A class of plasmids that transfer antibiotic resistance from one bacterium to another by conjugation.
Vertical transmission of hereditary characters by DNA from cytoplasmic organelles such as MITOCHONDRIA; CHLOROPLASTS; and PLASTIDS, or from PLASMIDS or viral episomal DNA.
The ability of microorganisms, especially bacteria, to resist or to become tolerant to chemotherapeutic agents, antimicrobial agents, or antibiotics. This resistance may be acquired through gene mutation or foreign DNA in transmissible plasmids (R FACTORS).
A subdiscipline of genetics which deals with the genetic mechanisms and processes of microorganisms.
A naphthacene antibiotic that inhibits AMINO ACYL TRNA binding during protein synthesis.
An antibiotic first isolated from cultures of Streptomyces venequelae in 1947 but now produced synthetically. It has a relatively simple structure and was the first broad-spectrum antibiotic to be discovered. It acts by interfering with bacterial protein synthesis and is mainly bacteriostatic. (From Martindale, The Extra Pharmacopoeia, 29th ed, p106)
A parasexual process in BACTERIA; ALGAE; FUNGI; and ciliate EUKARYOTA for achieving exchange of chromosome material during fusion of two cells. In bacteria, this is a uni-directional transfer of genetic material; in protozoa it is a bi-directional exchange. In algae and fungi, it is a form of sexual reproduction, with the union of male and female gametes.
An antibiotic produced by the soil actinomycete Streptomyces griseus. It acts by inhibiting the initiation and elongation processes during protein synthesis.
A genus of gram-negative, facultatively anaerobic, rod-shaped bacteria that occurs in the intestines of humans and a wide variety of animals, as well as in manure, soil, and polluted waters. Its species are pathogenic, causing urinary tract infections and are also considered secondary invaders, causing septic lesions at other sites of the body.
A species of gram-negative, facultatively anaerobic, rod-shaped bacteria (GRAM-NEGATIVE FACULTATIVELY ANAEROBIC RODS) commonly found in the lower part of the intestine of warm-blooded animals. It is usually nonpathogenic, but some strains are known to produce DIARRHEA and pyogenic infections. Pathogenic strains (virotypes) are classified by their specific pathogenic mechanisms such as toxins (ENTEROTOXIGENIC ESCHERICHIA COLI), etc.
A species of gram-negative, facultatively anaerobic, rod-shaped bacteria that is frequently isolated from clinical specimens. Its most common site of infection is the urinary tract.
Compounds based on 4-aminobenzenesulfonamide. The '-anil-' part of the name refers to aniline.
The branch of science concerned with the means and consequences of transmission and generation of the components of biological inheritance. (Stedman, 26th ed)
A beta-lactamase preferentially cleaving penicillins. (Dorland, 28th ed) EC 3.5.2.-.
Viruses whose host is Escherichia coli.
A cephalosporin antibiotic.
A genus of gram-negative, facultatively anaerobic, rod-shaped bacteria whose organisms arrange singly, in pairs, or short chains. This genus is commonly found in the intestinal tract and is an opportunistic pathogen that can give rise to bacteremia, pneumonia, urinary tract and several other types of human infection.
Broad-spectrum semisynthetic penicillin derivative used parenterally. It is susceptible to gastric juice and penicillinase and may damage platelet function.
Tungsten hydroxide oxide phosphate. A white or slightly yellowish-green, slightly efflorescent crystal or crystalline powder. It is used as a reagent for alkaloids and many other nitrogen bases, for phenols, albumin, peptone, amino acids, uric acid, urea, blood, and carbohydrates. (From Merck Index, 11th ed)
A semi-synthetic aminoglycoside antibiotic that is used in the treatment of TUBERCULOSIS.
The scattering of x-rays by matter, especially crystals, with accompanying variation in intensity due to interference effects. Analysis of the crystal structure of materials is performed by passing x-rays through them and registering the diffraction image of the rays (CRYSTALLOGRAPHY, X-RAY). (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
Antibiotic complex produced by Streptomyces fradiae. It is composed of neomycins A, B, and C. It acts by inhibiting translation during protein synthesis.
Viruses whose host is Salmonella. A frequently encountered Salmonella phage is BACTERIOPHAGE P22.
Nonsusceptibility of an organism to the action of penicillins.
A serotype of Salmonella enterica that is a frequent agent of Salmonella gastroenteritis in humans. It also causes PARATYPHOID FEVER.
The study of crystal structure using X-RAY DIFFRACTION techniques. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
Deoxyribonucleic acid that makes up the genetic material of bacteria.
Semi-synthetic derivative of penicillin that functions as an orally active broad-spectrum antibiotic.
A member of the alkali metals. It has an atomic symbol Cs, atomic number 50, and atomic weight 132.91. Cesium has many industrial applications, including the construction of atomic clocks based on its atomic vibrational frequency.
The phenomenon by which a temperate phage incorporates itself into the DNA of a bacterial host, establishing a kind of symbiotic relation between PROPHAGE and bacterium which results in the perpetuation of the prophage in all the descendants of the bacterium. Upon induction (VIRUS ACTIVATION) by various agents, such as ultraviolet radiation, the phage is released, which then becomes virulent and lyses the bacterium.
A genus of gram-negative, facultatively anaerobic, rod-shaped bacteria that utilizes citrate as a sole carbon source. It is pathogenic for humans, causing enteric fevers, gastroenteritis, and bacteremia. Food poisoning is the most common clinical manifestation. Organisms within this genus are separated on the basis of antigenic characteristics, sugar fermentation patterns, and bacteriophage susceptibility.
Any of the covalently closed DNA molecules found in bacteria, many viruses, mitochondria, plastids, and plasmids. Small, polydisperse circular DNA's have also been observed in a number of eukaryotic organisms and are suggested to have homology with chromosomal DNA and the capacity to be inserted into, and excised from, chromosomal DNA. It is a fragment of DNA formed by a process of looping out and deletion, containing a constant region of the mu heavy chain and the 3'-part of the mu switch region. Circular DNA is a normal product of rearrangement among gene segments encoding the variable regions of immunoglobulin light and heavy chains, as well as the T-cell receptor. (Riger et al., Glossary of Genetics, 5th ed & Segen, Dictionary of Modern Medicine, 1992)
A species of gram-negative, facultatively anaerobic, rod-shaped bacteria that is extremely pathogenic and causes severe dysentery. Infection with this organism often leads to ulceration of the intestinal epithelium.
Models used experimentally or theoretically to study molecular shape, electronic properties, or interactions; includes analogous molecules, computer-generated graphics, and mechanical structures.
Separation of particles according to density by employing a gradient of varying densities. At equilibrium each particle settles in the gradient at a point equal to its density. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
Substances that reduce the growth or reproduction of BACTERIA.
A genus of gram-negative, facultatively anaerobic, rod-shaped bacteria that ferments sugar without gas production. Its organisms are intestinal pathogens of man and other primates and cause bacillary dysentery (DYSENTERY, BACILLARY).
A family of gram-negative, facultatively anaerobic, rod-shaped bacteria that do not form endospores. Its organisms are distributed worldwide with some being saprophytes and others being plant and animal parasites. Many species are of considerable economic importance due to their pathogenic effects on agriculture and livestock.
Structures within the nucleus of bacterial cells consisting of or containing DNA, which carry genetic information essential to the cell.
A short-acting sulfonamide antibacterial with activity against a wide range of gram- negative and gram-positive organisms.
The totality of characteristics of reproductive structure, functions, PHENOTYPE, and GENOTYPE, differentiating the MALE from the FEMALE organism.
A group of compounds that contain the structure SO2NH2.
Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.
The formation of crystalline substances from solutions or melts. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
A species of gram-negative, facultatively anaerobic, rod-shaped bacteria found in soil, water, food, and clinical specimens. It is a prominent opportunistic pathogen for hospitalized patients.
A synthetic 1,8-naphthyridine antimicrobial agent with a limited bacteriocidal spectrum. It is an inhibitor of the A subunit of bacterial DNA GYRASE.
Viruses whose hosts are bacterial cells.
The characteristic 3-dimensional shape of a protein, including the secondary, supersecondary (motifs), tertiary (domains) and quaternary structure of the peptide chain. PROTEIN STRUCTURE, QUATERNARY describes the conformation assumed by multimeric proteins (aggregates of more than one polypeptide chain).
A category of nucleic acid sequences that function as units of heredity and which code for the basic instructions for the development, reproduction, and maintenance of organisms.
A genus of gram-negative, facultatively anaerobic, rod-shaped bacteria whose organisms occur in the lower part of the intestine of warm-blooded animals. The species are either nonpathogenic or opportunistic pathogens.
A salt used to replenish calcium levels, as an acid-producing diuretic, and as an antidote for magnesium poisoning.
A plasmid whose presence in the cell, either extrachromosomal or integrated into the BACTERIAL CHROMOSOME, determines the "sex" of the bacterium, host chromosome mobilization, transfer via conjugation (CONJUGATION, GENETIC) of genetic material, and the formation of SEX PILI.
Production of new arrangements of DNA by various mechanisms such as assortment and segregation, CROSSING OVER; GENE CONVERSION; GENETIC TRANSFORMATION; GENETIC CONJUGATION; GENETIC TRANSDUCTION; or mixed infection of viruses.
The effects of ionizing and nonionizing radiation upon living organisms, organs and tissues, and their constituents, and upon physiologic processes. It includes the effect of irradiation on food, drugs, and chemicals.
A species of gram-negative, aerobic, rod-shaped bacteria commonly isolated from clinical specimens (wound, burn, and urinary tract infections). It is also found widely distributed in soil and water. P. aeruginosa is a major agent of nosocomial infection.
A trypanocidal agent and possible antiviral agent that is widely used in experimental cell biology and biochemistry. Ethidium has several experimentally useful properties including binding to nucleic acids, noncompetitive inhibition of nicotinic acetylcholine receptors, and fluorescence among others. It is most commonly used as the bromide.
A commonly used laboratory solvent. It was previously used as an anesthetic, but was banned from use in the U.S. due to its suspected carcinogenicity.
Any liquid or solid preparation made specifically for the growth, storage, or transport of microorganisms or other types of cells. The variety of media that exist allow for the culturing of specific microorganisms and cell types, such as differential media, selective media, test media, and defined media. Solid media consist of liquid media that have been solidified with an agent such as AGAR or GELATIN.
A pyrimidine inhibitor of dihydrofolate reductase, it is an antibacterial related to PYRIMETHAMINE. It is potentiated by SULFONAMIDES and the TRIMETHOPRIM, SULFAMETHOXAZOLE DRUG COMBINATION is the form most often used. It is sometimes used alone as an antimalarial. TRIMETHOPRIM RESISTANCE has been reported.
Bacteriocins elaborated by strains of Escherichia coli and related species. They are proteins or protein-lipopolysaccharide complexes lethal to other strains of the same species.
The property of objects that determines the direction of heat flow when they are placed in direct thermal contact. The temperature is the energy of microscopic motions (vibrational and translational) of the particles of atoms.
The sum of the weight of all the atoms in a molecule.
A low-energy attractive force between hydrogen and another element. It plays a major role in determining the properties of water, proteins, and other compounds.
Critical and exhaustive investigation or experimentation, having for its aim the discovery of new facts and their correct interpretation, the revision of accepted conclusions, theories, or laws in the light of newly discovered facts, or the practical application of such new or revised conclusions, theories, or laws. (Webster, 3d ed)
A complex of closely related aminoglycosides obtained from MICROMONOSPORA purpurea and related species. They are broad-spectrum antibiotics, but may cause ear and kidney damage. They act to inhibit PROTEIN BIOSYNTHESIS.
A genus of gram-negative, facultatively anaerobic, rod-shaped bacteria whose organisms are associated with plants as pathogens, saprophytes, or as constituents of the epiphytic flora.
Cells, usually bacteria or yeast, which have partially lost their cell wall, lost their characteristic shape and become round.
A discipline concerned with studying biological phenomena in terms of the chemical and physical interactions of molecules.
The adhesion of gases, liquids, or dissolved solids onto a surface. It includes adsorptive phenomena of bacteria and viruses onto surfaces as well. ABSORPTION into the substance may follow but not necessarily.
The parts of a macromolecule that directly participate in its specific combination with another molecule.
Inorganic compounds derived from hydrochloric acid that contain the Cl- ion.
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
The branch of science that deals with the geometric description of crystals and their internal arrangement. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
Centrifugation using a rotating chamber of large capacity in which to separate cell organelles by density-gradient centrifugation. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
That portion of the electromagnetic spectrum immediately below the visible range and extending into the x-ray frequencies. The longer wavelengths (near-UV or biotic or vital rays) are necessary for the endogenous synthesis of vitamin D and are also called antirachitic rays; the shorter, ionizing wavelengths (far-UV or abiotic or extravital rays) are viricidal, bactericidal, mutagenic, and carcinogenic and are used as disinfectants.
Enzymes catalyzing the transfer of an acetyl group, usually from acetyl coenzyme A, to another compound. EC 2.3.1.
Unstable isotopes of sulfur that decay or disintegrate spontaneously emitting radiation. S 29-31, 35, 37, and 38 are radioactive sulfur isotopes.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
A nonreducing disaccharide composed of GLUCOSE and FRUCTOSE linked via their anomeric carbons. It is obtained commercially from SUGARCANE, sugar beet (BETA VULGARIS), and other plants and used extensively as a food and a sweetener.
Microscopy using an electron beam, instead of light, to visualize the sample, thereby allowing much greater magnification. The interactions of ELECTRONS with specimens are used to provide information about the fine structure of that specimen. In TRANSMISSION ELECTRON MICROSCOPY the reactions of the electrons that are transmitted through the specimen are imaged. In SCANNING ELECTRON MICROSCOPY an electron beam falls at a non-normal angle on the specimen and the image is derived from the reactions occurring above the plane of the specimen.
Stable phosphorus atoms that have the same atomic number as the element phosphorus, but differ in atomic weight. P-31 is a stable phosphorus isotope.
A process of separating particulate matter from a fluid, such as air or a liquid, by passing the fluid carrier through a medium that will not pass the particulates. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
Change brought about to an organisms genetic composition by unidirectional transfer (TRANSFECTION; TRANSDUCTION, GENETIC; CONJUGATION, GENETIC, etc.) and incorporation of foreign DNA into prokaryotic or eukaryotic cells by recombination of part or all of that DNA into the cell's genome.
Unstable isotopes of carbon that decay or disintegrate emitting radiation. C atoms with atomic weights 10, 11, and 14-16 are radioactive carbon isotopes.
The process by which a DNA molecule is duplicated.
A pyrimidine base that is a fundamental unit of nucleic acids.
Glycosylated compounds in which there is an amino substituent on the glycoside. Some of them are clinically important ANTIBIOTICS.
A genus of gram-negative, aerobic, rod-shaped bacteria widely distributed in nature. Some species are pathogenic for humans, animals, and plants.
Electrophoresis in which a pH gradient is established in a gel medium and proteins migrate until they reach the site (or focus) at which the pH is equal to their isoelectric point.
Any tests that demonstrate the relative efficacy of different chemotherapeutic agents against specific microorganisms (i.e., bacteria, fungi, viruses).
An aldohexose that occurs naturally in the D-form in lactose, cerebrosides, gangliosides, and mucoproteins. Deficiency of galactosyl-1-phosphate uridyltransferase (GALACTOSE-1-PHOSPHATE URIDYL-TRANSFERASE DEFICIENCY DISEASE) causes an error in galactose metabolism called GALACTOSEMIA, resulting in elevations of galactose in the blood.
The level of protein structure in which regular hydrogen-bond interactions within contiguous stretches of polypeptide chain give rise to alpha helices, beta strands (which align to form beta sheets) or other types of coils. This is the first folding level of protein conformation.
Proteins found in any species of bacterium.
Refuse liquid or waste matter carried off by sewers.
Techniques to partition various components of the cell into SUBCELLULAR FRACTIONS.
Lengthy and continuous deprivation of food. (Stedman, 25th ed)
Centrifugation with a centrifuge that develops centrifugal fields of more than 100,000 times gravity. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
The marking of biological material with a dye or other reagent for the purpose of identifying and quantitating components of tissues, cells or their extracts.
A sulfur-containing essential L-amino acid that is important in many body functions.
Highly repetitive DNA sequences found in HETEROCHROMATIN, mainly near centromeres. They are composed of simple sequences (very short) (see MINISATELLITE REPEATS) repeated in tandem many times to form large blocks of sequence. Additionally, following the accumulation of mutations, these blocks of repeats have been repeated in tandem themselves. The degree of repetition is on the order of 1000 to 10 million at each locus. Loci are few, usually one or two per chromosome. They were called satellites since in density gradients, they often sediment as distinct, satellite bands separate from the bulk of genomic DNA owing to a distinct BASE COMPOSITION.
Any method used for determining the location of and relative distances between genes on a chromosome.
Excrement from the INTESTINES, containing unabsorbed solids, waste products, secretions, and BACTERIA of the DIGESTIVE SYSTEM.
Stable carbon atoms that have the same atomic number as the element carbon, but differ in atomic weight. C-13 is a stable carbon isotope.
The location of the atoms, groups or ions relative to one another in a molecule, as well as the number, type and location of covalent bonds.
Techniques used in studying bacteria.
Techniques used to separate mixtures of substances based on differences in the relative affinities of the substances for mobile and stationary phases. A mobile phase (fluid or gas) passes through a column containing a stationary phase of porous solid or liquid coated on a solid support. Usage is both analytical for small amounts and preparative for bulk amounts.
Enzymes from the transferase class that catalyze the transfer of acyl groups from donor to acceptor, forming either esters or amides. (From Enzyme Nomenclature 1992) EC 2.3.
Anaerobic degradation of GLUCOSE or other organic nutrients to gain energy in the form of ATP. End products vary depending on organisms, substrates, and enzymatic pathways. Common fermentation products include ETHANOL and LACTIC ACID.
Extrachromosomal, usually CIRCULAR DNA molecules that are self-replicating and transferable from one organism to another. They are found in a variety of bacterial, archaeal, fungal, algal, and plant species. They are used in GENETIC ENGINEERING as CLONING VECTORS.
The accumulation of an electric charge on a object
Organic compounds that generally contain an amino (-NH2) and a carboxyl (-COOH) group. Twenty alpha-amino acids are the subunits which are polymerized to form proteins.
The degree of similarity between sequences of amino acids. This information is useful for the analyzing genetic relatedness of proteins and species.
The spatial arrangement of the atoms of a nucleic acid or polynucleotide that results in its characteristic 3-dimensional shape.
The level of protein structure in which combinations of secondary protein structures (alpha helices, beta sheets, loop regions, and motifs) pack together to form folded shapes called domains. Disulfide bridges between cysteines in two different parts of the polypeptide chain along with other interactions between the chains play a role in the formation and stabilization of tertiary structure. Small proteins usually consist of only one domain but larger proteins may contain a number of domains connected by segments of polypeptide chain which lack regular secondary structure.
The restriction of a characteristic behavior, anatomical structure or physical system, such as immune response; metabolic response, or gene or gene variant to the members of one species. It refers to that property which differentiates one species from another but it is also used for phylogenetic levels higher or lower than the species.
The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments.
The arrangement of two or more amino acid or base sequences from an organism or organisms in such a way as to align areas of the sequences sharing common properties. The degree of relatedness or homology between the sequences is predicted computationally or statistically based on weights assigned to the elements aligned between the sequences. This in turn can serve as a potential indicator of the genetic relatedness between the organisms.
Any of various animals that constitute the family Suidae and comprise stout-bodied, short-legged omnivorous mammals with thick skin, usually covered with coarse bristles, a rather long mobile snout, and small tail. Included are the genera Babyrousa, Phacochoerus (wart hogs), and Sus, the latter containing the domestic pig (see SUS SCROFA).
Widely used technique which exploits the ability of complementary sequences in single-stranded DNAs or RNAs to pair with each other to form a double helix. Hybridization can take place between two complimentary DNA sequences, between a single-stranded DNA and a complementary RNA, or between two RNA sequences. The technique is used to detect and isolate specific sequences, measure homology, or define other characteristics of one or both strands. (Kendrew, Encyclopedia of Molecular Biology, 1994, p503)

