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Pyridoxal PhosphatePyridoxalPyridoxal KinasePyridoxinePyridoxaminePhosphatesVitamin B 6 DeficiencyBorohydridesTransaminasesTryptophan SynthaseAspartate AminotransferasesApoenzymesPyridoxaminephosphate OxidaseVitamin B 6LyasesKineticsGlycine HydroxymethyltransferaseSchiff BasesPhosphorylasesD-Alanine TransaminasePyridoxic AcidL-Serine DehydrataseTyrosine Phenol-LyaseSpectrophotometryCarboxy-LyasesOrnithine-Oxo-Acid TransaminaseBinding SitesSemicarbazidesIminesEscherichia coliCalcium PhosphatesSpectrophotometry, UltravioletTyrosine DecarboxylaseHydrogen-Ion ConcentrationGlucose-6-PhosphateGlyceraldehyde-3-Phosphate DehydrogenasesAldehydesSugar PhosphatesHemoglobin C DiseaseTryptophanaseLysinePhosphorylase bPimelic AcidsCysteine SynthaseCystathionine beta-SynthaseSubstrate Specificity5-Aminolevulinate SynthetasePlants, EdibleAmino Acid SequenceAmino AcidsMolecular Sequence DataCoenzymesAnemia, SideroblasticSkin CreamErythrocytesDimercaprol4-Aminobutyrate TransaminaseDialysisAminooxyacetic AcidCatalysisProtein BindingTyrosine TransaminaseChemistryBoratesChemical PhenomenaPQQ CofactorGlyceraldehyde 3-PhosphateThreonine DehydrataseInositol PhosphatesHydroxylaminesLiverMagnetic Resonance SpectroscopyTransferasesMolecular WeightProtein ConformationAlanine TransaminaseAdenosine TriphosphateSerineSpectrometry, FluorescenceChromatography, High Pressure LiquidGlucosephosphate DehydrogenaseSwineSickle Cell TraitSpectrum AnalysisPentose Phosphate PathwayCysteineOrnithineAdenosine MonophosphateCytosine NucleotidesPicolinesOrnithine DecarboxylaseGlycineModels, MolecularDihydroxyacetone PhosphateVitamin B ComplexElectrophoresis, Polyacrylamide GelGlucosephosphatesCyanidesPhosphate Transport ProteinsCircular Dichroism
Pyridoxal Phosphate
This is the active form of VITAMIN B 6 serving as a coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, aminolevulinic acid. During transamination of amino acids, pyridoxal phosphate is transiently converted into pyridoxamine phosphate (PYRIDOXAMINE).
Pyridoxal
The 4-carboxyaldehyde form of VITAMIN B 6 which is converted to PYRIDOXAL PHOSPHATE which is a coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, aminolevulinic acid.
Pyridoxal Kinase
An enzyme that catalyzes reversibly the phosphorylation of pyridoxal in the presence of ATP with the formation of pyridoxal 5-phosphate and ADP. Pyridoxine, pyridoxamine and various derivatives can also act as acceptors. EC 2.7.1.35.
Pyridoxine
The 4-methanol form of VITAMIN B 6 which is converted to PYRIDOXAL PHOSPHATE which is a coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, aminolevulinic acid. Although pyridoxine and Vitamin B 6 are still frequently used as synonyms, especially by medical researchers, this practice is erroneous and sometimes misleading (EE Snell; Ann NY Acad Sci, vol 585 pg 1, 1990).
Pyridoxamine
The 4-aminomethyl form of VITAMIN B 6. During transamination of amino acids, PYRIDOXAL PHOSPHATE is transiently converted into pyridoxamine phosphate.
Phosphates
Inorganic salts of phosphoric acid.
Vitamin B 6 Deficiency
A nutritional condition produced by a deficiency of VITAMIN B 6 in the diet, characterized by dermatitis, glossitis, cheilosis, and stomatitis. Marked deficiency causes irritability, weakness, depression, dizziness, peripheral neuropathy, and seizures. In infants and children typical manifestations are diarrhea, anemia, and seizures. Deficiency can be caused by certain medications, such as isoniazid.
Borohydrides
A class of inorganic or organic compounds that contain the borohydride (BH4-) anion.
Transaminases
A subclass of enzymes of the transferase class that catalyze the transfer of an amino group from a donor (generally an amino acid) to an acceptor (generally a 2-keto acid). Most of these enzymes are pyridoxyl phosphate proteins. (Dorland, 28th ed) EC 2.6.1.
Tryptophan Synthase
An enzyme that catalyzes the conversion of L-serine and 1-(indol-3-yl)glycerol 3-phosphate to L-tryptophan and glyceraldehyde 3-phosphate. It is a pyridoxal phosphate protein that also catalyzes the conversion of serine and indole into tryptophan and water and of indoleglycerol phosphate into indole and glyceraldehyde phosphate. (From Enzyme Nomenclature, 1992) EC 4.2.1.20.
Aspartate Aminotransferases
Enzymes of the transferase class that catalyze the conversion of L-aspartate and 2-ketoglutarate to oxaloacetate and L-glutamate. EC 2.6.1.1.
Apoenzymes
The protein components of enzyme complexes (HOLOENZYMES). An apoenzyme is the holoenzyme minus any cofactors (ENZYME COFACTORS) or prosthetic groups required for the enzymatic function.
Pyridoxaminephosphate Oxidase
An enzyme catalyzing the deamination of pyridoxaminephosphate to pyridoxal phosphate. It is a flavoprotein that also oxidizes pyridoxine-5-phosphate and pyridoxine. EC 1.4.3.5.
Vitamin B 6
VITAMIN B 6 refers to several PICOLINES (especially PYRIDOXINE; PYRIDOXAL; & PYRIDOXAMINE) that are efficiently converted by the body to PYRIDOXAL PHOSPHATE which is a coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, and aminolevulinic acid. During transamination of amino acids, pyridoxal phosphate is transiently converted into PYRIDOXAMINE phosphate. Although pyridoxine and Vitamin B 6 are still frequently used as synonyms, especially by medical researchers, this practice is erroneous and sometimes misleading (EE Snell; Ann NY Acad Sci, vol 585 pg 1, 1990). Most of vitamin B6 is eventually degraded to PYRIDOXIC ACID and excreted in the urine.
Lyases
A class of enzymes that catalyze the cleavage of C-C, C-O, and C-N, and other bonds by other means than by hydrolysis or oxidation. (Enzyme Nomenclature, 1992) EC 4.
Kinetics
The rate dynamics in chemical or physical systems.
Glycine Hydroxymethyltransferase
A pyridoxal phosphate enzyme that catalyzes the reaction of glycine and 5,10-methylene-tetrahydrofolate to form serine. It also catalyzes the reaction of glycine with acetaldehyde to form L-threonine. EC 2.1.2.1.
Schiff Bases
Condensation products of aromatic amines and aldehydes forming azomethines substituted on the N atom, containing the general formula R-N:CHR. (From Grant & Hackh's Chemical Dictionary, 5th ed)
Phosphorylases
A class of glucosyltransferases that catalyzes the degradation of storage polysaccharides, such as glucose polymers, by phosphorolysis in animals (GLYCOGEN PHOSPHORYLASE) and in plants (STARCH PHOSPHORYLASE).
D-Alanine Transaminase
A PYRIDOXAL PHOSPHATE containing enzyme that catalyzes the reversible transfer of an amino group between D-Alanine and alpha-ketoglutarate to form PYRUVATE and D-GLUTAMATE, respectively. It plays a role in the synthesis of the bacterial CELL WALL. This enzyme was formerly classified as EC 2.6.1.10.
Pyridoxic Acid
The catabolic product of most of VITAMIN B 6; (PYRIDOXINE; PYRIDOXAL; and PYRIDOXAMINE) which is excreted in the urine.
L-Serine Dehydratase
A PYRIDOXAL-phosphate containing enzyme that catalyzes the dehydration and deamination of L-serine to form pyruvate. This enzyme was formerly listed as EC 4.2.1.13.
Tyrosine Phenol-Lyase
An enzyme that catalyzes the cleavage of tyrosine to phenol, pyruvate, and ammonia. It is a pyridoxal phosphate protein. The enzyme also forms pyruvate from D-tyrosine, L-cysteine, S-methyl-L-cysteine, L-serine, and D-serine, although at a slower rate. EC 4.1.99.2.
Spectrophotometry
The art or process of comparing photometrically the relative intensities of the light in different parts of the spectrum.
Carboxy-Lyases
Enzymes that catalyze the addition of a carboxyl group to a compound (carboxylases) or the removal of a carboxyl group from a compound (decarboxylases). EC 4.1.1.
Ornithine-Oxo-Acid Transaminase
A pyridoxal phosphate enzyme that catalyzes the formation of glutamate gamma-semialdehyde and an L-amino acid from L-ornithine and a 2-keto-acid. EC 2.6.1.13.
Binding Sites
The parts of a macromolecule that directly participate in its specific combination with another molecule.
Semicarbazides
Imines
Escherichia coli
A species of gram-negative, facultatively anaerobic, rod-shaped bacteria (GRAM-NEGATIVE FACULTATIVELY ANAEROBIC RODS) commonly found in the lower part of the intestine of warm-blooded animals. It is usually nonpathogenic, but some strains are known to produce DIARRHEA and pyogenic infections. Pathogenic strains (virotypes) are classified by their specific pathogenic mechanisms such as toxins (ENTEROTOXIGENIC ESCHERICHIA COLI), etc.
Calcium Phosphates
Calcium salts of phosphoric acid. These compounds are frequently used as calcium supplements.
Spectrophotometry, Ultraviolet
Determination of the spectra of ultraviolet absorption by specific molecules in gases or liquids, for example Cl2, SO2, NO2, CS2, ozone, mercury vapor, and various unsaturated compounds. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
Tyrosine Decarboxylase
A pyridoxal-phosphate protein that catalyzes the conversion of L-tyrosine to tyramine and carbon dioxide. The bacterial enzyme also acts on 3-hydroxytyrosine and, more slowly, on 3-hydroxyphenylalanine. (From Enzyme Nomenclature, 1992) EC 4.1.1.25.
Hydrogen-Ion Concentration
The normality of a solution with respect to HYDROGEN ions; H+. It is related to acidity measurements in most cases by pH = log 1/2[1/(H+)], where (H+) is the hydrogen ion concentration in gram equivalents per liter of solution. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)
Glucose-6-Phosphate
An ester of glucose with phosphoric acid, made in the course of glucose metabolism by mammalian and other cells. It is a normal constituent of resting muscle and probably is in constant equilibrium with fructose-6-phosphate. (Stedman, 26th ed)
Glyceraldehyde-3-Phosphate Dehydrogenases
Enzymes that catalyze the dehydrogenation of GLYCERALDEHYDE 3-PHOSPHATE. Several types of glyceraldehyde-3-phosphate-dehydrogenase exist including phosphorylating and non-phosphorylating varieties and ones that transfer hydrogen to NADP and ones that transfer hydrogen to NAD.
Aldehydes
Organic compounds containing a carbonyl group in the form -CHO.
Sugar Phosphates
Hemoglobin C Disease
A disease characterized by compensated hemolysis with a normal hemoglobin level or a mild to moderate anemia. There may be intermittent abdominal discomfort, splenomegaly, and slight jaundice.
Tryptophanase
An enzyme that catalyzes the conversion of L-tryptophan and water to indole, pyruvate, and ammonia. It is a pyridoxal-phosphate protein, requiring K+. It also catalyzes 2,3-elimination and beta-replacement reactions of some indole-substituted tryptophan analogs of L-cysteine, L-serine, and other 3-substituted amino acids. (From Enzyme Nomenclature, 1992) EC 4.1.99.1.
Lysine
An essential amino acid. It is often added to animal feed.
Phosphorylase b
The inactive form of GLYCOGEN PHOSPHORYLASE that is converted to the active form PHOSPHORYLASE A via phosphorylation by PHOSPHORYLASE KINASE and ATP.
Pimelic Acids
A group of compounds that are derivatives of heptanedioic acid with the general formula R-C7H11O4.
Cysteine Synthase
An enzyme that catalyzes the biosynthesis of cysteine in microorganisms and plants from O-acetyl-L-serine and hydrogen sulfide. This enzyme was formerly listed as EC 4.2.99.8.
Cystathionine beta-Synthase
A multifunctional pyridoxal phosphate enzyme. In the second stage of cysteine biosynthesis it catalyzes the reaction of homocysteine with serine to form cystathionine with the elimination of water. Deficiency of this enzyme leads to HYPERHOMOCYSTEINEMIA and HOMOCYSTINURIA. EC 4.2.1.22.
Substrate Specificity
A characteristic feature of enzyme activity in relation to the kind of substrate on which the enzyme or catalytic molecule reacts.
5-Aminolevulinate Synthetase
An enzyme of the transferase class that catalyzes condensation of the succinyl group from succinyl coenzyme A with glycine to form delta-aminolevulinate. It is a pyridoxyal phosphate protein and the reaction occurs in mitochondria as the first step of the heme biosynthetic pathway. The enzyme is a key regulatory enzyme in heme biosynthesis. In liver feedback is inhibited by heme. EC 2.3.1.37.
Plants, Edible
An organism of the vegetable kingdom suitable by nature for use as a food, especially by human beings. Not all parts of any given plant are edible but all parts of edible plants have been known to figure as raw or cooked food: leaves, roots, tubers, stems, seeds, buds, fruits, and flowers. The most commonly edible parts of plants are FRUIT, usually sweet, fleshy, and succulent. Most edible plants are commonly cultivated for their nutritional value and are referred to as VEGETABLES.
Amino Acid Sequence
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
Amino Acids
Organic compounds that generally contain an amino (-NH2) and a carboxyl (-COOH) group. Twenty alpha-amino acids are the subunits which are polymerized to form proteins.
Molecular Sequence Data
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Coenzymes
Small molecules that are required for the catalytic function of ENZYMES. Many VITAMINS are coenzymes.
Anemia, Sideroblastic
Anemia characterized by the presence of erythroblasts containing excessive deposits of iron in the marrow.
Skin Cream
A water-soluble medicinal preparation applied to the skin.
Erythrocytes
Red blood cells. Mature erythrocytes are non-nucleated, biconcave disks containing HEMOGLOBIN whose function is to transport OXYGEN.
Dimercaprol
An anti-gas warfare agent that is effective against Lewisite (dichloro(2-chlorovinyl)arsine) and formerly known as British Anti-Lewisite or BAL. It acts as a chelating agent and is used in the treatment of arsenic, gold, and other heavy metal poisoning.
4-Aminobutyrate Transaminase
An enzyme that converts brain gamma-aminobutyric acid (GAMMA-AMINOBUTYRIC ACID) into succinate semialdehyde, which can be converted to succinic acid and enter the citric acid cycle. It also acts on beta-alanine. EC 2.6.1.19.
Dialysis
A process of selective diffusion through a membrane. It is usually used to separate low-molecular-weight solutes which diffuse through the membrane from the colloidal and high-molecular-weight solutes which do not. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
Aminooxyacetic Acid
A compound that inhibits aminobutyrate aminotransferase activity in vivo, thereby raising the level of gamma-aminobutyric acid in tissues.
Catalysis
The facilitation of a chemical reaction by material (catalyst) that is not consumed by the reaction.
Protein Binding
The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments.
Tyrosine Transaminase
An enzyme that catalyzes the conversion of L-TYROSINE and 2-oxoglutarate to 4-hydroxyphenylpyruvate and L-GLUTAMATE. It is a pyridoxal-phosphate protein. L-PHENYLALANINE is hydroxylated to L-tyrosine. The mitochondrial enzyme may be identical with ASPARTATE AMINOTRANSFERASES (EC 2.6.1.1.). Deficiency of this enzyme may cause type II Tyrosinemia (see TYROSINEMIAS). EC 2.6.1.5.
Chemistry
A basic science concerned with the composition, structure, and properties of matter; and the reactions that occur between substances and the associated energy exchange.
Borates
Inorganic or organic salts and esters of boric acid.
Chemical Phenomena
The composition, conformation, and properties of atoms and molecules, and their reaction and interaction processes.
PQQ Cofactor
A pyrrolo-quinoline having two adjacent keto-groups at the 4 and 5 positions and three acidic carboxyl groups. It is a coenzyme of some DEHYDROGENASES.
Glyceraldehyde 3-Phosphate
An aldotriose which is an important intermediate in glycolysis and in tryptophan biosynthesis.
Threonine Dehydratase
A pyridoxal-phosphate protein that catalyzes the deamination of THREONINE to 2-ketobutyrate and AMMONIA. The role of this enzyme can be biosynthetic or biodegradative. In the former role it supplies 2-ketobutyrate required for ISOLEUCINE biosynthesis, while in the latter it is only involved in the breakdown of threonine to supply energy. This enzyme was formerly listed as EC 4.2.1.16.
Inositol Phosphates
Phosphoric acid esters of inositol. They include mono- and polyphosphoric acid esters, with the exception of inositol hexaphosphate which is PHYTIC ACID.
Hydroxylamines
Organic compounds that contain the (-NH2OH) radical.
Liver
A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.
Magnetic Resonance Spectroscopy
Spectroscopic method of measuring the magnetic moment of elementary particles such as atomic nuclei, protons or electrons. It is employed in clinical applications such as NMR Tomography (MAGNETIC RESONANCE IMAGING).
Transferases
Transferases are enzymes transferring a group, for example, the methyl group or a glycosyl group, from one compound (generally regarded as donor) to another compound (generally regarded as acceptor). The classification is based on the scheme "donor:acceptor group transferase". (Enzyme Nomenclature, 1992) EC 2.
Molecular Weight
The sum of the weight of all the atoms in a molecule.
Protein Conformation
The characteristic 3-dimensional shape of a protein, including the secondary, supersecondary (motifs), tertiary (domains) and quaternary structure of the peptide chain. PROTEIN STRUCTURE, QUATERNARY describes the conformation assumed by multimeric proteins (aggregates of more than one polypeptide chain).
Alanine Transaminase
An enzyme that catalyzes the conversion of L-alanine and 2-oxoglutarate to pyruvate and L-glutamate. (From Enzyme Nomenclature, 1992) EC 2.6.1.2.
Adenosine Triphosphate
An adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter.
Serine
A non-essential amino acid occurring in natural form as the L-isomer. It is synthesized from GLYCINE or THREONINE. It is involved in the biosynthesis of PURINES; PYRIMIDINES; and other amino acids.
Spectrometry, Fluorescence
Measurement of the intensity and quality of fluorescence.
Chromatography, High Pressure Liquid
Liquid chromatographic techniques which feature high inlet pressures, high sensitivity, and high speed.
Glucosephosphate Dehydrogenase
Swine
Any of various animals that constitute the family Suidae and comprise stout-bodied, short-legged omnivorous mammals with thick skin, usually covered with coarse bristles, a rather long mobile snout, and small tail. Included are the genera Babyrousa, Phacochoerus (wart hogs), and Sus, the latter containing the domestic pig (see SUS SCROFA).
Sickle Cell Trait
The condition of being heterozygous for hemoglobin S.
Spectrum Analysis
The measurement of the amplitude of the components of a complex waveform throughout the frequency range of the waveform. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)
Pentose Phosphate Pathway
An oxidative decarboxylation process that converts GLUCOSE-6-PHOSPHATE to D-ribose-5-phosphate via 6-phosphogluconate. The pentose product is used in the biosynthesis of NUCLEIC ACIDS. The generated energy is stored in the form of NADPH. This pathway is prominent in tissues which are active in the synthesis of FATTY ACIDS and STEROIDS.
Cysteine
A thiol-containing non-essential amino acid that is oxidized to form CYSTINE.
Ornithine
An amino acid produced in the urea cycle by the splitting off of urea from arginine.
Adenosine Monophosphate
Adenine nucleotide containing one phosphate group esterified to the sugar moiety in the 2'-, 3'-, or 5'-position.
Cytosine Nucleotides
Picolines
A group of compounds that are monomethyl derivatives of pyridines. (From Dorland, 28th ed)
Ornithine Decarboxylase
A pyridoxal-phosphate protein, believed to be the rate-limiting compound in the biosynthesis of polyamines. It catalyzes the decarboxylation of ornithine to form putrescine, which is then linked to a propylamine moiety of decarboxylated S-adenosylmethionine to form spermidine.
Glycine
A non-essential amino acid. It is found primarily in gelatin and silk fibroin and used therapeutically as a nutrient. It is also a fast inhibitory neurotransmitter.
Models, Molecular
Models used experimentally or theoretically to study molecular shape, electronic properties, or interactions; includes analogous molecules, computer-generated graphics, and mechanical structures.
Dihydroxyacetone Phosphate
An important intermediate in lipid biosynthesis and in glycolysis.
Vitamin B Complex
A group of water-soluble vitamins, some of which are COENZYMES.
Electrophoresis, Polyacrylamide Gel
Electrophoresis in which a polyacrylamide gel is used as the diffusion medium.
Glucosephosphates
Cyanides
Inorganic salts of HYDROGEN CYANIDE containing the -CN radical. The concept also includes isocyanides. It is distinguished from NITRILES, which denotes organic compounds containing the -CN radical.
Phosphate Transport Proteins
Membrane proteins that are involved in the active transport of phosphate.
Circular Dichroism
A change from planar to elliptic polarization when an initially plane-polarized light wave traverses an optically active medium. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
Stereoisomerism
The phenomenon whereby compounds whose molecules have the same number and kind of atoms and the same atomic arrangement, but differ in their spatial relationships. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)
Histidine
An essential amino acid that is required for the production of HISTAMINE.
Macromolecular Substances
Compounds and molecular complexes that consist of very large numbers of atoms and are generally over 500 kDa in size. In biological systems macromolecular substances usually can be visualized using ELECTRON MICROSCOPY and are distinguished from ORGANELLES by the lack of a membrane structure.
Homocysteine
A thiol-containing amino acid formed by a demethylation of METHIONINE.
Purinergic P2 Receptor Antagonists
Compounds that bind to and block the stimulation of PURINERGIC P2 RECEPTORS.
Glucose-6-Phosphate Isomerase
An aldose-ketose isomerase that catalyzes the reversible interconversion of glucose 6-phosphate and fructose 6-phosphate. In prokaryotic and eukaryotic organisms it plays an essential role in glycolytic and gluconeogenic pathways. In mammalian systems the enzyme is found in the cytoplasm and as a secreted protein. This secreted form of glucose-6-phosphate isomerase has been referred to as autocrine motility factor or neuroleukin, and acts as a cytokine which binds to the AUTOCRINE MOTILITY FACTOR RECEPTOR. Deficiency of the enzyme in humans is an autosomal recessive trait, which results in CONGENITAL NONSPHEROCYTIC HEMOLYTIC ANEMIA.
Mutation
Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.
Tryptophan
An essential amino acid that is necessary for normal growth in infants and for NITROGEN balance in adults. It is a precursor of INDOLE ALKALOIDS in plants. It is a precursor of SEROTONIN (hence its use as an antidepressant and sleep aid). It can be a precursor to NIACIN, albeit inefficiently, in mammals.
Ribosemonophosphates
Ribose substituted in the 1-, 3-, or 5-position by a phosphoric acid moiety.
Base Sequence
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
Alanine
A non-essential amino acid that occurs in high levels in its free state in plasma. It is produced from pyruvate by transamination. It is involved in sugar and acid metabolism, increases IMMUNITY, and provides energy for muscle tissue, BRAIN, and the CENTRAL NERVOUS SYSTEM.
Recombinant Proteins
Proteins prepared by recombinant DNA technology.
Sulfhydryl Reagents
Chemical agents that react with SH groups. This is a chemically diverse group that is used for a variety of purposes. Among these are enzyme inhibition, enzyme reactivation or protection, and labelling.
Chromatography
Techniques used to separate mixtures of substances based on differences in the relative affinities of the substances for mobile and stationary phases. A mobile phase (fluid or gas) passes through a column containing a stationary phase of porous solid or liquid coated on a solid support. Usage is both analytical for small amounts and preparative for bulk amounts.
Structure-Activity Relationship
The relationship between the chemical structure of a compound and its biological or pharmacological activity. Compounds are often classed together because they have structural characteristics in common including shape, size, stereochemical arrangement, and distribution of functional groups.
Cloning, Molecular
The insertion of recombinant DNA molecules from prokaryotic and/or eukaryotic sources into a replicating vehicle, such as a plasmid or virus vector, and the introduction of the resultant hybrid molecules into recipient cells without altering the viability of those cells.

