Hydrocarbon rings which contain two ketone moieties in any position. They can be substituted in any position except at the ketone groups.
A flavoprotein that reversibly catalyzes the oxidation of NADH or NADPH by various quinones and oxidation-reduction dyes. The enzyme is inhibited by dicoumarol, capsaicin, and caffeine.
NAD(P)H:(quinone acceptor) oxidoreductases. A family that includes three enzymes which are distinguished by their sensitivity to various inhibitors. EC (NAD(P)H DEHYDROGENASE (QUINONE);) is a flavoprotein which reduces various quinones in the presence of NADH or NADPH and is inhibited by dicoumarol. EC (NADH dehydrogenase (quinone)) requires NADH, is inhibited by AMP and 2,4-dinitrophenol but not by dicoumarol or folic acid derivatives. EC (NADPH dehydrogenase (quinone)) requires NADPH and is inhibited by dicoumarol and folic acid derivatives but not by 2,4-dinitrophenol.
A pyrrolo-quinoline having two adjacent keto-groups at the 4 and 5 positions and three acidic carboxyl groups. It is a coenzyme of some DEHYDROGENASES.
Benzene rings which contain two ketone moieties in any position. They can be substituted in any position except at the ketone groups.
An oral anticoagulant that interferes with the metabolism of vitamin K. It is also used in biochemical experiments as an inhibitor of reductases.
INDOLES which have two keto groups forming QUINONES like structures of the indole aromatic ring.
Naphthalene rings which contain two ketone moieties in any position. They can be substituted in any position except at the ketone groups.
A lipid-soluble benzoquinone which is involved in ELECTRON TRANSPORT in mitochondrial preparations. The compound occurs in the majority of aerobic organisms, from bacteria to higher plants and animals.
A chemical reaction in which an electron is transferred from one molecule to another. The electron-donating molecule is the reducing agent or reductant; the electron-accepting molecule is the oxidizing agent or oxidant. Reducing and oxidizing agents function as conjugate reductant-oxidant pairs or redox pairs (Lehninger, Principles of Biochemistry, 1982, p471).
Constituent of 30S subunit prokaryotic ribosomes containing 1600 nucleotides and 21 proteins. 16S rRNA is involved in initiation of polypeptide synthesis.
The relative amounts of the PURINES and PYRIMIDINES in a nucleic acid.
DNA sequences encoding RIBOSOMAL RNA and the segments of DNA separating the individual ribosomal RNA genes, referred to as RIBOSOMAL SPACER DNA.
The process by which ELECTRONS are transported from a reduced substrate to molecular OXYGEN. (From Bennington, Saunders Dictionary and Encyclopedia of Laboratory Medicine and Technology, 1984, p270)
Saturated azacyclopropane compounds. They include compounds with substitutions on CARBON or NITROGEN atoms.
The relationships of groups of organisms as reflected by their genetic makeup.
Organic, monobasic acids derived from hydrocarbons by the equivalent of oxidation of a methyl group to an alcohol, aldehyde, and then acid. Fatty acids are saturated and unsaturated (FATTY ACIDS, UNSATURATED). (Grant & Hackh's Chemical Dictionary, 5th ed)
A lipid cofactor that is required for normal blood clotting. Several forms of vitamin K have been identified: VITAMIN K 1 (phytomenadione) derived from plants, VITAMIN K 2 (menaquinone) from bacteria, and synthetic naphthoquinone provitamins, VITAMIN K 3 (menadione). Vitamin K 3 provitamins, after being alkylated in vivo, exhibit the antifibrinolytic activity of vitamin K. Green leafy vegetables, liver, cheese, butter, and egg yolk are good sources of vitamin K.
Procedures for identifying types and strains of bacteria. The most frequently employed typing systems are BACTERIOPHAGE TYPING and SEROTYPING as well as bacteriocin typing and biotyping.
Deoxyribonucleic acid that makes up the genetic material of bacteria.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Genes, found in both prokaryotes and eukaryotes, which are transcribed to produce the RNA which is incorporated into RIBOSOMES. Prokaryotic rRNA genes are usually found in OPERONS dispersed throughout the GENOME, whereas eukaryotic rRNA genes are clustered, multicistronic transcriptional units.
Polyunsaturated side-chain quinone derivative which is an important link in the electron transport chain of green plants during the photosynthetic conversion of light energy by photophosphorylation into the potential energy of chemical bonds.
Protein complexes that take part in the process of PHOTOSYNTHESIS. They are located within the THYLAKOID MEMBRANES of plant CHLOROPLASTS and a variety of structures in more primitive organisms. There are two major complexes involved in the photosynthetic process called PHOTOSYSTEM I and PHOTOSYSTEM II.
A flavoprotein oxidase complex that contains iron-sulfur centers. It catalyzes the oxidation of SUCCINATE to fumarate and couples the reaction to the reduction of UBIQUINONE to ubiquinol.
The 8-hydroxy derivatives inhibit various enzymes and their halogenated derivatives, though neurotoxic, are used as topical anti-infective agents, among other uses.
Spherical phototrophic bacteria found in mud and stagnant water exposed to light.
A group of substances similar to VITAMIN K 1 which contains a ring of 2-methyl-1,4-naphthoquinione and an isoprenoid side chain of varying number of isoprene units. In vitamin K 2, each isoprene unit contains a double bond. They are produced by bacteria including the normal intestinal flora.
D-Glucose:1-oxidoreductases. Catalyzes the oxidation of D-glucose to D-glucono-gamma-lactone and reduced acceptor. Any acceptor except molecular oxygen is permitted. Includes EC; EC; EC and EC
Small molecules that are required for the catalytic function of ENZYMES. Many VITAMINS are coenzymes.
A beta-hydroxylated derivative of phenylalanine. The D-form of dihydroxyphenylalanine has less physiologic activity than the L-form and is commonly used experimentally to determine whether the pharmacological effects of LEVODOPA are stereospecific.
The class of all enzymes catalyzing oxidoreduction reactions. The substrate that is oxidized is regarded as a hydrogen donor. The systematic name is based on donor:acceptor oxidoreductase. The recommended name will be dehydrogenase, wherever this is possible; as an alternative, reductase can be used. Oxidase is only used in cases where O2 is the acceptor. (Enzyme Nomenclature, 1992, p9)
A group of enzymes including those oxidizing primary monoamines, diamines, and histamine. They are copper proteins, and, as their action depends on a carbonyl group, they are sensitive to inhibition by semicarbazide.
2- or 4-Hydroxyestrogens. Substances that are physiologically active in mammals, especially in the control of gonadotropin secretion. Physiological activity can be ascribed to either an estrogenic action or interaction with the catecholaminergic system.
A multistage process that includes cloning, physical mapping, subcloning, determination of the DNA SEQUENCE, and information analysis.
The presence of bacteria, viruses, and fungi in the soil. This term is not restricted to pathogenic organisms.
A synthetic naphthoquinone without the isoprenoid side chain and biological activity, but can be converted to active vitamin K2, menaquinone, after alkylation in vivo.
Life or metabolic reactions occurring in an environment containing oxygen.
A technique applicable to the wide variety of substances which exhibit paramagnetism because of the magnetic moments of unpaired electrons. The spectra are useful for detection and identification, for determination of electron structure, for study of interactions between molecules, and for measurement of nuclear spins and moments. (From McGraw-Hill Encyclopedia of Science and Technology, 7th edition) Electron nuclear double resonance (ENDOR) spectroscopy is a variant of the technique which can give enhanced resolution. Electron spin resonance analysis can now be used in vivo, including imaging applications such as MAGNETIC RESONANCE IMAGING.
A quinone fungicide used for treatment of seeds and foliage.
A multisubunit enzyme complex that contains CYTOCHROME B GROUP; CYTOCHROME C1; and iron-sulfur centers. It catalyzes the oxidation of ubiquinol to UBIQUINONE, and transfers the electrons to CYTOCHROME C. In MITOCHONDRIA the redox reaction is coupled to the transport of PROTONS across the inner mitochondrial membrane.
Stable elementary particles having the smallest known negative charge, present in all elements; also called negatrons. Positively charged electrons are called positrons. The numbers, energies and arrangement of electrons around atomic nuclei determine the chemical identities of elements. Beams of electrons are called CATHODE RAYS.
At low concentrations, this compound inhibits reduction of conventional hydrophilic electron acceptors, probably acting as a plastoquinone antagonist. At higher concentrations, it acts as an electron acceptor, intercepting electrons either before or at the site of its inhibitory activity.
The location of the atoms, groups or ions relative to one another in a molecule, as well as the number, type and location of covalent bonds.
The rate dynamics in chemical or physical systems.
A mass of organic or inorganic solid fragmented material, or the solid fragment itself, that comes from the weathering of rock and is carried by, suspended in, or dropped by air, water, or ice. It refers also to a mass that is accumulated by any other natural agent and that forms in layers on the earth's surface, such as sand, gravel, silt, mud, fill, or loess. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed, p1689)
A group of 1,2-benzenediols that contain the general formula R-C6H5O2.
A flavoprotein containing oxidoreductase that catalyzes the dehydrogenation of SUCCINATE to fumarate. In most eukaryotic organisms this enzyme is a component of mitochondrial electron transport complex II.
A group of derivatives of naphthyridine carboxylic acid, quinoline carboxylic acid, or NALIDIXIC ACID.
A flavoprotein and iron sulfur-containing oxidoreductase complex that catalyzes the conversion of UBIQUINONE to ubiquinol. In MITOCHONDRIA the complex also couples its reaction to the transport of PROTONS across the internal mitochondrial membrane. The NADH DEHYDROGENASE component of the complex can be isolated and is listed as EC
A family of phylloquinones that contains a ring of 2-methyl-1,4-naphthoquinone and an isoprenoid side chain. Members of this group of vitamin K 1 have only one double bond on the proximal isoprene unit. Rich sources of vitamin K 1 include green plants, algae, and photosynthetic bacteria. Vitamin K1 has antihemorrhagic and prothrombogenic activity.
A basic-leucine zipper transcription factor that was originally described as a transcriptional regulator controlling expression of the BETA-GLOBIN gene. It may regulate the expression of a wide variety of genes that play a role in protecting cells from oxidative damage.
Pigment obtained by the oxidation of epinephrine.
A coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. It is found widely in nature and is involved in numerous enzymatic reactions in which it serves as an electron carrier by being alternately oxidized (NAD+) and reduced (NADH). (Dorland, 27th ed)
Any normal or abnormal coloring matter in PLANTS; ANIMALS or micro-organisms.
A group of oxidoreductases that act on NADH or NADPH. In general, enzymes using NADH or NADPH to reduce a substrate are classified according to the reverse reaction, in which NAD+ or NADP+ is formally regarded as an acceptor. This subclass includes only those enzymes in which some other redox carrier is the acceptor. (Enzyme Nomenclature, 1992, p100) EC 1.6.
Complex cytotoxic antibiotic obtained from Streptomyces flocculus or S. rufochronmogenus. It is used in advanced carcinoma and causes leukopenia.
Mixture of 2- and 3-tert-butyl-4-methoxyphenols that is used as an antioxidant in foods, cosmetics, and pharmaceuticals.
A genus of gram-negative, anaerobic, rod-shaped bacteria isolated from the bovine RUMEN, the human gingival sulcus, and dental PULPITIS infections.
A phylum of bacteria comprised of three classes: Bacteroides, Flavobacteria, and Sphingobacteria.
A family of bacteria which produce endospores. They are mostly saprophytes from soil, but a few are insect or animal parasites or pathogens.
An enzyme of the oxidoreductase class that catalyzes the reaction between L-tyrosine, L-dopa, and oxygen to yield L-dopa, dopaquinone, and water. It is a copper protein that acts also on catechols, catalyzing some of the same reactions as CATECHOL OXIDASE. EC
Nicotinamide adenine dinucleotide phosphate. A coenzyme composed of ribosylnicotinamide 5'-phosphate (NMN) coupled by pyrophosphate linkage to the 5'-phosphate adenosine 2',5'-bisphosphate. It serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH). (Dorland, 27th ed)
A class in the phylum PROTEOBACTERIA comprised mostly of two major phenotypes: purple non-sulfur bacteria and aerobic bacteriochlorophyll-containing bacteria.
A family of bracket fungi, order POLYPORALES, living in decaying plant matter and timber.
The salinated water of OCEANS AND SEAS that provides habitat for marine organisms.
A flavoprotein that reversibly oxidizes NADPH to NADP and a reduced acceptor. EC
Compounds based on ANTHRACENES which contain two KETONES in any position. Substitutions can be in any position except on the ketone groups.
A group of crystallins that have been found in the lens (LENS, CRYSTALLINE) of certain species of VERTEBRATES including GUINEA PIGS; CAMELS; and LLAMAS. They are inactivated forms of NAD(P)H DEHYDROGENASE (QUINONE).
A group of compounds that are derivatives of methoxybenzene and contain the general formula R-C7H7O.
