AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesAnthropology, Education, Sociology and Social PhenomenaTechnology, Industry, AgricultureInformation ScienceHealth Care
QuinidineQuinineProcainamideAnti-Arrhythmia AgentsCytochrome P-450 CYP2D6DisopyramideFlecainideCinchona AlkaloidsDextromethorphanOxidoreductases, O-DemethylatingPropafenoneSparteineDebrisoquinLidocainePseudobulbar PalsyEncyclopedias as TopicCinchonaDictionaries, MedicalDictionaries as TopicDictionaries, ChemicalArrhythmias, CardiacMalariaTabletsBiological AvailabilityHalf-LifeAdministration, OralOrosomucoidInjections, IntravenousDrug LabelingDrug RepositioningProduct LabelingUnited States Food and Drug AdministrationPrescription DrugsSearch EngineTachycardia, SupraventricularWolff-Parkinson-White SyndromeTachycardia, ParoxysmalTachycardia, Atrioventricular Nodal ReentryAtrial FlutterCatheter AblationFormularies as TopicEconomics, PharmaceuticalDrug IndustryAcademies and InstitutesSecurity MeasuresLegislation, FoodLibrary ServicesLibraries, MedicalInjectionsHeart DiseasesAlkaloidsMalaria, FalciparumHeart
Quinidine
An optical isomer of quinine, extracted from the bark of the CHINCHONA tree and similar plant species. This alkaloid dampens the excitability of cardiac and skeletal muscles by blocking sodium and potassium currents across cellular membranes. It prolongs cellular ACTION POTENTIALS, and decreases automaticity. Quinidine also blocks muscarinic and alpha-adrenergic neurotransmission.
Quinine
An alkaloid derived from the bark of the cinchona tree. It is used as an antimalarial drug, and is the active ingredient in extracts of the cinchona that have been used for that purpose since before 1633. Quinine is also a mild antipyretic and analgesic and has been used in common cold preparations for that purpose. It was used commonly and as a bitter and flavoring agent, and is still useful for the treatment of babesiosis. Quinine is also useful in some muscular disorders, especially nocturnal leg cramps and myotonia congenita, because of its direct effects on muscle membrane and sodium channels. The mechanisms of its antimalarial effects are not well understood.
Procainamide
A class Ia antiarrhythmic drug that is structurally-related to PROCAINE.
Anti-Arrhythmia Agents
Agents used for the treatment or prevention of cardiac arrhythmias. They may affect the polarization-repolarization phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibers. Anti-arrhythmia agents are often classed into four main groups according to their mechanism of action: sodium channel blockade, beta-adrenergic blockade, repolarization prolongation, or calcium channel blockade.
Cytochrome P-450 CYP2D6
A cytochrome P450 enzyme that catalyzes the hydroxylation of many drugs and environmental chemicals, such as DEBRISOQUINE; ADRENERGIC RECEPTOR ANTAGONISTS; and TRICYCLIC ANTIDEPRESSANTS. This enzyme is deficient in up to 10 percent of the Caucasian population.
Disopyramide
A class I anti-arrhythmic agent (one that interferes directly with the depolarization of the cardiac membrane and thus serves as a membrane-stabilizing agent) with a depressant action on the heart similar to that of guanidine. It also possesses some anticholinergic and local anesthetic properties.
Flecainide
A potent anti-arrhythmia agent, effective in a wide range of ventricular and atrial ARRHYTHMIAS and TACHYCARDIAS.
Cinchona Alkaloids
Alkaloids extracted from various species of Cinchona.
Dextromethorphan
Methyl analog of DEXTRORPHAN that shows high affinity binding to several regions of the brain, including the medullary cough center. This compound is an NMDA receptor antagonist (RECEPTORS, N-METHYL-D-ASPARTATE) and acts as a non-competitive channel blocker. It is one of the widely used ANTITUSSIVES, and is also used to study the involvement of glutamate receptors in neurotoxicity.
Oxidoreductases, O-Demethylating
Drug metabolizing enzymes which oxidize methyl ethers. Usually found in liver microsomes.
Propafenone
An antiarrhythmia agent that is particularly effective in ventricular arrhythmias. It also has weak beta-blocking activity.
Sparteine
A quinolizidine alkaloid isolated from several FABACEAE including LUPINUS; SPARTIUM; and CYTISUS. It has been used as an oxytocic and an anti-arrhythmia agent. It has also been of interest as an indicator of CYP2D6 genotype.
Debrisoquin
An adrenergic neuron-blocking drug similar in effects to GUANETHIDINE. It is also noteworthy in being a substrate for a polymorphic cytochrome P-450 enzyme. Persons with certain isoforms of this enzyme are unable to properly metabolize this and many other clinically important drugs. They are commonly referred to as having a debrisoquin 4-hydroxylase polymorphism.
Lidocaine
A local anesthetic and cardiac depressant used as an antiarrhythmia agent. Its actions are more intense and its effects more prolonged than those of PROCAINE but its duration of action is shorter than that of BUPIVACAINE or PRILOCAINE.
Pseudobulbar Palsy
A syndrome characterized by DYSARTHRIA, dysphagia, dysphonia, impairment of voluntary movements of tongue and facial muscles, and emotional lability. This condition is caused by diseases that affect the motor fibers that travel from the cerebral cortex to the lower BRAIN STEM (i.e., corticobulbar tracts); including MULTIPLE SCLEROSIS; MOTOR NEURON DISEASE; and CEREBROVASCULAR DISORDERS. (From Adams et al., Principles of Neurology, 6th ed, p489)
Encyclopedias as Topic
Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)
Cinchona
A genus of rubiaceous South American trees that yields the toxic CINCHONA ALKALOIDS from their bark; QUININE; QUINIDINE; chinconine, cinchonidine and others are used to treat MALARIA and CARDIAC ARRHYTHMIAS.
Dictionaries, Medical
Dictionaries as Topic
Lists of words, usually in alphabetical order, giving information about form, pronunciation, etymology, grammar, and meaning.
Dictionaries, Chemical
Arrhythmias, Cardiac
Any disturbances of the normal rhythmic beating of the heart or MYOCARDIAL CONTRACTION. Cardiac arrhythmias can be classified by the abnormalities in HEART RATE, disorders of electrical impulse generation, or impulse conduction.
Malaria
A protozoan disease caused in humans by four species of the PLASMODIUM genus: PLASMODIUM FALCIPARUM; PLASMODIUM VIVAX; PLASMODIUM OVALE; and PLASMODIUM MALARIAE; and transmitted by the bite of an infected female mosquito of the genus ANOPHELES. Malaria is endemic in parts of Asia, Africa, Central and South America, Oceania, and certain Caribbean islands. It is characterized by extreme exhaustion associated with paroxysms of high FEVER; SWEATING; shaking CHILLS; and ANEMIA. Malaria in ANIMALS is caused by other species of plasmodia.
Tablets
Solid dosage forms, of varying weight, size, and shape, which may be molded or compressed, and which contain a medicinal substance in pure or diluted form. (Dorland, 28th ed)
Biological Availability
The extent to which the active ingredient of a drug dosage form becomes available at the site of drug action or in a biological medium believed to reflect accessibility to a site of action.
Half-Life
The time it takes for a substance (drug, radioactive nuclide, or other) to lose half of its pharmacologic, physiologic, or radiologic activity.
Administration, Oral
The giving of drugs, chemicals, or other substances by mouth.
Orosomucoid
Injections, Intravenous
Injections made into a vein for therapeutic or experimental purposes.
Drug Labeling
Use of written, printed, or graphic materials upon or accompanying a drug container or wrapper. It includes contents, indications, effects, dosages, routes, methods, frequency and duration of administration, warnings, hazards, contraindications, side effects, precautions, and other relevant information.
Drug Repositioning
The deliberate and methodical practice of finding new applications for existing drugs.
Product Labeling
Use of written, printed, or graphic materials upon or accompanying a product or its container or wrapper. It includes purpose, effect, description, directions, hazards, warnings, and other relevant information.
United States Food and Drug Administration
An agency of the PUBLIC HEALTH SERVICE concerned with the overall planning, promoting, and administering of programs pertaining to maintaining standards of quality of foods, drugs, therapeutic devices, etc.
Prescription Drugs
Drugs that cannot be sold legally without a prescription.
Search Engine
Software used to locate data or information stored in machine-readable form locally or at a distance such as an INTERNET site.
Tachycardia, Supraventricular
A generic expression for any tachycardia that originates above the BUNDLE OF HIS.
Wolff-Parkinson-White Syndrome
A form of ventricular pre-excitation characterized by a short PR interval and a long QRS interval with a delta wave. In this syndrome, atrial impulses are abnormally conducted to the HEART VENTRICLES via an ACCESSORY CONDUCTING PATHWAY that is located between the wall of the right or left atria and the ventricles, also known as a BUNDLE OF KENT. The inherited form can be caused by mutation of PRKAG2 gene encoding a gamma-2 regulatory subunit of AMP-activated protein kinase.
Tachycardia, Paroxysmal
Abnormally rapid heartbeats with sudden onset and cessation.
Tachycardia, Atrioventricular Nodal Reentry
Abnormally rapid heartbeats caused by reentry of atrial impulse into the dual (fast and slow) pathways of ATRIOVENTRICULAR NODE. The common type involves a blocked atrial impulse in the slow pathway which reenters the fast pathway in a retrograde direction and simultaneously conducts to the atria and the ventricles leading to rapid HEART RATE of 150-250 beats per minute.
Atrial Flutter
Rapid, irregular atrial contractions caused by a block of electrical impulse conduction in the right atrium and a reentrant wave front traveling up the inter-atrial septum and down the right atrial free wall or vice versa. Unlike ATRIAL FIBRILLATION which is caused by abnormal impulse generation, typical atrial flutter is caused by abnormal impulse conduction. As in atrial fibrillation, patients with atrial flutter cannot effectively pump blood into the lower chambers of the heart (HEART VENTRICLES).
Catheter Ablation
Removal of tissue with electrical current delivered via electrodes positioned at the distal end of a catheter. Energy sources are commonly direct current (DC-shock) or alternating current at radiofrequencies (usually 750 kHz). The technique is used most often to ablate the AV junction and/or accessory pathways in order to interrupt AV conduction and produce AV block in the treatment of various tachyarrhythmias.
Formularies as Topic
Works about lists of drugs or collections of recipes, formulas, and prescriptions for the compounding of medicinal preparations. Formularies differ from PHARMACOPOEIAS in that they are less complete, lacking full descriptions of the drugs, their formulations, analytic composition, chemical properties, etc. In hospitals, formularies list all drugs commonly stocked in the hospital pharmacy.
Economics, Pharmaceutical
Economic aspects of the fields of pharmacy and pharmacology as they apply to the development and study of medical economics in rational drug therapy and the impact of pharmaceuticals on the cost of medical care. Pharmaceutical economics also includes the economic considerations of the pharmaceutical care delivery system and in drug prescribing, particularly of cost-benefit values. (From J Res Pharm Econ 1989;1(1); PharmacoEcon 1992;1(1))
Drug Industry
That segment of commercial enterprise devoted to the design, development, and manufacture of chemical products for use in the diagnosis and treatment of disease, disability, or other dysfunction, or to improve function.
Academies and Institutes
Organizations representing specialized fields which are accepted as authoritative; may be non-governmental, university or an independent research organization, e.g., National Academy of Sciences, Brookings Institution, etc.
Security Measures
Regulations to assure protection of property and equipment.
Legislation, Food
Laws and regulations concerned with industrial processing and marketing of foods.
Library Services
Services offered to the library user. They include reference and circulation.
Libraries, Medical
Injections
Introduction of substances into the body using a needle and syringe.
Heart Diseases
Pathological conditions involving the HEART including its structural and functional abnormalities.
Alkaloids
Organic nitrogenous bases. Many alkaloids of medical importance occur in the animal and vegetable kingdoms, and some have been synthesized. (Grant & Hackh's Chemical Dictionary, 5th ed)
Malaria, Falciparum
Malaria caused by PLASMODIUM FALCIPARUM. This is the severest form of malaria and is associated with the highest levels of parasites in the blood. This disease is characterized by irregularly recurring febrile paroxysms that in extreme cases occur with acute cerebral, renal, or gastrointestinal manifestations.
Heart
The hollow, muscular organ that maintains the circulation of the blood.

