An intense itching sensation that produces the urge to rub or scratch the skin to obtain relief.
Agents, usually topical, that relieve itching (pruritus).
Intense chronic itching in the anal area.
Intense itching of the external female genitals.
Oleagenous substances used topically to soothe, soften or protect skin or mucous membranes. They are used also as vehicles for other dermatologic agents.
A clinical syndrome associated with the retention of renal waste products or uremic toxins in the blood. It is usually the result of RENAL INSUFFICIENCY. Most uremic toxins are end products of protein or nitrogen CATABOLISM, such as UREA or CREATININE. Severe uremia can lead to multiple organ dysfunctions with a constellation of symptoms.
Drugs that bind to but do not activate histamine receptors, thereby blocking the actions of histamine or histamine agonists. Classical antihistaminics block the histamine H1 receptors only.
Impairment of bile flow due to injury to the HEPATOCYTES; BILE CANALICULI; or the intrahepatic bile ducts (BILE DUCTS, INTRAHEPATIC).
A chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. It is manifested by lichenification, excoriation, and crusting, mainly on the flexural surfaces of the elbow and knee. In infants it is known as infantile eczema.
The relief of pain without loss of consciousness through the introduction of an analgesic agent into the epidural space of the vertebral canal. It is differentiated from ANESTHESIA, EPIDURAL which refers to the state of insensitivity to sensation.
A plant genus of the family FABACEAE that is the source of mucuna gum.
Adverse cutaneous reactions caused by ingestion, parenteral use, or local application of a drug. These may assume various morphologic patterns and produce various types of lesions.
Therapy for the insufficient cleansing of the BLOOD by the kidneys based on dialysis and including hemodialysis, PERITONEAL DIALYSIS, and HEMODIAFILTRATION.
The elimination of PAIN, without the loss of CONSCIOUSNESS, during OBSTETRIC LABOR; OBSTETRIC DELIVERY; or the POSTPARTUM PERIOD, usually through the administration of ANALGESICS.
Impairment of bile flow due to obstruction in small bile ducts (INTRAHEPATIC CHOLESTASIS) or obstruction in large bile ducts (EXTRAHEPATIC CHOLESTASIS).
Compounds with activity like OPIATE ALKALOIDS, acting at OPIOID RECEPTORS. Properties include induction of ANALGESIA or NARCOSIS.
A class of non-sedating drugs that bind to but do not activate histamine receptors (DRUG INVERSE AGONISM), thereby blocking the actions of histamine or histamine agonists. These antihistamines represent a heterogenous group of compounds with differing chemical structures, adverse effects, distribution, and metabolism. Compared to the early (first generation) antihistamines, these non-sedating antihistamines have greater receptor specificity, lower penetration of BLOOD-BRAIN BARRIER, and are less likely to cause drowsiness or psychomotor impairment.
Treatment of disease by exposure to light, especially by variously concentrated light rays or specific wavelengths.
A name applied to several itchy skin eruptions of unknown cause. The characteristic course is the formation of a dome-shaped papule with a small transient vesicle on top, followed by crusting over or lichenification. (From Dorland, 27th ed)
Any of several generalized skin disorders characterized by dryness, roughness, and scaliness, due to hypertrophy of the stratum corneum epidermis. Most are genetic, but some are acquired, developing in association with other systemic disease or genetic syndrome.
An extremely variable eczematous skin disease that is presumed to be a response to prolonged vigorous scratching, rubbing, or pinching to relieve intense pruritus. It varies in intensity, severity, course, and morphologic expression in different individuals. Neurodermatitis is believed by some to be psychogenic. The circumscribed or localized form is often referred to as lichen simplex chronicus.
The principal alkaloid in opium and the prototype opiate analgesic and narcotic. Morphine has widespread effects in the central nervous system and on smooth muscle.
High-molecular-weight insoluble polymers that contain functional cationic groups capable of undergoing exchange reactions with anions.
Gastrointestinal agents that stimulate the flow of bile into the duodenum (cholagogues) or stimulate the production of bile by the liver (choleretic).
A group of disorders characterized by physical symptoms that are affected by emotional factors and involve a single organ system, usually under AUTONOMIC NERVOUS SYSTEM control. (American Psychiatric Glossary, 1988)
Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)
Messages between computer users via COMPUTER COMMUNICATION NETWORKS. This feature duplicates most of the features of paper mail, such as forwarding, multiple copies, and attachments of images and other file types, but with a speed advantage. The term also refers to an individual message sent in this way.
Mechanical food dispensing machines.
The guidelines and policy statements set forth by the editor(s) or editorial board of a publication.
The profession of writing. Also the identity of the writer as the creator of a literary production.
A publication issued at stated, more or less regular, intervals.
The functions and activities carried out by the U.S. Postal Service, foreign postal services, and private postal services such as Federal Express.
A loose confederation of computer communication networks around the world. The networks that make up the Internet are connected through several backbone networks. The Internet grew out of the US Government ARPAnet project and was designed to facilitate information exchange.
Compounds that interact with and modulate the activity of CANNABINOID RECEPTORS.
A subclass of cannabinoid receptor found primarily on central and peripheral NEURONS where it may play a role modulating NEUROTRANSMITTER release.
Fatty acid derivatives that have specificity for CANNABINOID RECEPTORS. They are structurally distinct from CANNABINOIDS and were originally discovered as a group of endogenous CANNABINOID RECEPTOR AGONISTS.
The urea concentration of the blood stated in terms of nitrogen content. Serum (plasma) urea nitrogen is approximately 12% higher than blood urea nitrogen concentration because of the greater protein content of red blood cells. Increases in blood or serum urea nitrogen are referred to as azotemia and may have prerenal, renal, or postrenal causes. (From Saunders Dictionary & Encyclopedia of Laboratory Medicine and Technology, 1984)
A contact dermatitis due to allergic sensitization to various substances. These substances subsequently produce inflammatory reactions in the skin of those who have acquired hypersensitivity to them as a result of prior exposure.
A myeloproliferative disorder of unknown etiology, characterized by abnormal proliferation of all hematopoietic bone marrow elements and an absolute increase in red cell mass and total blood volume, associated frequently with splenomegaly, leukocytosis, and thrombocythemia. Hematopoiesis is also reactive in extramedullary sites (liver and spleen). In time myelofibrosis occurs.
A common superficial bacterial infection caused by STAPHYLOCOCCUS AUREUS or group A beta-hemolytic streptococci. Characteristics include pustular lesions that rupture and discharge a thin, amber-colored fluid that dries and forms a crust. This condition is commonly located on the face, especially about the mouth and nose.
A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.
The outer covering of the body that protects it from the environment. It is composed of the DERMIS and the EPIDERMIS.
An idiopathic vascular disorder characterized by bilateral Raynaud phenomenon, the abrupt onset of digital paleness or CYANOSIS in response to cold exposure or stress.
A term used to describe a variety of localized asymmetrical SKIN thickening that is similar to those of SYSTEMIC SCLERODERMA but without the disease features in the multiple internal organs and BLOOD VESSELS. Lesions may be characterized as patches or plaques (morphea), bands (linear), or nodules.
A chronic multi-system disorder of CONNECTIVE TISSUE. It is characterized by SCLEROSIS in the SKIN, the LUNGS, the HEART, the GASTROINTESTINAL TRACT, the KIDNEYS, and the MUSCULOSKELETAL SYSTEM. Other important features include diseased small BLOOD VESSELS and AUTOANTIBODIES. The disorder is named for its most prominent feature (hard skin), and classified into subsets by the extent of skin thickening: LIMITED SCLERODERMA and DIFFUSE SCLERODERMA.
A mild form of LIMITED SCLERODERMA, a multi-system disorder. Its features include symptoms of CALCINOSIS; RAYNAUD DISEASE; ESOPHAGEAL MOTILITY DISORDERS; sclerodactyly, and TELANGIECTASIS. When the defect in esophageal function is not prominent, it is known as CRST syndrome.
A rapid onset form of SYSTEMIC SCLERODERMA with progressive widespread SKIN thickening over the arms, the legs and the trunk, resulting in stiffness and disability.
The least progressive form of SYSTEMIC SCLERODERMA with skin thickening restricted to the face, neck and areas distal to the elbows and/or knees, sparing the trunk. The CREST SYNDROME is a form of limited scleroderma.

Reduction of sodium deoxycholic acid-induced scratching behaviour by bradykinin B2 receptor antagonists. (1/789)

1. Subcutaneous injection of sodium deoxycholic acid into the anterior of the back of male ddY mice elicited dose-dependent scratching of the injected site with the forepaws and hindpaws. 2. Up to 100 microg of sodium deoxycholic acid induced no significant increase in vascular permeability at the injection site as assessed by a dye leakage method. 3. Bradykinin (BK) B2 receptor antagonists, FR173657 and Hoe140, significantly decreased the frequency of scratching induced by sodium deoxycholic acid. 4. Treatment with aprotinin to inhibit tissue kallikrein reduced the scratching behaviour induced by sodium deoxycholic acid, whereas treatment with soybean trypsin inhibitor to inhibit plasma kallikrein did not. 5. Although injection of kininase II inhibitor, lisinopril together with sodium deoxycholic acid did not alter the scratching behaviour, phosphoramidon, a neutral endopeptidase inhibitor, significantly increased the frequency of scratching. 6. Homogenates of the skin excised from the backs of mice were subjected to gel-filtration column chromatography followed by an assay of kinin release by trypsin from each fraction separated. Less kinin release from the fractions containing kininogen of low molecular weight was observed in the skin injected with sodium deoxycholic acid than in normal skin. 7. The frequency of scratching after the injection of sodium deoxycholic acid in plasma kininogen-deficient Brown Norway Katholiek rats was significantly lower than that in normal rats of the same strain, Brown Norway Kitasato rats. 8. These results indicate that BK released from low-molecular-weight kininogen by tissue kallikrein, but not from high-molecular-weight kininogen by plasma kallikrein, may be involved in the scratching behaviour induced by the injection of sodium deoxycholic acid in the rodent.  (+info)

Observations on the use of tetracycline and niacinamide as antipruritic agents in atopic dogs. (2/789)

Tetracycline and niacinamide were administered in combination to 19 atopic dogs to determine their effectiveness in controlling pruritus. The pruritus was controlled successfully in only one dog. One dog experienced diarrhea that was severe enough to warrant stopping the medication.  (+info)

Effects of prophylactic nalmefene on the incidence of morphine-related side effects in patients receiving intravenous patient-controlled analgesia. (3/789)

BACKGROUND: Opioid-related side effects associated with intravenous patient-controlled analgesia can be reduced by a low-dose naloxone infusion. The influence of nalmefene, a pure opioid antagonist with a longer duration of action, on opioid-related side effects has not been evaluated. This study was designed to determine the dose-response relation for nalmefene for the prevention of morphine-related side effects in patients receiving intravenous patient-controlled analgesia. METHODS: One hundred twenty women undergoing lower abdominal surgery were enrolled in the study. General anesthesia was induced using thiopental and rocuronium and maintained with desflurane, nitrous oxide, and fentanyl or sufentanil. All patients received neostigmine and glycopyrrolate to reverse residual neuromuscular blockade. No prophylactic antiemetics were administered. At the end of surgery, patients were randomized to receive saline, 15 microg nalmefene, or 25 microg nalmefene intravenously. The need for antiemetic and antipruritic drugs and the total consumption of morphine during the 24-h study were recorded. The incidences of postoperative nausea, vomiting, pruritus, and pain were recorded 30 min after patients were admitted to the postanesthesia care unit. In addition, patient remembrance of these side effects was noted at 24 h after operation. RESULTS: The need for antiemetic and antipruritic medications during the 24-h study period was significantly lower in the patients receiving nahmefene compared with those receiving placebo. However, the need to treat side effects was similar in the two nahmefene groups. Prophylactic administration of nalmefene reduced the patients remembrance of nausea and itching as assessed 24 h after operation. Although the total consumption of morphine during the 24-h study period was similar in the three groups, retrospectively patients who received nalmefene characterized their pain as less severe in the previous 24 h. CONCLUSION: Compared with placebo, prophylactic administration of nalmefene significantly decreased the need for antiemetics and antipruritic medications in patients receiving intravenous patient-controlled analgesia with morphine.  (+info)

Physical symptoms and quality of life in patients on chronic dialysis: results of The Netherlands Cooperative Study on Adequacy of Dialysis (NECOSAD) (4/789)

BACKGROUND: So far, little attention has been paid to the value of dialysis adequacy for patients' quality of life (QL). Therefore we studied the impact of demographic, clinical, and dialysis characteristics on physical symptoms and perceived QL. METHODS: The study population consisted of 120 incident chronic haemodialysis (HD) and 106 peritoneal dialysis (PD) patients, starting dialysis treatment in 13 Dutch centres. Data were collected 3 months after the start of dialysis. Nine physical symptoms were assessed with a self-administered questionnaire. Patient's self-assessment of QL was measured with the 36-item MOS Short Form (SF-36). RESULTS: The most common symptoms in HD and PD were fatigue (respectively 82 and 87%) and itching (73 and 68%). In HD only a medium to high comorbidity--age risk index was associated with greater symptom burden. In PD also a lower percentage lean body mass, a lower rGFR, and past episodes of underhydration were associated with greater symptom burden. The explained variance by these variables was only 12% in HD and 21% in PD. However, greater symptom burden explained a substantial additional amount of impaired physical and mental QL on top of demographics and clinical status. Dialysis variables were associated neither with symptoms nor with QL. CONCLUSION: Symptom burden can be explained to a limited extent by demographic and clinical variables and not by dialysis characteristics. Addition of symptom burden to the other variables makes it possible to explain one-third of perceived QL. This underlines the importance of symptom reduction in order to improve patient's QL.  (+info)

Comparison of intrathecal and epidural diamorphine for elective caesarean section using a combined spinal-epidural technique. (5/789)

To assess calculated equivalent doses of intrathecal and epidural opioids for elective Caesarean section in terms of quality and duration of analgesia, and incidence of side effects, we have compared 50 patients, allocated randomly to one of two groups to receive either diamorphine 0.25 mg intrathecally (group 1) or 5 mg epidurally (group 2), in addition to intrathecal bupivacaine 10 mg, using a combined spinal-epidural technique. There was no significant difference in duration of analgesia between groups (group 1 mean 14.6 (SD 5.9) h, group 2 14.2 (6.5) h; mean difference 0.8 h; 95% Cl -2.8-4.5; P = 0.65) or quality of analgesia (VAPS and VRS scores). The degree of pruritus was similar in both groups (80-88%) but the incidence of postoperative nausea and vomiting was significantly higher in the epidural group (24% vs 4%; P < 0.05). Intrathecal diamorphine 0.25 mg produced the same duration and quality of postoperative analgesia as epidural diamorphine 5 mg for elective Caesarean section but with significantly less nausea and vomiting.  (+info)

Allelic heterogeneity of dominant and recessive COL7A1 mutations underlying epidermolysis bullosa pruriginosa. (6/789)

The inherited mechanobullous disease, dystrophic epidermolysis bullosa, is caused by type VII collagen gene (COL7A1) mutations. We studied six unrelated patients with a distinct clinical subtype of this disease, epidermolysis bullosa pruriginosa, characterized by pruritus, excoriated prurigo nodules, and skin fragility. Mutation analysis using polymerase chain reaction amplification of genomic DNA, heteroduplex analysis and direct nucleotide sequencing demonstrated pathogenetic COL7A1 mutations in each case. Four patients had a glycine substitution mutation on one COL7A1 allele (G1791E, G2242R, G2369S, and G2713R), a fifth was a compound heterozygote for a splice site mutation (5532 + 1G-to-A) and a single base pair deletion (7786delG), and a sixth patient was heterozygous for an out-of-frame deletion mutation (6863del16). This study shows that the molecular pathology in patients with the distinctive clinical features of epidermolysis bullosa pruriginosa is heterogeneous and suggests that other factors, in addition to the inherent COL7A1 mutation(s), may be responsible for an epidermolysis bullosa pruriginosa phenotype.  (+info)

