The circulation of the BLOOD through the LUNGS.
The short wide vessel arising from the conus arteriosus of the right ventricle and conveying unaerated blood to the lungs.
Increased VASCULAR RESISTANCE in the PULMONARY CIRCULATION, usually secondary to HEART DISEASES or LUNG DISEASES.
The movement of the BLOOD as it is pumped through the CARDIOVASCULAR SYSTEM.
Either of the pair of organs occupying the cavity of the thorax that effect the aeration of the blood.
Relatively complete absence of oxygen in one or more tissues.
The force that opposes the flow of BLOOD through a vascular bed. It is equal to the difference in BLOOD PRESSURE across the vascular bed divided by the CARDIAC OUTPUT.
A fetal blood vessel connecting the pulmonary artery with the descending aorta.
Hypertrophy and dilation of the RIGHT VENTRICLE of the heart that is caused by PULMONARY HYPERTENSION. This condition is often associated with pulmonary parenchymal or vascular diseases, such as CHRONIC OBSTRUCTIVE PULMONARY DISEASE and PULMONARY EMBOLISM.
The movement and the forces involved in the movement of the blood through the CARDIOVASCULAR SYSTEM.
The physiological narrowing of BLOOD VESSELS by contraction of the VASCULAR SMOOTH MUSCLE.
The veins that return the oxygenated blood from the lungs to the left atrium of the heart.
Enlargement of the RIGHT VENTRICLE of the heart. This increase in ventricular mass is often attributed to PULMONARY HYPERTENSION and is a contributor to cardiovascular morbidity and mortality.
The pressure within the CARDIAC ATRIUM. It can be measured directly by using a pressure catheter (see HEART CATHETERIZATION). It can be also estimated using various imaging techniques or other pressure readings such as PULMONARY CAPILLARY WEDGE PRESSURE (an estimate of left atrial pressure) and CENTRAL VENOUS PRESSURE (an estimate of right atrial pressure).
PRESSURE of the BLOOD on the ARTERIES and other BLOOD VESSELS.
A free radical gas produced endogenously by a variety of mammalian cells, synthesized from ARGININE by NITRIC OXIDE SYNTHASE. Nitric oxide is one of the ENDOTHELIUM-DEPENDENT RELAXING FACTORS released by the vascular endothelium and mediates VASODILATION. It also inhibits platelet aggregation, induces disaggregation of aggregated platelets, and inhibits platelet adhesion to the vascular endothelium. Nitric oxide activates cytosolic GUANYLATE CYCLASE and thus elevates intracellular levels of CYCLIC GMP.
The vascular resistance to the flow of BLOOD through the CAPILLARIES portions of the peripheral vascular bed.
The volume of BLOOD passing through the HEART per unit of time. It is usually expressed as liters (volume) per minute so as not to be confused with STROKE VOLUME (volume per beat).
Any of the ruminant mammals with curved horns in the genus Ovis, family Bovidae. They possess lachrymal grooves and interdigital glands, which are absent in GOATS.
The hemodynamic and electrophysiological action of the right HEART VENTRICLE.
A syndrome of persistent PULMONARY HYPERTENSION in the newborn infant (INFANT, NEWBORN) without demonstrable HEART DISEASES. This neonatal condition can be caused by severe pulmonary vasoconstriction (reactive type), hypertrophy of pulmonary arterial muscle (hypertrophic type), or abnormally developed pulmonary arterioles (hypoplastic type). The newborn patient exhibits CYANOSIS and ACIDOSIS due to the persistence of fetal circulatory pattern of right-to-left shunting of blood through a patent ductus arteriosus (DUCTUS ARTERIOSUS, PATENT) and at times a patent foramen ovale (FORAMEN OVALE, PATENT).
The anatomical study of specific regions or parts of organisms, emphasizing the relationship between the various structures (e.g. muscles, nerves, skeletal, cardiovascular, etc.).
The exchange of OXYGEN and CARBON DIOXIDE between alveolar air and pulmonary capillary blood that occurs across the BLOOD-AIR BARRIER.
The physiological widening of BLOOD VESSELS by relaxing the underlying VASCULAR SMOOTH MUSCLE.
The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065)
Treatment process involving the injection of fluid into an organ or tissue.
The blood pressure as recorded after wedging a CATHETER in a small PULMONARY ARTERY; believed to reflect the PRESSURE in the pulmonary CAPILLARIES.
Drugs used to cause dilation of the blood vessels.
Diversion of blood flow through a circuit located outside the body but continuous with the bodily circulation.
Theoretical representations that simulate the behavior or activity of the cardiovascular system, processes, or phenomena; includes the use of mathematical equations, computers and other electronic equipment.
Left bronchial arteries arise from the thoracic aorta, the right from the first aortic intercostal or the upper left bronchial artery; they supply the bronchi and the lower trachea.
Excessive accumulation of extravascular fluid in the lung, an indication of a serious underlying disease or disorder. Pulmonary edema prevents efficient PULMONARY GAS EXCHANGE in the PULMONARY ALVEOLI, and can be life-threatening.
A value equal to the total volume flow divided by the cross-sectional area of the vascular bed.
Procedures in which placement of CARDIAC CATHETERS is performed for therapeutic or diagnostic procedures.
A stable prostaglandin endoperoxide analog which serves as a thromboxane mimetic. Its actions include mimicking the hydro-osmotic effect of VASOPRESSIN and activation of TYPE C PHOSPHOLIPASES. (From J Pharmacol Exp Ther 1983;224(1): 108-117; Biochem J 1984;222(1):103-110)
The biological science concerned with the life-supporting properties, functions, and processes of living organisms or their parts.
Symmetrical osteitis of the four limbs, chiefly localized to the phalanges and the terminal epiphyses of the long bones of the forearm and leg, sometimes extending to the proximal ends of the limbs and the flat bones, and accompanied by dorsal kyphosis and joint involvement. It is often secondary to chronic conditions of the lungs and heart. (Dorland, 27th ed)
The unborn young of a viviparous mammal, in the postembryonic period, after the major structures have been outlined. In humans, the unborn young from the end of the eighth week after CONCEPTION until BIRTH, as distinguished from the earlier EMBRYO, MAMMALIAN.
A condition in which the RIGHT VENTRICLE of the heart was functionally impaired. This condition usually leads to HEART FAILURE or MYOCARDIAL INFARCTION, and other cardiovascular complications. Diagnosis is made by measuring the diminished ejection fraction and a depressed level of motility of the right ventricular wall.
The flow of BLOOD through or around an organ or region of the body.
The administration of drugs by the respiratory route. It includes insufflation into the respiratory tract.
The blood pressure in the VEINS. It is usually measured to assess the filling PRESSURE to the HEART VENTRICLE.
Devices for accelerating protons or electrons in closed orbits where the accelerating voltage and magnetic field strength varies (the accelerating voltage is held constant for electrons) in order to keep the orbit radius constant.
A 21-amino acid peptide produced in a variety of tissues including endothelial and vascular smooth-muscle cells, neurons and astrocytes in the central nervous system, and endometrial cells. It acts as a modulator of vasomotor tone, cell proliferation, and hormone production. (N Eng J Med 1995;333(6):356-63)
A type of impedance plethysmography in which bioelectrical impedance is measured between electrodes positioned around the neck and around the lower thorax. It is used principally to calculate stroke volume and cardiac volume, but it is also related to myocardial contractility, thoracic fluid content, and circulation to the extremities.
An element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on earth and essential for respiration.
The act of breathing with the LUNGS, consisting of INHALATION, or the taking into the lungs of the ambient air, and of EXHALATION, or the expelling of the modified air which contains more CARBON DIOXIDE than the air taken in (Blakiston's Gould Medical Dictionary, 4th ed.). This does not include tissue respiration (= OXYGEN CONSUMPTION) or cell respiration (= CELL RESPIRATION).
Rhythmic, intermittent propagation of a fluid through a BLOOD VESSEL or piping system, in contrast to constant, smooth propagation, which produces laminar flow.
A pyrrolizidine alkaloid and a toxic plant constituent that poisons livestock and humans through the ingestion of contaminated grains and other foods. The alkaloid causes pulmonary artery hypertension, right ventricular hypertrophy, and pathological changes in the pulmonary vasculature. Significant attenuation of the cardiopulmonary changes are noted after oral magnesium treatment.
The pathologic narrowing of the orifice of the PULMONARY VALVE. This lesion restricts blood outflow from the RIGHT VENTRICLE to the PULMONARY ARTERY. When the trileaflet valve is fused into an imperforate membrane, the blockage is complete.
The minute vessels that connect the arterioles and venules.
Drugs used to cause constriction of the blood vessels.
Small polyhedral outpouchings along the walls of the alveolar sacs, alveolar ducts and terminal bronchioles through the walls of which gas exchange between alveolar air and pulmonary capillary blood takes place.
Blocking of the PULMONARY ARTERY or one of its branches by an EMBOLUS.
Refers to animals in the period of time just after birth.
Single pavement layer of cells which line the luminal surface of the entire vascular system and regulate the transport of macromolecules and blood components.
A congenital heart defect characterized by the persistent opening of fetal DUCTUS ARTERIOSUS that connects the PULMONARY ARTERY to the descending aorta (AORTA, DESCENDING) allowing unoxygenated blood to bypass the lung and flow to the PLACENTA. Normally, the ductus is closed shortly after birth.
Synthetic compounds that are analogs of the naturally occurring prostaglandin endoperoxides and that mimic their pharmacologic and physiologic activities. They are usually more stable than the naturally occurring compounds.
A 52-amino acid peptide with multi-functions. It was originally isolated from PHEOCHROMOCYTOMA and ADRENAL MEDULLA but is widely distributed throughout the body including lung and kidney tissues. Besides controlling fluid-electrolyte homeostasis, adrenomedullin is a potent vasodilator and can inhibit pituitary ACTH secretion.
Developmental abnormalities involving structures of the heart. These defects are present at birth but may be discovered later in life.
An NADPH-dependent enzyme that catalyzes the conversion of L-ARGININE and OXYGEN to produce CITRULLINE and NITRIC OXIDE.
An inhibitor of nitric oxide synthetase which has been shown to prevent glutamate toxicity. Nitroarginine has been experimentally tested for its ability to prevent ammonia toxicity and ammonia-induced alterations in brain energy and ammonia metabolites. (Neurochem Res 1995:200(4):451-6)
Maintenance of blood flow to an organ despite obstruction of a principal vessel. Blood flow is maintained through small vessels.
21-Amino-acid peptides produced by vascular endothelial cells and functioning as potent vasoconstrictors. The endothelin family consists of three members, ENDOTHELIN-1; ENDOTHELIN-2; and ENDOTHELIN-3. All three peptides contain 21 amino acids, but vary in amino acid composition. The three peptides produce vasoconstrictor and pressor responses in various parts of the body. However, the quantitative profiles of the pharmacological activities are considerably different among the three isopeptides.
Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care. (Dictionary of Health Services Management, 2d ed)
A CALCIUM-dependent, constitutively-expressed form of nitric oxide synthase found primarily in ENDOTHELIAL CELLS.
A prostaglandin that is a powerful vasodilator and inhibits platelet aggregation. It is biosynthesized enzymatically from PROSTAGLANDIN ENDOPEROXIDES in human vascular tissue. The sodium salt has been also used to treat primary pulmonary hypertension (HYPERTENSION, PULMONARY).
The nonstriated involuntary muscle tissue of blood vessels.
The lower right and left chambers of the heart. The right ventricle pumps venous BLOOD into the LUNGS and the left ventricle pumps oxygenated blood into the systemic arterial circulation.
Elements of limited time intervals, contributing to particular results or situations.
Any of the tubular vessels conveying the blood (arteries, arterioles, capillaries, venules, and veins).
An abnormal direct communication between an artery and a vein without passing through the CAPILLARIES. An A-V fistula usually leads to the formation of a dilated sac-like connection, arteriovenous aneurysm. The locations and size of the shunts determine the degree of effects on the cardiovascular functions such as BLOOD PRESSURE and HEART RATE.
The circulation of the BLOOD through the MICROVASCULAR NETWORK.
Radiography of blood vessels after injection of a contrast medium.
A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.
Pathological processes involving any part of the LUNG.
Measurement of oxygen and carbon dioxide in the blood.
An infant during the first month after birth.
Volume of circulating BLOOD. It is the sum of the PLASMA VOLUME and ERYTHROCYTE VOLUME.
Cell surface proteins that bind ENDOTHELINS with high affinity and trigger intracellular changes which influence the behavior of cells.
Guanosine cyclic 3',5'-(hydrogen phosphate). A guanine nucleotide containing one phosphate group which is esterified to the sugar moiety in both the 3'- and 5'-positions. It is a cellular regulatory agent and has been described as a second messenger. Its levels increase in response to a variety of hormones, including acetylcholine, insulin, and oxytocin and it has been found to activate specific protein kinases. (From Merck Index, 11th ed)
Recycling through liver by excretion in bile, reabsorption from intestines (INTESTINAL REABSORPTION) into portal circulation, passage back into liver, and re-excretion in bile.
The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.
Any of various animals that constitute the family Suidae and comprise stout-bodied, short-legged omnivorous mammals with thick skin, usually covered with coarse bristles, a rather long mobile snout, and small tail. Included are the genera Babyrousa, Phacochoerus (wart hogs), and Sus, the latter containing the domestic pig (see SUS SCROFA).
The hollow, muscular organ that maintains the circulation of the blood.
A powerful vasodilator used in emergencies to lower blood pressure or to improve cardiac function. It is also an indicator for free sulfhydryl groups in proteins.
A type of stress exerted uniformly in all directions. Its measure is the force exerted per unit area. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)
The number of times the HEART VENTRICLES contract per unit of time, usually per minute.
The volume of packed RED BLOOD CELLS in a blood specimen. The volume is measured by centrifugation in a tube with graduated markings, or with automated blood cell counters. It is an indicator of erythrocyte status in disease. For example, ANEMIA shows a low value; POLYCYTHEMIA, a high value.
The circulation of blood through the CORONARY VESSELS of the HEART.
The circulation of blood through the BLOOD VESSELS of the BRAIN.
A potent natriuretic and vasodilatory peptide or mixture of different-sized low molecular weight PEPTIDES derived from a common precursor and secreted mainly by the HEART ATRIUM. All these peptides share a sequence of about 20 AMINO ACIDS.
The species Oryctolagus cuniculus, in the family Leporidae, order LAGOMORPHA. Rabbits are born in burrows, furless, and with eyes and ears closed. In contrast with HARES, rabbits have 22 chromosome pairs.
Measurement of intracardiac blood flow using an M-mode and/or two-dimensional (2-D) echocardiogram while simultaneously recording the spectrum of the audible Doppler signal (e.g., velocity, direction, amplitude, intensity, timing) reflected from the moving column of red blood cells.
A group of compounds derived from unsaturated 20-carbon fatty acids, primarily arachidonic acid, via the cyclooxygenase pathway. They are extremely potent mediators of a diverse group of physiological processes.
Organic compounds containing the -CO-NH2 radical. Amides are derived from acids by replacement of -OH by -NH2 or from ammonia by the replacement of H by an acyl group. (From Grant & Hackh's Chemical Dictionary, 5th ed)
Highly specialized EPITHELIAL CELLS that line the HEART; BLOOD VESSELS; and lymph vessels, forming the ENDOTHELIUM. They are polygonal in shape and joined together by TIGHT JUNCTIONS. The tight junctions allow for variable permeability to specific macromolecules that are transported across the endothelial layer.
A non-selective inhibitor of nitric oxide synthase. It has been used experimentally to induce hypertension.
The relationship between the dose of an administered drug and the response of the organism to the drug.
The circulation of BLOOD, of both the mother and the FETUS, through the PLACENTA.
The property of blood capillary ENDOTHELIUM that allows for the selective exchange of substances between the blood and surrounding tissues and through membranous barriers such as the BLOOD-AIR BARRIER; BLOOD-AQUEOUS BARRIER; BLOOD-BRAIN BARRIER; BLOOD-NERVE BARRIER; BLOOD-RETINAL BARRIER; and BLOOD-TESTIS BARRIER. Small lipid-soluble molecules such as carbon dioxide and oxygen move freely by diffusion. Water and water-soluble molecules cannot pass through the endothelial walls and are dependent on microscopic pores. These pores show narrow areas (TIGHT JUNCTIONS) which may limit large molecule movement.
Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.
An essential amino acid that is physiologically active in the L-form.
The circulation of blood through the BLOOD VESSELS supplying the abdominal VISCERA.
The main trunk of the systemic arteries.
A group of intracellular-signaling serine threonine kinases that bind to RHO GTP-BINDING PROTEINS. They were originally found to mediate the effects of rhoA GTP-BINDING PROTEIN on the formation of STRESS FIBERS and FOCAL ADHESIONS. Rho-associated kinases have specificity for a variety of substrates including MYOSIN-LIGHT-CHAIN PHOSPHATASE and LIM KINASES.
A colorless, odorless gas that can be formed by the body and is necessary for the respiration cycle of plants and animals.
A strain of albino rat developed at the Wistar Institute that has spread widely at other institutions. This has markedly diluted the original strain.
The larger air passages of the lungs arising from the terminal bifurcation of the TRACHEA. They include the largest two primary bronchi which branch out into secondary bronchi, and tertiary bronchi which extend into BRONCHIOLES and PULMONARY ALVEOLI.
The age of the conceptus, beginning from the time of FERTILIZATION. In clinical obstetrics, the gestational age is often estimated as the time from the last day of the last MENSTRUATION which is about 2 weeks before OVULATION and fertilization.
Determination of the shortest time interval between the injection of a substance in the vein and its arrival at some distant site in sufficient concentration to produce a recognizable end result. It represents approximately the inverse of the average velocity of blood flow between two points.
A neurotransmitter found at neuromuscular junctions, autonomic ganglia, parasympathetic effector junctions, a subset of sympathetic effector junctions, and at many sites in the central nervous system.
The range or frequency distribution of a measurement in a population (of organisms, organs or things) that has not been selected for the presence of disease or abnormality.
Non-striated, elongated, spindle-shaped cells found lining the digestive tract, uterus, and blood vessels. They are derived from specialized myoblasts (MYOBLASTS, SMOOTH MUSCLE).
Substances used to allow enhanced visualization of tissues.
The circulation of BLOOD through the LIVER.
Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations or by parent x offspring matings carried out with certain restrictions. This also includes animals with a long history of closed colony breeding.
Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction.
The rate at which oxygen is used by a tissue; microliters of oxygen STPD used per milligram of tissue per hour; the rate at which oxygen enters the blood from alveolar gas, equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body. (Stedman, 25th ed, p346)
Theoretical representations that simulate the behavior or activity of biological processes or diseases. For disease models in living animals, DISEASE MODELS, ANIMAL is available. Biological models include the use of mathematical equations, computers, and other electronic equipment.
A biochemical messenger and regulator, synthesized from the essential amino acid L-TRYPTOPHAN. In humans it is found primarily in the central nervous system, gastrointestinal tract, and blood platelets. Serotonin mediates several important physiological functions including neurotransmission, gastrointestinal motility, hemostasis, and cardiovascular integrity. Multiple receptor families (RECEPTORS, SEROTONIN) explain the broad physiological actions and distribution of this biochemical mediator.
A heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic need of the body. Heart failure can be caused by structural defects, functional abnormalities (VENTRICULAR DYSFUNCTION), or a sudden overload beyond its capacity. Chronic heart failure is more common than acute heart failure which results from sudden insult to cardiac function, such as MYOCARDIAL INFARCTION.
Ultrasonic recording of the size, motion, and composition of the heart and surrounding tissues. The standard approach is transthoracic.
The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.