Transport of fluid by lens epithelium. (1/618)

We report for the first time that cultured lens epithelial cell layers and rabbit lenses in vitro transport fluid. Layers of the alphaTN4 mouse cell line and bovine cell cultures were grown to confluence on permeable membrane inserts. Fluid movement across cultured layers and excised rabbit lenses was determined by volume clamp (37 degrees C). Cultured layers transported fluid from their basal to their apical sides against a pressure head of 3 cmH2O. Rates were (in microliter. h-1. cm-2) 3.3 +/- 0.3 for alphaTN4 cells (n = 27) and 4.7 +/- 1.0 for bovine layers (n = 6). Quinidine, a blocker of K+ channels, and p-chloromercuribenzenesulfonate and HgCl2, inhibitors of aquaporins, inhibited fluid transport. Rabbit lenses transported fluid from their anterior to their posterior sides against a 2.5-cmH2O pressure head at 10.3 +/- 0.62 microliter. h-1. lens-1 (n = 5) and along the same pressure head at 12.5 +/- 1.1 microliter. h-1. lens-1 (n = 6). We calculate that this flow could wash the lens extracellular space by convection about once every 2 h and therefore might contribute to lens homeostasis and transparency.  (+info)

Effects of dauricine, quinidine, and sotalol on action potential duration of papillary muscles in vitro. (2/618)

AIM: To compare the characteristics of dauricine, sotalol, and quinidine on action potential duration (APD). METHODS: Using intracellular microelectrode method to record APD in guinea pig papillary muscles. RESULTS: Dauricine 20 mumol.L-1 prolonged action potential at 90% repolarization, the percent of APD prolongation were 22 +/- 8, 11 +/- 6, 9 +/- 5, 7 +/- 5, 6 +/- 3, 4.3 +/- 2.8, 4.5 +/- 2.8 at the cycle lengths of 200-2000 ms, dauricine became more effective in lengthening APD at short cycle lengths. The effect of dauricine on prolonging APD exhibited normal use-dependence, whereas quinidine 1 mumol.L-1 and sotalol 10 mumol.L-1 were less effective in lengthening APD at short cycle lengths. The effect of quinidine and sotalol on APD exhibited reverse use-dependence. CONCLUSSION: The effect of dauricine on APD depends on activation frequency.  (+info)

In vitro metabolism of quinidine: the (3S)-3-hydroxylation of quinidine is a specific marker reaction for cytochrome P-4503A4 activity in human liver microsomes. (3/618)

The aim of this study was to evaluate the (3S)-3-hydroxylation and the N-oxidation of quinidine as biomarkers for cytochrome P-450 (CYP)3A4 activity in human liver microsome preparations. An HPLC method was developed to assay the metabolites (3S)-3-hydroxyquinidine (3-OH-Q) and quinidine N-oxide (Q-N-OX) formed during incubation with microsomes from human liver and from Saccharomyces cerevisiae strains expressing 10 human CYPs. 3-OH-Q formation complied with Michaelis-Menten kinetics (mean values of Vmax and Km: 74.4 nmol/mg/h and 74.2 microM, respectively). Q-N-OX formation followed two-site kinetics with mean values of Vmax, Km and Vmax/Km for the low affinity isozyme of 15.9 nmol/mg/h, 76.1 microM and 0.03 ml/mg/h, respectively. 3-OH-Q and Q-N-OX formations were potently inhibited by ketoconazole, itraconazole, and triacetyloleandomycin. Isozyme specific inhibitors of CYP1A2, -2C9, -2C19, -2D6, and -2E1 did not inhibit 3-OH-Q or Q-N-OX formation, with Ki values comparable with previously reported values. Statistically significant correlations were observed between CYP3A4 content and formations of 3-OH-Q and Q-N-OX in 12 human liver microsome preparations. Studies with yeast-expressed isozymes revealed that only CYP3A4 actively catalyzed the (3S)-3-hydroxylation. CYP3A4 was the most active enzyme in Q-N-OX formation, but CYP2C9 and 2E1 also catalyzed minor proportions of the N-oxidation. In conclusion, our studies demonstrate that only CYP3A4 is actively involved in the formation of 3-OH-Q. Hence, the (3S)-3-hydroxylation of quinidine is a specific probe for CYP3A4 activity in human liver microsome preparations, whereas the N-oxidation of quinidine is a somewhat less specific marker reaction for CYP3A4 activity, because the presence of a low affinity enzyme is demonstrated by different approaches.  (+info)

Pseudo second degree atrioventricular block with bradycardia. Successful treatment with quinidine. (4/618)

Pseudo second degree atrioventricular block resulting from blocked His premature beats was successfully treated with quinidine. The diagnosis was proved by His bundle electrogam which showed both blocked and conducted His premature beats. The blocked His prematures produced second degree atrioventricular block by making the atrioventricular junction refractory. Quinidine abolished both conducted and blocked His extrasystoles. There has been no recurrence of arrhythmia during a one-year follow-up.  (+info)

Novel membrane transporter OCTN1 mediates multispecific, bidirectional, and pH-dependent transport of organic cations. (5/618)

In the present study, functional characteristics of organic cation transporter (OCTN)1, which was cloned as the pH-dependent tetraethylammonium (TEA) transporter when expressed in mammalian human embryonic kidney (HEK)293 cells, were further investigated using Xenopus oocytes as well as HEK293 cells as gene expression systems. When OCTN1-derived complementary RNA was injected into Xenopus oocytes, pH-dependent transport of [14C]TEA was observed as the same in HEK293 cells. In contrast, a replacement of sodium ions with potassium ions in the surrounding medium did not cause any change in [14C]TEA uptake in Xenopus oocytes expressed with OCTN1. In addition, when OCTN1 was expressed in HEK293 cells, efflux of TEA from the cells was pH dependent, with an accelerated rate at acidic external medium pH. Accordingly, membrane potential or sodium ions are suggested to have no influence on [14C]TEA transport and the transport activity of OCTN1 is directly affected by pH itself. Furthermore, addition of the unlabeled TEA in external medium enhanced the efflux of preloaded [14C]TEA. These observations suggest that OCTN1 is a pH-dependent and bidirectional TEA transporter. OCTN1-mediated [14C]TEA uptake was inhibited by various organic cations such as cimetidine, procainamide, pyrilamine, quinidine, quinine, and verapamil. In addition, uptakes of cationic compounds such as [3H]pyrilamine, [3H]quinidine, and [3H]verapamil and zwitterionic L-[3H]carnitine were increased by expression of OCTN1 in Xenopus oocytes. Accordingly, OCTN1 was functionally demonstrated to be a multispecific and pH-dependent organic cation transporter, which presumably functions as a proton/organic cation antiporter at the renal apical membrane and other tissues.  (+info)

Effects of a novel cardioprotective drug, JTV-519, on membrane currents of guinea pig ventricular myocytes. (6/618)

We investigated effects of a novel cardioprotective drug, JTV-519 (4-[3-(4-benzylpiperidin-1-yl)propionyl]-7-methoxy-2,3,4,5-tetrahy dro-1,4-benzothiazepine monohydrochloride) on membrane currents of guinea pig ventricular myocytes by whole-cell voltage and current clamp methods. The fast Na+ current (iNa) was activated by ramp pulses from various holding potentials of -90, -80 or -60 mV to 10 mV with various intervals. At 0.2 Hz, JTV-519 inhibited iNa in a concentration-dependent manner with an IC50 of approximately 1.2 and 2 microM at the holding potential of -60 and -90 mM, respectively, implicating a voltage-dependent block. Increasing the pulse frequency from 1 to 2 or 3.3 Hz in the presence of 1 microM JTV-519 shortened the time-course and increased the level of iNa block, indicating a frequency-dependent block. The time-course of iNa blocking by JTV-519 was slower than that of lidocaine and similar to that of quinidine. Ca2+ current (iCa) and the inwardly rectifying K+ current (iK1) were also inhibited by JTV-519. JTV-519 decreased the duration and the height of the plateau of the action potential. We conclude that JTV-519 has frequency- and voltage-dependent blocking effects on iNa as well as inhibition of iCa and iK1.  (+info)

Alkalinization-induced K+ current of the mouse megakaryocyte. (7/618)

We have recently found that mouse megakaryocytes responded to extracellular alkalinization to pH > 8.0, generating a K+ current under voltage-clamped conditions with the whole cell recording mode of the patch-clamp technique. The purpose of this study was to physiologically and pharmacologically characterize the alkaline-dependent K+ conductance of the megakaryocyte membrane. The alkalinization-induced K+ current (I(ALK)) did not seem to be Ca2+-dependent since I(ALK) was allowed to be generated under intracellularly Ca2+-buffered conditions with 10 mM EGTA, which completely prevented the generation of caffeine-induced Ca2+-activated currents of mouse megakaryocytes; and no [Ca2+]i elevation was evoked by the alkalinization protocol in contrast to a significant increase in [Ca2+]i in response to caffeine when [Ca2+]i was measured with a fura 2 ratiometry. I(ALK) was strongly suppressed with tetraethylammonium (TEA), 4-aminopyridine (4-AP) and streptomycin (SM), but was completely resistant to quinidine (QND). The values of IC50 for the suppression of I(ALK) with TEA, 4-AP and SM were 5.6, 0.47 and 1.5 mM, respectively. Voltage-gated K+ currents (I(K)) of the same megakaryocyte preparation were weakly suppressed with TEA and 4-AP, while they were significantly suppressed with either SM or QND. These results suggest that mouse megakaryocytes possess K+ conductance that was activated by extracellular alkalinization and that probably differs from conventional K+ conductance in its pharmacological properties.  (+info)

Enhancing effects of salicylate on tonic and phasic block of Na+ channels by class 1 antiarrhythmic agents in the ventricular myocytes and the guinea pig papillary muscle. (8/618)

OBJECTIVE: To study the interaction between salicylate and class 1 antiarrhythmic agents. METHODS: The effects of salicylate on class 1 antiarrhythmic agent-induced tonic and phasic block of the Na+ current (INa) of ventricular myocytes and the upstroke velocity of the action potential (Vmax) of papillary muscles were examined by both the patch clamp technique and conventional microelectrode techniques. RESULTS: Salicylate enhanced quinidine-induced tonic and phasic block of INa at a holding potential of -100 mV but not at a holding potential of -140 mV; this enhancement was accompanied by a shift of the hinfinity curve in the presence of quinidine in a further hyperpolarized direction, although salicylate alone did not affect INa. Salicylate enhanced the tonic and phasic block of Vmax induced by quinidine, aprindine and disopyramide but had little effect on that induced by procainamide or mexiletine; the enhancing effects were related to the liposolubility of the drugs. CONCLUSIONS: Salicylate enhanced tonic and phasic block of Na+ channels induced by class 1 highly liposoluble antiarrhythmic agents. Based on the modulated receptor hypothesis, it is probable that this enhancement was mediated by an increase in the affinity of Na+ channel blockers with high lipid solubility to the inactivated state channels.  (+info)

