Pyridoxal Phosphate
This is the active form of VITAMIN B 6 serving as a coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, aminolevulinic acid. During transamination of amino acids, pyridoxal phosphate is transiently converted into pyridoxamine phosphate (PYRIDOXAMINE).
Pyridoxal
Pyridoxal Kinase
Pyridoxine
The 4-methanol form of VITAMIN B 6 which is converted to PYRIDOXAL PHOSPHATE which is a coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, aminolevulinic acid. Although pyridoxine and Vitamin B 6 are still frequently used as synonyms, especially by medical researchers, this practice is erroneous and sometimes misleading (EE Snell; Ann NY Acad Sci, vol 585 pg 1, 1990).
Pyridoxamine
Vitamin B 6 Deficiency
A nutritional condition produced by a deficiency of VITAMIN B 6 in the diet, characterized by dermatitis, glossitis, cheilosis, and stomatitis. Marked deficiency causes irritability, weakness, depression, dizziness, peripheral neuropathy, and seizures. In infants and children typical manifestations are diarrhea, anemia, and seizures. Deficiency can be caused by certain medications, such as isoniazid.
Transaminases
Tryptophan Synthase
An enzyme that catalyzes the conversion of L-serine and 1-(indol-3-yl)glycerol 3-phosphate to L-tryptophan and glyceraldehyde 3-phosphate. It is a pyridoxal phosphate protein that also catalyzes the conversion of serine and indole into tryptophan and water and of indoleglycerol phosphate into indole and glyceraldehyde phosphate. (From Enzyme Nomenclature, 1992) EC 4.2.1.20.
Aspartate Aminotransferases
Apoenzymes
Pyridoxaminephosphate Oxidase
Vitamin B 6
VITAMIN B 6 refers to several PICOLINES (especially PYRIDOXINE; PYRIDOXAL; & PYRIDOXAMINE) that are efficiently converted by the body to PYRIDOXAL PHOSPHATE which is a coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, and aminolevulinic acid. During transamination of amino acids, pyridoxal phosphate is transiently converted into PYRIDOXAMINE phosphate. Although pyridoxine and Vitamin B 6 are still frequently used as synonyms, especially by medical researchers, this practice is erroneous and sometimes misleading (EE Snell; Ann NY Acad Sci, vol 585 pg 1, 1990). Most of vitamin B6 is eventually degraded to PYRIDOXIC ACID and excreted in the urine.
Lyases
Glycine Hydroxymethyltransferase
Schiff Bases
Phosphorylases
D-Alanine Transaminase
Pyridoxic Acid
L-Serine Dehydratase
Tyrosine Phenol-Lyase
Spectrophotometry
Carboxy-Lyases
Ornithine-Oxo-Acid Transaminase
Binding Sites
Escherichia coli
A species of gram-negative, facultatively anaerobic, rod-shaped bacteria (GRAM-NEGATIVE FACULTATIVELY ANAEROBIC RODS) commonly found in the lower part of the intestine of warm-blooded animals. It is usually nonpathogenic, but some strains are known to produce DIARRHEA and pyogenic infections. Pathogenic strains (virotypes) are classified by their specific pathogenic mechanisms such as toxins (ENTEROTOXIGENIC ESCHERICHIA COLI), etc.
Calcium Phosphates
Spectrophotometry, Ultraviolet
Tyrosine Decarboxylase
Hydrogen-Ion Concentration
Glucose-6-Phosphate
Glyceraldehyde-3-Phosphate Dehydrogenases
Hemoglobin C Disease
Tryptophanase
An enzyme that catalyzes the conversion of L-tryptophan and water to indole, pyruvate, and ammonia. It is a pyridoxal-phosphate protein, requiring K+. It also catalyzes 2,3-elimination and beta-replacement reactions of some indole-substituted tryptophan analogs of L-cysteine, L-serine, and other 3-substituted amino acids. (From Enzyme Nomenclature, 1992) EC 4.1.99.1.
Phosphorylase b
Pimelic Acids
Cysteine Synthase
Cystathionine beta-Synthase
Substrate Specificity
5-Aminolevulinate Synthetase
An enzyme of the transferase class that catalyzes condensation of the succinyl group from succinyl coenzyme A with glycine to form delta-aminolevulinate. It is a pyridoxyal phosphate protein and the reaction occurs in mitochondria as the first step of the heme biosynthetic pathway. The enzyme is a key regulatory enzyme in heme biosynthesis. In liver feedback is inhibited by heme. EC 2.3.1.37.
Plants, Edible
An organism of the vegetable kingdom suitable by nature for use as a food, especially by human beings. Not all parts of any given plant are edible but all parts of edible plants have been known to figure as raw or cooked food: leaves, roots, tubers, stems, seeds, buds, fruits, and flowers. The most commonly edible parts of plants are FRUIT, usually sweet, fleshy, and succulent. Most edible plants are commonly cultivated for their nutritional value and are referred to as VEGETABLES.
Amino Acid Sequence
Amino Acids
Molecular Sequence Data
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Coenzymes
Anemia, Sideroblastic
Erythrocytes
Dimercaprol
4-Aminobutyrate Transaminase
Dialysis
Aminooxyacetic Acid
Catalysis
Protein Binding
Tyrosine Transaminase
An enzyme that catalyzes the conversion of L-TYROSINE and 2-oxoglutarate to 4-hydroxyphenylpyruvate and L-GLUTAMATE. It is a pyridoxal-phosphate protein. L-PHENYLALANINE is hydroxylated to L-tyrosine. The mitochondrial enzyme may be identical with ASPARTATE AMINOTRANSFERASES (EC 2.6.1.1.). Deficiency of this enzyme may cause type II Tyrosinemia (see TYROSINEMIAS). EC 2.6.1.5.
Chemistry
Chemical Phenomena
PQQ Cofactor
Glyceraldehyde 3-Phosphate
Threonine Dehydratase
A pyridoxal-phosphate protein that catalyzes the deamination of THREONINE to 2-ketobutyrate and AMMONIA. The role of this enzyme can be biosynthetic or biodegradative. In the former role it supplies 2-ketobutyrate required for ISOLEUCINE biosynthesis, while in the latter it is only involved in the breakdown of threonine to supply energy. This enzyme was formerly listed as EC 4.2.1.16.
Inositol Phosphates
Liver
Magnetic Resonance Spectroscopy
Transferases
Transferases are enzymes transferring a group, for example, the methyl group or a glycosyl group, from one compound (generally regarded as donor) to another compound (generally regarded as acceptor). The classification is based on the scheme "donor:acceptor group transferase". (Enzyme Nomenclature, 1992) EC 2.
Protein Conformation
The characteristic 3-dimensional shape of a protein, including the secondary, supersecondary (motifs), tertiary (domains) and quaternary structure of the peptide chain. PROTEIN STRUCTURE, QUATERNARY describes the conformation assumed by multimeric proteins (aggregates of more than one polypeptide chain).
Alanine Transaminase
Adenosine Triphosphate
Serine
Chromatography, High Pressure Liquid
Swine
Any of various animals that constitute the family Suidae and comprise stout-bodied, short-legged omnivorous mammals with thick skin, usually covered with coarse bristles, a rather long mobile snout, and small tail. Included are the genera Babyrousa, Phacochoerus (wart hogs), and Sus, the latter containing the domestic pig (see SUS SCROFA).
Spectrum Analysis
Pentose Phosphate Pathway
An oxidative decarboxylation process that converts GLUCOSE-6-PHOSPHATE to D-ribose-5-phosphate via 6-phosphogluconate. The pentose product is used in the biosynthesis of NUCLEIC ACIDS. The generated energy is stored in the form of NADPH. This pathway is prominent in tissues which are active in the synthesis of FATTY ACIDS and STEROIDS.
Adenosine Monophosphate
Ornithine Decarboxylase
Glycine
Models, Molecular
Electrophoresis, Polyacrylamide Gel
Cyanides
Phosphate Transport Proteins
Circular Dichroism
Stereoisomerism
Macromolecular Substances
Purinergic P2 Receptor Antagonists
Glucose-6-Phosphate Isomerase
An aldose-ketose isomerase that catalyzes the reversible interconversion of glucose 6-phosphate and fructose 6-phosphate. In prokaryotic and eukaryotic organisms it plays an essential role in glycolytic and gluconeogenic pathways. In mammalian systems the enzyme is found in the cytoplasm and as a secreted protein. This secreted form of glucose-6-phosphate isomerase has been referred to as autocrine motility factor or neuroleukin, and acts as a cytokine which binds to the AUTOCRINE MOTILITY FACTOR RECEPTOR. Deficiency of the enzyme in humans is an autosomal recessive trait, which results in CONGENITAL NONSPHEROCYTIC HEMOLYTIC ANEMIA.
Mutation
Tryptophan
An essential amino acid that is necessary for normal growth in infants and for NITROGEN balance in adults. It is a precursor of INDOLE ALKALOIDS in plants. It is a precursor of SEROTONIN (hence its use as an antidepressant and sleep aid). It can be a precursor to NIACIN, albeit inefficiently, in mammals.
