A potent mutagen and carcinogen. It is a public health concern because of its possible effects on industrial workers, as an environmental pollutant, an as a component of tobacco smoke.
A group of condensed ring hydrocarbons.
7,8,8a,9a-Tetrahydrobenzo(10,11)chryseno (3,4-b)oxirene-7,8-diol. A benzopyrene derivative with carcinogenic and mutagenic activity.
A class of chemicals that contain an anthracene ring with a naphthalene ring attached to it.
Benzopyrenes saturated in any two adjacent positions and substituted with two hydroxyl groups in any position. The majority of these compounds have carcinogenic or mutagenic activity.
A drug-metabolizing, cytochrome P-448 (P-450) enzyme which catalyzes the hydroxylation of benzopyrene to 3-hydroxybenzopyrene in the presence of reduced flavoprotein and molecular oxygen. Also acts on certain anthracene derivatives. An aspect of EC 1.14.14.1.
A major group of unsaturated cyclic hydrocarbons containing two or more rings. The vast number of compounds of this important group, derived chiefly from petroleum and coal tar, are rather highly reactive and chemically versatile. The name is due to the strong and not unpleasant odor characteristic of most substances of this nature. (From Hawley's Condensed Chemical Dictionary, 12th ed, p96)
The products of chemical reactions that result in the addition of extraneous chemical groups to DNA.
Compounds consisting of two or more fused ring structures.
Substances that increase the risk of NEOPLASMS in humans or animals. Both genotoxic chemicals, which affect DNA directly, and nongenotoxic chemicals, which induce neoplasms by other mechanism, are included.
The chemical alteration of an exogenous substance by or in a biological system. The alteration may inactivate the compound or it may result in the production of an active metabolite of an inactive parent compound. The alterations may be divided into METABOLIC DETOXICATION, PHASE I and METABOLIC DETOXICATION, PHASE II.
Chemical agents that increase the rate of genetic mutation by interfering with the function of nucleic acids. A clastogen is a specific mutagen that causes breaks in chromosomes.
Organic compounds that include a cyclic ether with three ring atoms in their structure. They are commonly used as precursors for POLYMERS such as EPOXY RESINS.
A carcinogen that is often used in experimental cancer studies.
Four fused benzyl rings with three linear and one angular, that can be viewed as a benzyl-phenanthrenes. Compare with NAPHTHACENES which are four linear rings.
Tests of chemical substances and physical agents for mutagenic potential. They include microbial, insect, mammalian cell, and whole animal tests.
A liver microsomal cytochrome P-450 monooxygenase capable of biotransforming xenobiotics such as polycyclic hydrocarbons and halogenated aromatic hydrocarbons into carcinogenic or mutagenic compounds. They have been found in mammals and fish. This enzyme, encoded by CYP1A1 gene, can be measured by using ethoxyresorufin as a substrate for the ethoxyresorufin O-deethylase activity.
A by-product of the destructive distillation of coal used as a topical antieczematic. It is an antipruritic and keratoplastic agent used also in the treatment of psoriasis and other skin conditions. Occupational exposure to soots, tars, and certain mineral oils is known to be carcinogenic according to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985) (Merck Index, 11th ed).
A generic grouping for dihydric alcohols with the hydroxy groups (-OH) located on different carbon atoms. They are viscous liquids with high boiling points for their molecular weights.
Organic compounds containing a BENZENE ring attached to a flavone group. Some of these are potent arylhydrocarbon hydroxylase inhibitors. They may also inhibit the binding of NUCLEIC ACIDS to BENZOPYRENES and related compounds. The designation includes all isomers; the 7,8-isomer is most frequently encountered.
A large group of cytochrome P-450 (heme-thiolate) monooxygenases that complex with NAD(P)H-FLAVIN OXIDOREDUCTASE in numerous mixed-function oxidations of aromatic compounds. They catalyze hydroxylation of a broad spectrum of substrates and are important in the metabolism of steroids, drugs, and toxins such as PHENOBARBITAL, carcinogens, and insecticides.
Carcinogenic substances that are found in the environment.
1,2-Benzphenanthrenes. POLYCYCLIC COMPOUNDS obtained from coal tar.
Agents that reduce the frequency or rate of spontaneous or induced mutations independently of the mechanism involved.
A superfamily of hundreds of closely related HEMEPROTEINS found throughout the phylogenetic spectrum, from animals, plants, fungi, to bacteria. They include numerous complex monooxygenases (MIXED FUNCTION OXYGENASES). In animals, these P-450 enzymes serve two major functions: (1) biosynthesis of steroids, fatty acids, and bile acids; (2) metabolism of endogenous and a wide variety of exogenous substrates, such as toxins and drugs (BIOTRANSFORMATION). They are classified, according to their sequence similarities rather than functions, into CYP gene families (>40% homology) and subfamilies (>59% homology). For example, enzymes from the CYP1, CYP2, and CYP3 gene families are responsible for most drug metabolism.
The phenomenon whereby compounds whose molecules have the same number and kind of atoms and the same atomic arrangement, but differ in their spatial relationships. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)
Measurement of the intensity and quality of fluorescence.
A deoxyribonucleotide polymer that is the primary genetic material of all cells. Eukaryotic and prokaryotic organisms normally contain DNA in a double-stranded state, yet several important biological processes transiently involve single-stranded regions. DNA, which consists of a polysugar-phosphate backbone possessing projections of purines (adenine and guanine) and pyrimidines (thymine and cytosine), forms a double helix that is held together by hydrogen bonds between these purines and pyrimidines (adenine to thymine and guanine to cytosine).
Elimination of ENVIRONMENTAL POLLUTANTS; PESTICIDES and other waste using living organisms, usually involving intervention of environmental or sanitation engineers.
A greasy substance with a smoky odor and burned taste created by high temperature treatment of BEECH and other WOOD; COAL TAR; or resin of the CREOSOTE BUSH. It contains CRESOLS and POLYCYCLIC AROMATIC HYDROCARBONS which are CARCINOGENS. It has been widely used as wood preservative and in PESTICIDES and had former use medicinally in DISINFECTANTS; LAXATIVES; and DERMATOLOGIC AGENTS.
A potent epoxide hydrase and aryl hydrocarbon hydroxylase inhibitor. It enhances the tumor-initiating ability of certain carcinogens.
A polyaromatic hydrocarbon inducer of P4501A1 and P4501A2 cytochromes. (Proc Soc Exp Biol Med 1994 Dec:207(3):302-308)
Industrial chemicals which have become widespread environmental pollutants. Each aroclor is a mixture of chlorinated biphenyls (1200 series) or chlorinated terphenyls (5400 series) or a combination of both (4400 series).
Enzymes that catalyze reversibly the formation of an epoxide or arene oxide from a glycol or aromatic diol, respectively.
Cytoplasmic proteins that bind certain aryl hydrocarbons, translocate to the nucleus, and activate transcription of particular DNA segments. AH receptors are identified by their high-affinity binding to several carcinogenic or teratogenic environmental chemicals including polycyclic aromatic hydrocarbons found in cigarette smoke and smog, heterocyclic amines found in cooked foods, and halogenated hydrocarbons including dioxins and polychlorinated biphenyls. No endogenous ligand has been identified, but an unknown natural messenger with a role in cell differentiation and development is suspected.
A circumscribed benign epithelial tumor projecting from the surrounding surface; more precisely, a benign epithelial neoplasm consisting of villous or arborescent outgrowths of fibrovascular stroma covered by neoplastic cells. (Stedman, 25th ed)
An increase in the rate of synthesis of an enzyme due to the presence of an inducer which acts to derepress the gene responsible for enzyme synthesis.
Experimentally induced new abnormal growth of TISSUES in animals to provide models for studying human neoplasms.
Compounds of the general formula R-O-R arranged in a ring or crown formation.
A group of compounds that are derivatives of methoxybenzene and contain the general formula R-C7H7O.
Reduction of pharmacologic activity or toxicity of a drug or other foreign substance by a living system, usually by enzymatic action. It includes those metabolic transformations that make the substance more soluble for faster renal excretion.
A residue of coal, left after dry (destructive) distillation, used as a fuel.
The combination of two or more different factors in the production of cancer.
A nucleoside consisting of the base guanine and the sugar deoxyribose.
Substances which pollute the soil. Use for soil pollutants in general or for which there is no specific heading.
Substances or energies, for example heat or light, which when introduced into the air, water, or land threaten life or health of individuals or ECOSYSTEMS.
Mixture of 2- and 3-tert-butyl-4-methoxyphenols that is used as an antioxidant in foods, cosmetics, and pharmaceuticals.
A chemical by-product that results from burning or incinerating chlorinated industrial chemicals and other hydrocarbons. This compound is considered an environmental toxin, and may pose reproductive, as well as, other health risks for animals and humans.
The rate dynamics in chemical or physical systems.
A family of diphenylenemethane derivatives.
Products of the hydrolysis of chlorophylls in which the phytic acid side chain has been removed and the carboxylic acids saponified.
A hepatic carcinogen whose mechanism of activation involves N-hydroxylation to the aryl hydroxamic acid followed by enzymatic sulfonation to sulfoxyfluorenylacetamide. It is used to study the carcinogenicity and mutagenicity of aromatic amines.
7,12-Dimethylbenzanthracene. Polycyclic aromatic hydrocarbon found in tobacco smoke that is a potent carcinogen.
Benzene derivatives that include one or more hydroxyl groups attached to the ring structure.
Agents that emit light after excitation by light. The wave length of the emitted light is usually longer than that of the incident light. Fluorochromes are substances that cause fluorescence in other substances, i.e., dyes used to mark or label other compounds with fluorescent tags.
Widely distributed enzymes that carry out oxidation-reduction reactions in which one atom of the oxygen molecule is incorporated into the organic substrate; the other oxygen atom is reduced and combined with hydrogen ions to form water. They are also known as monooxygenases or hydroxylases. These reactions require two substrates as reductants for each of the two oxygen atoms. There are different classes of monooxygenases depending on the type of hydrogen-providing cosubstrate (COENZYMES) required in the mixed-function oxidation.
Family of small, surface-dwelling fish that inhabit fresh and brackish waters, and coastal marine areas.
A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.
The relationship between the chemical structure of a compound and its biological or pharmacological activity. Compounds are often classed together because they have structural characteristics in common including shape, size, stereochemical arrangement, and distribution of functional groups.
A serotype of Salmonella enterica that is a frequent agent of Salmonella gastroenteritis in humans. It also causes PARATYPHOID FEVER.
Chemical compounds which pollute the water of rivers, streams, lakes, the sea, reservoirs, or other bodies of water.
Injuries to DNA that introduce deviations from its normal, intact structure and which may, if left unrepaired, result in a MUTATION or a block of DNA REPLICATION. These deviations may be caused by physical or chemical agents and occur by natural or unnatural, introduced circumstances. They include the introduction of illegitimate bases during replication or by deamination or other modification of bases; the loss of a base from the DNA backbone leaving an abasic site; single-strand breaks; double strand breaks; and intrastrand (PYRIMIDINE DIMERS) or interstrand crosslinking. Damage can often be repaired (DNA REPAIR). If the damage is extensive, it can induce APOPTOSIS.
Artifactual vesicles formed from the endoplasmic reticulum when cells are disrupted. They are isolated by differential centrifugation and are composed of three structural features: rough vesicles, smooth vesicles, and ribosomes. Numerous enzyme activities are associated with the microsomal fraction. (Glick, Glossary of Biochemistry and Molecular Biology, 1990; from Rieger et al., Glossary of Genetics: Classical and Molecular, 5th ed)
Naturally occurring complex liquid hydrocarbons which, after distillation, yield combustible fuels, petrochemicals, and lubricants.
A subfamily in the family MURIDAE, comprising the hamsters. Four of the more common genera are Cricetus, CRICETULUS; MESOCRICETUS; and PHODOPUS.
A genus of gram-positive, aerobic bacteria. Most species are free-living in soil and water, but the major habitat for some is the diseased tissue of warm-blooded hosts.
A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
Either of the pair of organs occupying the cavity of the thorax that effect the aeration of the blood.
A group of guanine ribonucleotides in which the phosphate residues of each guanine ribonucleotide act as bridges in forming diester linkages between the ribose moieties.