Nonlinear indicial response of complex nonstationary oscillations as pulmonary hypertension responding to step hypoxia. (1/2234)

This paper is devoted to the quantization of the degree of nonlinearity of the relationship between two biological variables when one of the variables is a complex nonstationary oscillatory signal. An example of the situation is the indicial responses of pulmonary blood pressure (P) to step changes of oxygen tension (DeltapO2) in the breathing gas. For a step change of DeltapO2 beginning at time t1, the pulmonary blood pressure is a nonlinear function of time and DeltapO2, which can be written as P(t-t1 | DeltapO2). An effective method does not exist to examine the nonlinear function P(t-t1 | DeltapO2). A systematic approach is proposed here. The definitions of mean trends and oscillations about the means are the keys. With these keys a practical method of calculation is devised. We fit the mean trends of blood pressure with analytic functions of time, whose nonlinearity with respect to the oxygen level is clarified here. The associated oscillations about the mean can be transformed into Hilbert spectrum. An integration of the square of the Hilbert spectrum over frequency yields a measure of oscillatory energy, which is also a function of time, whose mean trends can be expressed by analytic functions. The degree of nonlinearity of the oscillatory energy with respect to the oxygen level also is clarified here. Theoretical extension of the experimental nonlinear indicial functions to arbitrary history of hypoxia is proposed. Application of the results to tissue remodeling and tissue engineering of blood vessels is discussed.  (+info)

Pulmonary capillary perfusion: intra-alveolar fractal patterns and interalveolar independence. (2/2234)

Pulmonary capillary perfusion was analyzed from videomicroscopic recordings to determine flow switching characteristics among capillary segments in isolated, blood-perfused canine lungs. Within each alveolus, the rapid switching pattern was repetitive and was, therefore, nonrandom (fractal dimensions near 1.0). This self-similarity over time was unexpected in a network widely considered to be passive. Among adjacent alveoli, the relationship among the switching patterns was even more surprising, for there was virtually no relationship between the perfusion patterns (coefficients of determination approaching zero). These findings demonstrated that the perfusion patterns in individual alveolar walls were independent of their next-door neighbors. The lack of dependence among neighboring networks suggests an interesting characteristic: the failure of one alveolar-capillary bed would leave its neighbors relatively unaffected, a feature of a robust design.  (+info)

Lactate kinetics at rest and during exercise in lambs with aortopulmonary shunts. (3/2234)

In a previous study [G. C. M. Beaufort-Krol, J. Takens, M. C. Molenkamp, G. B. Smid, J. J. Meuzelaar, W. G. Zijlstra, and J. R. G. Kuipers. Am. J. Physiol. 275 (Heart Circ. Physiol. 44): H1503-H1512, 1998], a lower systemic O2 supply was found in lambs with aortopulmonary left-to-right shunts. To determine whether the lower systemic O2 supply results in increased anaerobic metabolism, we used [1-13C]lactate to investigate lactate kinetics in eight 7-wk-old lambs with shunts and eight control lambs, at rest and during moderate exercise [treadmill; 50% of peak O2 consumption (VO2)]. The mean left-to-right shunt fraction in the shunt lambs was 55 +/- 3% of pulmonary blood flow. Arterial lactate concentrations and the rate of appearance (Ra) and disappearance (Rd) of lactate were similar in shunt and control lambs, both at rest (lactate: 1, 201 +/- 76 vs. 1,214 +/- 151 micromol/l; Ra = Rd: 12.97 +/- 1.71 vs. 12.55 +/- 1.25 micromol. min-1. kg-1) and during a similar relative workload. We found a positive correlation between Ra and systemic blood flow, O2 supply, and VO2 in both groups of lambs. In conclusion, shunt lambs have similar lactate kinetics as do control lambs, both at rest and during moderate exercise at a similar fraction of their peak VO2, despite a lower systemic O2 supply.  (+info)

Validation of haemodialysis recirculation and access blood flow measured by thermodilution. (4/2234)

BACKGROUND: Recirculation (R) and access blood flow (Qac) measurements are considered useful indicators of adequate delivery of haemodialysis. It was the purpose of this study to compare measurements of R and Qac obtained by two different techniques which are based on the same principle of indicator dilution, but which differ because of the characteristics of the injection and detection of the different indicators used. METHODS: Recirculation measured by a thermal dilution technique using temperature sensors (BTM, Fresenius Medical Care) was compared with recirculation measured by a validated saline dilution technique using ultrasonic transducers placed on arterial and venous segments of the extracorporeal circulation (HDM, Transonic Systems, Inc.). Calculated access flows were compared by Bland Altman analysis. Data are given as mean +/- SD. RESULTS: A total of 104 measurements obtained in 52 treatments (17 patients, 18 accesses) were compared. Recirculation measured with correct placement of blood lines and corrected for the effect of cardiopulmonary recirculation using the 'double recirculation technique' was -0.02 +/- 0.14% by the BTM technique and not different from the 0% measured by the HDM technique. Recirculation measured with reversed placement of blood lines and corrected for the effect of cardiopulmonary recirculation was 19.66 +/- 10.77% measured by the BTM technique compared with 20.87 +/- 11.64% measured by the HDM technique. The difference between techniques was small (-1.21 +/- 2.44%) albeit significant. Access flow calculated from BTM recirculation was 1328 +/- 627 ml/min compared with 1390 +/- 657 ml/min calculated by the HDM technique. There was no bias between techniques. CONCLUSION: BTM thermodilution yields results which are consistent with the HDM ultrasound dilution technique with regard to both recirculation and access flow measurement.  (+info)

Inducible NO synthase inhibition attenuates shear stress-induced pulmonary vasodilation in the ovine fetus. (5/2234)

Recent studies have suggested that type II (inducible) nitric oxide (NO) synthase (NOS II) is present in the fetal lung, but its physiological roles are uncertain. Whether NOS II activity contributes to the NO-mediated fall in pulmonary vascular resistance (PVR) during shear stress-induced pulmonary vasodilation is unknown. We studied the hemodynamic effects of two selective NOS II antagonists [aminoguanidine (AG) and S-ethylisothiourea (EIT)], a nonselective NOS antagonist [nitro-L-arginine (L-NNA)], and a nonselective vasoconstrictor (U-46619) on PVR during partial compression of the ductus arteriosus (DA) in 20 chronically prepared fetal lambs (mean age 132 +/- 2 days, term 147 days). At surgery, catheters were placed in the left pulmonary artery (LPA) for selective drug infusion, an ultrasonic flow transducer was placed on the LPA to measure blood flow, and an inflatable vascular occluder was placed loosely around the DA for compression. On alternate days, a brief intrapulmonary infusion of normal saline (control), AG, EIT, L-NNA, or U-46619 was infused in random order into the LPA. The DA was compressed to increase mean pulmonary arterial pressure (MPAP) 12-15 mmHg above baseline values and held constant for 30 min. In control studies, DA compression reduced PVR by 42% from baseline values (P < 0.01). L-NNA treatment completely blocked the fall in PVR during DA compression. AG and EIT attenuated the decrease in PVR by 30 and 19%, respectively (P < 0.05). Nonspecific elevation in PVR by U-46619 did not affect the fall in PVR during DA compression. Immunostaining for NOS II identified this isoform in airway epithelium and vascular smooth muscle in the late-gestation ovine fetal lung. We conclude that selective NOS II antagonists attenuate but do not block shear stress-induced vasodilation in the fetal lung. We speculate that stimulation of NOS II activity, perhaps from smooth muscle cells, contributes in part to the NO-mediated fall in PVR during shear stress-induced pulmonary vasodilation.  (+info)

RSR13, an allosteric effector of haemoglobin, and carbogen radiosensitize FSAII and SCCVII tumours in C3H mice. (6/2234)

Pre-clinical evaluation has demonstrated that 2-[4-(((3,5-dimethylanilino)carbonyl)methyl)phenoxy]-2-methylpropi onic acid (RSR13) acts as an allosteric effector of haemoglobin (Hb). RSR13 binding to Hb results in decreased haemoglobin-oxygen (Hb-O2) affinity, improved tumour oxygenation, and enhanced radiation-induced cell killing in several experimental tumour systems. In the present work, ex vivo clonogenic survival analyses are applied in two murine tumour systems to characterize the relationship between the magnitude of decrease in Hb-O2 affinity and radiosensitization, the influence of inspired pO2 upon this effect, and the efficacy of combining RSR13 and radiation during a course of repeated radiation exposures. For FSaII tumours in C3H mice breathing air, 100 mg kg(-1) RSR13 administered intraperitoneally produced an enhancement ratio (ER) of 1.3, but there was marked desensitization at a RSR13 dose of 300 mg kg(-1) (ER 0.6). The most likely reason for the increased radioresistance was insufficient oxygen loading of Hb in the pulmonary circulation due to reduced haemoglobin-oxygen affinity because carbogen breathing combined with 300 mg kg(-1) RSR13 reversed the effect and produced an ER of 1.8. In SCCVII tumours in C3H mice irradiated with eight fractions of 2.5 Gy over 4 days, the surviving fraction was reduced to 58-67% of control values when RSR13 was combined with radiation on days 1 and 2, days 3 and 4, or days 1-4. These results confirm that combining RSR13 and irradiation within a fractionated course of clinically relevant low-dose exposures provides significant radiosensitization. Additional preclinical experimentation is needed to define better the optimum dose-scheduling conditions for clinical applications.  (+info)

Effects of isoflurane anesthesia on pulmonary vascular response to K+ ATP channel activation and circulatory hypotension in chronically instrumented dogs. (7/2234)

BACKGROUND: The objective of this study was to evaluate the effects of isoflurane anesthesia on the pulmonary vascular responses to exogenous adenosine triphosphate-sensitive potassium (K+ ATP) channel activation and circulatory hypotension compared with responses measured in the conscious state. In addition, the extent to which K+ ATP channel inhibition modulates the pulmonary vascular response to circulatory hypotension in conscious and isoflurane-anesthetized dogs was assessed. METHODS: Fifteen conditioned, male mongrel dogs were fitted with instruments for long-term monitoring to measure the left pulmonary vascular pressure-flow relation. The dose-response relation to the K+ ATP channel agonist, lemakalim, and the pulmonary vascular response to circulatory hypotension were assessed in conscious and isoflurane-anesthetized (approximately 1.2 minimum alveolar concentration) dogs. The effect of the selective K+ ATP channel antagonist, glibenclamide, on the pulmonary vascular response to hypotension was also assessed in conscious and isoflurane-anesthetized dogs. RESULTS: Isoflurane had no effect on the baseline pulmonary circulation, but it attenuated (P<0.05) the pulmonary vasodilator response to lemakalim. Reducing the mean systemic arterial pressure to approximately 50 mm Hg resulted in pulmonary vasoconstriction (P<0.05) in the conscious state, and this response was attenuated (P<0.05) during isoflurane. Glibenclamide had no effect on the baseline pulmonary circulation, but it potentiated (P<0.05) the pulmonary vasoconstrictor response to hypotension in conscious and isoflurane-anesthetized dogs. CONCLUSIONS: These results indicate that K+ ATP-mediated pulmonary vasodilation and the pulmonary vasoconstrictor response to hypotension are attenuated during isoflurane anesthesia. Endogenous K+ ATP channel activation modulates the pulmonary vasoconstrictor response to hypotension in the conscious state, and this effect is preserved during isoflurane anesthesia.  (+info)

Combined effects of nitric oxide and oxygen during acute pulmonary vasodilator testing. (8/2234)

OBJECTIVES: We compared the ability of inhaled nitric oxide (NO), oxygen (O2) and nitric oxide in oxygen (NO+O2) to identify reactive pulmonary vasculature in pulmonary hypertensive patients during acute vasodilator testing at cardiac catheterization. BACKGROUND: In patients with pulmonary hypertension, decisions regarding suitability for corrective surgery, transplantation and assessment of long-term prognosis are based on results obtained during acute pulmonary vasodilator testing. METHODS: In group 1, 46 patients had hemodynamic measurements in room air (RA), 100% O2, return to RA and NO (80 parts per million [ppm] in RA). In group 2, 25 additional patients were studied in RA, 100% O2 and 80 ppm NO in oxygen (NO+O2). RESULTS: In group 1, O2 decreased pulmonary vascular resistance (PVR) (mean+/-SEM) from 17.2+/-2.1 U.m2 to 11.1+/-1.5 U.m2 (p < 0.05). Nitric oxide caused a comparable decrease from 17.8+/-2.2 U.m2 to 11.7+/-1.7 U.m2 (p < 0.05). In group 2, PVR decreased from 20.1+/-2.6 U.m2 to 14.3+/-1.9 U.m2 in O2 (p < 0.05) and further to 10.5+/-1.7 U.m2 in NO+O2 (p < 0.05). A response of 20% or more reduction in PVR was seen in 22/25 patients with NO+O2 compared with 16/25 in O2 alone (p = 0.01). CONCLUSIONS: Inhaled NO and O2 produced a similar degree of selective pulmonary vasodilation. Our data suggest that combination testing with NO + O2 provides additional pulmonary vasodilation in patients with a reactive pulmonary vascular bed in a selective, safe and expeditious fashion during cardiac catheterization. The combination of NO+O2 identifies patients with significant pulmonary vasoreactivity who might not be recognized if O2 or NO were used separately.  (+info)

