Pyrroles. Medical search

Azoles of one NITROGEN and two double bonds that have aromatic chemical properties.

Phenolic metacyclophanes derived from condensation of PHENOLS and ALDEHYDES. The name derives from the vase-like molecular structures. A bracketed [n] indicates the number of aromatic rings.

Polymers where the main polymer chain comprises recurring amide groups. These compounds are generally formed from combinations of diamines, diacids, and amino acids and yield fibers, sheeting, or extruded forms used in textiles, gels, filters, sutures, contact lenses, and other biomaterials.

A group of compounds containing the porphin structure, four pyrrole rings connected by methine bridges in a cyclic configuration to which a variety of side chains are attached. The nature of the side chain is indicated by a prefix, as uroporphyrin, hematoporphyrin, etc. The porphyrins, in combination with iron, form the heme component in biologically significant compounds such as hemoglobin and myoglobin.

The location of the atoms, groups or ions relative to one another in a molecule, as well as the number, type and location of covalent bonds.

Oligopeptide antibiotics from Streptomyces distallicus. Their binding to DNA inhibits synthesis of nucleic acids.

Six-carbon saturated hydrocarbon group of the methane series. Include isomers and derivatives. Various polyneuropathies are caused by hexane poisoning.

A group of ALKALOIDS, characterized by a nitrogen-containing necine, occurring mainly in plants of the BORAGINACEAE; COMPOSITAE; and LEGUMINOSAE plant families. They can be activated in the liver by hydrolysis of the ester and desaturation of the necine base to reactive electrophilic pyrrolic CYTOTOXINS.

A pyrrolizidine alkaloid and a toxic plant constituent that poisons livestock and humans through the ingestion of contaminated grains and other foods. The alkaloid causes pulmonary artery hypertension, right ventricular hypertrophy, and pathological changes in the pulmonary vasculature. Significant attenuation of the cardiopulmonary changes are noted after oral magnesium treatment.

A chemical element having an atomic weight of 106.4, atomic number of 46, and the symbol Pd. It is a white, ductile metal resembling platinum, and following it in abundance and importance of applications. It is used in dentistry in the form of gold, silver, and copper alloys.

6-carbon straight-chain or branched ketones.

Ring compounds having atoms other than carbon in their nuclei. (Grant & Hackh's Chemical Dictionary, 5th ed)

Changing an open-chain hydrocarbon to a closed ring. (McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)

3-Chloro-4-(3-chloro-2-nitrophenyl)pyrrole. Antifungal antibiotic isolated from Pseudomonas pyrrocinia. It is effective mainly against Trichophyton, Microsporium, Epidermophyton, and Penicillium.

Compounds with a 5-membered ring of four carbons and an oxygen. They are aromatic heterocycles. The reduced form is tetrahydrofuran.

Rhodium. A hard and rare metal of the platinum group, atomic number 45, atomic weight 102.905, symbol Rh. (Dorland, 28th ed)

A basic polypeptide isolated from Streptomyces netropsis. It is cytotoxic and its strong, specific binding to A-T areas of DNA is useful to genetics research.

The covalent bonding of an alkyl group to an organic compound. It can occur by a simple addition reaction or by substitution of another functional group.

The facilitation of a chemical reaction by material (catalyst) that is not consumed by the reaction.

Linear TETRAPYRROLES that give a characteristic color to BILE including: BILIRUBIN; BILIVERDIN; and bilicyanin.

A republic consisting of a group of about 100 islands and islets in the western Pacific Ocean. Its capital is Koror. Under Spain it was administered as a part of the Caroline Islands but was sold to Germany in 1899. Seized by Japan in 1914, it was taken by the Allies in World War II in 1944. In 1947 it became part of the U.S. Trust Territory of the Pacific Islands, became internally self-governing in 1980, obtained independent control over its foreign policy (except defense) in 1986, and achieved total independence October 1, 1994. (Webster's New Geographical Dictionary, 1988, p915; telephone communication with Randy Flynn, Board on Geographic Names, 17 January 1995)

Spectroscopic method of measuring the magnetic moment of elementary particles such as atomic nuclei, protons or electrons. It is employed in clinical applications such as NMR Tomography (MAGNETIC RESONANCE IMAGING).

A genus of large, brightly colored SPONGES in the family Agelasidae, possessing a skeleton of spongin fibers with a core of large spicules (megascleres).

That portion of the electromagnetic spectrum from the UHF (ultrahigh frequency) radio waves and extending into the INFRARED RAYS frequencies.

The phenomenon whereby compounds whose molecules have the same number and kind of atoms and the same atomic arrangement, but differ in their spatial relationships. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)

Inorganic or organic compounds derived from phosphine (PH3) by the replacement of H atoms. (From Grant & Hackh's Chemical Dictionary, 5th ed)

1,3,6,7-Tetramethyl-4,5-dicarboxyethyl-2,8-divinylbilenone. Biosynthesized from hemoglobin as a precursor of bilirubin. Occurs in the bile of AMPHIBIANS and of birds, but not in normal human bile or serum.

The characteristic three-dimensional shape of a molecule.

Hydrocarbons with at least one triple bond in the linear portion, of the general formula Cn-H2n-2.

Compounds formed by the joining of smaller, usually repeating, units linked by covalent bonds. These compounds often form large macromolecules (e.g., BIOPOLYMERS; PLASTICS).

Models used experimentally or theoretically to study molecular shape, electronic properties, or interactions; includes analogous molecules, computer-generated graphics, and mechanical structures.

Negatively charged atoms, radicals or groups of atoms which travel to the anode or positive pole during electrolysis.

An antineoplastic agent derived from BLEOMYCIN.

Benzopyrroles with the nitrogen at the number one carbon adjacent to the benzyl portion, in contrast to ISOINDOLES which have the nitrogen away from the six-membered ring.

Unsaturated hydrocarbons of the type Cn-H2n, indicated by the suffix -ene. (Grant & Hackh's Chemical Dictionary, 5th ed, p408)

Inorganic salts of the hypothetical acid, H3Fe(CN)6.

Organic compounds containing a carbonyl group in the form -CHO.

A class of compounds of the type R-M, where a C atom is joined directly to any other element except H, C, N, O, F, Cl, Br, I, or At. (Grant & Hackh's Chemical Dictionary, 5th ed)

The color-furnishing portion of hemoglobin. It is found free in tissues and as the prosthetic group in many hemeproteins.

Imidazole derivative anesthetic and hypnotic with little effect on blood gases, ventilation, or the cardiovascular system. It has been proposed as an induction anesthetic.

Porphyrins with four methyl, two vinyl, and two propionic acid side chains attached to the pyrrole rings. Protoporphyrin IX occurs in hemoglobin, myoglobin, and most of the cytochromes.

The theory that the radiation and absorption of energy take place in definite quantities called quanta (E) which vary in size and are defined by the equation E=hv in which h is Planck's constant and v is the frequency of the radiation.

A group of compounds derived from ammonia by substituting organic radicals for the hydrogens. (From Grant & Hackh's Chemical Dictionary, 5th ed)

The study of chemical changes resulting from electrical action and electrical activity resulting from chemical changes.

The phylum of sponges which are sessile, suspension-feeding, multicellular animals that utilize flagellated cells called choanocytes to circulate water. Most are hermaphroditic. They are probably an early evolutionary side branch that gave rise to no other group of animals. Except for about 150 freshwater species, sponges are marine animals. They are a source of ALKALOIDS; STEROLS; and other complex molecules useful in medicine and biological research.

Compounds containing 1,3-diazole, a five membered aromatic ring containing two nitrogen atoms separated by one of the carbons. Chemically reduced ones include IMIDAZOLINES and IMIDAZOLIDINES. Distinguish from 1,2-diazole (PYRAZOLES).

A low-energy attractive force between hydrogen and another element. It plays a major role in determining the properties of water, proteins, and other compounds.

The parts of a macromolecule that directly participate in its specific combination with another molecule.

The relationship between the chemical structure of a compound and its biological or pharmacological activity. Compounds are often classed together because they have structural characteristics in common including shape, size, stereochemical arrangement, and distribution of functional groups.

Analysis of the intensity of Raman scattering of monochromatic light as a function of frequency of the scattered light.

Organic compounds containing the -CO-NH2 radical. Amides are derived from acids by replacement of -OH by -NH2 or from ammonia by the replacement of H by an acyl group. (From Grant & Hackh's Chemical Dictionary, 5th ed)

The study of crystal structure using X-RAY DIFFRACTION techniques. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)

Organic nitrogenous bases. Many alkaloids of medical importance occur in the animal and vegetable kingdoms, and some have been synthesized. (Grant & Hackh's Chemical Dictionary, 5th ed)

Electric conductors through which electric currents enter or leave a medium, whether it be an electrolytic solution, solid, molten mass, gas, or vacuum.

Substances used for the detection, identification, analysis, etc. of chemical, biological, or pathologic processes or conditions. Indicators are substances that change in physical appearance, e.g., color, at or approaching the endpoint of a chemical titration, e.g., on the passage between acidity and alkalinity. Reagents are substances used for the detection or determination of another substance by chemical or microscopical means, especially analysis. Types of reagents are precipitants, solvents, oxidizers, reducers, fluxes, and colorimetric reagents. (From Grant & Hackh's Chemical Dictionary, 5th ed, p301, p499)

A deoxyribonucleotide polymer that is the primary genetic material of all cells. Eukaryotic and prokaryotic organisms normally contain DNA in a double-stranded state, yet several important biological processes transiently involve single-stranded regions. DNA, which consists of a polysugar-phosphate backbone possessing projections of purines (adenine and guanine) and pyrimidines (thymine and cytosine), forms a double helix that is held together by hydrogen bonds between these purines and pyrimidines (adenine to thymine and guanine to cytosine).