Update on interconversions of vitamin B-6 with its coenzyme. (1/1448)

Biosynthesis of pyridoxal 5'-phosphate (PLP) depends upon the relatively specific action of two consecutive enzymes, viz. pyridoxal (pyridoxine, pyridoxamine) kinase and pyridoxine (pyridoxamine) phosphate oxidase. Less specific phosphatases catalyze hydrolyses of the 5'-phosphates of the vitamers pyridoxal, pyridoxamine, and pyridoxine. From the recognition a generation ago of these processes by which the three forms of vitamin B-6 and their 5'-phosphates are interconverted, more recent studies have provided a fairly sophisticated understanding of the molecular characteristics of the enzymes involved. The evolutionary retention of homologous portions of pyridoxal kinase in humans as well as bacteria and the most recent finding of a highly conserved region of the pyridoxine (pyridoxamine) phosphate oxidase, also from both prokaryotic and eukaryotic organisms, emphasize the importance of these catalysts in the formation of a coenzyme that is essential for most organisms. Both kinase and oxidase involved in B-6 metabolism are potential targets for pharmacologic agents.  (+info)

Reaction specificity of native and nicked 3,4-dihydroxyphenylalanine decarboxylase. (2/1448)

3,4-Dihydroxyphenylalanine (Dopa) decarboxylase is a stereospecific pyridoxal 5'-phosphate (PLP)-dependent alpha-decarboxylase that converts L-aromatic amino acids into their corresponding amines. We now report that reaction of the enzyme with D-5-hydroxytryptophan or D-Dopa results in a time-dependent inactivation and conversion of the PLP coenzyme to pyridoxamine 5'-phosphate and PLP-D-amino acid Pictet-Spengler adducts, which have been identified by high performance liquid chromatography. We also show that the reaction specificity of Dopa decarboxylase toward aromatic amines depends on the experimental conditions. Whereas oxidative deamination occurs under aerobic conditions (Bertoldi, M., Moore, P. S., Maras, B., Dominici, P., and Borri Voltattorni, C. (1996) J. Biol. Chem. 271, 23954-23959; Bertoldi, M., Dominici, P., Moore, P. S., Maras, B., and Borri Voltattorni, C. (1998) Biochemistry 37, 6552-6561), half-transamination and Pictet-Spengler reactions take place under anaerobic conditions. Moreover, we examined the reaction specificity of nicked Dopa decarboxylase, obtained by selective tryptic cleavage of the native enzyme between Lys334 and His335. Although this enzymatic species does not exhibit either decarboxylase or oxidative deamination activities, it retains a large percentage of the native transaminase activity toward D-aromatic amino acids and displays a slow transaminase activity toward aromatic amines. These transamination reactions occur concomitantly with the formation of cyclic coenzyme-substrate adducts. Together with additional data, we thus suggest that native Dopa decarboxylase can exist as an equilibrium among "open," "half-open," and "closed" forms.  (+info)

Carbon 13 NMR study of nonenzymatic reactions of pyridoxal 5'-phosphate with selected amino acids and of related reactions. (3/1448)

Carbon 13 nuclear magnetic resonance spectroscopy has been used to monitor the nonenzymatic reactions of pyridoxal 5'-phosphate with glycine, alanine, valine, serine, and with several other model compounds. Isotopically enriched amino acids were employed so that low concentrations could be utilized while still allowing relatively rapid acquisition of spectral data. The results for alanine and serine are particularly noteworthy in that alanine is deaminated to pyruvate and pyruvate is aminated to alanine, but contrary to the enzymatic reactions of various serine dehydratases wherein serine is converted to pyruvate, the nonenzymatic reaction utilizing serine results in hydroxypruvate rather than pyruvate formation. In the reverse reaction, hydroxypyruvate is aminated to serine but very inefficiently relative to the amination of pyruvate to alanine. The experimental results have been formulated into a proposed reaction mechanism for deamination of amino acids by pyridoxal-P.  (+info)

A prospective study on folate, B12, and pyridoxal 5'-phosphate (B6) and breast cancer. (4/1448)

To investigate the incidence of breast cancer and prediagnostic serum levels of folate, B12, and pyridoxal 5'-phosphate (B6), we conducted a nested case-control study using resources from the Washington County (Maryland) serum bank. In 1974, 12,450 serum specimens were donated, and in 1989, 14,625 plasma specimens were donated by female residents of Washington County. One hundred ninety-five incident breast cancer cases and 195 controls were matched by age, race, menopausal status at donation, and cohort participation as well as by date of blood donation. In both cohorts and all menopausal subgroups, median B12 concentrations were lower among cases than controls. Differences reached statistical significance only among women who were postmenopausal at donation (1974 cohort, 413 versus 482 pg/ml, P = 0.03; 1989 cohort, 406 versus 452 pg/ml, P = 0.02). Among women postmenopausal at blood donation, observed associations of B12 suggested a threshold effect with increased risk of breast cancer in the lowest one-fifth compared to the higher four-fifths of the control distribution [lowest versus highest fifth: 1974 cohort, matched odds ratio = 4.00 (95% confidence interval = 1.05-15.20); 1989 cohort, matched odds ratio = 2.25 (95% confidence interval = 0.86-5.91)]. We found no evidence for an association between folate, B6, and homocysteine and breast cancer. Findings suggested a threshold effect for serum B12 with an increased risk of breast cancer among postmenopausal women in the lowest one-fifth compared to the higher four-fifths of the control distribution. These results should stimulate further investigations of potentially modifiable risk factors, such as these B-vitamins, for prevention of breast cancer.  (+info)

Serine transhydroxymethylase from rabbit liver. Sequence of anonapeptide at the pyridoxal-5'-phosphate-binding site. (5/1448)

The amino acid sequence of the coenzyme-binding site of serine transhydroxymethylase from rabbit liver has been determined. After reduction with NaBH4 and aminoethylation, a first sample of enzyme was digested with thermolysin and a single phosphopyridoxyl peptide was isolated. A second sample of similarly treated enzyme was digested with chymotrypsin and three phosphopyridoxyl peptides clearly originating from a unique coenzyme-binding site were isolated. Sequence analysis of these peptides indicate the following structure: Val-Val-Thr-Thr-His(Pxy)-Thr-Leu. Sequence homologies of the active site of various pyridoxalphosphate enzymes are discussed in terms of a possible catalytic role and of evolution of this class of proteins.  (+info)

Effects of vasopressin on the sympathetic contraction of rabbit ear artery during cooling. (6/1448)

In order to analyse the effects of arginine-vasopressin on the vascular contraction to sympathetic nerve stimulation during cooling, the isometric response of isolated, 2-mm segments of the rabbit central ear (cutaneous) artery to electrical field stimulation (1-8 Hz) was recorded at 37 and 30 degrees C. Electrical stimulation (37 degrees C) produced frequency-dependent arterial contraction, which was reduced at 30 degrees C and potentiated by vasopressin (10 pM, 100 pM and 1 nM). This potentiation was greater at 30 than at 37 degrees C and was abolished at both temperatures by the antagonist of vasopressin V1 receptors d(CH2)5 Tyr(Me)AVP (100 nM). Desmopressin (1 microM) did not affect the response to electrical stimulation. At 37 degrees C, the vasopressin-induced potentiation was abolished by the purinoceptor antagonist PPADS (30 microM), increased by phentolamine (1 microM) or prazosin (1 microM) and not modified by yohimbine (1 microM), whilst at 30 degrees C, the potentiation was reduced by phentolamine, yohimbine or PPADS, and was not modified by prazosin. The Ca2+-channel blockers, verapamil (10 microM) and NiCl2 (1 mM), abolished the potentiating effects of vasopressin at 37 degrees C whilst verapamil reduced and NiCl2 abolished this potentiation at 30 degrees C. The inhibitor of nitric oxide synthesis, L-NOARG (100 microM), or endothelium removal did not modify the potentiation by vasopressin at 37 and 30 degrees C. Vasopressin also increased the arterial contraction to the alpha2-adrenoceptor agonist BHT-920 (10 microM) and to ATP (2 mM) at 30 and 37 degrees C, but it did not modify the contraction to noradrenaline (1 microM) at either temperature. These results suggest that in cutaneous (ear) arteries, vasopressin potentiaties sympathetic vasoconstriction to a greater extent at 30 than at 37 degrees C by activating vasopressin V1 receptors and Ca2+ channels at both temperatures. At 37 degrees C, the potentiation appears related to activation of the purinoceptor component and, at 30 degrees C, to activation of both purinoceptor and alpha2-adrenoceptor components of the sympathetic response.  (+info)

Rat liver serine dehydratase. Bacterial expression and two folding domains as revealed by limited proteolysis. (7/1448)

A pCW vector harboring rat liver serine dehydratase cDNA was expressed in Escherichia coli. The expressed level was about 5-fold higher in E. coli BL21 than in JM109 cell extract; the former lacked two kinds of proteases. Immunoblot analysis revealed the occurrence of a derivative other than serine dehydratase in the JM109 cell extract. The recombinant enzyme was purified to homogeneity. Staphylococcus aureus V8 protease and trypsin cleaved the enzyme at Glu-206 and Lys-220, respectively, with a concomitant loss of enzyme activity. Spectrophotometrically, the nicked enzyme showed a approximately 50% reduced capacity for binding of the coenzyme pyridoxal phosphate and no spectral change of circular dichroism in the region at 300-480 nm, whereas circular dichroism spectra of both enzymes in the far-UV region were similar, suggesting that proteolysis impairs the coenzyme binding without an accompanying gross change of the secondary structure. Whereas the nicked enzyme behaved like the intact enzyme on Sephadex G-75 column chromatography, it was dissociated into two fragments on the column containing 6 M urea. Upon the removal of urea, both fragments spontaneously refolded. These results suggest that serine dehydratase consists of two folding domains connected by a region that is very susceptible to proteases.  (+info)

Chemical modification of NADP-isocitrate dehydrogenase from Cephalosporium acremonium evidence of essential histidine and lysine groups at the active site. (8/1448)

NADP-isocitrate dehydrogenase from Cephalosporium acremonium CW-19 has been inactivated by diethyl pyrocarbonate following a first-order process giving a second-order rate constant of 3.0 m-1. s-1 at pH 6.5 and 25 degrees C. The pH-inactivation rate data indicated the participation of a group with a pK value of 6.9. Quantifying the increase in absorbance at 240 nm showed that six histidine residues per subunit were modified during total inactivation, only one of which was essential for catalysis, and substrate protection analysis would seem to indicate its location at the substrate binding site. The enzyme was not inactivated by 5, 5'-dithiobis(2-nitrobenzoate), N-ethylmaleimide or iodoacetate, which would point to the absence of an essential reactive cysteine residue at the active site. Pyridoxal 5'-phosphate reversibly inactivated the enzyme at pH 7.7 and 5 degrees C, with enzyme activity declining to an equilibrium value within 15 min. The remaining activity depended on the modifier concentration up to about 2 mm. The kinetic analysis of inactivation and reactivation rate data is consistent with a reversible two-step inactivation mechanism with formation of a noncovalent enzyme-pyridoxal 5'-phosphate complex prior to Schiff base formation with a probable lysyl residue of the enzyme. The analysis of substrate protection shows the essential residue(s) to be at the active site of the enzyme and probably to be involved in catalysis.  (+info)

Pyridoxal Phosphate Ying An - Drugs.comPyridoxal Phosphate Ying An - Drugs.com
Pyridoxal Phosphate Ying An is a medicine available in a number of countries worldwide. A list of US medications equivalent to Pyridoxal Phosphate Ying An is available on the Drugs.com website.
https://www.drugs.com/international/pyridoxal-phosphate-ying-an.html
Studies on the changes in protein fluorescence and enzymic activity of aspartate aminotransferase on binding of pyridoxal 5′...Studies on the changes in protein fluorescence and enzymic activity of aspartate aminotransferase on binding of pyridoxal 5′...
1. The α and β subforms of aspartate aminotransferase were purified from pig heart. 2. The α subform contained 2mol of pyridoxal 5′-phosphate. The apo-(α subform) could be fully reactived by combination with 2mol of cofactor. 3. The protein fluorescence of the apo-(α subform) decreased non-linearly with increase in enzyme activity and concentration of bound cofactor. 4. It is concluded that the enzyme activity/mol of bound cofactor is largely independent of the number of cofactors bound to the dimer. 5. The β subform had approximately half the specific enzyme activity of the α subform, and contained an average of one active pyridoxal 5′-phosphate molecule per molecule, which could be removed by glutamate, and another inactive cofactor which could only be removed with NaOH. 6. On recombination with pyridoxal 5′-phosphate the protein fluorescence of the apo-(β subform) decreased linearly, showing that each dimeric enzyme molecule contained one active and one inactive bound cofactor. ...
http://www.biochemj.org/content/143/3/643
TIGR01437TIGR01437
This HMM describes a protein related to a number of pyridoxal phosphate-dependent enzymes, and in particular to selenocysteine synthase (SelA), which converts Ser to selenocysteine on its tRNA. While resembling SelA, this protein is found only in species that have a better candidate SelA or else lack the other genes (selB, selC, and selD) required for selenocysteine incorporation ...
http://www.jcvi.org/cgi-bin/tigrfams/HmmReportPage.cgi?acc=TIGR01437
Pyridoxal phosphate (P5P)Pyridoxal phosphate (P5P)
Low vitamin B-6 status, based on plasma concentrations of pyridoxal-5-phosphate (PLP), has been identified in inflammatory diseases, including cardiovascular disease, rheumatoid arthritis, inflammatory bowel disease, and diabetes. Our objective was to examine the association between plasma PLP and multiple markers of inflammation in a community-based cohort [n = 2229 participants (55% women, mean age 61 ± 9 y)]. We created an overall inflammation score (IS) as the sum of standardized values of 13 individual inflammatory markers. Multivariable-adjusted regression analysis was used to assess the associations between the IS and plasma PLP. Geometric mean plasma PLP concentrations were lower in the highest tertile category of IS relative to the lowest (61 vs. 80 nmol/L; P-trend , 0.0001). Similarly, the prevalence of PLP insufficiency was significantly higher for participants in the highest compared with the lowest tertiles for IS categories. These relationships persisted after accounting for ...
http://flipper.diff.org/apprulesitems/pathways/info/7351
HOGENOMDNA: ASFUM1 6.PE19
ASFUM1_6.PE19 Location/Qualifiers FT CDS_pept join(84596..84927,84989..85706) FT /codon_start=1 FT /gene_family=HOG000214639 [ FAMILY / ALN / TREE ] FT /evidence=3: Inferred from homology FT /gene_id=IGI19902575 FT /orf_name=AFUA_6G00290 FT /product=Aminotransferase, putative FT /EC_number=2.6.1.1 FT /function=1-aminocyclopropane-1-carboxylate synthase FT activity FT /function=L-aspartate:2-oxoglutarate aminotransferase FT activity FT /function=pyridoxal phosphate binding FT /protein_id=EAL84236.1 FT /db_xref=GO:0004069 FT /db_xref=GO:0016847 FT /db_xref=GO:0030170 FT /db_xref=HOGENOM:HBG416157 FT /db_xref=HOGENOM:HBG685856 FT /db_xref=InterPro:IPR001176 FT /db_xref=InterPro:IPR004838 FT /db_xref=InterPro:IPR004839 FT /db_xref=InterPro:IPR015421 FT /db_xref=InterPro:IPR015422 FT /db_xref=InterPro:IPR015424 FT /db_xref=UniParc:UPI000051E68E FT /db_xref=UniProtKB/TrEMBL:Q4W8Y3 FT /transl_table=1 FT ...
http://pbil.univ-lyon1.fr/cgi-bin/acnuc-search-id?query=ASFUM1_6.PE19&db=HOGENOMDNA&ident=ACNUC7421
Domain combinations for gap ,81296, gap superfamilies in Saccharomyces cerevisiae AWRI796Domain combinations for gap ,81296, gap superfamilies in Saccharomyces cerevisiae AWRI796
Domain architectures containing the following SCOP superfamilies _gap_,81296,_gap_ in Saccharomyces cerevisiae AWRI796. Domain architectures illustrate each occurrence of _gap_,81296,_gap_.
http://supfam.mrc-lmb.cam.ac.uk/SUPERFAMILY/cgi-bin/allcombs.cgi?genome=Sb
GADL1 (glutamate decarboxylase like 1) - Chinchilla Research Resource Database
ENCODES a protein that exhibits carboxy-lyase activity (inferred); pyridoxal phosphate binding (inferred); INVOLVED IN carboxylic acid metabolic process (inferred); ASSOCIATED WITH amenorrhea (ortholog); Liver Neoplasms (ortholog)
https://crrd.mcw.edu/rgdweb/report/gene/main.html?id=12361244
Noncoded amino acid replacement probes of the aspartate aminotransferase mechanismNoncoded amino acid replacement probes of the aspartate aminotransferase mechanism
The primary role of Tyr225 in the aspartate aminotransferase mechanism is to provide a hydrogen bond to stabilize the 3O- functionality of bound pyridoxal phosphate. The strength of this hydrogen bond is perturbed by replacement of Tyr225 with 3-fluoro-L-tyrosine (FlTyr) by in vitro transcription/translation. This mutant enzyme exhibits kcat/values that are near to those of wild type enzyme; however, the kcat/vs pH profile is much sharper with similar pKas of approximately 7.5 for both the ascending and descending limbs. The pKas are assigned to the endocyclic proton of the internal aldimine and to the bridging hydrogen bond, respectively. The pKas in the kcat vs pH profile of 7.2 and 8.7 are assigned to the epsilon-NH3+ of lysine 258 and to the endocyclic protons of the ketimine complex, respectively. Arginine 292 forms a salt bridge with the beta-COOH of the substrate, aspartate. An improvement on the earlier attempt to invert the substrate charge specificity via R292D mutation-induced ...
https://vivo.scripps.edu/display/endnote170625
Pyridoxal 5-phosphate | 41468-25-1Pyridoxal 5-phosphate | 41468-25-1
Visit ChemicalBook To find more Pyridoxal 5-phosphate(41468-25-1) information like chemical properties,Structure,melting point,boiling point,density,molecular formula,molecular weight, physical properties,toxicity information,customs codes. You can also browse global suppliers,vendor,prices,Price,manufacturers of Pyridoxal 5-phosphate(41468-25-1). At last,Pyridoxal 5-phosphate(41468-25-1) safety, risk, hazard and MSDS, CAS,cas number,Use,cas no may also be you need.
http://www.chemicalbook.com/ChemicalProductProperty_EN_CB6757175.htm
Pyridoxal phosphate-dependent transferase, subdomain 2 (IPR015422) | InterPro | EMBL-EBIPyridoxal phosphate-dependent transferase, subdomain 2 (IPR015422) | InterPro | EMBL-EBI
InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites. We combine protein signatures from a number of member databases into a single searchable resource, capitalising on their individual strengths to produce a powerful integrated database and diagnostic tool.
https://www.ebi.ac.uk/interpro/entry/IPR015422
Diferència entre revisions de la pàgina «Cofactor enzimàtic» - Viquipèdia, lenciclopèdia lliureDiferència entre revisions de la pàgina «Cofactor enzimàtic» - Viquipèdia, lenciclopèdia lliure
Piridoxal fosfat]] ,ref,{{cite journal ,author=Eliot AC, Kirsch JF ,title=Pyridoxal phosphate enzymes: mechanistic, structural, and evolutionary considerations ,journal=Annu. Rev. Biochem. ,volume=73 ,issue= ,pages=383-415 ,year=2004 ,pmid=15189147 ,doi=10.1146/annurev.biochem.73.011303.074021}},/ref, ,, [[Piridoxina]] (B,sub,6,/sub,) ,, Cap ,, Grups amino i carboxil ,, [[Bacteris]], [[archaea]] i [[eucariotes ...
https://ca.wikipedia.org/wiki/Especial:MobileDiff/11129997
Sequence Similarity - 1AKA: STRUCTURAL BASIS FOR THE CATALYTIC ACTIVITY OF ASPARTATE AMINOTRANSFERASE K258H LACKING...Sequence Similarity - 1AKA: STRUCTURAL BASIS FOR THE CATALYTIC ACTIVITY OF ASPARTATE AMINOTRANSFERASE K258H LACKING...
1AKA: Structural basis for the catalytic activity of aspartate aminotransferase K258H lacking the pyridoxal 5-phosphate-binding lysine residue.
http://www.rcsb.org/pdb/explore/sequenceCluster.do?structureId=1AKA
Sequence Similarity - 1AIB: STRUCTURAL BASIS FOR THE CATALYTIC ACTIVITY OF ASPARTATE AMINOTRANSFERASE K258H LACKING...Sequence Similarity - 1AIB: STRUCTURAL BASIS FOR THE CATALYTIC ACTIVITY OF ASPARTATE AMINOTRANSFERASE K258H LACKING...
1AIB: Structural basis for the catalytic activity of aspartate aminotransferase K258H lacking the pyridoxal 5-phosphate-binding lysine residue.
http://www.rcsb.org/pdb/explore/sequenceCluster.do?structureId=1AIB
L-methylfolate+Methylcobalamin+Pyridoxal 5-phosphate - L-methylfolate+Methylcobalamin+Pyridoxal 5-phosphate Exporter,...L-methylfolate+Methylcobalamin+Pyridoxal 5-phosphate - L-methylfolate+Methylcobalamin+Pyridoxal 5-phosphate Exporter,...
DEWCARE CONCEPT PVT. LTD. - Exporter, Manufacturer, Distributor, Supplier, Trading Company, Wholesaler & Dealer of L-methylfolate+Methylcobalamin+Pyridoxal 5-phosphate based in Ahmedabad, India
http://www.dewcareconcept.com/l-methylfolate-methylcobalamin-pyridoxal-5-phosphate-5979408.html
Use of Chlorite to Improve HPLC Detection of Pyridoxal 5-phosphate by Karen L. Ericson, J. D. Mahuren et al.
Karen L. Ericson, J. D. Mahuren, Yvonne Zubovic, and Stephen P. Coburn (2005). Use of Chlorite to Improve HPLC Detection of Pyridoxal 5-phosphate. Journal Of Chromatography. B, Analytical Technologies In The Biomedical And Life Sciences.823 (2), 218-220 ...
http://opus.ipfw.edu/chemistry_facpubs/4/
Pyridoxal-5-Phosphate (P-5-P) Reviews on 20bestsellers.co.uk - Product Reviews on 20bestsellers.co.uk
Latest Pyridoxal-5-Phosphate (P-5-P) reviews in the category Health & Personal Care. Take a look and find your product at our test.
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Pyridoxal- 5-phosphate monohydrate | AbcamPyridoxal- 5-phosphate monohydrate | Abcam
Buy Codecarboxylase (CAS 41468-25-1), a vitamin B6 metabolite. Join researchers using high quality Codecarboxylase from Abcam and achieve your mission, faster.
http://www.abcam.com/pyridoxal-5-phosphate-monohydrate-ab146228.html
Publications | CBCBPublications | CBCB
Oberhardt MA, Zarecki R, Reshef L, Xia F, Duran-Frigola M, Schreiber R, Henry CS, Ben-Tal N, Dwyer DJ, Gophna U et al.. 2016. Systems-Wide Prediction of Enzyme Promiscuity Reveals a New Underground Alternative Route for Pyridoxal 5-Phosphate Production in E. coli.. PLoS Comput Biol. 12(1):e1004705. ...
http://cbcb.umd.edu/publications?s=year&f%5Bag%5D=R&o=desc
SAUSA300 RS12860 - AureoWikiSAUSA300 RS12860 - AureoWiki
Unknown functionEnzymes of unknown specificityPPOX class probable F420-dependent enzyme, Rv3369 family (TIGR03667; EC 1.-.-.-; HMM-score: 18.3) ...
http://aureowiki.med.uni-greifswald.de/SAUSA300_RS12860
Plus itPlus it
In this case-control study nested in the MEC study, we found an inverse association between plasma PLP levels and colorectal cancer which was not explained by an association with plasma folate, seemed stronger at low levels of alcohol intake and among individuals with the MTHFR 677TT genotype, and was independent of plasma CRP levels. An inverse association with plasma folate was also observed, which seemed to be stronger among individuals with a low level of alcohol intake and was suggested among subjects with the MTHFR 677TT genotype.. Our findings for PLP are consistent with those of Wei et al. (5) who found a 52% reduction in colorectal cancer risk comparing the highest to the lowest quartile for plasma PLP (P trend = 0.07) in a nested case-control study in women. They are also consistent with those of Figueiredo et al. (6) who found an inverse association between baseline plasma PLP levels and recurrence of adenoma in a randomized trial of aspirin and folic acid supplementation. Similarly, ...
http://cebp.aacrjournals.org/content/18/8/2195
PEGylated d-serine dehydratase as a d-serine reducing agent<...
TY - JOUR. T1 - PEGylated d-serine dehydratase as a d-serine reducing agent. AU - Ito, Tomokazu. AU - Takada, Hiroe. AU - Isobe, Keiko. AU - Suzuki, Masataka. AU - Kitaura, Yasuyuki. AU - Hemmi, Hisashi. AU - Matsuda, Tsukasa. AU - Sasabe, Jumpei. AU - Yoshimura, Tohru. PY - 2014/10/9. Y1 - 2014/10/9. N2 - D-Serine is an endogenous coagonist for N-methyl-. d-aspartate (NMDA) receptors and is involved in excitatory neurotransmission. Excessive receptor activation causes excitotoxicity, leading to various acute and chronic neurological disorders. Decrease in d-serine content may provide a therapeutic strategy for the treatment of the neurological disorders in which overstimulation of NMDA receptors plays a pathological role. Saccharomyces cerevisiae d-serine dehydratase (Dsd1p), which acts dominantly on d-serine, may be a useful d-serine reducing agent. We conjugated a linear 5-kDa polyethylene glycol (PEG) to Dsd1p (PEG-Dsd1p) and examined the effects of PEG-conjugation on its biochemical and ...
https://keio.pure.elsevier.com/en/publications/pegylated-d-serine-dehydratase-as-a-d-serine-reducing-agent-2
PubMed Kidney Transplant | Transplant Professional Portal
Background: Low plasma concentrations of pyridoxal 5-phosphate (PLP) are common in renal transplant recipients (RTRs) and confer increased risk of long-term mortality. To our knowledge, it is not known whether low plasma PLP concentrations have functional (i.e., intracellular) consequences and, if so, whether such consequences are associated with increased risk of mortality.Objectives: We assessed the association of plasma PLP with functional vitamin B-6 status and explored the potential association of functional vitamin B-6 status with long-term mortality in RTRs.Design: In a longitudinal cohort of 678 stable RTRs with a median follow-up of 5.3 y (IQR: 4.8-6.1 y) and 297 healthy controls, PLP, plasma 3-hydroxykynurenine (3-HK), and xanthurenic acid (XA) were analyzed via validated assays. PLP was used as direct biomarker for vitamin B-6 status, and the 3-HK:XA ratio was used as functional biomarker of vitamin B-6 status with a higher ratio reflecting worse functional vitamin B-6 ...
http://tpp.uah.edu/aggregator/sources/15?page=3
Wu, F<...Wu, F<...
Wu, F; Christen, P; Gehring, H (2011). A novel approach to inhibit intracellular vitamin B6-dependent enzymes: proof of principle with human and plasmodium ornithine decarboxylase and human histidine decarboxylase. FASEB Journal, 25(7):2109-2122.. Wu, F; Saleem, M A; Kampik, N B; Satchwell, T J; Williamson, R C; Blattner, S M; Ni, L; Toth, T; White, G; Young, M T; Parker, M D; Alper, S L; Wagner, C A; Toye, A M (2010). Anion exchanger 1 interacts with nephrin in podocytes. Journal of the American Society of Nephrology (JASN), 21(9):1456-1467.. Müller, I B; Wu, F; Bergmann, B; Knöckel, J; Walter, R D; Gehring, H; Wrenger, C (2009). Poisoning pyridoxal 5-phosphate-dependent enzymes: a new strategy to target the malaria parasite Plasmodium falciparum. PLoS ONE, 4(2):e4406.. Wu, F; Gehring, H (2009). Structural requirements for novel coenzyme-substrate derivatives to inhibit intracellular ornithine decarboxylase and cell proliferation. FASEB Journal, 23(2):565-574.. Wu, F; Yu, J; Gehring, H ...
http://www.zora.uzh.ch/view/authors_for_linking_in_citation/Wu=3AF=3A=3A.html
Plus itPlus it
In this prospective, nested case-control study, we found that men with higher plasma PLP levels (above the median level) at baseline had a significantly lower risk of developing future colorectal cancer. The association was independent of conventional risk factors and plasma levels of biomarkers involved in one-carbon metabolism or inflammatory processes. The inverse association remained statistically significant after exclusion of cancer cases diagnosed during the first 4 years of follow-up, suggesting that the protective effect of PLP was unlikely to be influenced by preclinical disease or by change of diet.. We found a significant 51% lower risk of colorectal cancer among men in the highest quartiles than in the lowest quartiles of plasma PLP levels. Our findings in men are consistent with the previous findings in women (5), which observed a significant 52% reduction in colorectal cancer risk comparing the highest with the lowest quartiles (Ptrend = 0.07). A recent nested case-control study ...
http://cebp.aacrjournals.org/content/18/4/1197
Kemija vitamina B6 i sinteza novih analoga vitamina B6 | Repozitorij Odjela za kemiju, OsijekKemija vitamina B6 i sinteza novih analoga vitamina B6 | Repozitorij Odjela za kemiju, Osijek