Platelet high affinity low density lipoprotein binding and import of lipoprotein derived phospholipids. (1/624)

The binding of low density lipoprotein (LDL) to the platelet cell membrane could facilitate the transfer of phospholipids from LDL to the platelets. A polyclonal antibody against the platelet glycoproteins IIb/IIIa inhibited the high affinity binding of 125I-LDL by up to 80%. The transfer of pyrene (py)-labeled sphingomyelin (SM), phosphatidylcholine and phosphatidylethanolamine from LDL to the platelets was unaffected by the antibody. The lectin wheat germ agglutinin (WGA) reduced the binding of 125I-LDL to the platelets by approximately 80%. In contrast, the lectin stimulated the transfer of SM from LDL into the platelets by about three-fold. WGA also specifically augmented the transfer of py-SM between lipid vesicles and the platelets, the stimulation being abolished in the presence of N-acetylglucosamine. Dextran sulfate (DS) increased the specific binding of 125I-LDL to the platelets by up to 2.8-fold. On the other hand, the import of LDL-derived py-phospholipids was unaffected by DS. Together, the results indicate that the phospholipid transfer from LDL to the platelets is independent of the high affinity LDL binding to the platelets and is specifically stimulated by WGA. Thus, the interactions of platelets with LDL phospholipids differ markedly from those with the apoprotein components of the lipoproteins.  (+info)

Characterization of mannooligosaccharide caps in mycobacterial lipoarabinomannan by capillary electrophoresis/electrospray mass spectrometry. (2/624)

A new analytical approach based on capillary electrophoresis-electrospray mass spectrometry (CE/ESI-MS) has provided new insight into the characterization of mannooligosaccharide caps from lipoarabinomannans (LAMs), which are key molecules in the immunopathogenesis of tuberculosis. This analytical approach requires oligosaccharide labeling with the fluorophore 1-aminopyrene-3,6,8-trisulfonate (APTS) by reductive amination at the reducing termini. Optimization of the separation and ionization conditions, such as the choice of capillary electrophoresis (CE) electrolyte buffers, is presented and discussed. Anionic separation of the mono and oligosaccharide APTS derivatives was finally achieved with aqueous triethylammonium formate buffer. It was found that in contrast to the triethylammonium phosphate buffer, the triethylammonium formate buffer was appropriate for CE/ESI-MS coupling analysis of APTS-carbohydrate derivatives. In this case, negative ESI-mass spectra of APTS-carbohydrate adducts showed mainly (M-2H)2-pseudomolecular ions and some sequence fragment ions allowing their non-ambiguous structural characterization at the picomolar level. This analytical approach was successfully applied to more complex mixtures of carbohydrates released by mild acid hydrolysis of the lipoarabinomannans from Mycobacterium bovis BCG. The APTS-mannooligosaccharide cap adducts were separated by CE and their structural characterization achieved by CE/ESI-MS analyses. Mannooligosaccharide caps were routinely analyzed by capillary electrophoresis-laser induced fluorescence (CE-LIF) from 50 fmol of lipoarabinomannans with mannosyl capping (ManLAMs) but sensitivity was about 50 times lower using ESI-MS detection.  (+info)

HPLC/fluorescence determination of anti-BPDE-DNA adducts in mononuclear white blood cells from PAH-exposed humans. (3/624)

The aim of this study was to compare (+/-)-r-7,t-8-dihydroxy-t-9,10-oxy-7,8,9,10-tetrahydrobenzo[a]pyrene (anti-BPDE)-DNA adduct levels in groups of humans subjected to various levels of polycyclic aromatic hydrocarbon (PAH) (benzo[a]pyrene) exposure. An HPLC/fluorescence method was applied to detect specifically anti-BPDE-DNA adducts in mononuclear white blood cells [lymphocyte plus monocyte fraction (LMF)] from humans exposed to PAHs. A total of 130 subjects comprised the sample population: 26 psoriatic patients (3 days after clinical coal tar treatment of the skin), 15 coke oven workers, 19 chimney sweeps, 36 aluminium anode plant workers and 34 non-occupationally PAH-exposed subjects (controls). PAH exposure was assessed in each group by means of the urinary excretion of 1-pyrenol (mean group levels: 1.2, 0.7, 0.3, 65.0 and 0.1 micromol/mol creatinine in coke oven workers, chimney sweeps, aluminium plant anode workers, psoriatic patients and non-occupationally PAH-exposed subjects, respectively). HPLC/fluorescence analysis of BPDE-DNA adducts showed that the percentage of subjects with adduct levels exceeding the 95 percentile control subject value (8.9 adducts/10(8) nucleotides) was significantly high in coke oven workers (46.7%) and chimney sweeps (21.0%) (chi2 test, P < 0.01 and P < 0.05, respectively) but not in aluminium plant workers (11.1%) and psoriatic patients (0%). The increase in BPDE-DNA adduct levels in LMF (Ln values) was significantly related to chronic inhalatory and high PAH exposure (linear multiple regression analysis, F = 6.37, P < 0.01; t = 4.2, P < 0.001). Skin acute (or short-term) and high PAH exposure, charcoal-grilled meat consumption and smoking habit did not seem to influence BPDE-DNA adduct formation in LMF.  (+info)

Comparative metabolism of 1-, 2-, and 4-nitropyrene by human hepatic and pulmonary microsomes. (4/624)

Determining the capability of humans to metabolize the mononitropyrene (mono-NP) isomers 1-, 2-, and 4-NP and understanding which human cytochrome P450 (P450) enzymes are involved in their activation and/or detoxification is important in the assessment of individual susceptibility to these environmental carcinogens. We compared the ability of 15 human hepatic and 8 pulmonary microsomal samples to metabolize each of the three isomers. Human hepatic microsomes were competent in metabolizing all three isomers. Qualitatively similar metabolic patterns were observed, although at much lower levels, upon incubating mono-NP with pulmonary microsomes. Ring-oxidized metabolites (phenols and trans-dihydrodiols) were produced from all three isomers. However, the nitroreductive metabolism leading to the formation of aminopyrene was evident only with 4-NP. The role of specific P450 enzymes in the human hepatic microsomal metabolism of mono-NP was investigated by correlating the P450-dependent catalytic activities in each microsomal sample with the levels of individual metabolites formed by the same microsomes and by examining the effects of agents that can either inhibit or stimulate specific P450 enzymes in mono-NP metabolism. On the basis of these studies, we attribute most of the hepatic microsomal metabolism of 1- and 4-NP to P450 3A4, although a minor role for P450 1A2 cannot be ruled out. Specifically, P450 3A4 was responsible for the formation of 3-hydroxy-1nitropyrene from 1-NP and the formation of trans-9,10-dihydro-9,10dihydroxy-4-nitropyrene, 9(10)-hydroxy-4-nitropyrene, and 4-aminopyrene from 4-NP. None of the P450 enzymes examined (P450s 3A4, 1A2, 2E1, 2A6, 2D6, and 2C9) appeared to be involved in catalyzing the formation of trans-4,5-dihydro-4,5-dihydroxy-2-nitropyrene and 6-hydroxy-2-nitropyrene from 2-NP in human hepatic microsomes. These results, the first report on the comparative metabolism of mono-NP in humans, clearly demonstrate that the role of specific human P450 enzymes in catalyzing oxidative and reductive pathways of mono-NP is dependent upon the position of the nitro group.  (+info)

Genotoxic exposures of potroom workers. (5/624)

OBJECTIVES: Potroom workers in aluminum reduction plants have increased risks for bladder and lung cancer due to exposure from polycyclic aromatic hydrocarbons (PAH). In this study correlations between measures of the external, internal, and biological effective dose have been studied for PAH. METHODS: Venous blood samples were obtained from 98 male potroom workers and 55 unexposed male blue-collar workers, for the analysis of aromatic adducts to DNA (deoxyribonucleic acid) in lymphocytes, using the 32P-postlabeling technique. 1-Hydroxypyrene in urine was analyzed with high-pressure liquid chromatography. Personal sampling of both particulate and gas phase PAH was performed during a full workday for the potroom workers and for 5 referents. Individual PAH congeners were determined with liquid chromatographic-mass spectrometric and gas chromatographic-mass spectrometric techniques. RESULTS: The respiratory-zone airborne level of the sum of 22 particulate (median 13.2 micro/m3) and the 7 gas phase PAH-congeners (median 16.3 microg/m3) among the potroom workers was a hundred times higher than among the referents. The urinary concentration of 1-hydroxypyrene before work was 30 times higher for the potroom workers (median 3.43 micromol/mol creatinine) than for the referents. Most airborne PAH congeners correlated with the excretion of 1-hydroxypyrene in urine. The frequency of aromatic DNA adducts did not, however, differ between the potroom workers and the referents, and no correlation was found for 1-hydroxypyrene in urine. CONCLUSIONS: Despite an obvious occupational exposure to PAH, no increase in aromatic DNA adducts in lymphocytes was found among the potroom workers.  (+info)

Molecular mechanisms of peptide loading by the tumor rejection antigen/heat shock chaperone gp96 (GRP94). (6/624)

Complexes of gp96/GRP94 and peptides have been shown to elicit immunogenicity. We used fluorescence to understand peptide association with gp96. A pyrene-peptide conjugate was complexed with gp96 under a variety of conditions. At room temperature in low salt (20 mM NaCl), the peptide binds gp96 with a strong affinity (approximately 100-150 nM) and forms pyrene excimers, suggesting that the peptides were assembled as dimers. In high salt (2.2 M NaCl), although peptide binding was stronger (Ka approximately 55 nM) than in low salt, pyrene excimers were absent, implying that peptides were farther apart in the complex. Heat shock-activated peptide binding exhibited characteristics of both low salt and high salt modes of binding. Anisotropy and average lifetime of the bound pyrene suggested that peptides were probably located in a solvent-accessible hydrophobic binding pocket in low salt, whereas in high salt, the peptide may be buried in a less hydrophobic (more hydrophilic) environment. These results suggested that peptide-gp96 complexes were assembled in several different ways, depending on the assembly conditions. Resonance energy transfer between the intrinsic tryptophan(s) in gp96 and pyrene suggested that one or more tryptophan residues were within the critical Forster distance of 27-30 A from the pyrene in the bound peptide. It is proposed that peptides are assembled within higher order gp96 complexes (dimers, etc.) in a hydrophobic pocket and that there may be a conformational change in gp96 leading to an open configuration for peptide loading.  (+info)

Pathologic changes induced in respiratory tract mucosa by polycyclic hydrocarbons of differing carcinogenic activity. (7/624)

Seven aromatic polycyclic hydrocarbons (PCHs) were investigated for their toxic effects on respiratory mucosa: benzo(e)pyrene (BeP), pyrene, anthracene, benz(a)anthracene(BaA), dibenz(a,c)anthracene(DBacA), benzo (a)pyrene (BaP), and dimethylbenz(a)anthracene (DMBA). The compounds were chosen because they comprise a spectrum of PCHs ranging from noncarcinogens, to initiators, to weak and strong carcinogens. All of them except DMBA are environmentally relevant chemicals. The chemicals were tested over an 8-week period. Heterotopic tracheal transplants were continously exposed and the histopathologic effects induced by the various PCHs were periodically assessed semiquantitatively. All PCHs exhibited varying degrees of toxicity for respiratory epithelium and submucosa. BeP clearly showed the least toxicity followed by pyrene and anthracene. BaA and DBacA caused marked epithelial and submucosal changes. In addition to epithelial hyperplasia, undifferentiated epithelium and squamous metaplasia developed. Marked mononuclear infiltration occurred in the subepithelial connective tissue. With BaP the epithelial and submucosal changes were similar but were much stronger. DMBA was the most toxic substance, causing epithelial necrosis followed by generalized keratinizing squamous metaplasia; the subepithelial changes consisted of an early acellular exudate and, later (at 8 weeks), marked condensation and hyalinization of the lamina propria. The toxic response pattern of the tracheal mucosa to carcinogenic agents was characterized by the chronicity of epithelial and connective tissue damage, as opposed to the short-lived hyperplastic and inflammatory response elicited by the noncarcinogens and weak initiators.  (+info)

2'-Pyrene modified oligonucleotide provides a highly sensitive fluorescent probe of RNA. (8/624)

Oligonucleotide 9mers containing 2'-O-(1-pyrenylmethyl)uridine [U(pyr)] at the center position were synthesized by using a protected U(pyr) phosphoramidite. The UV melting behaviors indicate that the pyrene-modified oligonucleotides can bind to both their complementary DNA and RNA in aqueous solution. When compared with the unmodified oligonucleotides, the pyrene-modified oligonucleotides showed higher affinity for DNA while exhibiting lower affinity for RNA. The pyrene-modified oligonucleotides in diluted solution exhibited fluorescence typical of pyrene monomer emission [lambdamax 378 (band I) and 391 nm (band III)]. When these oligomers bound to DNA, the fluorescence intensity ratio of band III/band I was increased. With this fluorescence change, a new broad emission (lambdamax 450 nm) due to exciplex between the pyrene and an adjacent nucleobase appeared. In contrast, addition of RNA to the pyrene oligonucleotides resulted in enhancement of the pyrene monomer emission with decrease in the fluorescence band ratio. The extent of the emission enhancement was found to be highly dependent on the nucleobase adjacent to the U(pyr) in the pyrene oligomers. The pyrene oligonucleotide containing dC at the 3'-site of the modification showed remarkable increase (approximately 250 times) in fluorescence (375 nm) upon binding to complementary RNA. The present findings would open the way to the design of a highly sensitive fluorescent probe of RNA.  (+info)

