Hydrocarbon rings which contain two ketone moieties in any position. They can be substituted in any position except at the ketone groups.
A flavoprotein that reversibly catalyzes the oxidation of NADH or NADPH by various quinones and oxidation-reduction dyes. The enzyme is inhibited by dicoumarol, capsaicin, and caffeine.
NAD(P)H:(quinone acceptor) oxidoreductases. A family that includes three enzymes which are distinguished by their sensitivity to various inhibitors. EC (NAD(P)H DEHYDROGENASE (QUINONE);) is a flavoprotein which reduces various quinones in the presence of NADH or NADPH and is inhibited by dicoumarol. EC (NADH dehydrogenase (quinone)) requires NADH, is inhibited by AMP and 2,4-dinitrophenol but not by dicoumarol or folic acid derivatives. EC (NADPH dehydrogenase (quinone)) requires NADPH and is inhibited by dicoumarol and folic acid derivatives but not by 2,4-dinitrophenol.
A pyrrolo-quinoline having two adjacent keto-groups at the 4 and 5 positions and three acidic carboxyl groups. It is a coenzyme of some DEHYDROGENASES.
Benzene rings which contain two ketone moieties in any position. They can be substituted in any position except at the ketone groups.
An oral anticoagulant that interferes with the metabolism of vitamin K. It is also used in biochemical experiments as an inhibitor of reductases.
INDOLES which have two keto groups forming QUINONES like structures of the indole aromatic ring.
Naphthalene rings which contain two ketone moieties in any position. They can be substituted in any position except at the ketone groups.
A lipid-soluble benzoquinone which is involved in ELECTRON TRANSPORT in mitochondrial preparations. The compound occurs in the majority of aerobic organisms, from bacteria to higher plants and animals.
A chemical reaction in which an electron is transferred from one molecule to another. The electron-donating molecule is the reducing agent or reductant; the electron-accepting molecule is the oxidizing agent or oxidant. Reducing and oxidizing agents function as conjugate reductant-oxidant pairs or redox pairs (Lehninger, Principles of Biochemistry, 1982, p471).
Constituent of 30S subunit prokaryotic ribosomes containing 1600 nucleotides and 21 proteins. 16S rRNA is involved in initiation of polypeptide synthesis.
The relative amounts of the PURINES and PYRIMIDINES in a nucleic acid.
DNA sequences encoding RIBOSOMAL RNA and the segments of DNA separating the individual ribosomal RNA genes, referred to as RIBOSOMAL SPACER DNA.
The process by which ELECTRONS are transported from a reduced substrate to molecular OXYGEN. (From Bennington, Saunders Dictionary and Encyclopedia of Laboratory Medicine and Technology, 1984, p270)
Saturated azacyclopropane compounds. They include compounds with substitutions on CARBON or NITROGEN atoms.
The relationships of groups of organisms as reflected by their genetic makeup.
Organic, monobasic acids derived from hydrocarbons by the equivalent of oxidation of a methyl group to an alcohol, aldehyde, and then acid. Fatty acids are saturated and unsaturated (FATTY ACIDS, UNSATURATED). (Grant & Hackh's Chemical Dictionary, 5th ed)
A lipid cofactor that is required for normal blood clotting. Several forms of vitamin K have been identified: VITAMIN K 1 (phytomenadione) derived from plants, VITAMIN K 2 (menaquinone) from bacteria, and synthetic naphthoquinone provitamins, VITAMIN K 3 (menadione). Vitamin K 3 provitamins, after being alkylated in vivo, exhibit the antifibrinolytic activity of vitamin K. Green leafy vegetables, liver, cheese, butter, and egg yolk are good sources of vitamin K.
Procedures for identifying types and strains of bacteria. The most frequently employed typing systems are BACTERIOPHAGE TYPING and SEROTYPING as well as bacteriocin typing and biotyping.
Deoxyribonucleic acid that makes up the genetic material of bacteria.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Genes, found in both prokaryotes and eukaryotes, which are transcribed to produce the RNA which is incorporated into RIBOSOMES. Prokaryotic rRNA genes are usually found in OPERONS dispersed throughout the GENOME, whereas eukaryotic rRNA genes are clustered, multicistronic transcriptional units.
Polyunsaturated side-chain quinone derivative which is an important link in the electron transport chain of green plants during the photosynthetic conversion of light energy by photophosphorylation into the potential energy of chemical bonds.
Protein complexes that take part in the process of PHOTOSYNTHESIS. They are located within the THYLAKOID MEMBRANES of plant CHLOROPLASTS and a variety of structures in more primitive organisms. There are two major complexes involved in the photosynthetic process called PHOTOSYSTEM I and PHOTOSYSTEM II.
A flavoprotein oxidase complex that contains iron-sulfur centers. It catalyzes the oxidation of SUCCINATE to fumarate and couples the reaction to the reduction of UBIQUINONE to ubiquinol.
The 8-hydroxy derivatives inhibit various enzymes and their halogenated derivatives, though neurotoxic, are used as topical anti-infective agents, among other uses.
Spherical phototrophic bacteria found in mud and stagnant water exposed to light.
A group of substances similar to VITAMIN K 1 which contains a ring of 2-methyl-1,4-naphthoquinione and an isoprenoid side chain of varying number of isoprene units. In vitamin K 2, each isoprene unit contains a double bond. They are produced by bacteria including the normal intestinal flora.
D-Glucose:1-oxidoreductases. Catalyzes the oxidation of D-glucose to D-glucono-gamma-lactone and reduced acceptor. Any acceptor except molecular oxygen is permitted. Includes EC; EC; EC and EC
Small molecules that are required for the catalytic function of ENZYMES. Many VITAMINS are coenzymes.
A beta-hydroxylated derivative of phenylalanine. The D-form of dihydroxyphenylalanine has less physiologic activity than the L-form and is commonly used experimentally to determine whether the pharmacological effects of LEVODOPA are stereospecific.
The class of all enzymes catalyzing oxidoreduction reactions. The substrate that is oxidized is regarded as a hydrogen donor. The systematic name is based on donor:acceptor oxidoreductase. The recommended name will be dehydrogenase, wherever this is possible; as an alternative, reductase can be used. Oxidase is only used in cases where O2 is the acceptor. (Enzyme Nomenclature, 1992, p9)
A group of enzymes including those oxidizing primary monoamines, diamines, and histamine. They are copper proteins, and, as their action depends on a carbonyl group, they are sensitive to inhibition by semicarbazide.
2- or 4-Hydroxyestrogens. Substances that are physiologically active in mammals, especially in the control of gonadotropin secretion. Physiological activity can be ascribed to either an estrogenic action or interaction with the catecholaminergic system.
A multistage process that includes cloning, physical mapping, subcloning, determination of the DNA SEQUENCE, and information analysis.
The presence of bacteria, viruses, and fungi in the soil. This term is not restricted to pathogenic organisms.
A synthetic naphthoquinone without the isoprenoid side chain and biological activity, but can be converted to active vitamin K2, menaquinone, after alkylation in vivo.
Life or metabolic reactions occurring in an environment containing oxygen.
A technique applicable to the wide variety of substances which exhibit paramagnetism because of the magnetic moments of unpaired electrons. The spectra are useful for detection and identification, for determination of electron structure, for study of interactions between molecules, and for measurement of nuclear spins and moments. (From McGraw-Hill Encyclopedia of Science and Technology, 7th edition) Electron nuclear double resonance (ENDOR) spectroscopy is a variant of the technique which can give enhanced resolution. Electron spin resonance analysis can now be used in vivo, including imaging applications such as MAGNETIC RESONANCE IMAGING.
A quinone fungicide used for treatment of seeds and foliage.
A multisubunit enzyme complex that contains CYTOCHROME B GROUP; CYTOCHROME C1; and iron-sulfur centers. It catalyzes the oxidation of ubiquinol to UBIQUINONE, and transfers the electrons to CYTOCHROME C. In MITOCHONDRIA the redox reaction is coupled to the transport of PROTONS across the inner mitochondrial membrane.
Stable elementary particles having the smallest known negative charge, present in all elements; also called negatrons. Positively charged electrons are called positrons. The numbers, energies and arrangement of electrons around atomic nuclei determine the chemical identities of elements. Beams of electrons are called CATHODE RAYS.
At low concentrations, this compound inhibits reduction of conventional hydrophilic electron acceptors, probably acting as a plastoquinone antagonist. At higher concentrations, it acts as an electron acceptor, intercepting electrons either before or at the site of its inhibitory activity.
The location of the atoms, groups or ions relative to one another in a molecule, as well as the number, type and location of covalent bonds.
The rate dynamics in chemical or physical systems.
A mass of organic or inorganic solid fragmented material, or the solid fragment itself, that comes from the weathering of rock and is carried by, suspended in, or dropped by air, water, or ice. It refers also to a mass that is accumulated by any other natural agent and that forms in layers on the earth's surface, such as sand, gravel, silt, mud, fill, or loess. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed, p1689)
A group of 1,2-benzenediols that contain the general formula R-C6H5O2.
A flavoprotein containing oxidoreductase that catalyzes the dehydrogenation of SUCCINATE to fumarate. In most eukaryotic organisms this enzyme is a component of mitochondrial electron transport complex II.
A group of derivatives of naphthyridine carboxylic acid, quinoline carboxylic acid, or NALIDIXIC ACID.
A flavoprotein and iron sulfur-containing oxidoreductase complex that catalyzes the conversion of UBIQUINONE to ubiquinol. In MITOCHONDRIA the complex also couples its reaction to the transport of PROTONS across the internal mitochondrial membrane. The NADH DEHYDROGENASE component of the complex can be isolated and is listed as EC
A family of phylloquinones that contains a ring of 2-methyl-1,4-naphthoquinone and an isoprenoid side chain. Members of this group of vitamin K 1 have only one double bond on the proximal isoprene unit. Rich sources of vitamin K 1 include green plants, algae, and photosynthetic bacteria. Vitamin K1 has antihemorrhagic and prothrombogenic activity.
A basic-leucine zipper transcription factor that was originally described as a transcriptional regulator controlling expression of the BETA-GLOBIN gene. It may regulate the expression of a wide variety of genes that play a role in protecting cells from oxidative damage.
Pigment obtained by the oxidation of epinephrine.
A coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. It is found widely in nature and is involved in numerous enzymatic reactions in which it serves as an electron carrier by being alternately oxidized (NAD+) and reduced (NADH). (Dorland, 27th ed)
Any normal or abnormal coloring matter in PLANTS; ANIMALS or micro-organisms.
A group of oxidoreductases that act on NADH or NADPH. In general, enzymes using NADH or NADPH to reduce a substrate are classified according to the reverse reaction, in which NAD+ or NADP+ is formally regarded as an acceptor. This subclass includes only those enzymes in which some other redox carrier is the acceptor. (Enzyme Nomenclature, 1992, p100) EC 1.6.
Complex cytotoxic antibiotic obtained from Streptomyces flocculus or S. rufochronmogenus. It is used in advanced carcinoma and causes leukopenia.
Mixture of 2- and 3-tert-butyl-4-methoxyphenols that is used as an antioxidant in foods, cosmetics, and pharmaceuticals.
A genus of gram-negative, anaerobic, rod-shaped bacteria isolated from the bovine RUMEN, the human gingival sulcus, and dental PULPITIS infections.
A phylum of bacteria comprised of three classes: Bacteroides, Flavobacteria, and Sphingobacteria.
A family of bacteria which produce endospores. They are mostly saprophytes from soil, but a few are insect or animal parasites or pathogens.
An enzyme of the oxidoreductase class that catalyzes the reaction between L-tyrosine, L-dopa, and oxygen to yield L-dopa, dopaquinone, and water. It is a copper protein that acts also on catechols, catalyzing some of the same reactions as CATECHOL OXIDASE. EC
Nicotinamide adenine dinucleotide phosphate. A coenzyme composed of ribosylnicotinamide 5'-phosphate (NMN) coupled by pyrophosphate linkage to the 5'-phosphate adenosine 2',5'-bisphosphate. It serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH). (Dorland, 27th ed)
A class in the phylum PROTEOBACTERIA comprised mostly of two major phenotypes: purple non-sulfur bacteria and aerobic bacteriochlorophyll-containing bacteria.
A family of bracket fungi, order POLYPORALES, living in decaying plant matter and timber.
The salinated water of OCEANS AND SEAS that provides habitat for marine organisms.
A flavoprotein that reversibly oxidizes NADPH to NADP and a reduced acceptor. EC
Compounds based on ANTHRACENES which contain two KETONES in any position. Substitutions can be in any position except on the ketone groups.
A group of crystallins that have been found in the lens (LENS, CRYSTALLINE) of certain species of VERTEBRATES including GUINEA PIGS; CAMELS; and LLAMAS. They are inactivated forms of NAD(P)H DEHYDROGENASE (QUINONE).
A group of compounds that are derivatives of methoxybenzene and contain the general formula R-C7H7O.
