Quinidine
An optical isomer of quinine, extracted from the bark of the CHINCHONA tree and similar plant species. This alkaloid dampens the excitability of cardiac and skeletal muscles by blocking sodium and potassium currents across cellular membranes. It prolongs cellular ACTION POTENTIALS, and decreases automaticity. Quinidine also blocks muscarinic and alpha-adrenergic neurotransmission.
Quinine
An alkaloid derived from the bark of the cinchona tree. It is used as an antimalarial drug, and is the active ingredient in extracts of the cinchona that have been used for that purpose since before 1633. Quinine is also a mild antipyretic and analgesic and has been used in common cold preparations for that purpose. It was used commonly and as a bitter and flavoring agent, and is still useful for the treatment of babesiosis. Quinine is also useful in some muscular disorders, especially nocturnal leg cramps and myotonia congenita, because of its direct effects on muscle membrane and sodium channels. The mechanisms of its antimalarial effects are not well understood.
Anti-Arrhythmia Agents
Agents used for the treatment or prevention of cardiac arrhythmias. They may affect the polarization-repolarization phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibers. Anti-arrhythmia agents are often classed into four main groups according to their mechanism of action: sodium channel blockade, beta-adrenergic blockade, repolarization prolongation, or calcium channel blockade.
Cytochrome P-450 CYP2D6
Disopyramide
Flecainide
Dextromethorphan
Methyl analog of DEXTRORPHAN that shows high affinity binding to several regions of the brain, including the medullary cough center. This compound is an NMDA receptor antagonist (RECEPTORS, N-METHYL-D-ASPARTATE) and acts as a non-competitive channel blocker. It is one of the widely used ANTITUSSIVES, and is also used to study the involvement of glutamate receptors in neurotoxicity.
Oxidoreductases, O-Demethylating
Propafenone
Sparteine
Debrisoquin
An adrenergic neuron-blocking drug similar in effects to GUANETHIDINE. It is also noteworthy in being a substrate for a polymorphic cytochrome P-450 enzyme. Persons with certain isoforms of this enzyme are unable to properly metabolize this and many other clinically important drugs. They are commonly referred to as having a debrisoquin 4-hydroxylase polymorphism.
Transport of fluid by lens epithelium. (1/618)
We report for the first time that cultured lens epithelial cell layers and rabbit lenses in vitro transport fluid. Layers of the alphaTN4 mouse cell line and bovine cell cultures were grown to confluence on permeable membrane inserts. Fluid movement across cultured layers and excised rabbit lenses was determined by volume clamp (37 degrees C). Cultured layers transported fluid from their basal to their apical sides against a pressure head of 3 cmH2O. Rates were (in microliter. h-1. cm-2) 3.3 +/- 0.3 for alphaTN4 cells (n = 27) and 4.7 +/- 1.0 for bovine layers (n = 6). Quinidine, a blocker of K+ channels, and p-chloromercuribenzenesulfonate and HgCl2, inhibitors of aquaporins, inhibited fluid transport. Rabbit lenses transported fluid from their anterior to their posterior sides against a 2.5-cmH2O pressure head at 10.3 +/- 0.62 microliter. h-1. lens-1 (n = 5) and along the same pressure head at 12.5 +/- 1.1 microliter. h-1. lens-1 (n = 6). We calculate that this flow could wash the lens extracellular space by convection about once every 2 h and therefore might contribute to lens homeostasis and transparency. (+info)Effects of dauricine, quinidine, and sotalol on action potential duration of papillary muscles in vitro. (2/618)
AIM: To compare the characteristics of dauricine, sotalol, and quinidine on action potential duration (APD). METHODS: Using intracellular microelectrode method to record APD in guinea pig papillary muscles. RESULTS: Dauricine 20 mumol.L-1 prolonged action potential at 90% repolarization, the percent of APD prolongation were 22 +/- 8, 11 +/- 6, 9 +/- 5, 7 +/- 5, 6 +/- 3, 4.3 +/- 2.8, 4.5 +/- 2.8 at the cycle lengths of 200-2000 ms, dauricine became more effective in lengthening APD at short cycle lengths. The effect of dauricine on prolonging APD exhibited normal use-dependence, whereas quinidine 1 mumol.L-1 and sotalol 10 mumol.L-1 were less effective in lengthening APD at short cycle lengths. The effect of quinidine and sotalol on APD exhibited reverse use-dependence. CONCLUSSION: The effect of dauricine on APD depends on activation frequency. (+info)In vitro metabolism of quinidine: the (3S)-3-hydroxylation of quinidine is a specific marker reaction for cytochrome P-4503A4 activity in human liver microsomes. (3/618)
The aim of this study was to evaluate the (3S)-3-hydroxylation and the N-oxidation of quinidine as biomarkers for cytochrome P-450 (CYP)3A4 activity in human liver microsome preparations. An HPLC method was developed to assay the metabolites (3S)-3-hydroxyquinidine (3-OH-Q) and quinidine N-oxide (Q-N-OX) formed during incubation with microsomes from human liver and from Saccharomyces cerevisiae strains expressing 10 human CYPs. 3-OH-Q formation complied with Michaelis-Menten kinetics (mean values of Vmax and Km: 74.4 nmol/mg/h and 74.2 microM, respectively). Q-N-OX formation followed two-site kinetics with mean values of Vmax, Km and Vmax/Km for the low affinity isozyme of 15.9 nmol/mg/h, 76.1 microM and 0.03 ml/mg/h, respectively. 3-OH-Q and Q-N-OX formations were potently inhibited by ketoconazole, itraconazole, and triacetyloleandomycin. Isozyme specific inhibitors of CYP1A2, -2C9, -2C19, -2D6, and -2E1 did not inhibit 3-OH-Q or Q-N-OX formation, with Ki values comparable with previously reported values. Statistically significant correlations were observed between CYP3A4 content and formations of 3-OH-Q and Q-N-OX in 12 human liver microsome preparations. Studies with yeast-expressed isozymes revealed that only CYP3A4 actively catalyzed the (3S)-3-hydroxylation. CYP3A4 was the most active enzyme in Q-N-OX formation, but CYP2C9 and 2E1 also catalyzed minor proportions of the N-oxidation. In conclusion, our studies demonstrate that only CYP3A4 is actively involved in the formation of 3-OH-Q. Hence, the (3S)-3-hydroxylation of quinidine is a specific probe for CYP3A4 activity in human liver microsome preparations, whereas the N-oxidation of quinidine is a somewhat less specific marker reaction for CYP3A4 activity, because the presence of a low affinity enzyme is demonstrated by different approaches. (+info)Pseudo second degree atrioventricular block with bradycardia. Successful treatment with quinidine. (4/618)
Pseudo second degree atrioventricular block resulting from blocked His premature beats was successfully treated with quinidine. The diagnosis was proved by His bundle electrogam which showed both blocked and conducted His premature beats. The blocked His prematures produced second degree atrioventricular block by making the atrioventricular junction refractory. Quinidine abolished both conducted and blocked His extrasystoles. There has been no recurrence of arrhythmia during a one-year follow-up. (+info)Novel membrane transporter OCTN1 mediates multispecific, bidirectional, and pH-dependent transport of organic cations. (5/618)
