AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesInformation Science
ProthrombinProthrombin TimeFactor VHypoprothrombinemiasBlood CoagulationFactor XaFactor XPartial Thromboplastin TimeFactor VaBlood Coagulation FactorsThrombinBlood Coagulation TestsThrombophiliaVitamin KThromboplastinBlood Coagulation Disorders1-Carboxyglutamic AcidVitamin K DeficiencyInternational Normalized RatioProtein CWarfarinAnticoagulantsAntithrombin IIIHemostasisFactor VIICoagulantsKringlesFibrinopeptide AFibrinogenPeptide FragmentsThrombin TimePhospholipidsProtein SLupus Coagulation InhibitorThrombosisEnzyme PrecursorsFactor IXHirudinsPhosphatidylserinesAntithrombinsVenous ThrombosisHemorrhagic DisordersCattleDisseminated Intravascular CoagulationActivated Protein C ResistanceCarbon-Carbon LigasesFibrinolysisSnake VenomsProtein PrecursorsDansyl CompoundsKineticsThromboembolismVitamin K 1Fibrin Fibrinogen Degradation ProductsFactor X DeficiencyFactor VIIaThrombelastographyHemorrhageAcenocoumarolElapid VenomsPlasma4-HydroxycoumarinsViper VenomsFibrinDicumarolBlood Coagulation Factor InhibitorsBinding SitesHeparinElectrophoresis, Polyacrylamide GelBothropsFreeze DryingEnzyme ActivationChromogenic CompoundsAntibodies, AntiphospholipidPlatelet CountAmino Acid SequenceProtein BindingFactor XIbeta 2-Glycoprotein IPoint MutationFactor VIIINitracrineFactor V Deficiency
Prothrombin
A plasma protein that is the inactive precursor of thrombin. It is converted to thrombin by a prothrombin activator complex consisting of factor Xa, factor V, phospholipid, and calcium ions. Deficiency of prothrombin leads to hypoprothrombinemia.
Prothrombin Time
Clotting time of PLASMA recalcified in the presence of excess TISSUE THROMBOPLASTIN. Factors measured are FIBRINOGEN; PROTHROMBIN; FACTOR V; FACTOR VII; and FACTOR X. It is used for monitoring anticoagulant therapy with COUMARINS.
Factor V
Heat- and storage-labile plasma glycoprotein which accelerates the conversion of prothrombin to thrombin in blood coagulation. Factor V accomplishes this by forming a complex with factor Xa, phospholipid, and calcium (prothrombinase complex). Deficiency of factor V leads to Owren's disease.
Hypoprothrombinemias
Absence or reduced levels of PROTHROMBIN in the blood.
Blood Coagulation
The process of the interaction of BLOOD COAGULATION FACTORS that results in an insoluble FIBRIN clot.
Factor Xa
Activated form of factor X that participates in both the intrinsic and extrinsic pathways of blood coagulation. It catalyzes the conversion of prothrombin to thrombin in conjunction with other cofactors.
Factor X
Storage-stable glycoprotein blood coagulation factor that can be activated to factor Xa by both the intrinsic and extrinsic pathways. A deficiency of factor X, sometimes called Stuart-Prower factor deficiency, may lead to a systemic coagulation disorder.
Partial Thromboplastin Time
The time required for the appearance of FIBRIN strands following the mixing of PLASMA with phospholipid platelet substitute (e.g., crude cephalins, soybean phosphatides). It is a test of the intrinsic pathway (factors VIII, IX, XI, and XII) and the common pathway (fibrinogen, prothrombin, factors V and X) of BLOOD COAGULATION. It is used as a screening test and to monitor HEPARIN therapy.
Factor Va
Activated form of factor V. It is an essential cofactor for the activation of prothrombin catalyzed by factor Xa.
Blood Coagulation Factors
Endogenous substances, usually proteins, that are involved in the blood coagulation process.
Thrombin
An enzyme formed from PROTHROMBIN that converts FIBRINOGEN to FIBRIN.
Blood Coagulation Tests
Laboratory tests for evaluating the individual's clotting mechanism.
Thrombophilia
A disorder of HEMOSTASIS in which there is a tendency for the occurrence of THROMBOSIS.
Vitamin K
A lipid cofactor that is required for normal blood clotting. Several forms of vitamin K have been identified: VITAMIN K 1 (phytomenadione) derived from plants, VITAMIN K 2 (menaquinone) from bacteria, and synthetic naphthoquinone provitamins, VITAMIN K 3 (menadione). Vitamin K 3 provitamins, after being alkylated in vivo, exhibit the antifibrinolytic activity of vitamin K. Green leafy vegetables, liver, cheese, butter, and egg yolk are good sources of vitamin K.
Thromboplastin
Constituent composed of protein and phospholipid that is widely distributed in many tissues. It serves as a cofactor with factor VIIa to activate factor X in the extrinsic pathway of blood coagulation.
Blood Coagulation Disorders
Hemorrhagic and thrombotic disorders that occur as a consequence of abnormalities in blood coagulation due to a variety of factors such as COAGULATION PROTEIN DISORDERS; BLOOD PLATELET DISORDERS; BLOOD PROTEIN DISORDERS or nutritional conditions.
1-Carboxyglutamic Acid
Found in various tissues, particularly in four blood-clotting proteins including prothrombin, in kidney protein, in bone protein, and in the protein present in various ectopic calcifications.
Vitamin K Deficiency
A nutritional condition produced by a deficiency of VITAMIN K in the diet, characterized by an increased tendency to hemorrhage (HEMORRHAGIC DISORDERS). Such bleeding episodes may be particularly severe in newborn infants. (From Cecil Textbook of Medicine, 19th ed, p1182)
International Normalized Ratio
System established by the World Health Organization and the International Committee on Thrombosis and Hemostasis for monitoring and reporting blood coagulation tests. Under this system, results are standardized using the International Sensitivity Index for the particular test reagent/instrument combination used.
Protein C
A vitamin-K dependent zymogen present in the blood, which, upon activation by thrombin and thrombomodulin exerts anticoagulant properties by inactivating factors Va and VIIIa at the rate-limiting steps of thrombin formation.
Warfarin
An anticoagulant that acts by inhibiting the synthesis of vitamin K-dependent coagulation factors. Warfarin is indicated for the prophylaxis and/or treatment of venous thrombosis and its extension, pulmonary embolism, and atrial fibrillation with embolization. It is also used as an adjunct in the prophylaxis of systemic embolism after myocardial infarction. Warfarin is also used as a rodenticide.
Anticoagulants
Agents that prevent clotting.
Antithrombin III
A plasma alpha 2 glycoprotein that accounts for the major antithrombin activity of normal plasma and also inhibits several other enzymes. It is a member of the serpin superfamily.
Hemostasis
The process which spontaneously arrests the flow of BLOOD from vessels carrying blood under pressure. It is accomplished by contraction of the vessels, adhesion and aggregation of formed blood elements (eg. ERYTHROCYTE AGGREGATION), and the process of BLOOD COAGULATION.
Factor VII
Heat- and storage-stable plasma protein that is activated by tissue thromboplastin to form factor VIIa in the extrinsic pathway of blood coagulation. The activated form then catalyzes the activation of factor X to factor Xa.
Coagulants
Agents that cause clotting.
Kringles
Triple-looped protein domains linked by disulfide bonds. These common structural domains, so-named for their resemblance to Danish pastries known as kringlers, play a role in binding membranes, proteins, and phospholipids as well as in regulating proteolysis. Kringles are also present in coagulation-related and fibrinolytic proteins and other plasma proteinases.
Fibrinopeptide A
Two small peptide chains removed from the N-terminal segment of the alpha chains of fibrinogen by the action of thrombin during the blood coagulation process. Each peptide chain contains 18 amino acid residues. In vivo, fibrinopeptide A is used as a marker to determine the rate of conversion of fibrinogen to fibrin by thrombin.
Fibrinogen
Plasma glycoprotein clotted by thrombin, composed of a dimer of three non-identical pairs of polypeptide chains (alpha, beta, gamma) held together by disulfide bonds. Fibrinogen clotting is a sol-gel change involving complex molecular arrangements: whereas fibrinogen is cleaved by thrombin to form polypeptides A and B, the proteolytic action of other enzymes yields different fibrinogen degradation products.
Peptide Fragments
Partial proteins formed by partial hydrolysis of complete proteins or generated through PROTEIN ENGINEERING techniques.
Thrombin Time
Clotting time of PLASMA mixed with a THROMBIN solution. It is a measure of the conversion of FIBRINOGEN to FIBRIN, which is prolonged by AFIBRINOGENEMIA, abnormal fibrinogen, or the presence of inhibitory substances, e.g., fibrin-fibrinogen degradation products, or HEPARIN. BATROXOBIN, a thrombin-like enzyme unaffected by the presence of heparin, may be used in place of thrombin.
Phospholipids
Lipids containing one or more phosphate groups, particularly those derived from either glycerol (phosphoglycerides see GLYCEROPHOSPHOLIPIDS) or sphingosine (SPHINGOLIPIDS). They are polar lipids that are of great importance for the structure and function of cell membranes and are the most abundant of membrane lipids, although not stored in large amounts in the system.
Protein S
The vitamin K-dependent cofactor of activated PROTEIN C. Together with protein C, it inhibits the action of factors VIIIa and Va. A deficiency in protein S; (PROTEIN S DEFICIENCY); can lead to recurrent venous and arterial thrombosis.
Lupus Coagulation Inhibitor
An antiphospholipid antibody found in association with systemic lupus erythematosus (LUPUS ERYTHEMATOSUS, SYSTEMIC;), ANTIPHOSPHOLIPID SYNDROME; and in a variety of other diseases as well as in healthy individuals. In vitro, the antibody interferes with the conversion of prothrombin to thrombin and prolongs the partial thromboplastin time. In vivo, it exerts a procoagulant effect resulting in thrombosis mainly in the larger veins and arteries. It further causes obstetrical complications, including fetal death and spontaneous abortion, as well as a variety of hematologic and neurologic complications.
Thrombosis
Formation and development of a thrombus or blood clot in the blood vessel.
Enzyme Precursors
Physiologically inactive substances that can be converted to active enzymes.
Factor IX
Storage-stable blood coagulation factor acting in the intrinsic pathway. Its activated form, IXa, forms a complex with factor VIII and calcium on platelet factor 3 to activate factor X to Xa. Deficiency of factor IX results in HEMOPHILIA B (Christmas Disease).
Hirudins
Single-chain polypeptides of about 65 amino acids (7 kDa) from LEECHES that have a neutral hydrophobic N terminus, an acidic hydrophilic C terminus, and a compact, hydrophobic core region. Recombinant hirudins lack tyr-63 sulfation and are referred to as 'desulfato-hirudins'. They form a stable non-covalent complex with ALPHA-THROMBIN, thereby abolishing its ability to cleave FIBRINOGEN.
Phosphatidylserines
Derivatives of phosphatidic acids in which the phosphoric acid is bound in ester linkage to a serine moiety. Complete hydrolysis yields 1 mole of glycerol, phosphoric acid and serine and 2 moles of fatty acids.
Antithrombins
Endogenous factors and drugs that directly inhibit the action of THROMBIN, usually by blocking its enzymatic activity. They are distinguished from INDIRECT THROMBIN INHIBITORS, such as HEPARIN, which act by enhancing the inhibitory effects of antithrombins.
Venous Thrombosis
The formation or presence of a blood clot (THROMBUS) within a vein.
Hemorrhagic Disorders
Spontaneous or near spontaneous bleeding caused by a defect in clotting mechanisms (BLOOD COAGULATION DISORDERS) or another abnormality causing a structural flaw in the blood vessels (HEMOSTATIC DISORDERS).
Cattle
Domesticated bovine animals of the genus Bos, usually kept on a farm or ranch and used for the production of meat or dairy products or for heavy labor.
Disseminated Intravascular Coagulation
A disorder characterized by procoagulant substances entering the general circulation causing a systemic thrombotic process. The activation of the clotting mechanism may arise from any of a number of disorders. A majority of the patients manifest skin lesions, sometimes leading to PURPURA FULMINANS.
Activated Protein C Resistance
A hemostatic disorder characterized by a poor anticoagulant response to activated protein C (APC). The activated form of Factor V (Factor Va) is more slowly degraded by activated protein C. Factor V Leiden mutation (R506Q) is the most common cause of APC resistance.
Carbon-Carbon Ligases
Enzymes that catalyze the joining of two molecules by the formation of a carbon-carbon bond. These are the carboxylating enzymes and are mostly biotinyl-proteins. EC 6.4.
Fibrinolysis
The natural enzymatic dissolution of FIBRIN.
Snake Venoms
Solutions or mixtures of toxic and nontoxic substances elaborated by snake (Ophidia) salivary glands for the purpose of killing prey or disabling predators and delivered by grooved or hollow fangs. They usually contain enzymes, toxins, and other factors.
Protein Precursors
Dansyl Compounds
Compounds that contain a 1-dimethylaminonaphthalene-5-sulfonyl group.
Kinetics
The rate dynamics in chemical or physical systems.
Thromboembolism
Obstruction of a blood vessel (embolism) by a blood clot (THROMBUS) in the blood stream.
Vitamin K 1
A family of phylloquinones that contains a ring of 2-methyl-1,4-naphthoquinone and an isoprenoid side chain. Members of this group of vitamin K 1 have only one double bond on the proximal isoprene unit. Rich sources of vitamin K 1 include green plants, algae, and photosynthetic bacteria. Vitamin K1 has antihemorrhagic and prothrombogenic activity.
Fibrin Fibrinogen Degradation Products
Soluble protein fragments formed by the proteolytic action of plasmin on fibrin or fibrinogen. FDP and their complexes profoundly impair the hemostatic process and are a major cause of hemorrhage in intravascular coagulation and fibrinolysis.
Factor X Deficiency
Blood coagulation disorder usually inherited as an autosomal recessive trait, though it can be acquired. It is characterized by defective activity in both the intrinsic and extrinsic pathways, impaired thromboplastin time, and impaired prothrombin consumption.
Factor VIIa
Activated form of factor VII. Factor VIIa activates factor X in the extrinsic pathway of blood coagulation.
Thrombelastography
Use of a thrombelastograph, which provides a continuous graphic record of the physical shape of a clot during fibrin formation and subsequent lysis.
Hemorrhage
Bleeding or escape of blood from a vessel.
Acenocoumarol
A coumarin that is used as an anticoagulant. Its actions and uses are similar to those of WARFARIN. (From Martindale, The Extra Pharmacopoeia, 30th ed, p233)
Elapid Venoms
Venoms from snakes of the family Elapidae, including cobras, kraits, mambas, coral, tiger, and Australian snakes. The venoms contain polypeptide toxins of various kinds, cytolytic, hemolytic, and neurotoxic factors, but fewer enzymes than viper or crotalid venoms. Many of the toxins have been characterized.
Plasma
The residual portion of BLOOD that is left after removal of BLOOD CELLS by CENTRIFUGATION without prior BLOOD COAGULATION.
4-Hydroxycoumarins
Substances found in many plants, containing the 4-hydroxycoumarin radical. They interfere with vitamin K and the blood clotting mechanism, are tightly protein-bound, inhibit mitochondrial and microsomal enzymes, and are used as oral anticoagulants.
Viper Venoms
Venoms from SNAKES of the viperid family. They tend to be less toxic than elapid or hydrophid venoms and act mainly on the vascular system, interfering with coagulation and capillary membrane integrity and are highly cytotoxic. They contain large amounts of several enzymes, other factors, and some toxins.
Fibrin
A protein derived from FIBRINOGEN in the presence of THROMBIN, which forms part of the blood clot.
Dicumarol
An oral anticoagulant that interferes with the metabolism of vitamin K. It is also used in biochemical experiments as an inhibitor of reductases.
Blood Coagulation Factor Inhibitors
Substances, usually endogenous, that act as inhibitors of blood coagulation. They may affect one or multiple enzymes throughout the process. As a group, they also inhibit enzymes involved in processes other than blood coagulation, such as those from the complement system, fibrinolytic enzyme system, blood cells, and bacteria.
Binding Sites
The parts of a macromolecule that directly participate in its specific combination with another molecule.
Heparin
A highly acidic mucopolysaccharide formed of equal parts of sulfated D-glucosamine and D-glucuronic acid with sulfaminic bridges. The molecular weight ranges from six to twenty thousand. Heparin occurs in and is obtained from liver, lung, mast cells, etc., of vertebrates. Its function is unknown, but it is used to prevent blood clotting in vivo and vitro, in the form of many different salts.
Electrophoresis, Polyacrylamide Gel
Electrophoresis in which a polyacrylamide gel is used as the diffusion medium.
Bothrops
A genus of poisonous snakes of the VIPERIDAE family. About 50 species are known and all are found in tropical America and southern South America. Bothrops atrox is the fer-de-lance and B. jararaca is the jararaca. (Goin, Goin, and Zug, Introduction to Herpetology, 3d ed, p336)
Freeze Drying
Method of tissue preparation in which the tissue specimen is frozen and then dehydrated at low temperature in a high vacuum. This method is also used for dehydrating pharmaceutical and food products.
Enzyme Activation
Conversion of an inactive form of an enzyme to one possessing metabolic activity. It includes 1, activation by ions (activators); 2, activation by cofactors (coenzymes); and 3, conversion of an enzyme precursor (proenzyme or zymogen) to an active enzyme.
Chromogenic Compounds
Colorless, endogenous or exogenous pigment precursors that may be transformed by biological mechanisms into colored compounds; used in biochemical assays and in diagnosis as indicators, especially in the form of enzyme substrates. Synonym: chromogens (not to be confused with pigment-synthesizing bacteria also called chromogens).
Antibodies, Antiphospholipid
Autoantibodies directed against phospholipids. These antibodies are characteristically found in patients with systemic lupus erythematosus (LUPUS ERYTHEMATOSUS, SYSTEMIC;), ANTIPHOSPHOLIPID SYNDROME; related autoimmune diseases, some non-autoimmune diseases, and also in healthy individuals.
Platelet Count
The number of PLATELETS per unit volume in a sample of venous BLOOD.
Amino Acid Sequence
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
Protein Binding
The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments.
Factor XI
Stable blood coagulation factor involved in the intrinsic pathway. The activated form XIa activates factor IX to IXa. Deficiency of factor XI is often called hemophilia C.
beta 2-Glycoprotein I
A 44-kDa highly glycosylated plasma protein that binds phospholipids including CARDIOLIPIN; APOLIPOPROTEIN E RECEPTOR; membrane phospholipids, and other anionic phospholipid-containing moieties. It plays a role in coagulation and apoptotic processes. Formerly known as apolipoprotein H, it is an autoantigen in patients with ANTIPHOSPHOLIPID ANTIBODIES.
Point Mutation
A mutation caused by the substitution of one nucleotide for another. This results in the DNA molecule having a change in a single base pair.
Factor VIII
Blood-coagulation factor VIII. Antihemophilic factor that is part of the factor VIII/von Willebrand factor complex. Factor VIII is produced in the liver and acts in the intrinsic pathway of blood coagulation. It serves as a cofactor in factor X activation and this action is markedly enhanced by small amounts of thrombin.
Nitracrine
Acridine antineoplastic agent used in mammary and ovarian tumors. It inhibits RNA synthesis.
Factor V Deficiency
A deficiency of blood coagulation factor V (known as proaccelerin or accelerator globulin or labile factor) leading to a rare hemorrhagic tendency known as Owren's disease or parahemophilia. It varies greatly in severity. Factor V deficiency is an autosomal recessive trait. (Dorland, 27th ed)

