A genus in the family FELIDAE comprising one species, Puma concolor. It is a large, long-tailed, feline of uniform color. The names puma, cougar, and mountain lion are used interchangeably for this species. There are more than 20 subspecies.
A large group of proteins that control APOPTOSIS. This family of proteins includes many ONCOGENE PROTEINS as well as a wide variety of classes of INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS such as CASPASES.
Products of proto-oncogenes. Normally they do not have oncogenic or transforming properties, but are involved in the regulation or differentiation of cell growth. They often have protein kinase activity.
Nuclear phosphoprotein encoded by the p53 gene (GENES, P53) whose normal function is to control CELL PROLIFERATION and APOPTOSIS. A mutant or absent p53 protein has been found in LEUKEMIA; OSTEOSARCOMA; LUNG CANCER; and COLORECTAL CANCER.
One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.
A genus in the family FELIDAE comprising felines with long legs, ear tufts, and a short tail.
A member of the Bcl-2 protein family and homologous partner of C-BCL-2 PROTO-ONCOGENE PROTEIN. It regulates the release of CYTOCHROME C and APOPTOSIS INDUCING FACTOR from the MITOCHONDRIA. Several isoforms of BCL2-associated X protein occur due to ALTERNATIVE SPLICING of the mRNA for this protein.
Proteins that are normally involved in holding cellular growth in check. Deficiencies or abnormalities in these proteins may lead to unregulated cell growth and tumor development.
Membrane proteins encoded by the BCL-2 GENES and serving as potent inhibitors of cell death by APOPTOSIS. The proteins are found on mitochondrial, microsomal, and NUCLEAR MEMBRANE sites within many cell types. Overexpression of bcl-2 proteins, due to a translocation of the gene, is associated with follicular lymphoma.
An order of MAMMALS, usually flesh eaters with appropriate dentition. Suborders include the terrestrial carnivores Fissipedia, and the aquatic carnivores PINNIPEDIA.
The cat family in the order CARNIVORA comprised of muscular, deep-chested terrestrial carnivores with a highly predatory lifestyle.
A multi-domain mitochondrial membrane protein and member of the bcl-2 Protein family. Bak protein interacts with TUMOR SUPPRESSOR PROTEIN P53 and promotes APOPTOSIS.
Large, chiefly nocturnal mammals of the cat family FELIDAE, species Panthera leo. They are found in Africa and southern Asia.
A member of the myeloid leukemia factor (MLF) protein family with multiple alternatively spliced transcript variants encoding different protein isoforms. In hematopoietic cells, it is located mainly in the nucleus, and in non-hematopoietic cells, primarily in the cytoplasm with a punctate nuclear localization. MLF1 plays a role in cell cycle differentiation.
A genus of long-legged, swift-moving felines (FELIDAE) from Africa (and formerly Asia) about the size of a small leopard.
A cell line derived from cultured tumor cells.
A member of the bcl-2 protein family that plays a role in the regulation of APOPTOSIS. Two major isoforms of the protein exist due to ALTERNATIVE SPLICING of the BCL2L1 mRNA and are referred to as Bcl-XS and Bcl-XL.
Compounds with a benzene ring fused to a thiazole ring.
Human COLORECTAL CARCINOMA cell line.
A species of LENTIVIRUS, subgenus feline lentiviruses (LENTIVIRUSES, FELINE) isolated from cats with a chronic wasting syndrome, presumed to be immune deficiency. There are 3 strains: Petaluma (FIP-P), Oma (FIP-O) and Puma lentivirus (PLV). There is no antigenic relationship between FIV and HIV, nor does FIV grow in human T-cells.
Cytochromes of the c type that are found in eukaryotic MITOCHONDRIA. They serve as redox intermediates that accept electrons from MITOCHONDRIAL ELECTRON TRANSPORT COMPLEX III and transfer them to MITOCHONDRIAL ELECTRON TRANSPORT COMPLEX IV.
A member of the Bcl-2 protein family that reversibly binds MEMBRANES. It is a pro-apoptotic protein that is activated by caspase cleavage.
A widely used industrial solvent.
A superfamily of polymyarian nematode worms. An important characteristic of this group is the presence of three prominent lips around the mouth of the organism.
'Zoo animals' are various species of captive wild animals, housed and displayed in a facility for the purpose of public education, conservation, research, and recreation.
Injuries to DNA that introduce deviations from its normal, intact structure and which may, if left unrepaired, result in a MUTATION or a block of DNA REPLICATION. These deviations may be caused by physical or chemical agents and occur by natural or unnatural, introduced circumstances. They include the introduction of illegitimate bases during replication or by deamination or other modification of bases; the loss of a base from the DNA backbone leaving an abasic site; single-strand breaks; double strand breaks; and intrastrand (PYRIMIDINE DIMERS) or interstrand crosslinking. Damage can often be repaired (DNA REPAIR). If the damage is extensive, it can induce APOPTOSIS.
Semiautonomous, self-reproducing organelles that occur in the cytoplasm of all cells of most, but not all, eukaryotes. Each mitochondrion is surrounded by a double limiting membrane. The inner membrane is highly invaginated, and its projections are called cristae. Mitochondria are the sites of the reactions of oxidative phosphorylation, which result in the formation of ATP. They contain distinctive RIBOSOMES, transfer RNAs (RNA, TRANSFER); AMINO ACYL T RNA SYNTHETASES; and elongation and termination factors. Mitochondria depend upon genes within the nucleus of the cells in which they reside for many essential messenger RNAs (RNA, MESSENGER). Mitochondria are believed to have arisen from aerobic bacteria that established a symbiotic relationship with primitive protoeukaryotes. (King & Stansfield, A Dictionary of Genetics, 4th ed)
Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.
Nitrophenols are organic compounds characterized by the presence of a nitro group (-NO2) attached to a phenol molecule, known for their potential use in chemical and pharmaceutical industries, but also recognized as environmental pollutants due to their toxicity and potential carcinogenicity.
Proteins which are found in membranes including cellular and intracellular membranes. They consist of two types, peripheral and integral proteins. They include most membrane-associated enzymes, antigenic proteins, transport proteins, and drug, hormone, and lectin receptors.
Animals considered to be wild or feral or not adapted for domestic use. It does not include wild animals in zoos for which ANIMALS, ZOO is available.
Penetrating, high-energy electromagnetic radiation emitted from atomic nuclei during NUCLEAR DECAY. The range of wavelengths of emitted radiation is between 0.1 - 100 pm which overlaps the shorter, more energetic hard X-RAYS wavelengths. The distinction between gamma rays and X-rays is based on their radiation source.
Virus diseases caused by the Lentivirus genus. They are multi-organ diseases characterized by long incubation periods and persistent infection.
Small double-stranded, non-protein coding RNAs (21-31 nucleotides) involved in GENE SILENCING functions, especially RNA INTERFERENCE (RNAi). Endogenously, siRNAs are generated from dsRNAs (RNA, DOUBLE-STRANDED) by the same ribonuclease, Dicer, that generates miRNAs (MICRORNAS). The perfect match of the siRNAs' antisense strand to their target RNAs mediates RNAi by siRNA-guided RNA cleavage. siRNAs fall into different classes including trans-acting siRNA (tasiRNA), repeat-associated RNA (rasiRNA), small-scan RNA (scnRNA), and Piwi protein-interacting RNA (piRNA) and have different specific gene silencing functions.
The span of viability of a cell characterized by the capacity to perform certain functions such as metabolism, growth, reproduction, some form of responsiveness, and adaptability.
A positive regulatory effect on physiological processes at the molecular, cellular, or systemic level. At the molecular level, the major regulatory sites include membrane receptors, genes (GENE EXPRESSION REGULATION), mRNAs (RNA, MESSENGER), and proteins.
I'm sorry for any confusion, but the term "Chile" is not a medical concept or condition, it is a country located in South America. If you have any questions related to medical topics, I would be happy to help answer those!
A short pro-domain caspase that plays an effector role in APOPTOSIS. It is activated by INITIATOR CASPASES such as CASPASE 9. Isoforms of this protein exist due to multiple alternative splicing of its MESSENGER RNA.
Acquired defect of cellular immunity that occurs in cats infected with feline immunodeficiency virus (FIV) and in some cats infected with feline leukemia virus (FeLV).
A CCAAT-enhancer binding protein that is induced by DNA DAMAGE and growth arrest. It serves as a dominant negative inhibitor of other CCAAT-enhancer binding proteins.
An N-acetylglycosamine containing antiviral antibiotic obtained from Streptomyces lysosuperificus. It is also active against some bacteria and fungi, because it inhibits the glucosylation of proteins. Tunicamycin is used as tool in the study of microbial biosynthetic mechanisms.

Puma lentivirus is controlled in domestic cats after mucosal exposure in the absence of conventional indicators of immunity. (1/39)

A high percentage of free-ranging pumas (Felis concolor) are infected with feline lentiviruses (puma lentivirus, feline immunodeficiency virus Pco [FIV-Pco], referred to here as PLV) without evidence of disease. PLV establishes productive infection in domestic cats following parenteral exposure but, in contrast to domestic cat FIV, it does not cause T-cell dysregulation. Here we report that cats exposed to PLV oro-nasally became infected yet rapidly cleared peripheral blood mononuclear cell (PBMC) proviral load in the absence of a correlative specific immune response. Two groups of four specific-pathogen-free cats were exposed to PLV via the mucosal (oro-nasal) or parenteral (i.v.) route. All animals were PBMC culture positive and PCR positive within 3 weeks postinfection and seroconverted without exhibiting clinical disease; however, three or four oro-nasally infected animals cleared circulating proviral DNA within 3 months. Antibody titers reached higher levels in animals that remained persistently infected. PLV antigen-induced proliferation was slightly greater in mucosally inoculated animals, but no differences were noted in cytotoxic T-lymphocyte responses or cytokine profiles between groups. The distribution of virus was predominantly gastrointestinal as opposed to lymphoid in all animals in which virus was detected at necropsy. Possible mechanisms for viral clearance include differences in viral fitness required for crossing mucosal surfaces, a threshold dose requirement for persistence, or an undetected sterilizing host immune response. This is the first report of control of a productive feline or primate lentivirus infection in postnatally exposed, seropositive animals. Mechanisms underlying this observation will provide clues to containment of immunodeficiency disease and could prompt reexamination of vaccine-induced immunity against human immunodeficiency virus and other lentiviruses.  (+info)

Feline lentiviruses demonstrate differences in receptor repertoire and envelope structural elements. (2/39)

Feline immunodeficiency virus (FIV) causes fatal disease in domestic cats via T cell depletion-mediated immunodeficiency. Pumas and lions are hosts for apparently apathogenic lentiviruses (PLV, LLV) distinct from FIV. We compared receptor use among these viruses by: (1) evaluating target cell susceptibility; (2) measuring viral replication following exposure to specific and non-specific receptor antagonists; and (3) comparing Env sequence and structural motifs. Most isolates of LLV and PLV productively infected domestic feline T cells, but differed from domestic cat FIV by infecting cells independent of CXCR4, demonstrating equivalent or enhanced replication following heparin exposure, and demonstrating substantial divergence in amino acid sequence and secondary structure in Env receptor binding domains. PLV infection was, however, inhibited by CD134/OX40 antibody. Thus, although PLV and LLV infection interfere with FIV superinfection, we conclude that LLV and PLV utilize novel, more promiscuous mechanisms for cell entry than FIV, underlying divergent tropism and biological properties of these viruses.  (+info)

The late Miocene radiation of modern Felidae: a genetic assessment. (3/39)

Modern felid species descend from relatively recent (<11 million years ago) divergence and speciation events that produced successful predatory carnivores worldwide but that have confounded taxonomic classifications. A highly resolved molecular phylogeny with divergence dates for all living cat species, derived from autosomal, X-linked, Y-linked, and mitochondrial gene segments (22,789 base pairs) and 16 fossil calibrations define eight principal lineages produced through at least 10 intercontinental migrations facilitated by sea-level fluctuations. A ghost lineage analysis indicates that available felid fossils underestimate (i.e., unrepresented basal branch length) first occurrence by an average of 76%, revealing a low representation of felid lineages in paleontological remains. The phylogenetic performance of distinct gene classes showed that Y-chromosome segments are appreciably more informative than mitochondrial DNA, X-linked, or autosomal genes in resolving the rapid Felidae species radiation.  (+info)

A virus reveals population structure and recent demographic history of its carnivore host. (4/39)

Directly transmitted parasites often provide substantial information about the temporal and spatial characteristics of host-to-host contact. Here, we demonstrate that a fast-evolving virus (feline immunodeficiency virus, FIV) can reveal details of the contemporary population structure and recent demographic history of its natural wildlife host (Puma concolor) that were not apparent from host genetic data and would be impossible to obtain by other means. We suggest that rapidly evolving pathogens may provide a complementary tool for studying population dynamics of their hosts in "shallow" time.  (+info)

Feline lentivirus evolution in cross-species infection reveals extensive G-to-A mutation and selection on key residues in the viral polymerase. (5/39)

Factors that restrict a virus from establishing productive infection in a new host species are important to understand because cross-species transmission events are often associated with emergent viral diseases. To determine the evolutionary pressures on viruses in new host species, we evaluated the molecular evolution of a feline immunodeficiency virus derived from a wild cougar, Puma concolor, during infection of domestic cats. Analyses were based on the coding portion of genome sequences recovered at intervals over 37 weeks of infection of six cats inoculated by either intravenous or oral-nasal routes. All cats inoculated intravenously, but only one inoculated orally-nasally, became persistently viremic. There were notable accumulations of lethal errors and predominance of G-to-A alterations throughout the genome, which were marked in the viral polymerase gene, pol. Viral structural (env and gag) and accessory (vif and orfA) genes evolved neutrally or were under purifying selection. However, sites under positive selection were identified in reverse transcriptase that involved residues in the nucleotide binding pocket or those contacting the RNA-DNA duplex. The findings of extensive G-to-A alterations in this cross-species infection are consistent with the recently described editing of host cytidine deaminase on lentivirus genomes. Additionally, we demonstrate that the primary site of hypermutation is the viral pol gene and the dominant selective force acting on this feline immunodeficiency virus as it replicates in a new host species is on key residues of the virus polymerase.  (+info)

Quantification of Feline immunodeficiency virus (FIVpco) in peripheral blood mononuclear cells, lymph nodes and plasma of naturally infected cougars. (6/39)

Infection of domestic cats with Feline immunodeficiency virus (FIV) results in a fatal immunodeficiency disease, similar to Human immunodeficiency virus 1 (HIV-1) in humans. Elevated plasma viral loads in domestic cats are correlated to decreased survival time and disease progression. However, FIV is also maintained as an apathogenic infection in other members of the family Felidae including cougars, Puma concolour (FIVpco). It is not known whether the lack of disease in cougars is a result of diminished virus replication. A real-time PCR assay was developed to quantify both FIVpco proviral and plasma viral loads in naturally infected cougars. Proviral loads quantified from peripheral blood mononuclear cells (PBMC) ranged from 2.90 x 10(1) to 6.72 x 10(4) copies per 10(6) cells. Plasma viral loads ranged from 2.30 x 10(3) to 2.81 x 10(6) RNA copies ml(-1). These data indicate that FIVpco viral loads are comparable to viral loads observed in endemic and epidemic lentivirus infections. Thus, the lack of disease in cougars is not due to low levels of virus replication. Moreover, significant differences observed among cougar PBMC proviral loads correlated to viral lineage and cougar age (P=0.014), which suggests that separate life strategies exist within FIVpco lineages. This is the first study to demonstrate that an interaction of lentivirus lineage and host age significantly effect proviral loads.  (+info)

Listeric meningoencephalomyelitis in a cougar (Felis concolor): characterization by histopathologic, immunohistochemical, and molecular methods. (7/39)

Listeria monocytogenes has been recognized as an important food-borne pathogen in animals. Records of the disease caused by this bacterium in large felids are, however, rare. The nervous form of listeriosis was diagnosed in a 12-year-old male cougar (Felis concolor) with a several-day history of neurologic disease characterized by excess salivation, head pressing, and circling that progressed to recumbency and death. Microscopically, the main alteration in the brain and spinal cord was a variably severe meningoencephalomyelitis composed mainly of mononuclear cell aggregates with fewer neutrophils. L. monocytogenes was isolated from the brain by microbiological culture, and L. monocytogenes antigen was detected in formalin-fixed, paraffin-embedded sections of brain and spinal cord by immunohistochemical analysis. On the basis of the nucleotide sequence of the 16S rRNA gene, the isolated strain was determined to be serotype 1/2a. Food-borne transmission of the bacterium was suspected, but food was not available for testing.  (+info)

Stochastic predation events and population persistence in bighorn sheep. (8/39)

Many studies have reported temporal changes in the relative importance of density-dependence and environmental stochasticity in affecting population growth rates, but they typically assume that the predominant factor limiting growth remains constant over long periods of time. Stochastic switches in limiting factors that persist for multiple time-steps have received little attention, but most wild populations may periodically experience such switches. Here, we consider the dynamics of three populations of individually marked bighorn sheep (Ovis canadensis) monitored for 24-28 years. Each population experienced one or two distinct cougar (Puma concolor) predation events leading to population declines. The onset and duration of predation events were stochastic and consistent with predation by specialist individuals. A realistic Markov chain model confirms that predation by specialist cougars can cause extinction of isolated populations. We suggest that such processes may be common. In such cases, predator-prey equilibria may only occur at large geographical and temporal scales, and are unlikely with increasing habitat fragmentation.  (+info)

I'm sorry for any confusion, but "Puma" is not a term that has a medical definition. It is a common name for several species of large American cats, and it can also be a brand of sports apparel and footwear. If you have any other health or medical terms you would like me to define, please let me know!

Apoptosis regulatory proteins are a group of proteins that play an essential role in the regulation and execution of apoptosis, also known as programmed cell death. This process is a normal part of development and tissue homeostasis, allowing for the elimination of damaged or unnecessary cells. The balance between pro-apoptotic and anti-apoptotic proteins determines whether a cell will undergo apoptosis.

Pro-apoptotic proteins, such as BAX, BID, and PUMA, promote apoptosis by neutralizing or counteracting the effects of anti-apoptotic proteins or by directly activating the apoptotic pathway. These proteins can be activated in response to various stimuli, including DNA damage, oxidative stress, and activation of the death receptor pathway.

Anti-apoptotic proteins, such as BCL-2, BCL-XL, and MCL-1, inhibit apoptosis by binding and neutralizing pro-apoptotic proteins or by preventing the release of cytochrome c from the mitochondria, which is a key step in the intrinsic apoptotic pathway.

Dysregulation of apoptosis regulatory proteins has been implicated in various diseases, including cancer, neurodegenerative disorders, and autoimmune diseases. Therefore, understanding the role of these proteins in apoptosis regulation is crucial for developing new therapeutic strategies to treat these conditions.