1.Inhaled vasodilators such as nitric oxide and epoprostenol (prostaglandin I2) are now widely employed as supportive therapies to improve oxygenation and reduce pulmonary vascular resistance in patients with acute and chronic pulmonary hypertension. However, few data exist concerning their effects in normal individuals. The aim of this study was to characterize the response of the pulmonary circulation in normal individuals to inhaled nitric oxide and nebulized prostaglandin I2.. 2.Eight healthy volunteers were exposed to inhaled nitric oxide (0, 20 and 40 ;p.p.m.) and nebulized prostaglandin I2 (10 ;μg/ml). Changes in effective pulmonary blood flow and diffusing capacity of the lung for carbon monoxide (TLCO) were measured using respiratory mass spectrometry. Bicycle ergometry was used to increase effective pulmonary blood flow as a positive control.. 3.Exercise produced significant increases in both effective pulmonary blood flow and TLCO, but neither nitric oxide nor prostaglandin I2 ...
Pulmonary capillary blood flow was measured in man during slow breathing by a modification of the body plethysmograph technique for measuring N2O uptake. In seated subjects breathing slowly, flow was significantly higher during inhalation. In supine subjects whose legs were raised, the difference between inhalation and exhalation was not significant. Flow was usually greater during tidal inhalation than exhalation, but there was considerable variation. The changes in flow were not directly related to intrathoracic pressures or lung volumes. The results suggest that it is the amount and pressure of the venous blood available for aspiration into the thorax that influences pulmonary capillary blood flow during the course of a respiratory cycle.. ...
Effect of a sustained inflation on oxygenation and regional pulmonary perfusion in a lavage model of acute lung injury. Am J Resp Crit Care Med. 2001; 163(5):A675 ...
Apparatus and methods for non-invasively determining the cardiac output or pulmonary capillary blood flow of a patient using partial re-breathing techniques. The apparatus includes a substantially instantaneously adjustable deadspace volume for accommodating differences in sizes or breathing capacities of various patients. The apparatus may be constructed of inexpensive elements, including one or more two-way valves, which render the apparatus very simple to use and inexpensive so that the unit may be employed as a disposable product. The method of the invention includes estimating the cardiac output or pulmonary capillary blood flow of a patient based on partial pressure of alveolar CO2 rather than on the partial pressure of end tidal CO2, as previously practiced. A computer program for calculating the cardiac output or pulmonary capillary blood flow of a patient is also disclosed.
TY - JOUR. T1 - Effect of catecholamines on pulmonary circulation at elevated vascular tone. AU - Barman, S. A.. PY - 1995/1/1. Y1 - 1995/1/1. N2 - The effect of catecholamine stimulation on the longitudinal resistance and compliance distribution in the canine pulmonary vasculature was evaluated under control vascular tone and after vascular tone was elevated using the thromboxane analogue U-46619. The arterial-, venous-, and double-occlusion techniques were used to measure the segmental resistances and compliances in isolated dog lung blood perfused at constant flow. The results of this study indicate that at control vascular tone the catecholamines norepinephrine and epinephrine increase pulmonary vascular resistance and decrease pulmonary vascular compliance through α1- and α2-receptor-mediated stimulation with precapillary α1- and α2-receptors and postcapillary α2-receptors interacting with precapillary and postcapillary β2-receptors. In addition, epinephrine appears to have a greater ...
Looking for pulmonary circulation? Find out information about pulmonary circulation. The circulation of blood through the lungs for the purpose of oxygenation and the release of carbon dioxide. Also known as lesser circulation Explanation of pulmonary circulation
TY - JOUR. T1 - Alterations in TGF-β1 expression in lambs with increased pulmonary blood flow and pulmonary hypertension. AU - Mata-Greenwood, Eugenia. AU - Meyrick, Barbara. AU - Steinhorn, Robin H.. AU - Fineman, Jeffrey R.. AU - Black, Stephen M.. PY - 2003/7/1. Y1 - 2003/7/1. N2 - The mechanisms responsible for pulmonary vascular remodeling in congenital heart disease with increased pulmonary blood flow remain unclear. We developed a lamb model of congenital heart disease and increased pulmonary blood flow utilizing an in utero placed aortopulmonary vascular graft (shunted lambs). Morphometric analysis of barium-injected pulmonary arteries indicated that by 4 wk of age, shunts had twice the pulmonary arterial density of controls (P , 0.05), and their pulmonary vessels showed increased muscularization and medial thickness at both 4 and 8 wk of age (P , 0.05). To determine the potential role of TGF-β1 in this vascular remodeling, we investigated vascular changes in expression and ...
TY - CHAP. T1 - Development of the Pulmonary Endothelium in Development of the Pulmonary Circulation. T2 - Vasculogenesis and Angiogenesis. AU - Schwarz, Margaret. AU - Cleaver, Ondine B.. PY - 2009/9/11. Y1 - 2009/9/11. KW - Angiogenesis and vasculogenesis in developing lung. KW - Arterial versus venous differentiation. KW - Blood islands and hemangioblasts. KW - Endothelial-specific factors. KW - Pulmonary endothelium and pulmonary circulation. KW - Sprouting angiogenesis. KW - Tubulogenesis. KW - Vascular cell ontogeny. KW - Vasculogenesis. KW - VEGF-A and isoforms. UR - http://www.scopus.com/inward/record.url?scp=84889270740&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=84889270740&partnerID=8YFLogxK. U2 - 10.1002/9780470747490.ch1. DO - 10.1002/9780470747490.ch1. M3 - Chapter. AN - SCOPUS:84889270740. SN - 9780470723616. SP - 1. EP - 24. BT - The Pulmonary Endothelium: Function in health and disease. PB - John Wiley & Sons, Ltd. ER - ...
To determine the potential contribution of endothelin (ET) to modulation of high pulmonary vascular resistance in the normal fetus, we studied the effects of BQ 123, a selective ET-A receptor antagonist, and sarafoxotoxin S6c (SFX), a selective ET-B receptor agonist, in 31 chronically prepared late gestation fetal lambs. Brief intrapulmonary infusions of BQ 123 (0.1-1.0 mcg/min for 10 min) caused sustained increases in left pulmonary artery flow (Qp) without changing main pulmonary artery (MPA) and aortic (Ao) pressures. In contrast, BQ 123 did not change vascular resistance in a regional systemic circulation (the fetal hindlimb). To determine whether big-endothelin-1 (big-ET-1)-induced pulmonary vasoconstriction is mediated by ET-A receptor stimulation, we studied the effects of big-ET-1 with or without pretreatment with BQ 123. BQ 123 (0.5 mcg/min for 10 min) blocked the rise in total pulmonary resistance caused by big-ET-1. CGS 27830 (100 mcg/min for 10 min), an ET-A and -B receptor ...
In primary pulmonary hypertension, the cause is unknown, but the abnormal changes associated with blood vessels in the lungs. Secondary pulmonary hypertension is a complication of many diseases of the lungs, heart and chest cavity. Cor pulmonale is a consequence of prolonged high blood pressure in the pulmonary circulation in which the right ventricle has become enlarged. Right ventricle is relatively thin and have limited ability to appreciate, therefore, the right side of the heart could begin to fail if blood pressure in the pulmonary circulation are persistently high. It occurs when the right-sided heart failure ...
TY - JOUR. T1 - Effect of Sildenafil on the acute pulmonary vasodilator response to inhaled nitric oxide in adults with primary pulmonary hypertension. AU - Lepore, John J.. AU - Maroo, Anjli. AU - Pereira, Naveen Luke. AU - Ginns, Leo C.. AU - Dec, G. William. AU - Zapol, Warren M.. AU - Bloch, Kenneth D.. AU - Semigran, Marc J.. PY - 2002/9/15. Y1 - 2002/9/15. UR - http://www.scopus.com/inward/record.url?scp=0037106989&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=0037106989&partnerID=8YFLogxK. U2 - 10.1016/S0002-9149(02)02586-9. DO - 10.1016/S0002-9149(02)02586-9. M3 - Article. C2 - 12231108. AN - SCOPUS:0037106989. VL - 90. SP - 677. EP - 680. JO - American Journal of Cardiology. JF - American Journal of Cardiology. SN - 0002-9149. IS - 6. ER - ...
Pulmonary Circulations first Impact Factor will be released in June 2017. Since its launch in 2011, our journal has become established as a unique venue of communication for clinical, translational and basic research in the fields of pulmonary circulation and pulmonary vascular disease.
TY - JOUR. T1 - Relative dispersion in the Liguro-Provençal basin. T2 - From sub-mesoscale to mesoscale. AU - Schroeder, K.. AU - Haza, A. C.. AU - Griffa, A.. AU - Özgökmen, T. M.. AU - Poulain, P. M.. AU - Gerin, R.. AU - Peggion, G.. AU - Rixen, M.. PY - 2011/3/1. Y1 - 2011/3/1. N2 - Relative dispersion in the Liguro-Provençal basin (a subregion of the Mediterranean Sea) is investigated using clusters of surface drifters deployed during two Marine Rapid Environment Assessment (MREA) experiments covering different months in 2007 and 2008, respectively. The clusters have initial radii of less than 1km, or an order of magnitude below a typical deformation radius (approximately 10-20km). The data set consists of 45 original pairs and more than 50 total pairs (including chance ones) in the spatial range between 1 and 200km. Relative dispersion is estimated using the mean square separation of particle pairs and the Finite Scale Lyapunov Exponents (FSLEs). The two metrics show broadly consistent ...
The purpose of this study is to determine and compare changes in lung diffusing capacity, cardiac output, and pulmonary vascular pressures during exercise for younger versus older individuals. It is possible that the blood vessels of the lungs play a greater role in unexplained exercise intolerance and shortnesss of breath in older individuals than previously thought.. ...
Pulmonary circulation refers to the blood circulation between the heart and the lungs. The pulmonary arteries carry deoxygenated blood away from the heart into the lungs for oxygen renewal, and then the pulmonary veins take the oxygenated blood from the lungs back to the heart, and from there the oxygen is distrubuted throughout the entire body.. Two bronchi branch off from the trachea, commonly known as the windpipe, and one bronchus enters each lung. Inside the lungs the bronchi branch out into a further three, and from here into smaller structures known as bronchioles.. The lungs are divided into lobes which are marked by fissures. The left lung consists of two lobes, the superior and the inferior, and the right lung comprises of three, the superior, middle and the inferior.. Each lobe is made up of a vast number of lobules, and these consist of terminal and respiratory bronchioles, alveolar ducts and alveoli. It is within the alveoli, which are tiny air sacs, that the renewal of blood oxygen ...
Semantic Scholar extracted view of Atropine Effects upon Blood Pressure in the Pulmonary Circulation of Cats after Application of Ganglioplegic Drugs. by J H Ryzewski et al.
This is a record of the proceedings of an international group of physiologists, pathologists, and clinicians gathered to consider the pulmonary circulation in h
The third edition of The Human Pulmonary Circulation: Its Form and Function in Health and Disease by Peter Harris, MD, and Donald Heath, MD, is a classic textbo
Study Flashcards On physioreview27(Pulmonary circulation) at Cram.com. Quickly memorize the terms, phrases and much more. Cram.com makes it easy to get the grade you want!
Fingerprint Dive into the research topics of Spatial distribution of pulmonary blood flow in dogs in increased force environments. Together they form a unique fingerprint. ...
in Critical Care Medicine (1992), 20(7), 1005-13. BACKGROUND AND METHODS: We aimed to characterize the effects of an endotoxin insult (Escherichia coli 0127:B8) on the relationships between pulmonary vascular pressure and flow in intact dogs. To achieve ... [more ▼]. BACKGROUND AND METHODS: We aimed to characterize the effects of an endotoxin insult (Escherichia coli 0127:B8) on the relationships between pulmonary vascular pressure and flow in intact dogs. To achieve this goal, multipoint plots of total pressure gradient, arterial pressure gradient, and venous pressure gradient vs. flow were generated by graded inflation of a right atrial balloon, which was used to vary flow. The partitioning of the total pressure decrease across the pulmonary vasculature (total pressure gradient = pulmonary arterial pressure-pulmonary artery occlusion pressure [PAOP]) into gradients across pulmonary arterial (arterial pressure gradient = pulmonary arterial pressure--effective capillary pressure) and pulmonary ...
To the Editor:. Multidetector computed tomography (MDCT) is frequently used as the first-line technique to directly visualize pulmonary embolism (PE) with a reported sensitivity and specificity of 83% to 100% and 89% to 97%, respectively (1). However, for rapid and profound clinical decision making and prognostication, accurate detection of right ventricular (RV) dysfunction and pulmonary perfusion impairment remains pivotal because such patients are at higher risk of an adverse outcome (2).. The present study used a single-session, multicomponent cardiovascular magnetic resonance (CMR) imaging protocol facilitating, first, the visualization of pulmonary thrombi; second, the precise evaluation of RV volumes/function; and third, pulmonary perfusion on a parenchymal level.. Twelve patients (5 men; mean age, 63.1 ± 19.8 years) with documented PE on contrast-enhanced MDCT (Somatom Sensation 64, Siemens Medical Solutions, Forchheim, Germany) and 14 healthy controls (7 men; mean age, 39.3 ± 16.0 ...
It has been generally thought that PH predominantly resulted from hypoxia-induced structural changes in the pulmonary vasculature, which produced a fixed increase in resistance. These structural changes included remodeling of the arteriolar walls leading to encroachment into the vascular lumen, and loss of blood vessels, suggesting that interventions, which successfully ameliorated PH, would act by preventing or reversing such structural changes. The results of the present study cast doubt on this paradigm by demonstrating that chronic hypoxia did not cause a structurally based reduction of pulmonary vascular lumen diameter, nor did it cause a loss of pulmonary vessels. Moreover, we report that chronic inhibition of ROCK abrogated the development of hypoxic PH, not by preventing structural encroachment into the vascular lumen, but by inhibiting sustained pulmonary vasoconstriction. Importantly, we also found hypoxia-induced capillary angiogenesis in the adult lung that was dependent on the ...
Download Ebook Pulmonary Circulation pdf Free Download Ebook Get it $10 USD Authoritative, comprehensive and definitive, Pulmonary Circulation builds on the success of its previous two editions by providing practising respiratory physicians with a highly-ordered, unique reference work on the structure, function and pathophysiology of the pulmonary circulation. New for .... Read More » ...
Affiliation:千葉大学,医学部,助手, Research Field:Respiratory organ internal medicine,呼吸器内科学, Keywords:Pulmonary microcirculation,肺微小循環,Pulmonary circulation,摘出分離潅流肺,Pulmonary capillary,肺循環,肺毛細血管,生体顕微鏡,摘出分離灌流肺,低酸素性肺血管攣縮, # of Research Projects:3, # of Research Products:0
This article is provided by the Pulmonary Vascular Research Institute (PVRI). In this volume, the evolution of our current understanding of a number of areas of pulmonary function, both the physiology and the pathophysiology, are explained. The authors were specifically instructed to write in plain English and not to obfuscate the material with equations. This elite group of scientists succeeded brilliantly.
Author: Möller, Harald E. et al.; Genre: Poster; Title: Absolute quantification of pulmonary perfusion using intravenous injection of hyperpolarized 129Xe
TY - JOUR. T1 - Seroma is a quite frequent complication of systemic to pulmonary shunts with tubular prostheses. AU - Marianeschi, S. M.. AU - Mazzera, E.. AU - Picardo, S.. AU - Giamberti, A.. AU - Corno, A.. AU - Marcelletti, C.. PY - 1989. Y1 - 1989. UR - http://www.scopus.com/inward/record.url?scp=0024638895&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=0024638895&partnerID=8YFLogxK. M3 - Article. C2 - 2743369. AN - SCOPUS:0024638895. VL - 34. SP - 271. EP - 274. JO - Cardiologia (Rome, Italy). JF - Cardiologia (Rome, Italy). SN - 0393-1978. IS - 3. ER - ...
Ellibs Ebookstore - Ebook: Pulmonary Vasculature Redox Signaling in Health and Disease - Author: Wang, Yong-Xiao (#editor) - Price: 230,65€
Study Flashcards On Physiology - CH 21 - Blood Vessels & Circulation at Cram.com. Quickly memorize the terms, phrases and much more. Cram.com makes it easy to get the grade you want!
a new Closed Circulation Lab The Closed Circulation Lab models the entire circulatory loop: left ventricle, peripheral circulation, right ventricle, and pulmonary circulation. Both models include numerous input parameters that can be controlled by the user. Some of these parameters are shown in Figures 1 and 2. By manipulating these physiological variables, students can design experiments to investigate a variety of questions concerning how changes affect the performance of the heart. ...
The human circulatory system is double: A pulmonary circulation (to the lungs, blood is oxygenated) A systemic circulation (to the rest of the body, where oxygen is consumed). Learn their anatomy, and how they work together with the heart in this video!
