AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesInformation Science
PorphyrinsOncogene Proteins v-sisOncogene Protein tpr-metOncogene Protein v-mafOncogene Protein gp140(v-fms)Oncogene Proteins v-mosOncogene Protein p55(v-myc)Oncogene Protein p65(gag-jun)Oncogene Proteins v-rafOncogene Proteins v-fosOncogene Protein v-crkOncogene Proteins v-mybOncogene Protein v-cblOncogene Proteins v-erbBOncogene Proteins v-ablOncogenesOncogene Proteins v-relOncogene Proteins v-erbAOncogene ProteinsOncogene Protein p21(ras)Oncogene Protein pp60(v-src)Oncogene Proteins, ViralOncogene Proteins, FusionGenes, rasOncogene Protein v-aktCell Transformation, NeoplasticProto-OncogenesProto-Oncogene ProteinsGenes, mycGene AmplificationProto-Oncogene Proteins c-mycProto-Oncogene Proteins p21(ras)Gene Expression Regulation, NeoplasticRetroviridae Proteins, OncogenicBase SequenceCell Transformation, ViralTransfectionCell LineCell Line, TransformedMolecular Sequence DataCell Line, TumorGenes, erbB-2MutationTumor Cells, Culturedras ProteinsCell DivisionRNA, MessengerSignal TransductionTranscription, GeneticDNA, NeoplasmReceptor, erbB-2Translocation, Genetic3T3 CellsGene Expression RegulationMice, NudeNuclear ProteinsTranscription FactorsProtein-Tyrosine KinasesRetroviridaeMice, TransgenicDNA-Binding ProteinsTumor Suppressor Protein p53FibroblastsAmino Acid SequenceOncogene FusionNeoplasm ProteinsCell ProliferationGenes, srcSarcoma Viruses, MurineApoptosisAvian leukosis virusPromoter Regions, GeneticFusion Proteins, bcr-ablGene ExpressionHarvey murine sarcoma virusAdenovirus E1A ProteinsAntigens, Polyomavirus TransformingCells, Cultured
Porphyrins
A group of compounds containing the porphin structure, four pyrrole rings connected by methine bridges in a cyclic configuration to which a variety of side chains are attached. The nature of the side chain is indicated by a prefix, as uroporphyrin, hematoporphyrin, etc. The porphyrins, in combination with iron, form the heme component in biologically significant compounds such as hemoglobin and myoglobin.
Oncogene Proteins v-sis
Transforming proteins coded by sis oncogenes. Transformation of cells by v-sis is related to its interaction with the PDGF receptor and also its ability to alter other transcription factors.
Oncogene Protein tpr-met
The GENETIC TRANSLATION product from a GENE FUSION between a sequence from the tpr protein gene on the human CHROMOSOME 1 and the gene for PROTO-ONCOGENE PROTEINS C-MET.
Oncogene Protein v-maf
An oncogene protein that was originally isolated from a spontaneous musculo-aponeurotic FIBROSARCOMA in CHICKEN and shown to be the transforming gene of the avian retrovirus AS42. It is a basic leucine zipper TRANSCRIPTION FACTOR and the founding member of the MAF TRANSCRIPTION FACTORS.
Oncogene Protein gp140(v-fms)
Transforming glycoprotein coded by the fms oncogene from the Susan McDonough strain of feline sarcoma virus (SM-FeSV). The oncogene protein v-fms lacks sequences, which, in the highly homologous proto-oncogene protein c-fms (CSF-1 receptor), normally serve to regulate its tyrosine kinase activity. The missing sequences in v-fms mimic the effect of ligand and lead to constitutive cell growth. The protein gp120(v-fms) is post-translationally modified to generate gp140(v-fms).
Oncogene Proteins v-mos
Transforming proteins coded by mos oncogenes. The v-mos proteins were originally isolated from the Moloney murine sarcoma virus (Mo-MSV).
Oncogene Protein p55(v-myc)
Transforming protein coded by myc oncogenes. The v-myc protein has been found in several replication-defective avian retrovirus isolates which induce a broad spectrum of malignancies.
Oncogene Protein p65(gag-jun)
Transforming protein coded by jun oncogenes (GENES, JUN). This is a gag-onc fusion protein of about 65 kDa derived from avian sarcoma virus. v-jun lacks a negative regulatory domain that regulates transcription in c-jun.
Oncogene Proteins v-raf
A family of transforming proteins isolated from retroviruses such as MOUSE SARCOMA VIRUSES. They are viral-derived members of the raf-kinase family of serine-theonine kinases.
Oncogene Proteins v-fos
Transforming proteins coded by fos oncogenes. These proteins have been found in the Finkel-Biskis-Jinkins (FBJ-MSV) and Finkel-Biskis-Reilly (FBR-MSV) murine sarcoma viruses which induce osteogenic sarcomas in mice. The FBJ-MSV v-fos gene encodes a p55-kDa protein and the FBR-MSV v-fos gene encodes a p75-kDa fusion protein.
Oncogene Protein v-crk
A signal transducing adaptor protein that is encoded by the crk ONCOGENE from TYPE C AVIAN RETROVIRUSES. It contains SRC HOMOLOGY DOMAINS and is closely related to its cellular homolog, PROTO-ONCOGENE PROTEIN C-CRK.
Oncogene Proteins v-myb
Transforming proteins coded by myb oncogenes. Transformation of cells by v-myb in conjunction with v-ets is seen in the avian E26 leukemia virus.
Oncogene Protein v-cbl
An oncoprotein from the Cas NS-1 murine retrovirus that induces pre- B-CELL LYMPHOMA and MYELOID LEUKEMIAS. v-cbl protein is a tyrosine-phosphorylated, truncated form of its cellular homologue, PROTO-ONCOGENE PROTEIN C-CBL.
Oncogene Proteins v-erbB
Transforming proteins encoded by erbB oncogenes from the avian erythroblastosis virus. The protein is a truncated form of the EGF receptor (RECEPTOR, EPIDERMAL GROWTH FACTOR) whose kinase domain is constitutively activated by deletion of the ligand-binding domain.
Oncogene Proteins v-abl
Transforming proteins encoded by the abl oncogenes. Oncogenic transformation of c-abl to v-abl occurs by insertional activation that results in deletions of specific N-terminal amino acids.
Oncogenes
Genes whose gain-of-function alterations lead to NEOPLASTIC CELL TRANSFORMATION. They include, for example, genes for activators or stimulators of CELL PROLIFERATION such as growth factors, growth factor receptors, protein kinases, signal transducers, nuclear phosphoproteins, and transcription factors. A prefix of "v-" before oncogene symbols indicates oncogenes captured and transmitted by RETROVIRUSES; the prefix "c-" before the gene symbol of an oncogene indicates it is the cellular homolog (PROTO-ONCOGENES) of a v-oncogene.
Oncogene Proteins v-rel
Transforming proteins coded by rel oncogenes. The v-rel protein competes with rel-related proteins and probably transforms cells by acting as a dominant negative version of c-rel. This results in the induction of a broad range of leukemias and lymphomas.
Oncogene Proteins v-erbA
Transforming proteins encoded by erbA oncogenes from the avian erythroblastosis virus. They are truncated versions of c-erbA, the thyroid hormone receptor (RECEPTORS, THYROID HORMONE) that have retained both the DNA-binding and hormone-binding domains. Mutations in the hormone-binding domains abolish the transcriptional activation function. v-erbA acts as a dominant repressor of c-erbA, inducing transformation by disinhibiting proliferation.
Oncogene Proteins
Proteins coded by oncogenes. They include proteins resulting from the fusion of an oncogene and another gene (ONCOGENE PROTEINS, FUSION).
Oncogene Protein p21(ras)
Transforming protein encoded by ras oncogenes. Point mutations in the cellular ras gene (c-ras) can also result in a mutant p21 protein that can transform mammalian cells. Oncogene protein p21(ras) has been directly implicated in human neoplasms, perhaps accounting for as much as 15-20% of all human tumors. This enzyme was formerly listed as EC 3.6.1.47.
Oncogene Protein pp60(v-src)
A tyrosine-specific protein kinase encoded by the v-src oncogene of ROUS SARCOMA VIRUS. The transforming activity of pp60(v-src) depends on both the lack of a critical carboxy-terminal tyrosine phosphorylation site at position 527, and the attachment of pp60(v-src) to the plasma membrane which is accomplished by myristylation of its N-terminal glycine.
Oncogene Proteins, Viral
Products of viral oncogenes, most commonly retroviral oncogenes. They usually have transforming and often protein kinase activities.
Oncogene Proteins, Fusion
The GENETIC TRANSLATION products of the fusion between an ONCOGENE and another gene. The latter may be of viral or cellular origin.
Genes, ras
Family of retrovirus-associated DNA sequences (ras) originally isolated from Harvey (H-ras, Ha-ras, rasH) and Kirsten (K-ras, Ki-ras, rasK) murine sarcoma viruses. Ras genes are widely conserved among animal species and sequences corresponding to both H-ras and K-ras genes have been detected in human, avian, murine, and non-vertebrate genomes. The closely related N-ras gene has been detected in human neuroblastoma and sarcoma cell lines. All genes of the family have a similar exon-intron structure and each encodes a p21 protein.
Oncogene Protein v-akt
A viral oncoprotein originally isolated from a murine T CELL LYMPHOMA infected with the acutely transforming retrovirus AKT8. v-akt protein is the viral homologue of PROTO-ONCOGENE PROTEINS C-AKT.
Cell Transformation, Neoplastic
Cell changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm, and other attributes conferring the ability to invade, metastasize, and kill.
Proto-Oncogenes
Normal cellular genes homologous to viral oncogenes. The products of proto-oncogenes are important regulators of biological processes and appear to be involved in the events that serve to maintain the ordered procession through the cell cycle. Proto-oncogenes have names of the form c-onc.
Proto-Oncogene Proteins
Products of proto-oncogenes. Normally they do not have oncogenic or transforming properties, but are involved in the regulation or differentiation of cell growth. They often have protein kinase activity.
Genes, myc
Family of retrovirus-associated DNA sequences (myc) originally isolated from an avian myelocytomatosis virus. The proto-oncogene myc (c-myc) codes for a nuclear protein which is involved in nucleic acid metabolism and in mediating the cellular response to growth factors. Truncation of the first exon, which appears to regulate c-myc expression, is crucial for tumorigenicity. The human c-myc gene is located at 8q24 on the long arm of chromosome 8.
Gene Amplification
A selective increase in the number of copies of a gene coding for a specific protein without a proportional increase in other genes. It occurs naturally via the excision of a copy of the repeating sequence from the chromosome and its extrachromosomal replication in a plasmid, or via the production of an RNA transcript of the entire repeating sequence of ribosomal RNA followed by the reverse transcription of the molecule to produce an additional copy of the original DNA sequence. Laboratory techniques have been introduced for inducing disproportional replication by unequal crossing over, uptake of DNA from lysed cells, or generation of extrachromosomal sequences from rolling circle replication.
Proto-Oncogene Proteins c-myc
Cellular DNA-binding proteins encoded by the c-myc genes. They are normally involved in nucleic acid metabolism and in mediating the cellular response to growth factors. Elevated and deregulated (constitutive) expression of c-myc proteins can cause tumorigenesis.
Proto-Oncogene Proteins p21(ras)
Cellular proteins encoded by the H-ras, K-ras and N-ras genes. The proteins have GTPase activity and are involved in signal transduction as monomeric GTP-binding proteins. Elevated levels of p21 c-ras have been associated with neoplasia. This enzyme was formerly listed as EC 3.6.1.47.
Gene Expression Regulation, Neoplastic
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action in neoplastic tissue.
Retroviridae Proteins, Oncogenic
Retroviral proteins that have the ability to transform cells. They can induce sarcomas, leukemias, lymphomas, and mammary carcinomas. Not all retroviral proteins are oncogenic.
Base Sequence
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
Cell Transformation, Viral
An inheritable change in cells manifested by changes in cell division and growth and alterations in cell surface properties. It is induced by infection with a transforming virus.
Transfection
The uptake of naked or purified DNA by CELLS, usually meaning the process as it occurs in eukaryotic cells. It is analogous to bacterial transformation (TRANSFORMATION, BACTERIAL) and both are routinely employed in GENE TRANSFER TECHNIQUES.
Cell Line
Established cell cultures that have the potential to propagate indefinitely.
Cell Line, Transformed
Eukaryotic cell line obtained in a quiescent or stationary phase which undergoes conversion to a state of unregulated growth in culture, resembling an in vitro tumor. It occurs spontaneously or through interaction with viruses, oncogenes, radiation, or drugs/chemicals.
Molecular Sequence Data
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Cell Line, Tumor
A cell line derived from cultured tumor cells.
Genes, erbB-2
The erbB-2 gene is a proto-oncogene that codes for the erbB-2 receptor (RECEPTOR, ERBB-2), a protein with structural features similar to the epidermal growth factor receptor. Its name originates from the viral oncogene homolog (v-erbB) which is a truncated form of the chicken erbB gene found in the avian erythroblastosis virus. Overexpression and amplification of the gene is associated with a significant number of adenocarcinomas. The human c-erbB-2 gene is located at 17q21.2.
Mutation
Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.
Tumor Cells, Cultured
Cells grown in vitro from neoplastic tissue. If they can be established as a TUMOR CELL LINE, they can be propagated in cell culture indefinitely.
ras Proteins
Small, monomeric GTP-binding proteins encoded by ras genes (GENES, RAS). The protooncogene-derived protein, PROTO-ONCOGENE PROTEIN P21(RAS), plays a role in normal cellular growth, differentiation and development. The oncogene-derived protein (ONCOGENE PROTEIN P21(RAS)) can play a role in aberrant cellular regulation during neoplastic cell transformation (CELL TRANSFORMATION, NEOPLASTIC). This enzyme was formerly listed as EC 3.6.1.47.
Cell Division
The fission of a CELL. It includes CYTOKINESIS, when the CYTOPLASM of a cell is divided, and CELL NUCLEUS DIVISION.
RNA, Messenger
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
Signal Transduction
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
Transcription, Genetic
The biosynthesis of RNA carried out on a template of DNA. The biosynthesis of DNA from an RNA template is called REVERSE TRANSCRIPTION.
DNA, Neoplasm
DNA present in neoplastic tissue.
Receptor, erbB-2
A cell surface protein-tyrosine kinase receptor that is overexpressed in a variety of ADENOCARCINOMAS. It has extensive homology to and heterodimerizes with the EGF RECEPTOR, the ERBB-3 RECEPTOR, and the ERBB-4 RECEPTOR. Activation of the erbB-2 receptor occurs through heterodimer formation with a ligand-bound erbB receptor family member.
Translocation, Genetic
A type of chromosome aberration characterized by CHROMOSOME BREAKAGE and transfer of the broken-off portion to another location, often to a different chromosome.
3T3 Cells
Cell lines whose original growing procedure consisted being transferred (T) every 3 days and plated at 300,000 cells per plate (J Cell Biol 17:299-313, 1963). Lines have been developed using several different strains of mice. Tissues are usually fibroblasts derived from mouse embryos but other types and sources have been developed as well. The 3T3 lines are valuable in vitro host systems for oncogenic virus transformation studies, since 3T3 cells possess a high sensitivity to CONTACT INHIBITION.
Gene Expression Regulation
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control (induction or repression) of gene action at the level of transcription or translation.
Mice, Nude
Mutant mice homozygous for the recessive gene "nude" which fail to develop a thymus. They are useful in tumor studies and studies on immune responses.
Nuclear Proteins
Proteins found in the nucleus of a cell. Do not confuse with NUCLEOPROTEINS which are proteins conjugated with nucleic acids, that are not necessarily present in the nucleus.
Transcription Factors
Endogenous substances, usually proteins, which are effective in the initiation, stimulation, or termination of the genetic transcription process.
Protein-Tyrosine Kinases
Protein kinases that catalyze the PHOSPHORYLATION of TYROSINE residues in proteins with ATP or other nucleotides as phosphate donors.
Retroviridae
Family of RNA viruses that infects birds and mammals and encodes the enzyme reverse transcriptase. The family contains seven genera: DELTARETROVIRUS; LENTIVIRUS; RETROVIRUSES TYPE B, MAMMALIAN; ALPHARETROVIRUS; GAMMARETROVIRUS; RETROVIRUSES TYPE D; and SPUMAVIRUS. A key feature of retrovirus biology is the synthesis of a DNA copy of the genome which is integrated into cellular DNA. After integration it is sometimes not expressed but maintained in a latent state (PROVIRUSES).
Mice, Transgenic
Laboratory mice that have been produced from a genetically manipulated EGG or EMBRYO, MAMMALIAN.
DNA-Binding Proteins
Proteins which bind to DNA. The family includes proteins which bind to both double- and single-stranded DNA and also includes specific DNA binding proteins in serum which can be used as markers for malignant diseases.
Tumor Suppressor Protein p53
Nuclear phosphoprotein encoded by the p53 gene (GENES, P53) whose normal function is to control CELL PROLIFERATION and APOPTOSIS. A mutant or absent p53 protein has been found in LEUKEMIA; OSTEOSARCOMA; LUNG CANCER; and COLORECTAL CANCER.
Fibroblasts
Connective tissue cells which secrete an extracellular matrix rich in collagen and other macromolecules.
Amino Acid Sequence
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
Oncogene Fusion
The GENETIC RECOMBINATION of the parts of two or more GENES, including an ONCOGENE as at least one of the fusion partners. Such gene fusions are often detected in neoplastic cells and are transcribed into ONCOGENE FUSION PROTEINS.
Neoplasm Proteins
Proteins whose abnormal expression (gain or loss) are associated with the development, growth, or progression of NEOPLASMS. Some neoplasm proteins are tumor antigens (ANTIGENS, NEOPLASM), i.e. they induce an immune reaction to their tumor. Many neoplasm proteins have been characterized and are used as tumor markers (BIOMARKERS, TUMOR) when they are detectable in cells and body fluids as monitors for the presence or growth of tumors. Abnormal expression of ONCOGENE PROTEINS is involved in neoplastic transformation, whereas the loss of expression of TUMOR SUPPRESSOR PROTEINS is involved with the loss of growth control and progression of the neoplasm.
Cell Proliferation
All of the processes involved in increasing CELL NUMBER including CELL DIVISION.
Genes, src
Retrovirus-associated DNA sequences (src) originally isolated from the Rous sarcoma virus (RSV). The proto-oncogene src (c-src) codes for a protein that is a member of the tyrosine kinase family and was the first proto-oncogene identified in the human genome. The human c-src gene is located at 20q12-13 on the long arm of chromosome 20.
Sarcoma Viruses, Murine
A group of replication-defective viruses, in the genus GAMMARETROVIRUS, which are capable of transforming cells, but which replicate and produce tumors only in the presence of Murine leukemia viruses (LEUKEMIA VIRUS, MURINE).
Apoptosis
One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.
Avian leukosis virus
The type species of ALPHARETROVIRUS producing latent or manifest lymphoid leukosis in fowl.
Promoter Regions, Genetic
DNA sequences which are recognized (directly or indirectly) and bound by a DNA-dependent RNA polymerase during the initiation of transcription. Highly conserved sequences within the promoter include the Pribnow box in bacteria and the TATA BOX in eukaryotes.
Fusion Proteins, bcr-abl
Translation products of a fusion gene derived from CHROMOSOMAL TRANSLOCATION of C-ABL GENES to the genetic locus of the breakpoint cluster region gene on chromosome 22. Several different variants of the bcr-abl fusion proteins occur depending upon the precise location of the chromosomal breakpoint. These variants can be associated with distinct subtypes of leukemias such as PRECURSOR CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; LEUKEMIA, MYELOGENOUS, CHRONIC, BCR-ABL POSITIVE; and NEUTROPHILIC LEUKEMIA, CHRONIC.
Gene Expression
The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION.
Harvey murine sarcoma virus
A replication-defective mouse sarcoma virus (SARCOMA VIRUSES, MURINE) first described by J.J. Harvey in 1964.
Adenovirus E1A Proteins
Proteins transcribed from the E1A genome region of ADENOVIRUSES which are involved in positive regulation of transcription of the early genes of host infection.
Antigens, Polyomavirus Transforming
Polyomavirus antigens which cause infection and cellular transformation. The large T antigen is necessary for the initiation of viral DNA synthesis, repression of transcription of the early region and is responsible in conjunction with the middle T antigen for the transformation of primary cells. Small T antigen is necessary for the completion of the productive infection cycle.
Cells, Cultured
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.

