An intense itching sensation that produces the urge to rub or scratch the skin to obtain relief.
Agents, usually topical, that relieve itching (pruritus).
Intense chronic itching in the anal area.
Intense itching of the external female genitals.
Oleagenous substances used topically to soothe, soften or protect skin or mucous membranes. They are used also as vehicles for other dermatologic agents.
A clinical syndrome associated with the retention of renal waste products or uremic toxins in the blood. It is usually the result of RENAL INSUFFICIENCY. Most uremic toxins are end products of protein or nitrogen CATABOLISM, such as UREA or CREATININE. Severe uremia can lead to multiple organ dysfunctions with a constellation of symptoms.
Drugs that bind to but do not activate histamine receptors, thereby blocking the actions of histamine or histamine agonists. Classical antihistaminics block the histamine H1 receptors only.
Impairment of bile flow due to injury to the HEPATOCYTES; BILE CANALICULI; or the intrahepatic bile ducts (BILE DUCTS, INTRAHEPATIC).
A chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. It is manifested by lichenification, excoriation, and crusting, mainly on the flexural surfaces of the elbow and knee. In infants it is known as infantile eczema.
The relief of pain without loss of consciousness through the introduction of an analgesic agent into the epidural space of the vertebral canal. It is differentiated from ANESTHESIA, EPIDURAL which refers to the state of insensitivity to sensation.
A plant genus of the family FABACEAE that is the source of mucuna gum.
Adverse cutaneous reactions caused by ingestion, parenteral use, or local application of a drug. These may assume various morphologic patterns and produce various types of lesions.
Therapy for the insufficient cleansing of the BLOOD by the kidneys based on dialysis and including hemodialysis, PERITONEAL DIALYSIS, and HEMODIAFILTRATION.
The elimination of PAIN, without the loss of CONSCIOUSNESS, during OBSTETRIC LABOR; OBSTETRIC DELIVERY; or the POSTPARTUM PERIOD, usually through the administration of ANALGESICS.
Impairment of bile flow due to obstruction in small bile ducts (INTRAHEPATIC CHOLESTASIS) or obstruction in large bile ducts (EXTRAHEPATIC CHOLESTASIS).
Compounds with activity like OPIATE ALKALOIDS, acting at OPIOID RECEPTORS. Properties include induction of ANALGESIA or NARCOSIS.
A class of non-sedating drugs that bind to but do not activate histamine receptors (DRUG INVERSE AGONISM), thereby blocking the actions of histamine or histamine agonists. These antihistamines represent a heterogenous group of compounds with differing chemical structures, adverse effects, distribution, and metabolism. Compared to the early (first generation) antihistamines, these non-sedating antihistamines have greater receptor specificity, lower penetration of BLOOD-BRAIN BARRIER, and are less likely to cause drowsiness or psychomotor impairment.
Treatment of disease by exposure to light, especially by variously concentrated light rays or specific wavelengths.
A name applied to several itchy skin eruptions of unknown cause. The characteristic course is the formation of a dome-shaped papule with a small transient vesicle on top, followed by crusting over or lichenification. (From Dorland, 27th ed)
Any of several generalized skin disorders characterized by dryness, roughness, and scaliness, due to hypertrophy of the stratum corneum epidermis. Most are genetic, but some are acquired, developing in association with other systemic disease or genetic syndrome.
An extremely variable eczematous skin disease that is presumed to be a response to prolonged vigorous scratching, rubbing, or pinching to relieve intense pruritus. It varies in intensity, severity, course, and morphologic expression in different individuals. Neurodermatitis is believed by some to be psychogenic. The circumscribed or localized form is often referred to as lichen simplex chronicus.
The principal alkaloid in opium and the prototype opiate analgesic and narcotic. Morphine has widespread effects in the central nervous system and on smooth muscle.
High-molecular-weight insoluble polymers that contain functional cationic groups capable of undergoing exchange reactions with anions.
Gastrointestinal agents that stimulate the flow of bile into the duodenum (cholagogues) or stimulate the production of bile by the liver (choleretic).
A group of disorders characterized by physical symptoms that are affected by emotional factors and involve a single organ system, usually under AUTONOMIC NERVOUS SYSTEM control. (American Psychiatric Glossary, 1988)
Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)
Messages between computer users via COMPUTER COMMUNICATION NETWORKS. This feature duplicates most of the features of paper mail, such as forwarding, multiple copies, and attachments of images and other file types, but with a speed advantage. The term also refers to an individual message sent in this way.
Mechanical food dispensing machines.
The guidelines and policy statements set forth by the editor(s) or editorial board of a publication.
The profession of writing. Also the identity of the writer as the creator of a literary production.
A publication issued at stated, more or less regular, intervals.
The functions and activities carried out by the U.S. Postal Service, foreign postal services, and private postal services such as Federal Express.
A loose confederation of computer communication networks around the world. The networks that make up the Internet are connected through several backbone networks. The Internet grew out of the US Government ARPAnet project and was designed to facilitate information exchange.
Compounds that interact with and modulate the activity of CANNABINOID RECEPTORS.
A subclass of cannabinoid receptor found primarily on central and peripheral NEURONS where it may play a role modulating NEUROTRANSMITTER release.
Fatty acid derivatives that have specificity for CANNABINOID RECEPTORS. They are structurally distinct from CANNABINOIDS and were originally discovered as a group of endogenous CANNABINOID RECEPTOR AGONISTS.
A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.
The outer covering of the body that protects it from the environment. It is composed of the DERMIS and the EPIDERMIS.
An idiopathic vascular disorder characterized by bilateral Raynaud phenomenon, the abrupt onset of digital paleness or CYANOSIS in response to cold exposure or stress.
A term used to describe a variety of localized asymmetrical SKIN thickening that is similar to those of SYSTEMIC SCLERODERMA but without the disease features in the multiple internal organs and BLOOD VESSELS. Lesions may be characterized as patches or plaques (morphea), bands (linear), or nodules.
A chronic multi-system disorder of CONNECTIVE TISSUE. It is characterized by SCLEROSIS in the SKIN, the LUNGS, the HEART, the GASTROINTESTINAL TRACT, the KIDNEYS, and the MUSCULOSKELETAL SYSTEM. Other important features include diseased small BLOOD VESSELS and AUTOANTIBODIES. The disorder is named for its most prominent feature (hard skin), and classified into subsets by the extent of skin thickening: LIMITED SCLERODERMA and DIFFUSE SCLERODERMA.
A mild form of LIMITED SCLERODERMA, a multi-system disorder. Its features include symptoms of CALCINOSIS; RAYNAUD DISEASE; ESOPHAGEAL MOTILITY DISORDERS; sclerodactyly, and TELANGIECTASIS. When the defect in esophageal function is not prominent, it is known as CRST syndrome.
A rapid onset form of SYSTEMIC SCLERODERMA with progressive widespread SKIN thickening over the arms, the legs and the trunk, resulting in stiffness and disability.
The least progressive form of SYSTEMIC SCLERODERMA with skin thickening restricted to the face, neck and areas distal to the elbows and/or knees, sparing the trunk. The CREST SYNDROME is a form of limited scleroderma.

Reduction of sodium deoxycholic acid-induced scratching behaviour by bradykinin B2 receptor antagonists. (1/789)

1. Subcutaneous injection of sodium deoxycholic acid into the anterior of the back of male ddY mice elicited dose-dependent scratching of the injected site with the forepaws and hindpaws. 2. Up to 100 microg of sodium deoxycholic acid induced no significant increase in vascular permeability at the injection site as assessed by a dye leakage method. 3. Bradykinin (BK) B2 receptor antagonists, FR173657 and Hoe140, significantly decreased the frequency of scratching induced by sodium deoxycholic acid. 4. Treatment with aprotinin to inhibit tissue kallikrein reduced the scratching behaviour induced by sodium deoxycholic acid, whereas treatment with soybean trypsin inhibitor to inhibit plasma kallikrein did not. 5. Although injection of kininase II inhibitor, lisinopril together with sodium deoxycholic acid did not alter the scratching behaviour, phosphoramidon, a neutral endopeptidase inhibitor, significantly increased the frequency of scratching. 6. Homogenates of the skin excised from the backs of mice were subjected to gel-filtration column chromatography followed by an assay of kinin release by trypsin from each fraction separated. Less kinin release from the fractions containing kininogen of low molecular weight was observed in the skin injected with sodium deoxycholic acid than in normal skin. 7. The frequency of scratching after the injection of sodium deoxycholic acid in plasma kininogen-deficient Brown Norway Katholiek rats was significantly lower than that in normal rats of the same strain, Brown Norway Kitasato rats. 8. These results indicate that BK released from low-molecular-weight kininogen by tissue kallikrein, but not from high-molecular-weight kininogen by plasma kallikrein, may be involved in the scratching behaviour induced by the injection of sodium deoxycholic acid in the rodent.  (+info)

Observations on the use of tetracycline and niacinamide as antipruritic agents in atopic dogs. (2/789)

Tetracycline and niacinamide were administered in combination to 19 atopic dogs to determine their effectiveness in controlling pruritus. The pruritus was controlled successfully in only one dog. One dog experienced diarrhea that was severe enough to warrant stopping the medication.  (+info)

Effects of prophylactic nalmefene on the incidence of morphine-related side effects in patients receiving intravenous patient-controlled analgesia. (3/789)

BACKGROUND: Opioid-related side effects associated with intravenous patient-controlled analgesia can be reduced by a low-dose naloxone infusion. The influence of nalmefene, a pure opioid antagonist with a longer duration of action, on opioid-related side effects has not been evaluated. This study was designed to determine the dose-response relation for nalmefene for the prevention of morphine-related side effects in patients receiving intravenous patient-controlled analgesia. METHODS: One hundred twenty women undergoing lower abdominal surgery were enrolled in the study. General anesthesia was induced using thiopental and rocuronium and maintained with desflurane, nitrous oxide, and fentanyl or sufentanil. All patients received neostigmine and glycopyrrolate to reverse residual neuromuscular blockade. No prophylactic antiemetics were administered. At the end of surgery, patients were randomized to receive saline, 15 microg nalmefene, or 25 microg nalmefene intravenously. The need for antiemetic and antipruritic drugs and the total consumption of morphine during the 24-h study were recorded. The incidences of postoperative nausea, vomiting, pruritus, and pain were recorded 30 min after patients were admitted to the postanesthesia care unit. In addition, patient remembrance of these side effects was noted at 24 h after operation. RESULTS: The need for antiemetic and antipruritic medications during the 24-h study period was significantly lower in the patients receiving nahmefene compared with those receiving placebo. However, the need to treat side effects was similar in the two nahmefene groups. Prophylactic administration of nalmefene reduced the patients remembrance of nausea and itching as assessed 24 h after operation. Although the total consumption of morphine during the 24-h study period was similar in the three groups, retrospectively patients who received nalmefene characterized their pain as less severe in the previous 24 h. CONCLUSION: Compared with placebo, prophylactic administration of nalmefene significantly decreased the need for antiemetics and antipruritic medications in patients receiving intravenous patient-controlled analgesia with morphine.  (+info)

Physical symptoms and quality of life in patients on chronic dialysis: results of The Netherlands Cooperative Study on Adequacy of Dialysis (NECOSAD) (4/789)

BACKGROUND: So far, little attention has been paid to the value of dialysis adequacy for patients' quality of life (QL). Therefore we studied the impact of demographic, clinical, and dialysis characteristics on physical symptoms and perceived QL. METHODS: The study population consisted of 120 incident chronic haemodialysis (HD) and 106 peritoneal dialysis (PD) patients, starting dialysis treatment in 13 Dutch centres. Data were collected 3 months after the start of dialysis. Nine physical symptoms were assessed with a self-administered questionnaire. Patient's self-assessment of QL was measured with the 36-item MOS Short Form (SF-36). RESULTS: The most common symptoms in HD and PD were fatigue (respectively 82 and 87%) and itching (73 and 68%). In HD only a medium to high comorbidity--age risk index was associated with greater symptom burden. In PD also a lower percentage lean body mass, a lower rGFR, and past episodes of underhydration were associated with greater symptom burden. The explained variance by these variables was only 12% in HD and 21% in PD. However, greater symptom burden explained a substantial additional amount of impaired physical and mental QL on top of demographics and clinical status. Dialysis variables were associated neither with symptoms nor with QL. CONCLUSION: Symptom burden can be explained to a limited extent by demographic and clinical variables and not by dialysis characteristics. Addition of symptom burden to the other variables makes it possible to explain one-third of perceived QL. This underlines the importance of symptom reduction in order to improve patient's QL.  (+info)