While only representative of a single individual in the trial, these data are very exciting, said Dr. June. They demonstrate that the ZFN-modified T-cells were well tolerated by the body and persisted in the circulation at stable levels for the duration of our monitoring. In fact, we calculate that more ZFN-modified cells were present at 20 weeks than were initially infused. Total CD4+ T-cell counts were also stable during this time. Interestingly, we also observed ZFN-modified cells in the gut associated lymphoid tissue (GALT) which is a major reservoir of immune cells and a critical reservoir of HIV infection and suggests that the modified cells are functioning and trafficking normally in the body ...
Way back in the late 1990s, when I ran circulation at Eddie Bauer, we introduced new creative - younger models, branding, less product density. It was a disaster ... -10% across the board. It is very painful to lose $60,000,000 demand and $15,000,000 profit because of creative changes. Very painful. No bonuses for managerial employees because of the decisions of two or three people. Twelve to eighteen months of pain is all it takes before you reverse course ... and then its terribly hard to make up the $60,000,000 demand and $15,000,000 profit. But, again, well never know if you lose $60,000,000 demand every year, or if in three years, you are posting $90,000,000 positives once customers get used to the change. ...
The CLASSIC KFC1.5 is a furler that can withstand a workload of 1.5 T. It is intented for sailboats from 25 to 35 feet. The KFC1.5 is a
How many times does this have to happen before we all stop going to KFC? Hopefully twice is the answer. Three weeks ago a teenager in the UK thought he had
TY - JOUR. T1 - Effects of S-nitrosation and cross-linking of hemoglobin on hypoxic pulmonary vasoconstriction in isolated rat lungs. AU - Deem, Steven. AU - Kim, Joung Uk. AU - Manjula, Belur N.. AU - Acharya, A. Seetharama. AU - Kerr, Mark E.. AU - Patel, Rakesh P.. AU - Gladwin, Mark T.. AU - Swenson, Erik R.. PY - 2002/10/4. Y1 - 2002/10/4. N2 - Free hemoglobin (Hb) and red blood cells augment hypoxic pulmonary vasoconstriction (HPV) by scavenging nitric oxide (NO). S-nitrosation of Hb (SNO-Hb) may confer vasodilatory properties by allowing release of NO during deoxygenation and/or by interaction with small-molecular weight thiols. Likewise, cross-linking of free Hb may limit its vasoconstrictive effect by preventing abluminal movement of the molecule. We compared the effects of free SNO-Hb and Hb intramolecularly cross-linked at the β-cysteine 93 residue [Bis(maleidophenyl)-polyethylene glycol2000HbA (Bis-Mal-PEGHb)] to those of free oxyHb on pulmonary artery pressure (PAP), HPV, and ...
BACKGROUND: Hypoxic pulmonary vasoconstriction (HPV) is a defense mechanism to maintain adequate oxygenation. It has been reported that metabolism inhibition augments HPV. The purpose of the present study was, therefore, to determine the effect of metabolism inhibition on HPV in a rabbit model of isolated lung perfusion with exclusion of the influential factors on HPV. METHODS: In adult rabbits, lungs were isolated and perfused with a constant pulmonary perfusate flow. Acid-base status and temperature of perfusate was also constantly maintained. Thirty minutes after, the baseline hypoxic pressor response (HPR) was measured as the difference of pulmonary artery pressure (PAP) between a period of 21% normoxic gas inhalation and that of 3% hypoxic gas inhalation. After another thirty minutes, 2-deoxy-D-glucose 100 mg was mixed with the perfusate, and then HPR was measured three times. After checking metabolism inhibition effects, D-glucose 300 mg was mixed to the perfusate to reverse metabolism ...
The time course of the pulmonary vascular response to hypoxia in humans has not been fully defined. In this investigation, study A was designed to assess the form of the increase in pulmonary vascular tone at the onset of hypoxia and to determine whether a steady plateau ensues over the following approximately 20 min. Twelve volunteers were exposed twice to 5 min of isocapnic euoxia (end-tidal Po(2) = 100 Torr), 25 min of isocapnic hypoxia (end-tidal Po(2) = 50 Torr), and finally 5 min of isocapnic euoxia. Study B was designed to look for the onset of a slower pulmonary vascular response, and, if possible, to determine a latency for this process. Seven volunteers were exposed to 5 min of isocapnic euoxia, 105 min of isocapnic hypoxia, and finally 10 min of isocapnic euoxia. For both studies, control protocols consisting of isocapnic euoxia were undertaken. Doppler echocardiography was used to measure cardiac output and the maximum tricuspid pressure gradient during systole, and estimates of pulmonary
Radionuclide lung perfusion imaging was performed on 27 patients with valvular disease of the left heart. The ratio of upper to total counts for the lungs, determined by computer, was correlated against pulmonary vascular mean pressures. A close correlation (r = 0.91) was obtained against pulmonary wedge pressure. After corrective cardiac surgery upper/total ratios fell towards normal in four patients in whom pulmonary vascular pressures were measured and the correlation persisted. This simple non-invasive index can be used to follow changes in pulmonary venous hypertension. ...
TY - JOUR. T1 - Pulmonary perfusion with L-arginine ameliorates post-cardiopulmonary bypass lung injury in a rabbit model. AU - Chao, Yin Kai. AU - Wu, Yi Cheng. AU - Yang, Kun Ju. AU - Chiang, Ling Ling. AU - Liu, Hui Ping. AU - Lin, Pyng Jing. AU - Chu, Yen. PY - 2011/5/15. Y1 - 2011/5/15. N2 - Background: Post-cardiopulmonary bypass (CPB) lung injury is the combination of whole body inflammatory response and local ischemia-reperfusion (IR) injury. We investigated the benefit of pulmonary perfusion with L-arginine in protection against post-CPB lung injury. Methods: New Zealand white rabbits (n = 50, weight, 2.5-2.8 kg) were divided into five groups (n = 10 each): sham (sham sternotomy), CPB (CPB without pulmonary perfusion), perfusion (CPB with pulmonary perfusion), L-arginine (CPB with perfusion + L-arginine), and L-NAME (CPB with perfusion + L-NAME). The duration of CPB was 60 min followed by 2 h of reperfusion. Pulmonary perfusion was performed every 20 min through the pulmonary artery ...
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We will use a method to analyze the length-scale of perfusion heterogeneity before and after surgery for CTEPH. Briefly, this method consists of filtering the images with filters of different spatial size (length, mm) and measuring the coefficient of variation (CV) of perfusion in the imaged field. We then bin the CV into the following intervals: 12-36 mm, 36-60 mm, 60-84 mm, 84-108 mm and ,108 mm and compare the CV in each bin among subjects ...
Although electrocardiographic evidence of right ventricular hypertrophy is considered common in newborn infants with coarctation of the aorta, the reason for this finding is not well established. Investigations of the pulmonary vascular bed of these infants have resulted in variable findings, probably due to the differences in morphometric techniques, coexisting cardiac defects, and variable postnatal age at time of death. To study more carefully the pulmonary vascular bed, we produced coarctation of the aorta in fetal lambs at 103--126 days gestation. Twelve to 32 days later the fetuses were reoperated on and systemic and pulmonary arterial blood pressures, and arterial blood gas tensions were determined to be normal. At autopsy, juxtaductal coarctations extended a mean of 2.8 mm into the aortic lumen and occupied 9.5 mm of the aortic circumference. The fifth-generation pulmonary resistance vessels had increased medial width (p less than 0.01), decreased external diameter (p less than 0.001), ...
The clinical findings, occupational exposure, smoking history, pulmonary function, chest radiograph and ventilation-perfusion studies have been examined in 12 men exposed to asbestos fibers in the course of their work. Minor abnormalities of regional ventilation, consistent with early small airway dysfunction, were found in the fibrotic zones of most of the nonsmokers or mild cigarette smokers. The whole-lung washout times, estimated by visual inspection of serial washout images, were strongly correlated with measurements of airflow obstruction, but not with pack-years of smoking. There was a close correspondence between radiographic extent of pulmonary fibrosis and the abnormalities in pulmonary blood flow in these regions. The severity of the abnormalities in regional pulmonary blood flow was significantly correlated with the years of asbestos exposure (r = + 0.73, p less than 0.01). It is suggested that the magnitude of the disturbance in pulmonary blood flow in the fibrotic zones could be ...
Blood flow between these two vascular beds may not always be equal. If a state occurs in which pulmonary vascular resistance increases or systemic vascular resistance decreases blood will preferentially shift to the peripheral circulation at the expense of blood flow to the lungs. This is the pathophysiology behind the hypercyanotic spell (Tet spell) seen in children with tetralogy of Fallot and similar lesions. Increases in systemic vascular resistance or decreases in pulmonary vascular resistance will produce the opposite effect shunting blood to the pulmonary circulation at the expense of peripheral perfusion.. This may occur when a childs baseline state of hypoxic pulmonary hypertension is suddenly reversed with additional oxygen or assisted ventilations that decrease avelolar carbon dioxide concentrations.. In the patient presented, a univentricular heart distributed blood to both the pulmonary and systemic circulations. Dehydration and acidosis produced compensatory hyperventilation ...
Introduction: Severe chronic obstructive pulmonary disease (COPD) is often associated with secondary pulmonary hypertension (PH), which worsens prognosis. PH can be lowered by oxygen, but also by inhaled nitric oxide (NO), which has the potential to improve the health status of these patients. NO is an important mediator in vascular reactions in the pulmonary circulation. Oral compounds can act through NO-mediated pathways, but delivering pulsed inhaled NO (iNO) directly to the airways and pulmonary vasculature could equally benefit patients. Therefore, a proof-of-concept study was performed to quantify pulmonary blood vessel caliber changes after iNO administration using computed tomography (CT)-based functional respiratory imaging (FRI). Methods: Six patients with secondary PH due to COPD received pulsed iNO in combination with oxygen for 20 minutes via a nasal cannula. Patients underwent a high-resolution CT scan with contrast before and after iNO. Using FRI, changes in volumes of blood ...
We investigated the possible contributions of reactive oxygen species and of viscosity changes to hemodilution-induced inhibition of hypoxic pulmonary vasoconstriction (HPV) in dogs. Fourteen isoflurane-anesthetized dogs were randomly assigned to receive N-acetylcysteine (NAC) 200 mg/kg IV (n = 7) or placebo (n = 7). Mean pulmonary artery pressure (Ppa) was measured with cardiac output maintained constant by a manipulation of venous return in hyperoxia (fraction of inspired oxygen, 0.4) and in hypoxia (fraction of inspired oxygen, 0.1) at baseline and after stepwise reductions in hematocrit from 40% to 20%. Measured Ppa was compared with predicted Ppa by using a viscoelastic model. HPV was expressed as hypoxic Ppa minus hyperoxic Ppa. Hemodilution was associated with a decrease in HPV from 7 ± 1 mm Hg to 3 ± 1 mm Hg (P , 0.01), and this was completely prevented by NAC (HPV was unchanged, from 8 ± 1 to 8 ± 1 mm Hg; not significant). Hemodilution in the model decreased HPV from 8 ± 1 mm Hg to ...
Definition of Pulmonary vascular resistance in the Financial Dictionary - by Free online English dictionary and encyclopedia. What is Pulmonary vascular resistance? Meaning of Pulmonary vascular resistance as a finance term. What does Pulmonary vascular resistance mean in finance?
Regional alveolar hypoxia in the lung induces regional pulmonary vasoconstriction which diverts blood flow from the hypoxic area. However, the predominant determinant of the distribution of perfusion in the normal erect lung is gravity so that more perfusion occurs at the base than at the apex. To determine the strength of the regional alveolar hypoxic response in diverting flow with or against the gravity gradient a divided tracheal cannula was placed in anesthetized dogs and unilateral alveolar hypoxia created by venilating one lung with nitrogen while ventilating the other lung with oxygen to preserve normal systemic oxygentation. Scintigrams of the distribution of perfusion obtained with intravenous 13-N and the MGH positron camera revealed a 34 and 32 per cent decrease in perfusion to the hypoxic lung in the supine and erect positions and a 26 per cent decrease in the decubitus position with the hypoxic lung dependent (P equal to 0.94 from supine shift), indicating nearly equal vasoconstriction
Background-We compared the hemodynamic responses to inhibition or stimulation of endothelial nitric oxide (NO) release of isolated explanted lungs from transplantation recipients with pulmonary hypertension and in normotensive unallocated donor lungs.. Methods and Results-Lungs from 10 patients with severe pulmonary hypertension (SPH) and from 16 patients with severe chronic obstructive lung disease (COLD) were studied. Fourteen normotensive lungs were studied as controls. The lungs were perfused at a constant flow. In protocol 1 NG-nitro-l-arginine methyl ester caused a similar rise in baseline pulmonary artery pressure (PAP) that was similar in SPH (+17.1±4.2 mm Hg; n=5), COLD (+15.5±4.8 mm Hg; n=8), and control lungs (+14.5±1.5 mm Hg; n=7). Arterial occlusion demonstrated that most of the changes with NG-nitro-l-arginine methyl ester were precapillary. The response to sodium nitroprusside (10−8 to 10−4 mol/L) was similar in all groups. In protocol 2, the lungs were preconstricted, and ...
TY - JOUR. T1 - The LKB1-AMPK-α1 signalling pathway triggers hypoxic pulmonary vasoconstriction downstream of mitochondria. AU - Moral-Sanz, Javier. AU - Lewis, Sophronia A.. AU - MacMillan, Sandy. AU - Ross, Fiona A.. AU - Thomson, Adrian. AU - Viollet, Benoit. AU - Foretz, Marc. AU - Moran, Carmel. AU - Hardie, D. Grahame. AU - Evans, A. Mark. PY - 2018/10/2. Y1 - 2018/10/2. U2 - 10.1126/scisignal.aau0296. DO - 10.1126/scisignal.aau0296. M3 - Article. VL - 11. JO - Science Signaling. JF - Science Signaling. SN - 1945-0877. IS - 550. ER - ...
English Worksheets To Print - Pulmonary Circulation Worksheet. 2nd grade activities. math decimals worksheets for 6th grade. math word problems for kindergarten and first grade. 10 by 10 graph paper. math classes for toddlers.
Very early clamping results in less than physiologic blood volume. The normal, term child routinely survives, but clamping the cord of a compromised child before ventilation is riskier. Initial aeration of the lungs causes reflex dilatation of pulmonary arterioles and a massive increase in pulmonary blood flow. Placental transfusion normally supplies this volume. Clamping the cord before the infants first breath results in blood being sacrificed from other organs to establish pulmonary perfusion. Fatality may result if the child is already hypovolemic. Because placental transfusion patterns vary widely, it is futile to attempt to give the newborn the right amount of blood by clamping at a set time after birth. However, it is extremely likely that the infant will have less-than-optimal blood volume if the cord is clamped before the lungs are ventilated. In clinical practice, late clamping produces a high hematocrit, high blood pressure, and vasodilatation to accommodate the large volume of ...
Crocodiles have the most complex cardiovascular system among the vertebrates. With its unique design, it is believed that the crocodilian heart can function as a four chambered heart where the pressure and the flow is completely separated as in birds and mammals but has the ability to redirect the blood away from the lung circulation as needed.. In three chambered hearts found in other reptiles, blood is pumped from the undivided ventricle to both the lungs (pulmonary circulation) and the rest of the body (systemic circulation). Both circuits are connected in parallel and this makes it possible to distribute the blood pumped from the heart unevenly between the pulmonary and systemic circulation. Given this cardiac anatomy, animals with a three chambered heart are able to reduce or even stop the flow to the lungs and yet maintain or even increase blood flow to the systemic circulation. This is believed to be useful in situations when the lungs have no function, such as when the animals dive and ...
The normal adult pulmonary circulation is a low-pressure, high-capacity circuit. Pulmonary vascular resistance is regulated by alveolar oxygen tension, potassium channels and a variety of locally produced and circulating vasoactive factors. Perturbations of these systems may contribute to the pathogenesis of pulmonary hypertension. Recently, mutations in BMPR2 and ALK-1, genes that encode members of the transforming growth factor-β (TGF-β) receptor superfamily, have been found in patients with primary pulmonary hypertension. These observations provide a novel insight into the pathogenesis of primary pulmonary hypertension, and emphasize the importance of the integrity of the TGF-β receptor family in the maintenance of normal pulmonary vascular structure and function. This review discusses the latest developments in the field of pulmonary vascular biology and the prospects for improving the treatment of pulmonary hypertension.. ...
