Ferric Compounds: Inorganic or organic compounds containing trivalent iron.Molecular Structure: The location of the atoms, groups or ions relative to one another in a molecule, as well as the number, type and location of covalent bonds.Sulfur Compounds: Inorganic or organic compounds that contain sulfur as an integral part of the molecule.Volatile Organic Compounds: Organic compounds that have a relatively high VAPOR PRESSURE at room temperature.Structure-Activity Relationship: The relationship between the chemical structure of a compound and its biological or pharmacological activity. Compounds are often classed together because they have structural characteristics in common including shape, size, stereochemical arrangement, and distribution of functional groups.Plant Extracts: Concentrated pharmaceutical preparations of plants obtained by removing active constituents with a suitable solvent, which is evaporated away, and adjusting the residue to a prescribed standard.Drug Evaluation, Preclinical: Preclinical testing of drugs in experimental animals or in vitro for their biological and toxic effects and potential clinical applications.Magnetic Resonance Spectroscopy: Spectroscopic method of measuring the magnetic moment of elementary particles such as atomic nuclei, protons or electrons. It is employed in clinical applications such as NMR Tomography (MAGNETIC RESONANCE IMAGING).Phenols: Benzene derivatives that include one or more hydroxyl groups attached to the ring structure.Heterocyclic Compounds: Ring compounds having atoms other than carbon in their nuclei. (Grant & Hackh's Chemical Dictionary, 5th ed)Inhibitory Concentration 50: The concentration of a compound needed to reduce population growth of organisms, including eukaryotic cells, by 50% in vitro. Though often expressed to denote in vitro antibacterial activity, it is also used as a benchmark for cytotoxicity to eukaryotic cells in culture.Biphenyl CompoundsSulfhydryl Compounds: Compounds containing the -SH radical.Small Molecule Libraries: Large collections of small molecules (molecular weight about 600 or less), of similar or diverse nature which are used for high-throughput screening analysis of the gene function, protein interaction, cellular processing, biochemical pathways, or other chemical interactions.Organotin Compounds: Organic compounds which contain tin in the molecule. Used widely in industry and agriculture.Aniline CompoundsSpiro Compounds: A group of compounds consisting in part of two rings sharing one atom (usually a carbon) in common.Nitrogen Compounds: Inorganic compounds that contain nitrogen as an integral part of the molecule.Chromatography, High Pressure Liquid: Liquid chromatographic techniques which feature high inlet pressures, high sensitivity, and high speed.Stereoisomerism: The phenomenon whereby compounds whose molecules have the same number and kind of atoms and the same atomic arrangement, but differ in their spatial relationships. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)Drug Design: The molecular designing of drugs for specific purposes (such as DNA-binding, enzyme inhibition, anti-cancer efficacy, etc.) based on knowledge of molecular properties such as activity of functional groups, molecular geometry, and electronic structure, and also on information cataloged on analogous molecules. Drug design is generally computer-assisted molecular modeling and does not include pharmacokinetics, dosage analysis, or drug administration analysis.Dose-Response Relationship, Drug: The relationship between the dose of an administered drug and the response of the organism to the drug.Nitroso CompoundsOrganometallic Compounds: A class of compounds of the type R-M, where a C atom is joined directly to any other element except H, C, N, O, F, Cl, Br, I, or At. (Grant & Hackh's Chemical Dictionary, 5th ed)Organoselenium Compounds: Organic compounds which contain selenium as an integral part of the molecule.Drug Screening Assays, Antitumor: Methods of investigating the effectiveness of anticancer cytotoxic drugs and biologic inhibitors. These include in vitro cell-kill models and cytostatic dye exclusion tests as well as in vivo measurement of tumor growth parameters in laboratory animals.Organophosphorus Compounds: Organic compounds that contain phosphorus as an integral part of the molecule. Included under this heading is broad array of synthetic compounds that are used as PESTICIDES and DRUGS.Azo CompoundsGas Chromatography-Mass Spectrometry: A microanalytical technique combining mass spectrometry and gas chromatography for the qualitative as well as quantitative determinations