Comparison of intrathecal and epidural diamorphine for elective caesarean section using a combined spinal-epidural technique. (5/789)

To assess calculated equivalent doses of intrathecal and epidural opioids for elective Caesarean section in terms of quality and duration of analgesia, and incidence of side effects, we have compared 50 patients, allocated randomly to one of two groups to receive either diamorphine 0.25 mg intrathecally (group 1) or 5 mg epidurally (group 2), in addition to intrathecal bupivacaine 10 mg, using a combined spinal-epidural technique. There was no significant difference in duration of analgesia between groups (group 1 mean 14.6 (SD 5.9) h, group 2 14.2 (6.5) h; mean difference 0.8 h; 95% Cl -2.8-4.5; P = 0.65) or quality of analgesia (VAPS and VRS scores). The degree of pruritus was similar in both groups (80-88%) but the incidence of postoperative nausea and vomiting was significantly higher in the epidural group (24% vs 4%; P < 0.05). Intrathecal diamorphine 0.25 mg produced the same duration and quality of postoperative analgesia as epidural diamorphine 5 mg for elective Caesarean section but with significantly less nausea and vomiting.  (+info)

Allelic heterogeneity of dominant and recessive COL7A1 mutations underlying epidermolysis bullosa pruriginosa. (6/789)

The inherited mechanobullous disease, dystrophic epidermolysis bullosa, is caused by type VII collagen gene (COL7A1) mutations. We studied six unrelated patients with a distinct clinical subtype of this disease, epidermolysis bullosa pruriginosa, characterized by pruritus, excoriated prurigo nodules, and skin fragility. Mutation analysis using polymerase chain reaction amplification of genomic DNA, heteroduplex analysis and direct nucleotide sequencing demonstrated pathogenetic COL7A1 mutations in each case. Four patients had a glycine substitution mutation on one COL7A1 allele (G1791E, G2242R, G2369S, and G2713R), a fifth was a compound heterozygote for a splice site mutation (5532 + 1G-to-A) and a single base pair deletion (7786delG), and a sixth patient was heterozygous for an out-of-frame deletion mutation (6863del16). This study shows that the molecular pathology in patients with the distinctive clinical features of epidermolysis bullosa pruriginosa is heterogeneous and suggests that other factors, in addition to the inherent COL7A1 mutation(s), may be responsible for an epidermolysis bullosa pruriginosa phenotype.  (+info)

Patient-controlled analgesia: epidural fentanyl and i.v. morphine compared after caesarean section. (7/789)

We have compared patient-controlled epidural fentanyl (PCEF) and patient-controlled i.v. morphine (PCIM) after Caesarean section in 84 patients, in a randomized, double-blind study. All patients had an epidural and an i.v. patient-controlled analgesia (PCA) device, one of which delivered normal saline. Group PCEF received epidural fentanyl 20 micrograms with a 10-min lockout. Group PCIM received i.v. morphine 1 mg with a 5-min lockout. PCA use was lower for PCEF patients (P = 0.0007). The highest pain score recorded at rest for PCEF patients was median 20 (interquartile range 10-33) mm compared with 32 (14-52) mm for PCIM patients (P = 0.02). The highest pain score recorded on coughing was 31 (21-41) mm with PCEF compared with 56 (30-71) mm for PCIM (P = 0.001). There was less nausea (P = 0.02) and drowsiness (P = 0.0003) with PCEF. There was no difference in the overall incidence and severity of pruritus (P = 0.77). However, pruritus started earlier with PCEF.  (+info)

Management of opioid-induced pruritus: a role for 5-HT3 antagonists? (8/789)

We have evaluated the efficacy of ondansetron in the prevention of opioid-induced pruritus in a prospective, randomized, double-blind, placebo-controlled study. Using a 'human model' of opioid-induced pruritus, 80 ASA I-II patients about to undergo routine surgery were given either ondansetron 4 mg i.v. or 0.9% saline i.v. (40 in each group), 30 min before alfentanil 10 mg kg-1 i.v. During the following 5 min, patients were observed for signs of perinasal scratching and at 5 min were asked about symptoms of pruritus. The study was then terminated and anaesthesia was induced. There was a significant reduction in the incidence of scratching in patients receiving ondansetron compared with placebo (42.5% vs 70%, respectively, P = 0.013). The incidence of itching in the ondansetron group was less than that in the placebo group but this was not statistically significant (30% vs 42.5%, respectively, P = 0.245). We conclude that the 5-HT3 antagonist ondansetron may have a role in the management of opioid-induced pruritus.  (+info)