Patient-controlled analgesia: epidural fentanyl and i.v. morphine compared after caesarean section. (7/789)

We have compared patient-controlled epidural fentanyl (PCEF) and patient-controlled i.v. morphine (PCIM) after Caesarean section in 84 patients, in a randomized, double-blind study. All patients had an epidural and an i.v. patient-controlled analgesia (PCA) device, one of which delivered normal saline. Group PCEF received epidural fentanyl 20 micrograms with a 10-min lockout. Group PCIM received i.v. morphine 1 mg with a 5-min lockout. PCA use was lower for PCEF patients (P = 0.0007). The highest pain score recorded at rest for PCEF patients was median 20 (interquartile range 10-33) mm compared with 32 (14-52) mm for PCIM patients (P = 0.02). The highest pain score recorded on coughing was 31 (21-41) mm with PCEF compared with 56 (30-71) mm for PCIM (P = 0.001). There was less nausea (P = 0.02) and drowsiness (P = 0.0003) with PCEF. There was no difference in the overall incidence and severity of pruritus (P = 0.77). However, pruritus started earlier with PCEF.  (+info)

Management of opioid-induced pruritus: a role for 5-HT3 antagonists? (8/789)

We have evaluated the efficacy of ondansetron in the prevention of opioid-induced pruritus in a prospective, randomized, double-blind, placebo-controlled study. Using a 'human model' of opioid-induced pruritus, 80 ASA I-II patients about to undergo routine surgery were given either ondansetron 4 mg i.v. or 0.9% saline i.v. (40 in each group), 30 min before alfentanil 10 mg kg-1 i.v. During the following 5 min, patients were observed for signs of perinasal scratching and at 5 min were asked about symptoms of pruritus. The study was then terminated and anaesthesia was induced. There was a significant reduction in the incidence of scratching in patients receiving ondansetron compared with placebo (42.5% vs 70%, respectively, P = 0.013). The incidence of itching in the ondansetron group was less than that in the placebo group but this was not statistically significant (30% vs 42.5%, respectively, P = 0.245). We conclude that the 5-HT3 antagonist ondansetron may have a role in the management of opioid-induced pruritus.  (+info)