Stromal cells mediate retinoid-dependent functions essential for renal development. (1/24774)

The essential role of vitamin A and its metabolites, retinoids, in kidney development has been demonstrated in vitamin A deficiency and gene targeting studies. Retinoids signal via nuclear transcription factors belonging to the retinoic acid receptor (RAR) and retinoid X receptor (RXR) families. Inactivation of RARaplpha and RARbeta2 receptors together, but not singly, resulted in renal malformations, suggesting that within a given renal cell type, their concerted function is required for renal morphogenesis. At birth, RARalpha beta2(-) mutants displayed small kidneys, containing few ureteric bud branches, reduced numbers of nephrons and lacking the nephrogenic zone where new nephrons are continuously added. These observations have prompted us to investigate the role of RARalpha and RARbeta2 in renal development in detail. We have found that within the embryonic kidney, RARalpha and RARbeta2 are colocalized in stromal cells, but not in other renal cell types, suggesting that stromal cells mediate retinoid-dependent functions essential for renal development. Analysis of RARalpha beta2(-) mutant kidneys at embryonic stages revealed that nephrons were formed and revealed no changes in the intensity or distribution of molecular markers specific for different metanephric mesenchymal cell types. In contrast the development of the collecting duct system was greatly impaired in RARalpha beta2(-) mutant kidneys. Fewer ureteric bud branches were present, and ureteric bud ends were positioned abnormally, at a distance from the renal capsule. Analysis of genes important for ureteric bud morphogenesis revealed that the proto-oncogene c-ret was downregulated. Our results suggest that RARalpha and RARbeta2 are required for generating stromal cell signals that maintain c-ret expression in the embryonic kidney. Since c-ret signaling is required for ureteric bud morphogenesis, loss of c-ret expression is a likely cause of impaired ureteric bud branching in RARalpha beta2(-) mutants.  (+info)

VEGF is required for growth and survival in neonatal mice. (2/24774)

We employed two independent approaches to inactivate the angiogenic protein VEGF in newborn mice: inducible, Cre-loxP- mediated gene targeting, or administration of mFlt(1-3)-IgG, a soluble VEGF receptor chimeric protein. Partial inhibition of VEGF achieved by inducible gene targeting resulted in increased mortality, stunted body growth and impaired organ development, most notably of the liver. Administration of mFlt(1-3)-IgG, which achieves a higher degree of VEGF inhibition, resulted in nearly complete growth arrest and lethality. Ultrastructural analysis documented alterations in endothelial and other cell types. Histological and biochemical changes consistent with liver and renal failure were observed. Endothelial cells isolated from the liver of mFlt(1-3)-IgG-treated neonates demonstrated an increased apoptotic index, indicating that VEGF is required not only for proliferation but also for survival of endothelial cells. However, such treatment resulted in less significant alterations as the animal matured, and the dependence on VEGF was eventually lost some time after the fourth postnatal week. Administration of mFlt(1-3)-IgG to juvenile mice failed to induce apoptosis in liver endothelial cells. Thus, VEGF is essential for growth and survival in early postnatal life. However, in the fully developed animal, VEGF is likely to be involved primarily in active angiogenesis processes such as corpus luteum development.  (+info)

FGF8 induces formation of an ectopic isthmic organizer and isthmocerebellar development via a repressive effect on Otx2 expression. (3/24774)

Beads containing recombinant FGF8 (FGF8-beads) were implanted in the prospective caudal diencephalon or midbrain of chick embryos at stages 9-12. This induced the neuroepithelium rostral and caudal to the FGF8-bead to form two ectopic, mirror-image midbrains. Furthermore, cells in direct contact with the bead formed an outgrowth that protruded laterally from the neural tube. Tissue within such lateral outgrowths developed proximally into isthmic nuclei and distally into a cerebellum-like structure. These morphogenetic effects were apparently due to FGF8-mediated changes in gene expression in the vicinity of the bead, including a repressive effect on Otx2 and an inductive effect on En1, Fgf8 and Wnt1 expression. The ectopic Fgf8 and Wnt1 expression domains formed nearly complete concentric rings around the FGF8-bead, with the Wnt1 ring outermost. These observations suggest that FGF8 induces the formation of a ring-like ectopic signaling center (organizer) in the lateral wall of the brain, similar to the one that normally encircles the neural tube at the isthmic constriction, which is located at the boundary between the prospective midbrain and hindbrain. This ectopic isthmic organizer apparently sends long-range patterning signals both rostrally and caudally, resulting in the development of the two ectopic midbrains. Interestingly, our data suggest that these inductive signals spread readily in a caudal direction, but are inhibited from spreading rostrally across diencephalic neuromere boundaries. These results provide insights into the mechanism by which FGF8 induces an ectopic organizer and suggest that a negative feedback loop between Fgf8 and Otx2 plays a key role in patterning the midbrain and anterior hindbrain.  (+info)

A Wnt5a pathway underlies outgrowth of multiple structures in the vertebrate embryo. (4/24774)

Morphogenesis depends on the precise control of basic cellular processes such as cell proliferation and differentiation. Wnt5a may regulate these processes since it is expressed in a gradient at the caudal end of the growing embryo during gastrulation, and later in the distal-most aspect of several structures that extend from the body. A loss-of-function mutation of Wnt5a leads to an inability to extend the A-P axis due to a progressive reduction in the size of caudal structures. In the limbs, truncation of the proximal skeleton and absence of distal digits correlates with reduced proliferation of putative progenitor cells within the progress zone. However, expression of progress zone markers, and several genes implicated in distal outgrowth and patterning including Distalless, Hoxd and Fgf family members was not altered. Taken together with the outgrowth defects observed in the developing face, ears and genitals, our data indicates that Wnt5a regulates a pathway common to many structures whose development requires extension from the primary body axis. The reduced number of proliferating cells in both the progress zone and the primitive streak mesoderm suggests that one function of Wnt5a is to regulate the proliferation of progenitor cells.  (+info)

Membrane-tethered Drosophila Armadillo cannot transduce Wingless signal on its own. (5/24774)

Drosophila Armadillo and its vertebrate homolog beta-catenin are key effectors of Wingless/Wnt signaling. In the current model, Wingless/Wnt signal stabilizes Armadillo/beta-catenin, which then accumulates in nuclei and binds TCF/LEF family proteins, forming bipartite transcription factors which activate transcription of Wingless/Wnt responsive genes. This model was recently challenged. Overexpression in Xenopus of membrane-tethered beta-catenin or its paralog plakoglobin activates Wnt signaling, suggesting that nuclear localization of Armadillo/beta-catenin is not essential for signaling. Tethered plakoglobin or beta-catenin might signal on their own or might act indirectly by elevating levels of endogenous beta-catenin. We tested these hypotheses in Drosophila by removing endogenous Armadillo. We generated a series of mutant Armadillo proteins with altered intracellular localizations, and expressed these in wild-type and armadillo mutant backgrounds. We found that membrane-tethered Armadillo cannot signal on its own; however it can function in adherens junctions. We also created mutant forms of Armadillo carrying heterologous nuclear localization or nuclear export signals. Although these signals alter the subcellular localization of Arm when overexpressed in Xenopus, in Drosophila they have little effect on localization and only subtle effects on signaling. This supports a model in which Armadillo's nuclear localization is key for signaling, but in which Armadillo intracellular localization is controlled by the availability and affinity of its binding partners.  (+info)

Intracellular signalling: PDK1--a kinase at the hub of things. (6/24774)

Phosphoinositide-dependent kinase 1 (PDK1) is at the hub of many signalling pathways, activating PKB and PKC isoenzymes, as well as p70 S6 kinase and perhaps PKA. PDK1 action is determined by colocalization with substrate and by target site availability, features that may enable it to operate in both resting and stimulated cells.  (+info)

Alzheimer's disease: clues from flies and worms. (7/24774)

Presenilin mutations give rise to familial Alzheimer's disease and result in elevated production of amyloid beta peptide. Recent evidence that presenilins act in developmental signalling pathways may be the key to understanding how senile plaques, neurofibrillary tangles and apoptosis are all biochemically linked.  (+info)

Concomitant activation of pathways downstream of Grb2 and PI 3-kinase is required for MET-mediated metastasis. (8/24774)

The Met tyrosine kinase - the HGF receptor - induces cell transformation and metastasis when constitutively activated. Met signaling is mediated by phosphorylation of two carboxy-terminal tyrosines which act as docking sites for a number of SH2-containing molecules. These include Grb2 and p85 which couple the receptor, respectively, with Ras and PI 3-kinase. We previously showed that a Met mutant designed to obtain preferential coupling with Grb2 (Met2xGrb2) is permissive for motility, increases transformation, but - surprisingly - is impaired in causing invasion and metastasis. In this work we used Met mutants optimized for binding either p85 alone (Met2xPI3K) or p85 and Grb2 (MetPI3K/Grb2) to evaluate the relative importance of Ras and PI 3-kinase as downstream effectors of Met. Met2xPI3K was competent in eliciting motility, but not transformation, invasion, or metastasis. Conversely, MetP13K/Grb2 induced motility, transformation, invasion and metastasis as efficiently as wild type Met. Furthermore, the expression of constitutively active PI 3-kinase in cells transformed by the Met2xGrb2 mutant, fully rescued their ability to invade and metastasize. These data point to a central role for PI 3-kinase in Met-mediated invasiveness, and indicate that simultaneous activation of Ras and PI 3-kinase is required to unleash the Met metastatic potential.  (+info)