Evidence suggesting the regulation of a coagulation factor levels in rabbits by a transferable plasma agent. (1/1307)

New Zealand white rabbits were given 30 ml of goat serum intravenously. This procedure resulted in an immediate decrease in platelet count, fibrinogen, and levels of coagulation factors II, V, VII, and X, due to consumption coagulopathy. These factors returned toward baseline levels approximately 12 hr after the injection. Plasma from rabbits who had received goat serum 48 hr previously (donor rabbits) was injected into recipient rabbits. This procedure resulted in a slight rise in the level of coagulation factor II (range, 20%-30%) and a significant rise in factors V (35%-75%), VII (35%-235%), and X (35%-75%) in the recipients. When plasma from control donor rabbits who had not received goat serum was injected into recipients, there was no change in these coagulation factors. It is postulated that the reduction in coagulation factor levels in donor rabbits induces a "coagulopoietin" for each factor or one "coagulopoietin" for all factors which stimulates increased synthesis and/or release of these factors in recipient rabbits.  (+info)

Prospective evaluation of the thrombotic risk in children with acute lymphoblastic leukemia carrying the MTHFR TT 677 genotype, the prothrombin G20210A variant, and further prothrombotic risk factors. (2/1307)

The reported incidence of thromboembolism in children with acute lymphoblastic leukemia (ALL) treated with L-asparaginase, vincristine, and prednisone varies from 2.4% to 11.5%. The present study was designed to prospectively evaluate the role of the TT677 methylenetetrahydrofolate reductase (MTHFR) genotype, the prothrombin G20210A mutation, the factor V G1691A mutation, deficiencies of protein C, protein S, antithrombin, and increased lipoprotein (a) concentrations in leukemic children treated according to the ALL-Berlin-Frankfurt-Muenster (BFM) 90/95 study protocols with respect to the onset of vascular events. Three hundred and one consecutive leukemic children were enrolled in this study. Fifty-five of these 301 subjects investigated had one established single prothrombotic risk factor: 20 children showed the TT677 MTHFR genotype; 5 showed the heterozygous prothrombin G20210A variant; 11 were carriers of the factor V G1691A mutation (heterozygous, n = 10; homozygous, n = 1); 4 showed familial protein C, 4 protein S, and 2 antithrombin type I deficiency; 9 patients were suffering from familially increased lipoprotein (a) [Lp(a)] concentrations (>30 mg/dL). In addition, combined prothrombotic defects were found in a further 10 patients: the FV mutation was combined with the prothrombin G20210A variant (n = 1), increased Lp(a) (n = 3), protein C deficiency (n = 1), and homozygosity for the C677T MTHFR gene mutation (n = 1). Lp(a) was combined with protein C deficiency (n = 2) and the MTHFR TT 677 genotype (n = 2). Two hundred eighty-nine of the 301 patients were available for thrombosis-free survival analysis. In 32 (11%) of these 289 patients venous thromboembolism occurred. The overall thrombosis-free survival in patients with at least one prothrombotic defect was significantly reduced compared with patients without a prothrombotic defect within the hemostatic system (P <.0001). In addition, a clear-cut positive correlation (P <.0001) was found between thrombosis and the use of central lines. However, because the prothrombotic defects diagnosed in the total childhood population studied were all found within the prevalences reported for healthy Caucasian individuals, the interaction between prothrombotic risk factors, ALL treatment, and further environmental factors is likely to cause thrombotic manifestations.  (+info)

G20210A mutation in prothrombin gene and risk of myocardial infarction, stroke, and venous thrombosis in a large cohort of US men. (3/1307)

BACKGROUND: A single base pair mutation in the prothrombin gene has recently been identified that is associated with increased prothrombin levels. Whether this mutation increases the risks of arterial and venous thrombosis among healthy individuals is controversial. METHODS AND RESULTS: In a prospective cohort of 14 916 men, we determined the prevalence of the G20210A prothrombin gene variant in 833 men who subsequently developed myocardial infarction, stroke, or venous thrombosis (cases) and in 1774 age- and smoking status-matched men who remained free of thrombosis during a 10-year follow-up (control subjects). Gene sequencing was used to confirm mutation status in a subgroup of participants. Overall, carrier rates for the G20210A mutation were similar among case and control subjects; the relative risk of developing any thrombotic event in association with the 20210A allele was 1.05 (95% CI, 0.7 to 1.6; P=0.8). We observed no evidence of association between mutation and myocardial infarction (RR=0.8, P=0.4) or stroke (RR=1.1, P=0.8). For venous thrombosis, a modest nonsignificant increase in risk was observed (RR=1.7, P=0.08) that was smaller in magnitude than that associated with factor V Leiden (RR=3.0, P<0. 001). Nine individuals carried both the prothrombin mutation and factor V Leiden (5 controls and 4 cases). One individual, a control subject, was homozygous for the prothrombin mutation. CONCLUSIONS: In a large cohort of US men, the G20210A prothrombin gene variant was not associated with increased risk of myocardial infarction or stroke. For venous thrombosis, risk estimates associated with the G20210A mutation were smaller in magnitude than risk estimates associated with factor V Leiden.  (+info)

Injury-induced gelatinase and thrombin-like activities in regenerating and nonregenerating nervous systems. (4/1307)

It is now widely accepted that injured nerves, like any other injured tissue, need assistance from their extracellular milieu in order to heal. We compared the postinjury activities of thrombin and gelatinases, two types of proteolytic activities known to be critically involved in tissue healing, in nonregenerative (rat optic nerve) and regenerative (fish optic nerve and rat sciatic nerve) neural tissue. Unlike gelatinases, whose induction pattern was comparable in all three nerves, thrombin-like activity differed clearly between regenerating and nonregenerating nervous systems. Postinjury levels of this latter activity seem to dictate whether it will display beneficial or detrimental effects on the capacity of the tissue for repair. The results of this study further highlight the fact that tissue repair and nerve regeneration are closely linked and that substances that are not unique to the nervous system, but participate in wound healing in general, are also crucial for regeneration or its failure in the nervous system.  (+info)

Single and combined prothrombotic factors in patients with idiopathic venous thromboembolism: prevalence and risk assessment. (5/1307)

The inherited thrombophilias--deficiencies of protein C, protein S, and antithrombin III--and the prothrombotic polymorphisms factor V G1691A and factor II G20210A predispose patients toward venous thromboembolism (VTE). The aim of this study was to determine the prevalence of single and combined prothrombotic factors in patients with idiopathic VTE and to estimate the associated risks. The study group consisted of 162 patients referred for work-up of thrombophilia after documented VTE. The controls were 336 consecutively admitted patients. In all subjects factor V G1691A, factor II G20210A, and methylenetetrahydrofolate reductase (MTHFR) C677T were analyzed by specific polymerase chain reactions and restriction enzymes. Activities of antithrombin III and protein C, free protein S antigen, and lupus anticoagulant were determined in a subset of 109 patients who were not receiving oral anticoagulants. The prevalences of heterozygotes and homozygotes for factor V G1691A and factor II G20210A among patients and controls were 40.1% versus 3.9% and 18.5% versus 5.4%, respectively (P=0.0001). The prevalence of homozygotes for MTHFR C677T in patients was 22.8% and in controls, 14.3% (P=0.025). Heterozygous and homozygous factor V G1691A, factor II G20210A, and homozygous MTHFR C677T were found to be independent risk factors for VTE, with odds ratios of 16.3, 3.6, and 2.1, respectively. Two or more polymorphisms were detected in 27 of 162 patients (16.7%) and in 3 of 336 controls (0.9%). Logistic regression analysis disclosed odds ratios of 58.6 (confidence interval [CI], 22.1 to 155.2) for joint occurrence of factor V and factor II polymorphisms, of 35.0 (CI, 14.5 to 84.7) for factor V and MTHFR polymorphisms, and of 7.7 (CI, 3.0 to 19.6) for factor II and MTHFR polymorphisms. Among 109 patients in whom a complete thrombophilic work-up was performed, 74% had at least 1 underlying defect. These data indicate that in most patients referred for evaluation of thrombophilia due to idiopathic VTE, 1 or more underlying genetic predispositions were discernible. The presence of >1 of the prothrombotic polymorphisms was associated with a substantial risk of VTE.  (+info)

Interaction between the G20210A mutation of the prothrombin gene and oral contraceptive use in deep vein thrombosis. (6/1307)

Single-point mutations in the gene coding for prothrombin (factor II:A20210) or factor V (factor V:A1691) are associated with an increased risk of venous thromboembolism. The use of oral contraceptives is also a strong and independent risk factor for the disease, and the interaction between factor V:A1691 and oral contraceptives greatly increases the risk. No information is available about the interaction between oral contraceptives and mutant prothrombin. We investigated 148 women with a first, objectively confirmed episode of deep vein thrombosis and 277 healthy women as controls. Fourteen patients (9.4%) were carriers of factor II:A20210, 24 (16.2%) of factor V:A1691, and 4 (2.7%) of both defects. Among controls, the prevalence was 2.5% for either factor II:A20210 or factor V:A1691, and there was no carrier of both the mutations. The relative risk of thrombosis was 6-fold for factor II:A20210 and 9-fold for factor V:A1691. The most prevalent circumstantial risk factor in patients and the only one observed in controls was oral contraceptive use, which per se conferred a 6-fold increased risk of thrombosis. The risk increased to 16.3 and 20.0 when women with factor II:A20210 or factor V:A1691 who used oral contraceptives were compared with noncarriers and nonusers. These figures indicate a multiplicative interaction between the genetic risk factors and oral contraceptives. No difference in the type of oral contraceptives was observed between patients and controls, those of third generation being the most frequently used (73% and 80%). We conclude that carriers of the prothrombin mutation who use oral contraceptives have a markedly increased risk of deep vein thrombosis, much higher than the risk conferred by either factor alone.  (+info)

Synergistic effects of prothrombotic polymorphisms and atherogenic factors on the risk of myocardial infarction in young males. (7/1307)

Several recent studies evaluated a possible effect of the prothrombotic polymorphisms such as 5,10 methylenetetrahydrofolate reductase (MTHFR) nt 677C --> T, factor V (F V) nt 1691G --> A (F V Leiden), and factor II (F II) nt 20210 G --> A on the risk of myocardial infarction. In the present study, we analyzed the effect of these prothrombotic polymorphisms, as well as apolipoprotein (Apo) E4, smoking, hypertension, diabetes mellitus, and hypercholesterolemia, on the risk of myocardial infarction in young males. We conducted a case-control study of 112 young males with first acute myocardial infarction (AMI) before the age of 52 and 187 healthy controls of similar age. The prevalences of heterozygotes for F V G1691A and F II G20210A were not significantly different between cases and controls (6.3% v 6.4% and 5.9% v 3.4% among cases and controls, respectively). In contrast, the prevalence of MTHFR 677T homozygosity and the allele frequency of Apo E4 were significantly higher among patients (24.1% v 10.7% and 9.4% v 5.3% among cases and controls, respectively). Concomitant presence of hypertension, hypercholesterolemia, or diabetes and one or more of the four examined polymorphisms increased the risk by almost ninefold (odds ratio [OR] = 8.66; 95% confidence interval [CI], 3.49 to 21.5) and concomitant smoking by almost 18-fold (OR = 17.6; 95% CI, 6.30 to 48.9). When all atherogenic risk factors were analyzed simultaneously by a logistic model, the combination of prothrombotic and Apo E4 polymorphisms with current smoking increased the risk 25-fold (OR = 24.7; 95% CI, 7.17 to 84.9). The presented data suggest a synergistic effect between atherogenic and thrombogenic risk factors in the pathogenesis of AMI, as was recently found in a similar cohort of women.  (+info)

Thrombophilia as a multigenic disease. (8/1307)

BACKGROUND AND OBJECTIVE: Venous thrombosis is a common disease annually affecting 1 in 1000 individuals. The multifactorial nature of the disease is illustrated by the frequent identification of one or more predisposing genetic and/or environmental risk factors in thrombosis patients. Most of the genetic defects known today affect the function of the natural anticoagulant pathways and in particular the protein C system. This presentation focuses on the importance of the genetic factors in the pathogenesis of inherited thrombophilia with particular emphasis on those defects which affect the protein C system. INFORMATION SOURCES: Published results in articles covered by the Medline database have been integrated with our original studies in the field of thrombophilia. STATE OF THE ART AND PERSPECTIVES: The risk of venous thrombosis is increased when the hemostatic balance between pro- and anti-coagulant forces is shifted in favor of coagulation. When this is caused by an inherited defect, the resulting hypercoagulable state is a lifelong risk factor for thrombosis. Resistance to activated protein C (APC resistance) is the most common inherited hypercoagulable state found to be associated with venous thrombosis. It is caused by a single point mutation in the factor V (FV) gene, which predicts the substitution of Arg506 with a Gln. Arg506 is one of three APC-cleavage sites and the mutation results in the loss of this APC-cleavage site. The mutation is only found in Caucasians but the prevalence of the mutant FV allele (FV:Q506) varies between countries. It is found to be highly prevalent (up to 15%) in Scandinavian populations, in areas with high incidence of thrombosis. FV:Q506 is associated with a 5-10-fold increased risk of thrombosis and is found in 20-60% of Caucasian patients with thrombosis. The second most common inherited risk factor for thrombosis is a point mutation (G20210A) in the 3' untranslated region of the prothrombin gene. This mutation is present in approximately 2% of healthy individuals and in 6-7% of thrombosis patients, suggesting it to be a mild risk factor of thrombosis. Other less common genetic risk factors for thrombosis are the deficiencies of natural anticoagulant proteins such as antithrombin, protein C or protein S. Such defects are present in less than 1% of healthy individuals and together they account for 5-10% of genetic defects found in patients with venous thrombosis. Owing to the high prevalence of inherited APC resistance (FV:Q506) and of the G20210A mutation in the prothrombin gene, combinations of genetic defects are relatively common in the general population. As each genetic defect is an independent risk factor for thrombosis, individuals with multiple defects have a highly increased risk of thrombosis. As a consequence, multiple defects are often found in patients with thrombosis.  (+info)