TY - JOUR. T1 - Five-year malignancy incidence in patients with chronic pruritus. T2 - A population-based cohort study aimed at limiting unnecessary screening practices. AU - Fett, Nicole. AU - Haynes, Kevin. AU - Propert, Kathleen Joy. AU - Margolis, David J.. PY - 2014/4. Y1 - 2014/4. N2 - Background: The incidence of malignancy in patients with chronic pruritus and nondiseased skin is unknown. Objective: We sought to assess the hazard ratio (HR) of incident overall malignancy and incident malignancy by subtype in patients with chronic pruritus during the 5 years after diagnosis. Methods: A population-based cohort study was performed in the Health Improvement Network. In all, 8744 patients with chronic pruritus were matched with 31,580 patients without chronic pruritus based on sex, age, and practice. Primary outcomes were HR of incident malignancy and HR of malignancy subtypes. Results: The fully adjusted HR for incident malignancy in patients with chronic pruritus was 1.14 (95% confidence ...
The severity of pruritus and the extent and severity of erythema were quantified in 107 dogs presenting with various dermatoses. Pruritus was assessed using a previously validated scale, and erythema was quantified by assessing severity at 72 different body sites. Pruritus scores were either 0, or followed a normal type of distribution, with most dogs having a score in the middle of the range and a few dogs having low or high scores. The median pruritus score was 6.3 ⁄ 10. Erythema scores were heavily skewed towards lower values, with only a few dogs having high scores. The median diffuse erythema score was 6.0 ⁄ 216 and the median score for maculo-papular ⁄ pustular erythema was 0 ⁄ 1080. Pruritus and erythema scores were significantly correlated with a Spearman rank correlation coefficient of 0.4062 (P , 0.001). However, visual assessment of the data representing the two variables revealed that this was not a consistent biological or clinically relevant correlation. Individual dogs ...
Background.. Uremic pruritus is still a common phenomenon in patients with end-stage renal failure. It is regarded as one of the most bothersome symptoms in patients on chronic dialysis.. The pathogenesis of uremic itch remains unclear. Several theories have been proposed like dryness of the skin, imbalance in divalent ions, peripheral neuropathy and others.. Many treatment modalities have been tried to reduce uremic pruritus, however , the majority of them produced only temporary improvement. Therefore , every new therapeutic option for uremic pruritus is desirable.. This study will undertaken to evaluate the efficacy of a cream which included olive oil and omega-3 fatty acids.. Olive Omega-3 is an efficient product that soothes itchiness of cracked and very dry skin.. The product is unique and based on patented technology developed by the Technion Research and Development Foundation in Haifa.. Olive Omega-3 is an ointment composed of all natural ingredients. The main active ingredients are ...
Background.. Uremic pruritus is still a common phenomenon in patients with end-stage renal failure. It is regarded as one of the most bothersome symptoms in patients on chronic dialysis.. The pathogenesis of uremic itch remains unclear. Several theories have been proposed like dryness of the skin, imbalance in divalent ions, peripheral neuropathy and others.. Many treatment modalities have been tried to reduce uremic pruritus, however , the majority of them produced only temporary improvement. Therefore , every new therapeutic option for uremic pruritus is desirable.. This study will undertaken to evaluate the efficacy of a cream which included olive oil and omega-3 fatty acids.. Olive Omega-3 is an efficient product that soothes itchiness of cracked and very dry skin.. The product is unique and based on patented technology developed by the Technion Research and Development Foundation in Haifa.. Olive Omega-3 is an ointment composed of all natural ingredients. The main active ingredients are ...
If your dog spends a large portion of his time scratching, he may have a condition known as pruritus, or itching, an unpleasant sensation that causes your dog to scratch or bite at himself. It is caused by chemical reactions that occur in the skin and stimulate the nerves, causing the brain to feel the itch. In fact, the act of scratching itself may stimulate these inflammatory reactions in the skin and make the condition worse. Any skin condition that causes inflammation can cause pruritus.. How pruritus affects your dogs health depends on the degree of the pruritus. Mild pruritus may hardly have any effect at all. However, severe pruritus leads to intense scratching, which may result in painful skin lesions that may become infected. Your dog will often whimper or cry out and may have trouble sleeping ...
Easy bruising Easy bruising: Add a 4th symptom Easy bruising: Remove a symptom Pruritus: Add a 4th symptom Pruritus: Remove a symptom Temperature symptoms: Temperature symptoms Temperature symptoms: Psoriasis psychosomatische Erkrankungen a 4th symptom Temperature symptoms: Remove a symptom Results: Causes of Easy bruising AND Pruritus AND Temperature symptoms 1.. Chronic lymphocytic leukemia 2. Aantibodies anti-FVIIIc syndrome 2. Abdominal cystic lymphangioma 8. Remove a symptom Start with new symptoms How this tool works Narrow Your Search: Add a 4 th Symptom Choose another medical symptom from the list below to search in addition to the already chosen symptoms to narrow the list of potential disease causes shown: Causes Medications causing Temperatur Pruritus bruising Diagnostic Guides Diagnosis Pruritus Introduction: Pruritus Causes of Pruritus Temperature symptoms Introduction: Temperature symptoms Causes of Temperature symptoms General Information: Hematoma causes Bruising causes Bleeding ...
TY - CHAP. T1 - Pruritus. AU - Weisshaar, Elke. AU - Yosipovitch, Gil. PY - 2014/8/11. Y1 - 2014/8/11. N2 - Pruritus, or itch, is a frequent symptom in dermatology, general practice, and other fields of medicine. Chronic itch usually forms a diagnostic and therapeutic challenge. In the last decade, significant advancement has been achieved in awareness for itch, and new epidemiological studies and treatments have been published. This chapter presents an overview of different forms of common systemic pruritus and their diagnostic measures and treatment options.. AB - Pruritus, or itch, is a frequent symptom in dermatology, general practice, and other fields of medicine. Chronic itch usually forms a diagnostic and therapeutic challenge. In the last decade, significant advancement has been achieved in awareness for itch, and new epidemiological studies and treatments have been published. This chapter presents an overview of different forms of common systemic pruritus and their diagnostic measures ...
Pruritus is a common and often incapacitating symptom in patients with advanced kidney disease. It can be challenging to treat, with only few proven therapeutic options. Aleckovic-Halilovic et al published an article on pruritus in a dialysis patient in AJKD. Complete our nephrology jumble-bumble to test your knowledge on uremic pruritus! …
Definition of pruritus in the Legal Dictionary - by Free online English dictionary and encyclopedia. What is pruritus? Meaning of pruritus as a legal term. What does pruritus mean in law?
Histopathologic examination with Giemsa staining showed a dense infiltrate of mast cells (MCs) in the superficial dermis. These findings, in combination with hi
To our knowledge, this is the first study to investigate the association of pruritus with QOL and disability in SSc. The presence of pruritus on most days in the past month was significantly associated with poorer mental and physical function and greater disability, with a small effect size difference for disability and medium effect size differences for mental and physical health. Typically, a medium standardized difference effect size (approximately 0.50) is considered to be clinically meaningful (41). After controlling for sociodemographic and other disease variables, the presence of pruritus was significantly associated with mental and physical health, but not disability. The magnitude of the independent association of pruritus with QOL outcomes in multivariate analyses was small, but it is notable that it was significantly associated with QOL even after controlling for a large number of variables known to have robust associations with QOL and disability in SSc.. The results of this study ...
Aquagenic pruritus is a skin condition characterized by the development of severe, intense, prickling-like epidermal itching without observable skin lesions and evoked by contact with water. Symptoms occur for up to 35 minutes; duration of an attack is typically between 10 and 120 minutes. However, sensitivity varies among sufferers, and since water is always present to some extent in the air (atmospheric humidity), those with greater sensitivity who live in moister regions are symptomatic almost constantly, while perspiration can cause frequent symptoms even in the driest climates. No definitive medical test is known for aquagenic pruritus. Rather, the diagnosis is made by excluding all other possible causes of the patients itching. Some of which includes polycythemia vera. Since pruritus is a symptom of many serious diseases, it is important to rule out other causes before making a final diagnosis. The name is derived from Latin: aquagenic, meaning water-induced, and pruritus, meaning itch. ...
Symptoms of Brachioradial pruritus including 9 medical symptoms and signs of Brachioradial pruritus, alternative diagnoses, misdiagnosis, and correct diagnosis for Brachioradial pruritus signs or Brachioradial pruritus symptoms.
The Pruritus Therapeutics Market report presents a calculated opinion of the analyzed Pruritus Therapeutics Market data. It explains various opportunities dedicated to different industries, suppliers, organizations, and associations offering various products and services such as offering them precise guidance for their expansion in the competition for reliable services to consumers. The report provides detailed information on key competitors in the market and on emerging companies with significant market share based on demand, revenue, sales, high-quality product manufacturers, and service providers.. Request Brochure of this Pruritus Therapeutics Market Report For More Industry Insights @ CLICK HERE NOW. Analysis based on competence and estimation of the global Pruritus Therapeutics Market is crafted through assessable methods to attain a clear insight of current and expected growth patterns. The report also contains the market distribution based on the geographical location around the globe ...
in nociceptors expressing transient receptor potential vanilloid 1 (TRPV1). BRAFNav1.8 mice showed de novo neuronal responsiveness to pruritogens, enhanced pruriceptor excitability, and heightened evoked and spontaneous scratching behavior. GRP receptor expression was increased in the spinal cord, indicating augmented coding capacity for itch subsequent to amplified pruriceptive inputs. Enhanced GRP expression and sustained ERK phosphorylation were observed in sensory neurons of mice with allergic contact dermatitis- or dry skin-elicited itch; however, spinal ERK activation was not required for maintaining central sensitization of itch. Inhibition of either BRAF or GRP signaling attenuated itch sensation in chronic itch mouse models. These data uncover RAF/MEK/ERK signaling as a key regulator that confers a subset of nociceptors with pruriceptive properties to initiate and maintain long-lasting itch sensation. ...
in nociceptors expressing transient receptor potential vanilloid 1 (TRPV1). BRAFNav1.8 mice showed de novo neuronal responsiveness to pruritogens, enhanced pruriceptor excitability, and heightened evoked and spontaneous scratching behavior. GRP receptor expression was increased in the spinal cord, indicating augmented coding capacity for itch subsequent to amplified pruriceptive inputs. Enhanced GRP expression and sustained ERK phosphorylation were observed in sensory neurons of mice with allergic contact dermatitis- or dry skin-elicited itch; however, spinal ERK activation was not required for maintaining central sensitization of itch. Inhibition of either BRAF or GRP signaling attenuated itch sensation in chronic itch mouse models. These data uncover RAF/MEK/ERK signaling as a key regulator that confers a subset of nociceptors with pruriceptive properties to initiate and maintain long-lasting itch sensation. ...
in nociceptors expressing transient receptor potential vanilloid 1 (TRPV1). BRAFNav1.8 mice showed de novo neuronal responsiveness to pruritogens, enhanced pruriceptor excitability, and heightened evoked and spontaneous scratching behavior. GRP receptor expression was increased in the spinal cord, indicating augmented coding capacity for itch subsequent to amplified pruriceptive inputs. Enhanced GRP expression and sustained ERK phosphorylation were observed in sensory neurons of mice with allergic contact dermatitis- or dry skin-elicited itch; however, spinal ERK activation was not required for maintaining central sensitization of itch. Inhibition of either BRAF or GRP signaling attenuated itch sensation in chronic itch mouse models. These data uncover RAF/MEK/ERK signaling as a key regulator that confers a subset of nociceptors with pruriceptive properties to initiate and maintain long-lasting itch sensation. ...
Itching is an unpleasant sensation associated with the desire to scratch, and the itch sensation is an important protective mechanism for animals. However, chronic itch, often seen in patients with skin and liver diseases, ...
The mechanisms that generate itch are poorly understood at both the molecular and cellular levels despite its clinical importance. To explore the peripheral neuronal mechanisms underlying itch, we assessed the behavioral responses (scratching) produced by s.c. injection of various pruritogens in PLCbeta3- or TRPV1-deficient mice. We provide evidence that at least 3 different molecular pathways contribute to the transduction of itch responses to different pruritogens: 1) histamine requires the function of both PLCbeta3 and the TRPV1 channel; 2) serotonin, or a selective agonist, alpha-methyl-serotonin (alpha-Me-5-HT), requires the presence of PLCbeta3 but not TRPV1, and 3) endothelin-1 (ET-1) does not require either PLCbeta3 or TRPV1. To determine whether the activity of these molecules is represented in a particular subpopulation of sensory neurons, we examined the behavioral consequences of selectively eliminating 2 nonoverlapping subsets of nociceptors. The genetic ablation of MrgprD(+) ...