Cryopreservation: a cold solutionCryopreservation: a cold solution
The popularity reached by the genetic manipulation of laboratory animals to create new models for studying human diseases, produced in turn, that the techniques for assisted reproduction cons
https://www.labroots.com/webinar/cryopreservation-a-cold-solution
Up-regulation of soluble Axl and Mer receptor tyrosine kinases negatively correlates with Gas6 in established multiple...Up-regulation of soluble Axl and Mer receptor tyrosine kinases negatively correlates with Gas6 in established multiple...
TY - JOUR. T1 - Up-regulation of soluble Axl and Mer receptor tyrosine kinases negatively correlates with Gas6 in established multiple sclerosis lesions. AU - Weinger, Jason G.. AU - Omari, Kakuri M.. AU - Marsden, Kurt. AU - Raine, Cedric S.. AU - Shafit-Zagardo, Bridget. PY - 2009/7. Y1 - 2009/7. N2 - Multiple sclerosis is a disease that is characterized by inflammation, demyelination, and axonal damage; it ultimately forms gliotic scars and lesions that severely compromise the function of the central nervous system. Evidence has shown previously that altered growth factor receptor signaling contributes to lesion formation, impedes recovery, and plays a role in disease progression. Growth arrest-specific protein 6 (Gas6), the ligand for the TAM receptor tyrosine kinase family, consisting of Tyro3, Axl, and Mer, is important for cell growth, survival, and clearance of debris. In this study, we show that levels of membrane-bound Mer (205 kd), soluble Mer (⌈150 kd), and soluble Axl (80 kd) were ...
https://einstein.pure.elsevier.com/en/publications/up-regulation-of-soluble-axl-and-mer-receptor-tyrosine-kinases-ne-2
Anti-MerTK (c-MER, c-Mer Proto-oncogene Tyrosine Kinase, MER, MER Receptor Tyrosine Kinase, MERK, ME | United States Biological...Anti-MerTK (c-MER, c-Mer Proto-oncogene Tyrosine Kinase, MER, MER Receptor Tyrosine Kinase, MERK, ME | United States Biological...
Buy Anti-MerTK (c-MER, c-Mer Proto-oncogene Tyrosine Kinase, MER, MER Receptor Tyrosine Kinase, MERK, ME, item number: M2995-05.100 from United States Biological at Biomol!
https://www.biomol.com/products/antibodies/primary-antibodies/general/anti-mertk-c-mer-c-mer-proto-oncogene-tyrosine-kinase-mer-mer-receptor-tyrosine-kinase-merk-me-m2995-05.100
DSpace at EWHA: Upregulation of mer receptor tyrosine kinase signaling attenuated lipopolysaccharide-induced lung inflammationsDSpace at EWHA: Upregulation of mer receptor tyrosine kinase signaling attenuated lipopolysaccharide-induced lung inflammations
Mer receptor tyrosine kinase (Mer) signaling plays a central role in the intrinsic inhibition of the inflammatory response to Tolllike receptor activation. Previously, we found that lung Mer protein expression decreased after lipopolysaccharide (LPS) treatment due to enhanced Mer cleavage. The purpose of the present study was to examine whether pharmacologically restored membrane-bound Mer expression upregulates the Mer signaling pathways and suppresses lung inflammatory responses. Pretreatment with the ADAM17 (a disintegrin and metalloproteinase-17) inhibitor TAPI-0 (tumor necrosis factor alpha protease inhibitor-0) reduced LPS-induced production of soluble Mer protein in bronchoalveolar lavage (BAL) fluid, restored membrane-bound Mer expression, and increased Mer activation in alveolar macrophages and lungs after LPS treatment. TAPI-0 also enhanced Mer downstream signaling, including phosphorylation of protein kinase b, focal adhesion kinase, and signal transducer and activator of ...
http://dspace.ewha.ac.kr/handle/2015.oak/223344
Requirement for the SnoN Oncoprotein in Transforming Growth Factor β-Induced Oncogenic Transformation of Fibroblast Cells |...Requirement for the SnoN Oncoprotein in Transforming Growth Factor β-Induced Oncogenic Transformation of Fibroblast Cells |...
Although TGF-β has been shown to stimulate the growth of many fibroblast cell lines, only murine AKR-2B and NRK fibroblasts undergo anchorage-independent growth in response to TGF-β (29, 37). So far, the intracellular signaling pathway that mediates this transforming activity in the two fibroblast cell lines has not been clearly defined. Here we showed that SnoN is a critical mediator of TGF-β-induced transformation in AKR-2B and NRK fibroblast cells. TGF-β, through the action of the Smad2/Smad4 complex, induces a strong and prolonged upregulation of snoN expression in these fibroblast cells that lasts for more than 8 to 24 h. This sustained activation of snoN expression may be necessary for the anchorage-independent growth of these fibroblasts in response to TGF-β1, since reduction of snoN expression by siRNA abolished TGF-β-induced transformation of AKR-2B cells and shortening of the duration of snoN induction by a pharmacological inhibitor markedly impaired TGF-β-induced transformation ...
https://mcb.asm.org/content/25/24/10731.full
Projects in detail | Kantonsspital St.GallenProjects in detail | Kantonsspital St.Gallen
Cirrhosis of the liver is a condition with a high mortality and raising prevalence worldwide. Infectious complications are highly frequent and independent predictors of outcome in patients with cirrhosis - being the leading cause of decompensation, acute-on-chronic liver failure (ACLF) and death. There is no treatment option other than transplantation, applicable at early stages and to only a minority of patients. Susceptibility to infection has been documented in patients with cirrhosis and has been attributed to immuneparesis and monocyte dysfunction in the state of decompensation and liver failure. The underlying mechanisms are incompletely understood. Development of targeted immunomodulatory strategies might effectively reduce infectious complications and mortality in cirrhosis. MER receptor tyrosine kinase (MERTK), expressed on monocytes/macrophages, plays a pivotal role in dampening innate immune responses. We have recently discovered and documented the role of MERTK in innate immune ...
https://www.kssg.ch/mfz-19
Supplement to Tumor Progression Locus 2 (TPL2) Regulates Obesity-Associated Inflammation and Insulin Resistance | DiabetesSupplement to Tumor Progression Locus 2 (TPL2) Regulates Obesity-Associated Inflammation and Insulin Resistance | Diabetes
James W. Perfield, Yunkyoung Lee, Gerald I. Shulman, Varman T. Samuel, Michael J. Jurczak, Eugene Chang, Chen Xie, Phillip N. Tsichlis, Martin S. Obin, Andrew S. Greenberg ...
http://diabetes.diabetesjournals.org/content/suppl/2012/04/02/db10-0715.DC1
Recombinant Human FYN Protein, Myc/DDK-tagged, C13 and N15-labeled FYN-3213H - Creative BioMart
Purified Recombinant Human FYN Protein, Myc/DDK-tagged, C13 and N15-labeled from Creative Biomart. Recombinant Human FYN Protein, Myc/DDK-tagged, C13 and N15-labeled can be used for research.
https://www.creativebiomart.net/recombinant-human-fyn-protein-mycddk-tagged-c13-and-n15-labeled-514103.htm
BirdBase
tyrosine-protein kinase Fyn,FYN oncogene related to SRC, FGR, YES,c-fyn, fyn proto-oncogene,p59-Fyn,proto-oncogene c-Fyn,proto-oncogene tyrosine-protein kinase ...
http://birdbase.arizona.edu/birdbase/gene.jsp?birdbase_id=3844
gnocl::toggleButton - GNOCL Tcl/GTk Bindingsgnocl::toggleButton - GNOCL Tcl/GTk Bindings
Tcl script which is executed in the global scope if the show-help signal is received, which is normally the case if the user presses F1 or Ctrl-F1. Before evaluation the following percent strings are substituted: %w widget ...
https://sites.google.com/site/gnocltclgtk/gnocl-user-documentation/buttons/gnoc
Tcl1抗体|Abcam中国|Anti-Tcl1抗体(ab32813)Tcl1抗体|Abcam中国|Anti-Tcl1抗体(ab32813)
Tcl1兔多克隆抗体(ab32813)可与人样本反应并经WB实验严格验证，被1篇文献引用。中国75%以上现货，所有产品均提供质保服务，可通过电话、电邮或微信获得本地专属技术支持。
http://www.abcam.cn/tcl1-antibody-ab32813.html
Pbx3抗体|Abcam中国|Anti-Pbx3抗体(ab56239)Pbx3抗体|Abcam中国|Anti-Pbx3抗体(ab56239)
Pbx3兔多克隆抗体(ab56239)可与人样本反应并经WB, IHC实验严格验证，被1篇文献引用并得到1个独立的用户反馈。所有产品均提供质保服务，中国75%以上现货。
http://www.abcam.cn/pbx3-antibody-ab56239.html
SANDARINTOJASSANDARINTOJAS
Sandarintojas. Didžiausias pasirinkimas, greitas pristatymas. Didmeninė ir mažmeninė prekyba Signeda - didžiausia Baltijos šalyse žibintais prekiaujanti įmonė.
https://www.signeda.lt/d2r-xenon-lemputes-dalys-ml1687/d2r-xenon-lemputes-aksesuarai-c1336/d2r-xenon-lemputes-autochemija-c1343/d2r-xenon-lemputes-sandarintojas-c1524
Browsing Anatomy and Cell Biology by Subject Axl receptor tyrosine kinaseBrowsing Anatomy and Cell Biology by Subject Axl receptor tyrosine kinase
Mice lacking the Axl receptor tyrosine kinase (RTK) and its family members exhibit detrimental effects on their reproductive ability. AXL is localized to Sertoli cells, which are the major nurturing cells in the seminiferous ...
https://thescholarship.ecu.edu/handle/10342/75/browse?type=subject&value=Axl+receptor+tyrosine+kinase
Tumor progression locus 2 ablation suppressed hepatocellular carcinoma development by inhibiting hepatic...
Li, Xinli, Chun Liu, Blanche C. Ip, Kang-Quan Hu, Donald E. Smith, Andrew S. Greenberg, and Xiang-Dong Wang. Tumor progression locus 2 ablation suppressed hepatocellular carcinoma development by inhibiting hepatic inflammation and steatosis in mice. Journal of Experimental & Clinical Cancer Research 34, no. 1 (12, 2015): 1-8 ...
https://dl.tufts.edu/catalog/tufts:17545
AP-2α regulates migration of GN-11 neurons via a specific genetic programme involving the Axl receptor tyrosine kinase | BMC...AP-2α regulates migration of GN-11 neurons via a specific genetic programme involving the Axl receptor tyrosine kinase | BMC...
Neuronal migration is a crucial process that allows neurons to reach their correct target location to allow the nervous system to function properly. AP-2α is a transcription factor essential for neural crest cell migration and its mutation results in apoptosis within this cell population, as demonstrated by genetic models. We down-modulated AP-2α expression in GN-11 neurons by RNA interference and observe reduced neuron migration following the activation of a specific genetic programme including the Adhesion Related Kinase (Axl) gene. We prove that Axl is able to coordinate migration per se and by ChIP and promoter analysis we observe that its transcription is directly driven by AP-2α via the binding to one or more functional AP-2α binding sites present in its regulatory region. Analysis of migration in AP-2α null mouse embryo fibroblasts also reveals an essential role for AP-2α in cell movement via the activation of a distinct genetic programme. We show that AP-2α plays an essential role in cell
https://bmcbiol.biomedcentral.com/articles/10.1186/1741-7007-7-25/tables/2
AXL (AXL receptor tyrosine kinase) - KOMP (Knockout Mouse Project)
The KOMP Repository Collection is located at the MMRRC at the University of California, Davis and Childrens Hospital Oakland Research Institute. Question? Comments? For Mice, Cells, and germplasm please contact us at [email protected], US 1-888-KOMP-MICE or International +1-530-752-KOMP, or for vectors [email protected] or +1-510-450-7917 ...
https://www.komp.org/geneinfo.php?geneid=27786
Expression of c-cbl proto-oncogene is modulated during differentiation but not during induction of proliferation<...
TY - JOUR. T1 - Expression of c-cbl proto-oncogene is modulated during differentiation but not during induction of proliferation. AU - Mushinski, J.F.. AU - Goodnight, J.. AU - Rudikoff, E.. AU - Morse Iii, H.C.. AU - Langdon, Wallace. PY - 1994. Y1 - 1994. M3 - Article. VL - 9. SP - 2489. EP - 2497. JO - Oncogene. JF - Oncogene. SN - 0950-9232. ER - ...
https://research-repository.uwa.edu.au/en/publications/expression-of-c-cbl-proto-oncogene-is-modulated-during-differenti
PDB: 3C5L
HEADER TRANSFERASE 31-JAN-08 3C5L TITLE POLO-LIKE KINASE 1 POLO BOX DOMAIN IN COMPLEX WITH PPHSPT TITLE 2 PEPTIDE COMPND MOL_ID: 1; COMPND 2 MOLECULE: SERINE/THREONINE-PROTEIN KINASE PLK1; COMPND 3 CHAIN: A; COMPND 4 FRAGMENT: POLO BOX 1, POLO BOX 2, UNP RESIDUES 373-593; COMPND 5 SYNONYM: POLO-LIKE KINASE 1, PLK-1, SERINE/THREONINE- COMPND 6 PROTEIN KINASE 13, STPK13; COMPND 7 EC: 2.7.11.21; COMPND 8 ENGINEERED: YES; COMPND 9 MOL_ID: 2; COMPND 10 MOLECULE: PEPTIDE; COMPND 11 CHAIN: B; COMPND 12 ENGINEERED: YES SOURCE MOL_ID: 1; SOURCE 2 ORGANISM_SCIENTIFIC: HOMO SAPIENS; SOURCE 3 ORGANISM_COMMON: HUMAN; SOURCE 4 ORGANISM_TAXID: 9606; SOURCE 5 GENE: PLK1, PLK; SOURCE 6 EXPRESSION_SYSTEM: ESCHERICHIA COLI; SOURCE 7 EXPRESSION_SYSTEM_TAXID: 562; SOURCE 8 EXPRESSION_SYSTEM_STRAIN: ROSETTA 2; SOURCE 9 EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID; SOURCE 10 EXPRESSION_SYSTEM_PLASMID: PET28A; SOURCE 11 MOL_ID: 2; SOURCE 12 SYNTHETIC: YES KEYWDS PLK1, POLO-LIKE KINASE 1, POLO BOX DOMAIN, PHOSPHOPEPTIDE, ...
http://www.genome.jp/dbget-bin/www_bget?pdb:3C5L
Proto-Oncogene Proteins c-pim-1 | Profiles RNSProto-Oncogene Proteins c-pim-1 | Profiles RNS
This graph shows the total number of publications written about Proto-Oncogene Proteins c-pim-1 by people in this website by year, and whether Proto-Oncogene Proteins c-pim-1 was a major or minor topic of these publications ...
https://profiles.wakehealth.edu/display/96697
Sample Page - Suppression of KRas-mutant cancer through the combined inhibition of KRASSample Page - Suppression of KRas-mutant cancer through the combined inhibition of KRAS
This is an example page. Its different from a blog post because it will stay in one place and will show up in your site navigation (in most themes). Most people start with an About page that introduces them to potential site visitors. It might say something like this:. ...
http://complextraitgenomics.com/sample-page/
Sequence DetailSequence Detail
pep:known chromosome:VEGA66:10:93247414:93311135:-1 gene:OTTMUSG00000033471 transcript:OTTMUST00000084101 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:Elk3 description:ELK3, member of ETS oncogene family ...
http://www.informatics.jax.org/sequence/OTTMUSP00000045274
Штаны Power Mens Sweatpants | Черный | PumaШтаны Power Mens Sweatpants | Черный | Puma
Штаны Power Mens Sweatpants от PUMA добавят вашему повседневному гардеробу немного яркости. Вдоль бокового шва - непревзойденный брендинг PUMA (повторяющаяся надпись), культовый логотип PUMA No. 1 воплощен в прорезиненном принте.
https://ru.puma.com/power-men-s-sweatpants-589397-01.html
BBC Brain Training Experiment: the Good, the Bad, the Ugly | SharpBrainsBBC Brain Training Experiment: the Good, the Bad, the Ugly | SharpBrains
You may already have read the hundreds of media articles today titled brain training doesnt work and similar, based on the BBC Brain Test Britain
https://sharpbrains.com/blog/2010/04/20/bbc-brain-training-experiment-the-good-the-bad-the-ugly/
Хиты продаж мужских товаров PUMA - купить в интернет-магазине PUMAХиты продаж мужских товаров PUMA - купить в интернет-магазине PUMA
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https://ru.puma.com/sportivnye-tovary-dlja-muzhchin/hity-prodazh.html?product_list_dir=desc&product_list_order=price&size=l
Freeride | Skis | Products | Voelkl U.S.A.Freeride | Skis | Products | Voelkl U.S.A.
How do I find the right ski? Im Original geändert SkifinderHow do I find the right ski?. 5 questions to find your perfect ski match!. > Start Ski Finder ...
https://www.voelkl.com/en-us/products/skis/freeride/?season=0/toni-riepler
BBC - Nature UK: Get involved online with Springwatch 2012!BBC - Nature UK: Get involved online with Springwatch 2012!
Well its that time of year again and Springwatch wouldnt be Springwatch without you, the audience. So heres how you can get involved...
http://www.bbc.co.uk/blogs/natureuk/2012/05/get-involved-online-with-sprin.shtml?postid=112694984
Mayan day of apocalypse arrives - BBC...Mayan day of apocalypse arrives - BBC...
The date believed by many to herald the end of the world according to the Mayan calendar arrives, with thousands of people gathered at ancient sites.
https://www.bbc.co.uk/news/world-20803579
今日片語 | 與BBC一起學英語 | Page 2今日片語 | 與BBC一起學英語 | Page 2
代表臺灣向國際廣播的中央廣播電臺，與全球影音浪潮一同並進，除推陳出新各類型廣播節目，也運用既有廣播資源，結合全新製播的影音及改版官網，以「加乘」概念，有聲有影地傳遞臺灣多元面貌。 央廣要讓閱聽眾在聽見臺灣同時，也透過影音廣播新媒體，一睹臺灣的美好。 央廣近年積極革新，除了提供兩岸聽友、網友豐富即時的新聞與優質的空中廣播節目，也透過各種專題網站，以及十種外語網站，將央廣的多元呈現更豐富的臺灣風貌 ...
https://elt.rti.org.tw/category/todays-phrase/page/2/?filter_by=random_posts
പൂമ - വിക്കിപീഡിയപൂമ - വിക്കിപീഡിയ
അമേരിക്കയിൽ കണ്ടു വരുന്ന, മാർജ്ജാരവർഗ്ഗത്തിൽപ്പെടുന്ന ഒരു വലിയ ജീവിയാണ്‌ പൂമ.(പുമ)[3] ഇംഗ്ലീഷ്:Puma. ഏറ്റവും അധികം പേരുകളുള്ള മൃഗം എന്ന ഗിന്നസ് റെക്കോഡുണ്ട് ഇതിന്. കൂഗർ, പാന്തർ, പ്യൂമ, മൗണ്ടൻ ലയൺ, മൗണ്ടൻ ക്യാറ്റ് തുടങ്ങി നാൽപ്പതോളം പേരുകളിൽ അറിയപ്പെടുന്നു. കടുവ, സിംഹം, ജാഗ്വർ എന്നിവക്ക് പിന്നിലായി പുലിക്കൊപ്പം പൂച്ച കുടുംബത്തിലെ ഏറ്റവും വലിയ നാലാമത്തെ ജീവിയാണ് പൂമ. എങ്കിലും ...
https://ml.wikipedia.org/wiki/%E0%B4%AA%E0%B5%82%E0%B4%AE
AXL receptor tyrosine kinase | definition of AXL receptor tyrosine kinase by Medical dictionaryAXL receptor tyrosine kinase | definition of AXL receptor tyrosine kinase by Medical dictionary
Looking for online definition of AXL receptor tyrosine kinase in the Medical Dictionary? AXL receptor tyrosine kinase explanation free. What is AXL receptor tyrosine kinase? Meaning of AXL receptor tyrosine kinase medical term. What does AXL receptor tyrosine kinase mean?
http://medical-dictionary.thefreedictionary.com/AXL+receptor+tyrosine+kinase
Urinary Neutrophil Gelatinase-Associated Lipocalin (uNGAL) in Invasive Cardiology - Tabular View - ClinicalTrials.govUrinary Neutrophil Gelatinase-Associated Lipocalin (uNGAL) in Invasive Cardiology - Tabular View - ClinicalTrials.gov
Diagnosis of acute kidney injury (AKI) relies on a late marker, namely serum creatinine (SCr). New biomarkers are considered for early and sensitive detection of CIN. In particular, uNGAL has been used for early detection of AKI in the emergency department, after cardiopulmonary bypass or following CM administration.. This study will be conducted to assess the possible value of urinary Neutrophil Gelatinase-Associated Lipocalin (uNGAL) as an early detector of contrast-induced nephropathy (CIN) in a large sized cohort of patients undergoing percutaneous coronary procedures (PCP) and whether or not uNGAL correlates with the volume of contrast medium (CM) used. ...
https://clinicaltrials.gov/ct2/show/record/NCT01612117
