A species of gram-negative, aerobic, rod-shaped bacteria commonly isolated from clinical specimens (wound, burn, and urinary tract infections). It is also found widely distributed in soil and water. P. aeruginosa is a major agent of nosocomial infection.
Infections with bacteria of the genus PSEUDOMONAS.
A genus of gram-negative, aerobic, rod-shaped bacteria widely distributed in nature. Some species are pathogenic for humans, animals, and plants.
A species of gram-negative, aerobic bacteria isolated from soil and water as well as clinical specimens. Occasionally it is an opportunistic pathogen.
Proteins found in any species of bacterium.
A species of nonpathogenic fluorescent bacteria found in feces, sewage, soil, and water, and which liquefy gelatin.
An autosomal recessive genetic disease of the EXOCRINE GLANDS. It is caused by mutations in the gene encoding the CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR expressed in several organs including the LUNG, the PANCREAS, the BILIARY SYSTEM, and the SWEAT GLANDS. Cystic fibrosis is characterized by epithelial secretory dysfunction associated with ductal obstruction resulting in AIRWAY OBSTRUCTION; chronic RESPIRATORY INFECTIONS; PANCREATIC INSUFFICIENCY; maldigestion; salt depletion; and HEAT PROSTRATION.
Substances that reduce the growth or reproduction of BACTERIA.
Viruses whose host is Pseudomonas. A frequently encountered Pseudomonas phage is BACTERIOPHAGE PHI 6.
Antibiotic pigment produced by Pseudomonas aeruginosa.
Salts of alginic acid that are extracted from marine kelp and used to make dental impressions and as absorbent material for surgical dressings.
Enzymes that transfer the ADP-RIBOSE group of NAD or NADP to proteins or other small molecules. Transfer of ADP-ribose to water (i.e., hydrolysis) is catalyzed by the NADASES. The mono(ADP-ribose)transferases transfer a single ADP-ribose. POLY(ADP-RIBOSE) POLYMERASES transfer multiple units of ADP-ribose to protein targets, building POLY ADENOSINE DIPHOSPHATE RIBOSE in linear or branched chains.
Any tests that demonstrate the relative efficacy of different chemotherapeutic agents against specific microorganisms (i.e., bacteria, fungi, viruses).
Encrustations, formed from microbes (bacteria, algae, fungi, plankton, or protozoa) embedding in extracellular polymers, that adhere to surfaces such as teeth (DENTAL DEPOSITS); PROSTHESES AND IMPLANTS; and catheters. Biofilms are prevented from forming by treating surfaces with DENTIFRICES; DISINFECTANTS; ANTI-INFECTIVE AGENTS; and antifouling agents.
Any of the processes by which cytoplasmic or intercellular factors influence the differential control of gene action in bacteria.
An aminoglycoside, broad-spectrum antibiotic produced by Streptomyces tenebrarius. It is effective against gram-negative bacteria, especially the PSEUDOMONAS species. It is a 10% component of the antibiotic complex, NEBRAMYCIN, produced by the same species.
The functional hereditary units of BACTERIA.
A phenomenon where microorganisms communicate and coordinate their behavior by the accumulation of signaling molecules. A reaction occurs when a substance accumulates to a sufficient concentration. This is most commonly seen in bacteria.
Bacteriocins elaborated by mutant strains of Pseudomonas aeruginosa. They are protein or protein-lipopolysaccharide complexes lethal to other strains of the same or related species.
A sugar acid formed by the oxidation of the C-6 carbon of GLUCOSE. In addition to being a key intermediate metabolite of the uronic acid pathway, glucuronic acid also plays a role in the detoxification of certain drugs and toxins by conjugating with them to form GLUCURONIDES.
Broad-spectrum semisynthetic penicillin derivative used parenterally. It is susceptible to gastric juice and penicillinase and may damage platelet function.
Those components of an organism that determine its capacity to cause disease but are not required for its viability per se. Two classes have been characterized: TOXINS, BIOLOGICAL and surface adhesion molecules that effect the ability of the microorganism to invade and colonize a host. (From Davis et al., Microbiology, 4th ed. p486)
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Toxins produced, especially by bacterial or fungal cells, and released into the culture medium or environment.
Semisynthetic, broad-spectrum antibacterial derived from CEPHALORIDINE and used especially for Pseudomonas and other gram-negative infections in debilitated patients.
Semisynthetic thienamycin that has a wide spectrum of antibacterial activity against gram-negative and gram-positive aerobic and anaerobic bacteria, including many multiresistant strains. It is stable to beta-lactamases. Clinical studies have demonstrated high efficacy in the treatment of infections of various body systems. Its effectiveness is enhanced when it is administered in combination with CILASTATIN, a renal dipeptidase inhibitor.
Deoxyribonucleic acid that makes up the genetic material of bacteria.
Bacteria which lose crystal violet stain but are stained pink when treated by Gram's method.
A species of gram-negative, fluorescent, phytopathogenic bacteria in the genus PSEUDOMONAS. It is differentiated into approximately 50 pathovars with different plant pathogenicities and host specificities.
One of the FURANS with a carbonyl thereby forming a cyclic lactone. It is an endogenous compound made from gamma-aminobutyrate and is the precursor of gamma-hydroxybutyrate. It is also used as a pharmacological agent and solvent.
The ability of microorganisms, especially bacteria, to resist or to become tolerant to chemotherapeutic agents, antimicrobial agents, or antibiotics. This resistance may be acquired through gene mutation or foreign DNA in transmissible plasmids (R FACTORS).
Enzymes found in many bacteria which catalyze the hydrolysis of the amide bond in the beta-lactam ring. Well known antibiotics destroyed by these enzymes are penicillins and cephalosporins.
A complex of closely related aminoglycosides obtained from MICROMONOSPORA purpurea and related species. They are broad-spectrum antibiotics, but may cause ear and kidney damage. They act to inhibit PROTEIN BIOSYNTHESIS.
Infections in the inner or external eye caused by microorganisms belonging to several families of bacteria. Some of the more common genera found are Haemophilus, Neisseria, Staphylococcus, Streptococcus, and Chlamydia.
Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.
Term used to designate tetrahydroxy aldehydic acids obtained by oxidation of hexose sugars, i.e. glucuronic acid, galacturonic acid, etc. Historically, the name hexuronic acid was originally given to ascorbic acid.
One of the three domains of life (the others being Eukarya and ARCHAEA), also called Eubacteria. They are unicellular prokaryotic microorganisms which generally possess rigid cell walls, multiply by cell division, and exhibit three principal forms: round or coccal, rodlike or bacillary, and spiral or spirochetal. Bacteria can be classified by their response to OXYGEN: aerobic, anaerobic, or facultatively anaerobic; by the mode by which they obtain their energy: chemotrophy (via chemical reaction) or PHOTOTROPHY (via light reaction); for chemotrophs by their source of chemical energy: CHEMOLITHOTROPHY (from inorganic compounds) or chemoorganotrophy (from organic compounds); and by their source for CARBON; NITROGEN; etc.; HETEROTROPHY (from organic sources) or AUTOTROPHY (from CARBON DIOXIDE). They can also be classified by whether or not they stain (based on the structure of their CELL WALLS) with CRYSTAL VIOLET dye: gram-negative or gram-positive.
Proteins isolated from the outer membrane of Gram-negative bacteria.
Beta-lactam antibiotics that differ from PENICILLINS in having the thiazolidine sulfur atom replaced by carbon, the sulfur then becoming the first atom in the side chain. They are unstable chemically, but have a very broad antibacterial spectrum. Thienamycin and its more stable derivatives are proposed for use in combinations with enzyme inhibitors.
Toxic substances formed in or elaborated by bacteria; they are usually proteins with high molecular weight and antigenicity; some are used as antibiotics and some to skin test for the presence of or susceptibility to certain diseases.
Any liquid or solid preparation made specifically for the growth, storage, or transport of microorganisms or other types of cells. The variety of media that exist allow for the culturing of specific microorganisms and cell types, such as differential media, selective media, test media, and defined media. Solid media consist of liquid media that have been solidified with an agent such as AGAR or GELATIN.
Vaccines or candidate vaccines used to prevent or treat PSEUDOMONAS INFECTIONS.
A group of beta-lactam antibiotics in which the sulfur atom in the thiazolidine ring of the penicillin molecule is replaced by a carbon atom. THIENAMYCINS are a subgroup of carbapenems which have a sulfur atom as the first constituent of the side chain.
The ability of bacteria to resist or to become tolerant to chemotherapeutic agents, antimicrobial agents, or antibiotics. This resistance may be acquired through gene mutation or foreign DNA in transmissible plasmids (R FACTORS).
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
A protease of broad specificity, obtained from dried pancreas. Molecular weight is approximately 25,000. The enzyme breaks down elastin, the specific protein of elastic fibers, and digests other proteins such as fibrin, hemoglobin, and albumin. EC 3.4.21.36.
Cyclic polypeptide antibiotic from Bacillus colistinus. It is composed of Polymyxins E1 and E2 (or Colistins A, B, and C) which act as detergents on cell membranes. Colistin is less toxic than Polymyxin B, but otherwise similar; the methanesulfonate is used orally.
A bacterial protein from Pseudomonas, Bordetella, or Alcaligenes which operates as an electron transfer unit associated with the cytochrome chain. The protein has a molecular weight of approximately 16,000, contains a single copper atom, is intensively blue, and has a fluorescence emission band centered at 308nm.
A broad-spectrum antimicrobial carboxyfluoroquinoline.
The ability of bacteria to resist or to become tolerant to several structurally and functionally distinct drugs simultaneously. This resistance may be acquired through gene mutation or foreign DNA in transmissible plasmids (R FACTORS).
A species of gram-negative bacteria in the genus PSEUDOMONAS, containing multiple genomovars. It is distinguishable from other pseudomonad species by its ability to use MALTOSE and STARCH as sole carbon and energy sources. It can degrade ENVIRONMENTAL POLLUTANTS and has been used as a model organism to study denitrification.
The degree of pathogenicity within a group or species of microorganisms or viruses as indicated by case fatality rates and/or the ability of the organism to invade the tissues of the host. The pathogenic capacity of an organism is determined by its VIRULENCE FACTORS.
A broad-spectrum antibiotic derived from KANAMYCIN. It is reno- and oto-toxic like the other aminoglycoside antibiotics.
Glycosylated compounds in which there is an amino substituent on the glycoside. Some of them are clinically important ANTIBIOTICS.
A semisynthetic ampicillin-derived acylureido penicillin.
Enumeration by direct count of viable, isolated bacterial, archaeal, or fungal CELLS or SPORES capable of growth on solid CULTURE MEDIA. The method is used routinely by environmental microbiologists for quantifying organisms in AIR; FOOD; and WATER; by clinicians for measuring patients' microbial load; and in antimicrobial drug testing.
Physicochemical property of fimbriated (FIMBRIAE, BACTERIAL) and non-fimbriated bacteria of attaching to cells, tissue, and nonbiological surfaces. It is a factor in bacterial colonization and pathogenicity.
Loss of epithelial tissue from the surface of the cornea due to progressive erosion and necrosis of the tissue; usually caused by bacterial, fungal, or viral infection.
A monocyclic beta-lactam antibiotic originally isolated from Chromobacterium violaceum. It is resistant to beta-lactamases and is used in gram-negative infections, especially of the meninges, bladder, and kidneys. It may cause a superinfection with gram-positive organisms.
Inflammation of the cornea.
Substances that prevent infectious agents or organisms from spreading or kill infectious agents in order to prevent the spread of infection.
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
Extrachromosomal, usually CIRCULAR DNA molecules that are self-replicating and transferable from one organism to another. They are found in a variety of bacterial, archaeal, fungal, algal, and plant species. They are used in GENETIC ENGINEERING as CLONING VECTORS.
Inflammation of the lung parenchyma that is caused by bacterial infections.
Material coughed up from the lungs and expectorated via the mouth. It contains MUCUS, cellular debris, and microorganisms. It may also contain blood or pus.
A species of gram-negative, facultatively anaerobic, rod-shaped bacteria (GRAM-NEGATIVE FACULTATIVELY ANAEROBIC RODS) commonly found in the lower part of the intestine of warm-blooded animals. It is usually nonpathogenic, but some strains are known to produce DIARRHEA and pyogenic infections. Pathogenic strains (virotypes) are classified by their specific pathogenic mechanisms such as toxins (ENTEROTOXIGENIC ESCHERICHIA COLI), etc.
A group of broad-spectrum antibiotics first isolated from the Mediterranean fungus ACREMONIUM. They contain the beta-lactam moiety thia-azabicyclo-octenecarboxylic acid also called 7-aminocephalosporanic acid.
Basic lipopeptide antibiotic group obtained from Bacillus polymyxa. They affect the cell membrane by detergent action and may cause neuromuscular and kidney damage. At least eleven different members of the polymyxin group have been identified, each designated by a letter.
Any infection which a patient contracts in a health-care institution.
The insertion of recombinant DNA molecules from prokaryotic and/or eukaryotic sources into a replicating vehicle, such as a plasmid or virus vector, and the introduction of the resultant hybrid molecules into recipient cells without altering the viability of those cells.
In bacteria, a group of metabolically related genes, with a common promoter, whose transcription into a single polycistronic MESSENGER RNA is under the control of an OPERATOR REGION.
Semisynthetic, broad-spectrum, AMPICILLIN derived ureidopenicillin antibiotic proposed for PSEUDOMONAS infections. It is also used in combination with other antibiotics.
Low-molecular-weight compounds produced by microorganisms that aid in the transport and sequestration of ferric iron. (The Encyclopedia of Molecular Biology, 1994)
Hydrogen cyanide (HCN); A toxic liquid or colorless gas. It is found in the smoke of various tobacco products and released by combustion of nitrogen-containing organic materials.
A test used to determine whether or not complementation (compensation in the form of dominance) will occur in a cell with a given mutant phenotype when another mutant genome, encoding the same mutant phenotype, is introduced into that cell.
A family of gram-negative, facultatively anaerobic, rod-shaped bacteria that do not form endospores. Its organisms are distributed worldwide with some being saprophytes and others being plant and animal parasites. Many species are of considerable economic importance due to their pathogenic effects on agriculture and livestock.
Any normal or abnormal coloring matter in PLANTS; ANIMALS or micro-organisms.
Bacteria which retain the crystal violet stain when treated by Gram's method.
Thin, hairlike appendages, 1 to 20 microns in length and often occurring in large numbers, present on the cells of gram-negative bacteria, particularly Enterobacteriaceae and Neisseria. Unlike flagella, they do not possess motility, but being protein (pilin) in nature, they possess antigenic and hemagglutinating properties. They are of medical importance because some fimbriae mediate the attachment of bacteria to cells via adhesins (ADHESINS, BACTERIAL). Bacterial fimbriae refer to common pili, to be distinguished from the preferred use of "pili", which is confined to sex pili (PILI, SEX).
Invasion of the site of trauma by pathogenic microorganisms.
Proteins that are structural components of bacterial fimbriae (FIMBRIAE, BACTERIAL) or sex pili (PILI, SEX).
Polysaccharides found in bacteria and in capsules thereof.
A multistage process that includes cloning, physical mapping, subcloning, determination of the DNA SEQUENCE, and information analysis.
Antibiotic complex produced by Streptomyces kanamyceticus from Japanese soil. Comprises 3 components: kanamycin A, the major component, and kanamycins B and C, the minor components.
Lipid-containing polysaccharides which are endotoxins and important group-specific antigens. They are often derived from the cell wall of gram-negative bacteria and induce immunoglobulin secretion. The lipopolysaccharide molecule consists of three parts: LIPID A, core polysaccharide, and O-specific chains (O ANTIGENS). When derived from Escherichia coli, lipopolysaccharides serve as polyclonal B-cell mitogens commonly used in laboratory immunology. (From Dorland, 28th ed)
Injuries to tissues caused by contact with heat, steam, chemicals (BURNS, CHEMICAL), electricity (BURNS, ELECTRIC), or the like.
Porins are protein molecules that were originally found in the outer membrane of GRAM-NEGATIVE BACTERIA and that form multi-meric channels for the passive DIFFUSION of WATER; IONS; or other small molecules. Porins are present in bacterial CELL WALLS, as well as in plant, fungal, mammalian and other vertebrate CELL MEMBRANES and MITOCHONDRIAL MEMBRANES.
Four-membered cyclic AMIDES, best known for the PENICILLINS based on a bicyclo-thiazolidine, as well as the CEPHALOSPORINS based on a bicyclo-thiazine, and including monocyclic MONOBACTAMS. The BETA-LACTAMASES hydrolyze the beta lactam ring, accounting for BETA-LACTAM RESISTANCE of infective bacteria.
An antibiotic derived from penicillin similar to CARBENICILLIN in action.
A group of derivatives of naphthyridine carboxylic acid, quinoline carboxylic acid, or NALIDIXIC ACID.
Cyclic esters of acylated BUTYRIC ACID containing four carbons in the ring.
Infections by bacteria, general or unspecified.
Infections caused by bacteria that show up as pink (negative) when treated by the gram-staining method.
A species of BURKHOLDERIA considered to be an opportunistic human pathogen. It has been associated with various types of infections of nosocomial origin.
A parasexual process in BACTERIA; ALGAE; FUNGI; and ciliate EUKARYOTA for achieving exchange of chromosome material during fusion of two cells. In bacteria, this is a uni-directional transfer of genetic material; in protozoa it is a bi-directional exchange. In algae and fungi, it is a form of sexual reproduction, with the union of male and female gametes.