Proto-oncogene proteins are normal cellular proteins that play crucial roles in various cellular processes, such as signal transduction, cell cycle regulation, and apoptosis (programmed cell death). They are involved in the regulation of cell growth, differentiation, and survival under physiological conditions.

When proto-oncogene proteins undergo mutations or aberrations in their expression levels, they can transform into oncogenic forms, leading to uncontrolled cell growth and division. These altered proteins are then referred to as oncogene products or oncoproteins. Oncogenic mutations can occur due to various factors, including genetic predisposition, environmental exposures, and aging.

Examples of proto-oncogene proteins include:

1. Ras proteins: Involved in signal transduction pathways that regulate cell growth and differentiation. Activating mutations in Ras genes are found in various human cancers.
2. Myc proteins: Regulate gene expression related to cell cycle progression, apoptosis, and metabolism. Overexpression of Myc proteins is associated with several types of cancer.
3. EGFR (Epidermal Growth Factor Receptor): A transmembrane receptor tyrosine kinase that regulates cell proliferation, survival, and differentiation. Mutations or overexpression of EGFR are linked to various malignancies, such as lung cancer and glioblastoma.
4. Src family kinases: Intracellular tyrosine kinases that regulate signal transduction pathways involved in cell proliferation, survival, and migration. Dysregulation of Src family kinases is implicated in several types of cancer.
5. Abl kinases: Cytoplasmic tyrosine kinases that regulate various cellular processes, including cell growth, differentiation, and stress responses. Aberrant activation of Abl kinases, as seen in chronic myelogenous leukemia (CML), leads to uncontrolled cell proliferation.

Understanding the roles of proto-oncogene proteins and their dysregulation in cancer development is essential for developing targeted cancer therapies that aim to inhibit or modulate these aberrant signaling pathways.

Tumor suppressor protein p53, also known as p53 or tumor protein p53, is a nuclear phosphoprotein that plays a crucial role in preventing cancer development and maintaining genomic stability. It does so by regulating the cell cycle and acting as a transcription factor for various genes involved in apoptosis (programmed cell death), DNA repair, and cell senescence (permanent cell growth arrest).

In response to cellular stress, such as DNA damage or oncogene activation, p53 becomes activated and accumulates in the nucleus. Activated p53 can then bind to specific DNA sequences and promote the transcription of target genes that help prevent the proliferation of potentially cancerous cells. These targets include genes involved in cell cycle arrest (e.g., CDKN1A/p21), apoptosis (e.g., BAX, PUMA), and DNA repair (e.g., GADD45).

Mutations in the TP53 gene, which encodes p53, are among the most common genetic alterations found in human cancers. These mutations often lead to a loss or reduction of p53's tumor suppressive functions, allowing cancer cells to proliferate uncontrollably and evade apoptosis. As a result, p53 has been referred to as "the guardian of the genome" due to its essential role in preventing tumorigenesis.

Apoptosis is a programmed and controlled cell death process that occurs in multicellular organisms. It is a natural process that helps maintain tissue homeostasis by eliminating damaged, infected, or unwanted cells. During apoptosis, the cell undergoes a series of morphological changes, including cell shrinkage, chromatin condensation, and fragmentation into membrane-bound vesicles called apoptotic bodies. These bodies are then recognized and engulfed by neighboring cells or phagocytic cells, preventing an inflammatory response. Apoptosis is regulated by a complex network of intracellular signaling pathways that involve proteins such as caspases, Bcl-2 family members, and inhibitors of apoptosis (IAPs).

I'm sorry for any confusion, but "Lynx" is not a medical term. It refers to a genus of wild cats that includes the bobcat and several other species. If you have any medical questions or terms you would like defined, please let me know!

BCL-2-associated X protein, often abbreviated as BAX, is a type of protein belonging to the BCL-2 family. The BCL-2 family of proteins plays a crucial role in regulating programmed cell death, also known as apoptosis. Specifically, BAX is a pro-apoptotic protein, which means that it promotes cell death.

BAX is encoded by the BAX gene, and it functions by forming pores in the outer membrane of the mitochondria, leading to the release of cytochrome c and other pro-apoptotic factors into the cytosol. This triggers a cascade of events that ultimately leads to cell death.

Dysregulation of BAX and other BCL-2 family proteins has been implicated in various diseases, including cancer and neurodegenerative disorders. For example, reduced levels of BAX have been observed in some types of cancer, which may contribute to tumor growth and resistance to chemotherapy. On the other hand, excessive activation of BAX has been linked to neuronal death in conditions such as Alzheimer's disease and Parkinson's disease.

Tumor suppressor proteins are a type of regulatory protein that helps control the cell cycle and prevent cells from dividing and growing in an uncontrolled manner. They work to inhibit tumor growth by preventing the formation of tumors or slowing down their progression. These proteins can repair damaged DNA, regulate gene expression, and initiate programmed cell death (apoptosis) if the damage is too severe for repair.

Mutations in tumor suppressor genes, which provide the code for these proteins, can lead to a decrease or loss of function in the resulting protein. This can result in uncontrolled cell growth and division, leading to the formation of tumors and cancer. Examples of tumor suppressor proteins include p53, Rb (retinoblastoma), and BRCA1/2.

Proto-oncogene proteins c-bcl-2 are a group of proteins that play a role in regulating cell death (apoptosis). The c-bcl-2 gene produces one of these proteins, which helps to prevent cells from undergoing apoptosis. This protein is located on the membrane of mitochondria and endoplasmic reticulum and it can inhibit the release of cytochrome c, a key player in the activation of caspases, which are enzymes that trigger apoptosis.

In normal cells, the regulation of c-bcl-2 protein helps to maintain a balance between cell proliferation and cell death, ensuring proper tissue homeostasis. However, when the c-bcl-2 gene is mutated or its expression is dysregulated, it can contribute to cancer development by allowing cancer cells to survive and proliferate. High levels of c-bcl-2 protein have been found in many types of cancer, including leukemia, lymphoma, and carcinomas, and are often associated with a poor prognosis.

Carnivora is an order of mammals that consists of animals whose primary diet consists of flesh. The term "Carnivora" comes from the Latin words "caro", meaning flesh, and "vorare", meaning to devour. This order includes a wide variety of species, ranging from large predators such as lions, tigers, and bears, to smaller animals such as weasels, otters, and raccoons.

While members of the Carnivora order are often referred to as "carnivores," it is important to note that not all members exclusively eat meat. Some species, such as raccoons and bears, have an omnivorous diet that includes both plants and animals. Additionally, some species within this order have evolved specialized adaptations for their specific diets, such as the elongated canines and carnassial teeth of felids (cats) and canids (dogs), which are adapted for tearing and shearing meat.

Overall, the medical definition of Carnivora refers to an order of mammals that have a diet primarily consisting of flesh, although not all members exclusively eat meat.

Felidae is the biological family that includes all extant (living) members of the cat group, also known as felids. This family consists of big cats such as lions, tigers, and leopards, as well as small cats like domestic cats, cheetahs, and pumas. Felidae is part of the order Carnivora and is characterized by specialized adaptations for hunting and stalking prey, including retractile claws, sharp teeth, and flexible bodies. The family has a worldwide distribution, with species found in various habitats across all continents except Antarctica.

BAK (Bcl-2 Homologous Antagonist-Killer) protein is a member of the Bcl-2 family, which consists of proteins that regulate programmed cell death, also known as apoptosis. The Bcl-2 family includes both pro-apoptotic and anti-apoptotic members, and their interactions play a crucial role in determining whether a cell lives or dies.

BAK is a pro-apoptotic protein that forms oligomers and creates pores in the outer mitochondrial membrane, leading to the release of cytochrome c and other pro-apoptotic factors into the cytosol. This triggers a cascade of events that ultimately results in cell death.

BAK is kept in an inactive state under normal conditions by binding to anti-apoptotic Bcl-2 family members, such as Bcl-xL and Mcl-1. However, when cells receive signals to undergo apoptosis, the interactions between pro- and anti-apoptotic proteins are disrupted, allowing BAK to become activated and initiate the cell death process.

In summary, BAK is a crucial protein involved in regulating programmed cell death, and its dysregulation has been implicated in various diseases, including cancer and neurodegenerative disorders.

I'm sorry for any confusion, but "Lions" is not a term typically used in medical definitions. Lions are large, carnivorous mammals that are part of the Felidae family, specifically Panthera leo. If you have any questions about lions or if there's another term you meant to ask about, please provide more context so I can give you a more accurate response.

Medical Definition:
Myeloid Cell Leukemia Sequence 1 Protein (MCSFR1) is a transmembrane receptor protein that belongs to the class III receptor tyrosine kinase family. It is also known as CD115 or CSF1R. This protein plays a crucial role in the survival, differentiation, and proliferation of mononuclear phagocytes, including macrophages and osteoclasts. The MCSFR1 protein binds to its ligands, colony-stimulating factor 1 (CSF1) and interleukin-34 (IL-34), leading to the activation of various intracellular signaling pathways that regulate cellular functions.

In the context of cancer, particularly in myeloid leukemias, chromosomal rearrangements can lead to the formation of the MCSFR1 fusion proteins, which have been implicated in the pathogenesis of certain types of leukemia, such as acute myeloid leukemia (AML) and chronic myelomonocytic leukemia (CMML). These fusion proteins can lead to constitutive activation of signaling pathways, promoting cell growth and survival, ultimately contributing to leukemic transformation.