The nature and discriminatory value of urinary neutrophil gelatinase-associated lipocalin in critically ill patients at risk of...The nature and discriminatory value of urinary neutrophil gelatinase-associated lipocalin in critically ill patients at risk of...
Different molecular forms of urinary neutrophil gelatinase-associated lipocalin (NGAL) have recently been discovered. We aimed to explore the nature, source and discriminatory value of urinary NGAL in
https://link.springer.com/article/10.1007%2Fs00134-013-3040-7
Investigation of urinary neutrophil gelatinase-associated lipocalin concentration for the diagnosis of ischaemia-reperfusion...Investigation of urinary neutrophil gelatinase-associated lipocalin concentration for the diagnosis of ischaemia-reperfusion...
Acute kidney injury (AKI) is a devastating potential consequence of renal ischaemia and reperfusion (I-R) subsequent to severe intra-operative hypotension and fluid resuscitation. Acute tubular epithelial damage is a common early histological abnormality in this syndrome. The high mortality rate associated with AKI in dogs is attributed in part to the limitations of current diagnostic techniques that can only detect AKI in the late stages when damage is irreversible. Early detection of renal tubular injury could improve outcome and might be possible by measuring urinary neutrophil gelatinase-associated lipocalin concentration (uNGAL) in at-risk dogs.. The objectives of this study were to establish a clinically relevant canine model of renal I-R injury, and use this model to determine changes in uNGAL within three hours of initiation of injury.. A pilot study was performed to establish the severity and duration of hypotension caused by haemorrhage, and duration of reperfusion, that produced ...
http://researchrepository.murdoch.edu.au/id/eprint/29818/
Neutrophil gelatinase-associated lipocalin regulates gut microbiota of mice<...
TY - JOUR. T1 - Neutrophil gelatinase-associated lipocalin regulates gut microbiota of mice. AU - Mori, Katsuya. AU - Suzuki, Takeshi. AU - Minamishima, Shizuka. AU - Igarashi, Toru. AU - Inoue, Kei. AU - Nishimura, Daisuke. AU - Seki, Hiroyuki. AU - Yamada, Takashige. AU - Kosugi, Shizuko. AU - Katori, Nobuyuki. AU - Hashiguchi, Saori. AU - Morisaki, Hiroshi. PY - 2016/1/1. Y1 - 2016/1/1. N2 - Background and Aim: Because neutrophil gelatinase-associated lipocalin (NGAL) is known to provide significant bacteriostatic effects during infectious conditions, we tested the hypothesis that this protein is up-regulated and secreted into the intraluminal cavity of the gut under critically ill conditions and is thus responsible for the regulation of bacterial overgrowth. Methods: With our institutional approval, male C57BL/6J mouse (6-7weeks) were enrolled and applied for lipopolysaccharide or peritonitis model compared with naïve control. We assessed NGAL protein concentrations in intestinal lumen and ...
https://keio.pure.elsevier.com/en/publications/neutrophil-gelatinase-associated-lipocalin-regulates-gut-microbio
Neutrophil gelatinase-associated lipocalin reflects the severity of renal impairment in subjects affected by chronic kidney...
Neutrophil gelatinase-associated lipocalin (NGAL) is a small 25-kDa protein released from kidney tubular cells after harmful stimuli. It represents one of the most promising future biomarkers in the diagnostic field of acute kidney injury (AKI), as the increase in NGAL levels is a good predictor of a brief-term onset of AKI, notably anticipating the resulting increase in serum creatinine. However, recent studies also suggest a possible role for NGAL in chronic kidney disease (CKD). For this reason we evaluated serum (sNGAL) and urinary NGAL (uNGAL) in a cohort of CKD patients in order to verify the relationship with the severity of renal impairment. In CKD patients sNGAL, uNGAL and the fractional excretion of this protein were notably increased as compared to controls. Furthermore both sNGAL and uNGAL were correlated with serum creatinine and, inversely, with residual glomerular filtration rate (GFR): this last relationship was found to be even closer than that found between GFR and serum ...
https://iris.unime.it/handle/11570/1858400
Lipocalin-2, human recombinant protein - Neutrophil gelatinase-associated lipocalin, NGAL, p25, 25 kDa alpha-2-microglobulin...Lipocalin-2, human recombinant protein - Neutrophil gelatinase-associated lipocalin, NGAL, p25, 25 kDa alpha-2-microglobulin...
Lipocalin-2, human recombinant protein, Neutrophil gelatinase-associated lipocalin, NGAL, p25, 25 kDa alpha-2-microglobulin-related subunit validated in (PBV10492r-10), Abgent
http://www.abgent.com/products/PBV10492r-Lipocalin-2-human-recombinant-protein
Plasma and urine neutrophil gelatinase-associated lipocalin in the diagnosis of new onset acute kidney injury in critically ill...Plasma and urine neutrophil gelatinase-associated lipocalin in the diagnosis of new onset acute kidney injury in critically ill...
Neutrophil gelatinase-associated lipocalin has been used for the diagnosis, prognosis and severity assessment of AKI and has been validated in paediatric populations (where comorbidity is low) and in conditions where the timing of the insult is clear (that is cardiac surgery and so on) [20-24]. Its role in an adult ICU population has not been well validated due to the heterogeneity and uncertainty of the timing of the insult. The pathophysiology and causes of AKI in the ICU could be indigenous [25] and may differ from pre-ICU causes (low-volume state, inotropes, contrast injury and so on). This has led to problems in the design and interpretation of studies in the general adult ICU patient cohort. In this study, we sought to overcome these problems by excluding patients with pre-existing chronic kidney disease (CKD) and/or AKI and by looking at the predictive value of both urinary and plasma NGAL at different time points following admission.. We found the incidence of AKI was 30.4% (n = 59) with ...
https://ccforum.biomedcentral.com/articles/10.1186/cc13958
Expression of neutrophil gelatinase-associated lipocalin in colorectal neoplastic progression : a marker of malignant potential?Expression of neutrophil gelatinase-associated lipocalin in colorectal neoplastic progression : a marker of malignant potential?
McLean , M H , Thomson , A J , Murray , G I , Fyfe , N , Hold , G L & El-Omar , E M 2013 , Expression of neutrophil gelatinase-associated lipocalin in colorectal neoplastic progression : a marker of malignant potential? , British Journal of Cancer , vol. 108 , no. 12 , pp. 2537-2541 . https://doi.org/10.1038/bjc. ...
https://aura-test.abdn.ac.uk/handle/2164/3477
Urinary Neutrophil Gelatinase-Associated Lipocalin Is Excellent Predictor of Acute Kidney Injury in Septic Elderly Patients
Abstract Elderly is the main age group affected by acute kidney injury (AKI). There are no studies that investigated the predictive properties of urinary (u) NGAL as an AKI marker in septic elderly population. This study aimed to evaluate the efficacy of uNGAL as predictor of AKI diagnosis and prognosis in elderly septic patients admitted to ICUs. We prospectively studied elderly patients with sepsis admitted to ICUs from October 2014 to November 2015. Assessment of renal function was performed daily by serum creatinine and urine output. The level of uNGAL was performed within the first 48 hours of the diagnosis of sepsis (NGAL1) and between 48 and 96 hours (NGAL2). The results were presented using descriptive statistics and area under the receiver operating characteristic curve (AUC-ROC) and p value was 5%. Seventy-five patients were included, 47 (62.7%) developed AKI. At logistic regression, chronic kidney disease and low mean blood pressure at admission were identified as factors associated ...
http://www.aginganddisease.org/EN/Y2018/V9/I2/182
Urinary neutrophil gelatinase-associated lipocalin as an early predictor of acute kidney injury in cardiac surgery patients |...Urinary neutrophil gelatinase-associated lipocalin as an early predictor of acute kidney injury in cardiac surgery patients |...
One-hundred and eighty-one patients (66.1%) were men; mean age was 68.2 ± 12.2 years. Valve replacement was performed in 123, coronary artery bypass graft (CABG) in 81, valve surgery + CABG in 48, cardiac transplant in five, aorta aneurism surgery in nine, and other procedures in eight patients. ICU and hospital stays were 6.7 ± 8.1 and 15.7 ± 13.9 days, respectively. Renal replacement therapy (RRT) was required in 16 patients (5.8%) within 48 hours of ICU stay and in 28 patients (10.2%) within 43weeks. Mortality at 28 days was 2.9%. Eighty-six patients (31.4%) were diagnosed with AKI within 48 hours of surgery. Area under the ROC curve of POST uNGAL for AKI diagnosis was 0.72 (0.66 to 0.79) (P 0.0001) at an optimal cutoff value of 1803 μg/l, with 78.7% specificity, 64% sensitivity and 74.1% accuracy. uNGAL advanced diagnosis of AKI in 44 patients (51.2%), whereas diagnosis was achieved at the same time as AKI criteria in 11 patients; AKI criteria outperformed uNGAL in only 36% of cases. ...
https://rd.springer.com/article/10.1186/cc12349
RAB41, member RAS oncogene family | definition of RAB41, member RAS oncogene family by Medical dictionaryRAB41, member RAS oncogene family | definition of RAB41, member RAS oncogene family by Medical dictionary
Looking for online definition of RAB41, member RAS oncogene family in the Medical Dictionary? RAB41, member RAS oncogene family explanation free. What is RAB41, member RAS oncogene family? Meaning of RAB41, member RAS oncogene family medical term. What does RAB41, member RAS oncogene family mean?
http://medical-dictionary.thefreedictionary.com/RAB41%2C+member+RAS+oncogene+family
Neutrophil gelatinase-associated lipocalin as an early indicator for postoperative renal failure - Semantic ScholarNeutrophil gelatinase-associated lipocalin as an early indicator for postoperative renal failure - Semantic Scholar
Semantic Scholar extracted view of Neutrophil gelatinase-associated lipocalin as an early indicator for postoperative renal failure by CD Van der Marel et al.
https://www.semanticscholar.org/paper/Neutrophil-gelatinase-associated-lipocalin-as-an-e-Marel-Geus/98f04924229a6b3cf67f8439f637a137bbd6f05b
Ron (human)Ron (human)
Alt. Names/Synonyms: c-met-related tyrosine kinase; CD136; CDw136; macrophage stimulating 1 receptor (c-met-related tyrosine kinase); Macrophage-stimulating protein receptor; Macrophage-stimulating protein receptor alpha chain; Macrophage-stimulating protein receptor beta chain; MSP receptor; MST1R; p185-Ron; Protein-tyrosine kinase 8; PTK8; PTK8 protein tyrosine kinase 8; RON; soluble RON variant 1; soluble RON variant 2; soluble RON variant 3; soluble RON variant 4 ...
https://www.phosphosite.org/proteinAction.action?id=1945
Anti-Human RON Antibody | Human RON Antibody | RON Antibody | MST1R AntibodyAnti-Human RON Antibody | Human RON Antibody | RON Antibody | MST1R Antibody
Macrophage stimulating 1 receptor (c-met-related tyrosine kinase), encoded by the MST1R gene, is a cell-surface receptor that binds macrophage-stimulating protein (MSP). It was previously known as RON. The precursor protein is cleaved to generate the mature form, a heterodimer of disulfide-linked alpha and beta subunits. The beta subunit of MST1R/RON is phosphorylated at tyrosine residues upon activation by MSP. MST1R/RON signaling activates the wound healing response by promoting epithelial cell migration, proliferation, and survival at the wound site. MST1R/RON is also known as CDw136, protein-tyrosine kinase 8 (PTK8), c-met-related tyrosine kinase, macrophage-stimulating protein receptor, MSP receptor, p185-Ron, CD136, MST1R variant RON30, MST1R variant RON62, and RON variant E2E3.. ...
http://www.clontech.com/US/Products/Cell_Biology_and_Epigenetics/Miscellaneous/Primary_Antibodies_L-Z/RON?sitex=10020:22372:US&PEBCL1=KxAx5kOsDF2KxVauNfTP5cRpDW&PEBCL1_pses=ZG2C7514F09686A061D850A0CBD4CF018B936AAB5D1F90831716ACFC33EE472D766E0B3EAFE9D9FEF6726D53AAD0AA2DE3C46E8C91E0D2ACEA
Anti-Human RON Antibody | Human RON Antibody | RON Antibody | MST1R AntibodyAnti-Human RON Antibody | Human RON Antibody | RON Antibody | MST1R Antibody
Macrophage stimulating 1 receptor (c-met-related tyrosine kinase), encoded by the MST1R gene, is a cell-surface receptor that binds macrophage-stimulating protein (MSP). It was previously known as RON. The precursor protein is cleaved to generate the mature form, a heterodimer of disulfide-linked alpha and beta subunits. The beta subunit of MST1R/RON is phosphorylated at tyrosine residues upon activation by MSP. MST1R/RON signaling activates the wound healing response by promoting epithelial cell migration, proliferation, and survival at the wound site. MST1R/RON is also known as CDw136, protein-tyrosine kinase 8 (PTK8), c-met-related tyrosine kinase, macrophage-stimulating protein receptor, MSP receptor, p185-Ron, CD136, MST1R variant RON30, MST1R variant RON62, and RON variant E2E3.. ...
http://www.clontech.com/US/Products/Cell_Biology_and_Epigenetics/Miscellaneous/Primary_Antibodies_L-Z/RON?sitex=10020:22372:US&PEBCL1=d9P9UJ8G1DU4v3A88jgf75BP8A&PEBCL1_pses=ZG07AA6B334DEB958FFBCA540064F1BA5529F08BB960C6539E3D5D616F1740DE18F508FB4E90B2BA654623B74F04BF3BD19A0BCD62C1710716
Sparrho | Neutrophil gelatinase-associated lipocalin as an early diagSparrho | Neutrophil gelatinase-associated lipocalin as an early diag
Subramanian Senthilkumaran, Ponniah Thirumalaikolundusubramanian, Namasivayam Elangovan Journal of Emergencies, Trauma, and Shock 2019 12(4):260-262 Backgrou
https://www.sparrho.com/item/neutrophil-gelatinase-associated-lipocalin-as-an-early-diagnostic-biomarker-of-acute-kidney-injury-in-snake-bite/24de6ee/
Significance of the entire C-terminus in biological activities mediated by the RON receptor tyrosine kinase and its oncogenic...Significance of the entire C-terminus in biological activities mediated by the RON receptor tyrosine kinase and its oncogenic...
The RON receptor tyrosine kinase regulates epithelial cell homeostasis and tumorigenesis by transducing multiple signals through its functional domains. The present study was to determine the significance of the entire C-terminus in RON or its variant RON160-mediated activities related to cell motility and tumorigenesis. Analysis of protein phosphorylation revealed that elimination of the entire C-terminus significantly impairs the ligand-dependent or independent RON or RON160 phosphorylation and dimerization. Phosphorylation of downstream signaling proteins such as Erk1/2, AKT, and p38 MAP kinase was also diminished in cells expressing the C-terminus-free RON or RON160. These dysfunctional activities were accompanied with the inability of truncated RON or RON160 to mediate cytoplasmic β-catenin accumulation. Functional analysis further demonstrated that truncation of the C-terminus significantly impairs RON or RON160-mediated cell proliferation, morphological changes, and cellular migration.
https://jeccr.biomedcentral.com/articles/10.1186/1756-9966-27-55
Expression Profiles of SnoN in Normal and Cancerous Human Tissues Support Its Tumor Suppressor Role in Human Cancer
SnoN is a negative regulator of TGF-β signaling and also an activator of the tumor suppressor p53 in response to cellular stress. Its role in human cancer is complex and controversial with both pro-oncogenic and anti-oncogenic activities reported. To clarify its role in human cancer and provide clinical relevance to its signaling activities, we examined SnoN expression in normal and cancerous human esophageal, ovarian, pancreatic and breast tissues. In normal tissues, SnoN is expressed in both the epithelium and the surrounding stroma at a moderate level and is predominantly cytoplasmic. SnoN levels in all tumor epithelia examined are lower than or similar to that in the matched normal samples, consistent with its anti-tumorigenic activity in epithelial cells. In contrast, SnoN expression in the stroma is highly upregulated in the infiltrating inflammatory cells in high-grade esophageal and ovarian tumor samples, suggesting that SnoN may potentially promote malignant progression through ...
http://connection.ebscohost.com/c/articles/87624005/expression-profiles-snon-normal-cancerous-human-tissues-support-tumor-suppressor-role-human-cancer
The protooncogene product, PEBP2β/CBFβ, is mainly located in the cytoplasm and has an affinity with cytoskeletal structures<...
TY - JOUR. T1 - The protooncogene product, PEBP2β/CBFβ, is mainly located in the cytoplasm and has an affinity with cytoskeletal structures. AU - Tanaka, Yuta. AU - Watanabe, Toshio. AU - Chiba, Natsuko. AU - Niki, Masaru. AU - Kuroiwa, Yasuyuki. AU - Nishihira, Tetsuro. AU - Satomi, Susumu. AU - Ito, Yoshiaki. AU - Satake, Masanobu. N1 - Funding Information: We thank Ms I Imamura for secretarial assistance. This investigation was supported in part by research grants from the Ministry of Education, Science and Culture of Japan, Proposal-Based Advanced Industrial Technology R&D Program, Takeda Science Foundation, The Ryoichi Naito Foundation for Medical Research, The Mochida Memorial Foundation for Medical and Pharmaceutical Research, Uehara Memorial Foundation and The Naito Foundation.. PY - 1997. Y1 - 1997. N2 - The Pebpb2/Cbfb gene encodes the non-DNA binding β subunit of the heterodimeric transcription factor, PEBP2/CBF, and has been implicated in a subtype of human acute myeloid leukemia, ...
https://tohoku.pure.elsevier.com/en/publications/the-protooncogene-product-pebp2%CE%B2cbf%CE%B2-is-mainly-located-in-the-cyt
Ly-6A is required for T cell receptor expression and protein tyrosine kinase fyn activity - Fingerprint - Yonsei UniversityLy-6A is required for T cell receptor expression and protein tyrosine kinase fyn activity - Fingerprint - Yonsei University
Fingerprint Dive into the research topics of Ly-6A is required for T cell receptor expression and protein tyrosine kinase fyn activity. Together they form a unique fingerprint. ...
https://yonsei.pure.elsevier.com/en/publications/ly-6a-is-required-for-t-cell-receptor-expression-and-protein-tyro/fingerprints/
Plus itPlus it