The products of chemical reactions that result in the addition of extraneous chemical groups to DNA.
A coenzyme for a number of oxidative enzymes including NADH DEHYDROGENASE. It is the principal form in which RIBOFLAVIN is found in cells and tissues.
An enzyme of the oxidoreductase class that catalyzes the reaction between catechol and oxygen to yield benzoquinone and water. It is a complex of copper-containing proteins that acts also on a variety of substituted catechols. EC
Enzymes catalyzing the dehydrogenation of secondary amines, introducing a C=N double bond as the primary reaction. In some cases this is later hydrolyzed.
The chemical alteration of an exogenous substance by or in a biological system. The alteration may inactivate the compound or it may result in the production of an active metabolite of an inactive parent compound. The alterations may be divided into METABOLIC DETOXICATION, PHASE I and METABOLIC DETOXICATION, PHASE II.
Reduction of pharmacologic activity or toxicity of a drug or other foreign substance by a living system, usually by enzymatic action. It includes those metabolic transformations that make the substance more soluble for faster renal excretion.
The normality of a solution with respect to HYDROGEN ions; H+. It is related to acidity measurements in most cases by pH = log 1/2[1/(H+)], where (H+) is the hydrogen ion concentration in gram equivalents per liter of solution. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)
A ubiquitous sodium salt that is commonly used to season food.
An estrogenic steroid produced by HORSES. It has a total of five double bonds in the A- and B-ring. High concentration of equilenin is found in the URINE of pregnant mares.
A family of bacteria in the order Sphingobacteriales, class Sphingobacteria. They are gram-negative rods, mostly saprophytic in terrestrial and aquatic habitats.
A genus of gram-negative bacteria widely distributed in fresh water as well as marine and hypersaline habitats.
Ribonucleic acid in bacteria having regulatory and catalytic roles as well as involvement in protein synthesis.
A class of chemicals that contain an anthracene ring with a naphthalene ring attached to it.
Theoretical representations that simulate the behavior or activity of chemical processes or phenomena; includes the use of mathematical equations, computers, and other electronic equipment.
The parts of a macromolecule that directly participate in its specific combination with another molecule.
Widely used technique which exploits the ability of complementary sequences in single-stranded DNAs or RNAs to pair with each other to form a double helix. Hybridization can take place between two complimentary DNA sequences, between a single-stranded DNA and a complementary RNA, or between two RNA sequences. The technique is used to detect and isolate specific sequences, measure homology, or define other characteristics of one or both strands. (Kendrew, Encyclopedia of Molecular Biology, 1994, p503)
A condensation product of riboflavin and adenosine diphosphate. The coenzyme of various aerobic dehydrogenases, e.g., D-amino acid oxidase and L-amino acid oxidase. (Lehninger, Principles of Biochemistry, 1982, p972)
Determination of the spectra of ultraviolet absorption by specific molecules in gases or liquids, for example Cl2, SO2, NO2, CS2, ozone, mercury vapor, and various unsaturated compounds. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
A flavoprotein and iron sulfur-containing oxidoreductase that catalyzes the oxidation of NADH to NAD. In eukaryotes the enzyme can be found as a component of mitochondrial electron transport complex I. Under experimental conditions the enzyme can use CYTOCHROME C GROUP as the reducing cofactor. The enzyme was formerly listed as EC
Former kingdom, located on Korea Peninsula between Sea of Japan and Yellow Sea on east coast of Asia. In 1948, the kingdom ceased and two independent countries were formed, divided by the 38th parallel.
Proteins found in any species of bacterium.
The art or process of comparing photometrically the relative intensities of the light in different parts of the spectrum.
An order of gram-positive, primarily aerobic BACTERIA that tend to form branching filaments.
A naturally occurring phenolic acid which is a carcinogenic inhibitor. It has also been shown to prevent paraquat-induced oxidative stress in rats. (From J Chromatogr A 1996;741(2):223-31; Biosci Biotechnol Biochem 1996;60(5):765-68).
A subclass of enzymes which includes all dehydrogenases acting on primary and secondary alcohols as well as hemiacetals. They are further classified according to the acceptor which can be NAD+ or NADP+ (subclass 1.1.1), cytochrome (1.1.2), oxygen (1.1.3), quinone (1.1.5), or another acceptor (1.1.99).
Liquid chromatographic techniques which feature high inlet pressures, high sensitivity, and high speed.
A potent mutagen and carcinogen. It is a public health concern because of its possible effects on industrial workers, as an environmental pollutant, an as a component of tobacco smoke.
The restriction of a characteristic behavior, anatomical structure or physical system, such as immune response; metabolic response, or gene or gene variant to the members of one species. It refers to that property which differentiates one species from another but it is also used for phylogenetic levels higher or lower than the species.
Naturally occurring or synthetic substances that inhibit or retard the oxidation of a substance to which it is added. They counteract the harmful and damaging effects of oxidation in animal tissues.
A transferase that catalyzes the addition of aliphatic, aromatic, or heterocyclic FREE RADICALS as well as EPOXIDES and arene oxides to GLUTATHIONE. Addition takes place at the SULFUR. It also catalyzes the reduction of polyol nitrate by glutathione to polyol and nitrite.
A tripeptide with many roles in cells. It conjugates to drugs to make them more soluble for excretion, is a cofactor for some enzymes, is involved in protein disulfide bond rearrangement and reduces peroxides.
Models used experimentally or theoretically to study molecular shape, electronic properties, or interactions; includes analogous molecules, computer-generated graphics, and mechanical structures.
The measurement of the amplitude of the components of a complex waveform throughout the frequency range of the waveform. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)
An increase in the rate of synthesis of an enzyme due to the presence of an inducer which acts to derepress the gene responsible for enzyme synthesis.
Stable elementary particles having the smallest known positive charge, found in the nuclei of all elements. The proton mass is less than that of a neutron. A proton is the nucleus of the light hydrogen atom, i.e., the hydrogen ion.
A species of gram-negative, facultatively anaerobic, rod-shaped bacteria (GRAM-NEGATIVE FACULTATIVELY ANAEROBIC RODS) commonly found in the lower part of the intestine of warm-blooded animals. It is usually nonpathogenic, but some strains are known to produce DIARRHEA and pyogenic infections. Pathogenic strains (virotypes) are classified by their specific pathogenic mechanisms such as toxins (ENTEROTOXIGENIC ESCHERICHIA COLI), etc.
A group of the proteobacteria comprised of facultatively anaerobic and fermentative gram-negative bacteria.
The Borage plant family is in the class Magnoliopsida, subclass Asteridae, order Lamiales. It is characterized by hairy foliage, usually alternate and simple; flowers are funnel-shaped or tubular. Some of the species contain PYRROLIZIDINE ALKALOIDS.
Reversibly catalyze the oxidation of a hydroxyl group of carbohydrates to form a keto sugar, aldehyde or lactone. Any acceptor except molecular oxygen is permitted. Includes EC 1.1.1.; EC 1.1.2.; and 1.1.99.
Derivatives of the dimethylisoalloxazine (7,8-dimethylbenzo[g]pteridine-2,4(3H,10H)-dione) skeleton. Flavin derivatives serve an electron transfer function as ENZYME COFACTORS in FLAVOPROTEINS.
A group of proteins possessing only the iron-sulfur complex as the prosthetic group. These proteins participate in all major pathways of electron transport: photosynthesis, respiration, hydroxylation and bacterial hydrogen and nitrogen fixation.
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
Highly reactive molecules with an unsatisfied electron valence pair. Free radicals are produced in both normal and pathological processes. They are proven or suspected agents of tissue damage in a wide variety of circumstances including radiation, damage from environment chemicals, and aging. Natural and pharmacological prevention of free radical damage is being actively investigated.
Pyrrole containing pigments found in photosynthetic bacteria.
Cytochromes (electron-transporting proteins) with protoheme (HEME B) as the prosthetic group.
The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment.
Refuse liquid or waste matter carried off by sewers.
A large multisubunit protein complex found in the THYLAKOID MEMBRANE. It uses light energy derived from LIGHT-HARVESTING PROTEIN COMPLEXES to catalyze the splitting of WATER into DIOXYGEN and of reducing equivalents of HYDROGEN.
The complete absence, or (loosely) the paucity, of gaseous or dissolved elemental oxygen in a given place or environment. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)
Organic compounds with the general formula R-NCS.
A family of gram-negative bacteria, in the order Xanthomonadales, pathogenic to plants.
Porphyrin derivatives containing magnesium that act to convert light energy in photosynthetic organisms.
Non-pathogenic ovoid to rod-shaped bacteria that are widely distributed and found in fresh water as well as marine and hypersaline habitats.
The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide using energy obtained from light rather than from the oxidation of chemical compounds. Photosynthesis comprises two separate processes: the light reactions and the dark reactions. In higher plants; GREEN ALGAE; and CYANOBACTERIA; NADPH and ATP formed by the light reactions drive the dark reactions which result in the fixation of carbon dioxide. (from Oxford Dictionary of Biochemistry and Molecular Biology, 2001)
An experimental lymphocytic leukemia of mice.
Complexes containing CHLOROPHYLL and other photosensitive molecules. They serve to capture energy in the form of PHOTONS and are generally found as components of the PHOTOSYSTEM I PROTEIN COMPLEX or the PHOTOSYSTEM II PROTEIN COMPLEX.
A flavoprotein containing oxidoreductase that catalyzes the reduction of lipoamide by NADH to yield dihydrolipoamide and NAD+. The enzyme is a component of several MULTIENZYME COMPLEXES.
The property of objects that determines the direction of heat flow when they are placed in direct thermal contact. The temperature is the energy of microscopic motions (vibrational and translational) of the particles of atoms.
A protein complex that includes CYTOCHROME B6 and CYTOCHROME F. It is found in the THYLAKOID MEMBRANE and plays an important role in process of PHOTOSYNTHESIS by transferring electrons from PLASTOQUINONE to PLASTOCYANIN or CYTOCHROME C6. The transfer of electrons is coupled to the transport of PROTONS across the membrane.
The study of chemical changes resulting from electrical action and electrical activity resulting from chemical changes.
A genus of asporogenous bacteria isolated from soil that displays a distinctive rod-coccus growth cycle.
The presence of bacteria, viruses, and fungi in water. This term is not restricted to pathogenic organisms.
Diazo derivatives of aniline, used as a reagent for sugars, ketones, and aldehydes. (Dorland, 28th ed)
A large multisubunit protein complex that is found in the THYLAKOID MEMBRANE. It uses light energy derived from LIGHT-HARVESTING PROTEIN COMPLEXES to drive electron transfer reactions that result in either the reduction of NADP to NADPH or the transport of PROTONS across the membrane.
The relationship between the chemical structure of a compound and its biological or pharmacological activity. Compounds are often classed together because they have structural characteristics in common including shape, size, stereochemical arrangement, and distribution of functional groups.
An element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on earth and essential for respiration.
Hemeproteins whose characteristic mode of action involves transfer of reducing equivalents which are associated with a reversible change in oxidation state of the prosthetic group. Formally, this redox change involves a single-electron, reversible equilibrium between the Fe(II) and Fe(III) states of the central iron atom (From Enzyme Nomenclature, 1992, p539). The various cytochrome subclasses are organized by the type of HEME and by the wavelength range of their reduced alpha-absorption bands.
Systems of enzymes which function sequentially by catalyzing consecutive reactions linked by common metabolic intermediates. They may involve simply a transfer of water molecules or hydrogen atoms and may be associated with large supramolecular structures such as MITOCHONDRIA or RIBOSOMES.
The study of crystal structure using X-RAY DIFFRACTION techniques. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
An antineoplastic antibiotic produced by Streptomyces caespitosus. It is one of the bi- or tri-functional ALKYLATING AGENTS causing cross-linking of DNA and inhibition of DNA synthesis.
A family of gram-negative, asporogenous rods or ovoid cells, aerobic or facultative anaerobic chemoorganotrophs. They are commonly isolated from SOIL, activated sludge, or marine environments.