The art or process of comparing photometrically the relative intensities of the light in different parts of the spectrum.

Higher-order DNA and RNA structures formed from guanine-rich sequences. They are formed around a core of at least 2 stacked tetrads of hydrogen-bonded GUANINE bases. They can be formed from one two or four separate strands of DNA (or RNA) and can display a wide variety of topologies, which are a consequence of various combinations of strand direction, length, and sequence. (From Nucleic Acids Res. 2006;34(19):5402-15)

A rigorously mathematical analysis of energy relationships (heat, work, temperature, and equilibrium). It describes systems whose states are determined by thermal parameters, such as temperature, in addition to mechanical and electromagnetic parameters. (From Hawley's Condensed Chemical Dictionary, 12th ed)

The measurement of the quantity of heat involved in various processes, such as chemical reactions, changes of state, and formations of solutions, or in the determination of the heat capacities of substances. The fundamental unit of measurement is the joule or the calorie (4.184 joules). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)

The phenomenon whereby certain chemical compounds have structures that are different although the compounds possess the same elemental composition. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)

Binary compounds of oxygen containing the anion O(2-). The anion combines with metals to form alkaline oxides and non-metals to form acidic oxides.

Theoretical representations that simulate the behavior or activity of chemical processes or phenomena; includes the use of mathematical equations, computers, and other electronic equipment.

A chemical reaction in which an electron is transferred from one molecule to another. The electron-donating molecule is the reducing agent or reductant; the electron-accepting molecule is the oxidizing agent or oxidant. Reducing and oxidizing agents function as conjugate reductant-oxidant pairs or redox pairs (Lehninger, Principles of Biochemistry, 1982, p471).

Liquids that dissolve other substances (solutes), generally solids, without any change in chemical composition, as, water containing sugar. (Grant & Hackh's Chemical Dictionary, 5th ed)

The measurement of the amplitude of the components of a complex waveform throughout the frequency range of the waveform. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)

Fractionation of a vaporized sample as a consequence of partition between a mobile gaseous phase and a stationary phase held in a column. Two types are gas-solid chromatography, where the fixed phase is a solid, and gas-liquid, in which the stationary phase is a nonvolatile liquid supported on an inert solid matrix.

An atom or group of atoms that have a positive or negative electric charge due to a gain (negative charge) or loss (positive charge) of one or more electrons. Atoms with a positive charge are known as CATIONS; those with a negative charge are ANIONS.

Liquid chromatographic techniques which feature high inlet pressures, high sensitivity, and high speed.

A basic science concerned with the composition, structure, and properties of matter; and the reactions that occur between substances and the associated energy exchange.

Prior exposure to neurotrophins blocks inhibition of axonal regeneration by MAG and myelin via a cAMP-dependent mechanism. (1/4084)

MAG is a potent inhibitor of axonal regeneration. Here, inhibition by MAG, and myelin in general, is blocked if neurons are exposed to neurotrophins before encountering the inhibitor; priming cerebellar neurons with BDNF or GDNF, but not NGF, or priming DRG neurons with any of these neurotrophins blocks inhibition by MAG/myelin. Dibutyryl cAMP also overcomes inhibition by MAG/myelin, and cAMP is elevated by neurotrophins. A PKA inhibitor present during priming abrogates the block of inhibition. Finally, if neurons are exposed to MAG/myelin and neurotrophins simultaneously, but with the Gi protein inhibitor, inhibition is blocked. We suggest that priming neurons with particular neurotrophins elevates cAMP and activates PKA, which blocks subsequent inhibition of regeneration and that priming is required because MAG/myelin activates a Gi protein, which blocks increases in cAMP. This is important for encouraging axons to regrow in vivo. (+info)

Increased lipophilicity and subsequent cell partitioning decrease passive transcellular diffusion of novel, highly lipophilic antioxidants. (2/4084)

Oxidative stress is considered a cause or propagator of acute and chronic disorders of the central nervous system. Novel 2, 4-diamino-pyrrolo[2,3-d]pyrimidines are potent inhibitors of iron-dependent lipid peroxidation, are cytoprotective in cell culture models of oxidative injury, and are neuroprotective in brain injury and ischemia models. The selection of lead candidates from this series required that they reach target cells deep within brain tissue in efficacious amounts after oral dosing. A homologous series of 26 highly lipophilic pyrrolopyrimidines was examined using cultured cell monolayers to understand the structure-permeability relationship and to use this information to predict brain penetration and residence time. Pyrrolopyrimidines were shown to be a more permeable structural class of membrane-interactive antioxidants where transepithelial permeability was inversely related to lipophilicity or to cell partitioning. Pyrrole substitutions influence cell partitioning where bulky hydrophobic groups increased partitioning and decreased permeability and smaller hydrophobic groups and more hydrophilic groups, especially those capable of weak hydrogen bonding, decreased partitioning, and increased permeability. Transmonolayer diffusion for these membrane-interactive antioxidants was limited mostly by desorption from the receiver-side membrane into the buffer. Thus, in this case, these in vitro cell monolayer models do not adequately mimic the in vivo situation by underestimating in vivo bioavailability of highly lipophilic compounds unless acceptors, such as serum proteins, are added to the receiving buffer. (+info)

Involvement of phosphodiesterase-cGMP-PKG pathway in intracellular Ca2+ oscillations in pituitary GH3 cells. (3/4084)

The present study investigates the potential role of the Ca2+-calmodulin-dependent type I phosphodiesterase (PDE)-cGMP-protein kinase G (PKG) pathway in spontaneous [Ca2+]i oscillations in GH3 cells using fura-2 single cell videoimaging. Vinpocetine (2.5-50 microM), a selective inhibitor of type I PDE, induced a concentration-dependent inhibition of spontaneous [Ca2+]i oscillations in these pituitary cells, and at the same time produced an increase of the intracellular cGMP content. The cell permeable cGMP analog N2,2'-O-dibutyryl-cGMP (dB-cGMP) (1 mM) caused a progressive reduction of the frequency and the amplitude of spontaneous [Ca2+]i oscillations when added to the medium. KT5823 (400 nM), a selective inhibitor of cGMP-dependent protein kinase (PKG), produced an increase of baseline [Ca2+]i and the disappearance of spontaneous [Ca2+]i oscillations. When KT5823 was added before vinpocetine, the PKG inhibitor counteracted the [Ca2+]i lowering effect of the cGMP catabolism inhibitor. Finally, the removal of extracellular Ca2+ or the blockade of L-type voltage-sensitive calcium channels (VSCC) by nimodipine produced a decrease of cytosolic cGMP levels. Collectively, the results of the present study suggest that spontaneous [Ca2+]i oscillations in GH3 cells may be regulated by the activity of type I PDE-cGMP-PKG pathway. (+info)

Characterization of a novel, non-peptidyl antagonist of the human glucagon receptor. (4/4084)

We have identified a series of potent, orally bioavailable, non-peptidyl, triarylimidazole and triarylpyrrole glucagon receptor antagonists. 2-(4-Pyridyl)-5-(4-chlorophenyl)-3-(5-bromo-2-propyloxyphenyl)p yrr ole (L-168,049), a prototypical member of this series, inhibits binding of labeled glucagon to the human glucagon receptor with an IC50 = 3. 7 +/- 3.4 nM (n = 7) but does not inhibit binding of labeled glucagon-like peptide to the highly homologous human glucagon-like peptide receptor at concentrations up to 10 microM. The binding affinity of L-168,049 for the human glucagon receptor is decreased 24-fold by the inclusion of divalent cations (5 mM). L-168,049 increases the apparent EC50 for glucagon stimulation of adenylyl cyclase in Chinese hamster ovary cells expressing the human glucagon receptor and decreases the maximal glucagon stimulation observed, with a Kb (concentration of antagonist that shifts the agonist dose-response 2-fold) of 25 nM. These data suggest that L-168,049 is a noncompetitive antagonist of glucagon action. Inclusion of L-168, 049 increases the rate of dissociation of labeled glucagon from the receptor 4-fold, confirming that the compound is a noncompetitive glucagon antagonist. In addition, we have identified two putative transmembrane domain residues, phenylalanine 184 in transmembrane domain 2 and tyrosine 239 in transmembrane domain 3, for which substitution by alanine reduces the affinity of L-168,049 46- and 4. 5-fold, respectively. These mutations do not alter the binding of labeled glucagon, suggesting that the binding sites for glucagon and L-168,049 are distinct. (+info)

Characterization of the pyoluteorin biosynthetic gene cluster of Pseudomonas fluorescens Pf-5. (5/4084)

Ten genes (plt) required for the biosynthesis of pyoluteorin, an antifungal compound composed of a bichlorinated pyrrole linked to a resorcinol moiety, were identified within a 24-kb genomic region of Pseudomonas fluorescens Pf-5. The deduced amino acid sequences of eight plt genes were similar to the amino acid sequences of genes with known biosynthetic functions, including type I polyketide synthases (pltB, pltC), an acyl coenzyme A (acyl-CoA) dehydrogenase (pltE), an acyl-CoA synthetase (pltF), a thioesterase (pltG), and three halogenases (pltA, pltD, and pltM). Insertions of the transposon Tn5 or Tn3-nice or a kanamycin resistance gene in each of these genes abolished pyoluteorin production by Pf-5. The presumed functions of the eight plt products are consistent with biochemical transformations involved in pyoluteorin biosynthesis from proline and acetate precursors. Isotope labeling studies demonstrated that proline is the primary precursor to the dichloropyrrole moiety of pyoluteorin. The deduced amino acid sequence of the product of another plt gene, pltR, is similar to those of members of the LysR family of transcriptional activators. pltR and pltM are transcribed divergently from the pltLABCDEFG gene cluster, and a sequence with the characteristics of a LysR binding site was identified within the 486-bp intergenic region separating pltRM from pltLABCDEFG. Transcription of the pyoluteorin biosynthesis genes pltB, pltE, and pltF, assessed with transcriptional fusions to an ice nucleation reporter gene, was significantly greater in Pf-5 than in a pltR mutant of Pf-5. Therefore, PltR is proposed to be a transcriptional activator of linked pyoluteorin biosynthesis genes. (+info)