555 The Macrophage-Stimulating Protein receptor aka. MSP-R or RON belongs to the c-MET family of receptor tyrosine kinases. The ligand for c-MET - Hepatocyte Growth Factor (HGF) as well as RONs ligand, MSP are members of the kringle-domain plasminogen-related protein family. As its name implies, MSP was originally found to stimulate macrophages by a variety of means. For example, addition of MSP to certain RON-expressing macrophages induced shape changes, chemotaxis, macropinocytosis and phagocytosis. RON was also found to be expressed in epithelial cells such as keratinocytes where MSP was shown to phosphorylate RON and activate a number of signaling pathways that elicited cell adhesion/motility, anti-apoptotic and proliferative responses. Within the last few years, however, over-expression of RON has been observed in several epithelial tumors and cell lines (ex. colon, breast and lung). In addition, the oncogenic potential of RON was recently demonstrated following its overexpression in ...
http://cancerres.aacrjournals.org/content/65/9_Supplement/130.5
Mutagenetix > Incidental...Mutagenetix > Incidental...
FUNCTION: This gene encodes a precursor protein that is proteolytically cleaved to yield an alpha chain and a beta chain which form a membrane-spanning heterodimer. The encoded protein belongs to a family of cell-surface receptor tyrosine kinases involved in signaling from the cell surface to the intracellular environment. The binding of the encoded protein to its ligand, macrophage-stimulating protein, mediates several biological activities including wound healing, tumor immunity, macrophage activation and hematopoiesis as well as cell growth, motility, survival and adhesion. The protein encoded by this gene also functions in early development and the macrophage-mediated inflammatory response. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013 ...
https://mutagenetix.utsouthwestern.edu/incidental/incidental_rec.cfm?mid=364537
Proto-Oncogene Proteins c-ret - Medical Dictionary
Proto-Oncogene Proteins c-ret definition. define Proto-Oncogene Proteins c-ret. Explain Proto-Oncogene Proteins c-ret. What is Proto-Oncogene Proteins c-ret? Proto-Oncogene Proteins c-ret FAQ.
http://medicaldictionaryweb.com/Proto-Oncogene+Proteins+c-ret-definition/
ROS1 (ROS proto-oncogene 1 , receptor tyrosine kinase)ROS1 (ROS proto-oncogene 1 , receptor tyrosine kinase)
ROS1 (ROS proto-oncogene 1 , receptor tyrosine kinase), Authors: Samuel J Klempner, Sai-Hong Ou. Published in: Atlas Genet Cytogenet Oncol Haematol.
http://atlasgeneticsoncology.org/Genes/ROS1ID42144ch6q22.html
AKT/PKB signaling: navigating downstreamAKT/PKB signaling: navigating downstream
The serine/threonine kinase Akt, also known as protein kinase B (PKB), is a central node in cell signaling downstream of growth factors, cytokines, and other cellular stimuli. Aberrant loss or gain of Akt activation underlies the pathophysiological properties of a variety of complex diseases, includ …
https://pubmed.ncbi.nlm.nih.gov/17604717/?dopt=Abstract
TAM Receptor | TAM Receptor Tyrosine KinaseTAM Receptor | TAM Receptor Tyrosine Kinase
BMS-777607是一种Met相关的抑制剂，作用于c-Met，Axl，Ron和Tyro3，在无细胞试验中IC50分别为3.9 nM，1.1 nM，1.8 nM和4.3 nM，作用于Met相关靶点比作用于Lck， VEGFR-2，和TrkA/B选择性高40倍，比作用于其他受体和非受体激酶选择性高500多倍。Phase 1/2。. ...
https://www.selleck.cn/axl.html
Active Motif » TransAM Elk-1 (Elk-1, ETS oncogene family DNA binding ELISA)Active Motif » TransAM Elk-1 (Elk-1, ETS oncogene family DNA binding ELISA)
TransAM Elk-1 is a DNA-binding ELISA that quantifies the activated transcription factor using a method that is faster and more sensitive than gelshift, without radioactivity and gels.
https://www.activemotif.com/catalog/194/transam-elk-1
Plus itPlus it
Results: Of the 66 pts, 41 (62%) pts had wild-type (WT) KRAS and 25 (38%) pts harbored a KRAS mutation (codon 12 & 13). In the mutant KRAS group, 6 pts had SD (24%) and 19 pts had PD (76%) as their best OR; there were no responses. In the WT KRAS population, the PR rate was 12% (95% CI: 2 to 22), the SD rate was 54% (95% CI: 38 to 69), and the PD rate was 34% (95% CI: 20 to 49). The association between KRAS mutation status and lack of response to panitumumab was statistically significant (Fishers exact test, p = 0.003). From a Cox PH model, the hazard ratio for WT:mutant KRAS was 0.6 (95% CI: 0.34 to 0.95) for PFS and 0.5 (95% CI: 0.29 to 0.91) for OS. ...
http://mct.aacrjournals.org/content/6/11_Supplement/B114
Discovery and optimization of chromenotriazolopyrimidines as potent inhibitors of the mouse double minute 2-tumor protein 53...Discovery and optimization of chromenotriazolopyrimidines as potent inhibitors of the mouse double minute 2-tumor protein 53...
Tumor protein 53 (p53) is a critical regulator of cell cycle and apoptosis that is frequently disabled in human tumors. In many tumor types, p53 is deleted or mutated, but in others p53 is inactivated by overexpression or amplification of its negative regulator mouse double minute 2 (MDM2). A high-t …
https://pubmed.ncbi.nlm.nih.gov/19856920/
GtkRecentChooserDialog: GTK+ 2 Reference ManualGtkRecentChooserDialog: GTK+ 2 Reference Manual
GtkWidget *dialog; dialog = gtk_recent_chooser_dialog_new (Recent Documents, parent_window, GTK_STOCK_CANCEL, GTK_RESPONSE_CANCEL, GTK_STOCK_OPEN, GTK_RESPONSE_ACCEPT, NULL); if (gtk_dialog_run (GTK_DIALOG (dialog)) == GTK_RESPONSE_ACCEPT) { GtkRecentInfo *info; info = gtk_recent_chooser_get_current_item (GTK_RECENT_CHOOSER (dialog)); open_file (gtk_recent_info_get_uri (info)); gtk_recent_info_unref (info); } gtk_widget_destroy (dialog ...
http://www.manpagez.com/html/gtk2/gtk2-2.24.29/GtkRecentChooserDialog.php
BIM, BIM construction, BIM architecture, BIM software | A Listly ListBIM, BIM construction, BIM architecture, BIM software | A Listly List
A meeting place of worldwide BIM managers and BIM professionals to gather information regarding BIM, BIM software, BIM classes, BIM conference, BIM...
https://list.ly/list/1XaD-bim-bim-construction-bim-architecture-bim-software
Sequence DetailSequence Detail
pep:known chromosome:VEGA66:5:115631908:115647736:1 gene:OTTMUSG00000014704 transcript:OTTMUST00000034877 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:Rab35 description:RAB35 member RAS oncogene family ...
http://www.informatics.jax.org/sequence/OTTMUSP00000015590
MAS proto-oncogene antibody | acris-antibodies.com
The structure of MAS1 indicates that it belongs to the class of receptors that are coupled to GTP-binding proteins and share a conserved structural…
https://www.acris-antibodies.com/target/mas-proto-oncogene-antibody.htm
May 2018 - Newbioideas
A recent study from the Department of Cell Biology, University of Texas Southwestern Medical Center, Texas 75390, USA shows that XPO1 can be pharmacologically targeted in KRAS-mutant lung cancer. This study was... ...
http://newbioideas.com/2018/05/
BBC | Hakol SheliBBC | Hakol Sheli
The crisis at the BBC has been a long time coming and it will take far more than the resignation of George Entwistle to resolve it. That is because there is much more wrong at the BBC than just the problems highlighted by the Newsnight failings. Those failings have caused many people to wonder if…
https://hakolsheli.com/2012/11/18/bbc/
Addgene: pDONR223-MERTKAddgene: pDONR223-MERTK
Plasmid pDONR223-MERTK from Dr. William Hahns lab contains the insert MERTK and is published in Nature. 2010 Nov 24. ():. This plasmid is available through Addgene.
http://www.addgene.org/23900/
Völkl Ski & Travel Bags 2021 - 2022Völkl Ski & Travel Bags 2021 - 2022
How do I find the right ski? Im Original geändert SkifinderHow do I find the right ski?. 5 questions to find your perfect ski match!. > Start Ski Finder ...
https://www.voelkl.com/en-us/products/bags/?season=538
Doctor Who: 10 Things You May Not Know About Extremis | Anglophenia | BBC...Doctor Who: 10 Things You May Not Know About Extremis | Anglophenia | BBC...
In Extremis we find out a few unknown biological facts about the Doctor and Time Lords in general. We discover they have (or can...
http://www.bbcamerica.com/anglophenia/2017/05/doctor-who-10-things-you-may-not-know-about-extremis
DEK (gene)DEK (gene)
Alexiadis V, Waldmann T, Andersen J, Mann M, Knippers R, Gruss C (2000). "The protein encoded by the proto-oncogene DEK changes ... Kappes F, Burger K, Baack M, Fackelmayer FO, Gruss C (2001). "Subcellular localization of the human proto-oncogene protein DEK ... The human DEK gene encodes the DEK protein. This gene encodes a protein with one SAP domain. The protein binds to cruciform and ... PDBe-KB provides an overview of all the structure information available in the PDB for Human Protein DEK v t e (Genes on human ...
https://en.wikipedia.org/wiki/DEK_(gene)
N-MycN-Myc
... proto-oncogene protein also known as N-Myc or basic helix-loop-helix protein 37 (bHLHe37), is a protein that in humans is ... Ramsay G, Stanton L, Schwab M, Bishop JM (1987). "Human proto-oncogene N-myc encodes nuclear proteins that bind DNA". Mol. Cell ... This protein is located in the cell nucleus and must dimerize with another bHLH protein in order to bind DNA. N-Myc is highly ... "Identification and characterization of the protein encoded by the human N-myc oncogene". Science. 232 (4751): 768-72. Bibcode: ...
https://en.wikipedia.org/wiki/N-Myc
GNB1GNB1
Nishida K, Kaziro Y, Satoh T (1999). "Association of the proto-oncogene product dbl with G protein betagamma subunits". FEBS ... Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 is a protein that in humans is encoded by the GNB1 gene. ... Huang CL, Jan YN, Jan LY (1997). "Binding of the G protein betagamma subunit to multiple regions of G protein-gated inward- ... "Entrez Gene: GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1". Ogorodnikov A, Levin M, Tattikota S, ...
https://en.wikipedia.org/wiki/GNB1
MCF2MCF2
The DBL proto-oncogene is a protein that in humans is encoded by the MCF2 gene. The commonly-used name DBL is derived from " ... Nishida K, Kaziro Y, Satoh T (October 1999). "Association of the proto-oncogene product dbl with G protein betagamma subunits ... Ron D, Tronick SR, Aaronson SA, Eva A (August 1988). "Molecular cloning and characterization of the human dbl proto-oncogene: ... July 2000). "Human dbl proto-oncogene in 85 kb of xq26, and determination of the transcription initiation site". Gene. 253 (1 ...
https://en.wikipedia.org/wiki/MCF2
GNG2GNG2
Nishida K, Kaziro Y, Satoh T (1999). "Association of the proto-oncogene product dbl with G protein betagamma subunits". FEBS ... Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 is a protein that in humans is encoded by the GNG2 gene. ... Heterotrimeric G proteins play vital roles in cellular responses to external signals. The specificity of a G protein-receptor ... 2004). "A single Gbeta subunit locus controls cross-talk between protein kinase C and G protein regulation of N-type calcium ...
https://en.wikipedia.org/wiki/GNG2
HNRNPKHNRNPK
"Association of the vav proto-oncogene product with poly(rC)-specific RNA-binding proteins". Molecular and Cellular Biology. 15 ... RNA binding protein domains in other proteins that are similar to the RNA binding domain of protein K are called K-homology or ... Both proteins bind to single-stranded DNA as well as to RNA and can stimulate the activity of RNA polymerase II, the protein ... The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene is located in the ...
https://en.wikipedia.org/wiki/HNRNPK
MetencephalonMetencephalon
Wnt1 is a proto-oncogene protein (Wingless-type MMTV integration site family, member 1). This gene was originally thought to ... Fgf8 is also known as Fibroblast Growth Factor 8. It is a protein that is widely thought to be the most important organizing ...
https://en.wikipedia.org/wiki/Metencephalon
Testis-enhanced gene transfer familyTestis-enhanced gene transfer family
"Effects of antibiotics and a proto-oncogene homolog on destruction of protein translocator SecY". Science. 325 (5941): 753-6. ... Protein families, Membrane proteins, Transmembrane proteins, Transmembrane transporters, Transport proteins, Integral membrane ... the YccA protein of Escherichia coli and the YetJ protein of Bacillus subtilis. These proteins are about 200-250 residues in ... These proteins are distantly related to the ionotropic glutamate-binding protein of the N-methyl D-aspartate (NMDA) receptor of ...
https://en.wikipedia.org/wiki/Testis-enhanced_gene_transfer_family
FYNFYN
Proto-oncogene tyrosine-protein kinase Fyn (p59-FYN, Slk, Syn, MGC45350, Gene ID 2534) is an enzyme that in humans is encoded ... By definition as a proto-oncogene, Fyn codes for proteins that help regulate cell growth. Changes in its DNA sequence transform ... SH3 domain-mediated protein-protein interaction blocking drug". Oncogene. 21 (13): 2037-50. doi:10.1038/sj.onc.1205271. PMID ... Fyn is a member of the Src-family of kinases (SFK), the first proto-oncogene to be identified. The discovery of the Src-family ...
https://en.wikipedia.org/wiki/FYN
MYB (gene)MYB (gene)
Myb proto-oncogene protein is a member of the MYB (myeloblastosis) family of transcription factors. The protein contains three ... In humans, it includes Myb proto-oncogene like 1 and Myb-related protein B in addition to MYB proper. Members of the extended ... Jacobs SM, Gorse KM, Westin EH (1994). "Identification of a second promoter in the human c-myb proto-oncogene". Oncogene. 9 (1 ... MYB+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH) Drosophila Myb oncogene-like - The ...
https://en.wikipedia.org/wiki/MYB_(gene)
VAV1VAV1
Proto-oncogene vav is a protein that in humans is encoded by the VAV1 gene. The protein encoded by this proto-oncogene is a ... Shigematsu H, Iwasaki H, Otsuka T, Ohno Y, Arima F, Niho Y (May 1997). "Role of the vav proto-oncogene product (Vav) in ... Adams JM, Houston H, Allen J, Lints T, Harvey R (1992). "The hematopoietically expressed vav proto-oncogene shares homology ... Bustelo XR, Barbacid M (1992). "Tyrosine phosphorylation of the vav proto-oncogene product in activated B cells". Science. 256 ...
https://en.wikipedia.org/wiki/VAV1
CD135CD135
... is a proto-oncogene, meaning that mutations of this protein can lead to cancer. Mutations of the FLT3 receptor can lead ... Overview of all the structural information available in the PDB for UniProt: P36888 (Receptor-type tyrosine-protein kinase FLT3 ... Cluster of differentiation antigen 135 (CD135) also known as fms like tyrosine kinase 3 (FLT-3), receptor-type tyrosine-protein ... Cluster of differentiation cytokine receptor receptor tyrosine kinase tyrosine kinase oncogene hematopoiesis Lymphopoiesis# ...
https://en.wikipedia.org/wiki/CD135
FRAT1FRAT1
Proto-oncogene FRAT1 is a protein that in humans is encoded by the FRAT1 gene. The protein encoded by this gene belongs to the ... Jonkers J, Korswagen HC, Acton D, Breuer M, Berns A (Mar 1997). "Activation of a novel proto-oncogene, Frat1, contributes to ... Saitoh T, Mine T, Katoh M (2002). "Molecular cloning and expression of proto-oncogene FRAT1 in human cancer". Int. J. Oncol. 20 ... 2007). "FRAT1, a substrate-specific regulator of glycogen synthase kinase-3 activity, is a cellular substrate of protein kinase ...
https://en.wikipedia.org/wiki/FRAT1
Guanine nucleotide exchange factorGuanine nucleotide exchange factor
Raf is a proto-oncogene because mutations in this protein have been found in many cancers. The Rho GTPase Vav1, which can be ... GEFs are multi-domain proteins and interact with other proteins inside the cell through these domains. Adaptor proteins can ... G protein-coupled receptors are trans-membrane receptors that act as GEFs for their cognate G proteins upon binding of a ligand ... This 200 amino acid region is homologous to the yeast Sec7p protein. GEFs are often recruited by adaptor proteins in response ...
https://en.wikipedia.org/wiki/Guanine_nucleotide_exchange_factor
Tyrosine kinase 2Tyrosine kinase 2
1996). "Interaction of the c-cbl proto-oncogene product with the Tyk-2 protein tyrosine kinase". Biochem. Biophys. Res. Commun ... "The WD motif-containing protein RACK-1 functions as a scaffold protein within the type I IFN receptor-signaling complex". J. ... Non-receptor tyrosine-protein kinase TYK2 is an enzyme that in humans is encoded by the TYK2 gene. Tyk2 was the first member of ... This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by ...
https://en.wikipedia.org/wiki/Tyrosine_kinase_2
ZyxinZyxin
"SH3 domain-dependent interaction of the proto-oncogene product Vav with the focal contact protein zyxin". Oncogene. 12 (7): ... Degenhardt YY, Silverstein S (2001). "Interaction of Zyxin, a Focal Adhesion Protein, with the E6 Protein from Human ... SH3 domains of proteins involved in signal transduction pathways while the LIM domains are likely involved in protein-protein ... and characterization of a zyxin-related protein that binds the focal adhesion and microfilament protein VASP (vasodilator- ...
https://en.wikipedia.org/wiki/Zyxin
Open reading frameOpen reading frame
Interestingly, uORFs were found in two thirds of proto-oncogenes and related proteins. 64-75% of experimentally found ... Short ORFs (sORFs). Some short ORFs (sORFs) that lack the classical hallmarks of protein-coding genes (both from ncRNAs and ... If transcription were to cease before the stop codon, an incomplete protein would be made during translation. In eukaryotic ... Long ORFs are often used, along with other evidence, to initially identify candidate protein-coding regions or functional RNA- ...
https://en.wikipedia.org/wiki/Open_reading_frame
USP4USP4
Gupta K, Chevrette M, Gray DA (1994). "The Unp proto-oncogene encodes a nuclear protein". Oncogene. 9 (6): 1729-31. PMID ... 1995). "Elevated expression of Unph, a proto-oncogene at 3p21.3, in human lung tumors". Oncogene. 10 (11): 2179-83. PMID ... "Entrez Gene: USP4 ubiquitin specific peptidase 4 (proto-oncogene)". Gilchrist CA, Gray DA, Baker RT (December 1997). "A ... 2001). "The de-ubiquitinating enzyme Unp interacts with the retinoblastoma protein". Oncogene. 20 (39): 5538-5542. doi:10.1038/ ...
https://en.wikipedia.org/wiki/USP4
Src family kinaseSrc family kinase
