The short wide vessel arising from the conus arteriosus of the right ventricle and conveying unaerated blood to the lungs.
The vessels carrying blood away from the heart.
Increased VASCULAR RESISTANCE in the PULMONARY CIRCULATION, usually secondary to HEART DISEASES or LUNG DISEASES.
The circulation of the BLOOD through the LUNGS.
Either of the two principal arteries on both sides of the neck that supply blood to the head and neck; each divides into two branches, the internal carotid artery and the external carotid artery.
A branch of the abdominal aorta which supplies the kidneys, adrenal glands and ureters.
Placement of a balloon-tipped catheter into the pulmonary artery through the antecubital, subclavian, and sometimes the femoral vein. It is used to measure pulmonary artery pressure and pulmonary artery wedge pressure which reflects left atrial pressure and left ventricular end-diastolic pressure. The catheter is threaded into the right atrium, the balloon is inflated and the catheter follows the blood flow through the tricuspid valve into the right ventricle and out into the pulmonary artery.
Arteries which arise from the abdominal aorta and distribute to most of the intestines.
The main artery of the thigh, a continuation of the external iliac artery.
The arterial blood vessels supplying the CEREBRUM.
The artery formed by the union of the right and left vertebral arteries; it runs from the lower to the upper border of the pons, where it bifurcates into the two posterior cerebral arteries.
The blood pressure as recorded after wedging a CATHETER in a small PULMONARY ARTERY; believed to reflect the PRESSURE in the pulmonary CAPILLARIES.
The nonstriated involuntary muscle tissue of blood vessels.
Surgical therapy of ischemic coronary artery disease achieved by grafting a section of saphenous vein, internal mammary artery, or other substitute between the aorta and the obstructed coronary artery distal to the obstructive lesion.
The physiological narrowing of BLOOD VESSELS by contraction of the VASCULAR SMOOTH MUSCLE.
Either of two large arteries originating from the abdominal aorta; they supply blood to the pelvis, abdominal wall and legs.
Artery arising from the brachiocephalic trunk on the right side and from the arch of the aorta on the left side. It distributes to the neck, thoracic wall, spinal cord, brain, meninges, and upper limb.
The first branch of the SUBCLAVIAN ARTERY with distribution to muscles of the NECK; VERTEBRAE; SPINAL CORD; CEREBELLUM; and interior of the CEREBRUM.
Relatively complete absence of oxygen in one or more tissues.
Left bronchial arteries arise from the thoracic aorta, the right from the first aortic intercostal or the upper left bronchial artery; they supply the bronchi and the lower trachea.
The direct continuation of the brachial trunk, originating at the bifurcation of the brachial artery opposite the neck of the radius. Its branches may be divided into three groups corresponding to the three regions in which the vessel is situated, the forearm, wrist, and hand.
The movement and the forces involved in the movement of the blood through the CARDIOVASCULAR SYSTEM.
Arteries originating from the subclavian or axillary arteries and distributing to the anterior thoracic wall, mediastinal structures, diaphragm, pectoral muscles and mammary gland.
Branch of the common carotid artery which supplies the anterior part of the brain, the eye and its appendages, the forehead and nose.
Single pavement layer of cells which line the luminal surface of the entire vascular system and regulate the transport of macromolecules and blood components.
Procedures in which placement of CARDIAC CATHETERS is performed for therapeutic or diagnostic procedures.
The physiological widening of BLOOD VESSELS by relaxing the underlying VASCULAR SMOOTH MUSCLE.
Pathological conditions involving the CAROTID ARTERIES, including the common, internal, and external carotid arteries. ATHEROSCLEROSIS and TRAUMA are relatively frequent causes of carotid artery pathology.
The veins and arteries of the HEART.
The largest branch of the celiac trunk with distribution to the spleen, pancreas, stomach and greater omentum.
The continuation of the axillary artery; it branches into the radial and ulnar arteries.
PRESSURE of the BLOOD on the ARTERIES and other BLOOD VESSELS.
Blocking of the PULMONARY ARTERY or one of its branches by an EMBOLUS.
Drugs used to cause dilation of the blood vessels.
Radiography of blood vessels after injection of a contrast medium.
Either of the pair of organs occupying the cavity of the thorax that effect the aeration of the blood.
Enlargement of the RIGHT VENTRICLE of the heart. This increase in ventricular mass is often attributed to PULMONARY HYPERTENSION and is a contributor to cardiovascular morbidity and mortality.
A branch of the celiac artery that distributes to the stomach, pancreas, duodenum, liver, gallbladder, and greater omentum.
The two principal arteries supplying the structures of the head and neck. They ascend in the neck, one on each side, and at the level of the upper border of the thyroid cartilage, each divides into two branches, the external (CAROTID ARTERY, EXTERNAL) and internal (CAROTID ARTERY, INTERNAL) carotid arteries.
The pathologic narrowing of the orifice of the PULMONARY VALVE. This lesion restricts blood outflow from the RIGHT VENTRICLE to the PULMONARY ARTERY. When the trileaflet valve is fused into an imperforate membrane, the blockage is complete.
A pyrrolizidine alkaloid and a toxic plant constituent that poisons livestock and humans through the ingestion of contaminated grains and other foods. The alkaloid causes pulmonary artery hypertension, right ventricular hypertrophy, and pathological changes in the pulmonary vasculature. Significant attenuation of the cardiopulmonary changes are noted after oral magnesium treatment.
Developmental abnormalities involving structures of the heart. These defects are present at birth but may be discovered later in life.
A congenital heart defect characterized by the narrowing or complete absence of the opening between the RIGHT VENTRICLE and the PULMONARY ARTERY. Lacking a normal PULMONARY VALVE, unoxygenated blood in the right ventricle can not be effectively pumped into the lung for oxygenation. Clinical features include rapid breathing, CYANOSIS, right ventricle atrophy, and abnormal heart sounds (HEART MURMURS).
Developmental abnormalities in any portion of the VENTRICULAR SEPTUM resulting in abnormal communications between the two lower chambers of the heart. Classification of ventricular septal defects is based on location of the communication, such as perimembranous, inlet, outlet (infundibular), central muscular, marginal muscular, or apical muscular defect.
Neoplasms located in the vasculature system, such as ARTERIES and VEINS. They are differentiated from neoplasms of vascular tissue (NEOPLASMS, VASCULAR TISSUE), such as ANGIOFIBROMA or HEMANGIOMA.
The arterial trunk that arises from the abdominal aorta and after a short course divides into the left gastric, common hepatic and splenic arteries.
Drugs used to cause constriction of the blood vessels.
Pathological processes which result in the partial or complete obstruction of ARTERIES. They are characterized by greatly reduced or absence of blood flow through these vessels. They are also known as arterial insufficiency.
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
Artery originating from the internal carotid artery and distributing to the eye, orbit and adjacent facial structures.
A combination of congenital heart defects consisting of four key features including VENTRICULAR SEPTAL DEFECTS; PULMONARY STENOSIS; RIGHT VENTRICULAR HYPERTROPHY; and a dextro-positioned AORTA. In this condition, blood from both ventricles (oxygen-rich and oxygen-poor) is pumped into the body often causing CYANOSIS.
A large vessel supplying the whole length of the small intestine except the superior part of the duodenum. It also supplies the cecum and the ascending part of the colon and about half the transverse part of the colon. It arises from the anterior surface of the aorta below the celiac artery at the level of the first lumbar vertebra.
Tomography using x-ray transmission and a computer algorithm to reconstruct the image.
Malformations of CORONARY VESSELS, either arteries or veins. Included are anomalous origins of coronary arteries; ARTERIOVENOUS FISTULA; CORONARY ANEURYSM; MYOCARDIAL BRIDGING; and others.
A fetal blood vessel connecting the pulmonary artery with the descending aorta.
Non-striated, elongated, spindle-shaped cells found lining the digestive tract, uterus, and blood vessels. They are derived from specialized myoblasts (MYOBLASTS, SMOOTH MUSCLE).
Abnormal communication between two ARTERIES that may result from injury or occur as a congenital abnormality.
Pathological outpouching or sac-like dilatation in the wall of any blood vessel (ARTERIES or VEINS) or the heart (HEART ANEURYSM). It indicates a thin and weakened area in the wall which may later rupture. Aneurysms are classified by location, etiology, or other characteristics.
The volume of BLOOD passing through the HEART per unit of time. It is usually expressed as liters (volume) per minute so as not to be confused with STROKE VOLUME (volume per beat).
The condition of an anatomical structure's being constricted beyond normal dimensions.
The veins that return the oxygenated blood from the lungs to the left atrium of the heart.
Specialized arterial vessels in the umbilical cord. They carry waste and deoxygenated blood from the FETUS to the mother via the PLACENTA. In humans, there are usually two umbilical arteries but sometimes one.
The hemodynamic and electrophysiological action of the right HEART VENTRICLE.
The largest of the cerebral arteries. It trifurcates into temporal, frontal, and parietal branches supplying blood to most of the parenchyma of these lobes in the CEREBRAL CORTEX. These are the areas involved in motor, sensory, and speech activities.
The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065)
A free radical gas produced endogenously by a variety of mammalian cells, synthesized from ARGININE by NITRIC OXIDE SYNTHASE. Nitric oxide is one of the ENDOTHELIUM-DEPENDENT RELAXING FACTORS released by the vascular endothelium and mediates VASODILATION. It also inhibits platelet aggregation, induces disaggregation of aggregated platelets, and inhibits platelet adhesion to the vascular endothelium. Nitric oxide activates cytosolic GUANYLATE CYCLASE and thus elevates intracellular levels of CYCLIC GMP.
Narrowing or occlusion of the RENAL ARTERY or arteries. It is due usually to ATHEROSCLEROSIS; FIBROMUSCULAR DYSPLASIA; THROMBOSIS; EMBOLISM, or external pressure. The reduced renal perfusion can lead to renovascular hypertension (HYPERTENSION, RENOVASCULAR).
Arteries originating from the subclavian or axillary arteries and distributing to the anterior thoracic wall, mediastinal structures, diaphragm, pectoral muscles, mammary gland and the axillary aspect of the chest wall.
Elements of limited time intervals, contributing to particular results or situations.
Radiography of the vascular system of the heart muscle after injection of a contrast medium.
The force that opposes the flow of BLOOD through a vascular bed. It is equal to the difference in BLOOD PRESSURE across the vascular bed divided by the CARDIAC OUTPUT.
Arteries arising from the external carotid or the maxillary artery and distributing to the temporal region.
A congenital cardiovascular malformation in which the AORTA arises entirely from the RIGHT VENTRICLE, and the PULMONARY ARTERY arises from the LEFT VENTRICLE. Consequently, the pulmonary and the systemic circulations are parallel and not sequential, so that the venous return from the peripheral circulation is re-circulated by the right ventricle via aorta to the systemic circulation without being oxygenated in the lungs. This is a potentially lethal form of heart disease in newborns and infants.
Any of various animals that constitute the family Suidae and comprise stout-bodied, short-legged omnivorous mammals with thick skin, usually covered with coarse bristles, a rather long mobile snout, and small tail. Included are the genera Babyrousa, Phacochoerus (wart hogs), and Sus, the latter containing the domestic pig (see SUS SCROFA).
A congenital heart defect characterized by the persistent opening of fetal DUCTUS ARTERIOSUS that connects the PULMONARY ARTERY to the descending aorta (AORTA, DESCENDING) allowing unoxygenated blood to bypass the lung and flow to the PLACENTA. Normally, the ductus is closed shortly after birth.
The continuation of the femoral artery coursing through the popliteal fossa; it divides into the anterior and posterior tibial arteries.
The larger of the two terminal branches of the brachial artery, beginning about one centimeter distal to the bend of the elbow. Like the RADIAL ARTERY, its branches may be divided into three groups corresponding to their locations in the forearm, wrist, and hand.
Use or insertion of a tubular device into a duct, blood vessel, hollow organ, or body cavity for injecting or withdrawing fluids for diagnostic or therapeutic purposes. It differs from INTUBATION in that the tube here is used to restore or maintain patency in obstructions.
Measurement of intracardiac blood flow using an M-mode and/or two-dimensional (2-D) echocardiogram while simultaneously recording the spectrum of the audible Doppler signal (e.g., velocity, direction, amplitude, intensity, timing) reflected from the moving column of red blood cells.
A valve situated at the entrance to the pulmonary trunk from the right ventricle.
Ultrasonic recording of the size, motion, and composition of the heart and surrounding tissues. The standard approach is transthoracic.
The main trunk of the systemic arteries.
A stable prostaglandin endoperoxide analog which serves as a thromboxane mimetic. Its actions include mimicking the hydro-osmotic effect of VASOPRESSIN and activation of TYPE C PHOSPHOLIPASES. (From J Pharmacol Exp Ther 1983;224(1): 108-117; Biochem J 1984;222(1):103-110)
A branch arising from the internal iliac artery in females, that supplies blood to the uterus.
The portion of the descending aorta proceeding from the arch of the aorta and extending to the DIAPHRAGM, eventually connecting to the ABDOMINAL AORTA.
Branch of the common carotid artery which supplies the exterior of the head, the face, and the greater part of the neck.
Devices that provide support for tubular structures that are being anastomosed or for body cavities during skin grafting.
The flow of BLOOD through or around an organ or region of the body.
A procedure in which total right atrial or total caval blood flow is channeled directly into the pulmonary artery or into a small right ventricle that serves only as a conduit. The principal congenital malformations for which this operation is useful are TRICUSPID ATRESIA and single ventricle with pulmonary stenosis.
A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.
An imbalance between myocardial functional requirements and the capacity of the CORONARY VESSELS to supply sufficient blood flow. It is a form of MYOCARDIAL ISCHEMIA (insufficient blood supply to the heart muscle) caused by a decreased capacity of the coronary vessels.
Surgery performed on the heart.
Any of the ruminant mammals with curved horns in the genus Ovis, family Bovidae. They possess lachrymal grooves and interdigital glands, which are absent in GOATS.
Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.
Measurement of blood flow based on induction at one point of the circulation of a known change in the intravascular heat content of flowing blood and detection of the resultant change in temperature at a point downstream.
The relationship between the dose of an administered drug and the response of the organism to the drug.
A 21-amino acid peptide produced in a variety of tissues including endothelial and vascular smooth-muscle cells, neurons and astrocytes in the central nervous system, and endometrial cells. It acts as a modulator of vasomotor tone, cell proliferation, and hormone production. (N Eng J Med 1995;333(6):356-63)
Damages to the CAROTID ARTERIES caused either by blunt force or penetrating trauma, such as CRANIOCEREBRAL TRAUMA; THORACIC INJURIES; and NECK INJURIES. Damaged carotid arteries can lead to CAROTID ARTERY THROMBOSIS; CAROTID-CAVERNOUS SINUS FISTULA; pseudoaneurysm formation; and INTERNAL CAROTID ARTERY DISSECTION. (From Am J Forensic Med Pathol 1997, 18:251; J Trauma 1994, 37:473)
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.
Application of a ligature to tie a vessel or strangulate a part.
The species Oryctolagus cuniculus, in the family Leporidae, order LAGOMORPHA. Rabbits are born in burrows, furless, and with eyes and ears closed. In contrast with HARES, rabbits have 22 chromosome pairs.
A condition in which the RIGHT VENTRICLE of the heart was functionally impaired. This condition usually leads to HEART FAILURE or MYOCARDIAL INFARCTION, and other cardiovascular complications. Diagnosis is made by measuring the diminished ejection fraction and a depressed level of motility of the right ventricular wall.
That phase of a muscle twitch during which a muscle returns to a resting position.
Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.
A strain of albino rat developed at the Wistar Institute that has spread widely at other institutions. This has markedly diluted the original strain.
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
The act of constricting.
Non-invasive method of vascular imaging and determination of internal anatomy without injection of contrast media or radiation exposure. The technique is used especially in CEREBRAL ANGIOGRAPHY as well as for studies of other vascular structures.
A condition caused by underdevelopment of the whole left half of the heart. It is characterized by hypoplasia of the left cardiac chambers (HEART ATRIUM; HEART VENTRICLE), the AORTA, the AORTIC VALVE, and the MITRAL VALVE. Severe symptoms appear in early infancy when DUCTUS ARTERIOSUS closes.
Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.
The circulation of blood through the CORONARY VESSELS of the HEART.
Backflow of blood from the RIGHT VENTRICLE into the RIGHT ATRIUM due to imperfect closure of the TRICUSPID VALVE.
A neurotransmitter found at neuromuscular junctions, autonomic ganglia, parasympathetic effector junctions, a subset of sympathetic effector junctions, and at many sites in the central nervous system.
Use of a balloon catheter for dilation of an occluded artery. It is used in treatment of arterial occlusive diseases, including renal artery stenosis and arterial occlusions in the leg. For the specific technique of BALLOON DILATION in coronary arteries, ANGIOPLASTY, BALLOON, CORONARY is available.
The lower right and left chambers of the heart. The right ventricle pumps venous BLOOD into the LUNGS and the left ventricle pumps oxygenated blood into the systemic arterial circulation.
An element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on earth and essential for respiration.
A prostaglandin that is a powerful vasodilator and inhibits platelet aggregation. It is biosynthesized enzymatically from PROSTAGLANDIN ENDOPEROXIDES in human vascular tissue. The sodium salt has been also used to treat primary pulmonary hypertension (HYPERTENSION, PULMONARY).
An NADPH-dependent enzyme that catalyzes the conversion of L-ARGININE and OXYGEN to produce CITRULLINE and NITRIC OXIDE.
A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.
NECROSIS occurring in the MIDDLE CEREBRAL ARTERY distribution system which brings blood to the entire lateral aspects of each CEREBRAL HEMISPHERE. Clinical signs include impaired cognition; APHASIA; AGRAPHIA; weak and numbness in the face and arms, contralaterally or bilaterally depending on the infarction.
The continuation of the subclavian artery; it distributes over the upper limb, axilla, chest and shoulder.
A spectrum of congenital, inherited, or acquired abnormalities in BLOOD VESSELS that can adversely affect the normal blood flow in ARTERIES or VEINS. Most are congenital defects such as abnormal communications between blood vessels (fistula), shunting of arterial blood directly into veins bypassing the CAPILLARIES (arteriovenous malformations), formation of large dilated blood blood-filled vessels (cavernous angioma), and swollen capillaries (capillary telangiectases). In rare cases, vascular malformations can result from trauma or diseases.
Pathologic processes that affect patients after a surgical procedure. They may or may not be related to the disease for which the surgery was done, and they may or may not be direct results of the surgery.
A congenital anomaly caused by the failed development of TRUNCUS ARTERIOSUS into separate AORTA and PULMONARY ARTERY. It is characterized by a single arterial trunk that forms the outlet for both HEART VENTRICLES and gives rise to the systemic, pulmonary, and coronary arteries. It is always accompanied by a ventricular septal defect.
Expectoration or spitting of blood originating from any part of the RESPIRATORY TRACT, usually from hemorrhage in the lung parenchyma (PULMONARY ALVEOLI) and the BRONCHIAL ARTERIES.
Ultrasonography applying the Doppler effect, with frequency-shifted ultrasound reflections produced by moving targets (usually red blood cells) in the bloodstream along the ultrasound axis in direct proportion to the velocity of movement of the targets, to determine both direction and velocity of blood flow. (Stedman, 25th ed)
A powerful vasodilator used in emergencies to lower blood pressure or to improve cardiac function. It is also an indicator for free sulfhydryl groups in proteins.
Sudden ISCHEMIA in the RETINA due to blocked blood flow through the CENTRAL RETINAL ARTERY or its branches leading to sudden complete or partial loss of vision, respectively, in the eye.
A CALCIUM-dependent, constitutively-expressed form of nitric oxide synthase found primarily in ENDOTHELIAL CELLS.
Precursor of epinephrine that is secreted by the adrenal medulla and is a widespread central and autonomic neurotransmitter. Norepinephrine is the principal transmitter of most postganglionic sympathetic fibers and of the diffuse projection system in the brain arising from the locus ceruleus. It is also found in plants and is used pharmacologically as a sympathomimetic.
A method of hemostasis utilizing various agents such as Gelfoam, silastic, metal, glass, or plastic pellets, autologous clot, fat, and muscle as emboli. It has been used in the treatment of spinal cord and INTRACRANIAL ARTERIOVENOUS MALFORMATIONS, renal arteriovenous fistulas, gastrointestinal bleeding, epistaxis, hypersplenism, certain highly vascular tumors, traumatic rupture of blood vessels, and control of operative hemorrhage.
A syndrome of persistent PULMONARY HYPERTENSION in the newborn infant (INFANT, NEWBORN) without demonstrable HEART DISEASES. This neonatal condition can be caused by severe pulmonary vasoconstriction (reactive type), hypertrophy of pulmonary arterial muscle (hypertrophic type), or abnormally developed pulmonary arterioles (hypoplastic type). The newborn patient exhibits CYANOSIS and ACIDOSIS due to the persistence of fetal circulatory pattern of right-to-left shunting of blood through a patent ductus arteriosus (DUCTUS ARTERIOSUS, PATENT) and at times a patent foramen ovale (FORAMEN OVALE, PATENT).
Hypertrophy and dilation of the RIGHT VENTRICLE of the heart that is caused by PULMONARY HYPERTENSION. This condition is often associated with pulmonary parenchymal or vascular diseases, such as CHRONIC OBSTRUCTIVE PULMONARY DISEASE and PULMONARY EMBOLISM.
Surgical union or shunt between ducts, tubes or vessels. It may be end-to-end, end-to-side, side-to-end, or side-to-side.
Blood clot formation in any part of the CAROTID ARTERIES. This may produce CAROTID STENOSIS or occlusion of the vessel, leading to TRANSIENT ISCHEMIC ATTACK; CEREBRAL INFARCTION; or AMAUROSIS FUGAX.
Diversion of the flow of blood from the entrance of the right atrium directly to the aorta (or femoral artery) via an oxygenator thus bypassing both the heart and lungs.
Diversion of the flow of blood from the entrance to the right atrium directly to the pulmonary arteries, avoiding the right atrium and right ventricle (Dorland, 28th ed). This a permanent procedure often performed to bypass a congenitally deformed right atrium or right ventricle.
Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care. (Dictionary of Health Services Management, 2d ed)
The blood pressure in the ARTERIES. It is commonly measured with a SPHYGMOMANOMETER on the upper arm which represents the arterial pressure in the BRACHIAL ARTERY.
Arteries which supply the dura mater.
Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction.
Operative procedures for the treatment of vascular disorders.
In screening and diagnostic tests, the probability that a person with a positive test is a true positive (i.e., has the disease), is referred to as the predictive value of a positive test; whereas, the predictive value of a negative test is the probability that the person with a negative test does not have the disease. Predictive value is related to the sensitivity and specificity of the test.
A white crystal or crystalline powder used in BUFFERS; FERTILIZERS; and EXPLOSIVES. It can be used to replenish ELECTROLYTES and restore WATER-ELECTROLYTE BALANCE in treating HYPOKALEMIA.
Backflow of blood from the PULMONARY ARTERY into the RIGHT VENTRICLE due to imperfect closure of the PULMONARY VALVE.
Excessive accumulation of extravascular fluid in the lung, an indication of a serious underlying disease or disorder. Pulmonary edema prevents efficient PULMONARY GAS EXCHANGE in the PULMONARY ALVEOLI, and can be life-threatening.
Domesticated bovine animals of the genus Bos, usually kept on a farm or ranch and used for the production of meat or dairy products or for heavy labor.
The continuous measurement of physiological processes, blood pressure, heart rate, renal output, reflexes, respiration, etc., in a patient or experimental animal; includes pharmacologic monitoring, the measurement of administered drugs or their metabolites in the blood, tissues, or urine.
Rhythmic, intermittent propagation of a fluid through a BLOOD VESSEL or piping system, in contrast to constant, smooth propagation, which produces laminar flow.
A basic element found in nearly all organized tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes.
A condition associated with VENTRICULAR SEPTAL DEFECT and other congenital heart defects that allow the mixing of pulmonary and systemic circulation, increase blood flow into the lung, and subsequent responses to low oxygen in blood. This complex is characterized by progressive PULMONARY HYPERTENSION; HYPERTROPHY of the RIGHT VENTRICLE; CYANOSIS; and ERYTHROCYTOSIS.
Narrowing or stricture of any part of the CAROTID ARTERIES, most often due to atherosclerotic plaque formation. Ulcerations may form in atherosclerotic plaques and induce THROMBUS formation. Platelet or cholesterol emboli may arise from stenotic carotid lesions and induce a TRANSIENT ISCHEMIC ATTACK; CEREBROVASCULAR ACCIDENT; or temporary blindness (AMAUROSIS FUGAX). (From Adams et al., Principles of Neurology, 6th ed, pp 822-3)
Not an aneurysm but a well-defined collection of blood and CONNECTIVE TISSUE outside the wall of a blood vessel or the heart. It is the containment of a ruptured blood vessel or heart, such as sealing a rupture of the left ventricle. False aneurysm is formed by organized THROMBUS and HEMATOMA in surrounding tissue.
Recording of the moment-to-moment electromotive forces of the HEART as projected onto various sites on the body's surface, delineated as a scalar function of time. The recording is monitored by a tracing on slow moving chart paper or by observing it on a cardioscope, which is a CATHODE RAY TUBE DISPLAY.
An alpha-1 adrenergic agonist used as a mydriatic, nasal decongestant, and cardiotonic agent.
Radiography of the heart and great vessels after injection of a contrast medium.
Death resulting from the presence of a disease in an individual, as shown by a single case report or a limited number of patients. This should be differentiated from DEATH, the physiological cessation of life and from MORTALITY, an epidemiological or statistical concept.
The inferior and superior venae cavae.
A subtype of bone morphogenetic protein receptors with low affinity for BONE MORPHOGENETIC PROTEINS. They are constitutively active PROTEIN-SERINE-THREONINE KINASES that can interact with and phosphorylate TYPE I BONE MORPHOGENETIC PROTEIN RECEPTORS.
An infant during the first month after birth.
A biochemical messenger and regulator, synthesized from the essential amino acid L-TRYPTOPHAN. In humans it is found primarily in the central nervous system, gastrointestinal tract, and blood platelets. Serotonin mediates several important physiological functions including neurotransmission, gastrointestinal motility, hemostasis, and cardiovascular integrity. Multiple receptor families (RECEPTORS, SEROTONIN) explain the broad physiological actions and distribution of this biochemical mediator.
Heart sounds caused by vibrations resulting from the flow of blood through the heart. Heart murmurs can be examined by HEART AUSCULTATION, and analyzed by their intensity (6 grades), duration, timing (systolic, diastolic, or continuous), location, transmission, and quality (musical, vibratory, blowing, etc).
An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.
The state of activity or tension of a muscle beyond that related to its physical properties, that is, its active resistance to stretch. In skeletal muscle, tonus is dependent upon efferent innervation. (Stedman, 25th ed)
The degree to which BLOOD VESSELS are not blocked or obstructed.
Radiography of the vascular system of the brain after injection of a contrast medium.
Surgical excision, performed under general anesthesia, of the atheromatous tunica intima of an artery. When reconstruction of an artery is performed as an endovascular procedure through a catheter, it is called ATHERECTOMY.
A non-selective inhibitor of nitric oxide synthase. It has been used experimentally to induce hypertension.
An eicosanoid, derived from the cyclooxygenase pathway of arachidonic acid metabolism. It is a stable and synthetic analog of EPOPROSTENOL, but with a longer half-life than the parent compound. Its actions are similar to prostacyclin. Iloprost produces vasodilation and inhibits platelet aggregation.
Highly specialized EPITHELIAL CELLS that line the HEART; BLOOD VESSELS; and lymph vessels, forming the ENDOTHELIUM. They are polygonal in shape and joined together by TIGHT JUNCTIONS. The tight junctions allow for variable permeability to specific macromolecules that are transported across the endothelial layer.
Surgical insertion of BLOOD VESSEL PROSTHESES to repair injured or diseased blood vessels.
Guanosine cyclic 3',5'-(hydrogen phosphate). A guanine nucleotide containing one phosphate group which is esterified to the sugar moiety in both the 3'- and 5'-positions. It is a cellular regulatory agent and has been described as a second messenger. Its levels increase in response to a variety of hormones, including acetylcholine, insulin, and oxytocin and it has been found to activate specific protein kinases. (From Merck Index, 11th ed)
NECROSIS of the MYOCARDIUM caused by an obstruction of the blood supply to the heart (CORONARY CIRCULATION).
Narrowing or constriction of a coronary artery.
The amount of BLOOD pumped out of the HEART per beat, not to be confused with cardiac output (volume/time). It is calculated as the difference between the end-diastolic volume and the end-systolic volume.
Cell surface proteins that bind ENDOTHELINS with high affinity and trigger intracellular changes which influence the behavior of cells.
The condition of an anatomical structure's being dilated beyond normal dimensions.
Controlled physical activity which is performed in order to allow assessment of physiological functions, particularly cardiovascular and pulmonary, but also aerobic capacity. Maximal (most intense) exercise is usually required but submaximal exercise is also used.
Radiographic visualization of the aorta and its branches by injection of contrast media, using percutaneous puncture or catheterization procedures.
A branch of the external carotid artery which distributes to the deep structures of the face (internal maxillary) and to the side of the face and nose (external maxillary).
Levels within a diagnostic group which are established by various measurement criteria applied to the seriousness of a patient's disorder.
A volatile vasodilator which relieves ANGINA PECTORIS by stimulating GUANYLATE CYCLASE and lowering cytosolic calcium. It is also sometimes used for TOCOLYSIS and explosives.
Device constructed of either synthetic or biological material that is used for the repair of injured or diseased blood vessels.
A group of intracellular-signaling serine threonine kinases that bind to RHO GTP-BINDING PROTEINS. They were originally found to mediate the effects of rhoA GTP-BINDING PROTEIN on the formation of STRESS FIBERS and FOCAL ADHESIONS. Rho-associated kinases have specificity for a variety of substrates including MYOSIN-LIGHT-CHAIN PHOSPHATASE and LIM KINASES.
A value equal to the total volume flow divided by the cross-sectional area of the vascular bed.
The number of times the HEART VENTRICLES contract per unit of time, usually per minute.
The tearing or bursting of the weakened wall of the aneurysmal sac, usually heralded by sudden worsening pain. The great danger of a ruptured aneurysm is the large amount of blood spilling into the surrounding tissues and cavities, causing HEMORRHAGIC SHOCK.
The splitting of the vessel wall in one or both (left and right) internal carotid arteries (CAROTID ARTERY, INTERNAL). Interstitial hemorrhage into the media of the vessel wall can lead to occlusion of the internal carotid artery and aneurysm formation.
The neural systems which act on VASCULAR SMOOTH MUSCLE to control blood vessel diameter. The major neural control is through the sympathetic nervous system.
Ultrasonography applying the Doppler effect, with the superposition of flow information as colors on a gray scale in a real-time image. This type of ultrasonography is well-suited to identifying the location of high-velocity flow (such as in a stenosis) or of mapping the extent of flow in a certain region.
Insertion of a catheter into a peripheral artery, vein, or airway for diagnostic or therapeutic purposes.
Theoretical representations that simulate the behavior or activity of the cardiovascular system, processes, or phenomena; includes the use of mathematical equations, computers and other electronic equipment.
The recording of muscular movements. The apparatus is called a myograph, the record or tracing, a myogram. (From Stedman, 25th ed)
The hollow, muscular organ that maintains the circulation of the blood.
Coronary artery bypass surgery on a beating HEART without a CARDIOPULMONARY BYPASS (diverting the flow of blood from the heart and lungs through an oxygenator).
Ultrasonic recording of the size, motion, and composition of the heart and surrounding tissues using a transducer placed in the esophagus.
Direct myocardial revascularization in which the internal mammary artery is anastomosed to the right coronary artery, circumflex artery, or anterior descending coronary artery. The internal mammary artery is the most frequent choice, especially for a single graft, for coronary artery bypass surgery.
A condition of decreased oxygen content at the cellular level.
Multiple symptoms associated with reduced oxygen at high ALTITUDE.
A method of delineating blood vessels by subtracting a tissue background image from an image of tissue plus intravascular contrast material that attenuates the X-ray photons. The background image is determined from a digitized image taken a few moments before injection of the contrast material. The resulting angiogram is a high-contrast image of the vessel. This subtraction technique allows extraction of a high-intensity signal from the superimposed background information. The image is thus the result of the differential absorption of X-rays by different tissues.