Base Sequence
Alanine
Sulfhydryl Reagents
Chromatography
Techniques used to separate mixtures of substances based on differences in the relative affinities of the substances for mobile and stationary phases. A mobile phase (fluid or gas) passes through a column containing a stationary phase of porous solid or liquid coated on a solid support. Usage is both analytical for small amounts and preparative for bulk amounts.
Structure-Activity Relationship
Update on interconversions of vitamin B-6 with its coenzyme. (1/1448)
Biosynthesis of pyridoxal 5'-phosphate (PLP) depends upon the relatively specific action of two consecutive enzymes, viz. pyridoxal (pyridoxine, pyridoxamine) kinase and pyridoxine (pyridoxamine) phosphate oxidase. Less specific phosphatases catalyze hydrolyses of the 5'-phosphates of the vitamers pyridoxal, pyridoxamine, and pyridoxine. From the recognition a generation ago of these processes by which the three forms of vitamin B-6 and their 5'-phosphates are interconverted, more recent studies have provided a fairly sophisticated understanding of the molecular characteristics of the enzymes involved. The evolutionary retention of homologous portions of pyridoxal kinase in humans as well as bacteria and the most recent finding of a highly conserved region of the pyridoxine (pyridoxamine) phosphate oxidase, also from both prokaryotic and eukaryotic organisms, emphasize the importance of these catalysts in the formation of a coenzyme that is essential for most organisms. Both kinase and oxidase involved in B-6 metabolism are potential targets for pharmacologic agents. (+info)Reaction specificity of native and nicked 3,4-dihydroxyphenylalanine decarboxylase. (2/1448)
3,4-Dihydroxyphenylalanine (Dopa) decarboxylase is a stereospecific pyridoxal 5'-phosphate (PLP)-dependent alpha-decarboxylase that converts L-aromatic amino acids into their corresponding amines. We now report that reaction of the enzyme with D-5-hydroxytryptophan or D-Dopa results in a time-dependent inactivation and conversion of the PLP coenzyme to pyridoxamine 5'-phosphate and PLP-D-amino acid Pictet-Spengler adducts, which have been identified by high performance liquid chromatography. We also show that the reaction specificity of Dopa decarboxylase toward aromatic amines depends on the experimental conditions. Whereas oxidative deamination occurs under aerobic conditions (Bertoldi, M., Moore, P. S., Maras, B., Dominici, P., and Borri Voltattorni, C. (1996) J. Biol. Chem. 271, 23954-23959; Bertoldi, M., Dominici, P., Moore, P. S., Maras, B., and Borri Voltattorni, C. (1998) Biochemistry 37, 6552-6561), half-transamination and Pictet-Spengler reactions take place under anaerobic conditions. Moreover, we examined the reaction specificity of nicked Dopa decarboxylase, obtained by selective tryptic cleavage of the native enzyme between Lys334 and His335. Although this enzymatic species does not exhibit either decarboxylase or oxidative deamination activities, it retains a large percentage of the native transaminase activity toward D-aromatic amino acids and displays a slow transaminase activity toward aromatic amines. These transamination reactions occur concomitantly with the formation of cyclic coenzyme-substrate adducts. Together with additional data, we thus suggest that native Dopa decarboxylase can exist as an equilibrium among "open," "half-open," and "closed" forms. (+info)Carbon 13 NMR study of nonenzymatic reactions of pyridoxal 5'-phosphate with selected amino acids and of related reactions. (3/1448)
Carbon 13 nuclear magnetic resonance spectroscopy has been used to monitor the nonenzymatic reactions of pyridoxal 5'-phosphate with glycine, alanine, valine, serine, and with several other model compounds. Isotopically enriched amino acids were employed so that low concentrations could be utilized while still allowing relatively rapid acquisition of spectral data. The results for alanine and serine are particularly noteworthy in that alanine is deaminated to pyruvate and pyruvate is aminated to alanine, but contrary to the enzymatic reactions of various serine dehydratases wherein serine is converted to pyruvate, the nonenzymatic reaction utilizing serine results in hydroxypruvate rather than pyruvate formation. In the reverse reaction, hydroxypyruvate is aminated to serine but very inefficiently relative to the amination of pyruvate to alanine. The experimental results have been formulated into a proposed reaction mechanism for deamination of amino acids by pyridoxal-P. (+info)A prospective study on folate, B12, and pyridoxal 5'-phosphate (B6) and breast cancer. (4/1448)
To investigate the incidence of breast cancer and prediagnostic serum levels of folate, B12, and pyridoxal 5'-phosphate (B6), we conducted a nested case-control study using resources from the Washington County (Maryland) serum bank. In 1974, 12,450 serum specimens were donated, and in 1989, 14,625 plasma specimens were donated by female residents of Washington County. One hundred ninety-five incident breast cancer cases and 195 controls were matched by age, race, menopausal status at donation, and cohort participation as well as by date of blood donation. In both cohorts and all menopausal subgroups, median B12 concentrations were lower among cases than controls. Differences reached statistical significance only among women who were postmenopausal at donation (1974 cohort, 413 versus 482 pg/ml, P = 0.03; 1989 cohort, 406 versus 452 pg/ml, P = 0.02). Among women postmenopausal at blood donation, observed associations of B12 suggested a threshold effect with increased risk of breast cancer in the lowest one-fifth compared to the higher four-fifths of the control distribution [lowest versus highest fifth: 1974 cohort, matched odds ratio = 4.00 (95% confidence interval = 1.05-15.20); 1989 cohort, matched odds ratio = 2.25 (95% confidence interval = 0.86-5.91)]. We found no evidence for an association between folate, B6, and homocysteine and breast cancer. Findings suggested a threshold effect for serum B12 with an increased risk of breast cancer among postmenopausal women in the lowest one-fifth compared to the higher four-fifths of the control distribution. These results should stimulate further investigations of potentially modifiable risk factors, such as these B-vitamins, for prevention of breast cancer. (+info)Serine transhydroxymethylase from rabbit liver. Sequence of anonapeptide at the pyridoxal-5'-phosphate-binding site. (5/1448)
The amino acid sequence of the coenzyme-binding site of serine transhydroxymethylase from rabbit liver has been determined. After reduction with NaBH4 and aminoethylation, a first sample of enzyme was digested with thermolysin and a single phosphopyridoxyl peptide was isolated. A second sample of similarly treated enzyme was digested with chymotrypsin and three phosphopyridoxyl peptides clearly originating from a unique coenzyme-binding site were isolated. Sequence analysis of these peptides indicate the following structure: Val-Val-Thr-Thr-His(Pxy)-Thr-Leu. Sequence homologies of the active site of various pyridoxalphosphate enzymes are discussed in terms of a possible catalytic role and of evolution of this class of proteins. (+info)Effects of vasopressin on the sympathetic contraction of rabbit ear artery during cooling. (6/1448)
In order to analyse the effects of arginine-vasopressin on the vascular contraction to sympathetic nerve stimulation during cooling, the isometric response of isolated, 2-mm segments of the rabbit central ear (cutaneous) artery to electrical field stimulation (1-8 Hz) was recorded at 37 and 30 degrees C. Electrical stimulation (37 degrees C) produced frequency-dependent arterial contraction, which was reduced at 30 degrees C and potentiated by vasopressin (10 pM, 100 pM and 1 nM). This potentiation was greater at 30 than at 37 degrees C and was abolished at both temperatures by the antagonist of vasopressin V1 receptors d(CH2)5 Tyr(Me)AVP (100 nM). Desmopressin (1 microM) did not affect the response to electrical stimulation. At 37 degrees C, the vasopressin-induced potentiation was abolished by the purinoceptor antagonist PPADS (30 microM), increased by phentolamine (1 microM) or prazosin (1 microM) and not modified by yohimbine (1 microM), whilst at 30 degrees C, the potentiation was reduced by phentolamine, yohimbine or PPADS, and was not modified by prazosin. The Ca2+-channel blockers, verapamil (10 microM) and NiCl2 (1 mM), abolished the potentiating effects of vasopressin at 37 degrees C whilst verapamil reduced and NiCl2 abolished this potentiation at 30 degrees C. The inhibitor of nitric oxide synthesis, L-NOARG (100 microM), or endothelium removal did not modify the potentiation by vasopressin at 37 and 30 degrees C. Vasopressin also increased the arterial contraction to the alpha2-adrenoceptor agonist BHT-920 (10 microM) and to ATP (2 mM) at 30 and 37 degrees C, but it did not modify the contraction to noradrenaline (1 microM) at either temperature. These results suggest that in cutaneous (ear) arteries, vasopressin potentiaties sympathetic vasoconstriction to a greater extent at 30 than at 37 degrees C by activating vasopressin V1 receptors and Ca2+ channels at both temperatures. At 37 degrees C, the potentiation appears related to activation of the purinoceptor component and, at 30 degrees C, to activation of both purinoceptor and alpha2-adrenoceptor components of the sympathetic response. (+info)Rat liver serine dehydratase. Bacterial expression and two folding domains as revealed by limited proteolysis. (7/1448)
A pCW vector harboring rat liver serine dehydratase cDNA was expressed in Escherichia coli. The expressed level was about 5-fold higher in E. coli BL21 than in JM109 cell extract; the former lacked two kinds of proteases. Immunoblot analysis revealed the occurrence of a derivative other than serine dehydratase in the JM109 cell extract. The recombinant enzyme was purified to homogeneity. Staphylococcus aureus V8 protease and trypsin cleaved the enzyme at Glu-206 and Lys-220, respectively, with a concomitant loss of enzyme activity. Spectrophotometrically, the nicked enzyme showed a approximately 50% reduced capacity for binding of the coenzyme pyridoxal phosphate and no spectral change of circular dichroism in the region at 300-480 nm, whereas circular dichroism spectra of both enzymes in the far-UV region were similar, suggesting that proteolysis impairs the coenzyme binding without an accompanying gross change of the secondary structure. Whereas the nicked enzyme behaved like the intact enzyme on Sephadex G-75 column chromatography, it was dissociated into two fragments on the column containing 6 M urea. Upon the removal of urea, both fragments spontaneously refolded. These results suggest that serine dehydratase consists of two folding domains connected by a region that is very susceptible to proteases. (+info)Chemical modification of NADP-isocitrate dehydrogenase from Cephalosporium acremonium evidence of essential histidine and lysine groups at the active site. (8/1448)
NADP-isocitrate dehydrogenase from Cephalosporium acremonium CW-19 has been inactivated by diethyl pyrocarbonate following a first-order process giving a second-order rate constant of 3.0 m-1. s-1 at pH 6.5 and 25 degrees C. The pH-inactivation rate data indicated the participation of a group with a pK value of 6.9. Quantifying the increase in absorbance at 240 nm showed that six histidine residues per subunit were modified during total inactivation, only one of which was essential for catalysis, and substrate protection analysis would seem to indicate its location at the substrate binding site. The enzyme was not inactivated by 5, 5'-dithiobis(2-nitrobenzoate), N-ethylmaleimide or iodoacetate, which would point to the absence of an essential reactive cysteine residue at the active site. Pyridoxal 5'-phosphate reversibly inactivated the enzyme at pH 7.7 and 5 degrees C, with enzyme activity declining to an equilibrium value within 15 min. The remaining activity depended on the modifier concentration up to about 2 mm. The kinetic analysis of inactivation and reactivation rate data is consistent with a reversible two-step inactivation mechanism with formation of a noncovalent enzyme-pyridoxal 5'-phosphate complex prior to Schiff base formation with a probable lysyl residue of the enzyme. The analysis of substrate protection shows the essential residue(s) to be at the active site of the enzyme and probably to be involved in catalysis. (+info)
Pyridoxal Phosphate Ying An - Drugs.com
Studies on the changes in protein fluorescence and enzymic activity of aspartate aminotransferase on binding of pyridoxal 5′...
TIGR01437
Pyridoxal phosphate (P5P)
HOGENOMDNA: ASFUM1 6.PE19
Domain combinations for gap ,81296, gap superfamilies in Saccharomyces cerevisiae AWRI796
GADL1 (glutamate decarboxylase like 1) - Chinchilla Research Resource Database
Noncoded amino acid replacement probes of the aspartate aminotransferase mechanism
Pyridoxal 5-phosphate | 41468-25-1
Pyridoxal phosphate-dependent transferase, subdomain 2 (IPR015422) | InterPro | EMBL-EBI
Diferència entre revisions de la pàgina «Cofactor enzimàtic» - Viquipèdia, lenciclopèdia lliure
Sequence Similarity
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Sequence Similarity
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L-methylfolate+Methylcobalamin+Pyridoxal 5-phosphate - L-methylfolate+Methylcobalamin+Pyridoxal 5-phosphate Exporter,...
Use of Chlorite to Improve HPLC Detection of Pyridoxal 5-phosphate by Karen L. Ericson, J. D. Mahuren et al.
Pyridoxal-5-Phosphate (P-5-P) Reviews on 20bestsellers.co.uk - Product Reviews on 20bestsellers.co.uk
Pyridoxal- 5-phosphate monohydrate | Abcam
Publications | CBCB
SAUSA300 RS12860 - AureoWiki
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PEGylated d-serine dehydratase as a d-serine reducing agent<...
PubMed Kidney Transplant | Transplant Professional Portal
Wu, F<...
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Kemija vitamina B6 i sinteza novih analoga vitamina B6 | Repozitorij Odjela za kemiju, Osijek
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Criteria of supply of vitamins B1, B2, and B6 in children with insulin-dependent diabetes mellitus
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pdxS - Pyridoxal 5-phosphate synthase subunit PdxS - Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) - pdxS gene &...
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Pyridoxal - DrugBank
TIGR04434
Plasma pyridoxal 5-phosphate [active co-enzyme form of vitamin B-6] in the US population: The National Health and Nutrition...
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Pyridoxal phosphate
... (PLP, pyridoxal 5'-phosphate, P5P), the active form of vitamin B6, is a coenzyme in a variety of enzymatic ... Pyridoxal phosphate is a cofactor of ornithine carboxylase. Transamination. Pyridoxal phosphate takes part in decomposition and ... Pyridoxal phosphate has numerous roles in human body. A few examples below: Metabolism and biosynthesis of serotonin. Pyridoxal ... The condensation product of 3-hydroxy-1-aminoacetone phosphate and deoxyxylulose 5-phosphate is pyridoxine 5'-phosphate. The ...
Magnesium pyridoxal 5-phosphate glutamate
... (trade name Sedalipid) is a hypolipidemic agent. Schuitemaker GE, van der Pol GA, ... Aretz CP, Dinant GJ (2001). "A placebo-controlled, double-blind, randomised trial of magnesium-pyridoxal-5'-phosphate-glutamate ...
Pyridoxal 5'-phosphate synthase (glutamine hydrolyzing)
... pyridoxal 5′-phosphate + 4 H2O + phosphate The enzyme can also use ribulose 5-phosphate and dihydroxyacetone phosphate. Burns ... is an enzyme with systematic name D-ribose 5-phosphate,D-glyceraldehyde 3-phosphate pyridoxal 5′-phosphate-lyase. This enzyme ... pyridoxal 5′-phosphate + L-glutamate + 3 H2O + phosphate (overall reaction) (1a) L-glutamine + H2O ⇌ {\displaystyle \ ... Pyridoxal+5'-phosphate+synthase+(glutamine+hydrolyzing) at the US National Library of Medicine Medical Subject Headings (MeSH) ...
Diaminopimelate decarboxylase
"Pyridoxal phosphate". Pubchem. Retrieved 2018-03-09. Gillner DM, Becker DP, Holz RC (February 2013). "Lysine biosynthesis in ... It employs the cofactor pyridoxal phosphate, also known as PLP, which participates in numerous enzymatic transamination, ... Portal: Biology (EC 4.1.1, Pyridoxal phosphate enzymes, Enzymes of known structure). ...
Branched-chain amino acid aminotransferase
"Pyridoxal phosphate enzymology". Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics. Pyridoxal Phosphate Enzymology ... Like other transaminase enzymes (as well as many enzymes of other classes), BCATs require the cofactor pyridoxal-5'-phosphate( ... In addition, the phosphate oxygen atoms on the PLP molecule interact with the Arg99, Val269, Val270, and Thr310 residues. ...
Histidine decarboxylase
"Pyridoxal phosphate-dependent decarboxylase". InterPro. Toney MD (January 2005). "Reaction specificity in pyridoxal phosphate ... The enzyme employs a pyridoxal 5'-phosphate (PLP) cofactor, in similarity to many amino acid decarboxylases. Eukaryotes, as ... Sandmeier E, Hale TI, Christen P (May 1994). "Multiple evolutionary origin of pyridoxal-5'-phosphate-dependent amino acid ... Fernandes HS, Ramos MJ, Cerqueira NM (July 2017). "The Catalytic Mechanism of the Pyridoxal-5'-phosphate-Dependent Enzyme, ...
Cystathionine beta-lyase
The enzyme belongs to the γ-family of PLP-dependent enzymes due to its use of a pyridoxal-5'-phosphate (PLP) cofactor to cleave ... Clausen T, Huber R, Laber B, Pohlenz HD, Messerschmidt A (September 1996). "Crystal structure of the pyridoxal-5'-phosphate ... Portal: Biology (CS1: long volume value, EC 4.4.1, Pyridoxal phosphate enzymes, Enzymes of known structure). ... John RA (April 1995). "Pyridoxal phosphate-dependent enzymes". Biochimica et Biophysica Acta (BBA) - Protein Structure and ...