Staphylocoagulase-binding region in human prothrombin<...
TY - JOUR. T1 - Staphylocoagulase-binding region in human prothrombin. AU - Kawabata, Shun-Ichiro. AU - Morita, Takashi. AU - Iwanaga, Sadaaki. AU - Igarashi, Hideo. PY - 1985/1/1. Y1 - 1985/1/1. N2 - A staphylocoagulase-binding region in human prothrombin was studied by utilizing several fragments prepared from prothrombin by limited proteolysis. Bovine prothrombin, prethrombin 1, prethrombin 2, and human diisopropylphosphorylated α-thrombin strongly inhibited formation of the complex (staphylothrombin) between human prothrombin and staphylocoagulase, but bovine prothrombin fragment 1 and fragment 2 had no effect on the complex formation, indicating that the binding region of human prothrombin for staphylocoagulase is located in the prethrombin 2 molecule. To identify further the staphylocoagulase-binding region, human α-thrombin was cleaved into the NH2-terminal large fragment (Mr = 26, 000) and the COOH-terminal fragment (Mr = 16,000) by porcine pancreatic elastase. Of these fragments, ...
https://kyushu-u.pure.elsevier.com/en/publications/staphylocoagulase-binding-region-in-human-prothrombin
Prothrombin Analysis | Prothrombin (Factor II) G20210A Mutation | University HospitalsProthrombin Analysis | Prothrombin (Factor II) G20210A Mutation | University Hospitals
Prothrombin (Factor II) G20210A mutation is associated with elevated prothrombin levels. Individuals heterozygous for this mutation have an estimated 3-8 fold increased risk for venous thrombosis. The G20210A mutation has an overall prevalence of up to 3% in the Caucasian population, but it is rarely seen in other ethnic groups.. Analysis for the prothrombin G20210A mutation is offered as a specific DNA test, or as part of a thrombophilia panel (see Thrombosis panel) which also includes the factor V Leiden analysis. 8-14% of G20210A heterozygotes have other inherited thrombophilic disorders. Individuals with multiple thrombophilic mutations develop venous thromboembolism at a younger age and are at higher risk for recurrent thrombosis than those with a single defect.. ...
https://www.uhhospitals.org/for-clinicians/specialties/genetics/laboratory-tests-offered/prothrombin-analysis
Introduction prothrombin levels and increased risk of thrombosis. (1) - Database projects for students
Introduction Thrombophilia is clinical tendency to develop thrombosis. Amutation in the gene encoding coagulation factor V is a common geneticpredisposition to venous thrombosis. A second common genetic risk isprothrombin gene mutation, the G20210A variation associated with elevatedplasma prothrombin levels and increased risk of thrombosis. (1) Furthermore,Protein S deficiency is a rare condition that can lead to DVT.. (2) We presentto you a case of multifactorial hemophilia with a heterozygous prothrombin genemutation, factor V Leiden deficiency, and protein s deficiency. Clinical case:A 48 Years old Saudi man knowing Case of DM, Dyslipidemiawas admitted to our hospital because of left leg swelling after long travel for10 hours. He had the previous history of DVT for 4 years. It was investigatedand he had factor v laden deficiency that confirmed by PCR Assay and he startedwarfarin but he stopped it after 10 months. he had no previous surgery norfamily history or active cancer. On examination, ...
https://walktocurecancer.org/introduction-prothrombin-levels-and-increased-risk-of-thrombosis-1/
Immunomagnetic reduction assay on des-gamma-carboxy prothrombin for screening of hepatocellular carcinoma<...Immunomagnetic reduction assay on des-gamma-carboxy prothrombin for screening of hepatocellular carcinoma<...
TY - JOUR. T1 - Immunomagnetic reduction assay on des-gamma-carboxy prothrombin for screening of hepatocellular carcinoma. AU - Chieh, Jen Jie. AU - Huang, K. W.. AU - Chuang, C. P.. AU - Wei, W. C.. AU - Dong, J. J.. AU - Lee, Y. Y.. N1 - Funding Information: This work was supported by the National Science Council of Taiwan under Grant NSC100-2221-E003-013, Grant NSC 103-2923-M-003-002-, Grant NSC 103-2112-M-003-010, the Ministry of Health and Welfare under Grant MOHW103-TDU-N-211-133002, Aim for the Top University Plan of the National Taiwan Normal University, and the Ministry of Education, Taiwan, under Grant 103J1A27.. PY - 2016/8. Y1 - 2016/8. N2 - The accredited biomarker alpha-fetoprotein (AFP) offers limited sensitivity and specificity in the early detection of hepatocellular carcinoma (HCC). To improve the screening performance, des-gamma-carboxy prothrombin (DCP) has been identified as another promising biomarker of HCC, combined with AFP biomarkers. The results of the commercial ...
https://scholar.lib.ntnu.edu.tw/en/publications/immunomagnetic-reduction-assay-on-des-gamma-carboxy-prothrombin-f
Repositorio da Producao Cientifica e Intelectual da Unicamp: Prevalence of the prothrombin gene variant (nt20210A) in venous...Repositorio da Producao Cientifica e Intelectual da Unicamp: Prevalence of the prothrombin gene variant (nt20210A) in venous...
The prothrombin gene variant resulting form a G--,A transition at position 20210 has been described as a common genetic risk factor for venous thrombosis. However, the risk for developing arterial disease is unknown. In this investigation, we studied 116 patients with venous thrombosis and 71 with arterial disease, all of whom were compared with 295 controls. Additionally, we also investigated the distribution of the prothrombin alleles among African descendents and Amazonian Indians from Brazil. The prevalence of 0.7% for 20210A allele in the control group increased to 4.3% (P = 0.021) among patients with venous thrombosis. There was also a high prevalence of the mutated allele in a selected arterial disease group (5.7%) without hyperlipoproteinemia, hypertension, and diabetes mellitus when compared to the controls (P = 0.013). Heterozygotes for the allele 20210A were common among individuals of African descent (2%) and rare among Indians. These data support the hypothesis that the prothrombin ...
http://repositorio.unicamp.br/jspui/handle/REPOSIP/70242
Abnormal prothrombin (DES-y-Carboxy Prothrombin) in hepatocellular carcinoma - D-Scholarship@PittAbnormal prothrombin (DES-y-Carboxy Prothrombin) in hepatocellular carcinoma - [email protected]
Nakao, A and Virji, A and Iwaki, Y and Carr, B and Iwatsuki, S and Starzl, E (1991) Abnormal prothrombin (DES-y-Carboxy Prothrombin) in hepatocellular carcinoma. Hepato-Gastroenterology, 38. 450 - 453. ISSN 0172-6390 ...
http://d-scholarship.pitt.edu/4714/
Does low prothrombin level mean progressing liver disease? - Hepatitis C - MedHelpDoes low prothrombin level mean progressing liver disease? - Hepatitis C - MedHelp
My recent CBC showed prothrombin level (PT) is low (1 in a reference range of 2-3). Previous test in 2004 showed normal level. I understand that this means blood clots too slowly and is sometimes cau...
https://www.medhelp.org/posts/Hepatitis-C/Does-low-prothrombin-level-mean-progressing-liver-disease/show/289499
Prothrombin G20210A - WikipediaProthrombin G20210A - Wikipedia
The variant causes elevated plasma prothrombin levels (hyperprothrombinemia),[4] possibly due to increased pre-mRNA stability.[5] Prothrombin is the precursor to thrombin, which plays a key role in causing blood to clot (blood coagulation). G20210A can thus contribute to a state of hypercoagulability, but not particularly with arterial thrombosis.[4] A 2006 meta-analysis showed only a 1.3-fold increased risk for coronary disease.[6] Deficiencies in the anticoagulants Protein C and Protein S further increase the risk five- to tenfold.[2] Behind non-O blood type[7] and factor V Leiden, prothrombin G20210A is one of the most common genetic risk factors for VTE.[4] Increased production of prothrombin heightens the risk of blood clotting. Moreover, individuals who carry the mutation can pass it on to their offspring.[8] The mutation increases the risk of developing deep vein thrombosis (DVT),[9] which can damage veins throughout the body, causing pain and swelling and sometimes leading to ...
https://en.wikipedia.org/wiki/Prothrombin_G20210A
United States Human Prothrombin Complex Market Report 2016United States Human Prothrombin Complex Market Report 2016
Sales, means the sales volume of Human Prothrombin Complex Revenue, means the sales value of Human Prothrombin Complex This report studies sales (consumption) of Human Prothrombin Complex in United States market, focuses on the top players, with sales, price, revenue and market share for each player, covering Baxter CSL Bayer Grifols Octapharma Shanghai RAAS Hualan Bio
https://www.researchmoz.us/united-states-human-prothrombin-complex-market-report-2016-report.html
prothrombin gene mutation -Doctors Lounge(TM)prothrombin gene mutation -Doctors Lounge(TM)
In March 2006 I began experiencing pain in my right jaw and neck. An ultrasound of my thyroid showed a mild enlargement of my thyroid gland and thrombosis of the right internal jugular. A CT was ordered which showed bilateral segmental pulmonary emboli. A work up done to rule out cancer was negative however blood work showed a prothrombin gene mutation. At the time I was taking Yasmin. I was placed on Coumadin and told I should stay on this forever. I am worried that the risk of a bleed may now outweigh the need for anticoagulation since the thyroiditis is controlled and I am off oral contraceptives. Would it be wise to stop the Coumadin or is long-term use still recommended? Thank you ...
https://www.doctorslounge.com/hematology/forums/backup/topic-38465.html
Prothrombin g20210a mutation | Article about Prothrombin g20210a mutation by The Free DictionaryProthrombin g20210a mutation | Article about Prothrombin g20210a mutation by The Free Dictionary
Looking for Prothrombin g20210a mutation? Find out information about Prothrombin g20210a mutation. see blood clotting blood clotting, process by which the blood coagulates to form solid masses, or clots. In minor injuries, small oval bodies called... Explanation of Prothrombin g20210a mutation
http://encyclopedia2.thefreedictionary.com/Prothrombin+g20210a+mutation
G20210A Prothrombin Gene Polymorphism and Prothrombin Activity in Subjects With or Without Angiographically Documented Coronary...G20210A Prothrombin Gene Polymorphism and Prothrombin Activity in Subjects With or Without Angiographically Documented Coronary...
Although the prevalence of G20210A prothrombin gene mutation was higher among our CAD patients than among control subjects, this difference did not reach statistical significance. Similarly, we found no difference in distribution of genotypes between CAD patients with or without previous MI. These results provide evidence against a major role for G20210A mutation as a risk factor for either CAD or MI, at least in the present study conditions.. Previous data are controversial. Some authors have reported observations consistent with ours20 21 22 23 24 25 26 27 ; in particular, the only prospective study published so far found no association between the 20210A allele and the risk of MI.18 However, caution in the interpretation of the results of that study has been suggested,11 mainly because of the procedures used for end-point validation, which were considered inappropriate for ensuring the quality of controls. Furthermore, because of the high heterogeneity of the population observed, these ...
http://circ.ahajournals.org/content/103/20/2436
Venom prothrombin activator omicarin-C catalytic subunit precursor - Oxyuranus microlepidotus (Inland taipan)Venom prothrombin activator omicarin-C catalytic subunit precursor - Oxyuranus microlepidotus (Inland taipan)
Snake prothrombin activator that attacks the hemostatic system of prey. This catalytic subunit is functionally similar to blood coagulation factor Xa. It requires a non-catalytic subunit present in the venom, which is similar to coagulation factor Va, to be fully active (By similarity).
http://www.uniprot.org/uniprot/Q58L95
Factor II (Prothrombin) MutationFactor II (Prothrombin) Mutation
Please click on the Lab Form Link in the Forms Section to print and complete the Genetic Test Requisition Form. Submission of completed Genetic Test Requisition Form is required, and submission of informed consent form is recommended (but not required).. This test is a targeted mutation analysis that detects presence of the 20210G,A (also known as G20210A or c.*97G,A) pathogenic mutation in the Factor 2 (F2) gene and can determine whether this mutation is present in heterozygous or homozygous state in a patient. The F2 gene encodes coagulation Factor II, also known as prothrombin, protein. The presence of 20210G,A mutation in the F2 gene increases the patients risk for prothrombin-related thrombophilia, which is characterized by venous thromboembolism (VTE) that manifest most commonly in adults and is associated with elevated prothrombin levels.. ...
https://www.nationwidechildrens.org/specialties/laboratory-services/lab-test-directory/factor-ii-prothrombin-mutation
Gene structures of Trocarin D and coagulation factor X, two functionally diverse prothrombin activators from Australian rough...Gene structures of Trocarin D and coagulation factor X, two functionally diverse prothrombin activators from Australian rough...
Activation of prothrombin to thrombin is the key reaction in blood coagulation cascade. We have recently shown that Australian rough scaled snake, Tropidechis carinatus, possesses two parallel prothrombin activator systems. Trocarin D, a venom prothrombin activator produced in the venom gland, plays an offensive role as a toxin, whereas factor X is produced in the liver and plays a role in the hemostatic mechanism. These two proteins are structurally similar and have identical domain architecture. Because of the differences in their physiological roles, and tissue-specific expression, we determined the gene structure of these closely related proteins. Both the genes have eight exons similar to all mammalian factor X genes. All the exon-intron boundaries of these two genes are at the same position and the splice junctions are almost identical. Partial sequencing of the introns shows that they share a very high degree of sequence identity indicating that the gene duplication is a recent event. ...
https://scholarbank.nus.edu.sg/handle/10635/102212
Decreased prothrombin conversion and reduced thrombin inactivation explain rebalanced thrombin generation in liver cirrhosis<...
TY - JOUR. T1 - Decreased prothrombin conversion and reduced thrombin inactivation explain rebalanced thrombin generation in liver cirrhosis. AU - Kremers, Romy M. W.. AU - Kleinegris, Marie-Claire. AU - Ninivaggi, Marisa. AU - de Laat, Bas. AU - ten Cate, Hugo. AU - Koek, Ger H.. AU - Wagenvoord, Rob J.. AU - Hemker, H. Coenraad. PY - 2017/5/4. Y1 - 2017/5/4. KW - MOLECULAR-WEIGHT HEPARIN. KW - CONVENTIONAL COAGULATION TESTS. KW - HEPATITIS-C PATIENTS. KW - PROTEIN-C. KW - VENOUS THROMBOEMBOLISM. KW - CLINICAL CONSEQUENCES. KW - PLASMA. KW - DISEASE. KW - COAGULOPATHY. KW - INHIBITION. U2 - 10.1371/journal.pone.0177020. DO - 10.1371/journal.pone.0177020. M3 - Article. C2 - 28472132. VL - 12. JO - PLOS ONE. JF - PLOS ONE. SN - 1932-6203. IS - 5. M1 - 0177020. ER - ...
https://cris.maastrichtuniversity.nl/en/publications/decreased-prothrombin-conversion-and-reduced-thrombin-inactivatio
Soluble phospholipids enhance factor Xa-catalyzed prothrombin activation in solutionSoluble phospholipids enhance factor Xa-catalyzed prothrombin activation in solution
Koppaka, V.; Wang, J.; Banerjee, M.; Lentz, B.R., 1996: Soluble phospholipids enhance factor Xa-catalyzed prothrombin activation in solution
https://eurekamag.com/research/009/432/009432149.php
A Common Prothrombin Variant (20210 G to A) Increases the Risk of Myocardial Infarction in Young Women | Survey Research Center
Using specimens from a population-based case control study among women ages 18 to 44 years in western Washington, we assessed the relationship between carriership of a genetic clotting factor II variant (20210 G→A) and myocardial infarction (MI). The factor II variant was previously shown to be present in 1% to 2% of the population, to increase the levels of factor II, and to be associated with venous thrombotic disease. Personal interviews and blood samples were obtained from 79 women with a first myocardial infarction and 381 control women identified through random-digit telephone dialing. Polymerase chain reaction (PCR) method was used to determine the factor II genotypes. The factor II 20210 G to A transition was present more often in women with MI (5.1%) than among control women (1.6%). The age-adjusted odds ratio for MI was 4.0 (95% confidence interval 1.1 to 15.1). The relative risk was high when another major cardiovascular risk factor was also present, such as smoking (odds ratio ...
https://www.src.isr.umich.edu/publications/a-common-prothrombin-variant-20210-g-to-a-increases-the-risk-of-myocardial-infarction-in-young-women/
NARScissistic ( The Journey of A Nurse)
The formation of a blood clot depends on a number of proteins found within plasma called clotting factors. Normally the clotting factors are inactive and do not cause clotting. Following injury however, the clotting factors are activated to produce a clot. This is a complex process involving chemical reactions, but it can be summarized in 3 main stages; the chemical reactions can be stated in two ways: just as with platelets, the contact of inactive clotting factors with exposed connective tissue can result in their activation. Chemicals released from injured tissues can also cause activation of clotting factors. After the initial clotting factors are activated, they in turn activate other clotting factors. A series of reactions results in which each clotting factor activates the next clotting factor in the series until the clotting factor prothrombin activator is formed. Prothrombin activator acts on an inactive clotting factor called prothrombin. Prothrombin is converted to its active form ...
http://greenerpasture09.blogspot.com
Prothrombin (474-477) [Mus musculus]|Role in coagulation cascadeProthrombin (474-477) [Mus musculus]|Role in coagulation cascade
|p||strong|Prothrombin|/strong| (coagulation factor II) (H2N-Tyr-Ile-His-Pro-OH) is produced in the liver and is post-translationally modified in a vitamin K-dependent reaction that converts ten glutamic acids on prothrombin into gamma-carboxyglutamic aci
http://www.apexbt.com/coagulation-factor-ii-peptide-prothrombin-474-477-mus-musculus.html
Prothrombin Complex ConcentrateProthrombin Complex Concentrate
This page includes the following topics and synonyms: Prothrombin Complex Concentrate, Prothrombin Drug Combination, PCC, Beriplex, Octaplex, Kcentra, Cofact.
http://fpnotebook.com/HemeOnc/Pharm/PrthrmbnCmplxCncntrt.htm
Evaluation of a New Homogeneous Immunoassay for Quantification of Prothrombin Fragment 1+2 (F1+2) - Siemens Healthineers GlobalEvaluation of a New Homogeneous Immunoassay for Quantification of Prothrombin Fragment 1+2 (F1+2) - Siemens Healthineers Global
Prothrombin fragment F1+2 aids in the risk assessment of thrombosis and efficacy of anticoagulant treatment monitoring. Now for the first time, LOCI® technology* is being used to deliver an improved testing method for the measurement of F1+2.
https://www.healthcare.siemens.com/hemostasis/webinars/evaluation-new-homogeneous-immunoassay.html
Natural Human Prothrombin protein (ab62502) | AbcamNatural Human Prothrombin protein (ab62502) | Abcam
Buy our Natural Human Prothrombin protein. Ab62502 is a protein fragment produced in Nativesyntheticaly and has been validated in FuncS, SDS-PAGE. Abcam…