Potentially pathogenic bacteria found in nasal membranes, skin, hair follicles, and perineum of warm-blooded animals. They may cause a wide range of infections and intoxications.
A protein with a molecular weight of 40,000 isolated from bacterial flagella. At appropriate pH and salt concentration, three flagellin monomers can spontaneously reaggregate to form structures which appear identical to intact flagella.
Mutagenesis where the mutation is caused by the introduction of foreign DNA sequences into a gene or extragenic sequence. This may occur spontaneously in vivo or be experimentally induced in vivo or in vitro. Proviral DNA insertions into or adjacent to a cellular proto-oncogene can interrupt GENETIC TRANSLATION of the coding sequences or interfere with recognition of regulatory elements and cause unregulated expression of the proto-oncogene resulting in tumor formation.
Either of the pair of organs occupying the cavity of the thorax that effect the aeration of the blood.
Ability of a microbe to survive under given conditions. This can also be related to a colony's ability to replicate.
Discrete segments of DNA which can excise and reintegrate to another site in the genome. Most are inactive, i.e., have not been found to exist outside the integrated state. DNA transposable elements include bacterial IS (insertion sequence) elements, Tn elements, the maize controlling elements Ac and Ds, Drosophila P, gypsy, and pogo elements, the human Tigger elements and the Tc and mariner elements which are found throughout the animal kingdom.
The restriction of a characteristic behavior, anatomical structure or physical system, such as immune response; metabolic response, or gene or gene variant to the members of one species. It refers to that property which differentiates one species from another but it is also used for phylogenetic levels higher or lower than the species.
A mixture of polymyxins B1 and B2, obtained from Bacillus polymyxa strains. They are basic polypeptides of about eight amino acids and have cationic detergent action on cell membranes. Polymyxin B is used for infections with gram-negative organisms, but may be neurotoxic and nephrotoxic.
A group of antibiotics that contain 6-aminopenicillanic acid with a side chain attached to the 6-amino group. The penicillin nucleus is the chief structural requirement for biological activity. The side-chain structure determines many of the antibacterial and pharmacological characteristics. (Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed, p1065)
Immunoglobulins produced in a response to BACTERIAL ANTIGENS.
A protein which is a subunit of RNA polymerase. It effects initiation of specific RNA chains from DNA.
Reversibly catalyze the oxidation of a hydroxyl group of carbohydrates to form a keto sugar, aldehyde or lactone. Any acceptor except molecular oxygen is permitted. Includes EC 1.1.1.; EC 1.1.2.; and 1.1.99.
Viruses whose hosts are bacterial cells.
Elimination of ENVIRONMENTAL POLLUTANTS; PESTICIDES and other waste using living organisms, usually involving intervention of environmental or sanitation engineers.
Nonsusceptibility of bacteria to the action of the beta-lactam antibiotics. Mechanisms responsible for beta-lactam resistance may be degradation of antibiotics by BETA-LACTAMASES, failure of antibiotics to penetrate, or low-affinity binding of antibiotics to targets.
Any compound containing one or more monosaccharide residues bound by a glycosidic linkage to a hydrophobic moiety such as an acylglycerol (see GLYCERIDES), a sphingoid, a ceramide (CERAMIDES) (N-acylsphingoid) or a prenyl phosphate. (From IUPAC's webpage)
Oxidases that specifically introduce DIOXYGEN-derived oxygen atoms into a variety of organic molecules.
The degree of similarity between sequences of amino acids. This information is useful for the analyzing genetic relatedness of proteins and species.
The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment.
The lipopolysaccharide-protein somatic antigens, usually from gram-negative bacteria, important in the serological classification of enteric bacilli. The O-specific chains determine the specificity of the O antigens of a given serotype. O antigens are the immunodominant part of the lipopolysaccharide molecule in the intact bacterial cell. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)
A building block of penicillin, devoid of significant antibacterial activity. (From Merck Index, 11th ed)
Techniques used in studying bacteria.
A genus of gram-negative bacteria of the family MORAXELLACEAE, found in soil and water and of uncertain pathogenicity.
Cyclic AMIDES formed from aminocarboxylic acids by the elimination of water. Lactims are the enol forms of lactams.
Membrane proteins whose primary function is to facilitate the transport of molecules across a biological membrane. Included in this broad category are proteins involved in active transport (BIOLOGICAL TRANSPORT, ACTIVE), facilitated transport and ION CHANNELS.
Structures within the nucleus of bacterial cells consisting of or containing DNA, which carry genetic information essential to the cell.
The rate dynamics in chemical or physical systems.
A metallic element with atomic symbol Fe, atomic number 26, and atomic weight 55.85. It is an essential constituent of HEMOGLOBINS; CYTOCHROMES; and IRON-BINDING PROTEINS. It plays a role in cellular redox reactions and in the transport of OXYGEN.
A sub-class of PEPTIDE HYDROLASES that act only near the ends of polypeptide chains.
The presence of viable bacteria circulating in the blood. Fever, chills, tachycardia, and tachypnea are common acute manifestations of bacteremia. The majority of cases are seen in already hospitalized patients, most of whom have underlying diseases or procedures which render their bloodstreams susceptible to invasion.
A genetic rearrangement through loss of segments of DNA or RNA, bringing sequences which are normally separated into close proximity. This deletion may be detected using cytogenetic techniques and can also be inferred from the phenotype, indicating a deletion at one specific locus.
A group of enzymes that catalyze an intramolecular transfer of a phosphate group. It has been shown in some cases that the enzyme has a functional phosphate group, which can act as the donor. These were previously listed under PHOSPHOTRANSFERASES (EC 2.7.-). (From Enzyme Nomenclature, 1992) EC 5.4.2.
The generic name for the group of aliphatic hydrocarbons Cn-H2n+2. They are denoted by the suffix -ane. (Grant & Hackh's Chemical Dictionary, 5th ed)
Use of restriction endonucleases to analyze and generate a physical map of genomes, genes, or other segments of DNA.
A synthetic fluoroquinolone (FLUOROQUINOLONES) with broad-spectrum antibacterial activity against most gram-negative and gram-positive bacteria. Norfloxacin inhibits bacterial DNA GYRASE.
A natural association between organisms that is detrimental to at least one of them. This often refers to the production of chemicals by one microorganism that is harmful to another.
A group of QUINOLONES with at least one fluorine atom and a piperazinyl group.
The presence of an infectious agent on instruments, prostheses, or other inanimate articles.
A pyridinium-substituted semisynthetic, broad-spectrum antibacterial used especially for Pseudomonas infections in debilitated patients.
A whiplike motility appendage present on the surface cells. Prokaryote flagella are composed of a protein called FLAGELLIN. Bacteria can have a single flagellum, a tuft at one pole, or multiple flagella covering the entire surface. In eukaryotes, flagella are threadlike protoplasmic extensions used to propel flagellates and sperm. Flagella have the same basic structure as CILIA but are longer in proportion to the cell bearing them and present in much smaller numbers. (From King & Stansfield, A Dictionary of Genetics, 4th ed)
The genetic complement of a BACTERIA as represented in its DNA.
Pathological processes involving any part of the LUNG.
DNA elements that include the component genes and insertion site for a site-specific recombination system that enables them to capture mobile gene cassettes.
Ribonucleic acid in bacteria having regulatory and catalytic roles as well as involvement in protein synthesis.
A class of plasmids that transfer antibiotic resistance from one bacterium to another by conjugation.
The complete absence, or (loosely) the paucity, of gaseous or dissolved elemental oxygen in a given place or environment. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)
A synthetic fluoroquinolone antibacterial agent that inhibits the supercoiling activity of bacterial DNA GYRASE, halting DNA REPLICATION.
Gel electrophoresis in which the direction of the electric field is changed periodically. This technique is similar to other electrophoretic methods normally used to separate double-stranded DNA molecules ranging in size up to tens of thousands of base-pairs. However, by alternating the electric field direction one is able to separate DNA molecules up to several million base-pairs in length.
Gram-negative, non-motile, capsulated, gas-producing rods found widely in nature and associated with urinary and respiratory infections in humans.
Benzoic acid or benzoic acid esters substituted with one or more chlorine atoms.
Inflammation of the lung parenchyma that is associated with BRONCHITIS, usually involving lobular areas from TERMINAL BRONCHIOLES to the PULMONARY ALVEOLI. The affected areas become filled with exudate that forms consolidated patches.
An enzyme that catalyzes the reversible isomerization of D-mannose-6-phosphate to form D-fructose-6-phosphate, an important step in glycolysis. EC 5.3.1.8.
The action of a drug in promoting or enhancing the effectiveness of another drug.
A characteristic feature of enzyme activity in relation to the kind of substrate on which the enzyme or catalytic molecule reacts.
Persistent abnormal dilatation of the bronchi.
Substances used on inanimate objects that destroy harmful microorganisms or inhibit their activity. Disinfectants are classed as complete, destroying SPORES as well as vegetative forms of microorganisms, or incomplete, destroying only vegetative forms of the organisms. They are distinguished from ANTISEPTICS, which are local anti-infective agents used on humans and other animals. (From Hawley's Condensed Chemical Dictionary, 11th ed)
Electrophoresis in which a polyacrylamide gel is used as the diffusion medium.
Invasion of the host RESPIRATORY SYSTEM by microorganisms, usually leading to pathological processes or diseases.
Non-heme iron-containing enzymes that incorporate two atoms of OXYGEN into the substrate. They are important in biosynthesis of FLAVONOIDS; GIBBERELLINS; and HYOSCYAMINE; and for degradation of AROMATIC HYDROCARBONS.
Monocyclic, bacterially produced or semisynthetic beta-lactam antibiotics. They lack the double ring construction of the traditional beta-lactam antibiotics and can be easily synthesized.
Systemic inflammatory response syndrome with a proven or suspected infectious etiology. When sepsis is associated with organ dysfunction distant from the site of infection, it is called severe sepsis. When sepsis is accompanied by HYPOTENSION despite adequate fluid infusion, it is called SEPTIC SHOCK.
A species of gram-negative bacteria in the genus PSEUDOMONAS, which is found in SOIL and WATER.
A complex sulfated polymer of galactose units, extracted from Gelidium cartilagineum, Gracilaria confervoides, and related red algae. It is used as a gel in the preparation of solid culture media for microorganisms, as a bulk laxative, in making emulsions, and as a supporting medium for immunodiffusion and immunoelectrophoresis.
The engulfing and degradation of microorganisms; other cells that are dead, dying, or pathogenic; and foreign particles by phagocytic cells (PHAGOCYTES).
Catalyzes the oxidation of catechol to 2-hydroxymuconate semialdehyde in the carbazole and BENZOATE degradation via HYDROXYLATION pathways. It also catalyzes the conversion of 3-methylcatechol to cis, cis-2-hydroxy-6-oxohept-2,4-dienoate in the TOLUENE and XYLENE degradation pathway. This enzyme was formerly characterized as EC 1.13.1.2.
A methylpentose whose L- isomer is found naturally in many plant glycosides and some gram-negative bacterial lipopolysaccharides.
The presence of bacteria, viruses, and fungi in the soil. This term is not restricted to pathogenic organisms.
The space between the inner and outer membranes of a cell that is shared with the cell wall.
The sum of the weight of all the atoms in a molecule.
The normality of a solution with respect to HYDROGEN ions; H+. It is related to acidity measurements in most cases by pH = log 1/2[1/(H+)], where (H+) is the hydrogen ion concentration in gram equivalents per liter of solution. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)
Peptides composed of between two and twelve amino acids.
Process of determining and distinguishing species of bacteria or viruses based on antigens they share.
Semisynthetic broad-spectrum cephalosporin with a tetrazolyl moiety that is resistant to beta-lactamase. It has been proposed especially against Pseudomonas infections.
A set of genes descended by duplication and variation from some ancestral gene. Such genes may be clustered together on the same chromosome or dispersed on different chromosomes. Examples of multigene families include those that encode the hemoglobins, immunoglobulins, histocompatibility antigens, actins, tubulins, keratins, collagens, heat shock proteins, salivary glue proteins, chorion proteins, cuticle proteins, yolk proteins, and phaseolins, as well as histones, ribosomal RNA, and transfer RNA genes. The latter three are examples of reiterated genes, where hundreds of identical genes are present in a tandem array. (King & Stanfield, A Dictionary of Genetics, 4th ed)
Diffusible gene products that act on homologous or heterologous molecules of viral or cellular DNA to regulate the expression of proteins.
A group of enzymes that oxidize diverse nitrogenous substances to yield nitrite. (Enzyme Nomenclature, 1992) EC 1.
Nonsusceptibility of an organism to the action of penicillins.
Measurable quantity of bacteria in an object, organism, or organism compartment.
QUINOLONES containing a 4-oxo (a carbonyl in the para position to the nitrogen). They inhibit the A subunit of DNA GYRASE and are used as antimicrobials. Second generation 4-quinolones are also substituted with a 1-piperazinyl group at the 7-position and a fluorine at the 6-position.
Granular leukocytes having a nucleus with three to five lobes connected by slender threads of chromatin, and cytoplasm containing fine inconspicuous granules and stainable by neutral dyes.
A species of gram-negative, aerobic bacteria, commonly found in the clinical laboratory, and frequently resistant to common antibiotics.
The biosynthesis of RNA carried out on a template of DNA. The biosynthesis of DNA from an RNA template is called REVERSE TRANSCRIPTION.
Benzene derivatives that include one or more hydroxyl groups attached to the ring structure.
A genus of gram-negative, facultatively anaerobic, rod-shaped bacteria occurring in soil and water. Its organisms are generally nonpathogenic, but some species do cause infections of mammals, including humans.
Inflammation of the OUTER EAR including the external EAR CANAL, cartilages of the auricle (EAR CARTILAGE), and the TYMPANIC MEMBRANE.
A group of 1,2-benzenediols that contain the general formula R-C6H5O2.
Substances elaborated by specific strains of bacteria that are lethal against other strains of the same or related species. They are protein or lipopolysaccharide-protein complexes used in taxonomy studies of bacteria.
Diseases of plants.
Life or metabolic reactions occurring in an environment containing oxygen.
The natural bactericidal property of BLOOD due to normally occurring antibacterial substances such as beta lysin, leukin, etc. This activity needs to be distinguished from the bactericidal activity contained in a patient's serum as a result of antimicrobial therapy, which is measured by a SERUM BACTERICIDAL TEST.
Inflammation of follicles, primarily hair follicles.
The class of all enzymes catalyzing oxidoreduction reactions. The substrate that is oxidized is regarded as a hydrogen donor. The systematic name is based on donor:acceptor oxidoreductase. The recommended name will be dehydrogenase, wherever this is possible; as an alternative, reductase can be used. Oxidase is only used in cases where O2 is the acceptor. (Enzyme Nomenclature, 1992, p9)
Community of tiny aquatic PLANTS and ANIMALS, and photosynthetic BACTERIA, that are either free-floating or suspended in the water, with little or no power of locomotion. They are divided into PHYTOPLANKTON and ZOOPLANKTON.
Hydrolases that specifically cleave the peptide bonds found in PROTEINS and PEPTIDES. Examples of sub-subclasses for this group include EXOPEPTIDASES and ENDOPEPTIDASES.
In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.
The property of objects that determines the direction of heat flow when they are placed in direct thermal contact. The temperature is the energy of microscopic motions (vibrational and translational) of the particles of atoms.
A widely used industrial solvent.
Small cationic peptides that are an important component, in most species, of early innate and induced defenses against invading microbes. In animals they are found on mucosal surfaces, within phagocytic granules, and on the surface of the body. They are also found in insects and plants. Among others, this group includes the DEFENSINS, protegrins, tachyplesins, and thionins. They displace DIVALENT CATIONS from phosphate groups of MEMBRANE LIPIDS leading to disruption of the membrane.
Cells that line the inner and outer surfaces of the body by forming cellular layers (EPITHELIUM) or masses. Epithelial cells lining the SKIN; the MOUTH; the NOSE; and the ANAL CANAL derive from ectoderm; those lining the RESPIRATORY SYSTEM and the DIGESTIVE SYSTEM derive from endoderm; others (CARDIOVASCULAR SYSTEM and LYMPHATIC SYSTEM) derive from mesoderm. Epithelial cells can be classified mainly by cell shape and function into squamous, glandular and transitional epithelial cells.
Models used experimentally or theoretically to study molecular shape, electronic properties, or interactions; includes analogous molecules, computer-generated graphics, and mechanical structures.
Genes which regulate or circumscribe the activity of other genes; specifically, genes which code for PROTEINS or RNAs which have GENE EXPRESSION REGULATION functions.
Simultaneous resistance to several structurally and functionally distinct drugs.