The products of chemical reactions that result in the addition of extraneous chemical groups to DNA.
A coenzyme for a number of oxidative enzymes including NADH DEHYDROGENASE. It is the principal form in which RIBOFLAVIN is found in cells and tissues.
An enzyme of the oxidoreductase class that catalyzes the reaction between catechol and oxygen to yield benzoquinone and water. It is a complex of copper-containing proteins that acts also on a variety of substituted catechols. EC
Enzymes catalyzing the dehydrogenation of secondary amines, introducing a C=N double bond as the primary reaction. In some cases this is later hydrolyzed.
The chemical alteration of an exogenous substance by or in a biological system. The alteration may inactivate the compound or it may result in the production of an active metabolite of an inactive parent compound. The alterations may be divided into METABOLIC DETOXICATION, PHASE I and METABOLIC DETOXICATION, PHASE II.
Reduction of pharmacologic activity or toxicity of a drug or other foreign substance by a living system, usually by enzymatic action. It includes those metabolic transformations that make the substance more soluble for faster renal excretion.
The normality of a solution with respect to HYDROGEN ions; H+. It is related to acidity measurements in most cases by pH = log 1/2[1/(H+)], where (H+) is the hydrogen ion concentration in gram equivalents per liter of solution. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)
A ubiquitous sodium salt that is commonly used to season food.
An estrogenic steroid produced by HORSES. It has a total of five double bonds in the A- and B-ring. High concentration of equilenin is found in the URINE of pregnant mares.
A family of bacteria in the order Sphingobacteriales, class Sphingobacteria. They are gram-negative rods, mostly saprophytic in terrestrial and aquatic habitats.
A genus of gram-negative bacteria widely distributed in fresh water as well as marine and hypersaline habitats.
Ribonucleic acid in bacteria having regulatory and catalytic roles as well as involvement in protein synthesis.
A class of chemicals that contain an anthracene ring with a naphthalene ring attached to it.
Theoretical representations that simulate the behavior or activity of chemical processes or phenomena; includes the use of mathematical equations, computers, and other electronic equipment.
The parts of a macromolecule that directly participate in its specific combination with another molecule.
Widely used technique which exploits the ability of complementary sequences in single-stranded DNAs or RNAs to pair with each other to form a double helix. Hybridization can take place between two complimentary DNA sequences, between a single-stranded DNA and a complementary RNA, or between two RNA sequences. The technique is used to detect and isolate specific sequences, measure homology, or define other characteristics of one or both strands. (Kendrew, Encyclopedia of Molecular Biology, 1994, p503)
A condensation product of riboflavin and adenosine diphosphate. The coenzyme of various aerobic dehydrogenases, e.g., D-amino acid oxidase and L-amino acid oxidase. (Lehninger, Principles of Biochemistry, 1982, p972)
Determination of the spectra of ultraviolet absorption by specific molecules in gases or liquids, for example Cl2, SO2, NO2, CS2, ozone, mercury vapor, and various unsaturated compounds. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
A flavoprotein and iron sulfur-containing oxidoreductase that catalyzes the oxidation of NADH to NAD. In eukaryotes the enzyme can be found as a component of mitochondrial electron transport complex I. Under experimental conditions the enzyme can use CYTOCHROME C GROUP as the reducing cofactor. The enzyme was formerly listed as EC
Former kingdom, located on Korea Peninsula between Sea of Japan and Yellow Sea on east coast of Asia. In 1948, the kingdom ceased and two independent countries were formed, divided by the 38th parallel.
Proteins found in any species of bacterium.
The art or process of comparing photometrically the relative intensities of the light in different parts of the spectrum.
An order of gram-positive, primarily aerobic BACTERIA that tend to form branching filaments.
A naturally occurring phenolic acid which is a carcinogenic inhibitor. It has also been shown to prevent paraquat-induced oxidative stress in rats. (From J Chromatogr A 1996;741(2):223-31; Biosci Biotechnol Biochem 1996;60(5):765-68).
A subclass of enzymes which includes all dehydrogenases acting on primary and secondary alcohols as well as hemiacetals. They are further classified according to the acceptor which can be NAD+ or NADP+ (subclass 1.1.1), cytochrome (1.1.2), oxygen (1.1.3), quinone (1.1.5), or another acceptor (1.1.99).
Liquid chromatographic techniques which feature high inlet pressures, high sensitivity, and high speed.
A potent mutagen and carcinogen. It is a public health concern because of its possible effects on industrial workers, as an environmental pollutant, an as a component of tobacco smoke.
The restriction of a characteristic behavior, anatomical structure or physical system, such as immune response; metabolic response, or gene or gene variant to the members of one species. It refers to that property which differentiates one species from another but it is also used for phylogenetic levels higher or lower than the species.
Naturally occurring or synthetic substances that inhibit or retard the oxidation of a substance to which it is added. They counteract the harmful and damaging effects of oxidation in animal tissues.
A transferase that catalyzes the addition of aliphatic, aromatic, or heterocyclic FREE RADICALS as well as EPOXIDES and arene oxides to GLUTATHIONE. Addition takes place at the SULFUR. It also catalyzes the reduction of polyol nitrate by glutathione to polyol and nitrite.
A tripeptide with many roles in cells. It conjugates to drugs to make them more soluble for excretion, is a cofactor for some enzymes, is involved in protein disulfide bond rearrangement and reduces peroxides.
Models used experimentally or theoretically to study molecular shape, electronic properties, or interactions; includes analogous molecules, computer-generated graphics, and mechanical structures.
The measurement of the amplitude of the components of a complex waveform throughout the frequency range of the waveform. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)
An increase in the rate of synthesis of an enzyme due to the presence of an inducer which acts to derepress the gene responsible for enzyme synthesis.
Stable elementary particles having the smallest known positive charge, found in the nuclei of all elements. The proton mass is less than that of a neutron. A proton is the nucleus of the light hydrogen atom, i.e., the hydrogen ion.
A species of gram-negative, facultatively anaerobic, rod-shaped bacteria (GRAM-NEGATIVE FACULTATIVELY ANAEROBIC RODS) commonly found in the lower part of the intestine of warm-blooded animals. It is usually nonpathogenic, but some strains are known to produce DIARRHEA and pyogenic infections. Pathogenic strains (virotypes) are classified by their specific pathogenic mechanisms such as toxins (ENTEROTOXIGENIC ESCHERICHIA COLI), etc.
A group of the proteobacteria comprised of facultatively anaerobic and fermentative gram-negative bacteria.
The Borage plant family is in the class Magnoliopsida, subclass Asteridae, order Lamiales. It is characterized by hairy foliage, usually alternate and simple; flowers are funnel-shaped or tubular. Some of the species contain PYRROLIZIDINE ALKALOIDS.
Reversibly catalyze the oxidation of a hydroxyl group of carbohydrates to form a keto sugar, aldehyde or lactone. Any acceptor except molecular oxygen is permitted. Includes EC 1.1.1.; EC 1.1.2.; and 1.1.99.
Derivatives of the dimethylisoalloxazine (7,8-dimethylbenzo[g]pteridine-2,4(3H,10H)-dione) skeleton. Flavin derivatives serve an electron transfer function as ENZYME COFACTORS in FLAVOPROTEINS.
A group of proteins possessing only the iron-sulfur complex as the prosthetic group. These proteins participate in all major pathways of electron transport: photosynthesis, respiration, hydroxylation and bacterial hydrogen and nitrogen fixation.
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
Highly reactive molecules with an unsatisfied electron valence pair. Free radicals are produced in both normal and pathological processes. They are proven or suspected agents of tissue damage in a wide variety of circumstances including radiation, damage from environment chemicals, and aging. Natural and pharmacological prevention of free radical damage is being actively investigated.
Pyrrole containing pigments found in photosynthetic bacteria.
Cytochromes (electron-transporting proteins) with protoheme (HEME B) as the prosthetic group.
The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment.
Refuse liquid or waste matter carried off by sewers.
A large multisubunit protein complex found in the THYLAKOID MEMBRANE. It uses light energy derived from LIGHT-HARVESTING PROTEIN COMPLEXES to catalyze the splitting of WATER into DIOXYGEN and of reducing equivalents of HYDROGEN.
The complete absence, or (loosely) the paucity, of gaseous or dissolved elemental oxygen in a given place or environment. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)
Organic compounds with the general formula R-NCS.
A family of gram-negative bacteria, in the order Xanthomonadales, pathogenic to plants.
Porphyrin derivatives containing magnesium that act to convert light energy in photosynthetic organisms.
Non-pathogenic ovoid to rod-shaped bacteria that are widely distributed and found in fresh water as well as marine and hypersaline habitats.
The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide using energy obtained from light rather than from the oxidation of chemical compounds. Photosynthesis comprises two separate processes: the light reactions and the dark reactions. In higher plants; GREEN ALGAE; and CYANOBACTERIA; NADPH and ATP formed by the light reactions drive the dark reactions which result in the fixation of carbon dioxide. (from Oxford Dictionary of Biochemistry and Molecular Biology, 2001)
An experimental lymphocytic leukemia of mice.
Complexes containing CHLOROPHYLL and other photosensitive molecules. They serve to capture energy in the form of PHOTONS and are generally found as components of the PHOTOSYSTEM I PROTEIN COMPLEX or the PHOTOSYSTEM II PROTEIN COMPLEX.
A flavoprotein containing oxidoreductase that catalyzes the reduction of lipoamide by NADH to yield dihydrolipoamide and NAD+. The enzyme is a component of several MULTIENZYME COMPLEXES.
The property of objects that determines the direction of heat flow when they are placed in direct thermal contact. The temperature is the energy of microscopic motions (vibrational and translational) of the particles of atoms.
A protein complex that includes CYTOCHROME B6 and CYTOCHROME F. It is found in the THYLAKOID MEMBRANE and plays an important role in process of PHOTOSYNTHESIS by transferring electrons from PLASTOQUINONE to PLASTOCYANIN or CYTOCHROME C6. The transfer of electrons is coupled to the transport of PROTONS across the membrane.
The study of chemical changes resulting from electrical action and electrical activity resulting from chemical changes.
A genus of asporogenous bacteria isolated from soil that displays a distinctive rod-coccus growth cycle.
The presence of bacteria, viruses, and fungi in water. This term is not restricted to pathogenic organisms.
Diazo derivatives of aniline, used as a reagent for sugars, ketones, and aldehydes. (Dorland, 28th ed)
A large multisubunit protein complex that is found in the THYLAKOID MEMBRANE. It uses light energy derived from LIGHT-HARVESTING PROTEIN COMPLEXES to drive electron transfer reactions that result in either the reduction of NADP to NADPH or the transport of PROTONS across the membrane.
The relationship between the chemical structure of a compound and its biological or pharmacological activity. Compounds are often classed together because they have structural characteristics in common including shape, size, stereochemical arrangement, and distribution of functional groups.
An element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on earth and essential for respiration.
Hemeproteins whose characteristic mode of action involves transfer of reducing equivalents which are associated with a reversible change in oxidation state of the prosthetic group. Formally, this redox change involves a single-electron, reversible equilibrium between the Fe(II) and Fe(III) states of the central iron atom (From Enzyme Nomenclature, 1992, p539). The various cytochrome subclasses are organized by the type of HEME and by the wavelength range of their reduced alpha-absorption bands.
Systems of enzymes which function sequentially by catalyzing consecutive reactions linked by common metabolic intermediates. They may involve simply a transfer of water molecules or hydrogen atoms and may be associated with large supramolecular structures such as MITOCHONDRIA or RIBOSOMES.
The study of crystal structure using X-RAY DIFFRACTION techniques. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
An antineoplastic antibiotic produced by Streptomyces caespitosus. It is one of the bi- or tri-functional ALKYLATING AGENTS causing cross-linking of DNA and inhibition of DNA synthesis.
A family of gram-negative, asporogenous rods or ovoid cells, aerobic or facultative anaerobic chemoorganotrophs. They are commonly isolated from SOIL, activated sludge, or marine environments.

Assaying potential carcinogens with Drosophila. (1/2088)

Drosophila offers many advantages for the detection of mutagenic activity of carcinogenic agents. It provides the quickest assay system for detecting mutations in animals today. Its generation time is short, and Drosophila is cheap and easy to breed in large numbers. The simple genetic testing methods give unequivocal answers about the whole spectrum of relevant genetic damage. A comparison of the detection capacity of assays sampling different kinds of genetic damage revealed that various substances are highly effective in inducing mutations but do not produce chromosome breakage effects at all, or only at much higher concentrations than those required for mutation induction. Of the different assay systems available, the classical sex-linked recessive lethal test deserves priority, in view of its superior capacity to detect mutagens. Of practical importance is also its high sensitivity, because a large number of loci in one fifth of the genome is tested for newly induced forward mutations, including small deletions. The recent findings that Drosophila is capable of carrying out the same metabolic activation reactions as the mammalian liver makes the organism eminently suitable for verifying results obtained in prescreening with fast microbial assay systems. An additional advantage in this respect is the capacity of Drosophila for detecting short-lived activation products, because intracellular metabolic activation appears to occur within the spermatids and spermatocytes.  (+info)

p50(cdc37) acting in concert with Hsp90 is required for Raf-1 function. (2/2088)

Genetic screens in Drosophila have identified p50(cdc37) to be an essential component of the sevenless receptor/mitogen-activated kinase protein (MAPK) signaling pathway, but neither the function nor the target of p50(cdc37) in this pathway has been defined. In this study, we examined the role of p50(cdc37) and its Hsp90 chaperone partner in Raf/Mek/MAPK signaling biochemically. We found that coexpression of wild-type p50(cdc37) with Raf-1 resulted in robust and dose-dependent activation of Raf-1 in Sf9 cells. In addition, p50(cdc37) greatly potentiated v-Src-mediated Raf-1 activation. Moreover, we found that p50(cdc37) is the primary determinant of Hsp90 recruitment to Raf-1. Overexpression of a p50(cdc37) mutant which is unable to recruit Hsp90 into the Raf-1 complex inhibited Raf-1 and MAPK activation by growth factors. Similarly, pretreatment with geldanamycin (GA), an Hsp90-specific inhibitor, prevented both the association of Raf-1 with the p50(cdc37)-Hsp90 heterodimer and Raf-1 kinase activation by serum. Activation of Raf-1 via baculovirus coexpression with oncogenic Src or Ras in Sf9 cells was also strongly inhibited by dominant negative p50(cdc37) or by GA. Thus, formation of a ternary Raf-1-p50(cdc37)-Hsp90 complex is crucial for Raf-1 activity and MAPK pathway signaling. These results provide the first biochemical evidence for the requirement of the p50(cdc37)-Hsp90 complex in protein kinase regulation and for Raf-1 function in particular.  (+info)

UV irradiation of polycyclic aromatic hydrocarbons in ices: production of alcohols, quinones, and ethers. (3/2088)

Polycyclic aromatic hydrocarbons (PAHs) in water ice were exposed to ultraviolet (UV) radiation under astrophysical conditions, and the products were analyzed by infrared spectroscopy and mass spectrometry. Peripheral carbon atoms were oxidized, producing aromatic alcohols, ketones, and ethers, and reduced, producing partially hydrogenated aromatic hydrocarbons, molecules that account for the interstellar 3.4-micrometer emission feature. These classes of compounds are all present in carbonaceous meteorites. Hydrogen and deuterium atoms exchange readily between the PAHs and the ice, which may explain the deuterium enrichments found in certain meteoritic molecules. This work has important implications for extraterrestrial organics in biogenesis.  (+info)

Salmonella typhimurium and lipopolysaccharide stimulate extracellularly regulated kinase activation in macrophages by a mechanism involving phosphatidylinositol 3-kinase and phospholipase D as novel intermediates. (4/2088)

Activation of the extracellularly regulated kinase (ERK) pathway is part of the early biochemical events that follow lipopolysaccharide (LPS) treatment of macrophages or their infection by virulent and attenuated Salmonella strains. Phagocytosis as well as the secretion of invasion-associated proteins is dispensable for ERK activation by the pathogen. Furthermore, the pathways used by Salmonella and LPS to stimulate ERK are identical, suggesting that kinase activation might be solely mediated by LPS. Both stimuli activate ERK by a mechanism involving herbimycin-dependent tyrosine kinase(s) and phosphatidylinositol 3-kinase. Phospholipase D activation and stimulation of protein kinase C appear to be intermediates in this novel pathway of MEK/ERK activation.  (+info)

Involvement of tyrosine phosphorylation in HMG-CoA reductase inhibitor-induced cell death in L6 myoblasts. (5/2088)

Our previous studies have shown that the HMG-CoA reductase (HCR) inhibitor (HCRI), simvastatin, causes myopathy in rabbits and kills L6 myoblasts. The present study was designed to elucidate the molecular mechanism of HCRI-induced cell death. We have demonstrated that simvastatin induces the tyrosine phosphorylation of several cellular proteins within 10 min. These phosphorylations were followed by apoptosis, as evidenced by the occurrence of internucleosomal DNA fragmentation and by morphological changes detected with Nomarski optics. Simvastatin-induced cell death was prevented by tyrosine kinase inhibitors. The MTT assay revealed that the addition of mevalonic acid into the culture medium partially inhibited simvastatin-induced cell death. Thus, these results suggested that protein tyrosine phosphorylation might play an important role in the intracellular signal transduction pathway mediating the HCRI-induced death of myoblasts.  (+info)

Dose-specific production of chlorinated quinone and semiquinone adducts in rodent livers following administration of pentachlorophenol. (6/2088)

Production of chlorinated quinoid metabolites was investigated in the livers of Sprague-Dawley rats and B6C3F1 mice following single oral administration of pentachlorophenol (PCP) (0-40 mg/kg body weight) and in male Fischer 344 rats, following chronic ingestion of PCP at 1,000 ppm in the diet for 6 months (equivalent to 60 mg PCP/kg body weight/day). Analyses of the rates of adduction in the livers of Sprague-Dawley rats and B6C3F1 mice suggested that the production of tetrachloro-1,2-benzosemiquinone (Cl4-1,2-SQ) adducts was proportionally greater at low doses of PCP (less than 4-10 mg/kg body weight) and was 40-fold greater in rats than in mice. Production of tetrachloro-1,4-benzoquinone (Cl4-1,4-BQ) adducts, on the other hand, was proportionally greater at high doses of PCP [greater than 60-230 mg/kg body weight] and was 2- to 11-fold greater in mice than in rats over the entire range of dosages. A mathematical model employed these data to predict the rates of daily adduct production and steady state levels of PCP-derived quinone and semiquinone adducts in rats and mice. To evaluate predictions of the model, levels of PCP-derived adducts at steady state were investigated in the livers of male Fischer 344 rats chronically ingesting 60 mg PCP/kg body weight/day. Levels of total Cl4-1,4-BQ-derived adducts in liver cytosolic proteins (Cp) (22.0 nmol/g) and in liver nuclear proteins (Np) (3.07 nmol/g) were comparable to those of model predictions (15.0 and 3.02 nmol/g for Cp and Np, respectively). Overall, these results suggest that species differences in the metabolism of PCP to semiquinones and quinones were, in part, responsible for the production of liver tumors in mice but not rats in chronic bioassays.  (+info)

Stimulation of ultraviolet-induced apoptosis of human fibroblast UVr-1 cells by tyrosine kinase inhibitors. (7/2088)

Damnacanthal is an anthraquinone compound isolated from the root of Morinda citrifolia and was reported to have a potent inhibitory activity towards tyrosine kinases such as Lck, Src, Lyn and EGF receptor. In the present study, we have examined the effects of damnacanthal on ultraviolet ray-induced apoptosis in ultraviolet-resistant human UVr-1 cells. When the cells were treated with damnacanthal prior to ultraviolet irradiation, DNA fragmentation was more pronounced as compared to the case of ultraviolet irradiation alone. The other tyrosine kinase inhibitors, herbimycin A and genistein, also caused similar effects on ultraviolet-induced apoptosis but to a lesser extent. Serine/threonine kinase inhibitors, K252a, staurosporine and GF109203X, rather suppressed the ultraviolet-induced DNA cleavage. Immunoblot analysis showed that pretreatment with damnacanthal followed by ultraviolet irradiation increased the levels of phosphorylated extracellular signal-regulated kinases and stress-activated protein kinases. However, the other tyrosine kinase inhibitors did not increase the phosphorylation of extracellular signal-regulated kinases but stimulated phosphorylation of stress-activated protein kinases. Consequently, the ultraviolet-induced concurrent increase in both phosphorylated extracellular signal-regulated kinases and stress-activated protein kinases after pretreatment with damnacanthal might be characteristically related to the stimulatory effect of damnacanthal on ultraviolet-induced apoptosis.  (+info)

Terreic acid, a quinone epoxide inhibitor of Bruton's tyrosine kinase. (8/2088)