Vitamin B6 exists in three basic chemical forms: pyridoxine (an alcohol), pyridoxal (an aldehyde) and pyridoxamine (a primary amine). The three major forms can be phosphorylated at the 5-hydroxymethyl group. The first total synthesis of vitamin B6 was obtained by the condensation of acetylacetone and cyanacetamide. All living beings need vitamin B6 for their existence. However, only microorganisms and plants are able to synthesize it de novo. The role of vitamin B6 is related to a number of metabolic processes , and also plays a role like a cofactor in certain enzyme-catalyzed reactions. Vitamin B6 is essential for more than 100 enzymes involved in protein metabolism. The most studied coenzymic activity is one of the pytidoxal-5-phosfate (PLP), PLP-dependent enzymes are involved in important steps of amino acid metabolism, processes of decarboxylation and racemization, hemoglobin formation and chlorophyll biosynthesis. Vitamin B6 could have a role in preventing oxidative stress of the cells. A ...
https://repozitorij.kemija.unios.hr/islandora/object/kemos%3A111
FoodScience of Vermont Pyridoxal 5-Phosphate - 60 VCapsules Customer Reviews - eVitamins AustraliaFoodScience of Vermont Pyridoxal 5-Phosphate - 60 VCapsules Customer Reviews - eVitamins Australia
Read the latest Pyridoxal 5-Phosphate by FoodScience of Vermont reviews and find the latest results, side effects and user experiences from eVitamins. Have you taken Pyridoxal 5-Phosphate by FoodScience of Vermont? Submit your own Pyridoxal 5-Phosphate review and let the world know what you think. Australia
https://www.evitamins.com/au/reviews/pyridoxal-5-phosphate-food-science-12522
Pyridoxal hydrochloride, 99%, ACROS Organics™ 100g; Glass bottle Pyridoxal hydrochloride, 99%, ACROS Organics™ | Fisher...Pyridoxal hydrochloride, 99%, ACROS Organics™ 100g; Glass bottle Pyridoxal hydrochloride, 99%, ACROS Organics™ | Fisher...
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Criteria of supply of vitamins B1, B2, and B6 in children with insulin-dependent diabetes mellitusCriteria of supply of vitamins B1, B2, and B6 in children with insulin-dependent diabetes mellitus
Abstract: By mathematically analysing the curves of urinary excretion of vitamins, their plasma and erythrocytic concentrations or of TDP-effect, by constructing and mathematically interpreting the variation curves of distribution of a given plasma concentration of riboflavin and pyridoxal phosphate for 10-14-old-year children suffering from insulin-dependent diabetes mellitus after supplementation of vitamin, as a criterion of normal requirement for vitamin B2, the authors are prone to recommend the concentration of riboflavin over 10 micrograms/ml in plasma and over 96 micrograms/ml in erythrocytes, the hourly excretion of more than 27 micrograms. It has been ascertained that the criteria for the optimal bodys requirements for vitamins in diabetes mellitus children do not differ from those in healthy age-matched children. Thus, the value of TDP-effect is less than 1.25, the concentration of pyridoxal phosphate is over 8.4 micrograms/ml plasma, the excretion values of thiamine and 4-pyridoxic ...
http://pbmc.ibmc.msk.ru/index.php/en/article/PBMC-1995-41-6-58-en
Pyridoxal phosphate as coenzyme of diamine oxidase | Biochemical JournalPyridoxal phosphate as coenzyme of diamine oxidase | Biochemical Journal
Thank you for your interest in spreading the word about Biochemical Journal.. NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.. ...
http://www.biochemj.org/content/64/3/546
pdxS - Pyridoxal 5-phosphate synthase subunit PdxS - Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) - pdxS gene &...pdxS - Pyridoxal 5-phosphate synthase subunit PdxS - Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) - pdxS gene &...
Catalyzes the formation of pyridoxal 5-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively.
https://uniprot.org/uniprot/P9WII9
pdxT - Pyridoxal 5-phosphate synthase subunit PdxT - Thermotoga sp. (strain RQ2) - pdxT gene & proteinpdxT - Pyridoxal 5-phosphate synthase subunit PdxT - Thermotoga sp. (strain RQ2) - pdxT gene & protein
Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS.
http://www.uniprot.org/uniprot/B1L921
Pyridoxal - DrugBankPyridoxal - DrugBank
The 4-carboxyaldehyde form of vitamin B 6 which is converted to pyridoxal phosphate which is a coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, aminolevulinic acid. [PubChem]
https://www.drugbank.ca/drugs/DB00147
TIGR04434TIGR04434
Members of this family are radical SAM domain (PF04055) enzymes with an N-terminal B12-binding domain (PF02310), as is fairly common for radical SAM enzymes with lipid substrates. However, both domains as found in this family seem to be long-branch and mostly score below the cutoffs for their respective HMMs. The function is unknown, but all cases a PLP-dependent enzyme (a cysteine desulfurase homolog) is found nearby ...
http://www.jcvi.org/cgi-bin/tigrfams/HmmReportPage.cgi?acc=TIGR04434
Plasma pyridoxal 5-phosphate [active co-enzyme form of vitamin B-6] in the US population: The National Health and Nutrition...Plasma pyridoxal 5-phosphate [active co-enzyme form of vitamin B-6] in the US population: The National Health and Nutrition...
Particularly for substantial proportions of smokers, the elderly, non-Hispanic blacks, and current and former oral contraceptive users, the U.S. RDA f
http://www.prohealth.com/library/showarticle.cfm?libid=13727
1gc2.1 | SWISS-MODEL Template Library
SWISS-MODEL Template Library (SMTL) entry for 1gc2.1. CRYSTAL STRUCTURE OF THE PYRIDOXAL-5-PHOSPHATE DEPENDENT L-METHIONINE GAMMA-LYASE FROM PSEUDOMONAS PUTIDA
https://swissmodel.expasy.org/templates/1gc2
Pyridoxal 5 Phosphate Manufacturer, Supplier, Exporter From Ahmedabad, IndiaPyridoxal 5 Phosphate Manufacturer, Supplier, Exporter From Ahmedabad, India
We, MARUTI CHEMICALS is one of the prominent leading Manufacturer, Supplier and Exporter of Pyridoxal 5 Phosphate based In Yogeshwar Complex, Thaltej, Ahmedabad, Gujarat, India
https://www.marutichemicals.net/pyridoxal-5-phosphate-2998681.html
SDS serine dehydratase [Homo sapiens (human)] - Gene - NCBISDS serine dehydratase [Homo sapiens (human)] - Gene - NCBI
This gene encodes one of three enzymes that are involved in metabolizing serine and glycine. L-serine dehydratase converts L-serine to pyruvate and ammonia and requires pyridoxal phosphate as a cofactor. The encoded protein can also metabolize threonine to NH4+ and 2-ketobutyrate. The encoded protein is found predominantly in the liver. [provided by RefSeq, Jul 2008 ...
https://0-www-ncbi-nlm-nih-gov.brum.beds.ac.uk/gene?LinkName=geoprofiles_gene&from_uid=121043643
Proteins matched: Pyridoxal 5-phosphate synthase subunit PdxT/SNO (IPR002161) | InterPro | EMBL-EBIProteins matched: Pyridoxal 5-phosphate synthase subunit PdxT/SNO (IPR002161) | InterPro | EMBL-EBI
InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites. We combine protein signatures from a number of member databases into a single searchable resource, capitalising on their individual strengths to produce a powerful integrated database and diagnostic tool.
http://www.ebi.ac.uk/interpro/entry/IPR002161/proteins-matched
ChemIDplus - 1053-73-2 - WHTCPDAXWFLDIH-KQYNXXCUSA-N - Adenosine 3-phosphate-5-phosphate - Similar structures search,...ChemIDplus - 1053-73-2 - WHTCPDAXWFLDIH-KQYNXXCUSA-N - Adenosine 3-phosphate-5-phosphate - Similar structures search,...
1053-73-2 - WHTCPDAXWFLDIH-KQYNXXCUSA-N - Adenosine 3-phosphate-5-phosphate - Similar structures search, synonyms, formulas, resource links, and other chemical information.
https://chem.nlm.nih.gov/chemidplus/rn/1053-73-2
Pyridoxal-5-Phosphate - 90 TabletsPyridoxal-5-Phosphate - 90 Tablets
Pyridoxal-5-Phosphate from Nutri West is a vitamin B6 supplement that may promote the healthy function of numerous parts of the body-SHIPPING IS FREE!
https://www.pureformulas.com/pyridoxal5phosphate-90-tablets-by-nutri-west.html?N=4294854891
Pyridoxal 5 Phosphate Caps 60 vcaps by Life ExtensionPyridoxal 5 Phosphate Caps 60 vcaps by Life Extension
Product Description Dietary Supplement Advanced Formula of Vitamin B6Product BenefitsIngredientsSuggestionsTake one (1) capsule daily with food, or as recommended by a healthcare practitioner.Extra InfoSpecial NoteWarningsKeep out of reach of children. Do not exceed recommended dose. Do not purchase if outer seal is br
https://www.herbsdaily.com/collections/other-vitamins-products/products/pyridoxal-5-phosphate-caps-35952
Sequence Similarity Search - BLAST
eck:EC55989_3962 K01580 glutamate decarboxylase [EC:4.1.1.15] , (GenBank) gadA; glutamate decarboxylase A, PLP-dependent (A) MDQKLLTDFRSELLDSRFGAKAISTIAESKRFPLHEMRDDVAFQIINDELYLDGNARQNL ATFCQTWDDENVHKLMDLSINKNWIDKEEYPQSAAIDLRCVNMVADLWHAPAPKNGQAVG TNTIGSSEACMLGGMAMKWRWRKRMEAAGKPTDKPNLVCGPVQICWHKFARYWDVELREI PMRPGQLFMDPKRMIEACDENTIGVVPTFGVTYTGNYEFPQPLHDALDKFQADTGIDIDM HIDAASGGFLAPFVAPDIVWDFRLPRVKSISASGHKFGLAPLGCGWVIWRDEEALPQELV FNVDYLGGQIGTFAINFSRPAGQVIAQYYEFLRLGREGYTKVQNASYQVAAYLADEIAKL GPYEFICTGRPDEGIPAVCFKLKDGEDPGYTLYDLSERLRLRGWQVPAFTLGGEATDIVV MRIMCRRGFEMDFAELLLEDYKASLKYLSDHPKLQGIAQQNSFKHT ...
http://www.genome.jp/tools-bin/search_sequence?prog=blast&seqid=eck:EC55989_3962+aa
Source Naturals - 4AllVitamins
In order for vitamins to be utilized by the body, they must first be converted into their active coenzyme forms. This Coenzymated B-6 goes directly into your bloodstream in its active form and ready to go to work immediately. Pyridoxal-5-Phosphate (PLP or P-5-P) is the main metabolically active coenzyme form of vitamin B-6. It is primarily in the liver that P-5-P is synthesized from pyrid... [Read More ...
http://www.4allvitamins.com/index.php?manufacturer_id=411&page=4&product_listing_preference=list
Serine Hydroxymethyltransferase from Mung Bean (Vigna radiata) Is Not a Pyridoxal-5-Phosphate- Dependent Enzyme ePrints@IIScSerine Hydroxymethyltransferase from Mung Bean (Vigna radiata) Is Not a Pyridoxal-5-Phosphate- Dependent Enzyme [email protected]
Serine hydroxymethyltransferase from mammalian and bacterial sources is a pyridoxal-5-phosphate-containing enzyme, but the requirement of pyridoxal-5-phosphate for the activity of the enzyme from plant sources is not clear. The specific activity of serine hydroxymethyltransferase isolated from mung bean (Vigna radiata) seedlings in the presence and absence of pyridoxal-5-phosphate was comparable at every step of the purification procedure. The mung bean enzyme did not show the characteristic visible absorbance spectrum of pyridoxal-5-phosphate protein. Unlike the enzymes from sheep, monkey, and human liver, which were converted to the apoenzyme upon treatment with L-cysteine and dialysis, the mung bean enzyme similarly treated was fully active. Additional evidence in support of the suggestion that pyridoxal-5-phosphate may not be required for the mung bean enzyme was the observation that pencillamine, a well-known inhibitor of pyridoxal-5-phosphate enzymes, did not perturb the enzyme ...
http://eprints.iisc.ac.in/34126/
Pyridoxal phosphate induced association reactions of adrenodoxin and adrenodoxin-reductase - MDC RepositoryPyridoxal phosphate induced association reactions of adrenodoxin and adrenodoxin-reductase - MDC Repository
Adrenodoxin, Ferredoxin-NADP Reductase, Hydrogen Bonding, Kinetics, Molecular Weight, Protein Conformation, Pyridoxal Phosphate, Ultracentrifugation, ...
http://edoc.mdc-berlin.de/2402/
Pyridoxine Hydrochloride Nicotinamide Cyanocobalamin & Lysine Hydrochloride Syrup 200 ml Exporter,Pyridoxine Hydrochloride...
MATMON PHARMACEUTICALS - We are one of the well known exporter, supplier, and trader of Pyridoxine Hydrochloride Nicotinamide Cyanocobalamin & Lysine Hydrochloride Syrup 200 ml. We give our best to satisfy clients, as for us the reputation of our company is very important.
https://m.matmonpharma.com/pyridoxine-hydrochloride-nicotinamide-cyanocobalamin-lysine-hydrochloride-syrup-200-ml-5103433.html
EC 2.6.1.52EC 2.6.1.52
2) 4-phosphonooxy-L-threonine + 2-oxoglutarate = (3R)-3-hydroxy-2-oxo-4-phosphonooxybutanoate + L-glutamate. For diagram, click here or here or here for mechanism click here.. Other name(s): PSAT; phosphoserine aminotransferase; 3-phosphoserine aminotransferase; hydroxypyruvic phosphate-glutamic transaminase; L-phosphoserine aminotransferase; phosphohydroxypyruvate transaminase; phosphohydroxypyruvic-glutamic transaminase; phosphoserine aminotransferase; 3-O-phospho-L-serine:2-oxoglutarate aminotransferase; SerC; PdxC; 3PHP transaminase. Systematic name: O-phospho-L-serine:2-oxoglutarate aminotransferase. Comments: A pyridoxal-phosphate protein. This enzyme catalyses the second step in the phosphorylated pathway of serine biosynthesis in Escherichia coli [2,3]. It also catalyses the third step in the biosynthesis of the coenzyme pyridoxal 5-phosphate in Escherichia coli (using Reaction 2 above) [3]. In Escherichia coli, pyridoxal 5-phosphate is synthesized de novo by a pathway that involves EC ...
http://www.sbcs.qmul.ac.uk/iubmb/enzyme/EC2/6/1/52.html
Uridine-5-diphospho-α-D-galactose disodium salt (CAS 137868-52-1) Market Research Report 2018Uridine-5-diphospho-α-D-galactose disodium salt (CAS 137868-52-1) Market Research Report 2018
Uridine-5-diphospho-α-D-galactose disodium salt (CAS 137868-52-1) Market Research Report 2018 aims at providing comprehensive data on uridine-5-diphospho-α-d-galactose
https://marketpublishers.com/report/industry/chemicals_petrochemicals/udp-alpha-d-galactose_disodium_salt_137868-52-1_market_research_report.html
PHARMA CAP: VIZYLAC CAPSULE
Vitamin B6 is the collective term for a group of three related compounds, pyridoxine (PN), pyridoxal (PL) and pyridoxamine (PM), and their phosphorylated derivatives, pyridoxine 5-phosphate (PNP), pyridoxal 5-phosphate (PLP) and pyridoxamine 5-phosphate (PMP). Although all six of these compounds should technically be referred to as vitamin B6, the term vitamin B6 is commonly used interchangeably with just one of them, pyridoxine. Vitamin B6, principally in its biologically active coenzyme form pyridoxal 5-phosphate, is involved in a wide range of biochemical reactions, including the metabolism of amino acids and glycogen, the synthesis of nucleic acids, hemogloblin, sphingomyelin and other sphingolipids, and the synthesis of the neurotransmitters serotonin, dopamine, norepinephrine and gamma-aminobutyric acid (GABA ...
http://www.keralapharmacist.com/2014/08/vizylac-capsule.html
Pyridoxine Hydrochloride Dangers | Livestrong.comPyridoxine Hydrochloride Dangers | Livestrong.com
Pyridoxine hydrochloride, or vitamin B6, is a member of the B complex family. This vitamin is found in high quantities in foods such as bananas, sardines, chicken spinach and avocados, according to the website dietbites.com. Pyridoxine hydrochloride is necessary for proper nerve function and for metabolizing nutrients.
https://www.livestrong.com/article/181931-pyridoxine-hydrochloride-dangers/
Pyridoxine Hydrochloride Nicotinamide Cyanocobalamin L Lysine Multivitamin Multimineral SyrupsPyridoxine Hydrochloride Nicotinamide Cyanocobalamin L Lysine Multivitamin Multimineral Syrups
Pyridoxine Hydrochloride 0.75mg + Nicotinamide 15mg + Cyanocobalamin 2mcg + L Lysine 375mg + Multivitamin + Multimineral Syrups Manufacturer, Franchise Suppliers & exporters in India.
https://www.pharmakhabar.com/surat/pyridoxine-hydrochloride-nicotinamide-cyanocobalamin-l-lysine-multivitamin-multimineral-syrups
JCI - WelcomeJCI - Welcome
Background. The majority of patients receiving the platinum-based chemotherapy drug oxaliplatin develop peripheral neurotoxicity. Because this neurotoxicity involves ROS production, we investigated the efficacy of mangafodipir, a molecule that has antioxidant properties and is approved for use as an MRI contrast enhancer.. Methods. The effects of mangafodipir were examined in mice following treatment with oxaliplatin. Neurotoxicity, axon myelination, and advanced oxidized protein products (AOPPs) were monitored. In addition, we enrolled 23 cancer patients with grade ≥2 oxaliplatin-induced neuropathy in a phase II study, with 22 patients receiving i.v. mangafodipir following oxaliplatin. Neuropathic effects were monitored for up to 8 cycles of oxaliplatin and mangafodipir.. Results. Mangafodipir prevented motor and sensory dysfunction and demyelinating lesion formation. In mice, serum AOPPs decreased after 4 weeks of mangafodipir treatment. In 77% of patients treated with oxaliplatin and ...
https://j8k9.com.www.mobile.jci.org/tags/17?content=articles&page=3
Pyridoxine 5-phosphate synthase superfamily
The SCOP classification for the Pyridoxine 5-phosphate synthase superfamily including the families contained in it. Additional information provided includes InterPro annotation (if available), Functional annotation, and SUPERFAMILY links to genome assignments, alignments, domain combinations, taxonomic visualisation and hidden Markov model information.
http://supfam.cs.bris.ac.uk/SUPERFAMILY/cgi-bin/scop.cgi?sunid=63892
PYRIDOXINE HYDROCHLORIDE (VITAMIN B6 HYDROCHLORIDE)