Assaying potential carcinogens with Drosophila. (1/2088)

Drosophila offers many advantages for the detection of mutagenic activity of carcinogenic agents. It provides the quickest assay system for detecting mutations in animals today. Its generation time is short, and Drosophila is cheap and easy to breed in large numbers. The simple genetic testing methods give unequivocal answers about the whole spectrum of relevant genetic damage. A comparison of the detection capacity of assays sampling different kinds of genetic damage revealed that various substances are highly effective in inducing mutations but do not produce chromosome breakage effects at all, or only at much higher concentrations than those required for mutation induction. Of the different assay systems available, the classical sex-linked recessive lethal test deserves priority, in view of its superior capacity to detect mutagens. Of practical importance is also its high sensitivity, because a large number of loci in one fifth of the genome is tested for newly induced forward mutations, including small deletions. The recent findings that Drosophila is capable of carrying out the same metabolic activation reactions as the mammalian liver makes the organism eminently suitable for verifying results obtained in prescreening with fast microbial assay systems. An additional advantage in this respect is the capacity of Drosophila for detecting short-lived activation products, because intracellular metabolic activation appears to occur within the spermatids and spermatocytes.  (+info)

p50(cdc37) acting in concert with Hsp90 is required for Raf-1 function. (2/2088)

Genetic screens in Drosophila have identified p50(cdc37) to be an essential component of the sevenless receptor/mitogen-activated kinase protein (MAPK) signaling pathway, but neither the function nor the target of p50(cdc37) in this pathway has been defined. In this study, we examined the role of p50(cdc37) and its Hsp90 chaperone partner in Raf/Mek/MAPK signaling biochemically. We found that coexpression of wild-type p50(cdc37) with Raf-1 resulted in robust and dose-dependent activation of Raf-1 in Sf9 cells. In addition, p50(cdc37) greatly potentiated v-Src-mediated Raf-1 activation. Moreover, we found that p50(cdc37) is the primary determinant of Hsp90 recruitment to Raf-1. Overexpression of a p50(cdc37) mutant which is unable to recruit Hsp90 into the Raf-1 complex inhibited Raf-1 and MAPK activation by growth factors. Similarly, pretreatment with geldanamycin (GA), an Hsp90-specific inhibitor, prevented both the association of Raf-1 with the p50(cdc37)-Hsp90 heterodimer and Raf-1 kinase activation by serum. Activation of Raf-1 via baculovirus coexpression with oncogenic Src or Ras in Sf9 cells was also strongly inhibited by dominant negative p50(cdc37) or by GA. Thus, formation of a ternary Raf-1-p50(cdc37)-Hsp90 complex is crucial for Raf-1 activity and MAPK pathway signaling. These results provide the first biochemical evidence for the requirement of the p50(cdc37)-Hsp90 complex in protein kinase regulation and for Raf-1 function in particular.  (+info)

UV irradiation of polycyclic aromatic hydrocarbons in ices: production of alcohols, quinones, and ethers. (3/2088)

Polycyclic aromatic hydrocarbons (PAHs) in water ice were exposed to ultraviolet (UV) radiation under astrophysical conditions, and the products were analyzed by infrared spectroscopy and mass spectrometry. Peripheral carbon atoms were oxidized, producing aromatic alcohols, ketones, and ethers, and reduced, producing partially hydrogenated aromatic hydrocarbons, molecules that account for the interstellar 3.4-micrometer emission feature. These classes of compounds are all present in carbonaceous meteorites. Hydrogen and deuterium atoms exchange readily between the PAHs and the ice, which may explain the deuterium enrichments found in certain meteoritic molecules. This work has important implications for extraterrestrial organics in biogenesis.  (+info)

Salmonella typhimurium and lipopolysaccharide stimulate extracellularly regulated kinase activation in macrophages by a mechanism involving phosphatidylinositol 3-kinase and phospholipase D as novel intermediates. (4/2088)

Activation of the extracellularly regulated kinase (ERK) pathway is part of the early biochemical events that follow lipopolysaccharide (LPS) treatment of macrophages or their infection by virulent and attenuated Salmonella strains. Phagocytosis as well as the secretion of invasion-associated proteins is dispensable for ERK activation by the pathogen. Furthermore, the pathways used by Salmonella and LPS to stimulate ERK are identical, suggesting that kinase activation might be solely mediated by LPS. Both stimuli activate ERK by a mechanism involving herbimycin-dependent tyrosine kinase(s) and phosphatidylinositol 3-kinase. Phospholipase D activation and stimulation of protein kinase C appear to be intermediates in this novel pathway of MEK/ERK activation.  (+info)

Involvement of tyrosine phosphorylation in HMG-CoA reductase inhibitor-induced cell death in L6 myoblasts. (5/2088)

Our previous studies have shown that the HMG-CoA reductase (HCR) inhibitor (HCRI), simvastatin, causes myopathy in rabbits and kills L6 myoblasts. The present study was designed to elucidate the molecular mechanism of HCRI-induced cell death. We have demonstrated that simvastatin induces the tyrosine phosphorylation of several cellular proteins within 10 min. These phosphorylations were followed by apoptosis, as evidenced by the occurrence of internucleosomal DNA fragmentation and by morphological changes detected with Nomarski optics. Simvastatin-induced cell death was prevented by tyrosine kinase inhibitors. The MTT assay revealed that the addition of mevalonic acid into the culture medium partially inhibited simvastatin-induced cell death. Thus, these results suggested that protein tyrosine phosphorylation might play an important role in the intracellular signal transduction pathway mediating the HCRI-induced death of myoblasts.  (+info)

Dose-specific production of chlorinated quinone and semiquinone adducts in rodent livers following administration of pentachlorophenol. (6/2088)

Production of chlorinated quinoid metabolites was investigated in the livers of Sprague-Dawley rats and B6C3F1 mice following single oral administration of pentachlorophenol (PCP) (0-40 mg/kg body weight) and in male Fischer 344 rats, following chronic ingestion of PCP at 1,000 ppm in the diet for 6 months (equivalent to 60 mg PCP/kg body weight/day). Analyses of the rates of adduction in the livers of Sprague-Dawley rats and B6C3F1 mice suggested that the production of tetrachloro-1,2-benzosemiquinone (Cl4-1,2-SQ) adducts was proportionally greater at low doses of PCP (less than 4-10 mg/kg body weight) and was 40-fold greater in rats than in mice. Production of tetrachloro-1,4-benzoquinone (Cl4-1,4-BQ) adducts, on the other hand, was proportionally greater at high doses of PCP [greater than 60-230 mg/kg body weight] and was 2- to 11-fold greater in mice than in rats over the entire range of dosages. A mathematical model employed these data to predict the rates of daily adduct production and steady state levels of PCP-derived quinone and semiquinone adducts in rats and mice. To evaluate predictions of the model, levels of PCP-derived adducts at steady state were investigated in the livers of male Fischer 344 rats chronically ingesting 60 mg PCP/kg body weight/day. Levels of total Cl4-1,4-BQ-derived adducts in liver cytosolic proteins (Cp) (22.0 nmol/g) and in liver nuclear proteins (Np) (3.07 nmol/g) were comparable to those of model predictions (15.0 and 3.02 nmol/g for Cp and Np, respectively). Overall, these results suggest that species differences in the metabolism of PCP to semiquinones and quinones were, in part, responsible for the production of liver tumors in mice but not rats in chronic bioassays.  (+info)

Stimulation of ultraviolet-induced apoptosis of human fibroblast UVr-1 cells by tyrosine kinase inhibitors. (7/2088)

Damnacanthal is an anthraquinone compound isolated from the root of Morinda citrifolia and was reported to have a potent inhibitory activity towards tyrosine kinases such as Lck, Src, Lyn and EGF receptor. In the present study, we have examined the effects of damnacanthal on ultraviolet ray-induced apoptosis in ultraviolet-resistant human UVr-1 cells. When the cells were treated with damnacanthal prior to ultraviolet irradiation, DNA fragmentation was more pronounced as compared to the case of ultraviolet irradiation alone. The other tyrosine kinase inhibitors, herbimycin A and genistein, also caused similar effects on ultraviolet-induced apoptosis but to a lesser extent. Serine/threonine kinase inhibitors, K252a, staurosporine and GF109203X, rather suppressed the ultraviolet-induced DNA cleavage. Immunoblot analysis showed that pretreatment with damnacanthal followed by ultraviolet irradiation increased the levels of phosphorylated extracellular signal-regulated kinases and stress-activated protein kinases. However, the other tyrosine kinase inhibitors did not increase the phosphorylation of extracellular signal-regulated kinases but stimulated phosphorylation of stress-activated protein kinases. Consequently, the ultraviolet-induced concurrent increase in both phosphorylated extracellular signal-regulated kinases and stress-activated protein kinases after pretreatment with damnacanthal might be characteristically related to the stimulatory effect of damnacanthal on ultraviolet-induced apoptosis.  (+info)

Terreic acid, a quinone epoxide inhibitor of Bruton's tyrosine kinase. (8/2088)

Bruton's tyrosine kinase (Btk) plays pivotal roles in mast cell activation as well as in B cell development. Btk mutations lead to severe impairments in proinflammatory cytokine production induced by cross-linking of high-affinity IgE receptor on mast cells. By using an in vitro assay to measure the activity that blocks the interaction between protein kinase C and the pleckstrin homology domain of Btk, terreic acid (TA) was identified and characterized in this study. This quinone epoxide specifically inhibited the enzymatic activity of Btk in mast cells and cell-free assays. TA faithfully recapitulated the phenotypic defects of btk mutant mast cells in high-affinity IgE receptor-stimulated wild-type mast cells without affecting the enzymatic activities and expressions of many other signaling molecules, including those of protein kinase C. Therefore, this study confirmed the important roles of Btk in mast cell functions and showed the usefulness of TA in probing into the functions of Btk in mast cells and other immune cell systems. Another insight obtained from this study is that the screening method used to identify TA is a useful approach to finding more efficacious Btk inhibitors.  (+info)

