Quinidine
An optical isomer of quinine, extracted from the bark of the CHINCHONA tree and similar plant species. This alkaloid dampens the excitability of cardiac and skeletal muscles by blocking sodium and potassium currents across cellular membranes. It prolongs cellular ACTION POTENTIALS, and decreases automaticity. Quinidine also blocks muscarinic and alpha-adrenergic neurotransmission.
Quinine
An alkaloid derived from the bark of the cinchona tree. It is used as an antimalarial drug, and is the active ingredient in extracts of the cinchona that have been used for that purpose since before 1633. Quinine is also a mild antipyretic and analgesic and has been used in common cold preparations for that purpose. It was used commonly and as a bitter and flavoring agent, and is still useful for the treatment of babesiosis. Quinine is also useful in some muscular disorders, especially nocturnal leg cramps and myotonia congenita, because of its direct effects on muscle membrane and sodium channels. The mechanisms of its antimalarial effects are not well understood.
Anti-Arrhythmia Agents
Agents used for the treatment or prevention of cardiac arrhythmias. They may affect the polarization-repolarization phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibers. Anti-arrhythmia agents are often classed into four main groups according to their mechanism of action: sodium channel blockade, beta-adrenergic blockade, repolarization prolongation, or calcium channel blockade.
Cytochrome P-450 CYP2D6
Disopyramide
Flecainide
Dextromethorphan
Methyl analog of DEXTRORPHAN that shows high affinity binding to several regions of the brain, including the medullary cough center. This compound is an NMDA receptor antagonist (RECEPTORS, N-METHYL-D-ASPARTATE) and acts as a non-competitive channel blocker. It is one of the widely used ANTITUSSIVES, and is also used to study the involvement of glutamate receptors in neurotoxicity.
Oxidoreductases, O-Demethylating
Propafenone
Sparteine
Debrisoquin
An adrenergic neuron-blocking drug similar in effects to GUANETHIDINE. It is also noteworthy in being a substrate for a polymorphic cytochrome P-450 enzyme. Persons with certain isoforms of this enzyme are unable to properly metabolize this and many other clinically important drugs. They are commonly referred to as having a debrisoquin 4-hydroxylase polymorphism.
Lidocaine
Pseudobulbar Palsy
A syndrome characterized by DYSARTHRIA, dysphagia, dysphonia, impairment of voluntary movements of tongue and facial muscles, and emotional lability. This condition is caused by diseases that affect the motor fibers that travel from the cerebral cortex to the lower BRAIN STEM (i.e., corticobulbar tracts); including MULTIPLE SCLEROSIS; MOTOR NEURON DISEASE; and CEREBROVASCULAR DISORDERS. (From Adams et al., Principles of Neurology, 6th ed, p489)
Encyclopedias as Topic
Cinchona
Dictionaries as Topic
Arrhythmias, Cardiac
Malaria
A protozoan disease caused in humans by four species of the PLASMODIUM genus: PLASMODIUM FALCIPARUM; PLASMODIUM VIVAX; PLASMODIUM OVALE; and PLASMODIUM MALARIAE; and transmitted by the bite of an infected female mosquito of the genus ANOPHELES. Malaria is endemic in parts of Asia, Africa, Central and South America, Oceania, and certain Caribbean islands. It is characterized by extreme exhaustion associated with paroxysms of high FEVER; SWEATING; shaking CHILLS; and ANEMIA. Malaria in ANIMALS is caused by other species of plasmodia.
Tablets
Biological Availability
Half-Life
Drug Labeling
Use of written, printed, or graphic materials upon or accompanying a drug container or wrapper. It includes contents, indications, effects, dosages, routes, methods, frequency and duration of administration, warnings, hazards, contraindications, side effects, precautions, and other relevant information.
Drug Repositioning
Product Labeling
United States Food and Drug Administration
Search Engine
Tachycardia, Supraventricular
Wolff-Parkinson-White Syndrome
A form of ventricular pre-excitation characterized by a short PR interval and a long QRS interval with a delta wave. In this syndrome, atrial impulses are abnormally conducted to the HEART VENTRICLES via an ACCESSORY CONDUCTING PATHWAY that is located between the wall of the right or left atria and the ventricles, also known as a BUNDLE OF KENT. The inherited form can be caused by mutation of PRKAG2 gene encoding a gamma-2 regulatory subunit of AMP-activated protein kinase.
Tachycardia, Atrioventricular Nodal Reentry
Abnormally rapid heartbeats caused by reentry of atrial impulse into the dual (fast and slow) pathways of ATRIOVENTRICULAR NODE. The common type involves a blocked atrial impulse in the slow pathway which reenters the fast pathway in a retrograde direction and simultaneously conducts to the atria and the ventricles leading to rapid HEART RATE of 150-250 beats per minute.
Atrial Flutter
Rapid, irregular atrial contractions caused by a block of electrical impulse conduction in the right atrium and a reentrant wave front traveling up the inter-atrial septum and down the right atrial free wall or vice versa. Unlike ATRIAL FIBRILLATION which is caused by abnormal impulse generation, typical atrial flutter is caused by abnormal impulse conduction. As in atrial fibrillation, patients with atrial flutter cannot effectively pump blood into the lower chambers of the heart (HEART VENTRICLES).
Catheter Ablation
Removal of tissue with electrical current delivered via electrodes positioned at the distal end of a catheter. Energy sources are commonly direct current (DC-shock) or alternating current at radiofrequencies (usually 750 kHz). The technique is used most often to ablate the AV junction and/or accessory pathways in order to interrupt AV conduction and produce AV block in the treatment of various tachyarrhythmias.
Formularies as Topic
Works about lists of drugs or collections of recipes, formulas, and prescriptions for the compounding of medicinal preparations. Formularies differ from PHARMACOPOEIAS in that they are less complete, lacking full descriptions of the drugs, their formulations, analytic composition, chemical properties, etc. In hospitals, formularies list all drugs commonly stocked in the hospital pharmacy.
Economics, Pharmaceutical
Economic aspects of the fields of pharmacy and pharmacology as they apply to the development and study of medical economics in rational drug therapy and the impact of pharmaceuticals on the cost of medical care. Pharmaceutical economics also includes the economic considerations of the pharmaceutical care delivery system and in drug prescribing, particularly of cost-benefit values. (From J Res Pharm Econ 1989;1(1); PharmacoEcon 1992;1(1))
Drug Industry
Academies and Institutes
Heart Diseases
Alkaloids
Malaria, Falciparum
Malaria caused by PLASMODIUM FALCIPARUM. This is the severest form of malaria and is associated with the highest levels of parasites in the blood. This disease is characterized by irregularly recurring febrile paroxysms that in extreme cases occur with acute cerebral, renal, or gastrointestinal manifestations.