Arginine decarboxylase
The process consumes a proton in the decarboxylation and employs a pyridoxal-5'-phosphate (PLP) cofactor, similar to other ... John RA (April 1995). "Pyridoxal phosphate-dependent enzymes". Biochimica et Biophysica Acta (BBA) - Protein Structure and ... EC 4.1.1, Pyridoxal phosphate enzymes, Enzymes of known structure). ... Toney MD (January 2005). "Reaction specificity in pyridoxal phosphate enzymes". Archives of Biochemistry and Biophysics. 433 (1 ...
Pyridoxine 5'-phosphate synthase
... phosphate, and pyridoxine-5'-phosphate (a vitamer of pyridoxal phosphate). In the first step of this condensation reaction, the ... phosphate + phosphate + 2 H2O The two substrates of this enzyme are 1-deoxy-D-xylulose 5-phosphate (DXP) and 3-hydroxy-1- ... pdxJ plays a role in the DXP-dependent pathway of pyridoxal phosphate. The DXP-dependent pathway is found predominantly in ... Mukherjee T, Hanes J, Tews I, Ealick SE, Begley TP (November 2011). "Pyridoxal phosphate: biosynthesis and catabolism". ...
Acetylornithine transaminase
Portal: Biology v t e (EC 2.6.1, Pyridoxal phosphate enzymes, Enzymes of known structure, All stub articles, EC 2.6 stubs). ... It employs one cofactor, pyridoxal phosphate. As of late 2007, 6 structures have been solved for this class of enzymes, with ...
Beta-alanine-pyruvate transaminase
Portal: Biology v t e (EC 2.6.1, Pyridoxal phosphate enzymes, Enzymes of unknown structure, All stub articles, EC 2.6 stubs). ... It employs one cofactor, pyridoxal phosphate. HAYAISHI O, NISHIZUKA Y, TATIBANA M, TAKESHITA M, KUNO S (1961). "Enzymatic ...
Asparagine-oxo-acid transaminase
Portal: Biology v t e (EC 2.6.1, Pyridoxal phosphate enzymes, Enzymes of unknown structure, All stub articles, EC 2.6 stubs). ... It employs one cofactor, pyridoxal phosphate. MEISTER A, FRASER PE (1954). "Enzymatic formation of L-asparagine by ...
Adenosylmethionine-8-amino-7-oxononanoate transaminase
Portal: Biology v t e (EC 2.6.1, Pyridoxal phosphate enzymes, Enzymes of known structure, All stub articles, EC 2.6 stubs). ... It employs one cofactor, pyridoxal phosphate. As of late 2007, 11 structures have been solved for this class of enzymes, with ...
L-seryl-tRNASec selenium transferase
Portal: Biology v t e (EC 2.9.1, Pyridoxal phosphate enzymes, Enzymes of unknown structure, All stub articles, Transferase ... It employs one cofactor, pyridoxal phosphate. Forchhammer K, Bock A (1991). "Selenocysteine synthase from Escherichia coli. ... phosphate Thus, the two substrates of this enzyme are L-seryl-tRNASec and selenophosphate, whereas its two products are L- ... selenocysteinyl-tRNASec and phosphate. This enzyme belongs to the family of transferases, specifically those transferring ...
Threonine aldolase
It employs one cofactor, pyridoxal phosphate. As of late 2007, 5 structures have been solved for this class of enzymes, with ... Portal: Biology v t e (Protein pages needing a picture, Genes on human chromosome 17, EC 4.1.2, Pyridoxal phosphate enzymes, ...
5-aminovalerate transaminase
Portal: Biology v t e (EC 2.6.1, Pyridoxal phosphate enzymes, Enzymes of unknown structure, All stub articles, EC 2.6 stubs). ... It employs one cofactor, pyridoxal phosphate. Ichihara A, Ichihara EA, Suda M (1960). "Metabolism of L-lysine by bacterial ...
D-amino-acid transaminase
Portal: Biology v t e (EC 2.6.1, Pyridoxal phosphate enzymes, Enzymes of known structure, All stub articles, EC 2.6 stubs). ... It employs one cofactor, pyridoxal phosphate. As of late 2007, 8 structures have been solved for this class of enzymes, with ...
Aminobenzoate decarboxylase
Portal: Biology v t e (EC 4.1.1, Pyridoxal phosphate enzymes, Enzymes of unknown structure, All stub articles, EC 4.1 stubs). ... pyridoxal phosphate. McCullough WG, Piligian JT, Daniel IJ (1957). "Enzymatic decarboxylation of three aminobenzoates". J. Am. ...
Succinyldiaminopimelate transaminase
Portal: Biology v t e (EC 2.6.1, Pyridoxal phosphate enzymes, Enzymes of unknown structure, All stub articles, EC 2.6 stubs). ... It employs one cofactor, pyridoxal phosphate. Peterkofsky B, Gilvarg C (May 1961). "N-Succinyl-L-diaminopimelic-glutamic ...
3-chloro-D-alanine dehydrochlorinase
Portal: Biology v t e (EC 4.5.1, Pyridoxal phosphate enzymes, Enzymes of unknown structure, All stub articles, Lyase stubs). ... pyridoxal phosphate. Nagasawa T, Ishii T, Yamada H (1988). "Physiological comparison of D-cysteine desulfhydrase of Escherichia ...
Serine C-palmitoyltransferase
The PLP (pyridoxal 5′-phosphate)-dependent serine C-palmitoyltransferase carries out the first enzymatic step of de novo ... It employs one cofactor, pyridoxal phosphate. This enzyme belongs to the family of transferases, specifically those ... Eliot AC, Kirsch JF (2004). "Pyridoxal phosphate enzymes: mechanistic, structural, and evolutionary considerations". Annual ... Pyridoxal phosphate enzymes, Enzymes of known structure). ...
Phenylalanine decarboxylase
Portal: Biology v t e (EC 4.1.1, Pyridoxal phosphate enzymes, Enzymes of unknown structure, All stub articles, EC 4.1 stubs). ... It employs one cofactor, pyridoxal phosphate. Lovenberg W, Weissbach H, Udenfriend S (1962). "Aromatic L-amino acid ...
Arginine racemase
Portal: Biology v t e (EC 5.1.1, Pyridoxal phosphate enzymes, Enzymes of unknown structure, All stub articles, Isomerase stubs) ... It employs one cofactor, pyridoxal phosphate. Yorifuji T, Ogata K, Soda K (1969). "Crystalline arginine racemase". Biochem. ...
DTDP-4-amino-4,6-dideoxy-D-glucose transaminase
Portal: Biology v t e (EC 2.6.1, Pyridoxal phosphate enzymes, Enzymes of unknown structure, All stub articles, EC 2.6 stubs). ... It employs one cofactor, pyridoxal phosphate. Matsuhashi M, Strominger JL (1966). "Thymidine diphosphate 4-acetamido-2,6- ...
1-Aminocyclopropane-1-carboxylate synthase
source) It is a pyridoxal phosphate (PLP) dependent gamma-elimination (?). In the gamma elimination, PLP acts as a sink twice ( ... They are natural toxins that cause slow binding inhibition by interfering with the coenzyme pyridoxal phosphate. ACC synthase ... It employs one cofactor, pyridoxal phosphate. The reaction catalyzed by 1-aminocyclopropane-1-carboxylic acid synthase (ACS) is ... Portal: Biology (CS1: long volume value, EC 4.4.1, Pyridoxal phosphate enzymes, Enzymes of known structure). ...
Glutamine-scyllo-inositol transaminase
Portal: Biology v t e (EC 2.6.1, Pyridoxal phosphate enzymes, Enzymes of unknown structure, All stub articles, EC 2.6 stubs). ... It employs one cofactor, pyridoxal phosphate. Walker JB, Walker MS (1969). "Streptomycin biosynthesis. Transamination reactions ...
Glutamate-1-semialdehyde 2,1-aminomutase
Portal: Biology v t e (EC 5.4.3, Pyridoxal phosphate enzymes, Enzymes of known structure, All stub articles, Isomerase stubs). ... It employs one cofactor, pyridoxal phosphate. As of late 2007, 10 structures have been solved for this class of enzymes, with ...
Aminolevulinate transaminase
Portal: Biology v t e (EC 2.6.1, Pyridoxal phosphate enzymes, Enzymes of unknown structure, All stub articles, EC 2.6 stubs). ... It employs one cofactor, pyridoxal phosphate. Gibson KD, Matthew M, Neuberger A (1961). "Biosynthesis of porphyrins and ...
Amino-acid racemase
Portal: Biology v t e (EC 5.1.1, Pyridoxal phosphate enzymes, Enzymes of known structure, All stub articles, Isomerase stubs). ... It employs one cofactor, pyridoxal phosphate. As of late 2007, 5 structures have been solved for this class of enzymes, with ...
Glycine C-acetyltransferase
Portal: Biology v t e (EC 2.3.1, Pyridoxal phosphate enzymes, Enzymes of known structure, All stub articles, EC 2.3 stubs). ... It employs one cofactor, pyridoxal phosphate. As of late 2007, only one structure has been solved for this class of enzymes, ...