ortho-Quinones are produced in vivo through the oxidation of catecholic substrates by enzymes such as tyrosinase or by transition metal ions. Neuromelanin, a dark pigment present in the substantia nigra and locus coeruleus of the brain, is produced from dopamine (DA) and norepinephrine (NE) via an interaction with cysteine, but it also incorporates their alcoholic and acidic metabolites. In this study we examined the metabolic fate of ortho-quinones derived from the catecholamine metabolites, 3,4-dihydroxyphenylethanol (DOPE), 3,4-dihydroxyphenylethylene glycol (DOPEG), 3,4-dihydroxyphenylacetic acid (DOPAC) and 3,4-dihydroxyphenylmandelic acid (DOMA). The oxidation of catecholic substrates by mushroom tyrosinase was followed by UV-visible spectrophotometry. HPLC analysis after reduction with NaBH4 or ascorbic acid enabled measurement of the half-lives of ortho-quinones and the identification of their reaction products. Spectrophotometric examination showed that the ortho-quinones initially formed
The quinones are a class of organic compounds that are formally derived from aromatic compounds [such as benzene or naphthalene] by conversion of an even number of -CH= groups into -C(=O)- groups with any necessary rearrangement of double bonds, resulting in a fully conjugated cyclic dione structure. The class includes some heterocyclic compounds.. The archetypical member of the class is 1,4-benzoquinone or cyclohexadienedione, often called simply quinone (thus the name of the class). Other important examples are 1,2-benzoquinone (ortho-quinone), 1,4-naphthoquinone and 9,10-anthraquinone.. Quinones are oxidized derivatives of aromatic compounds and are often readily made from reactive aromatic compounds with electron-donating substituents such as phenols and catechols, which increase the nucleophilicity of the ring and contributes to the large redox potential needed to break aromaticity. (Quinones are conjugated but not aromatic). Quinones are electrophilic Michael acceptors stabilised by ...
Quinone is also called 1,4-benzoquinone or cyclohexadienedione. Quinones are oxidized derivatives of aromatic compounds and are often readily made from reactive aromatic compounds with electron-donating substituents such as phenols and catechols, which increase the nucleophilicity of the ring and contributes to the large redox potential needed to break aromaticity. Derivatives of quinones are common constituents of biologically relevant molecules. Some serve as electron acceptors in electron transport chains such as those in photosynthesis (plastoquinone, phylloquinone), and aerobic respiration (ubiquinone ...
Quinones represent a class of toxicological intermediates which can create a variety of hazardous effects in vivo, including acute cytotoxicity, immunotoxicity, and carcinogenesis. The mechanisms by which quinones cause these effects can be quite complex. Quinones are Michael acceptors, and cellular …
Latt and Ahsen sit down with anime and video game voice Actress, Anairis Quinones. Join the duo as they meet with Anairis to discuss her major roles as Harriot Bee, Nessa, and My Hero Academias Mirko! They also delve into diversity in voice acting, c
Cagefighter: Worlds Collide (2020) réalisé par Jesse Quinones. Linformation sur le film, genre, classement, durée, photos, bande-annonce, synopsis et critiques des usagers.
Octagons is a Cage Fighting lyrical powerhouse, laid over bass-drop fuelled, punchy US-style beats.. Sponsors by Fight Gritty, Epic Studios, Contenders MMA. Artist: Jab Singh. Director: Jesse Quinones. ...
The mechanisms underlying this programmed elevation afterwards in existence pursuing an adverse in utero atmosphere a1062368-62-0re nevertheless to be decided.
Quinones can be cytotoxic through several mechanisms of action, including redox cycles, arylation of the thiol groups of proteins, intercalation, induction of breaks in the DNA chain, generation of free radicals and other reactive oxygen species (ROS) and bioreductive alkylation via the formation of quinone methide. However, it is still unclear whether one mechanism of action is more prevalent than the others. Synthetic analogs can be modulated to act selectively via one of several mechanisms of action, especially when the structures of the synthesized molecules are similar to the natural or endogenous quinones of the organisms. In these cases, it is reasonable that these analogs can act in the same way and interfere in the same cellular biochemical processes. For example, quinones are involved in the intracellular transport of electrons, and it is generally accepted that exogenous quinones can transfer electrons in biological processes; this is an important cyclic property as oxidation is ...
Physiological quinones carrying isoprenoid side chains have been compared with homologues lacking the side chain, for their ability to carry electrons and protons from dithionite to ferricyanide, trapped in liposomes. Six differential observations were made: (1) Plastoquinone and ubiquinones, with a side chain of more than two isoprene units, are by far better mediators than their short-chain homologues. Also other benzoquinones lacking a long side chain are poor catalysts, except dimethyl-methylenedioxy-p-benzoquinone, a highly autooxidizable compound. Tocopherol is a good catalyst. (2) Vitamin K-1 and K-2 are poor mediators compared to vitamin K-3. (3) The reaction catalyzed by quinones carrying long isoprenoid side chains has an about three-fold higher activation energy, irrespective of the catalytic efficiency. (4) The reaction catalyzed by quinones lacking a long side chain follows pseudo first-order kinetics, while the reaction with quinones carrying a long side chain is of apparently higher order
1. A comparison is made of several procedures for the extraction of tocopherols and isoprenoid quinones from plant tissues. 2. Gradient-elution column chromatography on acid-washed alumina efficiently separates the isoprenoid quinones and tocopherols into groups that can then be assayed spectrophotometrically or, with the tocopherols, separated into their individual components and determined by gas-liquid chromatography. 3. This improved analytical procedure was used to study the distribution of the tocopherols and of ubiquinone in the ungerminated wheat grain.. ...
The quinones represent a class of organic compounds that are formally derived from aromatic compounds [such as benzene or naphthalene] by conversion of an even number of -CH= groups into -C(=O)- groups with any necessary rearrangement of double bonds, resulting in a fully conjugated cyclic dione structure. The class includes some heterocyclic compounds. A large scale industrial application of quinones is for the production of hydrogen peroxide. Natural quinones show a biological or pharmacological activity, and some of them show anti-tumoral activity. They embody some claims in herbal medicine. Some quinone derivatives are used for coloring substances (dyes and pigments) and oxidizing agents.. ...
Quinones Coat of Arms and Quinones Family Crest. Learn about the history of this surname and heraldry from our database and online image library.
All experimentally characterized proteins in this family are 1,4-benzoquinone reductases. These are intracellular enzymes involved in the biodegradation of aromatic compounds and in the protection of fungal cells from reactive quinone compounds ...
Cordiachromes A-F are terpenoid benzoquinones isolated from the heartwood of . Cordiachrome C (3; R = H) has a benzogeijerene and A (1; R = H) and B (2; R = H) have a benzocogeijerene skeleton. Cordiachromes D-F are methoxy-derivatives of A-C, respectively. All six are optically inactive. Biogenetically they appear
Find Latest Custom Import Duty in India of HS code 2914 KETONES QUINONES OXYGEN FUNCTION HALOGENATED. View Indian customs tariff, taxes, Import duty calculator rates Charts.
The bistability in the position of the two hydrogen atoms in the inner cavity of single free-base naphthalocyanine molecules constitutes a two-level system that was manipulated and probed by low-temperature scanning tunneling microscopy. When adsorbed on an ultrathin insulating film, the molecules can be switched in a controlled fashion between the two states by excitation induced by the inelastic tunneling current. The tautomerization reaction can be probed by resonant tunneling through the molecule and is expressed as considerable changes in the conductivity of the molecule. We also demonstrated a coupling of the switching process so that the charge injection in one molecule induced tautomerization in an adjacent molecule.. ...
Quantitative determination of quinone chromophores in isolated lignins. . Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.
Written by: Alan BurnettArt by: Ty TempletonCover Art by: Joe Quinones Deathstroke makes his move against the Dark Knight, but hes not just going to strike at him physically - hes going to try to destroy him completely by using the rest of the Bat-Family against him!
John Quinones is the well-known Emmy award-winning co-anchor of ABCs Primetime and a series of reports entitled What Would You Do?
Gentaur molecular products has all kinds of products like :search , Kamiya \ Herbimycin A \ KT-375 for more molecular products just contact us
Arnie Quinones Community Meeting: Part 12020-02-26T18:30:00. Join us for a series of community park design meetings, and to let us know what features you would like to see included at Arnie Quinones Park, Phase II. Project will be submitted for State and/or County grant funds for construction. The meetings will be held in two parts: Part 1: An overview and discussion of proposed park amenities. Part 2: Presentation of a site plan for resident review and comment.. Gregg Anderson Academy5151 West Avenue N-8PalmdaleCA93551 ...
MDPen is a MicroNeedling device that moves at speeds up to 17,500 RPM creating 15,000 micro channels per square inch for maximum coverage and a more complete treatment. ...
usage: any of several quinones found in living cells and that function as coenzymes that transfer electrons from one molecule to another in cell ...
Click on a genes description to view its network relationships with genes known to be involved in quinone metabolic process ...
Guo W, Reigan P, Siegel D, Ross D. Enzymatic reduction and glutathione conjugation of benzoquinone ansamycin heat shock protein 90 inhibitors: relevance for toxicity and mechanism of action. Drug Metab Dispos. 2008 Oct; 36(10):2050-7 ...
TY - JOUR. T1 - Slow loss of deoxyribose from the N7deoxyguanosine adducts of estradiol-3,4-quinone and hexestrol-3′,4′-quinone.. T2 - Implications for mutagenic activity. AU - Saeed, Muhammad. AU - Zahid, Muhammad. AU - Gunselman, Sandra J.. AU - Rogan, Eleanor. AU - Cavalieri, Ercole. PY - 2005/1. Y1 - 2005/1. N2 - A variety of evidence has been obtained that estrogens are weak tumor initiators. A major step in the multi-stage process leading to tumor initiation involves metabolic formation of 4-catechol estrogens from estradiol (E 2) and/or estrone and further oxidation of the catechol estrogens to the corresponding catechol estrogen quinones. The electrophilic catechol quinones react with DNA mostly at the N-3 of adenine (Ade) and N-7 of guanine (Gua) by 1,4-Michael addition to form depurinating adducts. The N3Ade adducts depurinate instantaneously, whereas the N7Gua adducts depurinate with a half-life of several hours. Only the apurinic sites generated in the DNA by the rapidly ...
The invention relates to benzoquinone ansamycin analogs useful for the treatment of cancer and other diseases or conditions characterized by undesired cellular proliferation or hyperproliferation. Therapies involving the administration of such benzoquinone ansamycin analogs, optionally in combination with an inhibitor of an HSP90 client protein, are useful to treat cancer and non-cancerous disease conditions.
1. HT-29 M6 cells are a subpopulation of HT-29 cells that, contrarily to the parental cells, establish tight cell contacts and differentiate. Cell-to-cell contacts in HT-29 M6 cells are also regulated by protein kinase C; addition of the phorbol ester phorbol 12-myristate 13-acetate (PMA) decreases the homotypic contacts of these cells. We show here that HT-29 cells or HT-29 M6 cells treated with PMA contain lower levels of functional E-cadherin, determined by analysing the association of this protein with the cytoskeleton. No significant differences in the localization of α-, β-, or p120-catenins were detected under the three different conditions. 2. Dysfunction of E-cadherin can be reversed by incubation of HT-29 cells with the tyrosine kinase inhibitor herbimycin A. On the other hand an augmentation of c-src activity in HT-29 cells or HT-29 M6 cells treated with PMA was observed with respect to control HT-29 M6 cells. The phosphorylation status of catenins was also investigated; in HT-29 or ...
TY - JOUR. T1 - NAD(P)H:quinone oxidoreductase 1 Arg139Trp and Pro187Ser polymorphisms imbalance estrogen metabolism towards DNA adduct formation in human mammary epithelial cells. AU - Singh, Seema. AU - Zahid, Muhammad. AU - Saeed, Muhammad. AU - Gaikwad, Nilesh W.. AU - Meza, Jane L.. AU - Cavalieri, Ercole L.. AU - Rogan, Eleanor G.. AU - Chakravarti, Dhrubajyoti. PY - 2009/10. Y1 - 2009/10. N2 - Estrogens (estrone, E1; estradiol, E2) are oxidized in the breast first to catechols and then to form two ortho-quinones (E1/2-3,4-Q) that react with DNA to form depurinating adducts, which lead to mutations associated with breast cancer. NAD(P)H:quinone oxidoreductase 1 (NQO1) reduces these quinones back to catechols, and thus may protect against this mechanism. We examined whether the inheritance of two polymorphic variants of NQO1 (Pro187Ser or Arg139Trp) would result in poor reduction of E1/2-3,4-Q in normal human mammary epithelial cells (MCF-10F) and increased depurinating adduct formation. An ...
Although boric acid is known to complex with various polyalcohols, it is often used as a component of buffer mixtures. Electrochemical and spectrophotometric experiments have shown that borate buffers exhibit two types of interference with ortho quinone redox systems. Ortho quinones themselves exist in equilibrium with electroinactive complexes in borate solutions. The corresponding hydroquinones formed by reduction of the quinones complex even more strongly giving complexes which may be oxidized back to the quinone, but at a much higher potential than for the hydroquinone.. ...
