Impaired digestion, especially after eating.
A spiral bacterium active as a human gastric pathogen. It is a gram-negative, urease-positive, curved or slightly spiral organism initially isolated in 1982 from patients with lesions of gastritis or peptic ulcers in Western Australia. Helicobacter pylori was originally classified in the genus CAMPYLOBACTER, but RNA sequencing, cellular fatty acid profiles, growth patterns, and other taxonomic characteristics indicate that the micro-organism should be included in the genus HELICOBACTER. It has been officially transferred to Helicobacter gen. nov. (see Int J Syst Bacteriol 1989 Oct;39(4):297-405).
Infections with organisms of the genus HELICOBACTER, particularly, in humans, HELICOBACTER PYLORI. The clinical manifestations are focused in the stomach, usually the gastric mucosa and antrum, and the upper duodenum. This infection plays a major role in the pathogenesis of type B gastritis and peptic ulcer disease.
Inflammation of the GASTRIC MUCOSA, a lesion observed in a number of unrelated disorders.
Ulcer that occurs in the regions of the GASTROINTESTINAL TRACT which come into contact with GASTRIC JUICE containing PEPSIN and GASTRIC ACID. It occurs when there are defects in the MUCOSA barrier. The common forms of peptic ulcers are associated with HELICOBACTER PYLORI and the consumption of nonsteroidal anti-inflammatory drugs (NSAIDS).
Various agents with different action mechanisms used to treat or ameliorate PEPTIC ULCER or irritation of the gastrointestinal tract. This has included ANTIBIOTICS to treat HELICOBACTER INFECTIONS; HISTAMINE H2 ANTAGONISTS to reduce GASTRIC ACID secretion; and ANTACIDS for symptomatic relief.
Lining of the STOMACH, consisting of an inner EPITHELIUM, a middle LAMINA PROPRIA, and an outer MUSCULARIS MUCOSAE. The surface cells produce MUCUS that protects the stomach from attack by digestive acid and enzymes. When the epithelium invaginates into the LAMINA PROPRIA at various region of the stomach (CARDIA; GASTRIC FUNDUS; and PYLORUS), different tubular gastric glands are formed. These glands consist of cells that secrete mucus, enzymes, HYDROCHLORIC ACID, or hormones.
An organ of digestion situated in the left upper quadrant of the abdomen between the termination of the ESOPHAGUS and the beginning of the DUODENUM.
A 4-methoxy-3,5-dimethylpyridyl, 5-methoxybenzimidazole derivative of timoprazole that is used in the therapy of STOMACH ULCERS and ZOLLINGER-ELLISON SYNDROME. The drug inhibits an H(+)-K(+)-EXCHANGING ATPASE which is found in GASTRIC PARIETAL CELLS.
A semisynthetic macrolide antibiotic derived from ERYTHROMYCIN that is active against a variety of microorganisms. It can inhibit PROTEIN SYNTHESIS in BACTERIA by reversibly binding to the 50S ribosomal subunits. This inhibits the translocation of aminoacyl transfer-RNA and prevents peptide chain elongation.
A PEPTIC ULCER located in the DUODENUM.
An enzyme that catalyzes the conversion of urea and water to carbon dioxide and ammonia. EC 3.5.1.5.
The evacuation of food from the stomach into the duodenum.
A broad-spectrum semisynthetic antibiotic similar to AMPICILLIN except that its resistance to gastric acid permits higher serum levels with oral administration.
A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS. It has also been proposed as a radiation sensitizer for hypoxic cells. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985, p133), this substance may reasonably be anticipated to be a carcinogen (Merck, 11th ed).
Endoscopic examination, therapy or surgery of the interior of the stomach.
Endoscopic examination, therapy or surgery of the gastrointestinal tract.
The region of the STOMACH at the junction with the DUODENUM. It is marked by the thickening of circular muscle layers forming the pyloric sphincter to control the opening and closure of the lumen.
The region between the sharp indentation at the lower third of the STOMACH (incisura angularis) and the junction of the PYLORUS with the DUODENUM. Pyloric antral glands contain mucus-secreting cells and gastrin-secreting endocrine cells (G CELLS).
A metallic element that has the atomic symbol Bi, atomic number 83 and atomic weight 208.98.
Drugs used for their effects on the gastrointestinal system, as to control gastric acidity, regulate gastrointestinal motility and water flow, and improve digestion.
Substances that counteract or neutralize acidity of the GASTROINTESTINAL TRACT.
Diseases in any segment of the GASTROINTESTINAL TRACT from ESOPHAGUS to RECTUM.
Pathological processes involving the STOMACH.
Any tests done on exhaled air.
Ulceration of the GASTRIC MUCOSA due to contact with GASTRIC JUICE. It is often associated with HELICOBACTER PYLORI infection or consumption of nonsteroidal anti-inflammatory drugs (NSAIDS).
Tumors or cancer of the STOMACH.
Retrograde flow of gastric juice (GASTRIC ACID) and/or duodenal contents (BILE ACIDS; PANCREATIC JUICE) into the distal ESOPHAGUS, commonly due to incompetence of the LOWER ESOPHAGEAL SPHINCTER.
Compounds that inhibit H(+)-K(+)-EXCHANGING ATPASE. They are used as ANTI-ULCER AGENTS and sometimes in place of HISTAMINE H2 ANTAGONISTS for GASTROESOPHAGEAL REFLUX.
The motor activity of the GASTROINTESTINAL TRACT.
A substituted benzamide used for its prokinetic properties. It is used in the management of gastroesophageal reflux disease, functional dyspepsia, and other disorders associated with impaired gastrointestinal motility. (Martindale The Extra Pharmacopoeia, 31st ed)
Substances that reduce the growth or reproduction of BACTERIA.
Proteins found in any species of bacterium.
GASTRITIS with atrophy of the GASTRIC MUCOSA, the GASTRIC PARIETAL CELLS, and the mucosal glands leading to ACHLORHYDRIA. Atrophic gastritis usually progresses from chronic gastritis.
Spasmodic swallowing of air.
Inflammation of the DUODENUM section of the small intestine (INTESTINE, SMALL). Erosive duodenitis may cause bleeding in the UPPER GI TRACT and PEPTIC ULCER.
Chronic or recurrent colonic disorders without an identifiable structural or biochemical explanation. The widely recognized IRRITABLE BOWEL SYNDROME falls into this category.
Therapy with two or more separate preparations given for a combined effect.
A non-imidazole blocker of those histamine receptors that mediate gastric secretion (H2 receptors). It is used to treat gastrointestinal ulcers.
A 2,2,2-trifluoroethoxypyridyl derivative of timoprazole that is used in the therapy of STOMACH ULCERS and ZOLLINGER-ELLISON SYNDROME. The drug inhibits H(+)-K(+)-EXCHANGING ATPASE which is found in GASTRIC PARIETAL CELLS. Lansoprazole is a racemic mixture of (R)- and (S)-isomers.
Drugs that selectively bind to but do not activate histamine H2 receptors, thereby blocking the actions of histamine. Their clinically most important action is the inhibition of acid secretion in the treatment of gastrointestinal ulcers. Smooth muscle may also be affected. Some drugs in this class have strong effects in the central nervous system, but these actions are not well understood.
A nitroimidazole antitrichomonal agent effective against Trichomonas vaginalis, Entamoeba histolytica, and Giardia lamblia infections.
Sensation of discomfort, distress, or agony in the abdominal region.
Immunoglobulins produced in a response to BACTERIAL ANTIGENS.
Removal and pathologic examination of specimens in the form of small pieces of tissue from the living body.
Hydrochloric acid present in GASTRIC JUICE.
Substernal pain or burning sensation, usually associated with regurgitation of gastric juice into the esophagus.
A disorder with chronic or recurrent colonic symptoms without a clearcut etiology. This condition is characterized by chronic or recurrent ABDOMINAL PAIN, bloating, MUCUS in FECES, and an erratic disturbance of DEFECATION.
INFLAMMATION, acute or chronic, of the ESOPHAGUS caused by BACTERIA, chemicals, or TRAUMA.
This is one of 2 related pepsinogen systems in humans and is also known as pepsinogen. (The other is PEPSINOGEN C.) This includes isozymogens Pg1-Pg5 (pepsinogens 1-5, group I or products of PGA1-PGA5 genes). This is the main pepsinogen found in urine.
The shortest and widest portion of the SMALL INTESTINE adjacent to the PYLORUS of the STOMACH. It is named for having the length equal to about the width of 12 fingers.
Retrograde bile flow. Reflux of bile can be from the duodenum to the stomach (DUODENOGASTRIC REFLUX); to the esophagus (GASTROESOPHAGEAL REFLUX); or to the PANCREAS.
A condition in which there is a change of one adult cell type to another similar adult cell type.
A method of studying a drug or procedure in which both the subjects and investigators are kept unaware of who is actually getting which specific treatment.
Procedures of applying ENDOSCOPES for disease diagnosis and treatment. Endoscopy involves passing an optical instrument through a small incision in the skin i.e., percutaneous; or through a natural orifice and along natural body pathways such as the digestive tract; and/or through an incision in the wall of a tubular structure or organ, i.e. transluminal, to examine or perform surgery on the interior parts of the body.
The total number of cases of a given disease in a specified population at a designated time. It is differentiated from INCIDENCE, which refers to the number of new cases in the population at a given time.
Chronic delayed gastric emptying. Gastroparesis may be caused by motor dysfunction or paralysis of STOMACH muscles or may be associated with other systemic diseases such as DIABETES MELLITUS.
The ejection of gas or air through the mouth from the stomach.
The liquid secretion of the stomach mucosa consisting of hydrochloric acid (GASTRIC ACID); PEPSINOGENS; INTRINSIC FACTOR; GASTRIN; MUCUS; and the bicarbonate ion (BICARBONATES). (From Best & Taylor's Physiological Basis of Medical Practice, 12th ed, p651)
This is one of the 2 related pepsinogen systems in humans. It is found in prostate and seminal fluid whereas PEPSINOGEN A is not.
Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions.They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects.
A poly(dimethylsiloxane) which is a polymer of 200-350 units of dimethylsiloxane, along with added silica gel. It is used as an antiflatulent, surfactant, and ointment base.
The time frame after a meal or FOOD INTAKE.
A family of gastrointestinal peptide hormones that excite the secretion of GASTRIC JUICE. They may also occur in the central nervous system where they are presumed to be neurotransmitters.
A group of antibiotics that contain 6-aminopenicillanic acid with a side chain attached to the 6-amino group. The penicillin nucleus is the chief structural requirement for biological activity. The side-chain structure determines many of the antibacterial and pharmacological characteristics. (Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed, p1065)
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
Methods and procedures for the diagnosis of diseases or dysfunction of the digestive system or its organs or demonstration of their physiological processes.
A class of compounds of the type R-M, where a C atom is joined directly to any other element except H, C, N, O, F, Cl, Br, I, or At. (Grant & Hackh's Chemical Dictionary, 5th ed)
A genus of bacteria found in the reproductive organs, intestinal tract, and oral cavity of animals and man. Some species are pathogenic.
A subspecialty of internal medicine concerned with the study of the physiology and diseases of the digestive system and related structures (esophagus, liver, gallbladder, and pancreas).
A naphthacene antibiotic that inhibits AMINO ACYL TRNA binding during protein synthesis.
A compound formed in the liver from ammonia produced by the deamination of amino acids. It is the principal end product of protein catabolism and constitutes about one half of the total urinary solids.
Production or presence of gas in the gastrointestinal tract which may be expelled through the anus.
The S-isomer of omeprazole.
A group of dominantly and independently inherited antigens associated with the ABO blood factors. They are glycolipids present in plasma and secretions that may adhere to the erythrocytes. The phenotype Le(b) is the result of the interaction of the Le gene Le(a) with the genes for the ABO blood groups.
Organic compounds that have the general formula R-SO-R. They are obtained by oxidation of mercaptans (analogous to the ketones). (From Hackh's Chemical Dictionary, 4th ed)
Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.