Bruton's tyrosine kinase (Btk) plays pivotal roles in mast cell activation as well as in B cell development. Btk mutations lead to severe impairments in proinflammatory cytokine production induced by cross-linking of high-affinity IgE receptor on mast cells. By using an in vitro assay to measure the activity that blocks the interaction between protein kinase C and the pleckstrin homology domain of Btk, terreic acid (TA) was identified and characterized in this study. This quinone epoxide specifically inhibited the enzymatic activity of Btk in mast cells and cell-free assays. TA faithfully recapitulated the phenotypic defects of btk mutant mast cells in high-affinity IgE receptor-stimulated wild-type mast cells without affecting the enzymatic activities and expressions of many other signaling molecules, including those of protein kinase C. Therefore, this study confirmed the important roles of Btk in mast cell functions and showed the usefulness of TA in probing into the functions of Btk in mast cells and other immune cell systems. Another insight obtained from this study is that the screening method used to identify TA is a useful approach to finding more efficacious Btk inhibitors.  (+info)

ortho-Quinones are produced in vivo through the oxidation of catecholic substrates by enzymes such as tyrosinase or by transition metal ions. Neuromelanin, a dark pigment present in the substantia nigra and locus coeruleus of the brain, is produced from dopamine (DA) and norepinephrine (NE) via an interaction with cysteine, but it also incorporates their alcoholic and acidic metabolites. In this study we examined the metabolic fate of ortho-quinones derived from the catecholamine metabolites, 3,4-dihydroxyphenylethanol (DOPE), 3,4-dihydroxyphenylethylene glycol (DOPEG), 3,4-dihydroxyphenylacetic acid (DOPAC) and 3,4-dihydroxyphenylmandelic acid (DOMA). The oxidation of catecholic substrates by mushroom tyrosinase was followed by UV-visible spectrophotometry. HPLC analysis after reduction with NaBH4 or ascorbic acid enabled measurement of the half-lives of ortho-quinones and the identification of their reaction products. Spectrophotometric examination showed that the ortho-quinones initially formed
The quinones are a class of organic compounds that are formally derived from aromatic compounds [such as benzene or naphthalene] by conversion of an even number of -CH= groups into -C(=O)- groups with any necessary rearrangement of double bonds, resulting in a fully conjugated cyclic dione structure. The class includes some heterocyclic compounds.. The archetypical member of the class is 1,4-benzoquinone or cyclohexadienedione, often called simply quinone (thus the name of the class). Other important examples are 1,2-benzoquinone (ortho-quinone), 1,4-naphthoquinone and 9,10-anthraquinone.. Quinones are oxidized derivatives of aromatic compounds and are often readily made from reactive aromatic compounds with electron-donating substituents such as phenols and catechols, which increase the nucleophilicity of the ring and contributes to the large redox potential needed to break aromaticity. (Quinones are conjugated but not aromatic). Quinones are electrophilic Michael acceptors stabilised by ...
Quinone is also called 1,4-benzoquinone or cyclohexadienedione. Quinones are oxidized derivatives of aromatic compounds and are often readily made from reactive aromatic compounds with electron-donating substituents such as phenols and catechols, which increase the nucleophilicity of the ring and contributes to the large redox potential needed to break aromaticity. Derivatives of quinones are common constituents of biologically relevant molecules. Some serve as electron acceptors in electron transport chains such as those in photosynthesis (plastoquinone, phylloquinone), and aerobic respiration (ubiquinone ...
Quinones represent a class of toxicological intermediates which can create a variety of hazardous effects in vivo, including acute cytotoxicity, immunotoxicity, and carcinogenesis. The mechanisms by which quinones cause these effects can be quite complex. Quinones are Michael acceptors, and cellular …
Latt and Ahsen sit down with anime and video game voice Actress, Anairis Quinones. Join the duo as they meet with Anairis to discuss her major roles as Harriot Bee, Nessa, and My Hero Academias Mirko! They also delve into diversity in voice acting, c
Cagefighter: Worlds Collide (2020) réalisé par Jesse Quinones. Linformation sur le film, genre, classement, durée, photos, bande-annonce, synopsis et critiques des usagers.
Octagons is a Cage Fighting lyrical powerhouse, laid over bass-drop fuelled, punchy US-style beats.. Sponsors by Fight Gritty, Epic Studios, Contenders MMA. Artist: Jab Singh. Director: Jesse Quinones. ...
The mechanisms underlying this programmed elevation afterwards in existence pursuing an adverse in utero atmosphere a1062368-62-0re nevertheless to be decided.
Quinones can be cytotoxic through several mechanisms of action, including redox cycles, arylation of the thiol groups of proteins, intercalation, induction of breaks in the DNA chain, generation of free radicals and other reactive oxygen species (ROS) and bioreductive alkylation via the formation of quinone methide. However, it is still unclear whether one mechanism of action is more prevalent than the others. Synthetic analogs can be modulated to act selectively via one of several mechanisms of action, especially when the structures of the synthesized molecules are similar to the natural or endogenous quinones of the organisms. In these cases, it is reasonable that these analogs can act in the same way and interfere in the same cellular biochemical processes. For example, quinones are involved in the intracellular transport of electrons, and it is generally accepted that exogenous quinones can transfer electrons in biological processes; this is an important cyclic property as oxidation is ...
Physiological quinones carrying isoprenoid side chains have been compared with homologues lacking the side chain, for their ability to carry electrons and protons from dithionite to ferricyanide, trapped in liposomes. Six differential observations were made: (1) Plastoquinone and ubiquinones, with a side chain of more than two isoprene units, are by far better mediators than their short-chain homologues. Also other benzoquinones lacking a long side chain are poor catalysts, except dimethyl-methylenedioxy-p-benzoquinone, a highly autooxidizable compound. Tocopherol is a good catalyst. (2) Vitamin K-1 and K-2 are poor mediators compared to vitamin K-3. (3) The reaction catalyzed by quinones carrying long isoprenoid side chains has an about three-fold higher activation energy, irrespective of the catalytic efficiency. (4) The reaction catalyzed by quinones lacking a long side chain follows pseudo first-order kinetics, while the reaction with quinones carrying a long side chain is of apparently higher order
1. A comparison is made of several procedures for the extraction of tocopherols and isoprenoid quinones from plant tissues. 2. Gradient-elution column chromatography on acid-washed alumina efficiently separates the isoprenoid quinones and tocopherols into groups that can then be assayed spectrophotometrically or, with the tocopherols, separated into their individual components and determined by gas-liquid chromatography. 3. This improved analytical procedure was used to study the distribution of the tocopherols and of ubiquinone in the ungerminated wheat grain.. ...
The quinones represent a class of organic compounds that are formally derived from aromatic compounds [such as benzene or naphthalene] by conversion of an even number of -CH= groups into -C(=O)- groups with any necessary rearrangement of double bonds, resulting in a fully conjugated cyclic dione structure. The class includes some heterocyclic compounds. A large scale industrial application of quinones is for the production of hydrogen peroxide. Natural quinones show a biological or pharmacological activity, and some of them show anti-tumoral activity. They embody some claims in herbal medicine. Some quinone derivatives are used for coloring substances (dyes and pigments) and oxidizing agents.. ...
Quinones Coat of Arms and Quinones Family Crest. Learn about the history of this surname and heraldry from our database and online image library.
All experimentally characterized proteins in this family are 1,4-benzoquinone reductases. These are intracellular enzymes involved in the biodegradation of aromatic compounds and in the protection of fungal cells from reactive quinone compounds ...
Cordiachromes A-F are terpenoid benzoquinones isolated from the heartwood of . Cordiachrome C (3; R = H) has a benzogeijerene and A (1; R = H) and B (2; R = H) have a benzocogeijerene skeleton. Cordiachromes D-F are methoxy-derivatives of A-C, respectively. All six are optically inactive. Biogenetically they appear
Find Latest Custom Import Duty in India of HS code 2914 KETONES QUINONES OXYGEN FUNCTION HALOGENATED. View Indian customs tariff, taxes, Import duty calculator rates Charts.
The bistability in the position of the two hydrogen atoms in the inner cavity of single free-base naphthalocyanine molecules constitutes a two-level system that was manipulated and probed by low-temperature scanning tunneling microscopy. When adsorbed on an ultrathin insulating film, the molecules can be switched in a controlled fashion between the two states by excitation induced by the inelastic tunneling current. The tautomerization reaction can be probed by resonant tunneling through the molecule and is expressed as considerable changes in the conductivity of the molecule. We also demonstrated a coupling of the switching process so that the charge injection in one molecule induced tautomerization in an adjacent molecule.. ...
Quantitative determination of quinone chromophores in isolated lignins. . Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.
Written by: Alan BurnettArt by: Ty TempletonCover Art by: Joe Quinones Deathstroke makes his move against the Dark Knight, but hes not just going to strike at him physically - hes going to try to destroy him completely by using the rest of the Bat-Family against him!
John Quinones is the well-known Emmy award-winning co-anchor of ABCs Primetime and a series of reports entitled What Would You Do?
Gentaur molecular products has all kinds of products like :search , Kamiya \ Herbimycin A \ KT-375 for more molecular products just contact us
Arnie Quinones Community Meeting: Part 12020-02-26T18:30:00. Join us for a series of community park design meetings, and to let us know what features you would like to see included at Arnie Quinones Park, Phase II. Project will be submitted for State and/or County grant funds for construction. The meetings will be held in two parts: Part 1: An overview and discussion of proposed park amenities. Part 2: Presentation of a site plan for resident review and comment.. Gregg Anderson Academy5151 West Avenue N-8PalmdaleCA93551 ...
MDPen is a MicroNeedling device that moves at speeds up to 17,500 RPM creating 15,000 micro channels per square inch for maximum coverage and a more complete treatment. ...
usage: any of several quinones found in living cells and that function as coenzymes that transfer electrons from one molecule to another in cell ...
TY - JOUR. T1 - Slow loss of deoxyribose from the N7deoxyguanosine adducts of estradiol-3,4-quinone and hexestrol-3′,4′-quinone.. T2 - Implications for mutagenic activity. AU - Saeed, Muhammad. AU - Zahid, Muhammad. AU - Gunselman, Sandra J.. AU - Rogan, Eleanor. AU - Cavalieri, Ercole. PY - 2005/1. Y1 - 2005/1. N2 - A variety of evidence has been obtained that estrogens are weak tumor initiators. A major step in the multi-stage process leading to tumor initiation involves metabolic formation of 4-catechol estrogens from estradiol (E 2) and/or estrone and further oxidation of the catechol estrogens to the corresponding catechol estrogen quinones. The electrophilic catechol quinones react with DNA mostly at the N-3 of adenine (Ade) and N-7 of guanine (Gua) by 1,4-Michael addition to form depurinating adducts. The N3Ade adducts depurinate instantaneously, whereas the N7Gua adducts depurinate with a half-life of several hours. Only the apurinic sites generated in the DNA by the rapidly ...