Functional importance and local environments of the cysteines in the tetracycline resistance protein encoded by plasmid pBR322. (1/1266)

The properties of the cysteines in the pBR322-encoded tetracycline resistance protein have been examined. Cysteines are important but not essential for tetracycline transport activity. None of the cysteines reacted with biotin maleimide, suggesting that they are shielded from the aqueous phase or reside in a negatively charged local environment.  (+info)

Phage type conversion in Salmonella enterica serotype Enteritidis caused by the introduction of a resistance plasmid of incompatibility group X (IncX). (2/1266)

The plasmid pOG670, a 54 kb, conjugative plasmid that specifies resistance to ampicillin and kanamycin and belonging to the incompatibility group X (IncX), was transferred into 10 isolates of Salmonella enterica serotype Enteritidis belonging to 10 different phage types (PT1, 2, 3, 4, 8, 9, 9b, 10, 11 and 13). Acquisition of the plasmid by these strains did not result in the loss of any resident plasmids but resulted in phage type conversion in 8 of the 10 strains (PT1, 2, 4, 8, 9, 9b, 10 and 11). The observed changes in phage type were found to result from the loss of sensitivity to 3 of the 10 typing phages used (phages 3, 5 and 7). Where the conversion resulted in a change to a defined phage type, both the new and original PTs belonged to the same, previously described, evolutionary lines. Enteritidis PTs 1, 4 and 8, commonly associated with poultry world-wide, were converted to PTs 21, 6 and 13a respectively. The results indicate a different route for phage type conversion Enteritidis from others reported in the literature and, although IncX plasmids are not normally present in PT8 or PT13a, may suggest a possible mechanism/link connecting these phage types.  (+info)

An explanation for the apparent host specificity of Pseudomonas plasmid R91 expression. (3/1266)

Pseudomonas aeruginosa strain 9169 has been reported to contain a plasmid that expresses resistance to carbenicillin (Cb), kanamycin (Km), and tetracycline (Tc) in Escherichia coli but resistance only to Cb in certain Pseudomonas recipients. The triply resistant plasmid in E. coli belonged to incompatibility (Inc) group P or P-1, whereas the singly resistant plasmid in P. aeruginosa was compatible with IncP-1 plasmids and other plasmids of established Inc specificity but incompatible with plasmid pSR1 that is here used to define a new Pseudomonas Inc group P-10. Additional physical and genetic studies showed that strain 9169 contained not one but two plasmids: IncP-1 plasmid R91a, determining the Cb Km Tc phenotype, and IncP-10 plasmid R91, determining Cb that differed in molecular weight and in EcoRI and BamHI restriction endonuclease recognition sites. Plasmid multiplicity rather than host effects on plasmid gene expression can account for differences in the phenotype of strain 9169 transconjugants to E. coli and P. aeruginosa.  (+info)

R-factor inheritance and plasmid content in mucoid Pseudomonas aeruginosa. (4/1266)

Eighteen strains of alginate-producing mucoid Pseudomonas aeruginosa were evaluated with respect to plasmid content and the ability to maintain well-characterized R plasmids. The spontaneous loss of alginate production in these strains varied from 0.01 to 0.7% and was not significantly increased by plasmid curing regimens. Examination of cleared lysates of these strains and their isogenic nonmucoid derivatives by agarose gel electrophoresis failed to reveal plasmid DNA. R-plasmid (P-incompatibility-group) transfer to mucoid P. aeruginosa was unaffected by the presence of the alginate capsule. Maintenance and expression of such plasmids in the mucoid strains were confirmed by agarose gel electrophoresis and by verification of plasmid-linked drug resistance and pilus-specific bacteriophage sensitivity. These studies demonstrate that alginate production does not appear to be plasmid linked and that mucoid P. aeruginosa are capable of receiving and donating certain drug resistance plasmids. Since some of the plasmids used here have been shown to mobilize chromosomal DNA, strains constructed in this study should afford the means for exploring the genetic basis of the mucoid phenotype.  (+info)

Immunochemical studies on R mutants of Yersinia enterocolitica O:3. (5/1266)

Three mutants of Yersinia enterocolitica O:3, namely: YeO3-R1, YeO3-RfbR7 and YeO3-c-trs8-R were classified on the basis of sodium dodecyl sulphate/polyacrylamide gel electrophoresis (SDS/PAGE) profile of isolated lipopolysaccharides (LPS) as belonging to the Ra- (the first) and the Rc-type (the other two mutants). Methylation analysis, in addition to 13C and 1H NMR studies of purified core oligosaccharides revealed structures similar to those established previously for the full core of Y. enterocolitica O:3 in the case of the Ra mutant, and identical to that reported for the Rc mutant Ye75R, in the case of the two other mutants. The O-specific sugar, 6d-L-altrose, which forms a homopolymeric O-chain, was present in small amounts in all three LPS preparations, as well as in the core oligosaccha ride preparations along with the Ra and the Rc sugars, characteristic of the Y. enterocolitica O:3 core. This result is in line with genetic data, indicating that it is the inner core region which is the receptor for the O-specific chain in Y. enterocolitica O:3. This region seems likewise to be the anchoring region for the enterobacterial common antigen (ECA), as shown by SDS/PAGE/Western blot analysis with monoclonal antibodies against ECA. In addition, we also demonstrated that the Ye75R mutant Rc and its parental strain Ye75S, both were ECA-immunogenic strains. So far, ECA-immunogenic strains, i.e. those with LPS-linked ECA, were only identified in E. coli mutants of the R1, R4 and K-12 serotype.  (+info)

Comparison of proteins involved in pilus synthesis and mating pair stabilization from the related plasmids F and R100-1: insights into the mechanism of conjugation. (6/1266)

F and R100-1 are closely related, derepressed, conjugative plasmids from the IncFI and IncFII incompatibility groups, respectively. Heteroduplex mapping and genetic analyses have revealed that the transfer regions are extremely similar between the two plasmids. Plasmid specificity can occur at the level of relaxosome formation, regulation, and surface exclusion between the two transfer systems. There are also differences in pilus serology, pilus-specific phage sensitivity, and requirements for OmpA and lipopolysaccharide components in the recipient cell. These phenotypic differences were exploited in this study to yield new information about the mechanism of pilus synthesis, mating pair stabilization, and surface and/or entry exclusion, which are collectively involved in mating pair formation (Mpf). The sequence of the remainder of the transfer region of R100-1 (trbA to traS) has been completed, and the complete sequence is compared to that of F. The differences between the two transfer regions include insertions and deletions, gene duplications, and mosaicism within genes, although the genes essential for Mpf are conserved in both plasmids. F+ cells carrying defined mutations in each of the Mpf genes were complemented with the homologous genes from R100-1. Our results indicate that the specificity in recipient cell recognition and entry exclusion are mediated by TraN and TraG, respectively, and not by the pilus.  (+info)

Molecular epidemiological study on tetracycline resistance R plasmids in enterohaemorrhagic Escherichia coli O157:H7. (7/1266)

Restriction patterns obtained with EcoRI and Southern hybridization were used for the differentiation of tetracycline-resistant (Tet(r)) R plasmids in enterobaemorrhagic Escherichia coli (EHEC) O157:H7 isolates from a mass outbreak at a kindergarten in Obihiro-City, Hokkaido, Japan, 1996. Two kinds of Tet(r) R plasmids of 50 and 95 kb were detected. The 50-kb plasmids were identical to each other, while the 93-kb plasmids were of three types that were very similar to each other. The tet genes of both 50- and 95-kb R plasmids were 100% identical to the tet gene of pSC101 and all plasmids hybridized to a probe for tet. Because food-origin O157 strains were sensitive to tetracycline, we concluded that such Tet(r) R-plasmids might transfer to drug-sensitive O157 strains in the infected individuals.  (+info)

Propagation of TEM- and PSE-type beta-lactamases among amoxicillin-resistant Salmonella spp. isolated in France. (8/1266)

A survey conducted between 1987 and 1994 at the University Hospital of Besancon, France, demonstrated a dramatic increase (from 0 to 42. 5%) in the prevalence of amoxicillin resistance among Salmonella spp. Of the 96 resistant isolates collected during this period (including 77 Typhimurium), 54 were found to produce TEM-1 beta-lactamase, 40 produced PSE-1 (equivalent to CARB-2), one produced PSE-1 plus TEM-2, and one produced OXA-1 in isoelectric focusing and DNA hybridization experiments. Plasmids coding for these beta-lactamases were further characterized by (i) profile analysis, (ii) restriction fragmentation pattern analysis, (iii) hybridization with an spvCD-orfE virulence probe, and (iv) replicon typing. In addition, isolates of S. typhimurium were genotypically compared by pulsed-field gel electrophoresis of XbaI-macrorestricted chromosomal DNA. Altogether, these methods showed that 40 of the 41 PSE-1 producers were actually the progeny of a single epidemic S. typhimurium strain lysotype DT104. Isolates of that strain were found to harbor RepFIC virulence plasmids with somewhat different restriction profiles, but which all carried the bla(PSE-1) gene. Of these virulence/resistance plasmids, 15 were transmissible to Escherichia coli. TEM-1-producing S. typhimurium displayed much greater genotypic and plasmidic diversities, suggesting the acquisition of the bla(TEM-1) gene from multiple bacterial sources by individual strains. In agreement with this, 32 of the 35 S. typhimurium plasmids encoding TEM-1 were found to be conjugative. These data show that development of amoxicillin resistance among Salmonella, especially in serovar Typhimurium, results from both gene transfers and strain dissemination.  (+info)