ATC code A11
A11HA05 Biotin A11HA06 Pyridoxal phosphate A11HA07 Inositol A11HA08 Tocofersolan A11HA30 Dexpanthenol A11HA31 Calcium ...
D-ornithine 4,5-aminomutase
Portal: Biology v t e (EC 5.4.3, Pyridoxal phosphate enzymes, Enzymes of unknown structure, All stub articles, Isomerase stubs) ... Somack R, Costilow RN (1973). "Purification and properties of a pyridoxal phosphate and coenzyme B 12 dependent D- -ornithine 5 ... It has 3 cofactors: pyridoxal phosphate, Cobamide coenzyme, and Dithiothreitol. ...
Glycogen phosphorylase
... has a pyridoxal phosphate (PLP, derived from Vitamin B6) at each catalytic site. Pyridoxal phosphate ... the phosphate group on the PLP readily donates a proton to an inorganic phosphate molecule, allowing the inorganic phosphate to ... Palm D, Klein HW, Schinzel R, Buehner M, Helmreich EJ (February 1990). "The role of pyridoxal 5'-phosphate in glycogen ... Glycogenolysis PDB: 3E3N Livanova NB, Chebotareva NA, Eronina TB, Kurganov BI (October 2002). "Pyridoxal 5'-phosphate as a ...
Adenosylmethionine decarboxylase
... phosphate. These proteins can be divided into two main groups which show little sequence similarity either to each other, or to ... amino acid decarboxylases AdoMetDC uses a covalently bound pyruvate residue as a cofactor rather than the more common pyridoxal ...
Melatonin
A decarboxylase with cofactor pyridoxal phosphate (PLP) removes CO2 from 5-hydroxy-L-tryptophan to produce 5-hydroxytryptamine ... This intermediate (5-HTP) is decarboxylated by pyridoxal phosphate and 5-hydroxytryptophan decarboxylase to produce serotonin. ... In these cells, synthesis starts with D-erythrose 4-phosphate and phosphoenolpyruvate, and in photosynthetic cells with carbon ...
Threo-3-hydroxy-D-aspartate ammonia-lyase
NH3 This enzyme is a pyridoxal-phosphate protein. Maeda T, Takeda Y, Murakami T, Yokota A, Wada M (December 2010). " ...
Serine racemase
Mammalian serine racemase is a pyridoxal 5'-phosphate dependent enzyme that catalyzes both the racemization of L-serine to D- ... The canonical tetraglycine loop that serves as a PLP phosphate binding pocket includes the active residues being F55, K56, G185 ...
Alpha glucan
... interrelationship between the polysaccharide and pyridoxal phosphate binding sites by affinity electrophoresis". Biochemistry. ...
Indoleacetaldoxime dehydratase
KUMAR SA, MAHADEVAN S (1963). "3-INDOLEACETALDOXIME HYDRO-LYASE: A PYRIDOXAL-5'-PHOSPHATE ACTIVATED ENZYME". Arch. Biochem. ...
Transsulfuration pathway
All four transsulfuration enzymes require vitamin B6 in its active form (pyridoxal phosphate or PLP). Three of these enzymes ( ... Clausen, T.; Huber, R.; Laber, B.; Pohlenz, H. D.; Messerschmidt, A. (1996). "Crystal Structure of the Pyridoxal-5′-phosphate ...
2,3-Diaminopropionic acid
2,3-Diaminopropionate is formed by the pyridoxal phosphate (PLP) mediated amination of serine. Frenkel-Pinter M, Haynes JW, C M ...
Cystathionine beta synthase
... a unique pyridoxal 5'-phosphate-dependent heme protein". The EMBO Journal. 20 (15): 3910-6. doi:10.1093/emboj/20.15.3910. PMC ... H2O CBS uses the cofactor pyridoxal-phosphate (PLP) and can be allosterically regulated by effectors such as the ubiquitous ... Pyridoxal phosphate enzymes, Enzymes of known structure). ...
Alanine transaminase
... require the coenzyme pyridoxal phosphate, which is converted into pyridoxamine in the first phase of the reaction, when an ...
AKR1B1
Affinity labeling of an active site lysine by pyridoxal 5'-phosphate and pyridoxal 5'-diphospho-5'-adenosine". The Journal of ... It is a reduced nicotinamide-adenine dinucleotide phosphate (NADPH)-dependent enzyme catalyzing the reduction of various ... It is a reduced nicotinamide-adenine dinucleotide phosphate (NADPH)-dependent enzyme catalyzing the reduction of various ...
Lysine 2,3-aminomutase
Pyridoxal phosphate (PLP): Responsible for binding of the amino acid during reaction. The pi-system of this molecule ... In this configuration, the radical is stabilized by the pi-system of pyridoxal phosphate. Amino Acid Conversion: In the final ... Enzyme Binding: Lysine 2,3-aminomutase binds to pyridoxal phosphate (PLP). Amino Acid Binding: The amino acid (Lysine or Beta- ... binds to pyridoxal phosphate. Radical Transfer: The 5'-deoxyadenosyl radical is transferred to the amino acid and an aziridinyl ...
UDP-4-amino-4-deoxy-L-arabinose aminotransferase
L-glutamate This protein is a pyridoxal 5'-phosphate enzyme. Breazeale SD, Ribeiro AA, Raetz CR (July 2003). "Origin of lipid A ...
Serine hydroxymethyltransferase
... (SHMT) is a pyridoxal phosphate (PLP) (Vitamin B6) dependent enzyme (EC 2.1.2.1) which plays an ... April 2015). "How pyridoxal 5'-phosphate differentially regulates human cytosolic and mitochondrial serine ... 31P nuclear magnetic resonance study of the enzyme-bound pyridoxal 5'-phosphate". The Journal of Biological Chemistry. 258 (1 ... which is induced by Pyridoxal phosphate, has recently been shown to be involved in regulation of the BRISC deubiqutylase ...
GOT1
Glutamic-oxaloacetic transaminase is a pyridoxal phosphate-dependent enzyme which exists in cytoplasmic and mitochondrial forms ...
Selenocysteine lyase
Portal: Biology v t e (EC 4.4.1, Pyridoxal phosphate enzymes, Enzymes of known structure, All stub articles, Enzyme stubs). ...
Pyridoxine 5′-phosphate oxidase
... pyridoxal 5′-phosphate + NH3 + H2O2 pyridoxine phosphate + O2 ⇌ H2O2 + pyridoxal phosphate Pyridoxine 5′-phosphate oxidase also ... Pyridoxal 5′-phosphate is an effective product inhibitor. Since pyridoxal 5′-phosphate, the active form of vitamin B6, is the ... phosphate substrate, whereas the pyridoxine 5′-phosphate oxidase in E. coli has a higher specificity pyridoxal 5′-phosphate ... Pyridoxine 5′-phosphate oxidase catalyzes the final, rate-limiting step in vitamin B6 metabolism, the biosynthesis of pyridoxal ...
D-lysine 5,6-aminomutase
Maity AN, Lin H, Chiang H, Lo H, Ke S (May 2015). "Reaction of Pyridoxal-5′-phosphate-N-oxide with Lysine 5,6-Aminomutase: ... 5,6-LAM is pyridoxal-5'-phosphate (PLP) dependent. PLP binds to its substrate with an external aldimine linkage. PLP is also ...
Pyridoxal phosphate - Wikipedia
Pyridoxal phosphate (PLP, pyridoxal 5-phosphate, P5P), the active form of vitamin B6, is a coenzyme in a variety of enzymatic ... Pyridoxal phosphate is a cofactor of ornithine carboxylase.. *Transamination. Pyridoxal phosphate takes part in decomposition ... The condensation product of 3-hydroxy-1-aminoacetone phosphate and deoxyxylulose 5-phosphate is pyridoxine 5-phosphate. The ... Pyridoxal phosphate has numerous roles in human body. A few examples below: *Metabolism and biosynthesis of serotonin. ...
Pyridoxal 5'-phosphate-dependent epilepsy: MedlinePlus Genetics
... phosphate-dependent epilepsy is a condition that involves seizures beginning soon after birth or, in some cases, before birth. ... medlineplus.gov/genetics/condition/pyridoxal-5-phosphate-dependent-epilepsy/ Pyridoxal 5-phosphate-dependent epilepsy. ... Pyridoxal 5-phosphate-dependent epilepsy is a condition that involves seizures beginning soon after birth or, in some cases, ... Mutations in the PNPO gene cause pyridoxal 5-phosphate-dependent epilepsy. The PNPO gene provides instructions for producing ...
RCSB PDB - 1AKA: STRUCTURAL BASIS FOR THE CATALYTIC ACTIVITY OF ASPARTATE AMINOTRANSFERASE K258H LACKING ITS PYRIDOXAL-5'...