Transport of fluid by lens epithelium. (1/618)
We report for the first time that cultured lens epithelial cell layers and rabbit lenses in vitro transport fluid. Layers of the alphaTN4 mouse cell line and bovine cell cultures were grown to confluence on permeable membrane inserts. Fluid movement across cultured layers and excised rabbit lenses was determined by volume clamp (37 degrees C). Cultured layers transported fluid from their basal to their apical sides against a pressure head of 3 cmH2O. Rates were (in microliter. h-1. cm-2) 3.3 +/- 0.3 for alphaTN4 cells (n = 27) and 4.7 +/- 1.0 for bovine layers (n = 6). Quinidine, a blocker of K+ channels, and p-chloromercuribenzenesulfonate and HgCl2, inhibitors of aquaporins, inhibited fluid transport. Rabbit lenses transported fluid from their anterior to their posterior sides against a 2.5-cmH2O pressure head at 10.3 +/- 0.62 microliter. h-1. lens-1 (n = 5) and along the same pressure head at 12.5 +/- 1.1 microliter. h-1. lens-1 (n = 6). We calculate that this flow could wash the lens extracellular space by convection about once every 2 h and therefore might contribute to lens homeostasis and transparency. (+info)Effects of dauricine, quinidine, and sotalol on action potential duration of papillary muscles in vitro. (2/618)
AIM: To compare the characteristics of dauricine, sotalol, and quinidine on action potential duration (APD). METHODS: Using intracellular microelectrode method to record APD in guinea pig papillary muscles. RESULTS: Dauricine 20 mumol.L-1 prolonged action potential at 90% repolarization, the percent of APD prolongation were 22 +/- 8, 11 +/- 6, 9 +/- 5, 7 +/- 5, 6 +/- 3, 4.3 +/- 2.8, 4.5 +/- 2.8 at the cycle lengths of 200-2000 ms, dauricine became more effective in lengthening APD at short cycle lengths. The effect of dauricine on prolonging APD exhibited normal use-dependence, whereas quinidine 1 mumol.L-1 and sotalol 10 mumol.L-1 were less effective in lengthening APD at short cycle lengths. The effect of quinidine and sotalol on APD exhibited reverse use-dependence. CONCLUSSION: The effect of dauricine on APD depends on activation frequency. (+info)In vitro metabolism of quinidine: the (3S)-3-hydroxylation of quinidine is a specific marker reaction for cytochrome P-4503A4 activity in human liver microsomes. (3/618)
The aim of this study was to evaluate the (3S)-3-hydroxylation and the N-oxidation of quinidine as biomarkers for cytochrome P-450 (CYP)3A4 activity in human liver microsome preparations. An HPLC method was developed to assay the metabolites (3S)-3-hydroxyquinidine (3-OH-Q) and quinidine N-oxide (Q-N-OX) formed during incubation with microsomes from human liver and from Saccharomyces cerevisiae strains expressing 10 human CYPs. 3-OH-Q formation complied with Michaelis-Menten kinetics (mean values of Vmax and Km: 74.4 nmol/mg/h and 74.2 microM, respectively). Q-N-OX formation followed two-site kinetics with mean values of Vmax, Km and Vmax/Km for the low affinity isozyme of 15.9 nmol/mg/h, 76.1 microM and 0.03 ml/mg/h, respectively. 3-OH-Q and Q-N-OX formations were potently inhibited by ketoconazole, itraconazole, and triacetyloleandomycin. Isozyme specific inhibitors of CYP1A2, -2C9, -2C19, -2D6, and -2E1 did not inhibit 3-OH-Q or Q-N-OX formation, with Ki values comparable with previously reported values. Statistically significant correlations were observed between CYP3A4 content and formations of 3-OH-Q and Q-N-OX in 12 human liver microsome preparations. Studies with yeast-expressed isozymes revealed that only CYP3A4 actively catalyzed the (3S)-3-hydroxylation. CYP3A4 was the most active enzyme in Q-N-OX formation, but CYP2C9 and 2E1 also catalyzed minor proportions of the N-oxidation. In conclusion, our studies demonstrate that only CYP3A4 is actively involved in the formation of 3-OH-Q. Hence, the (3S)-3-hydroxylation of quinidine is a specific probe for CYP3A4 activity in human liver microsome preparations, whereas the N-oxidation of quinidine is a somewhat less specific marker reaction for CYP3A4 activity, because the presence of a low affinity enzyme is demonstrated by different approaches. (+info)Pseudo second degree atrioventricular block with bradycardia. Successful treatment with quinidine. (4/618)
Pseudo second degree atrioventricular block resulting from blocked His premature beats was successfully treated with quinidine. The diagnosis was proved by His bundle electrogam which showed both blocked and conducted His premature beats. The blocked His prematures produced second degree atrioventricular block by making the atrioventricular junction refractory. Quinidine abolished both conducted and blocked His extrasystoles. There has been no recurrence of arrhythmia during a one-year follow-up. (+info)Novel membrane transporter OCTN1 mediates multispecific, bidirectional, and pH-dependent transport of organic cations. (5/618)
In the present study, functional characteristics of organic cation transporter (OCTN)1, which was cloned as the pH-dependent tetraethylammonium (TEA) transporter when expressed in mammalian human embryonic kidney (HEK)293 cells, were further investigated using Xenopus oocytes as well as HEK293 cells as gene expression systems. When OCTN1-derived complementary RNA was injected into Xenopus oocytes, pH-dependent transport of [14C]TEA was observed as the same in HEK293 cells. In contrast, a replacement of sodium ions with potassium ions in the surrounding medium did not cause any change in [14C]TEA uptake in Xenopus oocytes expressed with OCTN1. In addition, when OCTN1 was expressed in HEK293 cells, efflux of TEA from the cells was pH dependent, with an accelerated rate at acidic external medium pH. Accordingly, membrane potential or sodium ions are suggested to have no influence on [14C]TEA transport and the transport activity of OCTN1 is directly affected by pH itself. Furthermore, addition of the unlabeled TEA in external medium enhanced the efflux of preloaded [14C]TEA. These observations suggest that OCTN1 is a pH-dependent and bidirectional TEA transporter. OCTN1-mediated [14C]TEA uptake was inhibited by various organic cations such as cimetidine, procainamide, pyrilamine, quinidine, quinine, and verapamil. In addition, uptakes of cationic compounds such as [3H]pyrilamine, [3H]quinidine, and [3H]verapamil and zwitterionic L-[3H]carnitine were increased by expression of OCTN1 in Xenopus oocytes. Accordingly, OCTN1 was functionally demonstrated to be a multispecific and pH-dependent organic cation transporter, which presumably functions as a proton/organic cation antiporter at the renal apical membrane and other tissues. (+info)Effects of a novel cardioprotective drug, JTV-519, on membrane currents of guinea pig ventricular myocytes. (6/618)
We investigated effects of a novel cardioprotective drug, JTV-519 (4-[3-(4-benzylpiperidin-1-yl)propionyl]-7-methoxy-2,3,4,5-tetrahy dro-1,4-benzothiazepine monohydrochloride) on membrane currents of guinea pig ventricular myocytes by whole-cell voltage and current clamp methods. The fast Na+ current (iNa) was activated by ramp pulses from various holding potentials of -90, -80 or -60 mV to 10 mV with various intervals. At 0.2 Hz, JTV-519 inhibited iNa in a concentration-dependent manner with an IC50 of approximately 1.2 and 2 microM at the holding potential of -60 and -90 mM, respectively, implicating a voltage-dependent block. Increasing the pulse frequency from 1 to 2 or 3.3 Hz in the presence of 1 microM JTV-519 shortened the time-course and increased the level of iNa block, indicating a frequency-dependent block. The time-course of iNa blocking by JTV-519 was slower than that of lidocaine and similar to that of quinidine. Ca2+ current (iCa) and the inwardly rectifying K+ current (iK1) were also inhibited by JTV-519. JTV-519 decreased the duration and the height of the plateau of the action potential. We conclude that JTV-519 has frequency- and voltage-dependent blocking effects on iNa as well as inhibition of iCa and iK1. (+info)Alkalinization-induced K+ current of the mouse megakaryocyte. (7/618)
We have recently found that mouse megakaryocytes responded to extracellular alkalinization to pH > 8.0, generating a K+ current under voltage-clamped conditions with the whole cell recording mode of the patch-clamp technique. The purpose of this study was to physiologically and pharmacologically characterize the alkaline-dependent K+ conductance of the megakaryocyte membrane. The alkalinization-induced K+ current (I(ALK)) did not seem to be Ca2+-dependent since I(ALK) was allowed to be generated under intracellularly Ca2+-buffered conditions with 10 mM EGTA, which completely prevented the generation of caffeine-induced Ca2+-activated currents of mouse megakaryocytes; and no [Ca2+]i elevation was evoked by the alkalinization protocol in contrast to a significant increase in [Ca2+]i in response to caffeine when [Ca2+]i was measured with a fura 2 ratiometry. I(ALK) was strongly suppressed with tetraethylammonium (TEA), 4-aminopyridine (4-AP) and streptomycin (SM), but was completely resistant to quinidine (QND). The values of IC50 for the suppression of I(ALK) with TEA, 4-AP and SM were 5.6, 0.47 and 1.5 mM, respectively. Voltage-gated K+ currents (I(K)) of the same megakaryocyte preparation were weakly suppressed with TEA and 4-AP, while they were significantly suppressed with either SM or QND. These results suggest that mouse megakaryocytes possess K+ conductance that was activated by extracellular alkalinization and that probably differs from conventional K+ conductance in its pharmacological properties. (+info)Enhancing effects of salicylate on tonic and phasic block of Na+ channels by class 1 antiarrhythmic agents in the ventricular myocytes and the guinea pig papillary muscle. (8/618)
OBJECTIVE: To study the interaction between salicylate and class 1 antiarrhythmic agents. METHODS: The effects of salicylate on class 1 antiarrhythmic agent-induced tonic and phasic block of the Na+ current (INa) of ventricular myocytes and the upstroke velocity of the action potential (Vmax) of papillary muscles were examined by both the patch clamp technique and conventional microelectrode techniques. RESULTS: Salicylate enhanced quinidine-induced tonic and phasic block of INa at a holding potential of -100 mV but not at a holding potential of -140 mV; this enhancement was accompanied by a shift of the hinfinity curve in the presence of quinidine in a further hyperpolarized direction, although salicylate alone did not affect INa. Salicylate enhanced the tonic and phasic block of Vmax induced by quinidine, aprindine and disopyramide but had little effect on that induced by procainamide or mexiletine; the enhancing effects were related to the liposolubility of the drugs. CONCLUSIONS: Salicylate enhanced tonic and phasic block of Na+ channels induced by class 1 highly liposoluble antiarrhythmic agents. Based on the modulated receptor hypothesis, it is probable that this enhancement was mediated by an increase in the affinity of Na+ channel blockers with high lipid solubility to the inactivated state channels. (+info)
DailyMed - QUINIDINE SULFATE tablet
Quinidine sulfate United States Pharmacopeia (USP) Reference Standard | 6591-63-5 | Sigma-Aldrich
Quinidine - definition of quinidine by The Free Dictionary
Quinidine Lactate and Gluconate in the Suppression of Ectopic Ventricular Tachycardias Associated with Myocardial Infarction |...
Molecular analysis of a binding site for quinidine in a human cardiac delayed rectifier K+ channel. Role of S6 in...
NUEDEXTA (Quinidine sulfate,Dextromethorphan) dosage, indication, interactions, side effects | EMPR
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Pseudobulbar affect
... dextromethorphan hydrobromide 30 mg/quinidine sulfate 10 mg (N=110) Nuedexta - dextromethorphan hydrobromide 20 mg/quinidine ... Quinidine sulfate affects the way the heart beats, and is generally used in people with certain heart rhythm disorders. It is ... Dextromethorphan/quinidine is a combination of these two generic drugs, and is the first FDA-approved drug for the treatment of ... "Quinidine sulfate". PDRhealth™. 2016. Archived from the original on 2015-09-05. Retrieved 2016-02-18. "Label: NUEDEXTA- ...