UK-18892, a new aminoglycoside: an in vitro study. (1/9595)

UK-18892 is a new aminoglycoside antibiotic, a derivative of kanamycin A structurally related to amikacin. It was found to be active against a wide range of pathogenic bacteria, including many gentamicin-resistant strains. The spectrum and degree of activity of UK-18892 were similar to those of amikacin, and differences were relatively minor. UK-18892 was about twice as active as amikacin against gentamicin-susceptible strains of Pseudomonas aeruginosa. Both amikacin and UK-18892 were equally active against gentamicin-resistant strains of P. aeruginosa. There were no appreciable differences in the activity of UK-18892 and amikacin against Enterobacteriaceae and Staphylococcus aureus. Cross-resistance between these two antimicrobials was also apparent.  (+info)

Modified peptidoglycan transpeptidase activity in a carbenicillin-resistant mutant of Pseudomonas aeruginosa 18s. (2/9595)

A carbenicillin-resistant mutant of Pseudomonas aeruginosa 18s was found to possess peptidoglycan transpeptidase activity significantly more resistant to inhibition by benzyl penicillin, ampicillin, carbenicillin, and cephaloridine than that of the parent strain. The mutant was more resistant than the parent strain to all of the beta-lactam antibiotics tested, and 50% inhibition values for these compounds against membrane-bound model transpeptidase activity paralleled this increase. The resistance of the mutant to kanamycin, streptomycin, and chloramphenicol was unchanged.  (+info)

Improved medium for recovery and enumeration of Pseudomonas aeruginosa from water using membrane filters. (3/9595)

A modified mPA medium, designated mPA-C, was shown to recover Pseudomonas aeruginosa from a variety of water sources with results comparable to those with mPA-B and within the confidence limits of a most-probable-number technique. Enumeration of P. aeruginosa on mPA-C was possible after only 24 h of incubation at 41.5 degrees C, compared with 72 h of incubation required for mPA-B and 96 h of incubation for a presumptive most probable number.  (+info)

Automated food microbiology: potential for the hydrophobic grid-membrane filter. (4/9595)

Bacterial counts obtained on hydrophobic grid-membrane filters were comparable to conventional plate counts for Pseudomonas aeruginosa, Escherichia coli, and Staphylococcus aureus in homogenates from a range of foods. The wide numerical operating range of the hydrophobic grid-membrane filters allowed sequential diluting to be reduced or even eliminated, making them attractive as components in automated systems of analysis. Food debris could be rinsed completely from the unincubated hydrophobic grid-membrane filter surface without affecting the subsequent count, thus eliminating the possibility of counting food particles, a common source of error in electronic counting systems.  (+info)

Denitrifying Pseudomonas aeruginosa: some parameters of growth and active transport. (5/9595)

Optimal cell yield of Pseudomonas aeruginosa grown under denitrifying conditions was obtained with 100 mM nitrate as the terminal electron acceptor, irrespective of the medium used. Nitrite as the terminal electron acceptor supported poor denitrifying growth when concentrations of less than 15 mM, but not higher, were used, apparently owing to toxicity exerted by nitrite. Nitrite accumulated in the medium during early exponential phase when nitrate was the terminal electron acceptor and then decreased to extinction before midexponential phase. The maximal rate of glucose and gluconate transport was supported by 1 mM nitrate or nitrite as the terminal electron acceptor under anaerobic conditions. The transport rate was greater with nitrate than with nitrite as the terminal electron acceptor, but the greatest transport rate was observed under aerobic conditions with oxygen as the terminal electron acceptor. When P. aeruginosa was inoculated into a denitrifying environment, nitrate reductase was detected after 3 h of incubation, nitrite reductase was detected after another 4 h of incubation, and maximal nitrate and nitrite reductase activities peaked together during midexponential phase. The latter coincided with maximal glucose transport activity.  (+info)

The Pseudomonas aeruginosa secretory product pyocyanin inactivates alpha1 protease inhibitor: implications for the pathogenesis of cystic fibrosis lung disease. (6/9595)

Alpha1 Protease inhibitor (alpha1PI) modulates serine protease activity in the lung. Reactive oxygen species inactivate alpha1PI, and this process has been implicated in the pathogenesis of a variety of forms of lung injury. An imbalance of protease-antiprotease activity is also detected in the airways of patients with cystic fibrosis-associated lung disease who are infected with Pseudomonas aeruginosa. P. aeruginosa secretes pyocyanin, which, through its ability to redox cycle, induces cells to generate reactive oxygen species. We tested the hypothesis that redox cycling of pyocyanin could lead to inactivation of alpha1PI. When alpha1PI was exposed to NADH and pyocyanin, a combination that results in superoxide production, alpha1PI lost its ability to form an inhibitory complex with both porcine pancreatic elastase (PPE) and trypsin. Similarly, addition of pyocyanin to cultures of human airway epithelial cells to which alpha1PI was also added resulted in a loss of the ability of alpha1PI to form a complex with PPE or trypsin. Neither superoxide dismutase, catalase, nor dimethylthiourea nor depletion of the media of O2 to prevent formation of reactive oxygen species blocked pyocyanin-mediated inactivation of alpha1PI. These data raise the possibility that a direct interaction between reduced pyocyanin and alpha1PI is involved in the process. Consistent with this possibility, pretreatment of alpha1PI with the reducing agent beta-mercaptoethanol also inhibited binding of trypsin to alpha1PI. These data suggest that pyocyanin could contribute to lung injury in the P. aeruginosa-infected airway of cystic fibrosis patients by decreasing the ability of alpha1PI to control the local activity of serine proteases.  (+info)

Safety and immunogenicity of a Pseudomonas aeruginosa hybrid outer membrane protein F-I vaccine in human volunteers. (7/9595)

A hybrid protein [Met-Ala-(His)6OprF190-342-OprI21-83] consisting of the mature outer membrane protein I (OprI) and amino acids 190 to 342 of OprF of Pseudomonas aeruginosa was expressed in Escherichia coli and purified by Ni2+ chelate-affinity chromatography. After safety and pyrogenicity evaluations in animals, four groups of eight adult human volunteers were vaccinated intramuscularly three times at 4-week intervals and revaccinated 6 months later with either 500, 100, 50, or 20 microg of OprF-OprI adsorbed onto A1(OH)3. All vaccinations were well tolerated. After the first vaccination, a significant rise of antibody titers against P. aeruginosa OprF and OprI was measured in volunteers receiving the 100- or the 500-microg dose. After the second vaccination, significant antibody titers were measured for all groups. Elevated antibody titers against OprF and OprI could still be measured 6 months after the third vaccination. The capacity of the elicited antibodies to promote complement binding and opsonization could be demonstrated by a C1q-binding assay and by the in vitro opsonophagocytic uptake of P. aeruginosa bacteria. These data support the continued development of an OprF-OprI vaccine for use in humans.  (+info)

Lipopolysaccharide (LPS) from Burkholderia cepacia is more active than LPS from Pseudomonas aeruginosa and Stenotrophomonas maltophilia in stimulating tumor necrosis factor alpha from human monocytes. (8/9595)

Whole cells and lipopolysaccharides (LPSs) extracted from Burkholderia cepacia, Pseudomonas aeruginosa, Stenotrophomonas maltophilia, and Escherichia coli were compared in their ability to stimulate tumor necrosis factor alpha (TNF-alpha) from the human monocyte cell line MonoMac-6. B. cepacia LPS, on a weight-for-weight basis, was found to have TNF-alpha-inducing activity similar to that of LPS from E. coli, which was approximately four- and eightfold greater than the activity of LPSs from P. aeruginosa and S. maltophilia, respectively. The LPS-stimulated TNF-alpha production from monocytes was found to be CD14 dependent. These results suggest that B. cepacia LPS might play a role in the pathogenesis of inflammatory lung disease in cystic fibrosis, and in some patients it might be responsible, at least in part, for the sepsis-like cepacia syndrome.  (+info)

Pseudomonas infections are challenging to treat due to the bacteria's ability to develop resistance against antibiotics. The treatment typically involves a combination of antibiotics and other supportive therapies, such as oxygen therapy or mechanical ventilation, to manage symptoms and prevent complications. In some cases, surgical intervention may be necessary to remove infected tissue or repair damaged organs.

Symptoms of cystic fibrosis can vary from person to person, but may include:

* Persistent coughing and wheezing
* Thick, sticky mucus that clogs airways and can lead to respiratory infections
* Difficulty gaining weight or growing at the expected rate
* Intestinal blockages or digestive problems
* Fatty stools
* Nausea and vomiting
* Diarrhea
* Rectal prolapse
* Increased risk of liver disease and respiratory failure

Cystic fibrosis is usually diagnosed in infancy, and treatment typically includes a combination of medications, respiratory therapy, and other supportive care. Management of the disease focuses on controlling symptoms, preventing complications, and improving quality of life. With proper treatment and care, many people with cystic fibrosis can lead long, fulfilling lives.

