Pulmonary Emphysema: Enlargement of air spaces distal to the TERMINAL BRONCHIOLES where gas-exchange normally takes place. This is usually due to destruction of the alveolar wall. Pulmonary emphysema can be classified by the location and distribution of the lesions.Emphysema: A pathological accumulation of air in tissues or organs.Pancreatic Elastase: A protease of broad specificity, obtained from dried pancreas. Molecular weight is approximately 25,000. The enzyme breaks down elastin, the specific protein of elastic fibers, and digests other proteins such as fibrin, hemoglobin, and albumin. EC 3.4.21.36.alpha 1-Antitrypsin Deficiency: Deficiency of the protease inhibitor ALPHA 1-ANTITRYPSIN that manifests primarily as PULMONARY EMPHYSEMA and LIVER CIRRHOSIS.Subcutaneous Emphysema: Presence of air or gas in the subcutaneous tissues of the body.alpha 1-Antitrypsin: Plasma glycoprotein member of the serpin superfamily which inhibits TRYPSIN; NEUTROPHIL ELASTASE; and other PROTEOLYTIC ENZYMES.Lung: Either of the pair of organs occupying the cavity of the thorax that effect the aeration of the blood.Matrix Metalloproteinase 12: A secreted matrix metalloproteinase which is highly expressed by MACROPHAGES where it may play a role in INFLAMMATION and WOUND HEALING.Pulmonary Alveoli: Small polyhedral outpouchings along the walls of the alveolar sacs, alveolar ducts and terminal bronchioles through the walls of which gas exchange between alveolar air and pulmonary capillary blood takes place.Mediastinal Emphysema: Presence of air in the mediastinal tissues due to leakage of air from the tracheobronchial tree, usually as a result of trauma.Respiratory Function Tests: Measurement of the various processes involved in the act of respiration: inspiration, expiration, oxygen and carbon dioxide exchange, lung volume and compliance, etc.SmokeHelium: Helium. A noble gas with the atomic symbol He, atomic number 2, and atomic weight 4.003. It is a colorless, odorless, tasteless gas that is not combustible and does not support combustion. It was first detected in the sun and is now obtained from natural gas. Medically it is used as a diluent for other gases, being especially useful with oxygen in the treatment of certain cases of respiratory obstruction, and as a vehicle for general anesthetics. (Dorland, 27th ed)Pulmonary Disease, Chronic Obstructive: A disease of chronic diffuse irreversible airflow obstruction. Subcategories of COPD include CHRONIC BRONCHITIS and PULMONARY EMPHYSEMA.Pneumonectomy: The excision of lung tissue including partial or total lung lobectomy.Vasculitis, Leukocytoclastic, Cutaneous: Disorder characterized by a vasculitic syndrome associated with exposure to an antigen such as a drug, infectious agent, or other foreign or endogenous substance. Its pathophysiology includes immune complex deposition and a wide range of skin lesions. Hypersensitivity or allergy is present in some but not all cases.ElastinPanniculitis: General term for inflammation of adipose tissue, usually of the skin, characterized by reddened subcutaneous nodules.Smoking: Inhaling and exhaling the smoke of burning TOBACCO.Tomography, X-Ray Computed: Tomography using x-ray transmission and a computer algorithm to reconstruct the image.Bronchoalveolar Lavage Fluid: Washing liquid obtained from irrigation of the lung, including the BRONCHI and the PULMONARY ALVEOLI. It is generally used to assess biochemical, inflammatory, or infection status of the lung.Forced Expiratory Volume: Measure of the maximum amount of air that can be expelled in a given number of seconds during a FORCED VITAL CAPACITY determination . It is usually given as FEV followed by a subscript indicating the number of seconds over which the measurement is made, although it is sometimes given as a percentage of forced vital capacity.Pulmonary Fibrosis: A process in which normal lung tissues are progressively replaced by FIBROBLASTS and COLLAGEN causing an irreversible loss of the ability to transfer oxygen into the bloodstream via PULMONARY ALVEOLI. Patients show progressive DYSPNEA finally resulting in death.Lung Compliance: The capability of the LUNGS to distend under pressure as measured by pulmonary volume change per unit pressure change. While not a complete description of the pressure-volume properties of the lung, it is nevertheless useful in practice as a measure of the comparative stiffness of the lung. (From Best & Taylor's Physiological Basis of Medical Practice, 12th ed, p562)Pneumonia: Infection of the lung often accompanied by inflammation.Disease Models, Animal: Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.Lung Diseases: Pathological processes involving any part of the LUNG.Bronchi: The larger air passages of the lungs arising from the terminal bifurcation of the TRACHEA. They include the largest two primary bronchi which branch out into secondary bronchi, and tertiary bronchi which extend into BRONCHIOLES and PULMONARY ALVEOLI.Mice, Inbred C57BLTobacco: A plant genus of the family SOLANACEAE. Members contain NICOTINE and other biologically active chemicals; its dried leaves are used for SMOKING.Cough: A sudden, audible expulsion of air from the lungs through a partially closed glottis, preceded by inhalation. It is a protective response that serves to clear the trachea, bronchi, and/or lungs of irritants and secretions, or to prevent aspiration of foreign materials into the lungs.Lung Diseases, Obstructive: Any disorder marked by obstruction of conducting airways of the lung. AIRWAY OBSTRUCTION may be acute, chronic, intermittent, or persistent.PubMed: A bibliographic database that includes MEDLINE as its primary subset. It is produced by the National Center for Biotechnology Information (NCBI), part of the NATIONAL LIBRARY OF MEDICINE. PubMed, which is searchable through NLM's Web site, also includes access to additional citations to selected life sciences journals not in MEDLINE, and links to other resources such as the full-text of articles at participating publishers' Web sites, NCBI's molecular biology databases, and PubMed Central.Periodicals as Topic: A publication issued at stated, more or less regular, intervals.BooksInternal Medicine: A medical specialty concerned with the diagnosis and treatment of diseases of the internal organ systems of adults.Evidence-Based Medicine: An approach of practicing medicine with the goal to improve and evaluate patient care. It requires the judicious integration of best research evidence with the patient's values to make decisions about medical care. This method is to help physicians make proper diagnosis, devise best testing plan, choose best treatment and methods of disease prevention, as well as develop guidelines for large groups of patients with the same disease. (from JAMA 296 (9), 2006)Weight Gain: Increase in BODY WEIGHT over existing weight.Air Sacs: Thin-walled sacs or spaces which function as a part of the respiratory system in birds, fishes, insects, and mammals.SkatoleVeterinary Medicine: The medical science concerned with the prevention, diagnosis, and treatment of diseases in animals.Hypertension, Pulmonary: Increased VASCULAR RESISTANCE in the PULMONARY CIRCULATION, usually secondary to HEART DISEASES or LUNG DISEASES.Syndrome: A characteristic symptom complex.Pulmonary Medicine: A subspecialty of internal medicine concerned with the study of the RESPIRATORY SYSTEM. It is especially concerned with diagnosis and treatment of diseases and defects of the lungs and bronchial tree.Dyspnea: Difficult or labored breathing.Spirometry: Measurement of volume of air inhaled or exhaled by the lung.Telepathology: Transmission and interpretation of tissue specimens via remote telecommunication, generally for the purpose of diagnosis or consultation but may also be used for continuing education.Urology: A surgical specialty concerned with the study, diagnosis, and treatment of diseases of the urinary tract in both sexes, and the genital tract in the male. Common urological problems include urinary obstruction, URINARY INCONTINENCE, infections, and UROGENITAL NEOPLASMS.Bronchitis, Chronic: A subcategory of CHRONIC OBSTRUCTIVE PULMONARY DISEASE. The disease is characterized by hypersecretion of mucus accompanied by a chronic (more than 3 months in 2 consecutive years) productive cough. Infectious agents are a major cause of chronic bronchitis.Bronchitis: Inflammation of the large airways in the lung including any part of the BRONCHI, from the PRIMARY BRONCHI to the TERTIARY BRONCHI.Nephrology: A subspecialty of internal medicine concerned with the anatomy, physiology, and pathology of the kidney.