Brugada syndrome
Quinidine is an antiarrhythmic drug that may reduce the chance of serious abnormal heart rhythms occurring in some people with ... Yang F, Hanon S, Lam P, Schweitzer P (April 2009). "Quinidine revisited". The American Journal of Medicine. 122 (4): 317-21. ... Belhassen B, Glick A, Viskin S (September 2004). "Efficacy of quinidine in high-risk patients with Brugada syndrome". ... while quinidine may be used longer term. Testing people's family members may be recommended. The condition affects between 1 ...
Quinine
... (and quinidine) are used as the chiral moiety for the ligands used in Sharpless asymmetric dihydroxylation as well as ... No injectable preparation of quinine is licensed in the US; quinidine is used instead. Quinine is a flavor component of tonic ... Centers for Disease Control and Prevention (April 1991). "Treatment with quinidine gluconate of persons with severe Plasmodium ... September 2005). "Effects of quinine, quinidine, and chloroquine on alpha9alpha10 nicotinic cholinergic receptors". Molecular ...
Ritonavir
... quinidine;[medical citation needed] ranolazine;[medical citation needed] salmeterol;[medical citation needed] saquinavir- ...
Disopyramide
... 's Class 1a activity is similar to that of quinidine in that it targets sodium channels to inhibit conduction. ... Quinidine, procainamide and disopyramide". Drug Safety. 5 (6): 393-420. doi:10.2165/00002018-199005060-00002. PMID 2285495. ... "Effects of intravenous disopyramide and quinidine on normal myocardium and on the characteristics of arrhythmias: ...
Encainide
"Lysergic acid and quinidine analogs. 2-(o-Acylaminophenethyl)piperidines". Journal of Medicinal Chemistry. 16 (9): 1015-20. doi ...
Category:Alkene derivatives
Text is available under the Creative Commons Attribution-ShareAlike License; additional terms may apply. By using this site, you agree to the Terms of Use and Privacy Policy. Wikipedia® is a registered trademark of the Wikimedia Foundation, Inc., a non-profit organization ...
Alkaloid
... quinidine), analgesic (e.g. morphine),[10] antibacterial (e.g. chelerythrine),[11] and antihyperglycemic activities (e.g. ...
Antimalarial medication
Quinimax and quinidine are the two most commonly used alkaloids related to quinine in the treatment or prevention of malaria. ... Quinidine is a direct derivative of quinine. It is a distereoisomer, thus having similar anti-malarial properties to the parent ... Quinidine is recommended only for the treatment of severe cases of malaria. Warburg's tincture was a febrifuge developed by ... Quinimax is a combination of four alkaloids (quinine, quinidine, cinchoine and cinchonidine). This combination has been shown ...
Schedule H
QUINIDINE SULPHATE 423. RABEPRAZOLE 424. RACECADOTRIL 425. RALOXIFENE HYDROCHLORIDE 426. RAMIPRIL HYDROCHLORIDE ...
Trihexyphenidyl
Quinidine : Increased anticholinergic action (particular on AV conduction). Antipsychotics : Long term use of trihexyphenidyl ...
Sodium channel blocker
While procainamide and quinidine may be used in the conversion of atrial fibrillation to normal sinus rhythm, they should only ... Class Ia agents include quinidine, procainamide and disopyramide. Class Ib antiarrhythmic agents are sodium channel blockers. ... because procainamide and quinidine can increase the conduction through the AV node and may cause 1:1 conduction of atrial ...
Chlorpromazine
Quinidine may interact with chlorpromazine to increase myocardialdepression. Likewise it may also antagonize the effects of ... Other drugs that prolong the QT interval such as quinidine, verapamil, amiodarone, sotalol and methadone may also interact with ...
Tetrandrine
It has a quinidine-like anti-arrhythmic effect. It is isolated from the plant Stephania tetrandra, and other Chinese and ...
Cardioversion
Procainamide, quinidine and disopyramide are Class Ia agents. Class 1b drugs lengthen phase 3 repolarization. They include ...
Cinchona
Two more key alkaloids, quinidine and cinchonidine, were later identified and it became a routine in quinology to examine the ... The bark contains alkaloids, including quinine and quinidine. Cinchona is the only economically practical source of quinine, a ... Cinchona alkaloids include: cinchonine and cinchonidine (stereoisomers with R1 = vinyl, R2 = hydrogen) quinine and quinidine ( ...
Loperamide
... taken with quinidine was found to produce respiratory depression, indicative of central opioid action. Loperamide ... Concurrent administration of P-glycoprotein inhibitors such as quinidine potentially allows loperamide to cross the blood-brain ... Common P-glycoprotein inhibitors include quinidine, ritonavir, and ketoconazole. Loperamide is capable of decreasing the ...
Amikacin
Quinidine also increases levels of amikacin in the body. The NSAID indomethacin can increase serum aminoglycoside levels in ...
Dextrorphan
Relevance to dextromethorphan/quinidine (Nuedexta®) clinical use". Pharmacol. Ther. 164: 170-82. doi:10.1016/j.pharmthera. ...
Procainamide
Due to the loss of Indonesia in World War II, the source for cinchona alkaloids, a precursor of quinidine, was reduced. This ... As a result, procaine was discovered, which has similar cardiac effects as quinidine. In 1936 it was found by Mautz that by ... These were the cardiac glycosides, quinidine, propranolol, lidocaine and diphenylhydantoin. In January 1996, extended release ... but it had the same toxicity profile as quinidine, and it could cause systemic lupus erythematosus-like syndrome. These ...
Deep hypothermic circulatory arrest
Woodhall B, Sealy WC, Hall KD, Floyd WL (July 1960). "Craniotomy under conditions of quinidine-protected cardioplegia and ... Woodhall B, Sealy WC, Hall KD, Floyd WL (July 1960). "Craniotomy under conditions of quinidine-protected cardioplegia and ... Woodhall B, Sealy WC, Hall KD, Floyd WL (July 1960). "Craniotomy under conditions of quinidine-protected cardioplegia and ...
Acetazolamide
Quinidine, reduces urinary excretion of quinidine, hence increasing the potential for toxicity. Salicylates, potential for ...
Amaurosis
Quinidine toxicity can lead to cinchonism and also to quinine amaurosis.[citation needed] Those experiencing amaurosis are ...
Cinchona officinalis
Other alkaloids that are extracted from this tree include cinchonine, cinchonidine and quinidine. Standley, Paul C. (1936). " ...
Potassium channel blocker
Drugs such as quinidine may be both reverse use dependent and use dependent. Examples of calcium-activated channel blockers ... Reverse use dependent drugs that slow heart rate (such as quinidine) can be less effective at high heart rates. The ... such as quinidine) are more efficacious at preventing a tachyarrhythmia than converting someone into normal sinus rhythm.[ ... Bupivacaine Quinidine Fluoxetine Seproxetine (Norfluoxetine) 12-O-tetradecanoylphorbol-13-acetate (TPA) (phorbol 12-myristate ...
Porphyria cutanea tarda
Protoporphyrin IX Complexes of the Antimalarial Cinchona Alkaloids Quinine and Quinidine". ACS Chemical Biology. 7 (4): 666-71 ...
Pindolol
... shows membrane-stabilizing effects like quinidine, possibly accounting for its antiarrhythmic effects. It also acts as ...
Fluconazole
... concomitant administration of fluconazole and quinidine, especially when fluconazole is administered in high dosages; take ...
Quinidine: MedlinePlus Drug Information
Quinidine: learn about side effects, dosage, special precautions, and more on MedlinePlus ... Quinidine comes as a tablet (quinidine sulfate) and an extended-release (long-acting) tablet (quinidine gluconate) to take by ... Quinidine helps control your condition but will not cure it. Continue to take quinidine even if you feel well. Do not stop ... Before taking quinidine,. *tell your doctor and pharmacist if you are allergic to quinidine, quinine, or any other drugs. ...
Dextromethorphan and Quinidine: MedlinePlus Drug Information
Dextromethorphan and Quinidine: learn about side effects, dosage, special precautions, and more on MedlinePlus ... Quinidine is in a class of medications called antiarrhythmics. When combined with dextromethorphan, quinidine works by ... Take dextromethorphan and quinidine at around the same time(s) every day. Follow the directions on your prescription label ... Take the combination of dextromethorphan and quinidine exactly as directed. Do not take more or less of it or take it more ...
CDC - Malaria - Quinidine Availability in the United States
The pharmaceutical manufacturer of quinidine, Eli Lilly, recently announcedExternal. that it will no longer be producing IV ... As of today, intravenous quinidine gluconate remains available for the treatment of severe malaria. CDC and FDA are developing ... quinidine gluconate, but plans to continue distributing the product until the current stock expires (March 2019). ...
Quinidine Oral
Quinidine comes as a tablet to take by mouth. Immediate-acting quinidine usually is taken three or four times a day. The ... Quinidine helps control your condition but will not cure it. Continue to take quinidine even if you feel well. Do not stop ... Take quinidine at the same time each day in regularly spaced intervals. Changing the time of your doses prevents quinidine from ... Quinidine is used to treat abnormal heart rhythms. It works by making your heart more resistant to abnormal activity. Quinidine ...