Herbimycin A, 1 mg. Herbimycin A, a benzoquinoid ansamycin antibiotic, irreversibly and selectively inhibits tyrosine kinases by reacting with thiol groups (1,2).
Interpretive Summary: [This article is a review of the past 30 years of research by our group (and others) on quinone methides, important intermediates associated with lignin.] Lignins are large complex molecules that are prominent in plant cell walls, perhaps accounting for as much as 20% of terrestrial biomass. They hold together the fibers, and are involved in plant defense and water transport throughout the plant. Lignins are made from coupling reactions of the small-molecule lignin building blocks, with each other or, more importantly, with the growing, large complex molecule. Each coupling reaction produces an intermediate structure, a quinone methide, that then reacts in various ways to produce the final structure in lignin. Therefore, quinone methide reactivity and structure are key factors in the important process of lignification. Lignification, and the reactions of the intermediary quinone methides in particular, are increasingly seen as crucial to understanding the key role of lignin ...
TPH is presently shown to be inactivated after exposure to DA under specified conditions. All aspects of the data support the conclusion that DA-derived quinones are the agents mediating the inactivation. First, preincubation with DA alone had no effect on TPH activity. Second, conditions that prompt the conversion of DA to one of its quinones lead to significant reductions in TPH catalytic function. Because DA can be the source of numerous, different quinones (Graham, 1978; Graham et al., 1978; Kelgaris et al., 1995), we tested three representative ones in an attempt to establish the generality of their effects on TPH. DA was oxidized by iron + H2O2to semiquinones and quinones as described in Equations 1-3. DA was also converted enzymatically to the aminochrome by tyrosinase, and finally, N-acetyl-DA was oxidized by NaIO4 to the more stable o-quinone (Graham, 1978; Graham et al., 1978). Each quinone caused significant inactivations of TPH. Third, GSH, DTT, and ascorbic acid protected TPH from ...
The cytotoxic and antiproliferative properties of many natural sesquiterpene-quinones and -hydroquinones from sponges offer promising opportunities for the development of new drugs. A review dealing with different strategies for obtaining bioactive terpenyl quinones/hydroquinones is presented. The different synthetic approches for the preparation of the most relevant quinones/hydroquinones are described.
Competing models of mitochondrial energy metabolism in the heart are highly disputed. In addition, the mechanisms of reactive oxygen species (ROS) production and scavenging are not well understood. To deepen our understanding of these processes, a computer model was developed to integrate the biophysical processes of oxidative phosphorylation and ROS generation. The model was calibrated with experimental data obtained from isolated rat heart mitochondria subjected to physiological conditions and workloads. Model simulations show that changes in the quinone pool redox state are responsible for the apparent inorganic phosphate activation of complex III. Model simulations predict that complex III is responsible for more ROS production during physiological working conditions relative to complex I. However, this relationship is reversed under pathological conditions. Finally, model analysis reveals how a highly reduced quinone pool caused by elevated levels of succinate is likely responsible for the ...
Ilyas Washington from Columbia University Medical Center will be delivering a seminar on How Inhibiting The Dimerization Of Vitamin A and/or Catalyzing The Reduction of Quinones May Prevent Retinal Degeneration on Wednesday, February 11th, 2015 in the Moran Eye Center auditorium. Abstract: Many human conditions, originating from multiple genetic and environmental pressures, converge to overproduce superoxide radical anions. The […]. ...
Dr. Ruckers research focus is on the role of nutrients in early growth and development and the physiological roles of quinone cofactors derived from tyrosine, such as pyrroloquinoline quinone.
Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Nanoteknologi och funktionella material. (Nanoteknologi och Funktionella Material) ...
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June 16, 2021: Announcement Party for A Writers Garden Literary Symposium 2021 and Luncheon. Private Home. Questions contact Betty Suellentrop [email protected] June 25: Pot of Gold Luncheon featuring Best-selling author Josh Shipp benefiting Rainbow Days, Inc. Kyle Coots, co-founder and managing director of Miramar Equity Partners and Ross DeRogatis, president and owner of Matrix Orthopedics, Chairs.. * To see your event listed here, click here for Submission Guidelines.. ...
E.P.I.C Pride, Highlighting the latest LGBTQ news in Entertainment, Politics, International affairs, and Culture. - Caitlyn Jenner Running For California.... Read more ...
Title:Hydroxysafflor Yellow A Attenuates Renal Ischemia- Reperfusion Injury in a Rat Model. VOLUME: 9 ISSUE: 10. Author(s):Weiran Chai, Wenhui Zhang, Zhu Jin, Yanqian Zheng, Peiyao Jin, Qiaoyan Zhang and Jianming Zhi. Affiliation:Department of Physiology, Shanghai Jiaotong University, School of Medicine, Chongqing South Road 280, Shanghai 200025, China.. Keywords:Hydroxysafflor yellow A, Ischemia/reperfusion injury, Renal, Antioxidant enzymes, Malondialdehyde, Myeloperoxidase, hemorrhagic shock, Carthamus tinctorius, renal I/R, Acute renal failure. Abstract:Hydroxysafflor Yellow A (HSYA) is one of the most important active ingredients of Carthamus tinctorius L, and has long been widely used in the treatment of cardiovascular diseases in China. The purpose of this study was to evaluate the role of HSYA in protecting the kidney against ischemia/reperfusion injury (IRI). Male Wistar albino rats (200-250 g) were unilaterally nephrectomized and subjected to 45-min renal ischaemia and 24-h ...
Water soluble quinones are a group of cytotoxic anti-bacterial compounds that are secreted by many species of plants, invertebrates, fungi and bacteria. Studies in a number of species have shown the importance of quinones in response to pathogenic bacteria of the genus Pseudomonas. Two electron reduction is an important mechanism of quinone detoxification as it generates the less toxic quinol. In most organisms this reaction is carried out by a group of flavoenzymes known as NAD(P)H quinone oxidoreductases. Azoreductases have previously been separate from this group, however using azoreductases from Pseudomonas aeruginosa we show that they can rapidly reduce quinones. Azoreductases from the same organism are also shown to have distinct substrate specificity profiles allowing them to reduce a wide range of quinones. The azoreductase family is also shown to be more extensive than originally thought, due to the large sequence divergence amongst its members. As both NAD(P)H quinone oxidoreductases and
CD20 is a B cell-specific 35/37 kDa integral membrane protein which modulates proliferation and differentiation of normal resting B cells when stimulated by CD20 antibodies. An increase in c-myc mRNA levels occurs within hours after treatment of resting B cells with CD20 mAb; however earlier events in the CD20 signal transduction pathway have not been described. Here we demonstrate that anti-CD20 mediated induction of c-myc mRNA is inhibited by the tyrosine kinase inhibitor herbimycin A, that CD20 is associated with both tyrosine and serine kinase activity, and that tyrosine phosphorylation of multiple substrates is induced within minutes upon ligation of CD20 with mAb. Association of the tyrosine and serine kinases with CD20 was stable in lysis buffer containing 1% NP40 and 0.25% deoxycholate. Under the same conditions, antibodies against several other B cell surface molecules failed to co-precipitate tyrosine kinase activity, however, a serine kinase was precipitated by the anti-CD19 mAb, B43. ...
Abstract Alanine triazole Mn-catalyzed 1,6-conjugate coupling/aromatization of para-quinone methides was developed with good to high yields under mild conditions. This protocol provided an efficient and practical route to the synthetically interesting functionalized methines and their analogues. Preliminary mechanistic experiments revealed 1,6-conjugate addition of nucleophiles to para-quinone methides (p-QMs). The manganese was acted as the Lewis acid.. ...
Chemical behavior of the oxopurines 8-oxoadenosine and 8-oxoinosine has been investigated. Purine quinones, pivotal intermediates in oxidation of oxopurines were successfully trapped and the resulting products were characterized. Formation of purine quinones was demonstrated with both chemical and photochemical oxidizing agents. Adducts formed as a result of reaction of purine quinones with nucleophiles were isolated and characterized. Pyrene dihydrodioxins have been synthesized and shown to be effective agents for release of pyrene-4,5-dione. Pyrene-4,5-dione is an effective DNA photo-oxidation agent. Pyrene dihydrodioxin incorporating a pyridinium salt as a possible internal electron trap has been shown to release pyrenequinone rapidly. Dihydrodioxins containing two pyridine and pyridinium salt moieties have been synthesized and characterized by variety of methods including 1H and 13C NMR spectroscopy. Dihydrodioxin containing two pyridine moieties was separated into D and L enantiomers via liquid
Understanding the Complexity of Estrogen Detoxification: How Genetics, the Liver, and the Microbiome Come Together. By: Dr. Carrie Jones, ND, MPH. Sponsored By: Precision Analytical. ​. Estrogen goes through phase 1 and phase 2 detoxification known collectively as estrogen metabolism. Once water soluble, estrogen must leave the cell and enter phase 3 detoxification. A healthy metabolism shunts estrogen into 2-OH-E1 and then through methylation via COMT into 2-methoxy-E1 for proper disposal from the body. Unfortunately, if the pathway turns towards the unhealthy 4-OH-E1 or does not go through methylation, those estrogens go on to form a quinone that can result in DNA damage and increased cancer risk. Certain enzymes, such as Quinone Reductase and Glutathione-S-Transferase, help prevent or reverse quinone formation and can be optimized with specific dietary changes and natural products. It is also important to evaluate the gut as the microbiome has a huge influence on b-glucuronidase and the ...
Welcome to the Taberhood, Quinones family! New homebuyer Eric Quinones found his home in Ponderosa Estates in Piedmont, Oklahoma.My name is Eric. We live in the Ponderosa addition off of 122nd and Council Road. We wanted to build a house from the ground up, so that way it could be very customized to us and meet all of our needs.We have a lot of children. We have five kids and we wanted to be able to put all five children in their own space, so they could have their own room. Building from the
Fingerprint Dive into the research topics of Cytochrome P450 isoforms catalyze formation of catechol estrogen quinones that react with DNA. Together they form a unique fingerprint. ...
Studies toward the Total Synthesis of Parvifolals A/B: An Intramolecular o‑Quinone Methide [4 + 2]-Cycloaddition To Construct the Central Tetracyclic Core
Looking for online definition of Sphingobacterium in the Medical Dictionary? Sphingobacterium explanation free. What is Sphingobacterium? Meaning of Sphingobacterium medical term. What does Sphingobacterium mean?
Role of nicotinamide quinone oxidoreductase 1 (NQO1) in protection against toxicity of electrophiles and reactive oxygen intermediates
We demonstrate a proof of principle for a new approach in the development of a drug delivery system. A positively charged prodrug (phenol) can form a stable inclusion complex with CB[7], which enables more efficient delivery of the prodrug. After photochemical transformation (photoactivation) inside the comp Supramolecular chemistry in OBC
Amino-acid radical enzymes have been studied extensively for 30 years but the experimental barriers to determine the thermodynamic properties of their key radical cofactors are so challenging that only a handful of reports exist in the literature. This is a major drawback when trying to understand the long-range radical transfer and/or catalytic mechanisms of this important family of enzymes. Here this issue is addressed by developing a library of well-structured model proteins specifically designed to study tyrosine and tryptophan radicals. The library is based on a 67-residue three-helix bundle (α3W) and a 117-residue four-helix bundle (α4W). α3W and α4W are single-chain and uniquely structured proteins. They are redox inert except for a single radical site (position 32 in α3W and 106 in α4W). Papers I and II describe the design process and the protein characteristics of α4W as well as a voltammetry study of its unique tryptophan. Paper III and V describe two projects based on α3C, ...
56815-78-2 - UMOZFNODOJXMKD-UHFFFAOYSA-J - Platinum (IV), bis(cyclopentylammine)tetrachloro-, cis- - Similar structures search, synonyms, formulas, resource links, and other chemical information.
Posted on November 9, 2012 by Sam Quinones. One story that emerged from the Tell Your True Tale writing workshops I did with students at San Joaquin Delta College in Stockton was Saturday …. By Alexandria Hendon. …That year we moved in with him, he and I were inseparable, but it hadnt always been that way. He denied me as his daughter several times. He had come and gone as he pleased. Each time he decided he wanted to be around my mom, my brothers, and me, he stayed around for a week or so. In that week, he would take us to dinner, zoos, and riding in go-carts. Then we wouldnt see him for months. Every time he left, I would lose a dad all over again.. As I grew older, I learned that every time he left, he had gotten some girl pregnant. As far as I know, we have four half brothers and one half sister. My mom and dad would always fight, mainly because of his cheating, but for some reason, she would always take him back. …. Continue Reading ...