Itching (pruritus) is a common symptom associated with numerous skin diseases, as well as a secondary symptom of numerous serious conditions such as renal failure and liver disease. Itching, unlike other skin sensations, is generally a result of CNS activities and typically goes untreated by standard medical therapies.. The endocannabinoid system is acknowledged to play an important role in maintaining skin health[1] and cannabinoids have been regarded as promising agents for the treatment of itch.[2]. A review of the scientific literature identifies at least three clinical trials investigating the use of cannabinoids in the treatment of pruritus. Writing in the August 2002 issue of the American Journal of Gastroentrology, investigators from the University of Miami Department of Medicine reported successful treatment of pruritus with 5 mg of THC in three patients with cholestatic liver disease.[3] Prior to cannabinoid therapy, subjects had failed to respond to standard medications and had lost ...
A recent study carried out by Dr. Sun Yangangs lab at the Institute of Neuroscience of the Chinese Academy of Sciences discovered a central neural circuit that is critical for transmitting the itch signal. By using optogenetic, chemogenetic, patch clamp recording, and in vivo fiber photometry techniques, the researchers demonstrated that the spino-parabrachial pathway plays a key role in transmitting itch signals from the spinal cord to the brain, and identified the parabrachial nucleus as a first central relay for the itch sensation.
Pruritus - Pipeline Review, H1 2017, provides an overview of the Pruritus (Dermatology) pipeline landscape. Pruritus, or itch, is defined as an unpleasant
1 Pisoni RL, Wikstrom B, Elder SJ, Akizawa T, 5 Razeghi E, Eskandari D, Ganji MR, Meysamie 10 Lee SH, Baig M, Rusciano V, Dutcher JP: Asano Y, Keen ML, Saran R, Mendelssohn AP, Togha M, Khashayar P: Gabapentin and Novel management of pruritus in patients DC, Young EW, Port FK: Pruritus in haemo- uremic pruritus in hemodialysis patients. Ren treated with IL-2 for metastatic renal cell car- dialysis patients: international results from Fail 2009; 31: 85-90. cinoma and malignant melanoma. J Immu- the Dialysis Outcomes and Practice Patterns 6 Aperis G, Paliouras C, Zervos A, Arvanitis A, notherapy 2010; 33: 1010-1013. Study (DOPPS). Nephrol Dial Transplant Alivanis P: The use of pregabalin in the treat- 11 Bergasa NV, McGee M, Ginsburg IH, Engler 2006; 21: 3495-3505. ment of uraemic pruritus in haemodialysis D: Gabapentin in patients with the pruritus of 2 Gunal AI, Ozalp G, Yoldas TK, Gunal SY, patients. J Ren Care 2010; 36: 180-185. cholestasis: a double-blind, randomized, pla- Kirciman E, Celiker ...
Pruritus is a debilitating symptom that can be associated with cutaneous involvement by an underlying malignancy. We report the case of a 68-year-old woman with a history of triple-negative breast cancer who presented with extensive, localised cutaneous metastasis complicated by incapacitating, treatment-refractory pruritus localised to the anatomic regions involved by her metastatic disease. Physical examination revealed an indurated, ecchymotic, ulcerated plaque circumferentially encasing her thorax. Histopathological examination revealed substantial dermal lymphatic involvement and dilation as well as dermal collagen infiltration by tumour cells and nodules. The clinical and pathological findings were consistent with a diagnosis of carcinoma en cuirasse. Mirtazapine, a noradrenergic antidepressant with antiserotonin and antihistamine activity, was started and led to rapid, sustained relief of the patients pruritus. Mirtazapine may be a useful systemic agent for the palliative relief of ...
Find the best vaginal pruritus doctors in Thane. Get guidance from medical experts to select vaginal pruritus specialist in Thane from trusted hospitals - credihealth.com
Itch is an unpleasant sensation that evokes behavioral responses such as scratching the skin. Interestingly, it is conceived that the perception of itch sensation is influenced by age. Indeed, accumulating evidence supports the idea that even children or younger adults show distinctive itch sensation depending on age. This evidence implies the presence of a mechanism that regulates the perception of itch sensation in an age-dependent fashion. Therefore, the purpose of the present study was to investigate a putative mechanism for the age-dependent perception of itch sensation by comparing histamine-induced scratching behaviors in 45-day old (D45) and 75-day old male young adult mice ...
A new study has shown that Gabapentin can be an effective drug against uremic pruritus suffered by patients with advanced chronic kidney disease. The study was also suggested that Gabapentin may also be the only effective drug against it. (1). Uremic pruritus is a disease characterized by continuous bouts of itching throughout the body. It often worsens during the night causing patients sleeplessness or insomnia. Separate studies have shown that almost 46% of patients undergoing dialysis suffer from uremic pruritus.. This comes after the research team claimed that other treatments tested for the disease were weak and limited by small studies with a high risk of bias. The team was led by Claudio Rigatto, MD, MSc, of the University of Manitoba in Winnepeg, Canada. Their statement was reported online ahead of print in the American Journal of Kidney Diseases.. The study was conducted by assessing patients with chronic kidney disease, stage 3 or higher, or undergoing any form of dialysis on 44 ...
Hypothesis: Pruritus or itch is the most common skin symptom in elderly patients and is estimated to affect more than 30% of nursing home patients. Clinical and experimental evidence suggests pruritus in elderly patients may be linked to pemphigoid. Pemphigoid is the most common autoimmune skin blistering diseases and mainly affects the elderly. It is successfully treatable with systemic therapy. However, pemphigoid is often missed as a cause of pruritus in elderly patients. Although nursing home patients and patients with dementia in particular have the highest risk for development of pemphigoid, no study has been performed in this population so far. Including serological screening for pemphigoid in the diagnostic evaluation of chronic pruritus in nursing home patients may lead to the diagnosis of pemphigoid. Furthermore, chronic itch may be an unrecognized cause of neuropsychiatric symptoms in nursing home patients with dementia ...
suffer from chronic cough with approximately 3 million having refractory chronic cough lasting for more than a year and approximately 6 million having refractory chronic cough lasting more than 8 weeks and under one year. It is estimated that approximately 55% of patients have mild disease, and approximately 45% have moderate to severe disease. There is no specific therapy approved for refractory chronic cough and current treatment options are limited. Chronic pruritus, commonly known as chronic itch, is an irritating sensation that leads to scratching, and persists for longer than six weeks, which can be debilitating and has a significant impact on quality-of-life. It is a hallmark of many conditions, including atopic dermatitis (AD). It is estimated that chronic pruritus associated with AD affects more than 16.9 million adults in ...
suffer from chronic cough with more than 2.6 million having refractory chronic cough lasting for more than a year. There is no specific therapy approved for refractory chronic cough and treatment options are limited. Chronic pruritus, commonly known as chronic itch, is an irritating sensation that leads to scratching, and persists for longer than six weeks, which can be debilitating and has a significant impact on quality-of-life. It is a hallmark of many conditions, including atopic dermatitis (AD). It is estimated that chronic pruritus associated with AD affects more than 16.9 million adults in ...
Introduction : Pruritus is a common and troublesome side effect of end stage renal disease. It can directly influences on quality of life in affected patients. Unfortunately present treatment options are not successful in alleviating this symptom and yet kidney transplantation is the best option. Since one of the recent therapies in ...
BioMed Research International is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies covering a wide range of subjects in life sciences and medicine. The journal is divided into 55 subject areas.
Here, we identify the BRAF pathway as an upstream regulator of expression of a cohort of itch mediators in mouse sensory neurons. Our data further demonstrate that GRP/GRPR signaling plays an important role in the initiation and maintenance of long-lasting itch in 3 distinct genetic and/or clinically relevant chronic itch models. Finally, our data suggest that a phenotypic switch from nociceptors to pruriceptors underlies the transition from acute itch signaling to pathological itch state.. BRAFNav1.8 mice are a new and unique genetic model for unraveling how pruriceptive transmission is progressively enhanced at the molecular and circuit levels, as increasing scratching behavior correlates well with an expression profile change of itch mediators. The fact that enhanced evoked scratching preceded the manifestation of spontaneous itch (from 3 weeks of age to around 6 weeks of age) suggests the existence of a postnatal period for developmental maturation of itch circuitry as well as a threshold ...
Background Patients who suffer from chronic itch employ creative techniques to alleviate their itch, often using painful thermal stimuli, such as hot and very cold showers, as well as mechanical stimuli, such as scratching.. Objectives The present study examined whether the sensory perception of itch is attenuated by remote interactions between both thermal and mechanical stimuli and afferent information related to itch.. Patients and methods Itch was induced with histamine iontophoresis in 21 healthy young subjects. Repetitive thermal stimuli including innocuous warmth, innocuous cool, noxious cold and noxious heat as well as scratching were applied 3-cm distal to the area of histamine iontophoresis. Subjects rated their perceived intensity of histamine-induced itch with a computerized visual analogue scale.. Results Itch intensity ratings were significantly reduced during each period of scratching and repeated noxious heat and cold. Innocuous cooling and warming did not significantly alter ...
Taiho Pharmaceutical Co., Ltd. (HQ: Tokyo, President: Toru Usami) announced today that the licensing agreement with Nippon Shinyaku Co., Ltd. (HQ: Kyoto, President: Shigenobu Maekawa) for the new NST-141 agent for pruritus in atopic dermatitis has been cancelled by mutual consent.. Discovered by Nippon Shinyaku Co., Ltd., NST-141 is a new antipruritic agent for external administration. The said agreement covering joint development and collaborative marketing in Japan had been concluded on October 1, 2008.. ...
There does not appear to be any one underlying cause for delusional parasitosis, although it probably has to do with fundamental aspects of brain chemistry. This syndrome is often classified into three types according to the underlying condition as below. However, there is increasing literature on itch and chronic pruritus (itch) that indicate that delusional parasitosis may not be a psychiatric syndrome per se and instead may have a fundamental origin in the itch nerve pathways between the skin and the brain. There are many physiological syndromes that cause the symptoms ascribed to delusional parasitosis.. Delusional Infestation and Chronic Pruritus: A Review Primary Psychotic Delusional Parasitosis ...
Patients suffering from cholestasis often report experiencing a debilitating, unrelenting itch. In contrast to conditions, such as urticaria, in which histamine primarily drives itch (pruritus), cholestatic pruritus is multifactorial and more difficult to treat. Existing therapies are not always eff …
Cholestatic pruritus is the sensation of itch due to nearly any liver disease, but the most commonly associated entities are primary biliary cirrhosis, primary sclerosing cholangitis, obstructive choledocholithiasis, carcinoma of the bile duct, cholestasis (also see drug-induced pruritus), and chronic hepatitis C viral infection and other forms of viral hepatitis. Cholestasis means the slowing or stopping of bile flow which can be caused by any number of diseases of the liver (which produces the bile), the gallbladder (which stores the bile), or biliary tract (also known as the biliary tree, the conduit that allows the bile to leave the liver and gallbladder and enter the small intestine). When this occurs, conjugated bilirubin and the waste products that usually would be cleared in bile reflux back into the bloodstream. This causes a primarily conjugated hyperbilirubinemia and jaundice; the liver conjugates the bile to make it water-soluble and because the bile has already been processed by ...
The report segments the pruritus therapeutics market on the basis of type, disease type and geography. Pruritus is a chronic itching condition caused due to dermatological disease including atopic dermatitis, contact dermatitis, mycoses, chickenpox etc.
Pruritus Therapeutics Market - The report covers forecast and analysis for the pruritus therapeutics market on a global and regional level. The study provi
Pruritus or itching is defined as skin condition being marked with itching and dryness. Here is a rundown of causes, symptoms and prevention of pruritus.
Introduction: Neuropathy is a frequent complication of uremic disease, causing motor and sensorial symptoms, mostly localized in the lower limbs. Another symptom related to uremic disease is pruritus, which may be diffuse all over the body, but usually occurring in the lower limbs. In the terminal phase therapeutic measures are taken, targeting the sensitive components of neuropathy, with the use of drugs against pain, and targeting itching, using different substances, the most widely used of which is gabapentin.Methods: The severity of neuropathy is variable, ranging from slight to severe and may or may not be associated with the length of chronic dialysis treatment. The use of measurement scales of pain, VAS type adapted to the itching, may link both conditions of neuropathy and itching. Results: We noted that a severe intensity of pruritus can be related to severity of neuropathy in uremic subjects and may become predictive of progressing neuropathy.Conclusions: In this study we examined a group
Pruritus is a common presenting symptom in primary care medicine that can prove distressing to the patient and frustrating for the treating doctor. Here is a practical approach to the diagnosis of its causes and its management, including a discussion of some less familiar conditions in which pruritus is a feature.. ...
Feeling PRURITUS while using Metformin? PRURITUS Causes, Patient Concerns and Latest Treatments and Metformin Reports and Side Effects.
Feeling PRURITUS while using ACIPHEX? PRURITUS Causes, Patient Concerns and Latest Treatments and ACIPHEX Reports and Side Effects.
View details of top pruritus hospitals in New Delhi. Get guidance from medical experts to select best pruritus hospital in New Delhi