Radiography of the gallbladder after ingestion of a contrast medium.
Full gratification of a need or desire followed by a state of relative insensitivity to that particular need or desire.
Pathological conditions in the DUODENUM region of the small intestine (INTESTINE, SMALL).
Dore MP, Pes GM, Bassotti G, Usai-Satta P (2016). "Dyspepsia: When and How to Test for Helicobacter pylori Infection". ... Over half of the world's population is colonized with H. pylori and it is estimated that H. pylori-positive patients have a 1-2 ... In addition to mutations caused by the direct damage to DNA by H. pylori-induced ROS, H. pylori-induced carcinogenic mutations ... These epigenetic alterations include H. pylori-induced methylation of CpG sites in promoters of genes and H. pylori-induced ...
Controlled trials disagree about whether or not H. pylori eradication is beneficial in functional dyspepsia, with roughly half ... Gastroenteritis increases the risk of developing chronic dyspepsia. Post infectious dyspepsia is the term given when dyspepsia ... The role of Helicobacter pylori in functional dyspepsia is controversial, and no clear causal relationship has been established ... Laine L, Schoenfeld P, Fennerty MB (2001). "Therapy for Helicobacter pylori in patients with nonulcer dyspepsia. A meta- ...
"The association between Helicobacter pylori infection and functional dyspepsia in patients with irritable bowel syndrome". The ... Rösch W, Liebregts T, Gundermann KJ, Vinson B, Holtmann G (2006). "Phytotherapy for functional dyspepsia: a review of the ... Gerards C, Leodolter A, Glasbrenner B, Malfertheiner P (2001). "H. pylori infection and visceral hypersensitivity in patients ... Some common examples of misdiagnosis include infectious diseases, coeliac disease, Helicobacter pylori, parasites (non- ...
"Proton Pump Inhibitor or Testing for Helicobacter pylori as the First Step for Patients Presenting with Dyspepsia? A Cluster- ...
... pylori infection had progressed to cause dyspepsia. Dyspepsia occurs in about 20% of infected individuals. In addition, as ... Dore MP, Pes GM, Bassotti G, Usai-Satta P (2016). "Dyspepsia: When and How to Test for Helicobacter pylori Infection". ... Infection by H. pylori causes no symptoms in about 80% of those infected. About 75% of individuals infected with H. pylori ... These epigenetic alterations are due to H. pylori-induced methylation of CpG sites in promoters of genes and H. pylori-induced ...
Helicobacter pylori eredication lowers esophageal sphincter pressures in functional dyspepsia patients. Hepato-Gastroenterology ... Ermis F, Akyuz F, Mungan Z. Recurrence of Helicobacter pylori after eradication in patient with peptic ulcer. South Med J. 105: ... After eradication of Helicobacter pylori infection relapse is a serious problem in Turkey. J Clin Gastroenterol, 28:241-244, ( ... Second-line levofloxacin-based triple therapy's efficiency for Helicobacter pylori eradication in patients with peptic ulcer. ...
... combined with other symptoms such as dyspepsia, nausea and heartburn may be a sign of an ulcer or hiatal hernia, and ... Other causes of burping include: food allergy, gallbladder diseases, esophageal reflux , H. pylori, acid reflux disease and ...
Abdominal aortic aneurysm Appendicitis Blunt force trauma to the abdomen Bowel obstruction Diverticulitis Dyspepsia Ectopic ... Gastrointestinal endoscopy may be used or patients with suspected peptic ulcer disease Helicobacter pylori testing may also be ... used Trial medications may be beneficial for the diagnosis and treatment of: GERD/dyspepsia: Proton pump inhibitors or H2 ...
Uncomplicated Helicobacter pylori infection does not cause chronic nausea. Food poisoning usually causes an abrupt onset of ... functional dyspepsia, gastritis, biliary reflux, gastroparesis, peptic ulcer, celiac disease, non-celiac gluten sensitivity, ...
... pylori infections have been associated with duodenal ulcer, gastric ulcer, nonulcer dyspepsia, and gastric cancer" (Graham 1). ... Helicobacter pylorus, previously known as Campylobacter pylori is a Gram-negative, microaerophilic bacterium infection usually ... People who are infected with the Campylobacter pylori should drink extra fluids as long as the diarrhea lasts. Antibiotics are ... Graham, David Y. "Campylobacter pylori and peptic ulcer disease." Gastroenterology 96.2 (1989): 615-625. Lockhart-Mummery, H. E ...
In addition, Helicobacter pylori which often occurs with Chagas would have caused Darwin to have peptic ulcer disease. Many of ... Gully agreed with Darwin's self-diagnosis of nervous dyspepsia and set him a routine including being heated by a spirit lamp ... On 16 May 1865, he wrote to John Chapman, who was now a qualified specialist in dyspepsia, sickness and psychological medicine ... Barry Marshall (12 February 2009). "What I know and what I think I know..: Darwins Illness was Helicobacter Pylori". Retrieved ...
... "in recognition of his work on discovering the role of Helicobacter pylori as a cause of diseases such as duodenal ulcer, ... gastric ulcer, gastric cancer and gastritis-associated dyspepsia" and won the Nobel Prize in Physiology or Medicine in 2005. ...
... as well as for the eradication of Helicobacter pylori and the relief of concomitant symptoms of dyspepsia, the following ... Bismuth citrate in vitro has a bactericidal effect on Helicobacter pylori, a protective effect on the gastric mucosa. Stomach ... ulcer and duodenal ulcer, including those associated with Helicobacter pylori (in combination with amoxicillin or ...
Dyspepsia Peptic ulcer disease including after endoscopic treatment for bleeding As part of Helicobacter pylori eradication ... PPI use in subjects who have received attempted H. pylori eradication may also be associated with an increased risk of gastric ... February 2007). "Effects of proton-pump inhibitors on functional dyspepsia: a meta-analysis of randomized placebo-controlled ... December 2013). "Optimum duration of regimens for Helicobacter pylori eradication". The Cochrane Database of Systematic Reviews ...
The actual cause of stomach cancer is not known but has been linked to infection with Helicobacter pylori, pernicious anemia, ... and dyspepsia. Many stomach diseases are associated with infection. Historically, it was widely believed that the highly acidic ... and stomach cancer are caused by Helicobacter pylori infection.[citation needed] One of the ways it is able to survive in the ...
... pylori infection had progressed to cause dyspepsia. Dyspepsia occurs in about 20% of infected individuals. In addition, as ... The bacterium was initially named Campylobacter pyloridis, then renamed C. pylori in 1987 (pylori being the genitive of pylorus ... Dore MP, Pes GM, Bassotti G, Usai-Satta P (2016). "Dyspepsia: When and How to Test for Helicobacter pylori Infection". ... H. pylori has been shown to increase the levels of COX2 in H. pylori positive gastritis. Chronic gastritis is likely to ...
... pylori. To date, it remains controversial whether to test and treat all patients with functional dyspepsia, gastroesophageal ... Helicobacter pylori eradication protocols is a standard name for all treatment protocols for peptic ulcers and gastritis in the ... The success of H. pylori cure depends on the type and duration of therapy, patient compliance and bacterial factors such as ... The primary goal is not only temporary relief of symptoms but also total elimination of H. pylori infection. Patients with ...
Peptic ulcers are most commonly caused by a bacterial Helicobacter pylori infection. Epstein-Barr virus infection is another ... Other common symptoms that stomach disease might cause include indigestion or dyspepsia, vomiting, and in chronic disease, ...
The first part, or superior part, of the duodenum is a continuation from the pylorus to transpyloric plane. It is superior to ... Duodenal ulcers may cause recurrent abdominal pain and dyspepsia, and are often investigated using a urea breath test to test ... This is distinct from the mucosa of the pylorus, which directly joins to the duodenum. Like other structures of the ... Ulcers of the duodenum commonly occur because of infection by the bacteria Helicobacter pylori. These bacteria, through a ...
If H. pylori is present it may be treated with a combination of antibiotics such as amoxicillin and clarithromycin. For those ... and management of dyspepsia". Osteopathic Family Physician. 5 (2): 79-85. doi:10.1016/j.osfp.2012.10.005. Boparai V, ... H. pylori was first discovered in 1981 by Barry Marshall and Robin Warren. Many people with gastritis experience no symptoms at ... Helicobacter pylori colonizes the stomachs of more than half of the world's population, and the infection continues to play a ...
Antibiotics are used if H. pylori is present.[citation needed] About 42% of the United States population has had heartburn at ... Duvnjak, edited by Marko (2011). Dyspepsia in clinical practice (1. Aufl. ed.). New York: Springer. p. 2. ISBN 9781441917300. ... "Initial management strategies for dyspepsia". Cochrane Database Syst Rev (4): CD001961. doi:10.1002/14651858.CD001961.pub2. ...
... Triple Therapies in Patients with Nonulcer Dyspepsia" (PDF). J Clin Microbiol. 39 (4): 1319-22. doi:10.1128 ... The bacterium was initially named Campylobacter pyloridis, then renamed C. pylori in 1987 (pylori being the genitive of pylorus ... Wikimedia Commons has media related to Helicobacter pylori.. *Information on tests for H. pylori from the National Institutes ... The pathogenicity of H. pylori may be increased by genes of the cag pathogenicity island; about 50-70% of H. pylori strains in ...
In digestive tissue, H. pylori can alter signaling in the brain-gut axis by mast cells, the main brain-gut axis effector ... The two most prevalent FGIDs, affecting up to 16-26% of worldwide population, are functional dyspepsia and irritable bowel ... Mast cells play a central pathophysiological role in IBS and possibly in functional dyspepsia, although not well defined. ▸ ... Budzyński J, Kłopocka M (2014). "Brain-gut axis in the pathogenesis of Helicobacter pylori infection". World J. Gastroenterol. ...
As part of Helicobacter pylori eradication therapy[8]. *Gastroesophageal reflux disease (GERD or GORD) including symptomatic ... 2007). "Effects of proton-pump inhibitors on functional dyspepsia: a meta-analysis of randomized placebo-controlled trials". ... and management of dyspepsia". Osteopathic Family Physician. 5 (2): 79-85. doi:10.1016/j.osfp.2012.10.005.. ... "Optimum duration of regimens for Helicobacter pylori eradication". Cochrane Database of Systematic Reviews. 12: CD008337. doi: ...
As part of Helicobacter pylori eradication therapy[8]. *Gastroesophageal reflux disease (GERD or GORD) including symptomatic ... 2007). "Effects of proton-pump inhibitors on functional dyspepsia: a meta-analysis of randomized placebo-controlled trials". ... Hagiwara T, Mukaisho K, Nakayama T, Hattori T, Sugihara H. Proton pump inhibitors and helicobacter pylori-associated ... and management of dyspepsia". Osteopathic Family Physician. 5 (2): 79-85. doi:10.1016/j.osfp.2012.10.005.. ...
UK) (2014). Dyspepsia and Gastro-Oesophageal Reflux Disease: Investigation and Management of Dyspepsia, Symptoms Suggestive of ... Antacids do not kill the bacteria Helicobacter pylori, which causes most ulcers. Antacids are known to interact with several ...
The endoscope is quickly passed through the stomach and through the pylorus to examine the first and second parts of the ... Irritable bowel syndrome and functional dyspepsia are not diagnosed with EGD, but EGD may be helpful in excluding other ... Endoscopic image of gastric antral vascular ectasia seen as a radial pattern around the pylorus before (top) and after (bottom ... Upper gastrointestinal bleeding as evidenced by hematemesis or melena Persistent dyspepsia in patients over the age of 45 years ...
Mild symptoms may appear such as dyspepsia, abdominal pain, constipation, or diarrhoea. However, under severe infection, ... pylori, which is primarily associated with ulcers, but also may cause stomach cancers). O. viverrini has 12 (six pairs) of ...