"Acinonyx" is a genus name that refers to a single species of big cat, the cheetah. The correct medical definition of "Acinonyx" is:

* Acinonyx jubatus: a large, slender wild cat that is known for its incredible speed and unique adaptations for running. It is the fastest land animal, capable of reaching speeds up to 60-70 miles per hour. The cheetah's body is built for speed, with long legs, a flexible spine, and a non-retractable claw that provides traction while running.

The cheetah's habitat ranges from the savannas of Africa to the deserts of Iran. It primarily hunts medium-sized ungulates, such as gazelles and wildebeest. The cheetah's population has been declining due to habitat loss, human-wildlife conflict, and illegal wildlife trade. Conservation efforts are underway to protect this iconic species and its habitat.

A cell line that is derived from tumor cells and has been adapted to grow in culture. These cell lines are often used in research to study the characteristics of cancer cells, including their growth patterns, genetic changes, and responses to various treatments. They can be established from many different types of tumors, such as carcinomas, sarcomas, and leukemias. Once established, these cell lines can be grown and maintained indefinitely in the laboratory, allowing researchers to conduct experiments and studies that would not be feasible using primary tumor cells. It is important to note that tumor cell lines may not always accurately represent the behavior of the original tumor, as they can undergo genetic changes during their time in culture.

Bcl-x is a protein that belongs to the Bcl-2 family, which regulates programmed cell death (apoptosis). Specifically, Bcl-x has both pro-survival and pro-apoptotic functions, depending on its splice variants. The long form of Bcl-x (Bcl-xL) is a potent inhibitor of apoptosis, while the short form (Bcl-xS) promotes cell death. Bcl-x plays critical roles in various cellular processes, including development, homeostasis, and stress responses, by controlling the mitochondrial outer membrane permeabilization and the release of cytochrome c, which eventually leads to caspase activation and apoptosis. Dysregulation of Bcl-x has been implicated in several diseases, such as cancer and neurodegenerative disorders.

Benzothiazoles are a class of heterocyclic organic compounds that contain a benzene fused to a thiazole ring. They have the chemical formula C7H5NS. Benzothiazoles and their derivatives have a wide range of applications in various industries, including pharmaceuticals, agrochemicals, dyes, and materials science.

In the medical field, benzothiazoles have been studied for their potential therapeutic properties. Some benzothiazole derivatives have shown promising results as anti-inflammatory, antimicrobial, antiviral, and anticancer agents. However, more research is needed to fully understand the medical potential of these compounds and to develop safe and effective drugs based on them.

It's important to note that while benzothiazoles themselves have some biological activity, most of the medical applications come from their derivatives, which are modified versions of the basic benzothiazole structure. These modifications can significantly alter the properties of the compound, leading to new therapeutic possibilities.

HCT116 cells are a type of human colon cancer cell line that is widely used in scientific research. They were originally established in the early 1980s from a primary colon tumor that had metastasized to the liver. HCT116 cells are known for their stability, robust growth, and susceptibility to various genetic manipulations, making them a popular choice for studying cancer biology, drug discovery, and gene function.

These cells have several important features that make them useful in research. For example, they harbor mutations in key genes involved in colorectal cancer development, such as the adenomatous polyposis coli (APC) gene and the KRAS oncogene. Additionally, HCT116 cells can be easily cultured in the lab and are amenable to a variety of experimental techniques, including genetic modification, drug screening, and protein analysis.

It is important to note that while HCT116 cells provide valuable insights into colon cancer biology, they represent only one type of cancer cell line, and their behavior may not necessarily reflect the complexity of human tumors in vivo. Therefore, researchers must exercise caution when interpreting results obtained from these cells and consider other complementary approaches to validate their findings.

Feline Immunodeficiency Virus (FIV) is a lentivirus that primarily affects felines, including domestic cats and wild cats. It is the feline equivalent of Human Immunodeficiency Virus (HIV). The virus attacks the immune system, specifically the CD4+ T-cells, leading to a decline in the immune function over time.

This makes the infected cat more susceptible to various secondary infections and diseases. It is usually transmitted through bite wounds from infected cats during fighting or mating. Mother to offspring transmission can also occur, either in utero, during birth, or through nursing.

There is no cure for FIV, but antiretroviral therapy can help manage the disease and improve the quality of life for infected cats. It's important to note that while FIV-positive cats can live normal lives for many years, they should be kept indoors to prevent transmission to other cats and to protect them from opportunistic infections.

Cytochromes c are a group of small heme proteins found in the mitochondria of cells, involved in the electron transport chain and play a crucial role in cellular respiration. They accept and donate electrons during the process of oxidative phosphorylation, which generates ATP, the main energy currency of the cell. Cytochromes c contain a heme group, an organic compound that includes iron, which facilitates the transfer of electrons. The "c" in cytochromes c refers to the type of heme group they contain (cyt c has heme c). They are highly conserved across species and have been widely used as a molecular marker for evolutionary studies.

BH3 Interacting Domain Death Agonist Protein, also known as BAD protein, is a member of the Bcl-2 family of proteins. This protein is involved in the regulation of programmed cell death, or apoptosis. The BH3 domain of BAD protein allows it to interact with other members of the Bcl-2 family and modulate their function. When activated, BAD protein can promote cell death by binding to and inhibiting anti-apoptotic proteins such as Bcl-2 and Bcl-xL. This helps to release pro-apoptotic proteins such as Bax and Bak, which can then trigger the intrinsic pathway of apoptosis. The activation of BAD protein is tightly regulated by post-translational modifications, including phosphorylation and dephosphorylation, which can be influenced by various signals within the cell.

Toluene is not a medical condition or disease, but it is a chemical compound that is widely used in various industrial and commercial applications. Medically, toluene can be relevant as a substance of abuse due to its intoxicating effects when inhaled or sniffed. It is a colorless liquid with a distinctive sweet aroma, and it is a common solvent found in many products such as paint thinners, adhesives, and rubber cement.

In the context of medical toxicology, toluene exposure can lead to various health issues, including neurological damage, cognitive impairment, memory loss, nausea, vomiting, and hearing and vision problems. Chronic exposure to toluene can also cause significant harm to the developing fetus during pregnancy, leading to developmental delays, behavioral problems, and physical abnormalities.

Ascaridoidea is a superfamily of parasitic nematode roundworms that includes several medically important genera such as Ascaris, Toxocara, and Baylisascaris. These worms have a complex life cycle involving intermediate hosts like insects or mammals, and definitive hosts such as humans or other animals.

In humans, the most common species of Ascaridoidea are Ascaris lumbricoides (also known as "human roundworm") and Toxocara canis (dog roundworm) or Toxocara cati (cat roundworm). Infection with these parasites typically occurs through ingestion of contaminated food, water, or soil.

Ascaris lumbricoides infection, known as ascariasis, can cause symptoms such as abdominal pain, nausea, vomiting, and diarrhea. Severe infections may lead to intestinal obstruction, malnutrition, or impaired growth in children.

Toxocara infection, also called toxocariasis, can result in visceral larva migrans (VLM) or ocular larva migrans (OLM), depending on the organs affected. VLM may cause fever, cough, wheezing, and hepatomegaly, while OLM can lead to vision loss or eye inflammation.

Preventive measures include proper hygiene practices, such as handwashing, cooking food thoroughly, and avoiding contact with contaminated soil or feces. In some cases, medication may be necessary to treat these infections.

"Animals, Zoo" is not a medical term. However, it generally refers to a collection of various species of wild animals kept in enclosures or exhibits for the public to view and learn about. These animals are usually obtained from different parts of the world and live in environments that attempt to simulate their natural habitats. Zoos play an essential role in conservation efforts, education, and research. They provide a unique opportunity for people to connect with wildlife and understand the importance of preserving and protecting endangered species and their ecosystems.

DNA damage refers to any alteration in the structure or composition of deoxyribonucleic acid (DNA), which is the genetic material present in cells. DNA damage can result from various internal and external factors, including environmental exposures such as ultraviolet radiation, tobacco smoke, and certain chemicals, as well as normal cellular processes such as replication and oxidative metabolism.

Examples of DNA damage include base modifications, base deletions or insertions, single-strand breaks, double-strand breaks, and crosslinks between the two strands of the DNA helix. These types of damage can lead to mutations, genomic instability, and chromosomal aberrations, which can contribute to the development of diseases such as cancer, neurodegenerative disorders, and aging-related conditions.

The body has several mechanisms for repairing DNA damage, including base excision repair, nucleotide excision repair, mismatch repair, and double-strand break repair. However, if the damage is too extensive or the repair mechanisms are impaired, the cell may undergo apoptosis (programmed cell death) to prevent the propagation of potentially harmful mutations.

Mitochondria are specialized structures located inside cells that convert the energy from food into ATP (adenosine triphosphate), which is the primary form of energy used by cells. They are often referred to as the "powerhouses" of the cell because they generate most of the cell's supply of chemical energy. Mitochondria are also involved in various other cellular processes, such as signaling, differentiation, and apoptosis (programmed cell death).

Mitochondria have their own DNA, known as mitochondrial DNA (mtDNA), which is inherited maternally. This means that mtDNA is passed down from the mother to her offspring through the egg cells. Mitochondrial dysfunction has been linked to a variety of diseases and conditions, including neurodegenerative disorders, diabetes, and aging.

A "knockout" mouse is a genetically engineered mouse in which one or more genes have been deleted or "knocked out" using molecular biology techniques. This allows researchers to study the function of specific genes and their role in various biological processes, as well as potential associations with human diseases. The mice are generated by introducing targeted DNA modifications into embryonic stem cells, which are then used to create a live animal. Knockout mice have been widely used in biomedical research to investigate gene function, disease mechanisms, and potential therapeutic targets.