http://www.abcam.com/natural-human-prothrombin-protein-ab62502.html
Prothrombin
Literature References: Mol wt 69,000-74,000. Coagulation proenzyme present in highest concentration in blood. Prothrombin is one of the vitamin-K dependent blood coagulation factors. It is converted to thrombin by the action of factor Xa, factor V and phospholipid in the presence of Ca2+ ions. Accounts for , 0.2% of total plasma protein. Prepn of human and bovine prothrombin: Goldstein et al., J. Biol. Chem. 234, 2857 (1959); Lanchantin et al., ibid. 238, 238 (1963). Chemistry of activation: Magnussen, Biochem. J. 115, 2P (1969). Synthesized normally by liver parenchymal cells in a cyclic asynchronous manner. Dicoumarol derivatives halt the synthesis, while vitamin K1 stimulates synchronized activity of all the liver parenchymal cells: Barnhart, Anderson, Biochem. Pharmacol. 9, 23 (1962). The glycoprotein structure probably consists of a single polypeptide chain containing between 8 and 10% carbohydrate: Magnussen, Thromb. Diath. Haemorrh. suppl. 54, 31 (1973). Reviews: W. H. Seegers, ...
https://www.drugfuture.com/chemdata/Prothrombin.html
MIN - what is Azionyl used for, general information, pharmacology, Azionyl for patients, Azionyl interactions, Azionyl...MIN - what is Azionyl used for, general information, pharmacology, Azionyl for patients, Azionyl interactions, Azionyl...
Caution should be exercised when anticoagulants are given in conjunction with Atromid-S. Usually, the dosage of the anticoagulant should be reduced by one-half (depending on the individual case) to maintain the prothrombin time at the desired level to prevent bleeding complications. Frequent prothrombin determinations are advisable until it has been determined definitely that the prothrombin level has been stabilized.. Atromid-S may displace acidic drugs such as phenytoin or tolbutamide from their binding sites. Caution should be exercised when treating patients with either of these drugs or other highly protein-bound drugs and Atromid-S. The hypoglycemic effect of tolbutamide has been reported to increase when Atromid-S is given concurrently.. Fulminant rhabdomyolysis has been seen as early as three weeks after initiation of combined therapy with another fibrate and lovastatin but may be seen after several months. For these reasons, it is felt that, in most subjects who have had an ...
http://www.minclinic.ru/drugs/drugs_eng/A/Azionyl.html
MIN - what is Amotril S used for, general information, pharmacology, Amotril S for patients, Amotril S interactions, Amotril S...MIN - what is Amotril S used for, general information, pharmacology, Amotril S for patients, Amotril S interactions, Amotril S...
Caution should be exercised when anticoagulants are given in conjunction with Atromid-S. Usually, the dosage of the anticoagulant should be reduced by one-half (depending on the individual case) to maintain the prothrombin time at the desired level to prevent bleeding complications. Frequent prothrombin determinations are advisable until it has been determined definitely that the prothrombin level has been stabilized.. Atromid-S may displace acidic drugs such as phenytoin or tolbutamide from their binding sites. Caution should be exercised when treating patients with either of these drugs or other highly protein-bound drugs and Atromid-S. The hypoglycemic effect of tolbutamide has been reported to increase when Atromid-S is given concurrently.. Fulminant rhabdomyolysis has been seen as early as three weeks after initiation of combined therapy with another fibrate and lovastatin but may be seen after several months. For these reasons, it is felt that, in most subjects who have had an ...
http://www.minclinic.ru/drugs/drugs_eng/A/Amotril%20S.html
Global Prothrombin Complex Market 2020 by Manufacturers, Regions, Type and Application, Forecast to 2025 : ReportsnReports
[106 Pages Report] Check for Discount on Global Prothrombin Complex Market 2020 by Manufacturers, Regions, Type and Application, Forecast to 2025 report by Global Info Research. Market Overview The global Prothrombin Complex market size is expected...
https://www.reportsnreports.com/reports/2857624-global-prothrombin-complex-market-2020-by-manufacturers-regions-type-and-application-forecast-to-2025.html
Prothrombin Ab IgA ELISA KitProthrombin Ab IgA ELISA Kit
Human prothrombin IgA ELISA kit is an in-vitro quantitative method for detecting levels of IgA autoantibodies to prothrombin in human plasma and serum.
http://www.elisakits.co.uk/prothrombin-ab-iga-elisa-kit/
Abstract 12300: Time-Dependent Changes of Local Vascular Response and Angiographic Peri-Stent Contrast Staining up to Five...Abstract 12300: Time-Dependent Changes of Local Vascular Response and Angiographic Peri-Stent Contrast Staining up to Five...
Purpose: We have previously reported local persistent hypercoagulability six months after sirolimus-eluting stent (SES) implantation by measuring plasma prothrombin fragment F1+2 (frF1+2) levels. The aims of this study are to examine the relationship between time-dependent changes of local vascular response and angiographic peri-stent contrast staining (PSS) following zotarolimus-eluting stent (ZES), SES, and bare-metal stent (BMS) implantation.. Methods: Eighty-five patients treated five years earlier with coronary stenting, with no evidence of restenosis, were studied [ZES: 20, SES: 35, and BMS: 30]. We measured the levels of frF1+2 and pentraxin3 (PTX3) from the coronary sinus (CS) and sinus of Valsalva (V) 6 months (6M) and 5 years (5Y) after stent implantation. The transcardiac gradient (Δ) was defined as the CS levels minus V levels. The occurrence rate of PSS was evaluated and compared among ZES, SES, and BMS groups.. Results: The ΔfrF1+2 (6M) was smaller in the ZES or BMS group than in ...
http://circ.ahajournals.org/content/128/Suppl_22/A12300
Process and reagent for the determination of prothrombin - Boehringer Mannheim GmbHProcess and reagent for the determination of prothrombin - Boehringer Mannheim GmbH
A novel process for the determination of prothrombin in biological material, by conversion of prothrombin into thrombin, enzymatic fission of a thrombin substrate and measurement of a fission product,
http://www.freepatentsonline.com/4334018.html
Tips to overcome Vitamin DeficiencyTips to overcome Vitamin Deficiency
The deficiency of vitamin K in the body can trigger the problems of coagulation, which is very uncommon in people. Moreover, the level of prothrombin below the 20% is another bad symptom; it aggravates the chances of spontaneous gingival hemorrhages that can disturb the dental formation in a negative way. Another cause is gingival is bleeding, especially after the brushing of the teeth or when prothrombin level falls down to the 35%. This affects the normal development of teeth and gums, which are considered normal for the oral hygiene. Furthermore, the deficiency of vitamin K can cause serious gums diseases by affecting the dental health. Hence, the role of a dentist is crucial in guiding people to avoid this deficiency in them ...
http://yinghui-doraemon.blogspot.com/2017/04/tips-to-overcome-vitamin-deficiency.html
Aperçu des produits pour Prothrombin kit ELISAAperçu des produits pour Prothrombin kit ELISA
Commander Prothrombin kit ELISA pour beaucoup de réactivité. Poulet, Boeuf (Vache), Chien et plus. Comparez Prothrombin kit ELISA et trouvez le bon produit chez anticorps-enligne.fr.
https://www.anticorps-enligne.fr/systeme-du-complement-pathway-11/prothrombin-elisa-kit-329/
CP-072 Use of human prothrombin complex concentrate in patients at high risk of severe bleeding in a trauma hospital | European...CP-072 Use of human prothrombin complex concentrate in patients at high risk of severe bleeding in a trauma hospital | European...
Results 45 patients were treated with PCC and included in the analysis. Mean patient age was 59.64 years, 42.2% were women and 57.77% men. The average dose was 1604 IU, the global survival after seven days was 73.33% and 35.55% had concomitant treatment with fibrinogen.. 11.11% of the patients had been treated with oral anticoagulants (OAT) prior to the emergency bleeding,. 48.89% had polytraumatic wounds,. 4.44% had thrombocytopenia secondary to hepatopathy,. 0% had haemophilia,. 75.55% had an active haemorrhage,. 68.89% underwent surgery, when the PCC was administered.. Quick time (s) (% // INR):. ...
http://ejhp.bmj.com/content/21/Suppl_1/A29.3
Prothrombin complex human Intravenous Advanced Patient Information - Drugs.comProthrombin complex human Intravenous Advanced Patient Information - Drugs.com
Detailed drug Information for prothrombin complex human Intravenous. Includes common brand names, drug descriptions, warnings, side effects and dosing information.
https://www.drugs.com/cons/prothrombin-complex-human-intravenous.html
Four things about... (a simple approach to anatomy and physiology): ProtectionFour things about... (a simple approach to anatomy and physiology): Protection
ANSWER: Prothrombin activator formed by intrinsic and extrinsic systems, converts prothrombin to thrombin which converts fibrinogen to fibrin which forms a clot with platelets ...
http://fourthingsabout.blogspot.com/2012/01/protection.html
Genesis 17:12 and Prothrombin | Last RowGenesis 17:12 and Prothrombin | Last Row
And every male among you who is eight days old shall be circumcised throughout your generations... Genesis 17:12 Prothrombin is a plasma protein involved in the blood clotting process. Specifically it is the precursor of the enzyme thrombin, which catalyzes the final step of the clotting process ( Vitamin K along with calcium is needed…
https://lastrow.wordpress.com/2007/01/18/genesis-1712-and-prothrombin/
AID 787716 - Open TG-GATES: Regimen: Single; Time: 9 hr; Dose: Low; Route: Gavage | Dataset: Hematology; Assay: PT (Prothrombin...AID 787716 - Open TG-GATES: Regimen: Single; Time: 9 hr; Dose: Low; Route: Gavage | Dataset: Hematology; Assay: PT (Prothrombin...
BioAssay record AID 787716 submitted by ChEMBL: Open TG-GATES: Regimen: Single; Time: 9 hr; Dose: Low; Route: Gavage | Dataset: Hematology; Assay: PT (Prothrombin Time); Study_ID: 517/7.
https://pubchem.ncbi.nlm.nih.gov/bioassay/787716
AID 813331 - Open TG-GATES: Regimen: Single; Time: 6 hr; Dose: Low; Route: Gavage | Dataset: Hematology; Assay: PT (Prothrombin...AID 813331 - Open TG-GATES: Regimen: Single; Time: 6 hr; Dose: Low; Route: Gavage | Dataset: Hematology; Assay: PT (Prothrombin...
BioAssay record AID 813331 submitted by ChEMBL: Open TG-GATES: Regimen: Single; Time: 6 hr; Dose: Low; Route: Gavage | Dataset: Hematology; Assay: PT (Prothrombin Time); Study_ID: 125/6.
https://pubchem.ncbi.nlm.nih.gov/bioassay/813331
Prothrombin - Forum on Hepatitis and HIV Coinfection - TheBody.comProthrombin - Forum on Hepatitis and HIV Coinfection - TheBody.com
Prothrombin time is a measure of blood clotting function. More than likely, the changes from normal to abnormal and back to normal in an otherwise healthy person or someone with only mild liver...
http://www.thebody.com/Forums/AIDS/Hepatitis/Q114733.html
Gentaur Molecular :Molecular Innovations \ Sheep Anti Mouse Prothrombin IgG fraction \ SASMPT-GFGentaur Molecular :Molecular Innovations \ Sheep Anti Mouse Prothrombin IgG fraction \ SASMPT-GF
Gentaur molecular products has all kinds of products like :search , Molecular Innovations \ Sheep Anti Mouse Prothrombin IgG fraction \ SASMPT-GF for more molecular products just contact us
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Gentaur Molecular :Molecular Innovations \ Sheep Anti Mouse Prothrombin antiserum \ SASMPTGentaur Molecular :Molecular Innovations \ Sheep Anti Mouse Prothrombin antiserum \ SASMPT
Gentaur molecular products has all kinds of products like :search , Molecular Innovations \ Sheep Anti Mouse Prothrombin antiserum \ SASMPT for more molecular products just contact us
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Serum prothrombin conversion accelerator | definition of serum prothrombin conversion accelerator by Medical dictionarySerum prothrombin conversion accelerator | definition of serum prothrombin conversion accelerator by Medical dictionary
Looking for online definition of serum prothrombin conversion accelerator in the Medical Dictionary? serum prothrombin conversion accelerator explanation free. What is serum prothrombin conversion accelerator? Meaning of serum prothrombin conversion accelerator medical term. What does serum prothrombin conversion accelerator mean?
https://medical-dictionary.thefreedictionary.com/serum+prothrombin+conversion+accelerator
EPIDEMIOLOGY OF PROTHROMBIN G20210A MUTATION IN THE MEDITERRANEAN REGION | Mediterranean Journal of Hematology and...EPIDEMIOLOGY OF PROTHROMBIN G20210A MUTATION IN THE MEDITERRANEAN REGION | Mediterranean Journal of Hematology and...
There are many genetic and acquired risk factors that are known to cause venous thromboembolic disorders (VTE). One of these is the Prothrombin G20210A mutation, which has been identified in 1996. Prothrombin G20210A mutation causes higher levels of the clotting factor prothrombin in the blood of carriers, which creates a higher tendency towards blood clotting (hypercoagulability), and therefore the carriers become at higher risk of developing VTE. High prevalence of Prothrombin G20210A mutation was reported in Caucasian populations, but the prevalence was almost absent in non-Caucasians. That was most obvious in countries of South Europe and the Mediterranean region. This review article discusses Prothrombin G20210A mutation, how it causes VTE, the origin of the mutation, and its distribution worldwide with special concentration on the Mediterranean area.. ...
http://www.mjhid.org/index.php/mjhid/article/view/2011.054
Prothrombin test | definition of prothrombin test by Medical dictionaryProthrombin test | definition of prothrombin test by Medical dictionary
Looking for online definition of prothrombin test in the Medical Dictionary? prothrombin test explanation free. What is prothrombin test? Meaning of prothrombin test medical term. What does prothrombin test mean?
http://medical-dictionary.thefreedictionary.com/prothrombin+test
Elucidation of procoagulant mechanism and pathophysiological significance of a new prothrombin activating metalloprotease...Elucidation of procoagulant mechanism and pathophysiological significance of a new prothrombin activating metalloprotease...
The procoagulant proteases present in Russells Viper venom (RVV) are responsible for promoting consumption coagulopathy in victims. In this study, a procoagulant metalloprotease (Rusviprotease) possessing prothrombin activating and α-fibrinogenase properties has been purified and characterized from RVV. Rusviprotease is a 26.8 kDa glycoprotein which also exists in other multimeric forms. The peptide mass fingerprinting and secondary structure analyses of Rusviprotease revealed its similarity with snake venom prothrombin activators and metalloproteases. Similar to group A prothrombin activators, Rusviprotease cleaved prothrombin independent of any co-factor requirement generating meizothrombin which is further cleaved to form thrombin. The Km and Vmax values of Rusviprotease towards prothrombin were determined to be 1.73 μM, and 153.5 nM thrombin generated/min/μmoles of Rusviprotease, respectively. The Km and Vmax values of Rusviprotease towards fibrinogen were calculated to be 3.14 μM and ...
https://www.ccamp.res.in/elucidation-procoagulant-mechanism-and-pathophysiological-significance-new-prothrombin-activating
Effects of norethisterone on coagulation and fibrinolysis in Asian women | ScholarBank@NUSEffects of norethisterone on coagulation and fibrinolysis in Asian women | [email protected]
High doses of norethisterone in 70 Asian women treated for endometriosis were found to affect the blood coagulation factors as well as the cellular components of the blood. Fibrinogen level was found to be decreased (p < 0.01). Prothrombin increased significantly (p < 0.001) during the initial three months medication, after which it gradually reverted to baseline values at nine months. Factor V and X were significantly increased throughout the period of therapy (p<0.001) whilst factor VIII showed no change. This is evidence that coagulation factors from the liver are affected by norethisterone whilst that from the vascular endothelium is not. The changes in coagulation factors resulted in a shortened prothrombin time and kaolin cephalin time in the initial period of treatment reflecting the initial increase in prothrombin level. Jaundice occurred in three patients when their prothrombin levels were at their highest for the individual patient. The adjustment and return baseline levels ...
http://scholarbank.nus.edu.sg/handle/10635/107588
Paratope diversity of anti-prothrombin antibodies | Arthritis Research & Therapy | Full TextParatope diversity of anti-prothrombin antibodies | Arthritis Research & Therapy | Full Text
To ascertain the heterogeneity of anti-prothrombin antibodies (aPT), we compared three in-house aPT ELISAs: A) medium binding plates, phosphatidylserine, prothrombin, Tris-buffered saline, calcium; B) high binding plates, prothrombin, Tris-buffered saline; and C) high binding plates, prothrombin, PBS. One serum, exhibiting high positive aPT in all three ELISAs, was selected as the calibrator. Sera from 47 patients (41 with SLE, 4 with pAPS, 2 with arterial thromboses) were tested for IgG and IgM aPT.. The results showed six different patterns: 1) similar results were obtained with A, B and C (similar analytical sensitivity); 2) similar results were obtained with A and B while C showed lower analitycal sensitivity; 3) B and C seemed analytically less sensitive than A; 4) A and B were analytically less sensitive than C; 5) A showed very low analytical sensitivity; 6) A and C showed lower analytical sensitivity than B.. The analysis of all the presented patterns showed noncomparable results of the ...
https://arthritis-research.biomedcentral.com/articles/10.1186/ar636
Supplementary MaterialsS1 Methods: Detailed explanation of prekallikrein production and prothrombin/factor X | EGFR Tyrosine...
Supplementary MaterialsS1 Methods: Detailed explanation of prekallikrein production and prothrombin/factor X lacking plasma assays. Aliquots of 10 L PD184352 ic50 had been taken and generated kallikrein enzymatic activity was determined using the specific chromogenic substrate S2302 (2 mM). The kinetics of p-nitroaniline formation were monitored at 405 nm and curves are representative data from at least three independent experiments. Inset shows the dose-response curve. The amounts of plasma derived kallikrein generated by LOBE was estimated using a calibration curve made with known concentrations of purified kallikrein and thus expressed as pmol of equivalent kallikrein/mL/min.(TIF) pntd.0007197.s004.tif (459K) GUID:?7403B6A2-C7C2-4032-B696-330A483F7AED S4 Fig: LOBE-induced kallikrein generation in factor X and prothrombin deficient PD184352 ic50 plasma. To further confirm LOBE-induced kallikrein activation specificity, the main procoagulant factors, FX and prothrombin (PThr), were depleted ...
http://www.buyresearchchemicalss.net/2019/12/supplementary-materialss1-methods-detailed-explanation-of-prekallikrein-production-and-prothrombinfactor-x/
Prothrombin, albumin and immunoglobulin A form covalent complexes with alpha1-microglobulin in human plasma - Lunds universitetProthrombin, albumin and immunoglobulin A form covalent complexes with alpha1-microglobulin in human plasma - Lunds universitet
