A system for verifying and maintaining a desired level of quality in a product or process by careful planning, use of proper equipment, continued inspection, and corrective action as required. (Random House Unabridged Dictionary, 2d ed)
A generic concept reflecting concern with the modification and enhancement of life attributes, e.g., physical, political, moral and social environment; the overall condition of a human life.
The levels of excellence which characterize the health service or health care provided based on accepted standards of quality.
Activities and programs intended to assure or improve the quality of care in either a defined medical setting or a program. The concept includes the assessment or evaluation of the quality of care; identification of problems or shortcomings in the delivery of care; designing activities to overcome these deficiencies; and follow-up monitoring to ensure effectiveness of corrective steps.
Norms, criteria, standards, and other direct qualitative and quantitative measures used in determining the quality of health care.
A system of cisternae in the CYTOPLASM of many cells. In places the endoplasmic reticulum is continuous with the plasma membrane (CELL MEMBRANE) or outer membrane of the nuclear envelope. If the outer surfaces of the endoplasmic reticulum membranes are coated with ribosomes, the endoplasmic reticulum is said to be rough-surfaced (ENDOPLASMIC RETICULUM, ROUGH); otherwise it is said to be smooth-surfaced (ENDOPLASMIC RETICULUM, SMOOTH). (King & Stansfield, A Dictionary of Genetics, 4th ed)
Processes involved in the formation of TERTIARY PROTEIN STRUCTURE.
The statistical reproducibility of measurements (often in a clinical context), including the testing of instrumentation or techniques to obtain reproducible results. The concept includes reproducibility of physiological measurements, which may be used to develop rules to assess probability or prognosis, or response to a stimulus; reproducibility of occurrence of a condition; and reproducibility of experimental results.
Facilities equipped to carry out investigative procedures.
A lectin found in ENDOPLASMIC RETICULUM membranes that binds to specific N-linked OLIGOSACCHARIDES found on newly synthesized proteins. It may play role in PROTEIN FOLDING or retention and degradation of misfolded proteins in the endoplasmic reticulum.
A family of cellular proteins that mediate the correct assembly or disassembly of polypeptides and their associated ligands. Although they take part in the assembly process, molecular chaperones are not components of the final structures.
A basis of value established for the measure of quantity, weight, extent or quality, e.g. weight standards, standard solutions, methods, techniques, and procedures used in diagnosis and therapy.
The attainment or process of attaining a new level of performance or quality.
The application of industrial management practice to systematically maintain and improve organization-wide performance. Effectiveness and success are determined and assessed by quantitative quality measures.
A large multisubunit complex that plays an important role in the degradation of most of the cytosolic and nuclear proteins in eukaryotic cells. It contains a 700-kDa catalytic sub-complex and two 700-kDa regulatory sub-complexes. The complex digests ubiquitinated proteins and protein activated via ornithine decarboxylase antizyme.
A rating of a body of water based on measurable physical, chemical, and biological characteristics.
The specialty of ANALYTIC CHEMISTRY applied to assays of physiologically important substances found in blood, urine, tissues, and other biological fluids for the purpose of aiding the physician in making a diagnosis or following therapy.
Predetermined sets of questions used to collect data - clinical data, social status, occupational group, etc. The term is often applied to a self-completed survey instrument.
Cleavage of proteins into smaller peptides or amino acids either by PROTEASES or non-enzymatically (e.g., Hydrolysis). It does not include Protein Processing, Post-Translational.
A multifunctional protein that is found primarily within membrane-bound organelles. In the ENDOPLASMIC RETICULUM it binds to specific N-linked oligosaccharides found on newly-synthesized proteins and functions as a MOLECULAR CHAPERONE that may play a role in PROTEIN FOLDING or retention and degradation of misfolded proteins. In addition calreticulin is a major storage form for CALCIUM and functions as a calcium-signaling molecule that can regulate intracellular calcium HOMEOSTASIS.
Techniques used to carry out clinical investigative procedures in the diagnosis and therapy of disease.
The process of moving proteins from one cellular compartment (including extracellular) to another by various sorting and transport mechanisms such as gated transport, protein translocation, and vesicular transport.
Hospital facilities equipped to carry out investigative procedures.
A degradation process whereby incorrectly folded proteins are selectively transported out of the ENDOPLASMIC RETICULUM and into the CYTOSOL. The misfolded proteins are subsequently ubiquitinated and degraded by the PROTEASOME.
A highly conserved 76-amino acid peptide universally found in eukaryotic cells that functions as a marker for intracellular PROTEIN TRANSPORT and degradation. Ubiquitin becomes activated through a series of complicated steps and forms an isopeptide bond to lysine residues of specific proteins within the cell. These "ubiquitinated" proteins can be recognized and degraded by proteosomes or be transported to specific compartments within the cell.
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
Ratings of the characteristics of food including flavor, appearance, nutritional content, and the amount of microbial and chemical contamination.
Sequential operating programs and data which instruct the functioning of a digital computer.
A diverse class of enzymes that interact with UBIQUITIN-CONJUGATING ENZYMES and ubiquitination-specific protein substrates. Each member of this enzyme group has its own distinct specificity for a substrate and ubiquitin-conjugating enzyme. Ubiquitin-protein ligases exist as both monomeric proteins multiprotein complexes.
A subspecialty of pathology applied to the solution of clinical problems, especially the use of laboratory methods in clinical diagnosis. (Dorland, 28th ed.)
An intracellular ribonucleolytic protein complex that participates in POSTRANSCRIPTIONAL RNA PROCESSING and RNA DEGRADATION.
Elements of limited time intervals, contributing to particular results or situations.
A procedure consisting of a sequence of algebraic formulas and/or logical steps to calculate or determine a given task.
Proteins obtained from the species SACCHAROMYCES CEREVISIAE. The function of specific proteins from this organism are the subject of intense scientific interest and have been used to derive basic understanding of the functioning similar proteins in higher eukaryotes.
The act of ligating UBIQUITINS to PROTEINS to form ubiquitin-protein ligase complexes to label proteins for transport to the PROTEASOME ENDOPEPTIDASE COMPLEX where proteolysis occurs.
The segregation and degradation of damaged or unwanted cytoplasmic constituents by autophagic vacuoles (cytolysosomes) composed of LYSOSOMES containing cellular components in the process of digestion; it plays an important role in BIOLOGICAL METAMORPHOSIS of amphibians, in the removal of bone by osteoclasts, and in the degradation of normal cell components in nutritional deficiency states.
Procedures for collecting, preserving, and transporting of specimens sufficiently stable to provide accurate and precise results suitable for clinical interpretation.
Any tests that demonstrate the relative efficacy of different chemotherapeutic agents against specific microorganisms (i.e., bacteria, fungi, viruses).
A species of the genus SACCHAROMYCES, family Saccharomycetaceae, order Saccharomycetales, known as "baker's" or "brewer's" yeast. The dried form is used as a dietary supplement.
A family of enzymes that catalyze the exonucleolytic cleavage of RNA. It includes EC 3.1.13.-, EC 3.1.14.-, EC 3.1.15.-, and EC 3.1.16.-. EC 3.1.-
The extent to which an RNA molecule retains its structural integrity and resists degradation by RNASE, and base-catalyzed HYDROLYSIS, under changing in vivo or in vitro conditions.
Determination, by measurement or comparison with a standard, of the correct value of each scale reading on a meter or other measuring instrument; or determination of the settings of a control device that correspond to particular values of voltage, current, frequency or other output.
Proteolytic breakdown of the MITOCHONDRIA.
A plan for collecting and utilizing data so that desired information can be obtained with sufficient precision or so that an hypothesis can be tested properly.
Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.
Health care professionals, technicians, and assistants staffing LABORATORIES in research or health care facilities.
A system of traditional medicine which is based on the beliefs and practices of the Chinese culture.
The chemical or biochemical addition of carbohydrate or glycosyl groups to other chemicals, especially peptides or proteins. Glycosyl transferases are used in this biochemical reaction.
Disorders caused by imbalances in the protein homeostasis network - synthesis, folding, and transport of proteins; post-translational modifications; and degradation or clearance of misfolded proteins.
Proteins which are synthesized in eukaryotic organisms and bacteria in response to hyperthermia and other environmental stresses. They increase thermal tolerance and perform functions essential to cell survival under these conditions.
Studies determining the effectiveness or value of processes, personnel, and equipment, or the material on conducting such studies. For drugs and devices, CLINICAL TRIALS AS TOPIC; DRUG EVALUATION; and DRUG EVALUATION, PRECLINICAL are available.
Hybridization of a nucleic acid sample to a very large set of OLIGONUCLEOTIDE PROBES, which have been attached individually in columns and rows to a solid support, to determine a BASE SEQUENCE, or to detect variations in a gene sequence, GENE EXPRESSION, or for GENE MAPPING.
Glycoside hydrolases that catalyze the hydrolysis of alpha or beta linked MANNOSE.
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
A stack of flattened vesicles that functions in posttranslational processing and sorting of proteins, receiving them from the rough ENDOPLASMIC RETICULUM and directing them to secretory vesicles, LYSOSOMES, or the CELL MEMBRANE. The movement of proteins takes place by transfer vesicles that bud off from the rough endoplasmic reticulum or Golgi apparatus and fuse with the Golgi, lysosomes or cell membrane. (From Glick, Glossary of Biochemistry and Molecular Biology, 1990)
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
A class of MOLECULAR CHAPERONES found in both prokaryotes and in several compartments of eukaryotic cells. These proteins can interact with polypeptides during a variety of assembly processes in such a way as to prevent the formation of nonfunctional structures.
Theoretical representations that simulate the behavior or activity of biological processes or diseases. For disease models in living animals, DISEASE MODELS, ANIMAL is available. Biological models include the use of mathematical equations, computers, and other electronic equipment.
A loose confederation of computer communication networks around the world. The networks that make up the Internet are connected through several backbone networks. The Internet grew out of the US Government ARPAnet project and was designed to facilitate information exchange.
A cellular response to environmental insults that cause disruptions in PROTEIN FOLDING and/or accumulation of defectively folded protein in the ENDOPLASMIC RETICULUM. It consists of a group of regulatory cascades that are triggered as a response to altered levels of calcium and/or the redox state of the endoplasmic reticulum. Persistent activation of the unfolded protein response leads to the induction of APOPTOSIS.
A systematic statement of policy rules or principles. Guidelines may be developed by government agencies at any level, institutions, professional societies, governing boards, or by convening expert panels. The text may be cursive or in outline form but is generally a comprehensive guide to problems and approaches in any field of activity. For guidelines in the field of health care and clinical medicine, PRACTICE GUIDELINES AS TOPIC is available.
Linear POLYPEPTIDES that are synthesized on RIBOSOMES and may be further modified, crosslinked, cleaved, or assembled into complex proteins with several subunits. The specific sequence of AMINO ACIDS determines the shape the polypeptide will take, during PROTEIN FOLDING, and the function of the protein.
Systematic gathering of data for a particular purpose from various sources, including questionnaires, interviews, observation, existing records, and electronic devices. The process is usually preliminary to statistical analysis of the data.
Method of measuring performance against established standards of best practice.
A subspecialty of internal medicine concerned with morphology, physiology, and pathology of the blood and blood-forming tissues.
The presence of organisms, or any foreign material that makes a drug preparation impure.
Liquid chromatographic techniques which feature high inlet pressures, high sensitivity, and high speed.
The science and art of collecting, summarizing, and analyzing data that are subject to random variation. The term is also applied to the data themselves and to the summarization of the data.
A quality-of-life scale developed in the United States in 1972 as a measure of health status or dysfunction generated by a disease. It is a behaviorally based questionnaire for patients and addresses activities such as sleep and rest, mobility, recreation, home management, emotional behavior, social interaction, and the like. It measures the patient's perceived health status and is sensitive enough to detect changes or differences in health status occurring over time or between groups. (From Medical Care, vol.xix, no.8, August 1981, p.787-805)