This review exposes the current poor understanding of the internal segmental chain dynamics of dendrimers in solution probed by monitoring the process of excimer formation between pyrene labels covalently attached to the chain ends of dendrimers. The review begins by covering the bases of fluorescence and the kinetics of pyrene excimer formation before describing a procedure based on the Model Free (MF) analysis that is used to analyze quantitatively the fluorescence decays acquired for dendrimers, the ends of which have been fully and covalently labeled with pyrene. Comparison of the various trends obtained by different research groups describing the efficiency of pyrene excimer formation with the generation number of dendrimers illustrates the lack of consensus between the few studies devoted to the topic. One possible reason for this disagreement might reside in the presence of minute amounts of unattached pyrene labels which act as potent fluorescent impurities and affect the analysis of the
Pyrene derivatives can be carcinogenic, teratogenic and mutagenic, thus having the potential to cause malignant diseases. In this work, the interactions of two selected pyrene derivatives (1-OHP and 1-PBO) and human tumor-related DNA (p53 DNA and C-myc DNA) are investigated by spectroscopic and non-native polyacrylamide gel electrophoresis (PAGE) methods. Using fluorescence spectrometry and circular dichroism (CD), DNA interactions of pyrene derivatives are confirmed to occur mainly via the groove binding mode supported by the intercalation into the base pairs of DNA. There is an obvious binding order of pyrene derivatives to the targeted DNA, 1-OHP | 1-PBO. The binding constants of 1-OHP are 1.16 × 106 L×mol−1 and 4.04 × 105 L×mol−1 for p53 DNA and C-myc DNA, respectively, while that of 1-PBO are only 2.04 × 103 L×mol−1 and 1.39 × 103 L×mol−1 for p53 DNA and C-myc DNA, respectively. Besides, the binding of pyrene derivatives to p53 DNA is stronger than that for C-myc DNA. CD and PAGE
1-Nitro[U-4,5,9,10-14C]pyrene was synthesized and administered to male F344 rats by intragastric gavage at a dose of 100 mg/kg of body weight. During the first 48 hr, 41% of the dose was eliminated in the feces, and 16% was eliminated in the urine. The corresponding figures after 120 hr were 51 and 19%. In rats with bile cannulae, 37% of the dose was excreted in the bile after 72 hr, and 6% was excreted in the urine. Fecal metabolites included 1-aminopyrene (isolated amount, 11.7% of the dose), 1-amino-6-hydroxypyrene and 1-amino-8-hydroxypyrene (4.6%), and unchanged 1-nitropyrene (6.6%). 1-Aminopyrene and the 1-aminohydroxypyrenes were identified as their acetyl-derivatives by comparison of their chromatographic retention times, mass spectra, and UV spectra to those of synthetic standards. Biliary metabolites included 1-aminopyrene, 1-amino-6-hydroxypyrene, 1-amino-8-hydroxypyrene, 1-nitro-6(8)-hydroxypyrene, and 1-nitro-3-hydroxypyrene, as well as their glucuronide and sulfate conjugates. The ...
Covalent adducts of the carcinogenic polycyclic aromatic hydrocarbon (+)-anti-benzo[a]pyrene 7,8-dihydrodiol 9,10-epoxide ((+)-anti-BPDE) in polynucleotides have been studied by fluorescence spectroscopy. The pyrenyl chromophores of the BPDE adducts, linked by the C10 atom to the exocyclic nitrogen of guanine, interact in the photoexcited state, as evidenced by excimer fluorescence. Strong BPDE excimer fluorescence is observed in the alternating poly(dGdC).poly(dGdC) sequence, whereas it is weak in the homopolymeric poly(dG).poly(dC) and in calf thymus DNA. No excimer fluorescence is observed for the BPDE adducts in poly(dAdC).poly(dGdT) or poly(dAdG).poly(dCdT). It is concluded that the formation of BPDE excimers in polynucleotides requires binding to guanines on different strands on consecutive basepairs. The experimental results are supported by graphics modeling and energy minimization of BPDE adducts in various oligonucleotide sequences. The results show that the most favorable arrangement for
Excimers play a key role in a variety of excited-state processes, such as exciton trapping, fluorescence quenching, and singlet-fission. The dynamics of benzene excimer formation in the first 2 ps after S1 excitation from the parallel-displaced geometry of the benzene dimer is reported here. It was simulated Photodissociation and reaction dynamics 2018 PCCP HOT Articles
A new N-thiophosphorylated thiourea (1-pyrene)NHC(S)NHP(S)(OiPr)2 (HL) has been synthesized. The molecular structure of HL was elucidated by X-ray diffraction revealing a linear intramolecular hydrogen bond. Additionally, its crystal structure is stabilized by two intermolecular hydrogen bonds, which in turn
The rate parameters of solvent-solute energy transfer and of oxygen-solvent quenching have been determined for solutions of 2, 5-diphenyloxazole in benzene, toluene, p-xylene and mesitylene. The role of excited molecules and excimers in transfer to the solute molecules is considered in terms of the Voltz relations, which include the Förster critical transfer distance, the molecular diffusion coefficients, and the solvent excitation migration coefficient. It is proposed that the migration is due to excimer formation and dissociation, and that the energy transfer occurs by a diffusion/migration-controlled collisional process. Dilution of the solvent decreases the migration, but increases the transfer distance, so that the transfer efficiency remains practically constant. The excimer formation and dissociation rate parameters in the pure alkyl benzenes are evaluated. ...
TY - JOUR. T1 - A dipyrenyl calixazacrown chemosensor for Mg2+ AU - Hamdi, Abdelwaheb. AU - Kim, Sang Hoon. AU - Abidi, Rym. AU - Thuéry, Pierre. AU - Kim, Jong Seung. AU - Vicens, Jacques. PY - 2009/4/4. Y1 - 2009/4/4. N2 - A new fluorogenic calix[4]tetraaza-crown-6 (4) bearing two pyrene amide groups has been prepared. It was shown to be selective for Mg2+. When Mg2+ is bound to 4, the pyrene monomer emission increased while the excimer emission declined in a ratiometric manner. It is shown by 1H NMR that this ratiometric change is due to the conformational changes of the pyrenes during the chelation of Mg2+ by the amide functions to form a 1:1 complex.. AB - A new fluorogenic calix[4]tetraaza-crown-6 (4) bearing two pyrene amide groups has been prepared. It was shown to be selective for Mg2+. When Mg2+ is bound to 4, the pyrene monomer emission increased while the excimer emission declined in a ratiometric manner. It is shown by 1H NMR that this ratiometric change is due to the ...
Precautionary Statements: P260-P271-P304+P340-P312-P314-P501c Do not breathe dust/fume/gas/mist/vapours/spray. Use only outdoors or in a well-ventilated area. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Call a POISON CENTER or doctor/physician if you feel unwell. Get medical advice/attention if you feel unwell. Dispose of contents/ container to an approved waste disposal plant ...
The report generally describes cyclopenta[c,d]pyrene, examines its uses, production methods, patents. Cyclopenta[c,d]pyrene market situation is overviewed;
Mitch Winnik received a B.A. degree from Yale University in 1965. He obtained his Ph.D. degree in the area of organic chemistry at Columbia University in 1969, working under the direction of Prof. Ronald Breslow, and then spent a year as a postdoctoral fellow in the laboratory of Prof. George Hammond at Caltech studying organic photochemistry. He joined the faculty at the University of Toronto in 1970, and received tenure as an organic chemist. On his first sabbatical, in Bordeaux France, he realized that he was bored with what he had been doing and decided to switch his attention to longer molecules. Upon his return to Toronto, he and his coworkers prepared a series of polymers with a pyrene group at both ends. The pyrene groups emit a blue fluorescence if the pyrenes are far apart, but if an excited pyrene during its lifetime can find a second pyrene, they form a sandwich structure which emits a green excimer fluorescence. In dilute solution, the rate of excimer formation from the ...
The rates of interactions of polycyclic aromatic hydrocarbons (PAHs) with biological cells studied with fluorescence appear to be different for cells from different origins. The monomer emission of benzo[,i,a,/i,]pyrene (BaP) is enhanced as in liposomes, but more significantly in normal liver cells than in liver cancer cells or kidney cells, and that enhancement is proportional to the amount of cells added. When PAHs are allowed to interact with cells for a certain period of time, metabolism appears to occur. The excimer emission is seen to dissipate continuously as reactions proceed, whereas the monomer emission increases, passes through a maximum, then starts to decrease when excimer emission becomes exhausted. The time plot of the BaP excimer emission in semilogarithmic coordinates indicates that the decrease or the mass transfer of microcrystalline BaP to the cell membrane is a first-order process. Metabolism has been investigated by monitoring the monomer emission. Liver cells have higher ...
The fluorescence lifetimes of a number of aromatic hydrocarbons are shortened by 15-40% when the matrix is compressed by 30 kbar pressure. The causes of environmentally-induced lifetime shortening may be further illuminated by a detailed study of one solute under a variety of conditions. The document reports on such a study of pyrene and in addition, compares the pressure-enhanced electronic relaxation for the monomeric and excimeric forms of pyrene. The work established the magnitude of environmental influences on the singlet lifetime of pyrene and demonstrated a remarkable insensitivity of the emitting species to the nature of the microscopic surroundings, be it monomer or excimer.(*POLYCYCLIC COMPOUNDS
TY - JOUR. T1 - CYP1A1, GSTM1, and GSTP1 genetic polymorphisms and urinary 1-hydroxypyrene excretion in non-occupationally exposed individuals. AU - Nerurkar, P. V.. AU - Okinaka, L.. AU - Aoki, C.. AU - Seifried, A.. AU - Lum-Jones, A.. AU - Wilkens, L. R.. AU - Le Marchand, L.. PY - 2000. Y1 - 2000. N2 - The CYP1A1 and glutathione S-transferase enzymes (e.g., GSTM1 and GSTP1) are involved in the activation and conjugation of polycyclic aromatic hydrocarbons (PAHs), respectively, and are controlled by genes that are polymorphic. The CYP1A1*2 allelic variant has been associated with elevated urinary 1-hydroxypyrene (1-OHP), a proposed marker for internal dose of activated PAHs, in coke-oven workers. We investigated whether this association could be observed at low exposure levels, such as those experienced by the general population. We conducted a cross-sectional study among 188 individuals (106 Japanese, 60 Caucasians, and 22 Hawaiians) who were selected as controls in a population-based ...
Pyrene is a fluorescent polycyclic aromatic hydrocarbon. It is useful as a proximity sensor - when two pyrene residues are spaced close to each other, they exhibit easily detectable excimer fluorescence.
Hatanaka N, Yamazaki H, Oda Y, Guengerich FP, Nakajima M, Yokoi T: Metabolic activation of carcinogenic 1-nitropyrene by human cytochrome P450 1B1 in Salmonella typhimurium strain expressing an O-acetyltransferase in SOS/umu assay. Mutat Res. 2001 Oct 18;497(1-2):223-33. doi: 10.1016/s1383-5718(01)00254-6. [PubMed:11525925 ...
4-Nitropyrene was tested for carcinogenicity in newborn rats by subcutaneous injection, producing an increase in the incidence of mammary tumours. It was also tested by intraperitoneal injection in newborn mice, producing an increase in the incidence of liver-cell tumours in males and of lung tumours in animals of each sex. A study by intraperitoneal injection was inadequately reported ...
4FBT: Structural mechanism of replication stalling on a bulky amino-polycyclic aromatic hydrocarbon DNA adduct by a y family DNA polymerase.
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102859-52-9 - SQAFYTHBQZQFLZ-UHFFFAOYSA-N - Cyclopenta(cd)pyrene, 4-nitro- - Similar structures search, synonyms, formulas, resource links, and other chemical information.
Phenylethynylpyrene (PEP) is a pyrene derivative with red-shifted absorption and emission spectra. Fits blue channel of qPCR instruments, can be used for multiplex experiments.
Affiliation:香川医科大学,医学部,副学長, Research Field:病院管理学, Keywords:1-nitropyrene,大気中粒子状物質,エアロゾル,変異原性,大気汚染,粒子,benzo(a)pyrene,DNA付加体,ダイオキシン,1、6-dinitropyrene, # of Research Projects:6, # of Research Products:0
Product Name: 1-HydroxypyreneFormula: C16H10OWeight: 218.25SMILES: OC1C2C3=C4C(C=CC=C4C=CC3=CC=1)=CC=2CAS NO: 917497-70-2 Product: SC144 (hydrochloride)