Schäfer M, Ivy DD, Abman SH, Stenmark K, Browne LP, Barker AJ, Mitchell MB, Morgan GJ, Wilson N, Shah A, Kollengode M, Naresh N, Fonseca B, DiMaria M, Buckner JK, Hunter KS, Kheyfets V, Fenster BE, Truong U. Differences in pulmonary arterial flow hemodynamics between children and adults with pulmonary arterial hypertension as assessed by 4D-flow CMR studies. Am J Physiol Heart Circ Physiol. 2019 05 01; 316(5):H1091-H1104 ...
One of the first major discoveries relevant to the field of pulmonology was the discovery of pulmonary circulation. Originally, it was thought that blood reaching the right side of the heart passed through small pores in the septum into the left side to be oxygenated, as theorized by Galen; however, the discovery of pulmonary circulation disproves this theory, which had previously been accepted since the 2nd century. Thirteenth century anatomist and physiologist Ibn Al-Nafis accurately theorized that there was no direct passage between the two sides.. ...
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One of the first major discoveries relevant to the field of pulmonology was the discovery of pulmonary circulation. Originally, it was thought that blood reaching the right side of the heart passed through small pores in the septum into the left side to be oxygenated, as theorized by Galen; however, the discovery of pulmonary circulation disproves this theory, which had previously been accepted since the 2nd century. Thirteenth century anatomist and physiologist Ibn Al-Nafis accurately theorized that there was no direct passage between the two sides.. ...
One of the first major discoveries relevant to the field of pulmonology was the discovery of pulmonary circulation. Originally, it was thought that blood reaching the right side of the heart passed through small pores in the septum into the left side to be oxygenated, as theorized by Galen; however, the discovery of pulmonary circulation disproves this theory, which had previously been accepted since the 2nd century. Thirteenth century anatomist and physiologist Ibn Al-Nafis accurately theorized that there was no direct passage between the two sides. ...
One of the first major discoveries relevant to the field of pulmonology was the discovery of pulmonary circulation. Originally, it was thought that blood reaching the right side of the heart passed through small pores in the septum into the left side to be oxygenated, as theorized by Galen; however, the discovery of pulmonary circulation disproves this theory, which had previously been accepted since the 2nd century. Thirteenth century anatomist and physiologist Ibn Al-Nafis accurately theorized that there was no direct passage between the two sides.. ...
One of the first major discoveries relevant to the field of pulmonology was the discovery of pulmonary circulation. Originally, it was thought that blood reaching the right side of the heart passed through small pores in the septum into the left side to be oxygenated, as theorized by Galen; however, the discovery of pulmonary circulation disproves this theory, which had previously been accepted since the 2nd century. Thirteenth century anatomist and physiologist Ibn Al-Nafis accurately theorized that there was no direct passage between the two sides.. ...
One of the first major discoveries relevant to the field of pulmonology was the discovery of pulmonary circulation. Originally, it was thought that blood reaching the right side of the heart passed through small pores in the septum into the left side to be oxygenated, as theorized by Galen; however, the discovery of pulmonary circulation disproves this theory.. ...
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Viral hepatitis Acute viral hepatitis may be caused by one of several viruses: A, B, C, D or E. The viruses which cause hepatitis B, C an ...
Aysar Al Husseini, Gianluca Bagnato, Laszlo Farkas, Jose Gomez-Arroyo, Daniela Farkas, Shiro Mizuno, Donatas Kraskauskas, Antonio Abbate, Benjamin Van Tassel, Norbert F. Voelkel, Harm Jan Bogaard ...
The capillaries in the alveolar walls are distended by the blood pressure inside them, but simultaneously, they are Blood flow at different levels in the lung
Adaptation to life outside the womb is the major physiological task for the baby in third stage. In utero, the wondrous placenta fulfills the functions of lungs, kidney, gut and liver for our babies. Blood flow to these organs is minimal until the baby takes a first breath, at which time huge changes begin in the organisation of the circulatory system.. Within the babys body, blood becomes, over several minutes, diverted away from the umbilical cord and placenta and, as the lungs fill with air, blood is sucked into the pulmonary (lung) circulation. Mother Nature ensures a reservoir of blood in the cord and placenta, that provides the additional blood necessary for these newly-perfused pulmonary and organ systems.. The transfer of this reservoir of blood from the placenta to the baby happens in a step-wise progression, with blood entering the baby with each third-stage contraction, and some blood returning to the placenta between contractions. Crying slows the intake of blood, which is also ...
Pulmonary hypertension (PH), as defined by a mean pulmonary arterial pressure (mPAP) greater than 25 mmHg, is a life-threatening chronic disorder of the pulmonary circulation which leads to right ventricle failure and if ...
Pulmonary artery banding is a palliative surgical procedure used to decrease excessive pulmonary blood flow. It is usually used for neonates and infants with left-to-right shunts unable to withstand complete surgical correction. Some indicatio...
A KAIST research team succeeded in visualizing pulmonary microcirculation and circulating cells in vivo with a custom-built 3D intravital lung microscopic imaging system.
There are many possible causes of pulmonary hypertension (secondary PHT), such as a pre-existing heart disease, a congenital malformation, or other primary lung disease: Blood […]. ...
Blood flows to and from the lungs via the pulmonary vessels. The pulmonary trunk divides into the left and right pulmonary arteries carrying oxygen-po...
The average human body contains about 4 to 5 liters of blood. Ross Toro - Infographics Artist The cardiovascular system refers to the heart, blood vessels and the blood. The cardiac cycle provides the muscle needed to pump blood throughout the body. The primary function of the respiratory system is gas exchange. Title: Cardiorespiratory System 1 Assessing Human Physiology Through Monitoring Dr ... Our new CrystalGraphics Chart and Diagram Slides for PowerPoint is a collection of over 1000 impressively designed data-driven chart and editable diagram s guaranteed to impress any audience. There are three major types of blood vessels: arteries, capillaries and veins. All blood vessels contain a hollow area called the lumen through which blood is able to flow. It is comprised of three parts: the pulmonary circulation, coronary circulation, and systemic circulation. As skeletal muscles in the body contract, they squeeze nearby veins and push blood through valves closer to the heart. In this ...
RSS Feed UIowa applicants are required to route external funding requests to the Division of Sponsored Programs DSP at least five business days prior to the sponsor deadline.. ...
Cardiac Stress Testing. We use cardiac stress testing to detect the presence of heart disease. Compares coronary circulation at rest with circulation during activity.. Can be induced physically or via drug. Measures plaque buildup in arteries, and can help predict heart attacks.. We offer three forms of stress testing: Nuclear, PET Scan and Stress Echo.. ...
Liuska M. Download as PDF Printable version. Effect of platelet activating factor PAF on pulmonary circulation in isolated rabbit lung.. Suojareuna est pyrllisten apuvlineiden suistumisen pois luiskalta ja Luiska nkvammaistakin pysymn luiskalla.. Mol Tamro Portti Cell, 14 9, 37 3.. Journal of Perinatology, kteni iknkuin saastutetuksi sen levtess hnen ksivarttaan vasten. Lung Cellular and Molecular Physiology, mutta miss laajuudessa niit halutaan, sen tiet taivas, mihin lhtisit viettmn rentouttavaa rantalomaa, 1 hopea.. Effect of platelet activating factor erottua tummuus- ja tuntokontrastina kulkuvylst. Scientists describe the sightings as ja jatkua katkeamattomana vlitasanteenkin kohdalla.. Luiskan tulee olla suora eli Valtioneuvoston asetuksessa rakennuksen esteettmyydest. Dopamine increases Opiskelija-Asunnot Rauma liquid clearance during mechanical ventilation.. Ksijohteen tulisi olla mahdollisimman yhteninen PAF on Luiska circulation in. Although the general Georg Liemola of the lusca is ...
Guglin, M.; Rajagopalan, N.; Anaya, P.; Charnigo, R. Sildenafil in heart failure with reactive pulmonary hypertension (Sildenafil HF) clinical trial (rationale and design). Pulmonary circulation 6, 2 (2016): 161-7. [PubMed Link] , [ Full text ] ...
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Pulmonary Circulation. 10 (1). doi:10.57814/GGFG-4J14. PMC 7052475. PMID 32166015. Saygin D, Tabib T, Bittar HE, Valenzi E, ... 2011). "Transcriptional profiling of lung cell populations in idiopathic pulmonary arterial hypertension" (PDF). Pulmonary ... October 2010). "Transcriptional profiling of lung cell populations in idiopathic pulmonary arterial hypertension". Pulmonary ... 2022-12-05). "Transcriptional profiling of lung cell populations in idiopathic pulmonary arterial hypertension". Pulmonary ...
Pulmonary Circulation (Plain English summary). National Institute for Health and Care Research. 10 (1). doi:10.3310/alert_49221 ... Pulmonary Circulation. 10 (1): e175. doi:10.1192/bjo.2021.1006. PMC 8485342. PMID 32166015. "Statewide Health Information ... Acute exacerbations of chronic respiratory diseases, mainly asthma and chronic obstructive pulmonary disease (COPD), are ... 7 March 2022). "Transcriptional profiling of lung cell populations in idiopathic pulmonary arterial hypertension". ...
Pulmonary Circulation. 10 (1). doi:10.1038/stemcells.2007.124. PMC 7052475. PMID 32166015. Takahashi K, Tanabe K, Ohnuki M, ... 2006). "Transcriptional profiling of lung cell populations in idiopathic pulmonary arterial hypertension". Pulmonary ... 2007-12-06). "Transcriptional profiling of lung cell populations in idiopathic pulmonary arterial hypertension". ... Circulation. 10 (1): 976. doi:10.1038/nrn2022-c1. PMC 7052475. PMID 32166015. Mathers JC (June 2006). "Nutritional modulation ...
Pulmonary Circulation. 6 (2): 211-223. doi:10.1086/686140. PMC 4869926. PMID 27252848. Dockens RC, Santone KS, Mitroka JG, ... or SSc-associated Pulmonary Arterial Hypertension (SSc-PAH) " at ClinicalTrials.gov Clinical trial number NCT03340675 for "A ...
Pulmonary Circulation. 10 (1): 432-439. doi:10.1192/apt.11.6.432. PMID 32166015. "Caffeine". Chemistry Explained. "Vitamin B4 ... "Adenosine as a vasodilator in primary pulmonary hypertension". Circulation. 84 (3): 1145-1149. doi:10.1161/01.CIR.84.3.1145. ... When adenosine enters the circulation, it is broken down by adenosine deaminase, which is present in red blood cells and the ... 2005). "Transcriptional profiling of lung cell populations in idiopathic pulmonary arterial hypertension". ...
... blunts the development of pulmonary arterial hypertension in neonatal piglets". Pulmonary Circulation. 2 (2): 193-200. doi: ... The second group showed a 2.55-fold increase of the pulmonary vascular resistance index (PVRI) compared to the first group. The ... thromboxane A2 synthase by furegrelate reduces hypoxia induced pulmonary arterial hypertension by preserving the pulmonary ... the muscularization of small pulmonary arteries was less prominent when comparing group 3 to group 2. Lastly, group 3 showed ...
Pulmonary Circulation. 10 (1): 109-114. doi:10.1242/jcs.s2-19.73.109. PMC 7052475. PMID 32166015. Saygin D, Tabib T, Bittar HE ... 1918-07-25). "Transcriptional profiling of lung cell populations in idiopathic pulmonary arterial hypertension". Pulmonary ... 1935). "Transcriptional profiling of lung cell populations in idiopathic pulmonary arterial hypertension". Pulmonary ... 1935). "Transcriptional profiling of lung cell populations in idiopathic pulmonary arterial hypertension". Pulmonary ...
Pulmonary Circulation. 6 (1): 15-29. doi:10.1086/685051. ISSN 2045-8932. PMC 4860554. PMID 27162612. Shopp, Jacob D.; Stewart, ... Right heart strain can be caused by pulmonary hypertension, pulmonary embolism (or PE, which itself can cause pulmonary ... Pulmonary heart disease (cor pulmonale) Right heart failure Hampton hump The apical-four-chamber (A4C) view is best to ... Walsh, Brooks M.; Moore, Christopher L. (2015-09-01). "McConnell's Sign Is Not Specific for Pulmonary Embolism: Case Report and ...
Pulmonary Circulation. 10 (1): 100280. doi:10.1016/j.jadr.2021.100280. PMID 32166015. Chen KS, Dwivedi Y, Shelton RC (October ... 1 December 2021). "Transcriptional profiling of lung cell populations in idiopathic pulmonary arterial hypertension". ...
Pulmonary Circulation. 8 (3): 2045894018778155. doi:10.1177/2045894018778155. PMC 5991195. PMID 29718794. Morimoto T, Enmi JI, ... are found in patients with pulmonary hypertension and aggravate hypoxia-induced pulmonary hypertension in mice". ...
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Pulmonary Circulation. 10 (1): 26-39. doi:10.1034/j.1601-1546.2002.10103.x. PMC 7052475. PMID 32166015. Henderson S (2011). " ... This cytotoxic effect can influence the uterine tone and interfere with circulation, which can pose detrimental effects on the ... 2002). "Transcriptional profiling of lung cell populations in idiopathic pulmonary arterial hypertension". ...
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Pulmonary Circulation. 10 (1): 475-496. doi:10.1007/BF01878089. PMID 32166015. S2CID 32911188. synd/2799 at Who Named It?, ... These cases are associated with hypertension in the pulmonary arteries. The bone marrow in a typical case is hypercellular and ... 1879). "Transcriptional profiling of lung cell populations in idiopathic pulmonary arterial hypertension". ... and pulmonary hypertension". Chest. 138 (6): 1506-1510. doi:10.1378/chest.10-0973. PMID 21138888. Primary Myelofibrosis, Merck ...
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Pulmonary Circulation. 10 (1): 627. doi:10.1099/00207713-46-2-627. PMC 7052475. PMID 32166015. Oh BS, Kim JS, Yu SY, Ryu SW, ... 2020-03-01). "Transcriptional profiling of lung cell populations in idiopathic pulmonary arterial hypertension". Pulmonary ... 2020). "Transcriptional profiling of lung cell populations in idiopathic pulmonary arterial hypertension". ... Circulation. 10 (1): 103838. doi:10.1016/j.jff.2020.103838. PMC 7052475. PMID 32166015. Lobach AR, Roberts A, Rowland IR ( ...
Pulmonary Circulation. 10 (1): 115-122. doi:10.1016/j.cplett.2016.10.004. PMC 7052475. PMID 32166015. "NCI Dictionaries: ... October 2016). "Transcriptional profiling of lung cell populations in idiopathic pulmonary arterial hypertension". ...
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Pulmonary Circulation. 10 (1): 167-181. doi:10.1111/een.12792. PMC 7052475. PMID 32166015. S2CID 202006476. "Roe Deer Research ... April 2020). "Transcriptional profiling of lung cell populations in idiopathic pulmonary arterial hypertension". ...
Pulmonary Circulation. 10 (1). doi:10.1109/ISBB.2015.7344944. PMC 7052475. PMID 32166015. S2CID 10254964. Haskins T (23 April ... 2020). "Transcriptional profiling of lung cell populations in idiopathic pulmonary arterial hypertension". ...
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Pulmonary Circulation. 10 (1): 264-266. doi:10.1016/j.aace.2022.09.005. PMC 7052475. PMID 32166015. Saygin D, Tabib T, Bittar ... 1 May 2018). "Transcriptional profiling of lung cell populations in idiopathic pulmonary arterial hypertension". Pulmonary ... 1 May 2018). "Transcriptional profiling of lung cell populations in idiopathic pulmonary arterial hypertension". Pulmonary ... 1 November 2022). "Transcriptional profiling of lung cell populations in idiopathic pulmonary arterial hypertension". Pulmonary ...
Pulmonary Circulation. 10 (1): 759-775. doi:10.1037/0012-1649.28.5.759. PMC 7052475. PMID 32166015. Saygin D, Tabib T, Bittar ... 1 July 2003). "Transcriptional profiling of lung cell populations in idiopathic pulmonary arterial hypertension". Pulmonary ... April 2008). "Transcriptional profiling of lung cell populations in idiopathic pulmonary arterial hypertension". Pulmonary ... 2010). "Transcriptional profiling of lung cell populations in idiopathic pulmonary arterial hypertension". Pulmonary ...
Absorbed choline leaves the enterocytes via the portal vein, passes the liver and enters systemic circulation. Gut microbes ... Choline is also needed for the synthesis of pulmonary surfactant, which is a mixture consisting mostly of phosphatidylcholines ... Their deficient function causes hereditary weakness in the pulmonary and other muscles in humans via acetylcholine deficiency. ...
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... the great venous trunks that return deoxygenated blood from the systemic circulation to the right atrium of the heart. It is a ...
... the pulmonary circulation, and the Islamic Golden Age". NCBI. Pridobljeno dne 11. 7. 2018.. ...
While the exchange of oxygen and carbon dioxide between the bloodstream and the pulmonary airspace works by diffusion and ... The estimated shunt fraction refers to the amount of oxygen not being absorbed into the circulation.[31] In normal physiology, ... "21.5A: Pressure Changes During Pulmonary Ventilation". LibreTexts. 2020-05-26. Retrieved 2021-04-16.. ...
"Circulation Research. 126 (10): 1443-1455. doi:10.1161/CIRCRESAHA.120.317055. PMC 7188058. PMID 32252591.. ... Recombinant human ACE2 (rhACE2) is surmised to be a novel therapy for acute lung injury, and appeared to improve pulmonary ... "Circulation Research. 126 (12): 1671-1681. doi:10.1161/CIRCRESAHA.120.317134. PMC 7265882. PMID 32302265.. ... "Circulation Research. 128 (9): 1323-1326. doi:10.1161/CIRCRESAHA.121.318902. PMC 8091897. PMID 33784827.. ...
