China is assessed. The assessment is based on estimates of aerosol optical depths over China, the effect of these optical depths on the solar irradiance reaching the earth's surface, and the response of rice and winter wheat grown in Nanjing to the change in solar irradiance. Two sets of aerosol optical depths are presented: one based on a coupled, regional climate/air quality model simulation and the other inferred from solar radiation measurements made over a 12-year period at meteorological stations in China. The model-estimated optical depths are significantly smaller than those derived from observations, perhaps because of errors in one or both sets of optical depths or because the data from the meteorological stations has been affected by local pollution. Radiative transfer calculations using the smaller, model-estimated aerosol optical depths indicate that the so-called "direct effect" of regional haze results in an approximately 5-30% reduction in the solar irradiance reaching some of China's most productive agricultural regions. Crop-response model simulations suggest an approximately 1:1 relationship between a percentage increase (decrease) in total surface solar irradiance and a percentage increase (decrease) in the yields of rice and wheat. Collectively, these calculations suggest that regional haze in China is currently depressing optimal yields of approximately 70% of the crops grown in China by at least 5-30%. Reducing the severity of regional haze in China through air pollution control could potentially result in a significant increase in crop yields and help the nation meet its growing food demands in the coming decades. (+info)Rejoining of radiation-induced single-strand breaks in deoxyribonucleic acid of Escherichia coli: effect of phenethyl alcohol. (3/181)
Single-strand breaks in deoxyribonucleic acid of Escherichia coli B/r cells exposed to 20 krads of gamma radiation could be rejoined by incubation of irradiated cells in growth medium. In the presence of 0.25% phenethyl alcohol, this repair was completely inhibited although deoxyribonucleic acid and protein syntheses were suppressed only partially. (+info)Promotion of secondary anti-DNP antibody production in mice by type III pneumococcal polysaccharide (SIII) and dinitrophenylated rabbit antibody to SIII. (4/181)
Type III pneumococcal polysaccharide (SIII) is able markedly to increase the adoptive IgG ANTI-DNP antibody response of B cells primed to DNP-flagellin and stimulated with DNP conjugated to the heterologous carrier, rabbit globulin, provided the latter has anti-SIII activity. The stimulatory effect is apparently accessory cell-dependent as well as being unequivocally T cell-dependent. Although no positive evidence is available, the possibility exists that non-specific T-cell activation is involved in the stimulating effect of anti-SIII plus SIII. (+info)Male infertility risk factors in a French military population. (5/181)
We investigated infertility risk factors by conducting a population-based case-control study in the military population of the French town of Brest. Sixty couples who had sought medical advice for infertility of more than 12 months duration (cases) were compared with 165 couples who had had a child (controls). All the men in these couples had been employed by the military. The infertility risk factors studied were male and female medical factors, occupational and environmental exposures. We obtained age-adjusted odds ratios of 7.4 [95% confidence interval (CI): 1.4--39.5] for testis surgery, and 13.0 for varicocele (95% CI: 1.4--120.3) in men. In logistic regression, the age-adjusted odds ratio for men who had worked in a nuclear submarine was found to be 2.0 (95% CI: 1.0--3.7), and that for heat exposure was 4.5 (95% CI: 1.9--10.6). One limitation of this study is the lack of exposure measurements, especially for potential exposure to nuclear radiation (type of reactor used in nuclear-powered submarines, inability to obtain personal dosimeters worn by military personnel working in nuclear submarines). In conclusion, this study suggests that in this military population, having worked as a submariner in a nuclear-powered submarine, and having worked in very hot conditions, should be considered as risk factors for infertility. (+info)Calcium protects differentiating neuroblastoma cells during 50 Hz electromagnetic radiation. (6/181)
Despite growing concern about electromagnetic radiation, the interaction between 50- to 60-Hz fields and biological structures remains obscure. Epidemiological studies have failed to prove a significantly correlation between exposure to radiation fields and particular pathologies. We demonstrate that a 50- to 60-Hz magnetic field interacts with cell differentiation through two opposing mechanisms: it antagonizes the shift in cell membrane surface charges that occur during the early phases of differentiation and it modulates hyperpolarizing K channels by increasing intracellular Ca. The simultaneous onset of both mechanisms prevents alterations in cell differentiation. We propose that cells are normally protected against electromagnetic insult. Pathologies may arise, however, if intracellular Ca regulation or K channel activation malfunctions. (+info)P(7/181)