DailyMed - QUINIDINE SULFATE tabletDailyMed - QUINIDINE SULFATE tablet
Pharmacokinetics and Metabolism The absolute bioavailability of quinidine from quinidine sulfate tablets is about 70%, but this varies widely (45 to 100%) between patients. The less-than-complete bioavailability is the result of first-pass metabolism in the liver. Peak serum levels generally appear about 2 hours after dosing; the rate of absorption is somewhat slowed when the drug is taken with food, but the extent of absorption is not changed.. The volume of distribution of quinidine is 2 to 3 L/kg in healthy young adults, but this may be reduced to as little as 0.5 L/kg in patients with congestive heart failure, or increased to 3 to 5 L/kg in patients with cirrhosis of the liver. At concentrations of 2 to 5 mg/L (6.5 to 16.2 μmol/L), the fraction of quinidine bound to plasma proteins (mainly to α1-acid glycoprotein and to albumin) is 80 to 88% in adults and older children, but it is lower in pregnant women, and in infants and neonates it may be as low as 50 to 70%. Because α1-acid ...
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=a10b6ded-4fe0-4059-bd77-c45acc3c876d
Quinidine sulfate United States Pharmacopeia (USP) Reference Standard | 6591-63-5 | Sigma-AldrichQuinidine sulfate United States Pharmacopeia (USP) Reference Standard | 6591-63-5 | Sigma-Aldrich
Quinidine sulfate United States Pharmacopeia (USP) Reference Standard; CAS Number: 6591-63-5; Synonym: Quinidine sulfate salt dihydrate; Linear Formula: C40H48N4O4 · H2O4S · 2H2O; find USP-1595509 MSDS, related peer-reviewed papers, technical documents, similar products & more at Sigma-Aldrich.
https://www.sigmaaldrich.com/catalog/product/usp/1595509?lang=en®ion=US
Quinidine - definition of quinidine by The Free DictionaryQuinidine - definition of quinidine by The Free Dictionary
Define quinidine. quinidine synonyms, quinidine pronunciation, quinidine translation, English dictionary definition of quinidine. n. A bitter alkaloid, C20H24N2O2, that is a stereoisomer of quinine, used in the form of its salts to treat malaria and certain cardiac arrhythmias.
http://www.thefreedictionary.com/quinidines
Quinidine Lactate and Gluconate in the Suppression of Ectopic Ventricular Tachycardias Associated with Myocardial Infarction |...Quinidine Lactate and Gluconate in the Suppression of Ectopic Ventricular Tachycardias Associated with Myocardial Infarction |...
In dogs with myocardial infarction, produced by a standard technic, rapid persistent ectopic ventricular tachycardia develops. Intravenous quinidine lactate and quinidine gluconate effectively control the arrhythmia in 56 to 60 per cent of the animals, but produce toxic reactions in many of them. Morphine sulfate prevents vomiting and diarrhea from quinidine, but does not prevent convulsive movements. The most effective treatment of the arrhythmia was by use of morphine followed by quinidine gluconate. This combination was successful in 89 to 100 per cent of the cases. Principles for guidance in the treatment of severe ventricular arrhythmias have been drawn from these studies.. ...
http://circ.ahajournals.org/content/4/4/522
Molecular analysis of a binding site for quinidine in a human cardiac delayed rectifier K+ channel. Role of S6 in...Molecular analysis of a binding site for quinidine in a human cardiac delayed rectifier K+ channel. Role of S6 in...
The antiarrhythmic agent quinidine blocks the human cardiac hKv1.5 channel expressed in mammalian cells at therapeutically relevant concentrations (EC50, 6.2 mumol/L). Mechanistic analysis has suggested that quinidine acts as a cationic open-channel blocker at a site in the internal mouth of the ionic pore and that binding is stabilized by hydrophobic interactions. We tested these hypotheses using site-directed mutagenesis of residues proposed to line the internal mouth of the channel or of nearby residues. Amino acid substitutions in the midsection of S6 (T505I, T505V, T505S, and V512A) reduced the dissociation rate for quinidine, increased the affinity (0.7, 1.5, 3.4, and 1.4 mumol/L, respectively), and preserved both the voltage-dependent open channel-block mechanism and the electrical binding distance (0.19 to 0.22). In contrast, smaller or nonsignificant effects were observed for: deletion of the intracellular C-terminal domain, charge neutralizations in the region immediately C-terminal to S6,
https://www.semanticscholar.org/paper/Molecular-analysis-of-a-binding-site-for-quinidine-Yeola-Rich/1a0ef0036e404762f708202e658978fd9d4b495a
NUEDEXTA (Quinidine sulfate,Dextromethorphan) dosage, indication, interactions, side effects | EMPRNUEDEXTA (Quinidine sulfate,Dextromethorphan) dosage, indication, interactions, side effects | EMPR
NUEDEXTA (Quinidine sulfate,Dextromethorphan) drug information & product resources from MPR including dosage information, educational materials, & patient assistance.
http://www.endocrinologyadvisor.com/nuedexta/drug/3809/
NUEDEXTA (Quinidine sulfate,Dextromethorphan) dosage, indication, interactions, side effects | EMPR - ONANUEDEXTA (Quinidine sulfate,Dextromethorphan) dosage, indication, interactions, side effects | EMPR - ONA
NUEDEXTA (Quinidine sulfate,Dextromethorphan) drug information & product resources from MPR including dosage information, educational materials, & patient assistance.
https://www.oncologynurseadvisor.com/nuedexta/drug/3809/
Quinidine Sulfate 10 mg/mL Oral SuspensionQuinidine Sulfate 10 mg/mL Oral Suspension
Method of Preparation: Calculate the quantity of each ingredient for the amount to be prepared. Accurately weigh or measure each ingredient. Crush the tablets to a fine powder or use the quinidine sulfate powder. Add about 25 mL of Ora-Plus, and mix to form a smooth paste. Add the remaining Ora-Plus and mix well. In portions, add the Ora-Sweet or the Ora-Sweet SF, with thorough mixing between each addition, until the final volume is obtained. (Alternatively, Ora-Blend or Ora-Blend-SF could be used instead for this formulation.) Package and label.. Use: This preparation has been used as an antiarrhythmic agent for patients who cannot swallow solid dosage forms.. Packaging: Package in tight, light-resistant containers.. Labeling: Keep out of reach of children. Discard after ____ [time period]. Shake well before taking.. Stability: A beyond-use date of up to 60 days when stored at room temperature or in a refrigerator may be used for this preparation.1,2. Quality Control: Quality-control assessment ...
https://www.uspharmacist.com/article/quinidine-sulfate-10-mg-ml-oral-suspension
Quinidine sulfate / quinidine sulfate NDA 087909 international drug patent coverage, generic alternatives and suppliersQuinidine sulfate / quinidine sulfate NDA 087909 international drug patent coverage, generic alternatives and suppliers
Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice. ...
https://www.drugpatentwatch.com/p/NDA/087909
Assessment of the Efficacy Safety and Tolerability of AVP-786 (Deudextromethorphan Hydrobromide [d6-DM]/Quinidine Sulfate [Q]...Assessment of the Efficacy Safety and Tolerability of AVP-786 (Deudextromethorphan Hydrobromide [d6-DM]/Quinidine Sulfate [Q]...
Clinical trial for Agitation in Patients With Dementia of the Alzheimers Type , Assessment of the Efficacy Safety and Tolerability of AVP-786 (Deudextromethorphan Hydrobromide [d6-DM]/Quinidine Sulfate [Q]) for the Treatment of Agitation in Patients With Dementia of the Alzheimers Type
https://www.centerwatch.com/clinical-trials/listings/157886/agitation-in-patients-with-dementia-of-the-alzheimers-type-assessment-efficacy-safety/?section=elg&geo_lat=41.3661865&geo_lng=2.1164942&radius=10
Quinidine Gluconate Injection (quinidine gluconate) dose, indications, adverse effects, interactions... from PDR.netQuinidine Gluconate Injection (quinidine gluconate) dose, indications, adverse effects, interactions... from PDR.net
PDR Drug Summaries are concise point-of-care prescribing, dosing and administering information to help phsyicans more efficiently and accurately prescribe in their practice PDRs drug summaries are available free of charge and serve as a great resource for US based MDs, DOs, NPs and PAs in patient practice
http://www.pdr.net/drug-summary/Quinidine-Gluconate-Injection-quinidine-gluconate-981
VENTRICULAR TACHYCARDIA-A REPORT OF TEN CASES, EIGHT OF WHICH WERE TREATED WITH QUINIDINE WITH RECOVERY IN SEVEN* | Annals of...VENTRICULAR TACHYCARDIA-A REPORT OF TEN CASES, EIGHT OF WHICH WERE TREATED WITH QUINIDINE WITH RECOVERY IN SEVEN* | Annals of...
Review of the recent literature reveals little dealing with the effects of large doses of quinidine on ventricular tachycardia. No series comparable in size to this one has been noted within the past 15 years. McMillan1 recently reported two cases following coronary thrombosis treated successfully with quinidine. Reich2 reported a cure with a total of 185 grains given in a period of two and a half days, a dosage believed by him and also by Levine3 and Gold4 to be the largest dose given in a period of 60 hours. Some of the cases in this series had quinidine in ...
http://annals.org/aim/article-abstract/673248/ventricular-tachycardia-report-ten-cases-eight-which-were-treated-quinidine
Quinidine (Oral route, injection route, intramuscular route)Quinidine (Oral route, injection route, intramuscular route)
Oral route(Tablet;Tablet, Extended Release). Active antiarrhythmic therapy has resulted in increased mortality; the risk of active therapy is probably greatest in patients with structural heart disease. In a meta-analysis, the mortality associated with the use of quinidine was more than 3 times as great as the mortality associated with the use of placebo. Another meta-analysis showed that in patients with various non-life-threatening ventricular arrhythmias, the mortality associated with the use of quinidine was consistently greater than that associated with the use of alternative antiarrhythmics .. Oral route(Tablet, Extended Release). Many trials of antiarrhythmic therapy for non-life-threatening arrhythmias have resulted in increased mortality; the risk of therapy is probably greatest in patients with structural heart disease. In the case of quinidine used to prevent or defer recurrence of atrial flutter or fibrillation, meta-analysis data have shown that the mortality associated with the use ...
https://www.allinahealth.org/CCS/doc/Thomson%20Detailed%20Drugs/47/601191.htm
Quinidine - Side Effects, Uses, Dosage, Overdose, Pregnancy, Alcohol | RxWikiQuinidine - Side Effects, Uses, Dosage, Overdose, Pregnancy, Alcohol | RxWiki
Quinidine - Get up-to-date information on Quinidine side effects, uses, dosage, overdose, pregnancy, alcohol and more. Learn more about Quinidine
https://www.rxwiki.com/quinidine/
QuinidineQuinidine
Quinidine is an alkaloid obtained from various species of Cinchona or its hybrids, from Remijia pedunculata, or from quinine. Quinidine is the dextror
http://www.brainkart.com/article/Quinidine_28073/
Quinidine injection | StayWell Health Library | MainQuinidine injection | StayWell Health Library | Main
Quinidine injection What is this medicine? QUINIDINE (KWIN i deen) is an antiarrhythmic drug. It helps make your heart beat regularly. This medicine also helps to slow rapid heartbeats. It is also used to treat certain types of malaria. How should I use this medicine? This medicine is for injection into a muscle or infusion into a vein. It is given by a health care professional in a hospital or clinic setting. Talk to your pediatrician regarding the use of this medicine in children. Special care may be ...
http://www.lifebridgehealth.org/Main/HealthLibrary/21435.aspx?email=1
Plus itPlus it
Several agents can decrease or increase currents through ion channels, depending on the voltage clamp protocols. This is the case for the dihydropyridine Ca channel antagonists/agonists (Hess et al., 1984). For K channels, several such cases have been described. These include the effects of almokalant on the rapid component of delayed rectifier (IKr) K channels in rabbit ventricular myocytes (Carmeliet, 1993), azimilide (AZ) on the slow component of delayed rectifier channels in guinea pig cardiac myocytes (Davies et al., 1996), and quinidine on Kv1.2 expressed inXenopus oocytes (Tseng et al., 1996). The agonist effects (increasing current amplitudes) of all these K channel drugs manifest one common feature: they are associated with a hyperpolarizing shift in the voltage dependence of channel activation, suggesting that drug-induced modifications of channels gating processes may be involved. This is supported by the observations that the agonist effect of quinidine on Kv1.2 is accompanied by a ...
http://jpet.aspetjournals.org/content/291/3/1324
Effects of Temperature, Na and K Concentration and Quinidine on Transmembrane Flux of K42 and Incidence of Atrial Fibrillation ...Effects of Temperature, Na and K Concentration and Quinidine on Transmembrane Flux of K42 and Incidence of Atrial Fibrillation ...
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http://circres.ahajournals.org/content/6/4/516
DailyMed - Search Results for QUINIDINE SULFATEDailyMed - Search Results for QUINIDINE SULFATE
Due to inconsistencies between the drug labels on DailyMed and the pill images provided by RxImage, we no longer display the RxImage pill images associated with drug labels. We anticipate reposting the images once we are able identify and filter out images that do not match the information provided in the drug labels. ...
https://dailymed.nlm.nih.gov/dailymed/search.cfm?labeltype=all&query=QUINIDINE+SULFATE
Reply to: Amiodarone and quinidine for postoperative atrial arrhythmias (J Thorac Cardiovasc Surg 1990;99:942) - Semantic...Reply to: Amiodarone and quinidine for postoperative atrial arrhythmias (J Thorac Cardiovasc Surg 1990;99:942) - Semantic...
Semantic Scholar extracted view of Reply to: Amiodarone and quinidine for postoperative atrial arrhythmias (J Thorac Cardiovasc Surg 1990;99:942) by H F McAlister et al.
https://www.semanticscholar.org/paper/Reply-to-Amiodarone-and-quinidine-for-postoperativ-McAlister-Luke/b320be993da4150607d9b4ec3b7faa453f61f59b
Quinidine | Colorado PROFILESQuinidine | Colorado PROFILES
An optical isomer of quinine, extracted from the bark of the CHINCHONA tree and similar plant species. This alkaloid dampens the excitability of cardiac and skeletal muscles by blocking sodium and potassium currents across cellular membranes. It prolongs cellular ACTION POTENTIALS, and decreases automaticity. Quinidine also blocks muscarinic and alpha-adrenergic neurotransmission ...
https://profiles.ucdenver.edu/display/204377
quinidine - definition and meaningquinidine - definition and meaning
quinidine: A colorless crystalline alkaloid, C20H24N2O2, resembling quinine and used in treating malaria and certain heart disorders.
https://www.wordnik.com/words/quinidine
Quinidine Tablets - FDA prescribing information, side effects and usesQuinidine Tablets - FDA prescribing information, side effects and uses
Quinidine Tablets official prescribing information for healthcare professionals. Includes: indications, dosage, adverse reactions, pharmacology and more.
https://www.drugs.com/pro/quinidine-tablets.html
quinidine | Ligand page | IUPHAR/BPS Guide to PHARMACOLOGYquinidine | Ligand page | IUPHAR/BPS Guide to PHARMACOLOGY
The IUPHAR/BPS Guide to Pharmacology. quinidine ligand page. Quantitative data and detailed annnotation of the targets of licensed and experimental drugs.
http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?tab=refs&ligandId=2342
MEDLINE - Resultado p gina 1MEDLINE - Resultado p gina 1