Promotion of antibiotic production by high ethanol, high NaCl concentration, or heat shock in Pseudomonas fluorescens S272. (6/4084)

A stress imposed by a continuous feed of high ethanol, high NaCl concentration, or a high temperature shock increased antibiotic production by several times in Pseudomonas fluorescens S272. A tentative bioassay showed that the stress caused about 40-fold elevation in the autoinducer activity. Addition of synthetic autoinducers, N-(3-oxododecanoyl)-L-homoserine lactone or N-(3-oxohexanoyl)-L-homoserine lactone at a concentration of more than 100 micrograms/l to a non-stressed culture also increased the antibiotic production by several times. These results suggested that the antibiotic production in P. fluorescens S272 was regulated by N-acyl-homoserine lactone and the promotive effect by stress occurred through any function that increased the autoinducer production. (+info)

Peripheral urocortin delays gastric emptying: role of CRF receptor 2. (7/4084)

Urocortin, a new mammalian member of the corticotropin-releasing factor (CRF) family has been proposed to be the endogenous ligand for CRF receptor 2 (CRF-R2). We studied the influence of intravenous urocortin on gastric emptying and the role of CRF-R2 in peptide action and postoperative gastric ileus in conscious rats. The intravenous doses of rat CRF and rat urocortin producing 50% inhibition of gastric emptying were 2.5 and 1.1 microgram/kg, respectively. At these intravenous doses, CRF and urocortin have their actions fully reversed by the CRF-R1/CRF-R2 antagonist astressin at antagonist/agonist ratios of 5:1 and 67:1, respectively. Astressin (12 microgram/kg iv) completely prevented abdominal surgery-induced 54% inhibition of gastric emptying 3 h after surgery while having no effect on basal gastric emptying. The selective nonpeptide CRF-R1 antagonists antalarmin (20 mg/kg ip) and NBI-27914 (400 microgram/kg iv) did not influence intravenous CRF-, urocortin- or surgery-induced gastric stasis. These results as well as earlier ones showing that alpha-helical CRF9-41 (a CRF-R2 more selective antagonist) partly prevented postoperative ileus indicate that peripheral CRF-R2 may be primarily involved in intravenous urocortin-, CRF-, and abdominal surgery-induced gastric stasis. (+info)

Inhibition of PC-3 human androgen-independent prostate cancer and its metastases by cytotoxic somatostatin analogue AN-238. (8/4084)

We evaluated whether AN-238, the cytotoxic analogue of somatostatin (SST) consisting of the radical 2-pyrrolinodoxorubicin (AN-201) linked covalently to the SST octapeptide carrier RC-121 (D-Phe-Cys-Tyr-D-Trp-Lys-Val-Cys-Thr-NH2), could be used for targeting human primary and metastatic prostate carcinomas that express SST receptors (SSTRs). The antitumor activity and toxicity of AN-238 and its components were first characterized in nude mice bearing s.c. xenografts of PC-3 human androgen-independent prostate cancer. In experiment 1, AN-238 was injected once i.v. at 200 nmol/kg when the mean volume of s.c. tumors was about 30 mm3. Administration of AN-238 inhibited tumor growth, as shown by a 74% decrease in tumor volume and by a 71% reduction in tumor weight after 7 weeks as compared with the control group. AN-201 at an equimolar dose did not show any antitumor activity. The mortality was 14.3% (one of seven mice) in the AN-238-treated group and 47% (three of seven mice) in mice that received AN-201. In experiment 2, two i.v. injections of AN-238 at 150 nmol/kg were given 10 days apart when the tumors measured 65-70 mm3. A significant inhibition of tumor volume (62.3%; P < 0.001) and tumor weight (61.1%; P < 0.01) was observed after 4 weeks of treatment. AN-201, given alone at the same dose or coadministered with RC-121, had no significant effect on PC-3 tumors. The suppression of tumor growth induced by AN-238 was accompanied by a significant enhancement of apoptosis (P < 0.01). There were similar side effects in all treated groups, which included a transient loss of body weight and leukopenia. The effectiveness of AN-238 in a metastatic model was then investigated in animals implanted orthotopically with 2 x 10(6) PC-3 cells. Two i.v. injections of AN-238 or AN-201 at 150 nmol/kg were administered 10 days apart at 10 weeks after intraprostatic inoculation of PC-3 cells. After 4 weeks of treatment, the mean weight of primary tumors in animals receiving AN-238 was 77% lower (P < 0.01) than that in controls. This reduction was also significantly greater (P < 0.05) than that in animals given AN-201, which showed only a 34% inhibition (nonsignificant versus controls). All control animals and four of six (67%) mice treated with AN-201 developed metastases in the lymph nodes; however, no lymphatic spread of cancer was found in the AN-238-treated group. Using reverse transcription-PCR analysis, we demonstrated the expression of SSTR2 and SSTR5 in intraprostatic tumors and their metastases in lymph nodes as well as in s.c. tumors. The present study demonstrates the high efficacy of SSTR-targeted chemotherapy in a model of advanced human androgen-independent prostatic carcinoma, as shown by the inhibition of primary tumors and their metastases by the cytotoxic SST analogue AN-238. (+info)

... aus Azinen" [Synthesis of pyrrole derivatives: pyrrole from diethyl succinyl succinate, pyrrole from azines]. Berichte ... In contrast, substituted pyrroles (including protected pyrroles) have been used in a broad range of transformations. Pyrroles ... Pyrrole aldehydes can be formed by a Vilsmeier-Haack reaction. N-Acylation of simple pyrrole does not occur.[citation needed] ... Pyrrole has a nutty odor. Pyrrole is a 5-membered aromatic heterocycle, like furan and thiophene. Unlike furan and thiophene, ...

https://en.wikipedia.org/wiki/Pyrrole

... (PIPs) are a class of polyamides have the ability to bind to minor grooves found in the DNA helix ... Wu, Chunlei; Wang, Wei; Fang, Lijing; Su, Wu (July 2018). "Programmable pyrrole-imidazole polyamides: A potent tool for DNA ... Kawamoto, Yusuke; Bando, Toshikazu; Sugiyama, Hiroshi (May 2018). "Sequence-specific DNA binding Pyrrole-imidazole polyamides ...

https://en.wikipedia.org/wiki/Pyrrole–imidazole_polyamides

3-dicarbonylated pyrroles can be synthesized by a version of the Hantzsch Pyrrole Synthesis. These pyrroles are particularly ... Alternative methods for synthesizing pyrroles exist, such as the Knorr Pyrrole Synthesis and Paal-Knorr Synthesis. Below is one ... Pyrroles are found in a variety of natural products with biological activity, so the synthesis of substituted pyrroles has ... The Hantzsch Pyrrole Synthesis, named for Arthur Rudolf Hantzsch, is the chemical reaction of β-ketoesters (1) with ammonia (or ...

https://en.wikipedia.org/wiki/Hantzsch_pyrrole_synthesis

The Knorr pyrrole synthesis is a widely used chemical reaction that synthesizes substituted pyrroles (3). The method involves ... Paine, John B.; Dolphin, David (1985). "Pyrrole chemistry. An improved synthesis of ethyl pyrrole-2-carboxylate esters from ... Knorr's pyrrole can be derivatized in a number of useful manners. One equivalent of sodium hydroxide will saponify the 2-ester ... Hantzsch pyrrole synthesis Paal-Knorr synthesis (CS1 German-language sources (de), CS1 Italian-language sources (it), Use dmy ...

https://en.wikipedia.org/wiki/Knorr_pyrrole_synthesis

... pyrrole + CO2 (2) pyrrole-2-carboxylate + H2O ⇌ {\displaystyle \rightleftharpoons } pyrrole + HCO3− The enzyme catalyses both ... Pyrrole-2-carboxylate decarboxylase (EC 4.1.1.93) is an enzyme with systematic name pyrrole-2-carboxylate carboxy-lyase. This ... doi:10.1016/s0040-4039(98)00718-7. Pyrrole-2-carboxylate+decarboxylase at the US National Library of Medicine Medical Subject ... Wieser M, Fujii N, Yoshida T, Nagasawa T (October 1998). "Carbon dioxide fixation by reversible pyrrole-2-carboxylate ...

https://en.wikipedia.org/wiki/Pyrrole-2-carboxylate_decarboxylase

... (EC 1.14.13.130, pyrrole-2-carboxylate oxygenase) is an enzyme with systematic name pyrrole ... Pyrrole-2-carboxylate+monooxygenase at the US National Library of Medicine Medical Subject Headings (MeSH) Portal: Biology ( ... Becker D, Schräder T, Andreesen JR (November 1997). "Two-component flavin-dependent pyrrole-2-carboxylate monooxygenase from ... H2O Pyrrole-2-carboxylate monooxygenase is a flavoprotein (FAD). Hormann K, Andreesen JR (March 1994). "Purification and ...