The invention relates to benzoquinone ansamycin analogs useful for the treatment of cancer and other diseases or conditions characterized by undesired cellular proliferation or hyperproliferation. Therapies involving the administration of such benzoquinone ansamycin analogs, optionally in combination with an inhibitor of an HSP90 client protein, are useful to treat cancer and non-cancerous disease conditions.
1. HT-29 M6 cells are a subpopulation of HT-29 cells that, contrarily to the parental cells, establish tight cell contacts and differentiate. Cell-to-cell contacts in HT-29 M6 cells are also regulated by protein kinase C; addition of the phorbol ester phorbol 12-myristate 13-acetate (PMA) decreases the homotypic contacts of these cells. We show here that HT-29 cells or HT-29 M6 cells treated with PMA contain lower levels of functional E-cadherin, determined by analysing the association of this protein with the cytoskeleton. No significant differences in the localization of α-, β-, or p120-catenins were detected under the three different conditions. 2. Dysfunction of E-cadherin can be reversed by incubation of HT-29 cells with the tyrosine kinase inhibitor herbimycin A. On the other hand an augmentation of c-src activity in HT-29 cells or HT-29 M6 cells treated with PMA was observed with respect to control HT-29 M6 cells. The phosphorylation status of catenins was also investigated; in HT-29 or ...
TY - JOUR. T1 - NAD(P)H:quinone oxidoreductase 1 Arg139Trp and Pro187Ser polymorphisms imbalance estrogen metabolism towards DNA adduct formation in human mammary epithelial cells. AU - Singh, Seema. AU - Zahid, Muhammad. AU - Saeed, Muhammad. AU - Gaikwad, Nilesh W.. AU - Meza, Jane L.. AU - Cavalieri, Ercole L.. AU - Rogan, Eleanor G.. AU - Chakravarti, Dhrubajyoti. PY - 2009/10. Y1 - 2009/10. N2 - Estrogens (estrone, E1; estradiol, E2) are oxidized in the breast first to catechols and then to form two ortho-quinones (E1/2-3,4-Q) that react with DNA to form depurinating adducts, which lead to mutations associated with breast cancer. NAD(P)H:quinone oxidoreductase 1 (NQO1) reduces these quinones back to catechols, and thus may protect against this mechanism. We examined whether the inheritance of two polymorphic variants of NQO1 (Pro187Ser or Arg139Trp) would result in poor reduction of E1/2-3,4-Q in normal human mammary epithelial cells (MCF-10F) and increased depurinating adduct formation. An ...
Although boric acid is known to complex with various polyalcohols, it is often used as a component of buffer mixtures. Electrochemical and spectrophotometric experiments have shown that borate buffers exhibit two types of interference with ortho quinone redox systems. Ortho quinones themselves exist in equilibrium with electroinactive complexes in borate solutions. The corresponding hydroquinones formed by reduction of the quinones complex even more strongly giving complexes which may be oxidized back to the quinone, but at a much higher potential than for the hydroquinone.. ...
Herbimycin A, 1 mg. Herbimycin A, a benzoquinoid ansamycin antibiotic, irreversibly and selectively inhibits tyrosine kinases by reacting with thiol groups (1,2).
Interpretive Summary: [This article is a review of the past 30 years of research by our group (and others) on quinone methides, important intermediates associated with lignin.] Lignins are large complex molecules that are prominent in plant cell walls, perhaps accounting for as much as 20% of terrestrial biomass. They hold together the fibers, and are involved in plant defense and water transport throughout the plant. Lignins are made from coupling reactions of the small-molecule lignin building blocks, with each other or, more importantly, with the growing, large complex molecule. Each coupling reaction produces an intermediate structure, a quinone methide, that then reacts in various ways to produce the final structure in lignin. Therefore, quinone methide reactivity and structure are key factors in the important process of lignification. Lignification, and the reactions of the intermediary quinone methides in particular, are increasingly seen as crucial to understanding the key role of lignin ...
TPH is presently shown to be inactivated after exposure to DA under specified conditions. All aspects of the data support the conclusion that DA-derived quinones are the agents mediating the inactivation. First, preincubation with DA alone had no effect on TPH activity. Second, conditions that prompt the conversion of DA to one of its quinones lead to significant reductions in TPH catalytic function. Because DA can be the source of numerous, different quinones (Graham, 1978; Graham et al., 1978; Kelgaris et al., 1995), we tested three representative ones in an attempt to establish the generality of their effects on TPH. DA was oxidized by iron + H2O2to semiquinones and quinones as described in Equations 1-3. DA was also converted enzymatically to the aminochrome by tyrosinase, and finally, N-acetyl-DA was oxidized by NaIO4 to the more stable o-quinone (Graham, 1978; Graham et al., 1978). Each quinone caused significant inactivations of TPH. Third, GSH, DTT, and ascorbic acid protected TPH from ...
The cytotoxic and antiproliferative properties of many natural sesquiterpene-quinones and -hydroquinones from sponges offer promising opportunities for the development of new drugs. A review dealing with different strategies for obtaining bioactive terpenyl quinones/hydroquinones is presented. The different synthetic approches for the preparation of the most relevant quinones/hydroquinones are described.
Competing models of mitochondrial energy metabolism in the heart are highly disputed. In addition, the mechanisms of reactive oxygen species (ROS) production and scavenging are not well understood. To deepen our understanding of these processes, a computer model was developed to integrate the biophysical processes of oxidative phosphorylation and ROS generation. The model was calibrated with experimental data obtained from isolated rat heart mitochondria subjected to physiological conditions and workloads. Model simulations show that changes in the quinone pool redox state are responsible for the apparent inorganic phosphate activation of complex III. Model simulations predict that complex III is responsible for more ROS production during physiological working conditions relative to complex I. However, this relationship is reversed under pathological conditions. Finally, model analysis reveals how a highly reduced quinone pool caused by elevated levels of succinate is likely responsible for the ...
Ilyas Washington from Columbia University Medical Center will be delivering a seminar on How Inhibiting The Dimerization Of Vitamin A and/or Catalyzing The Reduction of Quinones May Prevent Retinal Degeneration on Wednesday, February 11th, 2015 in the Moran Eye Center auditorium. Abstract: Many human conditions, originating from multiple genetic and environmental pressures, converge to overproduce superoxide radical anions. The […]. ...
Dr. Ruckers research focus is on the role of nutrients in early growth and development and the physiological roles of quinone cofactors derived from tyrosine, such as pyrroloquinoline quinone.
Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Nanoteknologi och funktionella material. (Nanoteknologi och Funktionella Material) ...
Sign up for our 100% Free Daily Grindhouse Newsletter. Youll receive instant access to exclusive insider movie content, member only deals, first dibs at limited editions, and more. Its the greatest cult movie newsletter in the world!. Add your email here for great cult movie content:. ...
June 16, 2021: Announcement Party for A Writers Garden Literary Symposium 2021 and Luncheon. Private Home. Questions contact Betty Suellentrop [email protected] June 25: Pot of Gold Luncheon featuring Best-selling author Josh Shipp benefiting Rainbow Days, Inc. Kyle Coots, co-founder and managing director of Miramar Equity Partners and Ross DeRogatis, president and owner of Matrix Orthopedics, Chairs.. * To see your event listed here, click here for Submission Guidelines.. ...
E.P.I.C Pride, Highlighting the latest LGBTQ news in Entertainment, Politics, International affairs, and Culture. - Caitlyn Jenner Running For California.... Read more ...
Title:Hydroxysafflor Yellow A Attenuates Renal Ischemia- Reperfusion Injury in a Rat Model. VOLUME: 9 ISSUE: 10. Author(s):Weiran Chai, Wenhui Zhang, Zhu Jin, Yanqian Zheng, Peiyao Jin, Qiaoyan Zhang and Jianming Zhi. Affiliation:Department of Physiology, Shanghai Jiaotong University, School of Medicine, Chongqing South Road 280, Shanghai 200025, China.. Keywords:Hydroxysafflor yellow A, Ischemia/reperfusion injury, Renal, Antioxidant enzymes, Malondialdehyde, Myeloperoxidase, hemorrhagic shock, Carthamus tinctorius, renal I/R, Acute renal failure. Abstract:Hydroxysafflor Yellow A (HSYA) is one of the most important active ingredients of Carthamus tinctorius L, and has long been widely used in the treatment of cardiovascular diseases in China. The purpose of this study was to evaluate the role of HSYA in protecting the kidney against ischemia/reperfusion injury (IRI). Male Wistar albino rats (200-250 g) were unilaterally nephrectomized and subjected to 45-min renal ischaemia and 24-h ...
Water soluble quinones are a group of cytotoxic anti-bacterial compounds that are secreted by many species of plants, invertebrates, fungi and bacteria. Studies in a number of species have shown the importance of quinones in response to pathogenic bacteria of the genus Pseudomonas. Two electron reduction is an important mechanism of quinone detoxification as it generates the less toxic quinol. In most organisms this reaction is carried out by a group of flavoenzymes known as NAD(P)H quinone oxidoreductases. Azoreductases have previously been separate from this group, however using azoreductases from Pseudomonas aeruginosa we show that they can rapidly reduce quinones. Azoreductases from the same organism are also shown to have distinct substrate specificity profiles allowing them to reduce a wide range of quinones. The azoreductase family is also shown to be more extensive than originally thought, due to the large sequence divergence amongst its members. As both NAD(P)H quinone oxidoreductases and
CD20 is a B cell-specific 35/37 kDa integral membrane protein which modulates proliferation and differentiation of normal resting B cells when stimulated by CD20 antibodies. An increase in c-myc mRNA levels occurs within hours after treatment of resting B cells with CD20 mAb; however earlier events in the CD20 signal transduction pathway have not been described. Here we demonstrate that anti-CD20 mediated induction of c-myc mRNA is inhibited by the tyrosine kinase inhibitor herbimycin A, that CD20 is associated with both tyrosine and serine kinase activity, and that tyrosine phosphorylation of multiple substrates is induced within minutes upon ligation of CD20 with mAb. Association of the tyrosine and serine kinases with CD20 was stable in lysis buffer containing 1% NP40 and 0.25% deoxycholate. Under the same conditions, antibodies against several other B cell surface molecules failed to co-precipitate tyrosine kinase activity, however, a serine kinase was precipitated by the anti-CD19 mAb, B43. ...
Abstract Alanine triazole Mn-catalyzed 1,6-conjugate coupling/aromatization of para-quinone methides was developed with good to high yields under mild conditions. This protocol provided an efficient and practical route to the synthetically interesting functionalized methines and their analogues. Preliminary mechanistic experiments revealed 1,6-conjugate addition of nucleophiles to para-quinone methides (p-QMs). The manganese was acted as the Lewis acid.. ...
Chemical behavior of the oxopurines 8-oxoadenosine and 8-oxoinosine has been investigated. Purine quinones, pivotal intermediates in oxidation of oxopurines were successfully trapped and the resulting products were characterized. Formation of purine quinones was demonstrated with both chemical and photochemical oxidizing agents. Adducts formed as a result of reaction of purine quinones with nucleophiles were isolated and characterized. Pyrene dihydrodioxins have been synthesized and shown to be effective agents for release of pyrene-4,5-dione. Pyrene-4,5-dione is an effective DNA photo-oxidation agent. Pyrene dihydrodioxin incorporating a pyridinium salt as a possible internal electron trap has been shown to release pyrenequinone rapidly. Dihydrodioxins containing two pyridine and pyridinium salt moieties have been synthesized and characterized by variety of methods including 1H and 13C NMR spectroscopy. Dihydrodioxin containing two pyridine moieties was separated into D and L enantiomers via liquid