Chinese herbal or plant extracts which are used as drugs to treat diseases or promote general well-being. The concept does not include synthesized compounds manufactured in China.
The failure by the observer to measure or identify a phenomenon accurately, which results in an error. Sources for this may be due to the observer's missing an abnormality, or to faulty technique resulting in incorrect test measurement, or to misinterpretation of the data. Two varieties are inter-observer variation (the amount observers vary from one another when reporting on the same material) and intra-observer variation (the amount one observer varies between observations when reporting more than once on the same material).
The level of health of the individual, group, or population as subjectively assessed by the individual or by more objective measures.
The determination of the pattern of genes expressed at the level of GENETIC TRANSCRIPTION, under specific circumstances or in a specific cell.
The interaction of persons or groups of persons representing various nations in the pursuit of a common goal or interest.
Any of various enzymatically catalyzed post-translational modifications of PEPTIDES or PROTEINS in the cell of origin. These modifications include carboxylation; HYDROXYLATION; ACETYLATION; PHOSPHORYLATION; METHYLATION; GLYCOSYLATION; ubiquitination; oxidation; proteolysis; and crosslinking and result in changes in molecular weight and electrophoretic motility.
Studies in which the presence or absence of disease or other health-related variables are determined in each member of the study population or in a representative sample at one particular time. This contrasts with LONGITUDINAL STUDIES which are followed over a period of time.
Application of statistical procedures to analyze specific observed or assumed facts from a particular study.
A multistage process that includes cloning, physical mapping, subcloning, determination of the DNA SEQUENCE, and information analysis.
Research aimed at assessing the quality and effectiveness of health care as measured by the attainment of a specified end result or outcome. Measures include parameters such as improved health, lowered morbidity or mortality, and improvement of abnormal states (such as elevated blood pressure).
Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.
The degree to which the individual regards the health care service or product or the manner in which it is delivered by the provider as useful, effective, or beneficial.
The continuous remodeling of MITOCHONDRIA shape by fission and fusion in response to physiological conditions.
Conjugated protein-carbohydrate compounds including mucins, mucoid, and amyloid glycoproteins.
Proteins which are found in membranes including cellular and intracellular membranes. They consist of two types, peripheral and integral proteins. They include most membrane-associated enzymes, antigenic proteins, transport proteins, and drug, hormone, and lectin receptors.
A scientific or medical discipline concerning the study of male reproductive biology, diseases of the male genital organs, and male infertility. Major areas of interest include ENDOCRINOLOGY; SPERMATOGENESIS; semen analysis; FERTILIZATION; CONTRACEPTION; and CRYOPRESERVATION.
A family of heat-shock proteins that contain a 70 amino-acid consensus sequence known as the J domain. The J domain of HSP40 heat shock proteins interacts with HSP70 HEAT-SHOCK PROTEINS. HSP40 heat-shock proteins play a role in regulating the ADENOSINE TRIPHOSPHATASES activity of HSP70 heat-shock proteins.
Commercially prepared reagent sets, with accessory devices, containing all of the major components and literature necessary to perform one or more designated diagnostic tests or procedures. They may be for laboratory or personal use.
The ability of a protein to retain its structural conformation or its activity when subjected to physical or chemical manipulations.
Electronic instruments that produce photographs or cathode-ray tube images of the gamma-ray emissions from organs containing radionuclide tracers.
Centers for acquiring, characterizing, and storing organs or tissue for future use.
The chemical and physical integrity of a pharmaceutical product.
Semiautonomous, self-reproducing organelles that occur in the cytoplasm of all cells of most, but not all, eukaryotes. Each mitochondrion is surrounded by a double limiting membrane. The inner membrane is highly invaginated, and its projections are called cristae. Mitochondria are the sites of the reactions of oxidative phosphorylation, which result in the formation of ATP. They contain distinctive RIBOSOMES, transfer RNAs (RNA, TRANSFER); AMINO ACYL T RNA SYNTHETASES; and elongation and termination factors. Mitochondria depend upon genes within the nucleus of the cells in which they reside for many essential messenger RNAs (RNA, MESSENGER). Mitochondria are believed to have arisen from aerobic bacteria that established a symbiotic relationship with primitive protoeukaryotes. (King & Stansfield, A Dictionary of Genetics, 4th ed)
Assessments aimed at determining agreement in diagnostic test results among laboratories. Identical survey samples are distributed to participating laboratories, with results stratified according to testing methodologies.
An mRNA metabolic process that distinguishes a normal STOP CODON from a premature stop codon (NONSENSE CODON) and facilitates rapid degradation of aberrant mRNAs containing premature stop codons.
A prokaryotic ATP-dependent protease that plays a role in the degradation of many abnormal proteins. It is a tetramer of 87-kDa subunits, each of which contains a proteolytic site and a ATP-binding site.
Any visible result of a procedure which is caused by the procedure itself and not by the entity being analyzed. Common examples include histological structures introduced by tissue processing, radiographic images of structures that are not naturally present in living tissue, and products of chemical reactions that occur during analysis.
Participation of employees with management as a labor-management team, in decisions pertaining to the operational activities of the organization or industry.
Sulfur-sulfur bond isomerases that catalyze the rearrangement of disulfide bonds within proteins during folding. Specific protein disulfide-isomerase isoenzymes also occur as subunits of PROCOLLAGEN-PROLINE DIOXYGENASE.
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
The level of protein structure in which combinations of secondary protein structures (alpha helices, beta sheets, loop regions, and motifs) pack together to form folded shapes called domains. Disulfide bridges between cysteines in two different parts of the polypeptide chain along with other interactions between the chains play a role in the formation and stabilization of tertiary structure. Small proteins usually consist of only one domain but larger proteins may contain a number of domains connected by segments of polypeptide chain which lack regular secondary structure.
Proteins produced from GENES that have acquired MUTATIONS.
An examination of chemicals in the blood.
Movement characteristics of SPERMATOZOA in a fresh specimen. It is measured as the percentage of sperms that are moving, and as the percentage of sperms with productive flagellar motion such as rapid, linear, and forward progression.
Controlled operations of analytic or diagnostic processes, or systems by mechanical or electronic devices.
That component of SPEECH which gives the primary distinction to a given speaker's VOICE when pitch and loudness are excluded. It involves both phonatory and resonatory characteristics. Some of the descriptions of voice quality are harshness, breathiness and nasality.
Data processing largely performed by automatic means.
Proteases that contain proteolytic core domains and ATPase-containing regulatory domains. They are usually comprised of large multi-subunit assemblies. The domains can occur within a single peptide chain or on distinct subunits.
The study of microorganisms such as fungi, bacteria, algae, archaea, and viruses.
Any liquid or solid preparation made specifically for the growth, storage, or transport of microorganisms or other types of cells. The variety of media that exist allow for the culturing of specific microorganisms and cell types, such as differential media, selective media, test media, and defined media. Solid media consist of liquid media that have been solidified with an agent such as AGAR or GELATIN.
The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments.
Directions or principles presenting current or future rules of policy for assisting health care practitioners in patient care decisions regarding diagnosis, therapy, or related clinical circumstances. The guidelines may be developed by government agencies at any level, institutions, professional societies, governing boards, or by the convening of expert panels. The guidelines form a basis for the evaluation of all aspects of health care and delivery.
Certification as complying with a standard set by non-governmental organizations, applied for by institutions, programs, and facilities on a voluntary basis.
Works about clinical trials that involve at least one test treatment and one control treatment, concurrent enrollment and follow-up of the test- and control-treated groups, and in which the treatments to be administered are selected by a random process, such as the use of a random-numbers table.
Enzymes that catalyze the exohydrolysis of 1,4-alpha-glucosidic linkages with release of alpha-glucose. Deficiency of alpha-1,4-glucosidase may cause GLYCOGEN STORAGE DISEASE TYPE II.
The thick, yellowish-white, viscid fluid secretion of male reproductive organs discharged upon ejaculation. In addition to reproductive organ secretions, it contains SPERMATOZOA and their nutrient plasma.
The integration of epidemiologic, sociological, economic, and other analytic sciences in the study of health services. Health services research is usually concerned with relationships between need, demand, supply, use, and outcome of health services. The aim of the research is evaluation, particularly in terms of structure, process, output, and outcome. (From Last, Dictionary of Epidemiology, 2d ed)
A field of biology concerned with the development of techniques for the collection and manipulation of biological data, and the use of such data to make biological discoveries or predictions. This field encompasses all computational methods and theories for solving biological problems including manipulation of models and datasets.
Assessment of psychological variables by the application of mathematical procedures.
A detailed review and evaluation of selected clinical records by qualified professional personnel for evaluating quality of medical care.
Procedures for finding the mathematical function which best describes the relationship between a dependent variable and one or more independent variables. In linear regression (see LINEAR MODELS) the relationship is constrained to be a straight line and LEAST-SQUARES ANALYSIS is used to determine the best fit. In logistic regression (see LOGISTIC MODELS) the dependent variable is qualitative rather than continuously variable and LIKELIHOOD FUNCTIONS are used to find the best relationship. In multiple regression, the dependent variable is considered to depend on more than a single independent variable.
A count of SPERM in the ejaculum, expressed as number per milliliter.
One of the three domains of life (the others being Eukarya and ARCHAEA), also called Eubacteria. They are unicellular prokaryotic microorganisms which generally possess rigid cell walls, multiply by cell division, and exhibit three principal forms: round or coccal, rodlike or bacillary, and spiral or spirochetal. Bacteria can be classified by their response to OXYGEN: aerobic, anaerobic, or facultatively anaerobic; by the mode by which they obtain their energy: chemotrophy (via chemical reaction) or PHOTOTROPHY (via light reaction); for chemotrophs by their source of chemical energy: CHEMOLITHOTROPHY (from inorganic compounds) or chemoorganotrophy (from organic compounds); and by their source for CARBON; NITROGEN; etc.; HETEROTROPHY (from organic sources) or AUTOTROPHY (from CARBON DIOXIDE). They can also be classified by whether or not they stain (based on the structure of their CELL WALLS) with CRYSTAL VIOLET dye: gram-negative or gram-positive.
Controlled operation of an apparatus, process, or system by mechanical or electronic devices that take the place of human organs of observation, effort, and decision. (From Webster's Collegiate Dictionary, 1993)
A species of gram-negative, facultatively anaerobic, rod-shaped bacteria (GRAM-NEGATIVE FACULTATIVELY ANAEROBIC RODS) commonly found in the lower part of the intestine of warm-blooded animals. It is usually nonpathogenic, but some strains are known to produce DIARRHEA and pyogenic infections. Pathogenic strains (virotypes) are classified by their specific pathogenic mechanisms such as toxins (ENTEROTOXIGENIC ESCHERICHIA COLI), etc.
The portion of an interactive computer program that issues messages to and receives commands from a user.
Proteins encoded by the mitochondrial genome or proteins encoded by the nuclear genome that are imported to and resident in the MITOCHONDRIA.
Drugs intended for human or veterinary use, presented in their finished dosage form. Included here are materials used in the preparation and/or formulation of the finished dosage form.
Works about controlled studies which are planned and carried out by several cooperating institutions to assess certain variables and outcomes in specific patient populations, for example, a multicenter study of congenital anomalies in children.