of compounds.Kinetics: The rate dynamics in chemical or physical systems.Epoxy Compounds: Organic compounds that include a cyclic ether with three ring atoms in their structure. They are commonly used as precursors for POLYMERS such as EPOXY RESINS.Volatilization: A phase transition from liquid state to gas state, which is affected by Raoult's law. It can be accomplished by fractional distillation.High-Throughput Screening Assays: Rapid methods of measuring the effects of an agent in a biological or chemical assay. The assay usually involves some form of automation or a way to conduct multiple assays at the same time using sample arrays.Quaternary Ammonium Compounds: Derivatives of ammonium compounds, NH4+ Y-, in which all four of the hydrogens bonded to nitrogen have been replaced with hydrocarbyl groups. These are distinguished from IMINES which are RN=CR2.Drug Discovery: The process of finding chemicals for potential therapeutic use.Polycyclic Compounds: Compounds consisting of two or more fused ring structures.p-Methoxy-N-methylphenethylamine: A potent mast cell degranulator. It is involved in histamine release.Hydrocarbons, Aromatic: Organic compounds containing carbon and hydrogen in the form of an unsaturated, usually hexagonal ring structure. The compounds can be single ring, or double, triple, or multiple fused rings.Antineoplastic Agents: Substances that inhibit or prevent the proliferation of NEOPLASMS.Enzyme Inhibitors: Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction.Mass Spectrometry: An analytical method used in determining the identity of a chemical based on its mass using mass analyzers/mass spectrometers.Benzyl CompoundsOrganic Chemicals: A broad class of substances containing carbon and its derivatives. Many of these chemicals will frequently contain hydrogen with or without oxygen, nitrogen, sulfur, phosphorus, and other elements. They exist in either carbon chain or carbon ring form.Terphenyl Compounds: Compounds consisting of benzene rings linked to each other in either ortho, meta or para positions. Permitted are any substitutions, but ring fusion to any of the benzene rings is not allowed.Cell Line, Tumor: A cell line derived from cultured tumor cells.TriterpenesFurans: Compounds with a 5-membered ring of four carbons and an oxygen. They are aromatic heterocycles. The reduced form is tetrahydrofuran.Oxidation-Reduction: A chemical reaction in which an electron is transferred from one molecule to another. The electron-donating molecule is the reducing agent or reductant; the electron-accepting molecule is the oxidizing agent or oxidant. Reducing and oxidizing agents function as conjugate reductant-oxidant pairs or redox pairs (Lehninger, Principles of Biochemistry, 1982, p471).Molecular Conformation: The characteristic three-dimensional shape of a molecule.Allyl CompoundsModels, Molecular: Models used experimentally or theoretically to study molecular shape, electronic properties, or interactions; includes analogous molecules, computer-generated graphics, and mechanical structures.Spectrophotometry, Ultraviolet: Determination of the spectra of ultraviolet absorption by specific molecules in gases or liquids, for example Cl2, SO2, NO2, CS2, ozone, mercury vapor, and various unsaturated compounds. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)Glycosides: Any compound that contains a constituent sugar, in which the hydroxyl group attached to the first carbon is substituted by an alcoholic, phenolic, or other group. They are named specifically for the sugar contained, such as glucoside (glucose), pentoside (pentose), fructoside (fructose), etc. Upon hydrolysis, a sugar and nonsugar component (aglycone) are formed. (From Dorland, 28th ed; From Miall's Dictionary of Chemistry, 5th ed)Heterocyclic Compounds, 2-Ring: A class of organic compounds containing two ring structures, one of which is made up of more than one kind of atom, usually carbon plus another atom. The heterocycle may be either aromatic or nonaromatic.PicratesSpectrophotometry, Infrared: Spectrophotometry in the infrared region, usually for the purpose of chemical analysis through measurement of absorption spectra associated with rotational and vibrational energy levels of molecules. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)Selenium Compounds: Inorganic compounds that contain selenium as an integral part of the molecule.Plant Bark: The outer layer of the woody parts of plants.Plants, Medicinal: Plants whose roots, leaves, seeds, bark, or other constituent parts possess therapeutic, tonic, purgative, curative or other pharmacologic attributes, when administered to man or animals.Anti-Bacterial Agents: Substances that reduce the growth or reproduction of BACTERIA.Quantitative Structure-Activity Relationship: A quantitative prediction of the biological, ecotoxicological or pharmaceutical activity of a molecule. It is based upon structure and activity information gathered from a series of similar compounds.Indicators and Reagents: Substances used for the detection, identification, analysis, etc. of chemical, biological, or pathologic processes or conditions. Indicators are substances that change in physical appearance, e.g., color, at or approaching the endpoint of a chemical titration, e.g., on the passage between acidity and alkalinity. Reagents are substances used for the detection or determination of another substance by chemical or microscopical means, especially analysis. Types of reagents are precipitants, solvents, oxidizers, reducers, fluxes, and colorimetric reagents. (From Grant & Hackh's Chemical Dictionary, 5th ed, p301, p499)Biotransformation: The chemical alteration of an exogenous substance by or in a biological system. The alteration may inactivate the compound or it may result in the production of an active metabolite of an inactive parent compound. The alterations may be divided into METABOLIC DETOXICATION, PHASE I and METABOLIC DETOXICATION, PHASE II.Trialkyltin Compounds: Organometallic compounds which contain tin and three alkyl groups.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Cell Line: Established cell cultures that have the potential to propagate indefinitely.Plant Components, Aerial: The above-ground plant without the roots.Flavonoids: A group of phenyl benzopyrans named for having structures like FLAVONES.Bicyclo CompoundsBiodegradation, Environmental: Elimination of ENVIRONMENTAL POLLUTANTS; PESTICIDES and other waste using living organisms, usually involving intervention of environmental or sanitation engineers.Chromatography, Thin Layer: Chromatography on thin layers of adsorbents rather than in columns. The adsorbent can be alumina, silica gel, silicates, charcoals, or cellulose. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)Microbial Sensitivity Tests: Any tests that demonstrate the relative efficacy of different chemotherapeutic agents against specific microorganisms (i.e., bacteria, fungi, viruses).SesquiterpenesDiterpenes: Twenty-carbon compounds derived from MEVALONIC ACID or deoxyxylulose phosphate.Biological Products: Complex pharmaceutical substances, preparations, or matter derived from organisms usually obtained by biological methods or assay.
Siderophores, compounds of low molecular mass with high affinities for ferric iron, are important virulence factors in ... The HPI upon which the genes encoding the Ybt biosynthesis proteins are located is controlled by a series of molecular ... Because of its high affinity for iron, yersiniabactin can solubilize the metal bound to host binding proteins and transport it ... Miller, M. C.; Parkin, S.; Fetherston, J. D.; Perry, R. D.; Demoll, E. (2006). "Crystal structure of ferric-yersiniabactin, a ...
A common ferric compound is ferric chloride (FeCl3). In qualitative inorganic analysis, the presence of ferric ion can be ... The word ferric is derived from the Latin word ferrum for iron. Many proteins contain ferric ions. Examples include iron-sulfur ... In water, ferric iron forms compounds that are often insoluble, at least near neutral pH. A salt of ferric iron hydrolyzes ... Rust, a mixture of ferric hydroxide compounds, illustrates the low solubility of ferric ions in water. Various reagents cause ...
In iron chelation, insoluble ferric oxide compounds are solubilized in aqueous solutions. As bioavailability of iron is scarce ... an electrode or external metal compound). While these proteins are diverse (taking on both membrane-bound or soluble forms), ... Two commonly observed acceptors are iron compounds (specifically Fe(III) oxides) and manganese compounds (specifically Mn(III/ ... Flavins have also been hypothesized to bind to terminal electron transfer proteins as co-factors to increase oxidation rates. ...
Several proteins in human blood bind to hemin, such as hemopexin and serum albumin. A lyophilised form of hemin is used as a ... Hemin (haemin; ferric chloride heme) is an iron-containing porphyrin with chlorine that can be formed from a heme group, such ... Chemically, hemin differs from the related heme-compound hematin chiefly in that the coordinating ion is a chloride ion in ... The iron ion in haem is ferrous (Fe2+), whereas it is ferric (Fe3+) in both hemin and hematin. Hemin is endogenously produced ...