AIMS: Short QT syndrome (SQTS) is an inherited disorder associated with abnormally abbreviated QT intervals and an increased incidence of atrial and ventricular arrhythmias. SQT1 variant (linked to the rapid delayed rectifier potassium channel current, IKr) of SQTS, results from an inactivation-attenuated, gain-of-function mutation (N588K) in the KCNH2-encoded potassium channels. Pro-arrhythmogenic effects of SQT1 have been well characterized, but less is known about the possible pharmacological antiarrhythmic treatment of SQT1. Therefore, this study aimed to assess the potential effects of E-4031, disopyramide and quinidine on SQT1 using a mathematical model of human ventricular electrophysiology. METHODS: The ten Tusscher et al. biophysically detailed model of the human ventricular action potential (AP) was modified to incorporate IKr Markov chain (MC) formulations based on experimental data of the kinetics of the N588K mutation of the KCNH2-encoded subunit of the IKr channels. The modified ...
http://bases.bireme.br/cgi-bin/wxislind.exe/iah/online/?IsisScript=iah/iah.xis&nextAction=lnk&base=MEDLINE&lang=p&format=detailed.pft&indexSearch=EX&exprSearch=D03.383.725.227
Plus itPlus it
Xenobiotics, such as amiloride, MPP+, and quinine, that are transported at low rates by the mammalian luminal OC exchanger and compete for the OC binding site on the carrier, are known to trans-inhibit OC transport (Lazaruk and Wright, 1990;Rafizadeh et al., 1986; Sokol et al., 1987;Wright and Wunz, 1987). Likewise, several xenobioticstrans-inhibited TEA efflux from avian renal BBMV (fig. 3). The relatively low transport capacity for these and other xenobiotic substrates may be a direct, but adverse consequence of the high-affinity binding of the substrate to the exchanger. Kinetic analyses conducted on rabbit renal BBMV determined that amiloride and quinidine were competitive inhibitors of OC/H+exchange (Wright and Wunz, 1987; Ott et al., 1991). Preliminary kinetic analysis suggested that the inhibitory potency and low transport efficacy of amiloride, procainamide and quinidine may possibly involve allosteric interactions; however, based on these preliminary data, it cannot be said whether ...
http://jpet.aspetjournals.org/content/287/3/944
More Archives - Mysasa.inMore Archives - Mysasa.in
This is atype of cohort study called a longitudinal study. Improved detection of microbial ureteral stent col-onisation by sonication. Further frequentclinical features are pain and immobility of the joint. Thesynthesis of angiotensin II can be attenuated by inhibiting reninand angiotensin converting enzymes. This is only partly an academic exercise; it will ultimatelyalso be a very personal task. This is in contrast to other models that focus on Treg-secretedadenosine, which have the capability to inhibit donor anti-tumor effector T cells (Thompson2013). Effects of quinidine on the sodium channel resultsin moderate conduction slowing ...
http://mysasa.in/product-category/bags-luggage/more-bags-luggage/
Most recent papers with the keyword Long qt | Read by QxMDMost recent papers with the keyword Long qt | Read by QxMD
BACKGROUND: Short QT syndrome (SQTS) is a rare and life-threatening arrhythmogenic syndrome characterized by abbreviated repolarization. Hydroquinidine (HQ) prolongs the QT interval in SQTS patients, although whether it reduces cardiac events is currently unknown. OBJECTIVES: This study investigated whether long-term treatment with HQ reduces the occurrence of life-threatening arrhythmic events (LAE) (cardiac arrest or sudden cardiac death) in SQTS patients. METHODS: In this cohort study on consecutive SQTS patients, 2 analyses were performed: 1) a matched-period analysis for the occurrence of LAE in 17 SQTS patients who received long-term HQ; and 2) a comparison of the annual incidence of LAE off- and on-HQ in 16 SQTS patients who survived a cardiac arrest ...
https://www.readbyqxmd.com/keyword/2368
Quinidine - Registration Dossier - ECHAQuinidine - Registration Dossier - ECHA
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice ...
https://echa.europa.eu/sv/registration-dossier/-/registered-dossier/16705/4/14
Quin-G Side Effects in Detail - Drugs.comQuin-G Side Effects in Detail - Drugs.com
Learn about the potential side effects of Quin-G (quinidine). Includes common and rare side effects information for consumers and healthcare professionals.
https://www.drugs.com/sfx/quin-g-side-effects.html
Quinidine sulfate | definition of quinidine sulfate by Medical dictionaryQuinidine sulfate | definition of quinidine sulfate by Medical dictionary
Looking for online definition of quinidine sulfate in the Medical Dictionary? quinidine sulfate explanation free. What is quinidine sulfate? Meaning of quinidine sulfate medical term. What does quinidine sulfate mean?
https://medical-dictionary.thefreedictionary.com/quinidine+sulfate
Anticholinergic effects of disopyramide and quinidine on guinea pig myocardium. Mediation by direct muscarinic receptor...Anticholinergic effects of disopyramide and quinidine on guinea pig myocardium. Mediation by direct muscarinic receptor...
We studied the interaction of disopyramide, quinidine, and procainamide with cardiac muscarinic receptors. In electrophysiological experiments, the effects of disopyramide, quinidine, procainamide, and atropine were determined on spontaneously depolarizing guinea pig right atria (GPRA) both in the presence and absence of pharmacologically induced (physostigmine) cholinergic stimulation. All four agents demonstrated a concentration-dependent antagonism of the negative chronotropic effects of physostigmine. The order of anticholinergic potency was atropine greater than disopyramide greater than quinidine greater than procainamide. The ability of disopyramide to antagonize the physostigmine induced slowing was stereoselective, (+)disopyramide greater than (-)disopyramide. In contrast, the ability of quinidine to antagonize the negative chronotropic effects of physostigmine was non-stereoselective, quinidine = quinine. In parallel experiments, we studied the ability of disopyramide, quinidine, ...
http://circres.ahajournals.org/content/47/6/855
dextromethorphan hydrobromide; quinidine sulfate: Pharmaceutical manufacturers, suppliers, and distributorsdextromethorphan hydrobromide; quinidine sulfate: Pharmaceutical manufacturers, suppliers, and distributors
Generic DEXTROMETHORPHAN HYDROBROMIDE; QUINIDINE SULFATE availability. Has a generic version of DEXTROMETHORPHAN HYDROBROMIDE; QUINIDINE SULFATE been approved? Find suppliers, manufacturers, and packagers
https://www.drugpatentwatch.com/p/supplier/dextromethorphan+hydrobromide%3B+quinidine+sulfate/i/
Quinidine - WikipediaQuinidine - Wikipedia
Quinidine is a pharmaceutical agent that acts as a class I antiarrhythmic agent (Ia) in the heart. It is a stereoisomer of quinine, originally derived from the bark of the cinchona tree. The drug causes increased action potential duration, as well as a prolonged QT interval. Quinidine is used as a class I antiarrhythmic agent, that is, to prevent ventricular arrhythmias. It is also used to maintain sinus rhythm after cardioversion of atrial fibrillation and to treat short QT syndrome. A combination of dextromethorphan and quinidine has been shown to alleviate symptoms of easy laughing and crying (pseudobulbar affect) in patients with amyotrophic lateral sclerosis and multiple sclerosis. This drug is marketed as Nuedexta in the United States. Intravenous quinidine is also indicated for treatment of Plasmodium falciparum malaria. However, quinidine is not considered the first-line therapy for P. falciparum. The recommended treatments for P. falciparum malaria, according to the Toronto Notes 2008, ...
https://en.wikipedia.org/wiki/Quinidine
IJMS | Free Full-Text | Stereoselective Blockage of Quinidine and Quinine in the hERG Channel and the Effect of Their Rescue...IJMS | Free Full-Text | Stereoselective Blockage of Quinidine and Quinine in the hERG Channel and the Effect of Their Rescue...
Diastereoisomers of quinidine and quinine are used to treat arrhythmia and malaria, respectively. It has been reported that both drugs block the hERG (human ether-a-go-go-related gene) potassium channel which is essential for myocardium repolarization. Abnormality of repolarization increases risk of arrhythmia. The aim of our research is to study and compare the impacts of quinidine and quinine on hERG. Results show that both drugs block the hERG channel, with quinine 14-fold less potent than quinidine. In addition, they presented distinct impacts on channel dynamics. The results imply their stereospecific block effect on the hERG channel. However, F656C-hERG reversed this stereoselectivity. The mutation decreases affinity of the two drugs with hERG, and quinine was more potent than quinidine in F656C-hERG blockage. These data suggest that F656 residue contributes to the stereoselective pocket for quinidine and quinine. Further study demonstrates that both drugs do not change hERG protein levels. In
http://www.mdpi.com/1422-0067/17/10/1648
007831: Quinidine, Serum or Plasma | LabCorp007831: Quinidine, Serum or Plasma | LabCorp
This Class 1A drug is useful in both supraventricular and ventricular arrhythmias. It major uses are to maintain sinus rhythm after conversion of atrial flutter or fibrillation, to prevent ventricular tachycardia, and for long-term prophylaxis in patients with AV nodal reentrant tachycardia and automatic atrial tachycardia. Quinidine also has been used to prevent symptomatic premature supraventricular and ventricular complexes. Because it slows conduction and prolongs the refractory period of the accessory pathway and suppresses automaticity of ectopic pacemakers, quinidine may prevent recurrences of paroxysmal supraventricular tachycardia caused by reentry over a concealed pathway or AV reciprocating tachycardia associated with the Wolff-Parkinson-White syndrome. It also may slow the ventricular response to atrial flutter or fibrillation in the preëxcitation syndrome. Quinidine is often preferred to procainamide for long-term therapy because elevated antinuclear antibody titers and ...
https://www.labcorp.com/test-menu/34056/quinidine-serum-or-plasma
Real Story: Karen | NUEDEXTA® (dextromethorphan HBr 20 mg and quinidine sulfate 10 mg) capsulesReal Story: Karen | NUEDEXTA® (dextromethorphan HBr 20 mg and quinidine sulfate 10 mg) capsules
Finally, Karen found a name for the symptoms in an MS forum: PseudoBulbar Affect, also known as PBA-sudden, frequent, uncontrollable episodes of crying and/or laughing that are exaggerated and/or dont match how the person feels. And in 2009, she and Ross heard about a clinical trial for a drug being studied for the treatment of PBA.. I wanted to feel comfortable and to stop worrying about the crying and laughing episodes. I had to do something, says Karen.. ...
https://www.nuedexta.com/real-stories-karen
Real Story: Karen | NUEDEXTA® (dextromethorphan HBr 20 mg and quinidine sulfate 10 mg) capsulesReal Story: Karen | NUEDEXTA® (dextromethorphan HBr 20 mg and quinidine sulfate 10 mg) capsules
Finally, Karen found a name for the symptoms in an MS forum: PseudoBulbar Affect, also known as PBA-sudden, frequent, uncontrollable episodes of crying and/or laughing that are exaggerated and/or dont match how the person feels. And in 2009, she and Ross heard about a clinical trial for a drug being studied for the treatment of PBA.. I wanted to feel comfortable and to stop worrying about the crying and laughing episodes. I had to do something, says Karen.. ...
https://www.nuedexta.com/index.php/real-stories-karen
Nuedexta (dextromethorphan HBr and quinidine sulfate) PseudoBulbar Affect PBA Treatment | Neurology | TheSocialMedworkNuedexta (dextromethorphan HBr and quinidine sulfate) PseudoBulbar Affect PBA Treatment | Neurology | TheSocialMedwork
How and where to buy Nuedexta: You can order Nuedexta from TheSocialMedwork if the drug has not been approved or is not available in your country.
https://thesocialmedwork.com/shop/nuedexta-dextromethorphan-quinidine
QDR3 - Quinidine resistance protein 3 - Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Bakers yeast) - QDR3 gene &...QDR3 - Quinidine resistance protein 3 - Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Bakers yeast) - QDR3 gene &...
Multidrug resistance transporter involved in resistance and adaptation to quinidine and to the herbicide barban (4-chloro-2-butynyl [3-chlorophenyl] carbamate).
http://www.uniprot.org/uniprot/P38227
1435-55-8/Hydroquinidine (8a,9R)-10,11-Dihydro-6-methoxycinchonan-9-ol1435-55-8/Hydroquinidine (8a,9R)-10,11-Dihydro-6-methoxycinchonan-9-ol
Gemcitabine、Irinotecan、Trifluridine、Trifluorothymine、Atracurium besylate、Calcium folinatc、Folinic acid、Mesna、Imatinib mesylate
http://www.orgsynchem.com/detailproe.php?id=2591
Drug-Induced Thrombocytopenia<...Drug-Induced Thrombocytopenia<...
TY - CHAP. T1 - Drug-Induced Thrombocytopenia. AU - Mitchell, W. Beau. AU - Bennett, Carolyn M.. PY - 2013/6/11. Y1 - 2013/6/11. UR - http://www.scopus.com/inward/record.url?scp=84903503927&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=84903503927&partnerID=8YFLogxK. U2 - 10.1016/B978-0-12-397164-7.00099-9. DO - 10.1016/B978-0-12-397164-7.00099-9. M3 - Chapter. AN - SCOPUS:84903503927. SN - 9780123971647. SP - 647. EP - 650. BT - Transfusion Medicine and Hemostasis. PB - Elsevier Inc.. ER - ...
https://einstein.pure.elsevier.com/en/publications/drug-induced-thrombocytopenia
Drug Offers Control for Laughing/Crying Outbursts | Quest Magazine OnlineDrug Offers Control for Laughing/Crying Outbursts | Quest Magazine Online
Zenvia (formerly called Neurodex) is a combination of two drugs, dextromethorphan and quinidine. Two dosage formulations were used in the trial: 30 milligrams of dextromethorphan combined with 10 milligrams of quinidine and 20 milligrams of dextromethorphan combined with 10 milligrams of quinidine. Avanir reports both dosages significantly reduced episodes of PBA compared to a placebo. The drug was generally safe and well tolerated. ...
http://quest.mda.org/news/drug-offers-control-laughingcrying-outbursts
BioCentury - AVP-786: Phase I dataBioCentury - AVP-786: Phase I data
Data from 36 healthy volunteers in the first stage of a double-blind, crossover Phase I trial showed that AVP-786 plus low-dose quinidine had a comparable pharmacokinetic, safety and tolerability profile to that of AVP-923, a combination product containing dextromethorphan and a higher dose of quinidine (10 mg) than that given with AVP-786. Avanir said AVP-786 and AVP-923 contained the same amount of dextromethorphan in the trial, but declined to disclose the actual dose.
https://www.biocentury.com/bc-week-review/clinical-news/clinical-results/2013-02-18/avp-786-phase-i-data
Quinidine tabletsQuinidine tablets
Visit your doctor or health care professional for regular checks on your progress. Wear a medical ID bracelet or chain, and carry a card that describes your disease and details of your medicine and dosage times.. Check your blood pressure and pulse rate regularly. Ask your health care professional what your blood pressure and pulse rate should be, and when you should contact him or her. Your doctor or health care professional also may schedule regular blood tests and electrocardiograms to check your progress.. You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medicine affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells. Alcohol may interfere with the effect of this medicine. Avoid alcoholic drinks.. This medicine can make you more sensitive to the sun. Keep out of the sun. If you cannot avoid being in the sun, wear protective clothing and ...
http://healthlibrary.metroplus.org/Library/DiseasesConditions/Adult/Cardiovascular/121,891
Safety and Efficacy of AVP-923 in PBA Patients With ALS or MS - Study Results - ClinicalTrials.govSafety and Efficacy of AVP-923 in PBA Patients With ALS or MS - Study Results - ClinicalTrials.gov