In the present study, functional characteristics of organic cation transporter (OCTN)1, which was cloned as the pH-dependent tetraethylammonium (TEA) transporter when expressed in mammalian human embryonic kidney (HEK)293 cells, were further investigated using Xenopus oocytes as well as HEK293 cells as gene expression systems. When OCTN1-derived complementary RNA was injected into Xenopus oocytes, pH-dependent transport of [14C]TEA was observed as the same in HEK293 cells. In contrast, a replacement of sodium ions with potassium ions in the surrounding medium did not cause any change in [14C]TEA uptake in Xenopus oocytes expressed with OCTN1. In addition, when OCTN1 was expressed in HEK293 cells, efflux of TEA from the cells was pH dependent, with an accelerated rate at acidic external medium pH. Accordingly, membrane potential or sodium ions are suggested to have no influence on [14C]TEA transport and the transport activity of OCTN1 is directly affected by pH itself. Furthermore, addition of the unlabeled TEA in external medium enhanced the efflux of preloaded [14C]TEA. These observations suggest that OCTN1 is a pH-dependent and bidirectional TEA transporter. OCTN1-mediated [14C]TEA uptake was inhibited by various organic cations such as cimetidine, procainamide, pyrilamine, quinidine, quinine, and verapamil. In addition, uptakes of cationic compounds such as [3H]pyrilamine, [3H]quinidine, and [3H]verapamil and zwitterionic L-[3H]carnitine were increased by expression of OCTN1 in Xenopus oocytes. Accordingly, OCTN1 was functionally demonstrated to be a multispecific and pH-dependent organic cation transporter, which presumably functions as a proton/organic cation antiporter at the renal apical membrane and other tissues. (+info)Effects of a novel cardioprotective drug, JTV-519, on membrane currents of guinea pig ventricular myocytes. (6/618)
We investigated effects of a novel cardioprotective drug, JTV-519 (4-[3-(4-benzylpiperidin-1-yl)propionyl]-7-methoxy-2,3,4,5-tetrahy dro-1,4-benzothiazepine monohydrochloride) on membrane currents of guinea pig ventricular myocytes by whole-cell voltage and current clamp methods. The fast Na+ current (iNa) was activated by ramp pulses from various holding potentials of -90, -80 or -60 mV to 10 mV with various intervals. At 0.2 Hz, JTV-519 inhibited iNa in a concentration-dependent manner with an IC50 of approximately 1.2 and 2 microM at the holding potential of -60 and -90 mM, respectively, implicating a voltage-dependent block. Increasing the pulse frequency from 1 to 2 or 3.3 Hz in the presence of 1 microM JTV-519 shortened the time-course and increased the level of iNa block, indicating a frequency-dependent block. The time-course of iNa blocking by JTV-519 was slower than that of lidocaine and similar to that of quinidine. Ca2+ current (iCa) and the inwardly rectifying K+ current (iK1) were also inhibited by JTV-519. JTV-519 decreased the duration and the height of the plateau of the action potential. We conclude that JTV-519 has frequency- and voltage-dependent blocking effects on iNa as well as inhibition of iCa and iK1. (+info)Alkalinization-induced K+ current of the mouse megakaryocyte. (7/618)
We have recently found that mouse megakaryocytes responded to extracellular alkalinization to pH > 8.0, generating a K+ current under voltage-clamped conditions with the whole cell recording mode of the patch-clamp technique. The purpose of this study was to physiologically and pharmacologically characterize the alkaline-dependent K+ conductance of the megakaryocyte membrane. The alkalinization-induced K+ current (I(ALK)) did not seem to be Ca2+-dependent since I(ALK) was allowed to be generated under intracellularly Ca2+-buffered conditions with 10 mM EGTA, which completely prevented the generation of caffeine-induced Ca2+-activated currents of mouse megakaryocytes; and no [Ca2+]i elevation was evoked by the alkalinization protocol in contrast to a significant increase in [Ca2+]i in response to caffeine when [Ca2+]i was measured with a fura 2 ratiometry. I(ALK) was strongly suppressed with tetraethylammonium (TEA), 4-aminopyridine (4-AP) and streptomycin (SM), but was completely resistant to quinidine (QND). The values of IC50 for the suppression of I(ALK) with TEA, 4-AP and SM were 5.6, 0.47 and 1.5 mM, respectively. Voltage-gated K+ currents (I(K)) of the same megakaryocyte preparation were weakly suppressed with TEA and 4-AP, while they were significantly suppressed with either SM or QND. These results suggest that mouse megakaryocytes possess K+ conductance that was activated by extracellular alkalinization and that probably differs from conventional K+ conductance in its pharmacological properties. (+info)Enhancing effects of salicylate on tonic and phasic block of Na+ channels by class 1 antiarrhythmic agents in the ventricular myocytes and the guinea pig papillary muscle. (8/618)
OBJECTIVE: To study the interaction between salicylate and class 1 antiarrhythmic agents. METHODS: The effects of salicylate on class 1 antiarrhythmic agent-induced tonic and phasic block of the Na+ current (INa) of ventricular myocytes and the upstroke velocity of the action potential (Vmax) of papillary muscles were examined by both the patch clamp technique and conventional microelectrode techniques. RESULTS: Salicylate enhanced quinidine-induced tonic and phasic block of INa at a holding potential of -100 mV but not at a holding potential of -140 mV; this enhancement was accompanied by a shift of the hinfinity curve in the presence of quinidine in a further hyperpolarized direction, although salicylate alone did not affect INa. Salicylate enhanced the tonic and phasic block of Vmax induced by quinidine, aprindine and disopyramide but had little effect on that induced by procainamide or mexiletine; the enhancing effects were related to the liposolubility of the drugs. CONCLUSIONS: Salicylate enhanced tonic and phasic block of Na+ channels induced by class 1 highly liposoluble antiarrhythmic agents. Based on the modulated receptor hypothesis, it is probable that this enhancement was mediated by an increase in the affinity of Na+ channel blockers with high lipid solubility to the inactivated state channels. (+info)
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Quinidine
... sulfate is used in the treatment of atrial fibrillation in horses. Grace AA, Camm AJ (1998). "Quinidine". N. Engl. J ... Quinidine is also used to treat short QT syndrome. Eli Lilly has discontinued manufacture of parenteral quinidine gluconate in ... The dose of quinidine (10mg two times daily) is about 1/40th of a relatively low antiarrhythmic dose (400mg, twice or 3 times ... Quinidine is also an inhibitor of the cytochrome P450 enzyme 2D6, and can lead to increased blood levels of lidocaine, beta ...
Pseudobulbar affect
... dextromethorphan hydrobromide 30 mg/quinidine sulfate 10 mg (N=110) Nuedexta - dextromethorphan hydrobromide 20 mg/quinidine ... Quinidine sulfate affects the way the heart beats, and is generally used in people with certain heart rhythm disorders. It is ... Dextromethorphan/quinidine is a combination of these two generic drugs, and is the first FDA-approved drug for the treatment of ... "Quinidine sulfate". PDRhealth™. 2016. Archived from the original on 2015-09-05. Retrieved 2016-02-18. "Label: NUEDEXTA- ...
Brugada syndrome
Quinidine is an antiarrhythmic drug that may reduce the chance of serious abnormal heart rhythms occurring in some people with ... Yang F, Hanon S, Lam P, Schweitzer P (April 2009). "Quinidine revisited". The American Journal of Medicine. 122 (4): 317-21. ... Belhassen B, Glick A, Viskin S (September 2004). "Efficacy of quinidine in high-risk patients with Brugada syndrome". ... while quinidine may be used longer term. Testing people's family members may be recommended. The condition affects between 1 ...
Quinine
... (and quinidine) are used as the chiral moiety for the ligands used in Sharpless asymmetric dihydroxylation as well as ... No injectable preparation of quinine is licensed in the US; quinidine is used instead. Quinine is a flavor component of tonic ... Centers for Disease Control and Prevention (April 1991). "Treatment with quinidine gluconate of persons with severe Plasmodium ... September 2005). "Effects of quinine, quinidine, and chloroquine on alpha9alpha10 nicotinic cholinergic receptors". Molecular ...
Disopyramide
... 's Class 1a activity is similar to that of quinidine in that it targets sodium channels to inhibit conduction. ... Quinidine, procainamide and disopyramide". Drug Safety. 5 (6): 393-420. doi:10.2165/00002018-199005060-00002. PMID 2285495. ... in higher doses compared to quinidine. Levites proposed a possible secondary mode of action for disopyramide, against reentrant ... "Effects of intravenous disopyramide and quinidine on normal myocardium and on the characteristics of arrhythmias: ...
Encainide
Dykstra SJ, Minielli JL, Lawson JE, Ferguson HC, Dungan KW (September 1973). "Lysergic acid and quinidine analogs. 2-(o- ...
Antimalarial medication
Quinimax and quinidine are the two most commonly used alkaloids related to quinine in the treatment or prevention of malaria. ... Quinidine is a direct derivative of quinine. It is a distereoisomer, thus having similar anti-malarial properties to the parent ... Quinidine is recommended only for the treatment of severe cases of malaria. Warburg's tincture was a febrifuge developed by ... Quinimax is a combination of four alkaloids (quinine, quinidine, cinchonine and cinchonidine). This combination has been shown ...
Trihexyphenidyl
Quinidine : Increased anticholinergic action (particular on AV conduction). Antipsychotics : Long term use of trihexyphenidyl ...
Biperiden
Quinidine : Increased anticholinergic action (particular on AV conduction). Antipsychotics : Long-term use of biperiden may ...
Sodium channel blocker
While procainamide and quinidine may be used in the conversion of atrial fibrillation to normal sinus rhythm, they should only ... Class Ia agents include quinidine, procainamide and disopyramide. Class Ib antiarrhythmic agents are sodium channel blockers. ... because procainamide and quinidine can increase the conduction through the AV node and may cause 1:1 conduction of atrial ...
Tetrandrine
It has a quinidine-like anti-arrhythmic effect. It has vasodilatory properties and can therefore reduce blood pressure. ...
Cardioversion
Procainamide, quinidine and disopyramide are Class Ia agents. Class 1b drugs lengthen phase 3 repolarization. They include ...
Cinchona
Two more key alkaloids, quinidine and cinchonidine, were later identified and it became a routine in quinology to examine the ... The bark contains alkaloids, including quinine and quinidine. Cinchona is the only economically practical source of quinine, a ... Cinchona alkaloids include: cinchonine and cinchonidine (stereoisomers with R1 = vinyl, R2 = hydrogen) quinine and quinidine ( ...
Loperamide
... taken with quinidine was found to produce respiratory depression, indicative of central opioid action. Loperamide ... Concurrent administration of P-glycoprotein inhibitors such as quinidine potentially allows loperamide to cross the blood-brain ... Common P-glycoprotein inhibitors include quinidine, ritonavir, and ketoconazole. Loperamide is capable of decreasing the ...
Chlorpromazine
Quinidine may interact with chlorpromazine to increase myocardial depression. Likewise, it may also antagonize the effects of ... Other drugs that prolong the QT interval, such as quinidine, verapamil, amiodarone, sotalol and methadone, may also interact ...
Cholinergic blocking drugs
Medications indicated for: Irregular heartbeat, e.g. disopyramide, quinidine. Drug-induced arrhythmia worsened by ...
Amikacin
Quinidine also increases levels of amikacin in the body. The NSAID indomethacin can increase serum aminoglycoside levels in ...
Dextrorphan
Relevance to dextromethorphan/quinidine (Nuedexta®) clinical use". Pharmacol. Ther. 164: 170-82. doi:10.1016/j.pharmthera. ...
Procainamide
Due to the loss of Indonesia in World War II, the source for cinchona alkaloids, a precursor of quinidine, was reduced. This ... As a result, procaine was discovered, which has similar cardiac effects as quinidine. In 1936 it was found by Mautz that by ... These were the cardiac glycosides, quinidine, propranolol, lidocaine and diphenylhydantoin. In January 1996, extended release ... but it had the same toxicity profile as quinidine, and it could cause systemic lupus erythematosus-like syndrome. These ...
Deep hypothermic circulatory arrest
Woodhall B, Sealy WC, Hall KD, Floyd WL (July 1960). "Craniotomy under conditions of quinidine-protected cardioplegia and ... Woodhall B, Sealy WC, Hall KD, Floyd WL (July 1960). "Craniotomy under conditions of quinidine-protected cardioplegia and ... Woodhall B, Sealy WC, Hall KD, Floyd WL (July 1960). "Craniotomy under conditions of quinidine-protected cardioplegia and ...
Acetazolamide
Quinidine, reduces urinary excretion of quinidine, hence increasing the potential for toxicity. Salicylates, potential for ...
Amaurosis
Quinidine toxicity can lead to cinchonism and also to quinine amaurosis.[citation needed] Those experiencing amaurosis are ...
Cinchona officinalis
Other alkaloids that are extracted from this tree include cinchonine, cinchonidine and quinidine. Standley, Paul C. (1936). " ...
Potassium channel blocker
Drugs such as quinidine may be both reverse use dependent and use dependent. Examples of calcium-activated channel blockers ... Reverse use dependent drugs that slow heart rate (such as quinidine) can be less effective at high heart rates. The ... such as quinidine) are more efficacious at preventing a tachyarrhythmia than converting someone into normal sinus rhythm.[ ... Bupivacaine Quinidine Fluoxetine Seproxetine (Norfluoxetine) 12-O-tetradecanoylphorbol-13-acetate (TPA) (phorbol 12-myristate ...
Porphyria cutanea tarda
Protoporphyrin IX Complexes of the Antimalarial Cinchona Alkaloids Quinine and Quinidine". ACS Chemical Biology. 7 (4): 666-71 ...
Isoprenaline
"Electrical storms in Brugada syndrome successfully treated with isoproterenol infusion and quinidine orally". Netherlands Heart ...
Pindolol
... shows membrane-stabilizing effects like quinidine, possibly accounting for its antiarrhythmic effects. It also acts as ...
Fluconazole
... concomitant administration of fluconazole and quinidine, especially when fluconazole is administered in high dosages; take ...
Baylis-Hillman reaction
β-ICD, a cinchona alkaloid derivative, is famous among the quinidine framework-based catalysts. 1,1,1,3,3,3,- ...
Barium cyanide
... and Quinidine". Annual Review of Pharmacology and Toxicology. 16: 189-99. doi:10.1146/annurev.pa.16.040176.001201. PMID 779614 ...
Worldwide Quinidine Shortage
As reported previously by heartwire , the absence of quinidine is posing problems for physicians, some of whom are forced to ... TEL AVIV, ISRAEL - Quinidine, a drug that is used by electrophysiologists to treat Brugada syndrome, is available worldwide in ... The researchers note that one of the quinidine brands available in the US is made in India, yet its not available to Indian ... "Quinidine is the only oral medication that has consistently shown efficacy in preventing arrhythmias and terminating arrhythmic ...
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The pharmaceutical manufacturer of quinidine, Eli Lilly, recently announcedExternal. that it will no longer be producing IV ... As of today, intravenous quinidine gluconate remains available for the treatment of severe malaria. CDC and FDA are developing ... quinidine gluconate, but plans to continue distributing the product until the current stock expires (March 2019). ...
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Quinidine-induced hypotension that is not due to an arrhythmia is likely to be a consequence of quinidine-related α-blockade ... Therapy with quinidine sulfate should be begun with 200 mg (equivalent to 166 mg of quinidine base) every six hours. If this ... Quinidine has no clinically significant effect on the pharmacokinetics of or Non-interactions of quinidine with other drugs: ... Quinidine sulfate is the sulfate salt of quinidine; its chemical name is cinchonan-9-ol, 6-methoxy-, (9 )-, sulfate(2:1) ...
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Quinidine: learn about side effects, dosage, special precautions, and more on MedlinePlus ... Quinidine comes as a tablet (quinidine sulfate) and an extended-release (long-acting) tablet (quinidine gluconate) to take by ... Quinidine helps control your condition but will not cure it. Continue to take quinidine even if you feel well. Do not stop ... Before taking quinidine,. *tell your doctor and pharmacist if you are allergic to quinidine, quinine, or any other drugs. ...
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Quinidine Quinidine is used to treat certain types of irregular heartbeats. Quinidine is in a class of medications called ... Dextromethorphan and Quinidine The combination of dextromethorphan and quinidine is used to treat pseudobulbar affect (PBA; a ... mL (17.00 to 42.50 micromol/L) Quinidine: 2 to 5 mcg/mL (6.16 to ... than 16 mcg/mL (68.00 micromol/L) Quinidine: greater than ... decrease how fast the body gets rid of quinidine. Drinking grapefruit juice while taking quinidine might increase the chance of ...
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Quinidine-induced liver disease A Deisseroth et al. Ann Intern Med. 1972 Oct. ... Quinidine-induced granulomatous hepatitis. Chajek T, Lehrer B, Geltner D, Levij IS. Chajek T, et al. Ann Intern Med. 1974 Dec; ... Quinidine hypersensitivity: a side effect of a forgotten antiarrhythmic. El-Khatib L, Alrayes H, Sallam O, Elbanna A. El-Khatib ...
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Quinidine has been associated with fever, mild jaundice and clinically apparent liver injury in up to 2% of treated patients. ... Quinidine is a natural cinchona alkaloid which has potent antiarrhythmic activity and has been used for decades in the ... The Role of Quinidine in the Pharmacological Therapy of Ventricular Arrhythmias Quinidine. Bozic B, Uzelac TV, Kezic A, ... only amiodarone and quinidine are common causes of hepatotoxicity; quinidine has been associated with many cases of clinically ...
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Comparison of Flecainide with Quinidine for Suppression of Chronic Stable Ventricular Ectopic DepolarizationsA Double-Blind...
Flecainide prolonged the PR and QRS intervals; quinidine prolonged the PR and JTC intervals. Side effects were commoner with ... The mean percent suppression of total ventricular ectopic depolarizations was 95% for flecainide and 56% for quinidine (p , ... SALERNO DM, HODGES M, GRANRUD G, SHARKEY P. Comparison of Flecainide with Quinidine for Suppression of Chronic Stable ... Comparison of Flecainide with Quinidine for Suppression of Chronic Stable Ventricular Ectopic Depolarizations: A Double-Blind ...
Oxidation of quinidine by human liver cytochrome P-450. | Molecular Pharmacology
Thus, quinidine oxidation appears to be catalyzed primarily by P-450NF and not by P-450DB. Quinidine binds 2 orders of ... Oxidation of quinidine by human liver cytochrome P-450.. F P Guengerich, D Müller-Enoch and I A Blair ... Oxidation of quinidine by human liver cytochrome P-450.. F P Guengerich, D Müller-Enoch and I A Blair ... Oxidation of quinidine by human liver cytochrome P-450.. F P Guengerich, D Müller-Enoch and I A Blair ...
Altered Absorption of Digoxin, Sustained-Release Quinidine, and Warfarin with Sucralfate Administration | Semantic Scholar
... quinidine, and warfarin. Patients receiving sucralfate concomitantly with digoxin, quinidine, and warfarin should be monitored ... A case is reported of a 71-year-old woman who displayed altered absorption of digoxin, quinidine sulfate, and warfarin sodium ... The administration of sucralfate resulted in subtherapeutic serum concentrations of digoxin and quinidine, and also reduced the ... quinidine, and warfarin should be monitored frequently with regard to serum drug concentration and disease symptomatology. ...
Treatment of Malaria with a Short Course of Quinidine in: The American Journal of Tropical Medicine and Hygiene Volume s1-15...
In this report are included observations on the treatment of malaria in 1,047 cases over a period of five years, 1930 to 1934, inclusive. Most of the patients were plantation negroes, the rest, whites, representing all strata of society from the plantation owner to the poorest tenant farmer. These people remain in the district year after year and can be followed up for malaria season after season.. The practice is located near Shreveport, Louisiana, and in the Red River Valley. The area involved is considered moderately malarious.. Collins (1) recently reported "surprisingly satisfactory" results from treatment of clinical malaria with 1 gram of quinine sulphate a day for three or four days.. These results are not new, except in details. In the year 1868 Wade reported to the Madras Chinchona Commission (2) on 1079 cases of clinical malaria treated with quinine, quinidine, cinchonidine and cinchonine. ...
THE DIFFERENTIAL EFFECT OF QUINIDINE AND PYRILAMINE ON THE MYOCARDIAL ACTION POTENTIAL AT VARIOUS RATES OF STIMULATION |...
THE DIFFERENTIAL EFFECT OF QUINIDINE AND PYRILAMINE ON THE MYOCARDIAL ACTION POTENTIAL AT VARIOUS RATES OF STIMULATION. E. A. ... THE DIFFERENTIAL EFFECT OF QUINIDINE AND PYRILAMINE ON THE MYOCARDIAL ACTION POTENTIAL AT VARIOUS RATES OF STIMULATION. E. A. ... THE DIFFERENTIAL EFFECT OF QUINIDINE AND PYRILAMINE ON THE MYOCARDIAL ACTION POTENTIAL AT VARIOUS RATES OF STIMULATION. E. A. ... In the presence of quinidine sulphate (10 microgm./ml.) or pyrilamine maleate (7.5 microgm./ml.) a) the progressive decline in ...
Clinical Implications of the Competitive Inhibition of the Debrisoquin-Metabolizing Isozyme by Quinidine, Archives of Internal...
Quinidine administration changes persons to poor metabolizers of debrisoquin for the duration of therapy. Thus, the use of ... Quinidine and the identification of drugs whose elimination is impaired in subjects classified as poor metabolizers of ... Two distinct quinidine-induced rheumatic syndromes . Ann Intern Med. 1988;108:369-371.Crossref 117. Kendall MJ, Hawkins CF. ... Single dose quinidine treatment inhibits metoprolol oxidation in extensive metabolizers . Eur J Clin Pharmacol. 1986;29:739-741 ...
DailyMed - QUINIDINE SULFATE tablet
... equivalent to 166 mg of quinidine base) 300 mg of quinidine sulfate (equivalent to 249 mg of quinidine base). In addition, each ... Quinidine-induced hypotension that is not due to an arrhythmia is likely to be a consequence of quinidine-related α-blockade ... Therapy with quinidine sulfate should be begun with 200 mg (equivalent to 166 mg of quinidine base) every six hours. If this ... Quinidine sulfate is the sulfate salt of quinidine; its chemical name is cinchonan-9-ol,6- methoxy-,(9S)-, sulfate(2:1) ...
Wolff-Parkinson-White Syndrome Medication: Antiarrhythmic Agents
Risks of Quinidine during pregnancy
Quinidine Gluconate Injection (Quinidine Injection)- Multum
... Посетила Quinidine Gluconate Injection (Quinidine Injection)- ... Quinidine Injection)- Multum grouping of one or several nodes, each Quinidine Gluconate Injection (Quinidine Injection)- Multum ... The sole Quinidine Gluconate Injection (Quinidine Injection)- Multum for the content of this webpage lies with ELIXIR. It does ... It is an observer and is working towards Quinidine Gluconate Injection (Quinidine Injection)- Multum membership (see How ...
Digoxin-Quinidine Interaction<...
title = "Digoxin-Quinidine Interaction",. abstract = "To the Editor: We should like to comment on the paper by Hager et al.1 ... Digoxin-Quinidine Interaction. Rune Dahlqvist, Gunnar Ejvinsson, Karin Schenck-Gustafsson, W. David Hager, Paul Fenster, ... Digoxin-Quinidine Interaction. / Dahlqvist, Rune; Ejvinsson, Gunnar; Schenck-Gustafsson, Karin; Hager, W. David; Fenster, Paul ... To the Editor: We should like to comment on the paper by Hager et al.1 concerning the interaction between quinidine and digoxin ...
Dextromethorphan/Quinidine for Managing Respiratory Impairment in ALS - Pulmonology Advisor
Dextromethorphan/quinidine was not shown to prevent failure of noninvasive respiratory management in patients with amyotrophic ... Sancho J, Ferrer S, Burés E, et al. Effect of one-year dextromethorphan/quinidine treatment on management of respiratory ... In patients with amyotrophic lateral sclerosis (ALS), treatment with dextromethorphan/quinidine (DM/Q) was not shown to prevent ... Investigators evaluated whether dextromethorphan/quinidine could offer long-term improvement in bulbar impairment in ...