Pyridoxine is a vitamin of the B group. It is used as a vitamin supplement and to prevent the nerve damage. It acts as coenzyme and Cofactor in carbohydrate (stored as energy in the liver and muscles), amino acid and fat metabolism. Pyridoxine is also necessary for the for the conversion of tryptophan to vitamin B3, niacin. It acts for the production of blood cells and antibodies.. Molecular compounds of Pyridoxine. ...
http://www.chemicalland21.com/lifescience/phar/PYRIDOXINE%20HYDROCHLORIDE.htm
Pyridoxal 5′ phosphate Archives - Nootropic SourcePyridoxal 5′ phosphate Archives - Nootropic Source
What is P-5-P Powder (Vitamin b6) Pyridoxal 5′ phosphate (PLP), otherwise known as P5P, can be found in supplement form as an alternative to taking B6 (pyridoxine). In a healthy…. ...
https://nootropicsource.com.au/product-tag/pyridoxal-5%E2%80%B2-phosphate/
How Pyridoxine hydrochloride (Vitamin B6) works for bodybuildersHow Pyridoxine hydrochloride (Vitamin B6) works for bodybuilders
Pyridoxal Hydrochloride(65-22-5),also called vitamin B6 is a water-soluble vitamin commonly found in foods. It is usually taken by injection, orally or in food supplements.
https://www.aasraw.com/pyridoxine-hydrochloride-works-for/
PDXDC1 (pyridoxal dependent decarboxylase domain containing 1)PDXDC1 (pyridoxal dependent decarboxylase domain containing 1)
PDXDC1 (pyridoxal dependent decarboxylase domain containing 1), Authors: Dessen P. Published in: Atlas Genet Cytogenet Oncol Haematol.
http://atlasgeneticsoncology.org/Genes/GC_PDXDC1.html
August 2017 - Small-Molecule Inhibitors of Protein Interactions
Glutamate-1-semialdehyde-2,1-aminomutase (GSAM) catalyzes the isomerization of glutamate-1-semialdehyde (GSA) to 5-aminolevulinate (ALA) and is distributed in archaea, most bacteria and plants. of DAVA (Fig. 1 ?, step 2 2). The intermediate DAVA is definitely then produced accompanied by the formation of an internal aldimine between PLP and the active-site lysine part chain (Fig. 1 ?, step… Read more Glutamate-1-semialdehyde-2,1-aminomutase (GSAM) catalyzes the isomerization of glutamate-1-semialdehyde (GSA) to 5-aminolevulinate (ALA). ...
http://www.conferencecallsworld.com/2017/08/
HPLC Methods for analysis of Pyridoxal - HELIX ChromatographyHPLC Methods for analysis of Pyridoxal - HELIX Chromatography
HELIX Chromatography is pioneering HPLC with new mixed-mode columns. Buy HPLC Columns from the manufacturer in Chicago. HPLC Methods for analysis of Pyridoxal
https://helixchrom.com/compounds/pyridoxal/
Pyridoxine hydrochloride (ቫይታሚን B6) ለሰውነት ግንባታዎች እንዴት እንደሚሠራPyridoxine hydrochloride (ቫይታሚን B6) ለሰውነት ግንባታዎች እንዴት እንደሚሠራ
Pyridoxal Hydrochloride (65-22-5), እንዲሁም ቫይታሚን B6 ተብሎም የሚጠራው በምግብ ውስጥ በተለምዶ በውሃ ውስጥ የሚሟሟ ቫይታሚን ነው ፡፡ ብዙውን ጊዜ በመርፌ ፣ በአፍ ወይም በምግብ ማሟያዎች ይወሰዳል።
https://am.aasraw.com/pyridoxine-hydrochloride-works-for/
Allergy Research Group Pyridoxine P5P 275 mg, 60 capsulesAllergy Research Group Pyridoxine P5P 275 mg, 60 capsules
Allergy Research Group Pyridoxine P5P features pyridoxine hydrochloride and pyridoxal-5-phosphate (P5P), two forms of the vitamin B6.
https://drdonistore.com/Pyridoxine-P5P-275-mg-60-capsules_p_373.html
Pyridoxine - DrugBankPyridoxine - DrugBank
Pyridoxine is the 4-methanol form of vitamin B6, an important water-soluble vitamin that is naturally present in many foods. As its classification as a vitamin implies, Vitamin B6 (and pyridoxine) are essential nutrients required for normal functioning of many biological systems within the body. While many plants and microorganisms are able to synthesize pyridoxine through endogenous biological processes, animals must obtain it through their diet. More specifically, pyridoxine is converted to pyridoxal 5-phosphate in the body, which is an important coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, and aminolevulinic acid. Its important to note that Vitamin B6 is the collective term for a group of three related compounds, pyridoxine, pyridoxal, and pyridoxamine, and their phosphorylated derivatives, pyridoxine 5-phosphate, pyridoxal 5-phosphate and pyridoxamine 5-phosphate. Although all six of these compounds should technically be referred to as
https://www.drugbank.ca/drugs/DB00165
Paula L Roeschs Research on D-serine dehydratase | CureHunterPaula L Roeschs Research on D-serine dehydratase | CureHunter
Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day ...
http://www.curehunter.com/public/authorSummary-Roesch,%20Paula%20L.do?keywordId=C101950
Douglas Labs Pyridoxal-5-Phosphate 50mg 100 CapsDouglas Labs Pyridoxal-5-Phosphate 50mg 100 Caps
Douglas Labs, Pyridoxal-5-Phosphate 50mg, P5P, Vitamin B6, neurotransmitters, emotional response, pain perception, and anxiety, cardiovascular health, vitamin b
http://www.supervits.com/douglas-labs-pyridoxal-5-phosphate-50mg-100-caps-p9097.aspx
iHerb.com - Customer Reviews -Thorne Research, Pyridoxal 5-Phosphate, 180 Vegetarian CapsulesiHerb.com - Customer Reviews -Thorne Research, Pyridoxal 5-Phosphate, 180 Vegetarian Capsules
I love Thorne products and P-5-P is an activated form of B6 and highly absorbable. I used to take a ionic P-5-P prescribed by my doctor as I have a condition which depletes my body in zinc and B6. This ionic vitamin had to be refrigerated and since I spend a good portion of my time traveling I was keen to find a stable source of good quality. This is it! I love Thorne products and this products really works for me. B6 is necessary for the synthesis of serotonin and dopamine (feel good hormones) as well as triptophan. Also highly important for digestion and so on. I highly recommend this product! ...
https://www.iherb.com/r/thorne-research-pyridoxal-5-phosphate-180-veggie-caps/18472/?p=1
Vitamin B6 | Memorial HospitalVitamin B6 | Memorial Hospital
Learn more about Vitamin B6 at Memorial Hospital Supplement Forms/Alternate Names Pyridoxine Pyridoxine Hydrochloride Pyridoxal-5-Phosphate Uses Principal...
https://memorialhospitaljax.com/hl/?/21852/Vitamin-B6&com.dotmarketing.htmlpage.language=1
Vitamin B6 | Doctors HospitalVitamin B6 | Doctors Hospital
Learn more about Vitamin B6 at Doctors Hospital of Augusta Supplement Forms/Alternate Names Pyridoxine Pyridoxine Hydrochloride Pyridoxal-5-Phosphate Uses Principal...
https://doctors-hospital.net/hl/?/21852/Vitamin-B-6&com.dotmarketing.htmlpage.language=1
Vitamin B6 | Doctors HospitalVitamin B6 | Doctors Hospital
Learn more about Vitamin B6 at Doctors Hospital of Augusta Supplement Forms/Alternate Names Pyridoxine Pyridoxine Hydrochloride Pyridoxal-5-Phosphate Uses Principal...
https://doctors-hospital.net/hl/?/21852/Pyridoxine&com.dotmarketing.htmlpage.language=1
Welcome to Chem Zipper.com......: Pyridine is almost 1 million times less basic than piperidine? Why?
We know that if nitrogen is part of an aromatic ring, however, its basicity decreases markedly. So in pyridine nitrogen is part of an aromatic ring hence its basicity is much more less than piperidine. The difference between the two lies in the fact that the nitrogen lone pair occupies an sp3- hybridized orbital in piperidine versus an sp2-hybridized one in pyridine. As we have noted on several occasions, electrons in orbitals with more s character are more strongly held than those with less s character. For this reason, nitrogen holds on to its unshared pair more strongly in pyridine than in piperidine and is less basic ...
https://www.chemzipper.com/2019/12/pyridine-is-almost-1-million-times-less.html
Source Naturals Coenzymated Sublinguals - Source Naturals - Coenzymated B-6 Sublingual 25mg - 60 tabs
Coenzymated B-6 Pyridoxal-5-Phosphate Tablets In order for vitamins to be utilized by the body, they must first be converted into their active coenzyme forms. This more potent Coenzymated B-6 is in its active form and ready to go to work immediately. Pyridoxal-5-Phosphate (PLP or P-5-P) is the main metabolically active coenzyme form of vitamin B-6. It is primarily in the liver that P-5-P is synthesized from pyridoxine, with the help of enzymes that require B-2, zinc and magnesium for their activity. P-5-P activates over 100 enzymes, many of which are involved in the conversion of amino acids into the neurotransmitters dopamine, norepinephrine and serotonin. P-5-P is also required for the synthesis of the hemoglobin molecule and plays an important role in regulating homocysteine levels. The Benefits of Coenzymated Sublingual Vitamins Coenzymated sublingual B-6 goes directly into your bloodstream in its active form. This avoids the loss that may occur not only during digestion, but during
https://www.totaldiscountvitamins.com/product/13170/source_naturals_coenzymated__sublinguals
Pharmaceutical Composition Free From Dexpanthenol, Calcium Ions, and Phosphate and Use of Calcium Chelating Agent and...Pharmaceutical Composition Free From Dexpanthenol, Calcium Ions, and Phosphate and Use of Calcium Chelating Agent and...
TABLE-US-00006 TABLE 1 Result of calcification and healing Severity of the Calcification Run Cornea Type of calci- occurred Healing no. no. exposure fication (≧1) [%] 1 HH1 medium 1 yes 49.7 1 HH2 phosphate- 0 no 89.8 free 1 HH3 phosphate- 4 yes 22 containing 2 HH7 medium 4 yes 97.8 2 HH8 phosphate- 0 no 100 free 2 HH9 phosphate- 3 yes 92 containing 3 HH13 medium 3 yes n.d. 3 HH16 phosphate- 4 yes n.d. free 3 HH17 phosphate- 0 no 94.8 containing Explanation of the table: 1 n.d.: not determined. 2 The details of the healing in % indicates the size of the healed area relative to the original area of the corneal injury. 3 The strength of the calcification was indicated by means of the value numbers 1 to 5, the assessment taking place with the naked eye and the value numbers standing for the following assessments: 0: no sclerotic phenomena 1: first scleroses are discernible with the naked eye 2: slight sclerosis 3: medium severe sclerosis 4: severe sclerosis 5: complete sclerosis ...
http://www.patentsencyclopedia.com/app/20090111770
SWISS-MODEL Repository | A0RTP4
SWISS-MODEL Repository entry for A0RTP4 (PDXT_CENSY), Pyridoxal 5-phosphate synthase subunit PdxT. Cenarchaeum symbiosum (strain A)
https://swissmodel.expasy.org/repository/uniprot/A0RTP4
Ausgewählte Publikationen des Jahres 2014 • Chemie • Fachbereich Biologie, Chemie, PharmazieAusgewählte Publikationen des Jahres 2014 • Chemie • Fachbereich Biologie, Chemie, Pharmazie
NMR Studies of Protonation and Hydrogen Bond States of Internal Aldimines of Pyridoxal 5-Phosphate Acid-Base in Alanine Racemase, Aspartate Aminotransferase and Poly-L-lysine. Monique Chan-Huot, Alexandra Dos, Reinhard Zander, Shasad Sharif, Peter M. Tolstoy, Shara Compton, Emily Fogle, Michael D. Toney, Ilya Shenderovich, Gleb S. Denisov, and Hans-Heinrich Limbach, J. Am. Chem. Soc. 2013, 135(48), 18160-18175. ...
https://www.bcp.fu-berlin.de/chemie/chemie/_PaperHighlightsArchive/2014.html
Anti-inosine 5-phosphate dehydrogenase 2 Antibody Products from Novus Biologicals | BiocompareAnti-inosine 5-phosphate dehydrogenase 2 Antibody Products from Novus Biologicals | Biocompare
Compare Anti-inosine 5-phosphate dehydrogenase 2 Antibody Products from Novus Biologicals from leading suppliers on Biocompare. View specifications, prices, citations, reviews, and more.
https://www.biocompare.com/pfu/110447/soids/1023105/Antibodies/inosine_5-phosphate_dehydrogenase_2?vids=100434
O-Phosphoséryl-ARNt:sélénocystéinyl-ARNt synthase - WikipédiaO-Phosphoséryl-ARNt:sélénocystéinyl-ARNt synthase - Wikipédia
Cette enzyme utilise le phosphate de pyridoxal comme cofacteur[2]. Chez les archées et les eucaryotes, la formation du sélénocystéinyl-ARNtSec se déroule en effet en deux étapes[3],[4],[5] : la O-phosphoséryl-ARNtSec kinase catalyse tout dabord la phosphorylation dun L-séryl-ARNtSec en O-phosphoL-séryl-ARNtSec, lequel est ensuite converti en L-sélénocystéinyl-ARNtSec par la O-phosphoséryl-ARNt:sélénocystéinyl-ARNt synthase. ...
https://fr.m.wikipedia.org/wiki/O-Phosphos%C3%A9ryl-ARNt:s%C3%A9l%C3%A9nocyst%C3%A9inyl-ARNt_synthase
SAUSA300 0504 - AureoWikiSAUSA300 0504 - AureoWiki
Staphylococcus aureus; strain: USA300_FPR3757; locus tag: SAUSA300_0504 (SAUSA300_RS02700); symbol: pdxS; product: pyridoxal biosynthesis lyase PdxS
https://aureowiki.med.uni-greifswald.de/SAUSA300_0504
INT267091 - wiki-pain
Enhanced migration into the cortex induced by P2X receptor blockade during OGD was also suggested by cell spreading observed by DCX immunofluorescence 24 hours after PPADS/OGD treatment (Figure 3A ...
http://gnteam.cs.manchester.ac.uk/demos/wiki-pain/vhosts/wikipaints/mediawiki-1.19.1/index.php/INT267091
组氨酸脱羧酶 - 维基百科，自由的百科全书组氨酸脱羧酶 - 维基百科，自由的百科全书
在人体中，组氨酸脱羧酶由HDC基因编码。[4][5]. 生物胺组织胺在许多生理过程中有重要的调节作用，包括神经传递、胃酸分泌、平滑肌舒张。从组氨酸到组织胺的生物合成由L-组氨酸脱羧酶催化。这个同源二聚体酶是一个依赖磷酸吡哆醛（PLP）的脱羧酶，并对其底物组氨酸有高度特异性。[4]. ...
https://zh.wikipedia.org/wiki/%E7%BB%84%E6%B0%A8%E9%85%B8%E8%84%B1%E7%BE%A7%E9%85%B6
Pyridoxal phosphatePyridoxal phosphate
... (PLP, pyridoxal 5'-phosphate, P5P), the active form of vitamin B6, is a coenzyme in a variety of enzymatic ... Pyridoxal phosphate is a cofactor of ornithine carboxylase. Transamination. Pyridoxal phosphate takes part in decomposition and ... Pyridoxal phosphate has numerous roles in human body. A few examples below: Metabolism and biosynthesis of serotonin. Pyridoxal ... The condensation product of 3-hydroxy-1-aminoacetone phosphate and deoxyxylulose 5-phosphate is pyridoxine 5'-phosphate. The ...
https://en.wikipedia.org/wiki/Pyridoxal_phosphate
Magnesium pyridoxal 5-phosphate glutamateMagnesium pyridoxal 5-phosphate glutamate
... (trade name Sedalipid) is a hypolipidemic agent. Schuitemaker GE, van der Pol GA, ... Aretz CP, Dinant GJ (2001). "A placebo-controlled, double-blind, randomised trial of magnesium-pyridoxal-5'-phosphate-glutamate ...
https://en.wikipedia.org/wiki/Magnesium_pyridoxal_5-phosphate_glutamate
Pyridoxal 5-phosphate synthase (glutamine hydrolyzing)Pyridoxal 5'-phosphate synthase (glutamine hydrolyzing)
... pyridoxal 5′-phosphate + 4 H2O + phosphate The enzyme can also use ribulose 5-phosphate and dihydroxyacetone phosphate. Burns ... is an enzyme with systematic name D-ribose 5-phosphate,D-glyceraldehyde 3-phosphate pyridoxal 5′-phosphate-lyase. This enzyme ... pyridoxal 5′-phosphate + L-glutamate + 3 H2O + phosphate (overall reaction) (1a) L-glutamine + H2O ⇌ {\displaystyle \ ... Pyridoxal+5'-phosphate+synthase+(glutamine+hydrolyzing) at the US National Library of Medicine Medical Subject Headings (MeSH) ...
https://en.wikipedia.org/wiki/Pyridoxal_5'-phosphate_synthase_(glutamine_hydrolyzing)
Diaminopimelate decarboxylaseDiaminopimelate decarboxylase
"Pyridoxal phosphate". Pubchem. Retrieved 2018-03-09. Gillner DM, Becker DP, Holz RC (February 2013). "Lysine biosynthesis in ... It employs the cofactor pyridoxal phosphate, also known as PLP, which participates in numerous enzymatic transamination, ... Portal: Biology (EC 4.1.1, Pyridoxal phosphate enzymes, Enzymes of known structure). ...
https://en.wikipedia.org/wiki/Diaminopimelate_decarboxylase
Branched-chain amino acid aminotransferaseBranched-chain amino acid aminotransferase
"Pyridoxal phosphate enzymology". Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics. Pyridoxal Phosphate Enzymology ... Like other transaminase enzymes (as well as many enzymes of other classes), BCATs require the cofactor pyridoxal-5'-phosphate( ... In addition, the phosphate oxygen atoms on the PLP molecule interact with the Arg99, Val269, Val270, and Thr310 residues. ...
https://en.wikipedia.org/wiki/Branched-chain_amino_acid_aminotransferase
Histidine decarboxylaseHistidine decarboxylase
"Pyridoxal phosphate-dependent decarboxylase". InterPro. Toney MD (January 2005). "Reaction specificity in pyridoxal phosphate ... The enzyme employs a pyridoxal 5'-phosphate (PLP) cofactor, in similarity to many amino acid decarboxylases. Eukaryotes, as ... Sandmeier E, Hale TI, Christen P (May 1994). "Multiple evolutionary origin of pyridoxal-5'-phosphate-dependent amino acid ... Fernandes HS, Ramos MJ, Cerqueira NM (July 2017). "The Catalytic Mechanism of the Pyridoxal-5'-phosphate-Dependent Enzyme, ...
https://en.wikipedia.org/wiki/Histidine_decarboxylase
Cystathionine beta-lyaseCystathionine beta-lyase
The enzyme belongs to the γ-family of PLP-dependent enzymes due to its use of a pyridoxal-5'-phosphate (PLP) cofactor to cleave ... Clausen T, Huber R, Laber B, Pohlenz HD, Messerschmidt A (September 1996). "Crystal structure of the pyridoxal-5'-phosphate ... Portal: Biology (CS1: long volume value, EC 4.4.1, Pyridoxal phosphate enzymes, Enzymes of known structure). ... John RA (April 1995). "Pyridoxal phosphate-dependent enzymes". Biochimica et Biophysica Acta (BBA) - Protein Structure and ...
https://en.wikipedia.org/wiki/Cystathionine_beta-lyase
Arginine decarboxylaseArginine decarboxylase
The process consumes a proton in the decarboxylation and employs a pyridoxal-5'-phosphate (PLP) cofactor, similar to other ... John RA (April 1995). "Pyridoxal phosphate-dependent enzymes". Biochimica et Biophysica Acta (BBA) - Protein Structure and ... EC 4.1.1, Pyridoxal phosphate enzymes, Enzymes of known structure). ... Toney MD (January 2005). "Reaction specificity in pyridoxal phosphate enzymes". Archives of Biochemistry and Biophysics. 433 (1 ...
https://en.wikipedia.org/wiki/Arginine_decarboxylase