Fragile lung in the Marfan syndrome. (1/1021)
Two cases of the Marfan syndrome presented with spontaneous pneumothorax. Both had chest radiographs showing bilateral bullae in the upper lung zones and pulmonary function tests consistent with mild emphysema. There were dereases in forced expiratory flow rates at low lung volumes, carbon monoxide transfer factor, and lung elastic recoil. It is suggested that pneumothorax and bullous emphysema in this syndrome are caused by a weakness in the pulmonary connective tissue framework. (+info)Detection of anti-cytokeratin 8 antibody in the serum of patients with cryptogenic fibrosing alveolitis and pulmonary fibrosis associated with collagen vascular disorders. (2/1021)
BACKGROUND: It has been suggested that the humoral immune system plays a role in the pathogenesis of cryptogenic fibrosing alveolitis (CFA). Although circulating autoantibodies to lung protein(s) have been suggested, none of the lung proteins have been characterised. The purpose of this study was to determine the antigen to which the serum from patients with pulmonary fibrosis reacted. METHODS: The anti-A549 cell antibody was characterised in a patient with CFA using Western immunoblotting and immunohistochemical staining of A549 cells. As we identified that one of the antibodies against A549 cells was anti-cytokeratin 8, the expression of mRNA of cytokeratin 8 in A549 cells was evaluated. In addition, we attempted to establish an enzyme linked immunosorbent assay to measure the levels of anti-cytokeratin 8 antibody in the serum of patients with CFA and pulmonary fibrosis associated with collagen vascular disorders (PF-CVD). RESULTS: Initially two anti-A549 cell antibodies were detected in the serum of patients with pulmonary fibrosis, one of which was characterised as anticytokeratin 8 antibody by Western immunoblotting. We were able to establish an ELISA to measure anti-cytokeratin 8 antibody and found significantly higher levels in patients with CFA and PF-CVD than in normal volunteers, patients with sarcoidosis, pneumonia, and pulmonary emphysema. CONCLUSIONS: One of the anti-A549 cell antibodies in the serum of patients with CFA was against cytokeratin 8. The serum levels of anti-cytokeratin 8 antibody were increased in patients with CFA and PF-CVD. These results suggest that anticytokeratin 8 antibody may be involved in the process of lung injury in pulmonary fibrosis. (+info)Improvements in thoracic movement following lung volume reduction surgery in patients with severe emphysema. (3/1021)
In twelve patients with severe emphysema who underwent lung volume reduction surgery (LVRS), we assessed the results of dyspnea scale, pulmonary function, 6-minute walk distance (6MD), and thoracic movement prior to and 6 months following LVRS. Postoperatively, forced expiratory volume (FEV1), maximum inspiratory mouth pressures (MIP), maximum expiratory mouth pressures (MEP), maximum voluntary ventilation (MVV), diffusing capacity for carbon monoxide (DLCO), partial pressure of oxygen (PaO2) and 6MD were significantly increased with the decrease in dyspnea scale and lung hyperinflation. Thoracic movement, as assessed by the bilateral lung area ratio of the mid-sagittal dimension of dynamic magnetic resonance imaging (MRI) at full inspiration to that at full expiration, was significantly increased. The improvement in thoracic movement was significantly correlated with the increases in FEV1, MVV, and MIP, and with the decrease in residual volume (RV), and with the improvement in the dyspnea scale. These findings suggest that LVRS is an effective procedure for improving not only the airflow limitation and gas exchange but also the thoracic movement in severe emphysema, and these improvements may contribute to an increase in exercise performance and relief of dyspnea. (+info)Physiological basis of improvement after lung volume reduction surgery for severe emphysema: where are we? (4/1021)
Lung volume reduction surgery has become an accepted therapeutic option to relieve the symptoms of selected patients with severe emphysema. In a majority of these patients, it causes objective as well as subjective functional improvement. A proper understanding of the physiological determinants underlying these beneficial effects appears very important in order to better select patients for the procedure that is currently largely carried out on an empirical basis. Lung volume reduction surgery has two distinct effects. Firstly, it causes an increased elastic recoil, which at least partially explains the enhanced maximal expiratory flow. Secondly, it is associated with a reduction of hyperinflation which allows for an increase in global inspiratory muscle strength and in diaphragmatic contribution to tidal volume as well as a decrease in the inspiratory elastic load imposed by the chest wall. Taken together, these effects result in a reduced work of breathing and in an enhanced maximal ventilation which both contribute to the increased exercise capacity and reduced dyspnoea after surgery. The improved lung recoil and the reduced hyperinflation after volume reduction surgery were the primary postulates upon which the usual selection criteria for the procedure were based. It is now likely that these are correct. Nevertheless, some patients do not benefit from lung volume reduction surgery and the current literature does not allow for a refinement of the selection process from a physiological point of view. The exact mechanisms underlying the improvement in lung recoil, lung mechanics, and respiratory muscle function remain incompletely understood. Moreover, the effects of lung volume reduction surgery on gas exchange and pulmonary haemodynamics still need to be more fully investigated. An analysis of the characteristics of patients who do not benefit from the procedure and the development of an animal model for lung volume reduction surgery would probably help address these important issues. (+info)Subjective differentiation of normal and pathological bronchi on thin-section CT: impact of observer training. (5/1021)
The effect of observer training on sensitivity, specificity and interobserver agreement in the differentiation between normal and pathological bronchi on computed tomography (CT) was studied. The wall thickness of bronchi with normal walls and with pathologically thickened walls were subjectively scored by three independent observers before and after a training period of 2 weeks. Sensitivity, specificity and interobserver agreement were calculated for reading sessions before and after training. Increase and decrease in agreement after training were determined. There was a statistically significant difference (p=0.001) between objectively measured wall thickness of normal and pathological bronchi, both for reference bronchi and for bronchi used for reading sessions. While training increased interobserver agreement, it had no effect on sensitivity (0.46 versus 0.44 after training) and specificity (0.71 versus 0.72 after training) in detecting pathological bronchi. Increased agreement after training was significantly (p=0.001) more frequent than decreased agreement. There is a discrepancy between the effect of training on interobserver agreement and on sensitivity and specificity in the subjective differentiation between normal and pathological bronchi. Interobserver agreement alone is not a reliable indicator of a beneficial effect of training in the evaluation of this parameter. (+info)Outcome of asthma: longitudinal changes in lung function. (6/1021)