NIFEDIPINE CAPSULES, USP
Quinidine (56-54-2) | Chemical Effects in Biological Systems
Genetic Toxicity Evaluation of Quinidine in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 022129 Summary Data. * G06 ... Genetic Toxicity Evaluation of Quinidine in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 266846 Summary Data. * G06 ... Quinidine (56-54-2). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology ... An overview of Genetic Toxicology Bacterial Mutagenicity study conclusions related to Quinidine (56-54-2). Bacterial ...
NDC 42806-513 Quinidine Sulfate Quinidine Sulfate Tablet
The generic name of Quinidine Sulfate is quinidine sulfate tablet. ... Quinidine Sulfate with NDC 42806-513 is a a human prescription drug product labeled by Epic Pharma, Llc. ... equivalent to 166 mg of quinidine base) 300 mg of quinidine sulfate (equivalent to 249 mg of quinidine base). In addition, each ... Quinidine-induced hypotension that is not due to an arrhythmia is likely to be a consequence of quinidine-related α-blockade ...
Quinaglute (Quinidine Gluconate) Basics, Side Effects & Reviews - Iodine.com
Quinidine Gluconate); from expert pharmacists and people like you ... Quinidine Gluconate. ? Write a. review!. Worth it. Not sure. ... Quinaglute (Quinidine Gluconate). 0 reports. These are side effects of. Quinaglute (Quinidine Gluconate) reported to the FDA by ... Quinidine gluconate. at all.. *Percentages only tell you how common an issue is for people who actually make the effort to ... Quinaglute (Quinidine Gluconate). questions for. Select an indication to see answers for that use case. Atrial Fibrillation/ ...
Possible Interaction: Quinidine and Tetracaine - SUPP.AI by AI2
Buy Quinaglute Dura Tabs (quinidine gluconate) Online | Blink Health
Quinidine is very similar to quinine. Do not use medications containing quinine while using quinidine. ... Other medications can affect the removal of quinidine from your body, which may affect how quinidine works. Examples include ... Before taking quinidine, tell your doctor or pharmacist if you are allergic to it; or to quinine; or if you have any other ... Before using quinidine, tell your doctor or pharmacist of all the drugs you take and if you have any of the following ...
Quinidine in Tamil பயன்பாடுகள், மருந்தளவு, பக்க விளைவுகள், நன்மைகள், தொடர்புகள் மற்றும் எச்சரிக்கைகள்
Quinidine in Tamil - ன் பயன்பாடுகள், மருந்தளவு, பக்க விளைவுகள், நன்மைகள், தொடர்புகள் மற்றும் எச்சரிக்கைகள் ஆகியவற்றை ... Quinidine பக்க விளைவுகள் - Quinidine Side Effects in Tamil- Quinidine pakka vilaivugal * Quinidine தொடர்புடைய எச்சரிக்கைகள் - ... Quinidine நன்மைகள் & பயன்கள் - Quinidine Benefits & Uses in Tamil- Quinidine nanmaigal & payangal * Quinidine மருந்தளவு & ... Quinidine முரண்பாடுகள் - Quinidine Contraindications in Tamil- Quinidine muranpaadugal * Quinidine பற்றி அடிக்கடி கேட்கப்படும் ...
QuinineCombination of dextromethorphan and quinidineGluconateIntravenousMalariaDextromethorphanLoading dose of quinidinePropafenoneDisopyramideAdministration of quinidineAntiarrhythmicTake quinidinePlus quinidineDoseInhibitorAmiodaroneDigoxinPhenobarbitalSulfate tabletsDrugsSulphateMedicationIrregular200mgTorsadesTabletsAtrial flutterConcentrationsCompoundEnzymeEfficacyPregnantMedicationsDrugInteractPharmacistRisks
Quinine6
- tell your doctor and pharmacist if you are allergic to quinidine, quinine, or any other drugs. (medlineplus.gov)
- Stereoselective inhibition by the diastereomers quinidine and quinine of uptake of cardiac glycosides into isolated rat hepatocytes. (semanticscholar.org)
- Quinine, the diastereomer of quinidine, has not been as extensively studied in this respect. (semanticscholar.org)
- Quinine and quinidine are diastereomers. (sielc.com)
- a history of bruising or bleeding after using quinidine or quinine. (everydayhealth.com)
- OR malarone OR mefloquine OR naphthoquine OR naphthoquinone OR piperaquine OR primaquine OR proguanil OR pyrimethamine OR pyronaridine OR proguanil OR quinidine OR quinine OR riamet OR sulphadoxine OR tetracycline OR tafenoquine). (cdc.gov)
Combination of dextromethorphan and quinidine2
- A combination of dextromethorphan and quinidine has been shown to alleviate symptoms of easy laughing and crying (pseudobulbar affect) in patients with amyotrophic lateral sclerosis and multiple sclerosis. (ncats.io)
- April 13, 2010 (Toronto, Ontario) - Results of an open-label extension study examining the effect of a combination of dextromethorphan and quinidine ( Zenvia , Avanir Pharmaceuticals) confirm continued efficacy of this still investigational combination in the treatment of pseudobulbar affect (PBA). (medscape.com)
Gluconate8
- Quinidine comes as a tablet (quinidine sulfate) and an extended-release (long-acting) tablet (quinidine gluconate) to take by mouth. (medlineplus.gov)
- Extended-release quinidine gluconate tablets are usually is taken every 8 to 12 hours. (medlineplus.gov)
- The pharmaceutical manufacturer of quinidine, Eli Lilly, recently announced External that it will no longer be producing IV quinidine gluconate, but plans to continue distributing the product until the current stock expires (March 2019). (cdc.gov)
- As of today, intravenous quinidine gluconate remains available for the treatment of severe malaria. (cdc.gov)
- Currently, quinidine gluconate is the only FDA approved medicine in the United States for the treatment of severe malaria. (cdc.gov)
- The evaluation was requested by the local union to investigate work related skin rashes and respiratory symptoms among employees involved in producing quinidine-gluconate (7054253). (cdc.gov)
- After 3 blood transfusions and quinidine improper use of blood glucometers, multidose heparin gluconate and doxycycline therapy, the patient was dis- vials, organ transplantation, contaminated catheters that charged on hospital day 14, with a stable hematocrit, per- deliver contrast medium, or rarely, open wounds (3-6). (cdc.gov)
- Patient 1 received a continuous quinidine gluconate documented. (cdc.gov)
Intravenous2
- Intravenous quinidine is also indicated for the treatment of Plasmodium falciparum malaria. (ncats.io)
- However, it fails to mention the critical importance of having intravenous (IV) quinidine available for the management of life-threatening chloroquine-resistant Plasmodium falciparum infection. (jamanetwork.com)
Malaria4
- Quinidine is also sometimes used to treat malaria. (medlineplus.gov)