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Synonyms for R plasmid in Free Thesaurus. Antonyms for R plasmid. 1 synonym for plasmid: plasmid DNA. What are synonyms for R plasmid?
resistance plasmid definition: The definition of a resistance plasmid is a small element outside the chromosome that carries DNA information that fights against antibiotic drugs. (noun) An example of a resistance plasmid is pBR322 which carries the genes for tetr...
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Refinement. Refinement of F2 against ALL reflections. The weighted R-factor wR and goodness of fit S are based on F2, conventional R-factors R are based on F, with F set to zero for negative F2. The threshold expression of F2 > σ(F2) is used only for calculating R-factors(gt) etc. and is not relevant to the choice of reflections for refinement. R-factors based on F2 are statistically about twice as large as those based on F, and R- factors based on ALL data will be even larger. ...
Nucleotide sequence of an OXA-2 beta-lactamase gene from the R-plasmid R1767 derived plasmid pBP11 and comparison to closely related resistance determinants found in R46 and ...
R Factor EA 1.67 BECAME FREE, THANKS FOR SUPPORTING US!!!!. R FACTOR Expert Advisor with Proprietary Dynamic Portfolio Management System. After 4 years of development and almost 3 years of real positive results, we are finally confident in sharing our strategy with the MQL5 community. It has always been important for us that the strategy performed positively for the creator before it could be shared. Skin In The Game is essential to demonstrate the belief in the strategy and also to provide a continuous improvement of it.. Anyone who has been in this market for some time has certainly been there: You develop or acquire a strategy, which has been extensively tested, using methods of robustness, randomness, Walk Forward Analysis, etc., but right when it is applied to your account real it begins to face a difficult period, a long drawdown, a market for which it was not prepared. This may not mean that the strategy has stopped working, only that the market is in a difficult cycle for the strategy at ...
February 25, 2021 , 1:57. If you have three minutes, then you have enough time to install a TFDF® flow path. Mount the device, make a few connections and youre done - without ever breaking a sweat. More from The R Factor. ...
In 2019 we created an engagement and voting screen that leverages R-Factor, our proprietary scoring system. R-Factor measures the performance of a companys business operations and governance as it relates to financially material and industry-specific ESG risk factors, as defined by the Sustainability Accounting Standards Board (SASB).
eurosurveillance.org is the online home of Eurosurveillance, Europes journal on infectious disease surveillance, epidemiology, prevention and control.
Two clinical isolates of Pseudomonas aeruginosa, one a pyocin type 5 strain from Atlanta, could transfer gentamicin resistance by conjugation. Donor and recipient strains inactivated gentamicin by acetylation. The R plasmids, pMG1 and pMG2, also determined resistance to sisomicin, another substrate of gentamicin acetyltransferase I, sulfonamides, and streptomycin, but not resistance to kanamycin, neomycin, tobramycin, butirosin, or BB-K 8. They were transmissible to many strains of P. aeruginosa, including a Rec− strain, but not to Escherichia coli or other enterobacteriaceae. These R plasmids were compatible with R plasmids transmissible to P. aeruginosa from E. coli, including members of C, N, P, and W incompatibility groups. From a strain carrying pMG1 and a compatible plasmid, pMG1 was transferred independently but transfer of the second plasmid often resulted in cotransfer of pMG1. In contrast, pMG1 and pMG2 were incompatible with pseudomonas R plasmids R931 and R3108, and with R931 they ...
Promiscuous plasmids replicate in a wide range of bacteria and therefore play a key role in the dissemination of various host-beneficial traits, including antibiotic resistance. Despite the medical relevance, little is known about the evolutionary dynamics through which drug resistance plasmids adapt to new hosts and thereby persist in the absence of antibiotics. We previously showed that the incompatibility group P-1 (IncP-1) minireplicon pMS0506 drastically improved its stability in novel host Shewanella oneidensis MR-1 after 1,000 generations under antibiotic selection for the plasmid. The only mutations found were those affecting the N terminus of the plasmid replication initiation protein TrfA1. Our aim in this study was to gain insight into the dynamics of plasmid evolution. Changes in stability and genotype frequencies of pMS0506 were monitored in evolving populations of MR-1 (pMS0506). Genotypes were determined by sequencing trfA1 amplicons from individual clones and by 454 ...
SimPlot analysis.Similarity plots with plasmids R751, pBP136 and pB3 as reference plasmids. Each coloured plot corresponds to a specific plasmid depicted in the
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GENETIC BASIS OF RESISTANCE:. Most drug resistance is due to a genetic change in the organism, either as a chromosomal mutation or the acquisition of a plasmid ortransposon. a) CHROMOSOME-MEDIATED-RESISTANCE:. Chromosomal resistance is due to a mutation in the gene that codes for either the target of the drug or the transport system in the membrane that controls the uptake of the drug. The frequency of spontaneous mutations usually ranges from 10~ 7 to 10 ~ 9 which is much lower then the frequency of acquisition of resistance plasmids. Therefore, chromosomal resilience is less of a clinical problem than plasmid. Mediated resistance. b) PLASMID-MED1ATED RESISTANCE:. Plasmid-mediated resistance is very important from clinical point of view for 3 reasons: 1) It occurs in many different species, especially gram negative rods. 2) Plasmida frequently madiate resistance to multiple drugs. 3) Plasmids have a high rate of trans. for from one cell to another, usually by conjugation. Resistance plasmids ...
The R factor is an often quoted measure for the way the Coronavirus is spread. Sandro Debono, a European museum thinker and culture consultant, proposes a museum R factor consisting of 3 elements: Resilience, Relevance and Revenue.
InChI=1S/C30H58O4Si3/c1-28-17-14-23(33-36(6,7)8)20-22(28)12-13-24-25(28)15-18-29(2)26(24)16-19-30(29,34-37(9,10)11)27(31)21-32-35(3,4)5/h22-26H,12-21H2,1- ...
InChI=1S/C26H44O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-20-23-26(27)28-24-25-21-18-17-19-22-25/h17-19,21-22H,2-16,20,23-24H2, ...
InChI=1S/C21H30O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h12,16-19H,4-11H2,1-3H3/t16-,17+,18-,19-,20-,21+/m0/s1 ...
InChI=1S/C29H31N7O/c1-21-5-10-25(18-27(21)34-29-31-13-11-26(33-29)24-4-3-12-30-19-24)32-28(37)23-8-6-22(7-9-23)20-36-16-14-35(2)15-17-36/h3-13,18-19H,14-17,20H2,1-2H3,(H,32,37)(H,31,33,34) ...
InChI=1S/C65H104N18O26S4/c1-25(2)15-34-55(98)80-41-24-113-110-21-38(58(101)77-37(65(108)109)16-26(3)4)71-44(87)20-69-62(105)50(30(10)84)83-61(104)40(78-51(94)29(9)70-63(106)48(27(5)6)81-57(100)35(18-43(68)86)76-64(107)49(28(7)8)82-60(41)103)23-112-111-22-39(59(102)73-32(53(96)75-34)11-13-45(88)89)79-54(97)33(12-14-46(90)91)72-56(99)36(19-47(92)93)74-52(95)31(66)17-42(67)85/h25-41,48-50,84H,11-24,66H2,1-10H3,(H2,67,85)(H2,68,86)(H,69,105)(H,70,106)(H,71,87)(H,72,99)(H,73,102)(H,74,95)(H,75,96)(H,76,107)(H,77,101)(H,78,94)(H,79,97)(H,80,98)(H,81,100)(H,82,103)(H,83,104)(H,88,89)(H,90,91)(H,92,93)(H,108,109)/t29-,30+,31-,32-,33-,34-,35-,36-,37-,38-,39-,40-,41-,48-,49-,50-/m0/ ...
InChI=1S/C19H23ClN2/c1-21(2)12-5-13-22-18-7-4-3-6-15(18)8-9-16-10-11-17(20)14-19(16)22/h3-4,6-7,10-11,14H,5,8-9,12-13H2,1-2H3 ...
InChI=1S/C28H37FN2O/c1-3-5-7-11-19-31(20-12-8-6-4-2)27(32)21-25-24-13-9-10-14-26(24)30-28(25)22-15-17-23(29)18-16-22/h9-10,13-18,30H,3-8,11-12,19-21H2,1-2H3 ...
InChI=1S/C22H25N3O4/c1-28-19-7-3-16(14-20(19)29-2)22(27)25-11-9-24(10-12-25)17-5-6-18-15(13-17)4-8-21(26)23-18/h3,5-7,13-14H,4,8-12H2,1-2H3,(H,23,26) ...
Definition of transferable resistance in the Financial Dictionary - by Free online English dictionary and encyclopedia. What is transferable resistance? Meaning of transferable resistance as a finance term. What does transferable resistance mean in finance?
Although IncP-1 plasmids are important for horizontal gene transfer among bacteria, in particular antibiotic resistance spread, so far only three plasmids from the subgroup IncP-1 alpha have been completely sequenced. In this study we doubled this number. The three IncP-1 alpha plasmids pB5, pB11 and pSP21 were isolated from bacteria of two different sewage treatment plants and sequenced by a combination of next-generation and capillary sequencing technologies. A comparative analysis including the previously analysed IncP-1 alpha plasmids RK2, pTB11 and pBS228 revealed a highly conserved plasmid backbone (at least 99.9% DNA sequence identity) comprising 54 core genes. The accessory elements of the plasmid pB5 constitute a class 1 integron interrupting the parC gene and an IS6100 copy inserted into the integron. In addition, the tetracycline resistance genes tetAR and the ISTB11-like element are located between the klc operon and the trfA-ssb operon. Plasmid pB11 is loaded with a Tn5053-like ...
The molecular nature and replicative behavior of R factor 222 was examined in Proteus mirabilis . In deoxyribonucleic acid (DNA} from R+ P. mirabilis , R factor 222 was identified by CsCl density gradient centrifugation as 2 satellite DNA bands at densities corresponding to 50 and 58 moles percent guanine plus cytosine (% GC) . Replication of the 50 and 58% GC components of R factor 222 in P. mirabilis was analyzed during growth in the presence and absence of chloramphenicol (CAM} and after shifting exponentialand stationary- phase cells to conditions which inhibit host protein or DNA synthesis . CAM reduced the cellular growth rate but increased the amount of both R factor components relative to host chromosomal DNA . However, the 58% GC component showed a larger proportionate increase. This was inferred to indicate reduced synthesis of an inhibitor that acts on both R factor components and an initiator required for replication of the 50% GC component . Replicative patterns observed after shifting
SUMMARY: Transfer of RP4 and related replicons belonging to the Escherichia coli incompatibility group P (Pseudomonas aeruginosa IncP1) to races 2 and 6 of P. syringae pv. pisi was associated with the creation of two types of transconjugant, one resembling the parental race and the other showing an altered cultivar-specificity towards pea. The latter, irrespective of the parental race, exhibited a novel pattern of interaction with pea that corresponded to race 4; consequently such transconjugants were termed race 4-like. Curing of RP4 did not affect the phenotype, except in relation to the antibiotic resistances specified by RP4. The race 4-like strains were non-fluorescent when cultured on appropriate media (in contrast to the particular isolates of races 2 and 6 from which they were derived), showed an enhanced ability to inherit RP4 subsequently (at frequencies up to 10-1 per recipient) and differed from their parental race in their pattern of plasmid profile. The plasmid profiles were similar for
In the PBE lab we study the role of plasmids as catalysts of bacterial evolution, with a special focus on the evolution of plasmid-mediated antibiotic resistance.. Currently, we have two ongoing projects:. - In vivo evolution of plasmid-mediated resistance.. Conjugative plasmids play a key role in the horizontal spread of antibiotic resistance mechanisms among bacteria. One of the key factors undermining the successful spread of a conjugative plasmid is the initial fitness cost produced by the plasmid in the recipient bacteria. The factors involved in this cost and its potential compensation remain largely unknown. In our lab we are trying to understand the evolutionary and genetic determinants that promote the emergence and establishment of successful associations between bacterial clones and resistance plasmids in vivo.. To do so we study conjugation events between different enterobacteria occurring in the gut of hospitalized patients. We study the cost produced by the plasmids when they first ...
In the PBE lab we are interested in the evolutionary forces that drive plasmid dynamics in bacterial populations. Plasmids play a crucial role in bacterial ecology and evolution because they can transfer genes horizontally between different bacteria. The most striking example of how plasmids drive bacterial evolution is the global spread of plasmid-mediated antibiotic resistance over the last few decades. Plasmids are arguably the main vehicle for the spread of antibiotic resistance genes among clinically relevant bacteria, contributing to the overwhelming antibiotic resistance crisis we are currently facing.. In our group we try to understand the population genetics of antibiotic resistance plasmids using advanced molecular and evolutionary techniques. Ultimately, we intend to apply the concepts that we learn from the study of the evolution of plasmid-mediated antibiotic resistance to develop more rational intervention strategies to control infectious diseases.. ...
Individual bacterial cells may contain several different types of plasmids and in some cases more than 10 at a time. Plasmids are generally isolated from the bacterial cells in the supercoiled configuration. So far, thousands of different types of plasmids have been isolated. More than 300 different types of naturally occurring plasmids have been isolated from E.coli alone. Though, plasmids are not considered as part of the cells genome, when a bacterial cell divides each daughter cells receives a copy of each plasmid. Plasmids can also be transferred from one bacterial cell to another by the process called conjugation. Plasmids that govern their own transfer by conjugation are called conjugative plasmids but not all plasmids are conjugative.. ...
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After the development of antimicrobial agents in the 1940s, the notion was prevalent that these drugs would end infectious diseases caused by bacteria. Of course that did not happen, and the reason was the occurrence of antibiotic resistance. Investigations carried out primarily in laboratories in Japan and the United Kingdom in the early 1960s showed that antibiotic resistance in bacteria commonly is associated with the acquisition of genes-often multiple genes-capable of destroying antibiotics or otherwise interfering with their actions. The resistance properties commonly did not map genetically to the bacterial chromosomes, suggesting that the genes encoding resistance were located on separate elements (some had called them episomes) analogous to the fertility factor (F-factor) discovered earlier (12). Like F-factors, resistance factors (R-factors) were capable of being transferred between bacteria by cell-to-cell contact (13, 14). In 1952, Joshua Lederberg had given the name plasmids to ...