... and uptake of ferric Enterobactin and its hydrolytic cleavage to release Fe3+ into the cell. This production of this compound ... Khalil, S.; Pawelek, P. D. (17 December 2010). "Enzymatic Adenylation of 2,3-Dihydroxybenzoate Is Enhanced by a ProteinProtein ... The length of each monomer is 248 residues and the weight of the protein is 24647 Da. Each monomer consists of 7 beta-pleated ... Although the structure of the binding protein is not clearly defined, it was proposed that the binding pocket is made out of ...
The N3 of the imidazole compound binds to the heme iron atom of ferric cytochrome P450, whereas the N4 of the triazoles bind to ... Histidine is present in many proteins and enzymes and plays a vital part in the structure and binding functions of hemoglobin. ... The compound is classified as aromatic due to the presence of a sextet of π-electrons, consisting of a pair of electrons from ... Imidazole is a highly polar compound, as evidenced by its electric dipole moment of 3.67 D. It is highly soluble in water. ...
Flematti, Gavin R.; Ghisalberti, Emilio L.; Dixon, Kingsley W.; Trengove, R. D. (2004). "A compound from smoke that promotes ... Anaerobic soil microorganisms in aquatic environments use nitrate, manganese ions, ferric ions, sulfate, carbon dioxide, and ... Differences between hagfish species provide another example of adaptation to deep-sea pressure through specialized protein ... by converting hydrogen sulfide into water or other sulfur compounds (for example, 2H2S + CO2 + hv → CH2O + H2O + 2S). Early ...
The compound is used in the preparation of models for the prosthetic group in heme proteins. It is a dark purple solid that is ... When treated with ferric chloride in hot acetic acid solution, it forms the square pyramidal complex Fe(OEP)Cl. It also forms ... Octaethylporphyrin (H2OEP) is an organic compound that is a relative of naturally occurring heme pigments. ...
... is a naturally occurring organic compound that is used primarily as a flavor enhancer. It is found in the bark of larch ... D.M. Reffitt; T.J. Burden; P.T. Seed; J. Wood J; R.P. Thompson; J.J. Powell (2000). "Assessment of iron absorption from ferric ... "New Insights into the Interactions of Serum Proteins with Bis(maltolato)oxovanadium(IV): Transport and Biotransformation of ... "Chemistry and pharmacokinetics of gallium maltolate, a compound with high oral gallium bioavailability". Metal Based Drugs. 7 ...
When heated, the proteins in blood are altered, allowing them to combine with the iron in the blood, whilst the carbonate ... This theory explained why all elements react in the way they do and why some formed the compounds they do, while others did not ... ferric ferrocyanide. Finally, adding spirit of salt (hydrochloric acid) draws out a brilliant colour: Prussian blue. Ever since ... Yet, if water could be made by burning inflammable air, then water is not an element, but a compound. However, it simply did ...
Compound I + ROH + H2O CCP-compound I + e− + H+ → Compound II Compound II + e− + H+ → CCP CCP in the resting state has a ferric ... Unusual for proteins, this enzyme crystallizes when dialysed against distilled water. More so, the enzyme purifies as a ... Compound I of CCP is fairly long-lived, decaying to CCP-compound II with a half-life at room temperature of 40 minutes to a ... forming first a Compound I and then a Compound II intermediate: CCP + ROOH → ...
Naturally occurring compounds may also induce or inhibit CYP activity. For example, bioactive compounds found in grapefruit ... Cytochromes P450 (CYPs) are proteins of the superfamily containing heme as a cofactor and, therefore, are hemeproteins.[1] CYPs ... This pathway entails oxidation of the ferric-substrate complex with oxygen-atom donors such as peroxides and hypochlorites.[13] ... or just Compound I). This highly reactive intermediate was isolated in 2010,[12] P450 Compound 1 is an iron(IV) oxo (or ferryl ...
The most known compounds are petroleum products and yellow organic pigments. It is also an essential compound in the production ... Methemoglobinemia (higher presence of methemoglobin, the inactive ferric form of red blood cell heme) results in decreased ... including metabolic activation that results in binding of reactive metabolites to DNA and proteins, mutagenicity, oxidative DNA ... The compound was also found to be of low toxicity in rabbits following acute dermal exposure with an LD50 of 3235 mg/kg ...
In 2010, