Helicobacter pylori: A spiral bacterium active as a human gastric pathogen. It is a gram-negative, urease-positive, curved or slightly spiral organism initially isolated in 1982 from patients with lesions of gastritis or peptic ulcers in Western Australia. Helicobacter pylori was originally classified in the genus CAMPYLOBACTER, but RNA sequencing, cellular fatty acid profiles, growth patterns, and other taxonomic characteristics indicate that the micro-organism should be included in the genus HELICOBACTER. It has been officially transferred to Helicobacter gen. nov. (see Int J Syst Bacteriol 1989 Oct;39(4):297-405).Helicobacter Infections: Infections with organisms of the genus HELICOBACTER, particularly, in humans, HELICOBACTER PYLORI. The clinical manifestations are focused in the stomach, usually the gastric mucosa and antrum, and the upper duodenum. This infection plays a major role in the pathogenesis of type B gastritis and peptic ulcer disease.Amoxicillin: A broad-spectrum semisynthetic antibiotic similar to AMPICILLIN except that its resistance to gastric acid permits higher serum levels with oral administration.Clarithromycin: A semisynthetic macrolide antibiotic derived from ERYTHROMYCIN that is active against a variety of microorganisms. It can inhibit PROTEIN SYNTHESIS in BACTERIA by reversibly binding to the 50S ribosomal subunits. This inhibits the translocation of aminoacyl transfer-RNA and prevents peptide chain elongation.Omeprazole: A 4-methoxy-3,5-dimethylpyridyl, 5-methoxybenzimidazole derivative of timoprazole that is used in the therapy of STOMACH ULCERS and ZOLLINGER-ELLISON SYNDROME. The drug inhibits an H(+)-K(+)-EXCHANGING ATPASE which is found in GASTRIC PARIETAL CELLS.Anti-Ulcer Agents: Various agents with different action mechanisms used to treat or ameliorate PEPTIC ULCER or irritation of the gastrointestinal tract. This has included ANTIBIOTICS to treat HELICOBACTER INFECTIONS; HISTAMINE H2 ANTAGONISTS to reduce GASTRIC ACID secretion; and ANTACIDS for symptomatic relief.Bismuth: A metallic element that has the atomic symbol Bi, atomic number 83 and atomic weight 208.98.Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS. It has also been proposed as a radiation sensitizer for hypoxic cells. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985, p133), this substance may reasonably be anticipated to be a carcinogen (Merck, 11th ed).2-Pyridinylmethylsulfinylbenzimidazoles: Compounds that contain benzimidazole joined to a 2-methylpyridine via a sulfoxide linkage. Several of the compounds in this class are ANTI-ULCER AGENTS that act by inhibiting the POTASSIUM HYDROGEN ATPASE found in the PROTON PUMP of GASTRIC PARIETAL CELLS.Tinidazole: A nitroimidazole antitrichomonal agent effective against Trichomonas vaginalis, Entamoeba histolytica, and Giardia lamblia infections.Lansoprazole: A 2,2,2-trifluoroethoxypyridyl derivative of timoprazole that is used in the therapy of STOMACH ULCERS and ZOLLINGER-ELLISON SYNDROME. The drug inhibits H(+)-K(+)-EXCHANGING ATPASE which is found in GASTRIC PARIETAL CELLS. Lansoprazole is a racemic mixture of (R)- and (S)-isomers.Drug Therapy, Combination: Therapy with two or more separate preparations given for a combined effect.Duodenal Ulcer: A PEPTIC ULCER located in the DUODENUM.Dyspepsia: Impaired digestion, especially after eating.Anti-Bacterial Agents: Substances that reduce the growth or reproduction of BACTERIA.Proton Pump Inhibitors: Compounds that inhibit H(+)-K(+)-EXCHANGING ATPASE. They are used as ANTI-ULCER AGENTS and sometimes in place of HISTAMINE H2 ANTAGONISTS for GASTROESOPHAGEAL REFLUX.Peptic Ulcer: Ulcer that occurs in the regions of the GASTROINTESTINAL TRACT which come into contact with GASTRIC JUICE containing PEPSIN and GASTRIC ACID. It occurs when there are defects in the MUCOSA barrier. The common forms of peptic ulcers are associated with HELICOBACTER PYLORI and the consumption of nonsteroidal anti-inflammatory drugs (NSAIDS).Ranitidine: A non-imidazole blocker of those histamine receptors that mediate gastric secretion (H2 receptors). It is used to treat gastrointestinal ulcers.Gastritis: Inflammation of the GASTRIC MUCOSA, a lesion observed in a number of unrelated disorders.Furazolidone: A nitrofuran derivative with antiprotozoal and antibacterial activity. Furazolidone acts by gradual inhibition of monoamine oxidase. (From Martindale, The Extra Pharmacopoeia, 30th ed, p514)Gastric Mucosa: Lining of the STOMACH, consisting of an inner EPITHELIUM, a middle LAMINA PROPRIA, and an outer MUSCULARIS MUCOSAE. The surface cells produce MUCUS that protects the stomach from attack by digestive acid and enzymes. When the epithelium invaginates into the LAMINA PROPRIA at various region of the stomach (CARDIA; GASTRIC FUNDUS; and PYLORUS), different tubular gastric glands are formed. These glands consist of cells that secrete mucus, enzymes, HYDROCHLORIC ACID, or hormones.Antacids: Substances that counteract or neutralize acidity of the GASTROINTESTINAL TRACT.Breath Tests: Any tests done on exhaled air.Rabeprazole: A 4-(3-methoxypropoxy)-3-methylpyridinyl derivative of timoprazole that is used in the therapy of STOMACH ULCERS and ZOLLINGER-ELLISON SYNDROME. The drug inhibits H(+)-K(+)-EXCHANGING ATPASE which is found in GASTRIC PARIETAL CELLS.Antitrichomonal Agents: Agents used to treat trichomonas infections.Disease Eradication: Termination of all transmission of infection by global extermination of the infectious agent through surveillance and containment (From Porta, A Dictionary of Epidemiology, 5th ed).Sulfoxides: Organic compounds that have the general formula R-SO-R. They are obtained by oxidation of mercaptans (analogous to the ketones). (From Hackh's Chemical Dictionary, 4th ed)Penicillins: A group of antibiotics that contain 6-aminopenicillanic acid with a side chain attached to the 6-amino group. The penicillin nucleus is the chief structural requirement for biological activity. The side-chain structure determines many of the antibacterial and pharmacological characteristics. (Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed, p1065)Stomach Neoplasms: Tumors or cancer of the STOMACH.Gastroscopy: Endoscopic examination, therapy or surgery of the interior of the stomach.Lymphoma, B-Cell, Marginal Zone: Extranodal lymphoma of lymphoid tissue associated with mucosa that is in contact with exogenous antigens. Many of the sites of these lymphomas, such as the stomach, salivary gland, and thyroid, are normally devoid of lymphoid tissue. They acquire mucosa-associated lymphoid tissue (MALT) type as a result of an immunologically mediated disorder.Stomach Ulcer: Ulceration of the GASTRIC MUCOSA due to contact with GASTRIC JUICE. It is often associated with HELICOBACTER PYLORI infection or consumption of nonsteroidal anti-inflammatory drugs (NSAIDS).Tetracycline: A naphthacene antibiotic that inhibits AMINO ACYL TRNA binding during protein synthesis.Gastritis, Atrophic: GASTRITIS with atrophy of the GASTRIC MUCOSA, the GASTRIC PARIETAL CELLS, and the mucosal glands leading to ACHLORHYDRIA. Atrophic gastritis usually progresses from chronic gastritis.Metaplasia: A condition in which there is a change of one adult cell type to another similar adult cell type.Urease: An enzyme that catalyzes the conversion of urea and water to carbon dioxide and ammonia. EC 18.104.22.168.Histamine H2 Antagonists: Drugs that selectively bind to but do not activate histamine H2 receptors, thereby blocking the actions of histamine. Their clinically most important action is the inhibition of acid secretion in the treatment of gastrointestinal ulcers. Smooth muscle may also be affected. Some drugs in this class have strong effects in the central nervous system, but these actions are not well understood.Pyloric Antrum: The region between the sharp indentation at the lower third of the STOMACH (incisura angularis) and the junction of the PYLORUS with the DUODENUM. Pyloric antral glands contain mucus-secreting cells and gastrin-secreting endocrine cells (G CELLS).Treatment Outcome: Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.Benzimidazoles: Compounds with a BENZENE fused to IMIDAZOLES.Gastric Acid: Hydrochloric acid present in GASTRIC JUICE.Organometallic Compounds: A class of compounds of the type R-M, where a C atom is joined directly to any other element except H, C, N, O, F, Cl, Br, I, or At. (Grant & Hackh's Chemical Dictionary, 5th ed)Endoscopy, Gastrointestinal: Endoscopic examination, therapy or surgery of the gastrointestinal tract.Esomeprazole: The S-isomer of omeprazole.Esophagitis, Peptic: INFLAMMATION of the ESOPHAGUS that is caused by the reflux of GASTRIC JUICE with contents of the STOMACH and DUODENUM.Stomach: An organ of digestion situated in the left upper quadrant of the abdomen between the termination of the ESOPHAGUS and the beginning of the DUODENUM.Gastroesophageal Reflux: Retrograde flow of gastric juice (GASTRIC ACID) and/or duodenal contents (BILE ACIDS; PANCREATIC JUICE) into the distal ESOPHAGUS, commonly due to incompetence of the LOWER ESOPHAGEAL SPHINCTER.Levofloxacin: The L-isomer of Ofloxacin.Urea: A compound formed in the liver from ammonia produced by the deamination of amino acids. It is the principal end product of protein catabolism and constitutes about one half of the total urinary solids.Anti-Infective Agents: Substances that prevent infectious agents or organisms from spreading or kill infectious agents in order to prevent the spread of infection.Pepsinogen A: This is one of 2 related pepsinogen systems in humans and is also known as pepsinogen. (The other is PEPSINOGEN C.) This includes isozymogens Pg1-Pg5 (pepsinogens 1-5, group I or products of PGA1-PGA5 genes). This is the main pepsinogen found in urine.Yogurt: A slightly acid milk food produced by fermentation due to the combined action of Lactobacillus acidophilus and Streptococcus thermophilus.Prospective Studies: Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.Ofloxacin: A synthetic fluoroquinolone antibacterial agent that inhibits the supercoiling activity of bacterial DNA GYRASE, halting DNA REPLICATION.Duodenitis: Inflammation of the DUODENUM section of the small intestine (INTESTINE, SMALL). Erosive duodenitis may cause bleeding in the UPPER GI TRACT and PEPTIC ULCER.Esophagitis: INFLAMMATION, acute or chronic, of the ESOPHAGUS caused by BACTERIA, chemicals, or TRAUMA.Peptic Ulcer Hemorrhage: Bleeding from a PEPTIC ULCER that can be located in any segment of the GASTROINTESTINAL TRACT.Drug Administration Schedule: Time schedule for administration of a drug in order to achieve optimum effectiveness and convenience.Treatment Failure: A measure of the quality of health care by assessment of unsuccessful results of management and procedures used in combating disease, in individual cases or series.Poliomyelitis: An acute infectious disease of humans, particularly children, caused by any of three serotypes of human poliovirus (POLIOVIRUS). Usually the infection is limited to the gastrointestinal tract and nasopharynx, and is often asymptomatic. The central nervous system, primarily the spinal cord, may be affected, leading to rapidly progressive paralysis, coarse FASCICULATION and hyporeflexia. Motor neurons are primarily affected. Encephalitis may also occur. The virus replicates in the nervous system, and may cause significant neuronal loss, most notably in the spinal cord. A rare related condition, nonpoliovirus poliomyelitis, may result from infections with nonpoliovirus enteroviruses. (From Adams et al., Principles of Neurology, 6th ed, pp764-5)Stomach Diseases: Pathological processes involving the STOMACH.Azithromycin: A semi-synthetic macrolide antibiotic structurally related to ERYTHROMYCIN. It has been used in the treatment of Mycobacterium avium intracellulare infections, toxoplasmosis, and cryptosporidiosis.Nifuratel: Local antiprotozoal and antifungal agent that may also be given orally.Danazol: A synthetic steroid with antigonadotropic and anti-estrogenic activities that acts as an anterior pituitary suppressant by inhibiting the pituitary output of gonadotropins. It possesses some androgenic properties. Danazol has been used in the treatment of endometriosis and some benign breast disorders.Rifabutin: A broad-spectrum antibiotic that is being used as prophylaxis against disseminated Mycobacterium avium complex infection in HIV-positive patients.Hypoproteinemia: A condition in which total serum protein level is below the normal range. Hypoproteinemia can be caused by protein malabsorption in the gastrointestinal tract, EDEMA, or PROTEINURIA.Endoscopy: Procedures of applying ENDOSCOPES for disease diagnosis and treatment. Endoscopy involves passing an optical instrument through a small incision in the skin i.e., percutaneous; or through a natural orifice and along natural body pathways such as the digestive tract; and/or through an incision in the wall of a tubular structure or organ, i.e. transluminal, to examine or perform surgery on the interior parts of the body.Purpura, Thrombocytopenic, Idiopathic: Thrombocytopenia occurring in the absence of toxic exposure or a disease associated with decreased platelets. It is mediated by immune mechanisms, in most cases IMMUNOGLOBULIN G autoantibodies which attach to platelets and subsequently undergo destruction by macrophages. The disease is seen in acute (affecting children) and chronic (adult) forms.Double-Blind Method: A method of studying a drug or procedure in which both the subjects and investigators are kept unaware of who is actually getting which specific treatment.Pylorus: The region of the STOMACH at the junction with the DUODENUM. It is marked by the thickening of circular muscle layers forming the pyloric sphincter to control the opening and closure of the lumen.Drug Resistance, Bacterial: The ability of bacteria to resist or to become tolerant to chemotherapeutic agents, antimicrobial agents, or antibiotics. This resistance may be acquired through gene mutation or foreign DNA in transmissible plasmids (R FACTORS).Gastrins: A family of gastrointestinal peptide hormones that excite the secretion of GASTRIC JUICE. They may also occur in the central nervous system where they are presumed to be neurotransmitters.Sucralfate: A basic aluminum complex of sulfated sucrose.Follow-Up Studies: Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.Probiotics: Live microbial DIETARY SUPPLEMENTS which beneficially affect the host animal by improving its intestinal microbial balance. Antibiotics and other related compounds are not included in this definition. In humans, lactobacilli are commonly used as probiotics, either as single species or in mixed culture with other bacteria. Other genera that have been used are bifidobacteria and streptococci. (J. Nutr. 1995;125:1401-12)Tetragastrin: L-Tryptophyl-L-methionyl-L-aspartyl-L-phenylalaninamide. The C-terminal tetrapeptide of gastrin. It is the smallest peptide fragment of gastrin which has the same physiological and pharmacological activity as gastrin.Rosacea: A cutaneous disorder primarily of convexities of the central part of the FACE, such as FOREHEAD; CHEEK; NOSE; and CHIN. It is characterized by FLUSHING; ERYTHEMA; EDEMA; RHINOPHYMA; papules; and ocular symptoms. It may occur at any age but typically after age 30. There are various subtypes of rosacea: erythematotelangiectatic, papulopustular, phymatous, and ocular (National Rosacea Society's Expert Committee on the Classification and Staging of Rosacea, J Am Acad Dermatol 2002; 46:584-7).Recurrence: The return of a sign, symptom, or disease after a remission.Patient Compliance: Voluntary cooperation of the patient in following a prescribed regimen.Antibodies, Bacterial: Immunoglobulins produced in a response to BACTERIAL ANTIGENS.Biopsy: Removal and pathologic examination of specimens in the form of small pieces of tissue from the living body.Precancerous Conditions: Pathological processes that tend eventually to become malignant. (From Dorland, 27th ed)Randomized Controlled Trials as Topic: Works about clinical trials that involve at least one test treatment and one control treatment, concurrent enrollment and follow-up of the test- and control-treated groups, and in which the treatments to be administered are selected by a random process, such as the use of a random-numbers table.Gastric Juice: The liquid secretion of the stomach mucosa consisting of hydrochloric acid (GASTRIC ACID); PEPSINOGENS; INTRINSIC FACTOR; GASTRIN; MUCUS; and the bicarbonate ion (BICARBONATES). (From Best & Taylor's Physiological Basis of Medical Practice, 12th ed, p651)Parietal Cells, Gastric: Rounded or pyramidal cells of the GASTRIC GLANDS. They secrete HYDROCHLORIC ACID and produce gastric intrinsic factor, a glycoprotein that binds VITAMIN B12.Gastrointestinal Diseases: Diseases in any segment of the GASTROINTESTINAL TRACT from ESOPHAGUS to RECTUM.Bacterial Proteins: Proteins found in any species of bacterium.NitroimidazolesLithostathine: The proteinaceous component of the pancreatic stone in patients with PANCREATITIS.Anti-Inflammatory Agents, Non-Steroidal: Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions.They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects.Poliovirus Vaccine, Oral: A live vaccine containing attenuated poliovirus, types I, II, and III, grown in monkey kidney cell tissue culture, used for routine immunization of children against polio. This vaccine induces long-lasting intestinal and humoral immunity. Killed vaccine induces only humoral immunity. Oral poliovirus vaccine should not be administered to immunocompromised individuals or their household contacts. (Dorland, 28th ed)Anti-Infective Agents, Local: Substances used on humans and other animals that destroy harmful microorganisms or inhibit their activity. They are distinguished from DISINFECTANTS, which are used on inanimate objects.Polyps: Discrete abnormal tissue masses that protrude into the lumen of the DIGESTIVE TRACT or the RESPIRATORY TRACT. Polyps can be spheroidal, hemispheroidal, or irregular mound-shaped structures attached to the MUCOUS MEMBRANE of the lumen wall either by a stalk, pedunculus, or by a broad base.Poliovirus Vaccines: Vaccines used to prevent POLIOMYELITIS. They include inactivated (POLIOVIRUS VACCINE, INACTIVATED) and oral vaccines (POLIOVIRUS VACCINE, ORAL).Immunologic Tests: Immunologic techniques involved in diagnosis.Diterpenes, Abietane: A group of DITERPENES cyclized into 3-ring PHENANTHRENES.Dracunculiasis: Infection with nematodes of the genus Dracunculus. One or more worms may be seen at a time, with the legs and feet being the most commonly infected areas. Symptoms include pruritus, nausea, vomiting, diarrhea, or asthmatic attacks.Microbial Sensitivity Tests: Any tests that demonstrate the relative efficacy of different chemotherapeutic agents against specific microorganisms (i.e., bacteria, fungi, viruses).Anemia, Iron-Deficiency: Anemia characterized by decreased or absent iron stores, low serum iron concentration, low transferrin saturation, and low hemoglobin concentration or hematocrit value. The erythrocytes are hypochromic and microcytic and the iron binding capacity is increased.Smallpox: An acute, highly contagious, often fatal infectious disease caused by an orthopoxvirus characterized by a biphasic febrile course and distinctive progressive skin eruptions. Vaccination has succeeded in eradicating smallpox worldwide. (Dorland, 28th ed)Drug Resistance, Microbial: The ability of microorganisms, especially bacteria, to resist or to become tolerant to chemotherapeutic agents, antimicrobial agents, or antibiotics. This resistance may be acquired through gene mutation or foreign DNA in transmissible plasmids (R FACTORS).Lactobacillus acidophilus: A species of gram-positive, rod-shaped bacteria isolated from the intestinal tract of humans and animals, the human mouth, and vagina. This organism produces the fermented product, acidophilus milk.Chronic Disease: Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care. (Dictionary of Health Services Management, 2d ed)Time Factors: Elements of limited time intervals, contributing to particular results or situations.Drug Costs: The amount that a health care institution or organization pays for its drugs. It is one component of the final price that is charged to the consumer (FEES, PHARMACEUTICAL or PRESCRIPTION FEES).Sensitivity and Specificity: Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)Controlled Clinical Trials as Topic: Works about clinical trials involving one or more test treatments, at least one control treatment, specified outcome measures for evaluating the studied intervention, and a bias-free method for assigning patients to the test treatment. The treatment may be drugs, devices, or procedures studied for diagnostic, therapeutic, or prophylactic effectiveness. Control measures include placebos, active medicines, no-treatment, dosage forms and regimens, historical comparisons, etc. When randomization using mathematical techniques, such as the use of a random numbers table, is employed to assign patients to test or control treatments, the trials are characterized as RANDOMIZED CONTROLLED TRIALS AS TOPIC.Single-Blind Method: A method in which either the observer(s) or the subject(s) is kept ignorant of the group to which the subjects are assigned.Feces: Excrement from the INTESTINES, containing unabsorbed solids, waste products, secretions, and BACTERIA of the DIGESTIVE SYSTEM.World Health: The concept pertaining to the health status of inhabitants of the world.Drug Combinations: Single preparations containing two or more active agents, for the purpose of their concurrent administration as a fixed dose mixture.RNA, Ribosomal, 23S: Constituent of 50S subunit of prokaryotic ribosomes containing about 3200 nucleotides. 23S rRNA is involved in the initiation of polypeptide synthesis.Polymerase Chain Reaction: In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.Cost-Benefit Analysis: A method of comparing the cost of a program with its expected benefits in dollars (or other currency). The benefit-to-cost ratio is a measure of total return expected per unit of money spent. This analysis generally excludes consideration of factors that are not measured ultimately in economic terms. Cost effectiveness compares alternative ways to achieve a specific set of results.Ghrelin: A 28-amino acid, acylated, orexigenic peptide that is a ligand for GROWTH HORMONE SECRETAGOGUE RECEPTORS. Ghrelin is widely expressed but primarily in the stomach in the adults. Ghrelin acts centrally to stimulate growth hormone secretion and food intake, and peripherally to regulate energy homeostasis. Its large precursor protein, known as appetite-regulating hormone or motilin-related peptide, contains ghrelin and obestatin.Immunization Programs: Organized services to administer immunization procedures in the prevention of various diseases. The programs are made available over a wide range of sites: schools, hospitals, public health agencies, voluntary health agencies, etc. They are administered to an equally wide range of population groups or on various administrative levels: community, municipal, state, national, international.Prevalence: The total number of cases of a given disease in a specified population at a designated time. It is differentiated from INCIDENCE, which refers to the number of new cases in the population at a given time.Lactobacillus: A genus of gram-positive, microaerophilic, rod-shaped bacteria occurring widely in nature. Its species are also part of the many normal flora of the mouth, intestinal tract, and vagina of many mammals, including humans. Pathogenicity from this genus is rare.Platelet Count: The number of PLATELETS per unit volume in a sample of venous BLOOD.Chromosomes, Human, Pair 18: A specific pair of GROUP E CHROMOSOMES of the human chromosome classification.IranDracunculus Nematode: A genus of nematode parasites which inhabit the body cavity, serous membranes, and connective tissues of vertebrates. The parasitic species in humans is Dracunculus medinensis.Retrospective Studies: Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.Chi-Square Distribution: A distribution in which a variable is distributed like the sum of the squares of any given independent random variable, each of which has a normal distribution with mean of zero and variance of one. The chi-square test is a statistical test based on comparison of a test statistic to a chi-square distribution. The oldest of these tests are used to detect whether two or more population distributions differ from one another.JapanDrug Resistance: Diminished or failed response of an organism, disease or tissue to the intended effectiveness of a chemical or drug. It should be differentiated from DRUG TOLERANCE which is the progressive diminution of the susceptibility of a human or animal to the effects of a drug, as a result of continued administration.Remission Induction: Therapeutic act or process that initiates a response to a complete or partial remission level.Carbon Isotopes: Stable carbon atoms that have the same atomic number as the element carbon, but differ in atomic weight. C-13 is a stable carbon isotope.Enzyme Inhibitors: Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction.Administration, Oral: The giving of drugs, chemicals, or other substances by mouth.Gerbillinae: A subfamily of the Muridae consisting of several genera including Gerbillus, Rhombomys, Tatera, Meriones, and Psammomys.Genotype: The genetic constitution of the individual, comprising the ALLELES present at each GENETIC LOCUS.Case-Control Studies: Studies which start with the identification of persons with a disease of interest and a control (comparison, referent) group without the disease. The relationship of an attribute to the disease is examined by comparing diseased and non-diseased persons with regard to the frequency or levels of the attribute in each group.Republic of Korea: The capital is Seoul. The country, established September 9, 1948, is located on the southern part of the Korean Peninsula. Its northern border is shared with the Democratic People's Republic of Korea.Pilot Projects: Small-scale tests of methods and procedures to be used on a larger scale if the pilot study demonstrates that these methods and procedures can work.Poliovirus: A species of ENTEROVIRUS which is the causal agent of POLIOMYELITIS in humans. Three serotypes (strains) exist. Transmission is by the fecal-oral route, pharyngeal secretions, or mechanical vector (flies). Vaccines with both inactivated and live attenuated virus have proven effective in immunizing against the infection.Hydrogen-Ion Concentration: The normality of a solution with respect to HYDROGEN ions; H+. It is related to acidity measurements in most cases by pH = log 1/2[1/(H+)], where (H+) is the hydrogen ion concentration in gram equivalents per liter of solution. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)Lewis Blood-Group System: A group of dominantly and independently inherited antigens associated with the ABO blood factors. They are glycolipids present in plasma and secretions that may adhere to the erythrocytes. The phenotype Le(b) is the result of the interaction of the Le gene Le(a) with the genes for the ABO blood groups.Antigens, Bacterial: Substances elaborated by bacteria that have antigenic activity.Pepsinogens: Proenzymes secreted by chief cells, mucous neck cells, and pyloric gland cells, which are converted into pepsin in the presence of gastric acid or pepsin itself. (Dorland, 28th ed) In humans there are 2 related pepsinogen systems: PEPSINOGEN A (formerly pepsinogen I or pepsinogen) and PEPSINOGEN C (formerly pepsinogen II or progastricsin). Pepsinogen B is the name of a pepsinogen from pigs.Americas: The general name for NORTH AMERICA; CENTRAL AMERICA; and SOUTH AMERICA unspecified or combined.Risk Factors: An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.Helicobacter: A genus of gram-negative, spiral-shaped bacteria that has been isolated from the intestinal tract of mammals, including humans. It has been associated with PEPTIC ULCER.Poliovirus Vaccine, Inactivated: A suspension of formalin-inactivated poliovirus grown in monkey kidney cell tissue culture and used to prevent POLIOMYELITIS.DNA, Bacterial: Deoxyribonucleic acid that makes up the genetic material of bacteria.Combined Modality Therapy: The treatment of a disease or condition by several different means simultaneously or sequentially. Chemoimmunotherapy, RADIOIMMUNOTHERAPY, chemoradiotherapy, cryochemotherapy, and SALVAGE THERAPY are seen most frequently, but their combinations with each other and surgery are also used.Dose-Response Relationship, Drug: The relationship between the dose of an administered drug and the response of the organism to the drug.Immunoglobulin G: The major immunoglobulin isotype class in normal human serum. There are several isotype subclasses of IgG, for example, IgG1, IgG2A, and IgG2B.Campylobacter: A genus of bacteria found in the reproductive organs, intestinal tract, and oral cavity of animals and man. Some species are pathogenic.Pepsinogen C: This is one of the 2 related pepsinogen systems in humans. It is found in prostate and seminal fluid whereas PEPSINOGEN A is not.Endoscopy, Digestive System: Endoscopic examination, therapy or surgery of the digestive tract.Enzyme-Linked Immunosorbent Assay: An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed.Serologic Tests: Diagnostic procedures involving immunoglobulin reactions.Achlorhydria: A lack of HYDROCHLORIC ACID in GASTRIC JUICE despite stimulation of gastric secretion.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Measles: A highly contagious infectious disease caused by MORBILLIVIRUS, common among children but also seen in the nonimmune of any age, in which the virus enters the respiratory tract via droplet nuclei and multiplies in the epithelial cells, spreading throughout the MONONUCLEAR PHAGOCYTE SYSTEM.