... inhibits H. pylori-derived urease, a multimeric nickel-containing enzyme that catalyses the hydrolysis of urea to ... In patients with APDs like dyspepsia, gastritis, GERD and/or gastric ulcer, uncontrolled with acid inhibitors viz. proton pump ... Mobley HL (1996). "The role of Helicobacter pylori urease in the pathogenesis of gastritis and peptic ulceration". Aliment ... The mitochondrion is the major target of intracellular oxidative stress associated with aggressive factors like H. pylori, ...
Helicobacter pylori eradication protocols In the United States, all four FDA-approved members of the group-cimetidine, ... H2 antagonists are used in the treatment of dyspepsia, although they have been surpassed in popularity by the more effective ... There are several classes of drugs for acid-related disorders, such as dyspepsia, peptic ulcer disease (PUD), gastroesophageal ...
The pylorus, the lowest section of the stomach which attaches to the duodenum via the pyloric canal, contains countless glands ...
Helicobacter pylori *Peptic ulcer, MALT lymphoma, Gastric cancer. *Helicobacter cinaedi *Helicobacter cellulitis ...
... with the cardia and pylorus as fixed points. In this situation the abnormality is usually referred to as an intrathoracic ...
Helicobacter pylori *Peptic ulcer, MALT lymphoma, Gastric cancer. *Helicobacter cinaedi *Helicobacter cellulitis ...
2003). "Stress, but not Helicobacter pylori, is associated with peptic ulcer disease in a Thai population". J Med Assoc Thai. ... See also: Timeline of peptic ulcer disease and Helicobacter pylori. ಈ ರೋಗಕ್ಕೆ ಸೂಕ್ಷ್ಮಜೀವಿಗಳೇ ಪ್ರಮುಖ ಕಾರಣ ಎಂದು ತಿಳಿದುಬರುವ ... Salih, Barik (June 2007). "H pylori infection and other risk factors associated with peptic ulcers in Turkish patients: A ... 2002). "Long-term stress and Helicobacter pylori infection independently induce gastric mucosal lesions in C57BL/6 mice". Scand ...
... pylori can lead to an increase in acid secretion,[31] leading to the question of whether H. pylori-infected GERD patients are ... and management of dyspepsia". Osteopathic Family Physician. 5 (2): 79-85. doi:10.1016/j.osfp.2012.10.005.. ... In 1999, a review of existing studies found that, on average, 40% of GERD patients also had H. pylori infection.[30] The ... 1997). "Helicobacter pylori infection and chronic gastric acid hyposecretion". Gastroenterology. 113 (1): 15-24. doi:10.1016/ ...
"Proton Pump Inhibitor or Testing for Helicobacter pylori as the First Step for Patients Presenting with Dyspepsia? A Cluster- ...
Although the exact role of Helicobacter pylori infection in PA remains controversial, evidence indicates H. pylori is involved ... dyspepsia, weight loss,[17] neuropathic pain, jaundice, sores at the corner of the mouth (angular cheilitis), a look of ... Antibodies produced by the immune system can be cross-reactive and may bind to both H. pylori antigens and those found in the ... Desai HG, Gupte PA (December 2007). "Helicobacter pylori link to pernicious anaemia". The Journal of the Association of ...
H. pylori[edit]. Helicobacter pylori is one of the major causative factors of peptic ulcer disease. It secretes urease to ... pylori infection, it does not seem to independently increase risk. Even when coupled with H. pylori infection, the increase is ... The H. pylori hypothesis was initially poorly received,[37] so in an act of self-experimentation Marshall drank a Petri dish ... Helicobacter pylori was identified in 1982 by two Australian scientists, Robin Warren and Barry J. Marshall, as a causative ...
Although the exact role of Helicobacter pylori infection in PA remains controversial, evidence indicates H. pylori is involved ... dyspepsia, weight loss, neuropathic pain, jaundice, sores at the corner of the mouth (angular cheilitis), a look of exhaustion ... Less commonly, H. pylori and Zollinger-Ellison syndrome may also cause a form of nonautoimmune gastritis that can lead to ... Antibodies produced by the immune system can be cross-reactive and may bind to both H. pylori antigens and those found in the ...
The eradication of H. pylori can lead to an increase in acid secretion, leading to the question of whether H. pylori-infected ... and management of dyspepsia". Osteopathic Family Physician. 5 (2): 79-85. doi:10.1016/j.osfp.2012.10.005. Kahrilas PJ (2008). " ... Investigation for H. pylori is not usually needed. The current gold standard for diagnosis of GERD is esophageal pH monitoring ... 1997). "Helicobacter pylori infection and chronic gastric acid hyposecretion". Gastroenterology. 113 (1): 15-24. doi:10.1016/ ...
Will eradication of Helicobacter pylori improve symptoms of non-ulcer dyspepsia? BMJ 2000; 320 :1208 ... Will eradication of Helicobacter pylori improve symptoms of non-ulcer dyspepsia?. BMJ 2000; 320 doi: https://doi.org/10.1136/ ... that an improvement in dyspeptic symptoms occurred among patients with non-ulcer dyspepsia in whom Helicobacter pylori was ...
... Hsi-Chang Lee,1 Ting-Chang Huang,1 Chin- ... This is because when corpus H. pylori infection occurs, antrum H. pylori infection exists already. Our studies have identified ... "Technical annex: tests used to assess Helicobacter pylori infection. Working party of the European Helicobacter pylori study ... pylori) infection in patients with dyspepsia. These tests included culture, histology, and the rapid urease test (CLO test). ...
... Hsi-Chang Lee,1 Ting-Chang Huang,1 Chin- ... "Performance of Routine Helicobacter pylori Invasive Tests in Patients with Dyspepsia," Gastroenterology Research and Practice, ...
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I want to know if this medication is correct? Also if this medication will eradicate the H.pylori infection?. Also should I ... My doctor later said that the symptoms indicated a possible ,b,H.pylori infection,/b, for which he suggested the following ... A:Your symptoms are suggestive of dyspepsia. There are several causes of dyspepsia including peptic ulcer disease. Since you ... My doctor later said that the symptoms indicated a possible H.pylori infection for which he suggested the following medications ...
H pylori and dyspepsia published before April 1999 and randomized trials of the effects of H pylori eradication on dyspepsia ... The available evidence indicates that there is no strong association between H pylori and dyspepsia, but there is insufficient ... Systematic review of the epidemiological evidence on Helicobacter pylori infection and nonulcer or uninvestigated dyspepsia.. ... To perform a systematic review of the literature to determine whether chronic infection with H pylori is relevant to nonulcer ...
The prevalence of infection with Helicobacter pylori (HP) in patients with functional dyspepsia is about 30% - 70%. The aim of ... In our study the prevalence of Helicobacter pylori infection in patients with functional dyspepsia is high: 70%. Sequential ... The average age in patients with functional dyspepsia was 49 years [16 - 80], sex ratio M/F was 0.58 (N = 92/158). 60% of ... our study is to observe the improvement of functional dyspepsia (FD) after Helicobacter pylori (HP) eradication. Methods: This ...
Dyspepsia was modestly reduced after the screening and treatment procedure, and the result was not sufficiently extensive to ... Rates of dyspepsia one year after Helicobacter pylori screening and eradication in a Danish population Gastroenterology. 2003 ... The prevalence of dyspepsia and the quality of life were assessed through a mailed questionnaire. Information on the use of ... Conclusions: Dyspepsia was modestly reduced after the screening and treatment procedure, and the result was not sufficiently ...
Helicobacter pylori Eradication Therapy for Nonulcer Dyspepsia. Ann Intern Med. 2002;136:555. doi: 10.7326/0003-4819-136-7- ... Therapy for Helicobacter pylori in Patients with Nonulcer Dyspepsia: A Meta-Analysis of Randomized, Controlled Trials ... pylori eradication therapy in patients with nonulcer dyspepsia (1). Since infected persons have a two- to sixfold increased ... Improvement in Atrophic Gastritis and Intestinal Metaplasia in Patients in Whom Helicobacter pylori Was Eradicated ...
Helicobacter pylori Eradication Therapy for Nonulcer Dyspepsia Loren Laine, MD; M. Brian Fennerty, MD; Philip Schoenfeld, MD, ... Therapy for Helicobacter pylori in Patients with Nonulcer Dyspepsia: A Meta-Analysis of Randomized, Controlled Trials ... Laine L, Fennerty MB, Schoenfeld P. Helicobacter pylori Eradication Therapy for Nonulcer Dyspepsia. Ann Intern Med. 2002;136: ... Analysis of studies in their review using the appropriate definition of dyspepsia shows no benefit (P = 0.5), just as in our ...
Blood sample based tests to detect the bacterium Helicobacter Pylori (HP) are useful in diagnosing peptic ulcer and suitable to ... significantly cost effective compared to the test with the highest specificity when the willingness to pay for each dyspepsia- ... "Economic consequences of near-patient test results - the case of tests for the Helicobacter Pylori bacterium in dyspepsia," ... Economic consequences of near-patient test results - the case of tests for the Helicobacter Pylori bacterium in dyspepsia. ...
Eradication of H. pylori would slightly decrease this patients chance of having persistent symptoms over the next three to 12 ... PYLORI FOR NONULCER DYSPEPSIA2. Background. H. pylori is the main cause of peptic ulcer disease. The role of H. pylori in ... H. pylori eradication therapy has a small but statistically significant effect for H. pylori positive nonulcer dyspepsia. An ... pylori eradication on dyspepsia symptoms and quality-of-life scores in patients with nonulcer dyspepsia. ...
Progresso significante na etiologia do câncer gástrico foi a identificação do Helicobacter pylori (H. pylori) e as evidências ... pylori na gênese da gastrite crônica. No entanto, a presença do H. pylori não apresentou associação de risco com GA e MI. Além ... pylori são mais patogênicas que outras. Vários estudos têm demonstrado que a infecção com H. pylori cag-A positivo é associada ... pylori. A idade é outro fator sabidamente associado à infecção pelo H. pylori e o desenvolvimento de lesões precursoras, porém ...
... pylori OR HP; dyspepsia OR functional dyspepsia OR non-ulcer dyspepsia; eradication OR cure OR treatment. The study outcome was ... Helicobacter pylori MeSH Terms expand_less. expand_more. Clarithromycin Continental Population Groups Dysbiosis Dyspepsia ... Is Helicobacter pylori Associated Functional Dyspepsia Correlated With Dysbiosis?. Kim YJ , Chung WC , Kim BW , Kim SS , Kim JI ... In the clinical setting, the most effective H. pylori eradication regimen for functional dyspepsia to provide relief of ...
Isolation of Helicobacter pylori from feces of patients with dyspepsia in the United Kingdom. Gastroenterology 1994;107(6):1671 ... Lack of effect of treating Helicobacter pylori infection in patients with non-ulcer dyspepsia. N Engl J Med 1998;339:1875-1881 ... Ugwuja, Emmanuel Ike and Ugwu, Nicholas Chukwuka (2007) Helicobacter pylori In Uninvestigated Dyspepsia In Primary Cares In ... Gastric accommodation in non-ulcer dyspepsia and the roles of Helicobacter pylori infection and vagal function. Gut 1999;44:55- ...
Dyspepsia , ERADICATE Hp2 - Treating Helicobacter Pylori With RHB-105 Compared to Active Comparator ... Eradication of H. pylori infection will be determined at Visit 5 based on 13C UBT testing conducted between 43 and 71 days ... ERADICATE Hp2 - Treating Helicobacter Pylori With RHB-105 Compared to Active Comparator Brief description of study. The "test ... This study will test the effectiveness of RHB-105, a new triple therapy to treat H. pylori infection in dyspeptic patients ...
... Javed Yakoob,. 1 Zaigham Abbas,1 Rustam ... Keywords: Dyspepsia, gastric biopsies, H. pylori, H. heilmannii, H. felis, coinfection, cats, dogs ... In this study we determined the prevalence of H. pylori and non-Helicobacter pylori organisms H. felis and H. heilmannii and ... pylori and 3(60%) coinfected with H. felis and H. pylori (p = 0.66). Intestinal metaplasia was observed in 3(3%)(p = 1.0) of ...