The combination of a p15A and a colE1 origin of replication plasmid is the most common two-plasmid system for use in E. coli. The pSB1A* series of plasmids contain the colE1 plasmid and cannot be co-maintained at stable copy numbers in combination due to plasmid incompatibility. Here, two plasmids in the same cell with origins from the same incompatibility group compete for replication machinery, resulting in unpredictable copy number and often the exclusion of one of the plasmids. This is circumvented by cotransforming plasmids with origins from distinct incompatibility groups. Since no p15A origin plasmid was present in the Registry, we developed part J23001, or pSB3C6 for our studies. This plasmid was used for all our riboregulator experiments for the locked-RFP reporter. Shown here is the variant of the plasmid containing part J01022. Plasmids for constructing basic Biobrick parts ...
Enterococcus faecalis is a bacterium found in the intestine of humans as well as in a wide variety of ecological niches. While it is not as virulent as Staphylo...
Dive into the research topics of Site- and strand-specific nicking at oriT of plasmid R100 in a purified system: Enhancement of the nicking activity of tral (helicase I) with traY and IHF. Together they form a unique fingerprint. ...
Plasmid R777-E258 Hs.RASSF3-nostop from Dr. Dominic Espositos lab contains the insert RASSF3. This plasmid is available through Addgene.
InChI:InChI=1S/C27H32F2N8/c1-5-35-8-10-36(11-9-35)16-19-6-7-24(30-14-19)33-27-31-15-22(29)25(34-27)20-12-21(28)26-23(13-20)37(17(2)3)18(4)32-26/h6-7,12-15,17H,5,8-11,16H2,1-4H3,(H,30,31,33,34) ...
InChI=1S/C22H22O12/c1-31-12-3-2-8(13-7-11(25)16-10(24)5-9(23)6-15(16)32-13)4-14(12)33-22-19(28)17(26)18(27)20(34-22)21(29)30/h2-6,13,17-20,22-24,26-28H,7H2,1H3,(H,29,30)/t13?,17?,18-,19+,20?,22+/m0/ ...
InChI=1S/C15H16O10/c16-7-5-6(2-4-9(17)18)1-3-8(7)24-15-12(21)10(19)11(20)13(25-15)14(22)23/h1-5,10-13,15-16,19-21H,(H,17,18)(H,22,23)/b4-2+/t10-,11-,12?,13?,15+/m0/ ...
After freezing and thawing, Pseudomonas aeruginosa harboring a drug resistance plasmid (Hg , Strep ), became acutely sensitive to mercuric ions but not to streptomycin in the plating medium. Its sensitivity to both agents in the plating medium became more pronounced, suggesting a synergistic effect of the mercuric ions with streptomycin. This freeze-thaw-induced sensitivity was transient and capable of being repaired in a simple salts medium (0.5%K2HPO4 + 0.04%MJSO4 pH7.7). Transient wall and membrane damage were also observed in frozen-thawed preparations. From kinetics studies, repair of membrane damage preceded repair of wall damage and damage measured by mercuric ions and mercuric ions plus streptomycin. Osmotically shocked cells also were sensitive to mercuric ions, mercuric ions plus streptomycin and sodium lauryl sulfate, but not to sodium chloride or streptomycin alone. This sensitivity was transient and capable of repair in the same simple salts medium. Active transport of a ...
SUMMARY. Trimethoprim-resistant urinary isolates of Escherichia coli, collected in 1982, were studied and the results compared with those obtained for isolates collected during the period 1979-1980. Ninety-eight (81%; a 10% increase) were resistant to trimethoprim 1024 μg/ml and 93 (95%) were also resistant to sulphamethoxazole 1024 μg/ml. The frequency distributions of plasmids were similar in both collections although there was a significant increase in the number of small plasmids (mol. wt ≤ 20 x 106) in the 1982 collection. Transfer of resistance was associated with isolates that carried larger numbers of plasmids. A significantly smaller proportion of isolates in this, than in the earlier series, transferred trimethoprim resistance to E. coli K12 suggesting continued transposition of trimethoprim resistance on to the bacterial chromosome. Fifteen different trimethoprim resistance plasmids were identified, of which five, including that found most frequently, were common to both collections.
Molecular Characterization of the R Factors Implicated in the Carbenicillin Resistance of a Sequence of Pseudomonas aeruginosa Strains Isolated from Burns: An o
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Plasmid psbA2-Ptrc-PHLS (d) from Dr. Anastasios Meliss lab contains the inserts beta-phellandrene synthase and Chloramphenicol resistance and is published in Planta May 2014 This plasmid is available through Addgene.
SB> As Ian Miller said, please send an email SB> to [email protected] regarding SB> this issue. You may get some useful SB> assistance. Why be so
Here is an example of Complete filtering based on a factor: The droplevels() function removes unused levels of factor variables from our dataset.
Canonical SMILES: CN1CCN(CC1)CCOC2=CC(=C3C(=C2)N=CN=C3NC4=C(C=CC5=C4OCO5)Cl)OC6CCOCC6. InChI: InChI=1S/C27H32ClN5O5/c1-32-6-8-33(9-7-32)10-13-35-19-14-21-24(23(15-19)38-18-4-11-34-12-5-18)27(30-16-29-21)31-25-20(28)2-3-22-26(25)37-17-36-22/h2-3,14-16,18H,4-13,17H2,1H3,(H,29,30,31). InChI Key: OUKYUETWWIPKQR-UHFFFAOYSA-N ...
Canonical SMILES: CN1CCN(CC1)CCOC2=CC(=C3C(=C2)N=CN=C3NC4=C(C=CC5=C4OCO5)Cl)OC6CCOCC6. InChI: InChI=1S/C27H32ClN5O5/c1-32-6-8-33(9-7-32)10-13-35-19-14-21-24(23(15-19)38-18-4-11-34-12-5-18)27(30-16-29-21)31-25-20(28)2-3-22-26(25)37-17-36-22/h2-3,14-16,18H,4-13,17H2,1H3,(H,29,30,31). InChI Key: OUKYUETWWIPKQR-UHFFFAOYSA-N ...
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InChI=1S/C23H45N5O14.H2O4S/c24-2-7-13(32)15(34)10(27)21(37-7)41-19-9(4-30)39-23(17(19)36)42-20-12(31)5(25)1-6(26)18(20)40-22-11(28)16(35)14(33)8(3-29)38-22;1-5(2,3)4/h5-23,29-36H,1-4,24-28H2;(H2,1,2,3,4)/t5-,6+,7+,8-,9-,10-,11-,12+,13-,14-,15-,16-,17-,18-,19-,20-,21-,22-,23+;/m1./s1 ...
There are two distinct factors: Extrinsic factor, much more commonly known as vitamin B12 Intrinsic factor, a glycoprotein ... Castle (gastric) factors, named after the American physician and physiologist W. B. Castle, are biologically active chemical ... is necessary for the absorption of vitamin B12 This disambiguation page lists articles associated with the title Castle factors ...
... differ from static factors, such as building floor areas, which determine energy consumption but change only ... What these examples all have in common is that on a weekly basis (say) numerical values can be recorded for each factor and one ... One of the most common driving factors is the weather, expressed usually as heating or cooling degree days. In energy-intensive ... Variation in the driving factor merely has to explain variation in consumption; it does not necessarily have to cause it, ...
... , also commonly spelled Factor's Walk or Factors' Walk, is a historic street in Savannah, Georgia, United States. ... Thus, Factors Walk evolved as a much more free-flowing passageway for factors and business owners to utilize. Initially used by ... Factors Walk" - Savannah.com "Where the colony of Georgia began" - savannahswaterfront.com Factors Walk - Savannah Construction ... A factor is a type of trader who receives and sells goods on commission. In most cases in Savannah, the goods were King Cotton ...
The CNTF family of neurotrophic factors includes ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), ... glia maturation factor, insulin, insulin-like growth factor 1 (IGF-1), vascular endothelial growth factor (VEGF), fibroblast ... Most neurotrophic factors belong to one of three families: (1) neurotrophins, (2) glial cell-line derived neurotrophic factor ... "Neurotrophic factors". Nature Publishing Group. Retrieved 31 May 2016. Neurotrophic factors are molecules that enhance the ...
Endothelial cells possess tissue-specific genes that code for unique growth factors, adhesion molecules and factors regulating ... Angiocrine growth factors are molecules found in blood vessels' endothelial cells that can stimulate organ-specific repair ...
Joel Weinberger and Cristina Rasco listed five common factors in 2007 and reviewed the empirical support for each factor: the ... In 1990, Lisa Grencavage and John C. Norcross reviewed accounts of common factors in 50 publications, with 89 common factors in ... There are several criticisms of common factors theory, for example: that common factors theory dismisses the need for specific ... Grencavage and Norcross grouped common factors into five areas in 1990. Lambert formulated four groups of therapeutic factors ...
According to the Journal Citation Reports, the journal has a 2019 impact factor of 3.165. "Human Factors". 2019 Journal ... Human Factors is a peer-reviewed academic journal that publishes scientific studies in ergonomics. The editor-in-chief is ... It was established in 1958 and is published by SAGE Publications in association with the Human Factors and Ergonomics Society. ... Articles with outdated impact factors from 2017, Official website different in Wikidata and Wikipedia, SAGE Publishing academic ...
Klf5 activates the promoter of the hypertrophic agonist platelet derived growth factor (PDGFA) in cardiac fibroblasts a factor ... Such cross-regulation occurs extensively in transcription factor families. Many transcription factor genes regulate their own ... Kruppel-like+transcription+factors at the US National Library of Medicine Medical Subject Headings (MeSH) Generating iPS Cells ... KLF4] is one of the so-called magic four transcription factors, KLF4, Oct4, Sox2 and Myc. KLF5, like KLF3, is important in ...
The Colors X-Factors (Nepali: कलर्स एक्स-फ्याक्टर्स) is a cricket team that represents in the Nepal Premier League. Gyanendra ... "EPL : Colors X factor failed to lift the trophy, Retrieved 30 September 2020 v t e (Articles with short description, Short ...
The Method of Factors is a technique in cognitive behavioral therapy to organise a session of exposure therapy. Rather than ... the Method of Factors involves identifying a fear-provoking stimulus, then identifying those features of the stimulus that ...
... (MRF) are basic helix-loop-helix (bHLH) transcription factors that regulate myogenesis: MyoD, Myf5 ... Myogenic+Regulatory+Factors at the US National Library of Medicine Medical Subject Headings (MeSH) (Articles with short ... Hernández-Hernández J, García-González E, Brun C, Rudnicki M (2017). "The myogenic regulatory factors, determinants of muscle ... of an Independent Amphioxus Expansion and Two-Gene Ancestral Vertebrate State for MyoD-Related Myogenic Regulatory Factors ( ...
... but archaeal initiation factors are seen to have both traits of eukaryotic and prokaryotic initiation factors. Two core TIFs, ... Actually an elongation factor. aIF5B: IF2/eIF5B homolog. Join the ribosomal subunits (small and large) to form the complete ... Archaeal initiation factors are proteins that are used during the translation step of protein synthesis in archaea. The ... Rossi, D; Kuroshu, R; Zanelli, CF; Valentini, SR (2013). "eIF5A and EF-P: two unique translation factors are now traveling the ...
Growth Factors is a bimonthly peer-reviewed scientific journal that covers research on the control of cell production and ... Growth factors, Taylor & Francis academic journals, English-language journals, Bimonthly journals, All stub articles, Molecular ...
... different transcriptional factor and sigma factor interact with their correspondent anti-sigma factor. Third, anti-sigma factor ... Each sigma factor has an associated anti-sigma factor which regulates it. These anti-sigma factors are divided into either ... anti-sigma factors bind to sigma factors and inhibit transcriptional activity. Anti-sigma factors have been found in a number ... anti-sigma factor inhibit the sigma factor by confinement. In prokaryotes, E. coli has seven different sigma factors depends on ...
... common usage Factor payments Factor market Factor world Labor demand Labor theory of value Labour economics Marginal factor ... While Douglas did not deny the role of these factors in production, he considered the "Cultural heritage" as the primary factor ... Sometimes the overall state of technology is described as a factor of production. The number and definition of factors vary, ... There are four basic resources or factors of production: land, labour, capital and entrepreneur (or enterprise). The factors ...
The Kagyu E-Vam Buddhist Institute.[1] Wikiquote has quotations related to Mental factors (Buddhism). Mahayana mental factors: ... Within this system, the Abhidharma-samuccaya identifies fifty-one mental factors: The five universal mental factors (sarvatraga ... Berzin Mind and Mental Factors by Venerable Thubten Chodron Rigpa wiki entry for mental factors Theravada mental factors: ... concentration The five factors are referred to as object-determining is because these factors each grasp the specification of ...
Media related to Interferon regulatory factors at Wikimedia Commons Interferon+regulatory+factors at the US National Library of ... Interferon regulatory factors (IRF) are proteins which regulate transcription of interferons (see regulation of gene expression ... For instance, the remaining parts of the interferon regulatory factor sequence vary depending on the precise function of the ... Zhao GN, Jiang DS, Li H (February 2015). "Interferon regulatory factors: at the crossroads of immunity, metabolism, and disease ...
In molecular biology, the GCM transcription factors are a family of proteins which contain a GCM motif. The GCM motif is a ... Schreiber J, Sock E, Wegner M (April 1997). "The regulator of early gliogenesis glial cells missing is a transcription factor ... In GCM transcription factors the N-terminal moiety contains a DNA-binding domain of 150 amino acids. Sequence conservation is ...
These friction factors were first calculated by Jean-Baptiste Perrin. These factors pertain to spheroids (i.e., to ellipsoids ... The rotational friction factors are rarely observed directly. Rather, one measures the exponential rotational relaxation(s) in ... For brevity in the equations below, we define the Perrin S factor. For prolate spheroids (i.e., cigar-shaped spheroids with two ... In hydrodynamics, the Perrin friction factors are multiplicative adjustments to the translational and rotational friction of a ...
Retrieved April 10, 2021.{{cite web}}: CS1 maint: url-status (link) Human Factors at IMDb Human Factors at Rotten Tomatoes (CS1 ... Human Factors is a German-Italian-Danish co-production drama film directed and written by Ronny Trocker. The film stars Mark ... Rose, Virginia (December 17, 2020). "Sundance 2021: Human Factors, the brand-new movie by South Tyrolean Ronny Trocker on the ... "Film and TV Projects Going Into Production - Human Factors". Variety Insight. Archived from the original on March 24, 2021. ...