AVP-923 capsules containing 30 mg dextromethorphan (DM) and 10 mg quinidine (Q) taken orally once daily for 1 week and twice daily for 11 additional consecutive weeks for a 12 week double-blind (DB) period. Subjects who completed the DB period of this treatment arm could begin an optional 12 week open-label extension (OLE) period taking AVP-923 capsule containing 30 mg DM and 10 mg Q twice daily ...
https://clinicaltrials.gov/ct2/show/results/NCT00573443?sect=Xc0156&view=results
Safety and Efficacy of AVP-923 in PBA Patients With ALS or MS - Study Results - ClinicalTrials.govSafety and Efficacy of AVP-923 in PBA Patients With ALS or MS - Study Results - ClinicalTrials.gov
AVP-923 capsules containing 30 mg dextromethorphan (DM) and 10 mg quinidine (Q) taken orally once daily for 1 week and twice daily for 11 additional consecutive weeks for a 12 week double-blind (DB) period. Subjects who completed the DB period of this treatment arm could begin an optional 12 week open-label extension (OLE) period taking AVP-923 capsule containing 30 mg DM and 10 mg Q twice daily ...
https://clinicaltrials.gov/ct2/show/results/NCT00573443?sect=X01&view=results
Plus itPlus it
SCH 66712 [5-fluoro-2-[4-[(2-phenyl-1H-imidazol-5-yl)methyl]-1-piperazinyl]pyrimidine] caused a time- and NADPH-dependent loss of CYP2D6 activity. The inactivation of human liver (HL) microsomal dextromethorphanO-demethylase activity, a prototype marker for CYP2D6, was characterized by a K I of 4.8 μM and a maximal rate constant of inactivation (k inact) of 0.14 min−1. The inactivation of the recombinant CYP2D6 in Supersomes (r-CYP2D6) was characterized by a K I of 0.55 μM and ak inact of 0.32 min−1. Extensive dialysis of the SCH 66712-inhibited enzyme failed to restore the activity to control levels (dialyzed reaction mixture lacking SCH 66712) for both HL microsomes and r-CYP2D6. Addition of glutathione, superoxide dismutase, or mannitol to the reaction mixture failed to protect CYP2D6 against SCH 66712-NADPH-catalyzed inactivation. Addition of quinidine, a reversible inhibitor of CYP2D6, to a preincubation mixture consisting of SCH 66712, HL microsomes, or Supersomes and NADPH partially ...
https://dmd.aspetjournals.org/content/29/6/863
cost of Nuedextacost of Nuedexta
Quinidine, which is an ingredient in Nuedexta, has been known to cause hepatitis.. Common Side Effects Of Nuedexta. The most common side effects to be aware of are diarrhea, cough, dizziness, vomiting, swelling of the feet and ankles, weakness and more. Be sure to call your doctor immediately if youre unsure of any possible side effect. Talking to your physician will rule out the possibility of an allergic or potentially fatal reaction.. Nuedexta cost. Your cost for Nuedexta can vary depending on insurance coverage and where you purchased the drug. According to a price guide from drugs.com, a 60 capsule count could cost $809 dollars using a discount card. Other locations offer the same supply at just under that price when you purchase the medicine with a coupon. The average retail price without any discounts or coupons comes in at just under $900 dollars.. If You Cant Afford Your Medication. If you cant afford your co-pay or your medicine, call Nuedexta and discuss the options for your ...
http://www.congareepharmacy.com/tag/cost-of-nuedexta/
Platelet measurements versus discharge diagnoses for identification of patients with potential drug-induced thrombocytopenia: a...Platelet measurements versus discharge diagnoses for identification of patients with potential drug-induced thrombocytopenia: a...
TY - JOUR. T1 - Platelet measurements versus discharge diagnoses for identification of patients with potential drug-induced thrombocytopenia. T2 - a cross-sectional study in the Netherlands. AU - ten Berg, Maarten J. AU - van Solinge, Wouter W. AU - van den Bemt, Patricia M L A. AU - Huisman, Albert. AU - Schobben, Alfred F A M. AU - Egberts, Toine C G. PY - 2009. Y1 - 2009. N2 - BACKGROUND: In pharmacoepidemiological studies on the risk of drug-induced blood dyscrasias, including drug-induced thrombocytopenia (DIT), hospital discharge diagnoses have been used to identify potential cases. One of the possible limitations of discharge diagnoses is that due to incomplete registration not all potential cases are identified, which may limit statistical power. Clinical laboratory data have been suggested as a data type that is potentially more sensitive for identifying potential cases of adverse drug reactions than discharge diagnoses.OBJECTIVE: To compare the number of patients with potential DIT ...
https://research.rug.nl/en/publications/platelet-measurements-versus-discharge-diagnoses-for-identificati
October | 2013 | Mdm2 InhibitorOctober | 2013 | Mdm2 Inhibitor
Effects of antiarrhythmic drugs on HCN4 channel currents in HEK293 cells Effects of type Ia antiarrhythmic drugs, quinidine, disopyramide, and cibenzoline, on the HCN4 channel current were examined in HEK293 cells. Quinidine developed a simple reduction of the HCN4 channel current at a concentration of 30 uM. The assessed IC50 value of quinidine for inhibiting the HCN4 channel current purchase Celecoxib was 78. 3 uM, which was greater than the therapeutic concentration of quinidine. Cibenzoline and disopyramide also inhibited the HCN4 channel current weakly, with calculated IC50 values of 46. 249 and 8 uM, respectively, which were both more than the therapeutic concentrations. Ramifications of class Ib anti-arrhythmic medications, aprindine, and lidocaine, mexiletine, to the HCN4 channel current were also examined in HEK293 cells. Lidocaine at a concentration Organism of 30 uM inhibited the HCN4 channel current, specially at hyperpolarizing currents below 100 mV. The inhibitory effect of ...
https://mdmsignaling.com/2013/10/
Nuedexta (dextromethorphan/quinidine) dosing, indications, interactions, adverse effects, and moreNuedexta (dextromethorphan/quinidine) dosing, indications, interactions, adverse effects, and more
Medscape - Pseudobulbar affect dosing for Nuedexta dextromethorphan/quinidine), frequency-based adverse effects, comprehensive interactions, contraindications, pregnancy & lactation schedules, and cost information.
https://reference.medscape.com/drug/nuedexta-dextromethorphan-quinidine-999608
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1)Review elementary knowledge related to myocardium physiology: action potential phases and ions across membrane. Automaticity, conductivity, excitability, absolute refractory period, effecitive refractory period, action potential duration, reentry, mechanism of arrhythmias. (2)The classification of antiarrhythmic drugs: Na+ channel blocking drugs(Ⅰa): quinidine: decrease membrane permeability to Na+, also decrease membrane permeability to K+, Ca2+, decrease automatioty, conduction speed, prolong effective refractory period, decrease cardiac contractity, ECG changes, used to treat atrial fibillation, atrial flutter, side effects: syncope, precautions in using qunidine. Procainamide: the difference with quinidine. Ⅰb: lidocaine, promote K+ efflux, and inhibit Na+ influx, mainly affect on purkinjes system, decrease automaticity, enhance the conduction speed of damaged fiber, shortening refractory period and duration of action potential. Used to treat ventricular arrhythmias. Pharmacokinetics ...
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Atrial and AV-nodal physiology in horses: Electrophysiologic and echocardiographic characterization and pharmacologic effects...Atrial and AV-nodal physiology in horses: Electrophysiologic and echocardiographic characterization and pharmacologic effects...
Atrial fibrillation (AF) is considered the most common arrhythmia affecting exercise performance in horses. Quinidine is an effective therapy for conversion of AF to sinus rhythm, but treatment is associated with a number of adverse clinical effects. Furthermore, residual electrical and mechanical abnormalities of the equine atria may account for the recurrence of AF following successful therapy. Relative to these issues, we sought to better understand the physiology of the in vivo equine atria and the associated sinoatrial and atrioventricular (AV) nodal tissues. In treating horses with AF using the drug quinidine, a common adverse effect is marked acceleration of the ventricular response rate prompting early discontinuation of treatment. Diltiazem effectively controls ventricular response to AF in other species, but has not been evaluated in horses. In our first series of experiments we studied the pharmacodynamic and pharmacokinetic effects of the calcium channel blocker diltiazem on the ...
http://www.openthesis.org/documents/Atrial-AV-nodal-physiology-in-542823.html
Genetic variations in ABCB1 and CYP3A5 as well as sex influence quinine disposition among UgandansGenetic variations in ABCB1 and CYP3A5 as well as sex influence quinine disposition among Ugandans
Abstract: Quinine is one of the most effective antimalarial drugs, although its clinical use is limited as a result of its narrow safety margin. Quinine is a substrate of the polymorphic p-glycoprotein and CYP3A4/3A5. This study aimed to examine the effects of genetic variations in ABCB1 and CYP3A5 genes, sex, demographic, and biochemical variables (serum albumin, creatinine, alanine aminotransferase and albumin) on quinine disposition among Ugandans. Quinine (600 mg) was orally administered to 140 healthy volunteers. Quinine and its metabolite 3-hydroxyquinine concentrations were determined from 16-hour postdose plasma by high-performance liquid chromatography. CYP3A5 activity was measured using quinine/3-hydroxyquinine ratio (metabolic ratio). Genotyping for a total of 20 single nucleotide polymorphisms in ABCB1 (n = 13) and CYP3A5 (n = 7) was done using Taqman and minisequencing on microarray. There were 20.5- and 13-fold variations in body weight adjusted plasma quinine concentrations (mean ...
http://makir.mak.ac.ug/handle/10570/645
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Brugada syndromeBrugada syndrome
Quinidine is an antiarrhythmic drug that may reduce the chance of serious abnormal heart rhythms occurring in some people with ... Yang F, Hanon S, Lam P, Schweitzer P (April 2009). "Quinidine revisited". The American Journal of Medicine. 122 (4): 317-21. ... Belhassen B, Glick A, Viskin S (September 2004). "Efficacy of quinidine in high-risk patients with Brugada syndrome". ... while quinidine may be used longer term. Testing people's family members may be recommended. The condition affects between 1 ...
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QuinineQuinine
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RitonavirRitonavir
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DisopyramideDisopyramide
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Category:Alkene derivativesCategory:Alkene derivatives
Text is available under the Creative Commons Attribution-ShareAlike License; additional terms may apply. By using this site, you agree to the Terms of Use and Privacy Policy. Wikipedia® is a registered trademark of the Wikimedia Foundation, Inc., a non-profit organization ...
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AlkaloidAlkaloid
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Antimalarial medicationAntimalarial medication
Quinimax and quinidine are the two most commonly used alkaloids related to quinine in the treatment or prevention of malaria. ... Quinidine is a direct derivative of quinine. It is a distereoisomer, thus having similar anti-malarial properties to the parent ... Quinidine is recommended only for the treatment of severe cases of malaria. Warburg's tincture was a febrifuge developed by ... Quinimax is a combination of four alkaloids (quinine, quinidine, cinchoine and cinchonidine). This combination has been shown ...
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Schedule HSchedule H
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While procainamide and quinidine may be used in the conversion of atrial fibrillation to normal sinus rhythm, they should only ... Class Ia agents include quinidine, procainamide and disopyramide. Class Ib antiarrhythmic agents are sodium channel blockers. ... because procainamide and quinidine can increase the conduction through the AV node and may cause 1:1 conduction of atrial ...
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ChlorpromazineChlorpromazine
Quinidine may interact with chlorpromazine to increase myocardialdepression. Likewise it may also antagonize the effects of ... Other drugs that prolong the QT interval such as quinidine, verapamil, amiodarone, sotalol and methadone may also interact with ...
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TetrandrineTetrandrine
It has a quinidine-like anti-arrhythmic effect. It is isolated from the plant Stephania tetrandra, and other Chinese and ...
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Procainamide, quinidine and disopyramide are Class Ia agents. Class 1b drugs lengthen phase 3 repolarization. They include ...
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Two more key alkaloids, quinidine and cinchonidine, were later identified and it became a routine in quinology to examine the ... The bark contains alkaloids, including quinine and quinidine. Cinchona is the only economically practical source of quinine, a ... Cinchona alkaloids include: cinchonine and cinchonidine (stereoisomers with R1 = vinyl, R2 = hydrogen) quinine and quinidine ( ...
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... taken with quinidine was found to produce respiratory depression, indicative of central opioid action. Loperamide ... Concurrent administration of P-glycoprotein inhibitors such as quinidine potentially allows loperamide to cross the blood-brain ... Common P-glycoprotein inhibitors include quinidine, ritonavir, and ketoconazole. Loperamide is capable of decreasing the ...
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DextrorphanDextrorphan
Relevance to dextromethorphan/quinidine (Nuedexta®) clinical use". Pharmacol. Ther. 164: 170-82. doi:10.1016/j.pharmthera. ...
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ProcainamideProcainamide
Due to the loss of Indonesia in World War II, the source for cinchona alkaloids, a precursor of quinidine, was reduced. This ... As a result, procaine was discovered, which has similar cardiac effects as quinidine. In 1936 it was found by Mautz that by ... These were the cardiac glycosides, quinidine, propranolol, lidocaine and diphenylhydantoin. In January 1996, extended release ... but it had the same toxicity profile as quinidine, and it could cause systemic lupus erythematosus-like syndrome. These ...
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Woodhall B, Sealy WC, Hall KD, Floyd WL (July 1960). "Craniotomy under conditions of quinidine-protected cardioplegia and ... Woodhall B, Sealy WC, Hall KD, Floyd WL (July 1960). "Craniotomy under conditions of quinidine-protected cardioplegia and ... Woodhall B, Sealy WC, Hall KD, Floyd WL (July 1960). "Craniotomy under conditions of quinidine-protected cardioplegia and ...
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Quinidine, reduces urinary excretion of quinidine, hence increasing the potential for toxicity. Salicylates, potential for ...
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Drugs such as quinidine may be both reverse use dependent and use dependent. Examples of calcium-activated channel blockers ... Reverse use dependent drugs that slow heart rate (such as quinidine) can be less effective at high heart rates. The ... such as quinidine) are more efficacious at preventing a tachyarrhythmia than converting someone into normal sinus rhythm.[ ... Bupivacaine Quinidine Fluoxetine Seproxetine (Norfluoxetine) 12-O-tetradecanoylphorbol-13-acetate (TPA) (phorbol 12-myristate ...