TY - JOUR. T1 - Five-year malignancy incidence in patients with chronic pruritus. T2 - A population-based cohort study aimed at limiting unnecessary screening practices. AU - Fett, Nicole. AU - Haynes, Kevin. AU - Propert, Kathleen Joy. AU - Margolis, David J.. PY - 2014/4. Y1 - 2014/4. N2 - Background: The incidence of malignancy in patients with chronic pruritus and nondiseased skin is unknown. Objective: We sought to assess the hazard ratio (HR) of incident overall malignancy and incident malignancy by subtype in patients with chronic pruritus during the 5 years after diagnosis. Methods: A population-based cohort study was performed in the Health Improvement Network. In all, 8744 patients with chronic pruritus were matched with 31,580 patients without chronic pruritus based on sex, age, and practice. Primary outcomes were HR of incident malignancy and HR of malignancy subtypes. Results: The fully adjusted HR for incident malignancy in patients with chronic pruritus was 1.14 (95% confidence ...
The severity of pruritus and the extent and severity of erythema were quantified in 107 dogs presenting with various dermatoses. Pruritus was assessed using a previously validated scale, and erythema was quantified by assessing severity at 72 different body sites. Pruritus scores were either 0, or followed a normal type of distribution, with most dogs having a score in the middle of the range and a few dogs having low or high scores. The median pruritus score was 6.3 ⁄ 10. Erythema scores were heavily skewed towards lower values, with only a few dogs having high scores. The median diffuse erythema score was 6.0 ⁄ 216 and the median score for maculo-papular ⁄ pustular erythema was 0 ⁄ 1080. Pruritus and erythema scores were significantly correlated with a Spearman rank correlation coefficient of 0.4062 (P , 0.001). However, visual assessment of the data representing the two variables revealed that this was not a consistent biological or clinically relevant correlation. Individual dogs ...
Mycosis Fungoides (MF) is a rare malignancy in the United States. It is the most common form of cutaneous T-cell lymphoma (CTCL). Sézary syndrome (SS) is the most severe and leukemic form of CTCL. Severe pruritus is a manifestation of the SS and also affects patients with MF. Severe pruritus is a manifestation of SS and also a common symptom among patients with MF. Pruritus can significantly impact on quality of life. In one national survey of the impact of MF on patients health-related quality of life (HRQOL), the majority of survey respondents (88%) reported being bothered by pruritus.. The pathogenesis of pruritus is complex and not well understood. It affects a majority of patients with mycosis fungoides (MF) and is most severe in Sézary syndrome (SS), the leukemic form of cutaneous T-cell lymphoma. Chemical or physical stimuli that perturb, without damaging, only the epidermis (the outer most layer of the skin), elicit the symptom of pruritus. The perception of itch is abolished if the ...
Background.. Uremic pruritus is still a common phenomenon in patients with end-stage renal failure. It is regarded as one of the most bothersome symptoms in patients on chronic dialysis.. The pathogenesis of uremic itch remains unclear. Several theories have been proposed like dryness of the skin, imbalance in divalent ions, peripheral neuropathy and others.. Many treatment modalities have been tried to reduce uremic pruritus, however , the majority of them produced only temporary improvement. Therefore , every new therapeutic option for uremic pruritus is desirable.. This study will undertaken to evaluate the efficacy of a cream which included olive oil and omega-3 fatty acids.. Olive Omega-3 is an efficient product that soothes itchiness of cracked and very dry skin.. The product is unique and based on patented technology developed by the Technion Research and Development Foundation in Haifa.. Olive Omega-3 is an ointment composed of all natural ingredients. The main active ingredients are ...
If your dog spends a large portion of his time scratching, he may have a condition known as pruritus, or itching, an unpleasant sensation that causes your dog to scratch or bite at himself. It is caused by chemical reactions that occur in the skin and stimulate the nerves, causing the brain to feel the itch. In fact, the act of scratching itself may stimulate these inflammatory reactions in the skin and make the condition worse. Any skin condition that causes inflammation can cause pruritus.. How pruritus affects your dogs health depends on the degree of the pruritus. Mild pruritus may hardly have any effect at all. However, severe pruritus leads to intense scratching, which may result in painful skin lesions that may become infected. Your dog will often whimper or cry out and may have trouble sleeping ...
Easy bruising Easy bruising: Add a 4th symptom Easy bruising: Remove a symptom Pruritus: Add a 4th symptom Pruritus: Remove a symptom Temperature symptoms: Temperature symptoms Temperature symptoms: Psoriasis psychosomatische Erkrankungen a 4th symptom Temperature symptoms: Remove a symptom Results: Causes of Easy bruising AND Pruritus AND Temperature symptoms 1.. Chronic lymphocytic leukemia 2. Aantibodies anti-FVIIIc syndrome 2. Abdominal cystic lymphangioma 8. Remove a symptom Start with new symptoms How this tool works Narrow Your Search: Add a 4 th Symptom Choose another medical symptom from the list below to search in addition to the already chosen symptoms to narrow the list of potential disease causes shown: Causes Medications causing Temperatur Pruritus bruising Diagnostic Guides Diagnosis Pruritus Introduction: Pruritus Causes of Pruritus Temperature symptoms Introduction: Temperature symptoms Causes of Temperature symptoms General Information: Hematoma causes Bruising causes Bleeding ...
TY - CHAP. T1 - Pruritus. AU - Weisshaar, Elke. AU - Yosipovitch, Gil. PY - 2014/8/11. Y1 - 2014/8/11. N2 - Pruritus, or itch, is a frequent symptom in dermatology, general practice, and other fields of medicine. Chronic itch usually forms a diagnostic and therapeutic challenge. In the last decade, significant advancement has been achieved in awareness for itch, and new epidemiological studies and treatments have been published. This chapter presents an overview of different forms of common systemic pruritus and their diagnostic measures and treatment options.. AB - Pruritus, or itch, is a frequent symptom in dermatology, general practice, and other fields of medicine. Chronic itch usually forms a diagnostic and therapeutic challenge. In the last decade, significant advancement has been achieved in awareness for itch, and new epidemiological studies and treatments have been published. This chapter presents an overview of different forms of common systemic pruritus and their diagnostic measures ...
Pruritus is a common and often incapacitating symptom in patients with advanced kidney disease. It can be challenging to treat, with only few proven therapeutic options. Aleckovic-Halilovic et al published an article on pruritus in a dialysis patient in AJKD. Complete our nephrology jumble-bumble to test your knowledge on uremic pruritus! …
Definition of pruritus in the Legal Dictionary - by Free online English dictionary and encyclopedia. What is pruritus? Meaning of pruritus as a legal term. What does pruritus mean in law?
Histopathologic examination with Giemsa staining showed a dense infiltrate of mast cells (MCs) in the superficial dermis. These findings, in combination with hi
To our knowledge, this is the first study to investigate the association of pruritus with QOL and disability in SSc. The presence of pruritus on most days in the past month was significantly associated with poorer mental and physical function and greater disability, with a small effect size difference for disability and medium effect size differences for mental and physical health. Typically, a medium standardized difference effect size (approximately 0.50) is considered to be clinically meaningful (41). After controlling for sociodemographic and other disease variables, the presence of pruritus was significantly associated with mental and physical health, but not disability. The magnitude of the independent association of pruritus with QOL outcomes in multivariate analyses was small, but it is notable that it was significantly associated with QOL even after controlling for a large number of variables known to have robust associations with QOL and disability in SSc.. The results of this study ...
Data Availability StatementData posting is not applicable to this article as no data sets were generated or analyzed during the current study. visual analog scale Based on the description of two patients with metastatic non-small-cell lung cancer receiving erlotinib and successfully cured of pruritus after treatment with aprepitant [5], a single-center pilot study was designed to assess the efficacy of aprepitant for management of severe pruritus induced by biological anticancer drugs [27]. Forty-five outpatients with metastatic solid tumors treated with cetuximab, erlotinib, gefitinib, imatinib, or sunitinib were enrolled and treated with a short course of aprepitant. The study showed that aprepitant significantly decreased the severity of pruritus induced by biological anticancer treatments and could be a useful antipruritic agent both as the first-choice treatment or after failure of standard antipruritic therapy (Table?2) [27]. In another retrospective, analytical study, promising ...
Aquagenic pruritus is a skin condition characterized by the development of severe, intense, prickling-like epidermal itching without observable skin lesions and evoked by contact with water. Symptoms occur for up to 35 minutes; duration of an attack is typically between 10 and 120 minutes. However, sensitivity varies among sufferers, and since water is always present to some extent in the air (atmospheric humidity), those with greater sensitivity who live in moister regions are symptomatic almost constantly, while perspiration can cause frequent symptoms even in the driest climates. No definitive medical test is known for aquagenic pruritus. Rather, the diagnosis is made by excluding all other possible causes of the patients itching. Some of which includes polycythemia vera. Since pruritus is a symptom of many serious diseases, it is important to rule out other causes before making a final diagnosis. The name is derived from Latin: aquagenic, meaning water-induced, and pruritus, meaning itch. ...
Symptoms of Brachioradial pruritus including 9 medical symptoms and signs of Brachioradial pruritus, alternative diagnoses, misdiagnosis, and correct diagnosis for Brachioradial pruritus signs or Brachioradial pruritus symptoms.
The Pruritus Therapeutics Market report presents a calculated opinion of the analyzed Pruritus Therapeutics Market data. It explains various opportunities dedicated to different industries, suppliers, organizations, and associations offering various products and services such as offering them precise guidance for their expansion in the competition for reliable services to consumers. The report provides detailed information on key competitors in the market and on emerging companies with significant market share based on demand, revenue, sales, high-quality product manufacturers, and service providers.. Request Brochure of this Pruritus Therapeutics Market Report For More Industry Insights @ CLICK HERE NOW. Analysis based on competence and estimation of the global Pruritus Therapeutics Market is crafted through assessable methods to attain a clear insight of current and expected growth patterns. The report also contains the market distribution based on the geographical location around the globe ...
in nociceptors expressing transient receptor potential vanilloid 1 (TRPV1). BRAFNav1.8 mice showed de novo neuronal responsiveness to pruritogens, enhanced pruriceptor excitability, and heightened evoked and spontaneous scratching behavior. GRP receptor expression was increased in the spinal cord, indicating augmented coding capacity for itch subsequent to amplified pruriceptive inputs. Enhanced GRP expression and sustained ERK phosphorylation were observed in sensory neurons of mice with allergic contact dermatitis- or dry skin-elicited itch; however, spinal ERK activation was not required for maintaining central sensitization of itch. Inhibition of either BRAF or GRP signaling attenuated itch sensation in chronic itch mouse models. These data uncover RAF/MEK/ERK signaling as a key regulator that confers a subset of nociceptors with pruriceptive properties to initiate and maintain long-lasting itch sensation. ...
in nociceptors expressing transient receptor potential vanilloid 1 (TRPV1). BRAFNav1.8 mice showed de novo neuronal responsiveness to pruritogens, enhanced pruriceptor excitability, and heightened evoked and spontaneous scratching behavior. GRP receptor expression was increased in the spinal cord, indicating augmented coding capacity for itch subsequent to amplified pruriceptive inputs. Enhanced GRP expression and sustained ERK phosphorylation were observed in sensory neurons of mice with allergic contact dermatitis- or dry skin-elicited itch; however, spinal ERK activation was not required for maintaining central sensitization of itch. Inhibition of either BRAF or GRP signaling attenuated itch sensation in chronic itch mouse models. These data uncover RAF/MEK/ERK signaling as a key regulator that confers a subset of nociceptors with pruriceptive properties to initiate and maintain long-lasting itch sensation. ...
in nociceptors expressing transient receptor potential vanilloid 1 (TRPV1). BRAFNav1.8 mice showed de novo neuronal responsiveness to pruritogens, enhanced pruriceptor excitability, and heightened evoked and spontaneous scratching behavior. GRP receptor expression was increased in the spinal cord, indicating augmented coding capacity for itch subsequent to amplified pruriceptive inputs. Enhanced GRP expression and sustained ERK phosphorylation were observed in sensory neurons of mice with allergic contact dermatitis- or dry skin-elicited itch; however, spinal ERK activation was not required for maintaining central sensitization of itch. Inhibition of either BRAF or GRP signaling attenuated itch sensation in chronic itch mouse models. These data uncover RAF/MEK/ERK signaling as a key regulator that confers a subset of nociceptors with pruriceptive properties to initiate and maintain long-lasting itch sensation. ...
Itching is an unpleasant sensation associated with the desire to scratch, and the itch sensation is an important protective mechanism for animals. However, chronic itch, often seen in patients with skin and liver diseases, ...
The mechanisms that generate itch are poorly understood at both the molecular and cellular levels despite its clinical importance. To explore the peripheral neuronal mechanisms underlying itch, we assessed the behavioral responses (scratching) produced by s.c. injection of various pruritogens in PLCbeta3- or TRPV1-deficient mice. We provide evidence that at least 3 different molecular pathways contribute to the transduction of itch responses to different pruritogens: 1) histamine requires the function of both PLCbeta3 and the TRPV1 channel; 2) serotonin, or a selective agonist, alpha-methyl-serotonin (alpha-Me-5-HT), requires the presence of PLCbeta3 but not TRPV1, and 3) endothelin-1 (ET-1) does not require either PLCbeta3 or TRPV1. To determine whether the activity of these molecules is represented in a particular subpopulation of sensory neurons, we examined the behavioral consequences of selectively eliminating 2 nonoverlapping subsets of nociceptors. The genetic ablation of MrgprD(+) ...
article: Pruritus is not sensorial in psoriasis: the mutual interactions between dermatologic life quality and pruritus - Gazzetta Medica Italiana - Archivio per le Scienze Mediche 2019 May;178(5):301-6 - Minerva Medica - Riviste
Itching (pruritus) is a common symptom associated with numerous skin diseases, as well as a secondary symptom of numerous serious conditions such as renal failure and liver disease. Itching, unlike other skin sensations, is generally a result of CNS activities and typically goes untreated by standard medical therapies.. The endocannabinoid system is acknowledged to play an important role in maintaining skin health[1] and cannabinoids have been regarded as promising agents for the treatment of itch.[2]. A review of the scientific literature identifies at least three clinical trials investigating the use of cannabinoids in the treatment of pruritus. Writing in the August 2002 issue of the American Journal of Gastroentrology, investigators from the University of Miami Department of Medicine reported successful treatment of pruritus with 5 mg of THC in three patients with cholestatic liver disease.[3] Prior to cannabinoid therapy, subjects had failed to respond to standard medications and had lost ...
A recent study carried out by Dr. Sun Yangangs lab at the Institute of Neuroscience of the Chinese Academy of Sciences discovered a central neural circuit that is critical for transmitting the itch signal. By using optogenetic, chemogenetic, patch clamp recording, and in vivo fiber photometry techniques, the researchers demonstrated that the spino-parabrachial pathway plays a key role in transmitting itch signals from the spinal cord to the brain, and identified the parabrachial nucleus as a first central relay for the itch sensation.
Pruritus - Pipeline Review, H1 2017, provides an overview of the Pruritus (Dermatology) pipeline landscape. Pruritus, or itch, is defined as an unpleasant
1 Pisoni RL, Wikstrom B, Elder SJ, Akizawa T, 5 Razeghi E, Eskandari D, Ganji MR, Meysamie 10 Lee SH, Baig M, Rusciano V, Dutcher JP: Asano Y, Keen ML, Saran R, Mendelssohn AP, Togha M, Khashayar P: Gabapentin and Novel management of pruritus in patients DC, Young EW, Port FK: Pruritus in haemo- uremic pruritus in hemodialysis patients. Ren treated with IL-2 for metastatic renal cell car- dialysis patients: international results from Fail 2009; 31: 85-90. cinoma and malignant melanoma. J Immu- the Dialysis Outcomes and Practice Patterns 6 Aperis G, Paliouras C, Zervos A, Arvanitis A, notherapy 2010; 33: 1010-1013. Study (DOPPS). Nephrol Dial Transplant Alivanis P: The use of pregabalin in the treat- 11 Bergasa NV, McGee M, Ginsburg IH, Engler 2006; 21: 3495-3505. ment of uraemic pruritus in haemodialysis D: Gabapentin in patients with the pruritus of 2 Gunal AI, Ozalp G, Yoldas TK, Gunal SY, patients. J Ren Care 2010; 36: 180-185. cholestasis: a double-blind, randomized, pla- Kirciman E, Celiker ...
Pruritus is a debilitating symptom that can be associated with cutaneous involvement by an underlying malignancy. We report the case of a 68-year-old woman with a history of triple-negative breast cancer who presented with extensive, localised cutaneous metastasis complicated by incapacitating, treatment-refractory pruritus localised to the anatomic regions involved by her metastatic disease. Physical examination revealed an indurated, ecchymotic, ulcerated plaque circumferentially encasing her thorax. Histopathological examination revealed substantial dermal lymphatic involvement and dilation as well as dermal collagen infiltration by tumour cells and nodules. The clinical and pathological findings were consistent with a diagnosis of carcinoma en cuirasse. Mirtazapine, a noradrenergic antidepressant with antiserotonin and antihistamine activity, was started and led to rapid, sustained relief of the patients pruritus. Mirtazapine may be a useful systemic agent for the palliative relief of ...