... (HFI) is the process adopted by a number of key industries (notably defence and hazardous industries ... Ergonomics Human Factors Integration Defence Technology Centre UK Ministry of Defence Policy, information and guidance on the ... The purpose of the HFIP is to define how the Human Factors Engineering activities necessary for the successful delivery of a ... It establishes the guiding principles to be followed by the project to implement the best-practice Human Factors methods. As ...
Hepatocyte nuclear factor 1A bound to DNA [1] Different rendering of HNF1a bound to DNA Hepatocyte+Nuclear+Factors at the US ... Hepatocyte nuclear factors (HNFs) are a group of phylogenetically unrelated transcription factors that regulate the ... Ryffel GU (2001). "Mutations in the human genes encoding the transcription factors of the hepatocyte nuclear factor (HNF)1 and ... Hence hepatocyte nuclear factors function to ensure liver specific expression of certain genes. As is the case with many ...
45 Factors of the Seven at AllMusic Rimmer, Mike (August 1, 1997). "Review: Factors of the Seven - Grits". Cross Rhythms. ... Factors of the Seven is the second studio album released by GRITS, in 1998. Awarding the album a ten from Cross Rhythms, Mike ... "The Grits :: Factors of the Seven :: Gotee Records". Rap Reviews. Retrieved February 2, 2016. v t e v t e (Articles with short ... Anderson, Patrick (October 24, 2007). "Grits, "Factors of the Seven" Review". Jesus Freak Hideout. Retrieved February 2, 2016. ...
... prenatal environment and possibly medication and socioeconomic factors. References for many of these environmental risk factors ... An environmental risk factor may act alone or in combination with others. Schizophrenia typically develops between the ages of ... "Social factors 'cause ethnic schizophrenia'". BBC News. 22 June 2002. MacMillan HL, Fleming JE, Streiner DL, Lin E, Boyle MH, ... Risk factors of schizophrenia at Curlie "Schizophrenia". National Institute of Mental Health. (CS1 maint: DOI inactive as of ...
The effect of receiving a certain dose of radiation (given as Gy) is variable and depends on many factors, thus a new unit was ... This article give a list of conversion factors for several physical quantities. A number of different units (some only of ... and Q is a dimensionless quality factor. Thus, for any quantity of D measured in Gy, the numerical value for H measured in Sv ...
... is a historic building in Savannah, Georgia, United States. The building dates to 1889, when a three-year ... passing over East Factors Walk. It is now Olde Harbour Inn. Tide Water Oil Company leased two floors of the new building, but ...
HIV is a major risk factor for tuberculosis. The risk of developing TB is estimated to be between 20 and 37 times greater in ... There are a number risk factors for tuberculosis infection; worldwide the most important of these is HIV. Co-infection with HIV ... Strachan DP, Powell KJ, Thaker A, Millard FJ, Maxwell JD (February 1995). "Vegetarian diet as a risk factor for tuberculosis in ... Diabetes mellitus is also an important risk factor that is growing in importance in developing countries. Other disease states ...
These risk factors include: Common risk factors: Situation of armed conflict or other forms of instability Record of serious ... The United Nations have their list of 14 risk factors for atrocity crimes with multiple indicators for each factor. ... atrocity crimes Absence of mitigating factors Enabling circumstances or preparatory action Triggering factors Risk factors ... If a nation has one or more of these risk factors it does not mean that they will have a genocide but they are simply additive ...
The factors σ ω , ℓ , m {\displaystyle \sigma _{\omega ,\ell ,m}} are called the greybody factors of the black hole. For a ... The greybody factors can be computed by a classical scattering computation of a wave-packet off the black hole. The rate at ... Black hole greybody factors are functions of frequency and angular momentum that characterizes the deviation of the emission- ... This deviation is captured by the greybody factors. The name "greybody" is simply meant to indicate the difference of the ...
FOX proteins Winged-Helix+Transcription+Factors at the US National Library of Medicine Medical Subject Headings (MeSH) v t e ( ... Consisting of about 110 amino acids, the domain in winged-helix transcription factors (see Regulation of gene expression) has ... Articles with short description, Short description matches Wikidata, Transcription factors, All stub articles, Genetics stubs) ...
Learn more about stroke risk factors from the CDC. ... Stroke risk factors include age and behaviors such as smoking. ... Genetic factors likely play some role in high blood pressure, stroke, and other related conditions. Several genetic disorders ... Trends in stroke hospitalizations and associated risk factors among children and young adults, 1995-2008. Annals of Neurology. ... People with a family history of stroke are also likely to share common environments and other potential factors that increase ...
Factor V Leiden (FAK-tur five LIDE-n) is a mutation of one of the clotting factors in the blood. This mutation can increase ... The factor V Leiden mutation does not itself cause any symptoms. Since factor V Leiden is a risk for developing blood clots in ... Risk factors. A family history of factor V Leiden increases your risk of inheriting the disorder. The disorder is most common ... Both men and women can have factor V Leiden. Women who carry the factor V Leiden mutation may have an increased tendency to ...
What is an important factor to consider before deciding whether or not to give them one? Why is this factor so important?" ... 10 Key Factors in Determining Whether an Employee Should Get a Raise. Published: May 28, 2020 Last Updated: Aug 23, 2022 by The ... Look at these factors to determine if they should get a raise." ~ John Rampton, Calendar ... but there are other factors to consider as well. Thats why we asked 10 entrepreneurs from Young Entrepreneur Council (YEC) the ...
Risk Factors for Type 2 Violence Unit 4: Risk Factors for Type 3 Violence Unit 5: Prevention Strategies for Organizations Unit ... Unit 4: Risk Factors for Type 3 Violence Workplace Violence Prevention for Nurses About This Course Unit 1: Definitions, Types ... Contributing Factors. The Joint Commission has acknowledged that "intimidating and disruptive behaviors" among co-workers in ... "Systemic factors stem from the unique health care cultural environment, which is marked by pressures that include increased ...
... dc.contributor.author. World Health Organization. en_US. dc.contributor.author. Expert Committee on Epidemiology ...
This suggests that a certain proportion of VTE previously considered as idiopathic might be due to such factors as obesity, ... A new meta-analysis shows that some cardiovascular risk factors are significantly associated with an increased risk of venous ... Given the multifactorial nature of VTE, it is highly likely that these risk factors for atherothrombosis possibly work together ... Although it was already recognized that obesity is a mild risk factor for VTE, the evidence for other risk factors was flimsy. ...
A risk factor is something that increases your chance of getting a disease or health problem. Some risk factors for stroke you ... Risk factors are things that increase your chance of getting a disease or condition. This article discusses the risk factors ... Some risk factors for stroke that you can change are:. *Not smoking. If you do smoke, quit. Ask your health care provider for ... Changing the risk factors that you have control over will help you live a longer, healthier life. ...
Account for these factors when estimating site-specific doses. In addition, some people, such as asthmatics or the elderly, ... Before excluding a contaminant from further evaluation, be sure to consider these other factors:. *Community concerns. As ... The In-Depth Toxicological Effects Analysis section expands on how you should weigh these factors in your evaluation of site ... This section explains the other factors health assessors need to consider during the EPC and exposure calculation process ...
Addressing cardiovascular diseases through risk-factor reduction: round table2  Regional Committee for Africa, 52 (‎World ... Alcohol is a global risk factor for disease, and Europe is the heaviest-drinking region in the world. Research has shown a ... Alcohol consumption has long been recognized as one of the main driving factors of mortality in the Russian Federation, ...
Risk Factor Assessment Tools. Falls are due to many factors, and a holistic approach to the individual and environment is ... Well supported tool that identifies risk factors and creates a risk profile score. Used to identify clinical fall risk factors ... The MFS requires systematic, reliable assessment of a clients fall risk factors upon admission, after a fall, with a change in ... A number of assessment tools are readily available to identify adults fall risk factors. Several tools can be used with ...
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Pathologic factors that affect survival. Pathologic factors that impact survival include the following:. * Tumor extension - In ... Clinical factors that affect survival. These include the following:. * Length of time from initial radiation therapy to ... Risk Factors. The etiology of vaginal cancer has not been identified. Note that vaginal cancer is not histologically ... Factors affecting risk of mortality in women with vaginal cancer. Obstet Gynecol. 2009 May. 113(5):1038-45. [QxMD MEDLINE Link] ...
They can be caused by several factors, including the weather, licking your lips too much, and even taking certain medications. ... Keloids and hypertrophic scars are similar in many ways but differ in their risk factors, treatment, and outlook. ...
Here are some factors that may affect Middle East stock markets on Wednesday. ... DUBAI - Here are some factors that may affect Middle East stock markets on Wednesday. Reuters has not verified the press ... Here are some factors that may affect Middle East stock markets on Wednesday. ...
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What are some of the success factors these programs identify?. Consistency. "Consistency is so important! If youre not ...
1. Factors Affecting Reserve Balances of Depository Institutions (continued) Millions of dollars Reserve Bank credit, related ... FEDERAL RESERVE statistical release H.4.1 Factors Affecting Reserve Balances of Depository Institutions and Condition Statement ... Total factors supplying reserve funds 4,507,157 - 6,995 + 8,808 4,502,772 Note: Components may not sum to totals because of ... Total factors, other than reserve balances, absorbing reserve funds 2,263,942 - 6,377 - 126,420 2,221,300 Reserve balances with ...
Get the latest power factor correction info from our tech-obsessed editors with breaking news, in-depth reviews, hands-on ...
World Health Organization, Expert Committee on Epidemiology of Onchocerciasis & Buck, A. A. (‎1975)‎. Host factors. Expert ...
Charlie Demerjian is the founder of Stone Arch Networking Services and S,A. SemiAccurate.com is a technology news site; addressing hardware design, software selection, customization, security and maintenance, with over one million views per month. He is a technologist and analyst specializing in semiconductors, system and network architecture.. As head writer of SemiAccurate.com, he regularly advises writers, analysts, and industry executives on technical matters and long lead industry trends. Charlie is also available through Guidepoint and Mosaic.. Thomas Ryan is a GIS Programmer and freelance technology writer from Seattle, WA. You can find his work on SemiAccurate and PCWorld.. ...
Limiting factors can be single elements or a group of related factors. Source for information on Limiting Factors: The Gale ... Limiting Factors Limiting factors are environmental influences that constrain the productivity of organisms, populations, or ... Factor Viii , Factor VIII (antihaemophilic factor) One of the blood clotting factors. Factor VIII is a soluble protein that ... Limiting Factor , Limiting factor Limiting factors are environmental influences that constrain the productivity of organisms, ...
Many factors can reduce risk for suicide. Similar to risk factors, a range of factors at the individual, relationship, ... Societal Protective Factors:. These cultural and environmental factors within the larger society protect against suicide risk: ... Many factors contribute to suicide risk.. Suicide is rarely caused by a single circumstance or event. Instead, a range of ... These risk factors are situations or problems that can increase the possibility that a person will attempt suicide. ...
This handout helps outline the most common risk factors associated with HIV/AIDS, as well as best practices for risk reduction. ...
Certain risk factors may increase your chance of developing gallbladder cancer. This guide will help you learn about possible ... Risk Factors for Gallbladder Cancer. A risk factor is anything that affects your chance of getting a disease such as cancer. ... Other possible risk factors. Studies have found other factors that might increase the risk of gallbladder cancer, but the links ... But having a risk factor, or even many risk factors, doesnt mean that a person will get the disease. And many people who get ...
Learn about the factors that make morganite so desirable. ... Explore morganite history, research, quality factors, and more ...
Factor became a United States citizen in 1916. In 1920, Max Factor gave in to Frank Factors suggestion, and officially began ... Davis Factor (February 2, 1902 - August 31, 1991). *Francis "Frank" Factor (later known as Max Factor Jr.; August 18, 1904 - ... "Max Factor House , Los Angeles Conservancy". www.laconservancy.org. Retrieved 2018-11-19. Factor, born to a Jewish family in ... Additionally, Max Factor is honored with a star on the Hollywood Walk of Fame (at 6922 Hollywood Boulevard). Max Factor is ...
View Dell OptiPlex 3000 Desktop Small Form Factor desktop computer with new Hybrid Core technology or shop all Dell Optiplex ... Model: 3000 Small Form Factor EXPLORE OTHER MODELS 3000 Micro 3000 Small Form Factor 3000 Thin Client 3000 Tower 3090 Ultra ... Small Form Factor:. Front: 2 USB 2.0 ports. 2 USB 3.2 Gen 1 ports. 1 universal audio jack. Rear:. 2 USB 3.2 Gen 1 ports. 2 USB ... Small Form Factor:. 1 half-height Gen 4 PCIe x16 slot. 1 half-height Gen 3 PCIe x1 slot. 1 M.2 2230 slot for WiFi and Bluetooth ...
Family health history is a non-modifiable risk factor-or is it?. "I met three different women who had been tested [genetic ... risk factors - Genomics and Precision Health Blog ...