Proto-oncogene tyrosine-protein kinase Src Myristoylation SH2 domain SH3 domain Parsons SJ, Parsons JT (October 2004). "Src ... It allows for weak protein-protein and protein-lipid interactions. Myristoylation aids in the membrane association of Src ... Src family kinases interact with many cellular cytosolic, nuclear and membrane proteins, modifying these proteins by ... Myristoylation and fusion proteins work together to localize Src to cellular membranes. Src kinases transduce signals related ...
https://en.wikipedia.org/wiki/Src_family_kinase
VAV3VAV3
1996). "SH3 domain-dependent interaction of the proto-oncogene product Vav with the focal contact protein zyxin". Oncogene. 12 ... "A proteomics strategy to elucidate functional protein-protein interactions applied to EGF signaling". Nat. Biotechnol. 21 (3): ... Guanine nucleotide exchange factor VAV3 is a protein that in humans is encoded by the VAV3 gene. This gene is a member of the ... The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin ...
https://en.wikipedia.org/wiki/VAV3
WNT3WNT3
Proto-oncogene protein Wnt-3 is a protein that in humans is encoded by the WNT3 gene. The WNT gene family consists of ... It encodes a protein showing 98% amino acid identity to mouse Wnt3 protein, and 84% to human WNT3A protein, another WNT gene ... These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate ... Smolich BD, McMahon JA, McMahon AP, Papkoff J (1994). "Wnt family proteins are secreted and associated with the cell surface". ...
https://en.wikipedia.org/wiki/WNT3
RELREL
The proto-oncogene c-Rel is a protein that in humans is encoded by the REL gene. The c-Rel protein is a member of the NF-κB ... "The v-rel oncogene product is complexed with cellular proteins including its proto-oncogene product and heat shock protein 70 ... "A human rel proto-oncogene cDNA containing an Alu fragment as a potential coding exon". Oncogene. 4 (7): 935-42. PMID 2666912. ... Kochel T, Rice NR (1992). "v-rel- and c-rel-protein complexes bind to the NF-kappa B site in vitro". Oncogene. 7 (3): 567-72. ...
https://en.wikipedia.org/wiki/REL
FER (gene)FER (gene)
Proto-oncogene tyrosine-protein kinase FER is an enzyme that in humans is encoded by the FER gene. Fer protein is a member of ... Kim, L; Wong T W (Sep 1998). "Growth factor-dependent phosphorylation of the actin-binding protein cortactin is mediated by the ... 1990). "The FER gene is evolutionarily conserved and encodes a widely expressed member of the FPS/FES protein-tyrosine kinase ... Lee ST, Strunk KM, Spritz RA (1993). "A survey of protein tyrosine kinase mRNAs expressed in normal human melanocytes". ...
https://en.wikipedia.org/wiki/FER_(gene)
ROS1ROS1
Proto-oncogene tyrosine-protein kinase ROS is an enzyme that in humans is encoded by the ROS1 gene. This proto-oncogene, highly ... The protein encoded by this gene is a type I integral membrane protein with tyrosine kinase activity. The protein may function ... protein; it is encoded by the c-ros oncogene and was first identified in 1986. The exact role of the ROS1 protein in normal ... Rabin M, Birnbaum D, Young D, Birchmeier C, Wigler M, Ruddle FH (July 1987). "Human ros1 and mas1 oncogenes located in regions ...
https://en.wikipedia.org/wiki/ROS1
MERTKMERTK
Proto-oncogene tyrosine-protein kinase MER is an enzyme that in humans is encoded by the MERTK gene. This gene is a member of ... "Entrez Gene: MERTK c-mer proto-oncogene tyrosine kinase". Iwase T, Tanaka M, Suzuki M, Naito Y, Sugimura H, Kino I (July 1993 ... "Ectopic expression of the proto-oncogene Mer in pediatric T-cell acute lymphoblastic leukemia". Clinical Cancer Research. 12 (9 ... Weier HU, Fung J, Lersch RA (Jun 1999). "Assignment of protooncogene MERTK (a.k.a. c-mer) to human chromosome 2q14.1 by in situ ...
https://en.wikipedia.org/wiki/MERTK
MYCLMYCL
L-myc-1 proto-oncogene protein is a protein that in humans is encoded by the MYCL1 gene. MYCL1 is a bHLH (basic helix-loop- ... Atchley WR, Fitch WM (1995). "Myc and Max: molecular evolution of a family of proto-oncogene products and their dimerization ... "Amplification and overexpression of the L-MYC proto-oncogene in ovarian carcinomas". Am. J. Pathol. 162 (5): 1603-10. doi: ... "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173-1178. Bibcode: ...
https://en.wikipedia.org/wiki/MYCL
Adapter molecule crkAdapter molecule crk
... also known as proto-oncogene c-Crk is a protein that in humans is encoded by the CRK gene. The CRK protein ... Crk Info with links in the Cell Migration Gateway Proto-Oncogene+Proteins+c-crk at the US National Library of Medicine Medical ... Koval AP, Karas M, Zick Y, LeRoith D (1998). "Interplay of the proto-oncogene proteins CrkL and CrkII in insulin-like growth ... 1993). "CRK proto-oncogene maps to human chromosome band 17p13". Oncogene. 8 (10): 2853-5. PMID 8378094. Smit L, van der Horst ...
https://en.wikipedia.org/wiki/Adapter_molecule_crk
IRS4IRS4
Koval, A P; Karas M; Zick Y; LeRoith D (Jun 1998). "Interplay of the proto-oncogene proteins CrkL and CrkII in insulin-like ... Koval AP, Karas M, Zick Y, LeRoith D (1998). "Interplay of the proto-oncogene proteins CrkL and CrkII in insulin-like growth ... The IRS4 protein is phosphorylated by the insulin receptor tyrosine kinase upon receptor stimulation. IRS4 has been shown to ... Tyrosine-phosphorylated IRS4 protein has been shown to associate with cytoplasmic signalling molecules that contain SH2 domains ...
https://en.wikipedia.org/wiki/IRS4
MOS (gene)MOS (gene)
Proto-oncogene serine/threonine-protein kinase mos is an enzyme that in humans is encoded by the MOS gene. MOS (gene) has been ... 1986). "Human proto-oncogene c-mos maps to 8q11". EMBO J. 4 (9): 2245-8. doi:10.1002/j.1460-2075.1985.tb03921.x. PMC 554492. ... 2004). "Proteins associated with type II bone morphogenetic protein receptor (BMPR-II) and identified by two-dimensional gel ... "Entrez Gene: MOS v-mos Moloney murine sarcoma viral oncogene homolog". Lenormand, J L; Benayoun B; Guillier M; Vandromme M; ...
https://en.wikipedia.org/wiki/MOS_(gene)
Reptilya, ang malayang ensiklopedyaReptilya, ang malayang ensiklopedya
... analyses of c-Jun and DJ-1 proto-oncogenes". Cytogenetic and Genome Research. 127 (2-4): 79-93. doi:10.1159/000297715. PMID ... "Sister group relationship of turtles to the bird-crocodilian clade revealed by nuclear DNA-coded proteins". Molecular Biology ...
https://tl.wikipedia.org/wiki/Reptilia
Onkogen, den frie encyklopædiOnkogen, den frie encyklopædi
Proto-oncogenes to Oncogenes to Cancer. Scitable by Nature Education Hentet fra "https://da.wikipedia.org/w/index.php?title= ... BRAF, gen for en protein kinase i signaltransduktionen med regulering af celledeling, differentiering m.m. ... Proto-onkogenRediger. Her er nogle eksempler på proto-onkogener, der ved aktivering bliver aktive onkogener: *RAS (HRAS, NRAS, ... en mutation, en virusinfektion eller miljøfaktorer (såkaldte carcinogener) aktiveres et proto-onkogen til et aktivt onkogen, ...
https://da.m.wikipedia.org/wiki/Oncogen
Proto-oncogene tyrosine-protein kinase SrcProto-oncogene tyrosine-protein kinase Src
... , also known as proto-oncogene c-Src, or simply c-Src (cellular Src; pronounced "sarc ... Proto-oncogene tyrosine-protein kinase Src) at the PDBe-KB. Portal: Biology (Articles with short description, Short description ... This proto-oncogene may play a role in the regulation of embryonic development and cell growth. When src is activated, it ... Eventually this normal gene mutated into an abnormally functioning oncogene within the Rous sarcoma virus. Once the oncogene is ...
https://en.wikipedia.org/wiki/Proto-oncogene_tyrosine-protein_kinase_Src
Papillary carcinomas of the breastPapillary carcinomas of the breast
... of neuroendocrine differentiation-related proteins such as the GDNF family of ligand proteins encoded by the RET proto-oncogene ... gene, ASCL1 protein encoded by the ASCL1 gene, Dok-7 protein encoded by the DOK7 gene, enolase 2 encoded by the ENOL2 gene, ... and HER2/neu protein (however, 46.4% of the cases were not tested for the HER2/neu). In a second histopathological study of 44 ... and HER2/neu protein. More resent reports find that these tumor cells strongly express the estrogen receptor in most cases and ...
https://en.wikipedia.org/wiki/Papillary_carcinomas_of_the_breast
PSMD7PSMD7
... as well as a number of proto-oncogenes (Raf, Myc, Myb, Rel, Src, Mos, ABL). The UPS is also involved in the regulation of ... To recognize protein as designated substrate, 19S complex has subunits that are capable to recognize proteins with a special ... Accordingly, misfolded proteins and damaged protein need to be continuously removed to recycle amino acids for new synthesis; ... The 19S regulatory particles can recognize ubiquitin-labeled protein as degradation substrate, unfold the protein to linear, ...
https://en.wikipedia.org/wiki/PSMD7
ABL (gene)ABL (gene)
The ABL1 proto-oncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell ... Activity of ABL1 protein is negatively regulated by its SH3 domain, and deletion of the SH3 domain turns ABL1 into an oncogene ... Tyrosine-protein kinase ABL1 also known as ABL1 is a protein that, in humans, is encoded by the ABL1 gene (previous symbol ABL ... Welch PJ, Wang JY (November 1993). "A C-terminal protein-binding domain in the retinoblastoma protein regulates nuclear c-Abl ...
https://en.wikipedia.org/wiki/ABL_(gene)
Promoter (genetics)Promoter (genetics)
Recent evidence also indicates that several genes (including the proto-oncogene c-myc) have G-quadruplex motifs as potential ... A connector protein dimer (e.g. CTCF or YY1) stabilizes the loop by anchoring one member on the enhancer and the other on the ... The loop is stabilized by a dimer of a connector protein (e.g. dimer of CTCF or YY1), with one member of the dimer anchored to ... The RNA transcript may encode a protein (mRNA), or can have a function in and of itself, such as tRNA or rRNA. Promoters are ...
https://en.wikipedia.org/wiki/Promoter_(genetics)
Axel UllrichAxel Ullrich
2009 Debrecen Award for Molecular Medicine 2009 Emanuel Merck Lectureship 2010 Wolf Prize research on human proto-oncogenes and ... Singapore Oncogenome Project at the Institute of Medical Biology aimed at identifying all oncogenic alterations in all protein ... investigation of the clinical relevance of the newly discovered PTK oncogenes which serves as basis for the development of ...
https://en.wikipedia.org/wiki/Axel_Ullrich
MYCMYC
... proto-oncogene, bHLH transcription factor is a protein that in humans is encoded by the MYC gene which is a member of the ... The protein contains basic helix-loop-helix (bHLH) structural motif. This gene is a proto-oncogene and encodes a nuclear ... Hilker M, Tellmann G, Buerke M, Moersig W, Oelert H, Lehr HA, Hake U (2001). "Expression of the proto-oncogene c-myc in human ... "MYC MYC proto-oncogene, bHLH transcription factor [ Homo sapiens (human) ]". Retrieved 2020-03-02. Dang CV, McGuire M, Buckmire ...
https://en.wikipedia.org/wiki/MYC
Glucocorticoid receptorGlucocorticoid receptor
... and proto-oncogenes in normal human osteoblast-like cells". Journal of Cellular Biochemistry. 50 (4): 411-424. doi:10.1002/jcb. ... the heat shock protein 70 (hsp70) and the protein FKBP4 (FK506-binding protein 4). The endogenous glucocorticoid hormone ... Hulkko SM, Wakui H, Zilliacus J (August 2000). "The pro-apoptotic protein death-associated protein 3 (DAP3) interacts with the ... resides in the cytosol complexed with a variety of proteins including heat shock protein 90 (hsp90), ...
https://en.wikipedia.org/wiki/Glucocorticoid_receptor
PSMB3PSMB3
... as well as a number of proto-oncogenes (Raf, Myc, Myb, Rel, Src, Mos, ABL). The UPS is also involved in the regulation of ... The eukaryotic proteasome recognizes degradable proteins, including damaged proteins for protein quality control purpose or key ... "Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes". ... This protein is one of the 17 essential subunits that contribute to the complete assembly of the 20S proteasome complex. In ...
https://en.wikipedia.org/wiki/PSMB3
LepidosauriaLepidosauria
... analyses of c-Jun and DJ-1 proto-oncogenes". Cytogenetic and Genome Research. 127 (2-4): 79-93. doi:10.1159/000297715. PMID ... "Sister group relationship of turtles to the bird-crocodilian clade revealed by nuclear DNA-coded proteins". Molecular Biology ...
https://en.wikipedia.org/wiki/Lepidosauria
HSPA8HSPA8
"The v-rel oncogene product is complexed with cellular proteins including its proto-oncogene product and heat shock protein 70 ... Heat shock 70 kDa protein 8 also known as heat shock cognate 71 kDa protein or Hsc70 or Hsp73 is a heat shock protein that in ... This protein binds to nascent polypeptides to facilitate correct protein folding. In order to properly fold non-native proteins ... This gene encodes a 70kDa heat shock protein which is a member of the heat shock protein 70 (Hsp70) family. As a Hsp70 protein ...
https://en.wikipedia.org/wiki/HSPA8
GFI1GFI1
"Mutations in proto-oncogene GFI1 cause human neutropenia and target ELA2". Nat. Genet. 34 (3): 308-12. doi:10.1038/ng1170. PMC ... Zinc finger protein Gfi-1 is a transcriptional repressor that in humans is encoded by the GFI1 gene. It is important normal ... GFI1+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH) This article incorporates text from ... Zweidler-Mckay PA, Grimes HL, Flubacher MM, Tsichlis PN (1996). "Gfi-1 encodes a nuclear zinc finger protein that binds DNA and ...
https://en.wikipedia.org/wiki/GFI1
Index of biochemistry articlesIndex of biochemistry articles
... proto-oncogene - proto-oncogene proteins - proto-oncogene protein C-kit - proto-oncogene proteins c-abl - proto-oncogene ... Proto-oncogene proteins c-fos - proto-oncogene proteins c-jun - proto-oncogene proteins c-mo - proto-oncogene proteins c-myc - ... protein - protein biosynthesis - Protein Data Bank - protein design - protein expression - protein folding - protein isoform - ... oncogene - oncogene protein - oncogene proteins V-abl - oncogenic retroviridae protein - open reading frame - opioid receptor ...
https://en.wikipedia.org/wiki/Index_of_biochemistry_articles
TelomeraseTelomerase
... activation of the Ras or myc proto-oncogenes, and aberration of the PP2A protein phosphatase. That is to say, the cell has an ... the time to senescence can be extended by inactivating the tumor suppressor proteins - p53 and Retinoblastoma protein (pRb). ... TERT proteins from many eukaryotes have been sequenced. By using TERC, TERT can add a six-nucleotide repeating sequence, 5'- ... The protein consists of four conserved domains (RNA-Binding Domain (TRBD), fingers, palm and thumb), organized into a "right ...
https://en.wikipedia.org/wiki/Telomerase
Primary effusion lymphomaPrimary effusion lymphoma
... is the cancer-causing MYC proto-oncogene although this overexpression, unlike the c-Myc overexpression occurring in other B- ... K1 protein which promotes the malignancy of host cells; 7) G-protein coupled receptor protein which promotes host cells' ... As detected by immunostaining methods, the malignant cells typically express molecular marker proteins such as CD45 (which is ... Potentially important examples include: 1) overexpression of the APOBEC3B gene whose protein product (termed "probable DNA dC-> ...
https://en.wikipedia.org/wiki/Primary_effusion_lymphoma
VXNVXN
... is flanked by alcohol dehydrogenase iron containing 1 and Myb proto-oncogene like 1. No human paralogs for VXN have been ... The isoelectric point of the protein is 10.42 which indicates the pH of the protein is basic. Vexin does contain a domain of ... Vexin is a protein encoded by VXN gene. VXN is found to be highly expressed in regions of the brain and spinal cord. VXN is ... The orthologs of vexin all show conservation of the SH3 protein domain family as well as a domain of unknown function (DUF4648 ...
https://en.wikipedia.org/wiki/VXN
TransactivationTransactivation
... a cellular proto-oncogene. HTLV, for instance, has been associated with causing leukemia primarily through this process. Its ... Transactivation can be triggered either by endogenous cellular or viral proteins, also called transactivators. These protein ... These two dopamine receptors can also regulate calcium channels through a direct protein-protein interaction in vivo ( ... receptor transactivation may result from the crosstalk of signaling cascades or the activation of G protein-coupled receptor ...
https://en.wikipedia.org/wiki/Transactivation
Epigenetic therapyEpigenetic therapy
... such as the MYC proto-oncogene, at some point in their development. For more information on the exact epigenetic changes which ... Histones are proteins which are involved in the folding and compaction of the chromatin. There are several different types of ... In general, DNA methylation attracts proteins which fold that section of the chromatin and repress the related genes. The ... epigenetic mechanisms to deactivate cellular antitumor systems and that most human cancers epigenetically activate oncogenes, ...
https://en.wikipedia.org/wiki/Epigenetic_therapy
Glutamate-rich protein 3Glutamate-rich protein 3
NCBI (April 2015). "MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase [ Homo sapiens (human) ]". {{cite journal}}: Cite ... Glutamate-rich protein 3, also known as Uncharacterized Protein C1orf173, is a protein encoded by the ERICH3 gene. ERICH3 was ... The C1orf173 protein has been predicted or experimentally observed to interact with the following proteins: CRISPLD2 GIMAP4 ... C1orf173 is predicted to be a nuclear protein based on PSORT II analysis and the suggested protein interactions found between ...
https://en.wikipedia.org/wiki/Glutamate-rich_protein_3
MECOMMECOM
EVI1 is a proto-oncogene conserved across humans, mice, and rats, sharing 91% homology in nucleotide sequence and 94% homology ... MDS1 and EVI1 complex locus protein EVI1 (MECOM) also known as ecotropic virus integration site 1 protein homolog (EVI-1) or ... EVI1 has been described as a proto-oncogene since its first discovery in 1988. Overexpression and aberrant expression of EVI1 ... as the likelihood of a random incorporation near a proto-oncogene was minimal. By 2008 it was realised that sites such as EVI1 ...