Quinidine - Wikipedia
Quinidine sulfate is used in the treatment of atrial fibrillation in horses. Grace AA, Camm AJ (1998). "Quinidine". N. Engl. J ... Quinidine is also used to treat short QT syndrome. Eli Lilly has discontinued manufacture of parenteral quinidine gluconate in ... Quinidine is a medication that acts as a class I antiarrhythmic agent (Ia) in the heart. It is a stereoisomer of quinine, ... The dose of quinidine (10mg two times daily) is about 1/40th of a relatively low antiarrythmic dose (400mg, twice or 3 times ...
Quinidine - definition of quinidine by The Free Dictionary
quinidine synonyms, quinidine pronunciation, quinidine translation, English dictionary definition of quinidine. n. A bitter ... quinidine. Also found in: Thesaurus, Medical, Encyclopedia, Wikipedia.. Related to quinidine: quinine, Quinidine sulfate quin·i ... Quinidine - definition of quinidine by The Free Dictionary https://www.thefreedictionary.com/quinidine ... quinidine. (ˈkwɪnɪˌdiːn) n. (Pharmacology) a crystalline alkaloid drug that is an optically active diastereoisomer of quinine: ...
DailyMed - QUINIDINE SULFATE tablet
... equivalent to 166 mg of quinidine base) 300 mg of quinidine sulfate (equivalent to 249 mg of quinidine base). In addition, each ... Non-interactions of quinidine with other drugs Quinidine has no clinically significant effect on the pharmacokinetics of ... Quinidine-induced hypotension that is not due to an arrhythmia is likely to be a consequence of quinidine-related α-blockade ... Therapy with quinidine sulfate should be begun with 200 mg (equivalent to 166 mg of quinidine base) every six hours. If this ...
Interactions between Eryped 200 Oral and azithromycinerythromycintroleandomycin-quinidine-quinine
WebMD provides information about interactions between Eryped 200 Oral and azithromycinerythromycintroleandomycin-quinidine- ... The amount of quinidine or quinine in your blood may increase and cause serious side effects, such as an irregular heartbeat. ... Quinidine; Quinine/Azithromycin; Erythromycin; Troleandomycin Interactions. This information is generalized and not intended as ... Possible inhibition of hepatic metabolism of quinidine by erythromycin. Clin Pharmacol Ther 1995 Jan;57(1):89-94. ...
Quinidine - brand name list from Drugs.com
Find information on quinidine use, treatment, drug class and molecular formula. ... Lists the various brand names available for medicines containing quinidine. ... Product(s) containing quinidine:. quinidine systemic. Brand names: Cardioquin, Quinora, Quinidex Extentabs, Quinaglute Dura- ... Quinidine. Important: The information below refers to products available in the United States that contain quinidine. ...
Quinidine dictionary definition | quinidine defined
quinidine definition: a colorless, crystalline alkaloid, CHNO, isomeric with and resembling quinine, extracted from cinchona ... quinidine. noun. A bitter alkaloid, C20H24N2O2, that is a stereoisomer of quinine, used in the form of its salts to treat ... quinidine. quin·i·dine. a colorless, crystalline alkaloid, CHNO, isomeric with and resembling quinine, extracted from cinchona ... The sulphate of quinine used in medicine may contain up to 3% of cinchonidine, but should be free from cinchonine, quinidine ...
Interactions between Desipramine Oral and selected-tricyclic-antidepressants-quinidine-thioridazine
WebMD provides information about interactions between Desipramine Oral and selected-tricyclic-antidepressants-quinidine- ... Quinidine or thioridazine may slow down how quickly your body processes medicines in the tricyclic antidepressant family: ... Selected Tricyclic Antidepressants/Quinidine; Thioridazine Interactions. This information is generalized and not intended as ... 9.Nuedexta (dextromethorphan hydrobromide and quinidine sulfate) US prescribing information. Avanir Pharmaceuticals January, ...
Dextromethorphan/quinidine Side Effects in Detail - Drugs.com
Learn about the potential side effects of dextromethorphan/quinidine. Includes common and rare side effects information for ... Applies to dextromethorphan/quinidine: oral capsule. Along with its needed effects, dextromethorphan / quinidine may cause some ... Get emergency help immediately if any of the following symptoms of overdose occur while taking dextromethorphan / quinidine: ... Applies to dextromethorphan / quinidine: oral capsule. General. The most commonly reported adverse reactions (2% or greater ...
Dextromethorphan And Quinidine (Oral Route) Precautions - Mayo Clinic
Quinidex (Quinidine): Uses, Dosage, Side Effects, Interactions, Warning
Quinidine) may treat, side effects, dosage, drug interactions, warnings, patient labeling, reviews, and related medications ... Non-interactions of quinidine with other drugs: Quinidine has no clinically significant effect on the pharmacokinetics of ... Non-interactions of quinidine with other drugs: Quinidine has no clinically significant effect on the pharmacokinetics of ... Quinidine is not metabolized by cytochrome P 450 IID 6 , but therapeutic serum levels of quinidine inhibit the action of ...
Dextromethorphan and Quinidine | Memorial Sloan Kettering Cancer Center
DailyMed - Search Results for QUINIDINE SULFATE
QUINIDINE SULFATE tablet. NDC Code(s): 0185-1047-01, 0185-1047-10, 0185-4346-01, 0185-4346-10 *Packager: Eon Labs, Inc. ... QUINIDINE SULFATE tablet. NDC Code(s): 68151-1991-0 *Packager: Carilion Materials Management ... NUEDEXTA (dextromethorphan hydrobromide and quinidine sulfate) capsule, gelatin coated. NDC Code(s): 64597-301-13, 64597-301-60 ...
007831: Quinidine, Serum or Plasma | LabCorp
Peak: quinidine sulfate: 11/2 hours after dose, quinidine gluconate: four hours after dose; trough: immediately prior to next ... Doses of quinidine ,250 mg/day result in increased serum digoxin concentrations about 2.5 times the digoxin concentration ... Quinidine is often preferred to procainamide for long-term therapy because elevated antinuclear antibody titers and drug- ... Quinidine also has been used to prevent symptomatic premature supraventricular and ventricular complexes. Because it slows ...
Quinidine - Registration Dossier - ECHA
In consequence, quinidine can not be considered as flammable.. Key value for chemical safety assessment. Flammability:. non ... During the test quinidine gluconate and quinine shortly burns and rapidly extinguish. Consequently, further testing is not ... Quinidine gluconate and quinine are short burning and a rapid extinguishing (BZ2) during the preliminary test. ... The test showed that quinidine shortly burns and rapidly extinguish, so that further testing is not necessary according to ...
Quinidine crystallized, ≥98.0% (dried material, NT) | Sigma-Aldrich
Quinidine crystallized, ,=98.0% (dried material, NT); CAS Number: 56-54-2; Linear Formula: C20H24N2O2; find related products, ... Quinidine is an isomer of quinine. Application Quinidine may be used in the preparation of O-trimethylsilylquinidine by ... HPLC Analysis of Quinidine and Trace Impurity on Discovery® HS F5 From our library of Articles, Sigma-Aldrich presents HPLC ... UHPLC Analysis of Quinidine and Metabolite on Titan™ C18 From our library of Articles, Sigma-Aldrich presents UHPLC Analysis of ...
Quinidine injection | StayWell Health Library | Main
Quinidine injection What is this medicine? QUINIDINE (KWIN i deen) is an antiarrhythmic drug. It helps make your heart beat ... Quinidine injection. What is this medicine?. QUINIDINE (KWIN i deen) is an antiarrhythmic drug. It helps make your heart beat ... an unusual or allergic reaction to quinidine, quinine, other medicines, foods, dyes, or preservatives ...
Notice to Readers
Availability of Parenteral Quinidine Gluconate for Treatment of
Severe or Complicated Malaria
Since 1991, quinidine gluconate, a well-known and widely used class Ia anti-arrhythmic agent, has been the only parenteral ... Intravenous quinidine is indicated whenever oral therapy is not possible, in high-density infections (greater than 5% of red ... Notice to Readers Availability of Parenteral Quinidine Gluconate for Treatment of Severe or Complicated Malaria CDC has ... As newer anti-arrhythmic agents have replaced quinidine for many of its cardiac indications, some hospitals and health ...
Browsing by Subject "Quinidine"
quinidine - definition and meaning
quinidine: A colorless crystalline alkaloid, C20H24N2O2, resembling quinine and used in treating malaria and certain heart ... What we have done is recognized that you can inhibit ones ability to metabolize dextromethorphan by adding quinidine, which is ... You could consider changing the way you are delivering quinidine which is your 2D6 inhibitor, you could consider looking at ... Quinine, a famous malaria treatment, and quinidine, an antiarrhythmic medication, are made from the bark of the cinchona tree. ...
Quinidine Sulfate 10 mg/mL Oral Suspension
... Loyd V. Allen, Jr., PhD. Professor Emeritus. College of Pharmacy, University of ... The oral suspension USP contains 90.0% to 110.0% of the labeled amount of quinidine sulfate (C20H24N2O2)2.H2SO4.2H2O. The pH of ... Discussion: Quinidine sulfate ([C20H24N2O2]2.H2SO4.2H2O, MW 782.94) occurs as fine, needlelike, white crystals frequently ... Crush the tablets to a fine powder or use the quinidine sulfate powder. Add about 25 mL of Ora-Plus, and mix to form a smooth ...
Absorption of quinidine and dihydroquinidine in humans.