ersonal view: (+info)The farnesyl transferase inhibitor RPR-130401 does not alter radiation susceptibility in human tumor cells with a K-Ras mutation in spite of large changes in ploidy and lamin B distribution. (8/181)
BACKGROUND: Growth inhibition by RPR-130401, a non-peptidomimetic farnesyltransferase inhibitor, was investigated without or with combined exposure to ionizing radiation in three human tumor cell lines (HCT-116, MiAPaCa-2 and A-549) bearing a point mutation in the K-Ras gene. RESULTS: RPR-130401 inhibited cell growth with an IC50 of 50 nM (HCT-116), 120 nM (MiAPaCa-2) and 710 nM (A-549), with a poor incidence of apoptosis. The drug brought about G1 and S phase depletion together with arrest of cells in G2 phase and induced a significant accumulation of hyperploid cells showing active S phase DNA synthesis, with HCT-116 and A-549 cells being the most and least responsive, respectively. The drug also produced dramatic changes of the nuclear lamin B pattern, without lamin B cleavage and perturbation of the actin cytoskeleton. On the other hand, RPR-130401 elicited strictly additive interaction in combined treatment with ionizing radiation with regard to cell kill, altered cell cycle progression and induced hyperploidy. CONCLUSIONS: The data suggest that disruption of orderly progression through mitosis and cytokinesis, is a major outcome of drug action and that this effect proceeds from inhibition of lamin B farnesylation. It is anticipated from the strict additivity of RPR-130401 and radiation that neither induced radiation resistance nor acute or late complications of radiotherapy, should occur in combined treatment with RPR-130401. (+info)
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Detection1
- Welcome, these forums are for professional and amateur scientists to discuss matters relating to radiation detection, and to facilitate friendly and honest collaboration. (gammaspectacular.com)
Electromagnetic radiation1
- Sign up and stay up-to-date with the latest news articles and research on earthing & electromagnetic radiation as well as advice for reducing EMF exposure for you and your family! (earthingoz.com.au)
Longwave2
- Dear Sir/Madam, I am wondering how to derive the incident longwave radiation from MERRA-2, such as the one commonly used to drive land surface models offline as one of the main near-surface meteorological forcing variables. (nasa.gov)
- Validated short wave and longwave in and outgoing radiation at the surface from Cabauw at 10 minute timebasis. (knmi.nl)
Solar radiation1
- and no mention or members who have found and purchased solar radiation meters for the potential kill shot that will occur as the dwarf star proceeds between Earth and the sun, currently seen as around mid october through december 2011. (yowusa.com)
Leak1
- No employees received dangerous doses of radiation, according to officials, who are now devising a plan to determine the cause of the leak. (netc.com)
Exposure2
- It also has issued a formal evacuation notice to residents of five towns and villages outside the zone due to the threat of long-term radiation exposure. (cn-em.com)
- 13 people tested POSITIVE for exposure to Radiation exposure at the MIPP site just east of Carlsbad, New Mexico. (learnnavi.org)
Geiger3
- Please take your Geiger counter with you a record the location, time, radiation readings, and pictures too. (netc.com)
- I hook it up to the free Internet at the hotel and wanted to check my radiation data but the two mobile Geiger counters units were connected to Netc network, without a password and my Kindle computer was connected to the hotels network. (netc.com)
- Last Friday environmental economist Bremley WB Lyngdoh claimed to have discovered high levels of radiation at the site using a Geiger counter. (highlandpost.com)
Nuclear3
- I have only seen mention of 1 nuclear radiation meter, not very portable. (yowusa.com)
- A small-scale nuclear reactor at a government neutron research facility was shut down last week after it began to spew elevated amounts of ionizing radiation. (netc.com)
- TOKYO The immediate danger of explosions or major radiation leaks at the Fukushima Daiichi nuclear-power plant has receded, an administration official said. (cn-em.com)
Topic1
- Author Topic: Radiation: More Terrifying Than Night Air? (nukeworker.com)
Read2
- The fire was a vehicle fire (which seem a lot more common today than 20 years ago) totally unrelated event and never posed a radiation hazard, from what I have read. (learnnavi.org)