Molecules containing the 33-kDa plasma protein alpha1-microglobulin were isolated from human plasma by anti-(alpha1-microglobulin) affinity chromatography. Five major bands could be seen after electrophoretic separation of the alpha1-microglobulin-containing proteins under native conditions. Immunoblotting demonstrated alpha1-microglobulin in all five bands. Two of these have been described previously: free alpha1-microglobulin and alpha1-microglobulin complexed with IgA (IgA x alpha1-microglobulin). The other three bands were identified as prothrombin alpha1-microglobulin, albumin x alpha1-microglobulin and dimeric alpha1-microglobulin. Prothrombin x alpha1-microglobulin were 1:2 and 1:1 complexes which carried approximately 1% of total alpha1-microglobulin, had molecular masses of about 145 kDa and 110 kDa upon SDS/PAGE and dissociated completely to free alpha1-microglobulin and prothrombin (72 kDa) when reducing agents were added, suggesting that the complexes were stabilized by disulfide ...
https://portal.research.lu.se/portal/sv/publications/prothrombin-albumin-and-immunoglobulin-a-form-covalent-complexes-with-alpha1microglobulin-in-human-plasma
Frequently Asked Questions
Individuals who carry the Factor V Leiden mutation have a 3- to 8-fold increased risk as heterozygotes and a greater than 10-fold increased risk as homozygotes. Individuals who carry the F2 prothrombin mutation have a 2- to 5-fold increased risk as heterozygotes and up to a 10-fold increased risk as homozygotes. Individuals who carry two copies of the 677C,T mutation, or one 677C,T and one 1298A,C mutation, in the MTHFR gene have between a 2- and 8-fold increased risk. Compound heterozygotes (heterozygous for more than one of the mutations tested for) have an even higher risk of thrombophilia. For example, a person that is heterozygous for both the Factor V Leiden mutation and heterozygous for the F2 prothrombin mutation has a greater than 20-fold increased risk ...
https://www.thrombosisdna.com/faqs/
blood coagulation, kringle domains, vitamin K-dependent protein, gene targeting, prothrombin deficiency, HNF-1. - Begell House...blood coagulation, kringle domains, vitamin K-dependent protein, gene targeting, prothrombin deficiency, HNF-1. - Begell House...
Prothrombin and thrombin are involved in diverse biological functions. The structure of prothrombin has been studied extensively and its cDNA has been cloned fr...
http://dl.begellhouse.com/journals/6dbf508d3b17c437,381b52fd786d6cd6,469410f3031e9dd8.html
Medications/Treatment
A prothrombin activity level of ~10% has been identified as the minimum level required for hemostasis per multiple national registries.27 However, to achieve and maintain hemostasis, FII troughs of 20% to 30% are recommended. The ideal method for replacement would be with a prothrombin concentrate. Unfortunately, prothrombin deficiency is one of the few RBDs without a dedicated factor concentrate for replacement.36 The mainstay of treatment for acute bleeding events or long-term prophylaxis remains prothrombin complex concentrates (PCC) or fresh frozen plasma (FFP).. FFP infusions at 15-20 ml/kg per dose can be used for acute bleeding and are expected to raise FII activity level by 25%.28 To maintain hemostasis in the post-surgical setting or in cases of severe bleeding, FFP at 3-10 ml/kg every 12-24 hours is advised to maintain safe and adequate correction.28,36,37 However the potential for volume overload with repeated FFP infusions could limit use in some patients with volume restrictions. ...
http://www.rarecoagulationdisorders.org/diseases/prothrombin-factor-ii-deficiency/medications-treatment
Thrombin - WikipediaThrombin - Wikipedia
Thrombin (EC 3.4.21.5, fibrinogenase, thrombase, thrombofort, topical, thrombin-C, tropostasin, activated blood-coagulation factor II, blood-coagulation factor IIa, factor IIa, E thrombin, beta-thrombin, gamma-thrombin) is a serine protease, an enzyme that, in humans, is encoded by the F2 gene. Prothrombin (coagulation factor II) is proteolytically cleaved to form thrombin in the clotting process. Thrombin in turn acts as a serine protease that converts soluble fibrinogen into insoluble strands of fibrin, as well as catalyzing many other coagulation-related reactions. After the description of fibrinogen and fibrin, Alexander Schmidt hypothesised the existence of an enzyme that converts fibrinogen into fibrin in 1872. Thrombin is produced by the enzymatic cleavage of two sites on prothrombin by activated Factor X (Xa). The activity of factor Xa is greatly enhanced by binding to activated Factor V (Va), termed the prothrombinase complex. Prothrombin is produced in the liver and is ...
https://en.wikipedia.org/wiki/Thrombin
Prothrombin Complex Concentrate (Human) [(Factors II, VII, IX, X), Protein C, and Protein S] (Professional Patient Advice) -...Prothrombin Complex Concentrate (Human) [(Factors II, VII, IX, X), Protein C, and Protein S] (Professional Patient Advice) -...
Professional guide for Prothrombin Complex Concentrate (Human) [(Factors II, VII, IX, X), Protein C, and Protein S]. Includes: pharmacology, pharmacokinetics, contraindications, interactions, adverse reactions and more.
https://www.drugs.com/ppa/prothrombin-complex-concentrate-human-factors-ii-vii-ix-x-protein-c-and-protein-s.html
Prothrombin Time (PT) | technoclone.comProthrombin Time (PT) | technoclone.com
Prothrombin Time (PT)The TECHNOPLASTIN® HIS and TECHNOCLOT® PT Series are thromboplastin reagents derived from rabbit. Thromboplastins are a mixture of tissue factor, phospholipid, and calcium.The Prothrombin Time (PT) is used to:· Screen for congenital or acquired deficiencies in the extrinsic and common pathways· Monitor warfarin therapy· Aid in the diagnosis of DIC· Aid in
https://technoclone.at/en/product/prothrombin-time-pt
Primary Diagnostics Laboratory: Prothrombin time with INR
Clinical Significance Screening test for abnormalities of coagulation factors that are involved in the extrinsic pathway. Also used to monitor effects of Warfarin therapy and to study patients with hereditary and acquired clotting disorders.. Algorithms. Test FAQ. Prothrombin Time with INR. Alternative Name(s) PT. Prothrombin Time with INR Collection Guide. Return to Cardiology. Return to Virtual Test Guide. The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the Payor being billed.. ...
http://primarydiagnosticslaboratory.com/virtual-test-guide/prothrombin-time-with-inr/
Anti-Prothrombin antibody (Biotin) | AbcamAnti-Prothrombin antibody (Biotin) | Abcam
Anti-Prothrombin antibody conjugated to Biotin validated for WB, IP, RIA, cELISA and tested in Human. Immunogen corresponding to full length native protein…
http://www.abcam.com/prothrombin-antibody-biotin-ab49554.html
Management of rivaroxaban- or apixaban-associated major bleeding with prothrombin complex concentrates: a cohort study | Blood ...Management of rivaroxaban- or apixaban-associated major bleeding with prothrombin complex concentrates: a cohort study | Blood ...
There is uncertainty regarding the effectiveness and occurrence of thromboembolic events in patients treated with prothrombin complex concentrates (PCCs) for the management of major bleeding events (MBEs) on rivaroxaban or apixaban. We investigated the effectiveness of PCCs given for the management of MBEs in patients on rivaroxaban or apixaban. Between 1 January 2014 and 1 October 2016, we prospectively included patients on rivaroxaban or apixaban treated with PCCs for the management of MBEs. The effectiveness of PCCs was assessed by using the International Society of Thrombosis and Hemostasis Scientific and Standardization Subcommittee criteria for the assessment of the effectiveness of major bleeding management. The safety outcomes were thromboembolic events and all-cause mortality within 30 days after treatment with PCCs. A total of 84 patients received PCCs for the reversal of rivaroxaban or apixaban due to a MBE. PCCs were given at a median (interquartile range) dose of 2000 IU (1500-2000 ...
https://ashpublications.org/blood/article/130/15/1706/36377/Management-of-rivaroxaban-or-apixabanassociated
Prothrombin Time Test in ghaziabad - Metropolis HealthcareProthrombin Time Test in ghaziabad - Metropolis Healthcare
Get accurate and quick report of Prothrombin Time Test in ghaziabad at your nearest Metropolis lab or your home at affordable cost. A Prothrombin time test is a test used to detect and diagnose bleeding disorder or clotting disorder in the body.
https://www.metropolisindia.com/parameter/ghaziabad/prothrombin-time-test
Prothrombin Time Test in Perumbavoor - Book Now - Metropolis HealthcareProthrombin Time Test in Perumbavoor - Book Now - Metropolis Healthcare
Metropolis offers Prothrombin Time Test in Perumbavoor at your nearest labs or your home. A prothrombin test is recommended for a bleeding disorder. Book now.
https://www.metropolisindia.com/parameter/perumbavoor/prothrombin-time-test
Prothrombin Complex Concentrates Market Boosted at 9.1% CAGR by 2025 due to Increasing Government Funding | Fortune Business...Prothrombin Complex Concentrates Market Boosted at 9.1% CAGR by 2025 due to Increasing Government Funding | Fortune Business...
The Global Prothrombin Complex Concentrates Market is likely to gain traction due to the significant drop in demand for its counterpart fresh frozen plasma (FFP). PCC is available easily due to its lack of blood group specificity.
https://marketersmedia.com/prothrombin-complex-concentrates-market-boosted-at-91-cagr-by-2025-due-to-increasing-government-funding-fortune-business-insights/513014
DailyMed - Search Results for Increased Prothrombin ActivityDailyMed - Search Results for Increased Prothrombin Activity
Due to inconsistencies between the drug labels on DailyMed and the pill images provided by RxImage, we no longer display the RxImage pill images associated with drug labels. We anticipate reposting the images once we are able identify and filter out images that do not match the information provided in the drug labels. ...
https://dailymed.nlm.nih.gov/dailymed/search.cfm?query=Increased%20Prothrombin%20Activity&searchdb=class
Pregnancy outcomes among women with inherited thrombophilia polymorphismsPregnancy outcomes among women with inherited thrombophilia polymorphisms
Asymptomatic, nulliparous, heterozygous carriers of the prothrombin gene mutation are 3.6 times as likely as women who do not carry the mutation to experience severe pregnancy complications.
https://www.contemporaryobgyn.net/view/pregnancy-outcomes-among-women-inherited-thrombophilia-polymorphisms
Acenocoumarol
Acenocoumarol is an oral anticoagulant of the coumarin series, synthesized and developed in the Geigy laboratoires in the late 1960s and sold in the United States under the brand name of Sintrom. It lowers the prothrombin level of the blood. It is a white crystalline powder without taste and odor and has a molecular weight of 353. It is soluble in alkaline solutions but only slightly soluble in water and organic solvents. Chemically, acenocoumarol is 3-(alpha-acetonyl-4-nitrobenzyl)-4-hydroxycoumarin. ...
http://science-naturalphenomena.blogspot.com/2014/03/acenocoumarol.html
Evaluation of New Operation for Morbid Obesity - SAGES Abstract ArchivesEvaluation of New Operation for Morbid Obesity - SAGES Abstract Archives
Aim of the work is to avoid vitamins and trace elements deficiency that commonly follow malabsorptve procedures and needs strict follow up for long times. Methods: The effect of our new procedure on different nutritional elements deficiency were evaluated from February 1999 to May 2005. They were 156 patients (122 females & 34 males) with mean age of 39.7 ? 9.2 and body mass index (BMI) 56 ? 22.1 and followed for six years till June 2011. For all patients excess weight loss, calcium, albumin, hemoglobin, iron, zinc, vitamin B12, and prothrombin concentration were done preoperatively three, six months and every year thereafter for six years ...
https://www.sages.org/meetings/annual-meeting/abstracts-archive/evaluation-of-new-operation-for-morbid-obesity/
Patent US4289498 - One-stage prothrombin assay and compositions useful therein - Google PatentsPatent US4289498 - One-stage prothrombin assay and compositions useful therein - Google Patents
A one-stage prothrombin assay which measures the exponential rate of thrombin production in thromboplastin-treated, recalcified plasma. A serum reagent reduces the lag time before thrombin production substantially to zero for both normal and abnormal plasma, thus allowing measurements to be made in just a few minutes.
http://www.google.com/patents/US4289498?dq=3657699
Colonoscopy Results Fade Quickly From Memory space: THURSDAY.Colonoscopy Results Fade Quickly From Memory space: THURSDAY.
John Medical and Medical center Center in Detroit. Within an ACS news discharge, he said its important for doctors to replicate important information to patients following a colonoscopy, including that which was done, the full total results and tips for follow-up care. One helpful approach is to provide individuals with a document to collect and keep in their files. Another suggestion is to send the results right to the patients major care doctor. Typically, doctors who perform colonoscopies wont send [results] until the primary care doctor requests it, but I understand of centers that are being proactive about it and currently doing this, Alame said.We prepared reconstituted plasma by mixing prothrombin-deficient plasma with the recombinant prothrombins, since the probands plasma had not been suitable for evaluation due to warfarin treatment. We noticed that the mutant and wild-type prothrombins were fully converted to thrombins in a similar manner by prothrombinase within five minutes . ...
http://healthmattersnh.net/colonoscopy-results-fade-quickly-from-memory-space-thursday/
Question on Lupus Anticoagulant Comp. A blood test returned with Dilute Prothrombin Time (DPT) 59.4 DPT Ratio 1.26.Question on Lupus Anticoagulant Comp. A blood test returned with Dilute Prothrombin Time (DPT) 59.4 DPT Ratio 1.26.
Question on "Lupus Anticoagulant Comp. A blood test returned with Dilute Prothrombin Time (DPT) 59.4 DPT Ratio 1.26. - Answered by a verified Doctor
https://www.justanswer.com/medical/3jy1c-question-lupus-anticoagulant-comp-blood-test-returned.html
Evaluation of the Accuracy of the INRatio Prothrombin Time (PT) Monitoring System With a New Test Strip for the Oral...Evaluation of the Accuracy of the INRatio Prothrombin Time (PT) Monitoring System With a New Test Strip for the Oral...
Evaluation of the Accuracy of the INRatio Prothrombin Time (PT) Monitoring System With a New Test Strip for the Oral Anticoagulation Therapy Patient in the Presence of Heparin and Low Molecular Weight Heparin (e.g., Enoxaparin or Dalteparin) (ECLIPSE 03 ...
https://clinicaltrials.gov/ct2/show/results/NCT00933738
Anti-F2 / Prothrombin / Thrombin Antibody | Rabbit anti-Human WB | LSBioAnti-F2 / Prothrombin / Thrombin Antibody | Rabbit anti-Human WB | LSBio
Thrombin antibody LS-C658904 is an unconjugated rabbit polyclonal antibody to human Thrombin (F2 / Prothrombin ). Validated for WB.
https://www.lsbio.com/antibodies/f2-antibody-prothrombin-antibody-thrombin-antibody-wb-western-ls-c658904/672642
Anti-F2 / Prothrombin / Thrombin Antibody | Rabbit anti-Human | LSBioAnti-F2 / Prothrombin / Thrombin Antibody | Rabbit anti-Human | LSBio
Thrombin antibody LS-C392770 is an unconjugated rabbit polyclonal antibody to human Thrombin (F2 / Prothrombin ). Validated for Peptide-ELISA and WB.
https://www.lsbio.com/antibodies/f2-antibody-prothrombin-antibody-thrombin-antibody-aa46-79-wb-western-ls-c392770/404963
Blood Test: Prothrombin Time (PT)
A prothrombin time (PT) test measures how long it takes for a clot to form in a blood sample. A clot is a thick lump of blood that the body produces to seal leaks, wounds, cuts, and scratches and prevent excessive bleeding.. The bloods ability to clot is a complex process involving platelets (also called thrombocytes) and proteins called clotting factors. Platelets are oval-shaped cells made in the bone marrow. Most clotting factors are made in the liver.. When a blood vessel breaks, platelets are first to the area to help seal the leak and temporarily stop or slow the bleeding. But for the clot to become strong and stable, the action of clotting factors is required.. The bodys clotting factors are numbered using the Roman numerals I through XII. They work together in a specialized sequence, almost like pieces of a puzzle. When the last piece is in place, the clot develops - but if even one piece is missing or defective, the clot cant form.. The PT test can be used to evaluate the action of ...
https://www.rchsd.org/health-articles/blood-test-prothrombin-time-pt/
Prothrombin Time and INR - WellSpan Health LibraryProthrombin Time and INR - WellSpan Health Library
Covers prothrombin time and INR tests to measure how long it takes blood to clot. Explains why tests are done, how they differ, and how to prepare. Includes possible results and what they may mean. Looks at what may affect test results.
http://www.wellspan.org/health-library/Document.aspx?id=hw203083
Prothrombin Time (PT/INR) Blood Test for Clotting TimeProthrombin Time (PT/INR) Blood Test for Clotting Time
A prothrombin time test tells you how long it takes your blood to clot. Learn what it looks for, when you might need one, and what the results mean.
https://www.webmd.com/a-to-z-guides/prothrombin-time-test
Biosystems prothrombin time (pt)Biosystems prothrombin time (pt)
Biosystems prothrombin time (pt) Reagents are stable until the expiry date shown on the label when stored tightly closed and ifcontaminations are prevented
https://www.sesmedikal.com/urun-etiketi/biosystems-prothrombin-time-pt/
Hematology: prothrombin time lab test | cats | Vetlexicon Felis from Vetlexicon | Definitive Veterinary IntelligenceHematology: prothrombin time lab test | cats | Vetlexicon Felis from Vetlexicon | Definitive Veterinary Intelligence
Find details on Hematology: prothrombin time in cats. Lab test paper including overview, sampling, tests, result data and more. All information is peer reviewed.
https://vetstream.com/treat/felis/labtest/hematology-prothrombin-time
Prothrombin Antibody, IgGProthrombin Antibody, IgG
Prothrombin Antibody, IgG,ARUP Laboratories is a national reference laboratory and a worldwide leader in innovative laboratory research and development. ARUP offers an extensive test menu of highly complex and unique medical tests in clinical and anatomic pathology. Owned by the University of Utah, ARUP Laboratories client,medicine,medical supply,medical supplies,medical product
http://www.bio-medicine.org/medicine-products/Prothrombin-Antibody--IgG-24282-1/
Stroke? - Medical Stories - Condition | Our HealthStroke? - Medical Stories - Condition | Our Health
In October 2008, I had been unconscious for 2+ days, found unconscious by my son, rushed to the E.R., regained consciousness a few days later (but basically unable to move, etc), and was (finally!) diagnosed through an MRI of having had a stroke:eek:. Even though they run in my family, I was only 46, so the hematologist that I went to see a few months later determined that I had an inherited condition called prothrombin gene mutation(which basically means that your blood clots a lot more than the average person). I have been on coumadin (a blood thinner) since the time of the stroke and I have been in and out of the hospital for the blood being too thin too many times to count. Recently, I collapsed at my boyfriends house, and he rushed me to the hospital and I needed 5 units of blood and a few units of plasma(I weigh 110lbs). Since there was no external bleeding, after many tests, they determined that I had an ulcer and/or various very thin blood elsewhere in my body ...