Induction of serotonin transporter by hypoxia in pulmonary vascular smooth muscle cells. Relationship with the mitogenic action of serotonin. (1/5022)

-The increased delivery of serotonin (5-hydroxytryptamine, 5-HT) to the lung aggravates the development of hypoxia-induced pulmonary hypertension in rats, possibly through stimulation of the proliferation of pulmonary artery smooth muscle cells (PA-SMCs). In cultured rat PA-SMCs, 5-HT (10(-8) to 10(-6) mol/L) induced DNA synthesis and potentiated the mitogenic effect of platelet-derived growth factor-BB (10 ng/mL). This effect was dependent on the 5-HT transporter (5-HTT), since it was prevented by the 5-HTT inhibitors fluoxetine (10(-6) mol/L) and paroxetine (10(-7) mol/L), but it was unaltered by ketanserin (10(-6) mol/L), a 5-HT2A receptor antagonist. In PA-SMCs exposed to hypoxia, the levels of 5-HTT mRNA (measured by competitive reverse transcriptase-polymerase chain reaction) increased by 240% within 2 hours, followed by a 3-fold increase in the uptake of [3H]5-HT at 24 hours. Cotransfection of the cells with a construct of human 5-HTT promoter-luciferase gene reporter and of pCMV-beta-galactosidase gene allowed the demonstration that exposure of cells to hypoxia produced a 5.5-fold increase in luciferase activity, with no change in beta-galactosidase activity. The increased expression of 5-HTT in hypoxic cells was associated with a greater mitogenic response to 5-HT (10(-8) to 10(-6) mol/L) in the absence as well as in the presence of platelet-derived growth factor-BB. 5-HTT expression assessed by quantitative reverse transcriptase-polymerase chain reaction and in situ hybridization in the lungs was found to predominate in the media of pulmonary artery, in which a marked increase was noted in rats that had been exposed to hypoxia for 15 days. These data show that in vitro and in vivo exposure to hypoxia induces, via a transcriptional mechanism, 5-HTT expression in PA-SMCs, and that this effect contributes to the stimulatory action of 5-HT on PA-SMC proliferation. In vivo expression of 5-HTT by PA-SMC may play a key role in serotonin-mediated pulmonary vascular remodeling.  (+info)

Relaxation of endothelin-1-induced pulmonary arterial constriction by niflumic acid and NPPB: mechanism(s) independent of chloride channel block. (2/5022)

We investigated the effects of the Cl- channel blockers niflumic acid, 5-nitro-2-(3-phenylpropylamino)-benzoic acid (NPPB) and 4, 4'-diisothiocyanatostilbene-2,2'-disulphonic acid (DIDS) on endothelin-1 (ET-1)-induced constriction of rat small pulmonary arteries (diameter 100-400 microm) in vitro, following endothelium removal. ET-1 (30 nM) induced a sustained constriction of rat pulmonary arteries in physiological salt solution. Arteries preconstricted with ET-1 were relaxed by niflumic acid (IC50: 35.8 microM) and NPPB (IC50: 21.1 microM) in a reversible and concentration-dependent manner. However, at concentrations known to block Ca++-activated Cl- channels, DIDS (+info)

Transcriptional down-regulation of the rabbit pulmonary artery endothelin B receptor during phenotypic modulation. (3/5022)

1. We confirmed that endothelium-independent contraction of the rabbit pulmonary artery (RPA) is mediated through both an endothelin A (ET(A)R) and endothelin B (ET(B2)R) receptor. 2. The response of endothelium-denuded RPA rings to endothelin-1 (ET-1, pD2 = 7.84 +/- 0.03) was only partially inhibited by BQ123 (10 microM), an ET(A)R antagonist. 3. Pretreatment with 1 nM sarafotoxin S6c (S6c), an ET(B)R agonist, desensitized the ET(B2)R and significantly attenuated the response to ET-3 (pD2 = 7.40 +/- 0.02 before, <6.50 after S6c). 4. Pretreatment with S6c had little effect on the response to ET-1, but BQ123 (10 microM) caused a parallel shift to the right of the residual ETAR-mediated response to ET-1 (pD2 = 7.84 +/- 0.03 before S6c, 7.93 +/- 0.03 after S6c, 6.81 +/- 0.05 after BQ123). 5. Binding of radiolabelled ET-1 to early passage cultures of RPA vascular smooth muscle cells (VSMC) displayed two patterns of competitive displacement characteristic of the ET(A)R (BQ123 pIC50 = 8.73 +/- 0.05) or ET(B2)R (S6c pIC50 = 10.15). 6. Competitive displacement experiments using membranes from late passage VSMC confirmed only the presence of the ET(A)R (ET-1 pIC50 = 9.3, BQ123 pIC50 = 8.0, S6c pIC50 < 6.0). 7. The ET(A)R was functionally active and coupled to rises in intracellular calcium which exhibited prolonged homologous desensitization. 8. Using a reverse transcriptase polymerase chain reaction for the rabbit ET(B2)R, we demonstrated the absence of mRNA expression in phenotypically modified VSMC. 9. We conclude that the ET(B2)R expressed by VSMC which mediates contraction of RPA is rapidly down-regulated at the transcriptional level during phenotypic modulation in vitro.  (+info)

Protein kinase C-activated oxidant generation in endothelial cells signals intercellular adhesion molecule-1 gene transcription. (4/5022)

We tested the hypothesis that activation of protein kinase C (PKC) and generation of oxidants are critical sequential signals mediating tumor necrosis factor (TNF)-alpha-induced activation of nuclear factor-kappaB (NF-kappaB) and transcription of the intercellular adhesion molecule (ICAM)-1 gene. Stimulation of human pulmonary artery endothelial (HPAE) cells with TNF-alpha (100 U/ml) induced the activation of PKC and, subsequently, generation of oxidants. Pretreatment with calphostin C, a specific PKC inhibitor, prevented oxidant generation after TNF-alpha stimulation, indicating that PKC activation mediated the production of oxidants in HPAE cells. In contrast, pretreatment of HPAE cells with N-acetylcysteine, an antioxidant and a precursor of glutathione, failed to prevent PKC activation, indicating that PKC activation was not secondary to the oxidant production. These findings suggest that oxidant generation in endothelial cells occurs downstream of PKC activation. However, both PKC activation and oxidant generation were necessary for ICAM-1 mRNA expression because the pretreatment of HPAE cells with either calphostin C or N-acetylcysteine inhibited the TNF-alpha-induced activation of NF-kappaB and prevented the activation of ICAM-1 promoter. Prolonged exposure of HPAE cells to the phorbol ester, phorbol-12-myristate-13-acetate, which is known to deplete all except atypical PKC isozymes, failed to prevent TNF-alpha-induced ICAM-1 mRNA expression. We conclude that TNF-alpha-induced oxidant generation secondary to the activation of a phorbol ester-insensitive PKC isozyme signals the activation NF-kappaB and ICAM-1 gene transcription.  (+info)

Anomalous origin of the left coronary artery from the pulmonary artery: natural history and normal pregnancies. (5/5022)

Two female patients are described with anomalous origin of the left coronary artery arising from the pulmonary artery who sustained an anterolateral myocardial infarction in infancy. Neither patient received surgical treatment although both have lived to middle age with minimal cardiovascular problems and have had uncomplicated pregnancies. Good exercise tolerance and long term survival may be possible even without surgery for patients with this anomaly.  (+info)

Lactate kinetics at rest and during exercise in lambs with aortopulmonary shunts. (6/5022)

In a previous study [G. C. M. Beaufort-Krol, J. Takens, M. C. Molenkamp, G. B. Smid, J. J. Meuzelaar, W. G. Zijlstra, and J. R. G. Kuipers. Am. J. Physiol. 275 (Heart Circ. Physiol. 44): H1503-H1512, 1998], a lower systemic O2 supply was found in lambs with aortopulmonary left-to-right shunts. To determine whether the lower systemic O2 supply results in increased anaerobic metabolism, we used [1-13C]lactate to investigate lactate kinetics in eight 7-wk-old lambs with shunts and eight control lambs, at rest and during moderate exercise [treadmill; 50% of peak O2 consumption (VO2)]. The mean left-to-right shunt fraction in the shunt lambs was 55 +/- 3% of pulmonary blood flow. Arterial lactate concentrations and the rate of appearance (Ra) and disappearance (Rd) of lactate were similar in shunt and control lambs, both at rest (lactate: 1, 201 +/- 76 vs. 1,214 +/- 151 micromol/l; Ra = Rd: 12.97 +/- 1.71 vs. 12.55 +/- 1.25 micromol. min-1. kg-1) and during a similar relative workload. We found a positive correlation between Ra and systemic blood flow, O2 supply, and VO2 in both groups of lambs. In conclusion, shunt lambs have similar lactate kinetics as do control lambs, both at rest and during moderate exercise at a similar fraction of their peak VO2, despite a lower systemic O2 supply.  (+info)

Role of Rho and Rho kinase in the activation of volume-regulated anion channels in bovine endothelial cells. (7/5022)

1. We have studied the modulation of volume-regulated anion channels (VRACs) by the small GTPase Rho and by one of its targets, Rho kinase, in calf pulmonary artery endothelial (CPAE) cells. 2. RT-PCR and immunoblot analysis showed that both RhoA and Rho kinase are expressed in CPAE cells. 3. ICl,swell, the chloride current through VRACs, was activated by challenging CPAE cells with a 25 % hypotonic extracellular solution (HTS) or by intracellular perfusion with a pipette solution containing 100 microM GTPgammaS. 4. Pretreatment of CPAE cells with the Clostridium C2IN-C3 fusion toxin, which inactivates Rho by ADP ribosylation, significantly impaired the activation of ICl,swell in response to the HTS. The current density at +100 mV was 49 +/- 13 pA pF-1 (n = 17) in pretreated cells compared with 172 +/- 17 pA pF-1 (n = 21) in control cells. 5. The volume-independent activation of ICl,swell by intracellular perfusion with GTPgammaS was also impaired in C2IN-C3-pretreated cells (31 +/- 7 pA pF-1, n = 11) compared with non-treated cells (132 +/- 21 pA pF-1, n = 15). 6. Activation of ICl,swell was pertussis toxin (PTX) insensitive. 7. Y-27632, a blocker of Rho kinase, inhibited ICl,swell and delayed its activation. 8. Inhibition of Rho and of Rho kinase by the above-described treatments did not affect the extent of cell swelling in response to HTS. 9. These experiments provide strong evidence that the Rho-Rho kinase pathway is involved in the VRAC activation cascade.  (+info)

Release of Ca2+ from the sarcoplasmic reticulum increases mitochondrial [Ca2+] in rat pulmonary artery smooth muscle cells. (8/5022)

1. The Ca2+-sensitive fluorescent indicator rhod-2 was used to measure mitochondrial [Ca2+] ([Ca2+]m) in single smooth muscle cells from the rat pulmonary artery, while simultaneously monitoring cytosolic [Ca2+] ([Ca2+]i) with fura-2. 2. Application of caffeine produced an increase in [Ca2+]i and also increased [Ca2+]m. The increase in [Ca2+]m occurred after the increase in [Ca2+]i, and remained elevated for a considerable time after [Ca2+]i had returned to resting values. 3. The protonophore carbonyl cyanide p-(trifluoromethoxy)phenylhydrazone (FCCP), which causes the mitochondrial membrane potential to collapse, markedly attenuated the increase in [Ca2+]m following caffeine application and also increased the half-time for recovery of [Ca2+]i to resting values. 4. Activation of purinoceptors with ATP also produced increases in both [Ca2+]i and [Ca2+]m in these smooth muscle cells. In some cells, oscillations in [Ca2+]i were observed during ATP application, which produced corresponding oscillations in [Ca2+]m and membrane currents. 5. This study provides direct evidence that Ca2+ release from the sarcoplasmic reticulum, either through ryanodine or inositol 1,4, 5-trisphosphate (InsP3) receptors, increases both cytosolic and mitochondrial [Ca2+] in smooth muscle cells. These results have potential implications both for the role of mitochondria in Ca2+ regulation in smooth muscle, and for understanding how cellular metabolism is regulated.  (+info)