STRUCTURAL BASIS FOR THE CATALYTIC ACTIVITY OF ASPARTATE AMINOTRANSFERASE K258H LACKING ITS PYRIDOXAL-5-PHOSPHATE-BINDING ... PYRIDOXAL-5-PHOSPHATE. C8 H10 N O6 P. NGVDGCNFYWLIFO-UHFFFAOYSA-N. Ligand Interaction. ... STRUCTURAL BASIS FOR THE CATALYTIC ACTIVITY OF ASPARTATE AMINOTRANSFERASE K258H LACKING ITS PYRIDOXAL-5-PHOSPHATE-BINDING ... Structural basis for the catalytic activity of aspartate aminotransferase K258H lacking the pyridoxal 5-phosphate-binding ...
Pyridoxal 5'-Phosphate Caps- My Village Green
By inhibiting these reactions and working as a coenzyme in biochemical reactions, pyridoxal 5-phosphate can support ... Pyridoxal 5ˈ-phosphate is the metabolically active form of vitamin B6. It plays a crucial role in a number of life processes ... Pyridoxal 5ˈ-phosphate is the metabolically active form of vitamin B6. It plays a crucial role in a number of life processes ... By inhibiting these reactions and working as a coenzyme in biochemical reactions, pyridoxal 5-phosphate can support healthy ...
Journal name: Biochimica et biophysica acta / Subject: spectroscopy and pyridoxal phosphate - PubAg Search Results
ENZYME - 4.3.3.6 pyridoxal 5'-phosphate synthase (glutamine hydrolyzing)
Pyridoxal 5-Phosphate API Manufacturer | Supplier | Provider
pyridoxal phosphate binding | NIH 3D Print Exchange
pyridoxal 5 phosphate | Phoenix Rising ME/CFS Forums
NHANES 2007-2008: Vitamin B6 Data Documentation, Codebook, and Frequencies
... phosphate (nmol/L). Variable Name: LBXPLP. SAS Label: Pyridoxal 5-phosphate (nmol/L). English Text: Pyridoxal 5-phosphate ( ... Pyridoxal 5-phosphate (Vitamin B6) for 2005-2006 and 2003-2004:. There was a change in pyridoxal 5-phosphate (Vitamin B6) ... In 2003-2004, plasma pyridoxal 5-phosphate (PLP) was performed using a homogeneous, enzymatic assay by A/C Diagnostics. In ...
Thorne Research Pyridoxal 5' Phosphate
Pyridoxal 5'-Phosphate 180 vegcaps - DrGina.com
Phosphate is vitamin B6 in its most bioactive and readily usable form.* Vitamin B6 pairs with magnesium for support of women ... Pyridoxal 5-Phosphate is vitamin B6 in its most bioactive and readily usable form.* Vitamin B6 pairs with magnesium for ... Pyridoxal 5-Phosphate is vitamin B6 in its most bioactive and readily usable form.* Vitamin B6 pairs with magnesium for ... Pyridoxal 5-phosphate (P5P) is also necessary for homocysteine recycling because it helps facilitate the break-down of ...
Pyridoxal 5'-phosphate monohydrate [CAS: 41468-25-1]
Pyridoxal 5'-Phosphate
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Pyridoxal 5-Phosphate 180 caps - Dr. Jill Health Store
Vitamin B6 (Pyridoxal 5′-Phosphate). 33.8mg. Other Ingredients: Calcium Laurate, Hypromellose Capsule, Microcrystalline ... Supplementing with Thornes Pyridoxal 5′-Phosphate ensures the most bioactive form of vitamin B6 is being supplemented.* This ... Pyridoxal 5′-phosphate (P5P) is also necessary for homocysteine recycling because it facilitates the break-down of homocysteine ... pyridoxine must be converted to pyridoxal 5′-phosphate (P5P).* Some individuals who have compromised liver function have ...
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P5P Vitamin B6 50mg | 250 Tablets | Pyridoxal 5 Phosphate and Coenzyme - Carlyle Nutritionals
Pyridoxal-5-Phosphate) is the active form of Vitamin B6. This essential nutrient is naturally found in nutritious fruits and ... P5P Vitamin B6 50mg , 250 Tablets , Pyridoxal 5 Phosphate and Coenzyme B6. Regular price Sale price $14.99 Unit price / per ... Commonly known as Coenzyme B6, P-5-P (Pyridoxal-5-Phosphate) is the active form of Vitamin B6. This essential nutrient is ...
Humira and Arthralgia - Suspected Cause - Reports of Side Effects
IMSEAR at SEARO: Interactions of methoxyamine with pyridoxal-5'-phosphate-Schiff's base at the active site of sheep liver...
Diabetic Neuropathy Clinical Presentation: History, Physical Examination, Classification of Diabetic Neuropathy
B vitamin blood concentrations and one-carbon metabolism polymorphisms in a sample of Italian women and men attending a unit of...
Vital Nutrients P-5-P Pyridoxal-5-Phosphate 50 mg 90 caps - Apex Pharmacy and Nutrition Center
PYRIDOXAL 5 PHOSPHATE (P5P or ACTIVATED VITAMIN B6) is required to metabolize proteins, carbohydrates, and fats and is ... Vital Nutrients P-5-P Pyridoxal-5-Phosphate 50 mg 90 caps - ... Vital Nutrients Pyridoxal 5 Phosphate ( P-5-P) 50 mcg 90 caps. ... Pyridoxal 5 Phosphate contains per capsule:. Pyridoxal 5 phosphate (activated vitamin B-6). 50mg. ... PYRIDOXAL 5 PHOSPHATE (P5P or ACTIVATED VITAMIN B6) is required to metabolize proteins, carbohydrates, and fats and is ...
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Exporter, Manufacturer, Distributor, Supplier, Trading Company, Wholesaler, Retailer & Dealer of DHA 40%w/w + Pyridoxal-5 ... Phosphate 500mcg L-Methylfolate 800mcg + Methylcobalamin 1500mcg based in Ahmedabad, India ... Get a price quote for DHA 40%w/w + Pyridoxal-5 Phosphate 500mcg L-Methylfolate 800mcg + Methylcobalamin 1500mcg ... DHA 40%w/w + Pyridoxal-5 Phosphate 500mcg L-Methylfolate 800mcg + Methylcobalamin 1500mcg ...
FolateRiboflavinCoenzymeMethylcobalaminEnzymesPyridoxamineBioactiveAminotransferaseDihydroxyacetone phosphateAmino acidsCofactorHomocysteineFormSubstrateEnzymaticEpilepticEpilepsyAssayReactionRolesLiverProteinMetabolizeRiboflavin-5-phosphaFolateDEFICIENCYOxidaseKnown as pyridoxal 5-phosphaLevels of pyridoxal-phosphateProteinPhosphataseBiotinCofactor pyridoxalCombination of pyridoxinePyridoxamine phosphateNeonatalInositolSeizuresPhosphorylationProteinsDependent enzymesGeneAcidTransaminasesKinasePhysiologicalZinc
Folate2
- Considering the interest of defining B vitamins intake with the diet for a clear definition of dietary policies together with the possible indication of supplement use, it is important to measure in a sample of healthy men and women, their plasma levels of folate and other major B vitamins, namely B12 and the active form of vitamin B6, pyridoxal 5′-phosphate (PLP), as well as that of homocysteine (tHcy). (springer.com)
- This includes methylcobalamin (active B12), methyl folate as 5-MTHF - Quatrefolic®, and pyridoxal 5' phosphate (active B6). (glutenfreesociety.org)
Riboflavin1
- ThorneVet's Basic B Complex contains the entire B-complex, including the activated forms of vitamin B2 (riboflavin 5'-phosphate), vitamin B6 (pyridoxal 5'-phosphate), folic acid (folinic acid and L-5-methyl-tetrahydrofolate), and vitamin B12 (adenosylcobalamin and methylcobalamin), as well as 80 mg choline citrate. (onlynaturalpet.com)
Coenzyme5
- Pyridoxal phosphate ( PLP , pyridoxal 5'- phosphate , P5P ), the active form of vitamin B 6 , is a coenzyme in a variety of enzymatic reactions. (wikipedia.org)
- By inhibiting these reactions and working as a coenzyme in biochemical reactions, pyridoxal 5'-phosphate can support healthy nerve, eye, cardiovascular and kidney function. (myvillagegreen.com)
- Commonly known as Coenzyme B6, P-5-P (Pyridoxal-5-Phosphate) is the active form of Vitamin B6. (carlylenutritionals.com)
- For example, the coenzyme of aminotransferase is pyridoxal phosphate. (articlesfactory.com)
- NAC also helps boost cellular levels of Glutathione, along with hard to find S-Acetyl Glutathione and synergist Pyridoxal 5'-Phosphate (P5P), the active coenzyme form of Vitamin B6. (tryunity.net)
Methylcobalamin1
- Walker MJ Jr, Morris LM, Cheng D. Improvement of cutaneous sensitivity in diabetic peripheral neuropathy with combination L-methylfolate, methylcobalamin, and pyridoxal 5'-phosphate. (medscape.com)
Enzymes4
- I reflect on my research on pyridoxal phosphate (PLP) enzymes over fifty-five years and on how I combined research with marriage and family. (jbc.org)
- Evolutionary Relationships between Pyridoxal-5'-Phosphate Dependent Enzymes. (expasy.org)
- The MocR proteins possess an N-terminal domain containing the winged Helix-Turn-Helix (wHTH) motif and a C-terminal domain whose architecture is homologous to the fold type-I pyridoxal 5'-phosphate (PLP) dependent enzymes whose archetypical protein is aspartate amino transferase (AAT). (bioinformation.net)