... pylori infection in dyspepsia remains controversial. This study aims to identify the prevalence of H. pylori and non-H. pylori ... pylori and non-H. pylori Helicobacter species. Chronic active inflammation was associated with H. pylori infection compared to ... Prevalence of non Helicobacter pylori species in patients presenting with dyspepsia. Javed Yakoob,. 1 Zaigham Abbas,1 Rustam ... Keywords: Dyspepsia, gastric biopsies, H. pylori, H. heilmannii, H. felis, coinfection, cats, dogs ...
Material and methods : Eighteen H. pylori -positive patients suffering from functional dyspepsia... ... pylori) in patients with functional dyspepsia affects gastric emptying (GE) and concomitantly relieves their clinical symptoms ... Aim : To study whether eradication of Helicobacter pylori (H. ... pylori) in patients with functional dyspepsia affects gastric ... Material and methods: Eighteen H. pylori-positive patients suffering from functional dyspepsia were recruited. At entrance and ...
Oral cavity is not a reservoir forHelicobacter pyloriin infected patients with functional dyspepsia. ... Thirty patients harbored H. pylori in the stomach, but it was not possible to detect H. pylori in any oral samples using P1/P2 ... Helicobacter pylori infection in the stomach was confirmed by a rapid urease test and urea breath tests. Samples of saliva, the ... Helicobacter pylori infection is very prevalent in Brazil, infecting almost 65% of the population. The aim of this study was to ...
An evidence-based approach to the management of uninvestigated dyspepsia in the era of Helicobacter pylori. Canadian dyspepsia ... Helicobacter pylori testing plus eradication was as effective and safe as prompt endoscopy for dyspepsia ... Helicobacter pylori testing plus eradication was as effective and safe as prompt endoscopy for dyspepsia ... QUESTION: Is Helicobacter pylori testing plus eradication as effective and safe as prompt endoscopy in patients with dyspepsia? ...
Helicobacter pylori testing plus eradication was as effective and safe as prompt endoscopy for dyspepsia ... Helicobacter pylori testing plus eradication was as effective and safe as prompt endoscopy for dyspepsia ... Helicobacter pylori testing plus eradication was as effective and safe as prompt endoscopy for dyspepsia ...
In patients with dyspepsia and a positive test result for Helicobacter pylori, is an H. pylori eradication strategy more ... In patients with dyspepsia and a positive test result for Helicobacter pylori, an H. pylori eradication strategy was more ... Treating Helicobacter pylori infection in primary care patients with uninvestigated dyspepsia: the Canadian adult dyspepsia ... Helicobacter pylori eradication vs placebo for uninvestigated dyspepsia at 1 year‡ Outcomes. Eradication. Placebo. RBI (95% CI) ...
Conclusion: In functional dyspepsia, H pylori treatment and cure of H pylori are no more effective for symptoms over six months ... Systematic review and economic evaluation of Helicobacter pylori eradication treatment for non-ulcer dyspepsia. Dyspepsia ... 1 The key question in the treatment of H pylori infected patients with functional dyspepsia is whether cure of H pylori ... Helicobacter pylori eradication treatment does not benefit patients with nonulcer dyspepsia. Am J Gastroenterol2001; 96:2329-36 ...
The aim of this study was to report for the first time the incidence of H. pylori infection among patients with dyspepsia ... Relationship between ABO Blood Groups and Helicobacter Pylori Infection among Patients with Dyspepsia. Journal of Virology and ... The distribution of ABO blood groups and H. pylori infection demonstrated that positivity rate of H. pylori was 88.9 % in blood ... According to gender, 84.5% males and 58.9% females were H. pylori positive. The frequencies of H.pylori infection among ...
H-pylori, dyspepsia, dyspepsia management, Bioengineering, Gastroenterology. Subjects:. Technology , Engineering (General). ... Primary care physicians views on H-pylori in dyspepsia management and use of a locally available 13-carbon urea breath test ... This paper discusses Primary care physicians views on H-pylori in dyspepsia management and use of a locally available 13- ... views on H-pylori in dyspepsia management and use of a locally available 13-carbon urea breath test. Gastroenterology, 114 ( ...
The role of Helicobacter pylori infection in functional dyspepsia URI: https://www.openarchives.gr/aggregator-openarchives/edm/ ...
Șincu, NI., Chiriac, L.C., Zaharia-Kézdi, E.I. et al. Helicobacter pylori - HIV co-infection and dyspepsia. BMC Infect Dis 14, ... Helicobacter pylori infection is one of the most frequent causes of dyspepsia in the general population. As gastro-intestinal ... the absence of a statistically significant association between Helicobacter pylori infection and dyspepsia among HIV-positive ... We compared the two groups from the point of view of the frequency of Helicobacter pylori infection. Statistical analysis of ...
The response of Asian patients with functional dyspepsia to eradication of Helicobacter pylori infection. ... The response of Asian patients with functional dyspepsia to eradication of Helicobacter pylori infection. European Journal of ...
  • Randomized trial of endoscopy with testing for Helicobacter pylori compared with non-invasive H. pylori testing alone in the management of dyspepsia. (cogprints.org)
  • NICE Quality Standard 96 (QS96) for investigation and management of dyspepsia and GORD in adults was published in July 2015. (guidelinesinpractice.co.uk)
  • NICE QS96 contains guidance on the investigation and management of dyspepsia and GORD, including in the context of their role as a risk factor for oesophagogastric cancer. (guidelinesinpractice.co.uk)
  • 1.2.5 Encourage people who need long-term management of dyspepsia symptoms to reduce their use of prescribed medication stepwise: by using the effective lowest dose, by trying 'as-needed' use when appropriate, and by returning to self-treatment with antacid and/or alginate therapy (unless there is an underlying condition or comedication that needs continuing treatment). (nice.org.uk)
  • 1.5.1 Offer people who need long-term management of dyspepsia symptoms an annual review of their condition, and encourage them to try stepping down or stopping treatment (unless there is an underlying condition or comedication that needs continuing treatment). (nice.org.uk)
  • Management of Dyspepsia. (nih.gov)
  • Optimum management of dyspepsia in primary care is a debatable subject. (biomedcentral.com)
  • Helicobacter pylori test and treat versus proton pump inhibitor in initial management of dyspepsia in primary care: multicentre randomised controlled trial (MRC-CUBE trial). (nihr.ac.uk)
  • CONCLUSIONS: Test and treat and acid suppression are equally cost effective in the initial management of dyspepsia. (nihr.ac.uk)
  • 294 patients (mean age 49 y, 50% men) who were ≥ 18 years of age and had uninvestigated symptoms of dyspepsia for ≥ 3 months. (acpjc.org)
  • The aim of grouping the symptoms of dyspepsia is to try to match symptoms to pathophysiological disturbances to enable rational prescribing. (bmj.com)
  • Three of these 12 trials, involving 2,541 patients, evaluated the effect of H. pylori eradication treatment in patients with symptoms of dyspepsia, defining dyspepsia cure as no symptoms or mild symptoms not interfering with daily activities. (aafp.org)
  • These recommendations apply to adults (aged 18 and over) with symptoms of dyspepsia, symptoms suggestive of gastro-oesophageal reflux disease (GORD), or both. (nice.org.uk)
  • 1.1.1 Community pharmacists should offer initial and ongoing help for people with symptoms of dyspepsia. (nice.org.uk)
  • Patients who arrived at the outpatient Gastroenterology Clinic of the Rift Valley Hospital in Nakuru, Kenya, with uninvestigated symptoms of dyspepsia for at least the previous 3 months were included in the study. (cdc.gov)
  • Helicobacter pylori infection and gastric emptying in cirrhotic patients with symptoms of dyspepsia. (unboundmedicine.com)
  • There are several causes of dyspepsia including peptic ulcer disease. (ndtv.com)
  • Helicobacter pylori infection is one of the most frequent causes of dyspepsia in the general population. (biomedcentral.com)
  • They recommend the first diagnostic approach to exclude structural causes of dyspepsia presumed to be originating in the gastroduodenal region with upper gastrointestinal endoscopy. (jnmjournal.org)
  • Many causes of dyspepsia exist, including Helicobacter pylori . (cdc.gov)
  • Most other patients should undergo upper endoscopy to rule out malignancy and other serious causes of dyspepsia. (aafp.org)
  • H. pylori infection first causes chronic non atrophic gastritis. (scielo.br)
  • In patients with nonulcer dyspepsia, eradication of Helicobacter pylori with omeprazole and antibiotics did not relieve symptoms but led to increased recovery from gastritis. (acponline.org)
  • In H. pylori-positive patients (36.7% of all patients), smokers were more prevalent than non-smokers in the development of intestinal metaplasia (20% versus 0%, p = 0.003), erosive gastritis (80% versus 30%, p = 0.00), glandular atrophy (20% versus 0%, p = 0.003) and reactive gastropathy (20% versus 0%, p = 0.003). (scirp.org)
  • Conclusions: This study revealed that smoking may increase the prevalence of having gastric intestinal metaplasia, erosive gastritis, glandular atrophy and reactive gastropathy in H. pylori-positive Egyptian patients. (scirp.org)
  • Chronic H . infection Pylori activates the immune response of the host, induces active chronic inflammation and damage to the mucosa, giving rise to multifocal atrophic gastritis, glandular dysplasia, intestinal metaplasia and adenocarcinoma [13]. (scirp.org)
  • Similarly, in an evaluation of patients with dyspeptic symptoms and chronic superficial antral gastritis, Testoni and colleagues found no correlation between the presence of H pylori and specific symptom complaints or worsening dyspeptic symptoms. (levelofhealth.com)
  • A new classification for gastritis, the Sydney System, including H. pylori gastritis, was proposed in 1990. (springer.com)
  • Aetna considers testing of H. pylori infection for the management of autoimmune gastritis experimental and investigational because of insufficient evidence of its effectiveness. (aetna.com)
  • H. pylori infection did not show risk for occurrence of atrophic gastritis and intestinal metaplasia, suggesting that other risk factors should be involved in the carcinogenesis process. (qxmd.com)
  • Atrophic gastritis and intestinal metaplasia in Helicobacter pylori infection: the role of CagA status. (qxmd.com)
  • Association of Helicobacter pylori infection with atrophic gastritis and intestinal metaplasia. (qxmd.com)
  • Is there any relationship between functional dyspepsia and chronic gastritis associated with Helicobacter pylori infection? (qxmd.com)
  • Gastritis, also called dyspepsia, is an inflammation of the lining of the stomach. (clevelandclinic.org)
  • Gastritis (also called dyspepsia) is an inflammation (swelling and irritation) of the lining of the stomach. (clevelandclinic.org)
  • This finding has led researchers to postulate that H. pylori does not play a major role in the etiologic findings of upper gastrointestinal system pathology apart, from gastritis ( 7 , 8 ). (cdc.gov)
  • Repositorio da Producao Cientifica e Intelectual da Unicamp: Chronic Gastritis Associated To Helicobacter Pylori In Patients With Non-ulcerating Dyspepsia And With Duodenal Ulcer [gastrite Crônica Associada Ao "helicobacter Pylori" Em Pacientes Com Dispepsia Não Ulcerosa E Com úlcera Duodenal. (unicamp.br)
  • PURPOSE: Prevalence of chronic gastritis and infection of the gastric mucosa by Helicobacter pylori in patients with non-ulcerating dyspepsia and duodenal ulcer. (unicamp.br)
  • Chronic gastritis of the gastric body with presence of H. pylori in the histopathological examination was found in 10 out of 13 patients. (unicamp.br)
  • Helicobacter pylori (H. pylori), a gram-negative micro-aerophilic bacillus, is recognized to be associated with diverse upper gastrointestinal pathologies such as chronic gastritis, peptic ulceration, mucosal associated lymphoid tissue (MALT) lymphoma and gastric carcinoma ( 1 , 2 ). (ispub.com)
  • However, no association between H. pylori seropositivity and BMI, metabolic diseases (type 2 diabetes, hypertension and dyslipidemia, gout or increased uric acid) and gastrointestinal diseases (gastritis, inflammatory bowel disease, and gastric or duodenal ulcer) was observed. (frontiersin.org)
  • Dyspepsia is a common problem and is frequently caused by gastroesophageal reflux disease (GERD) or gastritis. (wikipedia.org)