https://en.wikipedia.org/wiki/Pyrrole-2-carboxylate_monooxygenase

... is an organic compound with the formula HNC4H3CO2H. It is one of two monocarboxylic acids of pyrrole ... It also arises by carboxylation of pyrrole. The ethyl ester of this acid is readily prepared from pyrrole. Thomas, Michael G.; ... doi:10.1016/S1381-1177(00)00038-2. Denis M. Bailey, Robert E. Johnson, and Noel F. Albertson (1971). "Ethyl Pyrrole-2- ... Wieser, Marco; Yoshida, Toyokazu; Nagasawa, Toru (2001). "Carbon dioxide fixation by reversible pyrrole-2-carboxylate ...

https://en.wikipedia.org/wiki/Pyrrole-2-carboxylic_acid

... is an organic chemical compound with formula C6H9O2N, or (HOCH2)2(C4H3N). Its molecule can be ... The compound can be synthesized by formylation of pyrrole followed by reduction of the resulting pyrrolecarboxaldehyde. ... pyrrole and tripyrrane derivatives". Tetrahedron. 57 (11): 2103-2108. doi:10.1016/S0040-4020(01)00059-X. (Chemical pages ... described as that of pyrrole C4H5N with hydroxymethyl groups HO−CH2− replacing the two hydrogen atoms adjacent to the nitrogen ...

https://en.wikipedia.org/wiki/2,5-Bis(hydroxymethyl)pyrrole

Walsh, Christopher T.; Garneau-Tsodikova, Sylvie; Howard-Jones, Annaleise R. (2006). "Biological formation of pyrroles: ... This contains two pyrrole rings built from proline and serine as shown in the blue-shaded pathway in Figure 1. The aldehyde is ... subsequently condensed with a third pyrrole to form prodigiosin (compound 16 in Figure 1), which is then further elaborated to ...

https://en.wikipedia.org/wiki/Prodiginines

Under acid catalysis, pyrrole and ketones R−(C=O)−R' or aldehydes R−(C=O)−H condense to give many oligomers, including the ... Alternatively, pyrrole with sidechains substituted at carbons 3 and 4 (those not adjacent to the nitrogen) can be condensed ... Porphyrins differ from porphyrinogens by having the four pyrrole rings linked by methine bridges =CH− instead of methylene ... Meso-substituted porphyrinogens with eight non-hydrogen side chains are also called calix[4]pyrroles. These products resist ...

https://en.wikipedia.org/wiki/Porphyrinogen

Pyrrole can be prepared industrially by reacting furan and ammonia in the presence of solid acid catalysts, such as SiO2 and ... "Pyrrole". Ullmann's Encyclopedia of Industrial Chemistry. Weinheim: Wiley-VCH. doi:10.1002/14356007.a22_453. Anese, M.; ...

https://en.wikipedia.org/wiki/Furan

Reaction of pyrroles with dichlorocarbene". Journal of the Chemical Society C: Organic (18): 2249. doi:10.1039/J39690002249. ... The Ciamician-Dennstedt rearrangement entails the ring-expansion of pyrrole with dichlorocarbene to 3-chloropyridine. In the ...

https://en.wikipedia.org/wiki/Pyridine

1, p. 245 Paine, John B.; Dolphin, David (1985-12-01). "Pyrrole chemistry. An improved synthesis of ethyl pyrrole-2-carboxylate ... 4-diketones to boiling acetic acid to afford in maximal yield variously substituted ethyl pyrrole-2-carboxylates of interest ...

https://en.wikipedia.org/wiki/Diethyl_malonate

Ciamician-Dennstedt rearrangement Ciamician, G.; Dennestedt, M. (1881). Ciamician synthesis of pyridines from pyrroles. Chem. ...

https://en.wikipedia.org/wiki/Giacomo_Ciamician

Cyr, D. J.; Arndtsen, B. A., A New Use of Wittig-type Reagents as 1,3-Dipolar Cycloaddition Precursors and in Pyrrole Synthesis ... doi:10.1021/ol4035512) Organic Chemistry Portal pyrrole synthesis abstract: "A New Use of Wittig-Type Reagents as 1,3-Dipolar ... Multicomponent Synthesis of Pyrrole-Based pi-Conjugated Polymers from Imines, Acid Chlorides, and Alkynes. J. Am. Chem. Soc. ... and pyrroles. The latter heterocyclic products were obtained by multi-component reactions involving in situ-generation of ...

https://en.wikipedia.org/wiki/Montréalone

"Paal-Knorr Pyrrole Synthesis", Comprehensive Organic Name Reactions and Reagents, Hoboken, NJ, USA: John Wiley & Sons, Inc., pp ... Lamellarins are a group of pyrrole alkaloids first isolated in 1985 from the marine mollusk Lamellaria in the waters of Palau. ... Pyrrole Bailly, Christian; Newman, David J. (2015). Written at Pierre Fabre Research Institute. "Download Limit Exceeded". ... They are divided into two groups, depending on whether the pyrrole ring is fused or unfused. The lamellarins have been ...

https://en.wikipedia.org/wiki/Lamellarin_D

The Barton-Zard reaction is a route to pyrrole derivatives via the reaction of a nitroalkene with an α-isocyanoacetate under ... pp.43-4 Barton, Derek H. R.; Zard, Samir Z. (1985). "A new synthesis of pyrroles from nitroalkenes". Journal of the Chemical ... Ono, Noboru (2008). "Barton-Zard Pyrrole Synthesis and Its Application to Synthesis of Porphyrins, Polypyrroles, and ... An extension of the barton-zard pyrrole condensation". Tetrahedron Letters. 35 (16): 2493-2494. doi:10.1016/S0040-4039(00)77152 ...

https://en.wikipedia.org/wiki/Barton–Zard_reaction

Whereas the pyrrole molecule is planar, the arsole molecule is not, and the hydrogen atom bonded to arsenic extends out of the ... Pyrrole, a nitrogen analog. Furan, an oxygen analog. Thiophene, a sulfur analog. Simple aromatic rings Varsol, a petroleum ... It is classified as a metallole and is isoelectronic to and related to pyrrole except that an arsenic atom is substituted for ... The planarity is lost even in pyrrole when its nitrogen-bonded hydrogen atom is substituted, e.g., with fluorine. However, the ...

https://en.wikipedia.org/wiki/Arsole

Diaz, A. F.; Kanazawa, K. Keiji; Gardini, Gian Piero (1979). "Electrochemical polymerization of pyrrole". Journal of the ...

https://en.wikipedia.org/wiki/Organic_semiconductor

ISBN 978-1-4398-1382-9. {{cite book}}: ,first1= has generic name (help) A., Gossauer (1974). Die Chemie der Pyrrole. Berlin, ...

https://en.wikipedia.org/wiki/Streptomyces_rishiriensis

... no 13C incorporation was observed in the pyrrole ring of PBP. In 2004, a follow-up study described the PBP pyrrole ring as ... Of more than 20 classified pyrrole antibiotics, PBP is the most active member in its class, and demonstrates a high in vitro ... 2. The Pyrrole Ring". Bioscience, Biotechnology, and Biochemistry. 69 (3): 628-630. doi:10.1271/bbb.69.628. PMID 15784994. ... PBP was first isolated and reported in 1966, when Burkholder and colleagues identified an unusual, highly brominated pyrrole ...

https://en.wikipedia.org/wiki/Pentabromopseudilin

It is made by condensation of pyrrole with acetone. The pyrrolic N-H centers of ctamethylporphyrinogen can be deprotonated, and ... Baeyer, Adolf (1886). "Ueber ein Condensationsproduct von Pyrrol mit Aceton". Berichte der Deutschen Chemischen Gesellschaft. ... pyrroles". Journal of the American Chemical Society. 118 (49): 12471-12472. doi:10.1021/ja9632217. Bachmann, Julien; Hodgkiss, ... meso-octamethyl indicates that the eight methyl groups are located on the carbon centers that interconnect the four pyrrole ...

https://en.wikipedia.org/wiki/Meso-Octamethylporphyrinogen

"Zur Kenntnis der Pyrrole, 4. Mitteilung: Über Pyrrol-aldehyde (II.) und über Pyrrol-nitrile," Berichte der deutschen chemischen ... "Zur Kenntnis der Pyrrole, 1. Mitteilung: Über Pyrrol-aldehyde", Berichte der deutschen chemischen Gesellschaft, Volume 55, ... "Zur Kenntnis der Pyrrole, 3. Mitteilung: Über Ketone, Ketonsäure-ester und Ketonsäure-nitrile substituierter Pyrrole," Berichte ... Issue 6, pages 1942-1949, 1922, doi:10.1002/cber.19220550645 Hans Fischer, Werner Zerweck, "Zur Kenntnis der Pyrrole, 2. ...

https://en.wikipedia.org/wiki/Werner_Zerweck

... who reported the formation of pyrrole blacks from pyrrole magnesium bromide. Since then pyrrole oxidation reaction has been ... Chemical oxidation of pyrrole: n C4H4NH + 2n FeCl3 → (C4H2NH)n + 2n FeCl2 + 2n HCl The process is thought to occur via the ... Polypyrrole (PPy) is an organic polymer obtained by oxidative polymerization of pyrrole. It is a solid with the formula H( ... This electrophile attacks the C-2 carbon of an unoxidized molecule of pyrrole to give a dimeric cation [(C4H4NH)2]++. The ...

https://en.wikipedia.org/wiki/Polypyrrole

p. 437-8. ISBN 0-7167-3539-3. "Aromatic Heterocycles- Pyridine and Pyrrole". Chemistry Libre Texts. 3 May 2015. p. 15.5. ...

https://en.wikipedia.org/wiki/Hückel's_rule

PigB oxidises the resulting ring using oxygen and FAD+, yielding the pyrrole. Finally, the two pieces are combined by pigC and ... The biosynthesis of prodigiosin and related analogs, the prodiginines involves the convergent coupling of three pyrrole type ... Walsh, Christopher T.; Garneau-Tsodikova, Sylvie; Howard-Jones, Annaleise R. (2006). "Biological formation of pyrroles: ... as the coenzyme to yield pyrrole ring A. In the first step, proline is attached to a peptidyl carrier protein (PCP) called pigG ...