  • Data sources include CDC's Behavioral Risk Factor Surveillance System , CDC's Population Level Analysis and Community Estimates (PLACES) Project, and the U.S. Census Bureau external icon . (cdc.gov)
  • The Expanded Risk Factor Surveillance System (Expanded BRFSS) augments the CDC Behavioral Risk Factor Surveillance System (BRFSS) , which is conducted annually in New York State. (ny.gov)
  • Retrieved on November 29, 2022 from https://www.news-medical.net/health/Pneumonia-Symptoms-Risk-Factors.aspx. (news-medical.net)
  • Mitterstieler G, Muller W, Geir W. Congenital factor V deficiency. (medscape.com)
  • Shirzadi M, Radfar AH, Dehghani M. Recurrent miscarriage in a woman with congenital factor V deficiency: a case report. (medscape.com)
  • Although it was already recognized that obesity is a mild risk factor for VTE, the evidence for other risk factors was flimsy. (medscape.com)
  • What is a Risk Factor? (medlineplus.gov)
  • A risk factor is something that increases your chance of getting a disease or health problem. (medlineplus.gov)
  • Alcohol is a global risk factor for disease, and Europe is the heaviest-drinking region in the world. (who.int)
  • It is a major risk factor for non-communicable diseases (NCDs) including cardiovascular disease, chronic respiratory disease, diabetes and cancer4. (who.int)
  • A risk factor is anything that affects your chance of getting a disease such as cancer. (cancer.org)
  • But having a risk factor, or even many risk factors, doesn't mean that a person will get the disease. (cancer.org)
  • Gallstones are the most common risk factor for gallbladder cancer. (cancer.org)
  • Obesity is also a risk factor for gallstones, which might help explain this link. (cancer.org)
  • Family health history is a non-modifiable risk factor-or is it? (cdc.gov)
  • Physical inactivity is a key modifiable risk factor for prediabetes and Type 2 diabetes. (heart.org)
  • When discussing common risk factors associated with leukemia and other cancers, it is important to understand that a risk factor is only something that indicates the potential for an increased risk of developing the condition. (moffitt.org)
  • And while obesity is considered a critical risk factor for adenocarcinoma, alcohol use is not. (curetoday.com)
  • And though not as strong a risk factor as smoking, research shows that long-term heavy drinking increases a person's risk of developing squamous cell carcinoma. (curetoday.com)
  • Lifestyle risk factor data on the Tracking Network can be used by public health professionals to determine if certain health outcomes are related to the environment or if they could also be due to lifestyle risk factors such as smoking and lack of physical activity. (cdc.gov)
  • The Tracking Network hosts the following lifestyle risk factor data. (cdc.gov)
  • There are several risk factors that increase a person's chance of acquiring a pneumonia infection. (news-medical.net)
  • Certain risk factors may increase a person's chances of developing ocular melanoma. (medicalnewstoday.com)
  • Environmental factors must satisfy minimum and maximum criteria for life. (encyclopedia.com)
  • The minimal criteria for metabolically essential environmental factors represent the least availability that will sustain organisms or ecological processes, while the maxima represent toxicity or other biological damages. (encyclopedia.com)
  • The minimum and maximum levels of environmental factors bound a relatively broad range within which there are optimal levels at which factors exert no constraints on biological productivity. (encyclopedia.com)
  • The potential limitations by particular environmental factors are best studied by doing experiments, preferably in the field. (encyclopedia.com)
  • Limitations by toxic environmental factors can sometimes be studied by transplanting organisms into cleaner environments, for example, away from a place that is polluted by sulfur dioxide . (encyclopedia.com)
  • Researchers believe that it may result from a combination of genetic and environmental factors. (medicalnewstoday.com)
  • Scientists from the International Agency for Research on Cancer (IARC) participated in a study of environmental factors and declining human fertility led by researchers from the Department of Growth and Reproduction at Copenhagen University Hospital in Denmark. (who.int)
  • Zheng C, Zhang B. Combined deficiency of coagulation factors V and VIII: an update. (medscape.com)
  • Several factors are behind substance use, such as low socioeconomic status, unstructured time with peers, parental influences, psychosocial factors and community factors (2). (who.int)
  • The present work proposes to analyze the theoretical models about occupational stress and psychosocial factors. (bvsalud.org)
  • For this, we will present approaches that study the occupational stress and the psychosocial factors in the labor environment. (bvsalud.org)
  • In this article, therefore, we will present the principal models that discuss psychosocial factors and occupational stress: job-demand-control, job demand control support model, effort-reward imbalance model, ecological model and the National Institute for Occupational and Health (NIOSH) proposal. (bvsalud.org)
  • Factor V Leiden can cause blood clots in the legs (deep vein thrombosis) and lungs (pulmonary embolism). (mayoclinic.org)
  • Topics assessed by the Expanded BRFSS include tobacco use, physical inactivity, diet, use of cancer screening services, and other factors linked to the leading causes of morbidity and mortality. (ny.gov)
  • Note that any integer content (see first example below) is not factored. (maplesoft.com)
  • In diabetics,high urine glucose content and defective host immune factors predispose to infection. (medscape.com)
  • Im Herbst 2021 wurde bekannt, dass es neue Geschichten von X-Factor: Das Unfassbare geben wird. (wikipedia.org)
  • Google's goal is to automatically enroll 150 million user accounts to start using its two-factor authentication security process by the end of 2021, which requires people to sign in using a password and confirm their identity on another device via a "Google Prompt" - commonly done on a smartphone. (laptopmag.com)
  • Lifestyle related risk factors such as tobacco use, harmful use of alcohol, unhealthy diet, and insufficient physical activity are known modifiable contributors to non-communicable diseases (NCDs) and mental health issues2. (who.int)
  • These are called modifiable risk factors. (heart.org)
  • Those that you can't change are non-modifiable risk factors. (heart.org)
  • You can - and should - do something about your modifiable risk factors. (heart.org)
  • Diet is one of the most important modifiable risk factors for prediabetes and Type 2 diabetes. (heart.org)
  • The data can also be used by public health officials to determine the best public health actions to reduce modifiable lifestyle risk factors in their communities. (cdc.gov)
  • Estimates indicate that approximately one half of all cancer cases either arise from modifiable risk factors or can be detected as precursor lesions before the development of disease with metastatic potential. (medscape.com)
  • Combinations of modifiable and nonmodifiable risk factors place some people at particularly high risk for cancer. (medscape.com)
  • The factor V Leiden mutation does not itself cause any symptoms. (mayoclinic.org)
  • However, it can be helpful to have a basic understanding of the most common contributing factors that can make a person more susceptible to the disease so that individuals at risk can be proactive about living a healthy lifestyle and vigilant of signs and symptoms. (moffitt.org)
  • Searchmetrics has released their SEO ranking factors for Bing, Microsoft's search engine, today. (searchengineland.com)
  • Similar to their Google ranking factors, Searchmetrics analyzed 10,000 popular keywords and 300,000 websites appearing in the top 30 search results and looked at how various factors correlated with rankings. (searchengineland.com)
  • Sociodemographic factors, socioeconomic status, and type of insurance coverage have a substantial impact on the elderly population's access to health care. (uspharmacist.com)
  • But if patients are obese or hypertensive or have diabetes, then the VTE should not be considered as idiopathic but related to the presence of cardiovascular risk factors," he says. (medscape.com)
  • But patients with VTE receive short- to medium-term anticoagulation, and usually they are not studied for cardiovascular risk factors. (medscape.com)
  • They subsequently analyzed all of these old studies that assessed one or more cardiovascular risk factors in patients with VTE, all of which had control groups. (medscape.com)
  • During January-March 2014, we reviewed risk factors CMRs were lower, but still substantial, for patients receiv- for dissemination and summarized all coccidioidomycosis ing steroids (https://www.niaid.nih.gov/sites/default/files/ cases in patients with primary immunodeficiency (PID). (cdc.gov)
  • Patients with exogenous immunosuppres- consideration of underlying host genetic factors. (cdc.gov)
  • Delev D, Pavlova A, Heinz S, Seifried E, Oldenburg J. Factor 5 mutation profile in German patients with homozygous and heterozygous factor V deficiency. (medscape.com)
  • Girolami A, Scandellari R, Lombardi AM, Girolami B, Bortoletto E, Zanon E. Pregnancy and oral contraceptives in factor V deficiency: a study of 22 patients (five homozygotes and 17 heterozygotes) and review of the literature. (medscape.com)
  • We've invested more than $5 billion in cancer research since 1946, all to find more - and better - treatments, uncover factors that may cause cancer, and improve cancer patients' quality of life. (cancer.org)
  • The analysis found that in about 1 in 5 cases, shortcomings in the quality of care and other factors beyond patients' control explain why they leave the hospital before completing recommended treatment. (medscape.com)
  • 11 A factor in patients' perceptions of clinicians' responsiveness may be their ability to make patients feel respected and understood regardless of cultural differences between them. (uspharmacist.com)
  • This measure enabled independent investigation of potential risk factors for infection, such as frequency of classroom ventilation and classroom space, for each of the case-patients and controls. (cdc.gov)
  • Therefore, the authors of this research brief undertook an exploratory analysis of the relationship between readily available clinical factors and target ulcer healing within 6 months from the first date of service (first clinic visit) in patients with ulcerative PG. (medscape.com)
  • This study aimed to assess the incidence of pulmonary embolism and associated factors among confirmed Covid-19 Patients in Ethiopia . (bvsalud.org)
  • This study investigated the characteristics of patients with skin and soft tissue infections (SSTIs) caused by nontuberculous mycobacteria (NTM) and identified the risk factors for treatment failure in these patients . (bvsalud.org)
  • The In-Depth Toxicological Effects Analysis section expands on how you should weigh these factors in your evaluation of site exposures and determining public health implications. (cdc.gov)
  • Factor exposures are calculated 12 months prior to the total-return period. (msci.com)
  • Analyst Shaw Wu has stated that supply chain checks indicate signs of new form factor iPhones under development, including both larger and smaller touchscreens than the iPhone 4's current 3.5-inch screen size. (macrumors.com)
  • AMD's DTX small form factor specification has progressed since the announcement in January 2007. (madshrimps.be)
  • AMD's DTX Form Factor: Smaller PCs for Everyone? (madshrimps.be)
  • Parahemophilia: new insights into factor v deficiency. (medscape.com)
  • Acquired factor V deficiency in a patient with myeloma and amyloidosis. (medscape.com)
  • Duckers C, Simioni P, Rosing J, Castoldi E. Advances in understanding the bleeding diathesis in factor V deficiency. (medscape.com)
  • Asselta R, Peyvandi F. Factor V deficiency. (medscape.com)
  • Familial coagulation factor V deficiency caused by a novel 4 base pair insertion in the factor V gene: factor V Stanford. (medscape.com)
  • A novel homozygous mutation (Gly1715Ser) causing hereditary factor V deficiency in a Chinese patient. (medscape.com)
  • Alsheikh S, Alghamdi R, Alqatari A, Alfareed A, AlSaleh M. Combined Factor V and VIII Deficiency with LMAN1 Mutation: A Report of 3 Saudi Siblings. (medscape.com)
  • Acquired factor V deficiency in a patient with a urinary tract infection presenting with haematuria followed by multiple haemorrhages with an extremely low level of factor V inhibitor: a case report and review of the literature. (medscape.com)
  • A case of unusual acquired factor V deficiency. (medscape.com)
  • Totan M, Albayrak D. Intracranial haemorrhage due to factor V deficiency. (medscape.com)
  • The sociodemographic and health behaviour factors that were significantly related to early mean age of menopause were: never married (44.7 years), low income level (47.4 years), low social class (45.8 years), tobacco use (47.9 years) and non-consanguineous husband (48.1 years). (who.int)
  • Therefore, pharmacists and other clinicians must continue to strive for effective communication with sensitivity toward cultural, socioeconomic, and sociodemographic factors. (uspharmacist.com)
  • 2-6 Some sociodemographic factors such as race and income are highly correlated with a lack of insurance in younger populations. (uspharmacist.com)
  • Multi-Factor Authentication (MFA) is a critical cybersecurity tool used to confirm your identity and helps prevent hackers from gaining access to your personal information and NYU's network. (nyu.edu)
  • Google announced it will force users to use two-factor authentication to sign in earlier this year, and the tech giant is honoring its word by auto-enrolling people to use its 2-Step Verification (2SV) process. (laptopmag.com)
  • Multi-factor authentication (MFA) is a digital authentication method used to confirm the identity of a user to allow them access to a website or app through at least two pieces of evidence. (laptopmag.com)
  • Two-factor authentication (2FA), which Google calls 2VS, is the most commonly used method. (laptopmag.com)
  • As you'll find in our PSA about two-factor authentication , malicious hackers can easily use 2FA against users that use their phone numbers. (laptopmag.com)
  • For the best way to use two-factor authentication, check out our guide on how to do 2FA right . (laptopmag.com)
  • Whether it's connecting Scar from The Lion King to two-factor authentication or turning his love for gadgets into a fabricated rap battle from 8 Mile, he believes there's always a quirky spin to be made. (laptopmag.com)
  • This statistic presents the results of 2017 survey, in which consumers in the Republic of Ireland were asked which of the selected external factors they think will most impact their spending. (statista.com)