Two-dimensional suprasternal notch echocardiograms of the right pulmonary artery were obtained in 50 normal infants and children to determine the right pulmonary artery diameter. An excellent nonlinear correlation between the right pulmonary artery diameter (RPA) in cm and body surface area (BSA) in m2was observed: RPA (systole) = 1.41 (BSA)051, r = 0.94 and RPA (diastole) = 1.28 (BSA)0.52, r = 0.93. These data were utilized to calculate the normal range (3rd and 97th percentiles) of right pulmonary artery diameter as a function of body surface area. The right pulmonary artery diameter was also measured in 37 patients with tetralogy of Fallot, 30 patients with a secundum atrial septal defect and 12 patients with pulmonary valve insufficiency of various causes. Pulmonary artery diameter was less than the 3rd percentile for body surface area in 16 of the 37 patients with tetralogy of Fallot, but it exceeded the 97th percentile in 17 of the 30 patients with an atrial septal defect and 8 of the 12 ...
TY - JOUR. T1 - MicroRNA expression profile of pulmonary artery smooth muscle cells and the effect of let-7d in chronic thromboembolic pulmonary hypertension. AU - Wang, Lei. AU - Guo, Li Juan. AU - Liu, Jie. AU - Wang, Wang. AU - Yuan, Jason X.J.. AU - Zhao, Lan. AU - Wang, Jun. AU - Wang, Chen. PY - 2013/9. Y1 - 2013/9. N2 - Chronic thromboembolic pulmonary hypertension (CTEPH) is a life-threatening condition characterized by single or recurrent pulmonary thromboemboli, which promote pulmonary vascular remodeling. MicroRNA (miRNA), is a small, noncoding RNA that is involved in multiple cell processes and functions and may participate in the pathogenesis of CTEPH. Our aims were to identify the miRNA expression signature in pulmonary artery smooth muscle cells (PASMCs) of CTEPH patients and to study the role of let-7d in CTEPH pathogenesis. The miRNA expression profile was analyzed by microarray in PASMCs of CTEPH and control patients. Differentially expressed miRNAs were selectively validated ...
Atherosclerosis and coronary heart disease (CHD) are significant contributors to morbidity and mortality in developed countries. A noted exception is the low mortality of CHD in France, particularly the southwest region. This phenomenon, commonly referred to as the French paradox, may be associated with high consumption of red wine. We investigate whether the cardioprotective activity of red wine may involve the grape skin-derived polyphenol, resveratrol. We further test the possibility that resveratrol acts by modulating structural and functional changes in endothelial cells lining the blood vessel wall. Bovine pulmonary artery endothelial cells (BPAEC) were incubated with resveratrol, with and without concurrent exposure to simulated arterial shear stress. Resveratrol significantly affected proliferation and shape of BPAEC; growth was suppressed and cells became elongated, based on morphologic analysis of rhodamine-conjugated phalloidin stained F-actin by confocal microscopy. Using selective signaling
TY - JOUR. T1 - Cyclic stretch induces inducible nitric oxide synthase and soluble guanylate cyclase in pulmonary artery smooth muscle cells. AU - Shah, Monica R.. AU - Wedgwood, Stephen. AU - Czech, Lyubov. AU - Kim, Gina A.. AU - Lakshminrusimha, Satyanarayana. AU - Schumacker, Paul T.. AU - Steinhorn, Robin H. AU - Farrow, Kathryn N.. PY - 2013/2. Y1 - 2013/2. N2 - In the pulmonary vasculature, mechanical forces such as cyclic stretch induce changes in vascular signaling, tone and remodeling. Nitric oxide is a potent regulator of soluble guanylate cyclase (sGC), which drives cGMP production, causing vasorelaxation. Pulmonary artery smooth muscle cells (PASMCs) express inducible nitric oxide synthase (iNOS), and while iNOS expression increases during late gestation, little is known about how cyclic stretch impacts this pathway. In this study, PASMC were subjected to cyclic stretch of 20% amplitude and frequency of 1 Hz for 24 h and compared to control cells maintained under static conditions. ...
Nitric oxide (NO), which is known to inhibit systemic vascular smooth muscle cell proliferation, is used in the management of neonatal pulmonary hypertension. Our objectives were to determine: (1) if endogenous NO production by neonatal porcine pulmonary artery smooth muscle cells (PASMCs) varied with oxygen tension in vitro, and (2) the effect of exogenous NO and inducible NO synthase (iNOS) stimulators and inhibitors on PASMC proliferation and apoptosis. PASMCs were exposed to different conditions (varying PO2, NO donors and scavengers, iNOS stimulators and inhibitors) and proliferation, apoptosis, and cyclic guanosine 5-monophosphate (cGMP) assessed. PASMCs proliferated best between 5 and 10% O2 but cGMP levels were similar at all oxygen levels. NO donors (S-nitroso-N-acetyl-penicillamine, NOC-12, NOC-18) inhibited PASMC proliferation in a dose-dependent manner with associated cGMP increases, while NO scavengers (carboxy-PTIO), iNOS stimulators (interleukin-1β, lipopolysaccharide), and iNOS ...
BACKGROUND: Pulmonary hypertension may complicate human immunodeficiency virus (HIV) infection and result in right ventricular (RV) failure and premature death. There are limited data of the effects of childhood HIV infection or antiretroviral therapy (ART) on pulmonary artery pressure (PAP). OBJECTIVES: To establish if there is an association between childhood ... read more HIV infection or its treatment and pulmonary artery pressure. METHODS: The study conducted a cross-sectional study of 102 HIV-infected (48 ART-naïve, 54 ART-exposed) and 51 HIV-uninfected children in Jakarta, Indonesia, to estimate PAP using echocardiography parameters: tricuspid regurgitation peak velocity (TRV), left ventricular systolic index and diastolic eccentricity index (EI), and RV systolic function, assessed by tricuspid annulus plane systolic excursion. The association between either ART-naive or ART-exposed HIV and PAP was explored using general linear modelling adjusted for potential confounders. RESULTS: ...
The results of this study demonstrate that in unoperated infants with TOF/PA, transthoracic echocardiography can be used to differentiate between patients with and without APCs. Specifically, branch pulmonary artery diameter Z score ≤−2.5, PDA diameter ≤2 mm, and evidence of APCs by color Doppler flow mapping were each sensitive and specific tests with an area under the ROC curve ranging from 0.92 to 0.97. The test performance of transthoracic echocardiography further improved when a branch pulmonary artery diameter Z score ≤−2.5 or PDA diameter ≤2 mm were combined, yielding 97% sensitivity and 100% specificity.. The concept that branch pulmonary artery diameter is inversely related to the extent of APCs in TOF/PA has been previously demonstrated in an autopsy study (12). Acherman et al. (11)demonstrated that patients having a PDA had larger branch pulmonary arteries than patients having no PDA and that the main sources of pulmonary blood flow in this disease can be determined by ...
1. The mechanical and pharmacological properties of small pulmonary arteries (100-300 μm normalized lumen diameter) were directly compared with those of the left main pulmonary artery (1-2 mm) from the rat. The active and passive length-tension characteristics and responses to a variety of agonists and antagonists were dependent on arterial diameter.. 2. Maximum contractile function was obtained in both groups of vessels when stretched so as to give an equivalent transmural pressure of 30 mmHg. This is substantially lower than that found for systemic vessels, and reflects the normal low pulmonary arterial pressure.. 3. Noradrenaline was a powerful vasoconstrictor in large but not small pulmonary arteries (P, 0.001). In contrast, bradykinin produced a significantly greater response in the small arteries (P , 0.001). In comparison with large pulmonary arteries, small arteries were more sensitive to noradrenaline (P,0.05) and 5-hydroxytryptamine (P , 0.001), less sensitive to endothelin-1 (P, ...
Exposure to perinatal hypoxia results in alteration of the adult pulmonary circulation, which is linked among others to alterations in K(+) channels in pulmonary artery (PA) smooth muscle cells. In particular, large conductance Ca(2+)-activated K(+) (BK(Ca)) channels protein expression and activity were increased in adult PA from mice born in hypoxia compared with controls. We evaluated long-term effects of perinatal hypoxia on the cyclic adenosine monophosphate (cAMP)/protein kinase A (PKA) pathway-mediated activation of BK(Ca) channels, using isoproterenol, forskolin, and dibutyryl-cAMP. Whole-cell outward current was higher in pulmonary artery smooth muscle cells from mice born in hypoxia compared with controls. Spontaneous transient outward currents, representative of BK(Ca) activity, were present in a greater proportion in pulmonary artery smooth muscle cells of mice born in hypoxia than in controls. Agonists induced a greater relaxation in PA of mice born in hypoxia compared with controls, and BK
Our previous studies suggested that enhanced pulmonary artery contractions to arachidonic acid in females compared with males were mediated by an LO metabolite.6 The purpose of the current study was to systematically characterize the LO pathways in female and male pulmonary arteries. First, it was shown that the protein expression of both 15- and 5-LO was greater in females compared with males. Although pulmonary arteries from both male and females produced the corresponding LO metabolites, 15- and 5-HETE, only the synthesis of 15-HETE was enhanced in females. The increase in 15-HETE was correlated with an increased 15-HETE-mediated pulmonary artery vasoconstriction in females compared with males. These findings are significant because it is the first report that the 15-LO pathway is regulated in a sex-specific way. These results may impact what is known about the sex differences in the incidence of PAH.. The enhanced vasoconstriction in females compared with males could be because of increased ...
In open-chest dogs, the greater and lesser circulations were perfused by a system of pumps and oxygenator. All blood was drained from the right heart and from the left atrium. in most experiments, there was no dissection around the pulmonary hila, the aorta, or the pulmonary artery. A 30-ml. balloon (Foley catheter) was inserted into the pulmonary artery through a stab wound in the wall of the right ventricle. Pressures were recorded in the pulmonary-artery balloon and in a femoral artery. In other experiments, the main pulmonary artery was distended with blood at known pressures after hydraulic isolation with ligatures and snares.. When the main pulmonary artery was distended proximal to its bifurcation, constriction of the systemic arteries occurred. This phenomenon was abolished by local anesthesia of the wall of the main pulmonary artery, by interrupting conduction in the vagi, by a sympatholytic drug, and by reflex systemic hypotension elicited by multiple small pulmonary emboli. The ...
Human pulmonary artery endothelial cells cryopreserved at passage 3. The endothelial cells express von Willebrand factor and are negative for alpha smooth muscle actin. Axol pulmonary artery endothelial cells can be passaged more than 4 times in Artery Endothelial Cell Culture Medium (ax3810). ...
TY - JOUR. T1 - Unilateral pulmonary artery thromboembolic occlusion in patients. T2 - Is distal arteriopathy a consequence?. AU - Hirsch, A.. AU - Moser, K. M.. AU - Auger, W. R.. AU - Channick, R. N.. AU - Fedullo, P. F.. PY - 1996/1/1. Y1 - 1996/1/1. N2 - The characteristics and post-operative outcomes of eleven patients with total unilateral (UNI)pulmonary artery (PA) thromboembolic occlusion were compared with those of some 600 patients who underwent bilateral (BI) thromboendarterectomies during the same time period. METHODS: Pre-operative historical, physical and laboratory features and post-operative outcomes of these two groups were analyzed. RESULTS: The UNI group had no distinct historical features; however, they were younger (32± 10 years) than the BI group (57 ± 15) and dominantly female (10/11) versus a male predominance (62%) in the BI group. A small lung by chest X-Ray was common (7/11) in the UNI group. Pre-operatively, significantly lower PA mean pressures (30± 12 vs 46 ± 12 ...
Pulmonary arterial hypertension. Pulmonary arterial hypertension (PAH) is a rare form of high blood pressure. It occurs in the pulmonary arteries, which flow from your heart and throughout your lungs. Constricted and narrowed arteries prevent your heart from pumping adequate blood.. How the Main Pulmonary Artery Delivers Blood to the Lungs. The right pulmonary artery carries blood to the right lung while the left pulmonary artery carries it to the left lung. The pulmonary arteries are unique in that unlike most arteries which carry oxygenated blood to other parts of the body, the pulmonary arteries carry de-oxygenated blood…. The specific role of the pulmonary arteries is to carry blood thats low in oxygen and high in carbon dioxide waste to the pulmonary capillaries of the lungs, where this exchange takes place. When the blood is enriched with oxygen and cleared of carbon dioxide waste, it flows back through your pulmonary veins to your hearts right ventricle.. Pulmonary Arteries Diagram - ...
Exposure to hypoxia leads to the development of pulmonary hypertension (PH) as a consequence of pulmonary smooth mus-cle hyperplasia. Hypoxia concomitantly stimulates lung expres-sion of angiogenic factors. To investigate the role of angiogenesis processes in development of hypoxic PH, we examined the effects of lung overexpression of angiostatin, an angiogenesis inhibitor, on development of hypoxic PH and lung endothelial cell (EC) density. Angiostatin delivery was achieved by a defective adeno-virus expressing a secretable angiostatin K3 molcule driven by the cytomegalovirus promoter (Ad.K3). Comparison was made with a control vector containing no gene in the expression cassette (Ad.CO1). Treatment with Ad.K3 (300 plaque-forming units [pfu]/cell) inhibited cultured human pulmonary artery EC migration by 100% and proliferation by 50%, but was without effects on human pulmonary artery smooth muscle cells. After intratracheal administration of Ad.K3 (10 9 pfu) to mice, angios-tatin protein became
Doppler echocardiography was used to evaluate blood flow in the pulmonary artery in 14 patients 2 to 42 months (mean (SD) 17 (12) months) after a modified Fontan operation incorporating a direct atriopulmonary anastomosis. Preoperatively six patients had tricuspid atresia, six had a double inlet left ventricle, and two had pulmonary atresia with an intact ventricular septum. The postoperative rhythm was sinus in 11 patients, junctional in one, ventricular pacing in one, and atrioventricular sequential pacing in one. In one patient the Doppler trace was unsatisfactory for analysis. In all patients forward flow in the pulmonary artery had biphasic peaks related to both atrial and ventricular contraction. The mean (SD) peak flow velocity that was synchronous with atrial contraction was 80 (30) cm/s and that synchronous with ventricular contraction was 74 (23) cm/s. The atrial contribution to total pulmonary artery flow, assessed by velocity-time integrals, varied between 22% and 73% (mean (SD) 45 ...
20-HETE is pro-proliferative, -inflammatory, and -migratory (49, 66), all of which contribute to the pathogenesis of systemic and pulmonary hypertension. Although the increase in 20-HETE by hypoxia inhibited acute hypoxia-induced pulmonary artery constriction (2, 69), it time and dose dependently increased superoxide production from NADPH oxidases in the cultured pulmonary artery endothelial cells (37). Also, studies have reported that 20-HETE-induced superoxide mediated flow-induced constriction of cerebral arteries (58). Our current results further demonstrated that inhibition of 20-HETE biosynthesis by DDMS decreased mitochondrial superoxide generation and conversely application of 20-HETE to endothelium denuded pulmonary arteries for 12 h elicited superoxide generation from mitochondria but not from extra-mitochondrial sources. This led us to the question of how does 20-HETE increase mitochondrial superoxide generation? One potential explanation was 20-HETE passed through the gap junctions ...
The clinical entity of unilateral pulmonary artery absence or hypoplasia can be readily diagnosed on the basis of routine clinical evaluation. This report is based upon 5 patients in whom the diagnosis was suspected and eventually confirmed with the aid of special studies. Characteristic hemodynamic findings were demonstrated by means of cardiac catheterization and contrast visualization of the cardiopulmonary system.. ...
Culture of Pulmonary Arterial Endothelial Cells from Pulmonary Artery Catheter Balloon Tips: Considerations for Use in Pulmonary Vascular Disease The authors cultured pulmonary artery endothelial cells (PAECs) from pulmonary artery catheter balloons used during right heart catheterization, to characterize successful culture attempts and to describe PAEC behavior. [Eur Respir J] Abstract Lymphatic Endothelial Cells Prime Naïve CD8+ T Cells into Memory Cells under Steady-State Conditions Researchers showed that while many proliferating lymphatic endothelial cell-educated T cells entered early apoptosis, the remainders comprised a long-lived memory subset, with transcriptional, metabolic, and phenotypic features of central memory and stem cell-like memory T cells. [Nat Commun] Full Article Endothelial ZEB1 Promotes Angiogenesis-Dependent Bone Formation and Reverses Osteoporosis Investigators showed that the zinc-finger transcription factor ZEB1 was predominantly expressed in CD31hiendomucinhi ...
A complete solution to propagate pulmonary artery endothelial cells in low serum conditions with or without the addition of human recombinant VEGF.
In this study we have shown that patients with COPD receiving LTOT tolerate invasive haemodynamic assessment, including ambulatory PAP monitoring, and can safely perform cardiopulmonary exercise testing at a low workload. The number of patients presented is small because of difficulties encountered in recruiting frail patients in respiratory failure for invasive haemodynamic monitoring but, nevertheless, we found significant changes in haemodynamics.. Previous studies of PAP in patients with COPD have shown that values are modestly increased and progression slow.8 However, most of these measurements have been of resting pressure which has been shown to be of relatively poor prognostic value.9 Furthermore, it has also been shown that even routine daily activities in patients with mild COPD and normal resting oxygen saturations are associated with reductions in oxygen saturation.5. In this study we have measured PAP in a variety of situations in patients with respiratory failure receiving LTOT and ...
Continuous or intermittent hypobaric hypoxia can lead to long-term contraction of the pulmonary artery and structural changes in the pulmonary vascular wall known as hypoxic pulmonary vessel remodelling (HPVR) [20]. HPVR is characterised by thickening of small pulmonary artery wall and muscularizing of pulmonary arteriole, which can result in sustained high pulmonary artery pressure and right ventricular hypertrophy [21]. It has become clear that pulmonary vascular smooth muscle cells (PASMCs) are closely related to the development of pulmonary hypertension, which are regulated by intracellular Ca2+ concentrations and calmodulin (CaM) [1]. The intracellular Ca2+ concentration has also been suggested to regulate gene expression and cellular proliferation [2, 6, 22-25]. Intracellular calcium levels in PASMCs are mainly regulated by extracellular calcium influx and the release of intracellular calcium stores. Chelation of extracellular calcium in human PASMCs can significantly inhibit serum or ...
Intrauterine growth retardation (IUGR) is associated with the development of adult-onset diseases, including pulmonary hypertension. However, the underlying mechanism of the early nutritional insult that results in pulmonary vascular dysfunction later in life is not fully understood. Here, we investigated the role of tyrosine phosphorylation of voltage-gated potassium channel 1.5 (Kv1.5) in this prenatal event that results in exaggerated adult vascular dysfunction. A rat model of chronic hypoxia (2 weeks of hypoxia at 12 weeks old) following IUGR was used to investigate the physiological and structural effect of intrauterine malnutrition on the pulmonary artery by evaluating pulmonary artery systolic pressure and vascular diameter in male rats. Kv1.5 expression and tyrosine phosphorylation in pulmonary artery smooth muscle cells (PASMCs) were determined. We found that IUGR increased mean pulmonary artery pressure and resulted in thicker pulmonary artery smooth muscle layer in 14-week-old rats ...
Genistein, a Soy Phytoestrogen, Reverses Severe Pulmonary Hypertension and Prevents Right Heart Failure in Rats - Hypertension. 2012 Jul 2 - PH was induced in male rats by 60 mg/kg of monocrotaline. After 21 days, when PH was well established, rats received daily injection of genistein (1 mg/kg per day) for 10 days or were left untreated to develop RHF by day 30. Effects of genistein on human pulmonary artery smooth muscle cell and endothelial cell proliferation and neonatal rat ventricular myocyte hypertrophy were assessed in vitro. Severe PH was evident 21 days after monocrotaline, as peak systolic right ventricular pressure increased to 66.35+/-1.03 mm Hg and right ventricular ejection fraction reduced to 41.99+/-1.27%. PH progressed to RHF by day 30 (right ventricular pressure, 72.41+/-1.87 mm Hg; RV ejection fraction, 29.25+/-0.88%), and mortality was ≈75% in RHF rats. Genistein therapy resulted in significant improvement in lung and heart function as right ventricular pressure was ...
Mouse Pulmonary Vein Vascular Smooth Muscle Cells from Creative Bioarray are isolated from tissue of pathogen-free laboratory mice. Mouse Pulmonary Vein Vascular Smooth Muscle Cells are grown in T25 tissue culture flasks pre-coated with gelatin-based solution for 0.5 hour and incubated in Creative Bioarrays Cell Culture Medium generally for 3-7 days. Cultures are then expanded. Prior to shipping, cells are detached from flasks and immediately cryo-preserved in vials. Each vial contains at least 1x10^6 cells per ml and is delivered frozen ...
Figure 1: Relaxation of bovine pulmonary arteries under basal conditions. A: Representative tracing. Endothelium deprived artery strip (detector) was precontracted with 10-5 M histamine (HA). In the upper panel significant relaxation was induced by perfusing the detector with effluent of an endothelium intact pulmonary artery (generator) which was collected and stored prior to perfusion for five minutes (CE). Following direct superfusion (G), additional relaxation was induced. In control experiments (lower panel) only direct superfusion (G) was performed; W = wash. B: Average relaxation. Data shown as mean +/- SEM ...
A complete solution to propagate pulmonary artery endothelial cells in low serum conditions with or without the addition of human recombinant VEGF.
A term infant, born by caesarean section for fetal distress, developed grunting and cyanosis by 15 minutes of age. Ventilation at low pressures was achieved without difficulty but did not improve blood gas levels, and he died at 26 hours. Necropsy examination showed large heart and small lungs; histologically the lungs showed multiple obstructive lesions at medium size pulmonary artery level.. ...
Browsing Research Articles (Cardiothoracic Surgery) by Title Aneurysm of a peripheral pulmonary artery : case report and brief review of the literature ...
Small, muscular pulmonary arteries (PAs) constrict within seconds of the onset of alveolar hypoxia, diverting blood flow to better-ventilated lobes, thereby matching ventilation to perfusion and optimizing systemic PO2. This hypoxic pulmonary vasoconstriction (HPV) is enhanced by endothelial derived vasoconstrictors, such as endothelin, and inhibited by endothelial derived nitric oxide. However, the essence of the response is intrinsic to PA smooth muscle cells in resistance arteries (PASMCs). HPV is initiated by inhibition of the Kv channels in PASMCs which set the membrane potential (EM). It is currently uncertain whether this reflects an initial inhibitory effect of hypoxia on the K+ channels or an initial release of intracellular Ca2+, which then inhibits K+ channels. In either scenario, the resulting depolarization activates L-type, voltage gated Ca2+ channels, which raises cytosolic calcium levels [Ca2+]i and causes vasoconstriction. Nine families of Kv channels are recognized from cloning ...
The pulmonary vasculature comprises a complex network of branching arteries and veins all functioning to reoxygenate the blood for circulation around the body. The cell types of the pulmonary artery are able to respond to changes in oxygen tension in order to match ventilation to perfusion. Stem and progenitor cells in the pulmonary vasculature are also involved, be it in angiogenesis, endothelial dysfunction or formation of vascular lesions. Stem and progenitor cells may be circulating around the body, residing in the pulmonary artery wall or stimulated for release from a central niche like the bone marrow and home to the pulmonary vasculature along a chemotactic gradient. There may currently be some controversy over the pathogenic versus therapeutic roles of stem and progenitor cells and, indeed, it is likely both chains of evidence are correct due to the specific influence of the immediate environmental niche a progenitor cell may be in. Due to their great plasticity and a lack of specific markers
Perfusion scintigraphy demonstrated large bilateral perfusion defects, and the MR angiogram showed significant stenoses of the proximal portions of both pulmonary arteries (figure 1B, D). The coronal CT image highlighted narrowing of the left pulmonary artery secondary to the large mass-like perihilar lesions of PMF (arrow, figure 1C). There was no evidence of large airway obstruction secondary to these lesions.. On right heart catheterisation there was evidence of pulmonary hypertension (PH) with a mean pulmonary artery pressure of 39 mm Hg and a moderate elevation of pulmonary vascular resistance (6 Wood units). The pulmonary capillary wedge pressure (4 mm Hg), right atrial pressure (3 mm Hg) and cardiac index (3.26 L/min/m2) were in the normal range. There was a wide pulmonary artery pulse pressure (83/16 mm Hg), consistent with proximal rather than distal involvement of the pulmonary vasculature. A diagnosis of PH secondary to bilateral central pulmonary artery stenoses was made.. The ...
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The early phases of PAH are considered to be histologically nonspecific, with medial pulmonary arterial and adventitial thickening and the appearance of muscle in the walls of normally nonmuscular arteries being the only abnormalities.20 Many current screening modalities depend on detecting an increase in pulmonary arterial pressure, and thus the early stages of pulmonary vascular disease are likely to be overlooked.21 One mechanism of vascular remodeling is VSMC proliferation.20 We previously reported that sLR11 is a biomarker of VSMC proliferation in atherosclerosis.11,13,15 That prospective study of a small cohort of naive patients uncovered a relationship between sLR11 and mean pulmonary arterial pressure or pulmonary vascular resistance. Levels of sLR11 were significantly increased in patients with, rather than without, PAH. Serum sLR11 levels were 7.8±1.6 ng/mL in 56 healthy volunteers (data not shown). These levels significantly differed between healthy volunteers and patients with PAH ...