[65 Pages Report] Check for Discount on TETRAHYDROXY-1,4-QUINONE HYDRATE Global Market and Forecast Research report by ChemReport. DescriptionWe provide independent and unbiased information on manufacturers, prices, production...
Perhaps less lighthearted than previous April Fools posts, this one reflects my continuing frustration with some of the (to put it politely) refuse published in the literature. Compound 1 is a known hydrogen-peroxide generator (which would inactivate cysteine proteases) and compound 2 is an electrophilic rhodanine (which Jonathan Baell has memorably referred to as polluting the literature). I added the catechol (which can form reactive ortho-quinones) in compound 4 just to push things completely over the top ...
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Supplementary MaterialsAdditional document 1: Shape S1. epidermis to regulate sclerotization. Figure S7. Sclerotization, quantified using other protein bands, show that RK function is necessary but not sufficient in the CNS to regulate sclerotization. Figure S8. Abdominal pigmentation in males in which Tubastatin A HCl inhibitor RK function was downregulated in peptidergic, CCAP, and ILP7 neurons. Figure S9. RK function is necessary in peptidergic neurons that are not CCAP immunopositive to regulate melanization. Figure S10. Some ILP7-immunopositive neurons express knockdown efficiency. (PDF 10369 kb) 12915_2020_742_MOESM1_ESM.pdf (10M) GUID:?46894A39-2E1B-47AE-807B-007034AF033B Data Availability StatementAll data generated or analyzed during this study are included in this published article and its supplementary information files. Abstract Background In insects, continuous growth requires the periodic replacement of the exoskeleton. Once the remains of the exoskeleton from the previous stage ...
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1K6L: The structure of a mutant photosynthetic reaction center shows unexpected changes in main chain orientations and quinone position.
It has been established earlier that lipids (phosphatidyl glycerol, phosphatidyl inositol, cardiolipin) being subjected to radiolysis undergo fragment..
Shes awesome. Very professional. She takes direction well and submits flawless work, always. If you are able to use her for any of your projects, do so! She was in a project I did for an RPG Maker game a few years ago and she was stellar! I hope I do a project where I can utilize her again ...
I am a freelance illustrator known to reside somewhere within the six states of New England -and New York too. Im currently settled in a cozy little nook in Somerville, Massachusetts. True. Email: me at joequinones dot ...
Institutions of higher education continue to be economic drivers, not just in Westchester County, but across New York state. Private not-for-profit colleges and universities in ...
Display omitted] New sesquiterpene quinones, metachromins X (1) and Y (2), together with the known metachromins C (3), J (4), and T (5), were isolated as ...
White Out Medical Peel contains natural quinones to help inhibit production of new pigmentation, leaving the skin smoother, brighter and even in color.
Contenay-Quinones is the daughter of Carmen Quinones, a painter from Lima, Peru and was influenced by a wide variety of music ... In 2000, Quinones provided vocals on the Dario G song "Voices" on the soundtrack to the Leonardo DiCaprio film The Beach. In ... June 2011, Quinones released a specially written song "Show Me How" for the Vinyl Japan/Red Cross charity album for children ... Vanessa Contenay-Quinones (born Vanessa Lydia Eve Contenay in Paris, France) is a London-based singer-songwriter from Paris. ...
While Quinones had been relegated to a minor role under Alvarado, once Quinones became acting Chancellor he removed several ... saying that Quinones' "sedate kind of style" had hurt him from a political standpoint. Quinones expressed tremendous relief ... Quinones died at age 79 on July 25, 2010, in Manhasset, New York from a stroke. He was survived by his wife, the former Romana ... Quinones was born on October 12, 1930, in East Harlem and attended the High School of Commerce. He decided to attend college " ...
The surname Quinones is of Spanish language origin. In Spanish, it is spelled Quiñones. Sam Quinones (/kiˈnjoʊ.neɪs/ kee-NYOH- ... Quinones, Sam. "Op-Ed The truth is immigrants have let us live like princes". LA Times. Retrieved 31 January 2017. Quinones, ... "About - Sam Quinones". Sam Quinones Official Website. Retrieved 3 March 2017. Wiggin, Sally. "State of Addiction: How did ... "Sam Quinones". Columbia Journalism School. Retrieved May 23, 2013. Miller, Wendy. "Opium Dreamland: Reporter Sam Quinones on ...
... was born in New York City to Marjorie Bayne Quinones and Jose Quinones. She has a twin sister, ... Karen E. Quinones. "Summer 2006 : Ditching Self-Doubt - by Karen E. Quinones". Realhealthmag.com. Retrieved 26 November 2014. " ... Official Page for Karen E. Quinones Miller Karen E. Quinones Rants and Raves Blog (Articles with short description, Short ... Karen E. Quinones Miller (born June 20, 1958, New York, United States) is an American journalist, historian, and nationally ...
4-quinone"). Quinone methide - where one O is replaced by C Xylylene - where both O's are replaced by C's Quinone imine - where ... The quinone acts as the dienophile and reacts with a diene at a carbon-carbon double bond. In Diels-Alder reactions quinones ... Numerous quinones are significant roles in biology. Vitamin K, which involved in coagulation of blood, is a quinone. Ubiquinone ... In alkaline conditions, quinones undergo a reversible single-step, two-electron reduction. In neutral conditions, quinones may ...
... (PQQ), also called methoxatin, is a redox cofactor and antioxidant. Produced by bacteria, it is found ... PqqB (P07779) oxidizes the 2 and 3 positions on the tyrosine ring, forming a quinone which quickly becomes AHQQ, finishing the ... An article by Bruce Ames in The Proceedings of the National Academy of Sciences in 2018 identified pyrroloquinoline quinone as ... "Pyrroloquinoline quinone (HMDB13636)". Human Metabolome Database. University of Alberta. Retrieved 19 July 2015. Enzymes ...
... s are more polar than quinones, and therefore more chemically reactive. Simple unhindered quinone methides are ... A quinone dimethide (or "xylylene") is a compound with the formula C6H4(=CH2)2. Thus they are related to quinone monomethides ( ... Quinone methides are often prepared by oxidation of the corresponding ortho or para cresol. Quinone methides can be produced in ... Quinone Methides in Lignification Wang P, Song Y, Zhang L, He H, Zhou X (2005). "Quinone methide derivatives: important ...
Alcohol+dehydrogenase+(quinone) at the US National Library of Medicine Medical Subject Headings (MeSH) Portal: Biology (CS1: ... Alcohol dehydrogenase (quinone) (EC, type III ADH, membrane associated quinohaemoprotein alcohol dehydrogenase) is an ... Matsushita K, Kobayashi Y, Mizuguchi M, Toyama H, Adachi O, Sakamoto K, Miyoshi H (October 2008). "A tightly bound quinone ... Reactivity with ubiquinone of pyrroloquinoline quinone-dependent alcohol dehydrogenases purified from Acetobacter aceti and ...
Other names in common use include thiosulfate:quinone oxidoreductase, thiosulphate:quinone oxidoreductase, thiosulfate ... This enzyme belongs to the family of oxidoreductases, specifically those acting on a sulfur group of donors with a quinone or ... In enzymology, a thiosulfate dehydrogenase (quinone) (EC is an enzyme that catalyzes the chemical reaction 2 ... quinone oxidoreductase". Mol. Microbiol. 53 (4): 1147-60. doi:10.1111/j.1365-2958.2004.04193.x. PMID 15306018. Portal: Biology ...
... quinone reductase 2, N-ribosyldihydronicotinamide dehydrogenase (quinone), and NAD(P)H:quinone oxidoreductase2 (misleading). ... Other names in common use include NRH:quinone oxidoreductase 2, NQO2, NQO2, NAD(P)H:quinone oxidoreductase-2 (misleading), QR2 ... S; Knox, R; Sun, XZ; Joseph, P; Jaiswal, AK; Zhang, D; Deng, PS; Chen, S (1997). "Catalytic properties of NAD(P)H:quinone ... Jaiswal AK (1994). "Human NAD(P)H:quinone oxidoreductase2. Gene structure, activity, and tissue-specific expression". J. Biol. ...
In enzymology, a pyrroloquinoline-quinone synthase (EC is an enzyme that catalyzes the chemical reaction 6-(2-amino-2 ... Klinman JP, Schwarzenbacher R (2004). "Quinone biogenesis: Structure and mechanism of PqqC, the final catalyst in the ... "The structure of a biosynthetic intermediate of pyrroloquinoline quinone (PQQ) and elucidation of the final step of PQQ ... "Sequence analysis of pqq genes required for biosynthesis of pyrroloquinoline quinone in Methylobacterium extorquens AM1 and the ...
This region of the protein is also thought to mediate quinone binding. Regarding the C-terminal domain, much of its structural ... Class 2 dihydroorotate dehydrogenases (DHOQO, EC is an enzyme with systematic name (S)-dihydroorotate:quinone ... This enzyme catalyses the electron transfer from dihydroorotate (electron donor) to a quinone (electron acceptor): (S)- ... DOI: 10.1107/S0907444905042642 Dihydroorotate+dehydrogenase+(quinone) at the US National Library of Medicine Medical Subject ...
... (EC, NAD(P)+-independent quinate dehydrogenase, quinate:pyrroloquinoline-quinone 5- ... Quinate+dehydrogenase+(quinone) at the US National Library of Medicine Medical Subject Headings (MeSH) Portal: Biology ( ... This enzyme catalyses the following chemical reaction quinate + quinone ⇌ {\displaystyle \rightleftharpoons } 3-dehydroquinate ...
Pyruvate+dehydrogenase+(quinone) at the US National Library of Medicine Medical Subject Headings (MeSH) Portal: Biology (EC 1.2 ... Pyruvate dehydrogenase (quinone) (EC, pyruvate dehydrogenase, pyruvic dehydrogenase, pyruvic (cytochrome b1) ...
In enzymology, a hydrogen:quinone oxidoreductase (EC is an enzyme that catalyzes the chemical reaction H2 + quinone ... and quinone-reactive Ni/Fe-hydrogenase. E, Duchene A, Tripier D, Juvenal K, et al. (1992). "The quinone-reactive Ni/Fe- ... 1993). "The quinone-reactive Ni/Fe-hydrogenase of Wolinella Succinogenes". Eur. J. Biochem. 214 (3): 949-50. doi:10.1111/j.1432 ... The quinone can be menaquinone, ubiquinone, demethylmenaquinone or methionaquinone. This enzyme belongs to the family of ...
In enzymology, a NADPH dehydrogenase (quinone) (EC is an enzyme that catalyzes the chemical reaction NADPH + H+ + ... The systematic name of this enzyme class is NADPH:(quinone-acceptor) oxidoreductase. Other names in common use include reduced ... nicotinamide adenine dinucleotide phosphate (quinone), dehydrogenase, NADPH oxidase, and NADPH2 dehydrogenase (quinone). It has ...
... reduced quinone Thus, the two substrates of this enzyme are (S)-malate and a quinone, whereas its two products are oxaloacetate ... This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with a quinone as ... The systematic name of this enzyme class is (S)-malate:quinone oxidoreductase. Other names in common use include FAD-dependent ... In enzymology, a malate dehydrogenase (quinone) (EC, formerly malate dehydrogenase (acceptor) (EC, is an ...
Once the electrons are in the quinone, they are transported to the quinone pool. The quinone pool is located inside the ... Sulfide:quinone reductase (SQR , EC is an enzyme with systematic name sulfide:quinone oxidoreductase. This enzyme ... quinone oxidoreductase. In both cases, the electrons are shuttled to the quinone pool, then to cytochrome c oxidase where the ... while the re side of FAD is connected to a disulfide bridge and donates electrons to the quinone. 2, 3 The quinone is ...
The systematic name of this enzyme class is NADPH:quinone oxidoreductase. This enzyme is also called NADPH2:quinone reductase. ... A novel NADPH:quinone oxidoreductase". J. Biol. Chem. 267 (1): 96-102. PMID 1370456. Portal: Biology v t e (EC 1.6.5, NADPH- ... This enzyme belongs to the family of oxidoreductases, specifically those acting on NADH or NADPH with a quinone or similar ... In enzymology, a NADPH:quinone reductase (EC is an enzyme that catalyzes the chemical reaction NADPH + H+ + 2quinone ...
Other names in common use include reduced nicotinamide adenine dinucleotide (quinone) dehydrogenase, NADH-quinone ... a quinone ⇌ {\displaystyle \rightleftharpoons } NAD+ + a quinol The 3 substrates of this enzyme are NADH, H+, and a quinone ( ... In enzymology, a NADH dehydrogenase (quinone) (EC is an enzyme that catalyzes the chemical reaction NADH + H+ + ... The systematic name of this enzyme class is NADH:(quinone-acceptor) oxidoreductase. ...
Nitrate+reductase+(quinone) at the US National Library of Medicine Medical Subject Headings (MeSH) Portal: Biology (EC 1.7.5). ... Nitrate reductase (quinone) (EC, nitrate reductase A, nitrate reductase Z, quinol/nitrate oxidoreductase, quinol- ... Enoch HG, Lester RL (December 1974). "The role of a novel cytochrome b-containing nitrate reductase and quinone in the in vitro ... a quinone + H2O This is a membrane-bound enzyme which supports [anaerobic respiration] on nitrate. ...
Portal: Biology v t e (EC 1.2.99, Pyrroloquinoline quinone enzymes, Enzymes of unknown structure, All stub articles, EC 1.2 ... In enzymology, an aldehyde dehydrogenase (pyrroloquinoline-quinone) (EC is an enzyme that catalyzes the chemical ... The systematic name of this enzyme class is aldehyde:(pyrroloquinoline-quinone) oxidoreductase. This enzyme is also called ...
... is an indolequinone, a chemical compound found in the oxidative browning reaction of fruits like bananas ... Like many quinones it can undergo redox reactions via the corresponding 5,6-dihydroxyindole. Dopachrome Molecular Basis of ...
... quinone oxidoreductase. This enzyme catalyses the following chemical reaction cyclic alcohol + quinone ⇌ {\displaystyle \ ... Cyclic alcohol dehydrogenase (quinone) (EC, cyclic alcohol dehydrogenase, MCAD) is an enzyme with systematic name ... Cyclic+alcohol+dehydrogenase+(quinone) at the US National Library of Medicine Medical Subject Headings (MeSH) Portal: Biology ( ...
H-quinone dehydrogenase, NAD(P)H-quinone oxidoreductase, NAD(P)H: (quinone-acceptor)oxidoreductase, NAD(P)H: menadione ... quinone), DT-diaphorase, flavoprotein NAD(P)H-quinone reductase, menadione oxidoreductase, NAD(P)H dehydrogenase, NAD(P)H ... quinone), NQO1, QR1, and NAD(P)H:(quinone-acceptor) oxidoreductase. This enzyme participates in biosynthesis of steroids. It ... In enzymology, a NAD(P)H dehydrogenase (quinone) (EC is an enzyme that catalyzes the chemical reaction NAD(P)H + H+ + ...