Itchy feet also called pruritus, refers to a condition in which there is a tickling or irritating sensation in the feet with an urge to scratch. This may be accompanied by redness, soreness, flaking or scarring in the affected region. Although most cases of foot itch are not of serious concern, itching feet can indicate…
Itching of the anus is a common condition afflicting up to 5% of the population.2 The incidence of primary and secondary pruritus ani varies among different studies. Several studies show that the incidence of idiopathic pruritus ani is 75-95%.9 Other authors have found that its incidence is only 25%.10 Characteristically, pruritus ani is exacerbated by friction or a warm moist perineal environment. Poor anal hygiene or, in contrast, overcleansing with soap is often a contributing factor. Patients with idiopathic pruritus ani have been found to have abnormal transient internal sphincter relaxation11 and an abnormally profound decrease in anal canal pressure during rectal distention, as well as early incontinence on saline continence tests, implying that intermittent seepage from the anal canal may be a causative factor.12 A decrease in resting anal canal pressure with coffee intake has also been reported13 which may explain the documented exacerbation of symptoms with ingestion of caffeine. ...
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What are the aims of this leaflet?. This leaflet has been written to help you understand more about pruritus which means itching. It tells you what it is, what its causes are, what can be done about it, and where you can find out more information about it. This leaflet does not specifically cover itch in children or pruritus in pregnancy.. What is pruritus?. Pruritus (itching) refers to a sensation of the skin which causes a desire to scratch.. Itching is a normal body response to protect us from harmful external substances or parasites such as insect bites. However, pruritus (or itch) is a common and distressing symptom of many skin diseases, systemic illnesses and psychological disorders.. Itch is perhaps the commonest presenting symptom of skin disorders. In any two week period, 8-9% of the population suffer from significant pruritus. Pruritus lasting more than 6 weeks is called chronic pruritus. Pruritus may be localised to one area or generalized all over the skin.. What causes pruritus ...
1152 attendants comprising 40% mole and 60% female subjects at urban private clinics and rural health centres in Ghana were interviewed by questionnaire. Enquiry was made into the occurrence of chloroquine-induced pruritus in themselves, their spouses, their children, their siblings and their parents. The questionnaire included the following details:- (a) self-medication for febrile illnesses (b) the number of tablets of chloroquine that induced pruritus. (c) the time of onset and duration of pruritus (d) the method of relief of pruritus 44.8% of respondents had experienced itching on taking chloroquine. 23.3% itched on being given chloroquine intramuscularly and 95% of these itched on oral chloroquine. The rate of itching on self-medication with chloroquine alone or with other drugs was 41%. 33.9% itched each time they took chloroquine and 30.9% itched at least once after taking chloroquine. The prevalence rate of chloroquine induced pruritus in this study was found to be between 30. 9% and ...
This dose-escalation study assessed the safety, tolerability, and pharmacokinetics of oral nalbuphine in haemodialysis patients with uremic pruritus. This study
Another name for Pruritus Vulvae is Pruritus Vulvae. The treatment for pruritus vulvae depends on the cause. Treatment for pruritus vulvae may include ...
Science 24 May 2013: Vol. 340 no. 6135 pp. 968-971 The Cells and Circuitry for Itch Responses in Mice. Santosh K. Mishra, Mark A. Hoon. Molecular Genetics Unit, Laboratory of Sensory Biology, National Institute of Dental and Craniofacial Research (NIDCR), NIH, Building 49, Room 1A16, 49 Convent Drive, Bethesda, MD 20892, USA.. [paraphrase]. Itch is triggered by somatosensory neurons expressing the ion channel TRPV1 (transient receptor potential cation channel subfamily V member 1), but the mechanisms underlying this nociceptive response remain poorly understood. Here, we show that the neuropeptide natriuretic polypeptide b (Nppb) is expressed in a subset of TRPV1 neurons and found that Nppb−/− mice selectively lose almost all behavioral responses to itch-inducing agents. Nppb triggered potent scratching when injected intrathecally in wild-type and Nppb−/− mice, showing that this neuropeptide evokes itch when released from somatosensory neurons. Itch responses were blocked by ...
Being one of the most common dermatological problems, pruritus ani is often defined as an unpleasant skin sensation. Though it is not a life threatening ailment, yet the great urge to scratch which occurs due to this problem is highly irritating. Find out in detail about the causes and treatment here. What does the term pruritus means? Basically, it is a medical term which refers to itching… which can make you feel worse at anytime of the day! Do you know it can results in damage and scarring on the skin surface? Yes, due to the damage of the skin surface, it then serves as an entry point for the microbes. Hence, increasing the chances of infection by manifold! As far as the occurrence of pruritus on the skin is concerned, it might be caused due anything ranging from mild skin disorder to a highly serious systemic disease condition. And on the other hand, irritation or itching may be induced due to any material, when the infested come into contact physically. Now the question arises;What is
Lateral habenula (LHb) is a brain region acting as a hub mediating aversive response against noxious, stressful stimuli. Growing evidences indicated that LHb modulates aminergic activities to induce avoidance behavior against nociceptive stimuli. Given overlapped neural circuitry transmitting pain and itch information, it is likely that LHb have a role in processing itch information. Here, we examined whether LHb is involved in itchy response induced by histamine. We found that histamine injection enhances Fos (+) cells in posterior portion within parvocellular and central subnuclei of the medial division (LHbM) of the LHb. Moreover, chemogenetic suppression of LHbM reduced scratching behavior induced by histamine injection. These results suggest that LHb is required for processing itch information to induce histaminergic itchy response.
TY - JOUR. T1 - Psychological management of wound pruritus. AU - UPTON, Dominic. AU - Penn, F. AU - Richardson, Cliff. AU - Rippon, Mark. PY - 2014. Y1 - 2014. N2 - Objective: To explore the psychological treatment options for pruritus in patients with wounds. Method: This study employed a narrative design with a search being completed using the databases Academic Search Complete, Google Scholar, PsycInfo, PsycARTICLES, Medline and CINAHL Plus. All articles between 1980-2013 that included the following search terms: [pruritus OR itch OR itching] AND [management OR psychological interventions OR treatment] AND [wounds OR burns OR wounds burns] wre included in the review. Results: A number of psychological treatments options merged from the literature search that were suggested to be effective for treating itching. These included methods such as habit reversal, suggestions, relaxation, massage and itch-coping programmes. Each of these methods showed potential for improving the patient experience ...
Title:RELIEF OF THE PRURITUS OF JAUNDICE WITH METHANDROSTENOLONE AND SPECULATIONS ON THE NATURE OF PRURITUS IN LIVER DISEASE.,Author:ALVA J,IBER F L,Journal:Am J Med Sci,1965/7;250:60-5.,Publication t...
WELTER, Elisângela de Quevedo et al. Relationship between pruritus and quality of life in patients on hemodialysis. An. Bras. Dermatol. [online]. 2008, vol.83, n.2, pp.137-140. ISSN 0365-0596. http://dx.doi.org/10.1590/S0365-05962008000200006.. INTRODUCTION: Pruritus is a frequent symptom affecting patients on hemodialysis. Its etiology is not known and treatment is difficult. This symptom considerably worsens the patients quality of life. OBJECTIVES: To evaluate the degree of pruritus and its influence on the quality of life of patients on hemodialysis. METHODS: Patients with chronic renal disease on hemodialysis and presenting pruritus in a Hospital of Porto Alegre were enrolled in this transversal study. A visual analogue scale for measuring the degree of pruritus was used and the Dermatology Life Quality Index questionnaire was applied. RESULTS: Of 200 evaluated patients; 69 (34.5%) presented pruritus, of whom 16 (23%) of mild degree, 39 (56.5%) moderate, 14 (20.2%) severe. Quality of life ...
Rifampicin is a semisynthetic antibiotic derived from the rifamycins, a group of antibacterials produced by Streptomyces mediterranei. Rifampicin was initially developed to treat tuberculosis but more recently has been used against other bacteria. The beneficial effect of rifampicin on pruritus was initially discovered serendipitously. Four formal studies (three of which were randomised controlled trials) have suggested a subjective effect of rifampicin on itch severity.10-13 These studies also suggested that rifampicin was better at relieving itch than other hepatic enzyme inducing agents such as phenobarbitone.10 A single small study failed to confirm the effectiveness of rifampicin for subjective itching in cholestatic liver disease (including three patients with PBC).18 All of these studies used subjective measures of itch severity (for example, visual analogue scales). To our knowledge no trial of rifampicin in cholestasis has examined efficacy in terms of objective changes in scratching ...
TY - JOUR. T1 - Treatment of atopic dermatitis. AU - Han, Tae Young. AU - Na, Chan Ho. AU - Lee, Ji Hyun. AU - Kim, Hye One. AU - Park, Chang Ook. AU - Seo, Young Joon. AU - Son, Sang Wook. AU - Shin, Min Kyung. AU - Ahn, Ji Young. AU - Lee, Yang Won. AU - Jang, Yong Hyun. AU - Park, Young Lip. AU - Lew, Bark Lynn. PY - 2018/12/1. Y1 - 2018/12/1. N2 - Atopic dermatitis (AD) is a common, chronic, relapsing, inflammatory skin disease that affects both children and adults. AD is the cause of considerable morbidity including severe pruritus and impaired quality of life. Treatments for active disease include avoidance of triggering factors, barrier repair, topical medications including topical corticosteroids (TCs) and topical calcineurin inhibitors (TCIs), phototherapy, antibacterial agents, and systemic immunosuppressants including cyclosporine. Until recently, the only Food and Drug Administration (FDA)-approved systemic treatment options for patients with moderate-to-severe AD were steroids and ...
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Lausanne - July 25, 2017- Galderma announced today the enrollment of the first patient in a multicenter double-blind Phase IIb clinical trial to evaluate nemolizumab, its investigational subcutaneous anti-IL-31 receptor A (RA) monoclonal antibody, in patients with atopic dermatitis (AD). The trial is designed to assess the efficacy of nemolizumab in moderate-to-severe AD subjects with severe pruritus receiving topical corticosteroids, who were not adequately controlled with topical treatments. Patients will be randomized to receive one of three active doses of nemolizumab or placebo administered once a month for 6 months. The safety, tolerability and pharmacokinetics of nemolizumab will also be assessed in this study ...
Urticaria (hives) is a vascular reaction of the skin marked by the transient appearance of smooth, slightly elevated patches (wheals) that are erythematous and that are often attended by severe pruritus. Individual lesions resolve without scarring in several hours.
Shire plc today announced that the 13-week Phase 2 IMAGO trial of its investigational compound SHP625 (LUM001) did not meet the primary or secondary endpoints in the study of 20 pediatric patients with Alagille syndrome (ALGS), a rare, life-threatening genetic disorder that presents with chronic cholestasis (accumulation of bile acids in the liver) and severe pruritus (itching).
When youre hungry and in need of a quick snack, simply heat up some ghee, toss in some bananas, and watch them sizzle. A dash of spices, cinnamon and ginger, make these morsels quite delicious! This rich, nourishing snack couldnt be easier to make or ...
Introduction : Atopic dermatitis (AD) is a chronic and relapsing inflammatory skin disease, characterized by eczematous skin lesions and intensive pruritus. Recent studies have shed light on the role of the nervous system in the pathogenesis of AD. It can influence the course of the disease...
List of 36 causes for Abdomen blister and Pruritus in children and Skull itch, alternative diagnoses, rare causes, misdiagnoses, patient stories, and much more.
When Hemorrhoids Itch Are They Healing? Itching is one of the most common symptoms. In most cases, hemorrhoids itch because of mucus, feces and bad hygiene not because they are healing. In most cases, proper early treatment can take care of the condition.
Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Potently activated by enkephalins including BAM22 (bovine adrenal medulla peptide 22) and BAM (8-22)(PubMed:26582731). BAM22 is the most potent compound and evoked a large and dose-dependent release of intracellular calcium in stably transfected cells. G(alpha)q proteins are involved in the calcium-signaling pathway. Activated by the antimalarial drug, chloroquine. May mediate chloroquine-induced itch, in a histamine-independent manner.
List of 53 causes for Hand and foot rashes due to skin disorders in children and Itchy scalp and Pruritus ani and Scabs, alternative diagnoses, rare causes, misdiagnoses, patient stories, and much more.
Other medications that may provide relief against pruritus in addition to antihistamines (eg, diphenhydramine, hydroxyzine) and ammonium lactate 12% skin cream (Lac-Hydrin), include ursodeox... more
This case report describes the occurrence of adverse effects after application of topical neuromodulators for the treatment of pruritus.
Facial Redness & Gout & Pruritus Symptom Checker: Possible causes include Polycythemia Vera. Check the full list of possible causes and conditions now! Talk to our Chatbot to narrow down your search.
Finally I Found This Name For This!!!! : A true, personal story from the experience, I Have Aquagenic Pruritus. I am 34 years old, living in Florida my whole life and have experienced brutally itchy legs after showers for years. I have mentioned it to dermatologists and even a neurologist time after time with n...
List of 60 causes for Abdomen blister and Pruritus in children and Rash in children, alternative diagnoses, rare causes, misdiagnoses, patient stories, and much more.
List of 34 causes for Neck rash and Pruritus ani, alternative diagnoses, rare causes, misdiagnoses, patient stories, and much more.