Nitrophenols are organic compounds that contain a hydroxyl group (-OH) attached to a phenyl ring (aromatic hydrocarbon) and one or more nitro groups (-NO2). They have the general structure R-C6H4-NO2, where R represents the hydroxyl group.

Nitrophenols are known for their distinctive yellow to brown color and can be found in various natural sources such as plants and microorganisms. Some common nitrophenols include:

* p-Nitrophenol (4-nitrophenol)
* o-Nitrophenol (2-nitrophenol)
* m-Nitrophenol (3-nitrophenol)

These compounds are used in various industrial applications, including dyes, pharmaceuticals, and agrochemicals. However, they can also be harmful to human health and the environment, as some nitrophenols have been identified as potential environmental pollutants and may pose risks to human health upon exposure.

Membrane proteins are a type of protein that are embedded in the lipid bilayer of biological membranes, such as the plasma membrane of cells or the inner membrane of mitochondria. These proteins play crucial roles in various cellular processes, including:

1. Cell-cell recognition and signaling
2. Transport of molecules across the membrane (selective permeability)
3. Enzymatic reactions at the membrane surface
4. Energy transduction and conversion
5. Mechanosensation and signal transduction

Membrane proteins can be classified into two main categories: integral membrane proteins, which are permanently associated with the lipid bilayer, and peripheral membrane proteins, which are temporarily or loosely attached to the membrane surface. Integral membrane proteins can further be divided into three subcategories based on their topology:

1. Transmembrane proteins, which span the entire width of the lipid bilayer with one or more alpha-helices or beta-barrels.
2. Lipid-anchored proteins, which are covalently attached to lipids in the membrane via a glycosylphosphatidylinositol (GPI) anchor or other lipid modifications.
3. Monotopic proteins, which are partially embedded in the membrane and have one or more domains exposed to either side of the bilayer.

Membrane proteins are essential for maintaining cellular homeostasis and are targets for various therapeutic interventions, including drug development and gene therapy. However, their structural complexity and hydrophobicity make them challenging to study using traditional biochemical methods, requiring specialized techniques such as X-ray crystallography, nuclear magnetic resonance (NMR) spectroscopy, and single-particle cryo-electron microscopy (cryo-EM).

Wild animals are those species of animals that are not domesticated or tamed by humans and live in their natural habitats without regular human intervention. They can include a wide variety of species, ranging from mammals, birds, reptiles, amphibians, fish, to insects and other invertebrates.

Wild animals are adapted to survive in specific environments and have behaviors, physical traits, and social structures that enable them to find food, shelter, and mates. They can be found in various habitats such as forests, grasslands, deserts, oceans, rivers, and mountains. Some wild animals may come into contact with human populations, particularly in urban areas where their natural habitats have been destroyed or fragmented.

It is important to note that the term "wild" does not necessarily mean that an animal is aggressive or dangerous. While some wild animals can be potentially harmful to humans if provoked or threatened, many are generally peaceful and prefer to avoid contact with people. However, it is essential to respect their natural behaviors and habitats and maintain a safe distance from them to prevent any potential conflicts or harm to either party.

Gamma rays are a type of ionizing radiation that is released from the nucleus of an atom during radioactive decay. They are high-energy photons, with wavelengths shorter than 0.01 nanometers and frequencies greater than 3 x 10^19 Hz. Gamma rays are electromagnetic radiation, similar to X-rays, but with higher energy levels and the ability to penetrate matter more deeply. They can cause damage to living tissue and are used in medical imaging and cancer treatment.

Lentivirus infections refer to the infectious disease caused by lentiviruses, a genus of retroviruses. These viruses are characterized by their ability to cause persistent and long-term infections, often leading to chronic diseases. They primarily target cells of the immune system, such as T-cells and macrophages, and can cause significant immunosuppression.

Lentiviruses have a slow replication cycle and can remain dormant in the host for extended periods. This makes them particularly effective at evading the host's immune response and can result in progressive damage to infected tissues over time.

One of the most well-known lentiviruses is the human immunodeficiency virus (HIV), which causes acquired immunodeficiency syndrome (AIDS). HIV infects and destroys CD4+ T-cells, leading to a weakened immune system and increased susceptibility to opportunistic infections.

Other examples of lentiviruses include simian immunodeficiency virus (SIV), feline immunodeficiency virus (FIV), and equine infectious anemia virus (EIAV). While these viruses primarily infect non-human animals, they are closely related to HIV and serve as important models for studying lentivirus infections and developing potential therapies.

Small interfering RNA (siRNA) is a type of short, double-stranded RNA molecule that plays a role in the RNA interference (RNAi) pathway. The RNAi pathway is a natural cellular process that regulates gene expression by targeting and destroying specific messenger RNA (mRNA) molecules, thereby preventing the translation of those mRNAs into proteins.

SiRNAs are typically 20-25 base pairs in length and are generated from longer double-stranded RNA precursors called hairpin RNAs or dsRNAs by an enzyme called Dicer. Once generated, siRNAs associate with a protein complex called the RNA-induced silencing complex (RISC), which uses one strand of the siRNA (the guide strand) to recognize and bind to complementary sequences in the target mRNA. The RISC then cleaves the target mRNA, leading to its degradation and the inhibition of protein synthesis.

SiRNAs have emerged as a powerful tool for studying gene function and have shown promise as therapeutic agents for a variety of diseases, including viral infections, cancer, and genetic disorders. However, their use as therapeutics is still in the early stages of development, and there are challenges associated with delivering siRNAs to specific cells and tissues in the body.

Cell survival refers to the ability of a cell to continue living and functioning normally, despite being exposed to potentially harmful conditions or treatments. This can include exposure to toxins, radiation, chemotherapeutic drugs, or other stressors that can damage cells or interfere with their normal processes.

In scientific research, measures of cell survival are often used to evaluate the effectiveness of various therapies or treatments. For example, researchers may expose cells to a particular drug or treatment and then measure the percentage of cells that survive to assess its potential therapeutic value. Similarly, in toxicology studies, measures of cell survival can help to determine the safety of various chemicals or substances.

It's important to note that cell survival is not the same as cell proliferation, which refers to the ability of cells to divide and multiply. While some treatments may promote cell survival, they may also inhibit cell proliferation, making them useful for treating diseases such as cancer. Conversely, other treatments may be designed to specifically target and kill cancer cells, even if it means sacrificing some healthy cells in the process.

Up-regulation is a term used in molecular biology and medicine to describe an increase in the expression or activity of a gene, protein, or receptor in response to a stimulus. This can occur through various mechanisms such as increased transcription, translation, or reduced degradation of the molecule. Up-regulation can have important functional consequences, for example, enhancing the sensitivity or response of a cell to a hormone, neurotransmitter, or drug. It is a normal physiological process that can also be induced by disease or pharmacological interventions.

I apologize for any confusion, but "Chile" is not a medical term or concept. It is a country located in South America, known for its long and narrow geography, diverse landscapes, and rich cultural heritage. If you have any questions related to medicine or health, I would be happy to try and help answer those for you.

Caspase-3 is a type of protease enzyme that plays a central role in the execution-phase of cell apoptosis, or programmed cell death. It's also known as CPP32 (CPP for ced-3 protease precursor) or apopain. Caspase-3 is produced as an inactive protein that is activated when cleaved by other caspases during the early stages of apoptosis. Once activated, it cleaves a variety of cellular proteins, including structural proteins, enzymes, and signal transduction proteins, leading to the characteristic morphological and biochemical changes associated with apoptotic cell death. Caspase-3 is often referred to as the "death protease" because of its crucial role in executing the cell death program.

Feline Acquired Immunodeficiency Syndrome (FAIDS) is a progressive immune disorder in cats caused by infection with the feline immunodeficiency virus (FIV). The virus attacks and weakens the cat's immune system, making it difficult for the animal to fight off other infections and diseases.

The initial infection with FIV may cause symptoms such as fever, swollen lymph nodes, and loss of appetite. However, many cats do not show any signs of illness for years after the initial infection. As the immune system becomes weaker over time, the cat becomes more susceptible to various secondary infections, cancers, and other diseases. Common symptoms in advanced stages of FAIDS include weight loss, chronic or recurring infections (such as respiratory, skin, or gastrointestinal infections), dental disease, anemia, and neurological disorders.

FAIDS is most commonly spread through bite wounds from infected cats, as the virus is present in their saliva. It can also be transmitted through sexual contact or from mother to kitten during pregnancy or nursing. There is no cure for FAIDS, but antiretroviral therapy (ART) can help manage the infection and slow down its progression. Supportive care, such as proper nutrition, regular veterinary check-ups, and monitoring for secondary infections, is essential for maintaining the cat's quality of life.

It is important to note that FIV is species-specific and cannot be transmitted from cats to humans or other animals, except non-human primates.

Transcription Factor CHOP, also known as DNA Binding Protein C/EBP Homologous Protein or GADD153 (Growth Arrest and DNA Damage-inducible protein 153), is a transcription factor that is involved in the regulation of gene expression in response to various stress stimuli, such as endoplasmic reticulum (ER) stress, hypoxia, and DNA damage.

CHOP is a member of the C/EBP (CCAAT/enhancer-binding protein) family of transcription factors, which bind to specific DNA sequences called cis-acting elements in the promoter regions of target genes. CHOP can form heterodimers with other C/EBP family members and bind to their target DNA sequences, thereby regulating gene expression.

Under normal physiological conditions, CHOP is expressed at low levels. However, under stress conditions, such as ER stress, the expression of CHOP is upregulated through the activation of the unfolded protein response (UPR) signaling pathways. Once activated, CHOP can induce the transcription of genes involved in apoptosis, cell cycle arrest, and oxidative stress response, leading to programmed cell death or survival, depending on the severity and duration of the stress signal.