In all subjects, dihydroquinidine was absorbed to a lesser extent than quinidine. On the basis of comparative AUC pu to 6 h ... Quinidine and dihydroquinidine were administered as the sulphates in an oral solution to seven healthy volunteers. ... Quinidine and dihydroquinidine were administered as the sulphates in an oral solution to seven healthy volunteers. In all ... 0/Drug Combinations; 1435-55-8/hydroquinidine; 56-54-2/Quinidine From MEDLINE®/PubMed®, a database of the U.S. National Library ...
Quinidine | Springer for Research & Development
dextromethorphan and quinidine - WellSpan Health Library
Quinidine affects the way that the heart beats and is generally used in people with certain heart rhythm disorders. ... Dextromethorphan and quinidine is a combination medicine used to treat involuntary... ... if you are also taking mefloquine, quinidine, or quinine.. Do not use dextromethorphan and quinidine if you have used an MAO ... You also should not take dextromethorphan and quinidine if you are also taking mefloquine, quinidine, or quinine, or if you ...
Digoxin-Quinidine Interaction | Annals of Internal Medicine | American College of Physicians
Digoxin-Quinidine Interaction J. ROBERT POWELL, PHARM.D.; PAUL E. FENSTER, M.D.; W. DAVID HAGER, M.D. ... To the editor: Mungall and associates (1) presented data which quantitate both the time course of the digoxin-quinidine ... Digoxin-Quinidine Interaction. Ann Intern Med. ;94:540. doi: 10.7326/0003-4819-94-4-540_1 ... achieve near steady state 6 days after starting quinidine therapy and that digoxin renal clearance is reduced by quinidine. We ...
Possible inhibition of hepatic metabolism of quinidine by erythromycin.
To present and analyze a patient case illustrating a possible drug interaction between quinidine and erythromycin. METHODS: ... an increase in quinidine serum concentrations, and a possible quinidine toxicity. CONCLUSION: Serum quinidine concentrations, ... This case demonstrated a probable erythromycin-quinidine pharmacokinetic interaction that led to a decrease in quinidine ... OBJECTIVE: To present and analyze a patient case illustrating a possible drug interaction between quinidine and erythromycin. ...
Quinidine-lnduced Lupus Erythematosus | Annals of Internal Medicine | American College of Physicians
... after 5 months of quinidine therapy). Quinidine-induced antinuclear autoantibodies were of the IgM and IgG classes and were ... Quinidine-lnduced Lupus Erythematosus STERLING G. WEST, M.D.; MATTHEW McMAHON, D.O.; JOSEPH P. PORTANOVA, Ph.D. ... Upon withdrawal of quinidine therapy, the patient had prompt improvement of clinical symptoms followed by a gradual resolution ... Quinidine-lnduced Lupus Erythematosus. Ann Intern Med. 1984;100:840-842. doi: 10.7326/0003-4819-100-6-840 ...
GluconateEffects of quinidineMefloquineNuedextaQuinidexDigoxinArrhythmiasMalariaConcentrationsDosageCombination of dextromethorphanToxicityKwinInhibitsDose of quinidineDavis's Drug GuideEffect of quinidineQuinine and quinidineDextromethorphan hydrobromide and quinidine sulfateTabletsAlkaloidOral quinidineTherapeuticDosesSide effects of dextromethorphanInteract with dextromethorphan and quinidineThrombocytopeniaPharmacokineticsTorsades de poinIsomer of quinine10mgAntiarrhythmic drugsSerum quinidine concentrationAntibodies recognize quinidineCombined with dextromethorphanConcentration and quinidineDrugsAtrial fibrillationAutomaticityAntiarrhythmicsForm of quinidineIncrease in quinidineMetabolism of quinidineInteraction of quinidineElimination of quinidinePseudobulbarAntigenInhibitionSodiumGrapefruit juiceConductionCYP2D6AntimalarialTake quinidine
Gluconate20
- Quinidine comes as a tablet (quinidine sulfate) and an extended-release (long-acting) tablet (quinidine gluconate) to take by mouth. (medlineplus.gov)
- Extended-release quinidine gluconate tablets are usually is taken every 8 to 12 hours. (medlineplus.gov)
- Eli Lilly has discontinued manufacture of parenteral quinidine gluconate in the US, and its future availability in many countries is uncertain. (wikipedia.org)
- The pharmaceutical manufacturer of quinidine, Eli Lilly, recently announced External that it will no longer be producing IV quinidine gluconate, but plans to continue distributing the product until the current stock expires (March 2019). (cdc.gov)
- As of today, intravenous quinidine gluconate remains available for the treatment of severe malaria. (cdc.gov)
- Quinidine gluconate and quinine are short burning and a rapid extinguishing (BZ2) during the preliminary test. (europa.eu)
- According to the study report the flammability of quinidine gluconate and quinine were experimentally determined similar to the preliminary testing according to regulation 440/2008. (europa.eu)
- During the test quinidine gluconate and quinine shortly burns and rapidly extinguish. (europa.eu)
- CDC has received reports of two fatal cases of Plasmodium falciparum malaria in the United States in which a delay in obtaining quinidine gluconate for intravenous therapy was thought to have played a role in the patients' deaths. (cdc.gov)
- Since 1991, quinidine gluconate, a well-known and widely used class Ia anti-arrhythmic agent, has been the only parenteral antimalarial drug available in the United States. (cdc.gov)
- As newer anti-arrhythmic agents have replaced quinidine for many of its cardiac indications, some hospitals and health facilities have dropped quinidine gluconate from their formularies. (cdc.gov)
- Because of this potential problem, directors of hospital drug services should take into account the essential role of quinidine gluconate in treating patients with severe and complicated malaria before removing it from their formularies. (cdc.gov)
- Intravenous quinidine lactate and quinidine gluconate effectively control the arrhythmia in 56 to 60 per cent of the animals, but produce toxic reactions in many of them. (ahajournals.org)
- The most effective treatment of the arrhythmia was by use of morphine followed by quinidine gluconate. (ahajournals.org)
- If sinus rhythm isn't restored after patient has received a total of 10 mg/kg quinidine gluconate, other means of cardioversion may be considered. (thefreedictionary.com)
- Know that quinidine gluconate is the only parenteral cinchona alkaloid antimalarial commercially available in U.S. Because newer antiarrhythmics have replaced quinidine in many cardiac uses, it may not be readily available and prescribers may not be familiar with its use. (thefreedictionary.com)
- The last during one i went to only he gave me quinidine gluconate and netupitant. (gonzoz.com)
- Each Quinidine gluconate for inj 80mg/ml usp 250 microgram tablet contains 250 micrograms instead of the active ingredient quinidine. (gonzoz.com)
- Extended-release quinidine gluconate (stars with dotted line) and quinidine sulfate (squares with solid line) have slower absorption profiles, so the drug has an opportunity to distribute to tissues while absorption is occurring. (mhmedical.com)
- Quinidine is available either as quinidine sulfate or quinidine gluconate. (medicalproductguide.com)
Effects of quinidine10
- Because of the proarrhythmic effects of quinidine, its use with ventricular arrhythmias of lesser severity is generally not recommended, and treatment of patients with asymptomatic ventricular premature contractions should be avoided. (rxlist.com)
- Our research demonstrated stereoselective effects of quinidine and quinine on the hERG channel, and this is the first study to explore their reversal potency on drug-induced hERG deficiency. (mdpi.com)
- Common side effects of quinidine include diarrhea, lightheadedness, and headache. (rxwiki.com)
- This study examined the effects of quinidine, quinine, and the quaternary quinidine derivative, quinidinium, on the conductance and activity of purified cardiac sarcoplasmic reticulum calcium release channels/ryanodine receptors (RyR) incorporated into planar lipid bilayers. (aspetjournals.org)
- There was no stereospecificity in the effects of quinidine because the levoisomer, 100 μM quinine, produced a similar subconductance activity of the channel. (aspetjournals.org)
- This dependency may explain why hypokalemic patients are often unresponsive to the antiarrhythmic effects of quinidine and are prone to develop cardiac rhythm disorders. (brainkart.com)
- The depressant effects of quinidine on the cardiovascular system are most likely to occur after IV administration, and therefore, quinidine should not be employed rou-tinely in the emergency treatment of arrhythmias. (brainkart.com)
- Effects of quinidine and lidocaine on myocardial conduction. (semanticscholar.org)
- The effects of quinidine and lidocaine on the maximum upstroke velocity (Vmax) of the ventricular myocardial action potential were compared with the effects predicted by a model over a wide range of driving rates, rhythm disturbances and holding potentials. (semanticscholar.org)
- Effects of quinidine on the sodium current of guinea pig ventricular myocytes. (semanticscholar.org)
Mefloquine9
- tell your doctor and pharmacist if you are allergic to dextromethorphan, quinidine (Quinidex), quinine (Qualaquin), mefloquine (Lariam), any other medications, or any of the ingredients in combination dextromethorphan and quinidine capsules. (medlineplus.gov)
- tell your doctor if you are taking mefloquine (Lariam), pimozide (Orap), quinine (Qualaquin) thioridazine, or or another product containing quinidine (Quinidex). (medlineplus.gov)
- tell your doctor if you have or have ever had the following conditions while taking quinidine, quinine, or mefloquine: decrease in the number of blood cells in your bone marrow, lupus (a condition in which the body attacks its own tissues causing damage and swelling), or hepatitis (swelling of the liver). (medlineplus.gov)
- If you have ever had any of these health problems when taking this drug, mefloquine, quinidine, or quinine: Bone marrow problems, hepatitis, low platelet count, or lupus. (mskcc.org)