Gross Appearance The right ventricle and pulmonary arteries are opened to show a fresh, coiled thromboembolus in the ventricle and in the main, left, and right pulmonary arteries. No infarcts were found in the lungs.. Because this cause of death is usually not suspected, standard autopsy procedure includes exploring the proximal pulmonary arteries for emboli immediately after the chest is opened so as not to displace possible emboli. ...
TY - JOUR. T1 - Original Research. T2 - Role of phosphodiesterases in modulation of BK Ca channels in hypertensive pulmonary arterial smooth muscle. AU - Zhu, Shu. AU - White, Richard E.. AU - Barman, Scott A. PY - 2008/1/1. Y1 - 2008/1/1. N2 - BK Ca channels regulate pulmonary arterial pressure, and protein kinase C (PKC) inhibits BK Ca channels, but little is known about PKC-mediated modulation of BK Ca channel activity in pulmonary arterial smooth muscle. Studies were carried out to determine mechanisms of PKC modulation of BK Ca channel activity in pulmonary arterial smooth muscle cells (PASMC) of the fawn-hooded rat (FHR), an animal model of pulmonary hypertension. Forskolin opened BK Ca channels in FHR PASMC, which was blocked by PKC activation, and reversed by the phosphodiesterase (PDE) inhibitors IBMX, milrinone, and zaprinast. PDE inhibition also blocked the vasoconstrictor response to PKC activation in FHR pulmonary arteries. These results indicate that PKC inhibits cAMP-induced ...
Imatinib is an anti-proliferative agent that was originally designed to inhibit the oncogenic Bcr-abl tyrosine kinase in patients with chronic myeloid leukaemia [41]. Imatinib also has an inhibitory effect on platelet-derived growth factor and c-KIT signalling. These compounds are both important in vascular smooth muscle cell proliferation and hyperplasia and have been implicated in the development of PH [42-44].. Imatinib has been shown to reverse pulmonary vascular disease in animal models of PAH [45], and has been shown to have in vitro anti-proliferative and pro-apoptotic effects on pulmonary artery smooth muscle cells taken from patients with PAH [46].. An initial case study reported the effects of imatinib in a patient with PAH classified as New York Heart Association (NYHA) functional class IV, whose condition was deteriorating despite receiving combination therapy with oral bosentan, inhaled iloprost and sildenafil (but who refused intravenous prostacyclin therapy) [47]. Treatment with ...
Tetrahydrobiopterin (BH4) is an essential cofactor for eNOS. Sepiapterin (Sep) is converted into BH4 by the salvage pathway. BH4 is labile at physiological pH and easily oxidized to BH3 or BH2, making it useless as a cofactor for eNOS dependent •NO generation. Loss of BH4, whether through increased oxidation or impaired synthesis, has been linked to pulmonary hypertension. Previously we showed that NADPH oxidase derived superoxide (O2•−) impaired angiogenesis of Pulmonary Artery Endothelial Cells (PAEC) isolated from in utero pulmonary hypertension fetal lambs (HTFL). As increased NADPH oxidase activity has been linked to oxidation of BH4 and in turn, impaired eNOS activity, we hypothesized that restoring BH4 with Sep might improve PAEC function isolated from HTFL. To test this hypothesis we supplemented PAEC isolated from normotensive fetal lambs and HTFL with Sep (30 μM) and then examined its effects on angiogenesis. Angiogenesis was quantified with respect to tube length, cell ...
Discontinuity of central intrapericardial pulmonary arteries requires reconstruction of a pulmonary artery confluence before cavopulmonary connection, whether this connection be by bidirectional Glenn or Fontan procedure. Reconstruction of the centra
Endothelium-derived relaxing factor (EDRF) is supposed to be identical to nitric oxide (NO). A characteristic of NO is its half-life of 6-50 seconds. We report here bioassay experiments suggesting the presence of a long-acting EDRF. An endothelium intact segment of the main bovine pulmonary artery (generator) and an endothelium deprived artery strip (detector) were seperately perfused with Krebs-Henseleit solution. The effluent of the generator was collected and permitted to stand in an open beaker at 37 °C for periods exceeding five minutes. Following this the collected effluent (CE) perfused the histamine precontracted detector, causing significant relaxation. The same degree of relaxation could be observed after storing CE for 80-120 minutes. After reaching steady state generator effluent (G) was directly superfused over the detector (time delay about two seconds) resulting in a more pronounced relaxation. Addition of pharmacological stimuli of EDRF mediated relaxation augmented, addition of ...
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Pulmonary hypertension (PH) is a disease which manifests itself in the lungs of both adults and children. Vascular proliferation and remodeling are the hallmarks of PH and are found mainly in the pulmonary arterial smooth muscle cells (PASMC). The cause of PASMC proliferation and vascular remodeling in PH is poorly understood. Hypoxia, or low oxygen content, underlies many forms of PH. Hypoxia results in alterations in the redox balance of the PASMC. Therefore, the aim of this study was to examine the role of the thioredoxin system, an antioxidant system in the cell, in hypoxia-induced proliferation in PASMC. Protein was isolated from human PASMC which were exposed to either hypoxia (1% O2, 5% CO2, balance N2) or normoxia (21% O2, 5% CO2 and balance N2) to determine the protein levels of thioredoxin 1 and 2 (Trx1 and Trx2), thioredoxin reductase (TrxR), and thioredoxin interacting protein (Txnip), by Western blotting. Proliferation studies were also done by seeding 6 well plates with 10,000 PASMC
Sudden death due to massive pulmonary embolism is a relatively common autopsy finding, and the medical literature is replete with studies of cases in this category. However, chronic thrombosis of the main pulmonary artery or of the right or left main branches is, in contrast, a rare finding and reported cases are limited in number. As one descends the pulmonary arterial tree, thrombosis becomes more common, depending upon the diligence with which prosection is done. Certainly lobular thrombosis is seen more frequently than lobar and, in turn, arteriolar thrombosis is far more common than either.. A total of 11,511 consecutive ...
NIH Rare Diseases : 50 unilateral absence of the pulmonary artery (uapa) is a heart defect that is present from birth. the pulmonary artery takes blood from the heart to the lungs. in the absence of a pulmonary artery, other blood vessels compensate by supplying blood to the lungs. pressure can build inside these vessels and lead to heart and lung complications. uapa can be left sided or right sided. it most often occurs alone, but can occur with other heart anomalies and birth defects. signs and symptoms include repeat lung infections, lower exercise tolerance, shortness of breath, chest pain, and fluid in the lungs. risk for these symptoms increase with age. complications of uapa include, hemoptysis (coughing up blood), respiratory hemorrhage, and high blood pressure in the arteries to the lung (pulmonary hypertension). serious complications may be triggered by stress on the body, such as pregnancy and altitude sickness. last updated: 2/26/2014 ...
TY - JOUR. T1 - Pulmonary vascular effects of prostaglandin D2, but not its systemic vascular or airway effects, are mediated through thromboxane receptor activation. AU - King, L. S.. AU - Fukushima, M.. AU - Banerjee, M.. AU - Kang, Kyung Ho. AU - Newman, J. H.. AU - Biaggioni, I.. PY - 1991/1/1. Y1 - 1991/1/1. N2 - Prostaglandin D2 (PGD2) can cause pulmonary vasoconstriction or vasodilation depending on animal species and age. Because the constrictor effects of PGD2 in some vascular beds may be mediated through thromboxane receptors, the purpose of this study was to determine whether the vascular or bronchial effects of PGD2 are mediated through thromboxane/endoperoxide (TX/E) receptor activation. In chronically instrumented awake sheep, PGD2 (5-25 μg/kg i.v.) produced a dose-dependent increase in pulmonary arterial pressure and in systemic arterial blood pressure. These changes were due to increases in resistance, because cardiac output remained unchanged. PGD2 also decreased dynamic ...
Pulmonary arterial hypertension (PAH) is a rare, progressive disorder characterized by high blood pressure (hypertension) in the arteries of the lungs (pulmonary artery) for no apparent reason. The pulmonary arteries are the blood vessels that carry bloo
The extraction and analysis of the pulmonary artery in computed tomography (CT) of the chest can be an important, but time-consuming step for the diagnosis and treatment of lung disease, in particular in non-contrast data, where the pulmonary artery has low contrast and frequently merges with adjacent tissue of similar intensity. We here present a new method for the automatic segmentation of the pulmonary artery based on an adaptive model, Hough and Euclidean distance transforms, and spline fitting, which works equally well on non-contrast and contrast enhanced data. An evaluation on 40 patient data sets and a comparison to manual segmentations in terms of Jaccard index, sensitivity, specificity, and minimum mean distance shows its overall robustness ...
TY - JOUR. T1 - Pulmonary artery sling. T2 - Primary repair by tracheal resection in infancy. AU - Jonas, R. A.. AU - Spevak, P. J.. AU - McGill, T.. AU - Castaneda, A. R.. PY - 1989. Y1 - 1989. N2 - Two case reports illustrate a new technique of tracheal resection for primary one-stage correction of pulmonary artery sling. This allows both for removal of the stenotic tracheal segment and for left pulmonary arteriopexy without need for vascular anastomosis.. AB - Two case reports illustrate a new technique of tracheal resection for primary one-stage correction of pulmonary artery sling. This allows both for removal of the stenotic tracheal segment and for left pulmonary arteriopexy without need for vascular anastomosis.. UR - http://www.scopus.com/inward/record.url?scp=0024598336&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=0024598336&partnerID=8YFLogxK. U2 - 10.1016/s0022-5223(19)34545-3. DO - 10.1016/s0022-5223(19)34545-3. M3 - Article. C2 - 2486055. AN - ...
TY - JOUR. T1 - Effects of hypercapnia and hypocapnia on [Ca2+]i mobilization in human pulmonary artery endothelial cells. AU - Nishio, Kazumi. AU - Suzuki, Yukio. AU - Takeshita, Kei. AU - Aoki, Takuya. AU - Kudo, Hiroyasu. AU - Sato, Nagato. AU - Naoki, Katsuhiko. AU - Miyao, Naoki. AU - Ishii, Makoto. AU - Yamaguchi, Kazuhiro. PY - 2001/6. Y1 - 2001/6. N2 - The hydrogen ion is an important factor in the alteration of vascular tone in pulmonary circulation. Endothelial cells modulate vascular tone by producing vasoactive substances such as prostacyclin (PGI2) through a process depending on intracellular Ca2+ concentration ([Ca2+]i). We studied the influence of CO2-related pH changes on [Ca2+]i and PGI2 production in human pulmonary artery endothelial cells (HPAECs). Hypercapnic acidosis appreciably increased [Ca2+]i from 112 ± 24 to 157 ± 38 nmol/l. Intracellular acidification at a normal extracellular pH increased [Ca2+]i comparable to that observed during hypercapnic acidosis. The ...
TY - JOUR. T1 - Clinical determinants of elevated systolic pulmonary artery pressure measured by transthoracic Doppler echocardiography in early systemic sclerosis. AU - EUSTAR co-authors. AU - Carreira, Patricia E.. AU - Carmona, Loreto. AU - Joven, Beatriz E.. AU - Loza, Estibaliz. AU - Andreu, José Luis. AU - Riemekasten, Gabriela. AU - Vettori, Serena. AU - Allanore, Yannick. AU - Balbir-Gurman, Alexandra. AU - Airò, Paolo. AU - Walker, Ulrich A.. AU - Damjanov, Nemanja. AU - Ananieva, Lidia P.. AU - Rednic, Simona. AU - Czirják, L.. AU - Distler, Oliver. AU - Farge, Dominique. AU - Hesselstrand, Roger. AU - Corrado, Ada. AU - Caramaschi, Paola. AU - Tikly, Mohammed. AU - Matucci-Cerinic, Marco. PY - 2017/1/1. Y1 - 2017/1/1. N2 - Objective. To explore the prevalence and clinical associations of elevated systolic pulmonary artery pressure (sPAP), measured by Transthoracic Dopplerechocardiography (TTE) in patients with early systemic sclerosis (SSc). Methods. A cross-sectional analysis of ...
Isolated unilateral absence of the right pulmonary artery without any intracardiac anomaly is a rare congenital cardiovascular disorder. We performed a successful surgical reconstruction with autologous tissue of this anomaly. The patient was a 1-month-old boy who had been transferred to our center at 3 days of age because of tachypnea and heart murmur. Multi-detector CT and radial angiography imaging revealed isolated unilateral absence of the right pulmonary artery and left patent ductus arteriosus. Conservative treatment did not help his progressive heart failure and pulmonary hypertension due to an acute increase of pulmonary blood flow. Therefore surgical correction was determined to avoid the worsening of those symptoms. Under cardiopulmonary bypass, the right pulmonary artery branching off from the brachiocephalic artery was removed and anastomosed to the main pulmonary artery with an autologous pericardium roll. Symptoms improved postoperatively and he was discharged in good condition on ...
TY - JOUR. T1 - Pulmonary artery rupture induced by a pulmonary artery catheter. T2 - A case report and review of the literature. AU - Abreu, Alexandre. AU - Campos, Michael A. AU - Krieger, Bruce P.. PY - 2004/9/1. Y1 - 2004/9/1. N2 - Placement and use of pulmonary artery catheters (PACs) carry potential risks. The authors describe a case of a patient who developed massive hemoptysis after placement of a PAC that caused a rupture of the pulmonary artery with pseudoaneurysm formation. Treatment was successfully achieved with transcatheter coil embolization. Pulmonary artery rupture and pseudoaneurysm formation are among the most serious complications of PAC use because of the associated risk of mortality. Patients with this complication may be asymptomatic or may present with variable amounts of hemoptysis immediately or days after using a PAC. The gold standard diagnostic test is pulmonary angiography, and the treatment of choice for most patients is transcatheter embolization. Physicians and ...
Find link is a tool written by Edward Betts.. searching for Pulmonary artery sling 1 found (4 total). alternate case: pulmonary artery sling. Acute severe asthma (1,007 words) [view diff] case mismatch in snippet view article find links to article ...
TY - JOUR. T1 - A fractal continuum model of the pulmonary arterial tree. AU - Krenz, G. S.. AU - Linehan, J. H.. AU - Dawson, C. A.. PY - 1992. Y1 - 1992. N2 - The extant morphometric data from the intrapulmonary arteries of dog, human, and cat lungs produce graphs of the log of the vessel number, (N) or length (l) in each level vs. the log of the mean diameter (D) in each level that are sufficiently linear to suggest that a scale-independent self-similar or fractal structure may underlie the observed relationships.. AB - The extant morphometric data from the intrapulmonary arteries of dog, human, and cat lungs produce graphs of the log of the vessel number, (N) or length (l) in each level vs. the log of the mean diameter (D) in each level that are sufficiently linear to suggest that a scale-independent self-similar or fractal structure may underlie the observed relationships.. KW - compliance. KW - hemodynamics. KW - inertance. KW - resistance. UR - ...
Anomalous left coronary artery from the pulmonary artery: Find the most comprehensive real-world symptom and treatment data on ALCAPA at PatientsLikeMe. 7 patients with ALCAPA experience fatigue, insomnia, depressed mood, pain, and anxious mood.
Anomalous left coronary artery from the pulmonary artery (ALCAPA), also known as Bland-White-Garland syndrome (BWG), is a rare congenital coronary artery anomaly and is considered one of the most severe of such anomalies. There are two forms, ba...
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Learn more about anomalous left coronary artery from the pulmonary artery (ALCAPA) in children and how Boston Childrens Hospital can help.
Fingerprint Dive into the research topics of Multimodal imaging of anomalous left coronary artery from the pulmonary artery in a 75-year-old woman. Together they form a unique fingerprint. ...
Learn more about Anomalous Left Coronary Artery from the Pulmonary Artery -- Child at Doctors Hospital of Augusta DefinitionCausesRisk FactorsSymptomsDiagnosisTreatmentPreventionrevision ...
Learn more about Anomalous Left Coronary Artery from the Pulmonary Artery -- Child at TriStar Southern Hills DefinitionCausesRisk FactorsSymptomsDiagnosisTreatmentPreventionrevision ...
TY - JOUR. T1 - Right pulmonary artery to left atrial fistula in a neonate: case report and review of the literature. AU - Mongé, M. C.. AU - Russell, H. M.. AU - Popescu, A. M.. AU - Robinson, J. D.. PY - 2014/4. Y1 - 2014/4. N2 - A communication between the right pulmonary artery (RPA) and the left atrium is a rare congenital anomaly that presents with cyanosis and heart failure. We describe the surgical repair of an RPA to left atrial fistula using cardiopulmonary bypass in a neonate. Advanced imaging (computed tomography scan) guided the surgical approach. Although previous reports have associated a patent ductus arteriosus with high neonatal mortality, in our case, the ductus arteriosus was actually important for maintaining enough total pulmonary blood flow.. AB - A communication between the right pulmonary artery (RPA) and the left atrium is a rare congenital anomaly that presents with cyanosis and heart failure. We describe the surgical repair of an RPA to left atrial fistula using ...
OBJECTIVE Significant and balanced pulmonary artery (PA) growth following arterial duct (AD) stenting has already been reported in literature. However, no data are so far available about the role of this percutaneous approach in promoting PA growth in the case of congenital heart disease (CHD) with completely duct-dependent pulmonary blood flow (CDD-PBF). Aim of this study was to evaluate the effect of AD stenting in this pathophysiological setting. METHODS PA growth was evaluated as Nakata index and McGoon ratio as well as individual PA z-score changes in 49 patients submitted to neonatal AD stenting according to their pathophysiology (CDD-PBF (n=15) versus multiple PBF sources (n=34)). RESULTS Control angiography was performed 7.2±6.4 months (range 1-8, median 6) after AD stenting. In the whole population, significant and balanced PA growth was recorded (Nakata index+122±117%; left pulmonary artery (LPA) z-score +84±52%; right pulmonary artery (RPA) z-score +92±53% versus preprocedure, p|0
Unilateral pulmonary artery agenesis is a rare congenital anomaly often associated with other cardiovascular abnormalities. It is usually diagnosed and surgically treated in childhood. Subjects without associated cardiac anomalies (isolated unilatera
TY - JOUR. T1 - Successful extracorporeal circulatory support after aorticreimplantation of anomalous left coronary artery. AU - Alexi-Meskishvili, V.. AU - Hetzer, R.. AU - Weng, Y.. AU - Loebe, M.. AU - Lange, P. E.. AU - Ishino, K.. PY - 1994/10. Y1 - 1994/10. N2 - The development of severe heart failure is the main cause ofpostoperative mortality after the surgical treatment of anomalous origin ofthe left coronary artery from the pulmonary artery (ALCAPA). Two patientswith ALCAPA who developed low cardiac output and could not be weaned fromcardiopulmonary bypass (CPB) after aortic reimplantation of the anomalousleft coronary artery were successfully treated with a centrifugal leftventricular assist device (LVAD) and extracorporeal membrane oxygenation(ECMO). The circulation of a 10-month-old infant with severe leftventricular dysfunction was supported 192 h postoperatively with a LVAD anda 9-year-old boy with severe right ventricular failure received ECMOsupport for 99 h following surgery. ...
TY - JOUR. T1 - A comparison of noninvasive MRI-based methods of estimating pulmonary artery pressure in pulmonary hypertension. AU - Roeleveld, Roald J. AU - Marcus, J Tim. AU - Boonstra, Anco. AU - Postmus, Pieter E. AU - Marques, Koen M. AU - Bronzwaer, Jean G F. AU - Vonk-Noordegraaf, Anton. PY - 2005/7. Y1 - 2005/7. N2 - PURPOSE: To assess the accuracy of several noninvasive MRI-based estimators of pulmonary artery pressure by comparing them with invasive pressure measurement.MATERIALS AND METHODS: We compared five MRI methods with invasive pressure measurement by catheterization, in one group of pulmonary hypertension (PH) patients. Doppler echocardiography was included as a reference method. Main inclusion criterion was a mean pulmonary artery pressure above 25 mmHg at catheterization. MRI velocity quantification was used to obtain pulmonary flow acceleration and ejection times, and pulse wave velocity. The ventricular mass index was also assessed on MRI. Two commercially available 1.5-T ...
We report clinical, CT, invasive coronary angiography and intra-operative findings of a symptomatic elderly man with anomalous origin of left coronary artery from pulmonary artery (ALCAPA). ALCAPA is a rare syndrome with anomalous origin of left main coronary artery (LMCA) from main pulmonary artery (MPA). Survival into adulthood is rare and our case is probably the oldest survivor who has undergone two coronary system repairs for this anomaly. The unique features of our case include: 1) Absence of
TY - JOUR. T1 - Pulmonary artery rupture as a complication of pulmonary hypertension. T2 - Report of a case and review of the literature. AU - Reagin, K. B.. AU - Tazelaar, Henry D.. AU - Edwards, William D.. PY - 1997/5. Y1 - 1997/5. N2 - A 57-year-old woman with severe thromboembolic pulmonary hypertension died suddenly, approximately 3 hours after pulmonary angiography. Autopsy revealed a hemopericardium (350 mL) due to rupture of the pulmonary artery. Three acute partial intimal-medial tears also were observed. Fatal rupture of the mediastinal pulmonary arteries is a rare complication of severe pulmonary hypertension. A review of eight similar cases indicates that rupture tends to occur in patients with systemic levels of pressure, thrombotic (rather than plexogenic) forms of pulmonary hypertension, and survival longer than two years (mean, 4.5 years) from diagnosis.. AB - A 57-year-old woman with severe thromboembolic pulmonary hypertension died suddenly, approximately 3 hours after ...
Pulmonary artery hypertension (PAH) is a female dominant, fatal disease characterized by progressive increase of pulmonary vascular resistance and loss of compliance. The role of estrogen in these pulmonary vascular changes with PAH progression remains unclear. Our objective was to study the effects of estrogen on pulmonary arterial (PA) remodeling in a mouse model of progressive PAH, created via a combination of a VEGF inhibitor Sugen and chronic hypoxia (SuHx). To quantify PA hemodynamics, we measured in vivo pressure and flow simultaneously in live mice in order to obtain pulmonary vascular impedance, a comprehensive measure of RV afterload. Our results demonstrate that estrogen modifies the relationship between PA resistance and compliance by attenuating PA stiffening, which provides insight into sex differences in PAH progression. ...
A method and apparatus for determining right heart ejection fraction by injecting a cold indicator into the right ventricle or locations in the heart upstream thereof during an injection period and allowing the indicator to be diluted with blood and flow to the pulmonary artery whereby the temperature of the fluid in the pulmonary artery falls and then rises, measuring the temperature of the fluid in the pulmonary artery at least during the time that the temperature in the pulmonary artery is rising, measuring a prebolus temperature of the blood in the pulmonary artery prior to the time that the cold indicator reaches the pulmonary artery, establishing a post bolus baseline temperature which is lower than said prebolus baseline temperature, comparing at least some of the measured temperatures during the time that the temperatures of the fluid in the pulmonary artery are rising to the post bolus baseline temperature to establish temperature differentials, and using at least some of the temperature
TY - JOUR. T1 - Wandering bullet embolizing to the pulmonary artery. T2 - A case report. AU - Agarwal, Surendra K.. AU - Singh, Amrendra. AU - Kathuria, Manoj. AU - Ghosh, Probal K.. PY - 2007/4. Y1 - 2007/4. N2 - Whilst a missile embolizing to the right side of the heart is a common occurrence, embolization to the pulmonary arteries is rare. We report a case of a bullet entering through the right internal jugular vein to the right ventricle, and then migrating to the left pulmonary artery, and its management. To our knowledge, this is the first reported such case from the Indian subcontinent.. AB - Whilst a missile embolizing to the right side of the heart is a common occurrence, embolization to the pulmonary arteries is rare. We report a case of a bullet entering through the right internal jugular vein to the right ventricle, and then migrating to the left pulmonary artery, and its management. To our knowledge, this is the first reported such case from the Indian subcontinent.. UR - ...
TY - JOUR. T1 - Notch3 signaling promotes the development of pulmonary arterial hypertension. AU - Li, Xiaodong. AU - Zhang, Xiaoxue. AU - Leathers, Robin. AU - Makino, Ayako. AU - Huang, Chengqun. AU - Parsa, Pouria. AU - MacIas, Jesus. AU - Yuan, Jason X.J.. AU - Jamieson, Stuart W.. AU - Thistlethwaite, Patricia A.. PY - 2009/11/1. Y1 - 2009/11/1. N2 - Notch receptor signaling is implicated in controlling smooth muscle cell proliferation and in maintaining smooth muscle cells in an undifferentiated state. Pulmonary arterial hypertension is characterized by excessive vascular resistance, smooth muscle cell proliferation in small pulmonary arteries, leading to elevation of pulmonary vascular resistance, right ventricular failure and death. Here we show that human pulmonary hypertension is characterized by overexpression of NOTCH3 in small pulmonary artery smooth muscle cells and that the severity of disease in humans and rodents correlates with the amount of NOTCH3 protein in the lung. We ...
TY - JOUR. T1 - Feasibility of oxygen sensitive cardiac magnetic resonance of the right ventricle in pulmonary artery hypertension. AU - Raman, Karthigesh Sree. AU - Stokes, Michael. AU - Walls, Angela. AU - Perry, Rebecca. AU - Steele, Peter M.. AU - Burdeniuk, Christine. AU - De Pasquale, Carmine G.. AU - Celermajer, David S.. AU - Selvanayagam, Joseph B.. N1 - This journal is a peer reviewed, open access journal. All content of the journal is published under the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0). All articles published open access will be immediately and permanently free for everyone to read, download, copy and distribute as defined by the applied license.. PY - 2019/10. Y1 - 2019/10. N2 - Background: Progressive right ventricular (RV) dysfunction in pulmonary arterial hypertension (PAH) which is contributed by RV ischemia leads to adverse clinical outcomes. Oxygen-sensitive (OS) cardiovascular magnetic resonance (CMR) has been ...
TY - JOUR. T1 - Anomalous Origin of the Right Coronary Artery from the Pulmonary Artery. T2 - A Systematic Review. AU - Guenther, Timothy M.. AU - Sherazee, Elan A.. AU - Wisneski, Andrew D.. AU - Gustafson, Joshua D.. AU - Wozniak, Curtis J.. AU - Raff, Gary W.. PY - 2020/1/1. Y1 - 2020/1/1. N2 - Background: Anomalous origin of the right coronary artery from the pulmonary artery (ARCAPA) is a rare congenital cardiac lesion that has been diagnosed in both children and adults with symptoms ranging from an asymptomatic murmur to sudden cardiac death. The aim of this review was to characterize published cases of ARCAPA to better understand this rare congenital coronary anomaly. Methods: A systematic review was performed using PubMed, Embase, and Google Scholar for cases of ARCAPA. Keywords searched included: anomalous origin of the right coronary artery from the pulmonary artery and ARCAPA. Results: A total of 223 cases of ARCAPA were identified in 193 case reports. There was a slight male ...