In summary, cystic fibrosis is a genetic disorder that affects the respiratory, digestive, and reproductive systems, causing thick and sticky mucus to build up in these organs, leading to serious health problems. It can be diagnosed in infancy and managed with a combination of medications, respiratory therapy, and other supportive care.

1. Conjunctivitis: This is an infection of the conjunctiva, which is the thin membrane that covers the white part of the eye and the inside of the eyelids. It is often caused by Streptococcus pneumoniae or Haemophilus influenzae bacteria.
2. Corneal ulcers: These are open sores that develop on the surface of the cornea, which is the clear dome-shaped surface at the front of the eye. Corneal ulcers can be caused by a variety of bacteria, including Staphylococcus aureus and Streptococcus pyogenes.
3. Endophthalmitis: This is an infection that occurs inside the eye, often as a complication of cataract surgery or other types of ocular surgery. It can be caused by a variety of bacteria, including Staphylococcus aureus and Streptococcus epidermidis.
4. Keratitis: This is an infection of the cornea that can be caused by a variety of bacteria, including Pseudomonas aeruginosa and Acinetobacter baumannii.
5. Retinitis: This is an infection of the retina, which is the layer of tissue at the back of the eye that senses light and sends visual signals to the brain. Retinitis can be caused by a variety of bacteria, including Haemophilus influenzae and Streptococcus pneumoniae.

Bacterial eye infections can cause a range of symptoms, including redness, swelling, discharge, pain, and blurred vision. Treatment typically involves antibiotic eye drops or ointments, and in more severe cases, oral antibiotics may be prescribed. It is important to seek medical attention if you experience any symptoms of a bacterial eye infection, as early treatment can help prevent complications and improve outcomes.

The symptoms of a corneal ulcer may include:

* Pain or discomfort in the eye
* Redness and swelling of the eye
* Discharge or pus in the eye
* Blurred vision or sensitivity to light
* A feeling that there is something in the eye

If left untreated, a corneal ulcer can lead to complications such as:

* Perforation of the cornea
* Inflammation of the iris (iritis)
* Inflammation of the retina (retinitis)
* Vision loss or blindness

Treatment of a corneal ulcer typically involves antibiotic eye drops or ointments to treat any underlying bacterial infection, as well as supportive care to manage pain and promote healing. In severe cases, surgery may be necessary to remove the damaged tissue and promote healing.

Prevention of corneal ulcers includes good hygiene, proper use of contact lenses, and avoiding touching or rubbing the eyes. Early detection and treatment are key to preventing complications and preserving vision.

Also known as: Corneal inflammation, Eye inflammation, Keratoconjunctivitis, Ocular inflammation.

The most common bacteria that cause pneumonia are Streptococcus pneumoniae (also known as pneumococcus), Haemophilus influenzae, and Staphylococcus aureus. These bacteria can infect the lungs through various routes, including respiratory droplets, contaminated food or water, or direct contact with an infected person.

Symptoms of pneumonia may include cough, fever, chills, shortness of breath, and chest pain. In severe cases, pneumonia can lead to serious complications such as respiratory failure, sepsis, and death.

Diagnosis of pneumonia typically involves a physical examination, medical history, and diagnostic tests such as chest X-rays or blood cultures. Treatment typically involves antibiotics to eliminate the infection, as well as supportive care to manage symptoms and prevent complications. Vaccines are also available to protect against certain types of bacterial pneumonia, particularly in children and older adults.

Preventative measures for bacterial pneumonia include:

* Getting vaccinated against Streptococcus pneumoniae and Haemophilus influenzae type b (Hib)
* Practicing good hygiene, such as washing hands regularly and covering the mouth and nose when coughing or sneezing
* Avoiding close contact with people who are sick
* Staying hydrated and getting enough rest
* Quitting smoking, if applicable
* Managing underlying medical conditions, such as diabetes or heart disease

It is important to seek medical attention promptly if symptoms of pneumonia develop, particularly in high-risk populations. Early diagnosis and treatment can help prevent serious complications and improve outcomes for patients with bacterial pneumonia.

In medicine, cross-infection refers to the transmission of an infectious agent from one individual or source to another, often through direct contact or indirect exposure. This type of transmission can occur in various settings, such as hospitals, clinics, and long-term care facilities, where patients with compromised immune systems are more susceptible to infection.

Cross-infection can occur through a variety of means, including:

1. Person-to-person contact: Direct contact with an infected individual, such as touching, hugging, or shaking hands.
2. Contaminated surfaces and objects: Touching contaminated surfaces or objects that have been touched by an infected individual, such as doorknobs, furniture, or medical equipment.
3. Airborne transmission: Inhaling droplets or aerosolized particles that contain the infectious agent, such as during coughing or sneezing.
4. Contaminated food and water: Consuming food or drinks that have been handled by an infected individual or contaminated with the infectious agent.
5. Insect vectors: Mosquitoes, ticks, or other insects can transmit infections through their bites.

Cross-infection is a significant concern in healthcare settings, as it can lead to outbreaks of nosocomial infections (infections acquired in hospitals) and can spread rapidly among patients, healthcare workers, and visitors. To prevent cross-infection, healthcare providers use strict infection control measures, such as wearing personal protective equipment (PPE), thoroughly cleaning and disinfecting surfaces, and implementing isolation precautions for infected individuals.

In summary, cross-infection refers to the transmission of an infectious agent from one individual or source to another, often through direct contact or indirect exposure in healthcare settings. Preventing cross-infection is essential to maintaining a safe and healthy environment for patients, healthcare workers, and visitors.

Symptoms of wound infection may include:

* Redness, swelling, or increased pain around the wound
* Increased drainage or pus from the wound
* Bad smell or discharge from the wound
* Fever or chills
* Swollen lymph nodes

Treatment of wound infection usually involves antibiotics and may require surgical intervention to remove infected tissue. It is important to practice good wound care, such as keeping the wound clean and dry, changing dressings regularly, and monitoring for signs of infection to prevent the development of a wound infection.

Preventive measures include:

* Proper sterilization and technique during surgery or medical procedures
* Keeping the wound site clean and dry
* Removing any dead tissue or debris from the wound
* Using antibiotic ointment or cream to prevent infection
* Covering the wound with a sterile dressing

If you suspect that you have a wound infection, it is important to seek medical attention as soon as possible. A healthcare professional can evaluate the wound and provide appropriate treatment to prevent further complications.

First-degree burns are the mildest form of burn and affect only the outer layer of the skin. They are characterized by redness, swelling, and pain but do not blister or scar. Examples of first-degree burns include sunburns and minor scalds from hot liquids.

Second-degree burns are more severe and affect both the outer and inner layers of the skin. They can cause blisters, redness, swelling, and pain, and may lead to infection. Second-degree burns can be further classified into two subtypes: partial thickness burns (where the skin is damaged but not completely destroyed) and full thickness burns (where the skin is completely destroyed).

Third-degree burns are the most severe and affect all layers of the skin and underlying tissues. They can cause charring of the skin, loss of function, and may lead to infection or even death.

There are several ways to treat burns, including:

1. Cooling the burn with cool water or a cold compress to reduce heat and prevent further damage.
2. Keeping the burn clean and dry to prevent infection.
3. Applying topical creams or ointments to help soothe and heal the burn.
4. Taking pain medication to manage discomfort.
5. In severe cases, undergoing surgery to remove damaged tissue and promote healing.

Prevention is key when it comes to burns. Some ways to prevent burns include:

1. Being cautious when handling hot objects or substances.
2. Keeping a safe distance from open flames or sparks.
3. Wearing protective clothing, such as gloves and long sleeves, when working with hot materials.
4. Keeping children away from hot surfaces and substances.
5. Installing smoke detectors and fire extinguishers in the home to reduce the risk of fires.

Overall, burns can be a serious condition that requires prompt medical attention. By understanding the causes, symptoms, and treatments for burns, individuals can take steps to prevent them and seek help if they do occur.

Some common examples of bacterial infections include:

1. Urinary tract infections (UTIs)
2. Respiratory infections such as pneumonia and bronchitis
3. Skin infections such as cellulitis and abscesses
4. Bone and joint infections such as osteomyelitis
5. Infected wounds or burns
6. Sexually transmitted infections (STIs) such as chlamydia and gonorrhea
7. Food poisoning caused by bacteria such as salmonella and E. coli.

In severe cases, bacterial infections can lead to life-threatening complications such as sepsis or blood poisoning. It is important to seek medical attention if symptoms persist or worsen over time. Proper diagnosis and treatment can help prevent these complications and ensure a full recovery.

Gram-negative bacterial infections can be difficult to treat because these bacteria are resistant to many antibiotics. In addition, some gram-negative bacteria produce enzymes called beta-lactamases, which break down the penicillin ring of many antibiotics, making them ineffective against the infection.

Some common types of gram-negative bacterial infections include:

* Pneumonia
* Urinary tract infections (UTIs)
* Bloodstream infections (sepsis)
* Meningitis
* Skin and soft tissue infections
* Respiratory infections, such as bronchitis and sinusitis

Examples of gram-negative bacteria that can cause infection include:

* Escherichia coli (E. coli)
* Klebsiella pneumoniae
* Pseudomonas aeruginosa
* Acinetobacter baumannii
* Proteus mirabilis

Gram-negative bacterial infections can be diagnosed through a variety of tests, including blood cultures, urine cultures, and tissue samples. Treatment typically involves the use of broad-spectrum antibiotics, such as carbapenems or cephalosporins, which are effective against many types of gram-negative bacteria. In some cases, the infection may require hospitalization and intensive care to manage complications such as sepsis or organ failure.

Prevention of gram-negative bacterial infections includes good hand hygiene, proper use of personal protective equipment (PPE), and appropriate use of antibiotics. In healthcare settings, infection control measures such as sterilization and disinfection of equipment, and isolation precautions for patients with known gram-negative bacterial infections can help prevent the spread of these infections.

Overall, gram-negative bacterial infections are a significant public health concern, and proper diagnosis and treatment are essential to prevent complications and reduce the risk of transmission.

Bacteremia can occur when bacteria enter the bloodstream through various means, such as:

* Infected wounds or surgical sites
* Injecting drug use
* Skin infections
* Respiratory tract infections
* Urinary tract infections
* Endocarditis (infection of the heart valves)

The symptoms of bacteremia can vary depending on the type of bacteria and the severity of the infection. Some common symptoms include:

* Fever
* Chills
* Headache
* Muscle aches
* Weakness
* Confusion
* Shortness of breath

Bacteremia is diagnosed by blood cultures, which involve collecting blood samples and inserting them into a specialized container to grow the bacteria. Treatment typically involves antibiotics and supportive care, such as intravenous fluids and oxygen therapy. In severe cases, hospitalization may be necessary to monitor and treat the infection.

Prevention measures for bacteremia include:

* Practicing good hygiene, such as washing hands regularly
* Avoiding sharing personal items like toothbrushes or razors
* Properly cleaning and covering wounds
* Getting vaccinated against infections that can lead to bacteremia
* Following proper sterilization techniques during medical procedures

Overall, bacteremia is a serious condition that requires prompt medical attention to prevent complications and ensure effective treatment.

Some common types of lung diseases include:

1. Asthma: A chronic condition characterized by inflammation and narrowing of the airways, leading to wheezing, coughing, and shortness of breath.
2. Chronic Obstructive Pulmonary Disease (COPD): A progressive condition that causes chronic inflammation and damage to the airways and lungs, making it difficult to breathe.
3. Pneumonia: An infection of the lungs that can be caused by bacteria, viruses, or fungi, leading to fever, chills, coughing, and difficulty breathing.
4. Bronchiectasis: A condition where the airways are damaged and widened, leading to chronic infections and inflammation.
5. Pulmonary Fibrosis: A condition where the lungs become scarred and stiff, making it difficult to breathe.
6. Lung Cancer: A malignant tumor that develops in the lungs, often caused by smoking or exposure to carcinogens.
7. Cystic Fibrosis: A genetic disorder that affects the respiratory and digestive systems, leading to chronic infections and inflammation in the lungs.
8. Tuberculosis (TB): An infectious disease caused by Mycobacterium Tuberculosis, which primarily affects the lungs but can also affect other parts of the body.
9. Pulmonary Embolism: A blockage in one of the arteries in the lungs, often caused by a blood clot that has traveled from another part of the body.
10. Sarcoidosis: An inflammatory disease that affects various organs in the body, including the lungs, leading to the formation of granulomas and scarring.

These are just a few examples of conditions that can affect the lungs and respiratory system. It's important to note that many of these conditions can be treated with medication, therapy, or surgery, but early detection is key to successful treatment outcomes.

Bronchopneumonia is a serious condition that can lead to respiratory failure and other complications if left untreated. It is important for individuals with bronchopneumonia to seek medical attention promptly if they experience any worsening symptoms or signs of infection, such as increased fever or difficulty breathing.

Bronchopneumonia can be caused by a variety of factors, including bacterial and viral infections, and can affect individuals of all ages. It is most common in young children and the elderly, as well as those with pre-existing respiratory conditions such as asthma or chronic obstructive pulmonary disease (COPD).

Treatment for bronchopneumonia typically involves antibiotics to treat any bacterial infections, as well as supportive care to help manage symptoms and improve lung function. In severe cases, hospitalization may be necessary to provide more intensive treatment and monitoring.

In addition to antibiotics and supportive care, other treatments for bronchopneumonia may include:

* Oxygen therapy to help increase oxygen levels in the blood
* Pain management medications to relieve chest pain and fever
* Breathing exercises and pulmonary rehabilitation to improve lung function
* Rest and relaxation to help the body recover

Prevention is key in avoiding bronchopneumonia, and this can be achieved through:

* Good hand hygiene and respiratory etiquette
* Avoiding close contact with individuals who are sick
* Getting vaccinated against pneumococcal disease and the flu
* Practicing good hygiene during travel to avoid exposure to respiratory infections.

In conclusion, bronchopneumonia is a serious condition that can be caused by a variety of factors and can affect individuals of all ages. Treatment typically involves antibiotics and supportive care, and prevention strategies include good hygiene practices and vaccination. With proper treatment and care, individuals with bronchopneumonia can recover and lead active lives.