Cheung TK, Xia HH, Wong BC (January 2007). "Helicobacter pylori eradication for gastric cancer prevention". Journal of ... Over half of the world's population is colonized with H. pylori and it is estimated that H. pylori-positive patients have a 1-2 ... Barry Marshall Clonally transmissible cancer Harald zur Hausen Helicobacter pylori eradication protocols J. Robin Warren List ... pylori, especially if the H. pylori are cagA positive. The increase in 8-OHdG likely increases mutation. In addition, oxidative ...
Dyspepsia Peptic ulcer disease including after endoscopic treatment for bleeding As part of Helicobacter pylori eradication ... "Optimum duration of regimens for Helicobacter pylori eradication". Cochrane Database of Systematic Reviews. 12: CD008337. doi: ...
"Regression of autoimmune thrombocytopenia after eradication of Helicobacter pylori". Lancet. 352 (9131): 878. doi:10.1016/S0140 ... studies of the role of Helicobacter pylori in autoimmune thrombocytopenia; research on the pathogenesis of biliary tract stones ...
Goggin N, Rowland M, Imrie C, Walsh D, Clyne M, Drumm B (1998). "Effect of Helicobacter pylori eradication on the natural ... It is also used to find Helicobacter pylori. Intestinal mucins also take up the stain although not as strongly as campylobacter ...
... a low-cost alternative for Helicobacter pylori eradication in children". Jornal de pediatria. 84 (2): 160-5. doi:10.2223/JPED. ... Use in treating Helicobacter pylori infections has also been proposed. Furazolidone is also used for giardiasis (due to Giardia ...
The supplement also significantly decreased usual side effects of H. pylori eradication therapy including diarrhea and nausea. ... Saccharomyces boulardii supplementation and eradication of Helicobacter pylori infection". Alimentary Pharmacology & ... The addition of S. boulardii to the standard triple medication protocol for elimination of Helicobacter pylori infection showed ... a significant increase in eradication rates in a meta-analysis, though eradication rates were still not exceptional. ...
"Duodenal bicarbonate secretion: Eradication of Helicobacter pylori and duodenal structure and function in humans". ... In patients with duodenal ulcers, Helicobacter pylori eradication can restore mucosal bicarbonate secretion, and reduce the ...
Helicobacter pylori eradication protocols "P/74/2009: European Medicines Agency decision of 20 April 2009 on the granting of a ... "Update on triple therapy for eradication of Helicobacter pylori: current status of the art". Clinical and Experimental ... is a bismuth salt used in combination with antibiotics and a proton pump inhibitor for the treatment of Helicobacter pylori ...
... and proton-pump inhibitor-based triple regimens for the eradication of Helicobacter pylori in Chinese patients with gastritis ... Treatment for esophagitis Part of a multidrug regimen for Helicobacter pylori eradication, although omeprazole may be somewhat ... "Proton-pump inhibitors versus H2-receptor antagonists in triple therapy for Helicobacter pylori eradication". Nihon rinsho. ... "Omeprazole enhances efficacy of triple therapy in eradicating Helicobacter pylori". Gut. 37 (4): 477-81. doi:10.1136/gut.37.4. ...
... pylori eradication as compared with controls. Systematic reviews of eradication have been conducted, with varying results. A ... Controlled trials disagree about whether or not H. pylori eradication is beneficial in functional dyspepsia, with roughly half ... Moayyedi, P; Deeks, J; Talley, NJ (2003). "An update of the Cochrane systematic review of Helicobacter pylori eradication ... eradication of H. pylori, duodenal and gastric ulcers, and NSAID-induced ulcer healing and prevention, but not functional ...
Duration of first-line proton-pump inhibitor based triple therapy for Helicobacter pylori eradication". Annals of Internal ... Treatment of H. pylori infection can be completed by taking a triple therapy combination of omeprazole, amoxicillin, and ... "Current concepts in the management of Helicobacter pylori infection: the Maastricht III Consensus Report". Gut. 56 (6): 772-81 ...
2002). "mRNA expression of EGF receptor ligands in atrophic gastritis before and after Helicobacter pylori eradication". ...
... associated with Helicobacter pylori infection may respond to H pylori eradication therapy, although resumption of ... "Long-term effect of Helicobacter pylori eradication on the reversibility of acid secretion in profound hypochlorhydria". ... Bacterial overgrowth may cause false positive H. Pylori test results due to the change in pH from urease activity. Small bowel ... 1997). "Helicobacter pylori infection and chronic gastric acid hyposecretion". Gastroenterology. 113 (1): 15-24. doi:10.1016/ ...
About 60% of MALT lymphomas completely regress with eradication therapy. Radiation treatment for H. pylori negative gastric ... May 1994). "Helicobacter pylori infection and gastric lymphoma". N. Engl. J. Med. 330 (18): 1267-71. doi:10.1056/ ... Risk factors for gastric lymphoma include the following: Helicobacter pylori Long-term immunosuppressant drug therapy HIV ... "Regression of primary gastric lymphoma of mucosa-associated lymphoid tissue type after cure of Helicobacter pylori infection. ...
... pylori eradication, which is now the mainstay of therapy. Fifty to 95% of cases achieve complete response (CR) with H. pylori ... "Most patients with minimal histological residuals of gastric MALT lymphoma after successful eradication of Helicobacter pylori ... positive gastric mucosa-associated lymphoid tissue lymphoma to Helicobacter pylori eradication therapy". Lancet. 357 (9249): 39 ... of primary low-grade B-cell gastric lymphoma of mucosa-associated lymphoid tissue type after eradication of Helicobacter pylori ...
... eradication of Heliobacter pylori show marked decreases in ammonia levels. Urease in peptic ulcers Helicobacter pylori is also ... "Role of Helicobacter pylori infection in the pathogenesis of minimal hepatic encephalopathy and effect of its eradication". ... Heliobacter pylori are microbial ureases found in the stomach. As ureases they hydrolyze urea to produce ammonia and carbonic ... Helicobacter pylori: Physiology and Genetics. Washington (DC): ASM Press. ISBN 1-55581-213-9. PMID 21290719. Molecular and ...
Ermis F, Akyuz F, Mungan Z. Recurrence of Helicobacter pylori after eradication in patient with peptic ulcer. South Med J. 105: ... After eradication of Helicobacter pylori infection relapse is a serious problem in Turkey. J Clin Gastroenterol, 28:241-244, ( ... Second-line levofloxacin-based triple therapy's efficiency for Helicobacter pylori eradication in patients with peptic ulcer. ... Besısık F, Sürücü F, Mungan Z, Dinçer D, Kapran Y, Kaymakoglu S, Çevikbaş U. Helicobacter pylori eredication lowers esophageal ...
Helicobacter pylori is linked to cancer, and antibiotic resistance impedes the success of current antibiotic-based eradication ... Ruggiero, Paolo (November 15, 2014). "Use of Probiotics in the fight against Helicobacter pylori". NCBI. 5 (4): 384-391. doi: ... species can be administered as probiotics during cases of infection by the ulcer-causing bacterium Helicobacter pylori. ...
Pimanov SI, Makarenko EV, Voropaeva AV, Matveenko ME, Voropaev EV (2008). "Helicobacter pylori eradication improves gastric ... "Barrett's esophagus is characterized by the absence of Helicobacter pylori infection and high levels of serum pepsinogen I ...
... eradication of H. pylori infection and reduction of side effects from standard H. pylori treatment, amelioration of gingivitis ... 2008). "Inhibition of Helicobacter pylori infection in humans by Lactobacillus reuteri ATCC 55730 and effect on eradication ... "Lactobacillus reuteri therapy to reduce side-effects during anti-Helicobacter pylori treatment in children: A randomized ... "Lactobacillus reuteri tablets suppress Helicobacter pylori infection--a double-blind randomised placebo-controlled cross-over ...
In 2006 the results of a Phase II study of Heliconda in around 130 patients with resistant H. pylori infection was published. ... This study demonstrated an eradication of the infection in 90.9% of patients treated with Heliconda. Ibaconda is a product for ... Heliconda, a product for the treatment of drug-resistant Helicobacter pylori, is a combination of the antibiotics rifabutin and ... for resistant Helicobacter pylori infection". Pubmed. 26 June 2006. Retrieved 6 June 2006. WO application 9850043 - US Patent ...
"Helicobacter pylori eradication therapy to prevent gastric cancer in healthy asymptomatic infected individuals: systematic ... Epidemiology of Helicobacter pylori and gastric cancer… Hatakeyama, M. & Higashi, H; Higashi (2005). "Helicobacter pylori CagA ... The mechanism by which H. pylori induces stomach cancer potentially involves chronic inflammation, or the action of H. pylori ... Helicobacter pylori infection is an essential risk factor in 65-80% of gastric cancers, but only 2% of people with Helicobacter ...
Part of a multidrug regimen for Helicobacter pylori eradication to reduce the risk of duodenal ulcer recurrence ...
As part of Helicobacter pylori eradication therapy. *Gastroesophageal reflux disease (GERD or GORD) including symptomatic ... "Optimum duration of regimens for Helicobacter pylori eradication". Cochrane Database of Systematic Reviews. 12: CD008337. doi: ...
Helicobacter pylori infection, alongside antibiotics (adjunctive treatment), treatment to kill H. pylori causing ulcers or ... See also: Helicobacter pylori eradication protocols. *#WHO-EM. *‡Withdrawn from market. *Clinical trials: *†Phase III ...
Part of a multidrug regimen for Helicobacter pylori eradication to reduce the risk of duodenal ulcer recurrence ...
RESULTS: By intention to treat analysis, Helicobacter pylori (H pylori) was eradicated in 73% and 76% of patients, respectively ... Eradication of the infection was considered when both the histologic examination and the urease test were negative for the ... One-week dual therapy with ranitidine bismuth citrate and clarithromycin for the treatment of Helicobacter pylori infection in ... well tolerated and effective for treatment of H pylori infection, and appears to be comparable to the 2-wk regimen in terms of ...
... pylori eradication rate and reduced the risk of overall H. pylori therapy-related adverse effects. In a cohort of patients in ... Achieving optimal eradication of H. pylori has proven difficult. Combination regimens that use two or three antibiotics with a ... Helicobacter pylori eradication protocols is a standard name for all treatment protocols for peptic ulcers and gastritis; the ... Patients with MALT lymphoma should also be tested and treated for H. pylori since eradication of this infection can induce ...
... pylori regimens that have a per-protocol eradication rate ≥90%. However, the eradication rate of the standard triple therapy ... In the paper entitled "Helicobacter pylori eradication therapies in the era of increasing antibiotic resistance: a paradigm ... In the paper entitled "7-day nonbismuth-containing concomitant therapy achieves a high eradication rate for Helicobacter pylori ... In the paper entitled "Recent insights into antibiotic resistance in Helicobacter pylori eradication," W. Wu et al. present the ...
... Guest Editors: Ping-I Hsu, Yoshio Yamaoka, Javier P. Gisbert, and Deng-Chyang Wu *H. pylori ... Helicobacter pylori Eradication Therapies in the Era of Increasing Antibiotic Resistance: A Paradigm Shift to Improved Efficacy ... Recent Insights into Antibiotic Resistance in Helicobacter pylori Eradication, Wenming Wu, Yunsheng Yang, and Gang Sun Volume ... 7-Day Nonbismuth-Containing Concomitant Therapy Achieves a High Eradication Rate for Helicobacter pylori in Taiwan, Sung-Shuo ...
New research suggests that eradication of Helicobacter pylori infection in the developed world may, at least in part, have ... The researchers explain that previous controlled trials have shown that, following successful H pylori eradication, patients ... Cite this: Does H pylori Eradication Explain Rising Obesity? - Medscape - Jun 09, 2014. ... with the latter unlikely to be driven by the eradication of H pylori. ...
Peptic Ulcer Duodenal Ulcer Pylorus Infection Dyspepsia Peptic Ulcer Disease These keywords were added by machine and not by ...