https://en.wikipedia.org/wiki/MECOM
OncogeneOncogene
Proto-oncogenes code for proteins that help to regulate the cell growth and differentiation. Proto-oncogenes are often involved ... a proto-oncogene becomes a tumor-inducing agent, an oncogene. Examples of proto-oncogenes include RAS, WNT, MYC, ERK, and TRK. ... Wikimedia Commons has media related to Proto-oncogene proteins. Drosophila Oncogenes and Tumor Suppressors - The Interactive ... The resultant protein encoded by an oncogene is termed oncoprotein. Oncogenes play an important role in the regulation or ...
https://en.wikipedia.org/wiki/Oncogene
EGR2EGR2
... multiple gene products and coregulation with the proto-oncogene c-fos". Molecular and Cellular Biology. 9 (2): 787-97. doi: ... Early growth response protein 2 is a protein that in humans is encoded by the EGR2 gene. EGR2 (also termed Krox20) is a ... multiple gene products and coregulation with the proto-oncogene c-fos". Molecular and Cellular Biology. 9 (2): 787-97. doi: ... The protein encoded by Krox20 contains two cys2his2-type zinc fingers. Krox20 gene expression is restricted to the early ...
https://en.wikipedia.org/wiki/EGR2
TransgeneTransgene
... which controls the transcription of the LMO2 proto-oncogene. Hybrid Fusion protein Gene pool Gene flow Introgression Nucleic ... a protein coding sequence (usually derived from the cDNA for the protein of interest), and a stop sequence. These are typically ... This non-native segment of DNA may either retain the ability to produce RNA or protein in the transgenic organism or alter the ... Transgenes are being used to produce milk with high levels of proteins or silk from the milk of goats. Another agricultural ...
https://en.wikipedia.org/wiki/Transgene
PSMD5PSMD5
... as well as a number of proto-oncogenes (Raf, Myc, Myb, Rel, Src, Mos, ABL). The UPS is also involved in the regulation of ... "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173-8. Bibcode:2005Natur. ... Lecossier D, Bouchonnet F, Clavel F, Hance AJ (2003). "Hypermutation of HIV-1 DNA in the absence of the Vif protein". Science. ... Such protein accumulation may contribute to the pathogenesis and phenotypic characteristics in neurodegenerative diseases, ...
https://en.wikipedia.org/wiki/PSMD5
Platelet-derived growth factorPlatelet-derived growth factor
Proto-Oncogene+Proteins+c-sis at the US National Library of Medicine Medical Subject Headings (MeSH) McKinnon RD, Matsui T, ... McClintock JT, Chan IJ, Thaker SR, Katial A, Taub FE, Aotaki-Keen AE, Hjelmeland LM (1992). "Detection of c-sis proto-oncogene ... The "c-Sis" oncogene is derived from PDGF. Age related downregulation of the PDGF receptor on islet beta cells has been ... It has been shown that the sis oncogene is derived from the PDGF B-chain gene. PDGF-BB is the highest-affinity ligand for the ...
https://en.wikipedia.org/wiki/Platelet-derived_growth_factor
GalNAc-T activation pathwayGalNAc-T activation pathway
... of GalNAc-Ts from the Golgi to the ER is believed to result from the activation of the proto-oncogene tyrosine-protein kinase ...
https://en.wikipedia.org/wiki/GalNAc-T_activation_pathway
PSMD14PSMD14
... as well as a number of proto-oncogenes (Raf, Myc, Myb, Rel, Src, Mos, Abl). The UPS is also involved in the regulation of ... Misfolded proteins and damaged protein need to be continuously removed to recycle amino acids for new synthesis; in addition, ... To recognize proteins as designated substrates, the 19S complex has subunits that are capable of recognizing proteins with a ... The 19S regulatory particles can recognize ubiquitin-labeled protein as a substrate for degradation, unfold the protein to a ...
https://en.wikipedia.org/wiki/PSMD14
MAS1L MAS1 proto-oncogene like, G protein-coupled receptor [Homo sapiens (human)] - Gene - NCBIMAS1L MAS1 proto-oncogene like, G protein-coupled receptor [Homo sapiens (human)] - Gene - NCBI
MAS1 proto-oncogene like, G protein-coupled receptorprovided by HGNC. Primary source. HGNC:HGNC:13961 See related. Ensembl: ... MAS1L MAS1 proto-oncogene like, G protein-coupled receptor [ Homo sapiens (human) ] Gene ID: 116511, updated on 22-Sep-2022 ... mas-related G-protein coupled receptor MRG. Names. MAS-R. MAS1 oncogene-like. MAS1-like. mas-related G protein-coupled MRG. ... mRNA and Protein(s) * NM_052967.2 → NP_443199.1 mas-related G-protein coupled receptor MRG ...
https://www.ncbi.nlm.nih.gov/gene/116511
Recombinant Human Met Proto-Oncogene Protein (MET Human Protein) Protein (MET Human Protein)
Proto-oncogene c-Met, Scatter factor receptor, SF receptor, Tyrosine-protein kinase Met, MET,HGFR, AUTS9, RCCP2. ... MET Human Protein (GWB-BSP533) , Alias: Hepatocyte growth factor receptor, HGF receptor, HGF/SF receptor, ... MET Human Protein (GWB-BSP533). Alias Symbols. Hepatocyte growth factor receptor, HGF receptor, HGF/SF receptor, Proto-oncogene ... Met Proto-Oncogene Human Recombinant produced in Insect cells amino acids 1039-1345. ...
https://www.genwaybio.com/protein/met-human-protein
Proto-Oncogene Proteins c-pim-1 | Profiles RNS
Proto-Oncogene Proteins c-pim-1*Proto-Oncogene Proteins c-pim-1 ... Proto-Oncogene Proteins c-bcr. *Proto-Oncogene Proteins c-pim-1 ... "Proto-Oncogene Proteins c-pim-1" by people in this website by year, and whether "Proto-Oncogene Proteins c-pim-1" was a major ... Protein-Serine-Threonine Kinases [D08.811.913.696.620.682.700]. *Proto-Oncogene Proteins c-pim-1 [D08.811.913.696.620.682. ... "Proto-Oncogene Proteins c-pim-1" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH ( ...
https://profiles.uchicago.edu/profiles/display/25896
Proto-Oncogene Proteins c-yes | Profiles RNS
"Proto-Oncogene Proteins c-yes" by people in this website by year, and whether "Proto-Oncogene Proteins c-yes" was a major or ... "Proto-Oncogene Proteins c-yes" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH ( ... Proto-Oncogene Proteins c-yes*Proto-Oncogene Proteins c-yes. *Proto Oncogene Proteins c yes ... Below are the most recent publications written about "Proto-Oncogene Proteins c-yes" by people in Profiles. ...
https://profiles.jefferson.edu/display/29233
ProViz - Myc proto-oncogene protein - MYC - P01106ProViz - Myc proto-oncogene protein - MYC - P01106
... for information about a given query protein. Data relevant to the protein like an alignment of homologues, linear motifs, post ... ProViz is an interactive protein exploration tool, which searches several databases ... relative to their position in the protein. ...
http://slim.icr.ac.uk/proviz/proviz.php?uniprot_acc=P01106&alignment=QFO&ali_start=57&ali_end=67
"Proto-Oncogene Proteins c-akt/*metabolism" | Glembotski...
"Proto-Oncogene Proteins c-akt/*metabolism". Regulation of cardiac hypertrophic signaling by prolyl isomerase Pin1.. RATIONALE: ... Although Akt is known to be a crucial signaling protein in the myocardium, the role of Pim-1 has been overlooked. Pim-1 ... RATIONALE: The recently discovered PHLPP-1 (PH domain leucine-rich repeat protein phosphatase-1) selectively dephosphorylates ...
https://www.glembotskilab.org/tag/proto-oncogene-proteins-c-akt/metabolism/
How do cells sense DNA lesions?How do cells sense DNA lesions?
Protein Serine-Threonine Kinases / metabolism * Proto-Oncogene Proteins c-ets / metabolism * Repressor Proteins / metabolism ... The protein kinases ATM and ATR, as well as their budding yeast orthologs Tel1 and Mec1, act as master regulators of the DDR. ... The initiating events in the DDR entail both DNA lesion recognition and assembly of protein complexes at the damaged DNA sites ...
https://pubmed.ncbi.nlm.nih.gov/32219379/
Oncogenic potential and normal function of the proto-oncogenes encoding protein-tyrosine kinases.<...
Oncogenic potential and normal function of the proto-oncogenes encoding protein-tyrosine kinases. Basic life sciences. 1990;52: ... Oncogenic potential and normal function of the proto-oncogenes encoding protein-tyrosine kinases. In: Basic life sciences. 1990 ... Oncogenic potential and normal function of the proto-oncogenes encoding protein-tyrosine kinases. / Yamamoto, T.; Akiyama, T.; ... Oncogenic potential and normal function of the proto-oncogenes encoding protein-tyrosine kinases.. ...
https://waseda.pure.elsevier.com/ja/publications/oncogenic-potential-and-normal-function-of-the-proto-oncogenes-en
MYCN gene: MedlinePlus GeneticsMYCN gene: MedlinePlus Genetics
The MYCN gene provides instructions for making a protein that plays an important role in the formation of tissues and organs ... N-myc proto-oncogene protein. *neuroblastoma MYC oncogene. *neuroblastoma-derived v-myc avian myelocytomatosis viral related ... The MYCN gene belongs to a class of genes known as oncogenes. When mutated, oncogenes have the potential to cause normal cells ... v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog. *v-myc avian myelocytomatosis viral related oncogene ...
https://medlineplus.gov/genetics/gene/mycn/
RAF proto-oncogene serine/threonine-protein kinase(RAF1) ELISA kit | Technique alternative | 01014587412 - RnaGrade
The product Assay kit for RAF proto-oncogene serine/threonine-protein kinase(RAF1) (ELISA) is intended to be used for research ... The product Assay kit for RAF proto-oncogene serine/threonine-protein kinase(RAF1) (ELISA)should be kept between two and eight ... Assay kit for RAF proto-oncogene serine/threonine-protein kinase(RAF1) (ELISA). ... Assay kit for RAF proto-oncogene serine/threonine-protein kinase(RAF1) (ELISA) ...
https://rnagrade.com/catalog/257966-bluegen-elisas/258727-raf-proto-oncogene-serine-threonine-protein-kinase-raf1-elisa-kit
1mbg.1 | SWISS-MODEL Template Library
MYB PROTO-ONCOGENE PROTEIN: A. SMTL:PDB. SMTL Chain Id:. PDB Chain Id:. A. A ...
https://swissmodel.expasy.org/templates/1mbg
Recombinant Human ErbB4/Her4 Fc Chimera Protein, CF 1131-ER-050: R&D SystemsRecombinant Human ErbB4/Her4 Fc Chimera Protein, CF 1131-ER-050: R&D Systems
Her4 protein (1131-ER) is manufactured by R&D Systems. Reproducible results in bioactivity assays. Learn More... ... Proto-oncogene-like protein c-ErbB-4; receptor tyrosine-protein kinase erbB-4; Tyrosine kinase-type cell surface receptor HER4 ... as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, ... Recombinant Proteins. Recombinant Human NRG1-beta 1/HRG1-beta 1 ECD Protein 377-HB ...
https://www.rndsystems.com/products/recombinant-human-erbb4-her4-fc-chimera-protein-cf_1131-er
Clinical, molecular, and prognostic correlates of number, type, and functional localization of TET2 mutations in chronic...Clinical, molecular, and prognostic correlates of number, type, and functional localization of TET2 mutations in chronic...
Proto-Oncogene Proteins / genetics* * Survival Rate * Young Adult Substances * Biomarkers, Tumor * DNA-Binding Proteins ...
https://pubmed.ncbi.nlm.nih.gov/31836856/
C-jun (Proto-oncogene c-Jun) ELISA Kit | Technique alternative | 01014302042 - c-Jun protein - c-jun.com
C-JUN PROTEIN. c-Jun (Cellular Jun) is a protein encoded by gene Jun, that participates in the cell cycle and apoptosis. There ... Click here to buy Human C-jun (Proto-oncogene c-Jun) ELISA Kit at gentaur.com ... Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal ...
http://c-jun.com/assays/4353-elabscience/4950-human-c-jun-proto-oncogene-c-jun-elisa-kit
IMSEAR at SEARO: CURCUMIN INHIBITS CARCINOGEN INDUCED C-HA-RAS AND C-FOS PROTO-ONCOGENES EXPRESSION, AND PROTEIN KINASE C...
CURCUMIN INHIBITS CARCINOGEN INDUCED C-HA-RAS AND C-FOS PROTO-ONCOGENES EXPRESSION, AND PROTEIN KINASE C ACTIVITY IN MOUSE SKIN ... The enhanced expression of ras and fos proto-oncogenes in skin tumors in DMBA and TPA-treated animals was decreased by dietary ... and cellular oncogene of Harvey rat sarcoma virus (c-Ha-ras) proteins in tumorous skin. This was compared with the non-tumorous ... Also, it was found that the curcumin inhibited protein kinase C (PKC) activities in mouse epidermal extracts in a dose ...
https://imsear.searo.who.int/handle/123456789/130623
Epigenetics & Nuclear Signaling Elisa | Gentaur Elisa Kits | US - UK & Europe SupplyEpigenetics & Nuclear Signaling Elisa | Gentaur Elisa Kits | US - UK & Europe Supply
Rat MYC (Myc proto-oncogene protein) ELISA Kit , G-EC-05716 MSRP: ... QuicKey Pro Human CRP (C-Reactive Protein) ELISA Kit , G-EC-06100 QuicKey Pro Human CRP (C-Reactive Protein) ELISA Kit , G-EC- ... Rat hs-CRP (high-sensitivity C-Reactive Protein) ELISA Kit , G-EC-05993 Rat hs-CRP (high-sensitivity C-Reactive Protein) ELISA ... Rabbit hs-CRP (high-sensitivity C-Reactive Protein) ELISA Kit , G-EC-06068 Rabbit hs-CRP (high-sensitivity C-Reactive Protein) ...
https://caslab.com/epigenetics-nuclear-signaling-elisa/
DeCS 2006 - Changed termsDeCS 2006 - Changed terms
Proto-Oncogene Protein c-met. Proto-Oncogene Proteins c-met. Proto-Oncogene Protein p21(ras). Proto-Oncogene Proteins p21(ras) ... Proto-Oncogene Protein pp60(c-src). Proto-Oncogene Proteins pp60(c-src). ... Proto-Oncogene Protein c-kit. Proto-Oncogene Proteins c-kit. ... Heat-Shock Proteins 90. HSP90 Heat-Shock Proteins. I-kappa B. I ... DNA-Binding Protein, Cyclic AMP-Responsive. Cyclic AMP Response Element-Binding Protein. ...
https://decs.bvs.br/I/rep_i2006.htm
MeSH BrowserMeSH Browser
Cellular Proto-Oncogene Proteins Proto Oncogene Proteins, Cellular Proto-Oncogene Products, Cellular c-onc Proteins Registry ... 91; was PROTO-ONCOGENE PROTEINS, CELLULAR 1986-90. Online Note. use PROTO-ONCOGENE PROTEINS to search PROTO-ONCOGENE PROTEINS, ... Oncogene Proteins, Viral [D12.776.624.664.520] * Proto-Oncogene Proteins [D12.776.624.664.700] * Bcl-2-Like Protein 11 [D12.776 ... Proteins [D12.776] * Neoplasm Proteins [D12.776.624] * Oncogene Proteins [D12.776.624.664] * Oncogene Proteins, Fusion [D12.776 ...
https://meshb.nlm.nih.gov/record/ui?ui=D011518
c-Ret-GFRα1c-Ret-GFRα1
Proto-oncogene tyrosine-protein kinase receptor Ret (RET). Target Class. Kinase. Family. Receptor Tyrosine Kinase. Official ...
https://www.discoverx.com/target-data-sheets/kinase/c-ret-gfr%ce%b11
Biblio | Page 2 | Linus Pauling Institute | Oregon State University
Proto-Oncogene Proteins c-akt. Zhang W-J, Wei H, Hagen T, Frei B. 2007. Alpha-lipoic acid attenuates LPS-induced inflammatory ... Protein Phosphatase 2. Smith AR, Visioli F, Frei B, Hagen TM. 2006. Age-related changes in endothelial nitric oxide synthase ... Protein Structure, Tertiary. Sowell J, Frei B, Stevens JF. 2004. Vitamin C conjugates of genotoxic lipid peroxidation products ... Protein Conformation. Sowell J, Frei B, Stevens JF. 2004. Vitamin C conjugates of genotoxic lipid peroxidation products: ...
https://lpi.oregonstate.edu/biblio?page=1&f%5Bauthor%5D=476&f%5Bkeyword%5D=P&o=asc&s=keyword
Chang-Bin Jing, Ph.D. | Harvard Catalyst Profiles | Harvard CatalystChang-Bin Jing, Ph.D. | Harvard Catalyst Profiles | Harvard Catalyst
Proto-Oncogene Proteins. 1. 2020. 4699. 0.320. Why? DNA-Binding Proteins. 1. 2020. 9800. 0.230. Why? ...
https://connects.catalyst.harvard.edu/Profiles/display/person/134551/network/researchareas/details
Colon Cancer Medication: Antineoplastic Agent, Antimetabolite (pyrimidine analog), Antidote, Folic Acid Antagonist,...Colon Cancer Medication: Antineoplastic Agent, Antimetabolite (pyrimidine analog), Antidote, Folic Acid Antagonist,...
... proto-oncogene tyrosine-protein kinase ROS1 (ROS1), and anaplastic lymphoma kinase (ALK). [176] ... Monoclonal antibody to programmed cell death-1 protein (PD-1); blocks the interaction between PD-1 and its ligands, PD-L1 and ... In tumor models, larotrectinib demonstrates antitumor activity in cells by activation of TRK proteins resulting from gene ... inappropriate activation of proteins in this pathway has been shown to occur in many cancers. ...
https://www.medscape.com/answers/277496-93264/which-medications-in-the-drug-class-antineoplastic-agent-alkylating-agent-are-used-in-the-treatment-of-colon-cancer
ROS1 Clinical Research Trials | CenterWatchROS1 Clinical Research Trials | CenterWatch
proto-oncogene tyrosine-protein kinase ros. recurrent non-small cell lung cancer ... c-ros oncogene 1 receptor,. ROS1. ), BRAF (V-raf murine sarcoma viral oncogene homolog B1, BRAF)and so on have clearly targeted ... A comparison of baseline tumor characteristics in oncogene-driven cancers to tumor characteristics after early response to ...
https://www.centerwatch.com/clinical-trials/listings/search/?q=ROS1&page=5
c-Myc Research Products: Novus Biologicalsc-Myc Research Products: Novus Biologicals
Class E basic helix-loop-helix protein 39. *c-Myc. *myc proto-oncogene protein ... encoded by the MYC proto-oncogene. c-Myc was first discovered as the cellular homolog of the retroviral v-Myc oncogene. c-Myc ... c-Myc - transcription factor and oncogene. c-Myc is a protein of the Myc family of transcription factors (c-Myc, B-Myc, L-Myc, ... c-Myc, a proto-oncogene, has documented involvement in cellular differentiation, cell growth, cell death and tumor formation. ...
https://www.novusbio.com/common-name/c-myc
Chapter 13 | HuGE 2010 | CDCChapter 13 | HuGE 2010 | CDC
HRAS (Harvey Rat Sarcoma Virus Proto-oncogene): H-ras1, a proto-oncogene that encodes a protein involved in mitogenic signal ... including proto-oncogene activation, genomic instability and chromosomal structural aberrations, or uracil misincorporation ... results in a long version of the VDR protein (T-allele or the "f" allele) or a protein shortened by three amino acids (C-allele ... Oncogene. 2008;27:234-243.. *. El-Omar EM, Ng MT, Hold GL. Polymorphisms in toll-like receptor genes and risk of cancer. ...
https://www.cdc.gov/genomics/resources/books/2010_huge/chap13.htm
Molecular Markers in Fine Needle Aspirates of the Thyroid​ | BlueCross BlueShield of South CarolinaMolecular Markers in Fine Needle Aspirates of the Thyroid​ | BlueCross BlueShield of South Carolina
The expanded mutation panel included NTRK and ALS fusions that have targeted therapies as well as proto-oncogenes TERT and RET ... BRAF (B-Raf proto-oncogene, serine/threonine kinase) (eg, colon cancer, melanoma), gene analysis, V600 variant(s) ... ThyGeNEXT (Interpace Diagnostics, Parsippany, NJ) is a specific oncogene, mutational panel that tests genetic alterations ... Proto-oncogene tyrosine-protein kinase Src. TBP. TATA-box binding protein. TERT ...