https://en.wikipedia.org/wiki/Prodigiosin

... pyrroles". Journal of the American Chemical Society. 120 (8). doi:10.1021/ja973656+. C., Vollhardt, K. Peter (2018-01-29). ...

https://en.wikipedia.org/wiki/Electrophilic_aromatic_directing_groups

The asymmetric hydrogenation of 2,3,5-substituted N-Boc pyrroles Unprotected 2,5-pyrroles may also be hydrogenated ... Such an analysis led to the development of a ruthenium(I)/phosphine/amine base system for 2,3,5-substituted N-Boc pyrroles that ... The asymmetric hydrogenation of 2,3,5-substituted pyrroles was achieved by the recognition that such substrates bear the same ... Achieving complete conversion of pyrroles to pyrrolidines by asymmetric hydrogenation has so far proven difficult, with partial ...

https://en.wikipedia.org/wiki/Asymmetric_hydrogenation

Jackson, A. H.; Smith, K. M. (1973). "The Total Synthesis of Pyrrole Pigments". In Apsimon, John (ed.). Total Synthesis of ...

https://en.wikipedia.org/wiki/Vitamin_B12_total_synthesis

Hantzsch pyrrole synthesis Bechara, William S.; Charette, André B.; Na, Risong; Wang, Wenliang; Zheng, Chao (2020). "Diethyl 1, ...

https://en.wikipedia.org/wiki/Hantzsch_ester

... Molecular Formula: C12H12N2O2 ...

https://scitoys.com/scichem/jqp046/236793.html

... *Formula: C6H7NO2- ...

https://webbook.nist.gov/cgi/cbook.cgi?ID=B2413&Units=CAL

Pyrrole Red Oil found in: DANIEL SMITH Original Oil Colors, ...

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TCI uses cookies to personalize and improve your user experience. By continuing on our website, you accept the use of cookies. You can change or update your cookiesettings at any time.. ...

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Ne ratez pas nos trucs & astuces pratiques, les dernières actualités ainsi que des idées pour ...

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The reaction is applicable to both indole and pyrrole substrates, and a variety of substituents are tolerated. The entire ... Catalyst-free facile synthesis of polycyclic indole/pyrrole substituted-1,2,3-triazoles J. Gour, S. Gatadi, R. Akunuri, M. V. ... The reaction is applicable to both indole and pyrrole substrates, and a variety of substituents are tolerated. The entire ... This methodology provides a sustainable and efficient access to a variety of novel polycyclic indole/pyrrole substituted-1,2,3- ...

https://pubs.rsc.org/en/Content/ArticleLanding/2019/OB/C9OB01560D

Order Golden Open Acrylic Colors Pyrrole Orange 8 Oz. Jar (7276-5) today at Quill.com and get fast shipping. Stack coupons to ... Golden Open Acrylic Colors Pyrrole Orange 8 Oz. Jar (7276-5). Order Golden Open Acrylic Colors Pyrrole Orange 8 Oz. Jar (7276-5 ... Golden Open Acrylic Colors Pyrrole Orange 8 Oz. Jar (7276-5) $60.99 Each IN-STOCK. Limited quantity. available 1 Remaining) ...

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ta[c]pyrrol-3a(1H)-. ylmethyl]ethandiamid [German] [ACD/IUPAC Name] N-(4-Chloro-3-fluor. ophenyl)-N-[(3aS,6. aS)- ... enta[c]pyrrol-3a(1H. )-ylmethyl]ethanedi. amide [ACD/IUPAC Name] N-(4-Chloro-3-fluor. ophényl)-N-[(3aS,6. aS)-hexahydrocyclop ... a[c]pyrrol-3a(1H)-ylmethyl]eth. anediamide *Molecular FormulaC16H19ClFN3O2 ... enta[c]pyrrol-3a(1H. )-ylméthyl]éthanedi. amide [French] [ACD/IUPAC Name] ...

http://www.chemspider.com/Chemical-Structure.26375578.html

... furans/pyrroles. Water is the only byproduct in the atom economic, selective synthesis of 1,4-diynes and pyrroles, whereas the ... Atom-Economical Chemoselective Synthesis of 1,4-Diynes and Polysubstituted Furans/Pyrroles from Propargyl Alcohols and Terminal ...

https://www.organic-chemistry.org/abstracts/lit3/316.shtm

Nicole Phungrasamee Fein 21.09.25.01 Pyrrol Red Cadmium Yellow Deep Hue Cobalt Blue, 2021 watercolor on paper 18 x 18 in 45.7 x ...

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is China manufacturers & exporters of 2-Acetyl pyrrole ... China 2-Acetyl pyrrole Suppliers, China 2-Acetyl pyrrole ...

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... Molecular Formula: C23H20Cl3N3O3 ... 3-[[3-(azepane-1-carbonyl)phenyl]amino]-4-chloro-1-(3,5-dichlorophenyl)pyrrole-2,5-dione ...

https://sci-toys.com/scichem/jqp013/1682637.html

Daniel Smith 15 ml Watercolour Pyrrol Scarlet. Permanent, semi-transparent to semi-opaque and medium staining, this fire engine ...

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The pyrrole dimer is used as a model for microsolvation, where a new decay pathway opens, relating to relaxation into ... The role of πσ* states in the ultrafast non-radiative dynamics of pyrrole, aniline and phenol. Doctoral thesis , UCL ( ... Chapter 3 examines the UV relaxation dynamics of pyrrole, where the lowest excited singlet state is of πσ* character. We ... The role of πσ* states in the ultrafast non-radiative dynamics of pyrrole, aniline and phenol ...

https://discovery.ucl.ac.uk/id/eprint/1460824/

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Deproto-metallation of N-arylated pyrroles and indoles using a mixed lithium-zinc base and regioselectivity-computed CH acidity ... Deproto-metallation of N-arylated pyrroles and indoles using a mixed lithium-zinc base and regioselectivity-computed CH acidity ...

https://www.beilstein-journals.org/bjoc/articles/11/160/downloads

In addition to the X-ray analysis, the NMR spectra indicated that dihydropyrrolo[3,2-b]pyrrole was a typical heteroaromatic ... Publications] S. Tanaka; T. Kumagai; T. Mukai; T. Kobayashi: 1,4-Dihydropyrrolo[3,2-b]pyrrole: The Electronic Structure ... Heteroaromaticity / Pyrrole / Electron-Donating Ability / Ionization Potential / Conductive Polymer Firm / Heterocyclic ... Physical and chemical properties of 1,4-dihydropyrrolo[3,2-b]pyrroles synthesized in this project were systematically ...

https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-60470021/

5-nitro-1H-pyrrole-2-carboxylic acid ethyl ester. An open source of chemical information available to the public online since ... Home >> Chemical Listing >> D >> 1-(2,2-Diethoxyethyl)-5-nitro-1H-pyrrole-2-carboxylic acid ethyl ester ... 1-(2,2-Diethoxyethyl)-5-nitro-1H-pyrrole-2-carboxylic acid ethyl ester [1105187-49-2] ... List of Reports Available for 1-(2,2-Diethoxyethyl)-5-nitro-1H-pyrrole-2-carboxylic acid ethyl ester ...

https://www.chemblink.com/products/1105187-49-2.htm

1H-PYRROL-2-YL)BENZO[CD]INDOL-2(1H)-ONE: Overview ... 5-[(2-AMINOETHYL)AMINO]-6-FLUORO-3-(1H-PYRROL-2-YL)BENZO[CD] ... Pyrrole / Secondary aliphatic/aromatic amine / Secondary amine / Secondary carboxylic acid amide / Substituted pyrrole. ... Naphthalenes / Indoles and derivatives / Secondary alkylarylamines / Substituted pyrroles / Aryl fluorides / Heteroaromatic ... 5-[(2-AMINOETHYL)AMINO]-6-FLUORO-3-(1H-PYRROL-2-YL)BENZO[CD]INDOL-2(1H)-ONE. DrugBank Accession Number. DB07163. Background. ...

https://go.drugbank.com/drugs/DB07163

Formation of lysyl-pyrrole cross-links (Homo sapiens) * Collagen type I fibrils with lysyl-pyrrole cross-links [extracellular ... Collagen type I fibrils with lysyl-pyrrole cross-links [extracellular region] Stable Identifier ... Collagen type I fibril with lysyl-pyrrole cross-links [extracellular region] (Homo sapiens) ... Collagen type I fibrils with lysyl-pyrrole cross-links [extracellular region] (Bos taurus) ...

https://reactome.org/content/detail/R-HSA-2396474

Buy from Pyrrol-2-Carboxylic Acid Manufacturer, Supplier in Palghar, Maharashtra, India. ...