BOONTON, N.J., June 27, 2019 /PRNewswire/ -- Enteris BioPharma, Inc., a biotechnology company developing innovative drug products built around its proprietary delivery technologies, congratulates Cara Therapeutics (Nasdaq: CARA) on the successful initiation of its Phase 2 clinical trial of Oral KORSUVA™ (CR845/difelikefalin) for the treatment of pruritus in patients with hepatic impairment due to primary biliary cholangitis (PBC). The tablet formulation of Oral KORSUVA was engineered using Enteris proprietary oral peptide delivery technology, Peptelligence®. The Oral KORSUVA Phase 2 initiation in pruritis associated with PBC follows a Phase 1 trial in patients with hepatic impairment, which successfully established the Oral KORSUVA tablet strength. Building upon that study, the Phase 2 trial is a multicenter, randomized, double-blind, placebo-controlled 16-week trial designed to evaluate the safety and efficacy of 1 mg tablet of Oral KORSUVA taken twice daily (BID) versus placebo in ...
Congestion, sneezing, rhinorrhea, and pruritus symptom scores for controls and patients with NARES, before and after NSNPT with histamine. Data are presented as
Looking for a cure for fatty liver?: Pruritus Related To Fatty Liver. The Fatty Liver Site, Tips and natural treatments for fatty liver.
Pruritus ani means a persistent itchy feeling around the anus. Its a common condition in both adults and children. In fact, 1 in 20 people will develop it at s
Something New To Try : A true, personal story from the experience, I Have Aquagenic Pruritus. I have had AP for about 13 years, exactly as other sufferers have described, and have spent that time looking for solutions. I think I may have found something to help at least some of my fellow-suffe...
Vulvar pruritus and hypothyroidism - What diet should someone with hypothyroid follow? Avoid what foods? Iodine good. Foods from the sea have iodine good. Ones that bind up iodine bad (these are all the healthy broccoli family foods like broccoli, kale, cabbage). Just have more good than bad and dont do silly amounts of either
Itchy Bottom (Pruritus Ani) According to the world health authority the annual occurrence of typhoid fever is estimated at 17 million cases, with approximately 600,000 deaths ...
Itchy Bottom (Pruritus Ani) This is a common problem and refers to itching around the anus. The skin in this area is sensitive and is regularly exposed to irritating digestive products in the stool ...
Corić-Martinović V, Basić-Jukić N (2008). "[Uremic pruritus]". Acta Medica Croatica. 62 Suppl 1: 32-6. PMID 18578330. Carpenter ... Uremic pruritus Vision changes Vomiting Hypervitaminosis A results from excessive intake of preformed vitamin A. Genetic ...
Pruritus Itching skin; may be a symptom of diabetes. Purified insulins Insulins with much less of the impure proinsulin. It is ...
Pruritus James, William; Berger, Timothy; Elston, Dirk (2005). Andrews' Diseases of the Skin: Clinical Dermatology. (10th ed ...
Ajayi AA (September 2000). "Mechanisms of chloroquine-induced pruritus". Clinical Pharmacology and Therapeutics. 68 (3): 336. ...
The most characteristic symptom of infestation is pruritus (itching) on the head which normally intensifies 3 to 4 weeks after ... ISBN 978-953-51-2252-4. Leung AK, Robson LM (May 1, 2008). "Pruritus in Children: What's Itching?". Consultant for ...
Psorergates bovis causes pruritus, but little clinical harm to cattle. In contrast, Psorergates ovis feeding on sheep induces ... Stress caused by the pruritus can be severe, and will result in 6% to 23% lost productivity of commercially reared pigs. Camels ... Larvae of trombiculids cause severe pruritus to their hosts after they detach. The larva secretes a proteinaceous feeding tube ... The feeding of the mites and their excretory products irritates and inflames the skin, causing intense pruritus. Dermal ...
A classic symptom of polycythemia vera is pruritus or itching, particularly after exposure to warm water (such as when taking a ... Common signs and symptoms include itching (pruritus), and severe burning pain in the hands or feet that is usually accompanied ... Fjellner B, Hägermark O (1979). "Pruritus in polycythemia vera: treatment with aspirin and possibility of platelet involvement ... "Polycythemia vera-associated pruritus and its management". Eur J Clin Invest. 40 (9): 828-34. doi:10.1111/j.1365-2362.2010. ...
Systemic pruritus has been linked to cholestasis, thyroid disease, polycythaemia rubra vera, uraemia, Hodgkins disease, HIV and ... Pruritus Skin lesion Lockshin BN, Brogan B, Billings S, Billings S (2006). "Eczematous dermatitis and prurigo nodularis ... 2006). "IL-31: a new link between T cells and pruritus in atopic skin inflammation". J. Allergy Clin. Immunol. 117 (2): 411-7. ... have a history of chronic severe pruritus. have a significant medical history for unrelated conditions. suffer from liver or ...
Lebovics, E; Seif, F; Kim, D; Elhosseiny, A; Dworkin, BM; Casellas, A; Clark, S; Rosenthal, WS (May 1997). "Pruritus in chronic ... Bergasa, NV; Thomas, DA; Vergalla, J; Turner, ML; Jones, EA (1993). "Plasma from patients with the pruritus of cholestasis ... Jones, EA; Bergasa, NV (Dec 16, 1992). "The pruritus of cholestasis and the opioid system". JAMA. 268 (23): 3359-62. doi: ... and treatment refractory pruritus". Hepatology Research. 25 (4): 442-446. doi:10.1016/s1386-6346(02)00310-8. PMID 12699855. ...
Both the migrating females and the clumps of eggs are irritating, but the mechanisms causing the intense pruritus have not been ... Stermer, E; Sukhotnic, I; Shaoul, R (May 2009). "Pruritus ani: an approach to an itching condition". Journal of Pediatric ...
Pruritus, gout, and mucocutaneous bleeding are occasionally seen. The cause of CNL is currently unknown. An association between ...
Pruritus List of cutaneous conditions Erythroderma James, William; Berger, Timothy; Elston, Dirk (2005). Andrews' Diseases of ...
Regan AM, Metersky ML, Craven DE (December 1987). "Nosocomial dermatitis and pruritus caused by pigeon mite infestation". ... Dogramaci AC, Culha G, Ozçelik S (September 2010). "Dermanyssus gallinae infestation: an unusual cause of scalp pruritus ...
The drug patch is placed on the skin, and if the patient is infected with O. volvulus microfilaria, localized pruritus and ... The severe pruritus alone accounts for 60% of the DALYs. Infection reduces the host's immunity and resistance to other diseases ... pruritus and common secondary bacterial infections Skin atrophy - loss of elasticity, the skin resembles tissue paper, 'lizard ...
Injection site erythema, peripheral edema, injection site pruritus and diarrhea. List of growth hormone secretagogues "Egrifta ...
Medicine portal Anal fistula Hemorrhoid Pruritus ani Gott, M. D.; Peter, H. (5 March 1998). "New Therapy Coming for Anal ...
It has also completed a phase III clinical trial for uremic pruritus in hemodialysis patients. Difelikefalin acts as an ... In addition to use as an analgesic, difelikefalin is also being investigated for the treatment of pruritus (itching). ... "A phase 3 trial of difelikefalin in hemodialysis patients with pruritus". N Engl J Med. 382 (3): 222-232. doi:10.1056/ ...
The fruits are useful in jaundice, ulcers, pruritus and skin diseases. Hepatoprotective Activity of Extracts from Stem of ...
... but he also described pruritus hiemalis ("winter itch"), and seborrheic dermatitis. After a stint with the 32nd Regiment of ...
Some patients do, however, report vulvar pain, pruritus, dyspareunia or dysuria. Upon examination, at least one of 4 types of ...
Mosquitos Lice infestations (pediculosis) cause intense pruritus, scratching, and hair loss. The two species of chewing lice ...
Vasodilation coupled with histamine release can result in pruritus, sweating and flushing. Hydrocodone, like other opioids, ... pruritus (11.5%), dizziness (7.5%) and headache (6.0%). Benzhydrocodone/APAP use with serotonergic drugs can cause serotonin ...
The reaction is also common with red ink, which may contain cinnabar (mercuric sulphide). Erythema, pruritus, and even inflamed ...
... is known to cause photosensitivity reactions, rash, pruritus and dry skin. Patients are usually advised to avoid ...
Kaushik A, Pinto HP, Bhat RM, Sukumar D, Srinath MK (2014). "A study of the prevalence and precipitating factors of pruritus in ...
... ecchymoses and pruritus. There has also been a case report of pubic bone edema associated with vigorous usage. In general, all ...
The lesion may be asymptomatic or accompanied by mild pruritus, pain, and fever. Erysipelothrix rhusiopathiae may infect a wide ...
A few minutes of exposure to the sun induces pruritus, erythema, swelling and pain. Longer periods of exposure may induce ...
It is being investigated by Vanda Pharmaceuticals for chronic pruritus (itchiness) in atopic dermatitis. In March 2015, Vanda ... "Vanda Pharmaceuticals Announces Tradipitant Phase II Proof of Concept Study Results for Chronic Pruritus in Atopic Dermatitis ...
Corticosteroids (e.g. prednisone) are used only if pruritus is a major clinical feature. Commonly used dietary supplements ...
Itching (pruritus) is a common symptom associated with numerous skin diseases, as well as a secondary symptom of numerous ... 2006. Frontiers in pruritus research: scratching the brain for more effective itch therapy. Journal of Clinical Investigation ... Following evening cannabinoid administration, all three patients reported a decrease in pruritus, as well as "marked ... More recently, Polish researchers reported that application of an endocannabinoid-based topical cream reduced uremic pruritus ...
Treatment of Pruritus in Dogs. The key to relief from pruritus is to identify and treat the underlying cause. Pruritus may be ... How pruritus affects your dogs health depends on the degree of the pruritus. Mild pruritus may hardly have any effect at all. ... Diagnosis of Pruritus in Dogs. Diagnostic tests may be needed to determine the cause of the pruritus. Your veterinarian will ... Many skin diseases can cause or can contribute to pruritus. Every dog has a threshold of pruritus. When the nerves of the skin ...
Purchase Pruritus, An Issue of Dermatologic Clinics, Volume 36-3 - 1st Edition. Print Book & E-Book. ISBN 9780323610803, ... Pruritus in Scabies; Pruritus Associated with Targeted Cancer Therapies and Their Management; Pruritus in Lymphoma and its ... Pruritus in Connective Tissue Disorders; Immunomodulating Agents as Anti Pruritics; Psychogenic Pruritus and its Management; ... Gil Yosipovitch, is devoted to Pruritus (Itch). Articles in this issue include: Pathophysiology of Chronic Itch; Work-up of ...
Ask questions and get answers about Pruritus of Partial Biliary Obstruction. Our support group helps people share their own ... Home › Q & A › Support Groups › Pruritus of Partial Biliary Obstruction. Join the Pruritus of Partial Biliary Obstruction ... Pruritus of Partial Biliary Obstruction - What other things can I do to stop the pruritus?. Posted 26 Sep 2009 • 1 answer ... Pruritus. Related Drug Support Groups. cholestyramine, Questran, Prevalite, Cholestyramine Light, Questran Light, Locholest, ...
In contrast to conditions, such as urticaria, in which histamine primarily drives itch (pruritus), cholestatic pruritus is ... In contrast to conditions, such as urticaria, in which histamine primarily drives itch (pruritus), cholestatic pruritus is ... Cholestatic pruritus: Emerging mechanisms and therapeutics J Am Acad Dermatol. 2019 Dec;81(6):1371-1378. doi: 10.1016/j.jaad. ... Although these new therapies show promise, further research is needed to confirm the pathophysiology of cholestatic pruritus so ...
... uremic pruritus, multiple sclerosis-induced pruritus,cholestatic pruritus, itch produced by burn, and pruritus of unknown ... Incidence of pruritus was measured by using Chi-Square test. The onset time and severity of pruritus was analyzed by means of ... incidence of pruritus postoperatively [ Time Frame: 0-24 h ]. the incidence of pruritus during the 24 h follow-up period ... onset time and severity of pruritus [ Time Frame: 0-24 h ]. The difference of onset time and severity of pruritus in the ...
Patients describe intense pruritus and often have eosinophilia.. Bullous pemphigoid is most common in women and older adults. ...
What is pruritus? Meaning of pruritus as a legal term. What does pruritus mean in law? ... Definition of pruritus in the Legal Dictionary - by Free online English dictionary and encyclopedia. ... Kasinti ya da pruritus kasima arzusu yaratan nahos bir duyum olarak tanimlanir.. Psychogenic pruritus/Psikojenik pruritus ... redirected from pruritus). Also found in: Dictionary, Thesaurus, Medical, Encyclopedia, Wikipedia.. Related to pruritus: ...
Pruritus, or itchy skin, is one of the most common skin complaints of older adults. The itching itself may be related to ... Pruritus, or itchy skin, is one of the most common skin complaints of older adults. The itching itself may be related to ...
Pruritus is a chronic itching condition caused due to dermatological disease including atopic dermatitis, contact dermatitis, ... The report segments the pruritus therapeutics market on the basis of type, disease type and geography. ... Pruritus Therapeutics Market: Segmentation. The report segments the pruritus therapeutics market on the basis of type, disease ... Pruritus Therapeutics Market: Competitive Players. The key players of the pruritus therapeutics market include Pfizer, Tai Guk ...
... provides an overview of the Pruritus (Dermatology) pipeline landscape. Pruritus, or itch, is defined as an unpleasant ... Pruritus, or itch, is defined as an unpleasant sensation that provokes the desire to scratch. Pruritus is caused by cancer, ... The Pruritus (Dermatology) pipeline guide also reviews of key players involved in therapeutic development for Pruritus and ... Pruritus - Pipeline Review, H1 2017, provides an overview of the Pruritus (Dermatology) pipeline landscape. ...
Pruritus is common and associated with QOL in SSc. More attention to pruritus in SSc is needed, including its measurement, ... Pruritus, QOL, and disability.. As shown in Table 1, pruritus was negatively associated, indicating worse function, with the ... Depression modulates pruritus perception: a study of pruritus in psoriasis, atopic dermatitis and chronic idiopathic urticaria ... A total of 248 patients (43%) reported pruritus on most days. Patients with pruritus had significantly worse mental (Hedgess g ...
... a biopharmaceutical company focused on developing and commercializing new chemical entities designed to alleviate pruritus by ... as a treatment for pruritus in patients with hepatic impairment due to PBC or moderate-to-severe pruritus in stage III-V CKD ... for the treatment of pruritus in patients with hepatic impairment due to primary biliary cholangitis (PBC). Pruritus is a ... About Pruritus Associated with Primary Biliary Cholangitis. PBC is a rare, chronic, immune-mediated progressive liver disorder ...
Pruritus is usually an unpleasant sensation that elicits a desire to scratch, subjectively quantified by intensity, severity, ... For pruritus of cholestasis.. [36][Level of evidence: IV]. Cholestyramine. 4-16 g daily. For pruritus of cholestasis.. [36][ ... Table 1. Pruritus Differential With Little or No Primary Dermatitis. Disease State. Prevalence of Pruritus (%). ... Pruritus is a symptom, not a diagnosis or disease. Generalized pruritus should be investigated because of its strong medical ...