- Albrecht H, Lennox J, del Rio C. Quinidine and Malaria. (jamanetwork.com)
- Quinidine is also used to treat a life-threatening form of malaria. (everydayhealth.com)
- 1 Photolichenoid dermatitis was first described in 1954 in association with the use of quinidine in the treatment of malaria. (web.app)
Dextromethorphan14
- In these studies, we examined the effects of CYP2D6 phenotype and quinidine inhibition on the pharmacokinetics of dextromethorphan and its metabolites in humans. (erowid.org)
- Pretreatment of these subjects with 100 mg of quinidine, a selective inhibitor of CYP2D6, significantly suppressed the formation of dextrorphan and elevated the concentrations of dextromethorphan (t1/2, 16.4 hours). (erowid.org)
- Urinary recovery studies indicated that the inhibition by quinidine was reversible and that the elimination of dextromethorphan primarily depends on CYP2D6 activity rather than renal elimination. (erowid.org)
- These data demonstrated that the CYP2D6 phenotype and the concurrent administration of quinidine significantly affect the disposition of dextromethorphan and the formation of the active metabolite dextrorphan and are important factors to be considered in studies of the pharmacologic and behavioral effects of dextromethorphan. (erowid.org)
- A small, proof-of-concept study suggests dextromethorphan with quinidine may be a future treatment option for levodopa-induced dyskinesia (LID) in patients with Parkinson's disease (PD). (neurologyadvisor.com)
- Of note, dextromethorphan is thought to have an impact on all three of these pathways, and combining dextromethorphan with quinidine increases the bioavailability of dextromethorphan by inhibiting CYP2D6. (neurologyadvisor.com)
- Susan H. Fox, MB ChB, MRCP(UK), Ph, associate director of the movement disorders clinic at the University Health Network in Toronto, Canada, and colleagues sought to examine the efficacy and safety of dextromethorphan with quinidine for LID. (neurologyadvisor.com)
- The participants were randomly assigned to receive either dextromethorphan 45 mg plus quinidine 10 mg twice daily or placebo during 2 2-week crossover treatment periods. (neurologyadvisor.com)
- In the 13 efficacy-evaluable participants, there was no significant difference in dyskinesia-severity for dextromethorphan with quinidine compared with placebo (area under the curve [AUC] 966.5 vs 1048.8, P =.191). (neurologyadvisor.com)
- Trial of dextromethorphan/quinidine to treat levodopa-induced dyskinesia in Parkinson's disease [published online March 30, 2017]. (neurologyadvisor.com)
- Quinidine increases plasma levels of dextromethorphan by competitively inhibiting cytochrome P4502D6, which catalyzes a major biotransformation pathway for dextromethorphan. (medscape.com)
- It is available as a capsule containing dextromethorphan 20 mg and quinidine 10 mg. (medscape.com)
- The new drug is a combination of 2 well-known compounds: dextromethorphan, the active treatment, and quinidine, an enzyme inhibitor that increases the bioavailability of dextromethorphan. (medscape.com)
- All were then treated during the 12-week extension study with the 30/10-mg dose of dextromethorphan and quinidine, regardless of whether they were in the active or placebo-treated arms during the randomized trial. (medscape.com)
Loading dose of quinidine1
- 2 The administration of a loading dose of quinidine to convert atrial fibrillation has such a pronounced proarrhythmic effect that it is advised against in recent guidelines for clinical practice on atrial fibrillation 3 (class IIb indication). (revespcardiol.org)
Propafenone1
- Asymptomatic phases of atrial flutter with greater-than-or-equal-to 2:1 atrio-ventricular conduction ratio were observed during Holter monitoring, before conversion to sinus rhythm, in four patients treated with propafenone, in one patient taking digoxin plus quinidine and in four patients with placebo. (unimore.it)
Disopyramide2
- Inform your doctor if you are taking monoamine oxidase inhibitors, aliskiren, quinidine, disopyramide, or other blood pressure-lowering medicines. (apollopharmacy.in)
- Avoid the class IA antidysrhythmics quinidine and disopyramide, due to prodysrhythmic and QT interval-prolonging effects. (medscape.com)
Administration of quinidine1
- All the deaths were sudden and associated with the administration of quinidine in high doses (1000-2000 mg/day). (revespcardiol.org)
Antiarrhythmic6
- Taking antiarrhythmic drugs, including quinidine, may increase the risk of death. (medlineplus.gov)
- Quinidine is in a class of medications called antiarrhythmic medications. (medlineplus.gov)
- Quinidine is a pharmaceutical agent that acts as a class I antiarrhythmic agent (Ia) in the heart. (ncats.io)
- Like all other class I antiarrhythmic agents, quinidine primarily works by blocking the fast inward sodium current (INa). (ncats.io)
- Conclusions: Antiarrhythmic efficacy of dofetilide was greater than that of quinidine and correlated with drug-induced prolongation of wavelength and reduction in dispersion of refractoriness, effects produced only by dofetilide. (elsevier.com)
- Listed below are medications that increase the urinary excretion of magnesium, promoting magnesium loss: Drugs used in heart disease Antiarrhythmic Drugs Quinidine, Sotalol, Aamiodarone, Bretylium Digoxin and Strophanthin Adrenalin and drugs that mimic its activity, such as isoproterenol Diuretics Furosemide Ethacrynic Acid Thiazides Osmotic Agents. (reuther-hartmann.de)
Take quinidine5
- Take quinidine at around the same times every day. (medlineplus.gov)
- Take quinidine exactly as directed. (medlineplus.gov)
- Continue to take quinidine even if you feel well. (medlineplus.gov)
- Your doctor may tell you not to take quinidine. (medlineplus.gov)
- Can I take quinidine sulphate in case of kidney disorder? (theindianpharma.com)
Plus quinidine1
- Digoxin and digoxin plus quinidine, at the doses employed, had a lower success rate and more prolonged conversion times. (unimore.it)
Dose6
- On separate occasions 6 extensive metabolizers of sparteine took a single oral dose of 100 mg imipramine and desipramine before and during the intake of quinidine sulphate 200 mg/day. (nih.gov)
- The pharmacokinetic interaction between quinidine and digoxin in patients is well-known, in general requiring a dose reduction of digoxin in patients concomitantly treated with quinidine. (semanticscholar.org)