Current knowledge about factors determining outcome of asthma is limited, but observations over the last few decades suggest that active asthma has a negative impact on the longitudinal changes in lung function. This review aims to give an overview of the present knowledge concerning longitudinal changes in lung function, including clinical markers for distinctly poor outcome with regard to lung function, in children and adults suffering from asthma. The majority of patients with asthma have a good prognosis. However, some patients with asthma, especially those with more severe disease, are at risk of impaired growth of lung function during childhood, a lower maximally attained level of lung function and excessive decline in lung function in adulthood, which may lead to life-threatening lung function impairment. Clinical markers of poorly controlled airway inflammation appear to have a negative impact on the longitudinal changes in lung function, and disease progression to nonreversible airflow obstruction may be observed in a minority of patients with asthma. Early intervention with anti-inflammatory therapy may improve the short-term outcome of asthma, but long-term controlled studies are clearly needed in order to verify whether or not treatment, especially with inhaled corticosteroids, according to the current international guidelines alters the natural history of asthma, i.e. disease progression with regard to changes in lung function and possible development of nonreversible airflow obstruction. (+info)Surgical aspects and techniques of lung volume reduction surgery for severe emphysema. (7/1021)
Lung volume reduction surgery (LVRS) has become an accepted procedure for palliative treatment of diffuse, nonbullous emphysema. Single or multiple peripheral segmental wedge resections of the most destroyed areas of the lungs are performed with the use of stapling devices, in order to decrease hyperinflation and restore diaphragmatic function. Median sternotomy, videoendoscopy or anterior muscle sparing thoracotomies have been used as surgical approaches. The functional improvement after bilateral resections exceed those after a unilateral approach. LVRS has demonstrated its potential as an alternative to transplantation, and with growing experience, the indications for the procedure have been widened. In selected patients with peripheral lung cancer who have been considered unsuitable for a surgical resection, the combination of both tumour resection and LVRS has successfully been performed. In contrast to LVRS, laser surgery of the emphysematous lung has been abandoned in most institutions. (+info)Emphysematous lesions, inflammation, and fibrosis in the lungs of transgenic mice overexpressing platelet-derived growth factor. (8/1021)
Because of its expression pattern and its potent effects on mesenchymal cells, platelet-derived growth factor (PDGF) has been implicated as an important factor in epithelial-mesenchymal cell interactions during normal lung development and in the pathogenesis of fibrotic lung disease. To further explore the role of PDGF in these processes, we have developed transgenic mice that express the PDGF-B gene from the lung-specific surfactant protein C (SPC) promoter. Adult SPC-PDGFB transgenic mice exhibited lung pathology characterized by enlarged airspaces, inflammation, and fibrosis. Emphysematous changes frequently occurred throughout the lung, but inflammation and fibrotic lesions were usually confined to focal areas. The severity of this phenotype varied significantly among individual mice within the same SPC-PDGFB transgenic lineage. A pathology similar to that observed in adult mice was noted in lungs from transgenic mice as young as 1 week of age. Neonatal transgenic mice exhibited enlarged saccules and thickened primary septa. Results of these studies indicated that overexpression of PDGF-B induced distinct abnormalities in the developing and adult lung and led to a complex phenotype that encompassed aspects of both emphysema and fibrotic lung disease. (+info)
Centrilobular emphysema | Article about centrilobular emphysema by The Free Dictionary
Paediatria Croatica - Congenital lobar emphysema - case report
Congenital lobar emphysema
Congenital lobar emphysema definition | Drugs.com
The Effect and Mechanism of Bronchoscopic Lung Volume Reduction by Endobronchial Valve in Korean Emphysema Patients - Full Text...
BioGlue and Peri-strips in lung volume reduction surgery: pilot randomised controlled trial | Journal of Cardiothoracic Surgery...
Lobar Emphysema 1 (Differential Diagnosis RDS) - Pediatric Surgery
Lung Reduction Surgery Risky For Certain Emphysema Patients - Columbia University Medical Center
Circulating endothelial stem cells are not decreased in pulmonary emphysema or COPD | Thorax
An Outline of Pulmonary Function and Pulmonary Emphysema. | Annals of Internal Medicine | American College of Physicians
Three Cases of ALCAPA with Associated Anomalies
Congenital Lobar Emphysema - The Clinical Advisor
Panacinar emphysema | Define Panacinar emphysema at Dictionary.com
Netherlands 10 mL Bronchoscopic Lung Volume Reduction (BLVR) Phase 1/2 Emphysema Study - Initial Formulation - Full Text View -...
Assessment of multislice CT to quantify pulmonary emphysema function and physiology in a rat model<...
JAIRO | Evaluation of cigarette smoke-induced emphysema in mice using quantitative micro-computed tomography(審査報告)
National Emphysema Treatment Trial (NETT) | National Heart, Lung, and Blood Institute (NHLBI)
Pulmonary Emphysema. | Annals of Internal Medicine | American College of Physicians
Pulmonary emphysema, CT scan - Stock Image C021/2971 - Science Photo Library
Pulmonary emphysema, X-ray - Stock Image C021/2974 - Science Photo Library
Parenchymal, bronchiolar, and bronchial measurements in centrilobular emphysema | Thorax
Lobar emphysema: long-term imaging follow-up. - MyScienceWork
Pulmonary Interstitial Emphysema Clinical Presentation: History and Physical Examination
Risk factors and clinical outcomes of pulmonary interstitial emphysema in extremely low birth weight infants.
Evaluation of cigarette smoke-induced emphysema in mice using quantitative micro-computed tomography<...
Comparison of lung volume reduction surgery and physical training on health status and physiologic outcomes - A randomized...
Lung Volume Reduction Surgery for Chronic Obstructive Pulmonary Disease (COPD) | Columbia University Department of Surgery
In vivo estimation of septal lung tissue volume and correlation with diffusing capacity in lung volume reduction surgery [4]<...
Nishiyama, Yoshihiro - OU Author List - OKAYAMA UNIVERSITY SCIENTIFIC ACHIEVEMENT REPOSITORY
Bronchoscopic lung volume reduction | European Respiratory Society
Chronic obstructive pulmonary disease: pulmonary emphysema and chronic bronchitis | Body Diseases
Pulmonary Emphysema
Touro | Pulmonary Emphysema
IJERPH | Free Full-Text | Cross-Sectional Analysis of the Utility of Pulmonary Function Tests in Predicting Emphysema in Ever...