- If you are taking any of these drugs: Mefloquine, quinidine, or quinine. (mskcc.org)
- You also should not take dextromethorphan and quinidine if you are also taking mefloquine, quinidine, or quinine, or if you have ever had an allergic reaction or serious medical problem caused by taking any of these medications. (wellspan.org)
- if you are also taking mefloquine, quinidine, or quinine. (wellspan.org)
- Do not use this medicine if you have a history of bone marrow problems, hepatitis, lupus-like syndrome, or thrombocytopenia (low platelets in the blood) caused by quinidine, quinine, or mefloquine. (limamemorial.org)
- Concomitant quinidine, quinine, or mefloquine. (oncologynurseadvisor.com)
Nuedexta2
Quinidex10
- In patients with symptomatic atrial fibrillation/flutter whose symptoms are not adequately controlled by measures that reduce the rate of ventricular response, Quinidex (quinidine) is indicated as a means of restoring normal sinus rhythm . (rxlist.com)
- If this use of Quinidex (quinidine) does not restore sinus rhythm within a reasonable time (see DOSAGE AND ADMINISTRATION ), then Quinidex (quinidine) should be discontinued. (rxlist.com)
- Quinidex (quinidine) should be used only after alternative measures (e.g., use of other drugs to control ventricular rate) have been found to be inadequate. (rxlist.com)
- Quinidex (quinidine) is also indicated for the suppression of recurrent documented ventricular arrhythmias, such as sustained ventricular tachycardia , that in the judgment of the physician are life-threatening. (rxlist.com)
- Antiarrhythmic drugs (including Quinidex (quinidine) ) have not been shown to enhance survival in patients with ventricular arrhythmias. (rxlist.com)
- Especially in patients with known structural heart disease or other risk factors for toxicity , initiation or dose-adjustment of treatment with Quinidex (quinidine) should generally be performed in a setting where facilities and personnel for monitoring and resuscitation are continuously available. (rxlist.com)
- Patients with symptomatic atrial fibrillation/flutter should be treated with Quinidex (quinidine) only after ventricular rate control (e.g., with digitalis or (beta)-blockers) has failed to provide satisfactory control of symptoms. (rxlist.com)
- Adequate trials have not identified an optimal regimen of Quinidex (quinidine) for conversion of atrial fibrillation/flutter to sinus rhythm. (rxlist.com)
- or the patient develops significant tachycardia , symptomatic bradycardia , or hypotension , then Quinidex (quinidine) is discontinued, and other means of conversion (e.g., direct-current cardioversion ) are considered. (rxlist.com)
- Quinidine ( Quinidex ) was one of the first clinically used antiarrhythmic agents. (brainkart.com)
Digoxin13
- 250 mg/day result in increased serum digoxin concentrations about 2.5 times the digoxin concentration before quinidine was added. (labcorp.com)
- The new steady-state of digoxin concentration occurs in 7 to 14 days, with signs of toxicity beginning to appear in three to seven days after initiation of quinidine therapy. (labcorp.com)
- Therefore, serum digoxin concentrations should be measured before initiation of quinidine therapy and again in four to six days. (labcorp.com)
- Generic pharmaceuticals are not new since even before 1965 several products appeared on the market such as phenobarbitol, digoxin, quinidine , and many others and nobody paid much attention to them. (wordnik.com)
- To the editor: Mungall and associates (1) presented data which quantitate both the time course of the digoxin-quinidine interaction, and the magnitude of change in digoxin renal clearance induced by quinidine. (annals.org)
- We (2) and others (3) agree with the conclusions by Mungall and associates that digoxin levels achieve near steady state 6 days after starting quinidine therapy and that digoxin renal clearance is reduced by quinidine. (annals.org)
- If patient has atrial fibrillation, expect to give digoxin, calcium channel blocker, beta-adrenergic blocker, and possibly an anticoagulant before administering quinidine. (thefreedictionary.com)
- The interactions between digoxin and quinine and quinidine that affect the renal and biliary clearances of digoxin were investigated in eight healthy subjects. (nih.gov)
- In four of the subjects, the study was repeated by administration of equimolar doses of the diastereoisomer quinidine together with digoxin, enabling a within-subject comparison of the effects of the two isomers on digoxin clearance. (nih.gov)
- These findings explain the difference in magnitude between quinidine and quinine in regard to the interaction with digoxin and imply a different degree of stereoselectivity for these isomers in the renal and biliary secretory systems of digoxin. (nih.gov)
- Digoxin levels may be increased by quinidine. (vetstream.com)
- It is recommended that the dose of digoxin be decreased by 1/2 when adding quinidine and that serum drug levels of both quinidine and digoxin be assessed. (vetstream.com)
- Control the ventricular rate and CHF (if present) with digoxin or calcium channel blockers before the administration of quinidine. (medscape.com)
Arrhythmias8
- Quinidine may increase the chance of having arrhythmias (irregular heartbeats) and has not been proven to help people without life-threatening arrhythmias to live longer. (medlineplus.gov)
- Quinidine is occasionally used as a class I antiarrhythmic agent to prevent ventricular arrhythmias, particularly in Brugada Syndrome, although its safety in this indication is uncertain. (wikipedia.org)
- Quinidine usually is used only to treat life-threatening arrhythmias. (empowher.com)
- if these arrhythmias develop, they should be treated as one would treat a quinidine overdose. (wordnik.com)
- Quinidine has proarrhythmic properties and may induce or worsen cardiac arrhythmias. (pdr.net)
- Quinidine has been associated with increased mortality when used to treat various arrhythmias. (pdr.net)
- Genetically determined steady-state interaction between encainide and quinidine in patients with arrhythmias. (aspetjournals.org)
- Quinidine serum concentrations above the therapeutic range can cause increased QT interval or QRS complex widening (>35%-50%) on the electrocardiogram, cinchonism, hypotension, high-degree atrioventricular block, and ventricular arrhythmias. (mhmedical.com)
Malaria9
- Quinidine is also sometimes used to treat malaria. (medlineplus.gov)
- Although intravenous quinidine is sometimes used to treat Plasmodium falciparum malaria, the future availability of this agent is uncertain. (wikipedia.org)
- Intravenous quinidine is indicated whenever oral therapy is not possible, in high-density infections (greater than 5% of red blood cells infected), and in the presence of complications such as cerebral malaria or acute renal failure. (cdc.gov)
- Quinine, a famous malaria treatment, and quinidine , an antiarrhythmic medication, are made from the bark of the cinchona tree. (wordnik.com)
- Diastereoisomers of quinidine and quinine are used to treat arrhythmia and malaria, respectively. (mdpi.com)
- Quinidine is used to treat abnormal heart rhythms and malaria. (rxwiki.com)
- Quinine and quinidine: a comparison of EKG effects during the treatment of malaria. (tropmedres.ac)
- We recorded electrocardiograms from 31 patients receiving quinine and 14 patients receiving quinidine for the treatment of Plasmodium falciparum malaria. (tropmedres.ac)
- Intravenous quinidine is also indicated for treatment of P. falciparum malaria. (chemeurope.com)
Concentrations17
- At micromolar concentrations, quinidine inhibits Na+/K+-ATPase by binding to the same receptor sites as the digitalis glycosides such as ouabain. (wikipedia.org)
- Concomitant administration of phenytoin increases hepatic metabolism, and therefore decreases half-life and serum quinidine concentrations. (labcorp.com)
- Through a MEDLINE search of all English medical literature (1966 to 1994) documenting possible interactions between quinidine and erythromycin, retrospective patient chart review, and analysis of the relationship between serum quinidine concentrations and significant clinical events, deduce the possibility of a quinidine and erythromycin pharmacokinetic and pharmacodynamic interaction in this particular patient case. (biomedsearch.com)
- RESULTS: This case demonstrated a probable erythromycin-quinidine pharmacokinetic interaction that led to a decrease in quinidine apparent clearance, an increase in quinidine serum concentrations, and a possible quinidine toxicity. (biomedsearch.com)
- CONCLUSION: Serum quinidine concentrations, electrocardiograms, and other factors that may predispose patients to torsades de pointes, such as hypokalemia and hypomagnesemia, should be monitored closely if quinidine is coadministered with erythromycin. (biomedsearch.com)
- The activity of this low affinity component was unaffected by quinidine in the concentrations studied. (nih.gov)
- May be increased to 600 mg PO every 6 hours if needed, based on serum quinidine concentrations. (pdr.net)
- Moreover, the formation of 3-hydroxyquinidine (detected only in perfusate as unconjugated 3-hydroxyquinidine) remained relatively linear while the formation of O-desmethylquinidine (present in bile and perfusate mostly as conjugates) apparently approached saturation kinetics within the quinidine concentrations used. (aspetjournals.org)
- The dose-dependent character of quinidine elimination cannot be attributed to changes in drug binding, as the blood/plasma ratio (4.07) and the degree of drug unbound in plasma (66.5%) remained unaltered for the quinidine concentrations used. (aspetjournals.org)
- Quinidine serum concentrations after an intravenous dose (circles with solid line) and three different oral tablets (doses normalized to provide 200 mg of quinidine base systemically). (mhmedical.com)