... pylori disease as adults? This new study explores the efficacy of bismuth-based therapy for children. ... a All children included in the analysis had apparently no history of previous treatment with H. pylori eradication therapy.. b ... a All children included in the analysis had apparently no history of previous treatment with H. pylori eradication therapy.. b ... a All children included in the analysis had apparently no history of previous treatment with H. pylori eradication therapy.. b ...
... pylori eradication. The aim of this study was to investigate the influence of pretreatment on cure rates of H. pylori ... The influence of pretreatment on cure rates of Helicobacter pylori eradication.. Janssen MJ1, Laheij RJ, Jansen JB, de Boer WA. ... pylori eradication. Three-day pretreatment with a proton pump inhibitor may decrease cure rates of this two-day quadruple ... pylori eradication than smokers and patients with functional dyspepsia, respectively (adjusted odds ratios: 4.79 (1.2-19) and ...
Will eradication of Helicobacter pylori improve symptoms of non-ulcer dyspepsia? BMJ 2000; 320 :1208 ... Will eradication of Helicobacter pylori improve symptoms of non-ulcer dyspepsia?. BMJ 2000; 320 doi: https://doi.org/10.1136/ ... these trials showed a much smaller summary estimate of eradication, which barely reaches significance (odds ratio 1.4, 95% ... that an improvement in dyspeptic symptoms occurred among patients with non-ulcer dyspepsia in whom Helicobacter pylori was ...
Helicobacter pylori / metabolism*. Hemorrhage. Humans. Infusions, Intravenous*. Male. Metronidazole / administration & dosage. ...
Levofloxacin-based triple therapy in first-line treatment for Helicobacter pylori eradication.. Nista EC1, Candelli M, Zocco MA ... A 7-day levofloxacin-based triple therapy can achieve higher H. pylori eradication rates than standard regimens. These data ... Recent studies suggested levofloxacin as an alternative option for both first-and second-line H. pylori eradication treatment. ... The standard first-line therapies for Helicobacter pylori eradication are based on clarithromycin and amoxicillin or ...
... pylori in an offshore island (Matsu) with a high prevalence of gastric cancer as well as premalignant gastric les ... Helicobacter pylori. (H. pylori) infection triggers this carcinogenic cascade and its eradication is currently. the most ... Community-based Helicobacter Pylori Eradication With Two Sequential Antibiotic Regimens for the Residents and Migrants From a ... Community-based Helicobacter Pylori Eradication With Two Sequential Antibiotic Regimens for the Residents and Migrants From a ...
Ideal length of treatment for Helicobacter pylori (H. pylori) eradication. *Antibiotics for people with peptic ulcers caused by ... Optimum antibiotic doses for Helicobacter pylori eradication. Primary objective To assess the effectiveness of different doses ... To compare the incidence of adverse effects associated with different doses of antibiotics for H. pylori eradication. ... Dental hygiene in addition to drug treatment for Helicobacter pylori eradication. *What is the best regimen of proton pump ...
Background The risk stratification of healthy individuals after Helicobacter pylorieradication is an urgent issue. The ... Changes in aberrant DNA methylation after Helicobacter pylori eradication: a long-term follow-up study. Int J Cancer. 2013;133: ... 1 Effects of H. pylori eradication on methylation levels of the nine candidate methylation markers. Methylation levels (upper ... The risk stratification of healthy individuals after Helicobacter pylori eradication is an urgent issue. The assessment of ...
Aizthromycin or Clarithromycin in H-pylori Eradication Regimen (H-pylori). The safety and scientific validity of this study is ... h-pylori eradication confirmation [ Time Frame: two months after completion of 14 days standard treatment ]. confirmation of ... Eradication of helicobacter pylori is important for treatment of GU but ideal regimen is not available. ... Comparison of Azithromycin or Clarithromycin in 3drugs Protocol of H-pylori Eradication Regimen. ...
... org/an-adaptive-evolution-of-helicobacter-pylori-role-of-the-caga-presence-in-the-outcome-of-h-pylori-eradication-in-children- ... Eradication of Helicobacter pylori in Children. Meta Description: A resistance to antibacterial drugs is a classic ... There is an evidence that Helicobacter pylori (H. pylori) has been colonizing humans for more than ten millions years or longer ...
Helicobacter Pylori Eradication and Motor Fluctuations in Parkinsons Disease. Clinical Intervention Awards, 2007. ... We will also verify H. pylori eradication at study completion. Relevance to Diagnosis/Treatment of Parkinsons Disease:. ... pylori infection with routine blood testing for antibodies to the bacterium. Those with evidence of H. pylori infection will be ... Treatment of H. pylori in patients with Parkinsons disease has been shown to improve clinical response to standard doses of ...
... Journal. The Journal of Infectious Diseases. ...
Aizthromycin or Clarithromycin in H-pylori Eradication Regimen (H-pylori). The safety and scientific validity of this study is ...
... pylori cure rate of standard 7-day clarithromycin-amoxycillin based triple therapy in non-ulcer dyspepsia patients. ... Results: H. pylori eradication following standard triple therapy was achieved in 53/68 (77.9%; 95% CI = 68-88) and in 53/66 ( ... Quadruple therapy with lactoferrin for Helicobacter pylori eradication: a randomised, multicentre study Dig Liver Dis. 2005 Jul ... Background: Helicobacter pylori eradication rate with standard triple therapies is decreasing. Recently, lactoferrin ...
... and allicin in HP eradication were evaluated. 210 patients who are HP positive in biopsy were involved in this study. The ... Helicobacter pylori eradication with beta carotene, ascorbic acid and allicin Acta Medica (Hradec Kralove). 2001;44(3):97-100. ... The eradication was achieved in 20 (66.6%) in group I, 15 (50%) in group II, 3 (10%) in group III, 15 (50%) in group IV, 0 (0 ... In this study, in vivo effectiveness of ascorbic acid (AA), beta carotene (BC) and allicin in HP eradication were evaluated. ...
"Helicobacter pylori", "H. pylori", "H pylori", "Campylobacter pylori", "C. pylori", "C pylori", "infection", "dyspepsia", " ... Global eradication.... *Global eradication rates for Helicobacter pylori infection: systematic review and meta-analysis of ... Results were expressed as relative risk for success of H pylori eradication and as difference in eradication rates among ... Global eradication rates for Helicobacter pylori infection: systematic review and meta-analysis of sequential therapy. BMJ 2013 ...
Helicobacter pylori eradication for premalignant lesions of the gastric mucosa. To assess the effect of Helicobacter pylori ... Ideal length of treatment for Helicobacter pylori (H. pylori) eradication. *First-line sequential versus standard triple ... Dental hygiene in addition to drug treatment for Helicobacter pylori eradication. *Effect of the long-term use of proton pump ... Helicobacter pylori eradication for premalignant lesions of the gastric mucosa. Cochrane Database of Systematic Reviews 2007, ...
... after Helicobacter pylori (HP) eradication. Methods: This is a prospective study over a period of 68 months (May 2009 - January ... HP eradication control was made after: 3 months, 6 months and one year of treatment. Results: During the study period, 1190 ... The eradication of HP was obtained in 98.41% with sequential treatment versus 88.73% with standard triple therapy (p = 0.026). ... The prevalence of infection with Helicobacter pylori (HP) in patients with functional dyspepsia is about 30% - 70%. The aim of ...
The possible link between IHD and Helicobacter pylori (H.pylori) inf ... CONCLUSIONS: H.pylori eradication is associated with modification of some clinical and biochemical parameters related to IHD ... The possible link between IHD and Helicobacter pylori (H.pylori) infection has been reported. However, the precise mechanism of ... Helicobacter pylori / pathogenicity*. Humans. Italy. Male. Middle Aged. Remission Induction. Risk Assessment. Risk Factors. ...
InfectionGastritisDyspepsiaAbstractMETHODSOmeprazoleAntibioticUrea breaHigher eradicationCure rates of Helicobacter pylori eradicationPathogenesisAmoxicillinImpact of Helicobacter pylori eradicationEradicateClinicalHumansHelicobacter pylori Eradication TherapyBacterialTriple therapyMetronidazoleConclusionsPeptic UlcerIncidence of Helicobacter pyloriChronicUnderwentRatesAsymptomaticOutcomeResistanceWeeks after eradication therapyDuodenal ulcersStomachPrevention of gastricPrevalence of Helicobacter pyloriRateGastric cancer development
- the primary goal is not only temporary relief of symptoms, but also total elimination of Helicobacter pylori infection. (wikipedia.org)
- Patients with MALT lymphoma should also be tested and treated for H. pylori since eradication of this infection can induce remission in many patients when the tumor is limited to the stomach. (wikipedia.org)
- As culture with antibiotic sensitivities is not routinely performed when a H. pylori infection is diagnosed, it is generally recommended that different antibiotics be given at higher doses for 14 days. (wikipedia.org)
- Recently, several treatment regimens have emerged to cure H. pylori infection. (hindawi.com)
- The main focus of the special issue is on the recent advances in the treatment of H. pylori infection. (hindawi.com)
- In the paper entitled " Pathogenesis of Helicobacter pylori-related gastroduodenal diseases from molecular epidemiological studies ," Y. Yamaoka presents African and Asian enigmas regarding high prevalence of H. pylori infection and low incidence of gastric cancer. (hindawi.com)
- In the paper entitled " The optimal first-line therapy of Helicobacter pylori infection in year 2012 ," C.-H. Kuo et al. (hindawi.com)
- review the literature about first-line therapies for H. pylori infection in the recent years. (hindawi.com)
- present critical issues regarding the currently available means for the management of H. pylori infection. (hindawi.com)
- The decline in Helicobacter pylori infection in the Western world over the past few decades may be at least partly responsible for the increased prevalence of obesity in those countries, a new meta-analysis suggests. (medscape.com)
- While our data may suggest that the decrease in H pylori prevalence observed in many countries in recent decades could be a contributing factor to the obesity endemic of the Western world, our study cannot rule out that other factors that are correlated with the risk of a H pylori infection are causal for the observed association," they point out. (medscape.com)
- Although the weight gain could be the result of improved postprandial symptoms in individuals treated for H pylori infection, it's also possible that a more complex relationship exists, they note. (medscape.com)
- 0.001) correlated with the prevalence of H pylori infection. (medscape.com)
- Helicobacter pylori is the source of a highly prevalent, serious and chronic infection that has been associated causally with a diverse spectrum of gastrointestinal disorders including chronic gastritis, peptic ulcer disease, gastric adenocarcinoma and gastric mucosa-associated lymphoid tissue lymphoma. (medscape.com)
- In general, it is hypothesised that spontaneous eradication of H. pylori infection is extremely rare. (medscape.com)
- The combination of a proton pump inhibitor (PPI) and two antibiotics (clarithromycin plus amoxicillin or metronidazole) has been the recommended first-line therapy since the first published guidelines for H. pylori infection in children. (medscape.com)
- [ 9 , 10 ] Recently, ESPGHAN and NASPGHAN jointly renewed clinical guidelines for H. pylori infection in children using a standardised evidence based approach. (medscape.com)
- Many patients treated for H. pylori infection have been taking a proton pump inhibitor beforehand. (nih.gov)
- To compare efficacy and tolerability of two different 7-day standard triple therapies versus 7-day levofloxacin-based triple therapy in first-line treatment for H. pylori infection. (nih.gov)
- H. pylori) infection triggers this carcinogenic cascade and its eradication is currently the most reliable regimen to arrest the histologic progression in order to prevent gastric cancer. (knowcancer.com)
- Emerging data have suggested that the benefit of H. pylori treatment earlier in the course of infection is larger and cannot be outweighed by a disfavored discount rate as a result of different time horizons between early treatment and later benefit of averting advanced cancer. (knowcancer.com)
- In the Asia-Pacific area, however, virulent strains of H. pylori infection are highly prevalent and premalignant gastric lesions may have already developed at the take-off age of active intervention. (knowcancer.com)
- 1. Determine the efficacy of a novel regimen to treat the H. pylori infection in the general population. (knowcancer.com)
- Gastric mucosa was collected from eight healthy volunteers without H. pylori infection (G1), 75 healthy individuals with gastric atrophy (G2), and 94 gastric cancer patients (G3) after H. pylori eradication. (springer.com)
- Helicobacter pylori is a common bacterial infection often associated with disorders of the gastrointestinal tract. (michaeljfox.org)
- We will evaluate 1) the frequency of infection with H. pylori in PD patients who have wearing off symptoms and 2) whether treatment of these patients leads to reduced wearing off in a clinical setting. (michaeljfox.org)
- For this pilot study, we will enroll PD patients taking levodopa who have developed significant (at least 3 hours/day) wearing off and screen them for H. pylori infection with routine blood testing for antibodies to the bacterium. (michaeljfox.org)
- Those with evidence of H. pylori infection will be randomized in a double-blinded fashion to either early or late treatment with a standard antibiotic regimen, receiving placebo treatment during the other time period. (michaeljfox.org)
- If a significant proportion of PD patients have H. pylori infection, and treatment results in clinically meaningful improvement, then this would justify screening for and treatment of H. pylori infection in other similarly affected patients. (michaeljfox.org)
- We evaluated the frequency of infection with H. pylori in PD patients and whether treatment of these patients leads to reduced wearing off. (michaeljfox.org)