... and correct diagnosis for Brachioradial pruritus signs or Brachioradial pruritus symptoms. ... Symptoms of Brachioradial pruritus including 9 medical symptoms and signs of Brachioradial pruritus, alternative diagnoses, ... Research More About Brachioradial pruritus. Do I have Brachioradial pruritus? *Brachioradial pruritus: Introduction * ... Treatments for Brachioradial pruritus *More about Brachioradial pruritus Brachioradial pruritus: Undiagnosed Conditions. ...
Pruritus scroti is itchiness of the scrotum that may be secondary to an infectious cause. Pruritus vulvae Pruritus ani Pruritus ...
Psychogenic pruritus is a common manifestation of chronic anxiety, usually a localized itch, especially in the anogenital area ...
Uremic pruritus (also known as uraemic pruritus or renal pruritus[1]) is caused by chronic kidney failure and is the most ... Inui, Shigeki (2015). "Nalfurafine hydrochloride to treat pruritus: a review". Clinical, Cosmetic and Investigational ... Retrieved from "https://en.wikipedia.org/w/index.php?title=Uremic_pruritus&oldid=839888746" ...
... that can show pruritus ani as first symptom. [9] Pruritus scroti Pruritus vulvae Perianal candidiasis James, William; Berger, ... If a specific cause for pruritus ani is found it is classified as "secondary pruritus ani". If a specific cause is NOT found it ... For pruritus ani of unknown cause (idiopathic pruritus ani) treatment typically begins with measures to reduce irritation and ... Pruritus ani is the irritation of the skin at the exit of the rectum, known as the anus, causing the desire to scratch. The ...
Vulval Pruritus. Br Med J 1969; 1 doi: https://doi.org/10.1136/bmj.1.5638.255-c (Published 25 January 1969) Cite this as: Br ...
This book provides a thorough and comprehensive reference in the management of pruritus, designed to be a convenient resource ... Pruritus, Second edition addresses the new concepts and discoveries that have modified our understanding of this condition. It ... Acute and chronic pruritus can represent significant management issues both as a common physiological sensation and as a ... The consequences are that research on this field has been poorer than research on pain and that pruritus is therefore more ...
Brachioradial pruritus is a neurogenic itch syndrome of the upper extremities. It is typically localized to the skin on the ... Waisman M. Solar pruritus of the elbows (brachioradial summer pruritus). Arch Dermatol. 1968 Nov. 98(5):481-5. [Medline]. ... Brachioradial pruritus wanted: a sure cause (and cure) for brachioradial pruritus. Int J Dermatol. 1997 Nov. 36(11):817-8. [ ... Area of pruritus demarcated in pen in a middle-aged woman with brachioradial pruritus. Macroscopically, no skin changes are ...
Broadly, pruritus can be due to a primary dermatological disorder or to an underlying system disease. A wide... ... The impact of pruritus on quality of life: the skin equivalent of pain. Arch Dermatol. 2011;147(10):1153-6.CrossRefPubMedGoogle ... Willans itch and other causes of pruritus in the elderly. Int J Dermatol. 2005;44(4):267-273.CrossRefPubMedGoogle Scholar ... Pruritus of unknown origin: a retrospective study. J Am Acad Dermatol. 2002;45: 892-6.CrossRefGoogle Scholar ...
Article: Effectiveness and safety of different medicines for Uremia pruritus: A protocol... ... Article: Effectiveness of montelukast for uremic pruritus in hemodialysis patients: A protocol... ...
Correction: Aquagenic pruritus Br Med J (Clin Res Ed) 1981; 283 :505 ... Correction: Aquagenic pruritus. Br Med J (Clin Res Ed) 1981; 283 doi: https://doi.org/10.1136/bmj.283.6289.505-b (Published 15 ...
Treatment measures for pruritus include the following{ref164}: Moisturizers Histamine 1 (H1) and histamine 2 (H2) blockers ... encoded search term (How is pruritus treated in scleroderma?) and How is pruritus treated in scleroderma? What to Read Next on ... How is pruritus treated in scleroderma?. Updated: Nov 13, 2018 * Author: Sergio A Jimenez, MD, MACR, FACP, FRCP(UK Hon); Chief ...
... itch or pruritus). Get relief with home remedies for itchy skin. Dry skin, fungus, sunburn, and bites may cause itching. ... Itch (Itching or Pruritus). Facts Symptoms/Signs Causes Diagnosis Specialists Should You Scratch? Treatment Remedies ... Pruritus can be caused by many conditions. Stress, anxiety, or other emotional problems can cause itching. Stress also can ... Itch (Itching or Pruritus) Browse through our medical image collection to see pictures of the most common, and uncommon, skin ...
... itch or pruritus). Get relief with home remedies for itchy skin. Dry skin, fungus, sunburn, and bites may cause itching. ... Pruritus can be caused by many conditions. Stress, anxiety, or other emotional problems can cause itching. Stress also can ... Itch (Itching or Pruritus) Browse through our medical image collection to see pictures of the most common, and uncommon, skin ... When pruritus is caused by irritations of other sorts (insect bites, for instance), hydrocortisone doesnt help much at all. If ...
Pruritus) zu erleichtern, ist eine schwierige Aufgabe der pädiatrischen Dermatologie, ist es doch das Hauptsymptom der ... Chronic pruritus in atopic dermatitis. Abstract. To relieve the sensation of itch (pruritus) is one of the most difficult tasks ... Pruritus Gehirn-Haut-Interaktion Pruritus und seine Weiterleitung Einflussmöglichkeiten und Hindernisse Atopische Dermatitis ... Szepietowski JC, Reich A, Wisnicka B (2004) Pruritus and psoriasis. Br J Dermatol 151(6):1284CrossRefPubMedGoogle Scholar ...
Whether these mechanisms are involved in pruritus accompanying LP requires further investigation. Limited knowledge of pruritus ... T. Liu, Z.-Z. Xu, C.-K. Park, T. Berta, and R.-R. Ji, "Toll-like receptor 7 mediates pruritus," Nature Neuroscience, vol. 13, ... It was supposed that activation of μ-opioid receptors induces pruritus, while activation of -opioid receptors exerts an ... H. L. Tey and G. Yosipovitch, "Targeted treatment of pruritus: a look into the future," British Journal of Dermatology, vol. ...
Epidemiologic Notes and Reports Mucuna pruriens- Associated Pruritus -- New Jersey On October 6, 1985, a Paterson, New Jersey, ... Soon after their arrival, the EMTs developed pruritus. All four individuals went to an emergency room complaining of itching ... Fire Department ambulance responded to a call reporting two people with severe pruritus. On arrival, the two emergency medical ...
... , Perianal Pruritus, Anal Pruritus, Perianal Dermatitis. ... Pruritus ani, Anal itch, Perianal itch, Pruritus ani (disorder), itch; anal, pruritus; ani, anal; itch, ani; pruritus, Pruritus ... PRURITUS ANI, pruritus ani (diagnosis), anal itching, pruritus ani, anal itching (symptom), rectal pruritus, anal pruritus, ... pruritus aan bilnaad, pruritus ani, perianale jeuk, anale pruritus, perianale irritatie, anaal; jeuk, ani; pruritus, jeuk; ...
... "mild pruritus," "moderate pruritus," "severe pruritus," and "very severe pruritus." All pregnant women with pruritus were asked ... The point prevalence of pruritus was 20.2% (. ), while pruritus prevalence during the entire pregnancy was 38.0% (. ). Pruritus ... Characteristic of Pruritus. Pruritus on average started at WoG. In most pregnant women, it started after the 25th WoG, although ... Pruritus Severity and Quality of Life Impairment. The mean intensity of pruritus measured with VAS was points ranging from 0.6 ...
... itch or pruritus). Get relief with home remedies for itchy skin. Dry skin, fungus, sunburn, and bites may cause itching. ... Pruritus can be caused by many conditions. Stress, anxiety, or other emotional problems can cause itching. Stress also can ... When pruritus is caused by irritations of other sorts (insect bites, for instance), hydrocortisone doesnt help much at all. If ... Brachioradial pruritus is a neurologic condition that results in intense itching of the arms. It usually develops on the ...
Pruitus ani (anal itching) is a skin condition around the anus that can affect both men and women at any age. Factors such as faeces or mucus from the anus irritate the surrounding skin, which causes itching. Scratching can further damage the skin.
The condition, aquagenic pruritus, causes a severe itching sensation immediately after water of any temperature touches the ... Aquagenic pruritus may make daily hygiene a challenge, but the right medication and clothing choices can minimise allergic ... The condition, aquagenic pruritus, causes a severe itching sensation immediately after water of any temperature touches the ... Ask your doctor for recommendations on how to treat your aquagenic pruritus. A doctors assessment is important, because the ...
Helping you find trustworthy answers on Pruritus in Pregnancy , Latest evidence made easy ... Find all the evidence you need on Pruritus in Pregnancy via the Trip Database. ... The pruritus persists and worsens as the pregnancy continues and resolves within 48 hours of delivery. The pruritus is often ... pruritus and raised levels of serum bile acids) or pruritus and raised alanine transaminase levels (>100 IU/L) recruited after ...
Prevalence and characterization of uremic pruritus in patients undergoing hemodialysis: uremic pruritus is still a major ... ABSTRACT: Uremic pruritus (UP) is a common complication in patients with chronic kidney disease. Although the etiology of UP is ... Uremic Pruritus Review. Muideen Adigun, PharmD, BCPS, BCPP. Program Director, PGY-1 Pharmacy Practice Residency. Howard ... of patients with severe pruritus at baseline experienced reduction of symptoms to weak pruritus and 40% experienced reduction ...
The term scleroderma is derived from the Greek words skleros (hard or indurated) and derma (skin) and it is used to describe a disease characterized by progressive skin hardening and induration. Hippocrates first described this condition as thickened skin.
... pruritus) - Comprehensive overview of this common irritating skin condition covers causes, treatment and self-care measures. ... Chronic pruritus in the absence of specific skin disease. American Journal of Clinical Dermatology. 2010;11:399. ... Pathophysiology and clinical aspects of pruritus. In: Fitzpatricks Dermatology in General Medicine. 8th ed. New York, N.Y.: ... Some people with long-term pruritus say that a hot shower eases their symptoms for hours. Others say a cold shower helps. ...
Pruritus can be a consequence of tumour growth, a complication of treatment, secondary to cholestasis, or caused by brain ... The first two complications are discussed in detail, as are how to recognize patterns and treat pruritus caused by cancer. ... Paroxetine is considered to be the drug of choice for symptomatic treatment of pruritus-complicating cancer. ... This chapter discusses pruritus that accompanies solid tumours. This is considered to be an uncommon symptom, but it can ...
78 patients with brachioradial pruritus experience pain, burning sensation, depressed mood, fatigue, and itching and use ... Find the most comprehensive real-world symptom and treatment data on brachioradial pruritus at PatientsLikeMe. ... Acupuncture, Bupropion, Gabapentin, Ice or Cold Packs, and Naltrexone to treat their brachioradial pruritus and its symptoms. ... What is brachioradial pruritus?. Brachioradial pruritus is considered a neurogenic itch syndrome of the upper extremities. It ...
There are several common causes of pruritus vulvae... ... Pruritus vulvae is a persistent, uncomfortable itch on and ... Pruritus vulvae may be a sign of a sexually transmitted disease. Painful urination may occur as a result of pruritus vulvae. ... Scented feminine hygiene products are a common cause of pruritus vulvae. To help prevent or treat pruritus vulvae, women should ... A gynecologist can advise on pruritus vulvae. Relatively mild instances of pruritus vulvae tend to respond well to home ...
  • More recently, Polish researchers reported that application of an endocannabinoid-based topical cream reduced uremic pruritus and xerosis (abnormal dryness of the skin) in hemodialysis patients. (norml.org)
  • 2005. Efficacy and tolerance of the cream containing structured physiological lipid endocannabinoids in the treatment of uremic pruritus: a preliminary study . (norml.org)
  • Many studies have shown gabapentin to be effective in the case of brachioradial pruritus, itch of neuropathic in origin, uremic pruritus, multiple sclerosis-induced pruritus,cholestatic pruritus, itch produced by burn, and pruritus of unknown origin. (clinicaltrials.gov)
  • Complete our nephrology jumble-bumble to test your knowledge on uremic pruritus! (ajkdblog.org)
  • Can the Aggravation of Pruritus be a Sign of Worsening Peripheral Neuropathy in Uremic Disease? (ommegaonline.org)
  • Another symptom related to uremic disease is pruritus, which may be diffuse all over the body, but usually occurring in the lower limbs. (ommegaonline.org)
  • We noted that a severe intensity of pruritus can be related to severity of neuropathy in uremic subjects and may become predictive of progressing neuropathy. (ommegaonline.org)
  • In this study we examined a group of uremic subjects, clinically and with neurophysiological investigations, discovering a remarkable association between the intensity of pruritus and the severity of neuropathy. (ommegaonline.org)
  • Peripheral neuropathy represents a frequent complication of uremic disease, with a prevalence of 60 - 80 % of cases [1] , while pruritus is a symptom considered present in 30 - 60 % of uremic patients [2] . (ommegaonline.org)
  • In this study, we have observed 12 uremic patients who had been admitted to our Unit to determine whether or not their pruritus was a clinical sign of a uremic neuropathy. (ommegaonline.org)
  • Therefore, we hypothesized that pruritus can be a marker of progression of uremic neuropathy. (ommegaonline.org)
  • Brachioradial pruritus is a condition in which the skin of one or both arms, specifically often the mid-arm, experiences severe itching. (ozarkderm.com)
  • Brachioradial pruritus is generally attributed to various forms of nerve damage, usually cervical in nature (including osteoarthritis, spinal tumors, and nerve compression). (ozarkderm.com)
  • The main goal in treating Brachioradial pruritus is two-fold: alleviating symptoms and treating the causative condition. (ozarkderm.com)
  • Pruritus is a feature of the following less familiar conditions: lichen simplex chronicus, prurigo nodularis, Grover's disease, brachioradial pruritus, notalgia paraesthetica and urticarial dermatosis. (medicinetoday.com.au)
  • But when you have brachioradial pruritus, the intensely itchy skin looks completely normal before you start scratching. (drbaileyskincare.com)
  • My right arm has the itch of brachioradial pruritus so I get to "observe" the condition daily. (drbaileyskincare.com)
  • There are other conditions where it's possible to have total body itching with no visible rash on the skin, but in brachioradial pruritus the itching is limited mainly to the arms. (drbaileyskincare.com)