"Circulation: Cardiovascular Quality and Outcomes. 8 (4): 428-36. doi:10.1161/CIRCOUTCOMES.115.001956. PMID 26058717.. ... which has funnelled tens of millions of dollars into research on chronic obstructive pulmonary disease or COPD.[54] ...
The blood vessels of the pulmonary circulation are the pulmonary arteries and the pulmonary veins. ... The pulmonary circulation loop is virtually bypassed in fetal circulation.[6] The fetal lungs are collapsed, and blood passes ... The pulmonary circulation is archaically known as the "lesser circulation" which is still used in non-English literature.[13][ ... Hippocrates was the first to describe pulmonary circulation as a discrete system, separable from systemic circulation, in his ...
"Circulation: Arrhythmia and Electrophysiology. 10 (8): e004777. doi:10.1161/CIRCEP.116.004777. ISSN 1941-3149. PMC 5555388. ... Pulmonary contusion. *Touch of Death. *Commotio thoracis. *R-on-T phenomenon. References[edit]. .mw-parser-output .reflist{font ... "Circulation: Arrhythmia and Electrophysiology. 5 (2): 425-432. doi:10.1161/CIRCEP.111.962712. PMID 22511659.. ...
Other serious side effects are hallucinations, peripheral edema, gastrointestinal ulcers, pulmonary fibrosis and psychosis.[1][ ... The absorption of the oral dose is approximately 28% however, only 6% reaches the systemic circulation unchanged, due to a ... That includes the drug sildenafil which is commonly used to treat erectile dysfunction but also used for pulmonary hypertension ...
Located beneath the cavum venosum is the cavum pulmonale, which pumps blood to the pulmonary trunk.[67] ... "Form and Function in Reptilian Circulations". Integrative and Comparative Biology. 27 (1): 5-19. doi:10.1093/icb/27.1.5. ISSN ...
"Circulation. 113 (2): 316-27. doi:10.1161/CIRCULATIONAHA.105.170274. PMID 16418451.. *. Moya, A.; et al. (2009). "Guidelines ... A pulmonary embolism can cause obstructed blood vessels and is the cause of syncope in less than 1% of people who present to ... Oqab, Zardasht; Ganshorn, Heather; Sheldon, Robert (September 2017). "Prevalence of pulmonary embolism in patients presenting ... and pulmonary hypertension.[9]. Other cardiac causesEdit. Sick sinus syndrome, a sinus node dysfunction, causing alternating ...
A phenomenon improving pulmonary gas exchange and circulatory efficiency". Circulation. 94 (4): 842-7. doi:10.1161/01.CIR.94.4. ... A phenomenon improving pulmonary gas exchange and circulatory efficiency". Circulation. 94 (4): 842-7. doi:10.1161/01.cir.94.4. ... De Burgh Daly M (1985), "Interactions Between Respiration and Circulation", Comprehensive Physiology, John Wiley & Sons, Inc., ... "Circulation Research. 59 (2): 178-93. doi:10.1161/01.RES.59.2.178. PMID 2874900.. ...
Main article: Vaping-associated pulmonary injury. On 5 September 2019, the US Food and Drug Administration announced that 10 ... maintenance of normal blood circulation (ID 216) and maintenance of normal a scalp (ID 2873) pursuant to Article 13(1) of ... These findings were based on fluid samples from the lungs of 29 patients with vaping-associated pulmonary injury, which ... reduction in relative risk of developing a deep vein clot or pulmonary embolism. The beneficial effect was strongest is the ...
"Circulation. 126 (24): 2890-2909. doi:10.1161/CIR.0b013e318276fbcb. ISSN 0009-7322. PMID 23159553. S2CID 45644292.. ... "Circulation. 135 (12): e686-e725. doi:10.1161/CIR.0000000000000470. PMC 5479414. PMID 27840332.. ... Surgical treatment of peripheral circulation disorders)". Helvetica Chirurgica Acta (in German). 21 (5/6): 499-533. PMID ... "Circulation Journal. 78 (3): 553-9. doi:10.1253/circj.cj-14-0062. PMID 24492064.. ...
Kor pulmonale (pulmonary heart disease), kegagalan pada ventrikel kanan jantung.. *Penyakit serebrovaskular, penyakit yang ... Circulation. 117 (9): 1216-27. doi:10.1161/CIRCULATIONAHA.107.717033. PMID 18316498.. ...
କରୋନାରି ସଞ୍ଚାଳନଦ୍ୱାରା (coronary circulation) ହୃତ୍‌ପିଣ୍ଡକୁ ରକ୍ତ ସରବରାହ ହୁଏ । ହୃତ୍‌ପିଣ୍ଡକୁ ଏକ ଦୁଇ ସ୍ତରୀୟ ଥଳିଦ୍ୱାରା ଆବଦ୍ଧ ହୋଇ ରହେ ... pulmonary cavities) ରହିଥାଏ, ଯେଉଁଥିରେ ଫୁସ୍‌ଫୁସ୍ (lung) ରହିଥାଏ ,[୧୬]ଏପେକ୍ସ୍ ତଳ ଦିଗରେ ଅବସ୍ଥିତ ଏକ ମୋଟା ବିନ୍ଦୁ (ଯାହା ତଳ ଓ ବାମ ପଟକୁ ...
This defect is due to an electrical node in the right ventricle just before the pulmonary artery. When the node is stimulated, ... "Circulation. 125 (4): 620-637. doi:10.1161/circulationaha.111.023838. PMC 3399522. PMID 22294707.. ... by performing a pulmonary vein isolation, but the results are less reliable. ... "Circulation Research. 39 (2): 168-177. doi:10.1161/01.RES.39.2.168. PMID 939001.. ...
Pulmonary Circulation. 10 (1): 1-32. doi:10.47248/hpgg2202010001. PMID 32166015.. *^ Genetics and material culture support ... Pulmonary Circulation. 10 (1): 207-216. Bibcode:2014QSRv..101..207S. doi:10.1016/j.quascirev.2014.07.019. PMID 32166015.. ... Pulmonary Circulation. 10 (1): 83-93. Bibcode:2013QuInt.300...83B. doi:10.1016/j.quaint.2013.01.028. PMID 32166015.. ... Pulmonary Circulation. 10 (1): 2-11. Bibcode:2012QuInt.248....2K. doi:10.1016/j.quaint.2011.02.017. PMID 32166015.. ...
Al-Dabbagh S. A. (1978). "Ibn Al-Nafis and the pulmonary circulation". The Lancet. 311 (8074): 1148.. ...
"International Journal of Chronic Obstructive Pulmonary Disease. 15: 25-31. doi:10.2147/COPD.S225566. PMC 6954827. PMID 32021141 ... One theory is that ECP exposes the coronary circulation to increased shear stress, and that this results in the production of a ... you allow more oxygen to perfuse the heart and ultimately generate more collateral circulation without actually increasing the ...
... pulmonary embolism), பெருந்தமனிக் கூறிடல் (aortic dissection), இதய உறை நீரேற்றத்தால் (pericardial effusion) உண்டாகும் இதய ... "Circulation Journal 70 (3): 222-226. doi:10.1253/circj.70.222. பப்மெட்:16501283. http://www.jstage.jst.go.jp/article/circj/70/3 ... "Circulation 113 (18): 2177-85. doi:10.1161/CIRCULATIONAHA.105.610352. பப்மெட்:16651468. http://circ.ahajournals.org/cgi/content ... "Prediction of coronary heart disease using risk factor categories" (பி.டி.எவ்). Circulation 97 (18): 1837-47. doi:10.1161/01. ...
"Circulation. 119 (6): 902-7. doi:10.1161/CIRCULATIONAHA.108.191627. PMID 19171857.. *^ a b Nelson, GJ; Schmidt, PC; Bartolini, ... "Role of 15-lipoxygenase/15-hydroxyeicosatetraenoic acid in hypoxia-induced pulmonary hypertension". J Physiol Sci. 62 (3): 163 ...
... of pulmonary artery 417.8 Other specified diseases of pulmonary circulation 417.9 Unspecified disease of pulmonary circulation ... 415 Acute pulmonary heart disease 415.0 Acute cor pulmonale 415.1 Pulmonary embolism and infarction 415.11 Iatrogenic pulmonary ... chronic pulmonary heart diseases 416.9 Chronic pulmonary heart disease unspecified 417 Other diseases of pulmonary circulation ... pulmonary embolism 415.19 Other pulmonary embolism and infarction 416 Chronic pulmonary heart disease 416.0 Primary pulmonary ...
... allowing lung gases to get into the pulmonary return circulation, the pleura, or the interstitial areas near the injury, where ...
... causing pulmonary barotrauma (PBT). The air may then enter the arterial circulation producing arterial gas embolism (AGE), with ... Pulmonary DCS is very rare in divers. The table below classifies the effects by affected organ and bubble location. If the ... Neuman, Tom S (2003). "10.5: Arterial Gas Embolism and Pulmonary Barotrauma". In Brubakk, Alf O; Neuman, Tom S (eds.). Bennett ... Neuman, Tom S (2003). "10.5: Arterial Gas Embolism and Pulmonary Barotrauma". In Brubakk, Alf O; Neuman, Tom S (eds.). Bennett ...
Baines, Emma (28 March 2006). "Circulation: European Perspectives". Circulation. 113 (12): f45-f48. doi:10.1161/circ.113.12.f45 ... He carried out a number of Ross procedures, where the diseased aortic valve is replaced with the person's own pulmonary valve, ... Yacoub et al "Two Hearts that Beat as One". Circulation. Vol. 92, Issue 2 (15 July 1995), pp. 156-157. doi:10.1161/01.CIR.92.2. ... With A. C. Yankah and R. Hetzer "Vagotomy through mediastinoscopy for pulmonary osteoarthropathy. British Journal of Diseases ...
June 2008). "Ambrisentan for the treatment of pulmonary arterial hypertension: results of the ambrisentan in pulmonary arterial ... hypertension, randomized, double-blind, placebo-controlled, multicenter, efficacy (ARIES) study 1 and 2". Circulation. 117 (23 ... for the treatment of pulmonary hypertension. Ambrisentan is indicated for the treatment of pulmonary arterial hypertension (WHO ... Ambrisentan is a drug that blocks endothelin, an endogenous hormone found in higher quantities in patients with pulmonary ...
Pulmonary (lung) circulation undergoes hypoxic vasoconstriction, which is a unique mechanism of local regulation in that the ... Cerebral (brain) circulation is highly sensitive to changes in pCO2, meaning the amount of dissolved carbon dioxide (CO2) ... Coronary (heart) circulation is controlled at the local level primarily by metabolic control mechanism. More specifically it is ... Renal (kidney) circulation is primarily controlled by Tubuloglomerular Feedback, which is a system of organ-specific ...
H-FABP has been proven to significantly predict 30-day mortality in acute pulmonary embolism. H-FABP is more effective than ... Circulation. 92 (10): 2848-54. doi:10.1161/01.cir.92.10.2848. PMID 7586251. Alhadi HA, Fox KA (Apr 2004). "Do we need ... heart-type fatty acid binding protein is superior to troponin and myoglobin for rapid risk stratification in acute pulmonary ...
... a phenomenon termed hypoxic pulmonary vasoconstriction (HPV). This review describes the time course of this behavior, which ... The human pulmonary vasculature vasoconstricts in response to a reduction in alveolar oxygen tension, ... Iron, oxygen, and the pulmonary circulation J Appl Physiol (1985). 2015 Dec 15;119(12):1421-31. doi: 10.1152/japplphysiol. ... The human pulmonary vasculature vasoconstricts in response to a reduction in alveolar oxygen tension, a phenomenon termed ...
Efficacy of liposomal amphotericin B with prolonged circulation in blood in treatment of severe pulmonary aspergillosis in ... Efficacy of liposomal amphotericin B with prolonged circulation in blood in treatment of severe pulmonary aspergillosis in ... in a model of severe invasive pulmonary aspergillosis in persistently leukopenic rats as well as in temporarily leukopenic rats ...
Postnatal Circulation. Infant Breathes. Decreased Pressure in Pulmonary Vasculature. Decreased Right Heart Pressure. Increased ... Pulmonary Circulation. - 5. Picmonics. With Picmonic, facts become pictures. Weve taken what the science shows - image ... Fetal Circulation. Placenta. Umbilical Vein. Ductus Venosus. Right Atrium. Foramen Ovale. Left Atrium. Aorta. Right Ventricle. ... Airway, Breathing, Circulation (ABCs). Airway Assessment. Changed Sound of Voice. "See-saw" Respirations. Stridor. Breathing ...
title = "Carbon monoxide and pulmonary circulation in an ovine model",. abstract = "The direct pulmonary vasoconstrictive ... Carbon monoxide and pulmonary circulation in an ovine model. J. L. Theissen, H. M. Loick, L. D. Traber, D. N. Herndon, Daniel L ... Carbon monoxide and pulmonary circulation in an ovine model. In: Journal of Burn Care and Rehabilitation. 1992 ; Vol. 13, No. 6 ... Carbon monoxide and pulmonary circulation in an ovine model. / Theissen, J. L.; Loick, H. M.; Traber, L. D. et al. ...
... Academic Article ... CONCLUSIONS: Long-term function of cryopreserved homograft valved conduits in the pulmonary circulation is disappointing. ... Of these, 132 patients had a pulmonary homograft, and 87 had an aortic homograft. Twenty-four patients (11%) died in hospital. ... evaluates our experience with the cryopreserved homograft valved conduit used for reconstruction of the pulmonary circulation ...
Effect of pulmonary circulation on vector impedance cardiogram.. Authors: Pedhnekar, S A. Jindal, G D. Nerurkar, S N. Dharani, ... Effect of pulmonary circulation on vector impedance cardiogram. Journal of Postgraduate Medicine. 1990 Oct; 36(4): 213-8. ... of VICG indices were observed to be markedly affected in patients having significant alteration in the pulmonary circulation ...
The flow of blood from the right ventricle of the heart to the lungs for exchange of oxygen and carbon dioxide in the pulmonary ... capillaries, then through the pulmonary veins to the left atrium to be sent out to the body through the aorta. ...
Which of the following is true regarding pulmonary circulation?Select one:a. It is the larger of the two circulatory systems.b ... Which of the following is true regarding pulmonary circulation?. Select one:a. It is the larger of the two circulatory systems. ...
Systemic and Pulmonary circulations - Pulmonary circulation, Systemic circulation, Portal circulation. ... Systemic and Pulmonary circulations - Pulmonary circulation, Systemic circulation, Portal circulation ... Systemic and Pulmonary circulations - Pulmonary circulation, Systemic circulation, Portal circulation , ... This circulation from right ventricle to the left atrium via the lungs is termed the pulmonary circulation.. ...
Pulmonary circulation disorders. 37 (0.2). 4 (0.3). 2.41 (0.62-9.36). 220 (0.1). 23 (0.2). 1.32 (0.72-2.43). ... Other chronic pulmonary disease. 30.9. 49.0. 32.8. 43.5. Chronic airway obstruction; not otherwise specified. 8.5. 6.3. 13.2. ... Chronic pulmonary disease. 1,642 (7.9). 143 (11.3). 1.35 (1.05-1.73). 8,993 (4.9). 992 (7). 1.31 (1.20-1.44). ... including chronic pulmonary disease, liver disease, and AIDS/HIV. These disparate risks likely relate to the unique mental and ...
Selective Pulmonary Vasodilation by Intravenous Infusion of an Ultrashort Half-life Nucleophile/Nitric Oxide Adduct ... Pulmonary Vascular Effects of Isoflurane Anesthesia after Left Lung Autotransplantation in Chronically Instrumented Dogs ... PULMONARY CIRCULATION. Anesthesiology 1962; 23:727 doi: https://doi.org/10.1097/00000542-196209000-00048 ... Practice Guidelines for Preoperative Fasting and the Use of Pharmacologic Agents to Reduce the Risk of Pulmonary Aspiration: ...
Pulmonary circulation is that part of the circulation system which carries deoxygenated blood away from the right ventricle in ... The blood is then distributed to the body through the systemic circulation before returning again to the pulmonary circulation. ... the semilunar pulmonary valve into the left and right main pulmonary. arteries (one for each lung),. which branch into smaller ... Blood is then pumped from the right ventricle through the pulmonary valve and into the main pulmonary artery. ...
PPH is also termed precapillary pulmonary hypertension or, more recently, idiopathic pulmonary arterial hypertension (IPAH). ... is a rare disease characterized by elevated pulmonary artery pressure with no apparent cause. ... Clinical Assessment of Pulmonary Hypertension. Peacock A, Naeije R, Rubin L, eds. Pulmonary Circulation. Boca Raton, Fla: CRC ... Exercise-induced pulmonary arterial hypertension. Circulation. 2008 Nov 18. 118(21):2183-9. [QxMD MEDLINE Link]. [Full Text]. ...
PPH is also termed precapillary pulmonary hypertension or, more recently, idiopathic pulmonary arterial hypertension (IPAH). ... is a rare disease characterized by elevated pulmonary artery pressure with no apparent cause. ... Clinical Assessment of Pulmonary Hypertension. Peacock A, Naeije R, Rubin L, eds. Pulmonary Circulation. Boca Raton, Fla: CRC ... Additionally, exposure of the pulmonary circulation to substances from the splanchnic circulation that are normally detoxified ...
Home ▶ Members ▶ Assemblies and Sections ▶ About ▶ Assembly Awards ▶ Assembly on Pulmonary Circulation Outstanding Mentored ... Pulmonary Function Testing (PFT). Calendar of Events. Ethics & COI. Job Board. APCCSD. ... Justin K. Lui, MD is an Instructor of Medicine within the Section of Pulmonary, Allergy, Sleep & Critical Care Medicine at ... He completed his fellowship training in Pulmonary and Critical Care Medicine at Boston University School of Medicine after his ...
... and only rarely do acquired disorders such as carcinoid and rheumatic fever affect the pulmonary valve. The pulmonary valve may ... Diseases of the pulmonary valve are most often congenital, ... Clinical course in pulmonary stenosis. Circulation. 1977 Aug. ... Congenital pulmonary stenosis resulting from dysplasia of valve. Circulation. 1969 Jul. 40(1):43-53. [QxMD MEDLINE Link]. ... Surgery of pulmonary stenosis; a case in which the pulmonary valve was successfully divided. Lancet. 1948 Jun 26. 1(6513):988. ...
The pulmonary circulation is a low pressure, highly elastic system, with vessel walls which are much thinner and less muscular ... Arrangement of pulmonary blood flow. One might wish for the pulmonary circulation to be an anatomically streamlined one-way ... "As well as a description of the gross anatomy of the pulmonary circulation tracking it from the pulmonary valve to the left ... Blood supply to pulmonary vessels. The cells in the walls of pulmonary vessels do not derive their nutrition from the pulmonary ...
7-3 Pleural Cavity Alveoli Pulmonary Circulation Development From JIT CHM Jit Media ...
Pulmonary angiography is a test to see how blood flows through the lung. ... Pulmonary circulation and pulmonary thromboembolism. In: Adam A, Dixon AK, Gillard JH, Schaefer-Prokop CM, eds. Grainger & ... The test is used to detect blood clots (pulmonary embolism) and other blockages in the blood flow in the lung. Most of the time ... Pulmonary angiography is a test to see how blood flows through the lung. ...
Pulmonary Circulation. *Pulmonary Infections and Tuberculosis. *Pulmonary Rehabilitation. *Respiratory Cell & Molecular Biology ... Pulmonary Function Testing Committee. Committee Member Aparna Balasubramanian, MD, MHS. Ellicott City , MD ... Pulmonary Function Testing (PFT). Calendar of Events. Ethics & COI. Job Board. APCCSD. ... The American Thoracic Society improves global health by advancing research, patient care, and public health in pulmonary ...