- In summary, this preliminary study suggests that the incidence of H. pylori infection is lower in at least some populations than previously believed but the benefits of treatment could not be adequately accessed. (michaeljfox.org)
- Overall, 133 consecutive patients with non-ulcer dyspepsia and H. pylori infection were randomised to receive either a standard 7-day triple therapy with esomeprazole 20mg b.i.d., clarithromycin 500 mg b.i.d. and amoxycillin 1g b.i.d. (68 patients) or a quadruple therapy comprising of the same regimen plus lactoferrin 200mg b.i.d. (65 patients). (nih.gov)
- Helicobacter pylori infection causes peptic ulcers, gastric mucosa associated lymphoid tissue lymphoma, and gastric cancer. (bmj.com)
- 1 Standard treatments for H pylori infection that have been endorsed by US as well as European scientific societies and by regulatory authorities rely on clarithromycin, metronidazole, or amoxicillin in conjunction with gastric acid inhibitors. (bmj.com)
- 2 3 The prevalence of resistance to clarithromycin and metronidazole has increased substantially in recent years, and a corresponding decrease has occurred in the eradication rate for H pylori infection, 4 which has declined to unacceptable levels in most Western countries. (bmj.com)
- The possible link between IHD and Helicobacter pylori (H.pylori) infection has been reported. (biomedsearch.com)
- Do we really have longitudinal studies of sufficient duration to know the actual long-term risks associated with continued H. pylori infection? (annals.org)
- Helicobacter pylori infection is a crucial factor in the multistep carcinogenic process of gastric cancer. (nih.gov)
- Background and study aim: This study proposed to assess the relation between absolute telomere lengths (TLs) in gastric mucosa and Helicobacter pylori (H. pylori) infection and study the impact of (H. pylori) eradication therapy on TLs. (who.int)
- HealthDay News) - Type 2 diabetes mellitus increases the risk for gastric cancer after treatment for Helicobacter pylori infection, according to a study published online in Diabetes Care . (renalandurologynews.com)
- Ka Shing Cheung, MBBS, MPH, from The University of Hong Kong, and colleagues gathered data from 46,460 patients in Hong Kong who were aged 45 years or older and had received clarithromycin-based triple therapy for H. pylori infection, consisting of a proton pump inhibitor prescribed with clarithromycin and either amoxicillin or metronidazole. (renalandurologynews.com)
- Hwang JJ, Lee DH, Lee AR, Yoon H, Shin CM, Park YS, Kim N. Efficacy of moxifloxacin-based sequential therapy for first-line eradication of Helicobacter pylori infection in gastrointestinal disease. (wjgnet.com)
- Although epidemiological studies strongly suggest an association between gastric cancer and Helicobacter pylori infection, there has been no clinical report indicating that cure of the infection prevents cancer. (aacrjournals.org)
- One hundred and thirty-two patients with early gastric cancer underwent ER and had H. pylori infection. (aacrjournals.org)
- Several studies suggest that H. pylori chronic gastritis, particularly when associated with H. pylori - cagA -positive infection, correlates inversely with severe reflux esophagitis, Barrett's esophagus, and a higher risk of distal esophageal and cardia adenocarcinoma ( 10 -13 ). (aacrjournals.org)
- This analysis assessed the cost-effectiveness of universal post-treatment testing to confirm eradication of H. pylori infection in adults. (rti.org)
- In addition to testing costs, excess lifetime costs and reduced quality-adjusted life-years (QALYs) due to continuing H. pylori infection were considered in the model. (rti.org)
- CONCLUSION: Universal post-treatment testing was found to be cost-effective for confirming eradication of H. pylori infection following first-line therapy. (rti.org)
- Helicobacter pylori infection and the development of gastric cancer. (springer.com)
- Eradication of Helicobacter pylori Infection-Related Diseases. (alliedacademies.org)
- Although H. pylori infection does not cause illness in most infected people, it is a major risk factor for peptic ulcer disease and is responsible for the majority of ulcers of the stomach and upper small intestine. (alliedacademies.org)
- Infection with H. pylori is also associated with an increased risk of esophageal adenocarcinoma, (NCI, 2016) most likely from increased acid reflux causing Barrett's Esophagus, a precancerous state. (alliedacademies.org)
- The tests for detection of H. pylori infection include non-invasive tests such as urea breath test and stool H. pylori antigen test. (alliedacademies.org)
- We aim to define eradication of H. pylori infection based on the serum IgG titers. (alliedacademies.org)
- Despite a completion of a two-week course of therapy, some patients may continue to exhibit recurrent symptoms of H. pylori infection, probably indicating an ongoing low grade infection. (alliedacademies.org)
- This is a better indicator of eradication of H. pylori infection. (alliedacademies.org)
- If the titers are positive, then the initial two-week treatment is considered inadequate for the eradication of H. pylori infection. (alliedacademies.org)
- The current practice standard recommends against treatment of asymptomatic patients with H. pylori infection detected by serum IgG antibody testing. (alliedacademies.org)
- Histology of polyps from the stomach showed features of juvenile or retention type (hamartomatous) polyps with Helicobacter pylori (H. pylori) infection. (koreamed.org)
- Once a diagnosis of Helicobacter pylori infection has been established, current treatment consensus suggests that eradication therapy be prescribed for all patients with a history of peptic ulcer disease, since the eradication of Helicobacter pylori reduces the rate of ulcer recurrence. (infectioncontroltoday.com)
- To prevent infection and complications, local studies should be undertaken to evaluate H. pylori eradication rates in a country. (scielo.org.za)
- 120 patients with dyspepsia and H. pylori infection were randomised to receive esomeprazole, amoxicillin and clarithromycin for either 7 days (EAC 7) or 14 days (EAC 14). (scielo.org.za)
- H. pylori infection is usually contracted in the first few years of life and tends to persist indefinitely unless treated. (scielo.org.za)
- 141 patients (28%)-64 (26%) in the group that received testing plus eradication and 77 (31%) in the prompt endoscopy group-had H pylori infection. (bmj.com)
- 1 These studies add to the increasing literature that shows the benefits of evaluating patients with dyspepsia for H pylori infection before referral. (bmj.com)
- In North American patients with duodenal ulcers that are healed after Helicobacter pylori -eradication treatment, do ulcers recur less often in those without H. pylori infection than in those with persistent infection after treatment? (acpjc.org)
- In patients with healed duodenal ulcers after Helicobacter pylori -eradication treatment, patients without H. pylori infection have fewer ulcer recurrences than do those with persistent infection. (acpjc.org)
- Recognition of the importance of H. pylori in the pathogenesis of duodenal ulcer led to the expectation that eradication of the infection would cure the disease. (acpjc.org)
- Treating Helicobacter pylori infection in primary care patients with uninvestigated dyspepsia: the Canadian adult dyspepsia empiric treatment- Helicobacter pylori positive (CADET- Hp ) randomised controlled trial. (acpjc.org)
- In patients with Helicobacter pylori infection that was not eradicated after initial triple therapy, are 10-day levofloxacin-based triple regimens more effective than standard 7- or 14-day quadruple regimens for second-line eradication? (acpjc.org)
- In patients with Helicobacter pylori infection in whom triple therapy had previously failed, 10-day levofloxacin-based triple regimens were more effective and had fewer side effects than standard 10- or 14-day quadruple regimens. (acpjc.org)
- Currently, the recommended second-line treatment for H. pylori infection is quadruple therapy consisting of a proton-pump inhibitor, bismuth salt, metronidazole, and tetracycline for a minimum of 7 days. (acpjc.org)
- We aimed to evaluate AS and QTc dispersion in patients with HP infection and the effect of eradication treatment on these outcomes. (alliedacademies.org)
- The findings of this study indicate possible influence of HP infection on ventricular repolarization and a potential benefit of eradication on ventricular repolarization and measures of arterial stiffness. (alliedacademies.org)
- Infection with H. pylori is associated with severe gastrointestinal disease, including peptic ulceration, and eradication of the organism from the stomach facilitates duodenal ulcer healing and reduces ulcer relapse ( 16 , 28 ). (asm.org)
- The evidence of Helicobacter pylori infection appears more often in patients with central serous chorioretinopathy. (springermedizin.de)
- The purpose of this work was to estimate the efficiency of H. pylori infection eradication in treatment of patients with acute central serous chorioretinopathy. (springermedizin.de)
- To manage H. pylori infection, it is important to choose the appropriate regimen considering regional differences in resistance to clarithromycin and metronidazole. (springermedizin.de)
- Time Trends in Helicobacter pylori Infection and Atrophic Gastritis Over 40 Years in Japan. (springermedizin.de)
- H pylori infection affects more than 50% of the world's population. (crohnsforum.com)
- To our knowledge, no case of newly diagnosed ulcerative colitis occurring immediately after H pylori eradication therapy has previously been reported.A 63-year-old man received a diagnosis of chronic gastritis and H pylori infection. (crohnsforum.com)
- Clinical onset of the Crohn's disease after eradication therapy of Helicobacter pylori infection. (crohnsforum.com)
- Does Helicobacter pylori infection interact with natural history of inflammatory bowel diseases? (crohnsforum.com)
- There are conflicting reports concerning the prevalence of Helicobacter pylori infection in patients with inflammatory bowel diseases: some studies connected Sulphasalazine therapy and lower incidence of Helicobacter pylori infection, but others showed lower prevalence of Helicobacter pylori infection in inflammatory bowel diseases despite the choice of therapy. (crohnsforum.com)
- The clinical course of the Crohn's disease maybe 'sui generis' connected with Helicobacter pylori infection- but the exact mechanisms remain to be discovered. (crohnsforum.com)
- Background: The association between Helicobacter pylori infection and gastric cancer, which remains a major health problem in Japan, is well established. (aacrjournals.org)
- Methods: Using data in the literature and demographic statistics, the number of persons infected with H. pylori, the infection rate, and the number of those who developed gastric cancer by H. pylori were estimated. (aacrjournals.org)
- The number of persons who would be at risk of gastric cancer during their lives due to H. pylori infection was 750,000 when we assumed 2% as the risk of gastric cancer by H. pylori infection. (aacrjournals.org)
- The numbers of persons who would be at risk of gastric cancer due to the H. pylori infection in 2020, 2030 and 2050 would be 630,000, 490,000 and 220,000, respectively. (aacrjournals.org)
- Conclusions: The infection rate of H. pylori is gradually decreasing in younger people and it is necessary to consider the trend in the number of the infected people, the response rates of screening and that of eradication treatment for the economic evaluation. (aacrjournals.org)
- Helicobacter pylori (H. pylori) treatment remains a challenge for the clinician, as no available therapy is able to cure the infection in all treated patients. (openarchives.gr)
- Role of Helicobacter pylori coccoid forms in infection and recrudescence]. (semanticscholar.org)
- One hundred and fifty six children with H pylori infection ,2-14 years ,( 80 boys ) were randomly assigned to one of two regimens: 1-dual therapy with amoxicillin (50mg/kg/day) and omeprazole (3mg/kg/day) three time daily for 2 weeks. (clocate.com)
- Healthy volunteers with H. pylori infection, who saw a poster describing the study and wanted to participate. (isrctn.com)
- American College of Gastroenterology guideline on the management of Helicobacter pylori infection. (koreascience.or.kr)
- Clinical factors related with helicobacter pylori infection - is there an association with gastric cancer history in first- degree family members? (koreascience.or.kr)
- Effect of genotypic differences in CYP2C19 on cure rates for Helicobacter pylori infection by triple therapy with a proton pump inhibitor, amoxicillin, and clarithromycin. (koreascience.or.kr)
- Sequential therapy or triple therapy for Helicobacter pylori infection: systematic review and meta-analysis of randomized controlled trials in adults and children. (koreascience.or.kr)
- Meta-analysis: sequential therapy appears superior to standard therapy for Helicobacter pylori infection in patients naive to treatment. (koreascience.or.kr)
- Management of Helicobacter pylori infection--the maastricht iv/ florence consensus report. (koreascience.or.kr)
- Infection with H. pylori is the most common cause of duodenal ulcers. (encyclopedia.com)
- Thus, even after more than 20 years of experience in H pylori treatment, the ideal regimen to treat this infection still needs to be found. (hospitalpharmacyeurope.com)
- 3) Furthermore, several comparative randomised trials have demonstrated that both PPIs are equivalent in the eradication of the infection when prescribed with antibiotics. (hospitalpharmacyeurope.com)
- As esomeprazole provides better control of intragastric pH(14,15) and has a higher degree of activity against H pylori than other PPIs,(16) this compound could prove more effective to eradicate H pylori infection when combined with antibiotics. (hospitalpharmacyeurope.com)
- In summary, all PPIs are of similar efficacy for the eradication of H pylori infection when prescribed with antibiotics. (hospitalpharmacyeurope.com)
- Bismuth-based triple or quadruple therapies are effective to treat H pylori infection. (hospitalpharmacyeurope.com)
- In this study, the peripheral blood T cell subsets before and after eradication of H. pylori were analyzed to determine the influence of H. pylori infection on the systemic immune response. (scirp.org)