  • How Do You Know if You Might Have Brachioradial Pruritus? (drbaileyskincare.com)
  • Brachioradial pruritus usually begins in adulthood, especially if the skin on your arms is sun damaged. (drbaileyskincare.com)
  • We've suspected nerve impingement to be the cause of both brachioradial pruritus and notalgia paresthetica, but now it's conclusive! (drbaileyskincare.com)
  • There also seems to be a role for sun damage in brachioradial pruritus. (drbaileyskincare.com)
  • It is estimated that pruritus is a manifestation of an underlying systemic disease in approximately 10% to 25% of affected individuals. (peacehealth.org)
  • Mirtazapine may be a useful systemic agent for the palliative relief of pruritus associated with cutaneous infiltration by an underlying malignancy. (bmj.com)
  • This chapter presents an overview of different forms of common systemic pruritus and their diagnostic measures and treatment options. (elsevier.com)
  • pruritus without a rash suggests a systemic cause for the itch. (medicinetoday.com.au)
  • If a systemic cause for pruritus is suspected, limited investigations are warranted. (medicinetoday.com.au)
  • do you have weight loss , loss of appetite, any other symptoms associated apart from the generalized pruritus? (healthcaremagic.com)
  • Here is a rundown of causes, symptoms and prevention of pruritus. (drscabies.com)
  • What Are the Symptoms and Risk Factors of Pruritus? (healthtopquestions.com)
  • All patients were under three days weekly hemodialytic treatment and referred clinical symptoms, evoking the presence of peripheral motor and sensory neuropathy: weakness of the legs, pain and paresthesias of lower limbs, associated with pruritus. (ommegaonline.org)
  • Writing in the August 2002 issue of the American Journal of Gastroentrology , investigators from the University of Miami Department of Medicine reported successful treatment of pruritus with 5 mg of THC in three patients with cholestatic liver disease. (norml.org)
  • Delta-9-tetrahydrocannabinol may be an effective alternative in patients with intractable cholestatic pruritus," investigators concluded. (norml.org)
  • 2002. Preliminary observation with dronabinol in patients with intractable pruritus secondary to cholestatic liver disease . (norml.org)
  • In contrast to conditions, such as urticaria, in which histamine primarily drives itch (pruritus), cholestatic pruritus is multifactorial and more difficult to treat. (nih.gov)
  • Here, we conducted a systematic literature review to evaluate conventional treatment strategy, current pathophysiologic understanding, and the role of new therapies in the context of cholestatic pruritus. (nih.gov)
  • Although these new therapies show promise, further research is needed to confirm the pathophysiology of cholestatic pruritus so that targeted therapy can be developed. (nih.gov)
  • Pruritus is a common symptom of cholestatic liver diseases with a prevalence of up to 70 percent in patients with PBC. (yahoo.com)
  • Pruritus continues to be a significant comorbidity in patients with chronic cholestatic liver diseases and may be exacerbated by certain bile acid-related drugs," said Derek Chalmers, Ph.D., D.Sc. (yahoo.com)
  • The clinical and pathological findings were consistent with a diagnosis of carcinoma en cuirasse . (bmj.com)
  • Here is a practical approach to the diagnosis of its causes and its management, including a discussion of some less familiar conditions in which pruritus is a feature. (medicinetoday.com.au)
  • Objective: We sought to assess the hazard ratio (HR) of incident overall malignancy and incident malignancy by subtype in patients with chronic pruritus during the 5 years after diagnosis. (elsevier.com)
  • Pruritus - Pipeline Review, H1 2017, provides an overview of the Pruritus (Dermatology) pipeline landscape. (medgadget.com)
  • Global Markets Direct's Pharmaceutical and Healthcare latest pipeline guide Pruritus - Pipeline Review, H1 2017, provides comprehensive information on the therapeutics under development for Pruritus (Dermatology), complete with analysis by stage of development, drug target, mechanism of action (MoA), route of administration (RoA) and molecule type. (medgadget.com)
  • The Pruritus (Dermatology) pipeline guide also reviews of key players involved in therapeutic development for Pruritus and features dormant and discontinued projects. (medgadget.com)
  • Pruritus (Dermatology) pipeline guide helps in identifying and tracking emerging players in the market and their portfolios, enhances decision making capabilities and helps to create effective counter strategies to gain competitive advantage. (medgadget.com)
  • The pipeline guide provides a snapshot of the global therapeutic landscape of Pruritus (Dermatology). (medgadget.com)
  • The pipeline guide reviews pipeline therapeutics for Pruritus (Dermatology) by companies and universities/research institutes based on information derived from company and industry-specific sources. (medgadget.com)
  • The pipeline guide reviews key companies involved in Pruritus (Dermatology) therapeutics and enlists all their major and minor projects. (medgadget.com)
  • The pipeline guide evaluates Pruritus (Dermatology) therapeutics based on mechanism of action (MoA), drug target, route of administration (RoA) and molecule type. (medgadget.com)
  • Find and recognize significant and varied types of therapeutics under development for Pruritus (Dermatology). (medgadget.com)
  • Formulate corrective measures for pipeline projects by understanding Pruritus (Dermatology) pipeline depth and focus of Indication therapeutics. (medgadget.com)
  • Prevalence of pruritus in patients with chronic liver disease: A multicenter study. (yahoo.com)
  • The study provides a decisive view on the pruritus therapeutics market by segmenting the market based on therapeutic type and regions. (medgadget.com)
  • Pruritus has been commonly reported with varying severity in patients with PBC and contributes to a large symptomatic burden, including reduced quality of life. (yahoo.com)
  • Pruritus is usually an unpleasant sensation that elicits a desire to scratch, subjectively quantified by intensity, severity, location, and intractability. (peacehealth.org)
  • Sex, age, years in hemodialysis, severity of neuropathy and pruritus intensity of the patients under study. (ommegaonline.org)
  • The severity of pruritus and the extent and severity of erythema were quantified in 107 dogs presenting with various dermatoses. (edu.au)
  • Pruritus was assessed using a previously validated scale, and erythema was quantified by assessing severity at 72 different body sites. (edu.au)
  • Pruritus is the most common side effect of intrathecal morphine, which the incidence was reported as 20%-100%2 and 63% in Songklanagarind Hospital. (clinicaltrials.gov)
  • However, there is only one small study in Taiwan shown the effectiveness of gabapentin 1200 mg in prevention of intrathecal morphine-induced pruritus in orthopedic surgery, which could reduce incidence of pruritus from 77.5% to 47.5% (38.7% reduction). (clinicaltrials.gov)
  • Therefore, we would like to know if gabapentin in a smaller dose (600 mg) used in the wider range of age including the elderly can decrease the incidence of intrathecal morphine-induced pruritus in orthopedic surgery in Songklanagarind Hospital. (clinicaltrials.gov)
  • Where available, the incidence of pruritus in that condition is given. (peacehealth.org)
  • Background: The incidence of malignancy in patients with chronic pruritus and nondiseased skin is unknown. (elsevier.com)
  • The incidence of hematologic malignancy and cholangiocarcinoma in patients with chronic pruritus was 0.0016 and 0.0003 per person-year, respectively. (elsevier.com)
  • The overall incidence of these malignancies in patients with chronic pruritus is very low. (elsevier.com)
  • These individuals are often referred to as having "pruritus with no rash. (edu.au)
  • What does "pruritus with no rash" look like? (edu.au)
  • The changes seen on the skin in "pruritus with no rash" are due to scratching and rubbing. (edu.au)
  • The U.S. Food and Drug Administration (FDA) has granted Breakthrough Therapy designation to I.V. CR845 for the treatment of moderate-to-severe pruritus in CKD patients undergoing hemodialysis. (yahoo.com)
  • Itching ( pruritus ) is a common symptom associated with numerous skin diseases, as well as a secondary symptom of numerous serious conditions such as renal failure and liver disease. (norml.org)
  • Any skin condition that causes inflammation can cause pruritus. (petplace.com)
  • However, severe pruritus leads to intense scratching, which may result in painful skin lesions that may become infected. (petplace.com)
  • Pruritus is associated with other skin diseases, including secondary bacterial skin infections (pyoderma) and secondary yeast infections. (petplace.com)
  • Many skin diseases can cause or can contribute to pruritus. (petplace.com)
  • It is common to see dogs with two or more skin conditions that cause pruritus concurrently. (petplace.com)
  • Pruritus is caused by cancer, cancer treatments, infection, dry skin and reaction to a drug. (medgadget.com)
  • Pruritus or itching is defined as skin condition being marked with itching and dryness. (drscabies.com)
  • Pruritus is an extremely dry skin characterized by severe itching. (drscabies.com)
  • Dry skin is a key cause of pruritus and is likely to be occurred from the hot/cold weather, prolonged sitting in AC or in heating, taking excessive washing and bathing. (drscabies.com)
  • Attention to general skin care principles is essential for patients with pruritus. (medicinetoday.com.au)
  • Some people will have pruritus without a skin disorder. (edu.au)
  • Avoid all environmental aggravators of pruritus such as overheating, drying of the skin and prickly/rough materials in contact with the skin. (edu.au)
  • We noted that the patients affected by more severe neuropathy, complained of a greater intensity of pruritus, associated with marked skin lesions due to severe scratching. (ommegaonline.org)
  • Particularly, 5 of these patients reported a progressive worsening ofintensity of pruritus, associated to serious skin alterations like dyscromias and redness, until severe excoriations, mainly at the lower limbs. (ommegaonline.org)
  • Conclusions: Chronic pruritus without concomitant skin changes is a risk factor for having undiagnosed hematologic and bile duct malignancies, but not other malignancies. (elsevier.com)
  • [6] Three weeks of twice-daily application of the cream "completely eliminated" pruritus in 38 percent of trial subjects and "significantly reduced" itching in others. (norml.org)
  • If your dog spends a large portion of his time scratching, he may have a condition known as pruritus, or itching, an unpleasant sensation that causes your dog to scratch or bite at himself. (petplace.com)
  • Pruritus may be temporarily relieved with medication but the itching often recurs after the medication is finished. (petplace.com)
  • Extreme dryness and itching are the trademarks of pruritus. (drscabies.com)
  • Pathophysiology of opioid-induced pruritus remain unclear and more than one mechanism may be involved in the development of opioid-induced pruritus, such as, mediated central µ opioid receptors, Dopamine (D2) receptors, Serotonin (5-HT3) receptors, prostaglandin system, GABA receptors, and glycine receptors, so that why opioid-induced pruritus is difficult to manage. (clinicaltrials.gov)
  • STAMFORD, Conn., June 26, 2019 (GLOBE NEWSWIRE) -- Cara Therapeutics, Inc. ( CARA ), a biopharmaceutical company focused on developing and commercializing new chemical entities designed to alleviate pruritus by selectively targeting peripheral kappa opioid receptors, today announced the initiation of a Phase 2 trial of Oral KORSUVA (CR845/difelikefalin) for the treatment of pruritus in patients with hepatic impairment due to primary biliary cholangitis (PBC). (yahoo.com)
  • Aleckovic-Halilovic et al published an article on pruritus in a dialysis patient in AJKD . (ajkdblog.org)
  • A review of the scientific literature identifies at least three clinical trials investigating the use of cannabinoids in the treatment of pruritus. (norml.org)
  • This study raises questions about the use of erythema scoring systems as a primary outcome measure in clinical trials, and also about the role of various inflammatory mediators in the pathogenesis of canine pruritus. (edu.au)
  • Taiho Pharmaceutical Co., Ltd. (HQ: Tokyo, President: Toru Usami) announced today that the licensing agreement with Nippon Shinyaku Co., Ltd. (HQ: Kyoto, President: Shigenobu Maekawa) for the new NST-141 agent for pruritus in atopic dermatitis has been cancelled by mutual consent. (taiho.co.jp)
  • The dose of Oral KORSUVA (1 mg BID) in the Phase 2 trial is based on comparison to the exposure levels achieved with 0.5 mcg/kg dose of I.V. KORSUVA that exhibited statistically significant and clinically meaningful reduction in itch intensity in hemodialysis patients with moderate-to-severe pruritus in the Phase 2 and 3 trials. (yahoo.com)
  • What Causes Pruritus? (drscabies.com)
  • This entry was posted in Pruritus and tagged What causes pruritus , What is pruritus . (drscabies.com)
  • We report the case of a 68-year-old woman with a history of triple-negative breast cancer who presented with extensive, localised cutaneous metastasis complicated by incapacitating, treatment-refractory pruritus localised to the anatomic regions involved by her metastatic disease. (bmj.com)
  • For the purpose of this discussion, a focus will be placed on pruritus in the absence of a primary dermatosis, as is often encountered in patients receiving cancer treatment. (peacehealth.org)
  • Then correction of the underlying cause (if possible) and treatment of the pruritus with currently available therapies may ensue. (peacehealth.org)
  • Discuss treatment of pruritus. (annanurse.org)
  • Pruritus is a common and often incapacitating symptom in patients with advanced kidney disease. (ajkdblog.org)
  • Pruritus is a common presenting symptom in primary care medicine that can prove distressing to the patient and frustrating for the treating doctor. (medicinetoday.com.au)
  • Despite the wide array of diseases that may present with pruritus, a systematic evaluation of the differential using a good history, review of systems, and appropriate blood work will lead to a rational and finite group of etiologies. (peacehealth.org)
  • Oral treatments for pruritus, including antihistamines, tricyclic antidepressants, benzodiazepines and opioid receptor antagonists, may offer relief in specific circumstances. (medicinetoday.com.au)
  • The Phase 2 multicenter, randomized, double-blind, placebo-controlled 16-week trial is designed to evaluate the safety and efficacy of 1 mg tablet of Oral KORSUVA taken twice daily (BID) versus placebo in approximately 60 patients with PBC and moderate-to-severe pruritus. (yahoo.com)