Find the best vaginal pruritus doctors in Thane. Get guidance from medical experts to select vaginal pruritus specialist in Thane from trusted hospitals - credihealth.com
Itch is an unpleasant sensation that evokes behavioral responses such as scratching the skin. Interestingly, it is conceived that the perception of itch sensation is influenced by age. Indeed, accumulating evidence supports the idea that even children or younger adults show distinctive itch sensation depending on age. This evidence implies the presence of a mechanism that regulates the perception of itch sensation in an age-dependent fashion. Therefore, the purpose of the present study was to investigate a putative mechanism for the age-dependent perception of itch sensation by comparing histamine-induced scratching behaviors in 45-day old (D45) and 75-day old male young adult mice ...
A new study has shown that Gabapentin can be an effective drug against uremic pruritus suffered by patients with advanced chronic kidney disease. The study was also suggested that Gabapentin may also be the only effective drug against it. (1). Uremic pruritus is a disease characterized by continuous bouts of itching throughout the body. It often worsens during the night causing patients sleeplessness or insomnia. Separate studies have shown that almost 46% of patients undergoing dialysis suffer from uremic pruritus.. This comes after the research team claimed that other treatments tested for the disease were weak and limited by small studies with a high risk of bias. The team was led by Claudio Rigatto, MD, MSc, of the University of Manitoba in Winnepeg, Canada. Their statement was reported online ahead of print in the American Journal of Kidney Diseases.. The study was conducted by assessing patients with chronic kidney disease, stage 3 or higher, or undergoing any form of dialysis on 44 ...
Hypothesis: Pruritus or itch is the most common skin symptom in elderly patients and is estimated to affect more than 30% of nursing home patients. Clinical and experimental evidence suggests pruritus in elderly patients may be linked to pemphigoid. Pemphigoid is the most common autoimmune skin blistering diseases and mainly affects the elderly. It is successfully treatable with systemic therapy. However, pemphigoid is often missed as a cause of pruritus in elderly patients. Although nursing home patients and patients with dementia in particular have the highest risk for development of pemphigoid, no study has been performed in this population so far. Including serological screening for pemphigoid in the diagnostic evaluation of chronic pruritus in nursing home patients may lead to the diagnosis of pemphigoid. Furthermore, chronic itch may be an unrecognized cause of neuropsychiatric symptoms in nursing home patients with dementia ...
suffer from chronic cough with approximately 3 million having refractory chronic cough lasting for more than a year and approximately 6 million having refractory chronic cough lasting more than 8 weeks and under one year. It is estimated that approximately 55% of patients have mild disease, and approximately 45% have moderate to severe disease. There is no specific therapy approved for refractory chronic cough and current treatment options are limited. Chronic pruritus, commonly known as chronic itch, is an irritating sensation that leads to scratching, and persists for longer than six weeks, which can be debilitating and has a significant impact on quality-of-life. It is a hallmark of many conditions, including atopic dermatitis (AD). It is estimated that chronic pruritus associated with AD affects more than 16.9 million adults in ...
suffer from chronic cough with more than 2.6 million having refractory chronic cough lasting for more than a year. There is no specific therapy approved for refractory chronic cough and treatment options are limited. Chronic pruritus, commonly known as chronic itch, is an irritating sensation that leads to scratching, and persists for longer than six weeks, which can be debilitating and has a significant impact on quality-of-life. It is a hallmark of many conditions, including atopic dermatitis (AD). It is estimated that chronic pruritus associated with AD affects more than 16.9 million adults in ...
Introduction : Pruritus is a common and troublesome side effect of end stage renal disease. It can directly influences on quality of life in affected patients. Unfortunately present treatment options are not successful in alleviating this symptom and yet kidney transplantation is the best option. Since one of the recent therapies in ...
BioMed Research International is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies covering a wide range of subjects in life sciences and medicine. The journal is divided into 55 subject areas.
Here, we identify the BRAF pathway as an upstream regulator of expression of a cohort of itch mediators in mouse sensory neurons. Our data further demonstrate that GRP/GRPR signaling plays an important role in the initiation and maintenance of long-lasting itch in 3 distinct genetic and/or clinically relevant chronic itch models. Finally, our data suggest that a phenotypic switch from nociceptors to pruriceptors underlies the transition from acute itch signaling to pathological itch state.. BRAFNav1.8 mice are a new and unique genetic model for unraveling how pruriceptive transmission is progressively enhanced at the molecular and circuit levels, as increasing scratching behavior correlates well with an expression profile change of itch mediators. The fact that enhanced evoked scratching preceded the manifestation of spontaneous itch (from 3 weeks of age to around 6 weeks of age) suggests the existence of a postnatal period for developmental maturation of itch circuitry as well as a threshold ...
Background Patients who suffer from chronic itch employ creative techniques to alleviate their itch, often using painful thermal stimuli, such as hot and very cold showers, as well as mechanical stimuli, such as scratching.. Objectives The present study examined whether the sensory perception of itch is attenuated by remote interactions between both thermal and mechanical stimuli and afferent information related to itch.. Patients and methods Itch was induced with histamine iontophoresis in 21 healthy young subjects. Repetitive thermal stimuli including innocuous warmth, innocuous cool, noxious cold and noxious heat as well as scratching were applied 3-cm distal to the area of histamine iontophoresis. Subjects rated their perceived intensity of histamine-induced itch with a computerized visual analogue scale.. Results Itch intensity ratings were significantly reduced during each period of scratching and repeated noxious heat and cold. Innocuous cooling and warming did not significantly alter ...
Taiho Pharmaceutical Co., Ltd. (HQ: Tokyo, President: Toru Usami) announced today that the licensing agreement with Nippon Shinyaku Co., Ltd. (HQ: Kyoto, President: Shigenobu Maekawa) for the new NST-141 agent for pruritus in atopic dermatitis has been cancelled by mutual consent.. Discovered by Nippon Shinyaku Co., Ltd., NST-141 is a new antipruritic agent for external administration. The said agreement covering joint development and collaborative marketing in Japan had been concluded on October 1, 2008.. ...
There does not appear to be any one underlying cause for delusional parasitosis, although it probably has to do with fundamental aspects of brain chemistry. This syndrome is often classified into three types according to the underlying condition as below. However, there is increasing literature on itch and chronic pruritus (itch) that indicate that delusional parasitosis may not be a psychiatric syndrome per se and instead may have a fundamental origin in the itch nerve pathways between the skin and the brain. There are many physiological syndromes that cause the symptoms ascribed to delusional parasitosis.. Delusional Infestation and Chronic Pruritus: A Review Primary Psychotic Delusional Parasitosis ...
Patients suffering from cholestasis often report experiencing a debilitating, unrelenting itch. In contrast to conditions, such as urticaria, in which histamine primarily drives itch (pruritus), cholestatic pruritus is multifactorial and more difficult to treat. Existing therapies are not always eff …
Cholestatic pruritus is the sensation of itch due to nearly any liver disease, but the most commonly associated entities are primary biliary cirrhosis, primary sclerosing cholangitis, obstructive choledocholithiasis, carcinoma of the bile duct, cholestasis (also see drug-induced pruritus), and chronic hepatitis C viral infection and other forms of viral hepatitis. Cholestasis means the slowing or stopping of bile flow which can be caused by any number of diseases of the liver (which produces the bile), the gallbladder (which stores the bile), or biliary tract (also known as the biliary tree, the conduit that allows the bile to leave the liver and gallbladder and enter the small intestine). When this occurs, conjugated bilirubin and the waste products that usually would be cleared in bile reflux back into the bloodstream. This causes a primarily conjugated hyperbilirubinemia and jaundice; the liver conjugates the bile to make it water-soluble and because the bile has already been processed by ...
The report segments the pruritus therapeutics market on the basis of type, disease type and geography. Pruritus is a chronic itching condition caused due to dermatological disease including atopic dermatitis, contact dermatitis, mycoses, chickenpox etc.
Pruritus Therapeutics Market - The report covers forecast and analysis for the pruritus therapeutics market on a global and regional level. The study provi
Pruritus or itching is defined as skin condition being marked with itching and dryness. Here is a rundown of causes, symptoms and prevention of pruritus.
Introduction: Neuropathy is a frequent complication of uremic disease, causing motor and sensorial symptoms, mostly localized in the lower limbs. Another symptom related to uremic disease is pruritus, which may be diffuse all over the body, but usually occurring in the lower limbs. In the terminal phase therapeutic measures are taken, targeting the sensitive components of neuropathy, with the use of drugs against pain, and targeting itching, using different substances, the most widely used of which is gabapentin.Methods: The severity of neuropathy is variable, ranging from slight to severe and may or may not be associated with the length of chronic dialysis treatment. The use of measurement scales of pain, VAS type adapted to the itching, may link both conditions of neuropathy and itching. Results: We noted that a severe intensity of pruritus can be related to severity of neuropathy in uremic subjects and may become predictive of progressing neuropathy.Conclusions: In this study we examined a group
Pruritus is a common presenting symptom in primary care medicine that can prove distressing to the patient and frustrating for the treating doctor. Here is a practical approach to the diagnosis of its causes and its management, including a discussion of some less familiar conditions in which pruritus is a feature.. ...
Feeling PRURITUS while using Tylenol? PRURITUS Causes, Patient Concerns and Latest Treatments and Tylenol Reports and Side Effects.
Feeling PRURITUS while using OMEPRAZOLE? PRURITUS Causes, Patient Concerns and Latest Treatments and OMEPRAZOLE Reports and Side Effects.
Pruritus is a common manifestation of dermatologic diseases, including xerotic eczema, atopic dermatitis, and allergic contact dermatitis. Effective treatment of pruritus can prevent scratch-induced complications such as lichen simplex chronicus and impetigo. Patients, particularly elderly adults, with severe pruritus that does not respond to conservative therapy should be evaluated for an underlying systemic disease. Causes of systemic pruritus include uremia, cholestasis, polycythemia vera, Hodgkins lymphoma, hyperthyroidism, and human immunodeficiency virus (HIV) infection. Skin scraping, biopsy, or culture may be indicated if skin lesions are present. Diagnostic testing is directed by the clinical evaluation and may include a complete blood count and measurement of thyroid-stimulating hormone, serum bilirubin, alkaline phosphatase, serum creatinine, and blood urea nitrogen levels. Chest radiography and testing for HIV infection may be indicated in some patients. Management of nonspecific pruritus
Itching of the anus is a common condition afflicting up to 5% of the population.2 The incidence of primary and secondary pruritus ani varies among different studies. Several studies show that the incidence of idiopathic pruritus ani is 75-95%.9 Other authors have found that its incidence is only 25%.10 Characteristically, pruritus ani is exacerbated by friction or a warm moist perineal environment. Poor anal hygiene or, in contrast, overcleansing with soap is often a contributing factor. Patients with idiopathic pruritus ani have been found to have abnormal transient internal sphincter relaxation11 and an abnormally profound decrease in anal canal pressure during rectal distention, as well as early incontinence on saline continence tests, implying that intermittent seepage from the anal canal may be a causative factor.12 A decrease in resting anal canal pressure with coffee intake has also been reported13 which may explain the documented exacerbation of symptoms with ingestion of caffeine. ...
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What are the aims of this leaflet?. This leaflet has been written to help you understand more about pruritus which means itching. It tells you what it is, what its causes are, what can be done about it, and where you can find out more information about it. This leaflet does not specifically cover itch in children or pruritus in pregnancy.. What is pruritus?. Pruritus (itching) refers to a sensation of the skin which causes a desire to scratch.. Itching is a normal body response to protect us from harmful external substances or parasites such as insect bites. However, pruritus (or itch) is a common and distressing symptom of many skin diseases, systemic illnesses and psychological disorders.. Itch is perhaps the commonest presenting symptom of skin disorders. In any two week period, 8-9% of the population suffer from significant pruritus. Pruritus lasting more than 6 weeks is called chronic pruritus. Pruritus may be localised to one area or generalized all over the skin.. What causes pruritus ...
What are the aims of this leaflet?. This leaflet has been written to help you understand more about pruritus which means itching. It tells you what it is, what its causes are, what can be done about it, and where you can find out more information about it. This leaflet does not specifically cover itch in children or pruritus in pregnancy.. What is pruritus?. Pruritus (itching) refers to a sensation of the skin which causes a desire to scratch.. Itching is a normal body response to protect us from harmful external substances or parasites such as insect bites. However, pruritus (or itch) is a common and distressing symptom of many skin diseases, systemic illnesses and psychological disorders.. Itch is perhaps the commonest presenting symptom of skin disorders. In any two week period, 8-9% of the population suffer from significant pruritus. Pruritus lasting more than 6 weeks is called chronic pruritus. Pruritus may be localised to one area or generalized all over the skin.. What causes pruritus ...
1152 attendants comprising 40% mole and 60% female subjects at urban private clinics and rural health centres in Ghana were interviewed by questionnaire. Enquiry was made into the occurrence of chloroquine-induced pruritus in themselves, their spouses, their children, their siblings and their parents. The questionnaire included the following details:- (a) self-medication for febrile illnesses (b) the number of tablets of chloroquine that induced pruritus. (c) the time of onset and duration of pruritus (d) the method of relief of pruritus 44.8% of respondents had experienced itching on taking chloroquine. 23.3% itched on being given chloroquine intramuscularly and 95% of these itched on oral chloroquine. The rate of itching on self-medication with chloroquine alone or with other drugs was 41%. 33.9% itched each time they took chloroquine and 30.9% itched at least once after taking chloroquine. The prevalence rate of chloroquine induced pruritus in this study was found to be between 30. 9% and ...
This dose-escalation study assessed the safety, tolerability, and pharmacokinetics of oral nalbuphine in haemodialysis patients with uremic pruritus. This study
Another name for Pruritus Vulvae is Pruritus Vulvae. The treatment for pruritus vulvae depends on the cause. Treatment for pruritus vulvae may include ...
Science 24 May 2013: Vol. 340 no. 6135 pp. 968-971 The Cells and Circuitry for Itch Responses in Mice. Santosh K. Mishra, Mark A. Hoon. Molecular Genetics Unit, Laboratory of Sensory Biology, National Institute of Dental and Craniofacial Research (NIDCR), NIH, Building 49, Room 1A16, 49 Convent Drive, Bethesda, MD 20892, USA.. [paraphrase]. Itch is triggered by somatosensory neurons expressing the ion channel TRPV1 (transient receptor potential cation channel subfamily V member 1), but the mechanisms underlying this nociceptive response remain poorly understood. Here, we show that the neuropeptide natriuretic polypeptide b (Nppb) is expressed in a subset of TRPV1 neurons and found that Nppb−/− mice selectively lose almost all behavioral responses to itch-inducing agents. Nppb triggered potent scratching when injected intrathecally in wild-type and Nppb−/− mice, showing that this neuropeptide evokes itch when released from somatosensory neurons. Itch responses were blocked by ...
Being one of the most common dermatological problems, pruritus ani is often defined as an unpleasant skin sensation. Though it is not a life threatening ailment, yet the great urge to scratch which occurs due to this problem is highly irritating. Find out in detail about the causes and treatment here. What does the term pruritus means? Basically, it is a medical term which refers to itching… which can make you feel worse at anytime of the day! Do you know it can results in damage and scarring on the skin surface? Yes, due to the damage of the skin surface, it then serves as an entry point for the microbes. Hence, increasing the chances of infection by manifold! As far as the occurrence of pruritus on the skin is concerned, it might be caused due anything ranging from mild skin disorder to a highly serious systemic disease condition. And on the other hand, irritation or itching may be induced due to any material, when the infested come into contact physically. Now the question arises;What is
Lateral habenula (LHb) is a brain region acting as a hub mediating aversive response against noxious, stressful stimuli. Growing evidences indicated that LHb modulates aminergic activities to induce avoidance behavior against nociceptive stimuli. Given overlapped neural circuitry transmitting pain and itch information, it is likely that LHb have a role in processing itch information. Here, we examined whether LHb is involved in itchy response induced by histamine. We found that histamine injection enhances Fos (+) cells in posterior portion within parvocellular and central subnuclei of the medial division (LHbM) of the LHb. Moreover, chemogenetic suppression of LHbM reduced scratching behavior induced by histamine injection. These results suggest that LHb is required for processing itch information to induce histaminergic itchy response.