Understanding the Complexity of Estrogen Detoxification: How Genetics, the Liver, and the Microbiome Come Together. By: Dr. Carrie Jones, ND, MPH. Sponsored By: Precision Analytical. ​. Estrogen goes through phase 1 and phase 2 detoxification known collectively as estrogen metabolism. Once water soluble, estrogen must leave the cell and enter phase 3 detoxification. A healthy metabolism shunts estrogen into 2-OH-E1 and then through methylation via COMT into 2-methoxy-E1 for proper disposal from the body. Unfortunately, if the pathway turns towards the unhealthy 4-OH-E1 or does not go through methylation, those estrogens go on to form a quinone that can result in DNA damage and increased cancer risk. Certain enzymes, such as Quinone Reductase and Glutathione-S-Transferase, help prevent or reverse quinone formation and can be optimized with specific dietary changes and natural products. It is also important to evaluate the gut as the microbiome has a huge influence on b-glucuronidase and the ...
Welcome to the Taberhood, Quinones family! New homebuyer Eric Quinones found his home in Ponderosa Estates in Piedmont, Oklahoma.My name is Eric. We live in the Ponderosa addition off of 122nd and Council Road. We wanted to build a house from the ground up, so that way it could be very customized to us and meet all of our needs.We have a lot of children. We have five kids and we wanted to be able to put all five children in their own space, so they could have their own room. Building from the
Fingerprint Dive into the research topics of Cytochrome P450 isoforms catalyze formation of catechol estrogen quinones that react with DNA. Together they form a unique fingerprint. ...
Studies toward the Total Synthesis of Parvifolals A/B: An Intramolecular o‑Quinone Methide [4 + 2]-Cycloaddition To Construct the Central Tetracyclic Core
Looking for online definition of Sphingobacterium in the Medical Dictionary? Sphingobacterium explanation free. What is Sphingobacterium? Meaning of Sphingobacterium medical term. What does Sphingobacterium mean?
Role of nicotinamide quinone oxidoreductase 1 (NQO1) in protection against toxicity of electrophiles and reactive oxygen intermediates
Amino-acid radical enzymes have been studied extensively for 30 years but the experimental barriers to determine the thermodynamic properties of their key radical cofactors are so challenging that only a handful of reports exist in the literature. This is a major drawback when trying to understand the long-range radical transfer and/or catalytic mechanisms of this important family of enzymes. Here this issue is addressed by developing a library of well-structured model proteins specifically designed to study tyrosine and tryptophan radicals. The library is based on a 67-residue three-helix bundle (α3W) and a 117-residue four-helix bundle (α4W). α3W and α4W are single-chain and uniquely structured proteins. They are redox inert except for a single radical site (position 32 in α3W and 106 in α4W). Papers I and II describe the design process and the protein characteristics of α4W as well as a voltammetry study of its unique tryptophan. Paper III and V describe two projects based on α3C, ...
56815-78-2 - UMOZFNODOJXMKD-UHFFFAOYSA-J - Platinum (IV), bis(cyclopentylammine)tetrachloro-, cis- - Similar structures search, synonyms, formulas, resource links, and other chemical information.
Posted on November 9, 2012 by Sam Quinones. One story that emerged from the Tell Your True Tale writing workshops I did with students at San Joaquin Delta College in Stockton was Saturday …. By Alexandria Hendon. …That year we moved in with him, he and I were inseparable, but it hadnt always been that way. He denied me as his daughter several times. He had come and gone as he pleased. Each time he decided he wanted to be around my mom, my brothers, and me, he stayed around for a week or so. In that week, he would take us to dinner, zoos, and riding in go-carts. Then we wouldnt see him for months. Every time he left, I would lose a dad all over again.. As I grew older, I learned that every time he left, he had gotten some girl pregnant. As far as I know, we have four half brothers and one half sister. My mom and dad would always fight, mainly because of his cheating, but for some reason, she would always take him back. …. Continue Reading ...
[65 Pages Report] Check for Discount on TETRAHYDROXY-1,4-QUINONE HYDRATE Global Market and Forecast Research report by ChemReport. DescriptionWe provide independent and unbiased information on manufacturers, prices, production...
Perhaps less lighthearted than previous April Fools posts, this one reflects my continuing frustration with some of the (to put it politely) refuse published in the literature. Compound 1 is a known hydrogen-peroxide generator (which would inactivate cysteine proteases) and compound 2 is an electrophilic rhodanine (which Jonathan Baell has memorably referred to as polluting the literature). I added the catechol (which can form reactive ortho-quinones) in compound 4 just to push things completely over the top ...
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Supplementary MaterialsAdditional document 1: Shape S1. epidermis to regulate sclerotization. Figure S7. Sclerotization, quantified using other protein bands, show that RK function is necessary but not sufficient in the CNS to regulate sclerotization. Figure S8. Abdominal pigmentation in males in which Tubastatin A HCl inhibitor RK function was downregulated in peptidergic, CCAP, and ILP7 neurons. Figure S9. RK function is necessary in peptidergic neurons that are not CCAP immunopositive to regulate melanization. Figure S10. Some ILP7-immunopositive neurons express knockdown efficiency. (PDF 10369 kb) 12915_2020_742_MOESM1_ESM.pdf (10M) GUID:?46894A39-2E1B-47AE-807B-007034AF033B Data Availability StatementAll data generated or analyzed during this study are included in this published article and its supplementary information files. Abstract Background In insects, continuous growth requires the periodic replacement of the exoskeleton. Once the remains of the exoskeleton from the previous stage ...
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1K6L: The structure of a mutant photosynthetic reaction center shows unexpected changes in main chain orientations and quinone position.
It has been established earlier that lipids (phosphatidyl glycerol, phosphatidyl inositol, cardiolipin) being subjected to radiolysis undergo fragment..
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I am a freelance illustrator known to reside somewhere within the six states of New England -and New York too. Im currently settled in a cozy little nook in Somerville, Massachusetts. True. Email: me at joequinones dot ...
Institutions of higher education continue to be economic drivers, not just in Westchester County, but across New York state. Private not-for-profit colleges and universities in ...
Display omitted] New sesquiterpene quinones, metachromins X (1) and Y (2), together with the known metachromins C (3), J (4), and T (5), were isolated as ...
White Out Medical Peel contains natural quinones to help inhibit production of new pigmentation, leaving the skin smoother, brighter and even in color.
Quinones, Manuel; Schor, Elana (July 26, 2011). "Sen. Manchin Maintains Lucrative Ties to Family-Owned Coal Company". The New ...
313.2(b). Gastelnum-Quinones. In re Pruna. In the Matter of C--. Turner, 512 U.S. at 642. Pellegrino. Tilner, p. 32. Tilner, p ... Galvan v. Press, 347 U.S. 737 (1954). Gastelnum-Quinones v. Kennedy, 374 U.S. 469 (1963). Kleindienst v. Mandel, 408 U.S. 753 ( ...
Luciano Quinones. 2016. Accessed 3 May 2016. Biblioteca Escuela Elemental Julio Alvarado Tricoche. Escuela Elemental Julio ...
Murr, L.; Quinones, S.; Gaytan, S.; Lopez, M.; Rodela, A.; Martinez, E.; Hernandez, D.; Martinez, E.; Medina, F.; Wicker, R., ...
Quinones, John; Ellis Angela; Clarke Suzan (24 June 2010). "Anita Van Der Sloot Said Sneaky Son Would Leave House at Night for ... Quinones, John; Netter, Sarah; Goldman, Russell (11 June 2010). "Joran van der Sloot Pelted With Rotten Vegetables on Way to ... Quinones, John; Kunin, Sarah; Ferran, Lee (1 July 2010). "Sources: Joran van der Sloot Seeking $1 Million TV Deal". Good ...
Quinones, Todd; Gregg, Cherri (September 10, 2013). "Hillary Clinton Awarded 2013 Liberty Medal". KYW-TV. "Hillary Rodham ...
Quinones, Sam; Hennessy-Fiske, Molly; Powers, Ashley (January 11, 2011). "A troubled mind in Tucson". Los Angeles Times. "Jared ... Quinones, Sam (January 10, 2011). "Jared Lee Loughner's parents alone with their anguish, neighbor says". Los Angeles Times. ...
Quinones, Nelson. "31 children killed after bus catches fire in Colombia". CNN. Retrieved 20 May 2014. CS1 maint: discouraged ...
Quinones, Sam; Winton, Richard; Mozingo, Joe (January 25, 2013). "Attack on family in Compton latest incident in wave of anti- ...
"Luis Quinones". baseball-reference.com. Retrieved 2008-01-21. "Rey Quinones". baseball-reference.com. Retrieved 2008-01-21. " ...
Quinones, Mariam; Koo, Lily (2012-08-31). "Compartmentalized control of skin immunity by resident commensals". Science. 337 ( ... Quinones, Mariam (2015-10-08). "Microbiota-Dependent Sequelae of Acute Infection Compromise Tissue-Specific Immunity". Cell. ...
Quinones, Sam. "The Jotos of La Fogata" chapter 4 in True Tales of Another Mexico. Albuquerque: University of New Mexico Press ...
Adler, AS; McCleland, ML; Yee, S; Yaylaoglu, M; Hussain, S; Cosino, E; Quinones, G; Modrusan, Z; Seshagiri, S; Torres, E; ...
Rivera, Gabby; Quinones, Joe (2017). America Vol. 1: The Life and Times of America Chavez. New York City, New York: Marvel. ... Rivera, Gabby; Quinones, Joe; Wu, Annie (2018). America Vol. 2: Fast and Fuertona. New York City, New York: Marvel. ISBN 978- ...
Winton, Richard; Quinones, Sam. "Family members allegedly ran heroin smuggling ring". Los Angeles Times. Williams, Kidman. "How ...
Quinones, Javier. "Oscar Castro-Neves: Playful Heart". JazzTimes. JazzTimes Inc. Retrieved 3 May 2016. Chawkins, Steve. "Oscar ...
Quinones, J.; Acha, M.; Harvey, M.; Arthur, J. M.; Graham, W. M. (2013). "Recurrent jellyfish blooms are a consequence of ...
Quinones, Javier; Salka, Scott; Bishop-Lilly, Kimberly A.; Young, Ry; Hamilton, Theron (14 August 2017). "Development and Use ...
Mozingo, Joe; Quinones, Sam; Winton, Richard (February 23, 2008). "A gang's staying power". Los Angeles Times. Rubin, Joel ( ... Quinones, Sam (February 5, 2009). "Avenues gang bastion is demolished". Los Angeles Times. Logan, Tim (December 21, 2014). " ...
Quinones, Miriam; Moloney, Síle (6 May 2020). "New Covid-19 ICU Opens at North Central Bronx Hospital". Norwood News. Retrieved ...
Quinones, Sam. "Novices threaten Cudahy's status quo." Los Angeles Times. January 2, 2007. 1. Retrieved on October 26, 2009. ... Quinones, Sam. "Novices threaten Cudahy's status quo." Los Angeles Times. January 2, 2007. 2. Retrieved on October 26, 2009. " ... Sam Quinones of the Los Angeles Times said that the large, narrow parcels of land gave Cudahy Acres a "rural feel in an ...
Quinones, Sam; Rong-Gong Lin II; Andrew Blankstein (2009-05-19). "Rapper Dolla is shot, killed in front of his soon to be wife ... Dekalb County Georgia OJS Quinones, Sam (2009-05-19). "Rapper Dolla is shot, killed in an LA shopping centre. Center". Los ...
John Quinones; Laura Viddy; Cecile Bouchardeau (September 12, 2007). "Hypertrichosis - Real Life Werewolves?". ABC News. ...
Martinez, Michael; Quinones, Nelson; Brumfield, Ben (September 12, 2015). "Tom Cruise movie crew members in plane crash that ...
Quinones, Sam. "Touch of Evil". Bookforum. Retrieved 11 May 2012. Gordon, Ian (25 October 2011). "Book Review: El Narco". ...
Quinones, Sam; Hoagland, Eros (21 November 2014). "In Tijuana, Mexicans Deported by U.S. Struggle to Find 'Home'". National ...
Quinones, MA; Roden, DM; Silka, MJ; Tracy, C; Smith SC, Jr; Jacobs, AK; Adams, CD; Antman, EM; Anderson, JL; Hunt, SA; Halperin ...
Tarentino, A.L.; Quinones, G.; Grimwood, B.G.; Hauer, C.R.; Plummer, T.H. Jr. (1995). "Molecular cloning and sequence analysis ...
ISBN 978-3-319-42524-5 Cury, P; Bakun, A; Crawford, RJM; Jarre, A; Quinones, RA; Shannon, LJ; Verheye, HM (2000). "Small ...