The edible portions of any animal used for food including domestic mammals (the major ones being cattle, swine, and sheep) along with poultry, fish, shellfish, and game.
A second-generation cephalosporin administered intravenously or intramuscularly. Its bactericidal action results from inhibition of cell wall synthesis. It is used for urinary tract infections, lower respiratory tract infections, and soft tissue and bone infections.
Methods of creating machines and devices.
A mass spectrometry technique using two (MS/MS) or more mass analyzers. With two in tandem, the precursor ions are mass-selected by a first mass analyzer, and focused into a collision region where they are then fragmented into product ions which are then characterized by a second mass analyzer. A variety of techniques are used to separate the compounds, ionize them, and introduce them to the first mass analyzer. For example, for in GC-MS/MS, GAS CHROMATOGRAPHY-MASS SPECTROMETRY is involved in separating relatively small compounds by GAS CHROMATOGRAPHY prior to injecting them into an ionization chamber for the mass selection.
An amino acid-specifying codon that has been converted to a stop codon (CODON, TERMINATOR) by mutation. Its occurance is abnormal causing premature termination of protein translation and results in production of truncated and non-functional proteins. A nonsense mutation is one that converts an amino acid-specific codon to a stop codon.
Extensive collections, reputedly complete, of facts and data garnered from material of a specialized subject area and made available for analysis and application. The collection can be automated by various contemporary methods for retrieval. The concept should be differentiated from DATABASES, BIBLIOGRAPHIC which is restricted to collections of bibliographic references.
The biosynthesis of PEPTIDES and PROTEINS on RIBOSOMES, directed by MESSENGER RNA, via TRANSFER RNA that is charged with standard proteinogenic AMINO ACIDS.
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.
Solid dosage forms, of varying weight, size, and shape, which may be molded or compressed, and which contain a medicinal substance in pure or diluted form. (Dorland, 28th ed)
Complexes of RNA-binding proteins with ribonucleic acids (RNA).
Conformity in fulfilling or following official, recognized, or institutional requirements, guidelines, recommendations, protocols, pathways, or other standards.
Substances used for the detection, identification, analysis, etc. of chemical, biological, or pathologic processes or conditions. Indicators are substances that change in physical appearance, e.g., color, at or approaching the endpoint of a chemical titration, e.g., on the passage between acidity and alkalinity. Reagents are substances used for the detection or determination of another substance by chemical or microscopical means, especially analysis. Types of reagents are precipitants, solvents, oxidizers, reducers, fluxes, and colorimetric reagents. (From Grant & Hackh's Chemical Dictionary, 5th ed, p301, p499)
Studies to determine the advantages or disadvantages, practicability, or capability of accomplishing a projected plan, study, or project.
A general term for single-celled rounded fungi that reproduce by budding. Brewers' and bakers' yeasts are SACCHAROMYCES CEREVISIAE; therapeutic dried yeast is YEAST, DRIED.
The unfavorable effect of environmental factors (stressors) on the physiological functions of an organism. Prolonged unresolved physiological stress can affect HOMEOSTASIS of the organism, and may lead to damaging or pathological conditions.
A plant genus of the family RANUNCULACEAE. Members contain SCOPOLETIN and SAPONINS.
A complex sulfated polymer of galactose units, extracted from Gelidium cartilagineum, Gracilaria confervoides, and related red algae. It is used as a gel in the preparation of solid culture media for microorganisms, as a bulk laxative, in making emulsions, and as a supporting medium for immunodiffusion and immunoelectrophoresis.
The conversion of uncharged TRANSFER RNA to AMINO ACYL TRNA.
Members of the class of compounds composed of AMINO ACIDS joined together by peptide bonds between adjacent amino acids into linear, branched or cyclical structures. OLIGOPEPTIDES are composed of approximately 2-12 amino acids. Polypeptides are composed of approximately 13 or more amino acids. PROTEINS are linear polypeptides that are normally synthesized on RIBOSOMES.
A method of comparing the cost of a program with its expected benefits in dollars (or other currency). The benefit-to-cost ratio is a measure of total return expected per unit of money spent. This analysis generally excludes consideration of factors that are not measured ultimately in economic terms. Cost effectiveness compares alternative ways to achieve a specific set of results.
Statistical models in which the value of a parameter for a given value of a factor is assumed to be equal to a + bx, where a and b are constants. The models predict a linear regression.
A class of morphologically heterogeneous cytoplasmic particles in animal and plant tissues characterized by their content of hydrolytic enzymes and the structure-linked latency of these enzymes. The intracellular functions of lysosomes depend on their lytic potential. The single unit membrane of the lysosome acts as a barrier between the enzymes enclosed in the lysosome and the external substrate. The activity of the enzymes contained in lysosomes is limited or nil unless the vesicle in which they are enclosed is ruptured. Such rupture is supposed to be under metabolic (hormonal) control. (From Rieger et al., Glossary of Genetics: Classical and Molecular, 5th ed)
A transfer RNA which is specific for carrying cysteine to sites on the ribosomes in preparation for protein synthesis.
The genetic constitution of the individual, comprising the ALLELES present at each GENETIC LOCUS.
Positive test results in subjects who do not possess the attribute for which the test is conducted. The labeling of healthy persons as diseased when screening in the detection of disease. (Last, A Dictionary of Epidemiology, 2d ed)
The measurement of the health status for a given population using a variety of indices, including morbidity, mortality, and available health resources.
Small-scale tests of methods and procedures to be used on a larger scale if the pilot study demonstrates that these methods and procedures can work.
Levels within a diagnostic group which are established by various measurement criteria applied to the seriousness of a patient's disorder.
Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.
Studies designed to assess the efficacy of programs. They may include the evaluation of cost-effectiveness, the extent to which objectives are met, or impact.
Measurement and evaluation of the components of substances to be taken as FOOD.
Hereditary and sporadic conditions which are characterized by progressive nervous system dysfunction. These disorders are often associated with atrophy of the affected central or peripheral nervous system structures.
The property of objects that determines the direction of heat flow when they are placed in direct thermal contact. The temperature is the energy of microscopic motions (vibrational and translational) of the particles of atoms.
Statistical formulations or analyses which, when applied to data and found to fit the data, are then used to verify the assumptions and parameters used in the analysis. Examples of statistical models are the linear model, binomial model, polynomial model, two-parameter model, etc.
Databases devoted to knowledge about specific genes and gene products.
An analysis comparing the allele frequencies of all available (or a whole GENOME representative set of) polymorphic markers in unrelated patients with a specific symptom or disease condition, and those of healthy controls to identify markers associated with a specific disease or condition.
The application of scientific knowledge or technology to pharmacy and the pharmaceutical industry. It includes methods, techniques, and instrumentation in the manufacture, preparation, compounding, dispensing, packaging, and storing of drugs and other preparations used in diagnostic and determinative procedures, and in the treatment of patients.
The arrangement of two or more amino acid or base sequences from an organism or organisms in such a way as to align areas of the sequences sharing common properties. The degree of relatedness or homology between the sequences is predicted computationally or statistically based on weights assigned to the elements aligned between the sequences. This in turn can serve as a potential indicator of the genetic relatedness between the organisms.
Institutions with an organized medical staff which provide medical care to patients.
Substances that reduce the growth or reproduction of BACTERIA.
Chemistry dealing with the composition and preparation of agents having PHARMACOLOGIC ACTIONS or diagnostic use.
Post-transcriptional biological modification of messenger, transfer, or ribosomal RNAs or their precursors. It includes cleavage, methylation, thiolation, isopentenylation, pseudouridine formation, conformational changes, and association with ribosomal protein.
A generic term for any circumscribed mass of foreign (e.g., lead or viruses) or metabolically inactive materials (e.g., ceroid or MALLORY BODIES), within the cytoplasm or nucleus of a cell. Inclusion bodies are in cells infected with certain filtrable viruses, observed especially in nerve, epithelial, or endothelial cells. (Stedman, 25th ed)
Enzymes that catalyze the transfer of glucose from a nucleoside diphosphate glucose to an acceptor molecule which is frequently another carbohydrate. EC 2.4.1.-.
Laboratory and other services provided to patients at the bedside. These include diagnostic and laboratory testing using automated information entry.
A single nucleotide variation in a genetic sequence that occurs at appreciable frequency in the population.
Evaluation procedures that focus on both the outcome or status (OUTCOMES ASSESSMENT) of the patient at the end of an episode of care - presence of symptoms, level of activity, and mortality; and the process (ASSESSMENT, PROCESS) - what is done for the patient diagnostically and therapeutically.
An agency of the PUBLIC HEALTH SERVICE established in 1990 to "provide indexing, abstracting, translating, publishing, and other services leading to a more effective and timely dissemination of information on research, demonstration projects, and evaluations with respect to health care to public and private entities and individuals engaged in the improvement of health care delivery..." It supersedes the National Center for Health Services Research. The United States Agency for Health Care Policy and Research was renamed Agency for Healthcare Research and Quality (AHRQ) under the Healthcare Research and Quality Act of 1999.
Organized activities related to the storage, location, search, and retrieval of information.
Techniques of nucleotide sequence analysis that increase the range, complexity, sensitivity, and accuracy of results by greatly increasing the scale of operations and thus the number of nucleotides, and the number of copies of each nucleotide sequenced. The sequencing may be done by analysis of the synthesis or ligation products, hybridization to preexisting sequences, etc.
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
A group of enzymes which catalyze the hydrolysis of ATP. The hydrolysis reaction is usually coupled with another function such as transporting Ca(2+) across a membrane. These enzymes may be dependent on Ca(2+), Mg(2+), anions, H+, or DNA.
One of the BASIC-LEUCINE ZIPPER TRANSCRIPTION FACTORS that is synthesized as a membrane-bound protein in the ENDOPLASMIC RETICULUM. In response to endoplasmic reticulum stress it translocates to the GOLGI APPARATUS. It is activated by PROTEASES and then moves to the CELL NUCLEUS to regulate GENETIC TRANSCRIPTION of GENES involved in the unfolded protein response.
Established cell cultures that have the potential to propagate indefinitely.
The monitoring of the level of toxins, chemical pollutants, microbial contaminants, or other harmful substances in the environment (soil, air, and water), workplace, or in the bodies of people and animals present in that environment.
The taking of a blood sample to determine its character as a whole, to identify levels of its component cells, chemicals, gases, or other constituents, to perform pathological examination, etc.
Models used experimentally or theoretically to study molecular shape, electronic properties, or interactions; includes analogous molecules, computer-generated graphics, and mechanical structures.
Techniques used in studying bacteria.
Methodologies used for the isolation, identification, detection, and quantitation of chemical substances.
Systematic organization, storage, retrieval, and dissemination of specialized information, especially of a scientific or technical nature (From ALA Glossary of Library and Information Science, 1983). It often involves authenticating or validating information.
Incorrect diagnoses after clinical examination or technical diagnostic procedures.
A semisynthetic cephamycin antibiotic that is administered intravenously or intramuscularly. The drug is highly resistant to a broad spectrum of beta-lactamases and is active against a wide range of both aerobic and anaerobic gram-positive and gram-negative microorganisms.
A specialty field of radiology concerned with diagnostic, therapeutic, and investigative use of radioactive compounds in a pharmaceutical form.
A statistical technique that isolates and assesses the contributions of categorical independent variables to variation in the mean of a continuous dependent variable.
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
A constitutively expressed subfamily of the HSP70 heat-shock proteins. They preferentially bind and release hydrophobic peptides by an ATP-dependent process and are involved in post-translational PROTEIN TRANSLOCATION.
Proteins obtained from ESCHERICHIA COLI.