Pyridoxine 5-phosphate synthasePyridoxine 5'-phosphate synthase
... phosphate, and pyridoxine-5'-phosphate (a vitamer of pyridoxal phosphate). In the first step of this condensation reaction, the ... phosphate + phosphate + 2 H2O The two substrates of this enzyme are 1-deoxy-D-xylulose 5-phosphate (DXP) and 3-hydroxy-1- ... pdxJ plays a role in the DXP-dependent pathway of pyridoxal phosphate. The DXP-dependent pathway is found predominantly in ... Mukherjee T, Hanes J, Tews I, Ealick SE, Begley TP (November 2011). "Pyridoxal phosphate: biosynthesis and catabolism". ...
https://en.wikipedia.org/wiki/Pyridoxine_5'-phosphate_synthase
Acetylornithine transaminaseAcetylornithine transaminase
Portal: Biology v t e (EC 2.6.1, Pyridoxal phosphate enzymes, Enzymes of known structure, All stub articles, EC 2.6 stubs). ... It employs one cofactor, pyridoxal phosphate. As of late 2007, 6 structures have been solved for this class of enzymes, with ...
https://en.wikipedia.org/wiki/Acetylornithine_transaminase
Beta-alanine-pyruvate transaminaseBeta-alanine-pyruvate transaminase
Portal: Biology v t e (EC 2.6.1, Pyridoxal phosphate enzymes, Enzymes of unknown structure, All stub articles, EC 2.6 stubs). ... It employs one cofactor, pyridoxal phosphate. HAYAISHI O, NISHIZUKA Y, TATIBANA M, TAKESHITA M, KUNO S (1961). "Enzymatic ...
https://en.wikipedia.org/wiki/Beta-alanine—pyruvate_transaminase
Asparagine-oxo-acid transaminaseAsparagine-oxo-acid transaminase
Portal: Biology v t e (EC 2.6.1, Pyridoxal phosphate enzymes, Enzymes of unknown structure, All stub articles, EC 2.6 stubs). ... It employs one cofactor, pyridoxal phosphate. MEISTER A, FRASER PE (1954). "Enzymatic formation of L-asparagine by ...
https://en.wikipedia.org/wiki/Asparagine—oxo-acid_transaminase
Adenosylmethionine-8-amino-7-oxononanoate transaminaseAdenosylmethionine-8-amino-7-oxononanoate transaminase
Portal: Biology v t e (EC 2.6.1, Pyridoxal phosphate enzymes, Enzymes of known structure, All stub articles, EC 2.6 stubs). ... It employs one cofactor, pyridoxal phosphate. As of late 2007, 11 structures have been solved for this class of enzymes, with ...
https://en.wikipedia.org/wiki/Adenosylmethionine—8-amino-7-oxononanoate_transaminase
L-seryl-tRNASec selenium transferaseL-seryl-tRNASec selenium transferase
Portal: Biology v t e (EC 2.9.1, Pyridoxal phosphate enzymes, Enzymes of unknown structure, All stub articles, Transferase ... It employs one cofactor, pyridoxal phosphate. Forchhammer K, Bock A (1991). "Selenocysteine synthase from Escherichia coli. ... phosphate Thus, the two substrates of this enzyme are L-seryl-tRNASec and selenophosphate, whereas its two products are L- ... selenocysteinyl-tRNASec and phosphate. This enzyme belongs to the family of transferases, specifically those transferring ...
https://en.wikipedia.org/wiki/L-seryl-tRNASec_selenium_transferase
Threonine aldolaseThreonine aldolase
It employs one cofactor, pyridoxal phosphate. As of late 2007, 5 structures have been solved for this class of enzymes, with ... Portal: Biology v t e (Protein pages needing a picture, Genes on human chromosome 17, EC 4.1.2, Pyridoxal phosphate enzymes, ...
https://en.wikipedia.org/wiki/Threonine_aldolase
5-aminovalerate transaminase5-aminovalerate transaminase
Portal: Biology v t e (EC 2.6.1, Pyridoxal phosphate enzymes, Enzymes of unknown structure, All stub articles, EC 2.6 stubs). ... It employs one cofactor, pyridoxal phosphate. Ichihara A, Ichihara EA, Suda M (1960). "Metabolism of L-lysine by bacterial ...
https://en.wikipedia.org/wiki/5-aminovalerate_transaminase
D-amino-acid transaminaseD-amino-acid transaminase
Portal: Biology v t e (EC 2.6.1, Pyridoxal phosphate enzymes, Enzymes of known structure, All stub articles, EC 2.6 stubs). ... It employs one cofactor, pyridoxal phosphate. As of late 2007, 8 structures have been solved for this class of enzymes, with ...
https://en.wikipedia.org/wiki/D-amino-acid_transaminase
Aminobenzoate decarboxylaseAminobenzoate decarboxylase
Portal: Biology v t e (EC 4.1.1, Pyridoxal phosphate enzymes, Enzymes of unknown structure, All stub articles, EC 4.1 stubs). ... pyridoxal phosphate. McCullough WG, Piligian JT, Daniel IJ (1957). "Enzymatic decarboxylation of three aminobenzoates". J. Am. ...
https://en.wikipedia.org/wiki/Aminobenzoate_decarboxylase
Succinyldiaminopimelate transaminaseSuccinyldiaminopimelate transaminase
Portal: Biology v t e (EC 2.6.1, Pyridoxal phosphate enzymes, Enzymes of unknown structure, All stub articles, EC 2.6 stubs). ... It employs one cofactor, pyridoxal phosphate. Peterkofsky B, Gilvarg C (May 1961). "N-Succinyl-L-diaminopimelic-glutamic ...
https://en.wikipedia.org/wiki/Succinyldiaminopimelate_transaminase
3-chloro-D-alanine dehydrochlorinase3-chloro-D-alanine dehydrochlorinase
Portal: Biology v t e (EC 4.5.1, Pyridoxal phosphate enzymes, Enzymes of unknown structure, All stub articles, Lyase stubs). ... pyridoxal phosphate. Nagasawa T, Ishii T, Yamada H (1988). "Physiological comparison of D-cysteine desulfhydrase of Escherichia ...
https://en.wikipedia.org/wiki/3-chloro-D-alanine_dehydrochlorinase
Serine C-palmitoyltransferaseSerine C-palmitoyltransferase
The PLP (pyridoxal 5′-phosphate)-dependent serine C-palmitoyltransferase carries out the first enzymatic step of de novo ... It employs one cofactor, pyridoxal phosphate. This enzyme belongs to the family of transferases, specifically those ... Eliot AC, Kirsch JF (2004). "Pyridoxal phosphate enzymes: mechanistic, structural, and evolutionary considerations". Annual ... Pyridoxal phosphate enzymes, Enzymes of known structure). ...
https://en.wikipedia.org/wiki/Serine_C-palmitoyltransferase
Phenylalanine decarboxylasePhenylalanine decarboxylase
Portal: Biology v t e (EC 4.1.1, Pyridoxal phosphate enzymes, Enzymes of unknown structure, All stub articles, EC 4.1 stubs). ... It employs one cofactor, pyridoxal phosphate. Lovenberg W, Weissbach H, Udenfriend S (1962). "Aromatic L-amino acid ...
https://en.wikipedia.org/wiki/Phenylalanine_decarboxylase
Arginine racemaseArginine racemase
Portal: Biology v t e (EC 5.1.1, Pyridoxal phosphate enzymes, Enzymes of unknown structure, All stub articles, Isomerase stubs) ... It employs one cofactor, pyridoxal phosphate. Yorifuji T, Ogata K, Soda K (1969). "Crystalline arginine racemase". Biochem. ...
https://en.wikipedia.org/wiki/Arginine_racemase
DTDP-4-amino-4,6-dideoxy-D-glucose transaminaseDTDP-4-amino-4,6-dideoxy-D-glucose transaminase
Portal: Biology v t e (EC 2.6.1, Pyridoxal phosphate enzymes, Enzymes of unknown structure, All stub articles, EC 2.6 stubs). ... It employs one cofactor, pyridoxal phosphate. Matsuhashi M, Strominger JL (1966). "Thymidine diphosphate 4-acetamido-2,6- ...
https://en.wikipedia.org/wiki/DTDP-4-amino-4,6-dideoxy-D-glucose_transaminase
1-Aminocyclopropane-1-carboxylate synthase1-Aminocyclopropane-1-carboxylate synthase
source) It is a pyridoxal phosphate (PLP) dependent gamma-elimination (?). In the gamma elimination, PLP acts as a sink twice ( ... They are natural toxins that cause slow binding inhibition by interfering with the coenzyme pyridoxal phosphate. ACC synthase ... It employs one cofactor, pyridoxal phosphate. The reaction catalyzed by 1-aminocyclopropane-1-carboxylic acid synthase (ACS) is ... Portal: Biology (CS1: long volume value, EC 4.4.1, Pyridoxal phosphate enzymes, Enzymes of known structure). ...
https://en.wikipedia.org/wiki/1-Aminocyclopropane-1-carboxylate_synthase
Glutamine-scyllo-inositol transaminaseGlutamine-scyllo-inositol transaminase
Portal: Biology v t e (EC 2.6.1, Pyridoxal phosphate enzymes, Enzymes of unknown structure, All stub articles, EC 2.6 stubs). ... It employs one cofactor, pyridoxal phosphate. Walker JB, Walker MS (1969). "Streptomycin biosynthesis. Transamination reactions ...
https://en.wikipedia.org/wiki/Glutamine—scyllo-inositol_transaminase
Glutamate-1-semialdehyde 2,1-aminomutaseGlutamate-1-semialdehyde 2,1-aminomutase
Portal: Biology v t e (EC 5.4.3, Pyridoxal phosphate enzymes, Enzymes of known structure, All stub articles, Isomerase stubs). ... It employs one cofactor, pyridoxal phosphate. As of late 2007, 10 structures have been solved for this class of enzymes, with ...
https://en.wikipedia.org/wiki/Glutamate-1-semialdehyde_2,1-aminomutase
Aminolevulinate transaminaseAminolevulinate transaminase
Portal: Biology v t e (EC 2.6.1, Pyridoxal phosphate enzymes, Enzymes of unknown structure, All stub articles, EC 2.6 stubs). ... It employs one cofactor, pyridoxal phosphate. Gibson KD, Matthew M, Neuberger A (1961). "Biosynthesis of porphyrins and ...
https://en.wikipedia.org/wiki/Aminolevulinate_transaminase
Amino-acid racemaseAmino-acid racemase
Portal: Biology v t e (EC 5.1.1, Pyridoxal phosphate enzymes, Enzymes of known structure, All stub articles, Isomerase stubs). ... It employs one cofactor, pyridoxal phosphate. As of late 2007, 5 structures have been solved for this class of enzymes, with ...
https://en.wikipedia.org/wiki/Amino-acid_racemase
Glycine C-acetyltransferaseGlycine C-acetyltransferase
Portal: Biology v t e (EC 2.3.1, Pyridoxal phosphate enzymes, Enzymes of known structure, All stub articles, EC 2.3 stubs). ... It employs one cofactor, pyridoxal phosphate. As of late 2007, only one structure has been solved for this class of enzymes, ...
https://en.wikipedia.org/wiki/Glycine_C-acetyltransferase
ATC code A11ATC code A11
A11HA05 Biotin A11HA06 Pyridoxal phosphate A11HA07 Inositol A11HA08 Tocofersolan A11HA30 Dexpanthenol A11HA31 Calcium ...
https://en.wikipedia.org/wiki/ATC_code_A11
D-ornithine 4,5-aminomutaseD-ornithine 4,5-aminomutase
Portal: Biology v t e (EC 5.4.3, Pyridoxal phosphate enzymes, Enzymes of unknown structure, All stub articles, Isomerase stubs) ... Somack R, Costilow RN (1973). "Purification and properties of a pyridoxal phosphate and coenzyme B 12 dependent D- -ornithine 5 ... It has 3 cofactors: pyridoxal phosphate, Cobamide coenzyme, and Dithiothreitol. ...
https://en.wikipedia.org/wiki/D-ornithine_4,5-aminomutase
Glycogen phosphorylaseGlycogen phosphorylase
... has a pyridoxal phosphate (PLP, derived from Vitamin B6) at each catalytic site. Pyridoxal phosphate ... the phosphate group on the PLP readily donates a proton to an inorganic phosphate molecule, allowing the inorganic phosphate to ... Palm D, Klein HW, Schinzel R, Buehner M, Helmreich EJ (February 1990). "The role of pyridoxal 5'-phosphate in glycogen ... Glycogenolysis PDB: 3E3N​ Livanova NB, Chebotareva NA, Eronina TB, Kurganov BI (October 2002). "Pyridoxal 5'-phosphate as a ...
https://en.wikipedia.org/wiki/Glycogen_phosphorylase
Adenosylmethionine decarboxylaseAdenosylmethionine decarboxylase
... phosphate. These proteins can be divided into two main groups which show little sequence similarity either to each other, or to ... amino acid decarboxylases AdoMetDC uses a covalently bound pyruvate residue as a cofactor rather than the more common pyridoxal ...
https://en.wikipedia.org/wiki/Adenosylmethionine_decarboxylase
MelatoninMelatonin
A decarboxylase with cofactor pyridoxal phosphate (PLP) removes CO2 from 5-hydroxy-L-tryptophan to produce 5-hydroxytryptamine ... This intermediate (5-HTP) is decarboxylated by pyridoxal phosphate and 5-hydroxytryptophan decarboxylase to produce serotonin. ... In these cells, synthesis starts with D-erythrose 4-phosphate and phosphoenolpyruvate, and in photosynthetic cells with carbon ...
https://en.wikipedia.org/wiki/Melatonin
Threo-3-hydroxy-D-aspartate ammonia-lyaseThreo-3-hydroxy-D-aspartate ammonia-lyase
NH3 This enzyme is a pyridoxal-phosphate protein. Maeda T, Takeda Y, Murakami T, Yokota A, Wada M (December 2010). " ...
https://en.wikipedia.org/wiki/Threo-3-hydroxy-D-aspartate_ammonia-lyase
Serine racemaseSerine racemase
Mammalian serine racemase is a pyridoxal 5'-phosphate dependent enzyme that catalyzes both the racemization of L-serine to D- ... The canonical tetraglycine loop that serves as a PLP phosphate binding pocket includes the active residues being F55, K56, G185 ...
https://en.wikipedia.org/wiki/Serine_racemase
Alpha glucanAlpha glucan
... interrelationship between the polysaccharide and pyridoxal phosphate binding sites by affinity electrophoresis". Biochemistry. ...
https://en.wikipedia.org/wiki/Alpha_glucan
Indoleacetaldoxime dehydrataseIndoleacetaldoxime dehydratase
KUMAR SA, MAHADEVAN S (1963). "3-INDOLEACETALDOXIME HYDRO-LYASE: A PYRIDOXAL-5'-PHOSPHATE ACTIVATED ENZYME". Arch. Biochem. ...
https://en.wikipedia.org/wiki/Indoleacetaldoxime_dehydratase
Transsulfuration pathwayTranssulfuration pathway
All four transsulfuration enzymes require vitamin B6 in its active form (pyridoxal phosphate or PLP). Three of these enzymes ( ... Clausen, T.; Huber, R.; Laber, B.; Pohlenz, H. D.; Messerschmidt, A. (1996). "Crystal Structure of the Pyridoxal-5′-phosphate ...
https://en.wikipedia.org/wiki/Transsulfuration_pathway
2,3-Diaminopropionic acid2,3-Diaminopropionic acid
2,3-Diaminopropionate is formed by the pyridoxal phosphate (PLP) mediated amination of serine. Frenkel-Pinter M, Haynes JW, C M ...
https://en.wikipedia.org/wiki/2,3-Diaminopropionic_acid
Cystathionine beta synthaseCystathionine beta synthase
... a unique pyridoxal 5'-phosphate-dependent heme protein". The EMBO Journal. 20 (15): 3910-6. doi:10.1093/emboj/20.15.3910. PMC ... H2O CBS uses the cofactor pyridoxal-phosphate (PLP) and can be allosterically regulated by effectors such as the ubiquitous ... Pyridoxal phosphate enzymes, Enzymes of known structure). ...
https://en.wikipedia.org/wiki/Cystathionine_beta_synthase
Alanine transaminaseAlanine transaminase
... require the coenzyme pyridoxal phosphate, which is converted into pyridoxamine in the first phase of the reaction, when an ...
https://en.wikipedia.org/wiki/Alanine_transaminase
AKR1B1AKR1B1
Affinity labeling of an active site lysine by pyridoxal 5'-phosphate and pyridoxal 5'-diphospho-5'-adenosine". The Journal of ... It is a reduced nicotinamide-adenine dinucleotide phosphate (NADPH)-dependent enzyme catalyzing the reduction of various ... It is a reduced nicotinamide-adenine dinucleotide phosphate (NADPH)-dependent enzyme catalyzing the reduction of various ...
https://en.wikipedia.org/wiki/AKR1B1
Lysine 2,3-aminomutaseLysine 2,3-aminomutase
Pyridoxal phosphate (PLP): Responsible for binding of the amino acid during reaction. The pi-system of this molecule ... In this configuration, the radical is stabilized by the pi-system of pyridoxal phosphate. Amino Acid Conversion: In the final ... Enzyme Binding: Lysine 2,3-aminomutase binds to pyridoxal phosphate (PLP). Amino Acid Binding: The amino acid (Lysine or Beta- ... binds to pyridoxal phosphate. Radical Transfer: The 5'-deoxyadenosyl radical is transferred to the amino acid and an aziridinyl ...
https://en.wikipedia.org/wiki/Lysine_2,3-aminomutase
UDP-4-amino-4-deoxy-L-arabinose aminotransferaseUDP-4-amino-4-deoxy-L-arabinose aminotransferase
L-glutamate This protein is a pyridoxal 5'-phosphate enzyme. Breazeale SD, Ribeiro AA, Raetz CR (July 2003). "Origin of lipid A ...
https://en.wikipedia.org/wiki/UDP-4-amino-4-deoxy-L-arabinose_aminotransferase
Serine hydroxymethyltransferaseSerine hydroxymethyltransferase
... (SHMT) is a pyridoxal phosphate (PLP) (Vitamin B6) dependent enzyme (EC 2.1.2.1) which plays an ... April 2015). "How pyridoxal 5'-phosphate differentially regulates human cytosolic and mitochondrial serine ... 31P nuclear magnetic resonance study of the enzyme-bound pyridoxal 5'-phosphate". The Journal of Biological Chemistry. 258 (1 ... which is induced by Pyridoxal phosphate, has recently been shown to be involved in regulation of the BRISC deubiqutylase ...
https://en.wikipedia.org/wiki/Serine_hydroxymethyltransferase
GOT1GOT1
Glutamic-oxaloacetic transaminase is a pyridoxal phosphate-dependent enzyme which exists in cytoplasmic and mitochondrial forms ...
https://en.wikipedia.org/wiki/GOT1
Selenocysteine lyaseSelenocysteine lyase
Portal: Biology v t e (EC 4.4.1, Pyridoxal phosphate enzymes, Enzymes of known structure, All stub articles, Enzyme stubs). ...
https://en.wikipedia.org/wiki/Selenocysteine_lyase
Pyridoxine 5′-phosphate oxidasePyridoxine 5′-phosphate oxidase
... pyridoxal 5′-phosphate + NH3 + H2O2 pyridoxine phosphate + O2 ⇌ H2O2 + pyridoxal phosphate Pyridoxine 5′-phosphate oxidase also ... Pyridoxal 5′-phosphate is an effective product inhibitor. Since pyridoxal 5′-phosphate, the active form of vitamin B6, is the ... phosphate substrate, whereas the pyridoxine 5′-phosphate oxidase in E. coli has a higher specificity pyridoxal 5′-phosphate ... Pyridoxine 5′-phosphate oxidase catalyzes the final, rate-limiting step in vitamin B6 metabolism, the biosynthesis of pyridoxal ...
https://en.wikipedia.org/wiki/Pyridoxine_5′-phosphate_oxidase
D-lysine 5,6-aminomutaseD-lysine 5,6-aminomutase
Maity AN, Lin H, Chiang H, Lo H, Ke S (May 2015). "Reaction of Pyridoxal-5′-phosphate-N-oxide with Lysine 5,6-Aminomutase: ... 5,6-LAM is pyridoxal-5'-phosphate (PLP) dependent. PLP binds to its substrate with an external aldimine linkage. PLP is also ...
https://en.wikipedia.org/wiki/D-lysine_5,6-aminomutase