Quinones, Sam; Murphy, Kim; Mozingo, Joe (July 22, 2012). "Profile of Aurora shooting suspect keeps getting murkier". Los ...
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... September 4, 2014. Francisco Real killed people. He smuggled illegal immigrants. He sold drugs and collected ...
Quinones M.. Mapping the Climate of Puerto Rico, Vieques and Culebra. Thu, 05/10/2012 - 13:53 - leonmi DALY C.,HELMER E. H., ...
Quinone. CAS No: 106-51-4. NOTE:. (1) Efficacy of Medical Tests has not been evaluated.. (2) NIOSH references include ... Quinone. Editor(s). /Author(s). Specific Medical Test(s) or Examination(s). Reference(s). ...
Linnea Quinones - FIFA competition record Linnea Quinones at Soccerway. Retrieved 2 January 2020. "Linnea Andrea Quinones, Born ... Linnea Andrea Quiñones Sandland (born 17 July 1980), known as Lenny Quinones, is an American-born Mexican former footballer who ... Quinones played for Mexico at senior level in the 1999 FIFA Womens World Cup. ...
Contenay-Quinones is the daughter of Carmen Quinones, a painter from Lima, Peru and was influenced by a wide variety of music ... In 2000, Quinones provided vocals on the Dario G song "Voices" on the soundtrack to the Leonardo DiCaprio film The Beach. In ... June 2011, Quinones released a specially written song "Show Me How" for the Vinyl Japan/Red Cross charity album for children ... In 1992, Quinones and Taplin signed a recording contract with Heavenly Records (then in a distribution deal with Arista Records ...
alexquinones7 has 0 followers and a follower/following ratio of 0. Last month alex quinones tweeted 0 time and unfollowed 0 ... alex quinones Twitter Stats. @alexquinones7 - Tracking alex quinones Twitter profile since December 12, 2012 puerto rico ... Why dont you give it a try and compare alex quinones to yourself ? Or if you are alex quinones get even more feature rich & up ... alex quinoness story. alex quinones, also known as @alexquinones7 has a reasonably significant presence on Twitter and is ...
Last month Alex Quinones tweeted 2,559 times and followed 148 user. At this pace @alexquinones26 will hit 307 followers in the ... Alex Quinones Twitter Stats. @alexquinones26 - Tracking Alex Quinones Twitter profile since February 2, 2014 North Olmsted 18 ... Why dont you give it a try and compare Alex Quinones to yourself ? Or if you are Alex Quinones get even more feature rich & up ... Alex Quinoness story. Alex Quinones, also known as @alexquinones26 has a reasonably significant presence on Twitter and is ...
Jesse Quinones , Cagefighter (EP.6) ,, This, the final of our Verve Magazine interview series willl be ending with the very ...
... has role cofactor (CHEBI:23357) pyrroloquinoline quinone (CHEBI:18315) has role water- ... pyrroloquinoline quinone (CHEBI:18315) is a orthoquinones (CHEBI:25622) pyrroloquinoline quinone (CHEBI:18315) is a ... pyrroloquinoline quinone (CHEBI:18315) is a tricarboxylic acid (CHEBI:27093) pyrroloquinoline quinone (CHEBI:18315) is ... pyrroloquinoline quinone(3−) (CHEBI:58442) is conjugate base of pyrroloquinoline quinone (CHEBI:18315). ...
Official profile of Olympic athlete Aydill-Marie COLON QUINONES (born 05 Sep 1998), including games, medals, results, photos, ...
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Quinone, any member of a class of cyclic organic compounds containing two carbonyl groups and a vinylene group in a six- ... The quinones include the benzoquinones, naphthoquinones, anthraquinones, and polycyclic quinones. ... In a few quinones, the carbonyl groups are located in different rings. The term quinone also denotes the specific compound para ... a transport molecule called a quinone, located at the opposite side of the membrane. The quinone returns the electron back ...
Marc Quinones Signature Series Designed in conjunction with one of todays premier percussionists, Marcs timbale set consists ...
Tag: Brian quinones. Facebook Live Video Shows Minnesota Man Brian Quinones Fatally Shot by Police. News September 9, 2019. by ... A live video posted on Quinones page shows him listening to loud music while driving outside of Minneapolis around 10 p.m., ... A Facebook live video captured the last moments of Minnesota man Brian Quinones, who police shot during a traffic stop Saturday ...
Seminar: How Inhibiting The Dimerization Of Vitamin A and/or Catalyzing The Reduction of Quinones May Prevent Retinal ... Center will be delivering a seminar on How Inhibiting The Dimerization Of Vitamin A and/or Catalyzing The Reduction of Quinones ...
Lantie Quinones, MD is a Addiction Psychiatry Specialist in Reston, VA. She has indicated that she accepts telehealth ... Quinones. Reviews. Be the first to leave a review. How likely are you to recommend. Dr. Quinones. ?. Poor. Fair. Good. Very ... Lantie Quinones, MD offer telehealth services?. Dr. Quinones has indicated that they offer telehealth. Contact the office to ... Lantie Quinones, MD accept my insurance?. Use the Healthgrades insurance check to verify if Dr. Quinones accepts your insurance ...
Polycyclic quinones: The polycyclic quinones occur in some bacteria, fungi, and parts of higher plants. One of the more ... Other articles where Polycyclic quinone is discussed: coloration: ... In coloration: Polycyclic quinones. The polycyclic quinones occur in some bacteria, fungi, and parts of higher plants. One of ...
1. quinone, benzoquinone, compound, chemical compound. usage: any of a class of aromatic yellow compounds including several ...
... p-Quinone Pale-yellow solid with an acrid, chlorine-like odor. ...
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Armando Quinones. Senior Loan Officer, Monarch Mortgage - A Division of Monarch Bank. 600 Jefferson Plaza, Suite 360 Rockville ...
Quinone imines represent a class of biological reactive intermediates that has been the focus of intensive toxicological ... 1986) Quinone Imines as Biological Reactive Intermediates. In: Kocsis J.J., Jollow D.J., Witmer C.M., Nelson J.O., Snyder R. ( ... Two representative quinone imines that have been subjects of research in this laboratory and others are shown in Fig. 1. These ... Quinone imines represent a class of biological reactive intermediates that has been the focus of intensive toxicological ...
DentalPlans detailed profile of Rosalie Quinones , DDS - Dentist in 00918. View plans, sample savings & pricing, patient ... Rosalie Quinones is a General Dentist practicing in SAN JUAN, PR.. This provider has not yet shared a personalized biography. ... Rosalie Quinones Accepts The Plans Below Compare plans or review sample savings for each plan below ...
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Frankie Quinones biography and upcoming performances at selected Improv comedy clubs. Frankie Quiñones is a stand-up comedian ... Frankie Quinones Bio. Frankie Quiñones is a stand-up comedian best known for his character work. He tours as himself, but also ...
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United States of America v. Herman Quinones, Antonio Quinones. , September 05, 2011 at 12:00 AM ...
ABC News journalist and host of What Would You Do? John Quiñones spoke to students in a visit to El Paso Community Colleges Valle Verde Campus.
  • NADH:quinone oxidoreductase (complex I) pumps protons across the inner membrane of mitochondria or the plasma membrane of many bacteria. (nih.gov)
  • Jun and Fos regulation of NAD(P)H: quinone oxidoreductase gene expression. (nih.gov)
  • Jarrow Formulas PQQ (Pyrroloquinoline quinone) at Netrition.com. (netrition.com)
  • Jarrow Formulas PQQ (Pyrroloquinoline quinone) is an important antioxidant that promotes the creation of new mitochondria, supports heart health and cognitive function. (netrition.com)
  • Jarrow Formulas PQQ (Pyrroloquinoline quinone) promotes mitochondrial biogenesis and supports heart and cognitive function. (netrition.com)
  • CCK-8 assay showed that pyrroloquinoline quinone (PQQ) had little influence on viability of PC12 and SHSY5Y cells. (hindawi.com)
  • Pyrroloquinoline quinone (PQQ) is a recently discovered vitamin-like compound with antioxidant and B-vitamin-like activity that has a wide range of benefits for brain and body function. (naturalfactors.com)
  • Pyrroloquinoline quinone (PQQ) is a naturally occurring redox cofactor that acts as an essential nutrient, antioxidant, and has been reported to exert potent immunosuppressive effects. (wellnessresources.com)
  • NADH dehydrogenase I (NDH-1) shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centres, to quinones in the respiratory chain. (ebi.ac.uk)
  • Here we report five crystal structures of T. thermophilus enzyme in complex with NADH or quinone-like compounds. (nature.com)
  • Crystal structures show that binding of quinone-like compounds (but not of NADH) leads to a related global conformational change, accompanied by local re-arrangements propagating from the quinone site to the nearest proton channel. (nature.com)
  • alex quinones, also known as @alexquinones7 has a reasonably significant presence on Twitter and is ranked by us in the 40% percentile for account strength. (twittercounter.com)
  • Active on Twitter since September 2012, alex quinones made it to having a respectable 0 Twitter followers and to being ranked 240,270,679 for number of followers among all Twitter users. (twittercounter.com)
  • You can see how many followers alex quinones lost or gained and what the prediction is for tomorrow or the next 15 days, together with all kinds of other stats like rank compared to all Twitter users, tweets etc. (twittercounter.com)
  • Or if you are alex quinones get even more feature rich & up-to-date stats with our premium Twitter Stats . (twittercounter.com)
  • Active on Twitter since May 2013, Alex Quinones made it to having a respectable 307 Twitter followers and to being ranked 38,203,563 for number of followers among all Twitter users. (twittercounter.com)
  • The polycyclic quinones occur in some bacteria, fungi, and parts of higher plants. (britannica.com)
  • Ali Quinones is organizing this fundraiser on behalf of Evan Thomas. (gofundme.com)
  • Jennifer Harrington and 2 others are organizing this fundraiser on behalf of Corey Quinones. (gofundme.com)
  • Written by critically-acclaimed YA novelist Gabby Rivera ( Juliet Takes A Breath ) and drawn by all-star artist Joe Quinones ( HOWARD THE DUCK ), Marvel Comics' brand new AMERICA series shines a solo spotlight on the high-octane and hard-hitting adventures of the one and only America Chavez! (midtowncomics.com)
  • All known co-factors of complex I reside in the PA: the primary electron acceptor flavin-mononucleotide (FMN) is connected by the redox chain of seven Fe-S clusters to the quinone-binding site (Q-site) at the interface with the membrane domain (Fig. 1 ). (nature.com)
  • Quinone oxidoreductase1 (NQO1) is a flavoprotein which promotes obligatory two-electron reduction of quinones, preventing their participation in redox cycling, oxidative stress and neoplasia. (nih.gov)
  • These quinones transfer electrons in redox reactions. (chemicalbook.com)
  • MLB, GA and EM have filed a PCT application "Cannabinoid quinone derivatives" (application number PCT-03494). (springer.com)
  • Most of free anthracenes and quinone derivatives are sublimable. (chemicalbook.com)
  • Free anthracenes and quinone derivatives can be dissolved in methanol, ethanol, ethyl acetate, ethyl ether, benzene, chloroform and other organic solvents, slightly soluble or insoluble in water. (chemicalbook.com)
  • Quinones also include naphthoquinone , phenanthrenequinone and anthraquinones in a broad way. (chemicalbook.com)
  • According to their different chemical structures, quinone compounds can be divided into benzene quinone , naphthalene quinones , anthraquinones and quinones. (chemicalbook.com)
  • The term quinone also denotes the specific compound para - ( p -)benzoquinone (C 6 H 4 O 2 ). (britannica.com)
  • Understanding the stabilization of the (-)-epicatechin quinone will help to differentiate between flavonoids and to select the appropriate compound for a specific disorder. (nih.gov)
  • Electrochemical Control of microorganisms (Part 9)-Electrochemical cultivation of bacteria using a quinone compound. (worldwidescience.org)
  • Those animals in which they do occur-e.g., sea urchins, aphids, lac insects, and certain scale insects-obtain their quinone compounds from the plants they eat. (britannica.com)