Pulmonary artery sarcoma (PAS) is an extremely rare and highly malignant tumor that originates in the pulmonary artery. The majority of reported cases of PAS are confirmed by pathological examination subsequent to surgery or by autopsy. The present study reports the clinicopathological characteristics and immunohistochemical phenotypes of three cases of PAS, and aims to facilitate the identification of this lethal disease. In the present study, the data from clinical, histopathological and immunohistochemical examinations of three patients with PAS, whose diagnoses were confirmed by surgical biopsy conducted at the Beijing Anzhen Hospital (Beijing, China) between 2008 and 2012, were retrospectively analyzed. The patients (two women and one man; average age, 41.3 years old) presented with dyspnea on exertion. In addition, two of the patients experienced chest tightness, and one patient experienced intermittent syncope. Computed tomography pulmonary angiography revealed that two of the patients ...
Idiopathic pulmonary artery hypertension (IPAH), previously referred to as primary pulmonary hypertension (PPH), is a relatively recently described entity with an unclear etiology. IPAH is a serious syndrome, with significant morbidity and mortality.
Autori: Ginghina C, Popescu BA, Enache R, Ungureanu C, Deleanu D, Platon P. Editorial: Journal of Cardiovascular Medicine, 9 (7), p.747-750, 2008.. Rezumat:. Dilatation of the pulmonary artery may lead to the compression of adjacent structures. Of those, the extrinsic compression of the left main coronary artery is the most worrisome. We present the case of a 48-year-old woman who was diagnosed with pulmonary artery dilatation due to severe, thromboembolic pulmonary hypertension. She also had angina and coronary angiography revealed a 70% ostial stenosis of the left main coronary artery. The presence of this isolated lesion in a young woman without risk factors for atherosclerosis suggests extrinsic compression of the left main coronary artery by the dilated pulmonary artery as the likely mechanism. The patient underwent direct stenting of the left main coronary stenosis with a good result.. Cuvinte cheie: angina, extrinsic compression, pulmonary artery dilatation, stenting, the left main ...
Video articles in JoVE about pulmonary circulation include Induction and Characterization of Pulmonary Hypertension in Mice using the Hypoxia/SU5416 Model, Surgical Placement of Catheters for Long-term Cardiovascular Exercise Testing in Swine, Videomorphometric Analysis of Hypoxic Pulmonary Vasoconstriction of Intra-pulmonary Arteries Using Murine Precision Cut Lung Slices, 2-Vessel Occlusion/Hypotension: A Rat Model of Global Brain Ischemia, Induction of Right Ventricular Failure by Pulmonary Artery Constriction and Evaluation of Right Ventricular Function in Mice, Synthesis, Functionalization, and Characterization of Fusogenic Porous Silicon Nanoparticles for Oligonucleotide Delivery, The Left Pneumonectomy Combined with Monocrotaline or Sugen as a Model of Pulmonary Hypertension in Rats, Induction and Phenotyping of Acute Right Heart Failure in a Large Animal Model of Chronic Thromboembolic Pulmonary Hypertension, Lung microRNA Profiling Across the Estrous Cycle in Ozone-exposed
Pulmonary arterial hypertension (PAH) is a syndrome of dyspnea, fatigue, chest pain and syncope defined by an increase in pulmonary vascular resistance (PVR) of unknown cause. The pathobiology of PAH remains incompletely understood. The gene of the idiopathic form of PAH (IPAH) has been located on chromosome 2, and shown to present mutations of a sequence that encodes for a transforming growth factor receptor, bone morphogenenetic protein receptor 2 (BMPR2). Severe pulmonary hypertension is associated with an increased expression of the angiogenic factor, angiopoietin-1, which shuts off the expression of BMPR1A, a transmembrane protein necessary for BMPR2 signalling, and thereby causes pulmonary artery smooth muscle cell proliferation. Additional biological abnormalities have been identified at all pulmonary arterial wall compartments of PAH patients. The endothelium produces an excess of endo-thelin, a potent vasoconstrictor and mitogenic mediator, while synthesis and release of antagonistic ...
Introduction: Anomalous left coronary artery from the pulmonary artery (ALCAPA) is a rare Cardiovascular Disease presented with an incidence of 1:300000 live births. Case Presentation: In this manuscript, four cases of ALCAPA in infancy were described. Two infants were presented with respiratory distress and two with heart a murmur. Their coronary artery was ...
Noninvasive pulmonary artery systolic pressure (PASP) is calculated by summing the right ventricular systolic pressure obtained from Doppler velocity of regurgitant flow through the tricuspid valve and the right atrial (RA) pressure. The RA pressure is generally assumed from different formulas. An accurate KA pressure estimation will add precision to PASP calculation. One of the methods to estimate RA pressure is the inferior vena cava collapsibility index (IVCCI). In 45 patients referred for right heart catheterization, the authors tested a formula for the calculation of PASP based on the estimation of RA pressure from IVCCI and compared this method with two other formulas. ...
BACKGROUND: Since pulmonary artery balloon flotation catheterization was first introduced in 1970, by HJ Swan and W Ganz, it has been widely disseminated as a diagnostic tool without rigorous evaluation of its clinical utility and effectiveness in critically ill patients. A pulmonary artery catheter (PAC) is inserted through a central venous access into the right side of the heart and floated into the pulmonary artery. PAC is used to measure stroke volume, cardiac output, mixed venous oxygen saturation and intracardiac pressures with a variety of additional calculated variables to guide diagnosis and treatment. Complications of the procedure are mainly related to line insertion. Relatively uncommon complications include cardiac arrhythmias, pulmonary haemorrhage and infarct, and associated mortality from balloon tip rupture.. OBJECTIVES: To provide an up-to-date assessment of the effectiveness of a PAC on mortality, length of stay (LOS) in intensive care unit (ICU) and hospital and cost of care ...
Pulmonary arterial hypertension (PAH) is a rare-albeit deadly-disease that affects the arteries of the lung. In PAH, abnormal growth of cells of the vascular media-or the elastic wall-of the pulmonary arteries, called pulmonary arterial smooth muscle cells (PASMCs), results in thickening of the walls. This leads to the narrowing and/or obstruction of small pulmonary arteries, thus causing increased pulmonary vascular resistance and arterial pressure-ultimately leading to right heart failure. Over the years, various drugs have been approved for PAH treatment, but the survival of PAH patients three years after diagnosis still remains at approximately 60%, which is not ideal.. In a recent study published in Frontiers in Bioengineering and Biotechnology, researchers in Japan, including Professor Mitsunobu R. Kano and Dr Aiko Ogawa, found a new way to tackle PAH. They reasoned that to find a solution for PAH, a detailed understanding of the processes involved in this disease is crucial. To this end, ...
Photo: 2020 Mitsunobu R. Kano MedicalXpress.com Pulmonary arterial hypertension (PAH) is a rare--albeit deadly--disease that affects the arteries of the lung. In PAH, abnormal growth of cells of the vascular media--or the elastic wall--of the pulmonary arteries, called pulmonary arterial smooth muscle cells (PASMCs), results in thickening of the walls. This leads to the narrowing and/or obstruction of small pulmonary arteries, thus causing increased pulmonary vascular resistance and arterial pressure--ultimately leading to right heart failure. Over the years, various drugs have been approved for PAH treatment, but the survival of PAH patients three years after diagnosis still remains at approximately 60%, which is not ideal. In a recent study published in Frontiers in Bioengineering and Biotechnology, researchers in Japan, including Professor Mitsunobu R. Kano and Dr. Aiko Ogawa, found a new way to tackle PAH. They reasoned that to find a solution for PAH, a detailed understanding of the processes
Multidrug resistance-associated protein 4 (MRP4, also known as Abcc4) regulates intracellular levels of cAMP and cGMP in arterial SMCs. Here, we report our studies of the role of MRP4 in the development and progression of pulmonary arterial hypertension (PAH), a severe vascular disease characterized by chronically elevated pulmonary artery pressure and accompanied by remodeling of the small pulmonary arteries as a prelude to right heart failure and premature death. MRP4 expression was increased in pulmonary arteries from patients with idiopathic PAH as well as in WT mice exposed to hypoxic conditions. Consistent with a pathogenic role for MRP4 in PAH, WT mice exposed to hypoxia for 3 weeks showed reversal of hypoxic pulmonary hypertension (PH) following oral administration of the MRP4 inhibitor MK571, and Mrp4-/- mice were protected from hypoxic PH. Inhibition of MRP4 in vitro was accompanied by increased intracellular cAMP and cGMP levels and PKA and PKG activities, implicating cyclic ...
The present study was undertaken to determine whether the two ubiquitously expressed Ca(2+)-independent phosphatases PP1 and PP2A regulate Ca(2+)-activated Cl(-) currents (I(Cl(Ca))) elicited by 500 nM [Ca(2+)](i) in rabbit pulmonary artery (PA) myocytes dialyzed with or without 3 mM ATP. Reverse transcription-PCR experiments revealed the expression of PP1alpha, PP1beta/delta, PP1gamma, PP2Aalpha, PP2Abeta, PP2Balpha (calcineurin (CaN) Aalpha), and PP2Bbeta (CaN Abeta) but not PP2Bgamma (CaN Agamma) in rabbit PA. Western blot and immunofluorescence experiments confirmed the presence of all three PP1 isoforms and PP2A. Intracellular dialysis with a peptide inhibitor of calcineurin (CaN-AIP); the non-selective PP1/PP2A inhibitors okadaic acid (0.5, 10, or 30 nM), calyculin A (10 nM), or cantharidin (100 nM); and the selective PP1 inhibitor NIPP-1 (100 pM) potently antagonized the recovery of I(Cl(Ca)) in cells dialyzed with no ATP, whereas the PP2A-selective antagonist fostriecin (30 or 150 nM) was
BioAssay record AID 211903 submitted by ChEMBL: In vitro binding affinity towards Tachykinin receptor 2 using rabbit pulmonary artery tissues.
Pulmonary arterial hypertension (PAH) is a multifactorial cardiopulmonary disease characterized by an elevation of pulmonary artery pressure (PAP) and pulmonary vascular resistance (PVR), which can lead to right ventricular (RV) failure, multi-organ dysfunction, and ultimately to premature death. dysfunction (7). Open in a separate window Figure 1 Pathogenesis of pulmonary hypertension. PAH is associated with vascular and cardiac remodeling. In PAH, vascular remodeling is characterized by smooth muscle and endothelial cell dysfunction. Indeed, both cell types contribute to muscularization, obstruction, and constriction of distal pulmonary arteries (PAs) which progressively increase the vascular resistance to induce right ventricle (RV) hypertrophy and eventually RV dysfunction. Representative photos from the vascular redesigning in pulmonary arterioles have already been previously released by Dr Hadri and collaborators (185). PAH, pulmonary arterial hypertension; Rolapitant cost PASMC, pulmonary ...
en] The acid-sensitive, two-pore domain K(+) channel, TASK-1, contributes to the background K(+) conductance and membrane potential (Em) of rat and human pulmonary artery (PA) smooth muscle cells (SMC), but its role in regulating tone remains elusive. This study aimed to clarify the role of TASK-1 by determining the functional properties of PA from mice in which the TASK-1 gene was deleted (TASK-1/3 KO), in comparison with wild type (WT) C57BL/6 controls. Small vessel wire myography was used to measure isometric tension developed by intact PA. Em and currents were recorded from freshly isolated PASMC using the perforated patch-clamp technique. Reverse-transcription polymerase chain reaction (RT-PCR) was used to estimate K(+) channel expression. We could find no difference between PA from WT and TASK-1/3 KO TASK KO mice. They showed similar constrictor responses to a range of agonists and K(+) concentrations, the K(+) channel blockers 4-aminopyridine, tetraethylammonuim ions and XE991. ...
Hemodynamic data were collected from both the right and left heart catheterization. Pressure tracings were recorded on a recorder (Hewlett-Packard 4568C) with fluid-filled catheters. Left ventricular angiograms were obtained in the standard 30° right anterior oblique projection and the ejection fraction was calculated using the single plane method of Dodge. Significant CAD was defined as a 70 percent or greater luminal diameter narrowing of at least one of the following major vessels: the left anterior descending, the left circumflex (or large marginal branch), and the right coronary artery. Left main coronary disease was considered to be present when a 50 percent or greater narrowing was visualized, and these patients were assigned triple-vessel disease for the overall statistical analysis. All other vessels were considered normal. The angiograms were read as part of the clinical practice of the institution and not under controlled conditions. Pulmonary vascular resistance was calculated as ...
Pulmonary pressure[edit]. Main article: Pulmonary artery pressure. Normally, the pressure in the pulmonary artery is about 15 ... The rise in pulse pressure with age is attributed to increased stiffness of the arteries.[32] An age-related rise in blood ... Baroreceptors in low pressure receptor zones (mainly in the venae cavae and the pulmonary veins, and in the atria) result in ... What Is Pulmonary Hypertension? From Diseases and Conditions Index (DCI). National Heart, Lung, and Blood Institute. Last ...
... pulmonary valve → (pulmonary artery and pulmonary circulation) ... valve and pumps it into the pulmonary artery via the pulmonary ... Its upper and left angle forms a conical pouch, the conus arteriosus, from which the pulmonary artery arises. A tendinous band ... pulmonary veins) → left atrium (atrial appendage) → mitral valve → left ventricle → aortic valve (aortic sinus) → (aorta and ... The extra pressure exerted is also needed to stretch the aorta and other arteries to accommodate the increase in blood volume. ...
The smaller arteries and arterioles have higher resistance, and confer the main blood pressure drop across major arteries to ... In the innominate artery, the average reading is 110/70 mmHg, the right subclavian artery averages 120/80 and the abdominal ... The shear stress at the wall that is associated with blood flow through an artery depends on the artery size and geometry and ... Other major arteries have similar levels of blood pressure recordings indicating very low disparities among major arteries. ...
The radial artery is the easiest to use to check the heart rate. However, in emergency situations the most reliable arteries to ... including pulmonary vessels and the right side of the heart itself. Rates of firing from the baroreceptors represent blood ... This pulse rate can be found at any point on the body where the artery's pulsation is transmitted to the surface by pressuring ... Fox K, Ford I (2008). "Heart rate as a prognostic risk factor in patients with coronary artery disease and left-ventricular ...
Biosense-Webster, a subsidiary of Johnson & Johnson, produces a cardiac electrophysiology system called CARTO.[4] The system is designed to visualise the real-time calculated position and orientation of a specialised RF ablation catheter within the patient's heart in order to minimise radiation exposure during fluoroscopy, increase the accuracy of targeted RF ablation and reacquisition of pacing sites for re-ablation.[5] Its navigation system calculates the position and orientation of the catheter tip, using three known magnetic sources as references. The system uses static magnetic fields that are calibrated and computer controlled. Due to the nature of magnetic fields, the orientation may also be calculated while the tip is stationary. By calculating the strength and orientation of the magnetic fields at a given location, the x,y,z position may be calculated along with the roll, pitch, yaw orientation.[4] ...
... including coronary artery disease, cerebrovascular disease, peripheral artery disease, and many other conditions. ... pulmonary gas pressures. *alveolar gas equation. *alveolar-arterial gradient. *hemoglobin. *oxygen-haemoglobin dissociation ... For example, hypoperfusion can be caused when an artery or arteriole that supplies blood to a volume of tissue becomes blocked ...
"The U wave is the momentum carried by the blood in the coronary arteries and blood vessels".[4][5][6] ... The U wave is the momentum carried by the blood in the coronary arteries and blood vessels. It is possible to take this ... "Exercise-induced U-wave inversion as a marker of stenosis of the left anterior descending coronary artery". Circulation. 60 (5 ... and especially appears to have a high positive predictive accuracy for left anterior descending coronary artery disease[7] ) or ...
... provide pulmonary circulation by pulsing oxygen-depleted blood through the pulmonary valve then through the pulmonary arteries ... and below those in the trunks of the aorta and pulmonary arteries, the aortic and pulmonary valves close again-see, at right ... one to the pulmonary artery and one to the aorta. Notably, near the end of the "Diastole", the atria begin contracting, then ... exceeding the pressures in the trunks of the aorta and the pulmonary arteries and causing the requisite valves (the aortic and ...
atrium to pulmonary artery Fontan procedure. left ventricle to aorta Rastelli procedure. right ventricle to pulmonary artery ... systemic circulation to pulmonary artery shunt Blalock-Taussig shunt. SVC to the right PA Glenn procedure. ... Bypass/Coronary artery bypass MIDCAB. Off-pump CAB. TECAB. Coronary stent. Bare-metal stent. Drug-eluting stent. *Bentall ... Suspected pulmonary embolism or shortness of breath. *A third heart sound, fourth heart sound, a cardiac murmur[11] or other ...
The pulmonary artery wedge pressure (also called pulmonary artery occlusion pressure or PAOP) is a measurement in which one of ... displaystyle {\frac {80\cdot (mean\ pulmonary\ arterial\ pressure-mean\ pulmonary\ artery\ wedge\ pressure)}{cardiac\ output}}} ... Pulmonary Artery Catheters" *^ a b c d e GB Thurston, Viscosity and viscoelasticity of blood in small diameter tubes, ... Pulmonary calculations[edit]. The pulmonary vascular resistance can be calculated in units of dyn·s·cm−5 as ...
... in particular the large arteries and small arterioles. The process is the opposite of vasodilation, the widening of blood ...
pulmonary circulation. 100% (deoxygenated). Vasoconstriction in response to hypoxia cerebral circulation. 15%[2]. high. under- ... Blood flow through the left coronary artery is at a maximum during diastole (in contrast to the rest of systemic circulation, ...
Renin levels are high in the fetus, while angiotensin II levels are significantly lower; this is due to the limited pulmonary ... blood flow, preventing ACE (found predominantly in the pulmonary circulation) from having its maximum effect. ...
Pulmonary. Right heart → Pulmonary arteries → Lungs → Pulmonary vein → Left heart. Microanatomy. *Microvessel ... Left heart → Aorta → Arteries → Arterioles → Capillaries → Venules → Veins → Vena cava → (Right heart) ... Contribution of vasomotion to vascular resistance: a comparison of arteries from virgin and pregnant rats. J Appl Physiol. 1998 ...
Artery. Aorta,[a] pulmonary trunk and right and left pulmonary arteries,[b] right coronary artery, left main coronary artery[c] ... The pulmonary trunk branches into the left and right pulmonary arteries that carry the blood to each lung. The pulmonary valve ... The pulmonary trunk divides into pulmonary arteries and progressively smaller arteries throughout the lungs, until it reaches ... The pulmonary valve is located at the base of the pulmonary artery. This has three cusps which are not attached to any ...
In electrocardiography, during a cardiac cycle, once an action potential is initiated, there is a period of time that a new action potential cannot be initiated. This is termed the effective refractory period (ERP) of the tissue. This period is approximately equal to the absolute refractory period (ARP), it occurs because the fast sodium channels remain closed until the cell fully repolarizes. During this period, depolarization on adjacent cardiac muscles does not produce a new depolarization in the current cell as it has to refract back to phase 4 of the action potential before a new action potential can activate it. ERP acts as a protective mechanism and keeps the heart rate in check and prevents arrhythmias, and it helps coordinates muscle contraction. Anti-arrhythmic agents used for arrhythmias usually prolong the ERP. For the treatment of atrial fibrillation, it is a problem that the prolongation of the ERP by these agents also affects the ventricles, which can induce other types of ...
Peaked P waves (, 0.25 mV) suggest right atrial enlargement, cor pulmonale, (P pulmonale rhythm),[1] but have a low predictive value (~20%).[2] A P wave with increased amplitude can indicate hypokalemia.[3] It can also indicate right atrial enlargement.[4] A P wave with decreased amplitude can indicate hyperkalemia. Bifid P waves (known as P mitrale) indicate left-atrial abnormality - e.g. dilatation [5] or hypertrophy.[1] If at least three different shaped P waves can be seen in a given ECG lead tracing, this implies that even if one of them arises from the SA node, at least two others are arising elsewhere. This is taken as evidence of multiple (i.e. at least two) ectopic foci, and is called multifocal (or more correctly, multiform) atrial rhythm if the rate is ≤100) or multifocal atrial tachycardia if the rate is over 100.[6] This appears particularly commonly in exacerbations of chronic obstructive lung disease.[7] If the baseline has a totally irregular form, this suggests fibrillatory ...
pulmonary artery hypertension Latanoprost. PGF2α analog. Glaucoma, ocular hypertension. Misoprostol. PGE1 analog. stomach ... Pulmonary hypertension, avoiding reperfusion injury Bimatoprost. PGF2α analog. Glaucoma, ocular hypertension. Carboprost. PGF2α ... PGI2 analogs used to treat vascular disorders like pulmonary hypertension, Raynaud's syndrome, and Buerger's disease[60][61][62 ... "Comparative Safety and Tolerability of Prostacyclins in Pulmonary Hypertension". Drug Safety. 39 (4): 287-94. doi:10.1007/ ...
... cavities and ground glass lesions are common in patients with pulmonary involvement.[9] Pulmonary artery thrombosis may occur. ... and in severe cases can be life-threatening if the outlet pulmonary artery develops an aneurysm which ruptures causing severe ...
"Pulmonary Artery Wedge Pressure • LITFL • CCC Equipment". Life in the Fast Lane • LITFL • Medical Blog. 2019-01-04. Retrieved ... Pulmonary wedge pressure will overestimate left ventricle pressure in people with mitral valve stenosis, pulmonary hypertension ... "CV Physiology , Pulmonary Capillary Wedge Pressure". www.cvphysiology.com. Retrieved 2019-10-06. "Pulmonary: Heart Failure". ... When both the heart and lungs are healthy, pulmonary wedge pressure is equal to left ventricle diastolic pressure and can be ...
... pulmonary valve → (pulmonary artery and pulmonary circulation) ... Surrounds heart and bases of pulmonary artery and aorta.. *Deep ... pulmonary veins) → left atrium (atrial appendage) → mitral valve → left ventricle → aortic valve (aortic sinus) → (aorta and ... This happens at two areas: where the aorta and pulmonary trunk leave the heart and where the superior vena cava, inferior vena ... cava and pulmonary veins enter the heart.[4] In between the parietal and visceral pericardial layers there is a potential space ...
Transverse section of thorax, showing relations of pulmonary artery. *. Diagram of the course and branches of a typical ...
Transverse section of thorax, showing relations of pulmonary artery. External links[edit]. *Internal thoracic vein - ... Bilaterally, it arises from the superior epigastric vein, accompanies the internal thoracic artery along its course and ...
Pulmonary artery aneurysms are rare. Historically, pulmonary artery aneurysms were believed to be a common cause of hemoptysis ... the actual bronchial bleeding may be from the bronchial artery, rather than from the pulmonary artery.[medical citation needed ... Rasmussen's aneurysm is a pulmonary artery aneurysm associated with a cavitary lung lesion. It was originally described by ... "Aneurysms of the Pulmonary Arteries". Chest. 94 (5): 1065-1075. doi:10.1378/chest.94.5.1065. PMID 3053058. v t e. ...
... knowledge of the pulmonary artery catheter. Pulmonary Artery Catheter Study Group". JAMA. 264 (22): 2928-32. doi:10.1001/jama. ... The pulmonary artery catheter (PAC) introduced to clinical practice in 1970, also known as the Swan-Ganz catheter, provides ... The average velocity in a vessel, i.e., the aorta or the pulmonary artery, is quantified by measuring the average signal ... Phillips RA, Hood SG, Jacobson BM, West MJ, Wan L, May CN (2012). "Pulmonary Artery Catheter (PAC) Accuracy and Efficacy ...
Nodules, consolidations, cavities and ground glass lesions are common in patients with pulmonary involvement. Pulmonary artery ... and in severe cases can be life-threatening if the outlet pulmonary artery develops an aneurysm which ruptures causing severe ... ElGuindy MS, ElGuindy AM (October 2017). "Aneurysmal coronary artery disease: An overview". Global Cardiology Science and ... Although infrequent, myocardial infarction (heart attack) with angiographically identified acute coronary artery thrombosis has ...
Caval filter migrated to heart or pulmonary artery (4 patients). Numerous small published articles and case studies report ... The main function of a vena cava filter is to prevent death from massive pulmonary emboli. Long-term clinical follow-up studies ... Olin, JW; Young JR; Graor RA; Ruschhaupt WF; Beven EG; Bay JW (1987). "Treatment of deep-vein thrombosis and pulmonary emboli ... These are patients that should strongly consider having IVC filter placement, as they are at greatest risk of pulmonary embolus ...
Pulmonary artery catheterization should be considered. Hypotension should be treated preferentially with fluids, but systemic ... Pulmonary edema and pulmonary infections are commonly seen in patients with ALF. Mechanical ventilation may be required. ... Pulmonary complications occur in up to 50% of patients. Severe lung injury and hypoxemia result in high mortality. Most cases ... Pulmonary haemorrhage, pleural effusions, atelectasis, and intrapulmonary shunts also contribute to respiratory difficulty. In ...
Flores, RM (Feb 2011). "Reply to difference in outcome in the transection of the pulmonary artery and vein". The Journal of ... Garcia, A; Byrne, JG; Bueno, R; Flores, RM (Dec 2008). "Aneurysm of the main pulmonary artery". Annals of Thoracic and ...
... systolic pressure of the pulmonary artery; mean pressure of the pulmonary artery (only required of sarcoidosis patients); ... cystic fibrosis Pulmonary Fibrosis, etc.); age of the patient; body mass index; presence or absence of diabetes mellitus; ... pulmonary capillary wedge pressure (PCW pressure); flow rate of supplemental oxygen required at rest; distance walked in six ... article on page 7 of the Winter 2007 Pathlight newsletter of the Pulmonary Hypertension Association. Grady, Denise: "Updated ...