Therefore, CHOP plays a critical role in maintaining cellular homeostasis by regulating gene expression in response to various stress stimuli, and its dysregulation has been implicated in several pathological conditions, including neurodegenerative diseases, cancer, and metabolic disorders.

Tunicamycin is not a medical condition or disease, but rather a bacterial antibiotic and a research tool used in biochemistry and cell biology. It is produced by certain species of bacteria, including Streptomyces lysosuperificus and Streptomyces chartreusis.

Tunicamycin works by inhibiting the enzyme that catalyzes the first step in the biosynthesis of N-linked glycoproteins, which are complex carbohydrates that are attached to proteins during their synthesis. This leads to the accumulation of misfolded proteins and endoplasmic reticulum (ER) stress, which can ultimately result in cell death.

In medical research, tunicamycin is often used to study the role of N-linked glycoproteins in various biological processes, including protein folding, quality control, and trafficking. It has also been explored as a potential therapeutic agent for cancer and other diseases, although its use as a drug is limited by its toxicity to normal cells.

... or PUMA may refer to: Puma (genus), a genus in the family Felidae Puma (species) or cougar, a large cat Puma (brand), a ... Puma, American wrestler Puma Jones member of Black Uhuru Puma (village), Solomon Islands Puma (Tanzanian ward) Pumas (Currie ... El Puma, Venezuelan singer and actor Puma King (born 1990), a.k.a. Puma, Mexican wrestler Puma Swede (born 1976), Swedish ... PUMA), geographic units used by the U.S. Census "Puma", a song by TXT from their 2020 EP The Dream Chapter: Eternity Lake Puma ...
... is the largest mortar producer in Spain. The Group consist in more than 20 factories in Spain and Portugal with an ... Access to the Grupo Puma at http://www.grupopuma.com "GRUPO PUMA, S.L. , Construnario". (Manufacturing companies of Spain, ...
... (Aymara puma cougar, puma, sulu shell, husk, "puma shell", Hispanicized spelling Pumasolo) is a 5,015-metre-high ( ...
... (PLV) is a retrovirus. A study in 2003 indicated that domestic cats infected with Puma lentivirus or Lion ... VandeWoude S, Hageman CL, Hoover EA (September 2003). "Domestic cats infected with lion or puma lentivirus develop anti-feline ...
... is an extinct species in genus Puma. It was described based on fossils from the Early Pleistocene-aged Swartkrans ... they were much more similar to members of the genus Puma, and reassigned the subspecies to that genus as a full genus. Puma ... Puma incurva had previously been described in 1956 as an extinct subspecies of leopard under the name Panthera pardus incurva. ... Puma (genus), Fossil taxa described in 1956, Pleistocene carnivorans, Articles needing additional categories from May 2023). ...
Commemorative page (in Spanish) By Roberto Livingston Puma Motorcycle Club in Cordoba (in Spanish) Puma 98 engine modified to 4 ... Puma, pumita, pumarola or pumasaki are the names given to a motorcycle created in Argentina in 1952. It became an emblem of ... "La "Moto Puma"" (in Spanish). Asociación de Amigos del Museo de la Industria. Archived from the original on October 17, 2008. ... The tractors were the Pampa and the Fiat, the Puma motorcycle was manufactured in 100, 125 and 200 cm³ displacement, in several ...
Puma Vehicles fell into bankruptcy in 1985. In 1987 Alfa Metais assumed production of Puma's cars, producing a facelifted GTB ... A prototype named the Puma GTO appeared in 1971. The name was changed to Puma GTB (Gran Turismo Brazil) for the first ... The Puma GTB was a front-engine, rear-wheel-drive touring car based on the Brazilian GM Chevrolet Opala components. ... Registers confirm that the Puma GTB was Brazil's most expensive car from 1973 to 1984. The GTB was powered by a 4100 cc in-line ...
Official website Puma Swede at IMDb Puma Swede at the Internet Adult Film Database Puma Swede at the Adult Film Database (CS1 ... Puma Swede at the Internet Adult Film Database Tripp Daniels. "Puma Swede Inks Deal With Fantasy Girl Entertainment". AVN.com. ... In October 2017, Puma announced that she was opening her first restaurant, "Puma Burger", in Malmö, Sweden. Six months later, ... "Swedish Star Puma Swede Opens Puma Burger Restaurant In Sweden". AVN.com. AVN Media Network. 20 October 2017. Retrieved 18 ...
... (Quechua puma cougar, puma, wacha birth, to give birth, -na a suffix, "where the cougar is born", Hispanicized ... spelling Puma Huachana) is a mountain in Peru, about 5,000 metres (16,404 ft) high. It is located in the Puno Region, Putina ...
"Form S-1". Puma Biotechnology, Inc. via SEC Edgar. December 2, 2011. "Puma Biotech raises $138M in public offering to advance ... Puma Biotechnology is a publicly traded biopharmaceutical company (NASDAQ: PBYI) headquartered in Los Angeles, CA. Puma was ... "Puma Biotechnology Reports Fourth Quarter and Full Year Financial Results". Damouni, Sasha; Tirrell, Meg (12 March 2013). "Puma ... Auerbach brought many Cougar employees with him after founding Puma in 2010. In August 2011 Puma licensed two drug candidates ...
... (Quechua puma cougar, puma, Ancash Quechua wayi house, "cougar house", -n a suffix, also spelled Puma Huain, ... Puma Wayin (Huánuco), a mountain in the Huánuco Region, Peru Puma Wayin (Recuay), a mountain in the Recuay Province, Ancash ... Peru Puma Wayin (Huallanca), a mountain near Ismu Cruz in the Huallanca District, Bolognesi Province, Ancash Region, Peru. ... Peru Puma Wayin (Bolognesi), a mountain near Kunturqucha in the Huallanca District, Bolognesi Province, Ancash Region, ...
... (Quechua puma cougar, rawkha heap, "cougar heap", also spelled Pumarauca) is a mountain in the Cordillera Central ... Puma Rawkha lies northwest of Pukyu Rumi and northeast of Mina Ukru. escale.minedu.gob.pe - UGEL map of the Yauyos Province ( ...
Puma was seen watching the fight between Spider-Man and Scorpion until the Hunter-Bots arrive. Puma was seen fleeing the Hunter ... Puma became enraged at the death of Master Muramoto as the inadvertent result of the Beyonder's actions. Puma reached a state ... Together, Puma and Black Cat neutralize the drunken rampage of the Rhino, mostly through sheer bluffing. Puma also attended ... However, doubting his own senses, Puma lost the mystical power just as he attacked the Beyonder. Puma was able to learn Spider- ...
... (Quechua puma cougar, puma, qaqa rock, "cougar rock", Hispanicized spelling Pumacaca) is a mountain in the Cusco ... Puma Qaqa lies northwest of Chupika. escale.minedu.gob.pe - UGEL map of the Canchis Province (Cusco Region) (unnamed) "Cerro ...
Puma (Puma: पुमा Pumā) is a Kiranti language spoken by about 4,310 people (Central Bureau of Statistics report 2001) in ... The Himalayan Languages Project has produced the first grammatical sketch of Puma. Like other Kiranti languages, Puma has a ... Puma language is taught in 14 schools of Barahapokhari and Jantedhunga Rural Municipalities of Khotang district in Nepal since ... The same term 'Puma' refers both to the people and the language they speak [Sharma 2014]. ...
... is an open source OCR SDK project for the Microsoft Windows platform available under a BSD license. The project is ... Puma.NET is a wrapper for CuneiForm. Project Home Page v t e (Articles with short description, Short description matches ...
The Puma Trophy (Spanish: Trofeo Puma) is an international rugby union competition between Argentina and Australia. The trophy ... The first draw between the two sides since the creation of the Puma Trophy happened in 2020 (15-15). The next meeting - two ... The Wallabies retain the Puma Trophy while Argentina are in party mode with their passionate fans. (Articles needing additional ... is a bronzed statue of a puma. Argentina and Australia first played against each other in 1979 and the trophy itself was ...
Ownership & Stakeholders on Puma Energy (2 Jul 2021) Who we are on Puma Energy website "Puma Energy". www.pumaenergy.com. ... In February 2013 Puma Energy and Castrol formed a new partnership to market Castrol lubricants in all six of Puma's Central ... "KenolKobil, Puma deal seen done in a few months". Reuters. 8 May 2012. Retrieved 17 April 2013. "Oil firm Puma Energy expands ... The Puma brand soon travelled further afield after CGC established Puma service stations in Ecuador, in order to supplement its ...
... and Villano V lost to Axxel and Blue Panther in the opening round of the tournament. In CMLL Puma King and Tiger Kid ... In the finals of Block B Puma King and Último Guerrero were defeated by Delta and Volador Jr. Puma King was one of 12 men who ... He made his wrestling debut in 2006 at the age of just 16, wrestling under the ring name Puma King. Neither Puma King, nor his ... On July 17, 2018, Puma announced his departure from CMLL. On July 22, 2018, Puma made his debut for Lucha Libre AAA Worldwide, ...
... is an extinct prehistoric cat that was described in 1956 by Alfredo Castellanos using the scientific name Felis ... 217−233.{{cite book}}: CS1 maint: location missing publisher (link) Chimento, N. R.; Derguy, M. R.; Hemmer, H. (2014). "Puma ( ... Puma (genus), Prehistoric mammals of South America, Mammals described in 1956, Pliocene carnivorans, Neogene Argentina, All ... it was preliminarily subordinated to the genus Puma. Castellanos, A. (1956). "Nota preliminar sobre nuevos restos de mamíferos ...