TY - JOUR. T1 - Psychological management of wound pruritus. AU - UPTON, Dominic. AU - Penn, F. AU - Richardson, Cliff. AU - Rippon, Mark. PY - 2014. Y1 - 2014. N2 - Objective: To explore the psychological treatment options for pruritus in patients with wounds. Method: This study employed a narrative design with a search being completed using the databases Academic Search Complete, Google Scholar, PsycInfo, PsycARTICLES, Medline and CINAHL Plus. All articles between 1980-2013 that included the following search terms: [pruritus OR itch OR itching] AND [management OR psychological interventions OR treatment] AND [wounds OR burns OR wounds burns] wre included in the review. Results: A number of psychological treatments options merged from the literature search that were suggested to be effective for treating itching. These included methods such as habit reversal, suggestions, relaxation, massage and itch-coping programmes. Each of these methods showed potential for improving the patient experience ...
Title:RELIEF OF THE PRURITUS OF JAUNDICE WITH METHANDROSTENOLONE AND SPECULATIONS ON THE NATURE OF PRURITUS IN LIVER DISEASE.,Author:ALVA J,IBER F L,Journal:Am J Med Sci,1965/7;250:60-5.,Publication t...
WELTER, Elisângela de Quevedo et al. Relationship between pruritus and quality of life in patients on hemodialysis. An. Bras. Dermatol. [online]. 2008, vol.83, n.2, pp.137-140. ISSN 0365-0596. http://dx.doi.org/10.1590/S0365-05962008000200006.. INTRODUCTION: Pruritus is a frequent symptom affecting patients on hemodialysis. Its etiology is not known and treatment is difficult. This symptom considerably worsens the patients quality of life. OBJECTIVES: To evaluate the degree of pruritus and its influence on the quality of life of patients on hemodialysis. METHODS: Patients with chronic renal disease on hemodialysis and presenting pruritus in a Hospital of Porto Alegre were enrolled in this transversal study. A visual analogue scale for measuring the degree of pruritus was used and the Dermatology Life Quality Index questionnaire was applied. RESULTS: Of 200 evaluated patients; 69 (34.5%) presented pruritus, of whom 16 (23%) of mild degree, 39 (56.5%) moderate, 14 (20.2%) severe. Quality of life ...
Rifampicin is a semisynthetic antibiotic derived from the rifamycins, a group of antibacterials produced by Streptomyces mediterranei. Rifampicin was initially developed to treat tuberculosis but more recently has been used against other bacteria. The beneficial effect of rifampicin on pruritus was initially discovered serendipitously. Four formal studies (three of which were randomised controlled trials) have suggested a subjective effect of rifampicin on itch severity.10-13 These studies also suggested that rifampicin was better at relieving itch than other hepatic enzyme inducing agents such as phenobarbitone.10 A single small study failed to confirm the effectiveness of rifampicin for subjective itching in cholestatic liver disease (including three patients with PBC).18 All of these studies used subjective measures of itch severity (for example, visual analogue scales). To our knowledge no trial of rifampicin in cholestasis has examined efficacy in terms of objective changes in scratching ...
TY - JOUR. T1 - Treatment of atopic dermatitis. AU - Han, Tae Young. AU - Na, Chan Ho. AU - Lee, Ji Hyun. AU - Kim, Hye One. AU - Park, Chang Ook. AU - Seo, Young Joon. AU - Son, Sang Wook. AU - Shin, Min Kyung. AU - Ahn, Ji Young. AU - Lee, Yang Won. AU - Jang, Yong Hyun. AU - Park, Young Lip. AU - Lew, Bark Lynn. PY - 2018/12/1. Y1 - 2018/12/1. N2 - Atopic dermatitis (AD) is a common, chronic, relapsing, inflammatory skin disease that affects both children and adults. AD is the cause of considerable morbidity including severe pruritus and impaired quality of life. Treatments for active disease include avoidance of triggering factors, barrier repair, topical medications including topical corticosteroids (TCs) and topical calcineurin inhibitors (TCIs), phototherapy, antibacterial agents, and systemic immunosuppressants including cyclosporine. Until recently, the only Food and Drug Administration (FDA)-approved systemic treatment options for patients with moderate-to-severe AD were steroids and ...
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Lausanne - July 25, 2017- Galderma announced today the enrollment of the first patient in a multicenter double-blind Phase IIb clinical trial to evaluate nemolizumab, its investigational subcutaneous anti-IL-31 receptor A (RA) monoclonal antibody, in patients with atopic dermatitis (AD). The trial is designed to assess the efficacy of nemolizumab in moderate-to-severe AD subjects with severe pruritus receiving topical corticosteroids, who were not adequately controlled with topical treatments. Patients will be randomized to receive one of three active doses of nemolizumab or placebo administered once a month for 6 months. The safety, tolerability and pharmacokinetics of nemolizumab will also be assessed in this study ...
Urticaria (hives) is a vascular reaction of the skin marked by the transient appearance of smooth, slightly elevated patches (wheals) that are erythematous and that are often attended by severe pruritus. Individual lesions resolve without scarring in several hours.
Shire plc today announced that the 13-week Phase 2 IMAGO trial of its investigational compound SHP625 (LUM001) did not meet the primary or secondary endpoints in the study of 20 pediatric patients with Alagille syndrome (ALGS), a rare, life-threatening genetic disorder that presents with chronic cholestasis (accumulation of bile acids in the liver) and severe pruritus (itching).
Botanix Pharmaceuticals has today updated the market with plans for its Atopic Dermatitis (AD) clinical program. This follows important recent learnings on drug dose and formulation design of synthetic CBD in dermatitis applications, together with positive data from a new pilot study conducted in canines with AD.. Canine atopic dermatitis is clinically and immunologically similar to human AD, providing an efficient approach to inform progression of further human studies too.. A recent pilot study of Botanixs BTX 1204A product in canines (a new higher dose formulation of synthetic CBD for atopic dermatitis, leveraging PermetrexTM), demonstrated significant reductions on average in both the Enhanced Pruritus Score (ESP) and Canine Atopic Dermatitis Extent and Severity Index (CADESI-04) scores over the 28-day treatment period.. Botanix is now advancing plans for a larger BTX 1204A proof of concept canine study in Australia, with goals to confirm and expand safety and efficacy data. Following this, ...
When youre hungry and in need of a quick snack, simply heat up some ghee, toss in some bananas, and watch them sizzle. A dash of spices, cinnamon and ginger, make these morsels quite delicious! This rich, nourishing snack couldnt be easier to make or ...
Introduction : Atopic dermatitis (AD) is a chronic and relapsing inflammatory skin disease, characterized by eczematous skin lesions and intensive pruritus. Recent studies have shed light on the role of the nervous system in the pathogenesis of AD. It can influence the course of the disease...
List of 36 causes for Abdomen blister and Pruritus in children and Skull itch, alternative diagnoses, rare causes, misdiagnoses, patient stories, and much more.
When Hemorrhoids Itch Are They Healing? Itching is one of the most common symptoms. In most cases, hemorrhoids itch because of mucus, feces and bad hygiene not because they are healing. In most cases, proper early treatment can take care of the condition.
Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Potently activated by enkephalins including BAM22 (bovine adrenal medulla peptide 22) and BAM (8-22)(PubMed:26582731). BAM22 is the most potent compound and evoked a large and dose-dependent release of intracellular calcium in stably transfected cells. G(alpha)q proteins are involved in the calcium-signaling pathway. Activated by the antimalarial drug, chloroquine. May mediate chloroquine-induced itch, in a histamine-independent manner.
List of 53 causes for Hand and foot rashes due to skin disorders in children and Itchy scalp and Pruritus ani and Scabs, alternative diagnoses, rare causes, misdiagnoses, patient stories, and much more.
Other medications that may provide relief against pruritus in addition to antihistamines (eg, diphenhydramine, hydroxyzine) and ammonium lactate 12% skin cream (Lac-Hydrin), include ursodeox... more
This case report describes the occurrence of adverse effects after application of topical neuromodulators for the treatment of pruritus.
Facial Redness & Gout & Pruritus Symptom Checker: Possible causes include Polycythemia Vera. Check the full list of possible causes and conditions now! Talk to our Chatbot to narrow down your search.
Finally I Found This Name For This!!!! : A true, personal story from the experience, I Have Aquagenic Pruritus. I am 34 years old, living in Florida my whole life and have experienced brutally itchy legs after showers for years. I have mentioned it to dermatologists and even a neurologist time after time with n...
List of 60 causes for Abdomen blister and Pruritus in children and Rash in children, alternative diagnoses, rare causes, misdiagnoses, patient stories, and much more.
List of 34 causes for Neck rash and Pruritus ani, alternative diagnoses, rare causes, misdiagnoses, patient stories, and much more.
BOONTON, N.J., June 27, 2019 /PRNewswire/ -- Enteris BioPharma, Inc., a biotechnology company developing innovative drug products built around its proprietary delivery technologies, congratulates Cara Therapeutics (Nasdaq: CARA) on the successful initiation of its Phase 2 clinical trial of Oral KORSUVA™ (CR845/difelikefalin) for the treatment of pruritus in patients with hepatic impairment due to primary biliary cholangitis (PBC). The tablet formulation of Oral KORSUVA was engineered using Enteris proprietary oral peptide delivery technology, Peptelligence®. The Oral KORSUVA Phase 2 initiation in pruritis associated with PBC follows a Phase 1 trial in patients with hepatic impairment, which successfully established the Oral KORSUVA tablet strength. Building upon that study, the Phase 2 trial is a multicenter, randomized, double-blind, placebo-controlled 16-week trial designed to evaluate the safety and efficacy of 1 mg tablet of Oral KORSUVA taken twice daily (BID) versus placebo in ...
Congestion, sneezing, rhinorrhea, and pruritus symptom scores for controls and patients with NARES, before and after NSNPT with histamine. Data are presented as
Looking for a cure for fatty liver?: Pruritus Related To Fatty Liver. The Fatty Liver Site, Tips and natural treatments for fatty liver.
Pruritus ani means a persistent itchy feeling around the anus. Its a common condition in both adults and children. In fact, 1 in 20 people will develop it at s
Chronic idiopathic pruritus or essential pruritus is a rare form of itch that persists for longer than six weeks, and for which ... Itch (also known as pruritus) is a sensation that causes the desire or reflex to scratch. Itch has resisted many attempts to be ... "Essential pruritus". Retrieved 25 July 2019. Schmelz M, Schmidt R, Bickel A, Handwerker HO, Torebjörk HE (October 1997). " ... "Pruritus". National Cancer Institute. 2003. Archived from the original on 25 December 2005. Retrieved 22 August 2005.. ...
... pruritus; pemphigoid. In 2015, the U.S. Food and Drug Administration (FDA) added a new Warning and Precaution about the risk of ...
Pruritus. *Urticaria. *Disturbances of micturition (dysuria, polyuria, tenesmus). *Metrorrhagia. *Prolonged menstruation. * ...
... pruritus) and nose bleeds (epistaxis).[32] Absence of dryness of the lips is considered an indication of non-compliance with ...
Itchiness (pruritus). Pruritus is the primary symptom of cholestasis and is thought to be due to interactions of serum bile ... In fact, the opioid antagonist naltrexone is used to treat pruritus due to cholestasis. Jaundice. Jaundice is an uncommon ... Nalfurafine hydrochloride can also treat pruritus caused by chronic liver disease and was recently approved in Japan for this ... Pruritus in cholestatic jaundice is treated by antihistamines, ursodeoxycholic acid, and phenobarbital. ...
Pruritus List of cutaneous conditions Rapini, Ronald P.; Bolognia, Jean L.; Jorizzo, Joseph L. (2007). Dermatology: 2-Volume ... People burdened with LSC report pruritus, followed by uncontrollable scratching of the same body region, excessively. Most ... Yosipovitch, Gil; Bernhard, Jeffrey D. (2013-04-25). "Chronic Pruritus". New England Journal of Medicine. 368 (17): 1625-1634. ...
Corić-Martinović V, Basić-Jukić N (2008). "[Uremic pruritus]". Acta Medica Croatica. 62 Suppl 1: 32-6. PMID 18578330. Carpenter ... Uremic pruritus Vision changes Vomiting Hypervitaminosis A results from excessive intake of preformed vitamin A. Genetic ...
17 April 1937). "PRURITUS ANI". The Lancet. 229 (5929): 919-922. doi:10.1016/S0140-6736(00)86664-7. ISSN 0140-6736. Ashcraft, K ... "The causes and treatment of pruritus ani". British Medical Journal. 2 (2851): 291-293. 21 August 1915. ISSN 0007-1447. Mummery ...
Pruritus/Itch/. Prurigo. *Lichen simplex chronicus/Prurigo nodularis. *by location: Pruritus ani ...
Pruritus/Itch/. Prurigo. *Lichen simplex chronicus/Prurigo nodularis. *by location: Pruritus ani ...
... pruritus, pain), duration (acute or chronic), arrangement (solitary, generalized, annular, linear), morphology (macules, ...
Pruritus/Itch/. Prurigo. *Lichen simplex chronicus/Prurigo nodularis. *by location: Pruritus ani ...
Pruritus/Itch/. Prurigo. *Lichen simplex chronicus/Prurigo nodularis. *by location: Pruritus ani ...
Pruritus/Itch/. Prurigo. *Lichen simplex chronicus/Prurigo nodularis. *by location: Pruritus ani ...
Pruritus/Itch/. Prurigo. *Lichen simplex chronicus/Prurigo nodularis. *by location: Pruritus ani ...
At ASCO 2007, results from the SHARP trial[13] were presented, which showed efficacy of sorafenib in hepatocellular carcinoma. The primary endpoint was median overall survival, which showed a 44% improvement in patients who received sorafenib compared to placebo (hazard ratio 0.69; 95% CI, 0.55 to 0.87; p=0.0001). Both median survival and time to progression showed 3-month improvements; however, there was no significant difference in median time to symptomatic progression (p=0.77). There was no difference in quality of life measures, possibly attributable to toxicity of sorafenib or symptoms related to underlying progression of liver disease. Of note, this trial only included patients with Child-Pugh Class A (i.e. mildest) cirrhosis.[13] Because of this trial Sorafenib obtained FDA approval for the treatment of advanced hepatocellular carcinoma in November 2007.[4] In a randomized, double-blind, phase II trial combining sorafenib with doxorubicin, the median time to progression was not ...
Pruritus Itching skin; may be a symptom of diabetes. Purified insulins Insulins with much less of the impure proinsulin. It is ...
Pruritus James, William; Berger, Timothy; Elston, Dirk (2005). Andrews' Diseases of the Skin: Clinical Dermatology. (10th ed ...
Itching, rash, pruritus. Suicidal behavior and ideation have been observed as early as one week after starting treatment with ...
Pain; anaesthesia supplement; opioid-induced pruritus.. As per codeine. Respiratory depression is subject to ceiling effect. ... Pruritus (itching) may require switching to a different opioid. Constipation occurs in almost all patients on opioids, and ...
Dermatological disorders: eczema/psoriasis, chronic pruritusEdit. High levels of BDNF and substance P have been found ...
It should relieve pruritus. It should not cause excessive dryness. It should have a wide antibacterial and antifungal spectrum ...
Intense pruritus is characteristic; in patients who present in adolescence, it has been linked with suicide. Patients may have ... with the use of agents to treat cholestasis and pruritus, including the following: Ursodeoxycholic acid Cholestyramine Rifampin ...
Pruritus, which may sometimes precede the onset of FCP, is evident in the affected regions in about half of patients. ... Pruritus is also associated. The etiology of florid cutaneous papillomatosis is unknown. It is likely directly induced by an ... Pruritus is often associated. Florid cutaneous papillomatosis is linked with an underlying cancer. Malignant acanthosis ...
"Itch (Itching or Pruritus)". MedicineNet. Retrieved 3 June 2019. Inui, Shigeki (2015). "Nalfurafine hydrochloride to treat ... Antipruritics, also known as anti-itch drugs, are medications that inhibit the itching (Latin: pruritus) often associated with ... Paus, R. (2006). "Frontiers in pruritus research: scratching the brain for more effective itch therapy". Journal of Clinical ... and are also said to be effective in controlling pruritus in a small number of refractory cases. Mirtazapine, a different type ...
Reamy BV, Bunt CW, Fletcher S (2011). "A diagnostic approach to pruritus". American Family Physician. 84 (2): 195-202. PMID ...
Zachariah JR, Rao AL, Prabha R, Gupta AK, Paul MK, Lamba S (August 2012). "Post burn pruritus--a review of current treatment ... ISBN 978-0-07-154769-7. Goutos I, Dziewulski P, Richardson PM (March-April 2009). "Pruritus in burns: review article". Journal ...
Itch (pruritus) has many causes. Allergies and inflammatory skin disease all produce itch as a symptom. Pathophysiologically, ... Daly BM, Shuster S (1986). "Effect of aspirin on pruritus". BMJ. 293 (6552): 907. doi:10.1136/bmj.293.6552.907. PMC 1341706. ... Greaves MW (1993) Pathophysiology and clinical aspects of pruritus. In: Dermatology in General Medicine. (Fitzpatrick TB, Eisen ... also known as pruritus, is classified as a sensory stimulation to scratch a certain area of the skin. An itch can be a fleeting ...
The main complaint is pruritus. The exact prevalence of food allergy in cats remains unknown. There is no breed, sex or age ...
The most characteristic symptom of infestation is pruritus (itching) on the head which normally intensifies 3 to 4 weeks after ... ISBN 978-953-51-2252-4. Leung AK, Robson LM (May 1, 2008). "Pruritus in Children: What's Itching?". Consultant for ...
Uremic pruritus (also known as uraemic pruritus or renal pruritus[1]) is caused by chronic kidney failure and is the most ... Inui, Shigeki (2015). "Nalfurafine hydrochloride to treat pruritus: a review". Clinical, Cosmetic and Investigational ... Retrieved from "https://en.wikipedia.org/w/index.php?title=Uremic_pruritus&oldid=839888746" ...
... that can show pruritus ani as first symptom. [9] Pruritus scroti Pruritus vulvae Perianal candidiasis James, William; Berger, ... If a specific cause for pruritus ani is found it is classified as "secondary pruritus ani". If a specific cause is NOT found it ... For pruritus ani of unknown cause (idiopathic pruritus ani) treatment typically begins with measures to reduce irritation and ... Pruritus ani is the irritation of the skin at the exit of the rectum, known as the anus, causing the desire to scratch. The ...
Vulval Pruritus. Br Med J 1969; 1 doi: https://doi.org/10.1136/bmj.1.5638.255-c (Published 25 January 1969) Cite this as: Br ...
This book provides a thorough and comprehensive reference in the management of pruritus, designed to be a convenient resource ... Pruritus, Second edition addresses the new concepts and discoveries that have modified our understanding of this condition. It ... Acute and chronic pruritus can represent significant management issues both as a common physiological sensation and as a ... The consequences are that research on this field has been poorer than research on pain and that pruritus is therefore more ...