Long-term Spa Therapy Prevents the Progressive Pathological Changes of the lung in Patients with Pulmonary Emphysema.
-...
Pulmonary emphysema (COPD). Pulmonology: Diagnostic in Germany, Duesseldorf hospitals on BookingHealth.com
Pulmonary emphysema (COPD). Pulmonology: Diagnostic in Switzerland, Winterthur hospitals on BookingHealth.com
Pulmonary Emphysema Royalty Free Stock Image - Image: 22050446
Severity analysis of pulmonary emphysema based on the comparison of expiratory and inspiratory states - Fingerprint
- Keio...
Pulmonary emphysema
Acute Bovine Pulmonary Emphysema and Edema - Respiratory System - Merck Veterinary Manual
Pathology of Emphysema - Dr Sampurna Roy MD
UMCG Enrolls First Patients in PneumRx RENEW Pivotal Trial for Treatment of Severe Emphysema
Large Bronchogenic cyst Masquerading as Pericardial cyst and Causing Congenital lobar Emphysema | Journal of Cardiovascular...
CT findings of Budd-Chiari syndrome; low attenuation area and parenchymal enhancement of the liver<...
Serum Proteins Associated with Emphysema Progression in Severe Alpha-1 Antitrypsin Deficiency<...
UAB - School of Medicine - Medicine - UAB first in nation to test experimental therapy for emphysema
Congenital lobar overinflation | Radiology Reference Article | Radiopaedia.org
Semi-quantitative ventilation/perfusion scintigraphy and single-photon emission tomography for evaluation of lung volume...
NewYork-Presbyterian/Queens - Pulmonary Emphysema
Uptake Medical's BTVA has best safety profile per German Institute for Quality and Efficiency in Healthcare (IQWiG) - Uptake...
Pneumothorax and Pulmonary Interstitial Emphysema in the Newborn | Archives of Disease in Childhood
Emphysema (See Pulmonary Emphysema) - Aloe Products
European Respiratory Society statement - Forskning - Region Hovedstaden
Congenital cytomegalovirus infection associated with development of neonatal emphysematous lung disease -- Staunton et al.
...
Direct and Bone-Marrow Mediated Effects of Adipose Stem Cells in Emphysema
- Indiana University School of Medicine
Asthmatic Bronchitis And Early Emphysema - Asthmatic Bronchitis
Emphysema - Living With Emphysema | YourMedicalSource
COPD(Chronic Obstructive Pulmonary Disease/Emphysema and other Chronic Illnesses)
IJMS | Free Full-Text | Profiling the Proteome of Exhaled Breath Condensate in Healthy Smokers and COPD Patients by LC-MS/MS
Kuros and Aeris Sign Licensing Agreement - Redorbit
Emphysema - catch, body, causes, What Is Emphysema?
Causes of emphysema
Emphysema
Edgardo S. Salcedo, M.D. for UC Davis Health
Validity of apparent diffusion coefficient hyperpolarized He-3-MRI using MSCT and pulmonary function tests as references
How tobacco can Save You Time, Stress, and Money.
2014 ICD-9-CM Diagnosis Code 518.1 : Interstitial emphysema
Rapidly Progressive Pulmonary Apical Fibrosis and Parenchymal Destruction in a Patient with Ankylosing Spondylitis
CT Scan says (radiologist) Mild Emphysema Pulmonologist says NO
V/Q mismatch - emphysema
Pocket Reduction Surgery | The Dental Clinic
Emphysema | Central Arkansas Lung
Recommended post: How could Amy Winehouse have emphysema? - Terra Sigillata
Fabeha Fazal, Ph.D. - University of Rochester Medical Center
Inhibition of Elastase-Pulmonary Emphysema in Dominant-Negative MafB Transgenic Mice
In her own words: living with emphysema | Medical City Dallas
CPE | Encyclopedia.com
Centriacinar emphysema. Contact radiograph of an inflat | Open-i
The genetics of chronic obstructive pulmonary disease | Respiratory Research | Full Text
José Piñera Carvallo
Jakub Chlebowski
Enrico Martinelli
Twilight Alley
Ageratina adenophora
Aurelio Baldor
Progressive disease
Template:Respiratory pathology
Non-small-cell lung carcinoma
Exercise-induced bronchoconstriction
Pulmonary Emphysema Royalty Free Stock Image - Image: 22050446
Impact of exacerbations on emphysema progression in chronic obstructive pulmonary disease. - PubMed - NCBI
Pulmonary Emphysema. | Annals of Internal Medicine | American College of Physicians
Pulmonary emphysema | BMJ Evidence-Based Medicine
Pulmonary emphysema
Pulmonary emphysema, X-ray - Stock Image C021/2974 - Science Photo Library
Acute Bovine Pulmonary Emphysema and Edema - Respiratory System - Merck Veterinary Manual
Risk factors and clinical outcomes of pulmonary interstitial emphysema in extremely low birth weight infants.
Efficacy and Safety of Alpha1-Proteinase Inhibitor (Human), Modified Process (Alpha-1 MP) in Subjects With Pulmonary Emphysema...
Arterial stiffness is independently associated with emphysema severity in patients with chronic obstructive pulmonary disease
Quantitative analysis of pulmonary emphysema using isotropic Gaussian Markov random fields - ePrints Soton
Pulmonary Interstitial Emphysema: Pearls, Background, Pathophysiology
Imaging in Pulmonary Interstitial Emphysema: Practice Essentials, Radiography
Could I have Emphysema? - Chronic Obstructive Pulmonary Disease (COPD) - MedHelp
Retinoic acid treatment abrogates elastase-induced pulmonary emphysema in rats
Molecular Expressions Microscopy Primer: Specialized Microscopy Techniques - Phase Contrast Photomicrography Gallery -...
Pulmonary Emphysema - AHealthyMe - Blue Cross Blue Shield of Massachusetts
Acute bovine pulmonary emphysema-edema - definition of acute bovine pulmonary emphysema-edema by The Free Dictionary
What is the role of conventional ventilation (CMV) in the prevention of pulmonary interstitial emphysema (PIE)?
PULMONARY FIBROSIS AND EMPHYSEMA* | Annals of Internal Medicine | American College of Physicians
Small-airway obstruction and emphysema in chronic obstructive pulmonary disease. - PubMed - NCBI
Surgical resection for pulmonary interstitial emphysema in the newborn infant.
Emphysema and bronchiectasis in COPD patients with previous pulmonary | COPD
What is pulmonary interstitial emphysema (PIE) in babies? | Emphysema - Sharecare
Article - Sponge Lung: Pulmonary edema superimposed on emphysema
Influence of emphysema distribution on pulmonary function parameters in COPD patients
Gross Fixation Methods Used in the Study of Pulmonary Emphysema | Thorax
COPDCentrilobular emphysemaLobar emphysemaSevereFibrosisAlveolarDiagnosisComputed tomographyLungsDiseaseEmbolismTissueChestShortnessPathologyProgressionSeveritySymptomsNational Emphysema Treatment TrialRehabilitationFunctionUpper lobe emphysemaCombined Pulmonary Fibrosis and EmphysemaShortness of BreCause of emphysemaDiagnosis of emphysemaInterstitial Lung DiDiffuseCPFEObstructiveCentriacinar EmphysemaSymptoms of pulmonary emphysemaPathophysiologySign of emphysemaSubcutaneous emphysemaAirflowLobeOccursSacsIdiopathicDevelopment of pulmonaryMortalityCigaretteSmokersOnsetRadiographicPatients with advanced emphysemaPeople with pulmonaryPrevalencePattern of pulmonary
COPD11
- Emphysema often coexists with chronic bronchitis in the COPD population, and from a clinical point of view, they are generally considered as one entity. (medscape.com)
- Relationship of CT-quantified emphysema, small airways disease and bronchial wall dimensions with physiological, inflammatory and infective measures in COPD. (medscape.com)
- Images in COPD Combined Pulmonary Fibrosis and Emphysema. (medscape.com)
- More patients with chronic obstructive pulmonary disease (COPD) die of cardiovascular causes than of respiratory causes, and patients with COPD have increased morbidity and mortality from stroke and coronary heart disease. (nih.gov)
- Elastin fragmentation and changes in collagen are found in the connective tissue of both emphysematous lungs and stiff arteries, but it is not known whether the severity of arterial stiffness in patients with COPD is associated with the severity of emphysema. (nih.gov)
- Emphysema severity is associated with arterial stiffness in patients with COPD. (nih.gov)
- The NETT was the first multi-center trial to study whether lung volume reduction surgery (LVRS) was a safe and effective treatment for patients with chronic obstructive pulmonary disease (COPD) of the mainly emphysema type. (nih.gov)
- The NETT determined the benefits risks, and cost effectiveness of LVRS treatment of COPD with emphysema. (nih.gov)
- Chronic obstructive pulmonary disease (COPD) is a heterogeneous disease consisting of emphysema, small airway obstruction, and/or chronic bronchitis that results in significant loss of lung function over time. (biomedcentral.com)
- In order to gain insights into the molecular pathways underlying progression of emphysema and explore computational strategies for identifying COPD therapeutics, we profiled gene expression in lung tissue samples obtained from regions within the same lung with varying amounts of emphysematous destruction from smokers with COPD (8 regions × 8 lungs = 64 samples). (biomedcentral.com)
- We found concordant differential expression of these emphysema severity-associated genes in four cross-sectional studies of COPD. (biomedcentral.com)
Centrilobular emphysema1
- for example, 9 of 10 patients with RBILD (90%), described by Moon et al, (4) had centrilobular emphysema (see comments below on imaging). (thefreedictionary.com)
Lobar emphysema1
- For further information, see Imaging in Congenital Lobar Emphysema , Imaging in Emphysematous Pyelonephritis , and Imaging in Pulmonary Interstitial Emphysema . (medscape.com)
Severe11
- Functional and radiological findings have showed that these patients are suffering from severe breathlessness, but whose pulmonary functional tests revealed no signs of obstruction, normal static lung volumes, and depressed DLco, most with a history of smoking . (scirp.org)
- The RePneu LVRC, a minimally invasive medical implant designed to treat the symptoms of severe emphysema, is intended to improve lung function, exercise ability and quality of life for this underserved patient population. (mdtmag.com)
- There is no cure for severe emphysema, and patients have very few options available to relieve their symptoms," he said. (mdtmag.com)
- We have seen significant clinical improvements in treated patients, and we believe this is an important treatment option for many patients with severe emphysema. (mdtmag.com)
- The RENEW trial is enrolling patients throughout the US and Europe who have been clinically diagnosed with severe emphysema and are experiencing increasing difficulty with simple daily tasks despite optimal medical management. (mdtmag.com)
- Though RePneu LVRC is investigational in the United States and not yet approved for commercial use by the FDA, the device has been used in Europe - in clinical trials and commercially - for the treatment of severe emphysema since 2008. (mdtmag.com)
- This paper utilizes trial data to identify the predictors of HRQoL in patients with severe emphysema, and subsequently estimates the impact of a new treatment on HRQoL (measured by utilities). (uzh.ch)
- Conclusions: Coils and SoC resulted in statistically significant improvements in HRQoL compared to SoC alone in patients with severe emphysema. (uzh.ch)
- The 17 NETT clinical centers studied more than 1,200 patients who had severe emphysema. (nih.gov)
- The NETT clarified the short-term and long-term risks and benefits of LVRS as a treatment for severe emphysema. (nih.gov)
- A disorder marked by pulmonary inflation, primarily affecting the respiratory bronchioles and usually more severe in the upper lobes. (thefreedictionary.com)
Fibrosis4
- Definition of this syndrome was first named by Cottin as combined pulmonary fibrosis and emphysema (CPFE). (scirp.org)
- The radiological and endoscopic studies especially show that these patients have both areas of upper-lobe predominant emphysema and lesions compatible with fibrosis in both lung bases . (scirp.org)
- Pulmonary emphysema and idiopathic pulmonary fibrosis are once to be recognized as separate disease. (scirp.org)
- Viewed by angiography, SU5416-treated rat lungs showed a pruning of the pulmonary arterial tree, although we observed no lung infiltration by inflammatory cells or fibrosis. (jci.org)
Alveolar6
- Pulmonary emphysema is defined as the permanent enlargement of airspaces distal to the terminal bronchioles and the destruction of the alveolar walls. (medscape.com)
- To interpret these results, we established a novel simulation model and found that not only enlargement of preexisting low-attenuation areas but also coalescence of adjoining low-attenuation areas due to alveolar wall destruction caused emphysema progression in patients with exacerbations. (nih.gov)
- Pulmonary emphysema, a significant global health problem, is characterized by a loss of alveolar structures. (jci.org)
- Because VEGF is a trophic factor required for the survival of endothelial cells and is abundantly expressed in the lung, we hypothesized that chronic blockade of VEGF receptors could induce alveolar cell apoptosis and emphysema. (jci.org)
- These findings suggest that VEGF receptor signaling is required for maintenance of the alveolar structures and, further, that alveolar septal cell apoptosis contributes to the pathogenesis of emphysema. (jci.org)
- Regional emphysema severity was quantified in each tissue sample using the mean linear intercept (Lm) between alveolar walls from micro-CT scans. (biomedcentral.com)
Diagnosis3