  • When dyspepsia can be attributed to a specific cause, the majority of cases concern gastroesophageal reflux disease (GERD) and gastritis disease. (wikipedia.org)
  • H. pylori infection was diagnosed prospectively in 246 untreated dyspeptic patients who underwent upper gastrointestinal endoscopy. (hindawi.com)
  • To estimate the prevalence of H. pylori infection and the precancerous gastric lesions and their relationship, in patients with dyspeptic symptoms who underwent upper gastrointestinal endoscopy at a reference center in the central region of Rio Grande do Sul state, Brazil. (scielo.br)
  • We analyzed gastric biopsies taken from corpus and antrum of patients who underwent upper gastrointestinal endoscopy for H. pylori detection, between 1994 and 2003. (scielo.br)
  • Upper gastrointestinal endoscopy is regarded as the investigation of choice in patients with upper gastrointestinal disorders which often present with dyspepsia. (ispub.com)
  • Exclusion criteria included gastroesophageal reflux disease, upper gastrointestinal investigation in the previous 6 months or ≥ 2 times in the past 10 years, eradication therapy for H. pylori in the past 6 months, previous gastric surgery, ulcer disease or endoscopic esophagitis, and the irritable bowel syndrome. (acpjc.org)
  • This study aimed to assess the epidemiology and the endoscopic findings in relation to H pylori infection of uninvestigated dyspepsia, among patients attending gastroenterology in Al-Sadder Teaching Hospital in Misan province, South of Iraq. (ommegaonline.org)
  • H. pylori eradication is associated with a higher and faster healing rate of ulcerous lesions caused by endoscopic submucosal dissection. (qxmd.com)
  • In patients undergoing endoscopic submucosal dissection for early gastric cancer, H. pylori eradication decreases the incidence of metachronous tumors. (qxmd.com)
  • Narrow-band imaging allows visualization of the mucous and vascular pattern in H. pylori-infected patients during the endoscopic examination. (qxmd.com)
  • The authors conclude that patients with dyspepsia and normal endoscopic results gain a modest benefit from eradication of H. pylori infection and it may be cost effective, but further evidence is needed of the decision makers' willingness to pay for the relief of dyspepsia. (aafp.org)
  • After through endoscopic evaluation, gastric mucosal biopsies were taken from all patients for investigation of H. pylori (Rapid urease test (R.U.T), direct exam and IgG Anti H. pylori tests) and histological assessment. (emedicalj.com)
  • This work aimed to determine the different endoscopic and histological changes in gastric mucosa promoted by smoking among H . pylori -positive and H . pylori -negative Egyptian patients with dyspepsia. (scirp.org)
  • A cross-sectional study was conducted among two hundred forty consecutive patients who presented with dyspepsia symptoms and had been attending endoscopic units of the Tropical Medicine Department at Zagazig University Hospital, Egypt and Tanta University Hospital, Egypt between August 2019 and March 2020. (scirp.org)
  • Confirmation of the presence of the H. pylori bacterium can be determined non-invasively using an FDA-cleared urea breath test or a stool antigen test or invasively on endoscopic biopsy followed by rapid urease testing (CLOtest ™ , PyloriTek ™ , Hpfast ™ ), histology with special stains, or culture. (aetna.com)
  • Objectives: To study the prevalence of H pylori among patients referred to endoscopic unit Complaining from epigastric pain and dyspepsia. (sjomr.org)
  • Methods: To study the epidemiology of H pylori infection in patients suffering from epigastric pain and dyspepsia referred to endoscopic unit between first of January to 31 of July 2013. (sjomr.org)
  • INTERVENTIONS: Eight endoscopic biopsies (4 of the body and 4 of the gastric antrum) were performed on each of the patients to identify H. pylori, using three tests: urease, gram and histopathological examination. (unicamp.br)
  • Several reports have indicated that screening for H pylori may avoid subsequent endoscopic examination. (nih.gov)
  • H. pylori infection can be diagnosed by non-invasive methods or by endoscopic biopsy of the gastric mucosa. (ispub.com)
  • Although dyspepsia has many possible causes, the primary causes are peptic ulcer disease, gastro-oesophageal reflux disease, and functional (non-ulcer dyspepsia). (bmj.com)
  • 2 People with heartburn or acid regurgitation alone and those in whom reflux symptoms are dominant and epigastric pain or discomfort is minor should probably not be classed as having dyspepsia but as having symptomatic gastro-oesophageal reflux disease. (bmj.com)
  • Dyspepsia and gastro-oesophageal reflux disease in adults: investigation and management. (guidelinesinpractice.co.uk)
  • To perform a systematic review of the literature to determine whether chronic infection with H pylori is relevant to nonulcer or uninvestigated dyspepsia. (nih.gov)
  • Dyspepsia is usually a chronic condition in primary and secondary care. (scirp.org)
  • Chronic active inflammation was observed in 53(56%) (p = 0.001) of the patients with H. pylori infection alone as compared to 3(37%) (p = 0.73) coinfected with H. heilmannii and H. pylori and 3(60%) coinfected with H. felis and H. pylori (p = 0.66). (pubmedcentralcanada.ca)
  • A total of 181 H pylori positive patients with chronic functional dyspepsia who had not responded to a one week antacid run-in and two week double blind antisecretory or placebo treatment were included. (bmj.com)
  • Broad (and vague) definitions of dyspepsia have been proposed, 1 but a current internationally accepted definition of dyspepsia is chronic or recurrent pain or discomfort centred on the upper abdomen. (bmj.com)
  • Dyspepsia is a complex condition, including upper gastrointestinal tract with chronic and recurrent symptoms, including epigastric pain, discomfort, postprandial fullness and satiety. (ommegaonline.org)
  • Functional dyspepsia is a clinical syndrome characterized by chronic or recurrent upper abdominal pain or discomfort, in the absence of underlying organic disease to explain the symptoms [ 1 ]. (omicsonline.org)
  • Functional dyspepsia tends to be a rather common, chronic condition, which, with the ever-increasing cost of drugs, poses a constant challenge to the treating physician [ 4 , 5 ]. (omicsonline.org)
  • Helicobacter pylori eradication seems to have a different effect in chronic and naive NSAID users. (tripdatabase.com)
  • Aetna considers testing of tonsillar H. pylori colonization for the management of chronic tonsillitis experimental and investigational because of insufficient evidence of its effectiveness. (aetna.com)
  • Chronic use of NSAIDs in patients with H. pylori infection increases the risk of PUD. (aafp.org)
  • Chronic gastric Helicobacter pylori infection is common in patients with dyspeptic symptoms. (unboundmedicine.com)
  • Dyspepsia is described as chronic or recurrent pain or discomfort in the upper abdomen. (biomedcentral.com)
  • Gastroenteritis increases the risk of developing chronic dyspepsia. (wikipedia.org)
  • This is the most common cause of chronic dyspepsia. (wikipedia.org)
  • This study was designed to compare the accuracy of three different invasive methods for the detection of Helicobacter pylori (H. pylori) infection in patients with dyspepsia. (hindawi.com)
  • Antral biopsy histology and culture are the best methods for the diagnosis of H. pylori infection in our cohort of patients with dyspepsia. (hindawi.com)
  • Several methods have been developed for the detection of H. pylori infection. (hindawi.com)
  • These methods include noninvasive tests that are based on the detection of antibodies to H. pylori or the urea breath test (UBT) or invasive tests that require endoscopy to obtain tissue biopsies, such as the rapid urease test (RUT), culture, and histological examination [ 7 - 9 ]. (hindawi.com)
  • Comparison of biopsy-based methods for the detection of Helicobacter pylori infection. (cogprints.org)
  • For Helicobacter pylori infection in the setting of dyspepsia, diagnostic options include serologic tests, a stool antigen test, a urea breath test, and invasive methods, such as endoscopy with biopsy. (biomedcentral.com)
  • Patients and Methods: A cross-sectional study was conducted among 240 consecutive patients with dyspepsia who underwent upper endoscopy and histopathological examination of gastric biopsies at Zagazig and Tanta University Hospital with H. pylori-positivity assessment by stool antigen and rapid urease test. (scirp.org)
  • This book presents the current state of knowledge regarding the ability of Helicobacter pylori to colonize the gastrointestinal tract, the global epidemiology of H. pylori infection, transmission routes, the pathophysiology of H. pylori -related gastroduodenal and other diseases, diagnosis and treatment methods, guidelines for eradication, antibiotic resistance, the reinfection rate after H. pylori eradication, and animal models of H. pylori or related Helicobacter infection. (springer.com)
  • The aim is to equip readers around the world with the understanding required in order to implement effective methods of H. pylori eradication and to enhance clinical outcomes for patients. (springer.com)
  • Aetna considers simultaneous urea breath testing and stool antigen testing for H. pylori not medically necessary because concurrent testing with both methods is not necessary. (aetna.com)
  • Although none of the asymptomatic patients in our study was diagnosed with Helicobacter pylori , the absence of a statistically significant association between Helicobacter pylori infection and dyspepsia among HIV-positive patients may suggest that other etiologies should be searched in HIV-infected patients with gastro-intestinal complaints. (biomedcentral.com)
  • Among adults, the association between H. pylori infection and dyspepsia remained after adjusting for the above factors and for educational attainment, family size, and manual occupation. (cdc.gov)
  • The aim of our case-control study was to investigate the association between H. pylori infection and dyspepsia in Nakuru, Kenya. (cdc.gov)
  • As the eradication of H. pylori has been shown to improve the outcome of peptic ulcer disease in terms of recurrence and complications, the accurate diagnosis of H. pylori infection is of clinical importance. (hindawi.com)
  • Studies on biopsy sites for the diagnosis of H. pylori infection are sometimes conflicting. (hindawi.com)
  • So far no optimal biopsy site for the diagnosis of H. pylori status has been currently established. (hindawi.com)
  • This study has been designed and undertaken to compare the sensitivity, specificity, and accuracy of different invasive tests and biopsy sites for the diagnosis of H. pylori infection in clinical practice. (hindawi.com)
  • Is a diagnosis of organic dyspepsia reliable without an endoscopy? (bmj.com)
  • Aetna considers testing for anti- Helicobacter pylori IgG in urine for diagnosis of H. pylori infection experimental and investigational because of insufficient evidence of its effectiveness. (aetna.com)
  • Diagnosis of H.pylori infection both by invasively by endoscopy and biopsy or noninvasively by serologic analysis, and breath test. (issuu.com)
  • In 60% of the investigated patients, results of tests to rule out peptic ulcer disease, gastro-esophageal reflux disease, and gastric cancer are normal, and the diagnosis is functional dyspepsia ( 2 ). (cdc.gov)
  • They fulfill Rome III clinical criteria for the diagnosis of functional dyspepsia with no organic disease at endoscopy. (scielo.br)
  • As the patient in the case study was fairly young, the likelihood that no specific pathological condition would be discovered (ie, the diagnosis will be nonulcer dyspepsia) was relatively high. (nursinginpractice.com)
  • In this case, dyspepsia is referred to as non-ulcer dyspepsia and its diagnosis is established by the presence of epigastralgia for at least 6 months, in the absence of any other cause explaining the symptoms. (wikipedia.org)
  • The aim of this study was to evaluate the presence of this bacterium in the oral cavity of patients with functional dyspepsia (epigastric pain syndrome), establish the main sites of infection in the mouth, and assess the frequency of cagA and vacA genotypes of oral H. pylori. (ovid.com)
  • BackgroundThe cytotoxin associated gene A cagA, and the vacuolating cytotoxin gene A vacA of Helicobacter pylori have been associated to phenotypic characteristics of virulence. (duhnnae.com)
  • The objectives of this study were to detect the presence of cagA and to characterize the allelic variants of vacA in 63 strains of H. pylori isolated from colonized individuals with different clinical outcomes. (duhnnae.com)