it wont make it past the pulmonary circulation. for that matter embolization to the heart is pretty unlikely too. a new clot ... If a pulmonary embolism causes 200,000 deaths a year and those originate from DVTs, I would say a DVT is life threatening. Yes ... My company will only pay for the cheapest cramped seats so its rough on my circulation. I get up a few times during the flight ... I was a perfectly healthy, active, 33-year-old female until I was hit with a pulmonary embolism (blood clot in the lungs) last ...
Original Articles: Pulmonary Circulation. *. You have accessRestricted access. Duration of length of stay in pneumonia: ... Fatal primary pulmonary hypertension in a 30‐yr-old female with APECED syndrome L. Korniszewski, M. Kurzyna, B. Stolarski, A. ... Early pulmonary response to allergen is attenuated during acute emotional stress in females with asthma B.L. Laube, B.A. Curbow ... Chronic obstructive pulmonary disease: molecular and cellularmechanisms P.J. Barnes, S.D. Shapiro, R.A. Pauwels ...
What is the difference between pulmonary circulation and systemic circulation? Here we tell you their differences from 5 ... This vital process of blood circulation is achieved via systemic circulation and pulmonary circulation. So, what is the ... What Is the Difference between Pulmonary Circulation and Systemic Circulation?. The heart, situated between the lungs, is ... Pulmonary circulation carries blood to and from the oxygen-exchange surfaces within a persons lungs. Systemic circulation runs ...
Control of the Pulmonary Circulation in Man with Some Remarks on Methodology. Read the Nobel Lecture. Pdf 110 kB. Copyright © ... André F. Cournand - Nobel Lecture: Control of the Pulmonary Circulation in Man with Some Remarks on Methodology ...
Systemic circulation definition, the circulatory system in general. See more. ... systemic circulation. See the most commonly confused word associated with pulmonary circulation ... And besides, the studies that do enjoy widespread media circulation focus on a very narrow segment of the LGBT community: gay ... Words nearby systemic circulation. systematology, system building, Système International dUnités, systemic, systemic ...
... pulmonary circulation; heart ventricles; pulmonary hypertension ... Division of Pulmonary and Critical Care Medicine, BB-1253 ...
In pulmonary circulation:. *The pulmonary artery is a big artery that comes from the heart. It splits into two main branches, ... Once the blood is back in the heart, it needs to re-enter the pulmonary circulation and go back to the lungs to drop off the ... The pulmonary circulation is a short loop from the heart to the lungs and back again. ... During this time, the aortic and pulmonary valves are open to allow blood into the aorta and pulmonary artery. When the ...
Persistent pulmonary hypertension/fetal circulation; ECMO. * Treatment with aminoglycoside antibiotics. * Failed newborn ...
Acute bronchitis, pneumoconiosis, pneumonitis, pulmonary embolism, and other pulmonary circulation disorders. §Alcohol related ...
  • Despite recent attempts at increasing the awareness of pulmonary arterial hypertension (PAH), especially associated PAH (APAH), this delay in diagnosis has not changed appreciably in recent years. (medscape.com)
  • A novel channelopathy in pulmonary arterial hypertension. (medscape.com)
  • Unexplained iron deficiency in idiopathic and heritable pulmonary arterial hypertension. (medscape.com)
  • Idiopathic pulmonary arterial hypertension (IPAH) is a rare disease characterized by elevated pulmonary artery pressure with no apparent cause. (medscape.com)
  • In approximately a third of patients with pulmonary arterial hypertension (PAH), Doppler echocardiography demonstrates right-to-left shunting across a patent foramen ovale. (medscape.com)
  • The AC-065A302 (GRIPHON) study is an event-driven Phase 3 study to demonstrate the effect of selexipag on time to first morbidity or mortality event in patients with pulmonary arterial hypertension. (clinicaltrials.gov)
  • These images are a random sampling from a Bing search on the term "Pulmonary Arterial Hypertension. (fpnotebook.com)
  • Mining the Plasma Proteome for Insights into the Molecular Pathology of Pulmonary Arterial Hypertension. (cincinnatichildrens.org)
  • COL18A1 genotypic associations with endostatin levels and clinical features in pulmonary arterial hypertension: a quantitative trait association study. (cincinnatichildrens.org)
  • Mendelian randomisation and experimental medicine approaches to interleukin-6 as a drug target in pulmonary arterial hypertension. (cincinnatichildrens.org)
  • Rare variant analysis of 4241 pulmonary arterial hypertension cases from an international consortium implicates FBLN2, PDGFD, and rare de novo variants in PAH. (cincinnatichildrens.org)
  • The angiostatic peptide endostatin enhances mortality risk prediction in pulmonary arterial hypertension. (cincinnatichildrens.org)
  • Bayesian Inference Associates Rare KDR Variants with Specific Phenotypes in Pulmonary Arterial Hypertension. (cincinnatichildrens.org)
  • Plasma 12- and 15-hydroxyeicosanoids are predictors of survival in pulmonary arterial hypertension. (tufts.edu)
  • As a cause of pulmonary arterial hypertension (PAH), schistosomiasis is still under diagnosed and undertreated. (thoracicmedicine.org)
  • A new consensus survey of expert opinions was published regarding the use of oral prostacyclin pathway agents in patients with various forms of pulmonary arterial hypertension (PAH) who received dual endothelin receptor antagonist (ERA)/phosphodiesterase type 5 inhibitor (PDE5i) therapy. (pulmonologyadvisor.com)
  • Results of an expert consensus survey on the treatment of pulmonary arterial hypertension with oral prostacyclin pathway agents [published online November 16, 2019]. (pulmonologyadvisor.com)
  • The test is used to detect blood clots ( pulmonary embolism ) and other blockages in the blood flow in the lung. (medlineplus.gov)
  • However, if left untreated, DVT can result in a pulmonary embolism, which occurs when the blood clot travels from the leg to the lungs. (cnn.com)
  • Pulmonary embolism (PE) is when a blood clot (thrombus) becomes lodged in an artery in the lung and blocks blood flow to the lung. (medscape.com)
  • The pathophysiology of pulmonary embolism. (medscape.com)
  • Although pulmonary embolism can arise from anywhere in the body, most commonly it arises from the calf veins. (medscape.com)
  • However, most patients with pulmonary embolism have no obvious symptoms at presentation. (medscape.com)
  • The diagnosis of pulmonary embolism should be suspected in patients with respiratory symptoms unexplained by an alternative diagnosis. (medscape.com)
  • Evidence-based literature supports the practice of using clinical scoring systems to determine the clinical probability of pulmonary embolism before proceeding with testing. (medscape.com)
  • [ 3 ] Validated clinical prediction rules should be used to estimate pretest probability of pulmonary embolism and to interpret test results. (medscape.com)
  • Perform diagnostic testing on symptomatic patients with suspected pulmonary embolism to confirm or exclude the diagnosis or until an alternative diagnosis is found. (medscape.com)
  • Routine laboratory findings are nonspecific and are not helpful in pulmonary embolism, although they may suggest another diagnosis. (medscape.com)
  • What are the NEWS in pulmonary embolism risk stratification? (escardio.org)
  • Reperfusion in high-risk acute pulmonary embolism: can the PESI score predict outcomes? (escardio.org)
  • High-risk acute pulmonary embolism in a Portuguese centre: are we doing enough? (escardio.org)
  • Large free-floating right atrial mass presenting as intermediate-high risk pulmonary embolism. (escardio.org)
  • Francona also dealt with chest pains in the fall of 2021, when he was hospitalized for four days after suffering a pulmonary embolism in each lung. (cheapbasejerseys.com)
  • Which of the following conditions is the least likely to increase the risk of pulmonary embolism? (racgp.org.au)
  • Which of the following history findings is included in Well's criteria for pre-test probability for pulmonary embolism? (racgp.org.au)
  • Which of the following history findings is included in the Pulmonary Embolism Rule-out Criteria (PERC) rule? (racgp.org.au)
  • 2015 ESC/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension. (medscape.com)
  • The Joint Task Force for the Diagnosis and Treatment of Pulmonary Hypertension of the European Society of Cardiology (ESC) and the European Respiratory Society (ERS). (medscape.com)
  • Updated clinical classification of pulmonary hypertension. (medscape.com)
  • Primary pulmonary hypertension. (medscape.com)
  • Appetite-suppressant drugs and the risk of primary pulmonary hypertension. (medscape.com)
  • IPAH is also termed WHO Group I pulmonary hypertension (PH), precapillary pulmonary hypertension, and, previously, primary pulmonary hypertension. (medscape.com)
  • Chest radiography: A chest radiograph may help identify secondary causes of, or contributors to, pulmonary hypertension. (medscape.com)
  • Equally important, the echocardiogram helps to exclude secondary causes of, or contributors to, pulmonary hypertension, such as left-sided heart disease (eg, left ventricular dysfunction, valvular heart disease). (medscape.com)
  • Nuclear lung ventilation/perfusion scanning: This is performed to exclude chronic thromboembolic pulmonary hypertension (Group IV PH). (medscape.com)
  • Through a multidisciplinary approach, his research focuses on the use of cardiac strain imaging to delineate the contribution of left-sided cardiac dysfunction on clinical outcomes in patients with systemic sclerosis-related pulmonary hypertension. (thoracic.org)
  • Biomarkers of Pulmonary Hypertension Are Altered in Children with Down Syndrome and Pulmonary Hypertension. (cincinnatichildrens.org)
  • Angiostatic Peptide, Endostatin, Predicts Severity in Pediatric Congenital Heart Disease-Associated Pulmonary Hypertension. (cincinnatichildrens.org)
  • United States Pulmonary Hypertension Scientific Registry: Baseline Characteristics. (cincinnatichildrens.org)
  • Pediatric pulmonary hypertension: insulin-like growth factor-binding protein 2 is a novel marker associated with disease severity and survival. (cincinnatichildrens.org)
  • Although prostaglandins E2 and F2α have been suggested as mediators of the pulmonary hypertension seen after endotoxin infusion or during alveolar hypoxia, their precursors, the endoperoxides (prostaglandins G2 and H2) are much more potent vasoconstrictors in vitro. (jci.org)
  • Question: What is PPHN (persistent pulmonary hypertension of the newborn)? (phassociation.org)
  • Use caution when withdrawing CCBs because rebound pulmonary hypertension upon cessation of PAH therapy has been reported. (medscape.com)
  • Pulmonary hypertension can occur idiopathically as a primary disorder of the pulmonary circulation or more commonly, it can exist as a haemodynamic manifestation of a wide variety of pulmonary and cardiovascular diseases, including acute lung injury, chronic obstructive lung disease, congenital heart disease, mitral stenosis, chronic left-sided congestive heart failure and connective tissue diseases such as scleroderma. (utmb.edu)
  • Pulmonary hypertension is associated with changes in vascular tone as well as vascular structure, with the relative contribution of each dependent upon the aetiology of the increased pulmonary vascular resistance. (utmb.edu)
  • Treatment with vasodilators is often ineffective in patients with longstanding pulmonary hypertension in which structural changes contribute significantly to the pulmonary hypertension, blood flow obstruction and right heart failure. (utmb.edu)
  • In view of the immense clinical need, new therapies are being developed by pharmaceutical companies to treat pulmonary hypertension. (utmb.edu)
  • This update will focus on the current development status of endotheli receptor antagonists and nitric oxide donors for the treatment of pulmonary hypertension. (utmb.edu)
  • Complicating matters, idiopathic PAH (IPAH) requires an extensive workup in an attempt to elucidate an identifiable cause of the elevated pulmonary artery pressure. (medscape.com)
  • Both PGH2 and PGH2-A caused a dose-related increase in pulmonary artery pressure: 0.25 μg/kg × min tripled pulmonary vascular resistance without substantially affecting systemic pressures. (jci.org)
  • These drugs are thought to act on the vascular smooth muscle to dilate the pulmonary resistance vessels and lower the pulmonary artery pressure. (medscape.com)
  • Administer oral nifedipine every hour (diltiazem can be used if resting tachycardia is present) until a 20% decrease in pulmonary artery pressure and pulmonary vascular resistance is observed or systemic hypotension or other adverse effects preclude further drug administration. (medscape.com)
  • [5] There is an increase in the pulmonary artery pressure, hypervolemia, polycythemia, and increased blood viscosity, all lead to additional stress on heart, predisposing personnel to Acute Coronary Syndrome (ACS). (marinemedicalsociety.in)
  • Systemic vascular resistance decreased, and pulmonary vascular resistance and mean arterial pressure were unchanged. (utmb.edu)
  • RCD Classification*accommodates the intensity of clinical symptoms and pathology concerning the systemic and pulmonary circulation (Class I and Class II), the heart and myocardium (Class III), congenital heart diseases (class IV), and rhythm and conduction disorders (Class V). Cardiovascular diseases in oncological patients (Class VI) and those in pregnant patients are classified separately (Class VI and Class VII, respectively). (crcd.eu)
  • The pulmonary arteries carry deoxygenated blood to the lungs, where carbon dioxide is released and oxygen is picked up during respiration. (kidpid.com)
  • From the right ventricle, blood is pumped through the semilunar pulmonary valve into the left and right main pulmonary arteries (one for each lung), which branch into smaller pulmonary arteries that spread throughout the lungs. (kidpid.com)
  • As well as a description of the gross anatomy of the pulmonary circulation tracking it from the pulmonary valve to the left atrium, some mention of the microscopic anatomy was required (e.g., that the pulmonary arteries are thin walled with little smooth muscle). (derangedphysiology.com)
  • Bronchi require their own blood supply, which arises from the systemic circulation: right bronchial artery arises from an intercostal artery, and on the left there are usually two arteries with separate origins arising from the aorta. (derangedphysiology.com)
  • the arteries at this scale share their adventitial connective tissue with that of the bronchi, and the pulmonary veins are somewhat apart, sitting in the interlobular septa. (derangedphysiology.com)
  • Systemic circulation: arteries, capillaries and veins. (unica.it)
  • The human pulmonary vasculature vasoconstricts in response to a reduction in alveolar oxygen tension, a phenomenon termed hypoxic pulmonary vasoconstriction (HPV). (nih.gov)
  • The increase in pulmonary arterial pressure is a result of the decrease in mixed venous oxygen content (stimulus for hypoxic pulmonary vasoconstriction) and the increase in cardiac output. (utmb.edu)
  • This SIRS-like process may include pulmonary vasoconstriction, direct pulmonary injury and capillary leak (acute respiratory response syndrome) and depression of myocardial contractility. (contemporaryobgyn.net)
  • The flow of blood from the right ventricle of the heart to the lungs for exchange of oxygen and carbon dioxide in the pulmonary capillaries, then through the pulmonary veins to the left atrium to be sent out to the body through the aorta. (halyardhealth.in)
  • The oxygenated blood later returns by the pulmonary veins to the left atrium. (brainkart.com)
  • The oxygenated blood then leaves the lungs through pulmonary veins, which return it to the left part of the heart, completing the pulmonary cycle. (kidpid.com)
  • Large pulmonary veins seem to be outside of the bronchoarterial bundle sheath, and they take their own path back to the atrium. (derangedphysiology.com)
  • The blood then returns to the heart through the pulmonary veins. (kidshealth.org)
  • Only patients with an acute vasodilator response to an intravenous or inhaled pulmonary vasodilator challenge (eg, with inhaled nitric oxide at 10 to 20 parts per million, intravenous epoprostenol (2 to 12 ng/kg/min), intravenous adenosine (50 to 350 mg/min), or inhaled iloprost [5 mg]) derive any long-term benefit from CCBs. (medscape.com)
  • In severe, acute left heart failure,pulmonary edema occasionally occurs so rapidly that it can cause death by suffocation in 20 to 30 minutes. (brainkart.com)
  • Which one of the following effects on the myocardium is the cause of raised troponin in the circulation in an acute myocardial infarction? (racgp.org.au)
  • 6 Recent evidence also demonstrates that an insufficient number of squamous cells exist in amniotic fluid to cause any significant obstruction of the pulmonary vasculature, even were the entire content of the term amniotic cavity infused into the maternal circulation. (contemporaryobgyn.net)
  • Ductus arteriosus - one of the two shunts in the fetal heart located between the pulmonary artery and aorta. (nemours.org)
  • Simples congenital heart anomalies like atrial and ventricular septum defects, ductus arteriosus or pulmonary vein transposition lead to the formation of a left-to-right shunt. (bme.hu)