Brachioradial pruritus is a neurogenic itch syndrome of the upper extremities. It is typically localized to the skin on the ... Waisman M. Solar pruritus of the elbows (brachioradial summer pruritus). Arch Dermatol. 1968 Nov. 98(5):481-5. [Medline]. ... Brachioradial pruritus wanted: a sure cause (and cure) for brachioradial pruritus. Int J Dermatol. 1997 Nov. 36(11):817-8. [ ... Area of pruritus demarcated in pen in a middle-aged woman with brachioradial pruritus. Macroscopically, no skin changes are ...
Itching (pruritus) is a common symptom associated with numerous skin diseases, as well as a secondary symptom of numerous ... 2006. Frontiers in pruritus research: scratching the brain for more effective itch therapy. Journal of Clinical Investigation ... Following evening cannabinoid administration, all three patients reported a decrease in pruritus, as well as "marked ... More recently, Polish researchers reported that application of an endocannabinoid-based topical cream reduced uremic pruritus ...
Broadly, pruritus can be due to a primary dermatological disorder or to an underlying system disease. A wide... ... The impact of pruritus on quality of life: the skin equivalent of pain. Arch Dermatol. 2011;147(10):1153-6.CrossRefPubMedGoogle ... Willans itch and other causes of pruritus in the elderly. Int J Dermatol. 2005;44(4):267-273.CrossRefPubMedGoogle Scholar ... Pruritus of unknown origin: a retrospective study. J Am Acad Dermatol. 2002;45: 892-6.CrossRefGoogle Scholar ...
Correction: Aquagenic pruritus Br Med J (Clin Res Ed) 1981; 283 :505 ... Correction: Aquagenic pruritus. Br Med J (Clin Res Ed) 1981; 283 doi: https://doi.org/10.1136/bmj.283.6289.505-b (Published 15 ...
Treatment measures for pruritus include the following{ref164}: Moisturizers Histamine 1 (H1) and histamine 2 (H2) blockers ... encoded search term (How is pruritus treated in scleroderma?) and How is pruritus treated in scleroderma? What to Read Next on ... How is pruritus treated in scleroderma?. Updated: Nov 13, 2018 * Author: Sergio A Jimenez, MD, MACR, FACP, FRCP(UK Hon); Chief ...
... itch or pruritus). Get relief with home remedies for itchy skin. Dry skin, fungus, sunburn, and bites may cause itching. ... Itch (Itching or Pruritus). Facts Symptoms/Signs Causes Diagnosis Specialists Should You Scratch? Treatment Remedies ... Pruritus can be caused by many conditions. Stress, anxiety, or other emotional problems can cause itching. Stress also can ... Itch (Itching or Pruritus) Browse through our medical image collection to see pictures of the most common, and uncommon, skin ...
... itch or pruritus). Get relief with home remedies for itchy skin. Dry skin, fungus, sunburn, and bites may cause itching. ... Pruritus can be caused by many conditions. Stress, anxiety, or other emotional problems can cause itching. Stress also can ... Itch (Itching or Pruritus) Browse through our medical image collection to see pictures of the most common, and uncommon, skin ... When pruritus is caused by irritations of other sorts (insect bites, for instance), hydrocortisone doesnt help much at all. If ...
Pruritus) zu erleichtern, ist eine schwierige Aufgabe der pädiatrischen Dermatologie, ist es doch das Hauptsymptom der ... Chronic pruritus in atopic dermatitis. Abstract. To relieve the sensation of itch (pruritus) is one of the most difficult tasks ... Pruritus Gehirn-Haut-Interaktion Pruritus und seine Weiterleitung Einflussmöglichkeiten und Hindernisse Atopische Dermatitis ... Szepietowski JC, Reich A, Wisnicka B (2004) Pruritus and psoriasis. Br J Dermatol 151(6):1284CrossRefPubMedGoogle Scholar ...
Whether these mechanisms are involved in pruritus accompanying LP requires further investigation. Limited knowledge of pruritus ... T. Liu, Z.-Z. Xu, C.-K. Park, T. Berta, and R.-R. Ji, "Toll-like receptor 7 mediates pruritus," Nature Neuroscience, vol. 13, ... It was supposed that activation of μ-opioid receptors induces pruritus, while activation of -opioid receptors exerts an ... H. L. Tey and G. Yosipovitch, "Targeted treatment of pruritus: a look into the future," British Journal of Dermatology, vol. ...
Epidemiologic Notes and Reports Mucuna pruriens- Associated Pruritus -- New Jersey On October 6, 1985, a Paterson, New Jersey, ... Soon after their arrival, the EMTs developed pruritus. All four individuals went to an emergency room complaining of itching ... Fire Department ambulance responded to a call reporting two people with severe pruritus. On arrival, the two emergency medical ...
Management of nonspecific pruritus is directed mostly at preventing xerosis. Management of disease-specific pruritus has been ... Effective treatment of pruritus can prevent scratch-induced complications such as lichen simplex chronicus and impetigo. ... Causes of systemic pruritus include uremia, cholestasis, polycythemia vera, Hodgkins lymphoma, hyperthyroidism, and human ... Patients, particularly elderly adults, with severe pruritus that does not respond to conservative therapy should be evaluated ...
... , Perianal Pruritus, Anal Pruritus, Perianal Dermatitis. ... Pruritus ani, Anal itch, Perianal itch, Pruritus ani (disorder), itch; anal, pruritus; ani, anal; itch, ani; pruritus, Pruritus ... PRURITUS ANI, pruritus ani (diagnosis), anal itching, pruritus ani, anal itching (symptom), rectal pruritus, anal pruritus, ... pruritus aan bilnaad, pruritus ani, perianale jeuk, anale pruritus, perianale irritatie, anaal; jeuk, ani; pruritus, jeuk; ...
... "mild pruritus," "moderate pruritus," "severe pruritus," and "very severe pruritus." All pregnant women with pruritus were asked ... The point prevalence of pruritus was 20.2% (. ), while pruritus prevalence during the entire pregnancy was 38.0% (. ). Pruritus ... Characteristic of Pruritus. Pruritus on average started at WoG. In most pregnant women, it started after the 25th WoG, although ... Pruritus Severity and Quality of Life Impairment. The mean intensity of pruritus measured with VAS was points ranging from 0.6 ...
... itch or pruritus). Get relief with home remedies for itchy skin. Dry skin, fungus, sunburn, and bites may cause itching. ... Pruritus can be caused by many conditions. Stress, anxiety, or other emotional problems can cause itching. Stress also can ... When pruritus is caused by irritations of other sorts (insect bites, for instance), hydrocortisone doesnt help much at all. If ... Brachioradial pruritus is a neurologic condition that results in intense itching of the arms. It usually develops on the ...
Pruitus ani (anal itching) is a skin condition around the anus that can affect both men and women at any age. Factors such as faeces or mucus from the anus irritate the surrounding skin, which causes itching. Scratching can further damage the skin.
Treatment of Pruritus in Dogs. The key to relief from pruritus is to identify and treat the underlying cause. Pruritus may be ... How pruritus affects your dogs health depends on the degree of the pruritus. Mild pruritus may hardly have any effect at all. ... Diagnosis of Pruritus in Dogs. Diagnostic tests may be needed to determine the cause of the pruritus. Your veterinarian will ... Many skin diseases can cause or can contribute to pruritus. Every dog has a threshold of pruritus. When the nerves of the skin ...
Among the diseases that can cause pruritus are renal insufficiency, cholestasis, Hodgkins lymphoma, polycythemia vera, solid ... Understanding pruritus in systemic disease J Pain Symptom Manage. 2001 Feb;21(2):151-68. doi: 10.1016/s0885-3924(00)00256-6. ... Other pruritic conditions appear to be iatrogenic; opioid-induced pruritus may be the most important in palliative medicine. ... Among the diseases that can cause pruritus are renal insufficiency, cholestasis, Hodgkins lymphoma, polycythemia vera, solid ...
The condition, aquagenic pruritus, causes a severe itching sensation immediately after water of any temperature touches the ... Aquagenic pruritus may make daily hygiene a challenge, but the right medication and clothing choices can minimise allergic ... The condition, aquagenic pruritus, causes a severe itching sensation immediately after water of any temperature touches the ... Ask your doctor for recommendations on how to treat your aquagenic pruritus. A doctors assessment is important, because the ...
Helping you find trustworthy answers on Pruritus in Pregnancy , Latest evidence made easy ... Find all the evidence you need on Pruritus in Pregnancy via the Trip Database. ... The pruritus persists and worsens as the pregnancy continues and resolves within 48 hours of delivery. The pruritus is often ... pruritus and raised levels of serum bile acids) or pruritus and raised alanine transaminase levels (>100 IU/L) recruited after ...
Pruritus scroti is itchiness of the scrotum that may be secondary to an infectious cause. Pruritus vulvae Pruritus ani Pruritus ...
Pruritus vulvae is itchiness of the vulva, which is the counterpart of pruritus scroti, and may have many different causes. ... ISBN 0-7216-2921-0. Utaş S, Ferahbaş A, Yildiz S (2008). "Patients with vulval pruritus: patch test results". Contact ...
Prevalence and characterization of uremic pruritus in patients undergoing hemodialysis: uremic pruritus is still a major ... ABSTRACT: Uremic pruritus (UP) is a common complication in patients with chronic kidney disease. Although the etiology of UP is ... Uremic Pruritus Review. Muideen Adigun, PharmD, BCPS, BCPP. Program Director, PGY-1 Pharmacy Practice Residency. Howard ... of patients with severe pruritus at baseline experienced reduction of symptoms to weak pruritus and 40% experienced reduction ...
... , Pregnancy Related Pruritus, Pruritus gravidarum, Prurigo gravidarum. ... Pruritus in Pregnancy. Pruritus in Pregnancy Aka: Pruritus in Pregnancy, Pregnancy Related Pruritus, Pruritus gravidarum, ... These images are a random sampling from a Bing search on the term "Pruritus in Pregnancy." Click on the image (or right click) ... Intrahepatic Cholestasis of Pregnancy Pruritus Causes Pruritic Urticarial Papules and Plaques of Pregnancy Skin Conditions of ...
The term scleroderma is derived from the Greek words skleros (hard or indurated) and derma (skin) and it is used to describe a disease characterized by progressive skin hardening and induration. Hippocrates first described this condition as thickened skin.
... pruritus) - Comprehensive overview of this common irritating skin condition covers causes, treatment and self-care measures. ... Chronic pruritus in the absence of specific skin disease. American Journal of Clinical Dermatology. 2010;11:399. ... Pathophysiology and clinical aspects of pruritus. In: Fitzpatricks Dermatology in General Medicine. 8th ed. New York, N.Y.: ... Some people with long-term pruritus say that a hot shower eases their symptoms for hours. Others say a cold shower helps. ...
Pruritus can be a consequence of tumour growth, a complication of treatment, secondary to cholestasis, or caused by brain ... The first two complications are discussed in detail, as are how to recognize patterns and treat pruritus caused by cancer. ... Paroxetine is considered to be the drug of choice for symptomatic treatment of pruritus-complicating cancer. ... This chapter discusses pruritus that accompanies solid tumours. This is considered to be an uncommon symptom, but it can ...
  • Some authorities describe "psychogenic pruritus" or "functional itch disorder", where psychological factors may contribute to awareness of itching. (wikipedia.org)
  • This book provides a thorough and comprehensive reference in the management of pruritus, designed to be a convenient resource for all physicians confronted with patients suffering from itch. (springer.com)
  • Brachioradial pruritus is a neurogenic itch syndrome of the upper extremities. (medscape.com)
  • 2006 . Frontiers in pruritus research: scratching the brain for more effective itch therapy . (norml.org)
  • Willan's itch and other causes of pruritus in the elderly. (springer.com)
  • Zachariae R, Lein U, Haedersdal M, Zachariae C. Itch severity and quality of life in patients with pruritus: preliminary validity of a Danish adaptation of the itch severity scale. (springer.com)
  • To relieve the sensation of itch (pruritus) is one of the most difficult tasks of pediatric dermatology as pruritus occurs as a major symptom of atopic dermatitis. (springer.com)
  • Itch or pruritus is a cutaneous sensation different from pain. (hindawi.com)
  • It is possible that these changes may alter the pruritus pathway and contribute to itch in susceptible individuals [ 6 ]. (hindawi.com)
  • In 2007, the International Forum for the Study of Itch (IFSI) established a new classification of chronic itch which allows physicians to assign all patients with pruritus to one of three groups including subjects with pruritus on diseased (inflamed) skin (group I), those having pruritus on nondiseased (noninflamed) skin (group II), and individuals with chronic secondary lesions (group III). (hindawi.com)
  • Every dog has a threshold of pruritus or an "itch threshold. (petplace.com)
  • Pruritus vulvae is the medical term for a persistent, uncomfortable itch on and around the vulva. (wisegeek.com)
  • This issue of Dermatologic Clinics, guest edited by Dr. Gil Yosipovitch, is devoted to Pruritus (Itch). (elsevier.com)
  • Anal itch, also known as pruritus ani, is an irritating, itchy sensation around the anus (the opening through which stool passes out of the body). (drugs.com)
  • In contrast to conditions, such as urticaria, in which histamine primarily drives itch (pruritus), cholestatic pruritus is multifactorial and more difficult to treat. (nih.gov)
  • Many studies have shown gabapentin to be effective in the case of brachioradial pruritus, itch of neuropathic in origin, uremic pruritus, multiple sclerosis-induced pruritus,cholestatic pruritus, itch produced by burn, and pruritus of unknown origin. (clinicaltrials.gov)
  • Once chronic pruritus has occurred, there may be secondary changes in the nerves in the skin and central nervous system which heighten the sensation of itch. (dermnetnz.org)
  • Pruritus Ani is an itch localized to the anus and perennial skin. (hpathy.com)
  • For patients undergoing hemodialysis who have moderate-to-severe pruritus, difelikefalin is associated with a significant reduction in itch intensity and improvement in itch-related quality of life, according to a study published online Nov. 8 in the New England Journal of Medicine . (doctorslounge.com)
  • Treatment with difelikefalin for 12 weeks resulted in a marked and rapid reduction in itch intensity among patients undergoing hemodialysis who had chronic kidney disease-associated pruritus," the authors write. (doctorslounge.com)
  • Pruritus, or itch, is defined as an unpleasant sensation that provokes the desire to scratch. (medgadget.com)
  • Even scratching at an itch, itself, can add to inflammation and pruritus in dogs. (dogtime.com)
  • The International Forum for the Study of Itch (IFSI) has proposed three categories of pruritus skin conditions, i.e. pruritus on normal skin, inflamed skin, or with chronic secondary scratch lesions. (transparencymarketresearch.com)
  • The dose of Oral KORSUVA (1 mg BID) in the Phase 2 trial is based on comparison to the exposure levels achieved with 0.5 mcg/kg dose of I.V. KORSUVA that exhibited statistically significant and clinically meaningful reduction in itch intensity in hemodialysis patients with moderate-to-severe pruritus in the Phase 2 and 3 trials. (yahoo.com)
  • Treatment with difelikefalin (DFK), an investigational medication, is associated with rapid and sustained itch reduction and improvement in itch-related quality of life among patients on hemodialysis suffering from moderate to severe chronic kidney disease (CKD)-associated pruritus, according to phase 3 study results presented at the American Society of Nephrology's Kidney Week 2020 Reimagined virtual conference. (renalandurologynews.com)
  • The median baseline disease-severity scores among the full patient population were 75.4 for the pruritus visual-analog scale score, 3 for the score on the five-level itch scale, and 23.2 for the Eczema Area and Severity Index score. (consultantlive.com)
  • Uremic pruritus (also known as uraemic pruritus or renal pruritus [1] ) is caused by chronic kidney failure and is the most common internal systemic cause of itching . (wikipedia.org)
  • More recently, Polish researchers reported that application of an endocannabinoid-based topical cream reduced uremic pruritus and xerosis (abnormal dryness of the skin) in hemodialysis patients. (norml.org)
  • 2005. Efficacy and tolerance of the cream containing structured physiological lipid endocannabinoids in the treatment of uremic pruritus: a preliminary study . (norml.org)
  • ABSTRACT: Uremic pruritus (UP) is a common complication in patients with chronic kidney disease. (uspharmacist.com)
  • Uremic pruritus or chronic kidney disease-associated pruritus (CKD-aP) remains a frequent and compromising symptom in patients with advanced or end-stage renal disease, strongly reducing the patient's quality of life. (wellnessresources.com)
  • Uremic pruritus: roles of parathyroid hormone and substance P. J Am Acad Dermatol . (medscape.com)
  • To investigate the efficacy and the safety of pregabalin, as compared with fexofenadine and placebo, in the treatment of uremic pruritus. (clinicaltrials.gov)
  • Gabapentin - A Solution to Uremic Pruritus? (bioportfolio.com)
  • Severe uremic pruritus among hemodialysis (HD) patients is slowly decreasing in prevalence, but the condition is still underestimated and undertreated, according to researchers. (renalandurologynews.com)
  • Although uremic pruritus (UP) is a common and annoying symptom for end-stage renal disease patients on hemodialysis (HD) and peritoneal dialysis, its pathogenesis is poorly understood. (dovepress.com)
  • Moreover, there are various underlying etiologies for pruritus, for instance hepatogenic pruritus results from hepatitis&jaundice, uremic pruritus results from chronic kidney diseases and dialysis, and some forms are drug-induced pruritus. (transparencymarketresearch.com)
  • citation needed] In case of long-lasting symptoms, above all in patients over 50 years of age, a colonoscopy is useful to rule out a colonic polyp or tumor, that can show pruritus ani as first symptom. (wikipedia.org)
  • What are associated symptoms and signs of itching (pruritus)? (medicinenet.com)
  • The antihistamine should prevent or minimise aquagenic pruritus symptoms. (ehow.co.uk)
  • Some people with long-term pruritus say that a hot shower eases their symptoms for hours. (mayoclinic.org)
  • Home remedies and over-the-counter products are usually successful at treating minor pruritus vulvae symptoms. (wisegeek.com)
  • Based on the neuropathic hypothesis and frequent co-occurrence of chronic pruritus and peripheral neuropathy in the patients undergoing hemodialysis, gabapentin, a medication widely used for a spectrum of neuropathic pain syndromes, has recently been suggested to be effective in the treatment of UP.Pregabalin, another gabaergic drug structurally related to gabapentin, have an advantage over gabapentin in terms of its more rapid response to stressful symptoms. (clinicaltrials.gov)
  • Information about pruritus ani symptoms, causes, pruritus ani treatment with homeopathy medicine or homeopathic treatment for pruritus ani. (hpathy.com)
  • The close relationship between pathways for pain and pruritus may result in severe and unusual symptoms. (ebscohost.com)