- Read the latest manga Radiation House Chapter 46 Bahasa Indonesia at SEKTEKOMIK . (sektekomik.com)
Levels4
- The reactor was shut down and placed in a safety mode, and it won't return to service until the "cause of the elevated radiation levels is determined and corrected," per the statement. (netc.com)
- The effort, however, is being made difficult by two problems: Radiation levels within the damaged reactors must be lowered to allow workers to carry out tasks and it must find ways to process contaminated water generated as a result of cooling. (cn-em.com)
- Elevated levels of radiation were detected HALF A MILE OUTSIDE the plant complex. (learnnavi.org)
- Limits on levels of radiation. (wa.gov)
Incident1
- Or is it a minor incident blown out of proportion because the word RADIATION appears in the story? (learnnavi.org)
Observations2
- Three files consisting of a txt file dataset of gamma radiation count observations, with SLAM estimated position, and a 2D SLAM map of the Jožef Stefan Institute (JSI) TRIGA Mark II reactor hall. (manchester.ac.uk)
- This dataset is then post-processed to provide interpolated maps of gamma radiation, based on the point observations and maps in these files. (manchester.ac.uk)
Theory1
- I just watched a video where it is said that Hawking's radiation theory is a link between quantum mechanics and general relativity and that it can explain the theory of everything if it is developed further.Can someone be kind enough to tell me how that can happen? (thenakedscientists.com)
Data3
- My phone will pass the radiation data to Netc.con, if only it had power. (netc.com)
- I've been analyzing the data available in Giovanni platform about the Photosynthetically Available Radiation (PAR), and the problem is that the values I can obtain are the "integrated" ones in W/m2, but I cannot get their spectral power distribution (SPD) through the visible range for analyzing the spectral variation during the day and estimate sun chromatic coordinates. (nasa.gov)
- The JSI_radiation_data.txt consists of comma separated values, with a header row indicating the data types. (manchester.ac.uk)
Surface2
High1
- There is no truth to the allegations of a high level of radiation leakage at the uranium exploratory drilling site in Nongbah-Jynrin, Chief Minister Conrad K Sangma said today. (highlandpost.com)
Source1
- A radiation source almost everywhere aviable is Radon-222 and its decay products. (gammaspectacular.com)
Form1
- Not only does the covers block over 99% of RF, it also blocks 92% of ELF (another major form of radiation that most cases do not block). (earthingoz.com.au)
Areas2
- This thread is for Road Trips to different areas to take radiation readings. (netc.com)
- Japanese officials and lawmakers are starting to look into potential causes and the handling of the accident that spread radiation to wide areas and forced tens of thousands of residents to evacuate from their homes, said Mr. Hosono. (cn-em.com)
Enter1
- Anti-Radiation -- FCC certified lab tested radiation shielding material is integrated into the front flap to deflect and absorb radiation away from your body while still allowing signal to enter and exit the back of the phone. (earthingoz.com.au)
Types2
- The shielding material is made of a lightweight, lead-free metallic alloy foil, specially engineered to block all three types of radiation emitted by your devices (ELF, RF and Thermal). (earthingoz.com.au)
- Did you know that there are two types of UV radiation? (lifebeautyandliving.com)
Time1
- Transformed daily time series for global radiation for the KNMI'14 scenarios for around 2030, 2050 and 2085 for 14 stations in the Netherlands (revised 2015). (knmi.nl)
Science1
- Let's take a short science lesson in UV radiation. (lifebeautyandliving.com)
Hide1
- In fact, it's nearly impossible to simply hide from UV radiation since most of the rays that reach the earth are scattered light. (lifebeautyandliving.com)
Force1
- Remember, radiation is an invisible force like ghosts or spirits, some will not hurt you in small quantities and others will kill you. (netc.com)
Mobile1
- Smart, stylish and protective, SafeSleeve cases use FCC-certified lab proven radiation shielding material to block up to 99% of RF radiation and over 92% of ELF radiation from your mobile. (earthingoz.com.au)
Amateur1
- Neutrons are the key signature of fusion, but other radiations are of interest to the amateur fusioneer as well. (fusor.net)
Life1
- The first step is to build an Early Warning Radiation Detector with siren to warn us went we are outside and enjoying life. (netc.com)
Material1
- The southwest side in covered with this gray-green material that seem to hold down the smell and radiation. (netc.com)
Short1
- We are pleased to commence announcing the shortlisted authors and winners of the ANNIHILATION RADIATION Short Story Competition. (storgy.com)