http://www.ourhealth.com/conditions/medical-stories/stroke-3
Patent US5413919 - Method for preparing from cultured cells a thromboplastic reagent suitable ... - Google PatentsPatent US5413919 - Method for preparing from cultured cells a thromboplastic reagent suitable ... - Google Patents
A method for preparing a thromboplastin reagent from cultured human cells comprising the steps of washing the cells with isotonic aqueous salt solution, lysing the cells by hypotonic shock, and resuspending the cell lysate in a diluent compatible with a one-stage prothrombin time determination to reach a concentration of about 0.5 to 3.0 mg/mL thromboplastin, whereby the cell lysate thromboplastin suspension produces a clot in a one stage prothrombin time test in about 10 to 15 seconds, with a mean normal prothrombin time of about 11-13 seconds, when added to citrated normal plasma in a volume ratio of about 2:1, such thromboplastin reagent being stable for at least 8 hours at 37 C. and for at least 5 days at 4 C.
http://www.google.com/patents/US5413919?dq=5,742,768
September 2016 - Hepatitis B FoundationSeptember 2016 - Hepatitis B Foundation
These tests become your new baseline that your doctor can refer too in the years ahead while monitoring your liver health.. Your baseline ultrasound should examine your liver and measure its portal vein (it should be under 12 mm) and spleen (it should be under 12 cm) to make sure its normal with no signs of cirrhosis or portal hypertension.. If you had cirrhosis before you cleared HBsAg: You need to be surveyed for liver cancer (with an ultrasound, alpha fetoprotein (AFP) blood test and a Des-gamma-carboxy prothrombin (DCP) test) every six months for at least five years, because cirrhosis puts you at high risk of liver cancer. Once an ultrasound finds no evidence of cirrhosis and all other tests are normal, including the cancer tests, then the testing can become less frequent and your doctor can prescribe a new monitoring schedule.. If youve had elevated liver enzymes (called ALT or SGPT) in the past, (higher than 19 in women and 30 in men), you need to continue to get tested every six ...
https://www.hepb.org/blog/2016/09/
Welcome to the Population Approach Group in Europe
Andreas Groth1, Judi M ss2, Tine M ller3, Steen Ingwersen1. 1Biomodelling, 2Medical and Science, NovoSeven Key Projects, 3Biostatistics, Novo Nordisk, Bagsv rd, Denmark Objectives: NN1731 is a recombinant analogue of activated human coagulation factor FVII (FVIIa). Preclinical studies have indicated increased activity of NN1731 compared to native FVIIa in thrombin generation; a key step in the pathway to blood coagulation [1]. Thrombin generation from prothrombin may be measured by the appearance in the blood of prothrombin fragments 1 & 2 (F1+2). A first human dose (FHD) trial investigated the safety and the PK of NN1731, including measurements of F1+2 in plasma. It was attempted to investigate the feasibility of establishing a population PK/PD model of NN1731 pharmacologic effect to enable a future estimation of a relative potency of NN1731 compared to native recombinant FVIIa (rFVIIa, NovoSeven®).. Methods: The FHD trial was a dose escalation trial with 4 cohorts of patients (5, 10, 20 and ...
https://www.page-meeting.org/?abstract=1195
Rabbit polyclonal to ZNF394
Supplementary MaterialsS1 Methods: Detailed explanation of prekallikrein production and prothrombin/factor X lacking plasma assays. Aliquots of 10 L PD184352 ic50 had been taken and generated kallikrein enzymatic activity was determined using the specific chromogenic substrate S2302 (2 mM). The kinetics of p-nitroaniline formation were monitored at 405 nm and curves are representative data from at least three independent experiments. Inset shows the dose-response curve. The amounts of plasma derived kallikrein generated by LOBE was estimated using a calibration curve made with known concentrations of purified kallikrein and thus expressed as pmol of equivalent kallikrein/mL/min.(TIF) pntd.0007197.s004.tif (459K) GUID:?7403B6A2-C7C2-4032-B696-330A483F7AED S4 Fig: LOBE-induced kallikrein generation in factor X and prothrombin deficient PD184352 ic50 plasma. To further confirm LOBE-induced kallikrein activation specificity, the main procoagulant factors, FX and prothrombin (PThr), were depleted ...
http://www.buyresearchchemicalss.net/tag/rabbit-polyclonal-to-znf394/
Pharma Guidelines Validations Clean Room Classification Sterile Aseptic Process Regulatory Guide: Factor Xa inhibitor for...Pharma Guidelines Validations Clean Room Classification Sterile Aseptic Process Regulatory Guide: Factor Xa inhibitor for...
factor Xa inhibitor treatment of deep vein thrombosis knee hip replacement surgery rivaroxaban Xarelto act up on prothrombin and convert prothrombin to thrombin
http://www.pharmacistspharmajournal.org/2011/07/new-drug-first-oral-factor-xa-inhibitor.html
Proteinase K Solution, 600 mAU/ml | 71049Proteinase K Solution, 600 mAU/ml | 71049
Proteinase K Solution, 600 mAU/ml Efficient removal of proteins from nucleic acid solutions - Find MSDS or SDS, a COA, data sheets and more information.
https://www.emdmillipore.com/CA/en/product/Proteinase-K-Solution-600-mAU-ml,EMD_BIO-71049
Reactome | prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase...Reactome | prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase...
Reactome is pathway database which provides intuitive bioinformatics tools for the visualisation, interpretation and analysis of pathway knowledge.
https://reactome.org/content/detail/R-HSA-140664
Native Bovine Thrombin(EC 3.4.21.5) - Creative EnzymesNative Bovine Thrombin(EC 3.4.21.5) - Creative Enzymes
Thrombin is a serine protease that in humans is encoded by the F2 gene. Prothrombin (coagulation factor II) is proteolytically cleaved to form thrombin in the coagulation
https://www.creative-enzymes.com/product/Native-Bovine-Thrombin_940.html
Ignas VėgėlėIgnas Vėgėlė
Partneris advokatas prof. dr. Ignas Vėgėlė yra Mykolo Romerio Universiteto profesorius, skaitantis paskaitas Europos Sąjungos teisės temomis bei vedantis seminarus Lietuvos teisininkams bei plačiajai visuomenei. Jis yra autorius ir bendraautorius mokslinių ir publicistinių straipsnių bei knygų. Vėliausios mokslinės knygos: „Europos Sąjungos teisė. Vidaus rinkos laisvės, konkurencija ir teisės derinimas 2011; „Aplinkosaugos teisė 2011; Europos Sąjungos teisė. Steigimo sutartys ir svarbiausi vidaus rinkos teisės aktai 2007; Vartotojų teisių apsauga Lietuvoje ir Europos Sąjungoje 2006, Įmonėms taikytina teisė ir pirminis steigimasis Europos Bendrijos teisėje 2002. Ignas Vėgėlė yra advokatų kvalifikacinių egzaminų komisijos narys, notarų kvalifikacinio egzamino komisijos narys, Lietuvos teisininkų draugijos pirmininkas.. Ignas Vėgėlė daugiau nei penkiolika metų dirba teisininko darbą. Jis yra dirbęs teisininko asistentu advokatų kontoroje Foresta ...
http://www.4law.lt/ignas-vegele/
Blood clotting - TIB MOLBIOLBlood clotting - TIB MOLBIOL
Coagulation is a complex process to form clots of platelets and fibrin to stop bleeding. After damage of a blood vessel a cascade of signals is initiated (extrinsic), starting with Factor (F) VII to activate FIX and FX and its cofactor FVa to release thrombin from prothrombin (FII), which allows to convert fibrinogen to fibrin and to crosslink it (through FXIII), but also activates FV, FVIII and their inhibitor protein C (compressed summary). Increased risk of bleeding and increased clotting (thrombosis) are well-known disorders of coagulation. There are several mutations in these genes known, having an influence on the coagulation. Most prominent is the FV variant R506Q, causing APC resistance and increasing the risk for thrombosis. Also well-known is the prothrombin (F2) G20210A mutation, increasing the risk for blood clots in the deep veins. ...
https://www.tib-molbiol.com/diagnostic-kits/properties/panel/blood-clotting.html
Blood test pt and ptt - Foods to thin blood
Eating foods that have vitamin K, such as broccoli, chickpeas, kale, turnip greens, and soybean products.Wrap an elastic band around your upper arm to stop the flow of blood.It may be ordered along with a prothrombin time (PT) test to evaluate.Sixty whole blood samples were collected into. tests (e.g., PT and PTT).INR (international normalized ratio) stands for a way of standardizing the results of prothrombin time tests, no matter the testing method.Reasons you may not be able to have the test or why the results may not be helpful include.You may feel nothing at all from the needle, or you may feel a quick sting or pinch.. The combination of both tests examines how the factors work together, and evaluation of both results together can help diagnose certain conditions.The PT and PTT Blood Tests are useful in the diagnosis of excessive, unexplained bleeding in patients who are not taking blood-thinning medications.A PTT test is commonly performed in conjunction with another clothing test called ...
http://www.catcountry947.com/nage/blood-test-pt-and-ptt-coc.php
Bruises Risk Factors : Learning Center on Healthline.comBruises Risk Factors : Learning Center on Healthline.com
A prothrombin time test measures how long it takes for your blood plasma to clot. Prothrombin, or factor II, is one of 12 proteins in the clotting process ...
https://www.aarpmedicareplans.com/channel/bruises_riskfactors
Blood Test: Prothrombin Time (PT)Blood Test: Prothrombin Time (PT)
Doctors may order a PT test as part of an evaluation for a bleeding disorder or to monitor the effects of blood-thinning medicine.
http://kidshealth.org/KidsHealthDemo/en/parents/test-pt.html
Prothrombin timeProthrombin time
"Test ID: PT Prothrombin Time, Plasma". D'Angelo A, Galli L, Lang H (1997). "Comparison of mean normal prothrombin time (PT) ... The prothrombin time ratio is the ratio of a subject's measured prothrombin time (in seconds) to the normal laboratory ... Indeed, a new prothrombin time variant, the Fiix prothrombin time, intended solely for monitoring warfarin and other vitamin K ... The prothrombin time (PT) - along with its derived measures of prothrombin ratio (PR) and international normalized ratio (INR ...
https://en.wikipedia.org/wiki/Prothrombin_time
Prothrombin activatorProthrombin activator
... is a complex of a dozen blood coagulation factors that functions in catalyzing prothrombin into thrombin ... Prothrombin activator is released in the body by a cascade of chemical reactions in response to damage in a blood vessel. ...
https://en.wikipedia.org/wiki/Prothrombin_activator
Prothrombin G20210AProthrombin G20210A
Measurement of an elevated plasma prothrombin level cannot be used to screen for the prothrombin G20210A mutation, because ... untranslated region of the prothrombin gene is associated with elevated plasma prothrombin levels and an increase in venous ... Because prothrombin is also known as factor II, the mutation is also sometimes referred to as the factor II mutation or simply ... Prothrombin G20210A was identified in the 1990s. About 2% of Caucasians carry the variant, while it is less common in other ...
https://en.wikipedia.org/wiki/Prothrombin_G20210A
Prothrombin complex concentrateProthrombin complex concentrate
... (PCC), also known as factor IX complex, is a medication made up of blood clotting factors II, ... Prothrombin complex concentrate came into medical use in the 1960s. It is on the World Health Organization's List of Essential ... Prothrombin complex concentrate reverses the effects of warfarin and other vitamin K antagonist anti-coagulants and is used in ... Prothrombin complex concentrate contains a number of blood clotting factors. Typically this includes factor II, IX, and X. Some ...
https://en.wikipedia.org/wiki/Prothrombin_complex_concentrate
Prothrombin fragment 1+2Prothrombin fragment 1+2
... (F1+2), also written as prothrombin fragment 1.2 (F1.2), is a polypeptide fragment of prothrombin ( ... Páramo JA (2010). "Prothrombin fragments in cardiovascular disease". Adv Clin Chem. 51: 1-23. doi:10.1016/s0065-2423(10)51001-1 ... Krishnaswamy S (June 2013). "The transition of prothrombin to thrombin". J Thromb Haemost. 11 Suppl 1: 265-76. doi:10.1111/jth. ... It is released from the N-terminus of prothrombin. F1+2 is a marker of thrombin generation and hence of coagulation activation ...
https://en.wikipedia.org/wiki/Prothrombin_fragment_1 2
AntithrombinAntithrombin
Seegers WH, Johnson JF, Fell C (1954). "An antithrombin reaction to prothrombin activation". Am. J. Physiol. 176 (1): 97-103. ... prothrombin) and factor Xa. Antithrombin is also termed antithrombin III (AT III). The designations antithrombin I through to ...
https://en.wikipedia.org/wiki/Antithrombin
ThrombinThrombin
Prothrombin was discovered by Pekelharing in 1894. Thrombin is produced by the enzymatic cleavage of two sites on prothrombin ... Prothrombin G20210A is congenital. Prothrombin G20210A is not usually accompanied by other factor mutations (i.e., the most ... Prothrombin complex concentrate and fresh frozen plasma are prothrombin-rich coagulation factor preparations that can be used ... Activation of prothrombin is crucial in physiological and pathological coagulation. Various rare diseases involving prothrombin ...
https://en.wikipedia.org/wiki/Thrombin
FenoprofenFenoprofen
Anticoagulants: Coadministration may prolong prothrombin time. Aspirin: Fenoprofen Cl may be increased; coadministration is not ...
https://en.wikipedia.org/wiki/Fenoprofen
Anti-thrombin aptamersAnti-thrombin aptamers
As a result, TBA prolongs the prothrombin time when interacting with prothrombin. TBA entered the phase I clinical trial for ... Ecarin activates prothrombin and accordingly produces meizothrombin. The exosite II is not accessible in meizothrombin, so thus ... Furthermore, TBA recognizes and inhibits prothrombin with similar affinity against alpha-thrombin. ... Binds Exosite 1 on Prothrombin with High Affinity and Inhibits Its Activation by Prothrombinase". Journal of Biological ...
https://en.wikipedia.org/wiki/Anti-thrombin_aptamers
Johan StenfloJohan Stenflo
Kresge N, Simoni RD, Hill RL (May 2009). "The Finding That Prothrombin Contains γ-Carboxyglutamic Acid: the Work of Johan ... Fernlund P, Stenflo J, Roepstorff P, Thomsen J (August 1975). "Vitamin K and the biosynthesis of prothrombin. V. Gamma- ... In 1975, he published a classic paper on the biosynthesis of prothrombin. His doctoral students include Björn Dahlbäck. ... carboxyglutamic acids, the vitamin K-dependent structures in prothrombin". J. Biol. Chem. 250 (15): 6125-33. PMID 50323. v t e ...
https://en.wikipedia.org/wiki/Johan_Stenflo
CoagulaseCoagulase
... reacts with prothrombin in the blood. The resulting complex is called staphylothrombin, which enables the enzyme to ...
https://en.wikipedia.org/wiki/Coagulase
HemostasisHemostasis
Blood tests: Prothrombin time Partial thromboplastin time "hemostasis". Merriam-Webster Dictionary. Retrieved 2016-01-21. " ...
https://en.wikipedia.org/wiki/Hemostasis
Peptic ulcer diseasePeptic ulcer disease
Prothrombin complex concentrates are preferred for severe bleeding. Recombinant factor VIIa is reserved for life-threatening ... For those who were under warfarin treatment, fresh frozen plasma (FFP), vitamin K, prothrombin complex concentrates, or ...
https://en.wikipedia.org/wiki/Peptic_ulcer_disease
Björn DahlbäckBjörn Dahlbäck
In 1981 he received from Lund University his doctorate with dissertation The activation of prothrombin on the platelet surface ... Dahlbäck, Björn (1981). The activation of prothrombin on the platelet surface. Malmö. "Professeur Björn Dahlbäck, Laureate de ...
https://en.wikipedia.org/wiki/Björn_Dahlbäck
Vitamin K deficiency bleedingVitamin K deficiency bleeding
Bleeding in an infant without vitamin K supplementation with elevated prothrombin time (PT) that is corrected by vitamin K ... Severe bleeding may require blood products such as fresh frozen plasma (FFP), a prothrombin complex concentrate (PCC). Sutor, ... administration which restores the prothrombin time rapidly. ...
https://en.wikipedia.org/wiki/Vitamin_K_deficiency_bleeding
EdoxabanEdoxaban
Prothrombinases turn prothrombins to thrombins. Thrombins turn blood-soluble fibrinogens to insoluble fibrins, which are the ...
https://en.wikipedia.org/wiki/Edoxaban
CirrhosisCirrhosis
Prothrombin time increases, since the liver synthesizes clotting factors. Globulins increase due to shunting of bacterial ... Clotting function is estimated by lab values, mainly platelet count, prothrombin time (PT), and international normalized ratio ...
https://en.wikipedia.org/wiki/Cirrhosis
Sandra J. F. DegenSandra J. F. Degen
Prothrombin is a coagulation factor critical in the initial steps of blood clotting. They prepared the human prothrombin from ... Several years later, after isolating cDNA for prothrombin from mice, they were able to characterize the complete prothrombin ... Genetic elimination of prothrombin in adult mice is not compatible with survival and results in spontaneous hemorrhagic events ... Prothrombin deficiency results in embryonic and neonatal lethality in mice Proceedings of the National Academy of Sciences of ...
https://en.wikipedia.org/wiki/Sandra_J._F._Degen
Rabbit hemorrhagic diseaseRabbit hemorrhagic disease
Prolonged prothrombin and activated partial thromboplastin times are typical. Urinalysis can show bilirubinuria, proteinuria, ...
https://en.wikipedia.org/wiki/Rabbit_hemorrhagic_disease
ZileutonZileuton
This can lead to an increase in prothrombin time. Zileuton is an active oral inhibitor of the enzyme 5-lipoxygenase, which ... although significant increase in prothrombin time is not obvious. It is advised that the doses of each medication be monitored ...
https://en.wikipedia.org/wiki/Zileuton
Liver diseaseLiver disease
In liver disease, prothrombin time is longer than usual. In addition, the amounts of both coagulation factors and ... serum proteins, serum albumin, serum globulin, alanine transaminase, aspartate transaminase, prothrombin time, partial ...
https://en.wikipedia.org/wiki/Liver_disease
Cerebral angiographyCerebral angiography
Meanwhile, prothrombin time is assessed to rule out coagulopathy. Informed consent regarding the risks of the procedure is ...
https://en.wikipedia.org/wiki/Cerebral_angiography
Eastern brown snakeEastern brown snake
One of the main components of the venom is the prothrombinase complex pseutarin-C, which breaks down prothrombin. John White, ... Pseutarin-C is a procoagulant in the laboratory, but ultimately an anticoagulant in snakebite victims, as the prothrombin is ... Manjunatha Kini, R.; Morita, T.; Rosing, J. (2001). "Classification and nomenclature of prothrombin activators isolated from ... This cleaves prothrombin at two sites, converting it to thrombin. ...
https://en.wikipedia.org/wiki/Eastern_brown_snake
ThrombophiliaThrombophilia
Two years later, the same group described a common mutation in the prothrombin gene that caused elevation of prothrombin levels ... untranslated region of the prothrombin gene is associated with elevated plasma prothrombin levels and an increase in venous ... The prothrombin mutation occurs at rates of 1-4% in the general population, 5-10% of people with thrombosis, and 15% of people ... The most common ones are factor V Leiden (a mutation in the F5 gene at position 1691) and prothrombin G20210A, a mutation in ...
https://en.wikipedia.org/wiki/Thrombophilia
Livedo reticularisLivedo reticularis
"Livedo Vasculopathy Associated with IgM Anti-phosphatidylserine-prothrombin Complex Antibody". Acta Dermato Venereologica. 90 ( ... in a patient with sarcoidosis and Sjögren's syndrome Livedo vasculopathy associated with IgM antiphosphatidylserine-prothrombin ... complex antibody Livedo vasculopathy associated with plasminogen activator inhibitor-1 promoter homozygosity and prothrombin ...