- Although a tissue diagnosis of emphysema is possible, in advanced cases it can usually be confidently diagnosed on the basis of the patient's history, physical findings, pulmonary function, and imaging results. (medscape.com)
- High-resolution CT diagnosis of emphysema in symptomatic patients with normal chest radiographs and isolated low diffusing capacity. (medscape.com)
- A novel texture feature based on isotropic Gaussian Markov random fields is proposed for diagnosis and quantification of emphysema and its subtypes. (soton.ac.uk)
Computed tomography5
- Low-attenuation areas assessed by computed tomography reflect the extent of pathological emphysema and correlate with airflow limitation and mortality in patients with chronic obstructive pulmonary disease. (nih.gov)
- We investigated the relationship between exacerbation and emphysema progression assessed by computed tomography in patients with chronic obstructive pulmonary disease. (nih.gov)
- Annual changes in computed tomography parameters of emphysema were compared between patients with and without a history of exacerbations. (nih.gov)
- We assessed emphysema using quantitative computed tomography scanning in a subgroup of 73 patients. (nih.gov)
- Purpose: The purpose of this study is to evaluate multi-slice computed tomography technology to quantify functional and physiologic changes in rats with pulmonary emphysema. (elsevier.com)
Lungs1
Disease13
- Pulmonary emphysema and chronic bronchitis are important components of chronic obstructive pulmonary disease . (medscape.com)
- Advances in radiologic assessment of chronic obstructive pulmonary disease. (medscape.com)
- Impact of exacerbations on emphysema progression in chronic obstructive pulmonary disease. (nih.gov)
- Exacerbations of chronic obstructive pulmonary disease have a negative impact on lung function and prognosis. (nih.gov)
- This is the first longitudinal study to demonstrate that exacerbations are involved in emphysema progression in patients with chronic obstructive pulmonary disease. (nih.gov)
- Emphysema progression should be evaluated as part of the outcomes of exacerbations in the management of chronic obstructive pulmonary disease. (nih.gov)
- Lung densitometry to assess progression of emphysema in chronic obstructive pulmonary disease: time to apply in the clinic? (nih.gov)
- Emphysema is a disease that develops gradually, slowly making it harder and hard to breathe and get enough oxygen. (integrisok.com)
- Specific treatment for pulmonary emphysema will be determined by your doctor based on your age, overall health, medical history, the extent of the disease and your tolerance for specific medications, procedures, or therapies. (integrisok.com)
- Recent studies have described the combination of both pulmonary emphysema and idiopathic interstitial lung disease (ILDs) by means of high-resolution computed axial tomography (HRCT). (scirp.org)
- Unlike Lung Volume Reduction Surgery or other minimally invasive devices designed to treat emphysema, the RePneu LVRC is intended to treat a broad range of emphysema patients, including those with heterogeneous and homogeneous disease, in both upper and lower lobes, and it performs independently of collateral ventilation. (mdtmag.com)
- About Advanced Emphysema Over three million1 Europeans suffer from advanced emphysema, a chronic, debilitating disease most commonly brought on by years of smoking. (mdtmag.com)
- These results demonstrate that gene-expression changes associated with regional emphysema severity within an individual's lung can provide insights into emphysema pathogenesis and identify novel therapeutic opportunities for this deadly disease. (biomedcentral.com)
Embolism1
- 0.5 mg/L) and HRCT was conducted to rule out pulmonary embolism. (scirp.org)
Tissue1
- Emphysema causes irreversible damage to delicate lung tissue, leading to shortness of breath and even feelings of suffocation that result in reduced quality of life. (mdtmag.com)
Chest1
- Thurlbeck WM, Simon G. Radiographic appearance of the chest in emphysema. (medscape.com)
Shortness1
- There's little as frightening and frustrating as the feeling of not getting enough air, and this shortness of breath, can turn normal activities into major obstacles for people with emphysema. (integrisok.com)
Pathology2
- Reid L. The Pathology of Emphysema (Review: J Clin Pathol. (medscape.com)
- Reid L. The Pathology of Emphysema . (medscape.com)
Progression2
- CT Imaging-Based Low-Attenuation Super Clusters in Three Dimensions and the Progression of Emphysema. (medscape.com)
- However, the impact on emphysema progression remains unclear. (nih.gov)
Severity2
- To identify whether the extent of arterial stiffness is associated with emphysema severity. (nih.gov)
- We identified 127 genes whose expression levels were significantly associated with regional emphysema severity while controlling for gene expression differences between individuals. (biomedcentral.com)
Symptoms2
- The following are the most common symptoms for pulmonary emphysema. (integrisok.com)
- Infection can worsen emphysema symptoms, so both the pneumococcal and influenza vaccinations are recommended to prevent infection. (integrisok.com)
National Emphysema Treatment Trial2
Rehabilitation3
- Including breathing exercises to strengthen the muscles used in breathing as part of a pulmonary rehabilitation program, to condition the rest of the body. (integrisok.com)
- Our pulmonary rehabilitation programs at INTEGRIS help you by creating individualized plans and education, so you can do more things you enjoy. (integrisok.com)
- Patients must be over 35 years of age, must have stopped smoking for at least eight weeks and must have completed a pulmonary rehabilitation program within six months and/or be on a maintenance program. (mdtmag.com)
Function1
- Emphysema is medically characterized by reduced lung function and increased lung volume, which makes breathing very difficult. (mdtmag.com)
Upper lobe emphysema1
- This outcome would be especially likely for patients found to gain the most from LVRS-those with upper-lobe emphysema and low exercise capacity. (nih.gov)
Combined Pulmonary Fibrosis and Emphysema10
- Combined pulmonary fibrosis and emphysema describes a medical syndrome involving both pulmonary fibrosis and emphysema. (wikipedia.org)
- This study aims to describe the haemodynamic and survival characteristics of patients with pulmonary hypertension in the recently individualised syndrome of combined pulmonary fibrosis and emphysema. (ersjournals.com)
- 39 smokers) with combined pulmonary fibrosis and emphysema, and pulmonary hypertension at right heart catheterisation. (ersjournals.com)
- Patients with combined pulmonary fibrosis and emphysema syndrome and pulmonary hypertension confirmed by right heart catheterisation have a dismal prognosis despite moderately altered lung volumes and flows and moderately severe haemodynamic parameters. (ersjournals.com)
- We recently individualised the syndrome of combined pulmonary fibrosis and emphysema (CPFE) 4 based on high-resolution computed tomography (HRCT) of the chest in a homogeneous group of 61 patients, further characterised by severe dyspnoea on exertion, subnormal spirometry, severe impairment of gas exchange and a median survival of 6.1 yrs 5 . (ersjournals.com)
- We explored whether an autoimmune process implicating anti-elastin autoantibodies and facilitated by tobacco smoking may take place in patients with combined pulmonary fibrosis and emphysema (CPFE), a distinct entity recently defined on the basis of characteristic features of chest imaging, pulmonary function and outcome 4 . (ersjournals.com)