  • Prevalence rate of H. pylori was 66.3% and virulence factor CagA was detected in nearly 43% of positive samples. (scielo.br)
  • For patients who had negative results on H pylori testing, those who had previously used NSAIDs had endoscopy, and those who had reflux symptoms but were not using NSAIDs were treated with a proton pump inhibitor (PPI). (bmj.com)
  • We therefore compared the cost-effectiveness of some of the most common noninvasive testing strategies for H. pylori along with empiric proton pump inhibitor (PPI) trial in the management of uninvestigated dyspepsia. (biomedcentral.com)
  • Adults with dyspepsia or reflux symptoms have a 2-week washout period before a test for Helicobacter pylori if they are receiving proton pump inhibitor therapy. (guidelinesinpractice.co.uk)
  • 1.4.2 Leave a 2‑week washout period after proton pump inhibitor (PPI) use before testing for Helicobacter pylori (hereafter referred to as H pylori ) with a breath test or a stool antigen test. (nice.org.uk)
  • dyspepsia patients ended to remain symptomatic with 61% using drugs and 43% having gastrointestinal procedures, indicating intensive use of medical resources [2]. (scirp.org)
  • The most common cause of upper gastrointestinal symptoms is nonulcer dyspepsia, yet the pathophysiology of this condition has been poorly characterized, and the optimal treatment is uncertain. (aafp.org)
  • Relationship between Helicobacter pylori infection and gastrointestinal symptoms and syndromes. (cogprints.org)
  • 12. Nijevitch AA, Scherbakov PL. Helicobacter pylori and gastrointestinal symptoms in school children in Russia. (cogprints.org)
  • The aim of this study was the detection of H. pylori infection in patients with various gastrointestinal symptoms as related to blood groups and Rhesus factor. (ibimapublishing.com)
  • The aim of this study was to report for the first time the incidence of H. pylori infection among patients with dyspepsia symptoms, and to determine the relationship between the ABO blood groups and H.pylori infection in patients with various gastrointestinal symptoms, from Basrah-Iraq. (ibimapublishing.com)
  • Because structural Upper Gastrointestinal (UGI) tract diseases, such as peptic ulcer, erosive esophagitis, luminal strictures and malignancy can course with dyspepsia, Esopha Gogastroduodenoscopy (EGD) is the diagnostic procedure of choice to differentiate patients with organic from those with functional dyspepsia. (ommegaonline.org)
  • Dyspepsia, characterized by pain and discomfort centred in the upper abdomen, is a common gastrointestinal complaint, with an annual prevalence of up to 40% in Western countries. (levelofhealth.com)
  • 1.3.1 For people presenting with dyspepsia together with significant acute gastrointestinal bleeding, refer them immediately (on the same day) to a specialist. (nice.org.uk)
  • Hence, it is often difficult to distinguish between dyspepsia and GORD in the uninvestigated patient who presents with upper gastrointestinal symptoms in primary care. (biomedcentral.com)
  • Recently, a great variety of studies aimed to investigate and even suggestHelicobacter pylori as an important key factor in gastrointestinal and non-gastrointestinal events development. (scielo.br)
  • The initial management of a stable patient with dyspepsia differs from the management of an unstable patient with upper gastrointestinal (GI) hemorrhage. (medscape.com)
  • Dyspepsia, indigestion and heartburn are broad terms often used by patients to describe pain or discomfort that arises in the upper gastrointestinal tract. (nursinginpractice.com)
  • To determine the types of upper gastrointestinal lesions and the frequency of helicobacter pylori among dyspeptic patients in Maiduguri, Nigeria. (ispub.com)
  • The aim of this study is to determine the common upper gastrointestinal lesions and the frequency of H. pylori among dyspeptic patients seen at the University of Maiduguri Teaching Hospital. (ispub.com)
  • A potential risk for severe gastrointestinal diseases including gastric cancer in persons infected with H. pylori is known ( 2 - 5 ). (frontiersin.org)
  • EDITOR-Jaakkimainen et al's meta-analysis concludes that an improvement in dyspeptic symptoms occurred among patients with non-ulcer dyspepsia in whom Helicobacter pylori was eradicated. (bmj.com)
  • At entrance and two weeks after successful H. pylori eradication they filled in a questionnaire examining the intensity of dyspeptic symptoms and underwent measurement of GE of a 378 kcal solid test meal labelled with 75 μl of 13 C-octanoic acid. (termedia.pl)
  • Considering the whole patient group, the H. pylori eradication did not significantly affect the dyspeptic symptoms. (termedia.pl)
  • Another recent randomised trial showed that non-invasive H pylori testing and treatment was superior to and more cost effective than placebo in improving uninvestigated dyspeptic symptoms. (bmj.com)
  • Previous studies on the treatment of Helicobacter pylori infection in functional dyspepsia have shown little, if any, effect on dyspeptic symptoms. (bmj.com)
  • H pylori treatment and cure of H pylori infection had no effect on complete resolution of all dyspeptic symptoms, individual symptoms, or various aspects of quality of life. (bmj.com)
  • 1 The key question in the treatment of H pylori infected patients with functional dyspepsia is whether cure of H pylori infection improves dyspeptic symptoms. (bmj.com)
  • 4 (11.11%) HIV-positive patients with dyspeptic symptoms tested positive for Helicobacter pylori infection, while none of the patients in group B was diagnosed with Helicobacter pylori infection (p=1.0000, OR=1.523). (biomedcentral.com)
  • 1 2 3 4 These plans have been based on the dyspepsia subgroups or on individual (predominant) dyspeptic symptoms. (bmj.com)
  • H. Pylori infection would be defined by the presence of dyspeptic symptoms with detection of the bacterium on histopathology. (sciepub.com)
  • 348 patients who sought medical care for dyspeptic symptoms (pain or discomfort in the upper abdomen) that had persisted for ≥ 6 months, had no history of peptic ulcer disease or gastroesophageal disease, and tested positive for H. pylori . (acponline.org)
  • However, heartburn, which had been included as a symptom of dyspepsia in the past, was excluded from symptom constellation of dyspepsia, although it may coexist with dyspeptic symptoms. (jnmjournal.org)
  • For example, if a patient continues to complain of dyspeptic symptoms after complete healing of peptic ulcer diseases either by stopping non-steroidal anti-inflammatory drugs (NSAIDs) or by eradicating Helicobacter pylori , should they be excluded as having functional dyspepsia? (jnmjournal.org)
  • Acupuncture efficaciously improves dyspeptic symptoms in patients with refractory functional dyspepsia. (greenmedinfo.com)
  • Confirm eradication of Helicobacter pylori after therapy in patients with H. pylori -associated ulcer, continued dyspeptic symptoms, mucosa-associated lymphoid tissue lymphoma, and resection of gastric cancer. (aafp.org)
  • The effect of H. pylori infection on gastric emptying, in cirrhotic patients with dyspeptic symptoms, has never been studied. (unboundmedicine.com)
  • MAIN OUTCOME MEASURES: Cost effectiveness in cost per quality adjusted life year (QALY) (EQ-5D) and effect on dyspeptic symptoms at one year measured with short form Leeds dyspepsia questionnaire. (nihr.ac.uk)
  • In the clinical setting, the most effective H. pylori eradication regimen for functional dyspepsia to provide relief of symptoms is a metronidazole-based treatment regimen for at least 10 days. (koreamed.org)
  • 1. Calam J. Clinical science of Helicobacter pylori infection: ulcers and NSAIDs. (cogprints.org)
  • Helicobacter pylori: prevalence of antimicrobial resistance in clinical isolates. (cogprints.org)
  • To study whether eradication of Helicobacter pylori (H. pylori) in patients with functional dyspepsia affects gastric emptying (GE) and concomitantly relieves their clinical symptoms. (termedia.pl)
  • During the past decade dyspepsia has been divided into clinical subgroups based on medical history: ulcer-like (typical ulcer symptoms), dysmotility-like (symptoms suggestive of gastric stasis), reflux-like (retrosternal and concomitant upper abdominal symptoms), and unspecified (symptoms cannot be classified) (box). (bmj.com)
  • Functional dyspepsia is a clinical syndrome in which there is an absence of underlying organic disease to explain the symptoms. (omicsonline.org)
  • Demographic and clinical examinations were fulfilled and basal serum gastrin and CCK level and IgG anti H. pylori were measured. (emedicalj.com)
  • Functional dyspepsia: relationship between clinical subgroups and Helicobacter pylori status in Western Turkey. (acibadem.edu.tr)
  • This book will be a great asset in clinical practice for all practitioners who are involved in caring for patients with H. pylori -related diseases or have an interest in the subject. (springer.com)
  • Since 1982, when Helicobacter pylori was discovered, gastroduodenal disease have been completely revised as a con- sequence of the results of basic and clinical research in this field. (springer.com)
  • As concerns the clinical approach to peptic ulcer disease in the 1990's, the majority of authors agree on the importance of H. pylori eradication. (springer.com)
  • Moreover, recent clinical studies suggest that H. pylori infection can be associated with other gastroduodenal diseases, such as non ulcer dyspepsia and gastric cancer. (springer.com)
  • Dyspepsia in the control group was excluded by clinical interview and a structured screening questionnaire. (cdc.gov)
  • TYPE OF STUDY, SITE, PATIENTS: A prospective study was made of 48 consecutive patients with non-ulcerating dyspepsia of the dismotility type (NUD), and 13 consecutive patients with duodenal ulcer in activity (DU), selected from the gastroenterology outpatient clinic of the Clinical Hospital of the State University of Campinas (Unicamp). (unicamp.br)
  • Dyspepsia is a common presenting complaint in clinical practice. (ispub.com)
  • In most cases, the clinical history is of limited use in distinguishing between organic causes and functional dyspepsia. (wikipedia.org)
  • A large systematic review of the literature was recently performed to evaluate the effectiveness of diagnosing organic dyspepsia by clinical opinion versus computer models in patients referred for upper endoscopy. (wikipedia.org)
  • Functional dyspepsia (FD) is defined, according to the Rome III criteria, such as abdominal discomfort or epigastric pain‚ no evidence of structural disease (including at upper endoscopy) that is likely to explain the symptoms. (scirp.org)
  • This is a, randomized, double blind, active comparator-controlled study of RHB-105 in adult subjects complaining of epigastric discomfort that have been screened and found to be positive for H. pylori infection via 13C UBT and gastric biopsy. (centerwatch.com)
  • The oral cavity may not be a reservoir for H. pylori in patients with epigastric pain syndrome, the bacterium being detected exclusively in the stomach. (ovid.com)
  • Dyspepsia was defined as a complex of epigastric pain including heartburn, acid regurgitation, excessive burping or belching, increased abdominal bloating, nausea, abnormal or slow digestion, or early satiety. (acpjc.org)
  • Dyspepsia is predominant pain or discomfort in the upper abdomen and the patients must also have one or more of the following four symptoms: postprandial fullness, early satiation, epigastralgia and epigastric burning. (ommegaonline.org)
  • Conclusion: In conclusion there is a significant relation between H pylori and epigastric pain & dyspepsia H pylori infection affect different age group. (sjomr.org)
  • 1.4.1 Be aware that dyspepsia in unselected people in primary care is defined broadly to include people with recurrent epigastric pain, heartburn or acid regurgitation, with or without bloating, nausea or vomiting. (nice.org.uk)
  • Dyspepsia is characterized by epigastric pain, discomfort, or a burning sensation. (aafp.org)
  • All patients had to have positive test results for H. pylori on the Helisal rapid blood test and the 13 C urea breath test. (acpjc.org)
  • The American Gastroenterological Association (AGA) in 2005 recommended that to diagnose Helicobacter pylori infection in patients with dyspepsia, physicians should use either the stool antigen test or the urea breath test. (biomedcentral.com)
  • A solid-phase gastric emptying study and 14C urea breath test were performed in 80 cirrhotic patients with dyspepsia. (unboundmedicine.com)