- A group of enzymes that transfers a phosphate group onto an alcohol group acceptor. (nih.gov)
Pyridoxamine5
- [6] In these reactions, the PLP reacts with glutamate , which transfers its alpha-amino group to PLP to make pyridoxamine phosphate (PMP). (wikipedia.org)
- This enzyme is involved in the conversion (metabolism) of vitamin B6 derived from food (in the form of pyridoxine and pyridoxamine) to the active form of vitamin B6 called pyridoxal 5'-phosphate (PLP). (medlineplus.gov)
- PNPO gene mutations result in a pyridoxine 5'-phosphate oxidase enzyme that is unable to metabolize pyridoxine and pyridoxamine, leading to a deficiency of PLP. (medlineplus.gov)
- In the process of transamination, the transferred amino group first combines with pyridoxal phosphate to form pyridoxamine phosphate, and then pyridoxamine phosphate transfers this amino group to another substance. (articlesfactory.com)
- During transamination of amino acids, pyridoxal phosphate is transiently converted into pyridoxamine phosphate ( PYRIDOXAMINE ). (bvsalud.org)
Bioactive4
- Thorne Research Pyridoxal 5' Phosphate is the bioactive form of Vitamin B6. (supplementfirst.com)
- Pyridoxal 5'-Phosphate is vitamin B6 in its most bioactive and readily usable form. (drgina.com)
- Supplementing with Thorne's Pyridoxal 5′-Phosphate ensures the most bioactive form of vitamin B6 is being supplemented. (drjillhealth.com)
- Make sure to look for vitamin B sources in their bioactive forms, like instead of plain old vitamin B6, if your manufacturer cares about you, the label will say pyridoxal-5-phosphate, the bioactive form. (pureprescriptions.com)
Aminotransferase2
- Pyridoxal phosphate also participates in the oxidative deamination of GABA, where it is a cofactor of GABA aminotransferase. (wikipedia.org)
- Mutant Aspartate Aminotransferase (K258H) without Pyridoxal-5'-Phosphate-Binding Lysine Residue. (rcsb.org)
Dihydroxyacetone phosphate2
- The enzyme can also use ribulose 5-phosphate and dihydroxyacetone phosphate. (expasy.org)
- It catalyzes the cleavage of fructose 1,6-diphosphate into glyceraldehyde phosphate and dihydroxyacetone phosphate. (articlesfactory.com)
Amino acids2
- Pyridoxal phosphate is a cofactor of aromatic L-amino acids decarboxylase . (wikipedia.org)
- Pyridoxal phosphate takes part in decomposition and synthesis of amino acids . (wikipedia.org)
Cofactor2
- Pyridoxal phosphate is a cofactor of glutamic acid decarboxylase (GAD). (wikipedia.org)
- Pyridoxal phosphate is a cofactor of ornithine carboxylase. (wikipedia.org)
Homocysteine1
- Pyridoxal 5'-phosphate (P5P) is also necessary for homocysteine recycling because it helps facilitate the break-down of homocysteine to taurine and cysteine. (drgina.com)
Form4
- Instead, individuals with this type of epilepsy are medically treated with large daily doses of pyridoxal 5'-phosphate (a form of vitamin B6). (medlineplus.gov)
- Pyridoxal 5ˈ-phosphate is the metabolically active form of vitamin B6. (myvillagegreen.com)
- 90 capsules contain 75 mg of pyridoxal-5-phosphate, the active form of vitamin B6. (omnicareexpress.com)
- Low levels of pyridoxal-5-phosphate (PLP), the active form of vitamin B6, have been measured in patients with cardiovascular disease, rheumatoid arthritis, inflammatory bowel disease, and diabetes. (mdcurrent.in)
Substrate1
- The result, replacement in a retention mode, together with the finding that tritium from the alpha-position of the substrate is recycled and appears both at C alpha and C beta of the product suggests a single base mechanism and an active site geometry of the pyridoxal phosphate- substrate complex in which H alpha and the beta-substituent are syn oriented. (unipr.it)
Enzymatic1
- In 2003-2004, plasma pyridoxal 5'-phosphate (PLP) was performed using a homogeneous, enzymatic assay by A/C Diagnostics. (cdc.gov)
Epileptic2
- Pyridoxal phosphate-dependent neonatal epileptic encephalopathy. (medlineplus.gov)
- Neonatal epileptic encephalopathy caused by mutations in the PNPO gene encoding pyridox(am)ine 5'-phosphate oxidase. (medlineplus.gov)
Epilepsy4
- Pyridoxal 5'-phosphate-dependent epilepsy is a condition that involves seizures beginning soon after birth or, in some cases, before birth. (medlineplus.gov)
- Anticonvulsant drugs, which are usually given to control seizures, are ineffective in people with pyridoxal 5'-phosphate-dependent epilepsy. (medlineplus.gov)
- Mutations in the PNPO gene cause pyridoxal 5'-phosphate-dependent epilepsy. (medlineplus.gov)
- It is not clear how the lack of PLP affects the brain and leads to the seizures that are characteristic of pyridoxal 5'-phosphate-dependent epilepsy. (medlineplus.gov)
Assay1
- Vitamin-B6 status was evaluated using the erythrocyte glutamic-pyruvic-transaminase (EGPT) assay and quantification of plasma pyridoxal-5'-phosphate. (cdc.gov)
Reaction1
- However, this enzyme does not exploit the reactive aldehyde group, but instead utilizes the phosphate group on PLP to perform its reaction. (wikipedia.org)
Roles1
- Pyridoxal phosphate has numerous roles in human body. (wikipedia.org)
Liver1
- IMSEAR at SEARO: Interactions of methoxyamine with pyridoxal-5'-phosphate-Schiff's base at the active site of sheep liver serine hydroxymethyltransferase. (who.int)
Protein1
- Pyridoxal phosphate biosynthetic protein PdxA [Interproscan]. (ntu.edu.sg)
Metabolize1
- PYRIDOXAL 5' PHOSPHATE (P5P or ACTIVATED VITAMIN B6) is required to metabolize proteins, carbohydrates, and fats and is important in the production of antibodies and red blood cells. (theapexstore.com)
Riboflavin-5-phospha3
- also known as riboflavin-5'-phosphate) and flavin adenine dinucleotide (FAD). (nih.gov)
- It is now enhanced with vitamin B2 as riboflavin-5-phosphate, Setria® glutathione, zinc, and increased amounts of activated pyridoxal-5'-phosphate. (nutricology.com)
- Provides activated B vitamins, including pyridoxal-5-phosphate, riboflavin-5-phosphate, enhanced-retention thiamin derivative benfotiamine and 800 mcg of Metafolin L-5-methyltetrahydrofolate (L-5-MTHF), the naturally occurring, universally metabolized form of folate. (vitaminsuite.com)
Folate1
- It provides the primary nutrients known to be necessary for the breakdown of homocysteine into methionine and other metabolites, including vitamin B6 as pyridoxine and pyridoxal-5'-phosphate (P5P), vitamin B12 as methylcobalamin, folate as 5-methyltetrahydrofolate (5-MTHF), trimethylglycine (TMG), and L-serine. (nutricology.com)
DEFICIENCY6
- PNPO gene mutations result in a pyridoxine 5'-phosphate oxidase enzyme that is unable to metabolize pyridoxine and pyridoxamine, leading to a deficiency of PLP. (medlineplus.gov)
- Systemic Manifestations in Pyridox(am)ine 5'-Phosphate Oxidase Deficiency. (nih.gov)
- Pyridoxal 5'-phosphate, with regard to humans, has been found to be associated with several diseases such as epilepsy, early-onset, vitamin B6-dependent, odontohypophosphatasia, pyridoxamine 5-prime-phosphate oxidase deficiency, and hypophosphatasia. (hmdb.ca)
- Phenotypic and molecular spectrum of pyridoxamine-5'-phosphate oxidase deficiency: A scoping review of 87 cases of pyridoxamine-5'-phosphate oxidase deficiency. (nih.gov)
- Strictly speaking, there is no such thing as a recommended pyridoxal 5-phosphate dosage or a pyridoxal 5-phosphate deficiency, since our bodies make this specific chemical. (healthifybody.com)
- Furthermore, the EGRAC cannot be used in people with glucose-6-phosphate dehydrogenase deficiency, which is present in about 10% of African Americans [ 8 ]. (nih.gov)
Oxidase6
- The PNPO gene provides instructions for producing an enzyme called pyridoxine 5'-phosphate oxidase. (medlineplus.gov)
- Neonatal epileptic encephalopathy caused by mutations in the PNPO gene encoding pyridox(am)ine 5'-phosphate oxidase. (medlineplus.gov)