TY - JOUR. T1 - Association between polycyclic aromatic hydrocarbon exposure and peripheral blood mononuclear cell DNA damage in human volunteers during fire extinction exercises. AU - Andersen, Maria Helena Guerra. AU - Saber, Anne Thoustrup. AU - Clausen, Per Axel. AU - Pedersen, Julie Elbæk. AU - Løhr, Mille. AU - Kermanizadeh, Ali. AU - Loft, Steffen. AU - Ebbehøj, Niels. AU - Hansen, Åse Marie. AU - Pedersen, Peter Bøgh. AU - Koponen, Ismo Kalevi. AU - Nørskov, Eva-Carina. AU - Møller, Peter. AU - Vogel, Ulla Birgitte. PY - 2018. Y1 - 2018. N2 - This study investigated a number of biomarkers, associated with systemic inflammation as well as genotoxicity, in 53 young and healthy subjects participating in a course to become firefighters, while wearing personal protective equipment (PPE). The exposure period consisted of a 3-day training course where the subjects participated in various live-fire training exercises. The subjects were instructed to extinguish fires of either wood or wood ...
The Koggala lagoon is a coastal wetland affected by a major oil spill and other anthropogenic pollution sources. In this study, gill and liver histological alterations and polycyclic aromatic hydrocarbon (PAH) exposure indicative bile fluorescence patterns of the fish species inhabiting the lagoon were examined in order to explore the potential biological impacts. Fixed wavelength fluorescence patterns in the bile of Mugil cephalus, Lutjanus russellii and Etroplus suratensis showed bioavailability of naphthalene type-, phenanthrene type-, pyrene type- and benzo(a)pyrene type- metabolites indicating recent exposure of the fishes to petrogenic and pyrogenic PAHs. Histological analysis revealed the occurrence of prominent gill and liver lesions, especially in the tissues of M. cephalus and L. russellii. Of the fish species examined, which included 43 individual fishes, the liver tissues of M. cephalus (two fish) and L. russellii (one fish) displayed foci of hepatocellular alterations with nodular ...
Our findings suggest that the association between PAH exposure and a cytokine storm may be mediated by AhR and NLRP3 expression among preschoolers.
Cell-penetrating peptides (CPPs) are membrane permeable vectors recognized for their intrinsic ability to gain access to the cell interior. The hydrophobic counter-anion, pyrenebutyrate, enhances cellular uptake of oligoarginine CPPs. To elucidate CPP uptake mechanisms, the effect of pyrenebutyrate on well-recognized CPPs with varying hydrophobicity and arginine content is investigated. The cellular CPP uptake and CPP-mediated oligonucleotide delivery is analyzed by fluorescence activated cell sorting, confocal microscopy, and a cell-based splice-switching assay. The splice-switching oligonucleotide is a mixmer of 2-O-methyl RNA and locked nucleic acids delivered as a non-covalent complex with 10-fold molar CPP excess. CPP-induced membrane perturbation on large unilamellar vesicles is investigated in calcein release experiments. We observed that pyrenebutyrate facilitates cellular uptake and translocation of oligonucleotide mediated by oligoarginine nonamer while limited effect of pyrenebutyrate on
A novel method based on the steady state fluorescence technique was used to study the sol-gel transition in the free radical crosslinking reaction between styrene (St) and divinyl benzene (DVB) with 2,2-azobisisobutyronitrile (AIBN) as initiator. N-(4-(pyrenyl methylene)-oxy-carbonyl phenyl)maleimide (Py-MI) was used as a fluorescence probe. The possible enchainment of Py-MI in alternating sequences occurred randomly in polymer clusters produced modifications in the fluorescence spectra, namely the shift at the higher wavelengths due to the excimer formation. The fluorescence spectra of Py-MIs excimers allowed both to monitor the sol-gel transition and to test the critical exponents as function of co-monomers concentration. The gel fraction exponent beta and the weight average degree of polymerization exponent gamma agreed best with the static percolation values. Although this technique was applied for St-DVB co-polymerization, it may be generalized for the other monomers that are able to ...
Characterization of a pyrene-degrading Mycobacterium sp. strain CH-2.: Mycobacterium sp strain CH-2 was isolated from a manufactured gas plant contaminated with
A new approach is presented to obtain fluorescent sensors for pH windows that work in water and under biomimetic conditions. A single molecule that features all-covalently linked components is used, thus making it capable of working as a fluorescent sensor with an OFF/ON/OFF response to pH value. The components are a tertiary amine, a pyridine, and a fluorophore (pyrene). The forms with both protonated bases or both neutral bases quench the pyrene fluorescence, whereas the form with the neutral pyridine and protonated amine groups is fluorescent. The molecular sensor is also equipped with a long alkyl chain to make it highly hydrophobic in all its protonated and unprotonated forms, that is, either when neutral or charged. Accordingly, it can be confined at any pH value either in traditional (i.e., low-molecular-weight) nonionic surfactant micelles or inside polymeric, biocompatible micellar containers. Relevant for future applications in vivo, thanks to its strong hydrophobicity, no leakage of ...
We made two important contributions to this field. First, we developed a method based upon pyrene fluorescence, to determine the critical aggregation concentration for polymers in water. [see Macromolecules, 24, 1033-1040 (1991)] This is our most cited paper because it shows how one can distinguish between the true CAC and a partition equilibrium that might resemble the CAC. The second contribution is more subtle. We showed, for the case linear PEO with C16H33- end groups where the rheological behavior is remarkably simple, that flower-like micelles exist at low concentration, and undergo a transition to bridged micelles as higher concentrations. [see Macromolecules, 25, 7024-7030 (1992)] More important, we showed that both shear and extensional flow induced a bridge-to-loop transition of the PEO, leading to smaller structures, and lower solution viscosity, and throughout this transition, the mean size of the individual micelles (20 C16 chains per micelle) was unaffected. [see Langmuir, 9, ...
Polycyclic aromatic hydrocarbons (PAHs) are by-products of combustion. There are a large number of compounds that are classified as PAHs; some, such as benzo(a)pyrene, are carcinogenic. We have published research showing that pyrene is a good generic marker of PAH exposure and that urinary 1-hydroxypyrene is a suitable biomarker. HSE has set a GB guidance value for 1-hydroxypyrene in urine (4 µmol/mol creatinine).. Product Code: PE11630. Price: £58.00 (VAT free). ...
A new imaging contrast agent is reported that provides an increased fluorescent signal upon application of ultrasound (US). Liposomes containing lipids labelled with pyrene were optically excited and the excimer fluorescence emission intensity was detected in the absence and presence of an ultrasound field using an acousto-fluorescence setup. The acousto-fluorescence dynamics of liposomes containing lipids with pyrene labelled on the fatty acid tail group (PyPC) and the head group (PyPE) were compared. An increase in excimer emission intensity following exposure to US was observed for both cases studied. The increased intensity and time constants were found to be different for the PyPC and PyPE systems, and dependent on the applied US pressure and exposure time. The greatest change in fluorescence intensity (130%) and smallest rise time constant (0.33 s) are achieved through the use of PyPC labelled liposomes. The mechanism underlying the observed increase of the excimer emission intensity in ...
PMID 16864595] The influence of genetic polymorphisms in Ahr, CYP1A1, CYP1A2, CYP1B1, GST M1, GST T1 and UGT1A1 on urine 1-hydroxypyrene glucuronide concentrations in healthy subjects from Rio Grande do Sul, Brazil. ...
EWGs Tap Water Database Benzo[a]pyrene results for Terra Nova Mobile Home Park | Benzo[a]pyrene. Find out what is in your tap water
Cells derived from mixed Syrian hamster embryo cultures were treated with pyrene (control) or with benzo[a]pyrene. Transformed clones were obtained only with the carcinogen. Some of the transformed clones were responsible for cell lines that produced tumors when injected into hamsters. These observations provide evidence that chemical-induced oncogenesis can be studied by an in vitro model. ...
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A new heterometallic diruthenium(III)-magnesium(II) complex functionalized with four pyrenecarboxylate fluorophores ,b,1,/b, has been synthesized and structurally characterized. Fluorescence from the pyrene moieties in ,b,1,/b, was nearly completely quenched in CH,sub,2,/sub,Cl,sub,2,/sub, (,98%), but turn-on fluorescence was successfully observed after regioselective substitution of the carboxylates bridging the heterometallic Ru(III)···Mg(II) sites.. ...
Under EPAs Guidelines for Carcinogen Risk Assessment (U.S. EPA, 2005a), benzo[a]pyrene is carcinogenic to humans based on strong and consistent evidence in animals and humans ...
Backer, J M. and Weinstein, I B., Interaction of benzo(a)pyrene and its dihydrodiol-epoxide derivative with nuclear and mitochondrial dna in c3h10t1/2 cell cultures. (1982). Subject Strain Bibliography 1982. 181 ...
benzo[a]pyrene | C20H12 | CID 2336 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.
Rigdon, R H.; Benge, M C.; Kirchoff, H; Mack, J; and Neal, J, Leukemia in mice fed benzo(a)pyrene, a clinical, pathologic and hematologic study. (1969). Subject Strain Bibliography 1969. 1799 ...
Page contains details about [email protected](1,6-bis(4-(((pyridin-2-yl)methylidene)amino)phenyl)pyrene)6(NTf2)8 . It has composition images, properties, Characterization methods, synthesis, applications and reference articles : nano.nature.com
1,2-Epoxy-1,2,3,4-tetrahydrodibenzo(a,h)pyrene | C24H16O | CID 54292 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.
3-Methoxybenzo[a]pyrene/ACM63059687 can be provided in Alfa Chemistry. We are dedicated to provide our customers the best products and services.
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RE: New COKE formula.. We were discussing this the other evening, and someone came up with an interesting thoery.. Seems that COKE signed a contract in the early 1900s with their original distributors to sell their original formula for a fixed price (a price cap). Since then inflation has really hit hard, and COKE has been actively buying distributors for the last few years to get rid of the contracts, and then reselling the distributorships at terms more lucrative to COKE.. However, if they change the formula, then the agreement no longer applies. COKE can afford to lose market share, and still make larger profits. The only ones who lose are the consumers and the distributors.. Some of this is verifiable, some is pure conjecture. Treat this as net.rumor.. Jay ...
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A device for measuring a shape of a wall portion of an oven, such as a coke oven, the device comprising: - a box (20) having a main part (38) defining at least one opening (44) and a closing system (40) movable with respect to the main p ...
NICE has taken the fizz out of its good advice to parents to not run to us about juniors squits by vetoing flat coke or juice as a helpful remedy. Based on what evidence, asks Copperfield.
pictorialization genealogical unpaled arriswise subinfeudate undercrust preconfiguration fanlike autolaryngoscope Kalmarian textarian Lycian preambition preintercourse coke Hazara semisupination Anomodontia conglobately [email protected] ...
benz[a]pyrene. 3,4-benzpyrene. 3,4-benzopyrene. 3,4-benz[a]pyrene. 3,4-benzo[a]pyrene ... "benzo[a]pyrene". pubchem.ncbi.nlm.nih.gov.. *^ Assessment of Benzo-alpha-pyrene Emissions in the Great Lakes Region, pp 23-24 ... Benzo[a]pyrene is first oxidized by cytochrome P450 1A1 to form a variety of products, including (+)benzo[a]pyrene-7,8-epoxide. ... Benzo[a]pyrene, showing the base pyrene ring and numbering and ring fusion locations according to IUPAC nomenclature of organic ...
benz[a]pyrene. 3,4-benzpyrene. 3,4-benzopyrene. 3,4-benz[a]pyrene. 3,4-benzo[a]pyrene. pentacyclo[10.6.2.02,7.09,19.016,20] ... "benzo[a]pyrene". pubchem.ncbi.nlm.nih.gov.. *^ Assessment of Benzo-alpha-pyrene Emissions in the Great Lakes Region, pp 23-24 ... Benzo[a]pyrene is first oxidized by cytochrome P450 1A1 to form a variety of products, including (+)benzo[a]pyrene-7,8-epoxide. ... Benzo[a]pyrene, showing the base pyrene ring and numbering and ring fusion locations according to IUPAC nomenclature of organic ...
... ranged from 6 to 88 mg/kg and fluoranthene and pyrene were generally the most abundant PAHs.[63] Benzo[a]pyrene (BaP), the most ... An adduct formed between a DNA strand and an epoxide derived from a benzo[a]pyrene molecule (center); such adducts may ... Mutagenic PAHs, such as benzo[a]pyrene, usually have four or more aromatic rings as well as a "bay region", a structural pocket ... Polycyclic aromatic hydrocarbons (e.g., 3-methylcholanthrene, benzo[a]pyrene, benzanthracenes, benzoflavones (e.g., beta- ...
Pyrenes with thick walls. The generic name Lasianthus is derived from the Greek lasios, "shaggy, velvety, hairy", and anthos, " ...
Benzo(a)pyrene " 0.010 μg/l 0.2 μg/l 0.0028 μg/l " ...
Mineralizes phenanthrene, fluoranthene, and pyrene, but not anthracene or benzo[a]pyrene. Differential characteristics The ... Etymology: pyrenivorans; digesting pyrene. Microscopy Gram-positive, acid-fast rods. Colony characteristics The rough colonies ...
In 1911, Pyrene patented a small, portable extinguisher that used the chemical. The extinguisher consisted of a brass bottle ... "Pyrene Fire Extinguishers". Vintage Fire Extinguishers. Archived from the original on 25 March 2010. Retrieved 23 December 2009 ... the Pyrene Manufacturing Company of Delaware filed a patent to use carbon tetrachloride to extinguish fires. The liquid was ...
Z. f. pyrenes Verity, 1921. *Z. f. seeboldi Oberthur, 1910. *Z. f. siciliensis Verity, 1917 ...
"Piquentum Wines". Les Caves de Pyrene. 2018-01-23. "The influence of yeasts type and malolactic fermentation on the quality of ...
Mistry, A. (31 May 2012). "Dehydration of 3,4-dihydro-5H-Benzo[cd]pyren-5-ol; 6H-Benzo[cd]pyrene". ChemSpider. Royal Society of ... The synthesis starts using a Wittig reaction of pyrene carboxaldehyde. To obtain the ylide needed, firstly triphenyl phosphine ... pyrenes". Chemistry: A European Journal. 21 (5): 2011-2018. doi:10.1002/chem.201404877. Palmer, J. (28 May 2012). "'Olympic ...
... degrades pyrene. Parte, A.C. "Bowmanella". LPSN. "Bowmanella pacifica Taxon Passport - StrainInfo". www. ... nov., isolated from a pyrene-degrading consortium". International Journal of Systematic and Evolutionary Microbiology. 59 (7): ...
"All you needed to know about qvevri but were afraid to ask". Les Caves De Pyrene. Retrieved Oct 6, 2019.. ...
Fruit is a globose drupe with 5 pyrenes. Source: Hindi - Nalbila Marathi - Ranabili, Gudmai Tamil - Puilipan cheddi, ...
Four higher annellated pyrenes with acene character". Journal of the Chemical Society (Resumed): 2681. doi:10.1039/JR9570002681 ...
pyrene as its sodium saltt. Perylene in the form of its alkali metal (M = Li, Na, Cs) etherates. Cyclooctatetraene is reduced ... Ease of formation is in the order benzene < naphthalene < anthracene < pyrene, etc. Salts of the radical anions are often not ... Kucera, Benjamin E.; Jilek, Robert E.; Brennessel, William W.; Ellis, John E. (2014). "Bis(pyrene)metal complexes of vanadium, ... niobium and titanium: Isolable homoleptic pyrene complexes of transition metals". Acta Crystallographica Section C Structural ...
Hand propelled Pyrene fire extinguisher. Shand Mason horse-drawn fire engine. Shand Mason horse-drawn steam pump BOR 316 Dennis ...
Crystal and molecular structure of a benzo-a-pyrene 7,8-diol 9,10-epoxide N2-deoxyguanosine adduct: Absolute configuration and ... Dietary exposure estimation of benzo[a]pyrene and cancer risk assessment. Journal of Toxicology and Environmental Health Part A ... Kazerouni N, Sinha R, Hsu CH, Greenberg A, Rothman N. Analysis of 200 food items for benzo[a]pyrene and estimation of its ... Aygün SF, Kabadayi F. Determination of benzo[a]pyrene in charcoal grilled meat samples by HPLC with fluorescence detection. ...
Klankeo, Piriya; Nopcharoenkul, Wannarak; Pinyakong, Onruthai (2009). "Two novel pyrene-degrading Diaphorobacter sp. and ...
Theoretical and experimental studies on pyrene derivatives". Afterwards, she worked as a scientist at the European Synchrotron ...
nov., isolated from a pyrene-degrading consortium". International Journal of Systematic and Evolutionary Microbiology. 59 (7): ...
Bebryx was also the father of Pyrene. Strabo 7.3.2 Sergent 1988, pp. 345-350. Delamarre 2003, p. 69: "B. Sergent a démontré de ...
... is a hydrocarbon similar to pyrene. Single bonds with hydrogen replace the double bonds in the benzene rings. ...
nov., isolated from a pyrene-degrading consortium". International Journal of Systematic and Evolutionary Microbiology. 61 (Pt 6 ...
The fruit matures black or brown, separating into four corky pyrenes. Volkameria aculeata and Volkameria glabra are grown as ...
... is prepared by oxidation of pyrene. Typical oxidants are chromic acid and chlorine. The ...
It is a structural isomer of the alternant PAH pyrene. It is not as thermodynamically stable as pyrene. Its name is derived ...
... is a pyrene-degrading marine gammaprotobacterium. It is of the genus Alcanivorax, a group of marine ... nov., isolated from a deep-sea pyrene-degrading consortium". International Journal of Systematic and Evolutionary Microbiology ... nov., isolated from a deep-sea pyrene-degrading consortium". International Journal of Systematic and Evolutionary Microbiology ...
Benzo[α]pyrene interacts with deoxyguanosine of the DNA, damaging it and potentially starting the processes that can lead to ... pyrene. DNA consists of sequences of four bases - guanine, adenine, cytosine, and thymine - bound to a deoxyribonucleic ...
nov., isolated from a pyrene-degrading microbial enrichment, and emended description of the genus Parapedobacter". ... Parapedobacter pyrenivorans has the ability to degrade pyrene. Parte, A.C. "Parapedobacter". LPSN. "Parapedobacter pyrenivorans ...
Rentz JA, Alvarez PJ, Schnoor JL (February 2008). "Benzo[a]pyrene degradation by Sphingomonas yanoikuyae JAR02". Environmental ...
benz[a]pyrene. 3,4-benzpyrene. 3,4-benzopyrene. 3,4-benz[a]pyrene. 3,4-benzo[a]pyrene ... "benzo[a]pyrene". pubchem.ncbi.nlm.nih.gov.. *^ Assessment of Benzo-alpha-pyrene Emissions in the Great Lakes Region, pp 23-24 ... Benzo[a]pyrene is first oxidized by cytochrome P450 1A1 to form a variety of products, including (+)benzo[a]pyrene-7,8-epoxide. ... Benzo[a]pyrene, showing the base pyrene ring and numbering and ring fusion locations according to IUPAC nomenclature of organic ...
benz[a]pyrene. 3,4-benzpyrene. 3,4-benzopyrene. 3,4-benz[a]pyrene. 3,4-benzo[a]pyrene. pentacyclo[10.6.2.02,7.09,19.016,20] ... "benzo[a]pyrene". pubchem.ncbi.nlm.nih.gov.. *^ Assessment of Benzo-alpha-pyrene Emissions in the Great Lakes Region, pp 23-24 ... Benzo[a]pyrene is first oxidized by cytochrome P450 1A1 to form a variety of products, including (+)benzo[a]pyrene-7,8-epoxide. ... Benzo[a]pyrene, showing the base pyrene ring and numbering and ring fusion locations according to IUPAC nomenclature of organic ...
Pyrene was first isolated from coal tar, where it occurs up to 2% by weight. As a peri-fused PAH, pyrene is much more resonance ... Pyrenes fluorescence emission spectrum is very sensitive to solvent polarity, so pyrene has been used as a probe to determine ... Experiments in pigs show that urinary 1-hydroxypyrene is a metabolite of pyrene, when given orally. Pyrenes are strong electron ... Pyrene and its derivatives are used commercially to make dyes and dye precursors, for example pyranine and naphthalene-1,4,5,8- ...
Other names: «beta»-Pyrene; Benzo[def]phenanthrene; Pyren; Coal tar pitch volatiles:pyrene ...
Pyrene punctata Willan, 2001. Retrieved through: World Register of Marine Species on 29 January 2011. "Pyrene punctata". ... Pyrene punctata, common name : the telescoped dove shell, is a species of sea snail, a marine gastropod mollusk in the family ...
Other names: Benz[a]pyrene; 1,2-Benzpyrene; 3,4-Benzopyrene; 3,4-Benzpyrene; 3,4-Benz[a]pyrene; 6,7-Benzopyrene; Benzo[d,e,f] ... The pyrene series, Tetrahedron, 1979, 35, 1027. [all data] Akiyama, Li, et al., 1979. Akiyama, I.; Li, K.C.; LeBreton, P.R.; Fu ... The ground-state electronic structure of aryloxiranes and metabolites of benzo[a]pyrene, J. Phys. Chem., 1979, 83, 2997. [all ...
... is a pyrenes (CHEBI:59659) ... Benzo[a]pyrene-7,8-dihydrodiol KEGG COMPOUND Benzo[a]pyrene-7,8 ... CHEBI:34562 - Benzo[a]pyrene-7,8-diol. Main. ChEBI Ontology. Automatic Xrefs. Reactions. Pathways. Models. ...
pyrene synonyms, pyrene pronunciation, pyrene translation, English dictionary definition of pyrene. n. The stone of certain ... pyrene. Also found in: Thesaurus, Encyclopedia, Wikipedia. py·rene 1. (pī′rēn′, pī-rēn′). n.. The stone of certain fruits, such ... pyrene, benzo(a)anthracene, chrysene, benzo(b) fluoranthene, benzo(a)pyrene, indeno(1,2,3-cd) pyrene, and benzo(g,h,i)perylene ... pyrene; benz[a]anthracene; chrysene; benzo[k] fluoranthene; benzo[b]fluoranthene; benzo[a]pyrene; indeno[1, 2,3-cd]pyrene; ...
The National Institute of Standards and Technology (NIST) uses its best efforts to deliver a high quality copy of the Database and to verify that the data contained therein have been selected on the basis of sound scientific judgment. However, NIST makes no warranties to that effect, and NIST shall not be liable for any damage that may result from errors or omissions in the Database ...
Analytical Chemistry Molecular Structure Pyrene Fluorescence Spectrum Translated from Zhurnal Prikladnoi Spektroskopii, Vol. 43 ...
This chapter provides the diffusion coefficient of pyrene in octane at infinite dilution for various temperature and pressure ... Winkelmann J. (2018) Diffusion coefficient of pyrene in octane at infinite dilution. In: Lechner M.D. (eds) Diffusion in Gases ... This chapter provides the diffusion coefficient of pyrene in octane at infinite dilution for various temperature and pressure ...
... pyrene. Find out what is in your tap water ... pyrene results for Owensboro Municipal Utilities , Benzo[a] ... Benzo[a]pyrene. Owensboro Municipal Utilities. Benzo[a]pyrene is a polycyclic aromatic hydrocarbon, or PAH, released from ... The EWG Health Guideline of 0.007 ppb for benzo[a]pyrene was defined by the California Office of Environmental Health Hazard ... The legal limit for benzo[a]pyrene, established in 1992, was based on analytical detection limits at the time that the standard ...
... pyrene (192654) was prepared for the NIOSH criteria documentation program. Those items that are preceeded by a number are ... This preliminary bibliography on dibenzo(a,e)pyrene (192654) was prepared for the NIOSH criteria documentation program. Those ...
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... pyrene , C21H14O , CID 92049 - structure, chemical names, physical and chemical properties, classification, patents, literature ...
Tag Archives: benzo[a]pyrene. The Dose Makes the Poison - or does it?. By Kacee Deener ... Tagged 1, 4-dioxane (inhalation update), benzo[a]pyrene, biphenyl, ETBE, ethylene oxide, formaldehyde, Gina McCarthy, health ... Until then, check out an example of dose-response assessment in Section 2 of the IRIS assessment of benzo[a]pyrene. And read ... Tagged benzo[a]pyrene, dose response, EPAs Integrated Risk Information System (IRIS) Program, exposure, Human Health Risk ...
Comparison of phenanthrene and pyrene degradation by different wood-decaying fungi.. Sack U1, Heinze TM, Deck J, Cerniglia CE, ... Phenanthrene and pyrene metabolites were purified by high-performance liquid chromatography and identified by UV absorption, ... The degradation of phenanthrene and pyrene was investigated by using five different wood-decaying fungi. After 63 days of ... No 14CO2 evolution was detected in either [14C]phenanthrene or [14C]pyrene liquid cultures of Flammulina velutipes, Laetiporus ...
... A. S. Oliveira,1 ... Photodegradation study of pyrene adsorbed onto microcrystalline cellulose and silica," International Journal of Photoenergy, ...
Benzo[a]pyrene (BaP). CASRN 50-32-8. *Toxicological Review (PDF) (234 pp, 4.67 M) ... Under EPAs Guidelines for Carcinogen Risk Assessment (U.S. EPA, 2005a), benzo[a]pyrene is "carcinogenic to humans" based on ... Sep 2016: IRIS Toxicological Review of Benzo[a]pyrene (Interagency Science Discussion Draft) (Report) ... Jun 2011: IRIS Toxicological Review of Benzo[a]pyrene (Interagency Science Consultation Draft) (Report) ...
Benzo[a]pyrene is a polynuclear aromatic hydrocarbon (PAH) and is found as the result of the combustion of organic matter such ... Benzo[a]pyrene is often the highest-risk contaminant at sites impacted by PAHs and historic fill materials such as ash, and ... While the Final Assessment concludes that benzo[a]pyrene is still a potent carcinogen, the revised parameters show that the ... Relief on the Way for Benzo[a]pyrene Cleanups? Manko Gold Katcher & Fox ...
... pyrene-induced Toxicity indicating that the following substances may be helpful: Curcumin, Quercetin, and Rutin ... Additional Keywords : Beet, Benzo(a)pyrene, Betaine, lung cancer, Vinyl Carbamate. Problem Substances : Benzo(a)pyrene, Vinyl ... Diseases : Benzo[a]pyrene-induced Toxicity , Lung Cancer. Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation, ... Diseases : Benzo[a]pyrene-induced Toxicity , Lung Cancer, Lung Damage. Pharmacological Actions : Anti-Inflammatory Agents, ...