More rarely the maxillary or a branch of the external carotid artery can be ligated. The bleeding can also be stopped by intra- ... These blood vessels include the sphenopalatine, anterior and posterior ethmoidal arteries. ... pulmonary embolism *Hampton hump. *Westermark sign. *pulmonary edema *Kerley lines. *Hamman's sign ...
Deoxygenated blood is then pumped by the right ventricle to the lungs via the pulmonary artery which is divided in two branches ... Veins and arteries appear similar when skin is removed and are seen directly.[4][5] ... Blood is oxygenated in the lungs and returns to the left atrium through the pulmonary veins. ...
The worst kind of pulmonary embolism is caused by a saddle embolus. This kind of embolus blocks the pulmonary artery, which ... There are a few treatments for pulmonary embolism. The choice of which treatments to use depends on how serious the pulmonary ... A pulmonary embolism is a clot of material (an embolus) that blocks blood from getting to the lungs. It is usually caused by a ... "Pulmonary Embolism - Risk Factors". www.mayoclinic.org. The Mayo Clinic. March 18, 2015. Retrieved December 31, 2015.. ...
In the hybrid procedure, bilateral pulmonary artery bands are positioned to limit pulmonary flow while, at the same time, ... The atrial septum is removed, the aortic arch is reconstructed to remove any hypoplasia, and then the main pulmonary artery is ...
... pulmonary valve → (pulmonary artery and pulmonary circulation) ... while anteriorly it is hidden by the pulmonary artery and aorta ... pulmonary veins) → left atrium (atrial appendage) → mitral valve → left ventricle → aortic valve (aortic sinus) → (aorta and ...
... as is the case for the pulmonary artery (which delivers de-oxygenated blood from the heart to the lungs) and the arteries that ... each containing deep grooves in the place where one would expect to find the afferent branchial artery. This strongly suggests ... aorta for oxygenated blood and pulmonary vein for deoxygenated blood. The spiral valve is essential to keeping the mixing of ...
Arteries or veins. *Angiopathy *Macroangiopathy. *Microangiopathy. *Embolism *Pulmonary embolism. *Cholesterol embolism. * ... "Edinburgh Artery Study: prevalence of asymptomatic and symptomatic peripheral arterial disease in the general population". Int ... It is classically associated with early-stage peripheral artery disease, and can progress to critical limb ischemia unless ... testing is often performed to confirm the diagnosis of peripheral artery disease. ...
... membranous nephropathy is known to predispose affected individuals to develop blood clots such as pulmonary emboli. Membranous ... Renal artery stenosis. *Renal ischemia. *Hypertensive nephropathy. *Renovascular hypertension. *Renal cortical necrosis ...
Pulmonary artery catheter. *Blood cultures. *Screening cultures. Life-supporting treatments. *Airway management ...
It is therefore used to indicate deep-vein thrombosis, pulmonary embolism, DIC and efficacy of treatment in acute myocardial ... They are given following a heart attack to dissolve the thrombus blocking the coronary artery; experimentally after a stroke to ... allow blood flow back to the affected part of the brain; and in the event of a massive pulmonary embolism. ...
Both of these changes result in increased blood pressure in the pulmonary arteries, which may cause right-sided heart failure ... Wikimedia Commons has media related to Chronic obstructive pulmonary disease.. *Chronic obstructive pulmonary disease at Curlie ... "Chronic obstructive pulmonary disease (COPD)". WHO. Retrieved 5 June 2019. Chronic Obstructive Pulmonary Disease (COPD) is not ... pulmonary rehabilitation appears to improve the overall quality of life and the ability to exercise.[109][110] If pulmonary ...
2008) Trial of prophylactic inhaled steroids to prevent or reduce pulmonary function decline, pulmonary symptoms, and airway ... 2010) Sclerosis therapy of bronchial artery attenuates acute lung injury induced by burn and smoke inhalation injury in ovine ... 2008) Trial of prophylactic inhaled steroids to prevent or reduce pulmonary function decline, pulmonary symptoms, and airway ... 12 h before symptoms of pulmonary edema develop. Acute lung injury (ALI), also called non-cardiogenic pulmonary edema, is ...
Arteries or veins. *Angiopathy *Macroangiopathy. *Microangiopathy. *Embolism *Pulmonary embolism. *Cholesterol embolism. * ... Bilateral renal artery stenosis should always be considered as a differential diagnosis for the presentation of HN. Kidney ... This leads to a build-up of plaques and they can be deposited in the renal arteries causing stenosis and ischemic kidney ... Also, luminal narrowing or the arteries and arterioles of the kidney system. However, this type of procedure is likely to be ...
... including the umbilical arteries and vein. The differential vasoconstriction of these fetal vessels compared to the vasodilator ... forming the ligamentum arteriosum between the pulmonary trunk and aortic arch. It also plays a role in the constriction and ...
Possible consequences include hypertension, heart failure, and pulmonary edema. Hypothermia[edit]. The human body is at risk of ... Surrounding structures such as the pleura and carotid artery are also at risk of damage with the potential for pneumothorax or ... One reason veins are preferred over arteries for intravascular administration is because the flow will pass through the lungs ... even cannulation of the artery. There are several types of central IV access, depending on the route that the catheter takes ...
Eparterial refers to its position above the right pulmonary artery. The right bronchus now passes below the artery, and is ... The azygos vein arches over it from behind; and the right pulmonary artery lies at first below and then in front of it. About 2 ... and has the left pulmonary artery lying at first above, and then in front of it. The left bronchus has no eparterial branch, ... It can have multiple variations and, although usually asymptomatic, it can be the root cause of pulmonary disease such as a ...
Thomas, IT; Smith, DW (June 1974). "Oligohydramnios, cause of the nonrenal features of Potter's syndrome, including pulmonary ... and a single umbilical artery. Presence of a diaphragmatic hernia is also common in these fetuses/infants. Additionally, the ... These infants will eventually die as either a result of pulmonary hypoplasia or renal failure. ... pulmonary hypoplasia and cranial anomalies related to the oligohydramnios.[clarification needed] Oligohydramnios is the ...
He noted that blood clots in the pulmonary artery originate first from venous thrombi, stating in 1859: "[T]he detachment of ... Virchow is also known for elucidating the mechanism of pulmonary thromboembolism (a condition of blood clotting in the blood ... that pulmonary thrombi are transported from the veins of the leg and that the blood has the ability to carry such an object. He ... His autopsy on a baby in 1856 was the first description of congenital pulmonary lymphangiectasia (the name given by K. M. ...
Coronary artery disease (CAD). *Coronary artery aneurysm. *Spontaneous coronary artery dissection (SCAD) ...
2007). "Donepezil for cognitive decline following coronary artery bypass surgery: a pilot randomized controlled trial". ... chronic obstructive pulmonary disease, asthma, severe cardiac arrhythmia and sick sinus syndrome.[15] ... coronary artery bypass surgery cognitive impairment,[32] cognitive impairment associated with multiple sclerosis, CADASIL ...
pulmonary embolism (McConnell's sign). *radial artery sufficiency (Allen's test). *pseudohypertension (Osler's sign) ...
Pulmonary veins attach to the left atrium separately, and also the opening to the pulmonary veins are separated by a septum.[68 ... The morphology for heat exchange occurs via cerebral arteries and the ophthalmic rete, a network of arteries originating from ... The interatrial artery of the ostrich is small in size and exclusively supplies blood to only part of the left auricle and ... The coronary arteries start in the right and left aortic sinus and provide blood to the heart muscle in a similar fashion to ...
... pulmonary artery and pulmonary vein) and therefore is considered the approach of choice for pulmonary resection (pneumonectomy ... When performed over the fifth intercostal space, it allows optimal access to the pulmonary hilum ( ...
The most common cause of sudden death in the US is coronary artery disease. Approximately 300,000 people die suddenly of this ... Atrial fibrillation can also be treated through a procedure, e.g. pulmonary vein isolation. This is performed by a cardiologist ...
L-type calcium channel blockers can induce dilation of the coronary arteries while also decreasing the heart's demand for ... Beta-receptor antagonists should be avoided in patients with reactive pulmonary disease to avoid asthma attacks. Also Beta- ... involves placing a stent at the site of stenosis in an artery and inflating the stent using a balloon catheter. Another ...
Pulmonary artery catheter. *Blood cultures. *Screening cultures. Life-supporting treatments. *Airway management ...
... the pressure in the pulmonary artery will close the pulmonary valve. The closure of the pulmonary valve contributes the P2 ... The pulmonary valve (sometimes referred to as the pulmonic valve) lies between the right ventricle and the pulmonary artery, ... pulmonary valve → (pulmonary artery and pulmonary circulation) ... Pulmonary atresia is the complete closure of the pulmonary ... The two semilunar (SL) valves, the aortic valve and the pulmonary valve, which are in the arteries leaving the heart. ...
Arteries or veins. *Angiopathy *Macroangiopathy. *Microangiopathy. *Embolism *Pulmonary embolism. *Cholesterol embolism. * ... leading to pathologic changes in the small arteries of the kidney. Affected arteries develop endothelial dysfunction and ... The most common clinical presentations of hypertensive emergencies are cerebral infarction (24.5%), pulmonary edema (22.5%), ... Cardiovascular system damage can include myocardial ischemia/infarction, acute left ventricular dysfunction, acute pulmonary ...
... "aorta and pulmonary arteries were filled with air" - a condition called an air embolism which "is almost uniformly fatal".[14] ... "pulmonary injuries similar to that seen in victims of chlorine gas exposure".[7] Apart from the risks of gastric inflation ...
atrium to pulmonary artery Fontan procedure. left ventricle to aorta Rastelli procedure. right ventricle to pulmonary artery ... systemic circulation to pulmonary artery shunt Blalock-Taussig shunt. SVC to the right PA Glenn procedure. ... Bypass/Coronary artery bypass MIDCAB. Off-pump CAB. TECAB. Coronary stent. Bare-metal stent. Drug-eluting stent. *Bentall ...
Pulmonary artery catheters. BMJ 2006; 333 doi: https://doi.org/10.1136/bmj.39028.502882.68 (Published 16 November 2006) Cite ...
Incompetence of the Pulmonary Artery. Br Med J 1894; 2 doi: https://doi.org/10.1136/bmj.2.1749.7 (Published 07 July 1894) Cite ...
Definition of pulmonary artery anastomosis. Provided by Stedmans medical dictionary and Drugs.com. Includes medical terms and ... pulmonary artery anastomosis. Definition: anastomosis of the pulmonary artery; 40-50% are associated with congenital heart ...
The author reports a case of a patient with bilateral pulmonary artery aneurysms, in whom the nature of the lesions was not ... Pulmonary artery aneurysms should be included in the differential diagnosis of lung masses. ... Aneurysms of the pulmonary arteries are rare. The author reports a case of a patient with bilateral pulmonary artery aneurysms ... Massive Hemoptysis from Pulmonary Artery Aneurysms,. Canadian Respiratory Journal,. vol. 9. ,. Article ID 906390. ,. 2. pages ...
... sling is created by anomalous origin of the left pulmonary artery from the posterior aspect of the right pulmonary artery. The ... anomalous left pulmonary artery courses over the right mainstem bronchus and then from right to left, posterior to the trachea ... encoded search term (Pulmonary Artery Sling) and Pulmonary Artery Sling What to Read Next on Medscape. Related Conditions and ... Pulmonary artery sling is a rare defect created by anomalous origin of the left pulmonary artery from the posterior aspect of ...
POSTOPERATIVE DIAGNOSIS: 1. Dysplastic pulmonary valve with mass. 2. Coronary artery disease. 3. Large pulm ... 1. Dysplastic pulmonary valve with mass.. 2. Coronary artery disease.. 3. Large pulmonary artery aneurysm.. PROCEDURES:. 1. ... artery to his LAD.. 2. Pulmonary artery aneurysmorrhaphy/repair.. 3. Pulmonary valve replacement utilizing a 27 millimeter ... I have 33475 and 33533, but cant find a code for the pulmonary artery aneurysm repair. I was thinking 33335 but would like ...
... Anas Nooh,1,2 Fahad H. Abduljabbar,1,2 Ahmed H. Abduljabbar,2,3 and ... Anas Nooh, Fahad H. Abduljabbar, Ahmed H. Abduljabbar, and Peter Jarzem, "Pulmonary Artery Cement Embolism after a ...
The pulmonary arteries take blood from the heart to the lungs. ... The pulmonary arteries take blood from the heart to the lungs. ...
In pulmonary artery hypertension, reduced pulmonary artery compliance is a strong independent predictor of mortality, and ... Recapitulation of developing artery muscularization in pulmonary hypertension.. Sheikh AQ1, Lighthouse JK1, Greif DM2. ... In contrast, poor understanding of distal arteriole muscularization in pulmonary artery hypertension severely limits existing ... We recently demonstrated that embryonic pulmonary artery wall morphogenesis consists of discrete developmentally regulated ...
Double oblique CTA image in the plane of the main and branch pulmonary arteries demonstrates normal caliber pulmonary arteries ... A Problematic Pediatric Pulmonary Artery. Vikram Venkatesh, MD, Manavjot Sidhu MD, Niamh Kilcullen, MD, Ana Maria Rosales, MD, ... Patients with corrected DORV remain at risk for main, segmental, and branch pulmonary artery stenosis, and thus require ongoing ... Figure 1: Color Doppler echocardiography demonstrates the main pulmonary artery bifurcation with turbulent flow. The right was ...
... from primary pulmonary hypertension (PPH) by means of the indexes of pulmonary arterial r... ... OBJECTIVES: The purpose of this investigation was to differentiate chronic pulmonary thromboembolism (CPTE) ... Pulmonary artery reflection for differentially diagnosing primary pulmonary hypertension and chronic pulmonary thromboembolism ... To quantify the pulmonary artery reflection, we used the augmentation index and inflection time. RESULTS: The augmentation ...
Pulmonary artery - Blood vessel that carries oxygen-depleted blood from the right ventricle to the lungs, is clearly explained ... Medical Word - Pulmonary artery. Ans : Blood vessel that carries oxygen-depleted blood from the right ventricle to the lungs. ... Pulmonary artery - Glossary. Written & Compiled by Medindia Content Team. Medically Reviewed by The Medindia Medical Review ...
Pulmonary artery catheterization (PAC), or right heart catheterization, is the insertion of a catheter into a pulmonary artery ... pulmonary artery, and the filling pressure ("wedge" pressure) of the left atrium. The pulmonary artery catheter is frequently ... "Pulmonary artery catheter" - news · newspapers · books · scholar · JSTOR (March 2009) (Learn how and when to remove this ... The standard pulmonary artery catheter has two lumens (Swan-Ganz) and is equipped with an inflatable balloon at the tip, which ...
The left coronary artery (LCA), which carries blood to the heart muscle, begins from the pulmonary artery instead of ... Anomalous left coronary artery from the pulmonary artery (ALCAPA) is a heart defect. ... Anomalous left coronary artery from the pulmonary artery (ALCAPA) is a heart defect. The left coronary artery (LCA), which ... In children with ALCAPA, the LCA originates from the pulmonary artery. The pulmonary artery is the major blood vessel that ...
Clopidogrel in infants with systemic-to-pulmonary-artery shunts.. Wessel DL, Berger F, Li JS, Dähnert I, Rakhit A, Fontecave S ... Infants with cyanotic congenital heart disease palliated with placement of a systemic-to-pulmonary-artery shunt are at risk for ... Clopidogrel therapy in infants with cyanotic congenital heart disease palliated with a systemic-to-pulmonary-artery shunt, most ... randomly assigned infants 92 days of age or younger with cyanotic congenital heart disease and a systemic-to-pulmonary-artery ...
Sugimoto S, Kikuchi S, Oosawa H, Hachiro Y, Takagi N, Abe T. A reoperation for anomalous origin of right pulmonary artery: ... Anomalous origin of a pulmonary artery from the aorta (AOPA), commonly referred to as the "hemitrunus," is a rare congenital ... We recently encountered a 19-month patient with AOPA who had undergone banding of the anomalous right pulmonary artery (RPA) ... Dealing with surgical repair for this anomaly consists of detaching the anomalous pulmonary artery (PA) from the aorta and ...
Public Health Catheter Pulmonary Artery Pulmonary Artery Catheter Thermal Safety These keywords were added by machine and not ...
Pulmonary hypertension is characterized by elevated pulmonary artery pressure and pulmonary artery smooth muscle cell (SMC) ... Pulmonary artery rupture induced by a pulmonary artery catheter: a case report and review of the literature. Alexandre R Abreu ... The mechanism of pulmonary artery smooth muscle cell (PA-SMC) hyperplasia in idiopathic pulmonary artery hypertension (iPH) may ... Remodeling of the pulmonary artery by an inappropriate increase of pulmonary artery smooth muscle cells (PASMCs) is problematic ...
The purpose of the pulmonary artery is to... ... The pulmonary artery is a vital artery connected to the right ... These arise from the pulmonary trunk (sometimes called the main artery) and are called right and left pulmonary arteries. Their ... The pulmonary artery (PA) is a vital and specialized artery connected to the right ventricle of the heart. The name is actually ... Doctors can use methods such as balloon catheterization the pulmonary arteries and prevent pulmonary hypertension.. ...
3 patients with pulmonary artery stenosis experience fatigue, depressed mood, pain, anxious mood, and insomnia. ... Find the most comprehensive real-world symptom and treatment data on pulmonary artery stenosis at PatientsLikeMe. ... What is pulmonary artery stenosis?. The pulmonary artery is the narrowing of a major blood vessel of the heart. This blood ... 0 pulmonary artery stenosis patients report mild anxious mood (0%). * 1 a pulmonary artery stenosis patient reports no anxious ...
Unilateral Pulmonary Artery Absence or Hypoplasia. JOHN C. ELDER, BERNARD L. BROFMAN, PAUL M. KOHN, BERNARD L. CHARMS, Joan ... Unilateral Pulmonary Artery Absence or Hypoplasia. JOHN C. ELDER, BERNARD L. BROFMAN, PAUL M. KOHN, BERNARD L. CHARMS, Joan ... Unilateral Pulmonary Artery Absence or Hypoplasia. Radiographic and Cardiopulmonary Studies in Five Patients. JOHN C. ELDER, ... The clinical entity of unilateral pulmonary artery absence or hypoplasia can be readily diagnosed on the basis of routine ...
... an artery carrying blood from the heart to the lungs can form a sling around the windpipe and block air flow. Learn more about ... When someone has a pulmonary artery sling (PAS), the left pulmonary artery comes out of the right pulmonary artery a short ... left pulmonary artery from the right pulmonary artery and reattach it to the pulmonary artery stem in front of the trachea. ... the pulmonary artery splits in two just after leaving the heart to form the right and left pulmonary arteries. Both arteries ...
Structurally normal heart except for a prominent main pulmonary artery at the level of the origin of the ductus arteriosus. The ... If the pulmonary artery and PDA appear larger and the aortic arch appears smaller, that is a prenatal indicator for possible ... if that looks fine, then the size of the pulmonary artery and PDA do not matter, as long as the flow of blood through them is ... As far as the size of the pulmonary artery and ductus arteriosus are concerned on a fetal echocardiogram, that is not of much ...
Fluorescence emission intensity from a culture of bovine pulmonary artery endothelial cells stained with BODIPY FL phallacidin ... Bovine Pulmonary Artery Cell Actin. B-1E Bandpass Emission (Narrow Bandwidth Excitation) Blue Set. Fluorescence emission ... intensity from a culture of bovine pulmonary artery endothelial cells stained with BODIPY FL phallacidin, which binds to the ...
The previously occult pulmonary artery was found in 10 patients, in five of whom a vestige of an intrapericardial artery was ... a gap existing between the main pulmonary artery and the hilar vessel, and no artery was found in one. All patients with an ... The occult pulmonary artery, where identified at operation, was usually joined initially to the systemic circulation. ... Ultimately, continuity between the hilar and main pulmonary artery may be established surgically. Where no intrapericardial ...
Nemours pediatric heart experts specialize in early detection and repair of Pulmonary Artery Sling, a rare variety of vascular ... If your childs been diagnosed with pulmonary artery sling, were here to ease your concerns, answer your questions, and give ... why Nemours pediatric heart experts specialize in early detection and repair of congenital heart defects like pulmonary artery ...
A complete solution to propagate pulmonary artery endothelial cells in low serum conditions with or without the addition of ... Primary Pulmonary Artery Endothelial Cells; Normal, Human (HPAEC) (ATCC® PCS-100-022™) Organism: Homo sapiens, human / Tissue: ... Primary Pulmonary Artery Smooth Muscle Cells; Normal, Human (PASMC) (ATCC® PCS-100-023™) Add to ... Primary Pulmonary Artery Endothelial Cells; Normal, Human (HPAEC) ATCC® PCS-100-022™ frozen 1 mL ...
Relationship Between Pulmonary Artery Pressure and Catheter Position. LEON STEIN, ARNOLD ABERMAN, JEAN-JACQUES BERAUD ...
Pulmonary artery smooth muscle cells (PASMCs) were dispersed from similar-sized IPAs using collagenase (type XI; 2 mg/mL) and ... Both RhoK and PKC modulate Ca2+ sensitivity in the pulmonary artery,19 but because inhibition of RhoK was without effect, and 1 ... Capacitative calcium entry as a pulmonary specific vasoconstrictor mechanism in small muscular arteries of the rat. Br J ... Low Concentrations of Sphingosylphosphorylcholine Enhance Pulmonary Artery Vasoreactivity. The Role of Protein Kinase Cδ and Ca ...
Unilateral pulmonary artery agenesis is a rare congenital anomaly often associated with other cardiovascular abnormalities. It ... Pulmonary Artery / abnormalities*. Pulmonary Circulation. Recurrence. Respiratory Tract Infections / etiology. From MEDLINE®/ ... Unilateral pulmonary artery agenesis is a rare congenital anomaly often associated with other cardiovascular abnormalities. It ... We report a case of left pulmonary artery agenesis in a 35-year-old man complicated by hemoptysis and treated by pneumonectomy ...
  • Pulmonary artery catheterization ( PAC ), or right heart catheterization , is the insertion of a catheter into a pulmonary artery . (wikipedia.org)
  • The pulmonary artery catheter allows direct, simultaneous measurement of pressures in the right atrium, right ventricle, pulmonary artery, and the filling pressure ( "wedge" pressure ) of the left atrium. (wikipedia.org)
  • The pulmonary artery catheter is frequently referred to as a Swan-Ganz catheter , in honor of its inventors Jeremy Swan and William Ganz , from Cedars-Sinai Medical Center . (wikipedia.org)
  • Justification for its continued use rests on a large body of clinical experience, disadvantages of other cardiac output monitoring systems, its ability to accurately measure pulmonary artery pressure, and the potential to use the catheter as a direct conduit for drug administration into the pulmonary artery. (wikipedia.org)
  • Illustration depicting a catheter on the pulmonary artery. (wikipedia.org)
  • The standard pulmonary artery catheter has two lumens (Swan-Ganz) and is equipped with an inflatable balloon at the tip, which facilitates its placement into the pulmonary artery through the flow of blood. (wikipedia.org)
  • The balloon, when inflated, causes the catheter to "wedge" in a small pulmonary blood vessel. (wikipedia.org)
  • 1 During the last 2 decades, the trend indicates that pulmonary artery (PA) catheterization use decreased by 65% from 5.66 to 1.99 per 1000 medical admissions in the U.S., 2 probably due to growing evidence that this invasive procedure does not reduce mortality, but increases the chances of transient arrhythmias, catheter-related sepsis, and pulmonary-artery injury. (appliedradiology.com)
  • In most cases, the right pulmonary artery is affected, as the inferior right pulmonary artery is the most common location for catheter-tip placement. (appliedradiology.com)
  • It has been stipulated that this results from the inherent curvature of the catheter that favors insertion into the inferior right pulmonary artery. (appliedradiology.com)
  • I think that the tip of my pulmonary artery catheter is displaying a Right Ventricular waveform. (lhsc.on.ca)
  • In this procedure the doctor places a thin, flexible tube (called a Swan-Ganz catheter) usually in the subclavian vein of the patient's upper chest and then threads it into the right ventricle and pulmonary artery. (medmovie.com)
  • Early use of the pulmonary artery catheter and outcomes in patients with shock and acute respiratory distress syndrome: a randomized controlled trial. (medscape.com)
  • Rhodes A, Cusack RJ, Newman PJ, Grounds RM, Bennett ED. A randomised, controlled trial of the pulmonary artery catheter in critically ill patients. (medscape.com)
  • Impact of the pulmonary artery catheter in critically ill patients: meta-analysis of randomized clinical trials. (medscape.com)
  • Pulmonary-artery versus central venous catheter to guide treatment of acute lung injury. (medscape.com)
  • The effect of pulmonary artery catheter use on costs and long-term outcomes of acute lung injury. (medscape.com)
  • Clinical outcomes in patients undergoing elective coronary artery bypass graft surgery with and without utilization of pulmonary artery catheter-generated data. (medscape.com)
  • Lack of effectiveness of the pulmonary artery catheter in cardiac surgery. (medscape.com)
  • This is measured by inserting a catheter into the main pulmonary artery. (wikipedia.org)
  • The diagnosis and treatment of CHF and its episodes of decompensation can be facilitated by pulmonary artery catheter use, but its efficacy is highly dependent on the physician's experience in the treatment of such patients. (clinicaltrials.gov)
  • Migration of a polyethylene catheter to the pulmonary artery has occurred on three occasions within a period of 9 months. (annals.org)
  • Pulmonary artery catheter is an invasive monitor usually placed in high-risk cardiac surgical patients to optimize the cardiac functions. (scielo.br)
  • We present this case of blood oozing from the oximetry connection port of the pulmonary artery catheter that resulted in the inability to monitor continuous cardiac output requiring replacement of the catheter. (scielo.br)
  • Perioperative monitoring with a balloon-tipped, flow-directed, pulmonary artery catheter (PAC) is typically performed in high-risk surgical patients to facilitate optimization of cardiac function. (scielo.br)
  • The complications unique to the insertion and use of this catheter include carotid artery puncture, hematoma, pneumothorax, ventricular arrhythmias, pulmonary artery embolism/rupture, sepsis, catheter entrapment and knotting. (scielo.br)
  • In conclusion, the reported case here is an unusual presentation of the manufacturing defect of the pulmonary artery catheter. (scielo.br)
  • Recapitulation of developing artery muscularization in pulmonary hypertension. (nih.gov)