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quinidine synonyms, quinidine pronunciation, quinidine translation, English dictionary definition of quinidine. n. A bitter ... quinidine. Also found in: Thesaurus, Medical, Encyclopedia, Wikipedia.. Related to quinidine: quinine, Quinidine sulfate quin·i ... Quinidine - definition of quinidine by The Free Dictionary https://www.thefreedictionary.com/quinidine ... quinidine. (ˈkwɪnɪˌdiːn) n. (Pharmacology) a crystalline alkaloid drug that is an optically active diastereoisomer of quinine: ...
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quinidine definition: a colorless, crystalline alkaloid, CHNO, isomeric with and resembling quinine, extracted from cinchona ... quinidine. noun. A bitter alkaloid, C20H24N2O2, that is a stereoisomer of quinine, used in the form of its salts to treat ... quinidine. quin·i·dine. a colorless, crystalline alkaloid, CHNO, isomeric with and resembling quinine, extracted from cinchona ... The sulphate of quinine used in medicine may contain up to 3% of cinchonidine, but should be free from cinchonine, quinidine ...
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Dextromethorphan And Quinidine (Oral Route) Precautions - Mayo ClinicDextromethorphan And Quinidine (Oral Route) Precautions - Mayo Clinic
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Quinidine) may treat, side effects, dosage, drug interactions, warnings, patient labeling, reviews, and related medications ... Non-interactions of quinidine with other drugs: Quinidine has no clinically significant effect on the pharmacokinetics of ... Non-interactions of quinidine with other drugs: Quinidine has no clinically significant effect on the pharmacokinetics of ... Quinidine is not metabolized by cytochrome P 450 IID 6 , but therapeutic serum levels of quinidine inhibit the action of ...
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Dextromethorphan and Quinidine | Memorial Sloan Kettering Cancer CenterDextromethorphan and Quinidine | Memorial Sloan Kettering Cancer Center
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Quinidine - Registration Dossier - ECHAQuinidine - Registration Dossier - ECHA
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https://echa.europa.eu/sv/registration-dossier/-/registered-dossier/16705/4/14
Quinidine crystallized, ≥98.0% (dried material, NT) | Sigma-AldrichQuinidine crystallized, ≥98.0% (dried material, NT) | Sigma-Aldrich
Quinidine crystallized, ,=98.0% (dried material, NT); CAS Number: 56-54-2; Linear Formula: C20H24N2O2; find related products, ... Quinidine is an isomer of quinine. Application Quinidine may be used in the preparation of O-trimethylsilylquinidine by ... HPLC Analysis of Quinidine and Trace Impurity on Discovery® HS F5 From our library of Articles, Sigma-Aldrich presents HPLC ... UHPLC Analysis of Quinidine and Metabolite on Titan™ C18 From our library of Articles, Sigma-Aldrich presents UHPLC Analysis of ...
https://www.sigmaaldrich.com/catalog/product/aldrich/22600?lang=en®ion=US
Quinidine injection | StayWell Health Library | MainQuinidine injection | StayWell Health Library | Main
Quinidine injection What is this medicine? QUINIDINE (KWIN i deen) is an antiarrhythmic drug. It helps make your heart beat ... Quinidine injection. What is this medicine?. QUINIDINE (KWIN i deen) is an antiarrhythmic drug. It helps make your heart beat ... an unusual or allergic reaction to quinidine, quinine, other medicines, foods, dyes, or preservatives ...
http://www.lifebridgehealth.org/Main/HealthLibrary/21435.aspx?email=1
Notice to Readers Availability of Parenteral Quinidine Gluconate for Treatment of Severe or Complicated MalariaNotice to Readers Availability of Parenteral Quinidine Gluconate for Treatment of Severe or Complicated Malaria
Since 1991, quinidine gluconate, a well-known and widely used class Ia anti-arrhythmic agent, has been the only parenteral ... Intravenous quinidine is indicated whenever oral therapy is not possible, in high-density infections (greater than 5% of red ... Notice to Readers Availability of Parenteral Quinidine Gluconate for Treatment of Severe or Complicated Malaria CDC has ... As newer anti-arrhythmic agents have replaced quinidine for many of its cardiac indications, some hospitals and health ...
https://www.cdc.gov/mmwr/preview/mmwrhtml/00042591.htm
Browsing by Subject QuinidineBrowsing by Subject "Quinidine"
In vivo and in vitro responses to quinine and quinidine of Plasmodium falciparum / A. Sabchareon ... [‎et al.]‎  ... Susceptibility of Plasmodium falciparum to different doses of quinine in vivo and to quinine and quinidine in vitro in relation ...
https://extranet.who.int/iris/restricted/browse?authority=Quinidine&type=mesh
quinidine - definition and meaningquinidine - definition and meaning
quinidine: A colorless crystalline alkaloid, C20H24N2O2, resembling quinine and used in treating malaria and certain heart ... What we have done is recognized that you can inhibit ones ability to metabolize dextromethorphan by adding quinidine, which is ... You could consider changing the way you are delivering quinidine which is your 2D6 inhibitor, you could consider looking at ... Quinine, a famous malaria treatment, and quinidine, an antiarrhythmic medication, are made from the bark of the cinchona tree. ...
https://www.wordnik.com/words/quinidine
Quinidine Sulfate 10 mg/mL Oral SuspensionQuinidine Sulfate 10 mg/mL Oral Suspension
... Loyd V. Allen, Jr., PhD. Professor Emeritus. College of Pharmacy, University of ... The oral suspension USP contains 90.0% to 110.0% of the labeled amount of quinidine sulfate (C20H24N2O2)2.H2SO4.2H2O. The pH of ... Discussion: Quinidine sulfate ([C20H24N2O2]2.H2SO4.2H2O, MW 782.94) occurs as fine, needlelike, white crystals frequently ... Crush the tablets to a fine powder or use the quinidine sulfate powder. Add about 25 mL of Ora-Plus, and mix to form a smooth ...
https://www.uspharmacist.com/article/quinidine-sulfate-10-mg-ml-oral-suspension
Absorption of quinidine and dihydroquinidine in humans.Absorption of quinidine and dihydroquinidine in humans.
In all subjects, dihydroquinidine was absorbed to a lesser extent than quinidine. On the basis of comparative AUC pu to 6 h ... Quinidine and dihydroquinidine were administered as the sulphates in an oral solution to seven healthy volunteers. ... Quinidine and dihydroquinidine were administered as the sulphates in an oral solution to seven healthy volunteers. In all ... 0/Drug Combinations; 1435-55-8/hydroquinidine; 56-54-2/Quinidine From MEDLINE®/PubMed®, a database of the U.S. National Library ...
http://www.biomedsearch.com/nih/Absorption-quinidine-dihydroquinidine-in-humans/7318878.html
Quinidine | Springer for Research & DevelopmentQuinidine | Springer for Research & Development
Rapid and effective response of the R222Q SCN5A to quinidine treatment in a patient with Purkinje-related ventricular ...
https://rd.springer.com/article/10.1007%2Fs40278-018-48628-4
dextromethorphan and quinidine - WellSpan Health Librarydextromethorphan and quinidine - WellSpan Health Library
Quinidine affects the way that the heart beats and is generally used in people with certain heart rhythm disorders. ... Dextromethorphan and quinidine is a combination medicine used to treat involuntary... ... if you are also taking mefloquine, quinidine, or quinine.. Do not use dextromethorphan and quinidine if you have used an MAO ... You also should not take dextromethorphan and quinidine if you are also taking mefloquine, quinidine, or quinine, or if you ...
https://www.wellspan.org/health-library/Document.aspx?id=d07707a1
Digoxin-Quinidine Interaction | Annals of Internal Medicine | American College of PhysiciansDigoxin-Quinidine Interaction | Annals of Internal Medicine | American College of Physicians
Digoxin-Quinidine Interaction J. ROBERT POWELL, PHARM.D.; PAUL E. FENSTER, M.D.; W. DAVID HAGER, M.D. ... To the editor: Mungall and associates (1) presented data which quantitate both the time course of the digoxin-quinidine ... Digoxin-Quinidine Interaction. Ann Intern Med. ;94:540. doi: 10.7326/0003-4819-94-4-540_1 ... achieve near steady state 6 days after starting quinidine therapy and that digoxin renal clearance is reduced by quinidine. We ...
http://annals.org/aim/article-abstract/694746/digoxin-quinidine-interaction
Possible inhibition of hepatic metabolism of quinidine by erythromycin.Possible inhibition of hepatic metabolism of quinidine by erythromycin.
To present and analyze a patient case illustrating a possible drug interaction between quinidine and erythromycin. METHODS: ... an increase in quinidine serum concentrations, and a possible quinidine toxicity. CONCLUSION: Serum quinidine concentrations, ... This case demonstrated a probable erythromycin-quinidine pharmacokinetic interaction that led to a decrease in quinidine ... OBJECTIVE: To present and analyze a patient case illustrating a possible drug interaction between quinidine and erythromycin. ...
http://www.biomedsearch.com/nih/Possible-inhibition-hepatic-metabolism-quinidine/7828386.html
Quinidine-lnduced Lupus Erythematosus | Annals of Internal Medicine | American College of PhysiciansQuinidine-lnduced Lupus Erythematosus | Annals of Internal Medicine | American College of Physicians
... after 5 months of quinidine therapy). Quinidine-induced antinuclear autoantibodies were of the IgM and IgG classes and were ... Quinidine-lnduced Lupus Erythematosus STERLING G. WEST, M.D.; MATTHEW McMAHON, D.O.; JOSEPH P. PORTANOVA, Ph.D. ... Upon withdrawal of quinidine therapy, the patient had prompt improvement of clinical symptoms followed by a gradual resolution ... Quinidine-lnduced Lupus Erythematosus. Ann Intern Med. 1984;100:840-842. doi: 10.7326/0003-4819-100-6-840 ...
https://annals.org/aim/article-abstract/698554/quinidine-lnduced-lupus-erythematosus
GluconateEffects of quinidineMefloquineNuedextaQuinidexDigoxinArrhythmiasMalariaConcentrationsDosageCombination of dextromethorphanToxicityKwinInhibitsDose of quinidineDavis's Drug GuideEffect of quinidineQuinine and quinidineDextromethorphan hydrobromide and quinidine sulfateTabletsAlkaloidOral quinidineTherapeuticDosesSide effects of dextromethorphanInteract with dextromethorphan and quinidineThrombocytopeniaPharmacokineticsTorsades de poinIsomer of quinine10mgAntiarrhythmic drugsSerum quinidine concentrationAntibodies recognize quinidineCombined with dextromethorphanConcentration and quinidineDrugsAtrial fibrillationAutomaticityAntiarrhythmicsForm of quinidineIncrease in quinidineMetabolism of quinidineInteraction of quinidineElimination of quinidinePseudobulbarAntigenInhibitionSodiumGrapefruit juiceConductionCYP2D6AntimalarialTake quinidine
Gluconate20
  • Quinidine comes as a tablet (quinidine sulfate) and an extended-release (long-acting) tablet (quinidine gluconate) to take by mouth. (medlineplus.gov)
  • Extended-release quinidine gluconate tablets are usually is taken every 8 to 12 hours. (medlineplus.gov)
  • Eli Lilly has discontinued manufacture of parenteral quinidine gluconate in the US, and its future availability in many countries is uncertain. (wikipedia.org)
  • The pharmaceutical manufacturer of quinidine, Eli Lilly, recently announced External that it will no longer be producing IV quinidine gluconate, but plans to continue distributing the product until the current stock expires (March 2019). (cdc.gov)
  • As of today, intravenous quinidine gluconate remains available for the treatment of severe malaria. (cdc.gov)
  • Quinidine gluconate and quinine are short burning and a rapid extinguishing (BZ2) during the preliminary test. (europa.eu)
  • According to the study report the flammability of quinidine gluconate and quinine were experimentally determined similar to the preliminary testing according to regulation 440/2008. (europa.eu)
  • During the test quinidine gluconate and quinine shortly burns and rapidly extinguish. (europa.eu)
  • CDC has received reports of two fatal cases of Plasmodium falciparum malaria in the United States in which a delay in obtaining quinidine gluconate for intravenous therapy was thought to have played a role in the patients' deaths. (cdc.gov)
  • Since 1991, quinidine gluconate, a well-known and widely used class Ia anti-arrhythmic agent, has been the only parenteral antimalarial drug available in the United States. (cdc.gov)
  • As newer anti-arrhythmic agents have replaced quinidine for many of its cardiac indications, some hospitals and health facilities have dropped quinidine gluconate from their formularies. (cdc.gov)
  • Because of this potential problem, directors of hospital drug services should take into account the essential role of quinidine gluconate in treating patients with severe and complicated malaria before removing it from their formularies. (cdc.gov)
  • Intravenous quinidine lactate and quinidine gluconate effectively control the arrhythmia in 56 to 60 per cent of the animals, but produce toxic reactions in many of them. (ahajournals.org)
  • The most effective treatment of the arrhythmia was by use of morphine followed by quinidine gluconate. (ahajournals.org)
  • If sinus rhythm isn't restored after patient has received a total of 10 mg/kg quinidine gluconate, other means of cardioversion may be considered. (thefreedictionary.com)
  • Know that quinidine gluconate is the only parenteral cinchona alkaloid antimalarial commercially available in U.S. Because newer antiarrhythmics have replaced quinidine in many cardiac uses, it may not be readily available and prescribers may not be familiar with its use. (thefreedictionary.com)
  • The last during one i went to only he gave me quinidine gluconate and netupitant. (gonzoz.com)
  • Each Quinidine gluconate for inj 80mg/ml usp 250 microgram tablet contains 250 micrograms instead of the active ingredient quinidine. (gonzoz.com)
  • Extended-release quinidine gluconate (stars with dotted line) and quinidine sulfate (squares with solid line) have slower absorption profiles, so the drug has an opportunity to distribute to tissues while absorption is occurring. (mhmedical.com)
  • Quinidine is available either as quinidine sulfate or quinidine gluconate. (medicalproductguide.com)
Effects of quinidine10
  • Because of the proarrhythmic effects of quinidine, its use with ventricular arrhythmias of lesser severity is generally not recommended, and treatment of patients with asymptomatic ventricular premature contractions should be avoided. (rxlist.com)
  • Our research demonstrated stereoselective effects of quinidine and quinine on the hERG channel, and this is the first study to explore their reversal potency on drug-induced hERG deficiency. (mdpi.com)
  • Common side effects of quinidine include diarrhea, lightheadedness, and headache. (rxwiki.com)
  • This study examined the effects of quinidine, quinine, and the quaternary quinidine derivative, quinidinium, on the conductance and activity of purified cardiac sarcoplasmic reticulum calcium release channels/ryanodine receptors (RyR) incorporated into planar lipid bilayers. (aspetjournals.org)
  • There was no stereospecificity in the effects of quinidine because the levoisomer, 100 μM quinine, produced a similar subconductance activity of the channel. (aspetjournals.org)
  • This dependency may explain why hypokalemic patients are often unresponsive to the antiarrhythmic effects of quinidine and are prone to develop cardiac rhythm disorders. (brainkart.com)
  • The depressant effects of quinidine on the cardiovascular system are most likely to occur after IV administration, and therefore, quinidine should not be employed rou-tinely in the emergency treatment of arrhythmias. (brainkart.com)