The hallmark symptoms of bronchiectasis are chronic cough, recurrent respiratory tract infections, and excessive mucus production. These symptoms can significantly impact quality of life, and if left untreated, the disease can progress to severe respiratory failure and other complications such as pulmonary hypertension.

Bronchiectasis is most commonly caused by recurrent lower respiratory tract infections, such as those caused by Pneumocystis jirovecii (formerly known as Pneumocystis carinii) and Haemophilus influenzae type b (Hib). Other risk factors for developing bronchiectasis include a history of childhood respiratory infections, exposure to tobacco smoke, and underlying conditions such as cystic fibrosis or primary immunodeficiency disorders.

Diagnosis of bronchiectasis typically involves a combination of clinical evaluation, radiologic imaging (such as high-resolution computed tomography, or HRCT), and pulmonary function tests. Treatment options for bronchiectasis include antibiotics to manage infections, bronchodilators to improve lung function, and airway clearance techniques such as chest physical therapy and pulmonary rehabilitation. In severe cases, lung transplantation may be considered.

Preventive measures for bronchiectasis include prompt treatment of respiratory infections, avoiding exposure to environmental irritants such as tobacco smoke, and managing underlying conditions that increase the risk of developing the disease. Early diagnosis and aggressive management of bronchiectasis can help slow disease progression, improve quality of life, and reduce the risk of complications such as respiratory failure and lung cancer.

The common types of RTIs include:

1. Common cold: A viral infection that affects the upper respiratory tract, causing symptoms such as runny nose, sneezing, coughing, and mild fever.
2. Influenza (flu): A viral infection that can affect both the upper and lower respiratory tract, causing symptoms such as fever, cough, sore throat, and body aches.
3. Bronchitis: An inflammation of the bronchial tubes, which can be caused by viruses or bacteria, resulting in symptoms such as coughing, wheezing, and shortness of breath.
4. Pneumonia: An infection of the lungs that can be caused by bacteria, viruses, or fungi, leading to symptoms such as fever, chills, coughing, and difficulty breathing.
5. Tonsillitis: An inflammation of the tonsils, which can be caused by bacteria or viruses, resulting in symptoms such as sore throat, difficulty swallowing, and bad breath.
6. Sinusitis: An inflammation of the sinuses, which can be caused by viruses, bacteria, or fungi, leading to symptoms such as headache, facial pain, and nasal congestion.
7. Laryngitis: An inflammation of the larynx (voice box), which can be caused by viruses or bacteria, resulting in symptoms such as hoarseness, loss of voice, and difficulty speaking.

RTIs can be diagnosed through physical examination, medical history, and diagnostic tests such as chest X-rays, blood tests, and nasal swab cultures. Treatment for RTIs depends on the underlying cause and may include antibiotics, antiviral medications, and supportive care to manage symptoms.

It's important to note that RTIs can be contagious and can spread through contact with an infected person or by touching contaminated surfaces. Therefore, it's essential to practice good hygiene, such as washing hands frequently, covering the mouth and nose when coughing or sneezing, and avoiding close contact with people who are sick.

Here are some key points to define sepsis:

1. Inflammatory response: Sepsis is characterized by an excessive and uncontrolled inflammatory response to an infection. This can lead to tissue damage and organ dysfunction.
2. Systemic symptoms: Patients with sepsis often have systemic symptoms such as fever, chills, rapid heart rate, and confusion. They may also experience nausea, vomiting, and diarrhea.
3. Organ dysfunction: Sepsis can cause dysfunction in multiple organs, including the lungs, kidneys, liver, and heart. This can lead to organ failure and death if not treated promptly.
4. Infection source: Sepsis is usually caused by a bacterial infection, but it can also be caused by fungal or viral infections. The infection can be localized or widespread, and it can affect different parts of the body.
5. Severe sepsis: Severe sepsis is a more severe form of sepsis that is characterized by severe organ dysfunction and a higher risk of death. Patients with severe sepsis may require intensive care unit (ICU) admission and mechanical ventilation.
6. Septic shock: Septic shock is a life-threatening condition that occurs when there is severe circulatory dysfunction due to sepsis. It is characterized by hypotension, vasopressor use, and organ failure.

Early recognition and treatment of sepsis are critical to preventing serious complications and improving outcomes. The Sepsis-3 definition is widely used in clinical practice to diagnose sepsis and severe sepsis.

Symptoms of otitis externa may include:

* Ear pain or tenderness
* Redness and swelling of the ear canal
* Discharge or pus in the ear canal
* Itching or burning sensation in the ear canal
* Fever or chills
* Difficulty hearing or feeling as if the ear is clogged

Otitis externa can be diagnosed by a healthcare professional through a physical examination of the ear canal and may also involve a pus sample or imaging tests such as X-rays or CT scans to rule out other conditions. Treatment options for otitis externa may include antibiotics, anti-inflammatory medications, or topical creams or drops to reduce pain and inflammation. In severe cases, surgery may be necessary to remove any infected tissue or debris from the ear canal.

Prevention of otitis externa includes avoiding exposure to moisture, using earplugs when swimming or showering, and keeping the ears clean and dry. If you suspect you have otitis externa, it is important to seek medical attention promptly to prevent complications such as mastoiditis or meningitis.

If left untreated, folliculitis can lead to more serious infections such as boils or abscesses, which may require surgical drainage. It is also possible for folliculitis to cause scarring and permanent hair loss if the inflammation damages the hair follicle.

While anyone can develop folliculitis, it is more common in people with oily skin or those who wear tight clothing or heavy makeup that can clog pores and irritate the skin. Additionally, certain medical conditions such as diabetes, HIV/AIDS, and cancer can increase the risk of developing folliculitis.

Folliculitis is usually diagnosed through a physical examination and may require a biopsy to rule out other skin conditions. Treatment options for folliculitis depend on the severity and cause of the condition, but may include antibiotics, topical creams, or oral medications. It is important to seek medical attention if symptoms persist or worsen over time, as early treatment can help prevent complications and improve outcomes.