  • If you have severe or persistent symptoms of itching, especially generalized pruritus, see your doctor for appropriate evaluation and treatment. (verywellhealth.com)
  • Among patients always or nearly always bothered by itchy skin, 17% did not report their symptoms to a health care provider and 18% used no treatment for pruritus. (renalandurologynews.com)
  • Here's what you should know about the symptoms, causes, and treatments for pruritus in dogs. (dogtime.com)
  • Steven Fishbane, M.D., from Donald and Barbara Zucker School of Medicine at Hofstra-Northwell in Great Neck, New York, and colleagues conducted a randomized, double-blind phase 3 trial in which 378 patients undergoing hemodialysis with moderate-to-severe pruritus were randomly assigned to receive either intravenous difelikefalin or placebo three times per week for 12 weeks (158 and 165 patients, respectively). (doctorslounge.com)
  • The Phase 2 multicenter, randomized, double-blind, placebo-controlled 16-week trial is designed to evaluate the safety and efficacy of 1 mg tablet of Oral KORSUVA taken twice daily (BID) versus placebo in approximately 60 patients with PBC and moderate-to-severe pruritus. (yahoo.com)
  • The U.S. Food and Drug Administration (FDA) has granted Breakthrough Therapy designation to I.V. CR845 for the treatment of moderate-to-severe pruritus in CKD patients undergoing hemodialysis. (yahoo.com)
  • 2 In that trial, investigators randomly assigned 378 patients on HD who had moderate to severe pruritus to receive DFK 0.5 mcg/kg or placebo. (renalandurologynews.com)
  • They aimed to evaluate nemolizumab administered concomitantly with topical agents in Japanese patients with atopic dermatitis and inadequately controlled moderate-to-severe pruritus. (consultantlive.com)
  • A wide variety of systemic diseases is associated with pruritus, and in 10-50%, it is an important intimation of an underlying system disease. (springer.com)
  • Patients, particularly elderly adults, with severe pruritus that does not respond to conservative therapy should be evaluated for an underlying systemic disease. (aafp.org)
  • Management of disease-specific pruritus has been established for certain systemic conditions, including uremia and cholestasis. (aafp.org)
  • While pruritus most commonly occurs in skin disorders, it may be an important dermatologic clue to the presence of an underlying systemic disease. (aafp.org)
  • Tarikci N, Kocatürk E, Güngör Ş, Topal IO, Can PÜ, Singer R. Pruritus in Systemic Diseases: A Review of Etiological Factors and New Treatment Modalities. (medscape.com)
  • Pruritus is often a symptom of an underlying disease process such as a skin problem, a systemic disease, or abnormal nerve impulses. (dermnetnz.org)
  • Systemic diseases may cause generalised pruritus. (dermnetnz.org)
  • Secondary pruritus due to underlying systemic disorder (secondary pruritus). (nursinginpractice.com)
  • More directed management can be divided into topical treatments, systemic treatments, phototherapy, psychological approaches or alternative therapies and should be based on the pruritus classifications cited within the latest guidance. (nursinginpractice.com)
  • Clinical Characteristics of Pruritus in Systemic Sclerosis Vary According to the Autoimmune Subtype. (bioportfolio.com)
  • Pruritus is a frequent symptom in systemic sclerosis (SSc), with a prevalence of 40-65%, but its pathophysiology is poorly understood. (bioportfolio.com)
  • Pruritus may be caused by a local reaction in the skin (localized pruritus) or a systemic disease that triggers widespread itchiness (generalized pruritus). (verywellhealth.com)
  • The best treatment of pruritus is to fix the underlying cause of the itching, whether that is a skin condition or a systemic disease. (verywellhealth.com)
  • The diagnosis of the actual cause of pruritus requires a meticulous assessment involving clinical examination and laboratory investigations, which may be dermatologic, systemic, neurogenic, and psychogenic in nature. (transparencymarketresearch.com)
  • It is estimated that pruritus is a manifestation of an underlying systemic disease in approximately 10% to 25% of affected individuals. (peacehealth.org)
  • The Editors have recruited a board of internationally renowned experts to provide an in-depth analysis of the causes and management of pruritus, including the current concepts in pathophysiology and novel therapeutics. (springer.com)
  • The purpose is to provide a comprehensive resource on all aspects of pruritus (etiology, pathophysiology, neural pathways, and medications). (springer.com)
  • The pathophysiology of chronic pruritus is very complex although recent research and scientific knowledge on the different triggers of pruritus and on the possible therapeutic influences lead us to the point where patients will-besides anti-inflammatory ointments-benefit from a wider range of treatments, e.g. (springer.com)
  • Although these new therapies show promise, further research is needed to confirm the pathophysiology of cholestatic pruritus so that targeted therapy can be developed. (nih.gov)
  • Pathophysiology of opioid-induced pruritus remain unclear and more than one mechanism may be involved in the development of opioid-induced pruritus, such as, mediated central µ opioid receptors, Dopamine (D2) receptors, Serotonin (5-HT3) receptors, prostaglandin system, GABA receptors, and glycine receptors, so that why opioid-induced pruritus is difficult to manage. (clinicaltrials.gov)
  • This article reviews the etiologies, pathophysiology, clinical evaluation, and treatment of idiopathic pruritus ani and perianal dermatitis. (medworm.com)
  • What is brachioradial pruritus? (medscape.com)
  • Heyl T. Brachioradial pruritus. (medscape.com)
  • Medical pearl: the ice-pack sign in brachioradial pruritus. (medscape.com)
  • Waisman M. Solar pruritus of the elbows (brachioradial summer pruritus). (medscape.com)
  • Brachioradial pruritus: a tropical dermopathy. (medscape.com)
  • Brachioradial Pruritus. (medscape.com)
  • Crevits L. Brachioradial pruritus--a peculiar neuropathic disorder. (medscape.com)
  • Brachioradial pruritus wanted: a sure cause (and cure) for brachioradial pruritus. (medscape.com)
  • A case of neuropathic brachioradial pruritus caused by cervical disc herniation. (medscape.com)
  • Wallengren J, Sundler F. Brachioradial pruritus is associated with a reduction in cutaneous innervation that normalizes during the symptom-free remissions. (medscape.com)
  • Wallengren J. Self-healing photo-neuropathy and cervical spinal arthrosis in four sisters with brachioradial pruritus. (medscape.com)
  • De Ridder D, Hans G, Pals P, Menovsky T. A C-fiber-mediated neuropathic brachioradial pruritus. (medscape.com)
  • Wallengren J, Dahlbäck K. Familial brachioradial pruritus. (medscape.com)
  • Brachioradial pruritus--an uncommon photodermatosis presenting in a temperate climate. (medscape.com)
  • Brachioradial pruritus -- descriptive analysis of Brazilian case series. (medscape.com)
  • Photoallergic reactions to varenicline mimicking brachioradial pruritus. (medscape.com)
  • Barry R, Rogers S. Brachioradial pruritus--an enigmatic entity. (medscape.com)
  • Brachioradial pruritus: cervical spine disease and neurogenic/neuropathic [corrected] pruritus. (medscape.com)
  • Brachioradial pruritus as a result of cervical spine pathology: the results of a magnetic resonance tomography study. (medscape.com)
  • Brachioradial pruritus is an uncommon condition that presents as lateral arm pruritus and has been associated with spinal disease. (aafp.org)
  • Data from patients with brachioradial pruritus, who reported starting treatments within the last 5 years. (patientslikeme.com)
  • Gabapentin has been shown to be effective for the treatment of pruritus in adult patients with brachioradial pruritus, uraemic pruritus and pruritus of unknown origin. (bioportfolio.com)
  • Itching ( pruritus ) is a common symptom associated with numerous skin diseases, as well as a secondary symptom of numerous serious conditions such as renal failure and liver disease. (norml.org)
  • [6] Three weeks of twice-daily application of the cream "completely eliminated" pruritus in 38 percent of trial subjects and "significantly reduced" itching in others. (norml.org)
  • The medical term for itching is pruritus . (medicinenet.com)
  • In medical terminology, itching is known as pruritus . (medicinenet.com)
  • If your dog spends a large portion of his time scratching, he may have a condition known as pruritus, or itching, an unpleasant sensation that causes your dog to scratch or bite at himself. (petplace.com)
  • Pruritus may be temporarily relieved with medication but the itching often recurs after the medication is finished. (petplace.com)
  • The condition, aquagenic pruritus, causes a severe itching sensation immediately after water of any temperature touches the skin. (ehow.co.uk)
  • In most cases, frequent or constant itching is the only symptom of pruritus vulvae. (wisegeek.com)
  • Topical anti-inflammatory creams may help alleviate the itching associated with pruritus vulvae. (wisegeek.com)
  • Itching (pruritus) is an unpleasant sensation causing you to respond by scratching. (nuffieldhealth.com)
  • Anal pruritus, an intense chronic itching affecting the perianal skin, is a common condition. (racgp.org.au)
  • Treatment for pruritus vulvae may include warm baths, gentle cleansing of the vulva, corticosteroid creams or lotions, and oral antihistamines for itching . (freemd.com)
  • The key symptom of Pruritus Ani is perianal itching or burning after bowel movement, during stress, or at night. (hpathy.com)
  • Pruritus ani is a bothersome and sometimes intense itching or burning sensation of the skin around the anus (rectal opening). (susquehannahealth.org)
  • Pruritus is a chronic itching condition caused due to dermatological disease including atopic dermatitis, contact dermatitis, mycoses, chickenpox etc. (sbwire.com)
  • Pruritus: itching and scratching. (thebeefsite.com)
  • Pruritus ani is the term used for intense and protracted itching in the perianal area (an area of exquisite sensitivity). (visualdx.com)
  • Anal itching is also known as Pruritus ani . (organicfacts.net)
  • Pruritus simply means itching. (uctv.tv)
  • Agents, usually topical, that relieve itching (pruritus). (bioportfolio.com)
  • Pruritus refers to an unpleasant sensation that causes the need to scratch, commonly called itching by most people. (verywellhealth.com)
  • Pruritus ani is a chronic itching of the skin around the anus. (digitalnaturopath.com)
  • Pruritus sometimes feels like pain because the signals for itching and pain travel along the same nerve pathways. (peacehealth.org)
  • Finding the cause of the itching is the first step in relieving pruritus. (peacehealth.org)
  • Treatment for pruritus in dogs depends on the cause, but the main goals are to reduce itching and remove the source of irritation from the skin. (dogtime.com)
  • This process results in the form of pruritus or itching. (transparencymarketresearch.com)
  • The aim of this study was to investigate the prevalence, clinical characteristics, and the importance of pruritus in pregnant women. (hindawi.com)
  • Thus, pruritus therapeutics market is mainly driven by increasing the prevalence of atopic dermatitis. (mynewsdesk.com)
  • Although some studies suggested pruritus is being decreased recently by use of better dialysis techniques, accumulating studies have shown the still high prevalence of UP. (clinicaltrials.gov)
  • Growing prevalence of diseases like atopic dermatitis, allergic contact dermatitis and urticaria around the world is expected to drive pruritus therapeutics market. (sbwire.com)
  • Increasing global prevalence of atopic dermatitis, allergic contact dermatitis and urticaria is expected to drive the pruritus therapeutics market over the forecast period. (sbwire.com)
  • The global demand for pruritus therapeutics increases due to high prevalence of dermatological disorders. (sbwire.com)
  • Medical directors underestimated the prevalence of pruritus in 69% of facilities, according to the investigators. (renalandurologynews.com)
  • In many facilities, where 21% to 50% of patients reported having severe pruritus , only 1% of medical directors estimated the same prevalence of pruritus in their facility. (renalandurologynews.com)
  • International comparisons of prevalence, awareness, and treatment of pruritus in people on hemodialysis. (renalandurologynews.com)
  • Prevalence, correlates and characteristics of chronic pruritus: a population-based cross-sectional s. (biomedsearch.com)
  • Geographically, there is a global demand for pruritus therapeutics, which is on the rise due to high prevalence of dermatological disorders. (transparencymarketresearch.com)
  • Pruritus is a common symptom of cholestatic liver diseases with a prevalence of up to 70 percent in patients with PBC. (yahoo.com)
  • Prevalence of pruritus in patients with chronic liver disease: A multicenter study. (yahoo.com)
  • Pruritus, or itchy skin , is one of the most common skin complaints of older adults. (healthcommunities.com)
  • Both types of pruritus with no underlying dermatosis may have secondary skin changes due to scratching and rubbing such as excoriations (scratches), lichenification (skin thickening) and nodular prurigo (itchy nodules or bumps). (nursinginpractice.com)
  • Answer Although most cases of pruritus can be attributed to itchy dry skin, there are conditions unique to pregnancy that involve pruritus as a leading symptom. (cfp.ca)
  • Pruritus is an itchy feeling that makes you want to scratch your skin. (peacehealth.org)
  • When the pruritus started, how long it lasts, how bad it is, and what part of your body is itchy. (peacehealth.org)
  • For pruritus ani of unknown cause (idiopathic pruritus ani) treatment typically begins with measures to reduce irritation and trauma to the perianal area. (wikipedia.org)
  • A successful treatment option for chronic idiopathic pruritus ani has been documented using a clean, dry and apply (if necessary) methodology. (wikipedia.org)
  • Certain idiopathic types of localized pruritus have been attributed to peripheral neuropathy. (aafp.org)
  • Pruritus Ani is categorized as either idiopathic (primary) or secondary. (hpathy.com)
  • Idiopathic Pruritus Ani is diagnosed when no underlying etiology is found. (hpathy.com)
  • Long-term follow-up of intradermal injection of methylene blue for intractable, idiopathic pruritus ani. (annals.org)
  • However, lack of awareness about pruritus may hamper the growth of pruritus therapeutics market. (mynewsdesk.com)
  • However, lack of awareness of the root cause of pruritus and a universally accepted therapy for pruritus is expected to hamper growth of pruritus therapeutics industry. (sbwire.com)
  • Some of these factors can offset the growth of pruritus therapeutics in the market.The key opportunities in the pruritus therapeutics market include new discoveries such as the identification of new T-cell subsets (Th17 & Th22), and patent expiry of various pruritus therapeutic drugs such as Protopic (tacrolimus). (transparencymarketresearch.com)
  • These factors will provide a platform for new players in the market to capitalize such avenues in the pruritus therapeutics market.Therefore, it is anticipated that these lucrative opportunities could contribute to the growth of pruritus therapeutics in future. (transparencymarketresearch.com)
  • On October 6, 1985, a Paterson, New Jersey, Fire Department ambulance responded to a call reporting two people with severe pruritus. (cdc.gov)
  • Severe pruritus also has been observed in patients with spinal tumors and multiple sclerosis. (aafp.org)
  • However, severe pruritus leads to intense scratching, which may result in painful skin lesions that may become infected. (petplace.com)
  • Studies have shown that patients with severe pruritus are male and have a high predialysis concentration of blood urea nitrogen, hypercalcemia, hyperphosphatemia, secondary hyperparathyroidism, and hypermagnesemia. (uspharmacist.com)
  • 8 However, not all patients with severe hyperparathyroidism have pruritus. (uspharmacist.com)
  • Patients of this disease experience severe pruritus and clinically acute, lichenified eczematous lesions. (ebscohost.com)
  • Although the size of the burn injury is a risk factor for pruritus, almost 50% of patients with small burn injuries reported moderate or severe pruritus. (bioportfolio.com)
  • The majority of medical directors (65%) of dialysis facilities, however, estimated that less than 5% of their patients suffered from severe pruritus, Dr Rayner and colleagues reported online ahead of print in the Clinical Journal of the American Society of Nephrology . (renalandurologynews.com)
  • Medical directors ranked 5 therapeutic options for patients with severe pruritus in order of importance. (renalandurologynews.com)
  • These conditions are associated with severe pruritus and some might be associated with adverse fetal outcomes. (cfp.ca)
  • 1 , 2 Pruritus can be sufficiently severe to affect sleep and quality of life, and might lead to or worsen depression. (cfp.ca)
  • The patients had moderate to severe CKD-associated pruritus. (renalandurologynews.com)
  • The patient complains of a very severe pruritus, not as a rule continuous, but at intervals. (annals.org)
  • Aquagenic pruritus may make daily hygiene a challenge, but the right medication and clothing choices can minimise allergic reactions. (ehow.co.uk)
  • Ask your doctor for recommendations on how to treat your aquagenic pruritus. (ehow.co.uk)
  • Filtered ultraviolet-B phototherapy treatments can help a aquagenic pruritus patient build a resistance to allergic reactions. (ehow.co.uk)
  • Description of the characteristics of aquagenic pruritus expressed by patients suffering from myeloproliferative neoplasms. (clinicaltrials.gov)
  • Distribution of the questionnaire to each patients with myeloproliferative neoplasms (treated or not) suffering from aquagenic pruritus. (clinicaltrials.gov)
  • Analyse of each characteristic of the aquagenic pruritus by a statistician and publication at the end. (clinicaltrials.gov)
  • In some instances, however, pruritus vulvae can be a sign of a more serious underlying condition, such as a sexually transmitted disease or a yeast infection. (wisegeek.com)
  • Many factors can contribute to pruritus vulvae, including poor hygiene practices, using scented soaps or cleansers, and wearing tight underwear made from synthetic materials. (wisegeek.com)
  • Pruritus vulvae may make sexual intercourse painful. (wisegeek.com)
  • A gynecologist can advise on pruritus vulvae. (wisegeek.com)
  • Relatively mild instances of pruritus vulvae tend to respond well to home treatments. (wisegeek.com)
  • Pruritus vulvae may be caused by an allergic reaction to some laundry detergents. (wisegeek.com)
  • With treatment and follow-up preventive care, most cases of pruritus vulvae can be cured. (wisegeek.com)
  • Pruritus vulvae may be a sign of a sexually transmitted disease. (wisegeek.com)
  • Painful urination may occur as a result of pruritus vulvae. (wisegeek.com)
  • Scented feminine hygiene products are a common cause of pruritus vulvae. (wisegeek.com)
  • To help prevent or treat pruritus vulvae, women should wear loose-fitting cotton underwear to reduce friction and sweating in the genital area. (wisegeek.com)
  • The treatment for pruritus vulvae depends on the cause. (freemd.com)
  • Pruritus vulvae in prepubertal children. (freemd.com)
  • Vulvar dermatoses and pruritus vulvae. (freemd.com)