  • Effects of quinidine and lidocaine on myocardial conduction. (semanticscholar.org)
  • The effects of quinidine and lidocaine on the maximum upstroke velocity (Vmax) of the ventricular myocardial action potential were compared with the effects predicted by a model over a wide range of driving rates, rhythm disturbances and holding potentials. (semanticscholar.org)
  • Effects of quinidine on the sodium current of guinea pig ventricular myocytes. (semanticscholar.org)
Mefloquine9
  • tell your doctor and pharmacist if you are allergic to dextromethorphan, quinidine (Quinidex), quinine (Qualaquin), mefloquine (Lariam), any other medications, or any of the ingredients in combination dextromethorphan and quinidine capsules. (medlineplus.gov)
  • tell your doctor if you are taking mefloquine (Lariam), pimozide (Orap), quinine (Qualaquin) thioridazine, or or another product containing quinidine (Quinidex). (medlineplus.gov)
  • tell your doctor if you have or have ever had the following conditions while taking quinidine, quinine, or mefloquine: decrease in the number of blood cells in your bone marrow, lupus (a condition in which the body attacks its own tissues causing damage and swelling), or hepatitis (swelling of the liver). (medlineplus.gov)
  • If you have ever had any of these health problems when taking this drug, mefloquine, quinidine, or quinine: Bone marrow problems, hepatitis, low platelet count, or lupus. (mskcc.org)
  • If you are taking any of these drugs: Mefloquine, quinidine, or quinine. (mskcc.org)
  • You also should not take dextromethorphan and quinidine if you are also taking mefloquine, quinidine, or quinine, or if you have ever had an allergic reaction or serious medical problem caused by taking any of these medications. (wellspan.org)
  • if you are also taking mefloquine, quinidine, or quinine. (wellspan.org)
  • Do not use this medicine if you have a history of bone marrow problems, hepatitis, lupus-like syndrome, or thrombocytopenia (low platelets in the blood) caused by quinidine, quinine, or mefloquine. (limamemorial.org)
  • Concomitant quinidine, quinine, or mefloquine. (oncologynurseadvisor.com)
Nuedexta2
  • 9.Nuedexta (dextromethorphan hydrobromide and quinidine sulfate) US prescribing information. (webmd.com)
  • Nuedexta (dextromethorphan hydrobromide and quinidine sulfate), Clinical Pharmacology and Biopharmaceutics Reviews. (webmd.com)
Quinidex10
  • In patients with symptomatic atrial fibrillation/flutter whose symptoms are not adequately controlled by measures that reduce the rate of ventricular response, Quinidex (quinidine) is indicated as a means of restoring normal sinus rhythm . (rxlist.com)
  • If this use of Quinidex (quinidine) does not restore sinus rhythm within a reasonable time (see DOSAGE AND ADMINISTRATION ), then Quinidex (quinidine) should be discontinued. (rxlist.com)
  • Quinidex (quinidine) should be used only after alternative measures (e.g., use of other drugs to control ventricular rate) have been found to be inadequate. (rxlist.com)
  • Quinidex (quinidine) is also indicated for the suppression of recurrent documented ventricular arrhythmias, such as sustained ventricular tachycardia , that in the judgment of the physician are life-threatening. (rxlist.com)
  • Antiarrhythmic drugs (including Quinidex (quinidine) ) have not been shown to enhance survival in patients with ventricular arrhythmias. (rxlist.com)
  • Especially in patients with known structural heart disease or other risk factors for toxicity , initiation or dose-adjustment of treatment with Quinidex (quinidine) should generally be performed in a setting where facilities and personnel for monitoring and resuscitation are continuously available. (rxlist.com)
  • Patients with symptomatic atrial fibrillation/flutter should be treated with Quinidex (quinidine) only after ventricular rate control (e.g., with digitalis or (beta)-blockers) has failed to provide satisfactory control of symptoms. (rxlist.com)
  • Adequate trials have not identified an optimal regimen of Quinidex (quinidine) for conversion of atrial fibrillation/flutter to sinus rhythm. (rxlist.com)
  • or the patient develops significant tachycardia , symptomatic bradycardia , or hypotension , then Quinidex (quinidine) is discontinued, and other means of conversion (e.g., direct-current cardioversion ) are considered. (rxlist.com)
  • Quinidine ( Quinidex ) was one of the first clinically used antiarrhythmic agents. (brainkart.com)
Digoxin13
  • 250 mg/day result in increased serum digoxin concentrations about 2.5 times the digoxin concentration before quinidine was added. (labcorp.com)
  • The new steady-state of digoxin concentration occurs in 7 to 14 days, with signs of toxicity beginning to appear in three to seven days after initiation of quinidine therapy. (labcorp.com)
  • Therefore, serum digoxin concentrations should be measured before initiation of quinidine therapy and again in four to six days. (labcorp.com)
  • Generic pharmaceuticals are not new since even before 1965 several products appeared on the market such as phenobarbitol, digoxin, quinidine , and many others and nobody paid much attention to them. (wordnik.com)
  • To the editor: Mungall and associates (1) presented data which quantitate both the time course of the digoxin-quinidine interaction, and the magnitude of change in digoxin renal clearance induced by quinidine. (annals.org)
  • We (2) and others (3) agree with the conclusions by Mungall and associates that digoxin levels achieve near steady state 6 days after starting quinidine therapy and that digoxin renal clearance is reduced by quinidine. (annals.org)
  • If patient has atrial fibrillation, expect to give digoxin, calcium channel blocker, beta-adrenergic blocker, and possibly an anticoagulant before administering quinidine. (thefreedictionary.com)
  • The interactions between digoxin and quinine and quinidine that affect the renal and biliary clearances of digoxin were investigated in eight healthy subjects. (nih.gov)
  • In four of the subjects, the study was repeated by administration of equimolar doses of the diastereoisomer quinidine together with digoxin, enabling a within-subject comparison of the effects of the two isomers on digoxin clearance. (nih.gov)
  • These findings explain the difference in magnitude between quinidine and quinine in regard to the interaction with digoxin and imply a different degree of stereoselectivity for these isomers in the renal and biliary secretory systems of digoxin. (nih.gov)
  • Digoxin levels may be increased by quinidine. (vetstream.com)
  • It is recommended that the dose of digoxin be decreased by 1/2 when adding quinidine and that serum drug levels of both quinidine and digoxin be assessed. (vetstream.com)
  • Control the ventricular rate and CHF (if present) with digoxin or calcium channel blockers before the administration of quinidine. (medscape.com)
Arrhythmias8
  • Quinidine may increase the chance of having arrhythmias (irregular heartbeats) and has not been proven to help people without life-threatening arrhythmias to live longer. (medlineplus.gov)
  • Quinidine is occasionally used as a class I antiarrhythmic agent to prevent ventricular arrhythmias, particularly in Brugada Syndrome, although its safety in this indication is uncertain. (wikipedia.org)
  • Quinidine usually is used only to treat life-threatening arrhythmias. (empowher.com)
  • if these arrhythmias develop, they should be treated as one would treat a quinidine overdose. (wordnik.com)
  • Quinidine has proarrhythmic properties and may induce or worsen cardiac arrhythmias. (pdr.net)
  • Quinidine has been associated with increased mortality when used to treat various arrhythmias. (pdr.net)
  • Genetically determined steady-state interaction between encainide and quinidine in patients with arrhythmias. (aspetjournals.org)
  • Quinidine serum concentrations above the therapeutic range can cause increased QT interval or QRS complex widening (>35%-50%) on the electrocardiogram, cinchonism, hypotension, high-degree atrioventricular block, and ventricular arrhythmias. (mhmedical.com)
Malaria9
  • Quinidine is also sometimes used to treat malaria. (medlineplus.gov)
  • Although intravenous quinidine is sometimes used to treat Plasmodium falciparum malaria, the future availability of this agent is uncertain. (wikipedia.org)
  • Intravenous quinidine is indicated whenever oral therapy is not possible, in high-density infections (greater than 5% of red blood cells infected), and in the presence of complications such as cerebral malaria or acute renal failure. (cdc.gov)
  • Quinine, a famous malaria treatment, and quinidine , an antiarrhythmic medication, are made from the bark of the cinchona tree. (wordnik.com)
  • Diastereoisomers of quinidine and quinine are used to treat arrhythmia and malaria, respectively. (mdpi.com)
  • Quinidine is used to treat abnormal heart rhythms and malaria. (rxwiki.com)
  • Quinine and quinidine: a comparison of EKG effects during the treatment of malaria. (tropmedres.ac)
  • We recorded electrocardiograms from 31 patients receiving quinine and 14 patients receiving quinidine for the treatment of Plasmodium falciparum malaria. (tropmedres.ac)
  • Intravenous quinidine is also indicated for treatment of P. falciparum malaria. (chemeurope.com)
Concentrations17
  • At micromolar concentrations, quinidine inhibits Na+/K+-ATPase by binding to the same receptor sites as the digitalis glycosides such as ouabain. (wikipedia.org)
  • Concomitant administration of phenytoin increases hepatic metabolism, and therefore decreases half-life and serum quinidine concentrations. (labcorp.com)
  • Through a MEDLINE search of all English medical literature (1966 to 1994) documenting possible interactions between quinidine and erythromycin, retrospective patient chart review, and analysis of the relationship between serum quinidine concentrations and significant clinical events, deduce the possibility of a quinidine and erythromycin pharmacokinetic and pharmacodynamic interaction in this particular patient case. (biomedsearch.com)
  • RESULTS: This case demonstrated a probable erythromycin-quinidine pharmacokinetic interaction that led to a decrease in quinidine apparent clearance, an increase in quinidine serum concentrations, and a possible quinidine toxicity. (biomedsearch.com)
  • CONCLUSION: Serum quinidine concentrations, electrocardiograms, and other factors that may predispose patients to torsades de pointes, such as hypokalemia and hypomagnesemia, should be monitored closely if quinidine is coadministered with erythromycin. (biomedsearch.com)
  • The activity of this low affinity component was unaffected by quinidine in the concentrations studied. (nih.gov)
  • May be increased to 600 mg PO every 6 hours if needed, based on serum quinidine concentrations. (pdr.net)
  • Moreover, the formation of 3-hydroxyquinidine (detected only in perfusate as unconjugated 3-hydroxyquinidine) remained relatively linear while the formation of O-desmethylquinidine (present in bile and perfusate mostly as conjugates) apparently approached saturation kinetics within the quinidine concentrations used. (aspetjournals.org)
  • The dose-dependent character of quinidine elimination cannot be attributed to changes in drug binding, as the blood/plasma ratio (4.07) and the degree of drug unbound in plasma (66.5%) remained unaltered for the quinidine concentrations used. (aspetjournals.org)
  • Quinidine serum concentrations after an intravenous dose (circles with solid line) and three different oral tablets (doses normalized to provide 200 mg of quinidine base systemically). (mhmedical.com)
  • After an intravenous dose, quinidine serum concentrations decline according to a two-compartment model, which demonstrates a distribution phase that lasts for 20-30 minutes postinjection. (mhmedical.com)
  • Cinchonism is a collection of symptoms that includes tinnitus, blurred vision, lightheadedness, tremor, giddiness, and altered hearing which decreases in severity with lower quinidine concentrations. (mhmedical.com)
  • The anticholinergic actions of quinidine predominate at lower plasma concentrations. (brainkart.com)
  • Higher concentrations of quinidine have a direct effect of depressing the rate of spontaneous diastolic depolarization. (brainkart.com)
  • Serum K + concentrations have a major influence on the activity of quinidine on cardiac tissue. (brainkart.com)
  • Low extracel-lular K + concentrations antagonize the depressant ef-fects of quinidine on membrane responsiveness, whereas high extracellular K + concentrations increase quinidine's ability to depress membrane responsive-ness. (brainkart.com)
  • At normal therapeutic plasma concentrations, quinidine prolongs the PR, the QRS, and the QT intervals. (brainkart.com)
Dosage3
  • When oral quinidine is given as a rapidly absorbed dosage form such as quinidine sulfate tablets, a similar distribution phase is also observed with a duration of 20-30 minutes. (mhmedical.com)
  • No data regarding the Paedriatic dosage details of Quinidine is available. (druginfosys.com)
  • No data regarding the neonatal dosage details of Quinidine is available. (druginfosys.com)
Combination of dextromethorphan2
  • The combination of dextromethorphan and quinidine comes as a capsule to take by mouth. (medlineplus.gov)
  • Take the combination of dextromethorphan and quinidine exactly as directed. (medlineplus.gov)
Toxicity3
  • Quinidine intoxication can lead to a collection of symptoms collectively known as cinchonism, with tinnitus (ringing in the ears) being among the most characteristic and common symptoms of this toxicity syndrome. (wikipedia.org)
  • Cinchonism is usually a sign of chronic quinidine toxicity, but it may appear in sensitive patients after a single moderate dose of several hundred milligrams. (drugs.com)
  • These reagents are used to measure quinidine levels in patients, e.g., to determine the adequacy of therapy, and in the diagnosis of a drug overdose or drug-related toxicity. (medicalproductguide.com)
Kwin1
Inhibits5
  • Quinidine also inhibits the transport protein P-glycoprotein and so can cause some peripherally acting drugs such as loperamide to have central nervous system side effects, such as respiratory depression, if the two drugs are coadministered. (wikipedia.org)
  • quinidine is a drug that inhibits the metabolism of dextromethorphan which results in a sustained elevation of dextromethorphan in the brain. (mssociety.ca)
  • Inhibits the metabolism of quinidine by inhibiting hepatic microsomal enzymes, thereby increasing its effect. (vetstream.com)
  • Quinidine, a class Ia antiarrhythmic agent that inhibits outward transient K current (I to1 ), has been proposed as an adjuvant treatment in BrS patients (2-4) , but there are limited data about its long-term effectiveness. (onlinejacc.org)
  • Quinidine inhibits transmembrane sodium influx into the conduction system of the heart, thereby decreasing conduction velocity. (mhmedical.com)
Dose of quinidine2
  • The company reformulated the drug with a lower dose of quinidine and conducted new studies, she said. (thefreedictionary.com)
  • Your doctor may adjust your dose of quinidine if you are a poor metabolizer. (rxwiki.com)
Davis's Drug Guide1
  • dextromethorphan/quinidine is a topic covered in the Davis's Drug Guide . (unboundmedicine.com)
Effect of quinidine4
  • The effect of quinidine on the ion channels is to prolong the cardiac action potential, thereby prolonging the QT interval on the surface ECG. (wikipedia.org)