Wikimedia Commons has media related to Pseudomonas aeruginosa. Type strain of Pseudomonas aeruginosa at BacDive - the Bacterial ... P. aeruginosa is the type species of the genus Pseudomonas. Identification of P. aeruginosa can be complicated by the fact ... "What Is a Pseudomonas Infection?". MedicineNet. Retrieved 8 December 2020. "Pseudomonas aeruginosa in Healthcare Settings". ... among the Pseudomonas Major Evolutionary Groups Reveals Species-Specific Adaptations for Pseudomonas aeruginosa and Pseudomonas ...
The Pseudomonas aeruginosa Hol Holin (Hol Holin) Family (TC# 1.E.20) is a group of transporters belonging to the Holin ... Portal: Biology As of this edit, this article uses content from "1.E.20 The Pseudomonas aeruginosa Hol Holin (Hol Holin) Family ... The hol gene (PRF9) product (117 aas) of Pseudomonas aeruginosa PAO1 exhibits a hydrophobicity profile similar to holins of P2 ... "1.E.20 The Pseudomonas aeruginosa Hol Holin (Hol Holin) Family". Transporter Classification Database. Retrieved 2016-03-20. ...
However, some bacteria in which cyclic di-GMP has been studied lack cyclic di-GMP-I riboswitches, e.g. Pseudomonas aeruginosa. ...
Thi Bach Nguyen H, Romero AD, Amman F, Sorger-Domenigg T, Tata M, Sonnleitner E, Bläsi U (Oct 2018). "Pseudomonas aeruginosa". ... E.g., in the opportunistic human pathogen Pseudomonas aeruginosa the sRNA ReaL translationally silences rpoS mRNA. RpoS ...
Rhamnolipids, which can be produced by some species of Pseudomonas, e.g., Pseudomonas aeruginosa. Sophorolipids are produced by ... Oliveira, F. J. S.; Vazquez, L.; de Campos, N. P.; de França, F. P., Production of rhamnolipids by a Pseudomonas alcaligenes ...
... (EC 3.4.24.26, Pseudomonas elastase, Pseudomonas aeruginosa neutral metalloproteinase) is an enzyme. This enzyme ... Nishino N, Powers JC (April 1980). "Pseudomonas aeruginosa elastase. Development of a new substrate, inhibitors, and an ... Bever RA, Iglewski BH (September 1988). "Molecular characterization and nucleotide sequence of the Pseudomonas aeruginosa ... "Pseudomonas aeruginosa elastase: affinity chromatography and some properties as a metallo-neutral proteinase". Agric. Biol. ...
and Pseudomonas aeruginosa. Dentists are at the top of the working groups who have a high risk of exposure to COVID-19. SARS- ...
and Pseudomonas aeruginosa. Exposure to higher doses of radiation is associated with systemic anaerobic infections due to gram ... including Pseudomonas aeruginosa and certain Enterobacteriaceae that generally are resistant to most third-generation ... and organisms that are acquired from the environment such as Pseudomonas spp. Organisms causing sepsis following exposure to ... Ciprofloxacin is effective against Gram-negative organisms (including Pseudomonas species) but has poor coverage for Gram- ...
CR Pseudomonas aeruginosa is commonly present in intensive-care units, and can lead to dangerous infections. In Thai hospitals ... "Pseudomonas aeruginosa - HAI". CDC. February 2021. Retrieved 13 April 2022. Guh Alice Y.; Bulens Sandra N.; Mu Yi; Jacob Jesse ... and Multidrug-Resistant Pseudomonas aeruginosa". Mayo Clinic Proceedings. 86 (3): 250-259. doi:10.4065/mcp.2010.0674. PMC ... aeruginosa predominantly but also found in K. pneumoniae and E. coli), and KPC (10 types of K. pneumoniae carbapenemase). At ...
O'Toole, G. A.; Kolter, R. (October 1998). "Flagellar and twitching motility are necessary for Pseudomonas aeruginosa biofilm ... Friedman, Lisa; Kolter, Roberto (2004). "Genes involved in matrix formation in Pseudomonas aeruginosa PA14 biofilms". Molecular ... O'Toole, GA; Flagellar, Kolter R. (1998). "Pseudomonas aeruginosa biofilm development". Mol Microbiol. 30 (2): 295-304. doi: ... of Pseudomonas aeruginosa". Journal of Bacteriology. 189 (14): 5383-5386. doi:10.1128/JB.00137-07. ISSN 0021-9193. PMC 1951888 ...
It can be caused by infection, particularly from Pseudomonas species, such as Pseudomonas aeruginosa, Clostridium species, ... Bodey, G. P.; Bolivar, R.; Fainstein, V.; Jadeja, L. (1983). "Infections Caused by Pseudomonas aeruginosa". Clinical Infectious ... and ecthyma gangrenosum in an immunocompromised host with pseudomonas septicemia". American Journal of Ophthalmology. 137 (1): ...
Walker GC, Nicholas DJ (1961). "Nitrite reductase from Pseudomonas aeruginosa". Biochim. Biophys. Acta. 49 (2): 350-360. doi: ... Singh J (1974). "Cytochrome oxidase from Pseudomonas aeruginosa. III. Reduction of hydroxylamine". Biochim. Biophys. Acta. 333 ... "In vivo studies disprove an obligatory role of azurin in denitrification in Pseudomonas aeruginosa and show that azu expression ...
... was shown to be ineffective in vitro against Enterobacter spp., Pseudomonas aeruginosa, and Xanthomonas maltophilia ...
Erwinia herbicola and Pseudomonas aeruginosa are known to have homologues for cyclohexadienyl dehydratase. Of the plants with ... Zhao GS, Xia TH, Fischer RS, Jensen RA (February 1992). "Cyclohexadienyl dehydratase from Pseudomonas aeruginosa. Molecular ... "The crystal structure of cyclohexadienyl dehydratase precursor from Pseudomonas aeruginosa PA01". doi:10.2210/pdb3kbr/pdb. ...
... exotoxin A of Pseudomonas aeruginosa; pertussis toxin of B. pertussis; C3 toxin of C. botulinum; and diphtheria toxin of ...
"Hydroxylamine reductase from Pseudomonas aeruginosa". Biochim. Biophys. Acta. 49 (2): 361-368. doi:10.1016/0006-3002(61)90135-4 ...
Pseudomonas Aeruginosa species of bacteria are the most common causes of Green Nail Syndrome. Nail scrapings have identified ... Green nail syndrome, is a paronychial infection caused due to Pseudomonas aeruginosa that can develop in individuals whose ... "Pseudomonas aeruginosa Infections: Clinical Presentation". eMedicine. Retrieved 1 February 2014. James, William; Berger, ... It is unsure whether these are causative organisms or simply coinfections alongside Pseudomonas Aeruginosa. Diagnosis can ...
Fewson CA, Nicholas DJ (May 1961). "Nitrate reductase from Pseudomonas aeruginosa". Biochimica et Biophysica Acta. 49 (2): 335- ...
... may be (1) due to a Pseudomonas aeruginosa infection causing a green nail syndrome or (2) the result of copper in ... ISBN 0-7216-2921-0. Balcht, Aldona; Smith, Raymond (1994). Pseudomonas Aeruginosa: Infections and Treatment. Informa Health ... 791 Pseudomonas aeruginosa is a common bacterium that can cause disease in animals, including humans. It is found in soil, ...
Ramakrishnan T; Campbell JJR (1955). "Gluconic dehydrogenase of Pseudomonas aeruginosa". Biochim. Biophys. Acta. 17 (1): 122- ...
Michel-Briand Y, Baysse C (May 2002). "The pyocins of Pseudomonas aeruginosa". Biochimie. 84 (5-6): 499-510. doi:10.1016/S0300- ... Furthermore, bacteriocins active against E. coli, Salmonella and Pseudomonas aeruginosa have been produced in planta with the ... Michel-Briand Y, Baysse C (2002). "The pyocins of Pseudomonas aeruginosa". Biochimie. 84 (5-6): 499-510. doi:10.1016/s0300-9084 ... Most well studied are the tailocins of Pseudomonas aeruginosa. They can be further subdivided into R-type and F-type pyocins. ...
... and Pseudomonas aeruginosa". Frontiers in Immunology. 6: 595. doi:10.3389/fimmu.2015.00595. PMC 4655328. PMID 26635809. ... The enzymes involved in Lipid A synthesis are conserved among Pseudomonas aeruginosa, Escherichia coli, Bordetella ... "Lipopolysaccharide biosynthesis in Pseudomonas aeruginosa". Innate Immunity. 15 (5): 261-312. doi:10.1177/1753425909106436. ...
Guan R, Ho MC, Almo SC, Schramm VL (February 2011). "Methylthioinosine phosphorylase from Pseudomonas aeruginosa. Structure and ... methylthioadenosine in Pseudomonas aeruginosa involves deamination to S-methyl-5'-thioinosine (EC 3.5.4.31, S-methyl-5'- ...
"Tolerance and Resistance of Pseudomonas aeruginosa Biofilms to Antimicrobial Agents-How P. aeruginosa Can Escape Antibiotics". ... Secreted by Pseudomonas aeruginosa, this compound induces cyclo heteromorphic cells in several species of bacteria and the ... Moreover, Pseudomonas aeruginosa biofilms can impede the slithering motility of C. elegans, termed as 'quagmire phenotype', ... For instance, the biofilm form of Pseudomonas aeruginosa has no greater resistance to antimicrobials than do stationary-phase ...
IPL is a PchB enzyme originating from the pchB gene in Pseudomonas aeruginosa. Isochorismate lyase, or PchB, is part of the ... Olucha J, Ouellette AN, Luo Q, Lamb AL (August 2011). "pH Dependence of catalysis by Pseudomonas aeruginosa isochorismate- ... "BRENDA - Information on EC 4.2.99.21 - isochorismate lyase and Organism(s) Pseudomonas aeruginosa". www.brenda-enzymes.info. ... Derived from the pchB gene of Pseudomonas aeruginosa, other names for isochorismate lyase include: salicylate biosynthesis ...
She is known for her research on bacterial infections caused by Pseudomonas aeruginosa. Kalai Mathee was born into a working- ... Since 1993, the major focus of Mathee's research has been the pathobiology of Pseudomonas aeruginosa chronic infections with ... Mathee has examined the role of quorum sensing molecules in Pseudomonas aeruginosa infections, and demonstrated that alginate ... Her work has used comparative genomics and transcriptomics to define variability across strains of Pseudomonas aeruginosa. A ...
Pseudomonas aeruginosa Pseudomonas pyocyanea Salmonella spp. Selenomonas sputigena Shigella sonnei Staphylococcus aerogenes ... Rada B, Leto TL (2009). "Redox warfare between airway epithelial cells and Pseudomonas: Dual oxidase versus pyocyanin". Immunol ... Rada B, Leto TL (2009). "Redox warfare between airway epithelial cells and Pseudomonas: Dual oxidase versus pyocyanin". Immunol ...
Comolli, J. C.; Hauser, A. R.; Waite, L.; Whitchurch, C. B.; Mattick, J. S.; Engel, J. N. (July 1999). "Pseudomonas aeruginosa ... It has been observed in many bacterial species, but is most well studied in Pseudomonas aeruginosa, Neisseria gonorrhoeae and ... Burrows, Lori L. (2012). "Pseudomonas aeruginosa twitching motility: type IV pili in action". Annual Review of Microbiology. 66 ... Parsek, Matthew R.; Tolker-Nielsen, Tim (December 2008). "Pattern formation in Pseudomonas aeruginosa biofilms". Current ...
Pseudomonas aeruginosa, Salmonella enterica, E.coli. Firmacutes [sic] (gram positive, subsequently corrected to Firmicutes) ... The class Schizomycetes was then emended by Walter Migula (along with the coinage of the genus Pseudomonas in 1894) and others ...
In case of people having a high risk of being infected with multiple drug resistant organisms such as Pseudomonas aeruginosa, ... Other commonly implicated bacteria include Streptococcus pyogenes, Escherichia coli, Pseudomonas aeruginosa, and Klebsiella ... The bacteria Streptococcus pneumoniae, Escherichia coli, Proteus spp., Pseudomonas aeruginosa, Staphylococcus aureus, ...
"Structural and functional characterisation of the entry point to pyocyanin biosynthesis in Pseudomonas aeruginosa defines a new ...
... while more severe cases require cephalosporins with activity against Pseudomonas aeruginosa (e.g. cefepime), or carbapenems ( ...
RK2 was first isolated in connection with an outbreak of antibiotic-resistant Pseudomonas aeruginosa and Klebsiella aerogenes ... "Molecular Characterization of the R Factors Implicated in the Carbenicillin Resistance of a Sequence of Pseudomonas aeruginosa ... The copy number of RK2 is about 4-7 per cell in E. coli and 3 in P. aeruginosa. Several minimal derivatives of RK2 have been ...
"Structural and binding studies of peptidyl-tRNA hydrolase from Pseudomonas aeruginosa provide a platform for the structure- ...
Among these are Pseudomonas aeruginosa, which has a grape-like scent; Staphylococcus aureus, which is said to smell like old ... Pseudomonas aeruginosa produces the pigments pyocyanin and pyoverdin, which give the colonies a greenish sheen.: 473 : 154 Some ...
Voellmy R, Leisinger T (1975). "Dual role for N-2-acetylornithine 5-aminotransferase from Pseudomonas aeruginosa in arginine ...
... and the bacterium Pseudomonas aeruginosa. Buddie AG, Bridge PD, Kelley J, Ryan MJ (2010). "Candida keroseneae sp. nov., a novel ...
... along with bacteria Pseudomonas Aeruginosa, and fungi such as yeasts and moulds like Yarrowia tropicalis. In essence "polishing ...
Streptococcus pneumoniae Staphylococcus aureus Haemophilus influenzae Pseudomonas aeruginosa Klebsiella: often seen in ...
Pseudomonas aeruginosa and Staphylococcus aureus. It is also used against nausea and vomiting, parasitic infections, both ...
Phenolics have high antimicrobial activity against bacteria such as Staphylococcus epidermidis and Pseudomonas aeruginosa.[ ...
"Characterization of 3-guanidinopropionate amidinohydrolase from Pseudomonas aeruginosa and a comparative study with 4- ... guanidinobutyrate amidinohydrolase from another Pseudomonas". Agric. Biol. Chem. 46 (5): 1361-1363. doi:10.1271/bbb1961.46.1361 ...
"Identification of 17 Pseudomonas aeruginosa sRNAs and prediction of sRNA-encoding genes in 10 diverse pathogens using the ... Pseudomonas sRNA P1 Pseudomonas sRNA P9 Pseudomonas sRNA P11 Pseudomonas sRNA P15 Pseudomonas sRNA P24 Pseudomonas sRNA P26 ... negatively regulates rpoS expression in Pseudomonas aeruginosa". Microbiology. 164 (4): 716-724. doi:10.1099/mic.0.000632. ISSN ... Page for Pseudomonas sRNA P16 at Rfam v t e (Non-coding RNA, All stub articles, Molecular and cellular biology stubs). ...
Pseudomonas aeruginosa Salmonella enteritidis These and many other damaging contaminants can infiltrate critical areas in a ... and Pseudomonas aeruginosa. The EPA has determined that when cleaned regularly, these copper alloy surfaces: Continuously ...
... identified as an active LasI quorum-sensing signal molecule important for the plant growth promotion by Pseudomonas aeruginosa ...
... including Pseudomonas aeruginosa, and Gram-positive bacteria. Bacteroides fragilis, enterococci, Pseudomonas spp. and ...
... due to the risk of contamination with Pseudomonas aeruginosa bacteria. In January 2013, Health Canada advised of Arbonne's ...
"Extracellular DNA chelates cations and induces antibiotic resistance in Pseudomonas aeruginosa biofilms". PLOS Pathogens. 4 (11 ...
... stream infection Staphylococcus aureus Methicillin resistant Staphylococcus aureus Candida albicans Pseudomonas aeruginosa ...
Pseudomonas aeruginosa is a bacterium that can cause respiratory infections. It is frequently associated with cystic fibrosis ... Pang Z, Raudonis R, Glick BR, Lin TJ, Cheng Z (January-February 2019). "Antibiotic resistance in Pseudomonas aeruginosa: ...
Pseudomonas aeruginosa) bacteria. The mechanism of bacterial killing by PGLYRP3 is based on induction of lethal envelope stress ...
"Attenuation of Pseudomonas aeruginosa virulence by quorum sensing inhibitors". The EMBO Journal. 22 (15): 3803-3815. doi: ... "Regulation of the alginate biosynthesis gene algC in Pseudomonas aeruginosa during biofilm development in continuous culture". ... and low metabolic activity to tolerance of Pseudomonas aeruginosa biofilms to ciprofloxacin and tobramycin". Antimicrobial ... "A genetic basis for Pseudomonas aeruginosa biofilm antibiotic resistance". Nature. 426 (6964): 306-310. Bibcode:2003Natur.426.. ...
Kinetic studies of the reaction mechanism of carnitine dehydrogenase of Pseudomonas aeruginosa]. Eur. J. Biochem. (in German). ... Purification and properties of carnitine dehydrogenase from Pseudomonas aeruginosa]. Eur. J. Biochem. (in German). 6 (2): 196- ... "Kinetische Untersuchungen zum Reaktionsmechanismus der Carnitindehydrogenase aus Pseudomonas aeruginosa" [ ... "Reinigung und Eigenschaften der Carnitindehydrogenase aus Pseudomonas aeruginosa" [ ...
"Ligand-induced conformational changes of betaine aldehyde dehydrogenase from Pseudomonas aeruginosa and Amaranthus ...
Pseudomonas aeruginosa, and Escherichia coli. Chloroform extracts from dried leaves of P. pellucida have been shown to exhibit ...
It is also active against the fungus Candida albicans, but has no activity against Pseudomonas aeruginosa. Hepcidin synthesis ...
0.03 μg/mL - 2 μg/mL Pseudomonas aeruginosa 4 μg/mL - 6.25 μg/mL An interesting alternative synthesis of azlocillin involves ... It demonstrates antibacterial activity against a broad spectrum of bacteria, including Pseudomonas aeruginosa and, in contrast ...
... enzymes in the Wbp pathway responsible for O-antigen assembly in Pseudomonas aeruginosa PAO1". Biochemistry. 48 (23): 5446-55. ... 3-dideoxy-D-mannuronic acid in Pseudomonas aeruginosa". The Journal of Biological Chemistry. 284 (18): 11854-62. doi:10.1074/ ...