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A facile three-step synthesis of 2-(2-aminophenyl)pyrrole (1) and 2-(2- aminomethylphenyl)pyrrole (2) is reported by use of ... pyrrole derivatives}, keyword = {synthesis of aminoarylpyrroles, Suzuki-Miyaura coupling, 2-(o-substituted aryl)pyrroles, Pd- ... pyrrole derivatives}, keyword = {synthesis of aminoarylpyrroles, Suzuki-Miyaura coupling, 2-(o-substituted aryl)pyrroles, Pd- ... Optimization of the Suzuki coupling reaction in the synthesis of 2-[(2-substituted)phenyl]pyrrole derivatives // Journal of ...

https://www.bib.irb.hr/495072

1H-pyrrole-2-carboxylate from AK Scientific, in San Francisco, California ... methyl 1-{[3-(2-methylphenyl)-1,2,4-oxadiazol-5-yl]methyl}-1H-pyrrole-2-carboxylate. , >90%. Add to Favorites ... 1H-pyrrole-2-carboxylic acid, 1-[[3-(2-methylphenyl)-1,2,4-oxadiazol-5-yl]methyl]-, methyl ester. ...

https://aksci.com/item_detail.php?cat=HTS000022

Pyrrol-2-methylketone. Description. 2-acetylpyrrole, also known as 1-(1h-pyrrol-2-yl)1-ethanone or 2-pyrrolyl methyl ketone, is ... Pyrrol-2-methylketone, non-derivatized, Predicted GC-MS Spectrum - 70eV, Positive. Not Available. Spectrum. ... Pyrrol-2-methylketone, non-derivatized, Predicted GC-MS Spectrum - 70eV, Positive. splash10-0006-9100000000- ...

https://foodb.ca/compounds/FDB004573

The N-Methyl Pyrrole Market research contains a complete competitive analysis that includes the size, share, and company ...

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Chemicals and Drugs [D] » Heterocyclic Compounds [D03] » Heterocyclic Compounds, 1-Ring » Azoles » Pyrroles ...

https://www.cdek.liu.edu/mesh/D011758/

Tag: New Family of High-Density Energetic Materials based on Pyrrole: Synthesis and Exploration of Energetic Properties.. ...

http://herald.uohyd.ac.in/tag/new-family-of-high-density-energetic-materials-based-on-pyrrole-synthesis-and-exploration-of-energetic-properties/

... WU Mei-Fen, WEN Zhao-Yin, LIU ... 15) Wu, M. F.;Wen, Z. Y.; Liu, Y.; Huang, L. Z. Morphology and electrochemical behavior of Li metal behavior with pyrrole ... Effects of Tetrahydrofuran Pretreatment on the Performance of Pyrrole Modified Li Metal Electrode[J].Acta Phys. -Chim. Sin., ... Channel of Electronic Interactions in Diferrocenyl Pyrrole Derivatives [J]. Acta Phys. -Chim. Sin., 2015, 31(2): 227-236. ...

http://www.whxb.pku.edu.cn/EN/abstract/abstract27581.shtml

Dipyrrolyldiketone BF2 complexes with amide units at pyrrole α-positions were synthesized in modest yields and showed extremely ... Conjunction of Pyrrole and Amide Moieties: Highly Anion-Responsive π-Electronic Molecules Forming Ion-Free and Ion-Pairing ... Dipyrrolyldiketone BF2 complexes with amide units at pyrrole α-positions were synthesized in modest yields and showed extremely ... A good reception: Dipyrrolyldiketone BF2 complexes with amide units at pyrrole α-positions were synthesized and showed ...

https://www.researcher-app.com/paper/21204

Water is the only byproduct in the atom economic, selective synthesis of 1,4-diynes and pyrroles, whereas the synthesis of furans is fully atom economic. (organic-chemistry.org)
A facile three-step synthesis of 2-(2-aminophenyl)pyrrole (1) and 2-(2- aminomethylphenyl)pyrrole (2) is reported by use of Suzuki coupling of N-Boc-pyrrol-2-yl boronic acid (3) and o-substituted aryl halogenides, followed by hydrogenation. (irb.hr)
Alešković, M., Basarić, N. & Mlinarić-Majerski, K. (2011) Optimization of the Suzuki coupling reaction in the synthesis of 2-[(2-substituted)phenyl]pyrrole derivatives. (irb.hr)
New Family of High-Density Energetic Materials based on Pyrrole: Synthesis and Exploration of Energetic Properties. (uohyd.ac.in)
The facile Copper-catalyzed synthesis of polysubstituted pyrroles from aldehydes, amines and β-nitroalkenesis reported. (sussex.ac.uk)
Pyrroles are normally produced in small numbers as a byproduct of hemoglobin synthesis and excreted in the urine. (drnicoladucharme.com)
A facile synthesis of substituted pyrroles over montmorrilonite KSF clay has been accomplished in excellent yield. (heterocycles.jp)
76. Practical Synthesis of Ethyl 3-Fluoro-1-Pyrrole-2 Carboxylate: a Key Fragment of a potent drug candidate against Hepatitis B virus. (insa-rouen.fr)
Congratulations to Suchand, Samrat Sahu, and Shuvendu for publishing their paper on Cp*Co(III)-Catalyzed Dehydrative C2-Prenylation of Pyrrole and Indole with Allyl Alcohols in Advance Synthesis and Catalysis! (msmlabiitkgp.com)

2-acetylpyrrole, also known as 1-(1h-pyrrol-2-yl)1-ethanone or 2-pyrrolyl methyl ketone, is a member of the class of compounds known as aryl alkyl ketones. (foodb.ca)
Remarkably, the use of α-methyl substituted aldehydes provide efficient access to a series of tetra- and pentasubstituted pyrroles via an overwhelming 1,2-phenyl/alkyl migration. (sussex.ac.uk)
Manufacturer and Supplier of Intermediates & Side Chains : CIMC Chloride-3-(2-Chlorophenyl)-5-Methyl Pyrrole. (needsinfo.com)

Why pyridine is more basic than Pyrrole? (chemzipper.com)

The reaction is applicable to both indole and pyrrole substrates, and a variety of substituents are tolerated. (rsc.org)
This methodology provides a sustainable and efficient access to a variety of novel polycyclic indole/pyrrole substituted-1,2,3-triazoles. (rsc.org)

Based on formal kinetic studies, a possible radical pathway is proposed that involves the formation of an allylic nitrogen radical intermediate, which in turn reacts with the nitroalkene to yield the desired pyrrole framework via a radical 1,2-phenyl or alkyl migration. (sussex.ac.uk)

Dipyrrolyldiketone BF2 complexes with amide units at pyrrole α-positions were synthesized in modest yields and showed extremely high anion-binding affinities because of multiple hydrogen-bonding interactions. (researcher-app.com)
Examination of anion-binding behavior using 1H NMR spectroscopy combined with theoretical studies suggested fast pyrrole inversions, particularly for the phenyl-amide-substituted derivative. (researcher-app.com)
A good reception: Dipyrrolyldiketone BF2 complexes with amide units at pyrrole α-positions were synthesized and showed extremely high anion-binding affinities through multiple hydrogen bonding (see figure). (researcher-app.com)

K. Murase: 'Electropolymerization of N,N-Dimethyl-Pyrrolo[3,2-b]pyrrole: New Heteroaromatic Polymer. (nii.ac.jp)

Clariant is the only pigment producer to offer high-performance Diketopyrrolo Pyrrole (DPP) pigments, such as Pigment Red 254 and other red, pink and violet shades, based on renewable raw materials. (coatingsworld.com)

Under different conditions, the reaction of propargyl alcohols and terminal alkynes leads to the selective formation of 1,4-diynes and polysubstituted furans/pyrroles. (organic-chemistry.org)

T. Mukai: 'Acid-Induced Rearrangements of 2,8-Diazabicyclo[3.2.1]octa-3,6-dienes leading to 1,4-Dihydropyridine and Pyrrole Derivatives. (nii.ac.jp)

Reseach of New Heterocycles: Pyrrolo-pyrrole and Azapentalene. (nii.ac.jp)

Order Golden Open Acrylic Colors Pyrrole Orange 8 Oz. Jar (7276-5) today at Quill.com and get fast shipping. (quill.com)
it feels slightly chaotic with the black swirl fighting with the Pyrrole Orange and green in the lower right corner. (jennynewman.org)
otherwise I mix Indanthrone, Transparent Pyrrol Orange, and Quinacridone Burnt Orange. (doodlewash.com)

Cholesterol oxidase has been immobilized in conducting copolymers of thiophene-3-yl acetic acid cholesteryl ester with pyrrole (CM/PPy) and polypyrrole (PPy) via electropolymerization. (metu.edu.tr)

Physical and chemical properties of 1,4-dihydropyrrolo[3,2-b]pyrroles synthesized in this project were systematically investigated. (nii.ac.jp)

T. Kumagai: 'Electrochemical Studies of Fused-Pyrrole System. (nii.ac.jp)
Anion-binding behavior examined by 1H NMR spectroscopy along with theoretical studies suggested rapid pyrrole inversions in solution state. (researcher-app.com)

This was a pyrrole ring similar to many such produced in the human body each with their own unique variation in composition, some of which are used in the production of heme which is a porphyrin used to carry iron in haemoglobin. (biochemicalhealth.org)
In 1975 Irvine had already announced that with further technical improvements it had been established that 'kryptopyrrole' was the wrong identification for the Mauve factor, and that it was instead the similar pyrrole most commonly known today as Hydroxyhemopyrrolin-2-one or HPL. (biochemicalhealth.org)

Pyrroluria is a condition in which the the body produces excess of pyrroles. (drnicoladucharme.com)

The present methodology is also accessible to non α-substituted aldehydes yielding the corresponding trisubstituted pyrroles. (sussex.ac.uk)

Chapter 3 examines the UV relaxation dynamics of pyrrole, where the lowest excited singlet state is of πσ* character. (ucl.ac.uk)

Includes: Titanium White Hansa Yellow Medium Yellow Oxide Pyrrole Red Quinacridone Magenta Ultramarine Blue Phthalo Blue Phthalo Green Burnt Sienna and Carbon Black. (jerrysartarama.com)