  • Excess smooth muscle accumulation is a key component of many vascular disorders, including atherosclerosis, restenosis, and pulmonary artery hypertension, but the underlying cell biological processes are not well defined. (nih.gov)
  • In pulmonary artery hypertension, reduced pulmonary artery compliance is a strong independent predictor of mortality, and pathological distal arteriole muscularization contributes to this reduced compliance. (nih.gov)
  • In contrast, poor understanding of distal arteriole muscularization in pulmonary artery hypertension severely limits existing therapies that aim to dilate the pulmonary vasculature but have modest clinical benefit and do not prevent hypermuscularization. (nih.gov)
  • Pulmonary arterial hypertension (PAH) is characterized by enhanced proliferation and reduced apoptosis of pulmonary artery smooth muscle cells (PASMCs). (labome.org)
  • In adults, the most common disease affecting these arteries is pulmonary hypertension . (wisegeek.com)
  • Pulmonary hypertension weakens the right ventricle over time because it must pump harder to feed blood to the lungs. (wisegeek.com)
  • Other times surgery is not even open-heart surgery anymore, and doctors can use things like balloon catheterization to widen the arteries and prevent pulmonary hypertension. (wisegeek.com)
  • DUBLIN--(BUSINESS WIRE )--Jan 22, 2019--The " Pulmonary Arterial Hypertension - Global API Manufacturers, Marketed and Phase III Drugs Landscape , 2019" drug pipelines has been added to ResearchAndMarkets.com's offering. (wn.com)
  • The report provides comprehensive insights about marketed and Phase III products for Pulmonary Arterial Hypertension. (wn.com)
  • Her history was significant for hypertension, atrial fibrillation, pulmonary hypertension, and atrial septal defect repaired 40 years prior. (appliedradiology.com)
  • This case is unique, representing chronic segmental pulmonary artery dissection secondary to cor pulmonale and pulmonary hypertension from a combination of obstructive sleep apnoea and obesity hypoventilation in a living patient. (bmj.com)
  • Pulmonary artery dissection is a serious complication of pulmonary arterial hypertension. (bmj.com)
  • A case is described of chronic segmental pulmonary artery dissection secondary to cor pulmonale and pulmonary hypertension. (bmj.com)
  • Pulmonary artery dissection: an emerging cardiovascular complication in surviving patients with chronic pulmonary hypertension. (bmj.com)
  • It is also used to evaluate primary pulmonary hypertension. (medmovie.com)
  • Pulmonary hypertension occurs alone and as a consequence of a number of lung diseases . (wikidoc.org)
  • A 46-year old woman with a six-month history of progressive exertional dyspnea, moderate tricuspid insufficiency and moderate pulmonary hypertension was admitted to the hospital for further evaluation. (massgeneral.org)
  • In recent years, transgenic mouse models have been developed to examine the underlying cellular and molecular mechanisms of lung disease and pulmonary vascular disease, such as asthma, pulmonary thromboembolic disease, and pulmonary hypertension. (nih.gov)
  • Also consider immunization with palivizumab in infants and young children with idiopathic pulmonary artery hypertension (IPAH). (medscape.com)
  • Go to Primary Pulmonary Hypertension and Persistent Newborn Pulmonary Hypertension for more complete information on these topics. (medscape.com)
  • Pulmonary hypertension is used to describe an increase in the pressure of the pulmonary artery, and may be defined as a mean pulmonary artery pressure of greater than 25mmHg. (wikipedia.org)
  • As can be measured on a CT scan, a diameter of more than 29 mm diameter is often used as a cut-off to indicate pulmonary hypertension. (wikipedia.org)
  • Pulmonary hypertension was defined as pulmonary artery systolic pressure of at least 30 mmHg corresponding to a peak tricuspid regurgitant jet velocity of ≥2.5 m/second. (aappublications.org)
  • Mild pulmonary hypertension was defined as tricuspid regurgitant jet velocity ≥2.5 to 2.9 m/second. (aappublications.org)
  • Moderate pulmonary hypertension was defined as tricuspid regurgitant jet velocity ≥3 m/second. (aappublications.org)
  • Characteristics were compared between patients with mild, moderate, and no pulmonary hypertension using 1-way analysis of variance for continuous variable and Fisher's exact test for categorical variables. (aappublications.org)
  • Pulmonary hypertension (PHT) is a widely recognized complication of hereditary hemolytic anemias including sickle cell disease, 1 - 10 thalassemia, 11 - 13 hereditary spherocytosis, 14 and paroxysmal nocturnal hemoglobinuria. (aappublications.org)
  • Increased blood pressure in the pulmonary artery is referred to as pulmonary hypertension and often is linked to loud pulmonic valve closures. (mdpi.com)
  • For the purpose of this paper, it was hypothesized that pulmonary circulation vibrations will create sounds similar to sounds created by vocal cords during speech and that subjects with pulmonary artery hypertension (PAH) could have unique sound signatures across four auscultatory sites. (mdpi.com)
  • To observe the change in pulmonary artery systolic pressure (PASP) of patients with persistent pulmonary arterial hypertension (PAH) after patent ductus arteriosus (PDA) occlusion. (dovepress.com)
  • Pulmonary hypertension is an abnormal elevation of pressure in the pulmonary circulation that results in stress on the heart and remodeling of blood vessels in the lung. (brightsurf.com)
  • Pulmonary hypertension is caused by a variety of factors, and patient prognosis often depends on the underlying cause. (brightsurf.com)
  • Increased stiffness of pulmonary arteries has been linked to increased mortality in patients with pulmonary hypertension, but it is not clear how stiffness develops or drives worsening of disease. (brightsurf.com)
  • Using very high-resolution microscopy, Frendenburgh and colleagues detected vascular matrix stiffening in early stages of pulmonary hypertension in both humans and experimental animal models. (brightsurf.com)
  • Importantly, in a rat model, treatment with a prostaglandin analog reduced pulmonary arterial stiffening and attenuated pulmonary hypertension. (brightsurf.com)
  • The results of this study reveal pulmonary arterial stiffening as an early driver of pulmonary hypertension. (brightsurf.com)
  • A systematic review of the comparative effectiveness and safety of phosphodiesterase type 5 inhibitors in pediatric patients with pulmonary hypertension published Feb. (brightsurf.com)
  • A groundbreaking study from the University of Pittsburgh and UPMC identifies new compounds that could have robust effects in treating pulmonary hypertension. (brightsurf.com)
  • Pulmonology and genetics experts from two Utah healthcare organizations have collaboratively developed a new diagnostic genomic testing method for a rare form of pulmonary hypertension caused by a genetic mutation they discovered three years ago. (brightsurf.com)
  • Researchers at Baylor College of Medicine who focus on bronchopulmonary dysplasia and pulmonary hypertension, a common lung disease in premature infants, have shown that echocardiography can be used to detect the pulmonary hypertension in neonatal mice at an earlier time point than previously thought. (brightsurf.com)
  • Pulmonary hypertension is a highly lethal disease that transforms the thin, flexible vasculature of the lungs into thick, dysfunctional blood vessels that can kill. (brightsurf.com)
  • Johns Hopkins Medicine researchers report that rising blood levels of a protein called hematoma derived growth factor are linked to the increasing severity of pulmonary arterial hypertension, a form of damaging high blood pressure in the lungs. (brightsurf.com)
  • We report the case of a 45-year-old male under treatment for CPTE associated with pulmonary arterial hypertension and chronic cor pulmonale . (scielo.br)
  • We emphasize the difficulties in diagnosing intimal sarcoma of the pulmonary artery, the need to investigate this neoplasm in the differential diagnosis of CPTE and the systematic use of criteria for the appropriate prescription of new medications for pulmonary artery hypertension. (scielo.br)
  • He reported having been through extensive assessment and having received a diagnosis of CPTE associated with pulmonary hypertension. (scielo.br)
  • Pulmonary arterial hypertension is characterized by elevated pulmonary artery pressure and vascular resistance. (ahajournals.org)
  • Mechanisms to explain the increased incidence of pulmonary hypertension in women are not known. (ahajournals.org)
  • Understanding this novel sex-specific mechanism may provide insight into the increased incidence of pulmonary hypertension in females. (ahajournals.org)
  • Pulmonary arterial hypertension (PAH) encompasses a group of diseases characterized by high pulmonary artery pressure and pulmonary vascular resistance. (ahajournals.org)
  • 3 , 4 These recent studies are important because they suggest that the role of vasoconstriction in late stages of pulmonary hypertension may be underappreciated. (ahajournals.org)
  • We present the case of a 48-year-old woman who was diagnosed with pulmonary artery dilatation due to severe, thromboembolic pulmonary hypertension. (ad-astra.ro)
  • We report the case of a 57-year-old woman treated with furosemide, spironolactone and fluindione for primary pulmonary hypertension. (em-consulte.com)
  • While the seminal advance in the treatment of pulmonary artery hypertension (PAH) over the past 2 decades has been pharmacological targeting of dysfunctional endothelium-derived pathways that contribute to the characteristic vascular remodeling of this condition irrespective of etiology (1) , several novel interventional techniques have also been useful in selected patients. (onlinejacc.org)
  • More recently, balloon angioplasty has shown promise as a treatment for both inoperable Chronic Thromboembolic Pulmonary Hypertension (CTEPH) and for patients in whom the operative risk is deemed to be unacceptably high (3) . (onlinejacc.org)
  • In dogs with pulmonary hypertension induced by monocrotaline, Zhou et al. (onlinejacc.org)
  • Additionally, mRNA expression of cytokines and mediators of pulmonary vasoconstriction and proliferation, which was increased in dogs in which pulmonary hypertension developed after monocrotaline injection, was reduced after PADN. (onlinejacc.org)
  • Additionally, the mean nerve conduction velocity in monocrotaline-treated dogs in which pulmonary hypertension did not develop was midway between the means of controls and animals with monocrotaline PAH, suggesting that in these animals, although hemodynamically normal, pulmonary vascular abnormalities might develop over a more prolonged period of observation. (onlinejacc.org)
  • Recently, nebivolol, a drug that is a β 1 -adrenergic antagonist and a β 2,3 -adrenergic agonist, has been demonstrated to produce beneficial effects in experimental pulmonary hypertension (7) , and Zhou et al. (onlinejacc.org)
  • 1) To date, animal models of pulmonary hypertension have not been predictive of successful therapies for human disease. (onlinejacc.org)
  • Presentation often involves the main pulmonary arteries and pulmonary valves with resultant pulmonary embolism and chronic thromboembolic pulmonary hypertension leading to the misdiagnosis of pulmonary embolic disease. (omicsonline.org)
  • An 84-year-old woman presented with hemoptysis during an elective right-heart catheterization when a pulmonary capillary wedge pressure measurement was performed. (appliedradiology.com)
  • A pulmonary artery pseudoaneurysm should be suspected in patients presenting with radiographic changes, usually hilar enlargement, commonly early within the first week after PA catheterization. (appliedradiology.com)
  • Pulmonary Artery Catheterization (Right Heart Catheterization or sometimes called Swan-Ganz Catheterization) is used to obtain diagnostic information about the heart. (medmovie.com)
  • What is the wave form analysis in the different pathologic states of pulmonary artery catheterization (PAC)? (medscape.com)
  • Evaluation study of congestive heart failure and pulmonary artery catheterization effectiveness: the ESCAPE trial. (medscape.com)
  • What is the role of left ventricular end-diastolic volume (LVEDV) in pulmonary artery catheterization (PAC)? (medscape.com)
  • Acute vasodilator trials in the catheterization laboratory should be performed to determine pulmonary vascular reactivity. (medscape.com)
  • To compare the efficacy of Pulmonary Artery Catheterization (PAC)-directed treatment strategy to a non-invasive treatment strategy on morbidity and mortality in patients with severe, class IV New York Heart Association (NYHA) congestive heart failure. (clinicaltrials.gov)
  • These studies include the present cardio-oncology study, outcomes of femoral artery catheterization in patients with US versus palpation techniques, as well as studying the outcomes of diabetic heart failure patients implanted with CardioMEMS. (omicsonline.org)
  • At the age of 6, he developed a mild stenosis of his left pulmonary artery, a common late complication. (massgeneral.org)
  • Patients with corrected DORV remain at risk for main, segmental, and branch pulmonary artery stenosis, and thus require ongoing surveillance studies. (massgeneral.org)
  • These can include pulmonary stenosis , which means narrowing of a PA, or complete absence or no function of the PAs, called atresia. (wisegeek.com)
  • Through surgery, it is possible to correct stenosis, and sometimes surgery will involve replacement of the artery. (wisegeek.com)
  • When you share what it's like to have pulmonary artery stenosis through your profile, those stories and data appear here too. (patientslikeme.com)
  • Got a question about living with pulmonary artery stenosis? (patientslikeme.com)
  • Who has pulmonary artery stenosis on PatientsLikeMe? (patientslikeme.com)
  • Symptomatic pulmonary artery stenosis is a relatively uncommon manifestation of Takayasu's arteritis. (massgeneral.org)
  • A few studies have shown that percutaneous angioplasty and stent implantation is a safe and effective treatment in patients with pulmonary stenosis caused by Takayasu's arteritis (2,3). (massgeneral.org)
  • Endovascular stent implantation for severe pulmonary artery stenosis in aortoarteritis (Takayasu's arteritis). (massgeneral.org)
  • Qin L, Hong-Liang Z, Zhi-Hong L, Chang-Ming X, Xin-Hai N. Percutaneous transluminal angioplasty and stenting for pulmonary stenosis due to Takayasu's arteritis: clinical outcome and four-year follow-up. (massgeneral.org)
  • For further evaluation, he was referred for computed tomography angiography (CTA) which demonstrated diffuse, long-segment stenosis of the ascending aorta along with significant ostioproximal stenosis of the right brachiocephalic artery and left common carotid artery with diffuse dilatation of the post-ostial segments (Figure 2A-B). (medworm.com)
  • AbstractWilliams syndrome is a genetic disorder associated with various cardiovascular abnormalities, most commonly supravalvar aortic stenosis and peripheral pulmonary stenosis. (medworm.com)
  • Patients with pulmonary stenosis or right outflow obstruction were excluded. (aappublications.org)
  • Apply the diagnostic algorithm for patients with complex pulmonary artery (PA) stenosis and/or major aortopulmonary collateral arteries (MAPCAs). (stanford.edu)
  • This study will first quantify and describe pulmonary artery stenosis in patients with Alagille Syndrome. (clinicaltrials.gov)
  • The investigators hope to learn the degree and characteristics of pulmonary artery stenosis in Alagille Syndrome. (clinicaltrials.gov)
  • The investigators also hope to learn the effect of this pulmonary artery stenosis on the right ventricle in patients with Alagille Syndrome. (clinicaltrials.gov)
  • This information is critical in the management of patients with Alagille syndrome, as there is currently no data to guide clinicians on the management of pulmonary artery stenosis. (clinicaltrials.gov)
  • Furthermore, the information from this study may help physicians manage pulmonary artery stenosis in other patients as well. (clinicaltrials.gov)
  • She also had angina and coronary angiography revealed a 70% ostial stenosis of the left main coronary artery. (ad-astra.ro)
  • Peripheral pulmonary artery stenosis. (bmj.com)
  • Due to the differences in clinical prognosis and subsequent management strategies, in situ PAT associated with RT -- which has not previously been described in the English literature -- must be distinguished from pulmonary embolism. (medworm.com)
  • it also occurs as a consequence of pulmonary embolism and scleroderma . (wikidoc.org)
  • An ECG-gated computed tomography arteriogram (CTA) was negative for pulmonary embolism but demonstrated multifocal areas of smooth concentric narrowing and vessel wall thickening involving the distal right pulmonary artery, right upper lobe pulmonary artery, interlobar pulmonary artery and left main pulmonary artery as well as the left common carotid artery and the left subclavian artery (Figure A and C), consistent with Takayasu's disease. (massgeneral.org)
  • This may occur as a result of heart problems such as heart failure, lung or airway disease such as COPD or scleroderma, or thromboembolic disease such as pulmonary embolism or emboli seen in sickle cell anaemia. (wikipedia.org)
  • Sudden death due to massive pulmonary embolism is a relatively common autopsy finding, and the medical literature is replete with studies of cases in this category. (annals.org)
  • Patients with suspected pulmonary embolism often undergo computed tomography pulmonary angiography to confirm or exclude the diagnosis. (brightsurf.com)
  • A randomized, controlled trial of the use of pulmonary-artery catheters in high-risk surgical patients. (medscape.com)
  • Assessment of the clinical effectiveness of pulmonary artery catheters in management of patients in intensive care (PAC-Man): a randomised controlled trial. (medscape.com)
  • Finally, the study would provide the basis for developing competency requirements for physicians, nurses, and others who insert and use pulmonary artery catheters, which was a strong recommendation of the PACCO Workshop. (clinicaltrials.gov)
  • The left coronary artery (LCA), which carries blood to the heart muscle, begins from the pulmonary artery instead of the aorta. (medlineplus.gov)
  • Anomalous origin of a pulmonary artery from the aorta (AOPA), commonly referred to as the "hemitrunus," is a rare congenital anomaly. (springer.com)
  • Dealing with surgical repair for this anomaly consists of detaching the anomalous pulmonary artery (PA) from the aorta and connecting it to the main or opposite PA. (springer.com)
  • We recently encountered a 19-month patient with AOPA who had undergone banding of the anomalous right pulmonary artery (RPA) from the aorta as a primary palliation in the neonatal period. (springer.com)
  • If the pulmonary artery and PDA appear larger and the aortic arch appears smaller, that is a prenatal indicator for possible development of narrowing in the aorta called coarctation of the aorta after the child's birth. (medhelp.org)
  • These progressively enlarge until the trunk splits into the aorta and pulmonary arteries. (wn.com)
  • The left main pulmonary artery is shorter and somewhat smaller than the right, passes horizontally in front of the descending aorta and left bronchus to the root of the left lung. (wikipedia.org)
  • Above, the left main pulmonary artery is connected to the concavity of the proximal descending aorta by the ligamentum arteriosum. (wikipedia.org)
  • Normally, the left and right coronary arteries arise from the aorta and supply blood with oxygen to the heart. (childrenshospital.org)
  • ALCAPA occurs when the left coronary artery, which takes blood to the heart, is connected to the pulmonary artery instead of to the aorta. (patientslikeme.com)
  • Options for repair include detaching the anomalous left coronary artery from the pulmonary artery and moving it over to the aorta directly (translocation) or creating a natural tunnel from its abnormal location to the aorta (Takeuchi repair). (childrenshospital.org)
  • The right pulmonary artery wedges in the aortic arch , behind the ascending aorta and in front of the descending aorta. (verywellhealth.com)
  • The left pulmonary artery extends near the left side of the aorta . (verywellhealth.com)
  • If your child's been diagnosed with anomalous origin of the right or left pulmonary artery off the aorta, we're here to ease your concerns, answer your questions, and give your child the best possible chance for a healthy future. (nemours.org)
  • Sometimes, instead of connecting the main pulmonary artery to a lung, one of those branches makes a connection between the aorta and the lung. (nemours.org)
  • Anomalous origin of the right or left pulmonary artery off the aorta is usually diagnosed at birth or soon after. (nemours.org)
  • To repair an anomalous origin of the right or left pulmonary artery off the aorta, we perform open-heart surgery using a patch soon after diagnosis. (nemours.org)
  • If your child has anomalous origin of the right or left pulmonary artery off the aorta, know that at the Nemours Cardiac Center we're here to give your child the very best, most comprehensive and compassionate care. (nemours.org)
  • The dissection is usually limited to the pulmonary trunk but sometimes extends to the subsegmentary branches or aorta. (em-consulte.com)
  • The ascending aorta should be cannulated very close to the innominate artery to provide a long length of ascending aorta for the cardioplegia administration site and for the orifice that is to be created on the side of the aorta for the aortic implantation. (ctsnet.org)
  • Chi-square values indicated tumor location in the pulmonary valve and aorta were significant factors in mean survival time (P=0.004, P=0.23 respectively), as well as metastasis and tumor recurrence (P=0.003, P=0.001 respectively). (omicsonline.org)
  • Fluorescence emission intensity from a culture of bovine pulmonary artery endothelial cells stained with BODIPY FL phallacidin, which binds to the intracellular filamentous actin network. (microscopyu.com)
  • A complete solution to propagate pulmonary artery endothelial cells in low serum conditions with or without the addition of human recombinant VEGF. (atcc.org)
  • Fluorescence emission intensity from a culture of bovine pulmonary artery endothelial cells stained with MitoTracker Red CMXRos, which targets the intracellular mitochondrial network. (microscopyu.com)
  • Primary human pulmonary artery endothelial cells cryopreserved at the end of the tertiary culture. (thermofisher.com)
  • Distribution of Mitochondria in BPAE Cell Cultures - A culture of bovine pulmonary artery endothelial cells was stained with MitoTracker Red CMXRos, vividly labeling the intracellular mitochondrial network. (fsu.edu)
  • View a larger image of the bovine pulmonary artery endothelial (BPAE) cells. (fsu.edu)
  • The pulmonary arteries take blood from the heart to the lungs. (medlineplus.gov)
  • The pulmonary artery is the major blood vessel that takes oxygen-poor blood from the heart to the lungs to pick up oxygen. (medlineplus.gov)
  • Through the contractions or pumping of the right ventricle, the heart feeds the blood into the main pulmonary artery or trunk, and then this blood travels through the left or right pulmonary arteries to reach the lungs. (wisegeek.com)
  • The pulmonary artery carries oxygen-poor blood from the right ventricle of the heart to the lungs . (kidshealth.org)
  • Both arteries are supposed to pass in front of the trachea as they carry blood to the lungs. (kidshealth.org)
  • The pulmonary artery carries deoxygenated blood from the heart to the lungs . (wn.com)
  • The pulmonary artery is the large vessel that takes deoxygenated blood cells from the heart to the lungs. (wellcomecollection.org)
  • pulmonary circulation the circulation of blood to and from the lungs. (thefreedictionary.com)
  • Unoxygenated blood from the right ventricle flows through the right and left pulmonary arteries to the right and left lungs. (thefreedictionary.com)
  • A pulmonary artery is an artery in the pulmonary circulation that carries deoxygenated blood from the right side of the heart to the lungs. (wikipedia.org)
  • The pulmonary arteries are blood vessels that carry blood from the right side of the heart through to the capillaries of the lungs. (wikipedia.org)
  • During early development, the ductus arteriosis connects the pulmonary trunk and the aortic arch, allowing blood to bypass the lungs. (wikipedia.org)
  • In contrast to the pulmonary arteries, the bronchial arteries supply nutrition to the lungs themselves. (wikipedia.org)
  • Pulmonary arteries, which extend from the heart to the lungs, are the only arteries in the mammalian body that carry dark, unoxygenated blood. (fsu.edu)
  • histologically the lungs showed multiple obstructive lesions at medium size pulmonary artery level. (bmj.com)
  • It divides into the left and right pulmonary arteries, which carry blood with relatively low oxygen content and high carbon dioxide content into the lungs . (verywellhealth.com)
  • The left and right pulmonary arteries send blood to the left and right lungs, respectively. (verywellhealth.com)
  • The most common anatomic variations of the pulmonary arteries are variations in the number of arterial branches in the lungs. (verywellhealth.com)
  • This is a condition in which the pulmonary valve does not open properly, resulting in diminished blood flow from the heart to the lungs. (verywellhealth.com)
  • The main pulmonary artery then branches into a right and left pulmonary artery that carry the blood to the right and left lungs. (nemours.org)
  • 5. The lead of claim 3 , further comprising a second pacing electrode disposed on the intermediate portion of the lead and located on the lead so as to be located proximate a ventricular outflow tract when the distal portion of the lead is within the pulmonary artery. (google.com)
  • 10. The lead of claim 3 , wherein the pre-formed, biased shape on the distal end of the lead includes at least two surfaces positioned to contact opposing walls of the pulmonary artery. (google.com)
  • The lead can include a distal end adapted for being passively fixated within a pulmonary artery. (google.com)
  • In one aspect, a lead having a lead body extending from a proximal end to a distal end and having an intermediate section, the distal end being adapted for being passively fixated within a pulmonary artery. (google.com)
  • The lead includes a shocking electrode coupled proximate the distal end of the lead body, wherein the lead is adapted to be placed within a heart in a J-shaped configuration such that the electrode is positioned within the pulmonary artery and the distal end is fixated within the pulmonary artery. (google.com)
  • Favorable response to short-term drug testing (ie, inhaled nitric oxide, prostacyclin) is defined by a 20% decrease in the mean pulmonary artery pressure and/or no change or an increase in cardiac output. (medscape.com)
  • However, there has not been systematic characterization of the basic physiological pulmonary vascular reactivity in normal and transgenic mice. (nih.gov)
  • This represents an intellectual "gap", since it is important to characterize basic murine pulmonary vascular reactivity in response to various contractile and relaxant factors to which the pulmonary vasculature is exposed under physiological conditions. (nih.gov)
  • In fact, the small pulmonary veins and capillaries account for approximately 40% of the total pulmonary vascular resistance. (medscape.com)
  • The rationale for this approach is that some degree of pulmonary vascular remodeling may occur with long-term vasodilator therapy, especially in children. (medscape.com)