- The STAR trial was undertaken to address previous concerns of the US Food and Drug Administration (FDA) about safety issues with a formulation of the compound that used a higher dose of quinidine, concerns outlined in an earlier approvable letter issued in 2006. (medscape.com)
- The previous combination of these drugs had used a 30-mg dose of quinidine, raising concern about the potential for proarrhythmia, Dr. Pioro said. (medscape.com)
- Dose-related cinchonism may be the first sign of quinidine toxicity. (pursuantmedia.com)
- Your blood pressure and heart rate should be monitored in a hospital or clinic setting when you start using quinidine, and whenever your dose is changed. (everydayhealth.com)
Inhibitor2
- It appears that quinidine is a potent inhibitor of the sparteine/debrisoquine oxygenase, P450dbl, which is responsible for the 2-hydroxylation of imipramine and desipramine, but not of the P450 isozyme responsible for the demethylation of imipramine. (nih.gov)
- Quinidine is also an inhibitor of the cytochrome P450 enzyme 2D6 and can lead to increased blood levels of lidocaine, beta blockers, opioids, and some antidepressants. (ncats.io)
Amiodarone1
- Substrate of P-gp hence shows increased levels when co-administered with quinidine and amiodarone. (medicineplexus.com)
Digoxin1
- In addition to an interaction with the renal clearance of digoxin by quinidine, both diastereomers have been reported to inhibit the biliary clearance of digoxin in man. (semanticscholar.org)
Phenobarbital1
- Quinidine, a hydantoin anticonvulsant is used alone or with phenobarbital or other anticonvulsants to treat tonic-clonic seizures, psycho-motor seizures, neuropathic pain syndromes including Diabetic neuropathy, atrial fibrillation and flutter, vent. (medicoinfo.org)
Sulfate tablets3
- Quinidine sulfate tablets are usually is taken every 6 hours. (medlineplus.gov)
- The quinidine sulfate tablets should be taken as you have been instructed by your doctor or other health care provider. (theindianpharma.com)
- The Indian Pharma provides the guarantee of quality as well as delivery for the Quinidine Sulfate Tablets. (theindianpharma.com)
Drugs2
- Quinidine also inhibits the transport protein P-glycoprotein and so can cause some peripherally acting drugs such as loperamide to have central nervous system side effects, such as respiratory depression if the two drugs are coadministered. (ncats.io)
- quinidine, or chronic nonsteroidal anti-inflammatory drugs. (who.int)
Sulphate3
- The quinidine sulphate 200mg is not recommended for the treatment of patients suffering from nocturnal leg cramps. (theindianpharma.com)
- What are the uses of quinidine sulphate? (theindianpharma.com)
- The quinidine sulphate 200mg price is very reasonable. (theindianpharma.com)
Medication2
- Quinidine sulfate falls under the group of medication named antiarrhythmics. (theindianpharma.com)
- Quinidine may also be used for purposes not listed in this medication guide. (everydayhealth.com)
Irregular5
- Quinidine may increase the chance of having arrhythmias (irregular heartbeats) and has not been proven to help people without life-threatening arrhythmias to live longer. (medlineplus.gov)
- Quinidine is used to treat certain types of irregular heartbeats. (medlineplus.gov)
- Quinidine can greatly improve your ability to perform normal activities by decreasing the number of irregular heartbeats you have. (blinkhealth.com)
- If you are taking regular-release quinidine for an irregular heartbeat, the manufacturer recommends that you take no more than 4 grams daily. (blinkhealth.com)
- Quinidine Sulfate is recommended to be used in order to treat/prevent several types of irregular heartbeats. (theindianpharma.com)
200mg1
- The quinidine sulfate 200mg should be kept in a well-closed container, protected from light. (theindianpharma.com)
Torsades1
- Quinidine can cause thrombocytopenia, granulomatous hepatitis, myasthenia gravis, and torsades de pointes, so is not used much today. (ncats.io)
Tablets1
- Quinidine tablets should be taken whole even without crushing or chewing. (theindianpharma.com)
Atrial flutter3
- Methods and Results: To test this hypothesis, the Class III drug dofetilide and the Class IA drug quinidine were studied in the experimental canine crush-injury model of atrial flutter, utilizing right atrial multipoint programmed stimulation and activation mapping. (elsevier.com)
- Dofetilide and quinidine terminated atrial flutter by similar mechanisms. (elsevier.com)
- Quinidine maintains normal heart rhythm and converts AF or atrial flutter. (medscape.com)
Concentrations2
Compound2
- Quinidine - Isomeric methoxyl compound. (abchomeopathy.com)
- Quinidine was used as the sample compound for the development of this methodology though the intent was not to set an OEL for quinidine but rather to develop an alternative approach for the determination of OELs. (cdc.gov)
Enzyme1
- turmeric will increase the level or effect of quinidine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. (medscape.com)
Efficacy1
- Efficacy of dofetilide was greater than quinidine (P = 0.026) and correlated with reduced dispersion of ERP (r = -0.653, P = 0.01), reduced adjacent electrodes with ERP difference ≤ 20 msec (r = -0.637, P = 0.012), and prolonged wavelength (r = 0.61, P = 0.018). (elsevier.com)
Pregnant2
- If you become pregnant while taking quinidine, call your doctor. (medlineplus.gov)
- No, quinidine sulfate over the counter drug is not advised in the case of pregnant women as it can cause potential damage to unborn babies as well as to the mother. (theindianpharma.com)
Medications2
- Many other medications may also interact with quinidine, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list. (medlineplus.gov)
- Before and while you are using quinidine, your doctor may prescribe other medications (e.g., 'blood thinners'/anticoagulants such as warfarin, beta blockers such as metoprolol) to shrink any blood clots in the heart and to slow your pulse. (blinkhealth.com)
Drug2
Interact1
- Grapefruit may interact with oral quinidine and lead to unwanted side effects. (everydayhealth.com)
Pharmacist1
- Do not change quinidine products without talking to your doctor or pharmacist. (blinkhealth.com)
Risks3
- Talk to your doctor about the risks of taking quinidine. (medlineplus.gov)
- Quinidine has not been proven to lower the risks of stroke or death. (everydayhealth.com)
- Ask your doctor about the risks and benefits of using quinidine. (everydayhealth.com)