Dithieno[3,2-b:2′,3′-d]pyrrole (DTP) derivatives are one of the most important organic photovoltaic materials due to better π-conjugation across fused thiophene rings. (syr.edu)
Pyrrole, furan and thiophene undergo electrophilic substitution reactions like nitration, sulphonation, halogenation etc. characteristic of aromatic rings. (chemzipper.com)
Graft copolymers of poly(vinyl alcohol) with thiophene side-groups and pyrrole were synthesized by electrochemical polymerization methods. (itu.edu.tr)
Organic heterocyclic compounds that consist of a thiophene ring fused to a pyrrole ring. (fishersci.com)
Quinoidal heterocyclic (thiophene, pyrrole, furan, etc .) molecules have the characteristics of rigid backbone, low highest occupied molecular orbital (HOMO)/lowest unoccupied molecular orbital (LUMO) level, narrow band gap and high molar extinction coefficient, and so on. (sioc-journal.cn)

In this work, two new hole transport materials (HTMs), H16 and H18, have been obtained through a facile synthetic route by cross linking triarylamine-based donor groups with a 4-(4-methoxyphenyl)-4H-dithieno[3,2-b:2′,3′-d]pyrrole (MPDTP) and N-(4-(4H-dithieno[3,2 b:2′,3′-d]pyrrol-4-yl)phenyl)-4-methoxy-N-(4-methoxyphenyl)aniline (TPDTP) unit, respectively. (syr.edu)

Microwave-assisted reactions are also covered to understand green chemistry aspects of pyrrole and its derivatives. (eurekaselect.com)

Therefore, pyridine is a stronger base than Pyrrole . (philosophy-question.com)
Why is pyrrole more reactive than pyridine? (philosophy-question.com)
Pyrrole is more reactive than pyridine for electrophilic substitution reactions because of the stability of the protonated pyrrole intermediate. (philosophy-question.com)
Pyridine is more stable in its unreacted state compare to pyrrole due to its aromatic nature. (philosophy-question.com)
Which is a stronger base pyridine or pyrrole? (philosophy-question.com)
Thus, pyridine is a stronger base than pyrrole . (philosophy-question.com)
We have recorded the O-atom velocity map photofragment ion images resulting from the photodissociation of O2-pyrrole and O2-pyridine clusters near 226 nm. (elsevier.com)
Both O2-pyrrole and O2-pyridine also show a low kinetic energy process that appears to be isotropic in nature. (elsevier.com)
Parsons, BF & Szpunar, DE 2020, ' Investigation of O 2 -X (X = Pyrrole or Pyridine) Cluster Photodissociation near 226 nm ', Journal of Physical Chemistry A , vol. 124, no. 49, pp. 10152-10161. (elsevier.com)

Pyrrole is a five membered ring with one nitrogen and two carbon-carbon double bonds. (enotes.com)
Pyrrole is one of the main five membered heterocyclic systems reported for its various chemotherapeutic activities. (eurekaselect.com)
In case of Pyrrole the lone pair electrons of the nitrogen atom is involved in conjugated system of pi electrons of five membered ring leading to greater stability of the molecule due to acquiring aromatic character. (philosophy-question.com)
Pyrrole is a heterocyclic aromatic organic compound, a five-membered ring with the formula C4H4NH. (philosophy-question.com)
Pyrrole is a five-membered aromatic heterocyclic ring with nitrogen as the heteroatom. (writix.co.uk)

Transparent Pyrrole Orange has been demonstrated to have excellent stability and lightfastness in automotive applications. (dickblick.com)

Different types of corroles and porphyrins are synthesized from substituted aldehydes and pyrrole. (ias.ac.in)
By varying the amounts of reactants (i.e., pyrrole and aldehydes), the corrole and porphyrins were obtained ingood to excellent yields. (ias.ac.in)

abstract = "pi-Conjugated microporous networks have been prepared from the tetraarylated diketopyrrolo[3,4-c]pyrrole unit as a tetrafunctional building block. (strath.ac.uk)

Our Scarlet Pyrrol is a vivid fiery orange with incredible strength. (mgraham.com)

The wild-type showed clorobiocin as the main product, whereas the cloN2 mutant accumulated a new aminocoumarin derivative, novclobiocin 104, lacking the pyrrole moiety at the 3-OH of the deoxysugar. (microbiologyresearch.org)
These results prove an involvement of cloN2 in the formation of the ester bond between the pyrrole moiety and the deoxysugar in clorobiocin biosynthesis. (microbiologyresearch.org)
Furthermore, they indicate that the C -methylation at position 5 of the pyrrole moiety occurs after the attachment of pyrrole-2-carboxylic acid unit to the deoxysugar moiety. (microbiologyresearch.org)
Pyrrole moiety is involved in the structure of many classes of drugs as well as natural active constituents such as: alkaloids. (writix.co.uk)
Several strategies of modification were followed: varying substituents on the pyrrole carboxamide moiety, alteration of the central scaffold, including variation of substitution position and, most importantly, modification of the oxalyl moiety. (jic.ac.uk)

Desulfurization of the pyrrole thiolesters was investigated, and the column reaction was introduced to improve the yield of the products. (mun.ca)
A new co-polymer based on fragments of 2-(2-pyridyl)monoazatriphenylene and 2,5-bis (2-ethylhexyl)-3,6-di(thiophen-2-yl)pyrrolo[3,4- c ]pyrrole-1,4(2 H ,5 H )-dione was prepared by using the Sonogashira reaction. (urfu.ru)
Reaction of N-(2′-hydroxyphenyl)pyrrole-2-aldimine (H 2 L) with [M(PPh 3 ) 3 Cl] (M = Rh, Ir) affords complexes of type [M(PPh 3 ) 2 (L)Cl]. (ias.ac.in)
Early studies have shown that as long as the pyrrole bears an electron withdrawing group on the 2-position the reaction sequence is highly tolerant of substitution. (ukri.org)

We recently reported that eight-ring hairpin-polyamides containing 3-hydroxypyrrole (Hp), imidazole (Im), and pyrrole (Py) amino acids form four-ring pairings (Im/Py, Py/Im, Hp/Py, and Py/Hp) which distinguish the four Watson-Crick base pairs in the minor groove of DNA. (caltech.edu)
Pyrrole-imidazole polyamides are ligands that bind in the minor groove of DNA with high affinity and sequence selectivity. (scripps.edu)
A set of eight-ring hairpin-motif pyrrole-imidazole polyamides has been designed to bind within the binding site for the human cytomegalovirus (CMV) UL122 immediate early protein 2 (IE86). (scripps.edu)
A mismatch polyamide, containing a single imidazole to pyrrole substitution, and also a polyamide binding to a site located 14 base pairs upstream of the repressor binding site, do not prevent IE86 binding to the crs. (scripps.edu)
These results demonstrate that this new class of small molecules, the pyrrole-imidazole polyamides, are not only effective inhibitors of basal and activated transcription, but also can be used to activate transcription by blocking the DNA-binding activity of a repressor protein. (scripps.edu)
3. Nuclear Localization and Gene Expression Modulation by a Fluorescent Sequence-Selective p-Anisyl-benzimidazolecarboxamido Imidazole-Pyrrole Polyamide. (nih.gov)
6. Binding of f-PIP, a pyrrole- and imidazole-containing triamide, to the inverted CCAAT box-2 of the topoisomerase IIalpha promoter and modulation of gene expression in cells. (nih.gov)
11. Targeting the ICB2 site of the topoisomerase IIalpha promoter with a formamido-pyrrole-imidazole-pyrrole H-pin polyamide. (nih.gov)
Pyrrole-imidazole polyamide-mediated silencing of KCNQ1OT1 expression induces cell death in Wilms' tumor cells. (cdc.gov)

Why is pyrrole aromatic in nature? (philosophy-question.com)
Pyrrole is considered an aromatic heterocycle as it satisfies Huckel's rule (4n+2) with two pi bonds in the conjugated system representing 4 electrons and one lone pair of electrons on nitrogen atom to give a total of 6 pi electrons. (writix.co.uk)
Pyrrole is more activated towards electrophilic aromatic substitution than benzene because the lone pair of electrons on nitrogen atom provides electron density to the ring by resonance which stabilizes the formed sigma complex intermediate more effectively. (writix.co.uk)

2. Furan as raw material, react with ammonia in the catalyst at 400℃ can obtain tetrahydro pyrrole. (hotelpentagone.com)
Furan is not as reactive as pyrrole in electrophilic substitution reactions because the oxygen in furan is more electronegative than nitrogen in pyrrole and therefore does not enhance the electron density of carbons as much as pyrrole. (chemzipper.com)

Pyrrole Disorder webinar: Part 1. (vitamedicine.com.au)
Pyrrole disorder is a complex disorder with numerous signs and symptoms. (vitamedicine.com.au)
Although Pyrrole Disorder is not a new health condition, there has been a large influx of information and misinformation in recent years leading to confusion of the signs, symptoms, and treatment. (vitamedicine.com.au)
Pyrrole disorder can be described as a complex disorder. (vitamedicine.com.au)
The causes of pyrrole disorder are not completely understood. (vitamedicine.com.au)
There has been an influx of people with potential pyrrole disorder in clinic in the last year or so, especially since the website post last year. (vitamedicine.com.au)

Pyrrole is a colourless liquid that darkens on exposure to air with agreeable empyreumatic odour that resembles that of chloroform. (writix.co.uk)

Pyrrole Red is considered to have excellent lightfastness among organic pigments in its class. (dickblick.com)

Both β-hydroxymethyl pyrroles and β-chloromethyl pyrroles are easily converted to β, β¹-dipyrromethanes in acidic medium. (mun.ca)

The syntheses of copolymers Of PVATh and pyrrole were achieved electrochemically by using three different supporting electrolytes, p-toluene sulfonic acid (PTSA), sodium dodecyl sulfate (SDS) and tetrabutylammonium tetrafluoroborate (TBAFB). (itu.edu.tr)
Subsequent electropolymerization with pyrrole through these moities yielded free standing films of the corresponding block and graft copolymers. (metu.edu.tr)