Pyridoxal phosphate - WikipediaPyridoxal phosphate - Wikipedia
Pyridoxal phosphate (PLP, pyridoxal 5-phosphate, P5P), the active form of vitamin B6, is a coenzyme in a variety of enzymatic ... Pyridoxal phosphate is a cofactor of ornithine carboxylase.. *Transamination. Pyridoxal phosphate takes part in decomposition ... The condensation product of 3-hydroxy-1-aminoacetone phosphate and deoxyxylulose 5-phosphate is pyridoxine 5-phosphate. The ... Pyridoxal phosphate has numerous roles in human body. A few examples below: *Metabolism and biosynthesis of serotonin. ...
https://en.wikipedia.org/wiki/Pyridoxal_phosphate
Pyridoxal 5-phosphate-dependent epilepsy: MedlinePlus GeneticsPyridoxal 5'-phosphate-dependent epilepsy: MedlinePlus Genetics
... phosphate-dependent epilepsy is a condition that involves seizures beginning soon after birth or, in some cases, before birth. ... medlineplus.gov/genetics/condition/pyridoxal-5-phosphate-dependent-epilepsy/ Pyridoxal 5-phosphate-dependent epilepsy. ... Pyridoxal 5-phosphate-dependent epilepsy is a condition that involves seizures beginning soon after birth or, in some cases, ... Mutations in the PNPO gene cause pyridoxal 5-phosphate-dependent epilepsy. The PNPO gene provides instructions for producing ...
https://medlineplus.gov/genetics/condition/pyridoxal-5-phosphate-dependent-epilepsy/
RCSB PDB - 1AKA: STRUCTURAL BASIS FOR THE CATALYTIC ACTIVITY OF ASPARTATE AMINOTRANSFERASE K258H LACKING ITS PYRIDOXAL-5...RCSB PDB - 1AKA: STRUCTURAL BASIS FOR THE CATALYTIC ACTIVITY OF ASPARTATE AMINOTRANSFERASE K258H LACKING ITS PYRIDOXAL-5'...
STRUCTURAL BASIS FOR THE CATALYTIC ACTIVITY OF ASPARTATE AMINOTRANSFERASE K258H LACKING ITS PYRIDOXAL-5-PHOSPHATE-BINDING ... PYRIDOXAL-5-PHOSPHATE. C8 H10 N O6 P. NGVDGCNFYWLIFO-UHFFFAOYSA-N. Ligand Interaction. ... STRUCTURAL BASIS FOR THE CATALYTIC ACTIVITY OF ASPARTATE AMINOTRANSFERASE K258H LACKING ITS PYRIDOXAL-5-PHOSPHATE-BINDING ... Structural basis for the catalytic activity of aspartate aminotransferase K258H lacking the pyridoxal 5-phosphate-binding ...
https://www.rcsb.org/structure/1AKA
Pyridoxal 5-Phosphate Caps- My Village GreenPyridoxal 5'-Phosphate Caps- My Village Green
By inhibiting these reactions and working as a coenzyme in biochemical reactions, pyridoxal 5-phosphate can support ... Pyridoxal 5ˈ-phosphate is the metabolically active form of vitamin B6. It plays a crucial role in a number of life processes ... Pyridoxal 5ˈ-phosphate is the metabolically active form of vitamin B6. It plays a crucial role in a number of life processes ... By inhibiting these reactions and working as a coenzyme in biochemical reactions, pyridoxal 5-phosphate can support healthy ...
https://myvillagegreen.com/products/pyridoxal-5-phosphate-caps
Journal name: Biochimica et biophysica acta / Subject: spectroscopy and pyridoxal phosphate - PubAg Search ResultsJournal name: Biochimica et biophysica acta / Subject: spectroscopy and pyridoxal phosphate - PubAg Search Results
... pyridoxal phosphate Remove constraint Subject: pyridoxal phosphate Start Over ... biosynthesis; pyridoxal phosphate; sphingolipids; spectroscopy; enzymology; serine C-palmitoyltransferase. Abstract:. ... ...
https://pubag.nal.usda.gov/?f%5Bjournal_name%5D%5B%5D=Biochimica+et+biophysica+acta&f%5Bsubject_facet%5D%5B%5D=spectroscopy&f%5Bsubject_facet%5D%5B%5D=pyridoxal+phosphate&per_page=50&search_field=subject&sort=date-desc
ENZYME - 4.3.3.6 pyridoxal 5-phosphate synthase (glutamine hydrolyzing)ENZYME - 4.3.3.6 pyridoxal 5'-phosphate synthase (glutamine hydrolyzing)
D-glyceraldehyde 3-phosphate + L-glutamine <=> H(+) + 3 H2O + L-glutamate + phosphate + pyridoxal 5-phosphate. ... The enzyme can also use ribulose 5-phosphate and dihydroxyacetone phosphate. *The enzyme complex is found in aerobic bacteria, ...
https://enzyme.expasy.org/EC/4.3.3.6
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pyridoxal phosphate binding | NIH 3D Print Exchangepyridoxal phosphate binding | NIH 3D Print Exchange
pyridoxal phosphate binding, cystathionine beta-lyase, LYASE, INHIBITOR, COMPLEX, L-cycloserine, external aldimine ...
https://3dprint.nih.gov/discover/pyridoxal-phosphate-binding
pyridoxal 5 phosphate | Phoenix Rising ME/CFS Forumspyridoxal 5 phosphate | Phoenix Rising ME/CFS Forums
... phosphate) 100 mg. The Source Naturals products label says Vitamin B6 60 mg (from 100 mg pyridoxal-5-phosphate). Both ... The Life Extension products label says Vitamin B6 (as pyridoxal-5- ...
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NHANES 2007-2008: Vitamin B6 Data Documentation, Codebook, and Frequencies
... phosphate (nmol/L). Variable Name: LBXPLP. SAS Label: Pyridoxal 5-phosphate (nmol/L). English Text: Pyridoxal 5-phosphate ( ... Pyridoxal 5-phosphate (Vitamin B6) for 2005-2006 and 2003-2004:. There was a change in pyridoxal 5-phosphate (Vitamin B6) ... In 2003-2004, plasma pyridoxal 5-phosphate (PLP) was performed using a homogeneous, enzymatic assay by A/C Diagnostics. In ...
https://wwwn.cdc.gov/Nchs/Nhanes/2007-2008/VIT_B6_E.htm
Thorne Research Pyridoxal 5 PhosphateThorne Research Pyridoxal 5' Phosphate
Thorne Research Pyridoxal 5 Phosphate aides in energy production and healthy bodily functions. ... Thorne Research Pyridoxal 5 Phosphate is the bioactive form of Vitamin B6. ... There have been no case reports of neuropathies with pyridoxal 5-phosphate use. ...
https://supplementfirst.com/products/thorne-research-pyridoxal-5-phosphate
Vitamin B6 (Pyridoxal-5-Phosphate) - Akua LifeVitamin B6 (Pyridoxal-5-Phosphate) - Akua Life
Pyridoxal 5-Phosphate 180 vegcaps - DrGina.comPyridoxal 5'-Phosphate 180 vegcaps - DrGina.com
Phosphate is vitamin B6 in its most bioactive and readily usable form.* Vitamin B6 pairs with magnesium for support of women ... Pyridoxal 5-Phosphate is vitamin B6 in its most bioactive and readily usable form.* Vitamin B6 pairs with magnesium for ... Pyridoxal 5-Phosphate is vitamin B6 in its most bioactive and readily usable form.* Vitamin B6 pairs with magnesium for ... Pyridoxal 5-phosphate (P5P) is also necessary for homocysteine recycling because it helps facilitate the break-down of ...
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Pyridoxal 5-phosphate monohydrate [CAS: 41468-25-1] Pyridoxal 5'-phosphate monohydrate [CAS: 41468-25-1]
Pyridoxal 5-phosphate monohydrate [CAS: 41468-25-1]
http://ivychem.com/prod.php?id=10815
Pyridoxal 5-Phosphate - Down to Earth Wellness CenterPyridoxal 5'-Phosphate - Down to Earth Wellness Center
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Pyridoxal 5-Phosphate 180 caps - Dr. Jill Health StorePyridoxal 5-Phosphate 180 caps - Dr. Jill Health Store
Vitamin B6 (Pyridoxal 5′-Phosphate). 33.8mg. Other Ingredients: Calcium Laurate, Hypromellose Capsule, Microcrystalline ... Supplementing with Thornes Pyridoxal 5′-Phosphate ensures the most bioactive form of vitamin B6 is being supplemented.* This ... Pyridoxal 5′-phosphate (P5P) is also necessary for homocysteine recycling because it facilitates the break-down of homocysteine ... pyridoxine must be converted to pyridoxal 5′-phosphate (P5P).* Some individuals who have compromised liver function have ...
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99% Pharma Pyridoxal - 5 Phosphate Monohydrate CAS 41468-25-199% Pharma Pyridoxal - 5 Phosphate Monohydrate CAS 41468-25-1
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Source Naturals Melatonin Lozenges Orange -- 2.5 mg - 240 Lozenges - VitacostSource Naturals Melatonin Lozenges Orange -- 2.5 mg - 240 Lozenges - Vitacost
Vitamin B6 (as pyridoxal-5-phosphate [Coenzymated]). 335 mcg. 20%. Melatonin. 2.5 mg. * ...
https://www.vitacost.com/source-naturals-melatonin-lozenges-orange
Life Extension Pyridoxal 5-Phosphate 100 Mg Vegetarian Capsules, 60-CountLife Extension Pyridoxal 5-Phosphate 100 Mg Vegetarian Capsules, 60-Count
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P5P Vitamin B6 50mg | 250 Tablets | Pyridoxal 5 Phosphate and Coenzyme - Carlyle NutritionalsP5P Vitamin B6 50mg | 250 Tablets | Pyridoxal 5 Phosphate and Coenzyme - Carlyle Nutritionals
Pyridoxal-5-Phosphate) is the active form of Vitamin B6. This essential nutrient is naturally found in nutritious fruits and ... P5P Vitamin B6 50mg , 250 Tablets , Pyridoxal 5 Phosphate and Coenzyme B6. Regular price Sale price $14.99 Unit price / per ... Commonly known as Coenzyme B6, P-5-P (Pyridoxal-5-Phosphate) is the active form of Vitamin B6. This essential nutrient is ...
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Humira and Arthralgia - Suspected Cause - Reports of Side EffectsHumira and Arthralgia - Suspected Cause - Reports of Side Effects
Other drugs received by patient: Pyridoxal Phosphate Hydrate; Pyridoxal Phosphate Hydrate; Etodolac; Sulfasalazine; Folic Acid ...
http://www.druglib.com/reported-side-effects/humira/reaction_arthralgia/
IMSEAR at SEARO: Interactions of methoxyamine with pyridoxal-5'-phosphate-Schiff's base at the active site of sheep liver...
Interactions of methoxyamine with pyridoxal-5-phosphate-Schiffs base at the active site of sheep liver serine ... Interactions of methoxyamine with pyridoxal-5-phosphate-Schiffs base at the active site of sheep liver serine ...
https://imsear.searo.who.int/handle/123456789/28628?locale=en
Diabetic Neuropathy Clinical Presentation: History, Physical Examination, Classification of Diabetic NeuropathyDiabetic Neuropathy Clinical Presentation: History, Physical Examination, Classification of Diabetic Neuropathy
2010metanx-l-methylfolate-pyridoxal-5-phosphate-methylcobalamin-999834Drugs. Drugs L-methylfolate/pyridoxal 5-phosphate/ ...
https://www.medscape.com/answers/1170337-4975/how-is-diabetic-neuropathy-staged
B vitamin blood concentrations and one-carbon metabolism polymorphisms in a sample of Italian women and men attending a unit of...B vitamin blood concentrations and one-carbon metabolism polymorphisms in a sample of Italian women and men attending a unit of...
... pyridoxal 5′-phosphate (PLP), as well as that of homocysteine (tHcy). One-carbon metabolism-related genes should be also taken ...
https://link.springer.com/article/10.1007/s00394-020-02448-1
Vital Nutrients P-5-P Pyridoxal-5-Phosphate 50 mg 90 caps - Apex Pharmacy and Nutrition CenterVital Nutrients P-5-P Pyridoxal-5-Phosphate 50 mg 90 caps - Apex Pharmacy and Nutrition Center
PYRIDOXAL 5 PHOSPHATE (P5P or ACTIVATED VITAMIN B6) is required to metabolize proteins, carbohydrates, and fats and is ... Vital Nutrients P-5-P Pyridoxal-5-Phosphate 50 mg 90 caps - ... Vital Nutrients Pyridoxal 5 Phosphate ( P-5-P) 50 mcg 90 caps. ... Pyridoxal 5 Phosphate contains per capsule:. Pyridoxal 5 phosphate (activated vitamin B-6). 50mg. ... PYRIDOXAL 5 PHOSPHATE (P5P or ACTIVATED VITAMIN B6) is required to metabolize proteins, carbohydrates, and fats and is ...
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Jarrow Formulas, Inc. Methyl B-12 & Methyl Folate + P-5-P - Cherry 60 Chwbls - Swanson®Jarrow Formulas, Inc. Methyl B-12 & Methyl Folate + P-5-P - Cherry 60 Chwbls - Swanson®
Vitamin B6 (as pyridoxal-5-phosphate) 2.5 mg. 150%. Folate 1,360 mcg DFE† ...
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PYRIDOXAL-5-PHOSPHATE 75 MG - 90 CAPS : PURELY YOURS - VITAMINS - VITAMINS B-C - VITAMIN B6 - OMNICARE EXPRESS SARL
90 capsules contain 75 mg of pyridoxal-5-phosphate, the active form of vitamin B6. ... 90 capsules contain 75 mg of pyridoxal-5-phosphate, the active form of vitamin B6. ...
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Ischemic Monomelic Neuropathy Treatment & Management: Approach Considerations, Physical and Occupational TherapyIschemic Monomelic Neuropathy Treatment & Management: Approach Considerations, Physical and Occupational Therapy
2010metanx-l-methylfolate-pyridoxal-5-phosphate-methylcobalamin-999834Drugs. Drugs L-methylfolate/pyridoxal 5-phosphate/ ...
https://emedicine.medscape.com/article/315915-treatment
DHA 40%w/w + Pyridoxal-5 Phosphate 500mcg L-Methylfolate 800mcg + Methylcobalamin 1500mcg - DHA 40%w/w + Pyridoxal-5...DHA 40%w/w + Pyridoxal-5 Phosphate 500mcg L-Methylfolate 800mcg + Methylcobalamin 1500mcg - DHA 40%w/w + Pyridoxal-5...
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FolateRiboflavinCoenzymeMethylcobalaminEnzymesPyridoxamineBioactiveAminotransferaseDihydroxyacetone phosphateAmino acidsCofactorHomocysteineFormSubstrateEnzymaticEpilepticEpilepsyAssayReactionRolesLiverProteinMetabolizeRiboflavin-5-phosphaFolateDEFICIENCYOxidaseKnown as pyridoxal 5-phosphaLevels of pyridoxal-phosphateProteinPhosphataseBiotinCofactor pyridoxalCombination of pyridoxinePyridoxamine phosphateNeonatalInositolSeizuresPhosphorylationProteinsDependent enzymesGeneAcidTransaminasesKinasePhysiologicalZinc
Folate2
  • Considering the interest of defining B vitamins intake with the diet for a clear definition of dietary policies together with the possible indication of supplement use, it is important to measure in a sample of healthy men and women, their plasma levels of folate and other major B vitamins, namely B12 and the active form of vitamin B6, pyridoxal 5′-phosphate (PLP), as well as that of homocysteine (tHcy). (springer.com)
  • This includes methylcobalamin (active B12), methyl folate as 5-MTHF - Quatrefolic®, and pyridoxal 5' phosphate (active B6). (glutenfreesociety.org)
Riboflavin1
  • ThorneVet's Basic B Complex contains the entire B-complex, including the activated forms of vitamin B2 (riboflavin 5'-phosphate), vitamin B6 (pyridoxal 5'-phosphate), folic acid (folinic acid and L-5-methyl-tetrahydrofolate), and vitamin B12 (adenosylcobalamin and methylcobalamin), as well as 80 mg choline citrate. (onlynaturalpet.com)
Coenzyme5
  • Pyridoxal phosphate ( PLP , pyridoxal 5'- phosphate , P5P ), the active form of vitamin B 6 , is a coenzyme in a variety of enzymatic reactions. (wikipedia.org)
  • By inhibiting these reactions and working as a coenzyme in biochemical reactions, pyridoxal 5'-phosphate can support healthy nerve, eye, cardiovascular and kidney function. (myvillagegreen.com)
  • Commonly known as Coenzyme B6, P-5-P (Pyridoxal-5-Phosphate) is the active form of Vitamin B6. (carlylenutritionals.com)
  • For example, the coenzyme of aminotransferase is pyridoxal phosphate. (articlesfactory.com)
  • NAC also helps boost cellular levels of Glutathione, along with hard to find S-Acetyl Glutathione and synergist Pyridoxal 5'-Phosphate (P5P), the active coenzyme form of Vitamin B6. (tryunity.net)
Methylcobalamin1
  • Walker MJ Jr, Morris LM, Cheng D. Improvement of cutaneous sensitivity in diabetic peripheral neuropathy with combination L-methylfolate, methylcobalamin, and pyridoxal 5'-phosphate. (medscape.com)
Enzymes4
  • I reflect on my research on pyridoxal phosphate (PLP) enzymes over fifty-five years and on how I combined research with marriage and family. (jbc.org)
  • Evolutionary Relationships between Pyridoxal-5'-Phosphate Dependent Enzymes. (expasy.org)
  • The MocR proteins possess an N-terminal domain containing the winged Helix-Turn-Helix (wHTH) motif and a C-terminal domain whose architecture is homologous to the fold type-I pyridoxal 5'-phosphate (PLP) dependent enzymes whose archetypical protein is aspartate amino transferase (AAT). (bioinformation.net)
  • A group of enzymes that transfers a phosphate group onto an alcohol group acceptor. (nih.gov)
Pyridoxamine5
  • [6] In these reactions, the PLP reacts with glutamate , which transfers its alpha-amino group to PLP to make pyridoxamine phosphate (PMP). (wikipedia.org)
  • This enzyme is involved in the conversion (metabolism) of vitamin B6 derived from food (in the form of pyridoxine and pyridoxamine) to the active form of vitamin B6 called pyridoxal 5'-phosphate (PLP). (medlineplus.gov)
  • PNPO gene mutations result in a pyridoxine 5'-phosphate oxidase enzyme that is unable to metabolize pyridoxine and pyridoxamine, leading to a deficiency of PLP. (medlineplus.gov)
  • In the process of transamination, the transferred amino group first combines with pyridoxal phosphate to form pyridoxamine phosphate, and then pyridoxamine phosphate transfers this amino group to another substance. (articlesfactory.com)
  • During transamination of amino acids, pyridoxal phosphate is transiently converted into pyridoxamine phosphate ( PYRIDOXAMINE ). (bvsalud.org)
Bioactive4
  • Thorne Research Pyridoxal 5' Phosphate is the bioactive form of Vitamin B6. (supplementfirst.com)
  • Pyridoxal 5'-Phosphate is vitamin B6 in its most bioactive and readily usable form. (drgina.com)
  • Supplementing with Thorne's Pyridoxal 5′-Phosphate ensures the most bioactive form of vitamin B6 is being supplemented. (drjillhealth.com)
  • Make sure to look for vitamin B sources in their bioactive forms, like instead of plain old vitamin B6, if your manufacturer cares about you, the label will say pyridoxal-5-phosphate, the bioactive form. (pureprescriptions.com)
Aminotransferase2
  • Pyridoxal phosphate also participates in the oxidative deamination of GABA, where it is a cofactor of GABA aminotransferase. (wikipedia.org)