  • In a community survey, a diagnostic 13 C-urea breath test for H. pylori was performed on 302 volunteers that were not taking antibiotics, antacids, or proton pump inhibitors one month prior to the test. (revistagastroenterologiamexico.org)
  • A total of 98 patients completed Modified Glasgow Dyspepsia Severity Score Questionnaire (MGDSSQ) at initial presentation before undergoing the 13 Carbon Urea Breath Test (UBT) for HP. (biomedcentral.com)
  • General practitioners' habits and knowledge in relation to the management of H. pylori-associated dyspepsia and their views about a locally available 13-carbon urea breath test. (bjgp.org)
  • Documentation of H pylori cure with a noninvasive test, such as the urea breath test or fecal antigen test, is appropriate in patients with complicated ulcers. (medscape.com)
  • Randomised controlled trial of Helicobacter pylori testing and endoscopy for dyspepsia in primary care. (nihr.ac.uk)
  • The 2017 American College of Gastroenterology (ACG) guidelines for the treatment of H pylori infection (HPI) indicates that selection of an HPI management regimen should take into account any previous antibiotic exposure(s). (medscape.com)
  • Three hundred and thirty patients with dyspepsia referred to the gastroenterology unit for endoscopy were recruited. (ispub.com)
  • According to high frequency of H. pylori in NUD patients, the investigation of patients for the presence of H. pylori in patients is recommended. (emedicalj.com)
  • however, this incidence rate is similar to that of the general population, and attempts at linking the presence of H pylori with a specific symptom profile have proved to be inconclusive. (levelofhealth.com)
  • A prospective case control study was conducted in 50 patients with non-ulcer dyspepsia (NUD) and 10 age and sex matched controls to determine the prevalence of Helicobacter pylori in patients with NUD and to correlate symptoms, histology and presence of H pylori in gastric biopsies. (who.int)
  • The presence of H.pylori increases peptic ulcer disease and gastric cancer [3, 4], but decreases the risk of esophageal reflux and its consequences, and may protect against childhood asthma and related disorders [5, 6]. (issuu.com)
  • The presence of H. pylori in the gastric mucosa of all patients with DU agrees with studies already published. (unicamp.br)
  • The objective of this study was to evaluate the presence of H. pylori, bacterial virulence and C-reactive protein serum levels in individuals diagnosed with functional dyspepsia. (scielo.br)
  • A modified Giemsa stain was employed to demonstrate the presence of H. pylori. (ispub.com)
  • The question of management then turns on the relative costs and effectiveness of endoscopy, noninvasive tests, and eradication of H. pylori and empiric acid suppression ( 1 ). (acpjc.org)
  • Initial assessment of dyspepsia often includes noninvasive testing for Helicobacter pylori infection. (biomedcentral.com)
  • Although there is extensive literature on the cost-effectiveness of H. pylori treatment, there is little information comparing the cost-effectiveness of various currently used, noninvasive testing strategies. (biomedcentral.com)
  • Under our assumptions for how testing for H. pylori infection is employed in United States medical practice, the available noninvasive tests all have similar cost-effectiveness between one another as well as with empiric PPI trial. (biomedcentral.com)
  • 44 ] Given that "test and treat" using noninvasive tests is a common approach to uninvestigated dyspepsia in the United States, the specific noninvasive test strategy becomes a key decision point. (biomedcentral.com)
  • 85% and previously were considered the noninvasive tests of choice for initial documentation of H. pylori infection. (tripdatabase.com)
  • 50 years of age without severe symptoms with a noninvasive test for H. pylori, and then treat those with positive results with H. pylori -eradicating drugs ( 5 ). (cdc.gov)
  • Thus, a noninvasive H. pylori test-and-treat strategy in a primary care setting in an economically depressed area, such as Africa, should be based on data that show an association between dyspepsia and H. pylori infection. (cdc.gov)
  • In addition, for conditions such as peptic ulcers and gastric cancers, dyspepsia is frequently the first warning sign [5]. (scirp.org)
  • If H. pylori is causing peptic ulcers that result in indigestion, an antibiotic will be prescribed. (medicalnewstoday.com)
  • Methods38 strains were isolated from patients with non-ulcerative dyspepsia NUD and 25 were isolated from colonized individuals with peptic ulcers. (duhnnae.com)
  • Treating Helicobacter pylori infection in primary care patients with uninvestigated dyspepsia: the Canadian adult dyspepsia empiric treatment- Helicobacter pylori positive (CADET- Hp ) randomised controlled trial. (acpjc.org)
  • Treatment options include empiric antisecretory therapy, empiric triple therapy for H pylori infection, endoscopy followed by appropriate therapy based on findings, and H pylori serology followed by triple therapy for patients who are infected. (medscape.com)
  • Therefore, it is the clinician's challenging task to separate patients who may have an organic disorder, and thus warrant further diagnostic testing, from patients who have functional dyspepsia, who are given empiric symptomatic treatment. (wikipedia.org)
  • Blood samples were tested for H.pylori antibodies by RDT, and subjected to ABO/Rhesus blood group antigen typing. (ibimapublishing.com)
  • We performed a retrospective, case-control study on two groups of HIV-infected patients admitted to the Infectious Diseases Clinic I, Tîrgu-Mureş and tested for Helicobacter pylori infection by stool antigen detection: group A - 36 dyspeptic subjects and group B - 5 patients without dyspeptic complaints. (biomedcentral.com)
  • What symptomatic treatments are effective for nonulcer dyspepsia? (aafp.org)
  • To assess the long-term effect of Helicobacter pylori eradication on symptomatic improvement according to the type of antibiotic and the duration of treatment in H. pylori-associated functional dyspepsia. (koreamed.org)
  • The study outcome was the summary odds ratio (OR) for symptomatic improvement in H. pylori-associated functional dyspepsia with successful eradication therapy. (koreamed.org)
  • When the studies excluding irritable bowel syndrome cases were analyzed, there were no therapeutic effects of H. pylori eradication on symptomatic improvement. (koreamed.org)
  • 1) Eradication of H. pylori in patients with functional dyspepsia prolongs the gastric half emptying time of a solid meal without eliciting a significant symptomatic improvement. (termedia.pl)
  • If any, the symptomatic benefit of H pylori eradication appeared to be very modest, as has also been shown in a meta-analysis of these data. (bmj.com)
  • H. pylori infec- and Francisca Valcuende become symptomatic ( 3 ). (cdc.gov)
  • The role of H. pylori in nonulcer dyspepsia is less clear. (aafp.org)
  • Eradication of Helicobacter pylori infection effectively cures patients with peptic ulcer disease, but the effect of such treatment on patients with nonulcer dyspepsia is less well established. (aafp.org)
  • The most common cause of ulcers is infection of the stomach by bacteria called Helicobacter pylori ( H pylori ). (medlineplus.gov)
  • More than 90 % of gastroduodenal ulcers are associated with Helicobacter pylori ( H. pylori, formerly known as Campylobacter pylori ) infection, whether on first presentation or on recurrence. (aetna.com)
  • Helicobacter pylori -A spiral-shaped Gram-negative bacterium that lives in the lining of the stomach and is known to cause gastric ulcers. (encyclopedia.com)
  • See related handout on H. pylori and stomach ulcers , written by the authors of this article. (aafp.org)
  • 1 An important cause of dyspepsia is peptic ulcer disease (PUD), which includes gastric and duodenal ulcers. (aafp.org)
  • Helicobacter pylori infection is associated with 95% of duodenal ulcers and more than 80% of gastric ulcers. (nih.gov)
  • Two pa- pylori has been observed in patients thologists reviewed hematoxylin and with ulcers, intestinal metaplasia, and The opinions expressed by authors eosin-stained slides prepared from adenocarcinoma, the bacteria usually contributing to this journal do not formalin-fi xed, paraffi n-embedded are present in areas of the stomach that gastric biopsy specimens. (cdc.gov)
  • Helicobacter pylori: epidemiology and routes of transmission. (cogprints.org)
  • The following case-based review will highlight these issues, including the epidemiology of H. pylori in the immigrant population, an approach to dyspepsia, and the role of H. pylori in gastric adenocarcinoma. (nih.gov)
  • 3 ] The testing volume for H. pylori at a national reference laboratory (ARUP Laboratories, Salt Lake City, Utah) suggests that serology is more widely used than would be expected under the AGA-recommended approach. (biomedcentral.com)
  • ARUP received approximately four times as many orders for H. pylori serology between April 1, 2007, and March 31, 2008, than for either stool or breath tests. (biomedcentral.com)
  • Aetna considers H. pylori serology experimental and investigational because of its inadequate performance. (aetna.com)
  • Our study indicates that colonisation screening based on H pylori serology, a history of sinister symptoms, or a history of NSAID use was worthwhile in dyspeptic patients. (nih.gov)
  • Helicobacter pylori seropositivity in serum samples of the KORA study was analyzed by multiplex serology. (frontiersin.org)
  • Helicobacter pylori infection in the stomach was confirmed by a rapid urease test and urea breath tests. (ovid.com)
  • Helicobacter pylori is a gram-negative microaerophilic bacillus likely to be placed in the deep sections of the mucosal gel over the gastric mucosa or even between the mucous layer and the epithelium of the stomach [9]. (scirp.org)
  • Most people who have a peptic ulcer also have bacteria called Helicobacter pylori in their stomach. (nps.org.au)
  • Dyspepsia is a word that has been used in English since the early eighteenth century not only for a variety of stomach ailments but also for bad moods or temper outbursts that were thought to be caused by indigestion. (encyclopedia.com)
  • For many years dyspepsia was a catchall term for any kind of stomach upset characterized by burning, nauseous, or gassy sensations in the upper abdomen. (encyclopedia.com)
  • and to distinguish between organic dyspepsia-stomach upset that can be shown to have a physical cause (for example, stomach irritation caused by alcohol consumption ), and functional dyspepsia (FD)-dyspepsia that cannot be traced to any specific physical cause. (encyclopedia.com)
  • Rome criteria- A set of guidelines for defining and diagnosing functional dyspepsia and other stomach disorders, first drawn up in the mid-1980s by a group of specialists in digestive disorders meeting in Rome, Italy. (encyclopedia.com)
  • Ulcer-like dyspepsia - pain related to the stomach area. (nursinginpractice.com)
  • Helicobacter pylori is associated with stomach cancer, and Mycobacterium, some other bacteria and parasites also have an effect. (wikipedia.org)
  • Bacterial infection may also increase the risk of cancer, as seen in Helicobacter pylori-induced stomach cancer. (wikipedia.org)
  • Liver cancer is largely caused by infectious hepatitis B virus (HBV) plus hepatitis C virus (HBC) and stomach cancer is largely caused by Helicobacter pylori bacteria. (wikipedia.org)
  • Moreover, what is known about variations in host susceptibility and H. pylori virulence has not been correlated with specific symptoms ( 1 ). (cdc.gov)
  • Aging increases, and duodenal ulcer reduces the risk for intestinal metaplasia of the gastric corpus in Japanese patients with dyspepsia. (qxmd.com)
  • Thirty-nine patients had active duodenal ulcer (DU) and 16 non-ulcer dyspepsia (NUD), and all tested positive for HP. (unifesp.br)
  • In Nigeria, H. pylori prevalence rate of up to 84% has been reported among patients with dyspepsia in general ( 4 ), while almost 100% of duodenal ulcer (DU) patients and 82% of patients with gastric ulcer (GU) were found to be H. pylori positive ( 5 ). (ispub.com)
  • ABSTRACT Helicobacter pylori the causative organism and has a possible role in the development of peptic ulcer disease (PUD) and gastric cancer. (issuu.com)
  • Dyspepsia, also known as indigestion, is a term that describes discomfort or pain in the upper abdomen. (medicalnewstoday.com)
  • Dyspepsia is the same as indigestion, and it is not a disease. (medicalnewstoday.com)