https://en.wikipedia.org/wiki/Livedo_reticularis
Liver function testsLiver function tests
Prothrombin time (PT) and its derived measures of prothrombin ratio (PR) and INR are measures of the extrinsic pathway of ... These tests include prothrombin time (PT/INR), activated Partial Thromboplastin Time (aPTT), albumin, bilirubin (direct and ... "Prothrombin Time Test and INR (PT/INR): MedlinePlus Medical Test". medlineplus.gov. Retrieved 25 February 2021. Kingston, ...
https://en.wikipedia.org/wiki/Liver_function_tests
Thrombosis preventionThrombosis prevention
These same herbal supplements taken with warfarin increased prothrombin time. By containing significant content of vitamin K, ...
https://en.wikipedia.org/wiki/Thrombosis_prevention
WarfarinWarfarin
The effects of warfarin typically should be monitored by checking prothrombin time (INR) every one to four weeks. Many other ... Chai-Adisaksopha C, Hillis C, Siegal DM, Movilla R, Heddle N, Iorio A, Crowther M (October 2016). "Prothrombin complex ... The effects of warfarin may be reversed with phytomenadione (vitamin K1), fresh frozen plasma, or prothrombin complex ... prothrombin complex concentrate (PCC), or fresh frozen plasma (FFP) Generally, four-factor PCC can be given more quickly than ...
https://en.wikipedia.org/wiki/Warfarin
MalabsorptionMalabsorption
Prolonged prothrombin time can be caused by vitamin K deficiency. Serological studies. Specific tests are carried out to ...
https://en.wikipedia.org/wiki/Malabsorption
ParacentesisParacentesis
The risk of bleeding may be increased if: prothrombin time > 21 seconds international normalized ratio > 1.6 platelet count < ...
https://en.wikipedia.org/wiki/Paracentesis
Prothrombin thrombophilia: MedlinePlus GeneticsProthrombin thrombophilia: MedlinePlus Genetics
Prothrombin thrombophilia is an inherited disorder of blood clotting. Explore symptoms, inheritance, genetics of this condition ... The particular mutation that causes prothrombin thrombophilia results in an overactive F2 gene that causes too much prothrombin ... Prothrombin thrombophilia is caused by a particular mutation in the F2 gene. The F2 gene plays a critical role in the formation ... People who have prothrombin thrombophilia are at somewhat higher than average risk for a type of clot called a deep venous ...
https://medlineplus.gov/genetics/condition/prothrombin-thrombophilia/
Weight-Based Prothrombin Stops Warfarin-Induced BleedingWeight-Based Prothrombin Stops Warfarin-Induced Bleeding
On the basis of these results, "we are going to continue using the weight-based prothrombin complex concentrate," she explained ... "We use a weight-based dosing regimen based on studies from similar prothrombin complex concentrations, but not factor VIII ... Previous studies have suggested that a fixed-dose regimen of activated prothrombin complex concentrate factor VIII inhibitor ... He also suggested that the normalization of prothrombin time or INR might not be the right target. ...
http://www.medscape.com/viewarticle/859791
Hypoxia-induced des-gamma-carboxy prothrombin production in hepatocellular carcinomaHypoxia-induced des-gamma-carboxy prothrombin production in hepatocellular carcinoma
Des-gamma-carboxy prothrombin (DCP) is an established HCC tumor marker, but the precise mechanism of its production is still ... Des-gamma-carboxy prothrombin (DCP) is an established HCC tumor marker, but the precise mechanism of its production is still ... Hypoxia-induced des-gamma-carboxy prothrombin production in hepatocellular carcinoma Int J Oncol. 2010 Jan;36(1):161-70. ...
https://pubmed.ncbi.nlm.nih.gov/19956845/?dopt=AbstractPlus
Prothrombin and Activated Partial Thromboplastin Reagents | Fisher ScientificProthrombin and Activated Partial Thromboplastin Reagents | Fisher Scientific
Browse a full range of Prothrombin and Activated Partial Thromboplastin Reagents products from leading suppliers. Shop now at ... Prothrombin and Activated Partial Thromboplastin Reagents. Prothrombin and Activated Partial Thromboplastin Reagents. Reagents ... For use in prothrombin time (PT) determinations and prothrombin time-based assays in citrated human plasma. ... Thermo Scientific™ Pacific Hemostasis™ Prothrombin Time (PT) Reagents GSA/VA Contract. Available on GSA/VA contract for Federal ...
https://www.fishersci.com/us/en/browse/90222109/prothrombin-and-activated-partial-thromboplastin-reagents?page=1
Anti-Human Prothrombin | 52-MA-HFIIAnti-Human Prothrombin | 52-MA-HFII
Anti-Human Prothrombin Manufactured by Gentaur. Gentaur is the biggest antibody manufacturer worldwide. ... Anti-Human Prothrombin , Gentaur. (No reviews yet) Write a Review Write a Review. ...
https://anobase.org/anti-human-prothrombin-gentaur/
Technical standards and guidelines: Venous thromboembolism (Factor V Leiden and prothrombin 20210G|A testing): A disease...Technical standards and guidelines: Venous thromboembolism (Factor V Leiden and prothrombin 20210G|A testing): A disease...
FV/PT 2.6.2 Factor II (Prothrombin 20210G,A). The prothrombin 20210G,A mutation is located in the 3′ untranslated region of the ... FV/PT 3.12.2.2.4 Prothrombin 20210G,A homozygote. The number of individuals reported to be homozygous for the prothrombin ... FV/PT 3.12.2.2.2 Prothrombin 20210G,A heterozygote. Individuals heterozygous for the prothrombin 20210G,A mutation have an ... A common genetic variation in the 3-untranslated region of the prothrombin gene is associated with elevated plasma prothrombin ...
https://www.nature.com/articles/gim200584?error=cookies_not_supported&code=630c3cf5-df09-4ec2-a999-b9c23e7f2f52
Role of prothrombin 19911 A|G polymorphism, blood group and male gender in patients with venous thromboembolism: Results of a...Role of prothrombin 19911 A|G polymorphism, blood group and male gender in patients with venous thromboembolism: Results of a...
G polymorphism at position 19911 in the prothrombin gene (factor [F] 2 at rs3136516) as a risk factor for venous ... G polymorphism at position 19911 of the prothrombin gene, e.g. F2 at rs3136516, located in intron 13 of the prothrombin gene is ... untranslated region of the prothrombin gene is associated with elevated plasma prothrombin levels and an increase in venous ... The association of prothrombin A19911G polymorphism with plasma prothrombin activity and venous thrombosis: results of the MEGA ...
https://link.springer.com/article/10.1007/s11239-020-02169-6
Plasma co-administration improves resuscitation with tranexamic acid or prothrombin complex from the SAGES Video LibraryPlasma co-administration improves resuscitation with tranexamic acid or prothrombin complex from the SAGES Video Library
... prothrombin complex, repurfusion injury, resuscitation, rotational thromboelastometry, ROTEM, super ciliac cross clamping, ...
https://www.sages.org/video/plasma-co-administration-improves-resuscitation-with-tranexamic-acid-or-prothrombin-complex/
Prothrombin time (PT) test and INR| Health Navigator NZProthrombin time (PT) test and INR| Health Navigator NZ
Find out more about what are prothrombin time (PT) test & INR, why are they performed, test result and interpretation. ... Health A-Z / P / Prothrombin time (PT) test & INR Prothrombin time (PT) test and INR. Print *. A. ... Prothrombin time in seconds. Prothrombin time is usually measured in seconds, that is, the time it takes for your blood to clot ... Prothrombin time as a ratio - INR. Because the results of the prothrombin time test vary from laboratory to laboratory, a ratio ...
https://www.healthnavigator.org.nz/health-a-z/p/prothrombin-time-pt-test-inr/
Thông tin thuốc của Prothrombin complex concentrate, Human | MIMS VietnamThông tin thuốc của Prothrombin complex concentrate, Human | MIMS Vietnam
Prothrombin complex concentrate, Human: Belongs to the class of blood coagulation factors. Used in the treatment of hemorrhage ... Assess prothrombin time/INR, aPTT, and clotting factor assays prior to, during, and after therapy. Watch out for signs and ... Thông báo miễn trừ trách nhiệm: Thông tin này được MIMS biên soạn một cách độc lập dựa trên thông tin của Prothrombin complex ... Description: Prothrombin concentrate complex (PCC) is a factor IX preparation from human plasma containing variable amount of ...
https://www.mims.com/vietnam/drug/info/prothrombin%20complex%20concentrate,%20human?mtype=generic
Prothrombin (Factor II) 20210 Gene Mutation - Hematology and Oncology - Merck Manuals Professional EditionProthrombin (Factor II) 20210 Gene Mutation - Hematology and Oncology - Merck Manuals Professional Edition
Prothrombin (Factor II) 20210 Gene Mutation - Etiology, pathophysiology, symptoms, signs, diagnosis & prognosis from the Merck ... of the prothrombin genes at position 20210 results in increased plasma prothrombin levels (with potentially increased thrombin ... Prothrombin (factor II) is a vitamin K-dependent precursor of thrombin, the terminal enzyme of the coagulation cascade (see ... A genetic mutation causes increased plasma levels of prothrombin (factor II), predisposing to venous thrombosis. ...
https://www.merckmanuals.com/en-pr/professional/hematology-and-oncology/thrombotic-disorders/prothrombin-factor-ii-20210-gene-mutation
Use of viscoelastic monitoring and prothrombin complex concentrate in a paediatric patient with polytrauma and severe traumatic...Use of viscoelastic monitoring and prothrombin complex concentrate in a paediatric patient with polytrauma and severe traumatic...
Use of viscoelastic monitoring and prothrombin complex concentrate in a paediatric patient with polytrauma and severe traumatic ... Use of viscoelastic monitoring and prothrombin complex concentrate in a paediatric patient with polytrauma and severe traumatic ... Use of viscoelastic monitoring and prothrombin complex concentrate in a paediatric patient with polytrauma and severe traumatic ...
https://casereports.bmj.com/content/13/12/e236608.info
Genetic Associations for Activated Partial Thromboplastin Time and Prothrombin Time, their Gene Expression Profiles, and Risk...
Genetic Associations for Activated Partial Thromboplastin Time and Prothrombin Time, their Gene Expression Profiles, and Risk ...
https://www.research.ed.ac.uk/en/publications/genetic-associations-for-activated-partial-thromboplastin-time-an/projects/?status=FINISHED
BlackBoxRX • Prothrombin Complex Concentrate (Human)BlackBoxRX • Prothrombin Complex Concentrate (Human)
Prothrombin Complex Concentrate (Human). Arterial and Venous Thromboembolic Complications. *Patients being treated with Vitamin ...
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Micropathology: Prothrombin and Factor V MutationsMicropathology: Prothrombin and Factor V Mutations
Prothrombin and Factor V Mutations. Genetic risk factors for venous thrombosis include two relatively common mutations: c.1601G ... The cost of this assay is per sample, for both the Factor V Leiden and Prothrombin G20210A mutations combined. ... Combined effect of Factor V Leiden and Prothrombin Pooled analysis of 8 case-control studies including 2310 cases and 3204 ... Factor V Leiden and G20210A Prothrombin mutations are risk factors for very early recurrent miscarriage. Further information ...
https://www.micropathology.com/services-genetic-prothrombin.php
Rat Factor II (Prothrombin) Purified - Innovative ResearchRat Factor II (Prothrombin) Purified - Innovative Research
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Prothrombin | Profiles RNS
"Prothrombin" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical Subject ... This graph shows the total number of publications written about "Prothrombin" by people in UAMS Profiles by year, and whether " ... It is converted to thrombin by a prothrombin activator complex consisting of factor Xa, factor V, phospholipid, and calcium ... Below are the most recent publications written about "Prothrombin" by people in Profiles over the past ten years. ...
https://uams-triprofiles.uams.edu/profiles/display/102000
Outcomes Following Three-Factor Inactive Prothrombin Complex Concentrate Versus Recombinant Activated Factor VII Administration...
Dive into the research topics of Outcomes Following Three-Factor Inactive Prothrombin Complex Concentrate Versus Recombinant ... Objective: To compare outcomes following inactive prothrombin complex concentrate (PCC) or recombinant activated factor VII ( ... N2 - Objective: To compare outcomes following inactive prothrombin complex concentrate (PCC) or recombinant activated factor ... AB - Objective: To compare outcomes following inactive prothrombin complex concentrate (PCC) or recombinant activated factor ...
https://mayoclinic.pure.elsevier.com/en/publications/outcomes-following-three-factor-inactive-prothrombin-complex-conc
Factor II (Prothrombin), DNA Analysis | LabCorp - Find Lab Tests Online
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ZYMUTEST™ Anti-Prothrombin IgG | HYPHEN BIOMEDZYMUTEST™ Anti-Prothrombin IgG | HYPHEN BIOMED
ELISA method, specific for quantitative determination of Anti-Prothrombin, IgG.. Please contact your local distributor for more ...
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VWD Diagnosis | CDCVWD Diagnosis | CDC
Prothrombin Time (PT) Test. This test also measures the time it takes for blood to clot. It measures primarily the clotting ...
https://www.cdc.gov/ncbddd/vwd/diagnosis.html
Prevalence of anti-cardiolipin, anti-β2 glycoprotein I, and anti-prothrombin antibodies in young patients with epilepsy<...
Prevalence of anti-cardiolipin, anti-β2 glycoprotein I, and anti-prothrombin antibodies in young patients with epilepsy. In: ... Purpose: To measure anti-cardiolipin (aCL), anti-β2 glycoprotein I (anti-β2GPI), and anti-prothrombin (aPT) antibodies in young ... Prevalence of anti-cardiolipin, anti-β2 glycoprotein I, and anti-prothrombin antibodies in young patients with epilepsy. ... Dive into the research topics of Prevalence of anti-cardiolipin, anti-β2 glycoprotein I, and anti-prothrombin antibodies in ...
https://moh-it.pure.elsevier.com/en/publications/prevalence-of-anti-cardiolipin-anti-%CE%B22-glycoprotein-i-and-anti-pr
Hepatic vein waveform and splenomegaly predict improvement of prothrombin time after splenectomy in hepatitis C virus-related...
Total bilirubin and prothrombin time were significantly improved after splenectomy in patients with HVWF type I, however, they ... Total bilirubin and prothrombin time were significantly improved after splenectomy in patients with HVWF type I, however, they ... Total bilirubin and prothrombin time were significantly improved after splenectomy in patients with HVWF type I, however, they ... Total bilirubin and prothrombin time were significantly improved after splenectomy in patients with HVWF type I, however, they ...
https://kyushu-u.pure.elsevier.com/en/publications/hepatic-vein-waveform-and-splenomegaly-predict-improvement-of-pro
Acute Liver Failure Workup: Approach Considerations, Laboratory Studies, Blood CulturesAcute Liver Failure Workup: Approach Considerations, Laboratory Studies, Blood Cultures
Prothrombin time (PT). The PT and/or the international normalized ratio (INR) are used to determine the presence and severity ... with clinical or laboratory evidence of moderate or severe acute hepatitis should have immediate measurement of prothrombin ...
https://emedicine.medscape.com/article/177354-workup
Weight-Based Prothrombin Stops Warfarin-Induced Bleeding
On the basis of these results, "we are going to continue using the weight-based prothrombin complex concentrate," she explained ... "We use a weight-based dosing regimen based on studies from similar prothrombin complex concentrations, but not factor VIII ... Previous studies have suggested that a fixed-dose regimen of activated prothrombin complex concentrate factor VIII inhibitor ... He also suggested that the normalization of prothrombin time or INR might not be the right target. ...
https://www.staging.medscape.com/viewarticle/859791
Prothrombin TimeProthrombin Time
... Does this test have other names?. Prothrombin time/PT, Pro time, Prothrombin time/International normalized ... The prothrombin time test measures how quickly prothrombin changes to thrombin to stop the bleeding. If the prothrombin doesnt ... Prothrombin is one type of clotting factor. When bleeding occurs in the body, prothrombin quickly changes to thrombin. ... The prothrombin time is 1 of several tests that check if your blood is clotting normally. Blood clotting (coagulation) is ...
https://betterhealth.saintpetershcs.com/RelatedItems/167,pt_prothrombin_time
Prothrombin Time Test Faridabad | Prothrombin Time Test Price & Cost Faridabad | CNC PathlabProthrombin Time Test Faridabad | Prothrombin Time Test Price & Cost Faridabad | CNC Pathlab
Know about the Prothrombin Time Test Price & Cost Faridabad. ... CNC Pathlab offers a wide range of Prothrombin Time Test ... Prothrombin Time Test Faridabad. A prothrombin time (PT) test measures how long it takes for a clot to form in a blood sample. ... A Prothrombin Time Test help to check the liver problem and provides you with a clear picture of whats wrong with your body. ... Prothrombin is a protein made by the liver. It is one of several substances known as clotting (coagulation) factors. When you ...
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IMSEAR at SEARO: A case of prothrombin complex deficiency.
A case of prothrombin complex deficiency. Indian Pediatrics. 1968 Jan; 5(1): 35-9. ...
https://imsear.searo.who.int/handle/123456789/11465?locale=es
Four-Factor Prothrombin Complex Concentrate for Urgent Reversal of Vitamin K Antagonists in Patients With Major Bleeding -...
Four-Factor Prothrombin Complex Concentrate for Urgent Reversal of Vitamin K Antagonists in Patients With Major Bleeding ...
https://experts.mcmaster.ca/display/publication763278
Prothrombin Fragment 1+2Prothrombin Fragment 1+2
To take full advantage of this site, please enable your browsers JavaScript feature. Learn how ...
https://www.econolabs.com/product-p/lc-500016.htm
ThrombinConcentrateDeficiencyInternational normaG20210AMutation20210Prolonged prothrombin timeCoagulation factorsLaboratoryFibrinogenAnti-ProthrombinConcentratesLiverThrombophiliaFactor V LeidFragmentAPTTHeparinTestVenous thromboembolismReagentPatientsHepaticPhospholipidVitamin K-dependentPolymorphismBloodDescriptorHuman
Thrombin12
  • The protein produced from the F2 gene, prothrombin (also called coagulation factor II), is the precursor to a protein called thrombin that initiates a series of chemical reactions in order to form a blood clot. (medlineplus.gov)
  • An abundance of prothrombin leads to more thrombin, which promotes the formation of blood clots. (medlineplus.gov)
  • It is converted to thrombin by a prothrombin activator complex consisting of factor Xa, factor V, phospholipid, and calcium ions. (uams.edu)
  • When bleeding occurs in the body, prothrombin quickly changes to thrombin. (saintpetershcs.com)
  • The prothrombin time test measures how quickly prothrombin changes to thrombin to stop the bleeding. (saintpetershcs.com)
  • Two sites on prothrombin are enxymatically cleaved by activated factor X (factor Xa) to yield thrombin. (medscape.com)
  • The assay determines the time (in seconds) during which a thrombus-producing protein called thrombin is produced from inactive prothrombin in the blood plasma taken for analysis. (synevo.ge)
  • 2006). Prothrombin is activated by factor X and V to form active thrombin. (preventiongenetics.com)