Preclinical safety evaluation of human gene therapy products. (1/4780)

Human gene therapy products include naked DNA and viral as well as non-viral vectors containing nucleic acids. There is limited experience on the preclinical toxicity studies necessary for the safety evaluation of these products, which have been outlined in several recently released guidelines. Requirements for the preclinical safety evaluation of human gene therapy products are both specific and non-specific. All key preclinical studies should be performed in compliance with Good Laboratory Practices. Non-specific requirements are in fact common to all pharmaceutical products. Critical specific issues to be addressed are: the safety evaluation of the vector and the toxicity of the expressed protein(s), which are the two components of gene therapy products, the quality of the test article, the selection of animal species, and the verification that the administration method successfully transports the gene of interest, with the vector, to the target site(s). The treatment schedule should mimic the intended human therapeutic design. The host's immune response against the gene therapy product has to be evaluated to detect possible adverse effects and immune neutralization by antibodies. The biodistribution of the gene of interest is also essential and can be evaluated by molecular biology techniques, such as PCR. Specific confinement is required for the safe manipulation of viral vectors.  (+info)

Accuracy of application of USDA beef quality and yield grades using the traditional system and the proposed seven-grade yield grade system. (2/4780)

Beef carcasses (n = 5,542) were evaluated by three USDA on-line graders and compared with the computed expert USDA quality (QG) and yield grades (YG) during 8-h shifts at a major beef-processing facility for a 2-wk period to evaluate the accuracy of applying USDA QG and YG within the traditional five-grade and the proposed seven-grade (segregating YG 2 and 3 into YG 2A, 2B, 3A, and 3B) YG systems. Quality grade distribution of the carcasses was 1.1% Prime, 50.0% Choice, 43.8% Select, and 5.1% No-Roll. Accuracy of applying QG was not affected (P>.05) by changing from the five-grade (91.5%) to either the seven-grade system, when determining only QG (94.3%), or the seven-grade system, when determining QG and YG (95.0%). Calculated expert YG successfully segregated carcasses into their respective YG, but on-line graders could not differentiate between YG 4 and 5 in the seven-grade systems. The application of YG in the five-grade system was more accurate (P<.05) than either of the seven-grade systems. A trend existed for on-line graders to undergrade carcasses as the numerical YG increased. Total accuracy of applying YG decreased by 19.4 to 21.8% when switching from the five-grade to the seven-grade system. The segmentation of USDA YG 2 and 3 into YG 2A, 2B, 3A, and 3B resulted in a decrease in the ability of on-line graders to accurately apply the YG.  (+info)

Validation of measures of food insecurity and hunger. (3/4780)

The most recent survey effort to determine the extent of food insecurity and hunger in the United States, the Food Security Supplement, included a series of questions to assess this complex phenomenon. The primary measure developed from this Food Security Supplement was based on measurement concepts, methods and items from two previously developed measures. This paper presents the evidence available that questionnaire-based measures, in particular the national food security measure, provide valid measurement of food insecurity and hunger for population and individual uses. The paper discusses basic ideas about measurement and criteria for establishing validity of measures and then uses these criteria to structure an examination of the research results available to establish the validity of food security measures. The results show that the construction of the national food security measure is well grounded in our understanding of food insecurity and hunger, its performance is consistent with that understanding, it is precise within usual performance standards, dependable, accurate at both group and individual levels within reasonable performance standards, and its accuracy is attributable to the well-grounded understanding. These results provide strong evidence that the Food Security Supplement provides valid measurement of food insecurity and hunger for population and individual uses. Further validation research is required for subgroups of the population, not yet studied for validation purposes, to establish validity for monitoring population changes in prevalence and to develop and validate robust and contextually sensitive measures in a variety of countries that reflect how people experience and think about food insecurity and hunger.  (+info)

An assessment of the operation of an external quality assessment (EQA) scheme in histopathology in the South Thames (West) region: 1995-1998. (4/4780)

AIMS: To describe the design and organisation of a voluntary regional external quality assessment (EQA) scheme in histopathology, and to record the results obtained over a three year period. METHODS: A protocol is presented in which circulation of EQA slides alternated with teaching sessions. Procedures for the choice of suitable cases, evaluation of submitted diagnoses, and feedback of results to participants are described. The use of teaching sessions, complementary to the slide circulations, and dealing with current diagnostic problems is also outlined. RESULTS: Participation rates in the nine slide circulations varied between 66% and 89%, mean 85%. Overall scores were predictably high but 4% of returns, from 10 pathologists, were unsatisfactory. These low scores were typically isolated or intermittent and none of the participants fulfilled agreed criteria for chronic poor performers. CONCLUSIONS: This scheme has been well supported and overall performances have been satisfactory. The design was sufficiently discriminatory to reveal a few low scores which are analysed in detail. Prompt feedback of results to participants with identification of all "incomplete" and "wrong" diagnoses is essential. Involvement of local histopathologists in designing, running, and monitoring such schemes is important.  (+info)

European interlaboratory comparison of breath 13CO2 analysis. (5/4780)

The BIOMED I programme Stable Isotopes in Gastroenterology and Nutrition (SIGN) has focused upon evaluation and standardisation of stable isotope breath tests using 13C labelled substrates. The programme dealt with comparison of 13C substrates, test meals, test conditions, analysis techniques, and calculation procedures. Analytical techniques applied for 13CO2 analysis were evaluated by taking an inventory of instrumentation, calibration protocols, and analysis procedures. Two ring tests were initiated measuring 13C abundances of carbonate materials. Evaluating the data it was found that seven different models of isotope ratio mass spectrometers (IRMS) were used by the participants applying both the dual inlet system and the continuous flow configuration. Eight different brands of certified 13C reference materials were used with a 13C abundance varying from delta 13CPDB -37.2 to +2.0/1000. CO2 was liberated from certified material by three techniques and different working standards were used varying from -47.4 to +0.4/1000 in their delta 13CPDB value. The standard deviations (SDs) found for all measurements by all participants were 0.25/1000 and 0.50/1000 for two carbonates used in the ring tests. The individual variation for the single participants varied from 0.02 /1000 (dual inlet system) to 0.14/1000 (continuous flow system). The measurement of the difference between two carbonates showed a SD of 0.33/1000 calculated for all participants. Internal precision of IRMS as indicated by the specifications of the different instrument suppliers is < 0.3/1000 for continuous flow systems. In this respect it can be concluded that all participants are working well within the instrument specifications even including sample preparation. Increased overall interlaboratory variation is therefore likely to be due to non-instrumental conditions. It is possible that consistent differences in sample handling leading to isotope fractionation are the causes for interlaboratory variation. Breath analysis does not require sample preparation. As such, interlaboratory variation will be less than observed for the carbonate samples and within the range indicated as internal precision for continuous flow instruments. From this it is concluded that pure analytical interlaboratory variation is acceptable despite the many differences in instrumentation and analytical protocols. Coordinated metabolic studies appear possible, in which different European laboratories perform 13CO2 analysis. Evaluation of compatibility of the analytical systems remains advisable, however.  (+info)

A policy of quality control assessment helps to reduce the risk of intraoperative stroke during carotid endarterectomy. (6/4780)

OBJECTIVES: A pilot study in our unit suggested that a combination of transcranial Doppler (TCD) plus completion angioscopy reduced incidence of intra-operative stroke (i.e. patients recovering from anaesthesia with a new deficit) during carotid endarterectomy (CEA). The aim of the current study was to see whether routine implementation of this policy was both feasible and associated with a continued reduction in the rate of intraoperative stroke (IOS). MATERIALS AND METHODS: Prospective study in 252 consecutive patients undergoing carotid endarterectomy between March 1995 and December 1996. RESULTS: Continuous TCD monitoring was possible in 229 patients (91%), while 238 patients (94%) underwent angioscopic examination. Overall, angioscopy identified an intimal flap requiring correction in six patients (2.5%), whilst intraluminal thrombus was removed in a further six patients (2.5%). No patient in this series recovered from anaesthesia with an IOS, but the rate of postoperative stroke was 2.8%. CONCLUSIONS: Our policy of TCD plus angioscopy has continued to contribute towards a sustained reduction in the risk of IOS following CEA, but requires access to reliable equipment and technical support. However, a policy of intraoperative quality control assessment may not necessarily alter the rate of postoperative stroke.  (+info)

Effect of different lots of Mueller-Hinton agar on the interpretation of the gentamicin susceptibility of Pseudomonas aeruginosa. (7/4780)

Population distributions and quality control data for strains of Pseudomonas aeruginosa tested for gentamicin susceptibility on six lots of Mueller-Hinton agar were analyzed. The lots of agar were used in three University of Washington hospitals from April 1975 through October 1977. The analyses indicated that the performance of members of the P. aeruginosa populations in each hospital closely followed the performance of the quality control strain, P. aeruginosa ATCC 27853, when tested on each lot of Mueller-Hinton medium. The variability of zone diameters with the P. aeruginosa populations and the quality control strain indicated that a fixed indeterminate range (13 to 16 mm) of gentamicin susceptibility was not applicable to these organisms as it was with the Enterobacteriaceae. Variability in gentamicin susceptibility results was demonstrated in both minimal inhibitory concentration and disk diffusion tests when eight selected P. aeruginosa strains and the quality control strain were tested on each lot of medium. This variation in susceptibility to gentamicin was not related to the total Ca(2+), Mg(2+), or Zn(2+) content of each lot of medium. The data demonstrated that a moving indeterminate range of gentamicin susceptibility, 3 to 6 mm below the mean zone diameter of the quality control strain, was a suitable criterion for strains tested on a single medium lot. These results illustrate the importance of defining stringent performance standards for media used in the susceptibility testing of P. aeruginosa with gentamicin and other aminoglycoside antibiotics.  (+info)

A new method of developing expert consensus practice guidelines. (8/4780)

To improve the quality of medical care while reducing costs, it is necessary to standardize best practice habits at the most crucial clinical decision points. Because many pertinent questions encountered in everyday practice are not well answered by the available research, expert consensus is a valuable bridge between clinical research and clinical practice. Previous methods of developing expert consensus have been limited by their relative lack of quantification, specificity, representativeness, and implementation. This article describes a new method of developing, documenting, and disseminating expert consensus guidelines that meets these concerns. This method has already been applied to four disorders in psychiatry and could be equally useful for other medical conditions. Leading clinical researchers studying a given disorder complete a survey soliciting their opinions on its most important disease management questions that are not covered well by definitive research. The survey response rates among the experts for the four different psychiatric disorders have each exceeded 85%. The views of the clinical researchers are validated by surveying separately a large group of practicing clinicians to ensure that the guideline recommendations are widely generalizable. All of the suggestions made in the guideline are derived from, and referenced to, the experts' survey responses using criteria that were established a priori for defining first-, second-, and third-line choices. Analysis of survey results suggests that this method of quantifying expert responses achieves a high level of reliability and reproducibility. This survey method is probably the best available means for standardizing practice for decisions points not well covered by research.  (+info)

Proteostasis deficiencies can result from genetic mutations, environmental factors, or a combination of both. These deficiencies can affect different cellular components, such as mitochondria, endoplasmic reticulum (ER), and proteasomes, leading to the accumulation of misfolded proteins in various compartments of the cell.

Some examples of diseases caused by proteostasis deficiencies include:

1. Neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, and Huntington's disease, which are characterized by the accumulation of misfolded proteins in the brain.
2. Aggregation disorders such as amyloidosis, where misfolded proteins form insoluble fibrils that deposit in tissues and organs.
3. Cancer, where mutations in genes involved in protein synthesis and degradation can lead to the accumulation of oncogenic proteins or the loss of tumor suppressor proteins.
4. Metabolic disorders such as type 2 diabetes, which is associated with the misfolding of proteins involved in insulin signaling.
5. Mitochondrial diseases, where mutations in mitochondrial DNA can lead to the accumulation of misfolded proteins in the mitochondria.

Overall, proteostasis deficiencies can have a significant impact on cellular function and can lead to a wide range of diseases. Understanding the mechanisms of protein homeostasis and identifying therapeutic strategies to correct or compensate for proteostasis deficiencies are critical for the development of effective treatments for these diseases.

Neoplasm refers to an abnormal growth of cells that can be benign (non-cancerous) or malignant (cancerous). Neoplasms can occur in any part of the body and can affect various organs and tissues. The term "neoplasm" is often used interchangeably with "tumor," but while all tumors are neoplasms, not all neoplasms are tumors.