- After an intravenous dose, quinidine serum concentrations decline according to a two-compartment model, which demonstrates a distribution phase that lasts for 20-30 minutes postinjection. (mhmedical.com)
- Cinchonism is a collection of symptoms that includes tinnitus, blurred vision, lightheadedness, tremor, giddiness, and altered hearing which decreases in severity with lower quinidine concentrations. (mhmedical.com)
- The anticholinergic actions of quinidine predominate at lower plasma concentrations. (brainkart.com)
- Higher concentrations of quinidine have a direct effect of depressing the rate of spontaneous diastolic depolarization. (brainkart.com)
- Serum K + concentrations have a major influence on the activity of quinidine on cardiac tissue. (brainkart.com)
- Low extracel-lular K + concentrations antagonize the depressant ef-fects of quinidine on membrane responsiveness, whereas high extracellular K + concentrations increase quinidine's ability to depress membrane responsive-ness. (brainkart.com)
- At normal therapeutic plasma concentrations, quinidine prolongs the PR, the QRS, and the QT intervals. (brainkart.com)
Dosage3
- When oral quinidine is given as a rapidly absorbed dosage form such as quinidine sulfate tablets, a similar distribution phase is also observed with a duration of 20-30 minutes. (mhmedical.com)
- No data regarding the Paedriatic dosage details of Quinidine is available. (druginfosys.com)
- No data regarding the neonatal dosage details of Quinidine is available. (druginfosys.com)
Combination of dextromethorphan2
- The combination of dextromethorphan and quinidine comes as a capsule to take by mouth. (medlineplus.gov)
- Take the combination of dextromethorphan and quinidine exactly as directed. (medlineplus.gov)
Toxicity3
- Quinidine intoxication can lead to a collection of symptoms collectively known as cinchonism, with tinnitus (ringing in the ears) being among the most characteristic and common symptoms of this toxicity syndrome. (wikipedia.org)
- Cinchonism is usually a sign of chronic quinidine toxicity, but it may appear in sensitive patients after a single moderate dose of several hundred milligrams. (drugs.com)
- These reagents are used to measure quinidine levels in patients, e.g., to determine the adequacy of therapy, and in the diagnosis of a drug overdose or drug-related toxicity. (medicalproductguide.com)
Kwin1
- QUINIDINE (KWIN i deen) is an antiarrhythmic drug. (lifebridgehealth.org)
Inhibits5
- Quinidine also inhibits the transport protein P-glycoprotein and so can cause some peripherally acting drugs such as loperamide to have central nervous system side effects, such as respiratory depression, if the two drugs are coadministered. (wikipedia.org)
- quinidine is a drug that inhibits the metabolism of dextromethorphan which results in a sustained elevation of dextromethorphan in the brain. (mssociety.ca)
- Inhibits the metabolism of quinidine by inhibiting hepatic microsomal enzymes, thereby increasing its effect. (vetstream.com)
- Quinidine, a class Ia antiarrhythmic agent that inhibits outward transient K current (I to1 ), has been proposed as an adjuvant treatment in BrS patients (2-4) , but there are limited data about its long-term effectiveness. (onlinejacc.org)
- Quinidine inhibits transmembrane sodium influx into the conduction system of the heart, thereby decreasing conduction velocity. (mhmedical.com)
Dose of quinidine2
- The company reformulated the drug with a lower dose of quinidine and conducted new studies, she said. (thefreedictionary.com)
- Your doctor may adjust your dose of quinidine if you are a poor metabolizer. (rxwiki.com)
Davis's Drug Guide1
- dextromethorphan/quinidine is a topic covered in the Davis's Drug Guide . (unboundmedicine.com)
Effect of quinidine4
- The effect of quinidine on the ion channels is to prolong the cardiac action potential, thereby prolonging the QT interval on the surface ECG. (wikipedia.org)
- As measured by antiarrhythmic effects in animals, by QTc prolongation in human volunteers, or by various in vitro techniques, 3HQ has at least half the antiarrhythmic activity of the parent compound, so it may be responsible for a substantial fraction of the effect of quinidine sulfate in chronic use. (nih.gov)
- The indirect effect of quinidine on the sinoatrial node is a result of the drug's potential to exert an anti-cholinergic action resulting in a slight increase in heart rate. (brainkart.com)
- The effect of quinidine on digitoxin single-dose pharmacokinetics was evaluated in five healthy adults. (elsevier.com)
Quinine and quinidine1
- The present invention provides methods for purifying, identifying and using optically active isomers of quinine and quinidine as well as compositions comprising such optically active isomers. (freepatentsonline.com)
Dextromethorphan hydrobromide and quinidine sulfate1
- This medication contains a combination of two medications: dextromethorphan hydrobromide and quinidine sulfate. (rxwiki.com)
Tablets7
- Quinidine sulfate tablets are usually is taken every 6 hours. (medlineplus.gov)
- The absolute bioavailability of quinidine from quinidine sulfate tablets is about 70%, but this varies widely (45 to 100%) between patients. (nih.gov)
- Crush the tablets to a fine powder or use the quinidine sulfate powder. (uspharmacist.com)
- Do not crush or chew quinidine tablets. (rxwiki.com)
- Immediate-release quinidine tablets (diamonds with dashed line) are rapidly absorbed and also show a distinct distribution phase. (mhmedical.com)
- Quinidine Sulfate Controlled-Release Tablets is associated with an increased risk of death when used to treat non-life-threatening irregular heartbeat. (drugspedia.net)
- Ask your health care provider if Quinidine Sulfate Controlled-Release Tablets may interact with other medicines that you take. (drugspedia.net)
Alkaloid4
- Their great value depends upon the presence of certain alkaloid substances called quinine, cinchonine, and quinidine , which exist in the bark in combination with tannic and other acids. (wordnik.com)
- Quinidine is an alkaloid extracted from the bark of the Cinchona tree with class 1A antiarrhythmic and antimalarial effects. (fishersci.com)
- Quinidine is an alkaloid extracted from the bark of the genus Cinchona ledgeriana (Moens). (hardware-wholesale.com)
- Quinidine is an alkaloid obtained from various species of Cinchona or its hybrids, from Remijia pedunculata, or from quinine. (brainkart.com)
Oral quinidine2
- The elimination half-life of oral quinidine is 6 to 8 hours, and it is eliminated by the cytochrome P450 system in the liver. (wikipedia.org)
- the protocol was conducted once while each subject was taking oral quinidine, for 3 weeks, and then repeated 10 days after discontinuing quinidine treatment. (elsevier.com)
Therapeutic4
- If this regimen is well tolerated, if the serum quinidine level is still well within the laboratory's therapeutic range , and if this regimen has not resulted in conversion, then the dose may be cautiously raised. (rxlist.com)
- What we have done is recognized that you can inhibit ones ability to metabolize dextromethorphan by adding quinidine , which is a therapeutic. (wordnik.com)
- Quinidine has a narrow therapeutic index (serum concentration range: 2-6 mcg/ml). (pdr.net)
- The generally accepted therapeutic range for quinidine is 2-6 μg/mL. (mhmedical.com)
Doses3
- The most important of quinidine's metabolites is 3-hydroxyquinidine (3HQ), serum levels of which can exceed those of quinidine in patients receiving conventional doses of quinidine sulfate. (nih.gov)
- A genetically determined pharmacokinetic and pharmacodynamic interaction between quinidine and single doses of encainide in healthy volunteers has previously been described. (aspetjournals.org)
- However, quinidine may remain in the bodies of older adults longer than it does in younger adults, which may increase the risk of side effects and which may require lower doses. (allinahealth.org)
Side effects of dextromethorphan2
- Some side effects of dextromethorphan / quinidine may occur that usually do not need medical attention. (drugs.com)
- Common side effects of dextromethorphan/quinidine may include diarrhea and vomiting. (rxwiki.com)
Interact with dextromethorphan and quinidine3
- Many other medications may also interact with dextromethorphan and quinidine, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list. (medlineplus.gov)
- Some medicines can interact with dextromethorphan and quinidine and should not be used at the same time. (wellspan.org)
- These medicines may interact with dextromethorphan and quinidine and cause a serious condition called serotonin syndrome. (uncmedicalcenter.org)
Thrombocytopenia2
- Quinidine can cause thrombocytopenia, granulomatous hepatitis, myasthenia gravis, and torsades de pointes (dangerous heart rhythm), so is not used much today. (wikipedia.org)
- Quinidine-induced thrombocytopenia (low platelet count) is mediated by the immune system, and may lead to thrombocytic purpura. (wikipedia.org)
Pharmacokinetics1
- Inhibition of UGT2B7 by quinidine was also investigated further, because the effects of this compound on morphine pharmacokinetics (a known UGT2B7 substrate) have been ascribed to inhibition of P-glycoprotein. (aspetjournals.org)
Torsades de poin2
- Serious cardiovascular events, including QT prolongation, torsades de pointes, ventricular tachycardia, cardiac arrest, and/or sudden death have occurred in patients using cisapride, pimozide, levacetylmethadol (levomethadyl), methadone or quinidine concomitantly with itraconazole and/or other CYP3A4 inhibitors. (thefreedictionary.com)
- QT prolongation and development of torsades de pointes with the concomitant administration of oral erythromycin base and quinidine. (webmd.com)
Isomer of quinine3
- Quinidine is an isomer of quinine. (sigmaaldrich.com)
- Quinidine is the dextrorotatory isomer of quinine. (brainkart.com)