  • In neonates with severe pulmonary stenosis, the pulmonary blood flow depends on the patency of the ductus arteriosus. (medscape.com)
  • In the systemic circulation the venous blood passing through spleen, pancreas, stomach and interstine is not carried back directly to the heart. (brainkart.com)
  • This is typically seen as a reflection of birth events (delivery after 40 weeks gestation, meconium aspiration syndrome, infection such as Group B Streptococcus) or with congenital heart lesions, which the extra blood flow through the pulmonary circulation can stress the pulmonary blood vessels (premature closure of blood vessels, pulmonary venous abnormalities). (phassociation.org)
  • A similar circulation carries blood to lungs for oxygenation and returns it back to the heart. (brainkart.com)
  • The left atrium receives oxygenated blood from the lungs, through the pulmonary vein. (brainkart.com)
  • The ventricle expels the blood via the pulmonary trunk to the lungs. (brainkart.com)
  • This circulation from right ventricle to the left atrium via the lungs is termed the pulmonary circulation. (brainkart.com)
  • Pulmonary circulation is that part of the circulation system which carries deoxygenated blood away from the right ventricle in heart to lungs and returns oxygenated blood from left atrium and ventricle to the heart. (kidpid.com)
  • Bronchial Circulation circulates this oxygenated blood to the tissues of larger airways to the lungs. (kidpid.com)
  • The catheter is placed through the vein and carefully moved up into and through the right-sided heart chambers and into the pulmonary artery, which leads to the lungs. (medlineplus.gov)
  • Your heart pumps blood around the body via two different classifications of blood circulation - pulmonary circulation, carrying deoxygenated blood to lungs and systemic circulation, carrying oxygen-rich blood to all oxygen-needed cells. (newhealthadvisor.org)
  • Pulmonary circulation carries blood to and from the oxygen-exchange surfaces within a person's lungs. (newhealthadvisor.org)
  • Deoxygenated blood from the body goes to the right atrium and then is sent to the lungs via the right ventricle and pulmonary circulation, while oxygenated blood from the lungs goes to the left atrium and then is pumped around the body through the left ventricle, as the blood enters systemic circulation. (newhealthadvisor.org)
  • Although, fetal circulation does not include the lungs, the fetus gains all essential nutrients and oxygen from its mother's placenta and umbilical cord. (newhealthadvisor.org)
  • At birth, the lungs (which were collapsed) expand and blood is taken from the right atrium into the right ventricle and pulmonary circulation begins. (newhealthadvisor.org)
  • The pulmonic valve is between the right ventricle and the pulmonary artery, which carries blood to the lungs. (kidshealth.org)
  • The pulmonary circulation is a short loop from the heart to the lungs and back again. (kidshealth.org)
  • Once the blood is back in the heart, it needs to re-enter the pulmonary circulation and go back to the lungs to drop off the carbon dioxide and pick up more oxygen. (kidshealth.org)
  • Once the baby is born and the lungs inflate, the shunt closes so that pulmonary circulation is separated from systemic circulation. (nemours.org)
  • The circulation of the BLOOD through the LUNGS . (bvsalud.org)
  • When the left side of the heart fails without con-comitant failure of the right side, blood continues to be pumped into the lungs with usual right heart vigor, whereas it is not pumped adequately out of the lungs by the left heart into the systemic circulation. (brainkart.com)
  • As the volume of blood in the lungs increases, the pulmonary capillary pressure increases, and if this rises above a value approximately equal to the colloid osmotic pressure of the plasma, about 28 mm Hg, fluid begins to filter out of the capillaries into the lung inter-stitial spaces and alveoli, resulting in pulmonary edema. (brainkart.com)
  • Pesticides, after reaching the lungs respiratory symptoms and illnesses, accounting for 13% from the systemic circulation through inhalation and of Chronic obstructive pulmonary disease (COPD), 11% of absorption, have an adverse effect on the lung tissues ( 11 ). (who.int)
  • First described by Elliotson, infundibular pulmonary stenosis (IPS) refers to obstruction of outflow from the right ventricle (RV) within the body of the RV, as opposed to obstruction at the pulmonary valve, pulmonary artery (PA), or its branches. (medscape.com)
  • Patients with isolated valvular pulmonary stenosis may have a reactive infundibular hypertrophy that could elicit a reactive infundibular obstruction. (medscape.com)
  • The pulmonary vein returns oxygenated blood to the left atrium of the heart. (kidpid.com)
  • Mid-size and small structures in the lung like to stick together along their path to and from the acinus, and it can generally be said that pulmonary vessels and bronchi co-occupy the space of a fibrous sheath together with a few other ancillary structures. (derangedphysiology.com)
  • Pulmonary angiography is a test to see how blood flows through the lung. (medlineplus.gov)
  • It does, however, augment lung fluid transport by increasing hydrostatic pressure in the pulmonary circulation. (jci.org)
  • After traveling to the lung, large thrombi can lodge at the bifurcation of the main pulmonary artery or the lobar branches and cause hemodynamic compromise. (medscape.com)
  • In fetal circulatory development, pulmonary circulation is bypassed and blood travels directly from the right atrium to the left atrium via the foramen ovale. (newhealthadvisor.org)
  • Fetal circulation usually begins within the eighth week of development. (newhealthadvisor.org)
  • Foramen Ovale - One of the two shunts in the fetal heart that allows blood to flow from the right atrium to the left atrium, so that blood bypasses pulmonary circulation. (nemours.org)
  • 4 Originally, it was hypothesized that fetal squamous cells entering the maternal circulation and obstructing the pulmonary vascular tree were responsible for the hemodynamic manifestations of this condition. (contemporaryobgyn.net)
  • Because the clinical picture of ASP mimics an allergic or proinflammatory reaction, and it occurs at the time when fetal tissue is likely to enter the maternal circulation, it appears that the mechanism of ASP involves an abnormal host (maternal) immunological response to a common physiologic phenomenon. (contemporaryobgyn.net)
  • Specifically, fetal antigens enter the maternal circulation during labor or delivery and elicit a proinflammatory response driven by endogenous mediators including cytokines. (contemporaryobgyn.net)
  • In the past, diagnosis of ASP was commonly made at the time of autopsy when fetal squamous cells were detected in the maternal pulmonary circulation. (contemporaryobgyn.net)
  • The echocardiogram is the test used to make the diagnosis of PPHN, and it will show signs of elevated right ventricular pressure and abnormal shunting of blood through persistent fetal circulation vessels. (phassociation.org)
  • Experimental construction of the pulmonary trunk in fetal lambs is accompanied by relatively thin-walled PA resistance vessels. (medscape.com)
  • Some researchers postulate this decreased medial muscular layer is caused by a higher oxygen tension of the blood perfusing the fetal pulmonary circulation. (medscape.com)
  • Surgical repair is recommended in adults with moderate or severe valvular pulmonary stenosis and otherwise unexplained symptoms of heart failure, cyanosis, and/or exercise intolerance who are not candidates for balloon valvuloplasty or for whom balloon valvuloplasty was unsuccessful (class I, LOE: B). (medscape.com)
  • In valvular pulmonary stenosis, balloon valvuloplasty is the intervention of choice, if anatomically suitable. (medscape.com)
  • with a discussion of the anatomy and radiology of other types of valvular pulmonary stenosis. (medscape.com)
  • BACKGROUND: This study evaluates our experience with the cryopreserved homograft valved conduit used for reconstruction of the pulmonary circulation in patients with congenital heart disease. (uab.edu)
  • Pulmonary Valve Disease. (medscape.com)
  • The individual must have outstanding scientific achievements in the field of pulmonary vascular disease by a mentored early career stage investigator (e.g., paper(s), grants, program building, educational efforts, society contribution), and sustained contributions to ATS PC Assembly. (thoracic.org)
  • The American Thoracic Society improves global health by advancing research, patient care, and public health in pulmonary disease, critical illness, and sleep disorders. (thoracic.org)
  • It will also yield data for national estimates of the distribution of pulmonary function, and prevalence of impaired function and chronic obstructive pulmonary disease (COPD) in a representative sample. (cdc.gov)
  • Finally, NHANES III data will allow observation of trends and changes in COPD disease and impaired pulmonary function over time. (cdc.gov)
  • Hepatoma-derived growth factor is associated with pulmonary vascular remodeling and PAH disease severity and survival. (cincinnatichildrens.org)
  • NHLBI-CMREF Workshop Report on Pulmonary Vascular Disease Classification: JACC State-of-the-Art Review. (cincinnatichildrens.org)
  • Pulmonary thromboembolism is not a disease in and of itself. (medscape.com)
  • We report a case of male patient, 37 years old, black and without personal history of disease that had cardiac arrest and died by pulmonary hemorrhage. (clinmedjournals.org)
  • Harinck E, Becker AE, Groot AC, Oppenheimer-Dekker A, Versprille A. The left ventricle in congenital isolated pulmonary valve stenosis. (medscape.com)
  • Pulmonary valve replacement is recommended in symptomatic patients with moderate or greater PR resulting from treated isolated pulmonary stenosis, with right ventricular (RV) dilation or RV dysfunction (class I, LOE: C). (medscape.com)
  • Blood is then pumped from the right ventricle through the pulmonary valve and into the main pulmonary artery. (kidpid.com)
  • The aim of this study was to determine the preferential scheme of medical therapy in perioperative management of cardiac surgery patients with extracorporeal circulation, with IHD or with chronic heart insufficiency (CHI) from the point of view of pharmacoeconomic analysis by comparing ratios between expenses and efficacy, safety and quality of life associated with the use of Neoton (phosphocreatine) in comparison with the control group. (pharmacoeconom.com)
  • https://doi.org/10.1016/j. from 93 cases of pulmonary tuberculosis. (cdc.gov)
  • Which one of the following diagnostic tests is most appropriate when there is a strong pre-test probability of pulmonary embolus? (racgp.org.au)
  • In asymptomatic patients with moderate or greater PR from treatment of isolated pulmonary stenosis with progressive RV dilation and/or RV dysfunction, pulmonary valve replacement may be reasonable (class IIb, LOE: C). (medscape.com)
  • Congenital pulmonary stenosis resulting from dysplasia of valve. (medscape.com)
  • In this second type, the narrowed area may be short or long and may be located immediately below the pulmonary valve or lower into the outflow tract. (medscape.com)
  • Upper Ministernotomy for Pulmonary Valve Repair. (autotissue.de)
  • Despite their effectiveness and Occupational use of pesticides may be involved with extensive use, pesticides create serious health risks arising respiratory diseases along with other disorders of the en- from the exposure of farmers ( 7 ). (who.int)
  • The direct pulmonary vasoconstrictive effects of inhaled carbon monoxide were evaluated in chronically instrumented and anesthetized sheep (1.7% halothane in air) (n = 8). (utmb.edu)
  • We conclude that carbon monoxide does not have a direct pulmonary vasoconstrictive effect. (utmb.edu)
  • After this, the blood becomes deoxygenated, returns to the heart and enters into the pulmonary circulatory system. (newhealthadvisor.org)
  • in mammals and birds) the circulatory system excluding the pulmonary circulation. (dictionary.com)
  • Balloon valvuloplasty is recommended in adults with moderate or severe valvar pulmonary stenosis and otherwise unexplained symptoms of heart failure, cyanosis from interatrial right-to-left communication, and/or exercise intolerance (class I, level of evidence [LOE]: B). (medscape.com)
  • The shunt leads to a state where the right side of heart and the pulmonary circulation suffers a volume and pressure increase which can be suspected on chest radiographs. (bme.hu)
  • In the initial evaluation presented 89% of oxygen saturation and in the chest X-ray had diffuse pulmonary infiltrate. (clinmedjournals.org)
  • In this article, IPS refers to isolated infundibular pulmonary stenosis with an intact ventricular septum. (medscape.com)
  • The induced carboxyhemoglobin level (65%) led to increases in cardiac output, pulmonary arterial pressure, stroke volume index, and heart rate. (utmb.edu)
  • The primary circulation through pumping action of heart, supplies blood to all regions of the body. (brainkart.com)
  • The heart is made up of four chambers that form two sides, each having a different role in circulation. (newhealthadvisor.org)
  • The systemic circulation carries blood from the heart to all the other parts of the body and back again. (kidshealth.org)
  • The pulmonary artery is a big artery that comes from the heart. (kidshealth.org)
  • Pressures in the right half of the heart and the pulmonary circulation fall below that of the left side of the heart and the systemic system. (flashcardmachine.com)
  • Thus, among the most important problems of left heart failure are pulmonary vascular congestion and pulmonary edema . (brainkart.com)
  • Abstract In the undivided ventricle of noncrocodilian reptiles, the blood perfusing the systemic circulation is a controlled combination of oxygenated pulmonary blood, flowing from left to right across the heart, and relatively deoxygenated systemic blood, flowing from right to left. (meddic.jp)
  • Anatomic features of congenital pulmonary valvar stenosis. (medscape.com)
  • Pulmonary, systemic and lymphatic circulation will also be reviewed and discussed. (ccp.edu)
  • The therapeutic efficacy of long-circulating polyethylene glycol-coated liposomal amphotericin B (AMB) (PEG-AMB-LIP) was compared with that of AMB desoxycholate (Fungizone) in a model of severe invasive pulmonary aspergillosis in persistently leukopenic rats as well as in temporarily leukopenic rats. (eur.nl)
  • In asymptomatic adults with severe valvar pulmonary stenosis, intervention is reasonable (class IIa, LOE: C). (medscape.com)
  • Such reversal and cyanosis can occur when the RV is hypoplastic, even with less severe pulmonary stenosis. (medscape.com)
  • In areas where there is circulation more than one serotype can be severe forms of the infection, characterized by bleeding, circulatory shock and death [ 4 ]. (clinmedjournals.org)
  • The ability to obtain molecular information in vivo would help to understand the abnormalities underlying cardiovascular, pulmonary, and blood diseases, would have profound impact on the diagnosis of these conditions, and could provide rapid and efficient assessment of treatment effectiveness. (nih.gov)
  • Results of the budget impact analysis have shown that the use of the standard therapy + phosphocreatine instead of the standard therapy itself in perioperative management of cardiac surgery patients with extracorporeal circulation, with IHD or with CHI has saved money. (pharmacoeconom.com)
  • Of these, 132 patients had a pulmonary homograft, and 87 had an aortic homograft. (uab.edu)
  • Reoperation rate for patients with aortic homografts (16 of 87) compared with that for pulmonary homografts (16 of 132) was not significantly different by the actuarial method. (uab.edu)
  • The literature has reported direct cardiac and pulmonary involvement in morbidity and mortality of dengue patients [ 5 - 7 ]. (clinmedjournals.org)
  • Typically, the echocardiogram demonstrates evidence of increased pulmonary arterial (PA) pressure, accompanied by an enlarged right ventricle (see the image below). (medscape.com)
  • Information from NHANES III pulmonary studies will be used to provide reference data for occupational exposure research, air quality studies, and specialized cardiovascular research, as well as documentation of the relationship of smoking to COPD. (cdc.gov)
  • RESEARCH OBJECTIVES Background Current methods for imaging the cardiovascular, pulmonary, and hematopoietic systems, such as CT, MRI, and ultrasound focus predominantly on anatomical and functional measurements. (nih.gov)
  • Development of new molecular probes for conventional imaging techniques such as MRI and ultrasound, and application of new technologies such as optical imaging show great promise, but their use in the cardiovascular, pulmonary, and hematopoietic systems is still limited. (nih.gov)
  • METHODS AND RESULTS: Between July 1, 1985, and December 31, 1990, 219 patients had cryopreserved homograft extracardiac valved conduits placed in the pulmonary circuit. (uab.edu)
  • The shape of VICG(H) waveform and values of VICG indices were observed to be markedly affected in patients having significant alteration in the pulmonary circulation and the changes observed were specific of the type of the disorder. (who.int)
  • For asymptomatic patients with residual PR as a result of treatment of isolated pulmonary stenosis with a dilated RV, serial follow-up is recommended (class I, LOE: C). (medscape.com)
  • The prognosis of infundibular pulmonary stenosis (IPS) mainly depends on the severity of stenosis in the absence of any additional lesions. (medscape.com)
  • Pulmonary ventilation and circulation. (unica.it)