Types of Neoplasms

There are many different types of neoplasms, including:

1. Carcinomas: These are malignant tumors that arise in the epithelial cells lining organs and glands. Examples include breast cancer, lung cancer, and colon cancer.
2. Sarcomas: These are malignant tumors that arise in connective tissue, such as bone, cartilage, and fat. Examples include osteosarcoma (bone cancer) and soft tissue sarcoma.
3. Lymphomas: These are cancers of the immune system, specifically affecting the lymph nodes and other lymphoid tissues. Examples include Hodgkin lymphoma and non-Hodgkin lymphoma.
4. Leukemias: These are cancers of the blood and bone marrow that affect the white blood cells. Examples include acute myeloid leukemia (AML) and chronic lymphocytic leukemia (CLL).
5. Melanomas: These are malignant tumors that arise in the pigment-producing cells called melanocytes. Examples include skin melanoma and eye melanoma.

Causes and Risk Factors of Neoplasms

The exact causes of neoplasms are not fully understood, but there are several known risk factors that can increase the likelihood of developing a neoplasm. These include:

1. Genetic predisposition: Some people may be born with genetic mutations that increase their risk of developing certain types of neoplasms.
2. Environmental factors: Exposure to certain environmental toxins, such as radiation and certain chemicals, can increase the risk of developing a neoplasm.
3. Infection: Some neoplasms are caused by viruses or bacteria. For example, human papillomavirus (HPV) is a common cause of cervical cancer.
4. Lifestyle factors: Factors such as smoking, excessive alcohol consumption, and a poor diet can increase the risk of developing certain types of neoplasms.
5. Family history: A person's risk of developing a neoplasm may be higher if they have a family history of the condition.

Signs and Symptoms of Neoplasms

The signs and symptoms of neoplasms can vary depending on the type of cancer and where it is located in the body. Some common signs and symptoms include:

1. Unusual lumps or swelling
2. Pain
3. Fatigue
4. Weight loss
5. Change in bowel or bladder habits
6. Unexplained bleeding
7. Coughing up blood
8. Hoarseness or a persistent cough
9. Changes in appetite or digestion
10. Skin changes, such as a new mole or a change in the size or color of an existing mole.

Diagnosis and Treatment of Neoplasms

The diagnosis of a neoplasm usually involves a combination of physical examination, imaging tests (such as X-rays, CT scans, or MRI scans), and biopsy. A biopsy involves removing a small sample of tissue from the suspected tumor and examining it under a microscope for cancer cells.

The treatment of neoplasms depends on the type, size, location, and stage of the cancer, as well as the patient's overall health. Some common treatments include:

1. Surgery: Removing the tumor and surrounding tissue can be an effective way to treat many types of cancer.
2. Chemotherapy: Using drugs to kill cancer cells can be effective for some types of cancer, especially if the cancer has spread to other parts of the body.
3. Radiation therapy: Using high-energy radiation to kill cancer cells can be effective for some types of cancer, especially if the cancer is located in a specific area of the body.
4. Immunotherapy: Boosting the body's immune system to fight cancer can be an effective treatment for some types of cancer.
5. Targeted therapy: Using drugs or other substances to target specific molecules on cancer cells can be an effective treatment for some types of cancer.

Prevention of Neoplasms

While it is not always possible to prevent neoplasms, there are several steps that can reduce the risk of developing cancer. These include:

1. Avoiding exposure to known carcinogens (such as tobacco smoke and radiation)
2. Maintaining a healthy diet and lifestyle
3. Getting regular exercise
4. Not smoking or using tobacco products
5. Limiting alcohol consumption
6. Getting vaccinated against certain viruses that are associated with cancer (such as human papillomavirus, or HPV)
7. Participating in screening programs for early detection of cancer (such as mammograms for breast cancer and colonoscopies for colon cancer)
8. Avoiding excessive exposure to sunlight and using protective measures such as sunscreen and hats to prevent skin cancer.

It's important to note that not all cancers can be prevented, and some may be caused by factors that are not yet understood or cannot be controlled. However, by taking these steps, individuals can reduce their risk of developing cancer and improve their overall health and well-being.

Some common examples of neurodegenerative diseases include:

1. Alzheimer's disease: A progressive loss of cognitive function, memory, and thinking skills that is the most common form of dementia.
2. Parkinson's disease: A disorder that affects movement, balance, and coordination, causing tremors, rigidity, and difficulty with walking.
3. Huntington's disease: An inherited condition that causes progressive loss of cognitive, motor, and psychiatric functions.
4. Amyotrophic lateral sclerosis (ALS): A disease that affects the nerve cells responsible for controlling voluntary muscle movement, leading to muscle weakness, paralysis, and eventually death.
5. Prion diseases: A group of rare and fatal disorders caused by misfolded proteins in the brain, leading to neurodegeneration and death.
6. Creutzfeldt-Jakob disease: A rare, degenerative, and fatal brain disorder caused by an abnormal form of a protein called a prion.
7. Frontotemporal dementia: A group of diseases that affect the front and temporal lobes of the brain, leading to changes in personality, behavior, and language.

Neurodegenerative diseases can be caused by a variety of factors, including genetics, age, lifestyle, and environmental factors. They are typically diagnosed through a combination of medical history, physical examination, laboratory tests, and imaging studies. Treatment options for neurodegenerative diseases vary depending on the specific condition and its underlying causes, but may include medications, therapy, and lifestyle changes.

Preventing or slowing the progression of neurodegenerative diseases is a major focus of current research, with various potential therapeutic strategies being explored, such as:

1. Stem cell therapies: Using stem cells to replace damaged neurons and restore brain function.
2. Gene therapies: Replacing or editing genes that are linked to neurodegenerative diseases.
3. Small molecule therapies: Developing small molecules that can slow or prevent the progression of neurodegenerative diseases.
4. Immunotherapies: Harnessing the immune system to combat neurodegenerative diseases.
5. Lifestyle interventions: Promoting healthy lifestyle choices, such as regular exercise and a balanced diet, to reduce the risk of developing neurodegenerative diseases.

In conclusion, neurodegenerative diseases are a complex and diverse group of disorders that can have a profound impact on individuals and society. While there is currently no cure for these conditions, research is providing new insights into their causes and potential treatments. By continuing to invest in research and developing innovative therapeutic strategies, we can work towards improving the lives of those affected by neurodegenerative diseases and ultimately finding a cure.

1. Insomnia: difficulty falling asleep or staying asleep
2. Sleep apnea: pauses in breathing during sleep
3. Narcolepsy: excessive daytime sleepiness and sudden attacks of sleep
4. Restless leg syndrome: uncomfortable sensations in the legs during sleep
5. Periodic limb movement disorder: involuntary movements of the legs or arms during sleep
6. Sleepwalking: walking or performing other activities during sleep
7. Sleep terrors: intense fear or anxiety during sleep
8. Sleep paralysis: temporary inability to move or speak during sleep
9. REM sleep behavior disorder: acting out dreams during sleep
10. Circadian rhythm disorders: disruptions to the body's internal clock, leading to irregular sleep patterns.

Sleep disorders can be caused by a variety of factors, such as stress, anxiety, certain medications, sleep deprivation, and underlying medical conditions like chronic pain or sleep apnea. Treatment for sleep disorders may include lifestyle changes (such as establishing a regular sleep schedule, avoiding caffeine and alcohol before bedtime, and creating a relaxing sleep environment), medications, and behavioral therapies (such as cognitive-behavioral therapy for insomnia). In some cases, surgery or other medical interventions may be necessary.

It is important to seek medical attention if you suspect that you or someone you know may have a sleep disorder, as untreated sleep disorders can lead to serious health problems, such as cardiovascular disease, obesity, and depression. A healthcare professional can help diagnose the specific sleep disorder and develop an appropriate treatment plan.