... pyrene-7,8-dione , C20H10O2 , CID 105020 - structure, chemical names, physical and chemical properties, classification, patents ...
Pyrene and its derivatives are used commercially to make dyes and dye precursors, for example pyranine and naphthalene-1,4,5,8- ... Lateral diffusion in the hydrophobic region of membranes: use of pyrene excimers as optical probes.Biochimica et Biophysica ... Environmental effects on vibronic band intensities in pyrene monomer fluorescence and their application in studies of micellar ...
... pyrene testing. Laboratory testing for 3,4-Benzopyrene 50-32-8. 200-028-5 is yellow crystals or powder [found in cigarette ... Synonyms: Benz[a]pyrene;1,2-Benzpyrene;3,4-Benzopyrene;3,4-Benzpyrene;3,4-Benz[a]pyrene;6,7-Benzopyrene;Benzo[«alpha»]pyrene; ... Benzo(a)pyrene. ALS Environmental may or may not test for Benzo(a)pyrene (CAS # 50-32-8). Information is subject to change; ... Analyte: Benzo(a)pyrene. Alternate Name: 3,4-Benzopyrene. Abbreviation: BAP. CAS Number or ID: 50-32-8. Department: Organics. ...
... pyrene (CAAC-benzo[a]pyrene panel), will review this draft assessment. Details about the CAAC-Benzo[a]pyrene panel, meeting ... IRIS Toxicological Review of Benzo[a]pyrene (Public Comment Draft) * IRIS Toxicological Review of Benzo[a]pyrene (Interagency ... Benzo[a]pyrene is a five-ring polycyclic aromatic hydrocarbon that is relatively insoluble in water and has low volatility. It ... Benzo[a]pyrene (BaP). CASRN 50-32-8. *Toxicological Review (PDF) (234 pp, 4.67 M) ...
Benzo(a)pyrene - Toxicity. Toxicity. A vast number of studies over the previous three decades have documented links between ...
Benzo(a)pyrene. Synonyms: 3,4-Benz(a)pyrene. 3,4-Benzopyrene. 3,4-Benzpyrene. 6,7-Benzopyrene. Benzo(d,e,f)chrysene. B(a)P. BP ... Tumor-initiating activity and carcinogenicity of dibenzo(a,l)pyrene versus 7,12-dimethylbenz(a)anthracene and benzo(a)pyrene at ... Epidermal hyperplasia after topical application of benzo(a)pyrene, benzo(a)pyrene diol epoxides, and other metabolites. Cancer ... Comparative dose-response tumorigenicity studies of dibenzo(a,l)pyrene versus 7,12-dimethylbenz(a)anthracene, benzo(a)pyrene ...
Benzo(a)pyrene is present as a component of polycyclic aromatic hydrocarbons (PAHs) in the environment, usually resulting from ...
  • The correct title of this article is Benzo[ a ]pyrene . (wikipedia.org)
  • Benzo[ a ]pyrene is a polycyclic aromatic hydrocarbon and the result of incomplete combustion of organic matter at temperatures between 300 °C (572 °F) and 600 °C (1,112 °F). The ubiquitous compound can be found in coal tar, tobacco smoke and many foods, especially grilled meats. (wikipedia.org)
  • Benzo[ a ]pyrene (BaP) is a polycyclic aromatic hydrocarbon found in coal tar with the formula C 20 H 12 . (wikipedia.org)
  • Benzo[ a ]pyrene, showing the base pyrene ring and numbering and ring fusion locations according to IUPAC nomenclature of organic chemistry . (wikipedia.org)
  • However, 12.08 and14.68 ppb for Benzo(e)pyrene and 5.62 ppb for Indenol (1, 2, 3 - cd) pyrene exceeded the expected limit. (thefreedictionary.com)
  • Benzo(a)pyrene is present as a component of polycyclic aromatic hydrocarbons (PAHs) in the environment, usually resulting from the incomplete combustion or pyrolysis of organic matters, especially fossil fuels and tobacco. (inchem.org)
  • Benzo[a]pyrene is a polycyclic aromatic hydrocarbon, or PAH, released from combustion of fossil fuels and waste incinerators. (ewg.org)
  • The EWG Health Guideline of 0.007 ppb for benzo[a]pyrene was defined by the California Office of Environmental Health Hazard Assessment as a public health goal, the level of a drinking water contaminant that does not pose a significant health risk. (ewg.org)
  • The legal limit for benzo[a]pyrene, established in 1992, was based on analytical detection limits at the time that the standard was set. (ewg.org)
  • Until then, check out an example of dose-response assessment in Section 2 of the IRIS assessment of benzo[a]pyrene . (epa.gov)
  • Under EPA's Guidelines for Carcinogen Risk Assessment (U.S. EPA, 2005a), benzo[a]pyrene is "carcinogenic to humans" based on strong and consistent evidence in animals and humans. (epa.gov)
  • Relief on the Way for Benzo[a]pyrene Cleanups? (lexology.com)
  • Land developers and remediators in Pennsylvania and New Jersey may soon have an easier time addressing soils containing benzo[a]pyrene, one of the most ubiquitous urban contaminants, thanks to updated information that was just released by U.S. Environmental Protection Agency (EPA). (lexology.com)
  • The new information comes from EPA's Final Assessment of Benzo[a]pyrene , which was completed in January 2017 and is now part of EPA's Integrated Risk Information System (IRIS). (lexology.com)
  • While the Final Assessment concludes that benzo[a]pyrene is still a potent carcinogen, the revised parameters show that the chemical is not as toxicologically potent as was previously thought. (lexology.com)
  • Benzo[a]pyrene is a polynuclear aromatic hydrocarbon (PAH) and is found as the result of the combustion of organic matter such as wood, coal, oil, gasoline, diesel fuel, kerosene, and charcoal. (lexology.com)
  • Benzo[a]pyrene is often the highest-risk contaminant at sites impacted by PAHs and historic fill materials such as ash, and drives the remediation of soil that would otherwise be accepted as 'clean' for all other regulated substances. (lexology.com)
  • The revised toxicity criteria form the basis for the New Jersey Soil Remediation Standards and the Pennsylvania Statewide Health Standards, which define the acceptable default levels of benzo[a]pyrene that can be present in soil. (lexology.com)
  • 6-Gingerol abates benzo[a]pyrene-induced colonic injury. (greenmedinfo.com)
  • 6-gingerol delays tumorigenesis in benzo[a]pyrene and dextran sulphate sodium-induced colorectal cancer. (greenmedinfo.com)
  • 6-Gingerol protected against spermatotoxicity in experimental model of interaction of colitis with environmental pollutant benzo[a]pyrene. (greenmedinfo.com)
  • Anti-inflammatory and apoptotic signalling effect of fucoxanthin on benzo(A)pyrene-induced lung cancer. (greenmedinfo.com)
  • Antineoplaston A10 has a chempreventive effect on benzo(a)pyrene-induced pulmonary neoplasia. (greenmedinfo.com)
  • Assessment of the protective effects of selected dietary anticarcinogens against DNA damage and cytogenetic effects induced by benzo[a]pyrene. (greenmedinfo.com)
  • ALS Environmental may or may not test for Benzo(a)pyrene (CAS # 50-32-8). (caslab.com)
  • More analytical test methods may be available for Benzo(a)pyrene. (caslab.com)
  • The IRIS Toxicological Review of Benzo[a]pyrene was released for external peer review in September 2014. (epa.gov)
  • The EPA's Science Advisory Board's (SAB) Chemical Assessment Advisory Committee (CAAC) conducted a peer review of the scientific basis supporting the benzo[a]pyrene assessment and released a final report of their review in April 2016. (epa.gov)
  • Benzo[a]pyrene is a five-ring polycyclic aromatic hydrocarbon that is relatively insoluble in water and has low volatility. (epa.gov)
  • Natural sources of benzo[a]pyrene include forest fires and volcanoes, and anthropogenic sources include stoves/furnaces burning fossil fuels (especially wood and coal), motor vehicle exhaust, and various industrial combustion processes. (epa.gov)
  • In September 2014, EPA submitted the draft IRIS assessment of benzo[a]pyrene (see downloads) to the agency's Science Advisory Board (SAB) for peer review and comments. (epa.gov)
  • The SAB Chemical Assessment Advisory Committee (CAAC), augmented for the review of the draft IRIS assessment of benzo[a]pyrene (CAAC-benzo[a]pyrene panel), will review this draft assessment. (epa.gov)
  • Details about the CAAC-Benzo[a]pyrene panel, meeting dates, and times will be announced in a Federal Register Notice released by the SAB. (epa.gov)
  • Additional information on the SAB-CAAC review of benzo[a]pyrene is on the SAB website. (epa.gov)
  • EPA initiated the interagency science consultation on the draft Toxicological Review of Benzo[a]pyrene. (epa.gov)
  • A revised interagency science consultation draft Toxicological Review of Benzo[a]pyrene was provided for further review by other federal agencies and the Executive Office of the President. (epa.gov)
  • EPA announced a request for nominations for experts to augment the SAB CAAC committee for the upcoming review of the draft benzo[a]pyrene assessment. (epa.gov)
  • SAB released a list and biosketches of potential candidates to augment the SAB CAAC for the upcoming review of the draft benzo[a]pyrene assessment. (epa.gov)
  • EPA transmitted the external peer review draft benzo[a]pyrene assessment, including responses to major public comments, and the draft charge to the peer reviewers to the SAB. (epa.gov)
  • Benzo(a)pyrene (B(a)P) is not produced commercially and does not occur as a pure substance, except as a research chemical (99% purity). (intox.org)
  • Benzo(a)pyrene is widely distributed in the environment as a by-product of the incomplete combustion and thermal decomposition (pyrolysis) of fossil fuels and organic matter. (intox.org)
  • Pure benzo(a)pyrene (B(a)P) is a dust with an extremely low tendency to form a vapour. (intox.org)
  • Contact sensitization (an allergic skin reaction) has been reported in animals following short-term exposure to benzo(a)pyrene. (intox.org)
  • Fisetin modulates mitochondrial enzymes and apoptotic signals in benzo(a)pyrene-induced lung cancer. (nih.gov)
  • The present study was aimed to delineate in vivo mechanisms of orally administered fisetin with special reference to mitochondrial dysfunction in lung tissues employing benzo(a)pyrene (B(a)P) as the model lung carcinogen. (nih.gov)
  • Pulmonary microsomal metabolism of benzo(a)pyrene following exposure of rats to silica. (cdc.gov)
  • The effects of administering silica (14808607) to rats on the pulmonary microsomal metabolism of benzo(a)pyrene (50328) (BP) was examined. (cdc.gov)
  • The distribution of radioactive material within maternal and embryonic/fetal mouse tissue was studied over a period of 2 days following a single dose of 14C-benzo(a)pyrene (B(a)P) orally on days 11, 12, 13 or 18 of pregnancy. (nih.gov)
  • Effect of eugenol on the mutagenicity of benzo[a]pyrene and the formation of benzo[a]pyrene-DNA adducts in the X-lacZ-transgenic mouse. (tudelft.nl)
  • Overexpression of Catalase Enhances Benzo(a)pyrene Detoxification in Endothelial Microsomes. (sigmaaldrich.com)
  • We previously reported that overexpression of catalase upregulated xenobiotic- metabolizing enzyme (XME) expression and diminished benzo(a)pyrene (BaP) intermediate accumulation in mouse aortic endothelial cells (MAECs). (sigmaaldrich.com)
  • Activity of rat UGT1A1 towards benzo[a]pyrene phenols and dihydrodiols. (biomedsearch.com)
  • Four UDP-glucuronosyltransferases from the rat UGT1A family were tested for activity towards benzo[a]pyrene phenols and dihydrodiols. (biomedsearch.com)
  • Antisera recognizing rat UGT1A1 and UGT1A7 were used to assess UGT levels in relation to UGT activity towards benzo[a]pyrene-7,8-dihydrodiol (BPD). (biomedsearch.com)
  • A global-scale three dimensional atmospheric transport and chemistry model was applied to simulate transpacific transport of Benzo[a]pyrene (BaP) emitted from Asia. (oregonstate.edu)
  • We used an approach of global optimization of the parametersdescribing the diffusion and reaction of the ultimate carcinogenic PAHmetabolite benzo[a]pyrene diol epoxide to fit measured values from the fourV79 cell lines. (diva-portal.org)
  • We developed a food frequency questionnaire with detailed questions on meat-cooking methods and doneness levels and a benzo[ a ]pyrene (BaP) database (as a surrogate for total carcinogenic PAHs) based on the collection and analysis of a wide range of food samples. (aacrjournals.org)
  • Animal studies have shown that dietary intake of benzo(a)pyrene (BaP), a PAH, causes increased levels of tumors at several sites, particularly in the gastrointestinal tract ( 11 ). (aacrjournals.org)
  • The objective of this study was to evaluate the reproductive risk associated with exposure of adult male Fisher-344 (F-344) rats to inhaled benzo(a)pyrene (BaP), a ubiquitous environmental toxicant present in cigarette smoke, automobile exhaust fumes and industrial emissions. (mdpi.com)
  • We review studies which investigate the presence, using structure-specific analytical methods, of DNA or protein adducts of the carcinogen benzo[a]pyrene (BaP) in human tissues. (nih.gov)
  • beta-Glucuronidase catalyzes the hydrolysis of benzo[a]pyrene-3-glucuronide to 3-hydroxybenzo[a]pyrene. (sciencemag.org)
  • During the enzymatic hydrolysis, a benzo[a]pyrene derivative is formed which binds to DNA to a far greater extent than either the 3-hydroxybenzo[a]pyrene or its glucuronide. (sciencemag.org)