In enzymology, a glucose 1-dehydrogenase (FAD, quinone) (EC is an enzyme that catalyzes the chemical reaction D- ... the two substrates of this enzyme are D-glucose and a quinone, whereas its two products are D-glucono-1,5-lactone and a quinol ... glucose + a quinone ⇌ {\displaystyle \rightleftharpoons } D-glucono-1,5-lactone + a quinol Thus, ...
... (EC, DadA) is an enzyme with systematic name D-amino acid:quinone oxidoreductase ( ... D-amino+acid+dehydrogenase+(quinone) at the US National Library of Medicine Medical Subject Headings (MeSH) Portal: Biology v t ... deaminating). This enzyme catalyses the following chemical reaction D-amino acid + H2O + quinone ⇌ {\displaystyle \ ...
... is a membrane-bound protein complex present in the electron transport chain ...
Glycerol-3-phosphate dehydrogenase (EC is an enzyme with systematic name sn-glycerol 3-phosphate:quinone oxidoreductase ... This enzyme catalyses the following chemical reaction sn-glycerol 3-phosphate + quinone ⇌ {\displaystyle \rightleftharpoons } ...
... quinone oxidoreductase 1 (NQO1, DT-diaphorase), functions and pharmacogenetics". Quinones and Quinone Enzymes, Part B. Methods ... NQO1 removes quinone from biological systems through detoxification reaction: NAD(P)H + a quinone → NAD(P)+ + a hydroquinone. ... This enzyme facilitates the two electron reduction of quinone to hydroquinone. NQO1-mediated two electron reduction of quinone ... NQO1 plays a role in ubiquinone and vitamin E quinone metabolism. These quinones protect cellular membranes from peroxidative ...
Quinone. CAS No: 106-51-4. NOTE:. (1) Efficacy of Medical Tests has not been evaluated.. (2) NIOSH references include ... Quinone. Editor(s). /Author(s). Specific Medical Test(s) or Examination(s). Reference(s). ...
Javier Quinones may only conduct securities business with residents of states in which the advisor is properly registered. ... Contact Javier Quinones. Lets meet to discuss whats most important to you. ... https://www.ameripriseadvisors.com/javier.a.quinones/?openFormModal=newsletter-signup Ameriprise Financial Services, LLC. ...
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Pearls From: Alfredo Quinones, MD. - Harnessing electromagnetism and immune cells to treat brain cancer. by Kristina Fiore, ... Whats coming down the pike in brain cancer treatment? In this exclusive MedPage Today video, Alfredo Quinones, MD, chair of ...
Lee Quinones - The leading online destination for mens contemporary fashion and streetwear. Shop at our store and also enjoy ...
Sign up for Deezer for free and listen to Joey Quinones: discography, top tracks and playlists. ...
Eva Quinones. Guest Author. Eva Quinones (@em_quinones) is a J.D. student at NYU School of Law and a Ph.D. candidate in ...
Archives for Indo Quinones. [LISTEN] YWCA Jamestowns Broadscast: Ep 10 - The Housing Crisis in Jamestown & Chautauqua County. ... Filed Under: Audio Tagged With: Alize Scott, Cienna Simon, Haudenosaunee, Hillary Belin, Indo Quinones, Kaycee Colburn, Seneca ... Filed Under: Audio Tagged With: Alize Scott, Broadscast Radio Show, Cienna Simon, Hillary Belin, Indo Quinones, Linda Cecchetti ... Filed Under: Audio Tagged With: Alize Scott, Cienna Simon, Hillary Belin, Indo Quinones, Sukanya Burman, sukanya burman dance ...
Phalen Lake Hmong Studies Magnet. May Lee Xiong, Principal , 1089 Cypress Street, Saint Paul, MN 55106 , (651) 293-8935 , Get Directions. (651) 293-8935 , Get Directions. Principal/School Name , 360 Colborne Street, Saint Paul, MN, 55102 , 651-767-8100 , Get Directions Principal/School Name , 360 Colborne Street, Saint Paul, MN, 55102 ...
Find out when and where you can watch Tony Quinones movies and tv shows with the full listings schedule at TV Guide ... Add Tony Quinones to your Watchlist to find out when its coming back. ... There are no TV Airings of Tony Quinones in the next 14 days. ...
Sonia Quinones is a freelance content marketing writer and strategist who works with small and mid-sized businesses. Learn more ... Sonia Quinones Sonia Quinones is a freelance content marketing writer and strategist who works with small and mid-sized ... Recent Articles Published by Sonia Quinones. starting. How to Start a Luxury Day Spa. Wondering how to start a day spa? The spa ...
Carlos Quinones net worth, bio and Orion Engineered Carbons Sa. insider trades. ... What is Carlos Quinoness Past Insider Trading?. Carlos Quinoness largest purchase order was 3,600 units , worth over $47.66K ... Carlos Quinoness largest sale order was 3,410 units , worth over $51.6K on February 25, 2022. In total, Carlos Quinones has ... VP Global Operations, Carlos Quinones, is estimated to be about $799.97K . Carlos Quinones owns about 47,105 units of Orion ...
Credits for Joe Quinones on Spider-Man related comics and items from our database. ...
As Sam Quinones was researching Americas opiate epidemic for his award-winning 2015 book Dreamland, he watched a troubling ... Sam Quinoness new book is "The Least of Us: True Tales of America and Hope in the Time of Fentanyl and Meth.". (Photo of Sam ... Sam Quinones. , author, "The Least of Us: True Tales of America and Hope in the Time of Fentanyl and Meth." His previous books ... Quinones joins us to talk about the devastating impact of the synthetic drug era, as told in his new book "The Least of Us," ...
This website is for informational and/or entertainment purposes only and is not a substitute for medical advice, diagnosis, or treatment ...
Compare: Alcatel A30 Plus vs KIN One. +. Compare the Alcatel A30 Plus and KIN One below. We pit the Alcatel A30 Plus vs KIN One ...
Pyrroloquinoline quinone) is an important antioxidant that promotes the creation of new mitochondria, supports heart health and ... Jarrow Formulas PQQ (Pyrroloquinoline quinone) is an important antioxidant that promotes the creation of new mitochondria, ...
09/02/15 Sam Quinones. Wed - Sam Quinones author of Dream Land 2/5 ...
... November 11, 2010. by Kelly Hodgkins - 1 Comment ... This is a bit of a shocker but apparently the ill-fated Kin ONE and TWO are slated to re-launch with Verizon in Q4 2010. This ...
... news and notes on Lester Quinones of the Golden State ... Lester Quinones. Follow teamUnfollow team. #25, SG. , Golden ...
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Meet Kim Quinones, since 2013 Kim has been helping people find and heal their stuck places, acknowledge their shadows and ... Meet Kim Quinones, since 2013 Kim has been helping people find and heal their stuck places, acknowledge their shadows and ...
Quinone reductase. Timeline for Protein NAD(P)H:quinone reductase from c.23.5.3: Quinone reductase: *Protein NAD(P)H:quinone ... Protein NAD(P)H:quinone reductase from c.23.5.3: Quinone reductase appears in SCOPe 2.07. ... Lineage for Protein: NAD(P)H:quinone reductase. *Root: SCOPe 2.08 *. Class c: Alpha and beta proteins (a/b) [51349] (148 folds) ... More info for Protein NAD(P)H:quinone reductase from c.23.5.3: ... Family c.23.5.3: Quinone reductase [52235] (4 proteins). binds ...
Nachrichten und Infos zu Lester Quinones, Golden State ... Lester Quinones. Follow teamUnfollow team. #25, SG. , Golden ...
  • The Magic worked out Memphis guard Lester Quinones over the weekend, according to Jake Weingarten of StockRisers.com ( Twitter link ). (hoopsrumors.com)
  • Jarrow Formulas PQQ (Pyrroloquinoline quinone) is an important antioxidant that promotes the creation of new mitochondria, supports heart health and cognitive function. (netrition.com)
  • Are you thinking of consuming pyrroloquinoline quinone powder? (grannymed.com)
  • Pyrroloquinoline quinone has many medicinal properties for the brain as well as the body. (grannymed.com)
  • if a patient crosses this parameter, then he/she bears the bad effects, the same condition is with the pyrroloquinoline quinone powder. (grannymed.com)
  • Some essential aspects that you should know before starting the consumption of pyrroloquinoline quinone. (grannymed.com)
  • When you are purchasing the pyrroloquinoline quinone, then there will be something that will have detail about the consumption. (grannymed.com)
  • The price of the pyrroloquinoline quinone may vary according to the brands. (grannymed.com)
  • Many people may think if they have started taking the pyrroloquinoline quinone, they will have a miracle in terms of memory within some days. (grannymed.com)
  • Whatever the medicinal properties compound we are taking, whether it is pyrroloquinoline quinone or nootropics, we should use it with the proper dosage and should wait for the results. (grannymed.com)
  • the Cofttek PQQ supplement is one of the best Pyrroloquinoline Quinone supplements currently available in the market. (cofttek.com)
  • Pyrroloquinoline Quinone or PQQ is a compound that exists in plants as well as many bacteria and single-cell eukaryotes, such as yeast. (cofttek.com)
  • For many years, researchers thought Pyrroloquinoline Quinone ( PQQ ) is a type of vitamin. (cofttek.com)
  • However, research done over the last few years has revealed that Pyrroloquinoline Quinone is a nutrient with vitamin-like qualities that has the capacity to act as a co-factor or enzyme booster in the reduction-oxidation process which involves the transfer of electrons between two species. (cofttek.com)
  • It is these important facts that have caused a sudden rise in the popularity of Pyrroloquinoline quinone in recent years. (cofttek.com)
  • What does pyrroloquinoline quinone do? (cofttek.com)
  • In addition to being a plant growth factor and bacterial cofactor, pyrroloquinoline quinone (PQQ) protects the mitochondria from oxidative stress and promotes mitochondriogenesis. (cofttek.com)
  • So far no upper or lower limit has been established on Pyrroloquinoline Quinone (PQQ) dosage. (cofttek.com)
  • Differential expression of basal and hydrocarbon-induced cytochrome P-450 monooxygenase and quinone reductase activities in subpopulations of murine epidermal cells differing in their stages of differentiation. (aspetjournals.org)
  • Genetic susceptibility of postmenopausal osteoporosis on sulfide quinone reductase-like gene. (cdc.gov)
  • About the Book In this somewhat strange, completely original volume Peter Quinones invites the reader to try out hundreds of "story openers" with the following question in mind - If you started reading a story, and this was the first sentence, would you want to continue reading? (wright-spot.com)
  • Quinones are produced in organisms and are utilized as electron transfer agents, pigments and in defence mechanisms. (st-andrews.ac.uk)
  • The electron transfer in the free bases of these chlorin- and bacteriochlorin-quinones ist about five times faster than in the corresponding porphyrin-quinone. (fu-berlin.de)
  • The kinetics of the triplet electron transfer were studied on a cyclohexylene-linked Zn(II)-chlorin-quinone in ethanol glass matrix at 130 K. (fu-berlin.de)
  • As Sam Quinones was researching America's opiate epidemic for his award-winning 2015 book "Dreamland," he watched a troubling phenomenon emerge. (kqed.org)
  • Two meso-substituted chlorin-quinones, linked via the chlorin-positions 5 and 10, and a bacteriochlorin-quinone were obtained by reduction of a porphyrin- hydroquinone with diimine, followed by selective oxidation of the hydroquinone moiety with p--benzoquinone. (fu-berlin.de)
  • Quinones joins us to talk about the devastating impact of the synthetic drug era, as told in his new book "The Least of Us," and how communities are trying to recover. (kqed.org)
  • Just as critical as the outcome of the alternative study is the choice of language, drawing distinctions between 6ppd, 6ppd-quinone and tire road wear particles. (rubbernews.com)
  • Determination of four quinones in diesel exhaust particles, SRM 1649a, and atmospheric PM2.5. (cdc.gov)
  • A quantitative method for the determination of four quinones was developed using diesel exhaust particles (DEP) and National Institute of Standards and Technology (NIST) Standard Reference Material (SRM) 1649a. (cdc.gov)
  • And TRWP, which can contain 6ppd-quinone that ultimately finds its way into urban runoff, is 50-percent tire tread and 50-percent road surface. (rubbernews.com)
  • Credits for Joe Quinones on Spider-Man related comics and items from our database. (spiderfan.org)
  • Sonia Quinones is a freelance content marketing writer and strategist who works with small and mid-sized businesses. (bplans.com)
  • Here, we have analyzed the properties of 990 different quinones of various biological sources through a computation approach to determine their standard reduction potentials and aqueous solubility. (st-andrews.ac.uk)
  • The screening was performed using the PBE functional and the 6-31G** basis set, providing a distribution of reduction potentials of the naturally occurring quinones varying from − 1.4 V to 1.5 V vs. the standard hydrogen electrode. (st-andrews.ac.uk)
  • Our study shows that the group containing the quinones of fungal origin, which is also the largest of the groups considered, has the largest antimicrobial and electrochemical potential, when considering the distribution of reduction potentials for the compounds. (st-andrews.ac.uk)
  • I. Quinone domains and excitation transfer in chromatophores and reaction center.antenna complexes. (harvard.edu)
  • Isolated complexes of the reaction center (RC) with its core antenna ring (light-harvesting complex 1 (LH1)) were studied in their dimeric (native) form or as monomers with respect to excitation transfer and distribution of the quinone pool. (harvard.edu)
  • IMSEAR at SEARO: Reaction of methionine with some biologically important o-quinones. (who.int)
  • Recent studies have also shown that quinones can be utilized in flow battery technology, though naturally occurring quinones have not yet been investigated. (st-andrews.ac.uk)
  • Meet Kim Quinones, since 2013 Kim has been helping people find and heal their stuck places, acknowledge their shadows and reveal their inner light. (bestpsychicdirectory.com)
  • Twelfth-graders Louis Quinones, 18, and Elway Tubbs, 18, sign letters of intent May 6 at Vista Ridge High School. (d49.org)
  • Furthermore, naturally occurring quinones can also be cytotoxins with antibacterial properties. (st-andrews.ac.uk)