  • FEDERAL RESERVE statistical release H.4.1 Factors Affecting Reserve Balances of Depository Institutions and Condition Statement of Federal Reserve Banks November 2, 2017 1. (federalreserve.gov)
  • The GPIF are leading on sustainable investment in Japan, having introduced ESG factors into their equity portfolio in 2017. (worldbank.org)
  • The research has important clinical implications, he says, because a significant proportion of VTE, up to 47%, is currently classed as unprovoked in the absence of major known risk factors, such as cancer, trauma, and surgery. (medscape.com)
  • This exploratory analysis investigated the relationship between readily available clinical factors and target ulcer healing within 6 months from the first visit. (medscape.com)
  • Having chest pain was found to be a significant factor that indicates the development of PE, implying that in a setting where performing upfront CTPA is not practical, detailed symptom inquiry could serve as an important clinical criteria. (bvsalud.org)
  • Here you'll find in-depth information on specific cancer types - including risk factors, early detection, diagnosis, and treatment options. (cancer.org)
  • Australia's cricketers have lost their "fear factor" and could be heading towards a West Indies-style decline, batting great Brian Lara has warned. (thedailystar.net)
  • The fear factor is no longer there and a similar thing happened to the West Indies 25 years ago," Lara told News Corp newspapers. (thedailystar.net)
  • Systemic factors stem from the unique health care cultural environment, which is marked by pressures that include increased productivity demands, cost containment requirements, embedded hierarchies, and fear of or stress from litigation. (cdc.gov)
  • This section explains the other factors health assessors need to consider during the EPC and exposure calculation process before excluding a contaminant from further evaluation. (cdc.gov)
  • 23 Further, a variety of factors that mold behavior and values have the potential to influence cultural values and beliefs toward health care ( TABLE 1 ). (uspharmacist.com)
  • Data on health risk factors and conditions were collected in National Health Interview Surveys from household interviews with samples of the civilian, noninstitutionalized population. (cdc.gov)
  • Our health, including our mental well-being, is the result of a multitude of factors, including the complex interactions between our unique genes and the environment. (purepharmacy.com)
  • A variety of dietary factors influence our mental health over our lifespan. (purepharmacy.com)
  • Natural Factors SeaRich Omega-3 - Lemon Meringue - A delicious omega-3 oil made using the freshest, highest quality fish oil, to support cognitive and cardiovascular health. (canadianvitaminshop.com)
  • Therefore, the present study was performed to determine the prevalence of substance use and associated risk factors among high school students in Erbil City, in order to create a database to enable educational and health institutions to take the necessary measures to combat this phenomenon. (who.int)
  • To assess the prevalence and severity of dental fluorosis and its associated factors in teenagers attending schools with oral health programs. (bvsalud.org)
  • Questions cover behavioral risk factors (e.g., alcohol and tobacco use), preventive health measures, health status, limitation of activity, and health care access and utilization. (cdc.gov)
  • This entry was posted in Equity , Social determinants , Universal health coverage and tagged Argentina , Demographic , Medicine National Politics , Socioeconomic factors by Editor Equity/Equidad - DB . (bvsalud.org)
  • Knowing risk factors and resilience factors can help reduce risk, according to the National Institute of Mental Health. (medlineplus.gov)
  • Alcohol consumption has long been recognized as one of the main driving factors of mortality in the Russian Federation, especially among men of working age. (who.int)
  • The Employment Cost Index (ECI) seasonal factors for 2007, along with revised seasonally adjusted indexes and 3-month percent changes for March 2002 thru December 2006 were posted Wednesday, April 25th, 2007 at www.bls.gov/ncs/ect/ectsfact.htm . (bls.gov)
  • This study aimed to determine the prevalence of substance use and certain associated factors among high school students in Erbil City, Kurdistan Region, Iraq. (who.int)
  • Van den Berg SA, Verwer PE, Idema RN, Van Guldener C. Transient cefuroxime/metronidazole treatment induced factor V antibodies. (medscape.com)
  • Varese, Italy - A new meta-analysis has found that cardiovascular risk factors such as obesity , hypertension , and diabetes are associated with venous thromboembolism (VTE) [ 1 ] . (medscape.com)
  • We did confirm an association between some cardiovascular risk factors and VTE," Ageno told heart wire . (medscape.com)
  • But the interesting thing is that these cardiovascular risk factors are much more common in the general population, and they often coexist. (medscape.com)
  • Ageno says there have been studies that have given support to the biological plausibility of an association between some cardiovascular risk factors and VTE, "but what we need to show now is that the treatment of these risk factors is able to prevent VTE. (medscape.com)
  • Fast Five Quiz: How Much Do You Know About Cardiovascular Risk Factors? (medscape.com)
  • Factor scoring of these dimensions indicated that they were associated significantly with relationship satisfaction, duration of longest relationship, extent of attraction to men and women, proportion of social time with gay people, membership of gay/bisexual groups, HIV serostatus, and disclosure of sexual orientation. (researchgate.net)
  • Factors significantly associated with waterpipe smoking were male gender, age 17-19 years, waterpipe smoker in the family, waterpipe smoker friend, and easy accessibility. (who.int)
  • The repository of legislation on risk factors offers Member States organized, systematized, and updated legal information on the main risk factors for noncommunicable diseases (NCDs). (bvsalud.org)
  • Nutritional factors : modulating effects on metabolic processes / editors, Roland F. Beers, Edward G. Bassett. (who.int)
  • The factor function computes the factorization of a multivariate polynomial with integer, rational, (complex) numeric, or algebraic number coefficients. (maplesoft.com)
  • Possible risk factors were determined using univariate and multivariate analysis with logistic regression models. (bvsalud.org)
  • https://rarediseases.info.nih.gov/diseases/6403/factor-v-leiden-thrombophilia. (mayoclinic.org)
  • Your risk of lymphopenia is higher if you have one of the diseases, conditions, or factors that can cause a low lymphocyte count. (nih.gov)
  • When examining chronic diseases and their potential connection to the environment, it is important to consider lifestyle risk factors that could play a role in their development. (cdc.gov)
  • But in nearly 20% of AMA discharges, the researchers identified factors linked to treatment. (medscape.com)
  • The initial treatment of early and moderate bleeds should aim for a peak factor IX (FIX) level of 50 to 60 IU dL −1 . (medscape.com)
  • Risk Factors for Treatment Failure in Skin and Soft Tissue Infections Caused by Nontuberculous Mycobacteria. (bvsalud.org)
  • Delayed treatment for more than 2 months and antibiotic -alone treatment were 2 independent risk factors for treatment failure of NTM SSTIs. (bvsalud.org)
  • To remove a factor level, click the value, click Delete , and click outside the text box. (jmp.com)
  • Select one of those statistics in the Screening and Risk Factors drop-down, and then you can choose County-Level Modeled Estimates in the Data Type drop-down when you choose Counties for a specific state (e.g. (cancer.gov)
  • The key concept you are missing is that of the 12 new factors you expect to find doing the next TF level, P-1 factoring would likely have found 4 of those. (mersenneforum.org)
  • Could Factors Help Explain Asset-Level Real Estate Performance? (msci.com)
  • 1 Testing five potential real estate style factors, we were able to explain an additional 9% of asset-level variation, suggesting that real estate factors could play a role in helping investors manage their portfolios more systematically. (msci.com)
  • To test the potential feasibility of asset-level style factors for real estate, we borrowed cross-sectional regression techniques employed in equities and constructed the five factors in the table below. (msci.com)
  • For joint-immobilizing bleeds, higher initial doses are recommended, which aim to raise the peak factor IX level to 60 to 80 IU dL −1 . (medscape.com)
  • Limiting factors are environmental influences that constrain the productivity of organisms, populations, or communities and thereby prevent them from achieving their full biological potential, which could be realized under optimal conditions. (encyclopedia.com)
  • It is found that the pressure in the chamber is the main factor that influences the cooling ability of the examined media. (astm.org)
  • This is a meeting of the ACRS Subcommittee on Human Factors. (nrc.gov)
  • At Human factors, we study how people overcome limitations and how work can better suit their abilities. (tno.nl)
  • This course provides an understanding of major areas of human factors such as these physical and psychological capabilities and limitations, and how applying human factors can optimise performance in a range of situations. (edu.au)
  • 2. Demonstrate knowledge relevant to theories and models of human factors and human performance. (edu.au)
  • 4. Demonstrate competence in analysing human factors relevant for an organisation and individuals and presenting strategies for improving individual and organisational performance. (edu.au)
  • What Human Factors Affect Construction Safety? (bdjinjurylawyers.com)
  • Thus, trials are needed to examine whether appropriate therapy for CV risk factors-such as aspirin and statins-and lifestyle changes will ameliorate the risk of VTE, he says. (medscape.com)
  • Binary logistic regression models were used to identify risk factors for substance use. (who.int)
  • Scientists have found some risk factors that make a person more likely to develop gallbladder cancer. (cancer.org)
  • Factor V Leiden (FAK-tur five LIDE-n) is a mutation of one of the clotting factors in the blood. (mayoclinic.org)
  • Most people with factor V Leiden never develop abnormal clots. (mayoclinic.org)
  • Both men and women can have factor V Leiden. (mayoclinic.org)
  • Women who carry the factor V Leiden mutation may have an increased tendency to develop blood clots during pregnancy or when taking the hormone estrogen. (mayoclinic.org)
  • If you have factor V Leiden and have developed blood clots, anticoagulant medications can lessen your risk of developing additional blood clots and help you avoid potentially serious complications. (mayoclinic.org)
  • Since factor V Leiden is a risk for developing blood clots in the leg or lungs, the first indication that you have the disorder may be the development of an abnormal blood clot. (mayoclinic.org)
  • If you have factor V Leiden, you inherited either one copy or, rarely, two copies of the defective gene. (mayoclinic.org)
  • A family history of factor V Leiden increases your risk of inheriting the disorder. (mayoclinic.org)
  • People who have inherited factor V Leiden from only one parent have a 5 percent chance of developing an abnormal blood clot by age 65. (mayoclinic.org)
  • Factor V Leiden and activated protein C resistance. (mayoclinic.org)
  • Factor V Leiden and Ischemic Stroke Risk: The Genetics of Early Onset Stroke (GEOS) Study. (medscape.com)
  • Additional risk factors include living in a nursing home, undergoing recent surgery, or requiring the sustained use of a ventilator. (news-medical.net)
  • Environmental and lifestyle factors that promote wrinkling include smoking , degree of pigmentation, heredity (some families wrinkle more), and most important, occupational and recreational sun exposure over many years. (medicinenet.com)
  • Differences in risk factors between the two esophageal cancer subtypes include race, with adenocarcinoma being more prevalent in white males and squamous cell carcinoma being more prevalent in black individuals. (curetoday.com)
  • Other adhesive factors include its pili and fimbriae.Its production of urease and hemolysins are additional pathogenic properties. (medscape.com)
  • To identify factors associated with the development of Pulmonary embolism , a multivariable Binary Logistic Regression model with sensitivity analysis was run. (bvsalud.org)
  • Some diabetes risk factors can be controlled by the lifestyle choices you make. (heart.org)
  • Some factors that increase the risk of diabetes are inherited from our parents or close biological relatives. (heart.org)
  • The anticoagulant function of coagulation factor V. Thromb Haemost . (medscape.com)
  • These risk factors are situations or problems that can increase the possibility that a person will attempt suicide. (cdc.gov)
  • A number of assessment tools are readily available to identify adults' fall risk factors. (mnfallsprevention.org)
  • What are some of the success factors these programs identify? (bai.org)
  • Minerals have an important role as co-factors in metabolic pathways including those involved with neurotransmitter production. (purepharmacy.com)
  • When you have completed your Factors panel, select Save Factors from the red triangle menu. (jmp.com)
  • Gallstones and gallbladder inflammation are important risk factors for gallbladder cancer and are also much more common in women than men. (cancer.org)
  • Create common factors like this template called Common Factors 47 in minutes with SmartDraw. (smartdraw.com)
  • SmartDraw includes common factors templates you can customize and insert into Office. (smartdraw.com)
  • This handout helps outline the most common risk factors associated with HIV/AIDS, as well as best practices for risk reduction. (nnedv.org)
  • What are the common factors of the given numbers? (ezschool.com)
  • What is the greatest common factor of the given numbers? (ezschool.com)
  • 3. Demonstrate knowledge of the factors that can impact upon the behaviour of the individuals in the workplace and how these can be used to structure a work environment that enhances both organisational and individual outcomes. (edu.au)
  • Why is this factor so important? (smallbiztrends.com)
  • Seasonality can be an important factor for commodities investors and that could particularly true this year for oil. (foxbusiness.com)
  • RÉSUMÉ Avec l'allongement de l'espérance de vie, la ménopause est un aspect de la santé de la femme de plus en plus important. (who.int)