  • Quinones are a class of organic compounds consisting of a six-carbon cyclic dione structure containing two double-bonds, such as p-benzoquinone, o-benzoquinone. (chemicalbook.com)
  • Quinoid structures and their color are closely related, and therefore most of the quinone compounds are colored substances. (chemicalbook.com)
  • Quinones is a class of compounds comprising quinones and compounds easily converted into structures with characteristics of quinones, as well as compounds closely related with the quinones in biosynthesis, often found in nature as pigment in animals, plants, microbes. (chemicalbook.com)
  • The cytotoxic and antiproliferative properties of many natural sesquiterpene-quinones and -hydroquinones from sponges offer promising opportunities for the development of new drugs. (mdpi.com)
  • A review dealing with different strategies for obtaining bioactive terpenyl quinones/hydroquinones is presented. (mdpi.com)
  • The different synthetic approches for the preparation of the most relevant quinones/hydroquinones are described. (mdpi.com)
  • Poisonous ingredients include: Hydroquinones Quinones Sodium thiosulfate Sodium sulfite/bisulfite Boric acid Photographic fixative can also break down (decompose) to form sulfur dioxide gas. (nih.gov)
  • Journalist Sam Quinones, author of "Dreamland: The True Tale of America's Opiate Epidemic," will speak at the Toledo-Lucas County Public Library on Oct. 3. (toledoblade.com)
  • Sam Quinones , author of Dreamland, talks with EconTalk host Russ Roberts about the explosion in heroin use and how one small Mexican town changed how heroin was produced and sold in America. (econtalk.org)
  • This is America in 2015, and as Sam Quinones describes in his astonishing, monumental new book, Dreamland: The True Tale of America's Opiate Epidemic , we're in the midst of "the worst drug scourge to ever hit the country," measuring by its death toll. (themillions.com)
  • On Saturday, October 7, 2017, Cleveland Public Library will host a special event featuring Sam Quinones, the author of Dreamland: The True Tale of America's Opiate Epidemic (Bloomsbury, 2015) in the Louis Stokes Wing of the downtown Main Library. (cpl.org)
  • The major product from DOPE-quinone was DOPEG which was produced through the addition of a water molecule to the quinone methide intermediate. (mdpi.com)
  • DOPEG-quinone yielded a ketone, 2-oxo-DOPE, through the quinone methide intermediate. (mdpi.com)
  • This study confirmed the fact that ortho -quinones from DOPE, DOPEG, DOPAC and DOMA are converted to quinone methide tautomers as common intermediates, through proton rearrangement or decarboxylation. (mdpi.com)
  • Quinones usually are prepared by oxidation of aromatic amines, polyhydric phenols, and polynuclear hydrocarbons. (britannica.com)
  • This relationship led us to postulate that oxidation of the carcinogenic 4-hydroxy catechol estrogens (CE) of estrone (E 1 ) and estradiol (E 2 ) to catechol estrogen-3,4-quinones (CE-3, 4-Q) results in electrophilic intermediates that covalently bind to DNA to form depurinating adducts. (pnas.org)
  • This relationship led us to postulate that oxidation of catechol estrogens (CE) to CE quinones (CE-Q) results in electrophilic intermediates that also covalently bind to DNA and form depurinating adducts. (pnas.org)
  • ortho -Quinones are produced in vivo through the oxidation of catecholic substrates by enzymes such as tyrosinase or by transition metal ions. (mdpi.com)
  • As part of a study on the SAR of phytocannabinoids, we have investigated the effect of the oxidation modification in the resorcinol moiety of cannabigerol (CBG) on CB 1 , CB 2 and PPARγ binding affinities, identifying cannabigerol quinone (VCE-003) as a potent anti-inflammatory agent. (springer.com)
  • A new series of isoxazole tethered quinone-amino acid hybrids has been designed and synthesized involving 1,3-dipolar cycloaddition reaction followed by an oxidation reaction using cerium ammonium nitrate (CAN). (hindawi.com)
  • The most important characteristic reaction of quinones is reduction to the corresponding dihydroxy form. (britannica.com)
  • Ilyas Washington from Columbia University Medical Center will be delivering a seminar on How Inhibiting The Dimerization Of Vitamin A and/or Catalyzing The Reduction of Quinones May Prevent Retinal Degeneration on Wednesday, February 11th, 2015 in the Moran Eye Center auditorium. (utah.edu)
  • HPLC analysis after reduction with NaBH 4 or ascorbic acid enabled measurement of the half-lives of ortho -quinones and the identification of their reaction products. (mdpi.com)
  • The results showed that the reduction of the formed (-)-epicatechin quinone by ascorbate did not result in the formation of an appreciable amount of (-)-catechin. (nih.gov)
  • Having the properties of open-chain dicarboxylic ketones, quinones can take part in addition reactions and reduction reactions. (chemicalbook.com)
  • Dr. Lantie Quinones, MD is a Addiction Psychiatry Specialist in Reston, VA. She has indicated that she accepts telehealth appointments. (healthgrades.com)
  • Use the Healthgrades insurance check to verify if Dr. Quinones accepts your insurance. (healthgrades.com)
  • When scavenging ROS, (-)-epicatechin will donate two electrons and become (-)-epicatechin quinone, and thus take over part of the oxidative potential of the ROS. (nih.gov)
  • The reaction of the para -quinone 6,7-dichloroquinoline-5,8-dione with various transition metal dimers led to the unexpected formation of quinoline- ortho -quinone metal complexes. (rsc.org)
  • The quinones are found in bacteria, in certain fungi, and in various higher plant forms, but in only a few animals. (britannica.com)
  • In a few quinones, the carbonyl groups are located in different rings. (britannica.com)
  • The unstable quinone methides afford stable alcoholic or carbonyl products. (mdpi.com)
  • These quinone imines are of toxicological significance since N-acetyl-p-benzoquinone imine is a postulated reactive intermediate formed during metabolism of the analgesic drug acetaminophen 1 while 4-(ethoxyphenyl)-p-benzoquinone imine is a possible reactive intermediate formed during metabolism of the analgesic phenacetin 2 . (springer.com)
  • Drawing on the investigative reporting that culminated in his book, Quinones lays out the recent history and economics of the growth in heroin and pain-killer usage and the lost lives along the way. (econtalk.org)
  • Their product is cheap and pure, and "Their job is to drive the city with their mouths full of little uninflated balloons of black tar heroin, twenty-five or thirty at a time in one mouth," Quinones writes. (themillions.com)
  • During his talk, Quinones will discuss the far-ranging causes of our nation's heroin and opioid epidemics. (cpl.org)
  • This is a national story-a nationwide problem that's debilitating for our country," Quinones says of the heroin and opioid epidemics. (cpl.org)
  • During his presentation, Quinones will address the complex range of factors that played a role in shaping today's epidemic: pharmaceutical marketing, pain management in America, shifts in the heroin market in recent decades, and how a deteriorating sense of community created what Quinones calls "a dangerous sense of isolation. (cpl.org)
  • Rosalie Quinones is a General Dentist practicing in SAN JUAN, PR. (dentalplans.com)
  • Rosselyn Quinones is a General Dentist practicing in PONCE, PR. (dentalplans.com)
  • Dr. Lizbeth Quinones, DDS is a Dentist primarily located in Miami, FL. (vitals.com)
  • When this reactivity is spread out over the entire molecule, i.e. over the AC-ring and B-ring, this will lead to partial epimerization of (-)-epicatechin quinone to (-)-catechin quinone. (nih.gov)
  • If there is no phenolic hydroxyl group in the molecule, quinones are nearly colorless. (chemicalbook.com)
  • Seven of the iron-sulfur clusters form a linear electron transfer chain between flavine and quinone. (nih.gov)
  • We show that oxidized forms of quinone electron carriers act as direct negative signals that inhibit autophosphorylation of ArcB during aerobiosis. (sciencemag.org)
  • Sam Quinones is a journalist, storyteller, former LA Times reporter, and author of three acclaimed books of narrative nonfiction. (samquinones.com)
  • Quinones, a Los Angeles-based journalist and public speaker, is also the author of Antonio's Gun and Delfino's Dream: True Tales of Mexican Migration and True Tales from Another Mexico: The Lynch Mob, the Popsicle Kings, Chalino and the Bronx . (cpl.org)
  • In this study we examined the metabolic fate of ortho -quinones derived from the catecholamine metabolites, 3,4-dihydroxyphenylethanol (DOPE), 3,4-dihydroxyphenylethylene glycol (DOPEG), 3,4-dihydroxyphenylacetic acid (DOPAC) and 3,4-dihydroxyphenylmandelic acid (DOMA). (mdpi.com)
  • Spectrophotometric examination showed that the ortho -quinones initially formed underwent extensive degradation at pH 6.8. (mdpi.com)
  • DOPAC-quinone and DOMA-quinone degraded immediately with decarboxylation of the ortho -quinone intermediates to form 3,4-dihydroxybenzylalcohol (DHBAlc) and 3,4-dihydroxybenzaldehyde (DHBAld), respectively. (mdpi.com)
  • The aim of the study is to determine where this chemical reactivity resides in (-)-epicatechin quinone. (nih.gov)
  • Therefore it can be concluded that the chemical reactivity of (-)-epicatechin quinone mainly resides in its B-ring. (nih.gov)
  • To detect the epimerization, the ability of ascorbate to reduce the unstable flavonoid quinones into the corresponding stable flavonoids was used. (nih.gov)
  • Sam Quinones is a reporter in Mexico City. (salon.com)
  • Albuquerque, NM - KUNM Capitol Reporter Manuel Quinones has more from Capitol Hill - where New Mexico Senators seem at odds with other border state lawmakers. (kunm.org)
  • KUNM Capitol Reporter Manuel Quinones explains. (kunm.org)
  • Sam Quinones , the Los Angeles Times reporter whose combination of compassion, clear-eyed realism, and graceful prose has made him a penetrating observer of immigration and border issues, spoke proudly today of his newspaper's commitment to covering the issue even at a time of severe economic stress at the paper (and at nearly every other metro daily in the country). (cis.org)
  • Xalisco wouldn't be noteworthy were it not a staging area for what Quinones - a former veteran L.A. Times reporter, who writes with clarity and confidence - describes as a "new kind of drug trafficking in America. (themillions.com)
  • Comics Book Review: Black Canary and Zatanna: Bloodspell by Paul Dini and Joe Quinones. (publishersweekly.com)
  • Quinone imines represent a class of biological reactive intermediates that has been the focus of intensive toxicological research in recent years. (springer.com)
  • Borrowed from the playbook of California cuisine, the layout places the focal point of cooking directly in the path of newly arrived guests, who inhale scents evocative of campfire and barbecue en route to their table. (atlantamagazine.com)
  • Quinones grew up in Claremont, California, and graduated from Claremont High School in 1977. (samquinones.com)
  • Dr. Maria Quinones, MD is a Doctor primarily located in West Hartford, CT . (vitals.com)
  • To summarize, the adjustability of the quinone formal potential as well as the fast charge transport in the bulk material ensures the applicability of the CRPs as electrode materials in organic batteries. (diva-portal.org)
  • After combined into glycosides, with the increased polarity, quinones can be easily dissolved in methanol, ethanol, and soluble in hot water, but slightly soluble in cold water, and almost insoluble in benzene, ether, chloroform and other non-polar organic solvents. (chemicalbook.com)
  • It's the one where actors play out some scene that poses a moral dilemma while the reaction of innocent bystanders is secretly recorded. Just when some unsuspecting citizen leaps in to save the day- or minds his own business and walks away- Quinones pops out for an interview. (dmagazine.com)
  • Our results suggest that quinone binding and chemistry play a key role in the coupling mechanism of complex I. (nature.com)
  • Benveniste EN (1997) Cytokines: influence on glial cell gene expression and function. (springer.com)
  • A series of quinone-pyrrole dyad polymers has been synthesized with a variety of quinone substituents, demonstrating the adjustability of quinone formal potentials by choice of substituents. (diva-portal.org)