A control chart is a more specific kind of run chart. The control chart is one of the seven basic tools of quality control, ... Interpretation of quality control data involves both graphical and statistical methods. Quality control data is most easily ... Quality control Quality assurance Quality assessment Tietz, N.W. (1987). "Fundamentals of Clinical Chemistry", Third Edition, W ... Westgard, J. O., P. L. Barry (1986). "Cost-Effective Quality Control: Managing the Quality and Productivity of Analytical ...
Quality control may also refer to: Analytical quality control Quality Control (album), a 2000 album by Jurassic 5 "Quality ... Control", title track from the above Quality Control Music, an American record label Quality Control: Control the Streets ... Look up quality control in Wiktionary, the free dictionary. Quality control is a process for maintaining proper standards in ... a compilation album by Quality Control Music A song from Summer Girl, the fifth LP from Smash Mouth This disambiguation page ...
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The term was introduced in this context by W. Edwards Deming, and he was a strong proponent of using control charts to avoid ... Incentive program Control chart W. Edwards Deming (1994) The New Economics for Industry, Government, Education, 2nd edition, ... Tampering in the context of a controlled process is adjusting the process on the basis of outcomes which are within the ... Quality control, All stub articles, Statistics stubs). ... Tools and Methods for The Improvement of Quality, CRC Press ...
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Thus, there is no standard set of tests for the quality control of TEMPs. The EMA has released a set of regulatory guidelines ... Proper quality control involves the release testing of the final product through updated and validated methods. The release ... Quality control and assurance are of paramount importance and products are constantly assessed throughout the manufacturing ... However, in these cases adequate quality control has to rise from the manufacturing process. Specifications about the stability ...
"Colorado Water Quality Control Division - Sanitary Survey Program". Retrieved 21 February 2013. "Colorado Water Quality Control ... The Colorado Water Quality Control Division focuses on water quality for the State of Colorado. Its objective is to protect and ... Inspections are carried out by the Water Quality Control Division, which focuses on ensuring the quality of public water ... "Colorado Water Quality Control Division - Water Assessment Program". Retrieved 21 February 2013. "Colorado Water Quality ...
... after the Promulgation of the Pakistan Standards Quality Control Authority and was renamed as Quality Control Centre. In 2014, ... The Quality Control Centre (QCC) is a multifunctional testing laboratory which test quality of food, building materials (cement ... The Pakistan Standards & Quality Control Authority (PSQCA) (Urdu: مختاریہَ پاکستان برائے انضباطِ کیفیات و معیارات) is an ... The PSQCA was formed through the passage of the Pakistan Standards and Quality Control Authority Act, 1996 by the Parliament of ...
Quality control can help spot which meteorological observations are inaccurate. One of the main automated quality control ... Another basic quality control check is to have the data compared to preset geographic extremes, perhaps combined with diurnal ... Systems such as MADIS use a three-pronged approach to quality control. This approach is much better mainly because it has more ... The level two statistical spatial test tests whether or not the station has failed any quality control check more than 75% of ...
The Lower Molonglo Water Quality Control Centre is a sewerage and waste water treatment facility in the Australian Capital ... The Lower Molonglo Water Quality Control Centre (or LMWQCC) is the largest inland treatment facility in Australia[citation ... www.iconwater.com.au/water-and-sewerage-system/water-and-sewerage-system/sewage-treatment/lower-molonglo-water-quality-control- ... "Lower Molonglo Water Quality Control Centre - 1978-". Engineers Australia. Retrieved 3 May 2020. http:// ...
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Quality Control Systems Education Common Interest Group of the Process Control Division (2012). Paper Machine Quality Control ... A quality control system (QCS) refers to a system used to measure and control the quality of moving sheet processes on-line as ... Distributed Control System PLC Safety instrumented system, (SIS) Industrial control systems Quality Control Systems Education ... These measurement values from a single scan (profile points) are called 'raw profiles'. In modern quality control systems, the ...
... also often gets mixed-up with Quality Assurance or Problem Resolution Management or Quality Control or DevOps ... A. V. Feigenbaum, "Total Quality Control", McGraw-Hill, 1983. J.M. Juran, "Juran's Quality Control Handbook", McGraw-Hill, 1988 ... ISO/IEC 15504 Programming style Quality: quality control, total quality management. Requirements management Scope (project ... Hoipt (2019-11-29). "Organizations often use the terms 'Quality Assurance' (QA) vs 'Quality Control' (QC)…". Medium. Retrieved ...
Process quality: Quality engineers may be tasked with value stream mapping and statistical process control to determine if a ... Quality objectives describe basic requirements for software quality. In quality engineering they often address the quality ... Quality Engineers focus on optimizing product quality which W. Edwards Deming defined as: Quality = Results of work efforts ... verification Reliability and maintainability Product and process control Continuous improvement Quality control tools Quality ...
Quality audit Armand Vallin Feigenbaum. Total quality control: engineering and management McGraw-Hill, 1951 pg. 542 (Quality ... Besides checking good quality of the unit, this process also must ensure that none of the configuration will be touched. There ... The final quality audit (FQA) process, in the electronic hardware manufacturing world, is the last process flow before shipping ... is established to ensure the unit has gone through and passed all the manufacturing or test process and is in good quality. ...
At that time, companies that had set about training their workforces in statistical quality control found that the complexity ... As a result, people either feared or disliked quality control as something very difficult. We overeducated people by giving ... ISBN 978-0-394-55186-9. Ishikawa, Kaoru (1985). What Is Total Quality Control? The Japanese Way. Translated by Lu, David J. ( ... ISBN 978-0-13-952433-2. --- (1990). Introduction to Quality Control (1st ed.). Tokyo: 3A Corp. ISBN 978-4-906224-61-6. ...
2007). "Chapter 22 B. Material Control". The Certified Quality Engineer Handbook. ASQ Quality Press. pp. 183-189. ISBN ... Mitra, A. (2016). "Chapter 8: Control Charts for Attributes". Fundamentals of Quality Control and Improvement. John Wiley & ... When ensuring quality of a product or a service, classification of a nonconformity is important, as it provides an opportunity ... In quality management, a nonconformity (sometimes referred to as a non conformance or nonconformance or defect) is a deviation ...
Quality control. Accuracy of transcription and aptness of markup are assessed in all cases by a group of library-based proofers ... representative quality, avoidance of duplication; specific requests from faculty or scholarly initiatives at member ...
... a clear distinction between a positive control and a negative reference such as a negative control is an index for good quality ... Many quality-assessment measures have been proposed to measure the degree of differentiation between a positive control and a ... Zhang, XHD (2007). "A pair of new statistical parameters for quality control in RNA interference high-throughput screening ... Zhang XHD (2008). "Novel analytic criteria and effective plate designs for quality control in genome-scale RNAi screens". ...
"Quality Control". The Washington Post. November 14, 2014. Retrieved January 31, 2015. Crabs, The New Yorker Poto Mitan - Writer ... However, while the women of Breath, Eyes, Memory replicate "state-sanctioned" control and violation of women's bodies through ...
"Quality Control". Music Technology. No. 83. September 1993. p. 53. ISSN 0957-6606. OCLC 24835173. Korg official site Portals: ...
... quality control; improved health of the local population and public image; and realisation of potential income through the sale ...
Richard Wilson (13 April 2011). "Quality control". The Herald. Glasgow. Retrieved 4 March 2012. "Leading Scots lawyer Paul ...
"Quality Control". CityBeat Cincinnati. Retrieved August 6, 2018. "Newtown's new sweet spot: Doscher's Candies". Cincinnati.com ...
Quality Control. Manufacturing Chemist. October 2016. "Morphologically Directed Raman Spectroscopic Analysis of Forensic ... "Controlled Vapor Phase Growth of Single Crystalline, Two-Dimensional Ga Se Crystals with High Photoresponse". Scientific ... to separate the Raman scattered light from the Rayleigh signal and reflected laser signal in order to collect high quality ...
... quality control; piracy tracking and distribution. The content is then made available in PixelMags' "Newsstands" for paid ...
After the Central Valley Project Improvement Act in 1991 and the Bay-Delta Water Quality Control Plan in 1995, much more water ... Draft Revised Substitute Environmental Document in Support of Potential Changes to the Water Quality Control Plan for the Bay- ... Draft Revised Substitute Environmental Document in Support of Potential Changes to the Water Quality Control Plan for the Bay- ... Delta: San Joaquin River flows and Southern Delta water quality. California State Water Resources Control Board. September 2016 ...
Raw pu'er tea can be aged up to 50 years in some cases without diminishing in quality, and ripened pu'er can be aged up to 10 ... This ripening is done through a controlled process similar to composting, where the moisture and temperature of the tea are ... The fermentation of tea leaves alters their chemistry, affecting the organoleptic qualities of the tea made from them. ...
Pecan oil - valued as a food oil, but requiring fresh pecans for good quality oil. Pectin - vegetable gum, emulsifier Perilla ... Acidity regulators Acidity regulators are used to change or otherwise control the acidity and alkalinity of foods. Anticaking ... Food additives are substances added to food to preserve flavor or enhance its taste, appearance, or other qualities. Additives ... Heliotropin - Helium - propellant Hemlock oil - Hemp oil - a high quality food oil. Heptyl p-hydroxybenzoate - preservative ...
Dieter Grau, 101, German-born American rocket scientist, NASA Quality Control Director for the Saturn V. Neil James, 53, ...
In the first race at Phillip Island, he was hit by an out-of-control Alex Premat at turn 4, but was only spun, suffering ... The combination of Reynolds, engineer Alistair McVean, and a brand new car with quality componentry developed by Erebus ...
These unanimously judged the quality and originality of the work positively; many pieces were judged to be of museum quality. ... Articles with suppressed authority control identifiers, ACArt with 2 suppressed elements, 1913 births, 1983 deaths, 20th- ...
Before 1985, the government of Taiwan maintained strict controls on private universities and, in particular, discouraged ... many of very marginal quality). In 2010 it was announced that HCU passed the re-evaluation (though several departments were ...
... has, in general, been used for decades to monitor material quality based on particle size. For coarse material, ... Amplitude and sieving time are set digitally and are continuously observed by an integrated control-unit. Therefore, sieving ...
Moreover, it exhibits a significant control on the transport of pollutants across the river basin. The main factors affecting ... the hyporheic zone can be designed by engineers and actively managed for improvements in both water quality and riparian ... Control on the water and solute exchange between the main stream and the groundwater; Mitigation of river water temperature. A ... "Geomorphic controls on hyporheic exchange flow in mountain streams". Water Resources Research. 39 (1): SBH 3-1-SBH 3-14. ...
On the other hand, researchers might also face difficulty in assessing the quality of statistics based on MPD because the ... it is critical to model and quantify human mobility in order to improve epidemic control. Examples: analysing Malaria ... For statistical purposes, mobile positioning data provides new possibilities in terms of the quality of the data. Statistics ... but the new concept of fast and expansive data collection improves the quality of decision-making processes and results in ...
It has traditionally been controlled by Labour or the Conservatives. The council is currently in a state of no overall control ... The Civic Centre municipal office building in Armada Way became a listed building in June 2007 because of its quality and ... This campaign was unsuccessful, and on 1 April 1974, Plymouth surrendered control of several areas to Devon County Council. ...
The Network Control Protocol (NCP) for the ARPANET was first implemented in 1970. The designers of the NCP envisioned a ... Gateways are well known to be a cause of loss of quality and frustration. Allowing IP to penetrate may well upset the ... "NCP - Network Control Program", Living Internet Cerf, V.; Kahn, R. (1974). "A Protocol for Packet Network Intercommunication" ( ... In version 3 of TCP, written in 1978, the Transmission Control Program was split into two distinct protocols, the Internet ...
She said I think they bring out some nice qualities in each other - Roxy brings out the fun side of Kyle, but they can also be ... Anderson explained that Roxy cannot control her happiness upon seeing Mark and launches herself at him "like a ball of love", ...
The three-axis control system is unconventional, with pitch controlled by an all-flying canard, yaw by wingtip rudders and roll ... The US National Transportation Safety Board cited the probable causes as improper maintenance and quality assurance on the part ...
Fields, Scott (2004). "Global Nitrogen: Cycling out of Control". Environmental Health Perspectives. 112 (10): A556-A563. doi: ... affect water quality, and endanger downstream fish populations. Pools formed by the dams store heat, thus changing local ... Wetland benefits include flood control downstream, biodiversity (by providing habitat for different species), and water ... Journal of Environmental Quality. 44 (5): 1684-1693. doi:10.2134/jeq2014.12.0540. PMID 26436285. Grannes, S.G. (2008). "Beaver ...
The Symbolics keyboard featured the many modifier keys used in Zmacs, notably Control/Meta/Super/Hyper in a block, but did not ... Symbolics developed the first workstations able to process high-definition television (HDTV) quality video, which enjoyed a ... The 3600 architecture provided 4,096 hardware registers, of which half were used as a cache for the top of the control stack; ... Symbolics felt that they no longer had sufficient control over their product. At that point, Symbolics began using their own ...
... which had recently changed from Republican control to Democratic Party control, voted to abolish the eight-year old Arizona ... Cool Qualities, and Remarkable Abilities of Women and Girls (Houghton Mifflin Harcourt, 2003), pp48-49 "Roosevelt Visits ...