  • Mutant Aspartate Aminotransferase (K258H) without Pyridoxal-5'-Phosphate-Binding Lysine Residue. (rcsb.org)
Dihydroxyacetone phosphate2
  • The enzyme can also use ribulose 5-phosphate and dihydroxyacetone phosphate. (expasy.org)
  • It catalyzes the cleavage of fructose 1,6-diphosphate into glyceraldehyde phosphate and dihydroxyacetone phosphate. (articlesfactory.com)
Amino acids2
  • Pyridoxal phosphate is a cofactor of aromatic L-amino acids decarboxylase . (wikipedia.org)
  • Pyridoxal phosphate takes part in decomposition and synthesis of amino acids . (wikipedia.org)
Cofactor2
  • Pyridoxal phosphate is a cofactor of glutamic acid decarboxylase (GAD). (wikipedia.org)
  • Pyridoxal phosphate is a cofactor of ornithine carboxylase. (wikipedia.org)
Homocysteine1
  • Pyridoxal 5'-phosphate (P5P) is also necessary for homocysteine recycling because it helps facilitate the break-down of homocysteine to taurine and cysteine. (drgina.com)
Form4
  • Instead, individuals with this type of epilepsy are medically treated with large daily doses of pyridoxal 5'-phosphate (a form of vitamin B6). (medlineplus.gov)
  • Pyridoxal 5ˈ-phosphate is the metabolically active form of vitamin B6. (myvillagegreen.com)
  • 90 capsules contain 75 mg of pyridoxal-5-phosphate, the active form of vitamin B6. (omnicareexpress.com)
  • Low levels of pyridoxal-5-phosphate (PLP), the active form of vitamin B6, have been measured in patients with cardiovascular disease, rheumatoid arthritis, inflammatory bowel disease, and diabetes. (mdcurrent.in)
Substrate1
  • The result, replacement in a retention mode, together with the finding that tritium from the alpha-position of the substrate is recycled and appears both at C alpha and C beta of the product suggests a single base mechanism and an active site geometry of the pyridoxal phosphate- substrate complex in which H alpha and the beta-substituent are syn oriented. (unipr.it)
Enzymatic1
  • In 2003-2004, plasma pyridoxal 5'-phosphate (PLP) was performed using a homogeneous, enzymatic assay by A/C Diagnostics. (cdc.gov)
Epileptic2
  • Pyridoxal phosphate-dependent neonatal epileptic encephalopathy. (medlineplus.gov)
  • Neonatal epileptic encephalopathy caused by mutations in the PNPO gene encoding pyridox(am)ine 5'-phosphate oxidase. (medlineplus.gov)
Epilepsy4
  • Pyridoxal 5'-phosphate-dependent epilepsy is a condition that involves seizures beginning soon after birth or, in some cases, before birth. (medlineplus.gov)
  • Anticonvulsant drugs, which are usually given to control seizures, are ineffective in people with pyridoxal 5'-phosphate-dependent epilepsy. (medlineplus.gov)
  • Mutations in the PNPO gene cause pyridoxal 5'-phosphate-dependent epilepsy. (medlineplus.gov)
  • It is not clear how the lack of PLP affects the brain and leads to the seizures that are characteristic of pyridoxal 5'-phosphate-dependent epilepsy. (medlineplus.gov)
Assay1
  • Vitamin-B6 status was evaluated using the erythrocyte glutamic-pyruvic-transaminase (EGPT) assay and quantification of plasma pyridoxal-5'-phosphate. (cdc.gov)
Reaction1
  • However, this enzyme does not exploit the reactive aldehyde group, but instead utilizes the phosphate group on PLP to perform its reaction. (wikipedia.org)
Roles1
  • Pyridoxal phosphate has numerous roles in human body. (wikipedia.org)
Liver1
  • IMSEAR at SEARO: Interactions of methoxyamine with pyridoxal-5'-phosphate-Schiff's base at the active site of sheep liver serine hydroxymethyltransferase. (who.int)
Protein1
  • Pyridoxal phosphate biosynthetic protein PdxA [Interproscan]. (ntu.edu.sg)
Metabolize1
  • PYRIDOXAL 5' PHOSPHATE (P5P or ACTIVATED VITAMIN B6) is required to metabolize proteins, carbohydrates, and fats and is important in the production of antibodies and red blood cells. (theapexstore.com)
Riboflavin-5-phospha3
  • also known as riboflavin-5'-phosphate) and flavin adenine dinucleotide (FAD). (nih.gov)
  • It is now enhanced with vitamin B2 as riboflavin-5-phosphate, Setria® glutathione, zinc, and increased amounts of activated pyridoxal-5'-phosphate. (nutricology.com)
  • Provides activated B vitamins, including pyridoxal-5-phosphate, riboflavin-5-phosphate, enhanced-retention thiamin derivative benfotiamine and 800 mcg of Metafolin L-5-methyltetrahydrofolate (L-5-MTHF), the naturally occurring, universally metabolized form of folate. (vitaminsuite.com)
Folate1
  • It provides the primary nutrients known to be necessary for the breakdown of homocysteine into methionine and other metabolites, including vitamin B6 as pyridoxine and pyridoxal-5'-phosphate (P5P), vitamin B12 as methylcobalamin, folate as 5-methyltetrahydrofolate (5-MTHF), trimethylglycine (TMG), and L-serine. (nutricology.com)
DEFICIENCY6
  • PNPO gene mutations result in a pyridoxine 5'-phosphate oxidase enzyme that is unable to metabolize pyridoxine and pyridoxamine, leading to a deficiency of PLP. (medlineplus.gov)
  • Systemic Manifestations in Pyridox(am)ine 5'-Phosphate Oxidase Deficiency. (nih.gov)
  • Pyridoxal 5'-phosphate, with regard to humans, has been found to be associated with several diseases such as epilepsy, early-onset, vitamin B6-dependent, odontohypophosphatasia, pyridoxamine 5-prime-phosphate oxidase deficiency, and hypophosphatasia. (hmdb.ca)
  • Phenotypic and molecular spectrum of pyridoxamine-5'-phosphate oxidase deficiency: A scoping review of 87 cases of pyridoxamine-5'-phosphate oxidase deficiency. (nih.gov)
  • Strictly speaking, there is no such thing as a recommended pyridoxal 5-phosphate dosage or a pyridoxal 5-phosphate deficiency, since our bodies make this specific chemical. (healthifybody.com)
  • Furthermore, the EGRAC cannot be used in people with glucose-6-phosphate dehydrogenase deficiency, which is present in about 10% of African Americans [ 8 ]. (nih.gov)
Oxidase6
  • The PNPO gene provides instructions for producing an enzyme called pyridoxine 5'-phosphate oxidase. (medlineplus.gov)
  • Neonatal epileptic encephalopathy caused by mutations in the PNPO gene encoding pyridox(am)ine 5'-phosphate oxidase. (medlineplus.gov)
  • Pyridox(am)ine-5'-phosphate oxidase converts pyridoxine phosphate and pyridoxamine phosphate to pyridoxal phosphate, a cofactor in many metabolic reactions, including neurotransmitter synthesis. (nih.gov)
  • A family with a mutation in the pyridox(am)ine-5'-phosphate oxidase gene presenting with neonatal seizures unresponsive to pyridoxine and anticonvulsant treatment but responsive to pyridoxal phosphate is described. (nih.gov)
  • Pyridoxal 5′-phosphate oxidase and pyridoxal phosphate phosphatase immunoreactivities were changed in neurons up to 2 days after ischemia, while 4 days after ischemia their immunoreactivities were expressed in astrocytes. (elsevier.com)
  • Pyridoxal 5′-phosphate oxidase immunoreactivity and its protein level were highest 12 h after ischemia, while those in pyridoxal phosphate phosphatase were highest 2 days after ischemia. (elsevier.com)
Known as pyridoxal 5-phospha1
  • Pyridoxal-phosphate is also known as pyridoxal 5-phosphate or (as we referred to it above) P5P. (anh-usa.org)
Levels of pyridoxal-phosphate1
  • Dr. Larsson l inked the effect to bloodstream levels of pyridoxal-phosphate (PLP), the main active coenzyme form of vitamin B6 . (anh-usa.org)
Protein4
  • The pyridoxal ring is buried in a nonpolar site containing three aromatic rings while the 5'-phosphate group is highly solvated and makes only three direct contacts to the protein. (ox.ac.uk)
  • A pyridoxal-phosphate protein. (genome.jp)
  • The encoded protein is allosterically activated by adenosyl-methionine and uses pyridoxal phosphate as a cofactor. (fishersci.com)
  • Roscovitine targets, protein kinases and pyridoxal kinase. (harvard.edu)
Phosphatase1
  • Encodes RHD4 (ROOT HAIR DEFECTIVE4), a phosphatidylinositol-4-phosphate phosphatase required for root hair development. (or.jp)
Biotin1
Cofactor pyridoxal4
  • The detailed environment of the essential cofactor pyridoxal 5'-phosphate in glycogen phosphorylase b, resulting from crystallographic refinement at 1.9-A resolution, is described. (ox.ac.uk)
  • mtClpX activates ALAS by accelerating incorporation of its cofactor, pyridoxal 5'-phosphate (PLP). (elifesciences.org)
  • Chick brain GAD proved to be unstable so attempts were made to develop an efficient affinity chromatography procedure (using the cofactor pyridoxal-5-phosphate (PLP) as the ligand) which would enable purification to homogeneity with a minimum number of steps. (bl.uk)
  • The complex formed between the C116H mutant and methionine demonstrated that a loop structure (Ala51-Asn64) in the adjacent subunit of the catalytic dimer cannot approach the cofactor pyridoxal 5′-phosphate (PLP) because His116 disrupts the interaction of Asp241 with Lys240, and the liberated side chain of Lys240 causes steric hindrance with this loop. (elsevier.com)
Combination of pyridoxine2
  • Pyridoxamine is a chemical combination of pyridoxine and pyridoxal. (healthifybody.com)
  • A combination of pyridoxine hydrochloride and pyridoxal-5-phosphate (P5P). (nutricology.com)
Pyridoxamine phosphate1
  • During transamination of amino acids, pyridoxal phosphate is transiently converted into pyridoxamine phosphate ( PYRIDOXAMINE ). (bvsalud.org)
Neonatal2
  • Pyridoxal phosphate-dependent neonatal epileptic encephalopathy. (medlineplus.gov)
  • Pyridoxal phosphate should be considered in neonatal epileptic encephalopathy unresponsive to pyridoxine. (nih.gov)
Inositol1
Seizures1
  • Even though seizures can be controlled with pyridoxal 5'-phosphate, neurological problems such as developmental delay and learning disorders may still occur. (medlineplus.gov)
Phosphorylation2
  • Catalyzes the phosphorylation of pyridoxal to PLP in vivo, but shows very low activity compared to PdxK. (uniprot.org)
  • An enzyme that catalyzes reversibly the phosphorylation of pyridoxal in the presence of ATP with the formation of pyridoxal 5-phosphate and ADP. (harvard.edu)
Proteins2
  • Pyridoxal 5'-phosphate is the metabolically active form of vitamin B6 that has been shown to protect living lipids and proteins against glycation reactions. (royaltyhealth.com)
  • The same reaction can also be catalysed by some pyridoxal-phosphate proteins (cf. (genome.jp)
Dependent enzymes2
  • Pyridoxal-5'-phosphate dependent enzymes mutation. (receptors.org)
  • Aminotransferases share certain mechanistic features with other pyridoxal- phosphate dependent enzymes, such as the covalent binding of the pyridoxal- phosphate group to a lysine residue. (nih.gov)
Gene2
  • This is a nuclear gene encoding a mitochondrial enzyme that catalyzes the conversion of 5-phosphonooxy-L-lysine to ammonia, inorganic phosphate, and 2-aminoadipate semialdehyde. (nih.gov)
  • From NCBI Gene: This gene encodes a member of the class-V pyridoxal-phosphate-dependent aminotransferase family. (nih.gov)
Acid7
  • Background We quantified pyridoxal 5′-phosphate (PLP), pyridoxal (PL), and 4-pyridoxic acid (PA) in paired serum and cerebrospinal fluid (CSF) samples from children and investigated the effect of age on the concentrations and CSF-to-serum ratios of these vitamers. (elsevier.com)
  • Treatment with pyridoxal 5′-phosphate into brains (4 μg/5 μl, i.c.v.) at 30 min before transient ischemia protected about 80% of CA1 pyramidal cells 4 days after ischemia and induced elevation of glutamic acid decarboxylase 67 immunoreactivity in the CA1 region. (elsevier.com)
  • The chemical reactions and pathways involving the phosphate group, the anion or salt of any phosphoric acid. (mcw.edu)
  • In this study the noncompetitive inhibition of the AP5A-induced vasoconstriction with pyridoxal-phosphate-6-azophenyl-2′,4′-disulphonic acid was found to be significantly stronger in MrA than in SEA. (aspetjournals.org)
  • The vasoconstriction by the P2X purinoceptor agonist α,β-methylene ATP was inhibited by with pyridoxal-phosphate-6-azophenyl-2′,4′-disulfonic acid and suramin similarly to that induced by AP5A. (aspetjournals.org)
  • Jarrow Formulas® Methyl-B12, Methylfolate Plus Pyridoxal-5-Phosphate (P5P) Tablet combines the active forms of these vitamins to support DNA and neurotransmitter synthesis and amino acid metabolism. (herbspro.com)
  • 4. Enhancement of 5-Fluorouracil Cytotoxicity by Pyridoxal 5'-Phosphate and Folinic Acid in Tandem. (nih.gov)
Transaminases1
  • Discuss the role of pyridoxal phosphate (Vitamin B6) in laboratory testing for transaminases. (aacc.org)
Kinase9
  • Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). (uniprot.org)
  • Pyridoxal Kinase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (harvard.edu)
  • This graph shows the total number of publications written about "Pyridoxal Kinase" by people in Harvard Catalyst Profiles by year, and whether "Pyridoxal Kinase" was a major or minor topic of these publication. (harvard.edu)
  • Below are the most recent publications written about "Pyridoxal Kinase" by people in Profiles. (harvard.edu)
  • Pyridoxal 5'-phosphate is a slow tight binding inhibitor of E. coli pyridoxal kinase. (harvard.edu)
  • Crystal structures of human pyridoxal kinase in complex with the neurotoxins, ginkgotoxin and theophylline: insights into pyridoxal kinase inhibition. (harvard.edu)
  • Kinetic and structural studies of the role of the active site residue Asp235 of human pyridoxal kinase. (harvard.edu)
  • Crystal Structure of human pyridoxal kinase: structural basis of M(+) and M(2+) activation. (harvard.edu)
  • Crystal structure of pyridoxal kinase in complex with roscovitine and derivatives. (harvard.edu)
Physiological2
  • These results suggest that the intestine and/or liver play a major role in completely converting physiological amounts of pyridoxamine to circulating pyridoxal, which is then taken up and phosphorylated by other organs. (go.jp)
  • Physiological functions: Pyridoxal phosphate acts as a wheal. (cadasb.org)
Zinc1
  • Changes in serum copper and zinc during treatment with anticancer drugs interfering with pyridoxal phosphate. (semanticscholar.org)
PNPO gene: MedlinePlus Genetics
PNPO gene: MedlinePlus Genetics (medlineplus.gov)
Vitamin B Test: MedlinePlus Medical Test
Vitamin B Test: MedlinePlus Medical Test (medlineplus.gov)
Humira and Arthralgia - Suspected Cause - Reports of Side Effects
Humira and Arthralgia - Suspected Cause - Reports of Side Effects (druglib.com)
Pyridoxal 5'-phosphate-dependent epilepsy: MedlinePlus Genetics
Pyridoxal 5'-phosphate-dependent epilepsy: MedlinePlus Genetics (medlineplus.gov)
Diabetic Neuropathy Clinical Presentation: History, Physical Examination, Classification of Diabetic Neuropathy
Diabetic Neuropathy Clinical Presentation: History, Physical Examination, Classification of Diabetic Neuropathy (medscape.com)
Metformin Link to Vitamin B12 Deficiency, Neuropathy in Diabetes
Metformin Link to Vitamin B12 Deficiency, Neuropathy in Diabetes (medscape.com)
Small Fiber Neuropathy Rising in the US, But Why Is a Mystery
Small Fiber Neuropathy Rising in the US, But Why Is a Mystery (medscape.com)
Spinal Cord Stimulation May Help Diabetic Neuropathy
Spinal Cord Stimulation May Help Diabetic Neuropathy (medscape.com)
B vitamin blood concentrations and one-carbon metabolism polymorphisms in a sample of Italian women and men attending a unit of...
B vitamin blood concentrations and one-carbon metabolism polymorphisms in a sample of Italian women and men attending a unit of... (link.springer.com)
Jarrow Formulas, Inc. Methyl B-12 & Methyl Folate + P-5-P - Cherry 60 Chwbls - Swanson®
Jarrow Formulas, Inc. Methyl B-12 & Methyl Folate + P-5-P - Cherry 60 Chwbls - Swanson® (swansonvitamins.com)
Vitamina B6: MedlinePlus suplementos
Vitamina B6: MedlinePlus suplementos (medlineplus.gov)
RCSB PDB - 1ARI: Aspartate aminotransferase, W140H mutant, maleate complex
RCSB PDB - 1ARI: Aspartate aminotransferase, W140H mutant, maleate complex (rcsb.org)
Nature's Way Vitamin B6 50 mg - Nutrivene
Nature's Way Vitamin B6 50 mg - Nutrivene (nutrivene.com)
RCSB PDB - 1AKA: STRUCTURAL BASIS FOR THE CATALYTIC ACTIVITY OF ASPARTATE AMINOTRANSFERASE K258H LACKING ITS PYRIDOXAL-5'...
RCSB PDB - 1AKA: STRUCTURAL BASIS FOR THE CATALYTIC ACTIVITY OF ASPARTATE AMINOTRANSFERASE K258H LACKING ITS PYRIDOXAL-5'... (rcsb.org)
Vitamins Tablets Manufacturers, Suppliers, Dealers & Prices
Vitamins Tablets Manufacturers, Suppliers, Dealers & Prices (tradeindia.com)
KEGG ORTHOLOGY: K15631
KEGG ORTHOLOGY: K15631 (genome.jp)
FDA Approves Tapentadol ER for Diabetic Neuropathy
FDA Approves Tapentadol ER for Diabetic Neuropathy (medscape.com)
Reversal of Neuropathic Pain in Diabetes
Reversal of Neuropathic Pain in Diabetes (medscape.com)
Corneal Microscopy Detects Diabetic Autonomic Neuropathy
Corneal Microscopy Detects Diabetic Autonomic Neuropathy (medscape.com)
Surgery May Help in Diabetic Neuropathy With Squeezed Leg Nerves
Surgery May Help in Diabetic Neuropathy With Squeezed Leg Nerves (medscape.com)
Evidence Scant on Nutraceuticals for Neuropathy in Diabetes
Evidence Scant on Nutraceuticals for Neuropathy in Diabetes (medscape.com)