  • 1.20), a normal prothrombin ratio at 90%, a normal plasma thrombin time, a hemoglobin at 13.3 g/dL and a normal platelet level at 306G/L. Then, a diagnosis of acquired hemophilia was made. (lww.com)
  • Mouse and human prothrombin (ProT) active site specifically labeled with D-Phe-Pro-Arg-CH2Cl (FPR-ProT) inhibited tissue factor-initiated thrombin generation in platelet-rich and platelet-poor mouse and human plasmas. (auburn.edu)
  • b) Activates prothrombin to thrombin. (bankofbiology.com)
  • The thrombin is a protein substance produced through a conversion reaction in which prothrombin of bovine origin is activated by tissue thromboplastin of bovine-origin in the presence of calcium chloride. (nih.gov)
Concentrate7
  • Patients who presented to our institution with life-threatening bleeds who were on warfarin prior to admission and who were treated with a weight-based activated prothrombin complex concentrate achieved reversal of their international normalized ratio [INR] significantly faster than patients who received fresh frozen plasma only," said lead investigator Elizabeth Messana, PharmD, from the Detroit Medical Center Detroit Receiving Hospital. (medscape.com)
  • On the basis of these results, "we are going to continue using the weight-based prothrombin complex concentrate," she explained. (medscape.com)
  • Prothrombin concentrate complex (PCC) is a factor IX preparation from human plasma containing variable amount of factor II, VII and X. It rapidly increases the plasma levels of the vitamin K-dependent coagulation factors and temporarily correct the coagulation defect in patient with deficiency of these factors. (mims.com)
  • Objective: To compare outcomes following inactive prothrombin complex concentrate (PCC) or recombinant activated factor VII (rFVIIa) administration during cardiac surgery. (elsevier.com)
  • He was found to have a hepatic hematoma and was given activated prothrombin complex concentrate (aPCC) of 14 150 units of anti-inhibitor coagulant complex at 100 units per kilogram due to concern for active hemorrhage. (amjcaserep.com)
  • Rivaroxaban reversal with prothrombin complex concentrate or tranexamic acid in healthy volunteers. (thieme-connect.de)
  • Four factor prothrombin complex concentrate (4F-PCC) is FDA approved to reverse vitamin K antagonists (VKAs) such as warfarin in adult patients with acute major bleeding or a need for an urgent surgery/invasive procedure. (pharmacy-pearls.org)
Deficiency13
  • Deficiency of prothrombin leads to hypoprothrombinemia. (uams.edu)
  • IMSEAR at SEARO: A case of prothrombin complex deficiency. (who.int)
  • Agarwal KN, Hussain QZ, Berry AM. A case of prothrombin complex deficiency. (who.int)
  • Complete prothrombin deficiency has not been reported in humans. (medscape.com)
  • The observation that prothrombin-null mice die in utero or shortly after birth suggests that complete deficiency of factor II is incompatible with life. (medscape.com)
  • Patients with Factor II deficiency typically have prolonged partial thromboplastin time (PTT) and prothrombin time (PT). (preventiongenetics.com)
  • Congenital prothrombin/Factor II deficiency is an inherited bleeding disorder. (preventiongenetics.com)
  • 2012). Complete deficiency of prothrombin is incompatible with life (Sun et al. (preventiongenetics.com)
  • In severe forms of prothrombin deficiency, intracranial hemorrhage or umbilical bleeding may present and be life threatening. (preventiongenetics.com)
  • Prothrombin deficiency is inherited in an autosomal recessive manner through mutations in the F2 gene. (preventiongenetics.com)
  • Missense mutations are causative for prothrombin deficiency in ~80% of cases and primarily disrupt the catalytic serine protease domain (Akavan et al. (preventiongenetics.com)
  • Deficiency of prothrombin (factor II) can be either inherited or acquired. (japer.in)
  • The inherited ‎Prothrombin deficiency is considered as one of the rarest bleeding disorders. (japer.in)
International norma6
  • If your answer is yes, then you may need a Program Prothrombin Time (PT) or also known as an International Normalized Ratio (INR). (comforthha.com)
  • Prothrombin time is measured in seconds, but can be expressed in different ways: seconds (sec), prothrombin index in percent (%) and INR (International Normalized Ratio). (synevo.ge)
  • Note 1:** Physician statement of the International Normalized Ratio for Prothrombin Time (INR) can be used to code this data item when no other information is available. (cancer.gov)
  • International normalized ratio for prothrombin time (INR), one of the tests, measures the liver's ability to make blood clotting factors. (cancer.gov)
  • Prolonged prothrombin time (PT) and international normalized ratio (INR) (24 to 72 hours after exposure) persisting for weeks to months, as determined by hospital laboratory tests. (cdc.gov)
  • One test of liver function is the prothrombin time (PT), which is used to calculate the international normalized ratio (INR). (msdmanuals.com)
G20210A8
  • Clinical and laboratory management of the prothrombin G20210A mutation. (medlineplus.gov)
  • Genetic risk factors for venous thrombosis include two relatively common mutations: c.1601G>A p.R534Q (previously referred to as R506Q) in exon 10 of the human Factor V gene (commonly known as the Factor V Leiden mutation) and c.*97G>A (frequently referred to as G20210A) in the 3' untranslated region of the Prothrombin gene. (micropathology.com)
  • Factor V Leiden and G20210A Prothrombin mutations are risk factors for very early recurrent miscarriage. (micropathology.com)
  • The cost of this assay is per sample, for both the Factor V Leiden and Prothrombin G20210A mutations combined. (micropathology.com)
  • A C677T methylenetetrahydrofolate reductase (MTHFR) polymorphism and G20210A mutation in the prothrombin gene of sickle cell anemia patients from Northeast Brazil. (fiocruz.br)
  • The C677T methylenetetrahydrofolate reductase (MTHFR) gene polymorphism and the G20210A mutation at the 3' untranslated region (3'UTR) of the prothrombin gene may be considered to be genetic risk factors that contribute to the clinical heterogeneity in sickle cell disease. (fiocruz.br)
  • Are the rates of recurrent VTE higher in adults with VTE who possess either the factor V Leiden (FVL) or Prothrombin G20210A mutation, and what are the rates of VTE among family members? (the-hospitalist.org)
  • Predictive value of factor V Leiden and prothrombin G20210A in adults with venous thromboembolism and in family members of those with a mutation: a systematic review. (the-hospitalist.org)
Mutation8
  • Prothrombin thrombophilia is caused by a particular mutation in the F2 gene. (medlineplus.gov)
  • The particular mutation that causes prothrombin thrombophilia results in an overactive F2 gene that causes too much prothrombin to be produced. (medlineplus.gov)
  • The risk of developing an abnormal clot in a blood vessel depends on whether a person inherits one or two copies of the F2 gene mutation that causes prothrombin thrombophilia. (medlineplus.gov)
  • Prothrombin 20210 mutation (factor II mutation). (medlineplus.gov)
  • A genetic mutation causes increased plasma levels of prothrombin (factor II), predisposing to venous thrombosis. (merckmanuals.com)
  • None Factor II (Prothrombin), DNA Analysis test cost minimal is in EconoLabs (Factor II (Prothrombin Mutation), DNA Analysis) with price $335.00. (findlabtest.com)
  • Prothrombin 20210 GA gene mutation leads to increases in prothrombin. (medscape.com)
  • It was once believed that prothrombin gene mutation might have a relationship with inflammatory bowel disease ( Crohn disease or ulcerative colitis ), but research efforts have not found evidence of such a relationship. (medscape.com)
202105
  • The diagnosis is made by genetic analysis of the prothrombin 20210 gene using blood samples. (merckmanuals.com)
  • Factor II (Prothrombin) G 20210 A Most common inherited coagulation disorder in U. S. Autosomal dominant inheritance. (present5.com)
  • Factor II (Prothrombin) G 20210 A Assay A. Extraction- Mag. (present5.com)
  • NA Pure LC DNA Isolation Kit I and instrument (Roche Diagnostics) B. Amplification/ Detection/ Genotyping= factor II (Prothrombin G 20210 A Kit and Light. (present5.com)
  • Real time PCR (or Amplification or detection) Target- 165 bp fragment of Factor II gene Factor II (Prothrombin) G 20210 A kit- master mix reagents primers and probes) Light. (present5.com)
Prolonged prothrombin time4
  • INR is useful only in anticoagulant therapy and is not used to diagnose and treat patients with prolonged prothrombin time for other reasons. (synevo.ge)
  • Prolonged prothrombin time (PT) is a laboratory blood test result showing that blood clots too slowly which makes the patient subject to abnormal bleeding. (glutenfreeworks.com)
  • The presence of CVD, chronic kidney disease, prolonged prothrombin time and elevated lactate dehydrogenase (LDH) were associated with mortality. (who.int)
  • Mortality from COVID-19 was associated with having CVD, chronic kidney disease, elevated LDH and prolonged prothrombin time. (who.int)
Coagulation factors3
  • [ 1 ] Prothrombin differs from other coagulation factors in that it is only minimally affected by pregnancy. (medscape.com)
  • The measurement of prothrombin time and INR is used as an initial screening test to detect deficiencies of one or more coagulation factors (Factors I, II, V, VII, X) as well as to monitor patients on anticoagulation. (athenslab.gr)
  • It blocks the actions of certain blood proteins and enzymes (such as vitamin k reductase, prothrombin, coagulation factors VII, IX, X and protein C) that forms blood clots in the body. (netmeds.com)
Laboratory6
  • The results of the prothrombin test vary depending on the laboratory, the test chemicals used in different laboratories and the method used to test blood. (healthnavigator.org.nz)
  • Because the results of the prothrombin time test vary from laboratory to laboratory, a ratio called the international normalised ratio (INR) is calculated. (healthnavigator.org.nz)
  • Purpose: To measure anti-cardiolipin (aCL), anti-β 2 glycoprotein I (anti-β2GPI), and anti-prothrombin (aPT) antibodies in young patients with epilepsy, and to correlate their presence with demographic data, clinical diagnoses, laboratory and neuroradiologic findings, and antiepileptic drugs (AEDs). (elsevier.com)
  • All patients with clinical or laboratory evidence of moderate or severe acute hepatitis should have immediate measurement of prothrombin time (PT) and careful evaluation of the mental status. (medscape.com)
  • The aim of this report was to present a case of interference on prothrombin time (PT) test that directed further laboratory diagnostics and resulted with final detection of monoclonal gammopathy in an 88-year old man. (biochemia-medica.com)
  • Baseline laboratory investigations in the form of complete blood count, prothrombin time, partial thromboplastin time, platelet count, electrocardiogram, and X-ray chest were done. (marinemedicalsociety.in)
Fibrinogen2
  • These factors include fibrinogen (factor I), prothrombin (factor II) and factors V, VII, and X. If the patient's blood is deficient in one of these factors, the patient's PT (measured in seconds) will be higher than the control PT (measured in seconds). (athenslab.gr)
  • 1%, a von Willebrand factor risen to 142%, no anomaly regarding the complement system (C3/C4/CH50), a negative rheumatoid factor, a normal prothrombin time and finally a normal fibrinogen activity. (lww.com)
Anti-Prothrombin1
  • ELISA method, specific for quantitative determination of Anti-Prothrombin, IgG. (hyphen-biomed.com)
Concentrates1
  • Corwin HL, Shander A. Conjecture and Fact: Prothrombin Complex Concentrates for Bleeding With Vitamin K Antagonists. (uams.edu)
Liver4
  • Prothrombin is a protein made by the liver. (cncpathlab.com)
  • A Prothrombin Time Test help to check the liver problem and provides you with a clear picture of what's wrong with your body. (cncpathlab.com)
  • Prothrombin Is a protein synthesized by the liver and is one of the important factors that promotes blood clotting. (synevo.ge)
  • Being vitamin K it helps blood clotting by producing prothrombin and therefore treats hemophilia, excessive bleeding and liver function. (healtharticlesmagazine.com)
Thrombophilia8
  • Prothrombin thrombophilia is an inherited disorder of blood clotting. (medlineplus.gov)
  • Most people with prothrombin thrombophilia never develop abnormal blood clots, however. (medlineplus.gov)
  • Some research suggests that prothrombin thrombophilia is associated with a somewhat increased risk of pregnancy loss (miscarriage) and may also increase the risk of other complications during pregnancy. (medlineplus.gov)
  • It is important to note, however, that most women with prothrombin thrombophilia have normal pregnancies. (medlineplus.gov)
  • Prothrombin thrombophilia is the second most common inherited form of thrombophilia after factor V Leiden thrombophilia . (medlineplus.gov)
  • Approximately 1 in 50 people in the white population in the United States and Europe has prothrombin thrombophilia. (medlineplus.gov)
  • Other factors also increase the risk of blood clots in people with prothrombin thrombophilia. (medlineplus.gov)
  • The combination of prothrombin thrombophilia and mutations in other genes involved in blood clotting can also influence risk. (medlineplus.gov)
Factor V Leid2
  • Combined effect of Factor V Leiden and Prothrombin Pooled analysis of 8 case-control studies including 2310 cases and 3204 controls. (micropathology.com)
  • Additional tests include chromogen (amidolytic) based assay - the formation of chromogenic colour is proportional to the amount of Activated protein-C - APC (hence Protein-C) in the plasma sample specimen (test results can be interfered with by hemolysis, lipemia, icterus etc), partially activated Protein-C test, antithrombin, lupus anticoagulant, antiphospholipid antibodies, factor V Leiden test, prothrombin test etc. (rtdiagnostics.net)
Fragment1
  • Quantitative determination of prothrombin fragment F 1+2 in human plasma. (fishersci.com)
APTT1
  • Reagents used to perform prothrombin time (PT) and activated partial thromboplastin time (aPTT) tests on clinical blood samples. (fishersci.com)
Heparin2
  • Hypersensitivity to prothrombin complex and heparin. (mims.com)
  • All Prothrombin Time (PT) with an INR ≥ 5.0 will be reflexed to Heparin Neutralization and reported with the comment attached: "This PT/INR result is from a specimen treated with Heparin Adsorbent and allows the physician to determine approximate values. (aclab.com)
Test12
  • A prothrombin time (PT) test is a blood test that measures how long it takes your blood to clot. (healthnavigator.org.nz)
  • Prothrombin time test results can be presented either in seconds or as a ratio (INR). (healthnavigator.org.nz)
  • What is a prothrombin time test? (healthnavigator.org.nz)
  • If you need more than just Factor II (Prothrombin), DNA Analysis lab test - add more tests one by one. (findlabtest.com)
  • Factor II (Prothrombin), DNA Analysis test cost max is in Walk-In Lab (Factor II (Prothrombin), DNA Analysis Blood Test) with price $500.00. (findlabtest.com)
  • You can secure some fantastic Prothrombin Time Test Faridabad for a complete diagnosis of body check-up. (cncpathlab.com)
  • If you are scared of spending hefty amounts on Prothrombin Time Test price , then let us inform you that you can enjoy a nice price cut at Pathlab in Faridabad. (cncpathlab.com)
  • Sincerity, Innovation, Rigorousness, and Efficiency" is the persistent conception of our firm for the long-term to create jointly with consumers for mutual reciprocity and mutual reward for Low Prothrombin Time, Paediatric Blood Gas Analysis , Chemistry Analyzer , At Home Hormone Test , Normal Bleeding And Clotting Time . (pmdtbio.com)
  • Prothrombin time (PT) is the most frequently performed global coagulation test. (biochemia-medica.com)
  • Prothrombin time (PT) is a test that helps doctors diagnose excessive clotting or bleeding disorder. (esteroislandmedicalcare.com)
  • Q: What does the prothrombin time (PT) test measure? (glutenfreeworks.com)
  • Prothrombin time (PT) test - This test measures the time it takes for blood to clot. (beaumont.org)
Venous thromboembolism1
  • G polymorphism at position 19911 in the prothrombin gene (factor [F] 2 at rs3136516) as a risk factor for venous thromboembolism [VTE] is still unclear. (springer.com)
Reagent1
  • Prothrombin time reagent containing thromboplastin and calcium chloride is mixed with the patient plasma and the time to clot formation is measured photo-optically. (walkinlab.com)
Patients7
  • Bosler D, Mattson J, Crisan D. Phenotypic Heterogeneity in Patients with Homozygous Prothrombin 20210AA Genotype. (medlineplus.gov)
  • Prothrombin time, serum albumin and total bilirubin concentrations were reviewed before and after splenectomy and analyzed to clarify whether splenectomy improves hepatic function in patients with cirrhosis and to determine the factors predictive of improvement in hepatic function. (elsevier.com)
  • Twelve months after splenectomy, total serum bilirubin had decreased by over 0.3mg/dL in 52.3% of patients and prothrombin time had improved by over 10% in 52.3% of patients. (elsevier.com)
  • Total bilirubin and prothrombin time were significantly improved after splenectomy in patients with HVWF type I, however, they were not improved in patients with HVWF type II. (elsevier.com)
  • Conclusion: Prothrombin time and total bilirubin improve in approximately half of cirrhotic patients within a year after splenectomy. (elsevier.com)
  • HVWF type I and splenomegaly may be predictive factors for improvement in prothrombin time after splenectomy in patients with cirrhosis due to hepatitis C. (elsevier.com)
  • Prothrombin time and INR are monitored in the point of care for patients taking oral anticoagulants, which allow physicians to adjust medications levels to the prescribed therapeutic or target range. (umich.edu)
Hepatic1
  • Multiple linear regression analysis identified hepatic vein waveform (HVWF) type I (P=0.0174) and spleen weight (P=0.0394) as independent predictors of improvement in prothrombin time and preoperative total serum bilirubin (P=0.0002) as the only independent predictor of decrease in total bilirubin. (elsevier.com)
Phospholipid1
  • Ten glutamic acids on prothrombin are converted by vitamin K to gamma-carboxyglutamic acid (Gla) residues, the effect of which is to promote prothrombin binding to phospholipid bilayers when calcium is present. (medscape.com)
Vitamin K-dependent1
  • This drug interferes with the production of vitamin K-dependent coagulants, such as prothrombin. (athenslab.gr)
Polymorphism1
  • G polymorphism at position 19911 of the prothrombin gene, e.g. (springer.com)
Blood5
  • Prothrombin time is usually measured in seconds, that is, the time it takes for your blood to clot. (healthnavigator.org.nz)
  • The prothrombin time is 1 of several tests that check if your blood is clotting normally. (saintpetershcs.com)
  • If the prothrombin doesn't change as quickly as normal, you may have a blood clotting disorder. (saintpetershcs.com)
  • Prevent irregular blood clots with the aid of Prothrombin time. (comforthha.com)
  • Reduced prothrombin time Means accelerated blood clotting and has no clinical significance. (synevo.ge)
Descriptor1
  • Prothrombin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (uams.edu)
Human1
  • For use in prothrombin time (PT) determinations and prothrombin time-based assays in citrated human plasma. (fishersci.com)