Spain regained control of the Florida Provinces (las Floridas) after the Siege of Pensacola and the Treaty of Paris following ... ranked Florida's state flag 34th in design quality of the 72 Canadian provincial, U.S. state and U.S. territorial flags ranked ... It also used this flag when Floridian forces took control of U.S. forts and a Navy yard in Pensacola. Col. William H. Chase was ... In 1763, Spain passed control of Florida to Great Britain via the Treaty of Paris, following the latter's victory over France ...
The Assyrians lived largely in peace under the rule of the Ottoman Empire, which gained control of Assyria in 16th century. In ... "epic quality" unlike the art under his predecessors. Statue of a praying woman, 25th century BC Wall relief probably depicting ... Under the Seleucid Empire, which controlled Mesopotamia from the late 4th to mid-2nd century BC, Assyrian sites such as Assur, ... native Assyrians and Hurrians for control. The infighting came to an end after the rise of Bel-bani as king c. 1700 BC. Bel- ...
Because of the increasing automation of farming (large equipment, GPS-controlled seeding, spraying, etc.), farming operations ... they can make or afford higher-quality equipment than if they were working alone.[citation needed] Some also run industrial hog ...
The presence of street vendors in Mexico City dates to the pre-Hispanic era and the government has struggled to control it, ... Law enforcement often enters into conflict - sometimes physical - with camelôs, for selling low-quality products (often ... "merchant of low-quality goods," and the term marreteiro is also sometimes used. The difference between camelôs and so-called " ... Many people who work as camelôs sell their products knowing that they are of low quality, and charge high prices nonetheless.[ ...
Some engine controls shut down an engine or limit it to half throttle if it overheats. Modern electronic engine controls adjust ... But as air quality awareness rose in the 1960s, and laws governing exhaust emissions were passed, unleaded gas replaced leaded ...
Historically, the elephants were under the constant control of a driver or mahout, thus enabling a ruler to grant a last-minute ... reprieve and display merciful qualities. Several such exercises of mercy are recorded in various Asian kingdoms. The kings of ... the elephants were used to signify both the ruler's power of life and death over his subjects and his ability to control wild ...
After controlling for stage, there still existed differences in survival rates. "CERVICAL , meaning in the Cambridge English ... Muliira RS, Salas AS, O'Brien B (2016). "Quality of Life among Female Cancer Survivors in Africa: An Integrative Literature ... Other risk factors include smoking, a weak immune system, birth control pills, starting sex at a young age, and having many ... Tran NP, Hung CF, Roden R, Wu TC (2014). Control of HPV infection and related cancer through vaccination. Recent Results in ...
However, even though Hong Kong is under control of the People's Republic of China, DVDs found here are not Region 6 (for users ... Although the UK uses the higher-quality RGB signal transmission scheme provided by European Standard SCART, SCART ports are ...
Whereas congestion control prevents senders from overwhelming the network, flow control prevents the sender from overwhelming ... Network congestion in data networking and queueing theory is the reduced quality of service that occurs when a network node or ... Congestion control then becomes a distributed optimization algorithm. Many current congestion control algorithms can be ... Nanda, Priyadarsi (2000-11-01). "A Control Theory Approach for Congestion Control in Intranetwork". IFAC Proceedings Volumes. ...
According to HR, one's ability to control one's thoughts is limited and the effort to do so can itself be a source of stress. ... that the quality of one's thinking is exactly as it needs to be. HR holds that the therapeutic "working through" of personal ... ISBN 1-55105-556-2, ISBN 978-1-55105-556-5 T.M.Kelley, A critique of social bonding and control theory of delinquency using the ... Many case examples and a modest body of controlled outcome research in solution focused brief therapy (SFBT), have likewise ...
Robin and the latter eventually assault her base and defeat her, freeing the city from her control. The H.I.V.E. Queen returns ... Quality Comics. Justice League Adventures #6 Justice League Unlimited #29 Flashpoint: The Canterbury Cricket one-shot (June ... She reappears much later in Teen Titans, where she takes control of the entire city of New Orleans. She then has the mind- ... She has been described as a "world-class telepath" by Robin and has proven capable of controlling thousands of people at once ...
A variation on this is the "booty tag" mode, in which there is a single chest and the teams fight for control of the chest to ... The game has been received positively by the industry's critics, being praised for its originality and graphical quality. By ... The third game mode is "territory", in which teams fight for control of a strategic area of their surroundings. When one team ...
reported using tomographic methods to track the passage of cosmic rays muons through cesium iodide crystals for quality control ... The Technical Basis for Arms Control, Disarmament, and Nonproliferation Initiatives. Taylor & Francis. 16 (1-2): 37-53. Bibcode ...
Field Testing of Mixed Reality (MR) Technologies for Quality Control of As-Built Models at Project Handover: A Case Study ... Real-Time Quality Control and Infilling of Precipitation Data Using Neural Networks ... A New Tool for Automated Quality Control of Environmental Data in Open Web Services ... Automated Image Quality Evaluation of Structural Brain Magnetic Resonance Images using Deep Convolutional Neural Networks ...
CLIA Individualized Quality Control Plan Introductionpdf iconexternal icon. *CLIA IQCP, Considerations When Deciding to Develop ... A QC option is now available that provides laboratories the opportunity to tailor an individualized quality control plan (IQCP ... The Clinical Laboratory Improvement Amendments of 1988 (CLIA) regulations require a laboratory to have quality control (QC) ... Centers for Disease Control and Prevention. CDC twenty four seven. Saving Lives, Protecting People ...
... [Abstract IRGM1 Links Mitochondrial Quality Control to Autoimmunity ... Synopsis IRGM1 Links Mitochondrial Quality Control to Autoimmunity] [Story IRGM1 Links Mitochondrial Quality Control to ... Use the browser controls to adjust the font size, or print this page. ...
... Keyboard controls: Space bar - toggle play/pause; ... ClinicalTrials.gov Webinar: Updated Quality Control and Posting Procedures (43:29). Rebecca Williams, PharmD, MPH, Acting ... regardless of whether the quality control (QC) review process is complete.. This presentation describes the updated procedures ...
... assures the quality of your processes, products, machinery, equipment, systems and coatings - anywhere in the world. Discover ... Quality Control. Quality control from SGS - assures the quality of your processes, products, machinery, equipment, systems and ... As a highly qualified, independent third-party, we have the trusted skills and resources to perform quality control. As the ... We provide comprehensive quality control and certification to ensure compliance with all specified requirements. ...
Good Practices, Lessons Learned, Quality, Quality Assurance, Quality Control, Nuclear Facilities, Management Systems, Nuclear ... Quality Assurance and Quality Control in Nuclear Facilities and Activities. ×. If you would like to learn more about the IAEAs ... The publication discusses the elements of a management system relevant for the quality assurance and quality control functions ... This publication explains the concepts of quality assurance and quality control. It provides examples, illustrated by good ...
ClinicalTrials.gov: Updated Quality Control and Posting Procedures. ClinicalTrials.gov: Updated Quality Control and Posting ... regardless of whether the quality control (QC) review process has been completed. ...
USGS Earthquake Hazards Program, responsible for monitoring, reporting, and researching earthquakes and earthquake hazards
Download a complimentary chapter of Information Quality: The Potential of Data and Analytics to Generate Knowledge. ... Qualified instructors from the US, Canada and Europe can now request a free copy of Introduction to Statistical Quality Control ... Check out how companies and universities are using JMP for quality control and monitoring:. California Polytechnic State ... JMP is also an effective tool for teaching statistical quality control (SQC) methods and concepts.. ...
GUE takes matters of quality control very seriously. To bring issues to our attention, and to ensure prompt and confidential ...
Addresses of drug quality control laboratories or centres  World Health Organization. Quality Assurance and Safety (‎World ...
, International trade fair for quality assurance
The GCBC will evaluate the quantity and quality of investigator-supplied DNA or RNA, then prepare libraries for short- or long ...
Shop Inorganic Ventures Quality Control Standard 28 at Thomas Scientific, your trusted partner in Science. ... Quality Control Standard 28. * PRODUCT AVAILABILITY: Did you know you can view a products availability right on the product ... Inorganic Ventures Quality Control Standard 28 is a 125 mL certified reference material set in a nitric acid (tr. hydrofluoric ... This standard is Traceable to NIST and manufactured in accordance with our stringent Quality Assurance guidelines. One year ...
Join this webinar to learn about harmonizing quality and manufacturing excellence through digitization, and to support a Pharma ... The Benefits of Digital Pathology with Automated Quality Control for Accelerating Drug Discovery. February 15, 2023 ... The Quality Culture Playbook: How to Build a Quality Culture. August 18, 2021 ... R&D Quality as the Foundation for Product Quality. June 01, 2020 ... We do not control these third-party websites and are not ...
The Buzz: How the GOP gained control of air… Share this:. *Click to share on Facebook (Opens in new window) ... While the air quality board and city councils are non-partisan, Whitaker and state GOP Chairman Jim Brulte are working to build ... Santa Ana Mayor Miguel Pulido, a Democrat, is being ousted by Republicans from his post on the regional air quality board. ... Lake Forest Councilman Dwight Robinson will be Orange County cities next representative on the regional air quality board, ...
Control, is soliciting proposals for an HPV Quality Control (QC) Group that will be responsible for overseeing all aspects of ... HPV QUALITY CONTROL GROUP FOR THE ASCUS/LSIL CLINICAL MANAGEMENTTRIAL NIH GUIDE, Volume 23, Number 40, November 18, 1994 RFP ... quality control experiments and the performance of repeat "in-house testing of specimens; (4) ongoing participation in the ... Management and Quality Assurance systems. INQUIRIES Requests for this solicitation must be in writing and reference the RFP ...
... quality out. That's the basic mantra of DNA sequencing. ... DNA Sequencing Quality Controls. Quality in, quality out. ... The quality of your DNA sample before sequencing is directly correlated with the accuracy of your sequencing results. Learn ... more about ensuring quality throughout your sequencing workflow in this short video from Advanced Analytical. www.aati.us.com ...
Quality control requirements are fully documented and controlled: This ensures a comprehensive assessment of production from ... Quality that Lasts. Our products undergo extensive testing that exceeds the industrys most rigid quality expectations. Insight ... What does this mean? You have a quality product that has been thoroughly tested thru all aspects of its function. In the case ... Furthermore, our USA and China facilitys ISO 13485:2016 certification points to a robust quality management system overseeing ...
California water quality and rights regulation, board meetings, laws, funding, watershed management, enforcement, citizen ... The State Water Resources Control Board web site covers ... Welcome to the California Regional Water Quality Control Board ... Nirmal Sandhar, Division of Water Quality, or phone (916) 341-5571 or. Stacy E. Gillespie, Senior Staff Counsel, or phone (916 ... The California Water Boards include the State Water Resources Control Board and nine Regional Boards. The State Water Board is ...
... on the thermoIMAGER series of thermal imaging cameras from Micro-Epsilon in its inline inspection machines for quality control ... Thermal imaging cameras inspect the surfaces of materials and workpieces, enabling the quality of components to be assessed. ... that workpieces can be automatically checked for various geometrical features or conclusions can be drawn about their quality. ...
Quality Control Log Sheet Quick Guide, from CLSI. Find this and other point-of-care testing standards documents in the CLSI ... POCT08 , Quality Practices in Noninstrumented Point-of-Care Testing: An Instructional Manual and Resources for Health Care ...
OCALA OPS QUALITY CONTROL ANALYST - 65650325(Staff Assistant) - FL, 34470 ...
The proof-of-principle study helps pave the way for AI-based quality control of therapeutic cells and tissues. The method was ... NIH, NIST researchers use artificial intelligence for quality control of stem cell-derived tissues ... NIH, NIST researchers use artificial intelligence for quality control of stem cell-derived tissues ... reproducible measurement of tissue quality," Simon said. ...
Home ›ComplianceOnline Standards ›Quality Management › AS9003 Starter Kit for Inspection and Test Quality Control System ... AS9003 Comprehensive Quality System Kit for Inspection and Test Quality Control System ... Quality Control Laboratory Compliance - cGMPs and GLPs: One and a Half Day Virtual Seminar. ...
... reliable and inexpensive metrology tool used in the quality control process of production. Patented for manufacturing in 1943, ... Test & InspectionQuality 101AutomotiveAerospace Quality 101. Air Gages: Accurate, Easy and Efficient Quality Control. Air gages ... Quality Automation: The Role Robotics and Sensors Play in Quality Control and Production ... The Quality Show The Quality Show is a 3-day tradeshow dedicated to connecting quality manufacturing professionals with process ...
Learn how to meet the expectations of your client by using construction quality control to plan, identify and resolve issues. ... and quality control (QC). Quality assurance sets the quality management expectations and how quality will be achieved. Quality ... Quality Control Procedures in the Construction Industry. When working on construction quality control, there need to be quality ... Quality Control Manager: Choose someone to lead the effort-a quality control manager. The client needs to know who this person ...
... the quality of wine products is poorly controlled. As a rule, wine producers must verify their own product quality and take ... To control the origin and quality of wine, particularly wine processed by households, the Government issued a decree on wine ... The rest is produced by households, out of the oversight of any quality control authority. ... "The local authorities are not in charge of wine quality so we can only remind the families to protect their traditional wine ...