- Helicobacter pylori (H. pylori) infection is considered the main etiologic agent for gastric cancer development. (kjg.or.kr)
- In approximately 90% of cases, H. pylori infection plays the causative role in the pathogenesis, and H. pylori eradication is nowadays the first-line treatment for this disease, which leads to complete disease remission in 60-90% of cases. (elsevier.com)
- Predictive factors for resistance to eradication therapy include absence of H. pylori infection, deep invasion in the gastric wall, t(11:18)/API2-MALT1, and etc. (elsevier.com)
- Therefore, eradication of this H. pylori infection leads to ulcer healing and lowers the risk of gastric cancer. (grantome.com)
- Until the discovery of H. pylori, it was thought that stomach acid presented an inhospitable environment for bacterial infection. (grantome.com)
- H. pylori infection has a causal role in peptic ulcer disease and increases the risk of gastric cancer. (grantome.com)
- Since the report of culture of Helicobacter pylori in 1983, there has been increasing agreement that H. pylori infection is etiologically associated with a number of important diseases including chronic active gastritis, peptic ulcer disease, mucosa-associated lymphoid tissue (MALT) lymphoma, gastric polyps, gastric cancer, as well as suggestions that it may be involved in diseases outside the upper gastrointestinal tract. (eurekaselect.com)
- There have been a number of national and international consensus meetings to propose guidelines to treat H. pylori infection. (eurekaselect.com)
- Non-investigated dyspepsia is an indication for diagnostic evaluation and eradication therapy for those with H. pylori infection, whereas non-ulcer dyspepsia (NUD) in which peptic ulcer disease has been excluded is not an indication for evaluation per se. (eurekaselect.com)
- Because the prevalence of H. pylori infection and the associated diseases such as peptic ulcer or gastric cancer differ among countries as well as different approvals for treatment are required by governments or insurance agencies, the acceptable indications of eradication therapy will, by necessity, vary among countries. (eurekaselect.com)
- Background The prevalence of resistance to clarithromycin and metronidazole has considerably increased, with a corresponding decrease in the eradication rate for Helicobacter pylori (H. pylori) infection. (annalsgastro.gr)
- We aimed to assess the efficacy of a first-line 10-day, high-dose dual therapy consisting of amoxicillin and esomeprazole to eradicate H. pylori infection. (annalsgastro.gr)
- Randomised controlled trial of effects of Helicobacter pylori infection and its eradication on heartburn and gastro-oesophageal reflux: Bristol helicobacter project. (acponline.org)
- In patients with Helicobacter pylori infection, what is the effect of its eradication on symptoms of heartburn and gastroesophageal reflux? (acponline.org)
- 1558 patients who were 20 to 59 years of age (mean age 46 y, 51% women) with a 13 C -urea breath test (UBT) showing H. pylori infection. (acponline.org)
- In patients with Helicobacter pylori infection, treatment to eradicate H. pylori had no effect on heartburn or gastroesophageal reflux. (acponline.org)
- Data on children are limited to small case series.Procedure: Children from 16 centers in Italy, who were less than 18 years of age and diagnosed with chronic ITP (cITP), were screened for H. pylori infection. (elsevier.com)
- no response, PLT count 9/L.Results: Of 244 screened patients, 50 (20%) had H. pylori infection, 37 of which received eradication therapy and completed follow-up. (elsevier.com)
- We aimed to evaluate whether 10 day-sequential therapy eradicated H. pylori infection better than the PPI-based triple therapy in Korea. (bvsalud.org)
- Lack of effect of treating Helicobacter pylori infection in patients with nonulcer dyspepsia. (acponline.org)
- In patients with nonulcer (or functional) dyspepsia (NUD), does eradication of Helicobacter pylori infection relieve symptoms? (acponline.org)
- Peptic ulceration in the absence of nonsteroidal anti-inflammatory drugs is usually associated with H. pylori infection, and eradication is an effective treatment. (acponline.org)
- Helicobacter pylori infection is known as an important etiologic factor of the pathogenesis of MALT lymphoma. (bvsalud.org)
- To compare the efficacy and side effect profile of sequential and triple drug therapy in eradication of H pylori infection in Indian population. (tropicalgastro.com)
- The recent American College of Gastroenterology guidelines strongly recomm-end eradication of H pylori in all patients diagnosed with the infection using either non-invasive or endoscopic investigative modalities 3 . (tropicalgastro.com)
- In light of these findings the mAb-based Amplified IDEIA HpStAR has a high diagnostic accuracy for H. pylori infection in Turkish dyspeptic patients 6 weeks after completion of eradication therapy. (microbiologyresearch.org)
- Stool antigen assay (HpSA) is less reliable than urea breath test for post-treatment diagnosis of Helicobacter pylori infection. (microbiologyresearch.org)
- Detection of Helicobacter pylori infection in children with a standardized and simplified 13C-urea breath test. (microbiologyresearch.org)
- Accuracy of an enzyme immunoassay for the detection of Helicobacter pylori in stool specimens in the diagnosis of infection and posttreatment check-up. (microbiologyresearch.org)
- Stool antigen test for the diagnosis of Helicobacter pylori infection: a systematic review. (microbiologyresearch.org)
- Malfertheiner P. , Megraud F. , O'Morain C. , Hungin A. P. , Jones R. , Axon A. , Graham D. Y. , Tytgat G. the European Helicobacter Pylori Study Group (EHPSG) (2002) Current concepts in the management of Helicobacter pylori infection - the Maastricht Consensus Report. (microbiologyresearch.org)
- A 63-year-old man received a diagnosis of chronic gastritis and H pylori infection. (thepermanentejournal.org)
- 14,15 Along with the development of evaluating cancer risk by combined assay for H pylori infection and serum pepsinogen levels, namely the ABC method, 16 H pylori eradication therapy will prevail more than ever. (thepermanentejournal.org)
- Chronic gastritis and H pylori infection were diagnosed (Figure 1). (thepermanentejournal.org)
- The clarithromycin-based triple therapy is commonly used as empiric first line treatment for H pylori infection in Myanmar. (who.int)
- However, the efficacy of sequential treatment for Myanmar patients with H pylori infection has not been investigated. (who.int)
- 18 years with proved Helicobacter pylori infection were randomly assigned to receive either 10 day sequential therapy or 10 day triple therapy. (who.int)
- We examined the usefulness of a personalized therapy for H. pylori infection based on these factors as determined by genetic testing. (cdc.gov)
- Infection from H. pylori has been strongly associated with an increased incidence of gastric cancer. (2minutemedicine.com)
- Treatment for Helicobacter pylori infection cut the incidence of new gastric cancers in half among patients undergoing endoscopic resection of early gastric cancer, according to results of a recent randomized, placebo-controlled study. (mdedge.com)
- We speculate that persistent inflammation of gastric mucosa with H. pylori infection promotes carcinogenesis and also increases tumor growth or invasiveness," said Il Ju Choi, MD, PhD, of the Center for Gastric Cancer, National Cancer Center, Goyang, South Korea, and coauthors. (mdedge.com)
- The eradication rate of the first-line triple therapy (a proton pump inhibitor, clarithromycin, and amoxicillin) for Helicobacter pylori infection has gradually decreased in Korea. (kjim.org)
- Helicobacter pylori infection affects 54.4% of population in Korea [ 1 ]. (kjim.org)
- H. pylori infection can cause chronic gastritis, peptic ulcer disease (PUD), mucosa-associated lymphoid tissue lymphoma, and gastric cancer [ 2 , 3 ]. (kjim.org)
- Results using a Mongolian gerbil model revealed that H. pylori infection increased the incidence of carcinogen-induced adenocarcinoma, whereas curative treatment of H. pylori significantly lowered cancer incidence. (fujita-hu.ac.jp)
- The eradication of H. pylori infection continues to be a challenge due to the evolution of drug-resistant bacteria, lack of a gold standard diagnostic method, and ineffectiveness of current vaccines. (yildiz.edu.tr)
- Additionally, there still is no consensus in the literature about the main source of gastric H. pylori infection. (yildiz.edu.tr)
- Parsonnet, J., Freidman, G.D. and Vandersteen D.P. (1991) Helicobacter pylori infection and the risk of gastric carcinoma. (scirp.org)
- 2005) Phenotypic study of peripheral blood lymphocytes and humoral immune response in Helicobacter pylori infection according age. (scirp.org)
- The components in PREVPAC (PREVACID, amoxicillin , and clarithromycin ) are indicated for the treatment of patients with H. pylori infection and duodenal ulcer disease (active or one year history of a duodenal ulcer) to eradicate H. pylori . (rxlist.com)
- The aim of treatment of H. Pylori infection in any clinical situation is eradication of bacterium from the foregut with armamentarium of antibiotic to choice. (journalcra.com)
- Three hundred patients with documented H. pylori infection studied, were randomized into 3 groups to receive standard or sequential (clarithromycin or levofloxacin based) anti H. pylori therapy. (journalcra.com)
- Conclusion: In conclusion, our large, prospective, hospital based study shows the superiority of sequential treatment for eradicating H. pylori infection compared with conventional triple therapy. (journalcra.com)
- Our data suggest that sequential therapy may have a role as a first line treatment for H. pylori infection. (journalcra.com)
- This includes patients diagnosed with gastric adenocarcinoma (especially those with early-stage disease), patients found to have atrophic gastritis or intestinal metaplasia, as well as first-degree relatives of patients with gastric adenocarcinoma since the relatives themselves are at increased risk of gastric cancer partly due to the intrafamilial transmission of H. pylori. (wikipedia.org)
- Helicobacter pylori -associated gastritis causes accumulation of reactive oxygen species in the mucosal compartment. (aacrjournals.org)
- H. pylori eradication therapy for chronic gastritis achieved the world's first coverage by the Japanese national health insurance scheme in 2013, making a dramatic decrease of gastric cancer-related deaths more realistic. (springer.com)
- Prescriptions for H. pylori eradication therapy increased markedly after approval of the gastritis indication by the national health insurance scheme and were associated with a significant decrease in gastric cancer deaths. (springer.com)
- Helicobacter pylori is associated with several upper gastrointestinal conditions including chronic gastritis, peptic ulcer disease, and gatric malignancy. (scielo.org.za)
- Аннотация As a result of the conducted research results of an estimation of efficiency of application of the general eradication are presented therapy and local therapy at sick of inflammatory periodontal diseases against a chronic gastritis. (scipeople.ru)
- From June 1998 to December 2012 we assessed histologic and endoscopic findings of gastritis and performed H pylori eradication therapy in 748 patients without a history of gastric cancer. (snfge.org)
- Helicobacter pylori -associated gastritis leads to the development of gastric cancer. (springermedizin.de)
- Kyoto global consensus report on H. pylori gastritis recommended H. pylori eradication therapy to prevent gastric cancer. (springermedizin.de)
- Kyoto global consensus report on Helicobacter pylori gastritis. (springermedizin.de)
- Helicobacter pylori gastritis-a novel distinct disease entity. (springermedizin.de)
- In Japan, Helicobacter pylori eradication has been approved since 2013 for treatment of H pylori-induced chronic gastritis, in an attempt to reduce the prevalence of gastric cancer, a leading cancer in Japan. (crohnsforum.com)
- Histology examination of the biopsy specimen taken during the upper endoscopy revealed Helicobacter pylori associated active gastritis only in the corporal part of the stomach. (crohnsforum.com)
- Three months later, at the control endoscopy, granulomatous gastritis of the corporal localization was detected, without Helicobacter pylori present. (crohnsforum.com)
- Chronic inactive gastritis and coccoid Helicobacter pylori in patients treated for gastroesophageal reflux disease or with H pylori eradication therapy. (semanticscholar.org)
- H. pylori infected gastritis patients were randomized to receive 10-day sequential therapy and 14-day standard triple therapy. (koreascience.or.kr)
- Helicobacter pylori (H. pylori) is the most common pathogen of the gastrointestinal tract worldwide and the predominant cause of chronic gastritis, gastroduodenal ulcer, gastric lymphoma, and gastric cancer [1- (scirp.org)
- Other strong indications include MALT lymphoma, hyperplastic polyps, hyperplastic gastropathy, post-endoscopic resection for gastric malignancy, and acute H. pylori gastritis. (eurekaselect.com)
- The finding of a slightly higher prevalence of heartburn in patients infected with H. pylori is consistent with the greater probability of antral gastritis and acid hypersecretion reported in western countries. (acponline.org)
- In patients with nonulcer dyspepsia, eradication of Helicobacter pylori with omeprazole and antibiotics did not relieve symptoms but led to increased recovery from gastritis. (acponline.org)
- For eradication of Helicobacter pylori in antral gastritis, the conventional triple drug therapy comprising of amoxicillin, clarithromycin, and a proton pump inhibitor (PPI) is the most widely used first line therapy. (tropicalgastro.com)
- Three years later, eradication of H pylori was drastically expanded to include H pylori -induced chronic gastritis. (thepermanentejournal.org)
- 2,13 Namely, in February 2013, H pylori eradication was approved for H pylori -induced chronic gastritis in an attempt to reduce gastric cancer. (thepermanentejournal.org)
- The study by Choi and colleagues suggests Helicobacter pylori eradication is effective at stopping the carcinogenic process in patients with severe chronic atrophic gastritis, an advanced precursor lesion to gastric cancer, according to Peter Malfertheiner, MD. (mdedge.com)
- A total of 203 patients with H. pylori -positive chronic gastritis were consecutively enrolled. (kjim.org)