  • As measured by antiarrhythmic effects in animals, by QTc prolongation in human volunteers, or by various in vitro techniques, 3HQ has at least half the antiarrhythmic activity of the parent compound, so it may be responsible for a substantial fraction of the effect of quinidine sulfate in chronic use. (nih.gov)
  • The indirect effect of quinidine on the sinoatrial node is a result of the drug's potential to exert an anti-cholinergic action resulting in a slight increase in heart rate. (brainkart.com)
  • The effect of quinidine on digitoxin single-dose pharmacokinetics was evaluated in five healthy adults. (elsevier.com)
Quinine and quinidine1
  • The present invention provides methods for purifying, identifying and using optically active isomers of quinine and quinidine as well as compositions comprising such optically active isomers. (freepatentsonline.com)
Dextromethorphan hydrobromide and quinidine sulfate1
  • This medication contains a combination of two medications: dextromethorphan hydrobromide and quinidine sulfate. (rxwiki.com)
Tablets7
  • Quinidine sulfate tablets are usually is taken every 6 hours. (medlineplus.gov)
  • The absolute bioavailability of quinidine from quinidine sulfate tablets is about 70%, but this varies widely (45 to 100%) between patients. (nih.gov)
  • Crush the tablets to a fine powder or use the quinidine sulfate powder. (uspharmacist.com)
  • Do not crush or chew quinidine tablets. (rxwiki.com)
  • Immediate-release quinidine tablets (diamonds with dashed line) are rapidly absorbed and also show a distinct distribution phase. (mhmedical.com)
  • Quinidine Sulfate Controlled-Release Tablets is associated with an increased risk of death when used to treat non-life-threatening irregular heartbeat. (drugspedia.net)
  • Ask your health care provider if Quinidine Sulfate Controlled-Release Tablets may interact with other medicines that you take. (drugspedia.net)
Alkaloid4
  • Their great value depends upon the presence of certain alkaloid substances called quinine, cinchonine, and quinidine , which exist in the bark in combination with tannic and other acids. (wordnik.com)
  • Quinidine is an alkaloid extracted from the bark of the Cinchona tree with class 1A antiarrhythmic and antimalarial effects. (fishersci.com)
  • Quinidine is an alkaloid extracted from the bark of the genus Cinchona ledgeriana (Moens). (hardware-wholesale.com)
  • Quinidine is an alkaloid obtained from various species of Cinchona or its hybrids, from Remijia pedunculata, or from quinine. (brainkart.com)
Oral quinidine2
  • The elimination half-life of oral quinidine is 6 to 8 hours, and it is eliminated by the cytochrome P450 system in the liver. (wikipedia.org)
  • the protocol was conducted once while each subject was taking oral quinidine, for 3 weeks, and then repeated 10 days after discontinuing quinidine treatment. (elsevier.com)
Therapeutic4
  • If this regimen is well tolerated, if the serum quinidine level is still well within the laboratory's therapeutic range , and if this regimen has not resulted in conversion, then the dose may be cautiously raised. (rxlist.com)
  • What we have done is recognized that you can inhibit ones ability to metabolize dextromethorphan by adding quinidine , which is a therapeutic. (wordnik.com)
  • Quinidine has a narrow therapeutic index (serum concentration range: 2-6 mcg/ml). (pdr.net)
  • The generally accepted therapeutic range for quinidine is 2-6 μg/mL. (mhmedical.com)
Doses3
  • The most important of quinidine's metabolites is 3-hydroxyquinidine (3HQ), serum levels of which can exceed those of quinidine in patients receiving conventional doses of quinidine sulfate. (nih.gov)
  • A genetically determined pharmacokinetic and pharmacodynamic interaction between quinidine and single doses of encainide in healthy volunteers has previously been described. (aspetjournals.org)
  • However, quinidine may remain in the bodies of older adults longer than it does in younger adults, which may increase the risk of side effects and which may require lower doses. (allinahealth.org)
Side effects of dextromethorphan2
  • Some side effects of dextromethorphan / quinidine may occur that usually do not need medical attention. (drugs.com)
  • Common side effects of dextromethorphan/quinidine may include diarrhea and vomiting. (rxwiki.com)
Interact with dextromethorphan and quinidine3
  • Many other medications may also interact with dextromethorphan and quinidine, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list. (medlineplus.gov)
  • Some medicines can interact with dextromethorphan and quinidine and should not be used at the same time. (wellspan.org)
  • These medicines may interact with dextromethorphan and quinidine and cause a serious condition called serotonin syndrome. (uncmedicalcenter.org)
Thrombocytopenia2
  • Quinidine can cause thrombocytopenia, granulomatous hepatitis, myasthenia gravis, and torsades de pointes (dangerous heart rhythm), so is not used much today. (wikipedia.org)
  • Quinidine-induced thrombocytopenia (low platelet count) is mediated by the immune system, and may lead to thrombocytic purpura. (wikipedia.org)
Pharmacokinetics1
  • Inhibition of UGT2B7 by quinidine was also investigated further, because the effects of this compound on morphine pharmacokinetics (a known UGT2B7 substrate) have been ascribed to inhibition of P-glycoprotein. (aspetjournals.org)
Torsades de poin2
  • Serious cardiovascular events, including QT prolongation, torsades de pointes, ventricular tachycardia, cardiac arrest, and/or sudden death have occurred in patients using cisapride, pimozide, levacetylmethadol (levomethadyl), methadone or quinidine concomitantly with itraconazole and/or other CYP3A4 inhibitors. (thefreedictionary.com)
  • QT prolongation and development of torsades de pointes with the concomitant administration of oral erythromycin base and quinidine. (webmd.com)
Isomer of quinine3
  • Quinidine is an isomer of quinine. (sigmaaldrich.com)
  • Quinidine is the dextrorotatory isomer of quinine. (brainkart.com)
  • Immunoassay reagents intended to perform quantitative analyses on a body fluid sample (e.g., serum, plasma) to measure the level of quinidine, an optical isomer of quinine, present in the sample. (medicalproductguide.com)
10mg1
  • Dextromethorphan/quinidine (DM/Q) 20mg/10mg one capsule once daily for 1 week, followed by DM/Q 20mg /10 mg twice daily for subsequent 4 weeks, and finally DM/Q 20mg/10mg once daily for 7days. (clinicaltrials.gov)
Antiarrhythmic drugs3
  • Taking antiarrhythmic drugs, including quinidine, may increase the risk of death. (medlineplus.gov)
  • 47357] Guidelines recommend quinidine 324 to 648 mg PO every 8 hours as an option for the maintenance of sinus rhythm in patients with atrial fibrillation only when other antiarrhythmic drugs cannot be used. (pdr.net)
  • A unifying molecular model for the interaction of antiarrhythmic drugs with cardiac sodium channels: application to quinidine and lidocaine. (semanticscholar.org)
Serum quinidine concentration2
  • Adjust dosages to produce a serum quinidine concentration of 2 to 6 mcg/mL. (pdr.net)
  • When given intravenously, the serum quinidine concentration-time curve follows a two-compartment model. (mhmedical.com)
Antibodies recognize quinidine1
  • Specificity: These antibodies recognize quinidine. (qedbio.com)
Combined with dextromethorphan1
  • When combined with dextromethorphan, quinidine works by increasing the amount of dextromethorphan in the body. (medlineplus.gov)
Concentration and quinidine1
  • Experimental data is presented and discussed on the effects of temperature, K and Na concentration, and quinidine on transmembrane ion fluxes and the incidence of fibrillation in isolated rabbit atria. (ahajournals.org)
Drugs9
  • tell your doctor and pharmacist if you are allergic to quinidine, quinine, or any other drugs. (medlineplus.gov)
  • Caffeine interferes with drugs that regulate heart rhythm, such as quinidine and propranolol (Inderal). (yourdictionary.com)
  • Results show that both drugs block the hERG channel, with quinine 14-fold less potent than quinidine. (mdpi.com)
  • The mutation decreases affinity of the two drugs with hERG, and quinine was more potent than quinidine in F656C-hERG blockage. (mdpi.com)
  • Quinidine belongs to a group of drugs called antiarrhythmics. (rxwiki.com)
  • CYP2D6 is a protein in your body that is involved in the elimination of quinidine and other drugs from your body. (rxwiki.com)
  • The half-life of quinidine may be reduced by as much as 50% as a consequence of hepatic enzyme induction by these drugs. (vetstream.com)
  • If you are taking monoamine oxidase inhibitors (MAOIs), quinidine, or quinidine-related drugs. (nuedexta.com)
  • If you have previously had an allergic reaction to dextromethorphan, quinidine or quinidine-like drugs. (nuedexta.com)
Atrial fibrillation2
  • 1 After ventricular rate has been controlled, quinidine therapy can be used to chemically convert atrial fibrillation to normal sinus rhythm for a patient. (mhmedical.com)
  • Quinidine maintains normal heart rhythm following cardioversion of atrial fibrillation or flutter. (medscape.com)
Automaticity3
  • Because it slows conduction and prolongs the refractory period of the accessory pathway and suppresses automaticity of ectopic pacemakers, quinidine may prevent recurrences of paroxysmal supraventricular tachycardia caused by reentry over a concealed pathway or AV reciprocating tachycardia associated with the Wolff-Parkinson-White syndrome. (labcorp.com)
  • Automaticity is decreased during quinidine therapy. (mhmedical.com)
  • Quinidine can depress the automaticity of ventricu-lar pacemakers by depressing the slope of phase 4 de-polarization. (brainkart.com)
Antiarrhythmics2
  • Quinidine is in a class of medications called antiarrhythmics. (medlineplus.gov)
  • Quinidine is in a class of medications called antiarrhythmics (abnormal heart rhythm). (rxwiki.com)
Form of quinidine2
  • The permanently charged quinidinium compound produced nearly identical effects as quinidine when present only on cytoplasmic side of the channel, suggesting the positive-charged form of quinidine is responsible for the effects on the channel. (aspetjournals.org)
  • These data indicate that 1) the charged form of quinidine blocks the HK2 channel after it opens, 2) binding occurs within the transmembrane electrical field (probably in or near the ion permeation pathway), and 3) unbinding is required before the channel can close. (aspetjournals.org)
Increase in quinidine1
  • The disposition of quinidine and the kinetics of metabolite formation were studied in the once-through perfused rat liver preparation by the stepwise increase in quinidine concentration. (aspetjournals.org)
Metabolism of quinidine1
  • Possible inhibition of hepatic metabolism of quinidine by erythromycin. (webmd.com)
Interaction of quinidine2
  • The interaction of quinidine and other local anesthetic/antiarrhythmic agents with voltage-gated ion channels has been proposed to be the result of binding of these compounds within the inner vestibule of the channel pore ( Hille, 1977 ). (aspetjournals.org)
  • The interaction of quinidine with a cloned human cardiac potassium channel (HK2) expressed in a stable mouse L cell line was studied using the whole-cell tight-seal voltage-clamp technique. (aspetjournals.org)
Elimination of quinidine1
  • Rapid elimination of quinidine in pediatric patients. (ucdenver.edu)
Pseudobulbar2
  • Dextromethorphan/quinidine is a prescription medication approved for the treatment of pseudobulbar affect (PBA), a condition characterized by involuntary, sudden, uncontrolled episodes of laughing or crying, when there appears to be nothing to laugh or cry about. (rxwiki.com)
  • Dextromethorphan/quinidine is a prescription medication is used to treat pseudobulbar affect (PBA) a condition of sudden, frequent outbursts of crying and laughing that can not be controlled. (rxwiki.com)
Antigen1
  • Antigen: Quinidine conjugated to KLH. (qedbio.com)
Inhibition3
  • It is concluded that the effect of this drug interaction in patients is determined by differential sensitivities to inhibition by quinidine of encainide O-demethylation and subsequent ODE 3-methoxylation. (aspetjournals.org)
  • Mechanism of inhibition of mouse Slo3 (KCa 5.1) potassium channels by quinine, quinidine and barium. (guidetopharmacology.org)
  • Quinidine can relax vascular smooth muscle directly as well as indirectly by inhibition of α 1 -adrenoceptors. (brainkart.com)
Sodium9
  • Quinidine acts as a blocker of voltage-gated sodium channels. (wikipedia.org)
  • Like all other class I antiarrhythmic agents, quinidine primarily works by blocking the fast inward sodium current (INa). (wikipedia.org)
  • Quinidine stabilizes the neuronal membrane by binding to and inhibiting voltage-gated sodium channels, thereby inhibiting the sodium influx required for the initiation and conduction of impulses resulting in an increase of the threshold for excitation and decreased depolarization during phase 0 of the action potential. (fishersci.com)
  • In subjects with the extensive metabolizer phenotype, quinidine blunted encainide-induced QRS prolongation (a marker of sodium channel block) because it impaired encainide biotransformation to the potent active metabolites O-desmethyl encainide (ODE) and 3-methoxy-O-desmethyl encainide. (aspetjournals.org)
  • Therefore, the purpose of this study was to test the hypothesis that quinidine would inhibit sodium channel block (and by inference arrhythmia suppression) during encainide therapy in patients with the extensive metabolizer phenotype. (aspetjournals.org)
  • Like all other class I antiarrhythmic agents, quinidine primarily works by blocking the fast inward sodium current (INa) which causes the phase 0 depolarization of the cardiac action potential to decrease (decreased Vmax). (qedbio.com)
  • Quinidine is the right-handed body of quinine, which has similar pharmacological properties, but quinidine is 5 to 10 times stronger than quinine in the heart, and it binds to the lipoprotein of the sodium channel on the myocardial cell membrane, making the channel The gate narrows to prevent Na+ inflow, resulting in a decrease in the depolarization speed of the 0 phase and a slower conduction. (hardware-wholesale.com)
  • Several recent studies have reported potassium sodium-activated channel subfamily T member 1 ( KCNT1 ) mutations in epilepsy patients on quinidine therapy. (jle.com)
  • Quinidine dampens the excitability of cardiac and skeletal muscles by blocking sodium and potassium currents across cellular membranes. (medicalproductguide.com)
Grapefruit juice1
  • Avoid drinking grapefruit juice while taking quinidine. (empowher.com)
Conduction3
  • These findings suggest that the quinidine-induced subconductance activity may be the result of a partial occlusion of the channel pore interfering with ion conduction. (aspetjournals.org)
  • The net effect of these cellular changes is that quinidine causes increased refractoriness and decreased conduction in heart conduction tissue which establishes a bidirectional block in reentrant pathways. (mhmedical.com)
  • Both the direct and indirect actions of quinidine are important in determining its ultimate effect on A-V conduction. (brainkart.com)
CYP2D61
  • Goldstein and his colleagues tested the supplement against quinidine , a known CYP2D6 inhibitor. (thefreedictionary.com)
Antimalarial1
  • Quinidine exerts its antimalarial activity by acting primarily as an intra-erythrocytic schizonticide through association with the heme polymer (hemazoin) in the acidic food vacuole of the parasite thereby preventing further polymerization by heme polymerase enzyme. (fishersci.com)
Take quinidine6
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