  • In this issue of JCI Insight , a team led by Laura Fredenburgh of Brigham and Women's Hospital shows that alterations in pulmonary arterial stiffness occur early during disease and promote vascular remodeling by altering signaling mediated by prostaglandins, a class of hormones that regulate inflammation, smooth muscle contraction, and vasoconstrictoin. (brightsurf.com)
  • The increased pulmonary vascular resistance in PAH has been attributed to 2 major factors, vasoconstriction and remodeling of the vascular wall. (ahajournals.org)
  • However, recent studies in animal models of severe occlusive PAH showed that a sustained Rho kinase-mediated vasoconstriction is the primary determinant of increased pulmonary vascular resistance. (ahajournals.org)
  • 5 Important to this concept is evidence that pulmonary vascular tone is modulated by factors released from the endothelium. (ahajournals.org)
  • (4) demonstrated that PADN reduced pulmonary artery pressure and pulmonary vascular resistance, diminished right ventricular hypertrophy, and partially reversed the pulmonary vascular remodeling. (onlinejacc.org)
  • The systolic pressure of a right ventricular tracing will be the same as the pulmonary artery pressure, but the diastolic right ventricle pressure will be lower than the pulmonary artery diastolic. (lhsc.on.ca)
  • A transthoracic Doppler echocardiogram, which had been performed previously, showed moderate right heart enlargement, and pulmonary artery systolic pressure (PASP) was estimated to be 76 mmHg. (scielo.br)
  • The dissection commences immediately proximal to the lingular segmental artery branch (arrowhead, fig 1C ). (bmj.com)
  • 5 mm volume-rendered sagittal oblique image demonstrates moderate narrowing of the proximal left lower lobe (LLL) pulmonary artery (PA). (massgeneral.org)
  • Chest computed tomography and coronary angiography revealed a giant aneurysm and coronary-pulmonary artery fistula originating from both the proximal left anterior descending and the right coronary artery. (umin.ac.jp)
  • This report describes a case of complex coronary-pulmonary artery fistula with two feeding vessels of separate origins: one from the proximal part of the left anterior descending artery and another arising from the right aortic cusp. (bmj.com)
  • Enhanced CT scan showed a localized intimal flap in the proximal right pulmonary artery. (em-consulte.com)
  • Intimal flap in the proximal right pulmonary artery. (em-consulte.com)
  • This helps to maintain a closed chamber in the proximal main pulmonary artery and increase the pressure in the left coronary artery system, assisting in perfusing the portion of the myocardium supplied by the anomalous left coronary artery. (ctsnet.org)
  • See also pulmonary wedge pressure and ventricular pressure . (wikipedia.org)
  • Obtain a tracing of the right atrial, right ventricle, pulmonary artery and pulmonary wedge pressure tracing during insertion (you can retrieve these from the full disclosure, hemodynamic option at the central station). (lhsc.on.ca)
  • pulmonary artery wedge pressure is a topic covered in the Taber's Medical Dictionary . (tabers.com)
  • Taber's Online , www.tabers.com/tabersonline/view/Tabers-Dictionary/731324/all/pulmonary_artery_wedge_pressure. (tabers.com)
  • Light micrograph of a section through part of the wall of a normal human pulmonary artery, an elastic artery. (sciencephoto.com)
  • The pulmonary artery is the narrowing of a major blood vessel of the heart. (patientslikeme.com)
  • The previously occult pulmonary artery was found in 10 patients, in five of whom a vestige of an intrapericardial artery was present and in five the artery was patent only at the hilus, a gap existing between the main pulmonary artery and the hilar vessel, and no artery was found in one. (bmj.com)
  • In those without an intrapericardial vessel the occult artery was on the side opposite the aortic arch, and there was evidence of a ductus coming from the innominate artery on the side of the interruption. (bmj.com)
  • It seems advisable to search for the occult artery as early in life as is feasible in the hope that providing a blood supply will ensure development of the vessel and normal lung growth. (bmj.com)
  • Axial and oblique coronal MPR reformations of the contrast-enhanced CT revealed the RUL mass to be tubular in shape arising adjacent to a right hilar-pulmonary vessel (Figure 6 and 7). (appliedradiology.com)
  • 3,4 Rarely, injuries to the pulmonary arteries lead to vessel rupture with focal bleeding into the surrounding lung parenchyma that may be limited by thrombus formation, extravascular tissue compression, or both, leading to the formation of a pseudoaneurysm. (appliedradiology.com)
  • The coronary arteries were normal without coronary artery disease, vessel narrowing or wall thickening. (massgeneral.org)
  • Early in IPAH, most pulmonary vessel constriction is believed to be reversible. (medscape.com)
  • When found in the body lining the pulmonary arteries, these cells are usually arranged so that their long axis is oriented parallel to the direction of blood flow in the vessel. (fsu.edu)
  • The main pulmonary artery, also called the pulmonary trunk, is a vessel that emerges from the heart. (verywellhealth.com)
  • DORV falls within the spectrum of conotruncal abnormalities that range from tetralogy of Fallot to complete transposition of the great arteries 1 . (massgeneral.org)
  • Unilateral pulmonary artery agenesis is a rare congenital anomaly often associated with other cardiovascular abnormalities. (biomedsearch.com)
  • Patients with complex pulmonary artery abnormalities present a significant challenge for congenital heart programs. (stanford.edu)
  • Join us to learn the current medical and surgical approach to patients with syndromic pulmonary artery abnormalities, major aortopulmonary collaterals (MAPCAs), and right ventricular outflow tract obstruction. (stanford.edu)
  • This CME workshop seeks to fulfill the need amongst pediatric cardiologists and cardiac surgeons to improve the fund of knowledge in caring for patients with complex pulmonary artery abnormalities. (stanford.edu)
  • The occult pulmonary artery, where identified at operation, was usually joined initially to the systemic circulation. (bmj.com)
  • On occasion, the anomalous pulmonary artery may supply only the left upper lobe with normal pulmonary arterial supply to the left lower lobe. (medscape.com)
  • 5 The reported occurrence of pulmonary artery rupture is 0.02% to 0.4%, 6,7 and these events occur more commonly in segmental pulmonary arteries to the right lower lobe and right middle lobe, carrying up to 50% mortality secondary to aspiration and asphyxia due to uncontrolled massive hemoptysis. (appliedradiology.com)
  • CT pulmonary angiography excluded signs of acute or chronic thromboembolism but demonstrated a 4 cm long dissection flap in the lower lobe segmental branch of the left pulmonary artery ( fig 1 ). (bmj.com)
  • A-C) Volume rendered oblique coronal and axial images showing the relationship of the dissection flap (short arrows) to the left lower lobe pulmonary artery. (bmj.com)
  • Diagnostic pulmonary angiography with successful angioplasty and stenting of the interlobar right pulmonary artery, right upper lobe pulmonary artery and left lower lobe pulmonary artery was subsequently performed (Figure B and D). (massgeneral.org)
  • Computed tomography and coronary angiography showed that the aneurysm and coronary-pulmonary artery fistula had completely disappeared. (umin.ac.jp)
  • Pulmonary artery aneurysms should be included in the differential diagnosis of lung masses. (hindawi.com)
  • Thus, early recognition and diagnosis of pulmonary artery sling, and of stridor in a young infant, are crucial. (medscape.com)
  • Preoperative diagnosis of a pulmonary artery sarcoma. (bmj.com)
  • They are used to evaluate patients in the diagnosis of pulmonary disease, assessment of disease development, or evaluation of the risk of pulmonary complications from surgery. (thefreedictionary.com)
  • Intimal sarcoma of the pulmonary artery is a rare and potentially lethal tumor, the diagnosis of which is difficult and therefore frequently delayed. (scielo.br)
  • Cardiac CT demonstrated normal caliber of the entire main pulmonary arterial tree (Figure 2). (massgeneral.org)
  • DORV is an uncommon congenital cardiac defect characterized by the morphologic right ventricle being the primary origin of both great arteries. (massgeneral.org)
  • Subjects without associated cardiac anomalies (isolated unilateral pulmonary artery agenesis) may be asymptomatic or have recurrent respiratory infections. (biomedsearch.com)
  • The aims of this study were to determine the agreement between pulmonary artery thermodilution (PA-TD), transpulmonary thermodilution (TP-TD) and the pulse contour method, and to test the ability of the pulse contour method to track changes in cardiac output. (wiley.com)
  • Coronary-pulmonary artery fistula is an uncommon cardiac anomaly, usually congenital. (bmj.com)
  • Dilatation of the pulmonary artery may lead to the compression of adjacent structures. (ad-astra.ro)
  • The anomalous left pulmonary artery courses over the right mainstem bronchus and then from right to left, posterior to the trachea or carina and anterior to the esophagus, to reach the hilum of the left lung. (medscape.com)
  • In addition, partial anomalous supply of the right upper lobe of the lung from the anomalous left pulmonary artery has been described. (medscape.com)
  • Pulmonary artery (pul-muh-NAIR-ee AR-tuh-REE) sling is a rare condition children can be born with, in which the left pulmonary artery comes out of the right pulmonary artery and passes between the trachea (TRAY-kee-uh) and the esophagus (ih-SAH-fuh-gus) to reach the left lung. (kidshealth.org)
  • To reach the left lung, the left pulmonary artery passes in between the trachea and the esophagus, which carries food and fluids from the mouth to the stomach. (kidshealth.org)
  • It then branches into two pulmonary arteries (left and right), which deliver deoxygenated blood to the corresponding lung . (wn.com)
  • it starts as the pulmonary trunk, which divides between the fifth and sixth thoracic vertebrae to form the right pulmonary artery that enters the right lung and the left pulmonary artery that enters the left lung. (thefreedictionary.com)
  • pulmonary function tests tests used to evaluate lung mechanics, gas exchange, pulmonary blood flow, and blood gases and pH. (thefreedictionary.com)
  • PCWP is the measurement by which changes in lung water (pulmonary capillary hydrostatic pressure [PCHP]) can be assessed. (medscape.com)
  • It then divides into two lobar arteries, one for each lobe of the left lung. (wikipedia.org)
  • Upon reaching the hilum of the right lung the right main pulmonary artery divides into two branches: truncus anterior - supplies blood to the right upper lobe interlobar artery - inferior and larger branch, supplies blood to the middle and inferior lobes of the lung The right and left main pulmonary arteries give off branches that roughly correspond to the lung lobes and can in such cases be termed lobar arteries. (wikipedia.org)
  • Because the heart is on the left side of the chest, the left pulmonary artery is closer to the lung than the right pulmonary artery. (verywellhealth.com)
  • After the left pulmonary artery enters the left lung, it divides into smaller branches. (verywellhealth.com)
  • The right pulmonary artery courses across the upper chest to enter the right lung. (verywellhealth.com)
  • The clinical case is of a 53-year-old woman with recurrent pulmonary emboli, claudication of legs, dyspnea and hemoptysis whom was later discovered to have a large (12.0x6.5x5.0 cm) intravascular lung pulmonary artery intimal sarcoma with satellite pulmonary metastases. (omicsonline.org)
  • In a recent such case the worm was identified as a sexually mature, infertile female Brugia , probably B. malayi , in a normal artery situated some distance from the lesion, and it apparently was alive when removed in resected lung tissue. (ajtmh.org)
  • Pulmonary artery sling is a rare defect created by anomalous origin of the left pulmonary artery from the posterior aspect of the right pulmonary artery . (medscape.com)
  • Congenital heart defects are found in 50% of pulmonary artery sling cases, most commonly atrial septal defect , patent ductus arteriosus , ventricular septal defect , and left superior vena cava. (medscape.com)
  • That's why Nemours pediatric heart experts specialize in early detection and repair of congenital heart defects like pulmonary artery sling. (nemours.org)
  • A surgical method of decreasing pulmonary blood flow and thereby volume overload of the left ventricle , alleviating congestive heart failure (CHF) in certain congenital heart defects. (lymphedemapeople.com)
  • 3. Large pulmonary artery aneurysm. (aapc.com)
  • I have 33475 and 33533, but can't find a code for the pulmonary artery aneurysm repair. (aapc.com)
  • how do I code a coronary artery aneurysm repair. (aapc.com)
  • A saccular aneurysm arises from the descending branch of each pulmonary. (radiopaedia.org)
  • These arise from the pulmonary trunk (sometimes called the main artery) and are called right and left pulmonary arteries. (wisegeek.com)
  • There is only one time in life when most people don't have much need for the pulmonary artery or trunk. (wisegeek.com)
  • In the human heart , the pulmonary trunk ( pulmonary artery or main pulmonary artery ) begins at the base of the right ventricle . (wn.com)
  • 2 These demonstrated dissection in the main pulmonary trunk, which is the affected site in 80% (usually without involvement of its branches). (bmj.com)
  • The largest pulmonary artery is the main pulmonary artery or pulmonary trunk from the heart, and the smallest ones are the arterioles, which lead to the capillaries that surround the pulmonary alveoli. (wikipedia.org)
  • In order of blood flow, the pulmonary arteries start as the pulmonary trunk or main pulmonary artery. (wikipedia.org)
  • The opening if of the pulmonary artery (or pulmonary trunk) is circular, and situated at the summit of the conus arteriosus, close to the ventricular septum. (wikipedia.org)
  • A transesophageal echocardiogram demonstrated extensive thrombosis in the pulmonary artery trunk and PASP of 57 mmHg. (scielo.br)
  • Angiotomography of the chest revealed a large filling defect in the mediastinal and pericardial portion of the pulmonary trunk and arteries, there being enhancement of that defect after intravenous administration of contrast material ( Figure 1a ). (scielo.br)
  • The pulmonary trunk and the left and right pulmonary arteries are relatively large arteries. (verywellhealth.com)
  • The pulmonary trunk and the right and left pulmonary arteries are shaped somewhat like a capital letter "T", with the trunk forming the lower portion and the left and right branches each forming one of the two sides at the top. (verywellhealth.com)
  • There is a valve between the right ventricle of the heart and the pulmonary trunk. (verywellhealth.com)
  • This valve, which is composed of two cusps of connective tissue, is structured to open when the heart pumps so the blood can flow from the right ventricle to the pulmonary trunk. (verywellhealth.com)
  • The pulmonary trunk, which is relatively short and wide, is located at the exit of the right ventricle. (verywellhealth.com)
  • This is a congenital defect in which the left pulmonary artery branches off the right pulmonary artery, rather than directly from the pulmonary trunk. (verywellhealth.com)
  • The pulmonary artery trunk was dilated as a consequence of chronic overloading. (em-consulte.com)
  • Elevated Pulmonary Artery Pressure by Doppler Echocardiography Predicts Hospitalization for Heart Failure and Mortality in Ambulatory Stable Coronary Artery Disease. (ovid.com)
  • The course of the anomalous left pulmonary artery to the right of the trachea produces deviation of the lower trachea to the left with resulting compression of the right mainstem bronchus and lower trachea. (medscape.com)
  • Anomalous left coronary artery from the pulmonary artery (ALCAPA) is a heart defect. (medlineplus.gov)
  • Expert consensus guidelines: anomalous aortic origin of a coronary artery. (medlineplus.gov)
  • Sugimoto S, Kikuchi S, Oosawa H, Hachiro Y, Takagi N, Abe T. A reoperation for anomalous origin of right pulmonary artery: report of a case. (springer.com)
  • Anomalous left coronary artery from the pulmonary artery (ALCAPA) is a congenital (present at birth) heart defect in which the left coronary artery arises abnormally from the pulmonary artery. (childrenshospital.org)
  • Anomalous left coronary artery from the pulmonary artery (ALCAPA) is a rare defect of the heart that is present at birth. (patientslikeme.com)
  • Got a question about living with Anomalous left coronary artery from the pulmonary artery? (patientslikeme.com)
  • Who has Anomalous left coronary artery from the pulmonary artery on PatientsLikeMe? (patientslikeme.com)
  • Surgery is needed to treat anomalous left coronary artery from the pulmonary artery (ALCAPA). (childrenshospital.org)
  • Anomalous origin of the left coronary artery from the pulmonary artery (ALCAPA) is a rare congenital anomaly that is one of the most common causes of myocardial ischemia and infarction in children. (ctsnet.org)
  • The schematic view shows the typical location of the anomalous left coronary artery from the posterior sinus of the main pulmonary artery. (ctsnet.org)
  • The angle of the left pulmonary artery is more acute than in normal patients, in part due to congenital conotruncal rotation. (massgeneral.org)
  • American Roentgen Ray Society) According to ARRS' American Journal of Roentgenology, the imaging findings of in situ pulmonary artery thrombosis (PAT) associated with radiation therapy (RT) are different from those of acute pulmonary emboli and do not appear to embolize. (medworm.com)
  • This value may be even higher in critically ill patients in whom pulmonary venoconstriction is common secondary to conditions such as hypoxemia and acute respiratory distress syndrome (ARDS). (medscape.com)
  • There was no difference in age, gender, history of acute chest syndrome, hydroxyurea therapy, chronic blood transfusion, stroke, hemoglobin, and bilirubin between patients with and without elevated pulmonary artery pressures. (aappublications.org)
  • Patient 2 died from acute right heart failure after a period of 11 months from the time of transcatheter closure, triggered by pulmonary infection. (dovepress.com)
  • The lobar arteries branch into segmental arteries (roughly 1 for each lobe segment), which in turn branch into subsegmental pulmonary arteries. (wikipedia.org)
  • SPC (1 μmol/L) caused translocation of PKCδ to the perinuclear region and cytoskeleton of cultured intrapulmonary artery smooth muscle cells. (ahajournals.org)
  • Pulmonary artery smooth muscle cells grown on matrices with enhanced stiffness exhibited increased proliferation, contraction, and production of matrix proteins. (brightsurf.com)
  • Distinct activity of BK channel β1-subunit in cerebral and pulmonary artery smooth muscle cells. (sigmaaldrich.com)
  • This study was designed to test a hypothesis that the functional activity of big-conductance, Ca(2+)-activated K(+) (BK) channels is different in cerebral and pulmonary artery smooth muscle cells (CASMCs and PASMCs). (sigmaaldrich.com)
  • A retrospective study showed a hospital-based prevalence of 0.14% for left pulmonary artery sling among Chinese patients with congenital heart disease. (medscape.com)
  • Of 12 patients with angiographically absent pulmonary artery, 11 were investigated surgically. (bmj.com)
  • All patients with an intrapericardial artery had right ventricular outflow tract obstruction and a ductus descending vertically from underneath the aortic arch. (bmj.com)
  • 11 It is alleged that atherosclerotic changes of the pulmonary vessels in these patients makes them less compliant and more fragile than normal vessels. (appliedradiology.com)
  • Elevated echo-Doppler estimates of pulmonary artery pressure predict heart failure and death in CAD patients. (ovid.com)
  • Patients who have Alagille Syndrome (AGS) also frequently have blockages (or 'stenoses') of their pulmonary arteries. (clinicaltrials.gov)
  • 2 In patients with PAH that were refractory to other vasodilators, the administration of the Rho-kinase inhibitor fasudil decreased pulmonary arterial pressure. (ahajournals.org)
  • Patients who performed deep breathing exercises after CABG had significantly smaller atelectasis and better pulmonary function on the fourth postoperative day compared to a control group who performed no exercises. (diva-portal.org)
  • Color Doppler echocardiography demonstrates the main pulmonary artery bifurcation with turbulent flow. (massgeneral.org)
  • Structurally normal heart except for a prominent main pulmonary artery at the level of the origin of the ductus arteriosus. (medhelp.org)
  • Ultimately, continuity between the hilar and main pulmonary artery may be established surgically. (bmj.com)
  • The main pulmonary arteries emerge from the right side of the heart, and these split into smaller arteries that progressively divide and become smaller until they become arterioles and eventually capillaries. (wikipedia.org)
  • The main pulmonary artery splits into the right and the left main pulmonary artery. (wikipedia.org)
  • The right main pulmonary artery follows a longer and more horizontal course as it crosses the mediastinum. (wikipedia.org)
  • The pulmonary artery pressure (PA pressure) is a measure of the blood pressure found in the main pulmonary artery. (wikipedia.org)
  • However, chronic thrombosis of the main pulmonary artery or of the right or left main branches is, in contrast, a rare finding and reported cases are limited in number. (annals.org)
  • The snares on the right and left pulmonary arteries continue to create a closed chamber in the main pulmonary artery, completed by the closed pulmonary valve. (ctsnet.org)
  • After the first dose of cardioplegia, the main pulmonary artery is transected after fully mobilizing the right and left pulmonary arteries and ligating and dividing the ligamentum arteriosum or patent ductus arteriosus. (ctsnet.org)
  • The photograph shows the partially transected main pulmonary artery. (ctsnet.org)
  • Thoracic manifestations of Behcet disease include multiple bilateral pulmonary artery aneurysms that are of fusiform or saccular type and usually involves the main pulmonary artery or its descending branch. (radiopaedia.org)
  • As with all arteries, the walls of the pulmonary arteries have several layers of muscle that allow them to dilate (widen) and constrict (become narrow). (verywellhealth.com)
  • Infants with cyanotic congenital heart disease palliated with placement of a systemic-to-pulmonary-artery shunt are at risk for shunt thrombosis and death. (nih.gov)
  • As one descends the pulmonary arterial tree, thrombosis becomes more common, depending upon the diligence with which prosection is done. (annals.org)
  • Aberrant left pulmonary artery or pulmonary artery sling. (medscape.com)
  • As the left pulmonary artery passes posteriorly and caudally to the right main-stem bronchus and to the left behind the trachea, tracheal and bronchial compression occurs. (medscape.com)
  • The patient had left internal mammary artery to his LAD. (aapc.com)
  • Normally, the pulmonary artery splits in two just after leaving the heart to form the right and left pulmonary arteries. (kidshealth.org)
  • When someone has a pulmonary artery sling (PAS), the left pulmonary artery comes out of the right pulmonary artery a short distance from the heart. (kidshealth.org)
  • Treatment for PAS involves surgery to detach the left pulmonary artery from the right pulmonary artery and reattach it to the pulmonary artery stem in front of the trachea. (kidshealth.org)
  • We report a case of left pulmonary artery agenesis in a 35-year-old man complicated by hemoptysis and treated by pneumonectomy. (biomedsearch.com)
  • These veins join to form the pulmonary veins, which return the oxygenated blood to the left atrium. (thefreedictionary.com)
  • It is placed above and to the left of the atrioventricular opening, and is guarded by the pulmonary semilunar valves. (wikipedia.org)
  • In children with ALCAPA, the left coronary artery arises from the pulmonary artery and carries blood without oxygen to the left side of the heart. (childrenshospital.org)
  • Arterial pressure was 140/80 mmHg, there was turgescence of the jugular veins (4+/4), and pulmonary auscultation revealed third heart sound along the lower left sternal border and systolic ejection murmur in pulmonary focus. (scielo.br)
  • Of those, the extrinsic compression of the left main coronary artery is the most worrisome. (ad-astra.ro)
  • The presence of this isolated lesion in a young woman without risk factors for atherosclerosis suggests extrinsic compression of the left main coronary artery by the dilated pulmonary artery as the likely mechanism. (ad-astra.ro)
  • And sometimes, one or more divisions can branch off before the right or left pulmonary artery enters the heart. (verywellhealth.com)
  • ICD-10-PCS code 02CR0ZZ for Extirpation of Matter from Left Pulmonary Artery, Open Approach is a medical classification as listed by CMS under Heart and Great Vessels range. (aapc.com)
  • The establishment of a two coronary artery system has been shown to result in complete recovery from myocardial dysfunction despite the severe nature of the preoperative left ventricular failure. (ctsnet.org)
  • Rumel tourniquets have been passed around the right and left pulmonary arteries and have been employed once bypass has started. (ctsnet.org)
  • A vent is placed in the right superior pulmonary vein and passes through the left atrium into the left ventricle to decompress the left ventricle during the procedure. (ctsnet.org)
  • In the photograph, the cardioplegia is being administered, the right and left pulmonary arteries are snared, and ice slush has been delivered to cool and protect the myocardium. (ctsnet.org)
  • Clinical observations regarding the safety and efficacy of stent implantation in branch pulmonary arteries and their influence on clinical management have been encouraging(1). (massgeneral.org)
  • The clinical entity of unilateral pulmonary artery absence or hypoplasia can be readily diagnosed on the basis of routine clinical evaluation. (ahajournals.org)
  • Hemoptysis resulting from unilateral pulmonary artery agenesis. (biomedsearch.com)
  • Physicians should be aware of unilateral pulmonary artery agenesis presenting later in life as a source of chronic respiratory symptomatology or hemoptysis. (biomedsearch.com)
  • The clinical signs and symptoms are nonspecific, often mimicking chronic pulmonary thromboembolism (CPTE). (scielo.br)
  • (4) The true incidence of intimal sarcoma of the pulmonary artery is unknown, but it is likely that this disease is underdiagnosed due to its similarity to chronic pulmonary thromboembolism (CPTE). (scielo.br)
  • A pulmonary artery sarcoma was diagnosed preoperatively by magnetic resonance imaging enhanced with gadolinium and confirmed by percutaneous computed tomographic guided needle biopsy. (bmj.com)
  • Intimal sarcoma of the pulmonary artery is extremely rare. (scielo.br)
  • Statement of the Problem: Pulmonary artery intimal sarcoma (PAIS) is a rare, aggressive tumor often diagnosed at autopsy. (omicsonline.org)
  • The most common clinical manifestations of pulmonary artery rupture are cough, hemoptysis, hypoxemia, and exsanguination. (appliedradiology.com)
  • The pulmonary artery is relevant in a number of clinical states. (wikipedia.org)
  • Most studies have found, a posteriori, 'acceptable' agreement between TP-TD, the pulse contour method and the de facto clinical standard - pulmonary artery thermodilution (PA-TD) (2-9) . (wiley.com)