https://www.southcarolinablues.com/web/public/brands/medicalpolicy/external/external-policies/molecular-markers-in-fine-needle-aspirates-of-the-thyroid/
Cardamonin reduces chemotherapy resistance of colon cancer cells via the TSP50/NF‑κB pathway in vitroCardamonin reduces chemotherapy resistance of colon cancer cells via the TSP50/NF‑κB pathway in vitro
Bax, Bcl-2-associated X protein; c-MYC, Myc proto-oncogene protein; Oct4, octamer-binding transcription factor 4; DMSO, ... TSP50, testes-specific protease 50; NF-κB, nuclear factor-κB; Bax, Bcl-2-associated X protein; c-MYC, Myc proto-oncogene ... Myc proto-oncogene protein (c-MYC, sc-789, 1:1,000), octamer-binding transcription factor 4 (Oct4, sc-9081, 1:1,000), and ... Protein content was determined using the BCA method. A total of 50 µg protein per lane was separated by 8-10% SDS-PAGE and ...
https://www.spandidos-publications.com/10.3892/ol.2018.8580?text=fulltext
SCOPe 2.07: Domain d2bdja : 2bdj ASCOPe 2.07: Domain d2bdja : 2bdj A
PDB Compounds: (A:) Proto-oncogene tyrosine-protein kinase Src. SCOPe Domain Sequences for d2bdja_:. Sequence, based on SEQRES ... Protein c-src tyrosine kinase [56155] (3 species). PTK group; Src subfamily; non-membrane spanning protein tyrosine kinase. ... Class d: Alpha and beta proteins (a+b) [53931] (388 folds). *. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily ... Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins). members organized in the groups and subfamiles ...
http://scop.berkeley.edu/sunid=128338&ver=2.07
GenAge Human Genes: Chromosomal LocationGenAge Human Genes: Chromosomal Location
MDM2 proto-oncogene, E3 ubiquitin protein ligase. 210. 12q24. PTPN11. protein tyrosine phosphatase, non-receptor type 11. 19. ... RAD52 homolog, DNA repair protein. 147. 12q14.3-q1. MDM2. ...
https://genomics.senescence.info/genes/map.php?submit=Search+GenAge&chr=12
PhosphorylationHomologMutationReceptorSignal TransductionRecombinant proteinsCellular proteinsViralInhibitorsKinasesSerineApoptosisHematopoietic StemUbiquitin1995TumorReceptorsRegulatoryEpidermalModulateHomologousEndogenousSignalsHer2Binding ProteinsGenesELISAMurineSuperfamilyOncogenicFamily proteinsPotentTumorsConstitutivelySequenceSequencesZinc FingerTransmembraneInduces
Phosphorylation2
  • c-Myc is modified by glycosylation and phosphorylation and has been shown to interact with numerous proteins including SMAD2, SMAD3, LSD1/KDM1A, MAD, and Sp1 (1). (novusbio.com)
  • This process, called phosphorylation, leads to the activation of a series of proteins in multiple signaling pathways. (medlineplus.gov)
Homolog1
  • These include α1 acid glycoprotein, serum amyloid A, the C-reactive protein homolog pentraxin-3, the lipocalin 24p3, and a host of cytokines ( 17 ). (diabetesjournals.org)
Mutation3
  • More than 80 percent of individuals with systemic mastocytosis have a mutation in the KIT gene that replaces the protein building block (amino acid) aspartic acid with the amino acid valine at position 816 in the protein (Asp816Val or D816V). (medlineplus.gov)
  • By combining in vitro with in vivo models we try to understand the consequences of loss/mutation of key-components of the ubiquitin machinery and ways to counteract protein stability deregulation. (uni-wuerzburg.de)
  • The Nsun7 (A11337)-deletion mutation, causes reduction of its protein rate and associated with sperm motility defect in infertile men. (cdc.gov)
Receptor11
  • Predicted to enable G protein-coupled receptor activity. (nih.gov)
  • Predicted to be involved in G protein-coupled receptor signaling pathway. (nih.gov)
  • Mesenchymal epithelial transition factor (c-MET) is a proto-oncogenic receptor tyrosine kinase. (genwaybio.com)
  • The KIT gene provides instructions for making a member of a protein family called receptor tyrosine kinases. (medlineplus.gov)
  • also known as EC: 2.7.10.1, Proto-oncogene c-ErbB-1, Receptor tyrosine-protein kinase erbB-1) is encoded by the EGFR (also known as ERBB, ERBB1, HER1) gene (Gene ID: 1956) in human. (sigmaaldrich.com)
  • The guanine nucleotide exchange factor (GEF) Dbl targets Rho family proteins thereby stimulating their GDP/GTP exchange, and thus is believed to be involved in receptor-mediated regulation of the proteins. (embl.de)
  • However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. (genetex.com)
  • This medication gets combined with HER2 proto-oncogene which is a protein similar to the EGF receptor. (lybrate.com)
  • LY2801653 , also known as Merestinib, is a n orally available, small molecule inhibitor of the proto-oncogene c-Met (mesenchymal-epithelial transition, also known as hepatocyte growth factor receptor [HGFR]) with potential antineoplastic activity. (newdrugapprovals.org)
  • In familial pituitary adenoma patients it is common that no germline defects are found after screening of aryl hydrocarbon receptor interacting protein (AIP) and other genes known to underlie the condition, suggesting the existence of yet unknown predisposition genes. (ox.ac.uk)
  • 19 normal healthy in- receptor protein (CD117) that is structurally dividuals were recruited as a control group. (who.int)
Signal Transduction1
  • Normally mitosis (cell division) is a carefully regulated event, requiring the activation of one protein to activate another, in what is known as a signal transduction cascade. (ubc.ca)
Recombinant proteins1
  • CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. (rndsystems.com)
Cellular proteins1
  • Proto-oncogenes encode for normal cellular proteins involved in growth signalling pathways. (ubc.ca)
Viral1
  • These genes were named proto-oncogenes, and their viral, cancer-causing counterparts were called oncogenes. (ubc.ca)
Inhibitors1
Kinases2
  • The protein kinases ATM and ATR, as well as their budding yeast orthologs Tel1 and Mec1, act as master regulators of the DDR. (nih.gov)
  • Oncogenic potential and normal function of the proto-oncogenes encoding protein-tyrosine kinases. (elsevier.com)
Serine3
  • The product Assay kit for RAF proto-oncogene serine/threonine-protein kinase(RAF1) (ELISA) is intended to be used for research purposes only. (rnagrade.com)
  • The product Assay kit for RAF proto-oncogene serine/threonine-protein kinase(RAF1) (ELISA)should be kept between two and eight degrees Celsius to ensure the retention of the stability and reactivity of the reagents included in the kit. (rnagrade.com)
  • Serine protease, D- or L-serine arginine rich enzyme of serine threonine kinase with serine that is encoded by the codons UCU, UCC, UCA, UCG, AGU and AGC is an ɑ-amino acid that is used in the biosynthesis of proteins. (rnagrade.com)
Apoptosis5
  • c-Jun (Cellular Jun) is a protein encoded by gene Jun, that participates in the cell cycle and apoptosis. (c-jun.com)
  • Cardamonin significantly suppressed the growth of chemotherapy‑resistant colon cancer cells, induced apoptosis and promoted caspase‑3/9 activity and Bax protein expression in 5‑fluorouracil (5‑FU)‑resistant HCT‑116 cells. (spandidos-publications.com)
  • This includes over-production of a growth factor, constitutively active receptors or intermediary molecules, or increased expression of proteins that inhibit apoptosis. (ubc.ca)
  • Changes in the levels of cell regulatory proteins were observed thereafter, in particular, Chk2 was activated upon DNA cleavage initiated by the foregoing onset of apoptosis,and this correlated with the S phase cell arrest after 24 hours. (univie.ac.at)
  • It is a proto-oncogene located on the long arm of chromosome 17 and plays a key role in cell proliferation, differentiation, inhibition of apoptosis, and tumor progression. (jmgims.co.in)
Hematopoietic Stem1
  • KIT protein signaling is important for the development and function of certain cell types, including reproductive cells (germ cells), early blood cells (hematopoietic stem cells), white blood cells called mast cells, cells in the gastrointestinal tract called interstitial cells of Cajal (ICCs), and cells called melanocytes. (medlineplus.gov)
Ubiquitin2
  • This hypothesis is based on the observation that several E3 ubiquitin ligases are mutated or lost in a high proportion of human tumours and exert their function by regulating the protein stability of essential transcription factors, which also function as potent proto-oncogenes, like MYC, JUN, NICD1, CCNE1 and p63/∆Np63. (uni-wuerzburg.de)
  • ubiquitin protein ligase E3. (gsea-msigdb.org)
19953
  • 1990a, 1990b, 1995) reportaron un aumento de la proliferación celular en experimentos realizados utilizando células de un glioma cerebral, linfocitos humanos y células ováricas de Hámster. (rfcom.ca)
  • Los experimentos in Vivo de Lai y Singh (1995, 1996) ameritan especial atención, teniendo en cuenta el interés que despertaron. (rfcom.ca)
  • Rosiridin Diamantis 1995) mutational activation of the K-ras proto-oncogene (Malats 1995) and loss of cell-cycle regulation by mutations in CDK-INK4A (Yoshida 1995). (cancer-ecosystem.com)
Tumor2
  • The adenomatous polyposis coli ( APC ) gene is a tumor suppressor gene, and mutations resulting in loss of APC protein function are associated with carcinogenesis. (cdc.gov)
  • This may induce cell death in tumor cells overexpressing c-Met protein or expressing constitutively activated c-Met protein. (newdrugapprovals.org)
Receptors2
  • In contrast, receptors encoded by oncogenes do not require the regulatory step of ligand binding to be active. (ubc.ca)
  • Its activity is directed by intracellular signals mediated by various types of receptors such as G protein-coupled receptors. (embl.de)
Regulatory3
  • When proto-oncogenes mutate to become oncogenes they retain their functionality, but are no longer capable of responding to normal regulatory signals (see Figure 1). (ubc.ca)
  • Hence, oncogenes are typically mutated forms of regulatory proteins within these pathways. (ubc.ca)
  • A family of endogenous regulatory proteins that associate with RETINOBLASTOMA PROTEIN via a specific high-affinity binding domain. (musc.edu)
Epidermal2
  • Also, it was found that the curcumin inhibited protein kinase C (PKC) activities in mouse epidermal extracts in a dose dependent manner. (who.int)
  • The alpha and gamma subunits are members of the kallikrein protein family, and while the role of the alpha subunit is unknown, the gamma subunit is an epidermal growth factor (EGF) binding protein and has a role in the functions of the beta subunit. (intechopen.com)
Modulate3
  • Supramolecular chemistry has recently emerged as a promising way to modulate protein functions, but devising molecules that will interact with a protein in the desired manner is difficult as many competing interactions exist in a biological environment (with solvents, salts or different sites for the target biomolecule). (tue.nl)
  • We now show that lysine-specific molecular tweezers bind to a 14-3-3 adapter protein and modulate its interaction with partner proteins. (tue.nl)
  • A family of inhibitory proteins which bind to the REL PROTO-ONCOGENE PROTEINS and modulate their activity. (bvsalud.org)
Homologous3
  • The BCL-2 Database, BCL2DB, is a collection of sequence, structural and functional information about BCL-2 homologous and BH3-containing proteins, which are among the most studied in cell biology. (inserm.fr)
  • BCL-2 homologous proteins share a similar α-helical bundle fold (the BCL-2 domain), have up to four different BH motifs (BH1-BH4), and can be either anti-apoptotic (e.g. (inserm.fr)
  • All the other (non-BCL-2 homologous) proteins possessing a functional BH3 motif are pro-apoptotic (such as the BH3-only member BIM or the BH3 motif-containing protein Atg12) ( see nomenclature ). (inserm.fr)
Endogenous2
  • An amino acid that occurs in endogenous proteins. (drugbank.com)
  • The KDEL-tagged glycopeptides (approximately 10% of the endocytosed load) behaved like endogenous ER residents: they stayed intracellular, and their oligosaccharide side chains remained sensitive to endoglycosidase H. An option thus exists to extract ER residents even at the most distant pole of the Golgi stack, suggesting that sorting of resident from exported ER proteins may occur in a multistage process akin to fractional distillation. (ox.ac.uk)
Signals1
  • In this way the oncogene product is capable of always activating the pro-growth pathway in the absence of pro-growth signals. (ubc.ca)
Her26
  • HER2 antibody recognizes HER2 protein, also known as proto-oncogene Neu or ERBB2 (predicted molecular weight of 138 kDa). (genetex.com)
  • HER2 can heterodimerize with EGFR protein or homodimerize when it is present in high concentrations. (genetex.com)
  • Recombinant protein encompassing a sequence within the C-terminus region of human Her2 / ErbB2. (genetex.com)
  • Her2 / ErbB2 antibody detects Her2 / ErbB2 protein at cell membrane by immunohistochemical analysis. (genetex.com)
  • Her2 / ErbB2 antibody [C2C3], C-term detects Her2 / ErbB2 protein at cell membrane in human breast carcinoma by immunohistochemical analysis. (genetex.com)
  • It works on tumors known to overexpress the protein HER2/neu. (lybrate.com)
Binding Proteins4
  • The Rho family of GTP-binding proteins has been implicated in the regulation of various cellular functions including actin cytoskeleton-dependent morphological change. (embl.de)
  • Retinoblastoma Binding Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (musc.edu)
  • This graph shows the total number of publications written about "Retinoblastoma Binding Proteins" by people in this website by year, and whether "Retinoblastoma Binding Proteins" was a major or minor topic of these publications. (musc.edu)
  • Below are the most recent publications written about "Retinoblastoma Binding Proteins" by people in Profiles. (musc.edu)
Genes6
  • The MYCN protein regulates the activity of other genes by attaching (binding) to specific regions of DNA and controlling the first step of protein production (transcription). (medlineplus.gov)
  • The MYCN gene belongs to a class of genes known as oncogenes. (medlineplus.gov)
  • As a result, only half the normal amount of this protein is available to control the activity of specific genes during development. (medlineplus.gov)
  • Oncogenes are mutated genes that contribute to cancer development by disrupting a cell's ability to control its own growth and DNA repair mechanisms2,5. (ubc.ca)
  • When these genes become mutated as a result of exposure to chemicals, radiation, or other carcinogens, these genes are called oncogenes. (ubc.ca)
  • Moreover, ntl interacts with ppt and kny to synergistically regulate the posterior expression of the gene encoding bone morphogenetic protein 4 (bmp4) but not of other known T-box genes, fibroblast growth factor genes or caudal genes. (zfin.org)
ELISA5
  • Please visit and bookmark www.avivasysbio.com to find your antibodies, ELISA kits, proteins, and more! (genwaybio.com)
  • Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. (rnagrade.com)
  • In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. (rndsystems.com)
  • E05 478 566 350 170 or Enzyme-Linked Immunosorbent Assays,E05 478 566 350 170 or Enzyme-Linked Immunosorbent Assays,Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. (c-jun.com)
  • Description: A sandwich quantitative ELISA assay kit for detection of Mouse Tubulin Polymerization Promoting Protein (TPPP) in samples from tissue homogenates or other biological fluids. (1elisakits.com)
Murine1
  • Using the enhanced chemiluminescence Western blotting detection system (Amersham), we found a relative increase in the cellular oncogene of FBJ murine osteogenic sarcoma virus (c-fos) and cellular oncogene of Harvey rat sarcoma virus (c-Ha-ras) proteins in tumorous skin. (who.int)
Superfamily1
  • Like all members of the Ras superfamily, the Rho proteins cycle between active GTP-bound and inactive GDP-bound conformational states. (embl.de)
Oncogenic1
  • In its proto-oncogenic form it requires binding of the growth factor molecule to enable its kinase activity [3]. (ubc.ca)
Family proteins2
  • It does not share significant sequence homology with other subtypes of small G-protein GEF motifs such as the Cdc25 domain and the Sec7 domain, which specifically interact with Ras and ARF family small GTPases, respectively, nor with other Rho protein interactive motifs, indicating that the Dbl family proteins are evolutionarily unique. (embl.de)
  • A BCL-2-like protein that has a C-terminal BCL-2 homology (BH3) domain and forms heterodimers with other BCL-2 FAMILY PROTEINS. (nih.gov)
Potent1
  • Pyrrolidine dithiocarbamate is a potent antioxidant against hypochlorous acid-induced protein damage. (oregonstate.edu)
Tumors1
  • The enhanced expression of ras and fos proto-oncogenes in skin tumors in DMBA and TPA-treated animals was decreased by dietary curcumin. (who.int)
Constitutively2
  • As a result, the KIT protein and the signaling pathways are constantly turned on (constitutively activated), which increases the proliferation and survival of ICCs, leading to GIST formation. (medlineplus.gov)
  • This and other KIT gene mutations result in production of altered proteins that are constitutively activated. (medlineplus.gov)
Sequence2
  • It shares 50% sequence identity with EGFR protein, but involves different signaling pathways. (genetex.com)
  • Today, this protein group is formed by a family of BCL-2 homologs (which have phylogenetic relationships), and by a collection of evolutionarily and structurally unrelated proteins characterized by the presence of a region of local sequence similarity with BCL-2, termed the BH3 motif. (inserm.fr)
Sequences1
  • This hypothesis postulated that these DNA sequences encoded for proteins involved in cell proliferation. (ubc.ca)
Zinc Finger1
Transmembrane1
  • For this purpose, a CHO cell line expressing a c-myc-tagged version of the transmembrane protein TGN38--which cycles between the TGN and the cell surface--was generated. (ox.ac.uk)
Induces1
  • Furthermore, 1,25(OH) 2 D 3 increased myocyte protein levels and increased cell size, suggesting that it induces cardiac myocyte hypertrophy. (umn.edu)