  • The charge-separated state tends to be more long-lived in chlorin-quinones linked via chlorin-position 10, confirming the predictions from the semiempirical calculations in part. (fu-berlin.de)
  • Discovering how 6ppd-quinone forms-the USTMA correctly notes that greener road construction, with gutters or other avenues for roadway runoff, should be part of the overall conversation-and finding an alternative to the foundational additive 6ppd are critical issues. (rubbernews.com)
  • While the USTMA, in making cryo-milled TRWP available for study, is prioritizing how 6ppd-quinone forms, the fact that 6ppd-quinone exists at all (and contains 6ppd) is driving the DTSC in its process. (rubbernews.com)
  • Boxer Luis Quinones died Thursday night at the age of 25, five days after losing a bout in Colombia. (larrybrownsports.com)
  • By 2017, traffickers got sophisticated and began making fentanyl pills, "what we're seeing now by the millions," noted Quinones. (nih.gov)
  • Pete Quinones has hosted his show since July 2017 (formerly titled Free Man Beyond the Wall) and has concentrated on topics pertaining to liberation from tyrannical government. (libsyn.com)
  • Disruption of the NAD(P)H:quinone oxidoreductase 1 (NQO1) gene in mice causes myelogenous hyperplasia. (nih.gov)
  • Deficiency of NRH:quinone oxidoreductase 2 increases susceptibility to 7,12-dimethylbenz(a)anthracene and benzo(a)pyrene-induced skin carcinogenesis. (nih.gov)
  • Pyrroloquinoline quinone was discovered as the third coenzyme for oxidoreductases next to nicotinamide adenine dinucleotide (NAD) and flavin adenine dinucleotide (FAD) in 1979. (mgc.co.jp)
  • In 2003, Researchers of Riken reported the possibility that Pyrroloquinoline quinone is the 14th vitamin in mammals. (mgc.co.jp)
  • Pyrroloquinoline quinone has potent anti-oxidative and nerve protective activities. (mgc.co.jp)
  • We have established our original manufacturing technology of Pyrroloquinoline quinone by fermentation of bacteria, and put it on the market as a research reagent. (mgc.co.jp)
  • Pyrroloquinoline quinone has great potential as a safe ingredient of dietary supplement for the brain. (mgc.co.jp)
  • Pyrroloquinoline quinone (PQQ), also called methoxatin, is a redox cofactor. (phcoker.com)
  • Pyrroloquinoline quinone is a pyrroloquinoline having oxo groups at the 4- and 5-positions and carboxy groups at the 2-, 7- and 9-positions. (phcoker.com)
  • As a redox agent, Pyrroloquinoline quinone is extremely stable and can participate in hundreds more reactions than other antioxidants, such as ascorbic acid, quercetin, and epicatechin. (phcoker.com)
  • Pyrroloquinoline quinone is a novel biofactor, and was recognized as an enzyme cofactor in bacteria. (phcoker.com)
  • Researchs show that Pyrroloquinoline quinone may have been present throughout early biological conception and evolution. (phcoker.com)
  • Pyrroloquinoline quinone is reported to participate in a range of biological functions with apparent survival benefits (e.g., improved neonatal growth and reproductive performance) in animals. (phcoker.com)
  • Moreover, Pyrroloquinoline quinone has antioxidant and B-vitamin-like activity, with a wide range of benefits for the brain and body. (phcoker.com)
  • Clinical studies in humans have shown that Pyrroloquinoline quinone enhances short-term memory and attention, improves energy metabolism and healthy aging, and reduces markers of inflammation, as well as improving general feelings of well-being. (phcoker.com)
  • Rat studies show impressive efficacy for Pyrroloquinoline quinone in stimulating mitochondrial biogenesis. (phcoker.com)
  • Experimental models of stroke and spinal cord injury show that Pyrroloquinoline quinone attenuates neuronal cell death, in part through Pyrroloquinoline quinone protecting N-methyl-d-aspartic acid (NMDA) receptors. (phcoker.com)
  • Rat models of Parkinson's disease show that Pyrroloquinoline quinone supplementation decreases neuronal loss, increases reactive oxygen species scavenging ability, and offersneuroprotection through additional mechanisms. (phcoker.com)
  • PQQ (pyrroloquinoline quinone) is an important antioxidant that promotes the creation of new mitochondria, along with supporting heart health and cognitive function. (org.ua)
  • To explore a novel AD treatment strategy with microdose lithium, we designed and synthesized a new chemical, tri-lithium pyrroloquinoline quinone (Li3PQQ), to study the synergistic effects of low-dose lithium and pyrroloquinoline quinone, a native compound with powerful antioxidation and mitochondrial amelioration. (nih.gov)
  • Our study demonstrated the efficacy of a novel AD therapeutic strategy targeting at multiple disease-causing mechanisms through the synergistic effects of microdose lithium and pyrroloquinoline quinone. (nih.gov)
  • AutismWonderland - written by Lisa Quinones-Fontanez - is a personal blog chronicling a NYC family's journey with autism, while also sharing local resources for children/families with special needs. (autismwonderland.com)
  • Ric Flair was involved in a massive argument in Puerto Rico with promoter Victor Quinones. (wrestling101.com)
  • Quinones are reactive organic compounds and are known to initiate reactions associated with many toxicological events. (cdc.gov)
  • Lack of quinone reductase activity suggests that amyloid-beta peptide/ERAB induced lipid peroxidation is not directly related to production of reactive oxygen species by redoxcycling. (ox.ac.uk)
  • The possibility that ERAB mediates quinone reduction is therefore investigated, thus giving the potential of redoxcycling and production of reactive oxygen species, leading to lipid peroxidation. (ox.ac.uk)
  • In the presence of transition metals or redox cycling compounds (including quinones), reactive oxygen species such as superoxide can be converted to the more reactive hydroxy radicals. (mingsheng88.org)
  • An undescribed Philippine marine sponge of the genus Xestospongia afforded four isoquinoline quinones: the new N-ethylene methyl ketone derivative of renierone (1), as well as the known compounds 1,6-dimethyl-7- methoxy-5,8-dihydroisoquinoline-5,8-dione (2), renierone (3), and mimosamycin (4). (strath.ac.uk)
  • A continuation of investigation into the possibility of relatively stable free radicals produced by quinone compounds, and their toxic effect on tumor cells. (nih.gov)
  • Manuel Quinones reports from Capitol Hill. (houstonpublicmedia.org)
  • Manuel Quinones reports from Washington. (houstonpublicmedia.org)
  • John Quinones aged 65 was born on 23 May 1952 in San Antonio, Texas as Juan Manuel Quinones. (wikinetworth.com)
  • He added that agency documents leaked earlier this year that showed the rule having a significant economic impact have 'no basis in fact'," Manuel Quinones reports for Environment & Energy News . (blogspot.com)
  • Novel tocopherol derivatives and tocopheryl quinone derivatives useful in the decrease of lysosomal substrate accumulation, the restoration of normal lysosomal size, and the treatment of lysosomal storage disorders (LSDs) are provided. (nih.gov)
  • The inventors have discovered that tocopherol and tocopheryl quinone derivatives with side chain modifications (such as terminal tri-halogenated methyl groups) exhibit improved pharmacokinetics, modulation of mitochondrial potential and restoration of some LSDs phenotypes. (nih.gov)
  • By carrying out the reaction under gold catalysis and utilizing alkynyl benzyl alcohols as electron-rich reaction partners, this approach provides a useful strategy for settling the challenges in oxa-[4+2] cyclization of para -quinone methide derivatives. (figshare.com)
  • Pharma-Nord Bio-Quinone is manufactured under Danish pharmaceutical control, and is available in capsules containing 30mg and 100mg of coenzyme Q10 respectively. (johnbellcroyden.co.uk)
  • Q10 Green Bio-Quinone 100mg. (dulwichhealth.co.uk)
  • Story: Chip Zdarsky Art: Joe Quinones Cover: Joe Quinones Publisher: Marvel Publication Date: June 8th, 2016 Price: $3.99 "HOME" STARTS NOW! (all-comic.com)
  • John Quinones with family celebrates daughter Andrea's birthday on 8 May 2016. (wikinetworth.com)
  • Howard the Duck returns, courtesy of the sensational creative team of Chip Zdarsky and Joe Quinones - they're the duckiest! (ecampus.com)
  • Howard The Duck #1 Marvel Comics Writer Chip Zdarsky, Artist Joe Quinones, Colorist Rico Renzi, Letterer Travis Lanham Doing a new Howard the Duck without the original creator Steve Gerber is always going to be a tough road to travel. (popculturemaven.com)
  • Palladium-Catalyzed Asymmetric 1,4-Addition of Diarylphosphines to Quinone Monoketals[J]. Chinese Journal of Organic Chemistry, 2020, 40(1): 61-68. (sioc-journal.cn)
  • These results indicate that MDMA is oxidized by cytochrome P-450 to the catechol and the catecholamine oxidized by superoxide to a quinone to which GSH or other thiol functions add. (erowid.org)
  • The polycyclic quinones occur in some bacteria, fungi, and parts of higher plants. (britannica.com)
  • Coenzyme quinones occur in several chemical forms, with coenzyme Q10 being the only form found in human tissues. (johnbellcroyden.co.uk)
  • Each capsule of Pharma-Nord Bio-Quinone Q10 contains coenzyme Q10 in a highly absorbable form, using a patented soybean oil based delivery system. (johnbellcroyden.co.uk)
  • Ubiquinone CoQ10 is Pharma Nord's Bio-Quinone Q10 Vegan capsule, containing coenzyme Q10 in the form of ubiquinone in its natural identical form. (dulwichhealth.co.uk)
  • With a great reporter's narrative skill and the storytelling ability of a novelist, acclaimed journalist Sam Quinones weaves together two classic tales of capitalism run amok whose unintentional collision has been catastrophic. (audible.co.jp)
  • In 2015, award-winning author and journalist Sam Quinones took the world by storm with his heavily lauded book Dreamland: The True Tale of America's Opioid Epidemic , an investigative work that helped awaken the nation to the devastation wreaked by OxyContin. (drugfree.org)
  • Sam Quinones is a journalist, storyteller, former LA Times reporter and author of three critically acclaimed books of non-fiction. (constantcontact.com)
  • Los Angeles Times reporter Sam Quinones' new book on Mexican immigration, Antonio's Gun and Delfino's Dream, has been lauded in the San Francisco Chronicle, Los Angeles Times, Publishers Weekly, and Library Journal and Quinones has been interviewed on All Things Considered, CSPAN, and News Hour with Jim Lehrer . (blogspot.com)
  • A former Los Angeles Times reporter, Quinones chronicles the rise of black-tar heroin from Mexico in his 2015 book Dreamland . (nih.gov)
  • Before, his job as reporter Quinones started his journalism career as a general assignment correspondent with ABC News and later anchored for the show. (wikinetworth.com)
  • "Metabolism of methylenedioxymethamphetamine: formation of dihydroxymethamphetamine and a quinone identified as its glutathione adduct" J Pharmacol Exp Ther . (erowid.org)
  • An overview of Genetic Toxicology Bacterial Mutagenicity study conclusions related to p-Quinone (106-51-4). (nih.gov)
  • Genetic Toxicity Evaluation of p-Quinone in Salmonella/E.coli Mutagenicity Test or Ames Test. (nih.gov)
  • NIEHS, NIH grant application R01 ES007943-10, Prevention of Quinone Toxicity and Mutagenicity (funded). (nih.gov)
  • NIEHS, NIH grant application R01 ES021483-01, Quinone Oxidoreductases and Mammary Toxicity/Carcinogenicity (unfunded). (nih.gov)
  • Quinone oxidoreductases in protection against myelogenous hyperplasia and benzene toxicity. (nih.gov)
  • Dr. Chiang introduced and welcomed two new Council members Ms. Janni Lehrer-Stein and Dr. Victor Perez-Quinones. (nih.gov)
  • Dr. Perez-Quinones is a Professor of Ophthalmology at Duke University with expertise in ocular inflammation, graft vs host disease, and clinical trials. (nih.gov)
  • The transient effect for the collisional quenching caused the upward deviation of the plots of the inversed fluorescence intensities of the porphyrins vs the quinone concentrations. (elsevier.com)
  • abstract = "The fluorescent states of tetratolylporphyrin and its zinc complex in acetone were quenched by various kinds of quinones. (elsevier.com)
  • Quinones, Louis, "Determining Principal Stress Orientations and Magnitudes in the Fort Worth Basin, Texas" (2018). (smu.edu)
  • Nicknamed the "Methuselah" quinone - after the longest-lived Biblical figure - this molecule could usefully store and release energy many tens of thousands of times over multi-year periods. (internationales-verkehrswesen.de)
  • The Methuselah molecule is a modified quinone, an abundant, naturally occurring molecule integral to biological processes like photosynthesis and cellular respiration. (internationales-verkehrswesen.de)
  • Besides their chemical properties, quinones have demonstrated interesting biological activities, including activity against respiratory viruses. (nih.gov)
  • As the crisis was unfolding, author Sam Quinones was living in Mexico and has since interviewed many affected on both sides of the border, from people who are addicted to families who lost loved ones, from imprisoned drug traffickers to prosecutors. (nih.gov)
  • Kudos to Mrs. Quinones at Del Valle Elementary School! (yisd.net)
  • This review summarizes the activity against respiratory viruses and their molecular targets by the different types of quinones (both natural and synthetic). (nih.gov)
  • Quinones has written two books on the rise of synthetic opioids, Dreamland and The Least of Us. (nih.gov)
  • No inhalation toxicity data are available on which to base an IDLH for quinone. (cdc.gov)
  • Therefore, the revised IDLH for quinone is 100 mg/m 3 based on acute oral toxicity data in animals [Woodward et al. (cdc.gov)
  • Collaborating with theoretical chemistry Professor Alán Aspuru-Guzik, their research team characterized the degradation process of previous quinone molecules in flow batteries and made modifications to increase the calendar life. (internationales-verkehrswesen.de)
  • That heroin got here every year cheaper and every year more potent," said Quinones. (nih.gov)
  • They soon realized he's created this enormously potent profit center they didn't even know existed," Quinones said. (nih.gov)
  • From Business: Dr. Eugenio Quinones is a Plant City, Florida area physician. (yellowpages.com)