- Immunoassay reagents intended to perform quantitative analyses on a body fluid sample (e.g., serum, plasma) to measure the level of quinidine, an optical isomer of quinine, present in the sample. (medicalproductguide.com)
10mg1
- Dextromethorphan/quinidine (DM/Q) 20mg/10mg one capsule once daily for 1 week, followed by DM/Q 20mg /10 mg twice daily for subsequent 4 weeks, and finally DM/Q 20mg/10mg once daily for 7days. (clinicaltrials.gov)
Antiarrhythmic drugs3
- Taking antiarrhythmic drugs, including quinidine, may increase the risk of death. (medlineplus.gov)
- 47357] Guidelines recommend quinidine 324 to 648 mg PO every 8 hours as an option for the maintenance of sinus rhythm in patients with atrial fibrillation only when other antiarrhythmic drugs cannot be used. (pdr.net)
- A unifying molecular model for the interaction of antiarrhythmic drugs with cardiac sodium channels: application to quinidine and lidocaine. (semanticscholar.org)
Serum quinidine concentration2
- Adjust dosages to produce a serum quinidine concentration of 2 to 6 mcg/mL. (pdr.net)
- When given intravenously, the serum quinidine concentration-time curve follows a two-compartment model. (mhmedical.com)
Antibodies recognize quinidine1
- Specificity: These antibodies recognize quinidine. (qedbio.com)
Combined with dextromethorphan1
- When combined with dextromethorphan, quinidine works by increasing the amount of dextromethorphan in the body. (medlineplus.gov)
Concentration and quinidine1
- Experimental data is presented and discussed on the effects of temperature, K and Na concentration, and quinidine on transmembrane ion fluxes and the incidence of fibrillation in isolated rabbit atria. (ahajournals.org)
Drugs9
- tell your doctor and pharmacist if you are allergic to quinidine, quinine, or any other drugs. (medlineplus.gov)
- Caffeine interferes with drugs that regulate heart rhythm, such as quinidine and propranolol (Inderal). (yourdictionary.com)
- Results show that both drugs block the hERG channel, with quinine 14-fold less potent than quinidine. (mdpi.com)
- The mutation decreases affinity of the two drugs with hERG, and quinine was more potent than quinidine in F656C-hERG blockage. (mdpi.com)
- Quinidine belongs to a group of drugs called antiarrhythmics. (rxwiki.com)
- CYP2D6 is a protein in your body that is involved in the elimination of quinidine and other drugs from your body. (rxwiki.com)
- The half-life of quinidine may be reduced by as much as 50% as a consequence of hepatic enzyme induction by these drugs. (vetstream.com)
- If you are taking monoamine oxidase inhibitors (MAOIs), quinidine, or quinidine-related drugs. (nuedexta.com)
- If you have previously had an allergic reaction to dextromethorphan, quinidine or quinidine-like drugs. (nuedexta.com)
Atrial fibrillation2
- 1 After ventricular rate has been controlled, quinidine therapy can be used to chemically convert atrial fibrillation to normal sinus rhythm for a patient. (mhmedical.com)
- Quinidine maintains normal heart rhythm following cardioversion of atrial fibrillation or flutter. (medscape.com)
Automaticity3
- Because it slows conduction and prolongs the refractory period of the accessory pathway and suppresses automaticity of ectopic pacemakers, quinidine may prevent recurrences of paroxysmal supraventricular tachycardia caused by reentry over a concealed pathway or AV reciprocating tachycardia associated with the Wolff-Parkinson-White syndrome. (labcorp.com)
- Automaticity is decreased during quinidine therapy. (mhmedical.com)
- Quinidine can depress the automaticity of ventricu-lar pacemakers by depressing the slope of phase 4 de-polarization. (brainkart.com)
Antiarrhythmics2
- Quinidine is in a class of medications called antiarrhythmics. (medlineplus.gov)
- Quinidine is in a class of medications called antiarrhythmics (abnormal heart rhythm). (rxwiki.com)
Form of quinidine2
- The permanently charged quinidinium compound produced nearly identical effects as quinidine when present only on cytoplasmic side of the channel, suggesting the positive-charged form of quinidine is responsible for the effects on the channel. (aspetjournals.org)
- These data indicate that 1) the charged form of quinidine blocks the HK2 channel after it opens, 2) binding occurs within the transmembrane electrical field (probably in or near the ion permeation pathway), and 3) unbinding is required before the channel can close. (aspetjournals.org)
Increase in quinidine1
- The disposition of quinidine and the kinetics of metabolite formation were studied in the once-through perfused rat liver preparation by the stepwise increase in quinidine concentration. (aspetjournals.org)
Metabolism of quinidine1
- Possible inhibition of hepatic metabolism of quinidine by erythromycin. (webmd.com)
Interaction of quinidine2
- The interaction of quinidine and other local anesthetic/antiarrhythmic agents with voltage-gated ion channels has been proposed to be the result of binding of these compounds within the inner vestibule of the channel pore ( Hille, 1977 ). (aspetjournals.org)
- The interaction of quinidine with a cloned human cardiac potassium channel (HK2) expressed in a stable mouse L cell line was studied using the whole-cell tight-seal voltage-clamp technique. (aspetjournals.org)
Elimination of quinidine1
- Rapid elimination of quinidine in pediatric patients. (ucdenver.edu)
Pseudobulbar2
- Dextromethorphan/quinidine is a prescription medication approved for the treatment of pseudobulbar affect (PBA), a condition characterized by involuntary, sudden, uncontrolled episodes of laughing or crying, when there appears to be nothing to laugh or cry about. (rxwiki.com)
- Dextromethorphan/quinidine is a prescription medication is used to treat pseudobulbar affect (PBA) a condition of sudden, frequent outbursts of crying and laughing that can not be controlled. (rxwiki.com)
Antigen1
- Antigen: Quinidine conjugated to KLH. (qedbio.com)
Inhibition3
- It is concluded that the effect of this drug interaction in patients is determined by differential sensitivities to inhibition by quinidine of encainide O-demethylation and subsequent ODE 3-methoxylation. (aspetjournals.org)
- Mechanism of inhibition of mouse Slo3 (KCa 5.1) potassium channels by quinine, quinidine and barium. (guidetopharmacology.org)
- Quinidine can relax vascular smooth muscle directly as well as indirectly by inhibition of α 1 -adrenoceptors. (brainkart.com)
Sodium9
- Quinidine acts as a blocker of voltage-gated sodium channels. (wikipedia.org)
- Like all other class I antiarrhythmic agents, quinidine primarily works by blocking the fast inward sodium current (INa). (wikipedia.org)
- Quinidine stabilizes the neuronal membrane by binding to and inhibiting voltage-gated sodium channels, thereby inhibiting the sodium influx required for the initiation and conduction of impulses resulting in an increase of the threshold for excitation and decreased depolarization during phase 0 of the action potential. (fishersci.com)
- In subjects with the extensive metabolizer phenotype, quinidine blunted encainide-induced QRS prolongation (a marker of sodium channel block) because it impaired encainide biotransformation to the potent active metabolites O-desmethyl encainide (ODE) and 3-methoxy-O-desmethyl encainide. (aspetjournals.org)
- Therefore, the purpose of this study was to test the hypothesis that quinidine would inhibit sodium channel block (and by inference arrhythmia suppression) during encainide therapy in patients with the extensive metabolizer phenotype. (aspetjournals.org)
- Like all other class I antiarrhythmic agents, quinidine primarily works by blocking the fast inward sodium current (INa) which causes the phase 0 depolarization of the cardiac action potential to decrease (decreased Vmax). (qedbio.com)
- Quinidine is the right-handed body of quinine, which has similar pharmacological properties, but quinidine is 5 to 10 times stronger than quinine in the heart, and it binds to the lipoprotein of the sodium channel on the myocardial cell membrane, making the channel The gate narrows to prevent Na+ inflow, resulting in a decrease in the depolarization speed of the 0 phase and a slower conduction. (hardware-wholesale.com)
- Several recent studies have reported potassium sodium-activated channel subfamily T member 1 ( KCNT1 ) mutations in epilepsy patients on quinidine therapy. (jle.com)
- Quinidine dampens the excitability of cardiac and skeletal muscles by blocking sodium and potassium currents across cellular membranes. (medicalproductguide.com)
Grapefruit juice1
- Avoid drinking grapefruit juice while taking quinidine. (empowher.com)
Conduction3
- These findings suggest that the quinidine-induced subconductance activity may be the result of a partial occlusion of the channel pore interfering with ion conduction. (aspetjournals.org)
- The net effect of these cellular changes is that quinidine causes increased refractoriness and decreased conduction in heart conduction tissue which establishes a bidirectional block in reentrant pathways. (mhmedical.com)
- Both the direct and indirect actions of quinidine are important in determining its ultimate effect on A-V conduction. (brainkart.com)
CYP2D61
- Goldstein and his colleagues tested the supplement against quinidine , a known CYP2D6 inhibitor. (thefreedictionary.com)
Antimalarial1
- Quinidine exerts its antimalarial activity by acting primarily as an intra-erythrocytic schizonticide through association with the heme polymer (hemazoin) in the acidic food vacuole of the parasite thereby preventing further polymerization by heme polymerase enzyme. (fishersci.com)
Take quinidine6
- Take quinidine at around the same times every day. (medlineplus.gov)
- Take quinidine exactly as directed. (medlineplus.gov)
- Continue to take quinidine even if you feel well. (medlineplus.gov)
- Your doctor may tell you not to take quinidine. (medlineplus.gov)
- Take quinidine at the same time each day in regularly spaced intervals. (empowher.com)
- Is it safe to take quinidine during pregnancy? (sharecare.com)