The Mowag Puma is one of the armored personnel carriers produced by Mowag based in Switzerland. Emphasized in the Puma vehicles ... The Puma yielded important results for the 8x8 armored personnel carriers weapon carrier Mowag Shark. A prototype of the Puma, ... The Puma was the first of a family of vehicles including the 4x4, 6x6 and 8x8, which were designed and built in the 4x4 and 6x6 ... The 6x6 Puma has steerable wheels on the first and the third axles, while the wheels of the middle axle are fixed, which ...
... (F34), was a Leopard-class anti-aircraft frigate of the Royal Navy, named after the puma (Puma concolor). Envisioned ... Puma was fitted with four QF Mark VI 4.5 guns in two unarmoured twin turrets for anti-aircraft and surface use with remote ... In October 1962, Puma visited Tristan da Cunha, to help to prepare the island for the return of its residents, who had been ... Puma struck a submerged rock while off Tristan da Cuhna, damaging her port propeller, which resulted in the ship being docked ...
The Puma Family 16h is a low-power microarchitecture by AMD for its APUs. It succeeds the Jaguar as a second-generation version ... The Puma cores use the same microarchitecture as Jaguar, and inherits the design: Out-of-order execution and Speculative ... Puma does not feature Heterogeneous System Architecture or zero-copy 32 KiB instruction + 32 KiB data L1 cache per core 1-2 MiB ... the Puma core has support for the following instruction sets and instructions: MMX, SSE, SSE2, SSE3, SSSE3, SSE4a, SSE4.1, ...
... is a line of shoes produced by Puma, with the first model released in 1968. The shoe is notable for being the first ... The Puma Suede would see its in popularity increase in the 1970s when Puma decided to collaborate with basketball player, Walt ... about.puma.com/en/this-is-puma/archive-stories/history-of-suede https://www.soleretriever.com/news/articles/end-x-puma-clyde-og ... Puma decided to create a shoe to change the idea of what a sneaker would look like. The sneaker was designed by Heiko Desens ...
... , sometimes called the Eurasian puma or Owen's panther, is an extinct prehistoric cat. It was long regarded as a ... However, research in 2004 concluded that Viretailurus should actually be included in the genus Puma as a junior synonym of Puma ... ISBN 0-231-10229-1. Hemmer, H.; Kahlike, R. D.; Vekua, A. K. (2004). "The Old World puma Puma pardoides (Owen, 1846) (Carnivora ... until teeth found at the Upper Pliocene Transcaucasian site of Kvabebi were found to be similar to those of pumas. Puma ...
Puma Puñuna (Quechua puma cougar, puñuna bed, "cougar bed", -n a suffix, also spelled Pumapununan) is a mountain in the ...
... (Quechua puma cougar, ranra stony place, Hispanicized spellings Poma Ranra, Pomarangra, Pomaranra, Puma Rangra, ... Peru Puma Ranra (Condesuyos), a mountain in the Condesuyos Province, Arequipa Region, Peru Puma Ranra (Lima), a mountain in the ... Pumarangra, erroneously also Pumrangra) may refer to: Puma Ranra (Castilla-Condesuyos), a mountain on the border of the ... Lima Region, Peru This disambiguation page lists articles associated with the title Puma Ranra. If an internal link led you ...
... is an association football team from Pago Pago, American Samoa. They play in the territory's top division, the FFAS ...
Maps of Vanikoro, showing location of Puma on Teanu island. Satellite photo of Puma village. 11°36′47.9″S 166°58′9.8″E /  ... Puma is the only inhabited village of the island of Teanu, in the Vanikoro group located in the Solomon Islands. The language ... spoken there has been sometimes referred to as Puma (or wrongly Buma), and is now known as Teanu. "Teanu: A language of Solomon ...
... originally intended to be called the Puma 1997-2002 Ford Puma sport compact 2019-present Ford Puma crossover "Escort Mk1 RS2000 ... The Ford Puma is a nameplate used by Ford Motor Company for several car models. The "Puma" name is also used on variants of the ... Ford Puma (sport compact), a 1997-2001 sport compact car Ford Puma (crossover), a 2019-present subcompact crossover SUV Ford ... Puma Rally1, a 2022 Rally1 car built by the M-Sport Ford World Rally Team Ford Duratorq ZSD "Puma", a line of 2.0-litre, 2.2- ...
Puma or PUMA may refer to: Puma (genus), a genus in the family Felidae Puma (species) or cougar, a large cat Puma (brand), a ... Puma, American wrestler Puma Jones member of Black Uhuru Puma (village), Solomon Islands Puma (Tanzanian ward) Pumas (Currie ... El Puma, Venezuelan singer and actor Puma King (born 1990), a.k.a. Puma, Mexican wrestler Puma Swede (born 1976), Swedish ... PUMA), geographic units used by the U.S. Census "Puma", a song by TXT from their 2020 EP The Dream Chapter: Eternity Lake Puma ...
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  • Available in metallic silver or black and white, the Fenty x Puma Avanti sneakers feature a foldover tongue, a gum outsole, and a leather footbed, finished off by gold embossed details. (yahoo.com)
  • Shopping the Fenty x Puma Avanti sneakers is as simple as visiting Puma's website, where they're currently on sale. (yahoo.com)
  • Grab a pair of the new Avanti sneakers from Fenty x Puma below. (yahoo.com)
  • Puma sneakers provide a leather footbed, rubber console, and textile lining - all that give you support and stability. (talkradionews.com)
  • you can wear Puma sneakers with ease! (talkradionews.com)
  • Customers love walking with Puma Sneakers. (talkradionews.com)
  • Puma sneakers are breathable, allowing your feet to relax while you walk. (talkradionews.com)
  • Among the unisex sneakers, the Smash V2 low-top Puma Sneakers have been one of the best-sellers for a few years. (talkradionews.com)
  • Rihanna and Puma are teaming up once again to bring you the latest installment of Fenty x Puma , the sporty fashion collaboration headed up by the global superstar. (yahoo.com)
  • Rihanna and Puma eventually launched the Fenty x Puma collection, which started with a sneaker (the Creepers, for those who are wondering). (yahoo.com)
  • PUMA, sharing the same passion for innovation and progress, has been the officiel supplier of the Tag Heuer Formula E team performance racewear since 2019. (porsche.com)
  • I studied International Marketing & Brand Management at LUSEM (2018-2019) and currently work as a Senior Marketplace Manager at the European Ecommerce Team of Puma. (lu.se)
  • PUMA - pooled uranium miners analysis: cohort profile. (lu.se)
  • The PUMA Stewie 2 "Water" releases for $125 on August 4, 2023, at PUMA.com , the PUMA NYC flagship store, the PUMA mobile app, and select retailers. (nicekicks.com)
  • To celebrate its 75th anniversary, PUMA has entered the Creators Lab to produce a dazzling limited edition collection that unites the dynamic worlds of sportswear and luxury. (swarovski.com)
  • Known for combining its rich history with a commitment to quality, ingenuity, and innovation, PUMA is an elevated sportswear brand with exceptional style sensibilities. (swarovski.com)
  • Now, one of the leading sportswear brands, Puma, has started its journey in Germany. (talkradionews.com)
  • International sportswear manufacturer, Puma, has snapped up a 20-percent stake worth P185 million in Botswana's tourism concern Wilderness Holdings through a private placement. (mmegi.bw)
  • According to the latest, Rihanna and Puma may be collaborating on a new sneaker and sportswear collection, and, as she's nearly reached an official agreement with the German brand, reports say the deal is worth $1 million. (globalgrind.com)
  • The Ford Puma looks an interesting package for buyers in the small SUV segment searching for something a little more fun. (rac.co.uk)
  • You might just remember the Ford Puma - but you won't remember it like this. (rac.co.uk)
  • The Prince of Wales Liga takes the classic PUMA Liga shoe and updates it with the finest fabrics and details. (sneakerfreaker.com)
  • An icon of culture, the original PUMA Suede was a 70's statement shoe, an 80's Hip-Hop must-have and ever present in the alternative music scene of the 1990's.Famous for its bright colours, suede material, and custom lacing techniques, the PUMA Suede now stands for another thing. (packagingdigest.com)
  • Rihanna's partnership with Puma first began in 2015, when she was named the creative director of the Puma Women's division. (yahoo.com)
  • With trailblazing celebrity costume designer June Ambrose as women's basketball creative director, Puma returned to the New York Fashion Week scene. (popsugar.com)
  • Keep your feet protected with Puma women's socks. (talkradionews.com)
  • Taking inspiration from England's famous Saville Row, where customers come to order custom-made clothing, PUMA's Bespoke collection in conjunction with Oki-ni, takes iconic styles from the PUMA Archive and re-interprets them in the spirit of Britain's luxurious Bespoke tradition. (sneakerfreaker.com)
  • Puma's logo displays a fierce puma jumping ahead, and the brand - just like its logo - takes the long leap towards its motive to succeed. (talkradionews.com)
  • The 164m 2 Puma Midlands Store features the global sports brand's latest Forever Faster store concept. (bizcommunity.com)
  • The brand noted that its Forever Faster store concept enables Puma to showcase products in a retail environment that inspires customers and invites them to engage with the brand. (bizcommunity.com)
  • Here at PUMA Australia, in our Melbourne support office, we have a team of 85 team members giving their all to drive our exciting brand Forever Faster! (puma.com)
  • These new kicks bring Puma and Hussein Chalayan together to make a sneaker so fly, it has wings. (maxim.com)
  • PUMA is one of the world's leading Sports Brands, designing, developing, selling and marketing footwear, apparel and accessories. (gulesider.no)
  • Streetwear chic takes on exhilarating new dimensions with the crystallized PUMA Hoodie. (swarovski.com)