  • These results suggest that conjugates of benzo(a)pyrene may be converted by beta-glucuronidase at intracellular and organ sites distal to the initial sites of oxygenation and conjugation of benzo(a)pyrene to activated intermediates that are possibly carcinogenic. (sciencemag.org)
  • In complementary experiments, sulforaphane blocked benzo[ a ]pyrene-evoked forestomach tumors in ICR mice. (pnas.org)
  • S. J. Weeks, S. M. Gilles, and A. P. D'Silva, "Detection of Benzo[a]pyrene Metabolites by Laser-Excited Shpol'skii Spectrometry," Appl. (osapublishing.org)
  • The infamous carcinogen benzo[a]pyrene (B[a]P) and its metabolites are often used as marker compounds to assess human exposure to total PACs and to study the development of cancer. (osapublishing.org)
  • Effect of dihydromyricetin on benzo[a]pyrene activation in rats. (nel.edu)
  • Since this flavonoid is being considered for human use, the in vivo study of DHM interactions with the cytochrome P450 (CYP) multienzyme system in the respect of metabolic activation of a model food-born carcinogen, benzo[a]pyrene (BaP), is of high importance. (nel.edu)
  • For evaluation of the capacity for metabolism of these carcinogens in this target tissue, the conversion of the carcinogen benzo( a )pyrene (BP) to polar products was studied in tracheal organ cultures and in isolated tracheal microsomes. (aacrjournals.org)
  • Benzo( a )pyrene is considered a classic DNA-damaging carcinogen and is one of a multitude of polycyclic aromatic hydrocarbons commonly found in tobacco smoke and in the ambient environment. (aacrjournals.org)
  • In this report, we describe the characteristics of chromosomal aberrations induced in vitro by activated benzo( a )pyrene diol epoxide (BPDE) in lymphocyte cultures of 172 normal individuals ages 19-95 years and present the analysis of a pilot case-control study of 33 lung cancer patients and 96 selected controls without history of cancer and frequency matched on age (50-85 years) to the cases. (aacrjournals.org)
  • Foreskins from children who were circumcised 2 to 4 days after birth contain an enzyme system that hydroxylates the carcinogen benzo[α]pyrene. (sciencemag.org)
  • When foreskin was cultured for 16 hours in the presence of 10 micromolar benz[α]anthracene, a two- to fivefold increase in activity of benzo[α]pyrene hydroxylase was obtained. (sciencemag.org)
  • Benzo(a)pyrene is part of a class of chemicals called polycyclic aromatic hydrocarbons (PAH). (burningissues.org)
  • Benzo(a)pyrene is on the priority pollutant list published by the U.S. Environmental Protection Agency (EPA). (burningissues.org)
  • Where can benzo(a)pyrene be found and how is it used? (burningissues.org)
  • Benzo(a)pyrene is found in nature from the eruption of volcanoes and forest fires. (burningissues.org)
  • Man-made releases of benzo(a)pyrene are to the air, where sunlight turns the chemical into a dry form that falls to the ground and breaks down in the soil. (burningissues.org)
  • The major indoor sources of benzo(a)pyrene in the air are wood-burning fireplaces and stoves, and tobacco smoking. (burningissues.org)
  • There is no known industry production or use of benzo(a)pyrene. (burningissues.org)
  • How can people be exposed to benzo(a)pyrene? (burningissues.org)
  • Breathing air containing benzo(a)pyrene in the workplace. (burningissues.org)
  • You can also breathe benzo(a)pyrene from cigarette smoke, wood smoke, vehicle exhaust, asphalt roads or smoke from burning farm plants. (burningissues.org)
  • Contact with benzo(a)pyrene in the air, water, or soil near a waste site, or another polluted site. (burningissues.org)
  • Nursing infants may be exposed through breast milk, especially if the mother lives near a waste site containing benzo(a)pyrene. (burningissues.org)
  • How does benzo(a)pyrene work and how can it affect my health? (burningissues.org)
  • Benzo[a]pyrene is a probable cancer-causing agent in humans. (burningissues.org)
  • If benzo(a)pyrene is on your skin when you are being exposed to sunlight or ultraviolet light, the risk of skin cancer is greater. (burningissues.org)
  • Repeated exposure to substances containing benzo[a]pyrene may cause the skin to thicken and darken, and for pimples to appear. (burningissues.org)
  • Bronchitis may result from repeated exposure to mixtures containing benzo(a)pyrene. (burningissues.org)
  • How is benzo(a)pyrene poisoning treated? (burningissues.org)
  • There is no treatment for benzo(a)pyrene. (burningissues.org)
  • What should I do if exposed to benzo(a)pyrene? (burningissues.org)
  • Anyone who may have been exposed to high levels of benzo(a)pyrene should be removed from the source of exposure immediately. (burningissues.org)
  • Clothing in contact with benzo(a)pyrene should be removed and discarded. (burningissues.org)
  • Skin and eyes exposed to benzo(a)pyrene should be flushed with clean water for at least 15 minutes. (burningissues.org)
  • What factors limit use or exposure to benzo(a)pyrene? (burningissues.org)
  • Workers should use benzo(a)pyrene in a regulated, enclosed area with local exhaust ventilation. (burningissues.org)
  • The area should be marked as a site where benzo(a)pyrene is handled, used, stored or formed. (burningissues.org)
  • Is there a medical test to show whether I've been exposed to benzo(a)pyrene? (burningissues.org)
  • For references , please go to https://www.eea.europa.eu/data-and-maps/figures/concentration-of-benzo-a-pyrene-bap-in-the-upper-soil-in-kindergartens-in-the-czech-cities-monitored-in-2004 or scan the QR code. (europa.eu)
  • NOEs between benzo[a]pyrene and DNA protons were localized on the two faces of the pyrenyl ring. (rcsb.org)
  • G18 N1H showed NOEs to both faces of benzo[a]pyrene. (rcsb.org)
  • 1 ppm for T17 H6 and CH3, and 0.75 ppm for C5 H5, with a smaller shift for C5 H6, and a 1.5 ppm dispersion of the pyrenyl protons suggested that benzo[a]pyrene intercalated above the 5'-face of S.R.S.R A6. (rcsb.org)
  • The rise between C5.G18 and S.R.S.R A6.T17 was calculated to be 7 A. The work extended the pattern for adenine N6 benzo[a]pyrene adducts, in which the R stereochemistry at C10 predicted 5'-intercalation of the pyrenyl moiety. (rcsb.org)
  • Lin, T. and Yang, M.S. (2007) Benzo [a] pyrene-induced elevation of GSH level protects against oxidative stress and enhances xenobiotic detoxification in human HepG2 cells. (scirp.org)
  • The present study has been undertaken to examine whether exposure to benzo(a)pyrene (BaP), a polycyclic aromatic hydrocarbon (PAH) compound influences the metabolism of fluoranthene (FLA), another PAH compound. (pubmedcentralcanada.ca)
  • To determine the effectiveness of these two exposure scenarios, we studied the in vitro metabolism of two PAH compounds benzo(a)pyrene (BaP) and fluoranthene (FLA) using microsomes. (pubmedcentralcanada.ca)
  • Transformation rates of naphthalene, phenanthrene, and benzo[ a ]pyrene in oxidized surficial sediments of a polluted urban estuary, Boston Harbor, Mass., were determined over a period of 15 months. (asm.org)
  • phenanthrene, 7.9 to 19.8 days, and benzo[ a ]pyrene, 53.7 to 82.3 days. (asm.org)
  • Antibodies generated against benzo(a)pyrene diol epoxide modified DNA were used to investigate adducts in skin biopsies of coal tar treated psoriasis patients. (eurekamag.com)
  • Recently, fast-growing Mycobacteria have been identified that can degrade HMW PAHs, such as pyrene and benzo[a]pyrene. (tennessee.edu)
  • Previous studies showed that dietary calcium D-glucarate (CG) inhibited benzo[a]pyrene (B[a]P)-induced A/J mouse lung tumorigenesis, suppressing cell proliferation and chronic inflammation and inducing apoptosis during late post-initiation stages. (spandidos-publications.com)
  • The objective of this study was to determine whether sediment ingestion or water ventilation was the primary route of uptake for benzo[ a ]pyrene (B a P) in the gizzard shad ( Dorosoma cepedianum ), a detritivorous fish. (usgs.gov)
  • The litter-decomposing basidiomycete Stropharia coronilla , which preferably colonizes grasslands, was found to be capable of metabolizing and mineralizing benzo[ a ]pyrene (BaP) in liquid culture. (asm.org)
  • 19 different PAHs (including benzo(a)pyrene, pyrene, and phenanthrene) were measured at the workplace by personal air monitoring. (ebscohost.com)
  • Concentrations of phenanthrene, pyrene, and benzo(a)pyrene in air correlated well with the concentration of total PAHs in air;they could be used for comparisons of different workplaces if the emission compositions were known. (ebscohost.com)
  • In this study effect of residential wood combustion on the benzo[ a ]pyrene concentrations in the air of Helsinki metropolitan area was studied, using ambient air measurements, emission estimates and dispersion modeling. (atmos-chem-phys.net)
  • With the use of synthetic and biologically produced metabolites, seven of nine peaks are tentatively assigned to one or more metabolites of benzo[ a ]pyrene. (aspetjournals.org)
  • Peaks B, D, F, and I include products of benzo[ a ]pyrene quinones that are further metabolized. (aspetjournals.org)
  • Peak E reflects almost exclusively both the cis - and trans -7,8-diol 9,10-epoxides of benzo[ a ]pyrene. (aspetjournals.org)
  • Peak H comprises reactive intermediates resulting from the further metabolism of benzo[ a ]pyrene phenols. (aspetjournals.org)
  • The 7,8-oxide and the 9,10-oxide contribute to peaks E, F, G, and H. Benzo[ a ] pyrene thus may be metabolized to four different "types" of reactive intermediates capable of binding to DNA: (a) primary arene oxides, (b) diol epoxides, (c) phenols oxygenated further, and (d) quinones oxygenated further (or quinone-derived free radicals). (aspetjournals.org)
  • Benzo(a)pyrene inhibits epidermal growth factor binding and receptor autophosphorylation in human placental cell cultures. (aspetjournals.org)
  • Studies investigated the effects of benzo(a)pyrene (BP) treatment on epidermal growth factor (EGF) receptor binding and kinase activity in human placental cell cultures. (aspetjournals.org)
  • Antioxidant vitamin supplementation reduces benzo(a)pyrene-DNA adducts and potential cancer risk in female smokers. (ccceh.org)
  • Background: Elevated benzo(a)pyrene [B(a)P]-DNA adducts have been associated with 3-fold increased risk of lung cancer in current smokers. (ccceh.org)
  • To improve understanding of the soil-dermal exposure pathway, in vitro assessments of radiolabeled benzo[a]pyrene (BaP) absorption through human epidermis were conducted. (washington.edu)
  • In May 2017 the CORESTA Tobacco and Tobacco Products Analytes Sub-Group (TTPA SG) initiated a collaborative study for the determination of ammonia and benzo[a]pyrene in smokeless tobacco, cigarette filler, and ground cigars (wrapper, binder, and filler). (coresta.org)
  • In this study, a new complementary DNA (cDNA) of the CYP1B subfamily encoding 1B1 was isolated from Nile tilapia ( Oreochromis niloticus ) liver after intracoelomic injection with benzo (a) pyrene (BaP). (ajol.info)
  • Benzo (a) pyrene-albumin adducts in humans exposed to polycyclic aromatic hydrocarbons in an industrial area of Poland. (ehesp.fr)
  • Objectives-The interaction of benzo (a) pyrene with serum albumin was measured in an attempt to identify the actual exposure and to evaluate albumin adduct measurements as biomarkers for exposure monitoring. (ehesp.fr)
  • Methods-Benzo (a) pyrene-diolepoxide (BPDE) - albumin adducts were measured by competitive enzyme linked immunosorbent assay (ELISA) in plasma of coke oven plant workers from three plants and from people living in a highly industrialised area of Silesia in Poland. (ehesp.fr)
  • The possible interactions of high dietary levels of fat (HF) or fat + cholesterol (HC) with the lipid-soluble carcinogen benzo(a)pyrene (BP) have been investigated in the male guinea pig. (soton.ac.uk)
  • G6PD deficiency protects in vitro growing HSF and lymphocytes from benzo(a)pyrene (BaP) toxicity. (springer.com)
  • F. Feo, L. Pirisi, R. Pascale, L. Daino, S. Frassetto and R. Garcea, Modulatory effect of glucose-6-phosphate dehydrogenase deficiency on the benzo(a)pyrene toxicity and transforming activity for in vitro cultured human skin fibroblasts, Cancer Res. (springer.com)
  • F. Feo, L. Pirisi, R. Pascale, L. Daino, S. Frassetto, S. Zanetti and R. Garcea, Modulatory mechanisms of chemical carcinogenesis: the role of the NADPH pool in benzo(a)pyrene activation, Toxicol. (springer.com)
  • L. Pirisi, R. Garcea, R. Pascale, M. E. Ruggiu and F. Feo, Control of glucose-6-phosphate dehydrogenase deficiency on the formation of mutagenic and carcinogenic metabolites derived from benzo(a)pyrene, Toxicol. (springer.com)
  • K. Rudo, S. Ellis, B. J. Bryant, K. Lawrence, G. Curtis, H. Garland and S. Nesnow, Quantitative analysis of the metabolism of benzo(a)pyrene by transformable C3H10T1/2CL8 mouse embryo fibroblasts, Teratog. (springer.com)