Poster presentation: An automated system for clinical laboratory quality control review and management of assay performance ... An Automated System for Clinical Laboratory Quality Control Review and Management of Assay Performance ... An Automated System for Clinical Laboratory Quality Control Review and Management of Assay Performance ... Delivering sustainable change in quality and outcomes We work with ACOs to achieve better care for patients and better health ...
  • This publication explains the concepts of quality assurance and quality control. (iaea.org)
  • The publication discusses the elements of a management system relevant for the quality assurance and quality control functions, such as the generation and retention of documented information. (iaea.org)
  • The information presented will help in ensuring the safe and economic operation of nuclear facilities and provide a neutral technical basis for dialogue between government bodies, regulators, plant operators and suppliers when dealing with management system, quality assurance and quality control issues. (iaea.org)
  • This standard is Traceable to NIST and manufactured in accordance with our stringent Quality Assurance guidelines. (thomassci.com)
  • and (6) establishment of Data Management and Quality Assurance systems. (nih.gov)
  • The measurements go to the Perform Quality Assurance process. (dummies.com)
  • By incorporating these tools into an overall quality assurance program, a laboratory can identify systematic errors and perform corrective actions before actual assay failure, thereby improving the quality of patient care. (nih.gov)
  • The purpose of these Guidelines is to assist investigators in developing and implementing quality assurance (QA) procedures that can be integrated into their clinical research projects. (nih.gov)
  • ClinicalTrials.gov: Updated Quality Control and Posting Procedures. (nih.gov)
  • JMP is also an effective tool for teaching statistical quality control (SQC) methods and concepts. (jmp.com)
  • Qualified instructors from the US, Canada and Europe can now request a free copy of Introduction to Statistical Quality Control: A JMP Companion by Brenda and José Ramírez . (jmp.com)
  • Records test data, applying statistical quality control procedures. (spherion.com)
  • As the leading provider of inspection, verification, certification and testing, we are the first choice for clients looking to assure quality across the world. (sgs.com)
  • Selects products for tests at specified stages in production process (including incoming inspection), and tests products for a variety of qualities such as visual, dimensional, performance, and mechanical characteristics. (spherion.com)
  • The »imess« company relies on the thermoIMAGER series of thermal imaging cameras from Micro-Epsilon in its inline inspection machines for quality control and dimensional accuracy testing. (micro-epsilon.com)
  • FDA inspection processes and other quality aspects associated with the manufacture of Biopharmaceuticals. (kgi.edu)
  • Quality metrics files are provided for all steps in the process. (nih.gov)
  • Quality control (QC) metrics are critical in high-throughput screening (HTS) platforms to ensure reliability and confidence in assay data and downstream analyses. (nih.gov)
  • With the advent of high-throughput combination screening, there is a need for QC metrics that quantify the quality of combination response matrices. (nih.gov)
  • We provide comprehensive quality control and certification to ensure compliance with all specified requirements. (sgs.com)
  • A concerted, back-channels effort by Republican leaders has succeeded in gaining a board majority at the South Coast Air Quality Management District, which oversee the regulation and compliance of everything from power plants to gas stations. (ocregister.com)
  • This course will provide an introduction to the concepts and requirements for global pharmaceutical quality compliance. (kgi.edu)
  • The Clinical Laboratory Improvement Amendments of 1988 (CLIA) regulations require a laboratory to have quality control (QC) procedures to monitor the accuracy and precision of the complete testing process. (cdc.gov)
  • Consistent with 42 CFR Part 11, the updated procedures allow NLM to publicly post submitted results information within 30 days of submission, regardless of whether the quality control (QC) review process has been completed. (nih.gov)
  • The Guidelines specify the procedures investigators should develop and implement to prevent , to detect , and to correct data quality and integrity problems. (nih.gov)
  • As a result, we can provide trained and qualified technical specialists to control the quality of your processes, products, machinery, equipment, systems and coatings in every corner of the world - fast. (sgs.com)
  • Identifies ways to improve and promote quality processes and efficiencies. (spherion.com)
  • Importantly, reproducibility of research results across KPMP sites requires standardized processes and high levels of quality control at each step, such as biopsy procurement, preservation, storage, and analysis, as well as data generation and validation. (nih.gov)
  • Data Quality Control Checklist to help you access the quality of the data you've collected for your registry. (nih.gov)
  • It includes many practices that a laboratory already uses to ensure quality testing beyond requiring that a certain number of QC materials be tested at a designated frequency. (cdc.gov)
  • Training and Certification Programs - to educate staff, through courses and other means, on the conduct of high quality clinical research including training in "Good Clinical Practices. (nih.gov)
  • Provided no Republicans are replaced by Democrats before then, Robinson will give the GOP a 7-6 edge that could result in less stringent air quality policies. (ocregister.com)
  • Previously reported clinical outcomes from the trial showed that islet transplantation prevents severe hypoglycemia and improves blood glucose awareness and control. (nih.gov)
  • Application of traditional clinical pathology quality control techniques to molecular pathology. (nih.gov)
  • With the increase in equipment reliability, the use of kit-based assays, and the desire to provide the highest quality clinical data, we began applying traditional clinical pathology quality control tools to the molecular diagnostics laboratory. (nih.gov)
  • There are some generic activities that help to ensure quality in a clinical research environment. (nih.gov)
  • The Randox Acusera Urinalysis Quality Control is designed primarily to ensure accurate test system performance however offer the laboratory additional benefits that will help them to meet regulatory requirements whilst also reducing costs and time. (randox.com)
  • The Acusera Liquid Urinalysis Control can be used for POCT as well as laboratory based testing. (randox.com)
  • The Acusera Liquid Urinalysis Quality Control is a true third party control designed to provide an unbiased assessment of performance with a range of instruments and methods, helping your laboratory meet the ISO 15189 requirements . (randox.com)
  • the Official Medicines Control the monograph standards and is approved by the competent laboratory (OMCl) network - in particular, the networks for authority. (nih.gov)
  • To ensure high quality, sustainable water quality testing, monitoring and surveillance, WHO provided mobile water quality and safety testing kits to the National Public Health Laboratory to establish water quality control testing hub within the national public health laboratory in Juba. (who.int)
  • If you want high-quality results from your machine learning and artificial intelligence models, you need high-quality training data. (smartdatacollective.com)
  • A QC option is now available that provides laboratories the opportunity to tailor an individualized quality control plan (IQCP) for their unique testing environment and patients. (cdc.gov)
  • As a leading provider of multi-analyte, third party controls, Randox helps busy laboratories significantly reduce the number of controls needed to cover their test menu. (randox.com)
  • The following responsibility standards from the Code of Ethics and Professional Conduct are demonstrated in the "Ethics and quality control" sidebar and are applicable to all aspects of the project. (dummies.com)
  • The mQC quality control metric ensures that good quality combination screening results are analyzed and followed up. (nih.gov)
  • Consistent with 42 CFR Part 11, the National Library of Medicine (NLM) will publicly post submitted results information within 30 days of submission, regardless of whether the quality control (QC) review process is complete. (nih.gov)
  • If nanomechanical testing is to evolve into a tool for process and quality control in semiconductor fabrication, great advances in throughout, repeatability, and accuracy of the associated instruments and measurements will be required. (nist.gov)
  • As a Quality Control Tech you will test inspect, and measure products at various stages of production process and compiles and evaluates statistical data to determine and maintain quality and reliability of products. (spherion.com)
  • You will need to know the outputs for the Control Quality process for the PMP Certification Exam. (dummies.com)
  • The quality measurements are recorded as indicated in the Plan Quality Management process. (dummies.com)
  • Air gages are an accurate, reliable and inexpensive metrology tool used in the quality control process of production. (qualitymag.com)
  • A curator takes it through a quality control process to ensure that no private patient data is available, the image is of good quality, and so forth. (nih.gov)
  • We required a quality control (QC) process prior to the CDW release to the study teams. (nih.gov)
  • Though an annotation tool automates aspects of data entry, most require human input when dealing with exceptions and quality control. (smartdatacollective.com)
  • The typical adjustable restriction between the regulator and air tool controls the magnification while the second adjustable restrictor releases excess air to adjust the zero position. (qualitymag.com)
  • Interprets engineering drawings, schematic diagrams, or formulas and confers with management or engineering staff to determine quality and reliability standards. (spherion.com)
  • The Randox Liquid Urinalysis Control combines multiple analytes into a single control reduces cost, preparation time, and required storage space without sacrificing quality. (randox.com)
  • mQC accurately reproduces the expert assessment of combination response quality and correctly identifies unreliable response matrices that can lead to erroneous or misleading characterization of synergy. (nih.gov)
  • Recommends modifications of existing quality or production standards to achieve optimum quality within limits of equipment capability. (spherion.com)
  • For example, Ergotron medical carts are fully certified to UL/EN/IEC 60601-1 and CAN/CSA C22.2 No.601.1 M90 standards that regulate Electrical Medical Devices. (ergotron.com)
  • You will evaluate your current quality activities and develop an IQCP worksheet which, when completed, can serve as your IQCP document. (cdc.gov)
  • Thank you for your assistance in helping us evaluate the quality of our training products. (cdc.gov)
  • The GCBC will evaluate the quantity and quality of investigator-supplied DNA or RNA, then prepare libraries for short- or long- read sequencing. (nih.gov)
  • One year after their first transplant, 42 participants (88 percent) were free of severe hypoglycemic events, had established near-normal blood glucose control, and had restored awareness of hypoglycemia. (nih.gov)
  • The study design incorporated four well-established, commercially available quality-of-life surveys that were given to participants repeatedly before and after islet transplantation. (nih.gov)
  • This will also help to raise the profile of water quality issues on the national development agenda and encourage the Government of South Sudan to incorporate water quality into national development goals by raising the awareness of policy-makers and practitioners both within and outside the water sector on critical linkages of water quality with other development challenges. (who.int)
  • To assist in preventing problems with data quality, investigators must incorporate standard research methodology into their studies. (nih.gov)
  • Our products undergo extensive testing that exceeds the industry's most rigid quality expectations. (ergotron.com)
  • Insight-driven industrial design combined with engineered ergonomics and uncompromising quality and safety delivers long-lasting products and peace of mind to resellers and customers. (ergotron.com)
  • Inaccurately entered data can lead to serious quality control issues, but data annotations can help a lot. (smartdatacollective.com)
  • Good quality of drinking water is essential for human life! (who.int)
  • Using a fixed regulation to control incoming air pressure, this system has a second adjustable restriction in the feed line which is opposite the output leg. (qualitymag.com)
  • Official Control Authority Batch Release (OCABR) - and the graphs or general chapters. (nih.gov)
  • Full cart certification eliminates any fear of EMI (Electromagnetic Interference) and controls leakage to NFPA levels. (ergotron.com)
  • Pancreatic islets release the hormone insulin, which helps control blood glucose levels. (nih.gov)
  • People with the disease must take insulin to live, but insulin injections or pumps cannot control blood glucose levels as precisely as insulin released naturally from the pancreas. (nih.gov)
  • Approximately half of the transplant recipients needed to continue taking insulin to control their blood glucose levels. (nih.gov)
  • The proof-of-principle study helps pave the way for AI-based quality control of therapeutic cells and tissues. (nih.gov)
  • This study was very rigorous both in terms of the number of measures used to assess quality of life and the number of evaluations performed," said paper co-author Nancy D. Bridges, M.D., chief of the Transplantation Branch at NIAID. (nih.gov)
  • The HPV QC Group shall be responsible for maintaining the quality of the trial's HPV DNA testing. (nih.gov)
  • The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website. (cdc.gov)
  • The quality of your DNA sample before sequencing is directly correlated with the accuracy of your sequencing results. (the-scientist.com)
  • We analyzed control samples (pure and mixed) for two different microsatellites to establish quality control parameters and constructed Levey-Jennings charts to monitor both the precision and accuracy of this assay. (nih.gov)
  • The hub will be used to test and monitor the quality of water in order to determine the status of water quality and safety in the country. (who.int)
  • Although insulin therapy is life-saving, type 1 diabetes remains an extremely challenging condition to manage," said NIAID Director Anthony S. Fauci, M.D. "For people unable to safely control type 1 diabetes despite optimal medical management, islet transplantation offers hope for improving not only physical health but also overall quality of life. (nih.gov)
  • While the air quality board and city councils are non-partisan, Whitaker and state GOP Chairman Jim Brulte are working to build Republican influence at the local level as part of a long-range plan to gain build muscle at the statewide level. (ocregister.com)
  • As a highly qualified, independent third-party, we have the trusted skills and resources to perform quality control. (sgs.com)