- Pyridox(am)ine-5'-phosphate oxidase converts pyridoxine phosphate and pyridoxamine phosphate to pyridoxal phosphate, a cofactor in many metabolic reactions, including neurotransmitter synthesis. (nih.gov)
- A family with a mutation in the pyridox(am)ine-5'-phosphate oxidase gene presenting with neonatal seizures unresponsive to pyridoxine and anticonvulsant treatment but responsive to pyridoxal phosphate is described. (nih.gov)
- Pyridoxal 5′-phosphate oxidase and pyridoxal phosphate phosphatase immunoreactivities were changed in neurons up to 2 days after ischemia, while 4 days after ischemia their immunoreactivities were expressed in astrocytes. (elsevier.com)
- Pyridoxal 5′-phosphate oxidase immunoreactivity and its protein level were highest 12 h after ischemia, while those in pyridoxal phosphate phosphatase were highest 2 days after ischemia. (elsevier.com)
Known as pyridoxal 5-phospha1
- Pyridoxal-phosphate is also known as pyridoxal 5-phosphate or (as we referred to it above) P5P. (anh-usa.org)
Levels of pyridoxal-phosphate1
- Dr. Larsson l inked the effect to bloodstream levels of pyridoxal-phosphate (PLP), the main active coenzyme form of vitamin B6 . (anh-usa.org)
Protein4
- The pyridoxal ring is buried in a nonpolar site containing three aromatic rings while the 5'-phosphate group is highly solvated and makes only three direct contacts to the protein. (ox.ac.uk)
- A pyridoxal-phosphate protein. (genome.jp)
- The encoded protein is allosterically activated by adenosyl-methionine and uses pyridoxal phosphate as a cofactor. (fishersci.com)
- Roscovitine targets, protein kinases and pyridoxal kinase. (harvard.edu)
Phosphatase1
- Encodes RHD4 (ROOT HAIR DEFECTIVE4), a phosphatidylinositol-4-phosphate phosphatase required for root hair development. (or.jp)
Biotin1
- L-Cysteine - Biotin and Pyridoxal 5 Phosphate. (acuriousgeographer.com)
Cofactor pyridoxal4
- The detailed environment of the essential cofactor pyridoxal 5'-phosphate in glycogen phosphorylase b, resulting from crystallographic refinement at 1.9-A resolution, is described. (ox.ac.uk)
- mtClpX activates ALAS by accelerating incorporation of its cofactor, pyridoxal 5'-phosphate (PLP). (elifesciences.org)
- Chick brain GAD proved to be unstable so attempts were made to develop an efficient affinity chromatography procedure (using the cofactor pyridoxal-5-phosphate (PLP) as the ligand) which would enable purification to homogeneity with a minimum number of steps. (bl.uk)
- The complex formed between the C116H mutant and methionine demonstrated that a loop structure (Ala51-Asn64) in the adjacent subunit of the catalytic dimer cannot approach the cofactor pyridoxal 5′-phosphate (PLP) because His116 disrupts the interaction of Asp241 with Lys240, and the liberated side chain of Lys240 causes steric hindrance with this loop. (elsevier.com)
Combination of pyridoxine2
- Pyridoxamine is a chemical combination of pyridoxine and pyridoxal. (healthifybody.com)
- A combination of pyridoxine hydrochloride and pyridoxal-5-phosphate (P5P). (nutricology.com)
Pyridoxamine phosphate1
- During transamination of amino acids, pyridoxal phosphate is transiently converted into pyridoxamine phosphate ( PYRIDOXAMINE ). (bvsalud.org)
Neonatal2
- Pyridoxal phosphate-dependent neonatal epileptic encephalopathy. (medlineplus.gov)
- Pyridoxal phosphate should be considered in neonatal epileptic encephalopathy unresponsive to pyridoxine. (nih.gov)
Inositol1
- Both inositol hexaphosphate and ATP contain phosphate. (vitamin-inspector.com)
Seizures1
- Even though seizures can be controlled with pyridoxal 5'-phosphate, neurological problems such as developmental delay and learning disorders may still occur. (medlineplus.gov)
Phosphorylation2
- Catalyzes the phosphorylation of pyridoxal to PLP in vivo, but shows very low activity compared to PdxK. (uniprot.org)
- An enzyme that catalyzes reversibly the phosphorylation of pyridoxal in the presence of ATP with the formation of pyridoxal 5-phosphate and ADP. (harvard.edu)
Proteins2
- Pyridoxal 5'-phosphate is the metabolically active form of vitamin B6 that has been shown to protect living lipids and proteins against glycation reactions. (royaltyhealth.com)
- The same reaction can also be catalysed by some pyridoxal-phosphate proteins (cf. (genome.jp)
Dependent enzymes2
- Pyridoxal-5'-phosphate dependent enzymes mutation. (receptors.org)
- Aminotransferases share certain mechanistic features with other pyridoxal- phosphate dependent enzymes, such as the covalent binding of the pyridoxal- phosphate group to a lysine residue. (nih.gov)
Gene2
- This is a nuclear gene encoding a mitochondrial enzyme that catalyzes the conversion of 5-phosphonooxy-L-lysine to ammonia, inorganic phosphate, and 2-aminoadipate semialdehyde. (nih.gov)
- From NCBI Gene: This gene encodes a member of the class-V pyridoxal-phosphate-dependent aminotransferase family. (nih.gov)
Acid7
- Background We quantified pyridoxal 5′-phosphate (PLP), pyridoxal (PL), and 4-pyridoxic acid (PA) in paired serum and cerebrospinal fluid (CSF) samples from children and investigated the effect of age on the concentrations and CSF-to-serum ratios of these vitamers. (elsevier.com)
- Treatment with pyridoxal 5′-phosphate into brains (4 μg/5 μl, i.c.v.) at 30 min before transient ischemia protected about 80% of CA1 pyramidal cells 4 days after ischemia and induced elevation of glutamic acid decarboxylase 67 immunoreactivity in the CA1 region. (elsevier.com)
- The chemical reactions and pathways involving the phosphate group, the anion or salt of any phosphoric acid. (mcw.edu)
- In this study the noncompetitive inhibition of the AP5A-induced vasoconstriction with pyridoxal-phosphate-6-azophenyl-2′,4′-disulphonic acid was found to be significantly stronger in MrA than in SEA. (aspetjournals.org)
- The vasoconstriction by the P2X purinoceptor agonist α,β-methylene ATP was inhibited by with pyridoxal-phosphate-6-azophenyl-2′,4′-disulfonic acid and suramin similarly to that induced by AP5A. (aspetjournals.org)
- Jarrow Formulas® Methyl-B12, Methylfolate Plus Pyridoxal-5-Phosphate (P5P) Tablet combines the active forms of these vitamins to support DNA and neurotransmitter synthesis and amino acid metabolism. (herbspro.com)
- 4. Enhancement of 5-Fluorouracil Cytotoxicity by Pyridoxal 5'-Phosphate and Folinic Acid in Tandem. (nih.gov)
Transaminases1
- Discuss the role of pyridoxal phosphate (Vitamin B6) in laboratory testing for transaminases. (aacc.org)
Kinase9
- Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). (uniprot.org)
- Pyridoxal Kinase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (harvard.edu)
- This graph shows the total number of publications written about "Pyridoxal Kinase" by people in Harvard Catalyst Profiles by year, and whether "Pyridoxal Kinase" was a major or minor topic of these publication. (harvard.edu)
- Below are the most recent publications written about "Pyridoxal Kinase" by people in Profiles. (harvard.edu)
- Pyridoxal 5'-phosphate is a slow tight binding inhibitor of E. coli pyridoxal kinase. (harvard.edu)
- Crystal structures of human pyridoxal kinase in complex with the neurotoxins, ginkgotoxin and theophylline: insights into pyridoxal kinase inhibition. (harvard.edu)
- Kinetic and structural studies of the role of the active site residue Asp235 of human pyridoxal kinase. (harvard.edu)
- Crystal Structure of human pyridoxal kinase: structural basis of M(+) and M(2+) activation. (harvard.edu)
- Crystal structure of pyridoxal kinase in complex with roscovitine and derivatives. (harvard.edu)
Physiological2
- These results suggest that the intestine and/or liver play a major role in completely converting physiological amounts of pyridoxamine to circulating pyridoxal, which is then taken up and phosphorylated by other organs. (go.jp)
- Physiological functions: Pyridoxal phosphate acts as a wheal. (cadasb.org)
Zinc1
- Changes in serum copper and zinc during treatment with anticancer drugs interfering with pyridoxal phosphate. (semanticscholar.org)