Its IUPAC name is 1H-Pyrrole. (writix.co.uk)

The authors conclude that it is currently unclear whether pyrrolylation is sufficient to induce gamma-diketone neuropathy, or if secondary pyrrole autoxidation is also necessary. (cdc.gov)
1D 1H NMR spectra of stable time point samples from the autoxidation of dicatechol pyrrole lysine confirm two successive products. (nih.gov)

pyrrole acetic acid derivative. (drugs.com)

Enamino acids derived from 1,2-dimethylaminomethylene- or 1,2-hydroxymethylene-carbonyl compounds and amino acids undergo a decarboxylative cyclisation to pyrroles, isoindoles and other fused pyrroles. (hud.ac.uk)
Aqueous solutions containing pyrrole and calix-6-arenehexasulfonic acid were found to undergo polymerization in the absence of either a chemical oxidant or electrochemical oxidation. (edu.au)
A variety of N-butenyl substituted pyrroles have been found to undergo an extraordinary photocycloaddition/rearrangement sequence to give tricyclic fused aziridines of high molecular complexity. (ukri.org)

A new triazole-strapped calix[4]pyrrole synthesised via 'click' chemistry shows high affinity for chloride and lipid bilayer chloride transport properties. (kent.ac.uk)

In both complexes, the N-(2′-hydroxyphenyl)pyrrole-2-aldimine ligand is coordinated to the metal centre, via dissociation of the acidic protons, as a dianionic tridentate N,N,O-donor. (ias.ac.in)

2,5-Bis(2-octyldodecyl)pyrrolo[3,4-c]pyrrole-1,4-(2H,5H)-dione-based donor-acceptor alternating copolymer bearing 5,5′-di(thiophen-2-yl)-2,2′-biselenophene exhibiting 1.5 cm2·V-1·s-1 hole mobility in thin-film transistors. (urfu.ru)
π-Conjugated pol-ymers derived from 2,5-bis(2-decyltetradecyl)-3,6-di(selenophen-2-yl)pyrrolo[3,4-c]pyrrole-1,4(2H,5H)-dione for high-performance thin film transistors. (urfu.ru)
Member of the pyrrolo-pyrrole group of NSAIDs. (medscape.com)

Finally, a number of unexpected results obtained during these studies employing intramolecular conjugate additions of pyrroles to construct the bicyclic or tetracyclic architecture of these Stemona alkaloids, were investigated and rationalised by employing experiment and density functional theory. (edu.au)
Pyrrole ring system is involved in some naturally occurring phyto-compounds such as alkaloids and in some coloured natural products as chlorophyll as well as the heme part of haemoglobin and bile pigments. (writix.co.uk)

Secondary alcohols react with 2-amino alcohols in the presence of benzophenone to yield alkyl or aryl-substituted pyrroles via oxidation of secondary alcohols to ketones then condensation with 2-amino alcohols and cyclization to the target pyrrole ring. (writix.co.uk)

This position was suggestive because its main chain carbonyl is within hydrogen-bonding distance to pyrrole ring nitrogens of the biliverdin chromophore, thus potentially functioning as a crucial transient proton sink during photoconversion. (rcsb.org)

The 5H part of the name means that the nitrogen atom in the pyrrole ring has a hydrogen attached to it. (enotes.com)

Pyrrole Red, used as an automotive paint and as a colorant in plastics, was developed as one of a range of pigments to replace lead based pigments. (dickblick.com)

cas 123-75-1 Pyrrolidine liquid Tetrahydro pyrrole best price safe delivery. (hotelpentagone.com)

Conductivity of Poly(pyrrole)-Poly(styrene sulfonate) Core-Shell Nanoparticles. (mpg.de)

Condensation of 1,4-dicarbonyl compounds in the presence of excess ammonia or amines yields pyrrole or N-substituted pyrroles. (writix.co.uk)
Condensation of carboxylic acid with 2,4,4-trimethoxybutan-1-amine then acid-catalyzed cyclization of the product yields N-acyl substituted pyrroles. (writix.co.uk)

A two atom ring expansion occurs preferentially with enamino acids from cyclohexane-1,3-diones and α-alkyl-α-amino acids leading to oxocino[2,3-c]pyrroles. (hud.ac.uk)
Pyrrole is sp2-hybridized with each carbon atom having a p orbital with one electron and the heteroatom (nitrogen) has a p orbital with two electrons. (writix.co.uk)
The corrin ring has 4 pyrroles, which bind to the cobalt atom. (medscape.com)

The attack of an electrophile on pyrrole, for example, will lead to formation of 2- and 3-substitution products by way of carbocations (1) and (2) respectively.The substitution occurs preferably at C-2 position because the intermediate obtained by attack at this position is more stable than the intermediate obtained by attack at C-3. (chemzipper.com)
New $\beta$-linked pyrrole monomers: approaches to highly stable and conductive electrochromic polymers. (mit.edu)

Pyrrole is almost insoluble in water as it makes intermolecular hydrogen bonding between its own molecules. (writix.co.uk)

Pyrrole Red is opaque and has strong covering power. (dickblick.com)

In 1975 Irvine had already announced that with further technical improvements it had been established that 'kryptopyrrole' was the wrong identification for the Mauve factor, and that it was instead the similar pyrrole most commonly known today as Hydroxyhemopyrrolin-2-one or HPL. (biochemicalhealth.org)

Colour: Pyrrole Red. (lincraft.com.au)

Dynamics simulations based on surface hopping and ADC(2) reveal that pyrrole internal conversion to the ground state occurs not only through H-elimination path, but also through ring-distortion paths, which have been systematically neglected by diverse experimental setups. (archives-ouvertes.fr)

Pyrrole moieties were incorporated at the chain ends of polytetrahydrofuran and polysiloxane and at the side chains of polyethyl vinylether by ionic polymerization and appropriate chemical reactions. (metu.edu.tr)

Polypyrrole/PEOLiClO 4 junctions were prepared in situ by the electrochemical polymerization of pyrrole in the polymer electrolyte PEOLiClO 4 . (elsevier.com)

Subsequently, pyrroles have been highlighted as the important biologically active scaffolds. (eurekaselect.com)

Finally, our ion images for O2-pyrrole show O atoms resulting from a two-photon dissociation channel, which has been previously attributed to the formation and subsequent photodissociation of excited O2 (a 1Îg). (elsevier.com)

Organisms2

Chemicals and Drugs43

Analytical, Diagnostic and Therapeutic Techniques and Equipment11

Phenomena and Processes14

Disciplines and Occupations3

Technology, Industry, Agriculture2

Geographicals1

Prior exposure to neurotrophins blocks inhibition of axonal regeneration by MAG and myelin via a cAMP-dependent mechanism. (1/4084)

Increased lipophilicity and subsequent cell partitioning decrease passive transcellular diffusion of novel, highly lipophilic antioxidants. (2/4084)

Involvement of phosphodiesterase-cGMP-PKG pathway in intracellular Ca2+ oscillations in pituitary GH3 cells. (3/4084)

Characterization of a novel, non-peptidyl antagonist of the human glucagon receptor. (4/4084)

Characterization of the pyoluteorin biosynthetic gene cluster of Pseudomonas fluorescens Pf-5. (5/4084)

Promotion of antibiotic production by high ethanol, high NaCl concentration, or heat shock in Pseudomonas fluorescens S272. (6/4084)

Peripheral urocortin delays gastric emptying: role of CRF receptor 2. (7/4084)

Inhibition of PC-3 human androgen-independent prostate cancer and its metastases by cytotoxic somatostatin analogue AN-238. (8/4084)

Pyrroles

Calixarenes

Nylons

Porphyrins

Molecular Structure

Distamycins

Hexanes

Pyrrolizidine Alkaloids

Benzaldehydes

Monocrotaline

Palladium

Hexanones

Imines

Heterocyclic Compounds

Cyclization

Pyrrolnitrin

Furans

Rhodium

Netropsin

Alkylation

Catalysis

Bile Pigments

Palau

Magnetic Resonance Spectroscopy

Agelas

Microwaves

Stereoisomerism

Phosphines

Biliverdine

Ketones

Molecular Conformation

Alkynes

Polymers

Models, Molecular

Anions

Peplomycin

Indoles

Alkenes

Ferricyanides

Aldehydes

Organometallic Compounds

Heme

Etomidate

Protoporphyrins

Vinyl Compounds

Quantum Theory

Amines

Electrochemistry

Porifera

Imidazoles

Hydrogen Bonding

Binding Sites

Structure-Activity Relationship

Spectrum Analysis, Raman

Amides

Crystallography, X-Ray

Alkaloids

Electrodes

Indicators and Reagents

DNA

Spectrophotometry

G-Quadruplexes

Thermodynamics

Calorimetry

Isomerism

Oxides

Models, Chemical

Oxidation-Reduction

Solvents

Spectrum Analysis

Chromatography, Gas

Ions

Chromatography, High Pressure Liquid

Chemistry

Prior exposure to neurotrophins blocks inhibition of axonal regeneration by MAG and myelin via a cAMP-dependent mechanism. (1/4084)

Increased lipophilicity and subsequent cell partitioning decrease passive transcellular diffusion of novel, highly lipophilic antioxidants. (2/4084)

Involvement of phosphodiesterase-cGMP-PKG pathway in intracellular Ca2+ oscillations in pituitary GH3 cells. (3/4084)

Characterization of a novel, non-peptidyl antagonist of the human glucagon receptor. (4/4084)

Characterization of the pyoluteorin biosynthetic gene cluster of Pseudomonas fluorescens Pf-5. (5/4084)

Promotion of antibiotic production by high ethanol, high NaCl concentration, or heat shock in Pseudomonas fluorescens S272. (6/4084)