"Effect of Myrtol standardized on mucus hypersecretion and clearance of Pseudomonas aeruginosa in a rat model of chronic ... after bacterial infection with Pseudomonas aeruginosa. Anti-inflammatory actions: Inflammations of the airways as in acute and ...
Pseudomonas aeruginosa is a type of germ that can cause infections in humans, mostly in hospital patients. It can cause ... Pseudomonas aeruginosa lives in the environment and can be spread to people in healthcare settings when they are exposed to ... CDC tracks Pseudomonas aeruginosa and the infections this germ can cause, including antibiotic-resistant infections. ... Pseudomonas aeruginosa infections are generally treated with antibiotics. Unfortunately, in people exposed to healthcare ...
Pseudomonas is a gram-negative rod that belongs to the family Pseudomonadaceae. More than half of all clinical isolates produce ... encoded search term (Pseudomonas aeruginosa Infections) and Pseudomonas aeruginosa Infections What to Read Next on Medscape ... Pseudomonas aeruginosa Infections. Updated: Mar 03, 2023 * Author: Shahab Qureshi, MD, FACP; Chief Editor: Michael Stuart ... Infections with Pseudomonas aeruginosa in Charcot arthropathy of the foot. Foot Ankle Int. 2013 Feb. 34(2):234-7. [QxMD MEDLINE ...
Pseudomonas Ortholog Database. View orthologs at Pseudomonas Ortholog Database Pseudomonas Ortholog Group. POG000448 (340 ... Enhanced annotations and features for comparing thousands of Pseudomonas genomes in the Pseudomonas genome database. ... If you have used this database, please ensure that you acknowledge this most recent Pseudomonas Genome Database publication ...
Outbreak of Extensively Drug-resistant Pseudomonas aeruginosa Associated with Artificial Tears. ... producing carbapenem-resistant Pseudomonas aeruginosa (VIM-GES-CRPA) in 12 states. Most patients reported using artificial ... Clinical laboratories that identify any carbapenem-resistant P. aeruginosa from an ocular specimen or VIM-CRPA from any ... Clinical laboratories that identify P. aeruginosa resistant to imipenem or meropenem are encouraged to perform carbapenem ...
Pseudomonas aeruginosa, Staphylococcus aureus, and Fluoroquinolone Use On This Page Methods Measurement of Hospital ... Pseudomonas aeruginosa, Staphylococcus aureus, and Fluoroquinolone Use. Emerging Infectious Diseases. 2005;11(8):1197-1210. doi ... A) Changes in fluoroquinolone use (x axis) and resistance in Pseudomonas aeruginosa (y axis) for 9 hospitals with complete data ... A) Changes in fluoroquinolone use (x axis) and resistance in Pseudomonas aeruginosa (y axis) for 9 hospitals with complete data ...
Gram-negative bacteria including P. aeruginosa employ N-acyl homoserine lactones (AHLs) as chemical signals to regulate the ... The quorum sensing inhibition (QSI) activity of the synthesized compounds was determined against a P. aeruginosa MH602 reporter ... Computational docking studies performed using the LasR receptor protein of P. aeruginosa suggested the importance of hydrogen ... particularly hospital-acquired infections caused by Pseudomonas aeruginosa, have become a global threat with a high mortality ...
Minimum bactericidal concentration against Pseudomonas aeruginosa; value ranges from 2-4 ug cm-3. ...
Persistent Pseudomonas Aeruginosa Infection in a child with Cystic Fibrosis - How to manage? ... Her sputum cultures continued to grow Pseudomonas aeruginosa on and off. In December 2013, the P. aeruginosa was resistant to ... Persistent Pseudomonas Aeruginosa Infection in a child with Cystic Fibrosis - How to manage?. Full Text ... Persistent Pseudomonas Aeruginosa Infection in a child with Cystic Fibrosis - How to manage?. 09/06/2018 09/06/2018 Lavina ...
Potency of Two Ear Cleansers In vitro Against Staphylococcus Intermedius, Pseudomonas Aeruginosa and Malassezia Pachydermatis ... Pseudomonas aeruginosa and Malassezia pachydermatis. The relative rates of microbicidal activity of the two ear cleansers were ... aeruginosa whilst Otoclean has delayed activity against some isolates when diluted 5-fold. This could be important since ... The potent activity of Epi-Otic against Pseudomonas is also of special interest in view of the increasing resistance shown by ...
Outbreak of Extensively Drug-resistant Pseudomonas aeruginosa Associated with Artificial Tears. ... producing carbapenem-resistant Pseudomonas aeruginosa (VIM-GES-CRPA) in 12 states. Most patients reported using artificial ... Clinical laboratories that identify any carbapenem-resistant P. aeruginosa from an ocular specimen or VIM-CRPA from any ... Clinical laboratories that identify P. aeruginosa resistant to imipenem or meropenem are encouraged to perform carbapenem ...
Pseudomonas aeruginosa infections and biofilms have been implicated in recalcitrant CRS. One of the mechanisms of action for ... Pseudomonas aeruginosa infections and biofilms have been implicated in recalcitrant CRS. One of the mechanisms of action for ... Association between mucosal barrier disruption by Pseudomonas aeruginosa exoproteins and asthma in patients with chronic ... However, the role of biofilm and planktonic forms of P. aeruginosa in this process is not known. The aim is to determine the ...
Acinetobacter baumannii и Pseudomonas aeruginosa в медицинских учреждениях. ... Acinetobacter baumannii и Pseudomonas aeruginosa в медицинских учреждениях. Всемирная организация здравоохранения. Европейское ...
The density of Pseudomonas aeruginosa in sputum decreased slightly: mean (SD) -1.0 (2.70) ... Long term safety of inhaled tobramycin to treat Pseudomonas Aeruginosa infection in people With CF ... At least 6 years of age, chronic Pseudomonas aeruginosa lung infection, completed feeder study. ... When used as a treatment for long term (chronic) Pseudomonas lung infection, tobramycin inhalation powder used twice a day, on ...
Pseudomonas: global bacteria. Trends in Microbiology, 2000, 8:55-57.. *Kimata N et al. Pseudomonas aeruginosa isolated from ... ABSTRACT Pseudomonas aeruginosa is an important agent of opportunistic infection in aquatic environments. Our aim was to ... Pseudomonas aeruginosa belongs to a vast genus of obligate aerobic, non-fermenting, saprophytic, Gram-negative bacilli ... Incidence of Pseudomonas aeruginosa in recreational and hydrotherapy pools. Communicable Disease and Public Health, 2002, 5:23- ...
Pseudomonas aeruginosa (PA) is an opportunistic pathogen that can cause infections in patients with compromised immunity ... Muntaka, Sirina (2017) The interplay between Pseudomonas aeruginosa and human macrophages and neutrophils. PhD thesis, ...
Previous work with Pseudomonas aeruginosa showed that catalase activity in biofilms was significantly reduced relative to that ... Factors affecting catalase expression in pseudomonas aeruginosa biofilms and planktonic cells (PDF) (327.6Kb) ... "Factors Affecting Catalase Expression in Pseudomonas aeruginosa Biofilms and Planktonic Cells,"" Appl. Environ. Microbiol. 67(3 ...
We have investigated the genotoxic potential of Pseudomonas aeruginosa, an opportunistic pathogen causing devastating ... Together, these data show for the first time that infection by P. aeruginosa activates the DNA double-strand break repair ... Our data revealed that infection of immune or epithelial cells by P. aeruginosa triggered DNA strand breaks and phosphorylation ... This novel information sheds new light on the consequences of P. aeruginosa infection in mammalian cells. As pathogenic ...
Pseudomonas aeruginosa has become a model organism for the study of biofilms due to its metabolic versatility and variability ... P. aeruginosa is also a human pathogen that causes infection in burn patients, and is the predominant cause of lung infections ... Pseudomonas aeruginosa has become a model organism for the study of biofilms due to its metabolic versatility and variability ... P. aeruginosa is also a human pathogen that causes infection in burn patients, and is the predominant cause of lung infections ...
Pseudomonas aeruginosa is the gram negative rod shaped bacteria is found in all natural and man made environments. the organism ... Pseudomonas aeruginosa is a species present in this group sharing the with other twelve members. Pseudomonas aeruginosa is a ... Pseudomonas aeruginosa Biofilms. The communities of microbial bacteria(Pseudomonas aeruginosa) forms a definite structures with ... Pseudomonas Aeruginosa Gene Expression. ✅ Paper Type: Free Essay. ✅ Subject: Biology. ✅ Wordcount: 5478 words. ✅ Published: 7th ...
... aeruginosa, Pseudomonas polycolor, Pseudomonas pyocyanea, Pseudomonas sp. RV3, RH 815, VKM B-588, bacterium ASFP-37, bacterium ... Pseudomonas aeruginosa. NCBI taxonomy Id: 287. Other names: ATCC 10145, ATCC 10145-U, Bacillus aeruginosus, Bacillus pyocyaneus ... Bacterium aeruginosum, Bacterium pyocyaneum, CCEB 481, CCUG 28447, CCUG 29297, CCUG 551, CFBP 2466, CIP 100720, DSM 50071, IBCS ...
Pseudomonas aeruginosa; RNA Bacteriano; Animais; Humanos; Oxigênio/metabolismo; Pseudomonas aeruginosa/genética; Pseudomonas ... A Pseudomonas aeruginosa small RNA regulates chronic and acute infection. A Pseudomonas aeruginosa small RNA regulates chronic ... Pseudomonas aeruginosa / Infecções por Pseudomonas / RNA Bacteriano / Doença Aguda / Doença Crônica / Genes Bacterianos Limite: ... Pseudomonas aeruginosa / Infecções por Pseudomonas / RNA Bacteriano / Doença Aguda / Doença Crônica / Genes Bacterianos Limite: ...
Novel genetic determinants of low-level aminoglycoside resistance in Pseudomonas aeruginosa. Antimicrob. Agents Chemother. 52, ... Carbon sources tune antibiotic susceptibility in Pseudomonas aeruginosa via tricarboxylic acid cycle control. Cell Chem. Biol. ... Virulence Characteristics and an Action Mode of Antibiotic Resistance in Multidrug-Resistant Pseudomonas aeruginosa. 24 January ... Integrative analysis of fitness and metabolic effects of plasmids in Pseudomonas aeruginosa PAO1. 10 August 2018 ...
2022 Pseudomonas aeruginosa is one of the most common nosocomial infections worldwide, and it frequently caus... ... Pseudomonas aeruginosa is one of the most common nosocomial infections worldwide, and it frequently causes ventilator- ... CLEC5A is critical in Pseudomonas aeruginosa-induced NET formation and acute lung injury ... aeruginosa-induced NET formation and lung inflammation. P. aeruginosa activates CLEC5A to induce caspase-1-dependent NET ...
Return to Article Details Occurrence of blaKPC gene in clinical isolates of Pseudomonas aeruginosa from Brazil Download ...
4-Hidroksibenzoik Asitin Pseudomonas Aeruginosa Biyofilmi Üzerine Etkisinin ...
Pseudomonas aeruginosa is an important Gram-negative pathogen with intrinsic resistance to many clinically used antibiotics. It ... Pseudomonas aeruginosa, Membrane lipids, Bacteriophages -- Therapeutic use. Journal or Publication Title:. Environmental ... WRAP-membrane-lipid-renovation-Pseudomonas-aeruginosa‐implications-phage-therapy-2022.pdf - Accepted Version Embargoed item. ... 2022) Membrane lipid renovation in Pseudomonas aeruginosa ‐ implications for phage therapy? Environmental Microbiology, 24 (10 ...
Pseudomonas aeruginosa is a Gram-negative opportunistic pathogen which is a serious source of various hospital acquired ... Pseudomonas aeruginosa is a Gram-negative opportunistic pathogen which is a serious source of various hospital acquired ... Effect of Lactobacillus fermentum filtrate on Pseudomonas aeruginosa adhesion at biotic and abiotic surfaces. ... aeruginosa adhesion. Forty-five isolates of P. aeruginosa were obtained from clinical samples, the isolation frequency was ...
Return to Article Details The character of PA3235 virulence factors of Pseudomonas aeruginosa PAO1 - a preliminary study ...
  • Pseudomonas aeruginosa (PA) is an opportunistic pathogen that can cause infections in patients with compromised immunity including patients with neutropenia, HIV infection, burns, cancer, organ transplant surgery or in intensive care as well as Cystic Fibrosis (CF) patients. (nottingham.ac.uk)
  • ABSTRACT Pseudomonas aeruginosa is an important agent of opportunistic infection in aquatic environments. (who.int)
  • P. aeruginosa is an important agent of opportunistic infection in patients, particularly in those with respiratory complications and burns. (who.int)
  • The opportunistic pathogen Pseudomonas aeruginosa activates the DNA double-strand break signaling and repair pathway in infected cells. (inserm.fr)
  • We have investigated the genotoxic potential of Pseudomonas aeruginosa, an opportunistic pathogen causing devastating nosocomial infections in cystic fibrosis or immunocompromised patients. (inserm.fr)
  • P. aeruginosa is an opportunistic pathogen. (nih.gov)
  • And under normal circumstances, we don't get infections with opportunistic pathogens," said Fleiszig, who also studies the eye's defense mechanisms along with factors that enable P. aeruginosa to evade them. (nih.gov)
  • Here, by directly examining bacterial gene expression in human -derived samples, we discover a gene that orchestrates the transition between chronic and acute infection in the opportunistic pathogen Pseudomonas aeruginosa . (bvsalud.org)
  • Pseudomonas aeruginosa is a Gram-negative opportunistic pathogen which is a serious source of various hospital acquired diseases. (sysrevpharm.org)
  • P. aeruginosa is an opportunistic pathogen with well-documented biofilm phenotypes that are distinct from its planktonic phenotypes. (nih.gov)
  • Pseudomonas aeruginosa is an opportunistic pathogen often causing nosocomial infections that are resilient to treatment due to an extensive repertoire of intrinsic and acquired resistance mechanisms. (who.int)
  • Of the many different types of Pseudomonas , the one that most often causes infections in humans is called Pseudomonas aeruginosa , which can cause infections in the blood, lungs (pneumonia), or other parts of the body after surgery. (cdc.gov)
  • In 2017, multidrug-resistant Pseudomonas aeruginosa caused an estimated 32,600 infections among hospitalized patients and 2,700 estimated deaths in the United States [ Source: 2019 AR Threats Report ]. (cdc.gov)
  • Pseudomonas aeruginosa infections are generally treated with antibiotics. (cdc.gov)
  • Unfortunately, in people exposed to healthcare settings like hospitals or nursing homes, Pseudomonas aeruginosa infections are becoming more difficult to treat because of increasing antibiotic resistance. (cdc.gov)
  • CDC tracks Pseudomonas aeruginosa and the infections this germ can cause, including antibiotic-resistant infections. (cdc.gov)
  • Learn more about how CDC's Antibiotic Resistance Laboratory Network detects highly resistant Pseudomonas aeruginosa infections. (cdc.gov)
  • Bacterial infections, particularly hospital-acquired infections caused by Pseudomonas aeruginosa , have become a global threat with a high mortality rate. (mdpi.com)
  • The common presentations are meconium ileum in neonates, recurrent lower respiratory tract infections (Pseudomonas spp pneumonia, bronchiectasis), steatorrhoea, azoospermia, and in late stages hepatobiliary and endocrine pancreatic dysfunctions. (pediatriconcall.com)
  • Pseudomonas aeruginosa infections and biofilms have been implicated in recalcitrant CRS. (physiciansweekly.com)
  • The carbohydrate-binding protein LecA (PA-IL) from Pseudomonas aeruginosa plays an important role in the formation of biofilms in chronic infections. (fu-berlin.de)
  • P. aeruginosa is also a human pathogen that causes infection in burn patients, and is the predominant cause of lung infections and mortality in patients with cystic fibrosis (CF) [14,15]. (edu.au)
  • That's the story behind this image showing an intricate colony of millions of the single-celled bacterium Pseudomonas aeruginosa , a common culprit in the more than 700,000 hospital-acquired infections estimated to occur annually in the United States. (nih.gov)
  • Questions remain about artificial tears linked to an outbreak of Pseudomonas aeruginosa infections involving 68 people in 16 states, including 8 cases of vision loss, as well as lung and urinary tract infections, and one death. (nih.gov)
  • In studies funded by the NEI, Fleiszig uses P. aeruginosa as a model pathogenic organism to better understand the pathogenesis of bacterial eye infections. (nih.gov)
  • The expression level of this gene , here named sicX, is the highest of the P. aeruginosa genes expressed in human chronic wound and cystic fibrosis infections , but it is expressed at extremely low levels during standard laboratory growth . (bvsalud.org)
  • P. aeruginosa bacteria can cause mild illness in healthy people, such as ear infections and skin rashes after exposure to inadequately cleaned hot tubs or pools. (nih.gov)