  • Pruritus Ani and Pruritus Vulvae of Fungal Origin. (annals.org)
  • Pruritus ani and vulvae are two of the most annoying and obstinate conditions with which the general practitioner comes into contact, and his therapeutic attempts are usually unsuccessful. (annals.org)
  • Pruritus - Pipeline Review, H1 2017, provides an overview of the Pruritus (Dermatology) pipeline landscape. (medgadget.com)
  • Global Markets Direct's Pharmaceutical and Healthcare latest pipeline guide Pruritus - Pipeline Review, H1 2017, provides comprehensive information on the therapeutics under development for Pruritus (Dermatology), complete with analysis by stage of development, drug target, mechanism of action (MoA), route of administration (RoA) and molecule type. (medgadget.com)
  • Clinical aspects of pruritus in Dermatology in General Medicine. (springer.com)
  • An estimated 2% of all dermatology visits are for pruritus , "but it's probably more than that, because a lot of those complaints don't come up until you ask the patient in person," he said. (thefreedictionary.com)
  • Even though pruritus , xeroderma, eczema and being prone to bruising are amongst the most common manifestations observed in dermatology clinics, tumours, whether malignant or benign, tend to be more evident than inflammatory conditions [2]. (thefreedictionary.com)
  • The Pruritus (Dermatology) pipeline guide also reviews of key players involved in therapeutic development for Pruritus and features dormant and discontinued projects. (medgadget.com)
  • Pruritus (Dermatology) pipeline guide helps in identifying and tracking emerging players in the market and their portfolios, enhances decision making capabilities and helps to create effective counter strategies to gain competitive advantage. (medgadget.com)
  • The pipeline guide provides a snapshot of the global therapeutic landscape of Pruritus (Dermatology). (medgadget.com)
  • The pipeline guide reviews pipeline therapeutics for Pruritus (Dermatology) by companies and universities/research institutes based on information derived from company and industry-specific sources. (medgadget.com)
  • The pipeline guide reviews key companies involved in Pruritus (Dermatology) therapeutics and enlists all their major and minor projects. (medgadget.com)
  • The pipeline guide evaluates Pruritus (Dermatology) therapeutics based on mechanism of action (MoA), drug target, route of administration (RoA) and molecule type. (medgadget.com)
  • Find and recognize significant and varied types of therapeutics under development for Pruritus (Dermatology). (medgadget.com)
  • Formulate corrective measures for pipeline projects by understanding Pruritus (Dermatology) pipeline depth and focus of Indication therapeutics. (medgadget.com)
  • Chronic pruritus, which is associated with a wide variety of underlying diseases, represents a challenge in diagnostics and treatment in dermatology and general medicine. (biomedsearch.com)
  • Department of Dermatology and Competence Center Chronic Pruritus, University Hospital, DE-48149 Münster, Germany. (biomedsearch.com)
  • Additional endpoints included the time course of percent change in the daily visual-analog scale score for pruritus up to week 4, the percent change in the Eczema Area and Severity score from baseline to week 16, and the percentage of patients with a score of 4 or less on the total Dermatology Life Quality Index. (consultantlive.com)
  • STAMFORD, Conn., June 26, 2019 (GLOBE NEWSWIRE) -- Cara Therapeutics, Inc. ( CARA ), a biopharmaceutical company focused on developing and commercializing new chemical entities designed to alleviate pruritus by selectively targeting peripheral kappa opioid receptors, today announced the initiation of a Phase 2 trial of Oral KORSUVA (CR845/difelikefalin) for the treatment of pruritus in patients with hepatic impairment due to primary biliary cholangitis (PBC). (yahoo.com)
  • The pruritus that occurs in herpes zoster prodrome may be a model for pruritus with a neuropathic cause. (aafp.org)
  • Similarly, notalgia paresthetica is thought to be of neuropathic origin, with pruritus limited to the middle of the back. (aafp.org)
  • Pruritus has been classified into the following four key types include neuropathic, cutaneous, psychogenic and neurogenic. (mynewsdesk.com)
  • Based on the neuropathic hypothesis and frequent co-occurrence of chronic pruritus and peripheral neuropathy in the patients undergoing hemodialysis, gabapentin, a medication widely used for a spectrum of neuropathic pain syndromes, has recently been suggested to be effective in the treatment of UP. (clinicaltrials.gov)
  • It can occur in association with a primary rash (eg dermatitis ) or may occur because of hypersensitive nerves in the skin ( neuropathic pruritus). (dermnetnz.org)
  • Neuropathic pruritus is due to compression or degeneration of nerves in the skin, on route to the spine or in the spine itself. (dermnetnz.org)
  • Further understanding of neuropathic pruritus is needed. (ebscohost.com)
  • However, the most difficult cases of pruritus are those without an associated rash. (verywellhealth.com)
  • Similar patterns and antagonistic aspects of pruritus and pain will be mentioned. (springer.com)
  • The primary objective of this study is evaluating the effectiveness of gabapentin in reducing the severity of pruritus in children with burn injuries. (bioportfolio.com)
  • The management of pruritus will be dependent on the underlying cause and diagnosis. (nursinginpractice.com)
  • Management of pruritus in chronic liver disease. (yahoo.com)
  • Based on region, the pruritus therapeutics market is classified into North America, Europe, Asia-Pacific, Latin America, and the Middle East and Africa. (mynewsdesk.com)
  • Europe was the second largest segment in pruritus therapeutics market and is projected to grow at a steady growth rate. (mynewsdesk.com)
  • Key players operating in the global pruritus therapeutics market include Allergan Inc., Amgen Inc., Astellas Pharma Inc., CARA Therapeutics, Novartis AG, and Teva Pharmaceutical Industries Ltd., Ajanta Pharma ltd, Abbot Lab, GSK and Galderma. (mynewsdesk.com)
  • Development of new and a strong pipeline for pruritus therapeutics attributes to the rising demand of pruritus therapeutics over the forecast period. (sbwire.com)
  • To understand the competitive landscape in the market, an analysis of Porter's Five Forces model for the pruritus therapeutics market has also been included. (sbwire.com)
  • The report segments the pruritus therapeutics market on the basis of type, disease type and geography. (sbwire.com)
  • Corticosteroids, antihistamines, local anesthetics, counterirritants, immunosuppressant, calcineurin inhibitors and others are major product segment of pruritus therapeutics market analyzed in this study. (sbwire.com)
  • Corticosteroid was the leading product segment of pruritus therapeutics market in 2014 in terms of revenue. (sbwire.com)
  • On the basis of type of disease, pruritus therapeutics is segmented into atopic dermatitis, allergic contact dermatitis, urticaria and others. (sbwire.com)
  • The key players of the pruritus therapeutics market include Pfizer, Tai Guk Pharmaceutical Company, Cara Therapeutics, Sanofi, Actavis, Trevi Therapeutics, Ocera Therapeutics Inc. and NeRRe Therapeutics. (sbwire.com)
  • Moreover, new product launches and a strong pipeline for pruritus therapeutics are other key drivers for potential growth in this market. (transparencymarketresearch.com)
  • However, a major restraint in the pruritus therapeutics market is lack of awareness of the root cause of pruritus and a universally accepted therapy for pruritus. (transparencymarketresearch.com)
  • Some of the major players that are operating in the pruritus therapeutics market include Allergan Inc., Amgen Inc., Astellas Pharma Inc., CARA Therapeutics, Novartis AG, and Teva Pharmaceutical Industries Ltd. (transparencymarketresearch.com)
  • More attention to pruritus in SSc is needed, including its measurement, etiology, trajectory, and potential methods for intervention. (wiley.com)
  • Diagnosis of pruritus can be challenging, especially for chronic pruritus and requires a structured and systematic approach to identify the underlying cause for the pruritus. (nursinginpractice.com)
  • The team included patients at least 13 years old at the date of informed consent with a bodyweight of 30-120 kg and a confirmed diagnosis of atopic dermatitis with pruritus. (consultantlive.com)
  • Acute and chronic pruritus can represent significant management issues both as a common physiological sensation and as a manifestation of dermatologic and non-dermatologic diseases. (springer.com)
  • The sensation of pruritus is transmitted through C fibers to the dorsal horn of the spinal cord and then to the cerebral cortex via the spinothalamic tract. (aafp.org)
  • Causing an intense need to scratch, pruritus is described as an unpleasant sensation that has a large impact on patients' quality of life. (nursinginpractice.com)
  • Pruritus is usually an unpleasant sensation that elicits a desire to scratch, subjectively quantified by intensity, severity, location, and intractability. (peacehealth.org)
  • Pruritus is a common manifestation of dermatologic diseases, including xerotic eczema, atopic dermatitis, and allergic contact dermatitis. (aafp.org)
  • Although patients without atopic dermatitis perceive mild mechanical stimulation as touch, patients with the condition perceive it as pruritus. (aafp.org)
  • Serum Autotaxin Levels Correlate with Pruritus in Patients with Atopic Dermatitis. (ebscohost.com)
  • A letter to the editor is presented regarding the correlation of the levels of serum autotaxin (ATX) with the pruritus of cholestasis in patients with atopic dermatitis (AD). (ebscohost.com)
  • Serum Gastrin-Releasing Peptide Levels Correlate with Pruritus in Patients with Atopic Dermatitis. (ebscohost.com)
  • A letter to the editor is presented in response to an article on serum gastrin-releasing peptide levels correlation with pruritus in patients with atopic dermatitis that was published in a previous issue. (ebscohost.com)
  • Reports on the need for controlling pruritus during the treatment of atopic dermatitis in children. (ebscohost.com)
  • Focuses on the use of mid-potency topical corticosteroid and calcineurin inhibitor for the rapid relief of pruritus of atopic dermatitis in San Francisco, California. (ebscohost.com)
  • Doxepin may help pruritus linked with atopic dermatitis. (ebscohost.com)
  • Pilot study of the effect of homeopathy on pruritus associated with atopic dermatitis in dogs. (ebscohost.com)
  • Several letters to the editor are presented in response to the article "Pilot study of the effect of individualised homeopathy on the pruritus associated with atopic dermatitis in dogs," by P.B. Hill and colleagues in the March 21, 2009 issue. (ebscohost.com)
  • Therefore, the dual effects of H(4)R antagonists on pruritus and Th2-cell-mediated inflammation point to their therapeutic potential for the treatment of Th2-mediated skin disorders, including atopic dermatitis. (nih.gov)
  • Findings of a new study demonstrate using subcutaneous nemolizumab in addition to topical agents for atopic dermatitis results in a greater reduction in pruritus than placebo plus topical agents. (consultantlive.com)
  • The study, "Trail of Nemolizumab and Topical Agents for Atopic Dermatitis with Pruritus," was published online in the New England Journal of Medicine . (consultantlive.com)
  • Pregnant women are at greater risk to suffer from chronic pruritus, but data on this symptom in this group is very limited. (hindawi.com)
  • Delta-9-tetrahydrocannabinol may be an effective alternative in patients with intractable cholestatic pruritus," investigators concluded. (norml.org)
  • 2002. Preliminary observation with dronabinol in patients with intractable pruritus secondary to cholestatic liver disease . (norml.org)
  • This case report describes an occurrence of intractable localized pruritus after spinal anesthesia in the absence of neuraxial opioid. (ebscohost.com)
  • CTCL, an almost uniformly fatal disorder, affects approximately 18,000 patients in the U.S. During the course of this disease most individuals will experience chronic intractable pruritus unresponsive to standard antipruritic agents (e.g., antihistamines, topical corticosteroids). (medicalnewstoday.com)
  • Chronic intractable pruritus has a significant detrimental impact on quality of life, and for individuals with CTCL, it has been estimated to double the mortality rate compared to those without pruritus. (medicalnewstoday.com)
  • Nagaratnam N., Nagaratnam K., Cheuk G. (2018) Pruritus in the Elderly. (springer.com)
  • Diagnostic tests may be needed to determine the cause of the pruritus. (petplace.com)
  • Treatment is determined by focusing on skin care and the underlying cause of the pruritus ani. (susquehannahealth.org)
  • Histamine, which is released by mast cells in persons with urticaria and other allergic reactions, classically is associated with pruritus. (aafp.org)
  • The histamine H4 receptor mediates inflammation and pruritus in Th2-dependent dermal inflammation. (medscape.com)
  • Pruritus is enhanced or provoked by a number of chemical substances such as prostaglandins, cytokines, histamine, proteases, neuropeptides and bile salts. (mynewsdesk.com)
  • Patients describe intense pruritus and often have eosinophilia. (aafp.org)
  • Limited knowledge of pruritus origin in lichen planus is responsible for the lack of the effective antipruritic treatments. (hindawi.com)
  • Better understanding of mechanisms of pruritus may help develop better treatments. (nih.gov)
  • As a result of favorable government initiatives and an introduction of new products for pruritus treatments, North America dominated the market in 2014. (mynewsdesk.com)
  • Pruritus is caused by cancer, cancer treatments, infection, dry skin and reaction to a drug. (medgadget.com)
  • There is a major opportunity to improve the health and wellbeing of CKD patients through clinicians routinely asking about pruritus and using effective treatments, especially gabapentin," Dr Rayner commented. (renalandurologynews.com)
  • Certain cancer treatments may cause pruritus. (peacehealth.org)
  • Cancer treatments that may cause pruritus include chemotherapy, radiation therapy, and immunotherapy (biologic therapy). (peacehealth.org)
  • This article describes the relationships between inflammation, neuronal transmission of pruritus and central nervous processing and involvement, as well as therapeutic effects on pruritus in order to increase the awareness of limits and adverse side effects of these therapeutic measures. (springer.com)
  • 2 Regardless of the cause, pruritus often is exacerbated by skin inflammation, dry or hot ambient conditions, skin vasodilation, and psychologic stressors. (aafp.org)
  • Broadly, pruritus can be due to a primary dermatological disorder or to an underlying system disease. (springer.com)
  • Pruritus is the most common dermatological disorder. (mynewsdesk.com)
  • Elorac, Inc., a rapidly growing specialty pharmaceutical company focused on the treatment of dermatological disorders announced that it has been granted Orphan Drug Designation by the U.S. Food and Drug Administration for its naloxone lotion for the topical treatment of pruritus accompanying cutaneous t-cell lymphoma (CTCL, also known as mycosis fungoides). (medicalnewstoday.com)
  • Writing in the August 2002 issue of the American Journal of Gastroentrology , investigators from the University of Miami Department of Medicine reported successful treatment of pruritus with 5 mg of THC in three patients with cholestatic liver disease. (norml.org)
  • Here, we conducted a systematic literature review to evaluate conventional treatment strategy, current pathophysiologic understanding, and the role of new therapies in the context of cholestatic pruritus. (nih.gov)
  • Pruritus continues to be a significant comorbidity in patients with chronic cholestatic liver diseases and may be exacerbated by certain bile acid-related drugs," said Derek Chalmers, Ph.D., D.Sc. (yahoo.com)
  • Secondary Pruritus Ani results from an underlying disorder. (hpathy.com)
  • opioid-induced pruritus may be the most important in palliative medicine. (nih.gov)
  • Intravenous and subcutaneous formulations have been used to treat opiate overdoses, but Elorac's naloxone lotion is unique as the only topical formulation intended to treat the pruritus associated with mycosis fungoides. (medicalnewstoday.com)
  • Similarly, topical therapeutic formulations are also found to be extremely effective pertaining to pruritus. (transparencymarketresearch.com)
  • Pruritus may be extremely difficult to control, as therapeutic options are limited. (wellnessresources.com)
  • Furthermore, chronic pruritus is becoming a burden to society mainly due to the treatment-related costs, which is particularly high due to the elevation rate of therapeutic failure. (mynewsdesk.com)
  • As far as therapeutic medication is concerned, several remedies are available to treat Pruritus ani that can be selected on the basis of cause, sensations and modalities of the complaints. (hpathy.com)
  • When there is a rash that goes along with the pruritus, the cause is often easily determined and treated. (verywellhealth.com)
  • Whether pruritus ani is an isolated problem or part of another skin disorder, irritation from stools and from cleansing after bowel movements keeps the rash going. (digitalnaturopath.com)
  • Chronic renal failure is a vital cause of persistent pruritus. (mynewsdesk.com)
  • Serotonin appears to be a key component of the pruritus that occurs with several diseases, including polycythemia vera, uremia, cholestasis and lymphoma, and of morphine-associated pruritus. (aafp.org)
  • Pruritus is associated with other skin diseases, including secondary bacterial skin infections (pyoderma) and secondary yeast infections. (petplace.com)
  • Many skin diseases can cause or can contribute to pruritus. (petplace.com)
  • Smith GP, Argobi Y. Pruritus in Autoimmune Connective Tissue Diseases. (harvard.edu)
  • Since, many patients of chronic pruritus have skin lesions in the absence of skin diseases due to scratching or skin dryness or insect bite. (transparencymarketresearch.com)
  • Despite the wide array of diseases that may present with pruritus, a systematic evaluation of the differential using a good history, review of systems, and appropriate blood work will lead to a rational and finite group of etiologies. (peacehealth.org)
  • 2 Narcotic antagonists have been used successfully to relieve pruritus in patients with cholestasis. (aafp.org)
  • Cholestasis-induced pruritus treated with ultraviolet B phototherapy: An observational case series study. (thefreedictionary.com)
  • Hepatogenic pruritus is more common in intrahepatic than extrahepatic cholestasis. (dermnetnz.org)
  • 9,11,12 ESRD pruritus is associated with elevated C-reactive proteins and other inflammatory cytokines, hinting that there is an upregulated inflammatory component in this form of pruritus. (uspharmacist.com)
  • What are cutaneous signs of pruritus? (dermnetnz.org)
  • If your dog is showing signs of pruritus and constantly trying to relieve itches, consult your veterinarian so they can find the cause and prescribe treatment. (dogtime.com)
  • Has your dog ever shown signs of pruritus? (dogtime.com)
  • Relief of pruritus with doxepin. (ebscohost.com)
  • Oil baths and emollients are also helpful for relief of pruritus. (cfp.ca)
  • Chronic licking of the feet is also a symptom of pruritus. (petplace.com)