- Clarithromycin resistance and female gender are factors affecting H. pylori eradication failure in patients with chronic gastritis. (kjim.org)
- The bacterium Helicobacter pylori is known to colonize the human stomach and induce chronic atrophic gastritis, intestinal metaplasia, and gastric cancer. (fujita-hu.ac.jp)
- However, other reports have warned that human cases of atrophic metaplastic gastritis are already at risk for gastric cancer development, even after eradication of these bacteria. (fujita-hu.ac.jp)
- 1997) Different cytokine profile and antigen-specificity repertoire in Helicobacter pylori-specific T cell clones form the antrum of chronic gastritis patients with or without peptic ulcer. (scirp.org)
- H. pylori is the main cause of gastritis, peptic ulcer disease, gastric adenocarcinoma and mucosa associated lymphoid tissue lymphoma. (journalcra.com)
- Patients with H. pylori positive peptic ulcer disease or functional dyspepsia were treated with two-day quadruple therapy (lansoprazole 30 mg twice daily, and colloidal bismuth subcitrate 120 mg, tetracycline 250 mg and metronidazole 250 mg, all eight times a day). (nih.gov)
- Will eradication of Helicobacter pylori improve symptoms of non-ulcer dyspepsia? (bmj.com)
- EDITOR-Jaakkimainen et al's meta-analysis concludes that an improvement in dyspeptic symptoms occurred among patients with non-ulcer dyspepsia in whom Helicobacter pylori was eradicated. (bmj.com)
- Quadruple therapy with lactoferrin did not significantly increase the H. pylori cure rate of standard 7-day clarithromycin-amoxycillin based triple therapy in non-ulcer dyspepsia patients. (nih.gov)
- The aim of our study is to observe the improvement of functional dyspepsia (FD) after Helicobacter pylori ( HP ) eradication. (scirp.org)
- Sequential therapy is better than the standard triple therapy in the eradication of HP in patients with nonulcer dyspepsia, which improves their symptoms in more than 50% of cases. (scirp.org)
- mean age 59.7+/-2.3) with H.pylori-positive dyspepsia and/or peptic ulcer were studied after cure of the bacterium. (biomedsearch.com)
- I am troubled by Laine and colleagues' conclusion that there is little support for the use of H. pylori eradication therapy in patients with nonulcer dyspepsia (1) . (annals.org)
- Laine L, Fennerty MB, Schoenfeld P. Helicobacter pylori Eradication Therapy for Nonulcer Dyspepsia. (annals.org)
- This review presents a critical evaluation of the role of Helicobacter pylori eradication in the management of peptic ulcer disease and non-ulcer dyspepsia. (bmj.com)
- The role of H. pylori eradication in the treatment of gastric ulcer and non-ulcer dyspepsia is unclear and requires further study. (bmj.com)
- The role of H. pylori in nonulcer dyspepsia is less clear. (aafp.org)
- The objective of this review was to determine the effect of H. pylori eradication on dyspepsia symptoms and quality-of-life scores in patients with nonulcer dyspepsia. (aafp.org)
- Waluga M, Jonderko K, Krusiec-Świdergoł B, Kamińska M, Kasicka-Jonderko A, Lesińska M. Effect of Helicobacter pylori eradication on gastric emptying and symptoms in patients with dyspepsia. (termedia.pl)
- To study whether eradication of Helicobacter pylori (H. pylori) in patients with functional dyspepsia affects gastric emptying (GE) and concomitantly relieves their clinical symptoms. (termedia.pl)
- Eighteen H. pylori -positive patients suffering from functional dyspepsia were recruited. (termedia.pl)
- 1) Eradication of H. pylori in patients with functional dyspepsia prolongs the gastric half emptying time of a solid meal without eliciting a significant symptomatic improvement. (termedia.pl)
- All patients who presented between December 2009 and May 2010 with dyspepsia and who were positive for H. pylori on stool antigen tests were enrolled. (scielo.org.za)
- QUESTION: Is Helicobacter pylori testing plus eradication as effective and safe as prompt endoscopy in patients with dyspepsia? (bmj.com)
- Helicobacter pylori testing plus eradication was as effective and safe as prompt endoscopy for the primary care treatment of patients with dyspepsia but had greater patient dissatisfaction. (bmj.com)
- In patients with dyspepsia and a positive test result for Helicobacter pylori , is an H. pylori eradication strategy more effective than placebo for improving dyspepsia symptoms? (acpjc.org)
- 280 patients (mean age 48 y, 52% women) who had endoscopically confirmed nonulcer dyspepsia and a positive test result for H. pylori and in whom an eradication attempt with standard triple therapy had failed. (acpjc.org)
- The study included 120 patients in an out-patient treatment facility exhibiting H. pylori-positive non-ulcer dyspepsia and low total antioxidant capacity. (terrytalksnutrition.com)
- Total antioxidant capacity was lower than normal in all patients, however patients receiving AS in addition to ST achieved a higher percentage of H. pylori eradication in contrast to the group receiving ST only, indicating that Vitamins C and E may increase the eradication rate of H. Pylori and may be an effective adjunct to conventional treatment in patients with H. pylori and non-ulcer dyspepsia. (terrytalksnutrition.com)
- Patients and Methods: This study was conducted on (42) subjects divided into two groups, group I: included (17) H. pylori negative cases served as control group, group II: included (25) H. pylori positive patients. (who.int)
- Patients and Methods: Thirty-two consecutive H. pylori -positive patients underwent endoscopy with multiple biopsy sampling (i.e., antrum, incisura angularis, fundus, and cardia at the GEJ). (aacrjournals.org)
- In the present review, three main issues regarding H pylori treatment - especially related with PPIs - will be investigated using evidence-based methods. (hospitalpharmacyeurope.com)
- Methods Consecutive naÃ¯ve H. pylori-infected patients, who underwent an upper endoscopy in 4 Italian hospitals due to dyspeptic symptoms and found to be infected at routine histological assessment, were invited to participate. (annalsgastro.gr)
- Material and methods: Our hospital based, prospective, randomized study entitled "Sequential therapy versus standard triple therapy in Helicobacter pylori eradication" was conducted and concluded in post graduate department of Medicine, tertiary care institute in 2012. (journalcra.com)
- After the treatment with H. pylori eradication and omeprazole, the gastric polyposis, hypoalbuminemia and anemia regressed, and endoscopic polypectomy of gastric polyps were performed. (koreamed.org)
- Eradication of Helicobacter pylori provides potential cure in the majority of patients with peptic ulcer disease, and eradication rates of more than 90% have been reported, using omeprazole in combination with two antimicrobials. (diva-portal.org)
- Patients (n=787) with proved duodenal ulcer disease were randomized to treatment twice daily for 1 week with omeprazole, 20 mg (O), plus either placebo (P) or combinations of two of the following anti-microbials: amoxicillin, 1 gm (A), clarithromycin, 250 or 500 mg (C250, C500), or metronidazole, 400 mg (M). Eradication of H. pylori was evaluated by 13 C-UBT, performed before and 4 weeks after treatment cessation. (diva-portal.org)
- All studies tested 2-week dual therapy for eradicating H. pylori (2 studies used omeprazole plus clarithromycin, 2 used ranitidine bismuth citrate [RBC] plus amoxicillin, 2 used RBC plus clarithromycin, and 1 used omeprazole plus amoxicillin). (acpjc.org)
- and clarithromycin, 250 mg (eradication) ( n = 145), or omeprazole, 20 mg, and placebo metronidazole and placebo clarithromycin (placebo) ( n = 149) twice daily for 7 days. (acpjc.org)
- In a separate experiment, H. pylori -infected mice were administered either peptone trypsin broth or the mouse equivalent of 400 mg of metronidazole TID for 7 days, followed 1 month later by either peptone trypsin broth or the mouse equivalent of 20 mg of omeprazole, 250 mg of clarithromycin, and 400 mg of metronidazole twice a day for 7 days. (asm.org)
- After two weeks eradication therapy (Omeprazole, Amoxicillin ) he was well. (crohnsforum.com)
- Comparative study of H.pylori eradication rates of high and frequent dose of Omeprazole and Amoxicillin dual therapy versus standard triple therapy in children. (clocate.com)
- However, the results of a recent meta-analysis(17) showed that esomeprazole and omeprazole efficacies were similar for H pylori eradication when combined with two antibiotics (clarithromycin and either amoxicillin or metronidazole). (hospitalpharmacyeurope.com)
- The addition of the 13C-urea breath test and a second course of omeprazole, clarithromycin, and metronidazole achieved the highest eradication rate (97%) but was the most expensive (62.63 pounds per patient). (nihr.ac.uk)
- Of the strategies tested the most cost effective (omeprazole, clarithromycin, and metronidazole alone) was neither the least expensive (omeprazole, amoxycillin, and metronidazole alone) nor the most effective (omeprazole, clarithromycin, and metronidazole with further treatment for patients found positive for H pylori on 13C-urea breath testing). (nihr.ac.uk)
- The success of H. pylori cure depends on the type and duration of therapy, patient compliance and bacterial factors such as antibiotic resistance. (wikipedia.org)
- Patients most often fail to respond to initial H. pylori eradication therapy because of noncompliance or antibiotic resistance. (wikipedia.org)
- In the paper entitled " Recent insights into antibiotic resistance in Helicobacter pylori eradication ," W. Wu et al. (hindawi.com)
- present the antibiotic resistance rates in different continental areas and the impact of antibiotic resistances on the eradication of H. pylori . (hindawi.com)
- Cheng N, Xu K, Huang Y, Lim C. Optimum antibiotic doses for Helicobacter pylori eradication. (cochrane.org)
- The emerging problem of antibiotic resistance in H. pylori is of major clinical importance and a prime cause of treatment failure. (bmj.com)
- BACKGROUND: The treatment failure rate for Helicobacter pylori eradication therapy is ~20% due to poor patient compliance and increased antibiotic resistance. (rti.org)
- Metronidazole is commonly used to treat anaerobic and parasitic infections, and there is epidemiological evidence that metronidazole resistance in H. pylori is associated with prior use of this antibiotic in certain patient groups ( 2 , 4 , 11 , 13 , 37 ). (asm.org)
- Megraud F. H . pylori antibiotic resistance: prevalence, importance, and advances in testing. (springermedizin.de)
- Some national and international guidelines on H. pylori management have recently been updated, recommending or discouraging the use of each of these therapeutic approaches, based mainly on the presumed pattern of primary antibiotic resistance in different geographic areas. (openarchives.gr)
- Background: Studies of effects of IL-1 polymorphisms, CYP2C19 genotype together with antibiotic resistance for H. pylori eradication are rare worldwide. (koreascience.or.kr)
- But you don't have to worry about antibiotic resistance any longer as this simple stool test is able to identify whether you have a strain of H-pylori that is resistant to antibiotics. (h-pylori-symptoms.com)
- Antibiotic resistance and poor compliance are the main causes of Helicobacter pylori (H. pylori) eradication failure. (bvsalud.org)
- H. pylori status was rechecked by (13)C urea breath test 6 wk after the end of therapy. (nih.gov)
- H. pylori at entry was assessed by endoscopy, while bacterial eradication was checked by (13)C urea breath test 4-6 weeks after treatment. (nih.gov)
- The patients in this retrospective analysis tested negative for urea breath test, stool H. pylori antigen and gastric mucosa biopsy, but tested positive for IgG antibody titers. (alliedacademies.org)
- All patients had to have positive test results for H. pylori on the Helisal rapid blood test and the 13 C urea breath test. (acpjc.org)
- Eradication was confirmed by the results of the 13 C-urea breath test (UBT) at 12 wk after the therapy. (elsevier.com)
- At least 4 weeks after the end of the treatment a 13C-urea breath test was performed to evaluate the eradication. (annalsgastro.gr)
- Stool samples of patients were obtained 2 and 6 weeks after eradication therapy and a [ 13 C]urea breath test was performed 6 weeks after therapy in order to assess the reliability of mAb-based (Amplified IDEIA HpStAR, DakoCytomation) and polyclonal-antiserum-based (Premier Platinum HpSA, Meridian Diagnostics) stool antigen test kits and to compare their diagnostic accuracies. (microbiologyresearch.org)
- The outcomes of the eradication therapy were assessed 4 weeks after treatment by the 13C urea breath test. (who.int)
- Eradication was assessed by a 13 C-urea breath test 4 weeks after treatment. (kjim.org)
- Recently, a triple therapy with the combination of a PPI, levofloxacin, and amoxicillin has been proposed as an alternative to the standard rescue therapy and can achieve a higher eradication rate than a bismuth-containing quadruple therapy in some regions. (hindawi.com)
- In our study, Group B sequential therapy achieved 13% higher eradication as compared to standard triple therapy. (journalcra.com)
- This study has confirmed the presence of genes previously implicated in the pathogenesis of H pylori , as well as highlighted novel candidates for further investigation. (bmj.com)
- Helicobacter pylori and the pathogenesis of gastroduodenal inflammation. (springer.com)
- In gastric mucosa, H. pylori induces recruitment of CD4+ and CD8+ T cells and is suspected to be related to the pathogenesis of gastric inflammation . (scirp.org)
- Most recently, a 2013 large multicenter European controlled trial conducted in regions of high clarithromycin resistance reported 92% eradication with a 14-day quadruple therapy consisting of a proton pump inhibitor, amoxicillin, clarithromycin, and nitroimidazole (the latter not available in the United States). (wikipedia.org)
- First-line eradication triple therapy comprises a proton pump inhibitor (PPI) and two of the following antibiotics: clarithromycin, metronidazole and amoxicillin. (scielo.org.za)
- HP eradication was defined as a combination use of proton pump inhibitor or H2 receptor blockers, plus clarithromycin or metronidazole, plus amoxicillin or tetracycline, with or without bismuth, in the same prescription for 7-14 days. (springer.com)
- Unlike that to clarithromycin or metronidazole, H.pylori resistance to amoxicillin(AMO) remains uncommon. (clocate.com)