- Quantification of anti-elastin antibodies using ELISA in patients with combined pulmonary fibrosis and emphysema (CPFE) and controls. (ersjournals.com)
- The syndrome of combined pulmonary fibrosis and emphysema (CPFE) is characterised by upper lobe emphysema and lower lobe fibrosis. (ersjournals.com)
- Indeed, several groups have described series of combined pulmonary fibrosis and emphysema (CPFE) [ 1 - 4 ], with upper lobe emphysema and pulmonary fibrosis of the lower lungs [ 5 ]. (ersjournals.com)
- Groupe d'Etude et de Recherche sur les Maladies Orphelines Pulmonaires (GERM O P). Combined pulmonary fibrosis and emphysema: a distinct underrecognised entity. (viamedica.pl)
Shortness of Bre11
- There's little as frightening and frustrating as the feeling of not getting enough air, and this shortness of breath, can turn normal activities into major obstacles for people with emphysema. (integrisok.com)
- A 54-year-old male with known history of emphysema, coronary artery disease, and congestive heart failure presented with chest pain and shortness of breath of three days' duration. (appliedradiology.com)
- The main sign of emphysema is shortness of breath. (webmd.com)
- Shortness of breath and cough are the main symptoms of emphysema. (medicalnewstoday.com)
- Two of the key symptoms of emphysema are shortness of breath and a chronic cough. (medicalnewstoday.com)
- A chronic cough is one of the early signs of emphysema, alongside shortness of breath. (medicalnewstoday.com)
- You and your doctor may be concerned if you have any signs or symptoms of emphysema such as shortness of breath, a chronic cough (with or without sputum production,) reduced exercise tolerance or unintended weight loss. (verywellhealth.com)
- This leads to the shortness of breath that characterizes emphysema. (healthcentral.com)
- Emphysema is a lung condition that causes shortness of breath. (mayoclinic.org)
- The main symptom of emphysema is shortness of breath, which usually begins gradually. (mayoclinic.org)
- Emphysema eventually causes shortness of breath even while you're at rest. (mayoclinic.org)
Cause of emphysema1
- The main cause of emphysema is cigarette smoking. (sciencephoto.com)
Diagnosis of emphysema6
- Although a tissue diagnosis of emphysema is possible, in advanced cases it can usually be confidently diagnosed on the basis of the patient's history, physical findings, pulmonary function, and imaging results. (medscape.com)
- High-resolution CT diagnosis of emphysema in symptomatic patients with normal chest radiographs and isolated low diffusing capacity. (medscape.com)
- In the United States (U.S.), 3.5 million people, or 1.5 percent of the population, received a diagnosis of emphysema in 2016. (medicalnewstoday.com)
- Studies like the Lung Health Study have shown that stopping smoking at any time even after diagnosis of emphysema may help reduce the risk of progression of lung damage. (news-medical.net)
- Your doctor will perform an initial chest x-ray to help her reach a diagnosis of emphysema, and then intermittently throughout your treatment to monitor your progress. (verywellhealth.com)
- If these suggest a diagnosis of emphysema, diagnostic tests may be performed. (healthcentral.com)
Interstitial Lung Di4
- Prevalence and Effects of Emphysema in Never-Smokers with Rheumatoid Arthritis Interstitial Lung Disease. (annals.org)
- Immune mechanisms are also implicated in interstitial lung disease and pulmonary fibrosis 2 , and smoking-induced autoimmunity has been demonstrated in rheumatoid arthritis 3 . (ersjournals.com)
- Patients with emphysema (N = 16), interstitial lung disease (ILD) (N = 15), obesity (N = 15) and healthy controls (N = 16) were included. (biomedcentral.com)
- Thoracic gas compression was investigated in four groups of subjects with different pulmonary mechanics: healthy non-smoking subjects (controls), healthy non-smoking obese subjects (obese), patients with interstitial lung disease (ILD) and patients with emphysema (emphysema). (biomedcentral.com)
Diffuse2
- When a superimposed diffuse interstitial and alveolar process then occurs, it accentuates these lucencies within the secondary pulmonary lobule amongst surrounding opacity creating the appearance of a sponge on radiographs and CT. (appliedradiology.com)
- There is diffuse destruction of lung tissue throughout the lobule as opposed to centrolobular emphysema in which the lung destruction is bronchocentric in the center of the lobule. (humpath.com)
CPFE7
- CPFE is probably related to tobacco smoking, a common risk factor for both emphysema and fibrosis (with odds ratios of up to 3.6 in familial fibrosis) 6 , 7 . (ersjournals.com)
- Our results do not support the idea that either emphysema or fibrosis in CPFE may be mediated by an autoimmune process directed against elastin. (ersjournals.com)
- Since all patients with CPFE had emphysema on imaging (mostly paraseptal emphysema, and also centrolobular emphysema), our results also fail to confirm the presence of circulating anti-elastin antibodies in patients with emphysema (at least when associated with fibrosis). (ersjournals.com)
- In addition, CPFE has major effects on measures of physiological function, exercise capacity and prognosis, and may affect the results of pulmonary fibrosis trials. (ersjournals.com)
- The risk of the development of PH is elevated (about 50%) and is higher in patients with CPFE than either IPF or emphysema alone, and its onset heralds a poor prognosis and increased mortality [ 4 , 18 ]. (ersjournals.com)
- In one cohort of 110 patients, 31 (28%) patients with CPFE had a higher mortality than IPF patients without emphysema (median survival time of 25 versus 34 months, p=0.01) [ 16 ]. (ersjournals.com)
- In most cases, CPFE occurs as the development of fibrosis superimposed on a known history of emphysema that may modify its progression. (ersjournals.com)
Obstructive13
- Pulmonary emphysema and chronic bronchitis are important components of chronic obstructive pulmonary disease . (medscape.com)
- Advances in radiologic assessment of chronic obstructive pulmonary disease. (medscape.com)
- Impact of exacerbations on emphysema progression in chronic obstructive pulmonary disease. (nih.gov)
- Exacerbations of chronic obstructive pulmonary disease have a negative impact on lung function and prognosis. (nih.gov)
- This is the first longitudinal study to demonstrate that exacerbations are involved in emphysema progression in patients with chronic obstructive pulmonary disease. (nih.gov)
- Emphysema progression should be evaluated as part of the outcomes of exacerbations in the management of chronic obstructive pulmonary disease. (nih.gov)
- Lung densitometry to assess progression of emphysema in chronic obstructive pulmonary disease: time to apply in the clinic? (nih.gov)
- Autoantibodies in Chronic Obstructive Pulmonary Disease. (annals.org)
- Small-airway obstruction and emphysema in chronic obstructive pulmonary disease. (nih.gov)
- Diagnostic Confirmation: Are you sure your patient has chronic obstructive pulmonary disease? (renalandurologynews.com)
- Sin D, Hollander Z, DeMarco M, McManus B, Ng R (2015) Biomarker development for chronic obstructive pulmonary disease. (springer.com)
- Retrospective study of pulmonary function tests in patients presenting with isolated reduction in single-breath diffusion capacity: implications for the diagnosis of combined obstructive and restrictive lung disease. (viamedica.pl)