  • L. A. Reinke, P. McManus, F. C. Kauffman and R. G. Thurman, Benzo(a)-pyrene phenol production by perfused rat liver and its inhibition by ethanol, Cancer Res. (springer.com)
  • I. J. Sadowski, J. A. Wright and L. G. Israels, A permeabilized cell system for studying regulation of aryl hydrocarbon hydroxylase: NADPH as rate limiting factor in benzo(a)pyrene metabolism, Int. J. Biochem. (springer.com)
  • Preliminary Bibliography for Dibenzo(a,e)pyrene. (cdc.gov)
  • This preliminary bibliography on dibenzo(a,e)pyrene (192654) was prepared for the NIOSH criteria documentation program. (cdc.gov)
  • Dibenzo[a,l]pyrene (DBP), an extremely potent environmental carcinogen, has been isolated from urban air samples, tobacco smoke, and coal smoke condensate. (oregonstate.edu)
  • Most studies reviewed here measured tetraols released from DNA or protein by hydrolysis of adducts derived from (7R,8S)-dihydroxy-(9S,10R)-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene (BPDE), a major ultimate carcinogen of BaP. (nih.gov)
  • Pyrene is a polycyclic aromatic hydrocarbon (PAH) consisting of four fused benzene rings, resulting in a flat aromatic system. (wikipedia.org)
  • DeBruyn, Jennifer M., "Distribution and dynamics of pyrene-degrading Mycobacteria in freshwater sediments contaminated with polycyclic aromatic hydrocarbons. (tennessee.edu)
  • To investigate the specificity of biological monitoring variables (excretion of phenanthrene and pyrene metabolites in urine) and the usefulness of some biomarkers of effect (alkaline filter elution, {sup}32{end}P postlabeling assay, measurement of sister chromatid exchange)in workers exposed to polycyclic aromatic hydrocarbons (PAHs). (ebscohost.com)
  • Phenanthrene and pyrene metabolites were purified by high-performance liquid chromatography and identified by UV absorption, mass, and 1H nuclear magnetic resonance spectrometry. (nih.gov)
  • Fungi capable of mineralizing phenanthrene and pyrene in liquid culture produced enriched metabolites substituted in the K region (C-9,10 position of phenanthrene and C-4,5 position of pyrene), whereas all other fungi investigated produced metabolites substituted in the C-1,2, C-3,4, and C-9,10 positions of phenanthrene and the C-1 position of pyrene. (nih.gov)
  • After 24 hr the metabolites formed in tracheal organ cultures largely cochromatographed with tetrols, triols, and the trans -9,10-dihydro-9-10-dihydroxybenzo( a )pyrene of BP. (aacrjournals.org)
  • Phenanthrene and pyrene metabolites were measured in 24 hour urine samples. (ebscohost.com)
  • Pyrene forms during incomplete combustion of organic compounds. (wikipedia.org)
  • The highest mineralization of [14C] pyrene was detected in straw cultures of T. versicolor (34.1%), which suggested that mineralization of both compounds by fungi may be independent of the number of aromatic rings. (nih.gov)
  • A new class of dual fluorescent chemosensors for nitroaromatic compounds (NACs) based on phosphonated pyrene derivatives is reported, showing high selectivity towards trinitrotoluene (TNT). (rsc.org)
  • This compound belongs to the class of organic compounds known as pyrenes. (drugbank.ca)
  • These are compounds containing a pyrene moiety, which consists four fused benzene rings, resulting in a flat aromatic system. (drugbank.ca)
  • Pyrene used as a model PAH due to its specific volatility and miscibility characteristics, relatively soluble yet hydrophobic to explore the potential of sepiolite (Turkish origin) to sorb hydrophobic organic compounds from aqueous solution. (surrey.ac.uk)
  • However, its intracrystalline interactions with pyrene were more favorable than the surface Si-OH groups which could react directly with pyrene to form compounds with true covalent bonds (chemical interactions) between sepiolite and pyrene. (surrey.ac.uk)
  • Comparison of phenanthrene and pyrene degradation by different wood-decaying fungi. (nih.gov)
  • The degradation of phenanthrene and pyrene was investigated by using five different wood-decaying fungi. (nih.gov)
  • In recent years, pyrene‐based porous materials have been widely used in various fields, such as photo‐catalysis, photoelectric devices, chemical sensing, gas storage and separation, and degradation of nerve agent simulants due to their excellent rigidity and photophysical properties. (pubmedcentralcanada.ca)
  • Influence of contact time on extractability and degradation of pyrene in sons. (lancs.ac.uk)
  • A. S. Oliveira, L. F. Vieira Ferreira, J. P. Da Silva, and J. C. Moreira, "Surface photochemistry: Photodegradation study of pyrene adsorbed onto microcrystalline cellulose and silica," International Journal of Photoenergy , vol. 6, no. 4, pp. 205-213, 2004. (hindawi.com)
  • The document reports on such a study of pyrene and in addition, compares the pressure-enhanced electronic relaxation for the monomeric and excimeric forms of pyrene. (dtic.mil)
  • The ratios of excretion to intake via dermal absorption for fluorene, phenanthrene, and pyrene were lower than the ratios from dietary exposure but higher than the ratios from inhalation. (thefreedictionary.com)
  • These PAHs are naphthalene, fluorene, phenanthrene, and pyrene , all present in high concentrations in the complex Superfund-derived PAH mixture. (thefreedictionary.com)
  • This work demonstrates the prevalence of pyrene-degrading organisms in contaminated sediments and implicates an integral role in natural attenuation of HMW PAHs. (tennessee.edu)
  • Here, we report the covalent functionalization of multiwalled carbon nanotubes (MWCNTs) with pyrene via Cu(i)-catalysed azide/alkyne click (CuAAC) reactions under mild conditions to afford the nanocomposites of pyrene-MWCNTs. (biomedsearch.com)
  • N-(1-Pyrene)maleimide is highly fluorescent upon covalent binding with sulfhydryl and amino groups of the proteins. (spie.org)
  • This review exposes the current poor understanding of the internal segmental chain dynamics of dendrimers in solution probed by monitoring the process of excimer formation between pyrene labels covalently attached to the chain ends of dendrimers. (mdpi.com)
  • The review begins by covering the bases of fluorescence and the kinetics of pyrene excimer formation before describing a procedure based on the Model Free (MF) analysis that is used to analyze quantitatively the fluorescence decays acquired for dendrimers, the ends of which have been fully and covalently labeled with pyrene. (mdpi.com)
  • Comparison of the various trends obtained by different research groups describing the efficiency of pyrene excimer formation with the generation number of dendrimers illustrates the lack of consensus between the few studies devoted to the topic. (mdpi.com)
  • One possible reason for this disagreement might reside in the presence of minute amounts of unattached pyrene labels which act as potent fluorescent impurities and affect the analysis of the fluorescence spectra and decays in an uncontrolled manner. (mdpi.com)
  • Fluorescent probe for Fe(iii) based on pyrene grafted multiwalled carbon nanotubes by click reaction. (biomedsearch.com)
  • The fluorescent signal of monomer pyrene actin is enhanced during its polymerization into filaments, making it an ideal tool for monitoring actin filament formation. (cytoskeleton.com)
  • Stringent quality control ensures that AP05 pyrene F-actin has a 7-12 fold fluorescent enhancement over non-polymerized pyrene G-actin (See Fig 2). (cytoskeleton.com)
  • Polymerized pyrene F-actin shows a 10 fold fluorescent enhancement over non-polymerized pyrene G-actin and buffer control. (cytoskeleton.com)
  • A pyrene-functionalized polymer was patterned via electron beam lithography onto a silicon wafer and shown to selectively bind with carbon nanotubes . (rsc.org)
  • 0.5 can be used as a measure of the dimension of the macromolecular object onto which the pyrene labels are covalently attached. (uwaterloo.ca)
  • The review points out that the MF analysis of the fluorescence decays acquired with pyrene-labeled dendrimers enables one to account for the presence of unattached pyrene and to retrieve information about the internal segmental dynamics of the dendrimer. (mdpi.com)
  • The substance with the formula C 20 H 12 is one of the benzopyrenes , formed by a benzene ring fused to pyrene . (wikipedia.org)
  • An N-(1-pyrene) iodoacetamide is used to label the actin protein. (cytoskeleton.com)
  • Pyrene labeling stoichiometry has been determined to be 0.6 dyes per actin monomer. (cytoskeleton.com)
  • Pyrene labeled rabbit muscle actin has an approximate molecular weight of 43 kDa, and is supplied as a white lyophilized powder. (cytoskeleton.com)
  • Pyrene Muscle Actin Protein Purity Determination. (cytoskeleton.com)
  • A 100 µg sample of pyrene muscle actin (molecular weight approx. (cytoskeleton.com)
  • Fluorescence enhancement during pyrene actin polymerization. (cytoskeleton.com)
  • Pyrene muscle actin was polymerized in duplicate wells of a 96-well plate by the addition of Actin Polymerization Buffer (Cat. (cytoskeleton.com)
  • Pressure-relaxation studies of pyrene-labelled actin and myosin subfragment 1 from rabbit skeletal muscle. (biochemj.org)
  • Its derivatives are also valuable molecular probes via fluorescence spectroscopy, having a high quantum yield and lifetime (0.65 and 410 nanoseconds, respectively, in ethanol at 293 K). Pyrene was the first molecule for which excimer behavior was discovered. (wikipedia.org)
  • Cyclopenta[c,d]pyrene (CAS 27208-37-3) Market Research Report 2017 contents were worked out and placed on the website in December, 2017. (marketpublishers.com)
  • Please note that Cyclopenta[c,d]pyrene (CAS 27208-37-3) Market Research Report 2017 is a half ready publication and contents are subject to change. (marketpublishers.com)
  • Fourier transform infrared spectroscopy (FT-IR), ultraviolet and visible spectroscopy (UV-Vis), and fluorescence spectroscopy were used to characterize the nanocomposites of pyrene clicked MWCNTs. (biomedsearch.com)
  • Pyrene and its derivatives are used commercially to make dyes and dye precursors, for example pyranine and naphthalene-1,4,5,8-tetracarboxylic acid. (wikipedia.org)
  • Environmental effects on vibronic band intensities in pyrene monomer fluorescence and their application in studies of micellar systems. (alfa.com)
  • The work established the magnitude of environmental influences on the singlet lifetime of pyrene and demonstrated a remarkable insensitivity of the emitting species to the nature of the microscopic surroundings, be it monomer or excimer. (dtic.mil)
  • Eight pyrene labeled dendrons (PyLDs) were prepared with a polyester backbone of bis(hydroxymethyl)propionic acid and the monomer and excimer fluorescence decays of the PyLDs were acquired and fitted according to the recently introduced model free analysis (MFA). (uwaterloo.ca)
  • Pyrene punctata, common name : the telescoped dove shell, is a species of sea snail, a marine gastropod mollusk in the family Columbellidae, the dove snails. (wikipedia.org)
  • Experiments in pigs show that urinary 1-hydroxypyrene is a metabolite of pyrene, when given orally. (wikipedia.org)
  • As a peri-fused PAH, pyrene is much more resonance-stabilized than its five-member-ring containing isomer fluoranthene. (wikipedia.org)
  • The nonsterile pasture soil was the only incubation to show significant loss of [C-14]pyrene-associated activity over the 24-week incubation. (lancs.ac.uk)
  • Significant nonextractable residues were formed with increased soil-pyrene contact time in all soils, with the largest increase found in the nonsterile pasture soil. (lancs.ac.uk)
  • After 24-week soil-pyrene contact time, the bioavailability of the added [C-14]pyrene was assessed by bacterial mineralization. (lancs.ac.uk)
  • Pyrene-carbon-tetrachloride complexes have been observed when polar and non-polar solvents have been used. (osu.edu)
  • In this study, temporal changes in extractability of [C-14]pyrene were followed in two soils with differing organic matter contents under sterile and nonsterile conditions over 24 weeks. (lancs.ac.uk)
  • Winkelmann J. (2018) Diffusion coefficient of pyrene in octane at infinite dilution. (springer.com)
  • The results of these studies indicate the pyrene-degrading Mycobacteria have broad, cosmopolitan distribution in contaminated sediments and suspended particles. (tennessee.edu)
  • It provides guidelines that should enable future studies on pyrene-labeled dendrimers to yield results that are more straightforward to interpret. (mdpi.com)
  • The compound is one of the benzopyrenes , formed by a benzene ring fused to pyrene , and is the result of incomplete combustion at temperatures between 300 °C (572 °F) and 600 °C (1,112 °F). (wikipedia.org)
  • Pyrene was first isolated from coal tar, where it occurs up to 2% by weight. (wikipedia.org)