- Effect of dosing schemes of amoxicillin on eradication rates of Helicobacter pylori with amoxicillin-based triple therapy. (koreascience.or.kr)
- Primary resistance to amoxicillin is extremely low, and esomeprazole was found to exert a noteworthy antimicrobial activity in vitro against H. pylori. (annalsgastro.gr)
- Helicobacter pylori eradication rates by triple therapy with a proton pump inhibitor, amoxicillin, and clarithromycin at standard doses depend on bacterial susceptibility to clarithromycin and patient CYP2C19 genotypes. (cdc.gov)
- Aim To comprehensively review the clinical, pharmacologic and microbiologic properties of bismuth salts, and to summarise the evidence for the therapeutic efficacy of bismuth-based therapy for H. pylori eradication in children. (medscape.com)
- Clinical and biochemical parameters related to cardiovascular disease after Helicobacter pylori eradication. (biomedsearch.com)
- In order to investigate this issue, the authors assessed changes in clinical and biochemical parameters related to IHD after bacterial eradication. (biomedsearch.com)
- CONCLUSIONS: H.pylori eradication is associated with modification of some clinical and biochemical parameters related to IHD during a follow-up of five years. (biomedsearch.com)
- David Y. Graham, M.D., from the Baylor College of Medicine in Houston, and colleagues examined the effectiveness of RHB-105 for eradication of H. pylori in a phase 3 double-blind trial conducted at 55 clinical research sites in the United States. (doctorslounge.com)
- Real-world Helicobacter pylori diagnosis in patients referred for esophagoduodenoscopy: The gap between guidelines and clinical practice. (semanticscholar.org)
- Clinical features and efficacy of Helicobacter pylori (H. pylori) eradication for patients with gastric MALT lymphoma are reviewed. (elsevier.com)
- Recently a large-scale Japanese multicenter study demonstrated that the long-term clinical outcome of gastric MALT lymphoma after H. pylori eradication is excellent. (elsevier.com)
- On the other hand, eradication of H. pylori in populations where associated pangastritis and its attendant acid hyposecretion predominate could lead to different clinical outcomes, particularly in persons with preexisting GERD or a predisposition to GERD ( 3 ). (acponline.org)
- We evaluated whether clinical parameters, clarithromycin resistance, and CYP2C19 genotype can affect the eradication failure. (kjim.org)
- Eradication of H. pylori has been shown to reduce the risk of duodenal ulcer recurrence (see Clinical Studies and DOSAGE AND ADMINISTRATION ). (rxlist.com)
- There is an evidence that Helicobacter pylori (H. pylori) has been colonizing humans for more than ten millions years or longer. (omicsonline.org)
- Just like us humans, H-pylori bacteria have quite a wide variety of characteristics, and some of these increase its ability to cause harm. (h-pylori-symptoms.com)
- Furthermore, some epidemiological studies have shown that eradication of H. pylori reduces the development of metachronous cancer in humans. (fujita-hu.ac.jp)
- Effect on Helicobacter pylori eradication therapy against gastric cancer in Japan. (springermedizin.de)
- Onset of Ulcerative Colitis after Helicobacter pylori Eradication Therapy: A Case Report. (crohnsforum.com)
- Crohn's Disease Forum » Books, Multimedia, Research & News » Onset of Ulcerative Colitis after Helicobacter pylori Eradication Therapy: A Case Report. (crohnsforum.com)
- Background: Helicobacter pylori eradication therapy is commonly performed to reduce the incidence of gastric cancer. (elsevier.com)
- However, patients with large, refractory or complicated (eg, bleeding) ulcers should continue antisecretory therapy until bacterial eradication has been documented. (hospitalpharmacyeurope.com)
- Helicobacter pylori is a microaerophilic, gram negative, common human bacterial pathogen, acquired in childhood with a prevalence of around 80% in developing countries like ours 1 . (tropicalgastro.com)
- In a 2011 randomized, controlled trial, the per protocol eradication rates were 93% with quadruple therapy and 70% with triple therapy. (wikipedia.org)
- However, the eradication rate of the standard triple therapy recommended by most guidelines has generally declined to unacceptable levels (i.e., 80% or less) recently. (hindawi.com)
- A novel rifabutin-based triple therapy is effective for eradication of Helicobacter pylori , with eradication rates unaffected by resistance to clarithromycin or metronidazole, according to a study published online May 5 in the Annals of Internal Medicine . (doctorslounge.com)
- THURSDAY, May 7, 2020 (HealthDay News) -- A novel rifabutin-based triple therapy (RHB-105) is effective for eradication of Helicobacter pylori , with eradication rates unaffected by resistance to clarithromycin or metronidazole, according to a study published online May 5 in the Annals of Internal Medicine . (doctorslounge.com)
- In contrast, a recent study found that levofloxacin-based triple therapy was inferior to quadruple therapy (eradication rate 63% vs 83%) ( 3 ). (acpjc.org)
- In this study, researchers evaluated whether adding vitamins C and E to standard triple therapy increases the eradication rate of Helicobacter Pylori (H. Pylori). (terrytalksnutrition.com)
- Resistance to clarithromycin or metronidazole did not affect eradication rates. (doctorslounge.com)
- Mice colonized with the metronidazole-sensitive H. pylori SS1 strain were treated for 7 days with either peptone trypsin broth or the mouse equivalent of 400 mg of metronidazole once a day or three times per day (TID). (asm.org)
- These results demonstrate that H. pylori readily acquires resistance to metronidazole in vivo and that prior exposure of the organism to metronidazole is associated with failure of eradication therapy. (asm.org)
- However, previous use of metronidazole is frequently not reported by patients ( 11 ), and consequently the development of resistance in H. pylori after metronidazole monotherapy is poorly characterized. (asm.org)
- Dual therapy my provide an acceptable alternative first line therapy for H.pylori eradication in children in Egypt where high resistance rates to clarithromycin and metronidazole had been reported. (clocate.com)
- Nonsmokers and patients with peptic ulcer disease were more likely to achieve H. pylori eradication. (nih.gov)
- H. pylori is the main cause of peptic ulcer disease. (aafp.org)
- Laser capture microdissection (LCM) was used to extract mRNA from paraffin-embedded antral epithelium from 10 patients with peptic ulcer disease, before and after H pylori eradication. (bmj.com)
- The discovery of Helicobacter pylori ( H. pylori ) opened the doors to new insight and therapy for peptic ulcer disease. (diva-portal.org)
- Eradication therapy is considered the standard of care for active or inactive peptic ulcer patients including those who use non-steroidal anti-inflammatory drugs (NSAIDs). (eurekaselect.com)
- 348 patients who sought medical care for dyspeptic symptoms (pain or discomfort in the upper abdomen) that had persisted for ≥ 6 months, had no history of peptic ulcer disease or gastroesophageal disease, and tested positive for H. pylori . (acponline.org)
- Since H. pylori is a chronic infective condition, the use of IgG antibody as a marker of H. pylori chronic disease is useful to monitor disease activity. (alliedacademies.org)
- However, H. pylori possibly plays a role only in the first stage that leads to common chronic inflammation, but not in further stages leading to carcinogenesis. (wikipedia.org)
- They searched the literature for studies reporting on H pylori and obesity prevalence rates in random population samples of more than 100 subjects and discovered there was an inverse correlation between prevalence of the bacteria and rate of overweight/obesity in countries of the developed world. (medscape.com)
- In comparative studies, H. pylori eradication rates ranged between 69% and 85% according to ITT and between 74% and 96% PP. Side effects included dark stools, urine discoloration, black tongue, burning tongue, and marked darkness of the gums. (medscape.com)
- The aim of this study was to investigate the influence of pretreatment on cure rates of H. pylori eradication. (nih.gov)
- On a per- protocol basis (results in full accordance with the protocol established for the study), the eradication rates observed were 92 percent for the group treated with Helicide vs. 87 percent for the group treated with OAC. (infectioncontroltoday.com)
- Selective staining of gastric biopsies for H. pylori does not affect detection rates or turnaround time and improves cost compared to reflexive staining. (semanticscholar.org)
- The eradication rates as determined by per-protocol and intention-to-treat analyses were 65.9% and 63.0%,respectively. (elsevier.com)
- From the seven studies included in a recent meta-analysis(5) in which 534 patients received pantoprazole and 603 patients were given other PPIs, the mean H pylori eradication rates were 83% and 81%, respectively, indicating the equivalence of all PPIs. (hospitalpharmacyeurope.com)
- A placebo-controlled randomized trial of eradication of Helicobacter pylori in the general population: study design and response rates of the Bristol Helicobacter Project. (acponline.org)
- More patients in the eradication group were completely asymptomatic (Table). (acpjc.org)
- OBJECTIVES: To determine whether searching for Helicobacter pylori and treating with eradication therapy leads to a reduction in incidence of gastric cancer among healthy asymptomatic infected individuals. (whiterose.ac.uk)
- ELIGIBILITY CRITERIA FOR SELECTING STUDIES: Randomised controlled trials examining the effect of at least seven days of eradication therapy on subsequent occurrence of gastric cancer in adults who tested positive for Helicobacter pylori but otherwise healthy and asymptomatic were eligible. (whiterose.ac.uk)
- The prevalence of H. pylori in NUD has not been convincingly shown to differ from that in asymptomatic controls. (acponline.org)
- 1. Meta-analysis of trials involving eradication of Helicobacter pylori (H. pylori) in asymptomatic individuals showed significant decrease in gastric cancer incidence compared to placebo. (2minutemedicine.com)
- However, the use and benefit of screening and eradication of H. pylori in asymptomatic, healthy individuals is unclear. (2minutemedicine.com)
- Diabetes status and insulin use in patients with type 2 diabetes before 2005 were the main exposures of interest and the first event of HP eradication in 2005 was the main outcome evaluated. (springer.com)
- Intervention studies are now in progress to test the hypothesis that prevention of gastric malignancy is an outcome of H. pylori eradication. (eurekaselect.com)
- There are different articles about replacement clarithromycin with azithromycin as a method of eradication of HP that is decreases length of therapy and increases, effectiveness of drugs and decreases resistance of drugs. (clinicaltrials.gov)
- 3 The prevalence of antimicrobial resistance in H. pylori varies regionally within and between countries. (scielo.org.za)
- A clarithromycin resistance test was performed by detection of A2142G and A2143G point mutations in H. pylori 23S rRNA. (kjim.org)
- Clarithromycin resistance was detected in 33/190 patients (17.4%), and their eradication rate was zero. (kjim.org)
- Helicobacter pylori is now recognized as the primary cause of gastric and duodenal ulcers, which affect at least 10 percent of the North American population at some point. (infectioncontroltoday.com)
- What accounts for the higher prevalence of H. pylori -negative duodenal ulcers? (acpjc.org)
- About 95% of patients with duodenal ulcers are infected with H. pylori , as opposed to only 70% of patients with gastric ulcers. (encyclopedia.com)
- Thus, it seems that the majority of duodenal ulcers that do not heal initially despite H pylori eradication (in itself an uncommon occurrence) will ultimately heal several weeks later without additional therapy. (hospitalpharmacyeurope.com)
- Inoue K, Fujisawa T, Haruma K. Assessment of degree of health of the stomach by concomitant measurement of serum pepsinogen and serum Helicobacter pylori antibodies. (springer.com)
- It has been increasingly accepted that colonization of the stomach with H. pylori , is an important cause of gastric cancer and of gastric mucosa-associated lymphoid tissue (MALT) lymphoma (NCI, 2016). (alliedacademies.org)
- CagA and VacA are the H-pylori types that are most associated with stomach ulcers and stomach cancer. (h-pylori-symptoms.com)
- It is generally agreed that the inflammation caused by H-pylori in the stomach leads to changes elsewhere in the body, but don't worry: by using this test, you will be able to completely take charge of your long-term health. (h-pylori-symptoms.com)
- Helicobacter pylori infects the stomach of half of the world's population. (grantome.com)
- However, H. pylori has uniquely developed the means of surviving and growing on the acidic surface of the human stomach, a process termed acid acclimation. (grantome.com)
- H. pylori inhabits the stomach and has evolved unique acid response mechanisms to allow gastric colonization. (grantome.com)
- Individuals infected with H. pylori have a 10 to 20% lifetime risk of developing peptic ulcers and a 1 to 2% risk of acquiring stomach cancer. (wikipedia.org)
- Background: The belief that no organism can survive in the acidic environment of the stomach was shuttered by Barry Marshall and Robbin Warren in 1982 when they identified the organism Helicobacter pylori. (journalcra.com)
- There is increasing evidence of a link between H. pylori and gastric cancer but it is premature to recommend large-scale eradication of H. pylori as a valid strategy for the primary prevention of gastric cancer. (bmj.com)
- Cochrane Abstracts , Evidence Central , evidence.unboundmedicine.com/evidence/view/Cochrane/437794/all/Helicobacter_pylori_eradication_for_the_prevention_of_gastric_neoplasia:_Cochrane_systematic_review. (unboundmedicine.com)
- Also notable was the high rate of "spontaneous" H. pylori clearance in the placebo group. (acponline.org)
- However, a critical fall in the H. pylori eradication rate has been observed in the recent years. (bvsalud.org)
- The eradication rate was 64.0% according to intention-to-treat analysis and 68.4% by per-protocol analysis. (kjim.org)
- It means that the eradication rate is below 80% according to intention-to-treat (ITT) analysis and below 90% by the per-protocol (PP) analysis [ 4 , 5 ]. (kjim.org)