- Emphysema is a type of chronic obstructive pulmonary disease. (medicalnewstoday.com)
Centriacinar Emphysema1
Symptoms of pulmonary emphysema2
- What are the symptoms of pulmonary emphysema? (ahealthyme.com)
- The symptoms of pulmonary emphysema may look like other lung conditions or health problems. (ahealthyme.com)
Pathophysiology1
- AMs play important roles in the pathogenesis and pathophysiology of pulmonary emphysema [ 5 , 6 ]. (ijbs.com)
Sign of emphysema1
- With you not having smoked for 20 years, it is quite unlikely that your current dry cough is a sign of emphysema. (medhelp.org)
Subcutaneous emphysema8
- Some cattle have subcutaneous emphysema extending along the back from the withers. (merckvetmanual.com)
- Eight of those attended had severe respiratory distress and subcutaneous emphysema. (up.ac.za)
- Selenium deficiency was detected only in those animals which showed respiratory embarrassment and subcutaneous emphysema. (up.ac.za)
- Subcutaneous emphysema, pneumomediastinum, and potentially life-threatening tension pneumothorax. (semanticscholar.org)
- Subcutaneous emphysema, pneumomediastinum, and tension pneumothorax are previously unreported complications of shoulder arthroscopy with subacromial decompression. (semanticscholar.org)
- Three patients developed extensive subcutaneous emphysema, pneumomediastinum, and bilateral tension pneumothorax during or immediately after shoulder arthroscopy with subacromial decompression. (semanticscholar.org)
- Extensive subcutaneous emphysema resembling necrotizing fasciitis. (semanticscholar.org)
- Pneumothorax and subcutaneous emphysema complicating endotracheal intubation. (semanticscholar.org)
Airflow3
- 1 Chronic airflow limitation may be caused by increased resistance of the small conducting airways and increased compliance of the lung due to emphysema. (bmj.com)
- Twenty six (21%) emphysema subjects had no evidence of airflow obstruction (FEV1/FVC ratio 23% emphysema showed airflow obstruction. (mdpi.com)
- Airway wall thickness quantified by CT morphometry was associated with airflow limitation, but not with emphysema indicating that the heterogeneous nature of lung disease in smokers may represent distinct phenotypes. (mdpi.com)
Lobe2
- It usually involves the upper lobe and is the most common type of emphysema. (humpath.com)
- The newly published findings from the largest study of bilateral lung volume reduction surgery (LVRS) to treat severe emphysema also confirm that patients with upper-lobe emphysema and poor exercise capacity before surgery are more likely to have improved survival compared to similar patients treated with medical therapy without surgery. (psychcentral.com)
Occurs3
- Pulmonary emphysema occurs very slowly over time. (ahealthyme.com)
- Emphysema does not develop suddenly, but occurs very gradually. (nyhq.org)
- Although the lung damage that occurs in emphysema develops gradually, most people with tobacco-related emphysema begin to experience symptoms of the disease between the ages of 40 and 60. (mayoclinic.org)
Sacs2
- Emphysema is a progressive, destructive lung disease in which the walls between the tiny air sacs are damaged. (columbiasurgery.org)
- The main problem in emphysema is that the walls of the air sacs are destroyed. (medicalnewstoday.com)
Idiopathic3
- Idiopathic pulmonary fibrosis (IPF) is a severe chronic disease of unknown aetiology, with a median survival of 3 yrs. (ersjournals.com)
- Several groups have described a syndrome in which idiopathic pulmonary fibrosis (IPF) coexists with pulmonary emphysema. (ersjournals.com)
- Idiopathic pulmonary fibrosis. (viamedica.pl)
Development of pulmonary1
- The aim of this study was to elucidate the roles of MafB in the development of pulmonary emphysema. (ijbs.com)
Mortality2
- CONCLUSION: Pulmonary interstitial emphysema is associated with increased mortality in ELBW infants. (biomedsearch.com)
- Because, it has been reported that endobronchial lung volume reduction may have a beneficial effect without increased mortality in patients with emphysema and PH, we evaluated its effect on PH in patients undergoing LVRS. (uzh.ch)
Cigarette8
- The Biochemical Basis of Emphysema: the Oxidant Effect of Cigarette Smoke? (annals.org)
- We postulated that Rtp801 acts as potential amplifying switch in the development of cigarette smoke - induced lung injury, leading to emphysema. (pubmedcentralcanada.ca)
- On the other hand, Rtp801 − / − mice were markedly protected against acute cigarette smoke - induced lung injury, partly via increased mTOR signaling, and, when exposed chronically, against emphysema. (pubmedcentralcanada.ca)
- Cigarette smoke is the biggest cause of both emphysema and chronic bronchitis. (webmd.com)
- Most cases of emphysema are due to cigarette smoking. (medicalnewstoday.com)
- Smoking (as well as passive exposure to cigarette smoke) remains one of the best known and most closely associated causes of emphysema. (news-medical.net)
- Up to 85 percent of emphysema cases develop in longtime cigarette smokers. (healthcentral.com)
- Emphysema is most likely to develop in cigarette smokers, but cigar and pipe smokers also are susceptible. (mayoclinic.org)
Smokers3
- In smokers, some emphysema may be associated with IPF 1 - 3 . (ersjournals.com)
- Emphysema is largely an under-diagnosed medical condition that can exist in smokers in the absence of airway obstruction. (mdpi.com)
- In this cohort of lifetime ever-smokers, PFTs alone were inadequate for diagnosing emphysema. (mdpi.com)
Onset1
- Acute bovine pulmonary emphysema and edema (ABPEE) is one of the more common causes of acute respiratory distress in cattle, particularly adult beef cattle, and is characterized by sudden onset, minimal coughing, and a course that ends fatally or improves dramatically within a few days. (merckvetmanual.com)
Radiographic3
- This radiograph, obtained from a premature infant at 26 weeks' gestation, shows characteristic radiographic changes of pulmonary interstitial emphysema (PIE) of the right lung. (medscape.com)
- PFTs were used individually and in combination to predict their ability to discriminate radiographic emphysema. (mdpi.com)
- The sensitivity and specificity of spirometry for detecting radiographic emphysema were 79% and 75%, respectively. (mdpi.com)
Patients with advanced emphysema1
- Weight loss, which is common in patients with advanced emphysema, can be caused by inadequate food intake in individuals too short of breath to eat. (columbiasurgery.org)
People with pulmonary1
- The goal of treatment for people with pulmonary emphysema is to live more comfortably with the disease, control symptoms, and prevent the disease from getting worse, with minimal side effects. (ahealthyme.com)
Prevalence2
- The prevalence of pulmonary interstitial emphysema widely varies with the population studied. (wikipedia.org)
- The term 'prevalence' of Berry aneurysm, cirrhosis, pulmonary emphysema, and cerebral calcification usually refers to the estimated population of people who are managing Berry aneurysm, cirrhosis, pulmonary emphysema, and cerebral calcification at any given time. (rightdiagnosis.com)
Pattern of pulmonary2
- Close-up examination shows the typical linear pattern of pulmonary interstitial emphysema. (medscape.com)
- In our experience, however, a new radiologic pattern of pulmonary edema superimposed on emphysema is often seen, one that we term Sponge Lung due to its characteristic appearance, not previously described in the radiologic literature. (appliedradiology.com)