  • However, serious P. aeruginosa -associated bloodstream infections and pneumonia can occur in hospitalized patients with weakened immune systems, including people who have wounds from surgery or are using breathing machines or catheters. (nih.gov)
  • Pseudomonas aeruginosa is one of the most common nosocomial infections worldwide, and it frequently causes ventilator-associated acute pneumonia in immunocompromised patients. (sinica.edu.tw)
  • Consideration of such effects needs to be urgently prioritised in order to develop the most effective phage therapy strategies for P. aeruginosa infections. (warwick.ac.uk)
  • Pseudomonas aeruginosa has been implicated in several nosocomial infections , where it has caused grave complications in immunocompromised patients . (bvsalud.org)
  • For more information, please go to Enterobacter Infections , Urinary Tract Infection (UTI) and Cystitis (Bladder Infection) in Females , Urinary Tract Infection in Males , Pseudomonas aeruginosa Infections , and Acinetobacter . (medscape.com)
  • Epi-Otic killed all 5 of the Pseudomonas isolates within 1 minute, both undiluted and at 1/5 dilution. (vin.com)
  • Exoproteins from 40 P. aeruginosa isolates were collected in planktonic and biofilm form and applied to air-liquid interface (ALI) cultures of primary human nasal epithelial cells (HNECs). (physiciansweekly.com)
  • Exoproteins from planktonic P. aeruginosa clinical isolates from asthmatic CRS patients have detrimental effects on the mucosal barrier and induce IL-6 production potentially contributing to the mucosal inflammation in CRS patients. (physiciansweekly.com)
  • Compared with other studies, the prevalence of P. aeruginosa in swimming pools was relatively low, while the antibiotic resistance pattern of these community isolates was not high. (who.int)
  • In this work, we apply genomic sequencing to 9 serially-collected P. aeruginosa isolates cultured during the course of an acute systemic infection in a single patient in which both a hypermutator phenotype and ceftazidime-avibactam (CZA) resistance rapidly emerged in vivo. (nih.gov)
  • We sequenced the whole genomes of 176 P. aeruginosa isolates collected in 2013-2014 by the Antimicrobial Resistance Surveillance Program. (who.int)
  • Pseudomonas aeruginosa isolates from this sample site showed the highest (100%) resistance to cephalosporins ( cefuroxime ) and nitrofurantoin . (bvsalud.org)
  • Pseudomonas aeruginosa has become an important cause of gram-negative infection, especially in patients with compromised host defense mechanisms. (medscape.com)
  • Desai L, Shah I. Persistent Pseudomonas Aeruginosa Infection in a child with Cystic Fibrosis - How to manage? (pediatriconcall.com)
  • When used as a treatment for long term (chronic) Pseudomonas lung infection, tobramycin inhalation powder used twice a day, on a month on-month off basis over 1 year, continues to appear effective and safe. (ecfs.eu)
  • Previous studies have shown it to have similar effectiveness to nebulised tobramycin solution for inhalation for people with chronic Pseudomonas lung infection. (ecfs.eu)
  • Our data revealed that infection of immune or epithelial cells by P. aeruginosa triggered DNA strand breaks and phosphorylation of histone H2AX (γH2AX), a marker of DNA double-strand breaks. (inserm.fr)
  • Together, these data show for the first time that infection by P. aeruginosa activates the DNA double-strand break repair machinery of the host cells. (inserm.fr)
  • This novel information sheds new light on the consequences of P. aeruginosa infection in mammalian cells. (inserm.fr)
  • However, the role of P. aeruginosa hypermution in the acute systemic infection remains unclear. (nih.gov)
  • 1] Mucin glycans attenuate the virulence of Pseudomonas aeruginosa in infection . (nih.gov)
  • While infection with the specific, highly resistant bacterial strain at the heart of the outbreak is rare, P. aeruginosa as a bacterial species is everywhere. (nih.gov)
  • A Pseudomonas aeruginosa small RNA regulates chronic and acute infection. (bvsalud.org)
  • Deletion of sicX causes P. aeruginosa to switch from a chronic to an acute lifestyle in multiple mammalian models of infection . (bvsalud.org)
  • P. aeruginosa undergoes changes in membrane lipids when it encounters phosphorus stress, an environmental perturbation that is likely to occur during infection. (warwick.ac.uk)
  • To investigate the efficacy and safety of 4 antipseudomonal treatments in children with cystic fibrosis with recently acquired Pseudomonas aeruginosa infection. (nih.gov)
  • The primary cause of death in individuals with CF is progressive obstructive pulmonary disease associated with chronic Pseudomonas aeruginosa (PA) infection. (nih.gov)
  • Previous work with Pseudomonas aeruginosa showed that catalase activity in biofilms was significantly reduced relative to that in planktonic cells. (montana.edu)
  • Pseudomonas aeruginosa has become a model organism for the study of biofilms due to its metabolic versatility and variability in its response to environmental signals, which promotes successful colonization of different habitats and growth under varying environmental conditions [12,13]. (edu.au)
  • 2] Mucins trigger dispersal of Pseudomonas aeruginosa biofilms . (nih.gov)
  • The functioning of the EPS matrix in holding cells of Pseudomonas aeruginosa together and forming the mature biofilms. (ukessays.com)
  • The exopolysaccharide genes such as pilB, pslA, lecA, ureB and alginate genes are responsible for the formation of pseudomonas biofilms. (ukessays.com)
  • The microcarriers made up of dextrons in the range of 60-90µm in size are used as a surface for Pseudomonas aeruginosa to form biofilms. (ukessays.com)
  • Reverse diauxie has been described in planktonic cultures, but it has not been documented explicitly in P. aeruginosa biofilms. (nih.gov)
  • Label-free proteomics identified dozens of proteins associated with biofilm formation including 16 that have not been previously reported, highlighting both the advantages of the methodology utilized here and the complexity of the proteomic adaptation for P. aeruginosa biofilms. (nih.gov)
  • Documenting the reverse diauxic phenotype in P. aeruginosa biofilms is foundational for understanding cellular nutrient and energy fluxes, which ultimately control growth and virulence. (nih.gov)
  • For some multidrug-resistant types of Pseudomonas aeruginosa , treatment options might be limited. (cdc.gov)
  • Doctors found that he had multidrug-resistant Pseudomonas aeruginosa keratitis . (naturalnews.com)
  • Pseudomonas is a type of bacteria (germ) that is found commonly in the environment, like in soil and in water. (cdc.gov)
  • Gram-negative bacteria including P. aeruginosa employ N -acyl homoserine lactones (AHLs) as chemical signals to regulate the expression of pathogenic phenotypes through a mechanism called quorum sensing (QS). (mdpi.com)
  • Pseudomonas aeruginosa is the gram negative rod shaped bacteria is found in all natural and man made environments. (ukessays.com)
  • Pseudomonas aeruginosa is a member of gamma proteobacteria class of bacteria. (ukessays.com)
  • Current study aimed to determination of inhibition ability of the probiotic bacteria (Lactobacillus fermentum) to inhibit P. aeruginosa adhesion. (sysrevpharm.org)
  • 5) Pseudomonas aeruginosa colonization is highly prevalent in the lungs of cystic fibrosis patients and leads to progressive pulmonary function decline and its eradication is particularly challenging. (pediatriconcall.com)
  • P. aeruginosa hypermutators have been frequently in cystic fibrosis patients, where they can facilitate the evolution of antimicrobial resistance. (nih.gov)
  • Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, Enterobacter species and extra-intestinal pathogenic Escherichia coli . (nih.gov)
  • Some strains of P. aeruginosa are resistant to most or all antibiotics, including aminoglycosides, cephalosporins, fluoroquinolones and carbapenems. (nih.gov)
  • Pseudomonas aeruginosa is an important Gram-negative pathogen with intrinsic resistance to many clinically used antibiotics. (warwick.ac.uk)
  • The primary end points were time to pulmonary exacerbation requiring intravenous antibiotics and proportion of P aeruginosa -positive cultures. (nih.gov)
  • The percentages of fluoroquinolone-resistant Pseudomonas aeruginosa and methicillin-resistant Staphylococcus aureus (MRSA) were obtained from yearly antibiograms at each hospital. (cdc.gov)
  • A number of case-control studies at individual hospitals have identified fluoroquinolone use as a risk factor for acquisition of fluoroquinolone-resistant P. aeruginosa and methicillin-resistant S. aureus (MRSA) ( 4 - 8 ). (cdc.gov)
  • We measured fluoroquinolone use as well as the percentages of MRSA and fluoroquinolone-resistant P. aeruginosa across 24 US hospitals during a 5-year period. (cdc.gov)
  • In December 2013, the P. aeruginosa was resistant to tobramycin and she was treated with oral ciprofloxacin and nebulized Colistin for 6 weeks. (pediatriconcall.com)
  • Compared with a nutrient-rich lab broth, saline or even plain water provide P. aeruginosa with an environment where it tends to become even more virulent and drug-resistant because it's adapting as a response to stress. (nih.gov)
  • Thus, CLEC5A is a promising therapeutic target to reduce ventilator-associated lung injury and fibrosis in P. aeruginosa-induced pneumonia. (sinica.edu.tw)
  • Association between mucosal barrier disruption by Pseudomonas aeruginosa exoproteins and asthma in patients with chronic rhinosinusitis. (physiciansweekly.com)
  • This work solves a decades-old question regarding the molecular basis underlying the chronic-to-acute switch in P. aeruginosa and suggests oxygen as a primary environmental driver of acute lethality. (bvsalud.org)
  • Using \textit{Pseudomonas aeruginosa} as a model organism, we investigate physical factors that either facilitate or restrict the swarming motility. (aps.org)
  • As of March 14, 68 individuals from 16 states have been infected with a rare strain of Pseudomonas aeruginosa , reported the Centers for Disease Control and Prevention (CDC). (naturalnews.com)
  • No difference in the rate of exacerbation or prevalence of P aeruginosa positivity was detected between cycled and culture-based therapies. (nih.gov)
  • This is the first study to report the prevalence of MDR P. aeruginosa isolated from residential sewage in Dutsin-Ma, Katsina State , Nigeria . (bvsalud.org)
  • She continued to have recurrent pneumonias due to P. aeruginosa for which she was on nebulized Colistin and finally succumbed to her disease in February 2018. (pediatriconcall.com)
  • Her sputum cultures subsequently grew Bukholderia cepacia, Streptococcus pneumoniae, Klebsiella pneumoniae and Pseudomonas aeruginosa over the next few months. (pediatriconcall.com)
  • Her sputum cultures continued to grow Pseudomonas aeruginosa on and off. (pediatriconcall.com)
  • P. aeruginosa activates CLEC5A to induce caspase-1-dependent NET formation, but it neither causes gasdermin D (GSDMD) cleavage nor contributes to P. aeruginosa-induced neutrophil death. (sinica.edu.tw)
  • Our aim was to evaluate the occurrence and antimicrobial resistance of P. aeruginosa in the water of swimming pools in northern Greece. (who.int)
  • Membrane lipid renovation in Pseudomonas aeruginosa ‐ implications for phage therapy? (warwick.ac.uk)
  • Pseudomonas aeruginosa belongs to a vast genus of obligate aerobic, non-fermenting, saprophytic, Gram-negative bacilli widespread in nature, particularly in moist environments such as water, sewage, soil, plants and animals [1]. (who.int)
  • Enhanced annotations and features for comparing thousands of Pseudomonas genomes in the Pseudomonas genome database. (pseudomonas.com)
  • The population of P. aeruginosa in the Philippines was diverse, with clonal expansions of XDR genomes belonging to multi-locus sequence types ST235, ST244, ST309, and ST773. (who.int)
  • Most bacterial species, including \textit{P. aeruginosa}, synthesize bio-surfactants to aid in swarming. (aps.org)
  • Staphylococcus aureus and Haemophilus Influenzae colonization is common during early childhood but ultimately Pseudomonas aeruginosa is isolated from CF patients due to impaired clearance directly induced by a defective CFTR gene. (pediatriconcall.com)
  • The aim is to determine the effect of P. aeruginosa exoproteins isolated from CF and non-CF CRS patients on the mucosal barrier. (physiciansweekly.com)
  • Gene deletion, mutagenesis, and complementation in P. aeruginosa identified ExoS bacterial toxin as the major factor involved in γH2AX induction. (inserm.fr)
  • This was further supported by long-read sequencing of one representative XDR isolate, which revealed the presence of an integron carrying multiple resistance genes, including bla VIM-2 , with differences in gene composition and synteny to other P. aeruginosa class 1 integrons described before. (who.int)
  • P. aeruginosa biofilm cultures preferentially consumed lactic acid over glucose, and in addition, the cultures catabolized the substrates completely and did not exhibit the acetate secreting "overflow" metabolism that is typical of many model microorganisms. (nih.gov)
  • Participants randomized to cycled therapy received tobramycin inhalation solution (300 mg twice a day) for 28 days, with oral ciprofloxacin (15-20 mg/kg twice a day) or oral placebo for 14 days every quarter, while participants randomized to culture-based therapy received the same treatments only during quarters with positive P aeruginosa cultures. (nih.gov)
  • The occurrence of MDR P. aeruginosa from a residential sewage site that may contaminate drinking water sources in the study area is of public health threat to the inhabitants. (bvsalud.org)
  • Univariate linear regression showed significant associations between a hospital's volume of fluoroquinolone use and percent resistance in most individual study years (1999-2001 for P. aeruginosa , 1999-2002 for S. aureus ). (cdc.gov)
  • Ecologic investigations across multiple hospitals have reported significant correlations between fluoroquinolone use and percent resistance for MRSA ( 9 ) and P. aeruginosa ( 10 , 11 ). (cdc.gov)
  • The potent activity of Epi-Otic against Pseudomonas is also of special interest in view of the increasing resistance shown by this genus against antimicrobials that may be used following cleansing agents in the therapy of otitis externa. (vin.com)
  • In this image, the Pseudomonas biofilm has grown in a laboratory dish to about the size of a dime. (nih.gov)
  • Planktonically grown Pseudomonas aeruginosa is known to prioritize the consumption of organic acids including lactic acid over catabolism of glucose using a CCR strategy termed "reverse diauxie. (nih.gov)
  • While pattern recognition receptors (PRRs) TLR4 and TLR5 are required for host defense against P. aeruginosa invasion, the PRR responsible for P. aeruginosa-induced NET formation, proinflammatory cytokine release, and acute lung injury remains unclear. (sinica.edu.tw)
  • We found that myeloid C-type lectin domain family 5 member A (CLEC5A) interacts with LPS of P. aeruginosa and is responsible for P. aeruginosa-induced NET formation and lung inflammation. (sinica.edu.tw)
  • Blockade of CLEC5A attenuates P. aeruginosa-induced NETosis and lung injury, and simultaneous administration of anti-CLEC5A mAb with ciprofloxacin increases survival rate and decreases collagen deposition in the lungs of mice challenged with a lethal dose of P. aeruginosa. (sinica.edu.tw)
  • Pseudomonas aeruginosa lives in the environment and can be spread to people in healthcare settings when they are exposed to water or soil that is contaminated with these germs. (cdc.gov)
  • Healthcare facilities should have water management plans (see Reduce Risk from Water ) that help ensure water quality and reduce the risk of exposure to potentially harmful germs like Pseudomonas aeruginosa . (cdc.gov)
  • The recalled eye drops were manufactured by Global Pharma Healthcare in India, where P. aeruginosa is often associated with hospital outbreaks. (naturalnews.com)
  • The researchers found that in the presence of glycans, P. aeruginosa was rendered less harmful and infectious. (nih.gov)
  • In their new study, published in Nature Microbiology , Ribbeck, lead author Kelsey Wheeler, and their colleagues studied mucus and its interactions with Pseudomonas aeruginosa . (nih.gov)
  • Generally the twitching motility of the P.aeruginosa helps to use its unipolar flagellum to adhere a surface. (ukessays.com)