  • If the doctor finds no causes for indigestion after a thorough evaluation, and the person with dyspepsia has not responded to treatments, the doctor may prescribe low-dose antidepressants . (medicalnewstoday.com)
  • For people with functional dyspepsia, psychological therapy can help manage the cognitive aspects of indigestion. (medicalnewstoday.com)
  • Several phrases that are still used almost interchangeably for the condition are gastric indigestion, nervous dyspepsia, and impaired gastric function. (encyclopedia.com)
  • Functional indigestion (previously called nonulcer dyspepsia) is indigestion without evidence of underlying disease. (wikipedia.org)
  • Gastric biopsies were taken from all patients for detection of H.pylori by RUT, culture and PCR. (ibimapublishing.com)
  • The electrochemical properties of H. pylori allow these lesions to be rapidly and accurately detected in gastric biopsies. (qxmd.com)
  • Apium graveolens and Trachyspermum copticom was more effective than omeprazole and placebo in reducing the symptoms in functional dyspepsia patients. (greenmedinfo.com)
  • Dyspepsia was modestly reduced after the screening and treatment procedure, and the result was not sufficiently extensive to have an effect on the use of health care or to improve quality of life. (nih.gov)
  • All randomized controlled trials comparing drugs in any of the six groups with each other or with placebo for treatment of nonulcer dyspepsia. (aafp.org)
  • After test of cure at Visit 5, all H. pylori eradication failures will receive susceptibility directed Standard of Care therapy based on initial culture results for subjects, and undergo repeat upper endoscopy for post treatment antibiotic susceptibility/resistance assessment. (centerwatch.com)
  • Helicobacter pylori testing plus eradication was as effective and safe as prompt endoscopy for the primary care treatment of patients with dyspepsia but had greater patient dissatisfaction. (bmj.com)
  • Secondary outcomes were proportion of asymptomatic patients and treatment success according to H. pylori status. (acpjc.org)
  • Treatment was more successful in patients in whom H. pylori was eradicated than in those it was not (54% vs 39%, P = 0.02). (acpjc.org)
  • The present study investigated the effect of H pylori treatment in patients with functional dyspepsia resistant to conventional treatment. (bmj.com)
  • In functional dyspepsia, H pylori treatment and cure of H pylori are no more effective for symptoms over six months than short term acid inhibition. (bmj.com)
  • These results do not support treatment of H pylori in functional dyspepsia. (bmj.com)
  • In addition, exclusion of patients who responded to acid reducing drugs may facilitate the detection of a potential effect of H pylori treatment. (bmj.com)
  • Thus we have conducted a study in patients with functional dyspepsia who were resistant to standard treatment. (bmj.com)
  • A number of published articles address the cost-effectiveness of H. pylori management, but most of these primarily compare treatment options after a patient has already been diagnosed with H. pylori . (biomedcentral.com)
  • 26 - 32 ] Still others compare the effectiveness within a small subset of tests of diagnosing H. pylori infection or of determining the efficacy of treatment. (biomedcentral.com)
  • Peptic ulceration in the absence of nonsteroidal anti-inflammatory drugs is usually associated with H. pylori infection, and eradication is an effective treatment. (acponline.org)
  • Even after three previous H. pylori eradication failures, an empirical fourth-line rescue treatment with rifabutin may be effective. (qxmd.com)
  • In these trials, the mean placebo response rate at one year was 28 percent, and the mean H. pylori eradication treatment response rate was 36 percent. (aafp.org)
  • Overall, eradication treatment of H. pylori had no significant effect on quality of life compared with placebo. (aafp.org)
  • The decisions about cost-effectiveness of treatment depended primarily on the willingness of the patient to pay for each month free of dyspepsia symptoms and to accept an uncertain outcome. (aafp.org)
  • The authors estimate that H. pylori eradication therapy would cost approximately $112 per dyspepsia-free month during the first year after treatment. (aafp.org)
  • Systematic review and economic evaluation of Helicobacter pylori eradication treatment for non-ulcer dyspepsia. (aafp.org)
  • Empirical acid suppression is one of the main approaches for the treatment of functional dyspepsia [ 7 ]. (omicsonline.org)
  • More recently, the identification of hydrogen potassium stimulated adenosine triphosphatase (H+K+-ATPase) as the proton pump of the parietal cells and Helicobacter pylori (HP) infection as the main cause of peptic ulcer, heralded a new revolution in our understanding and treatment of acid peptic disorder. (omicsonline.org)
  • Adults aged 55 and over with dyspepsia or reflux symptoms that have not responded to treatment have a discussion with their GP about referral for non-urgent direct access endoscopy. (guidelinesinpractice.co.uk)
  • Eradication of helicobacter pylori is important for treatment of GU but ideal regimen is not available. (clinicaltrials.gov)
  • There is clear evidence that treatment of H. pylori resolves peptic ulcer disease, and increasing evidence for protection against development of gastric adenocarcinoma. (nih.gov)
  • However, H. pylori treatment failure is common and alternative regimens may be necessary. (nih.gov)
  • The benefit of treatment to eradicate H. pylori in functional dyspepsia remains controversial ( 3 , 4 ). (cdc.gov)
  • Post treatment assessment in both HP (95.7%, 22/23) and non HP-related dyspepsia (86.7%, 65/75) groups showed complete or almost complete resolution of dyspepsia. (biomedcentral.com)
  • Response to Treatment of Helicobacter pylori-associated Dyspepsia: Eradication of Helicobacter pylori or Correction of Gastric or Intestinal Dysbiosis? (bvsalud.org)
  • The remaining 70 (38%) patients who were H pylori seronegative, had no sinister symptoms, and had not taken NSAIDs (screen-negative), did not undergo endoscopy but were returned to their primary care physician for treatment of symptoms. (nih.gov)
  • Otherwise, testing for H. pylori followed by treatment of the infection if present is reasonable. (wikipedia.org)
  • The trials by McColl and Chiba and their colleagues provide important information for physicians managing patients presenting with uninvestigated dyspepsia. (acpjc.org)
  • However, the combination cagA+-vacA s1m1 was found more frequently among the H. pylori strains from peptic ulcer patients 52% than among strains isolated from NUD patients 26%, this difference was statistically significant p = 0.035. (duhnnae.com)
  • Eradication of H. pylori would slightly decrease this patient's chance of having persistent symptoms over the next three to 12 months. (aafp.org)
  • Adults with persistent, unexplained dyspepsia or reflux symptoms have a discussion with their GP about referral to a specialist service. (guidelinesinpractice.co.uk)
  • of these, 27 (54%) and 15 (30%) had H pylori in antral and fundal biopsies respectively. (who.int)
  • The biopsy samples will also be used to conduct H. pylori antibiotic susceptibility/resistance assessment. (centerwatch.com)
  • Biopsy specimens were obtained from patients with dyspepsia on esophagogastroduodenoscopy (EGD) for rapid urease test, histology and PCR examination for Helicobacter genus specific 16S rDNA, H. pylori phosphoglucosamine mutase ( glmM ) and urease B ( ureB ) gene of H. heilmannii and H. felis . (pubmedcentralcanada.ca)
  • Human gastric biopsy samples, however, have shown to harbor bacteria which were morphologically different from H. pylori [ 5 , 6 ]. (pubmedcentralcanada.ca)
  • Patients whose medical records and postulated to lack characteristics that gastric biopsy slides were available sustain growth of H. pylori . (cdc.gov)
  • In patients with dyspepsia and a positive test result for Helicobacter pylori , is an H. pylori eradication strategy more effective than placebo for improving dyspepsia symptoms? (acpjc.org)
  • Patients with functional dyspepsia show a high rate of placebo effect in trials of new medications for the disorder. (encyclopedia.com)
  • Outstanding H.pylori characteristics that permit gastric colonization include microerophilism for survival within mucus gel, spiral shape and flagella for motility within the viscous layer and urease activity, which generate ammonium ions that buffer gastric acidity [17]. (issuu.com)
  • H. pylori eradication does not contribute to the development of gastroesophageal reflux disease or worsen its course. (qxmd.com)
  • All the H. heilmannii and H. felis PCR positive patients were also positive for H. pylori PCR amplification. (pubmedcentralcanada.ca)
  • Results showed that 66.5%, 69.5%, 71% and 67.5% of patients were positive for H.pylori infection by RUT, RDT, culture and PCR, respectively. (ibimapublishing.com)
  • RESULTS: 40% of the study group tested positive for H pylori. (nihr.ac.uk)
  • A total of 259 (78.5%) of the patients were positive for H. pylori. (ispub.com)
  • The test-and-treat strategy for detecting H. pylori is appropriate in situations where the risk of gastric cancer is low based on age younger than 55 years and the absence of alarm symptoms. (aafp.org)
  • Use the test-and-treat strategy for patients with dyspepsia who are younger than 55 years and have no alarm symptoms for gastric cancer. (aafp.org)
  • The aim of this study was to assess whether screening and eradication of Hp in a general population would reduce the prevalence of dyspepsia and the incidence of peptic ulcer and thus save health care resources and improve quality of life. (nih.gov)
  • In each particular population, there is a close correlation between the prevalence of H. pylori infection and the incidence of gastric cancer. (qxmd.com)
  • The incidence of H.pylori has been progressively declining in the United States and other developed countries [11]. (issuu.com)
  • decades, the incidence of PUD has decreased significantly, which is believed to be due to the decrease in H.pylori infection, particularly in developed countries [14]. (issuu.com)
  • Therefore, we investigated the incidence of H. pylori infection and its relationship with gastric emptying in cirrhotic patients with dyspepsia. (unboundmedicine.com)
  • The incidence of H. pylori infection was 52.5% overall. (unboundmedicine.com)
  • A prospective randomised trial of a "test and treat" policy versus endoscopy based management in young Helicobacter pylori positive patients with ulcer-like dyspepsia, referred to hospital clinic. (cogprints.org)
  • This has led to recommendations such as acid reduction in reflux-like and ulcer-like dyspepsia and the use of motility stimulants (prokinetic drugs) in dysmotility-like dyspepsia. (bmj.com)
  • 1.4.4 Offer H pylori 'test and treat' to people with dyspepsia. (nice.org.uk)
  • In about 50-70% of people with dyspepsia, no definite organic cause can be determined. (wikipedia.org)
  • Helicobacter pylori infection in asymptomatic children: impact of epidemiologic factors on accuracy of diagnostic tests. (cogprints.org)
  • The prevalence of H. pylori in NUD has not been convincingly shown to differ from that in asymptomatic controls. (acponline.org)
  • Screening of asymptomatic persons for H. pylori infection. (aetna.com)
  • The prevalence of Helicobacter pylori infection was studied in 138 patients with dyspepsia in a hospital in Nakuru, Kenya, and in 138 asymptomatic sex- and age-matched controls from the same population. (cdc.gov)
  • H. pylori infection in asymptomatic residents of Nakuru, Kenya, was more prevalent in older persons, with a rate of 68%, than in those 31-40 years of age. (cdc.gov)
  • As the majority of H. pylori infections are asymptomatic, eradication therapy is not applied to these persons and the infection persists over time, leading to inflammatory changes of the gastric mucosa. (frontiersin.org)
  • Helicobacter pylori infection is a high prevalence infection worldwide, and it is more common in developing countries than developed ones (Magalhães and Luzza, 2006). (ibimapublishing.com)
  • However, young persons with dyspepsia had an unexpectedly high prevalence of H. pylori infection. (cdc.gov)
  • CONCLUSIONS: The authors believed that the high prevalence of the tests used to identify H. pylori in patients with NUD can be explained by the selected group of patients, which belong to the low socio-economic class. (unicamp.br)
  • H. pylori is the main cause of peptic ulcer disease. (aafp.org)
  • There is paucity of information on the prevalence of Helicobacter pylori infection in Nigeria. (cogprints.org)