  • This hoodie emerges as part of PUMA and Noah's latest collection in a monochrome gray colorway with contrasting lining at the hood. (highsnobiety.com)
  • Based on the iconic Archive T7 track jacket, the PUMA Jacket uses only the finest English wool-twill sourced in Saville Row by Bespoke tailors, Ravi Tailor & AJ Hewitt. (sneakerfreaker.com)
  • Fresh off the success of her viral High Court collection , she built on her customers' growing appetite for stylish pieces, riffing on Puma house codes and reimagining iconic silhouettes like the T7 tracksuits. (popsugar.com)
  • Its design is simple - the 3 iconic stripes and a fierce Puma on the sides. (talkradionews.com)
  • PUMA took one of the Brand's most well-known and iconic shoes, the Suede, and re-tooled each component with the highest degree of recycled materials, delivering sustainable style through an unforgettable look. (packagingdigest.com)
  • Wherever you're heading, travel in style with our collection of men's Puma bags this season. (houseoffraser.co.uk)
  • The classic PUMA Suede will be recreated in the Bespoke tradition by Loake in Northamptonshire, the traditional heart of English shoemaking. (sneakerfreaker.com)
  • Sportlifestyle company PUMA introduces PUMA Re-Suede. (packagingdigest.com)
  • The PUMA Re-Suede has been developed using the latest materials and processes in eco-friendly product innovation. (packagingdigest.com)
  • Additionally, the PUMA Re-Suede outsole is made from Double R Rice Rubber, which replaces a portion of the rubber content with a rice husk filler, reducing the overall rubber needed, and saving considerable fossil fuel energy in manufacturing and agricultural resources. (packagingdigest.com)
  • For over 70 years, PUMA has relentlessly pushed sport and culture forward by creating fast products for the world's fastest athletes. (gulesider.no)
  • After a nearly two-decade hiatus, PUMA and the NBA have announced a new multi-year marketing agreement between the German apparel giants and the world's premier basketball league. (sportsagentblog.com)
  • Color Puma White/Puma Black/Metallic Silver. (zappos.com)
  • Thanks to its fashionable urban outlook and budget-friendly prices, customers often choose Puma rather than Adidas or Nike. (talkradionews.com)
  • Squiggly sea creatures and stained glass window prints, SWASH and PUMA team up for an SS16 collaboration. (wonderlandmagazine.com)
  • Designed for Fall/Winter 2016 collection, the Giaguaro Puma is an ultra-classic model, combining a unique metal bridge and carefully carved acetate structure into a casual, sophisticated silhouette. (retrosuperfuture.com)
  • PUMA Hoops and New York Liberty's Breanna Stewart have the third PUMA Stewie 2 colorway on the forecast with the upcoming PUMA Stewie 2 "Water" colorway. (nicekicks.com)
  • We couldn't find any results for puma cali nubuck. (zappos.com)
  • By providing quality at such a reasonable price, Puma smashes the impression. (talkradionews.com)
  • Each piece in the collection combines the integrity of the classic PUMA design with the finest fabrics and leathers. (sneakerfreaker.com)
  • The Bespoke collection will be available exclusively for purchase at oki-ni on-line, at a guerilla store in London and the PUMA Black Store in New York's meatpacking district beginning September 2007. (sneakerfreaker.com)
  • PUMA will adopt the SWASH pair, Sarah Swash and Toshio Tamanaka's usual methods, creating fantasy worlds, reaching impressive new heights in a streetwear collection. (wonderlandmagazine.com)
  • PUMA offers performance and sport-inspired lifestyle products in categories such as Football, Running and Training, Basketball, Golf, and Motorsports. (gulesider.no)
  • Here, we shall review some of the best-selling Puma products that make it a famous brand. (talkradionews.com)
  • Brazilian football star, Neymar Jr., has signed a long-term partnership deal with sportwear company PUMA. (sportsagentblog.com)
  • There is a broad variety of companies there - I personally decided to start a position in the european Ecommerce Team at PUMA again as I knew the company very well due to an internship I did before. (lu.se)
  • With both Puma ST derivatives, an optimised chassis features bespoke twist-beam, anti-roll bar and damper configurations. (rac.co.uk)
  • After steaming and hand brushing, the cap is finished off with a hand embroidered PUMA Cat Logo onto the front by Hand & Lock, a traditional Saville Row embroiderer which has been using bespoke services for over 200 years. (sneakerfreaker.com)
  • Explore the most appealing deals available for Hotel Puma, ensuring you get the best value for your stay. (hotelscombined.com)
  • PUMA Golf - Ignite Articulate Disc Golf Shoes. (zappos.com)
  • PUMA Golf - Proadapt Alphacat Disc Golf Shoes. (zappos.com)
  • PUMA Golf - Ignite Pwrcage (Little Kid/Big Kid) Golf Shoes. (zappos.com)
  • Puma breaks the myth that the best shoes need to be expensive. (talkradionews.com)
  • Not only its shoes, but customers also love other Puma accessories too. (talkradionews.com)
  • Puma always shows that great shoes do not need big bucks. (talkradionews.com)
  • Like the original Puma, it's based on Fiesta engineering and is primarily powered by the mild hybrid 1.0-litre EcoBoost petrol engine the Blue Oval brand has also ear-marked for that supermini. (rac.co.uk)
  • But since the success of Puma High Court , there's a confidence in the brand, knowing that they can speak in this style space. (popsugar.com)
  • Is Puma A Good Brand? (talkradionews.com)
  • One such brand is Puma. (talkradionews.com)
  • Global Sports Brand PUMA collaborates anew with the East London based print and fashion house SWASH London. (wonderlandmagazine.com)
  • Whether it's developing on-field kits for our teams, driving our retail business growth or coming up with the next amazing PUMA marketing campaign, we all pull together to make this brand everything that it can be. (puma.com)
  • Slightly oversized, with a relaxed fit that reflects the athleisure aesthetic, this all-black piece features the PUMA No. 1 logo, meticulously adorned with archive green Swarovski crystals. (swarovski.com)
  • Puma pricing reflects current figures at the upper end of the small SUV segment - which Ford feels justified in asking given this car's relatively sophisticated mild hybrid tech. (rac.co.uk)
  • The Puma Midlands Store is located at shop no. 106 at the Midlands Mall, 50 Sanctuary Road, Pietermaritzburg. (bizcommunity.com)
  • Older version of the hawk2 package were shipped with older versions of puma which did not have the ability to disable TLS versions 1.0 and 1.1. (suse.com)
  • Discover essential information, amenities, and features of Hotel Puma, providing insights into what to expect during your stay. (hotelscombined.com)
  • The alternative non-hybrid engine is the 1.5-litre EcoBoost 200PS unit that features in the top Puma ST Permance model. (rac.co.uk)
  • PUMAS offers solutions to urban mobility challenges by co-ordinating the development of SUMPs in the Alpine Space. (eltis.org)
  • puma also offers improvements in terms of scope and speed of execution over previously available uncertainty propagation methods. (bioconductor.org)
  • Color Puma Black/Cool Mid Gray. (zappos.com)
  • Color Puma Black/Puma Silver/Quiet Shade. (zappos.com)
  • Color PUMA Black/Leather Brown. (zappos.com)
  • Choose from various colourways in black, blue, white, grey and more featuring the signature Puma branding. (houseoffraser.co.uk)
  • The PUMA Group owns the brands PUMA, Cobra Golf and stichd. (gulesider.no)
  • POPSUGAR: What an exciting time for Puma! (popsugar.com)
  • For the first time, the puma package makes a suite of uncertainty propagation methods available to a general audience. (bioconductor.org)
  • Puma will be hoping Conte decided to give the Spaniard some significant pitch time against his former club, but that doesn't mean we can't enjoy the boots for the time being. (soccerpro.com)
  • PUMA has been recognized as a Top Employer in Australia for dedication to provide the best working environment for employees through progressive "people-first" HR practices - for the second time in a row. (puma.com)
  • Puma Seed bed cultivator is designed to work with light and heavy soils. (cerealsevent.co.uk)
  • At PUMA Australia, we provide an environment where you can be the best you and do your best work. (puma.com)
  • We foster a flexible and progressive workplace philosophy born from our PUMA DNA, with remote work options, a generous 14-week paid parental leave program along with a keen focus on personal and professional development. (puma.com)
  • Work hard, play hard at PUMA Australia. (puma.com)
  • Fresh off a set of results that seems to say that the Arsenal vs Chelsea match-up might have a bit less of an impact on the race to the title, we want to take a dive into how Puma plans to make the fixture special for two players and for any fan of boots. (soccerpro.com)
  • The lining is English calf leather with a silver PUMA/Oki-no logo in the sock liner. (sneakerfreaker.com)
  • Discover other properties in Rio de Janeiro that offer a similar experience and ambiance to Hotel Puma. (hotelscombined.com)
  • The PUMA Cat Logo Cap was developed by Walter Wright, who has been making felt and straw hats for over 100 years. (sneakerfreaker.com)
  • Everyone's favorite bad girl is about to bless us with a new album, but in addition to creating the music we'll probably be fist-pumping to for years to come, RiRi is teaming up with Puma, which is prepared to pay her handsomely for her celebrity influence. (globalgrind.com)
  • The PUMA designation grants the manufacturer 10 years of market protection. (medscape.com)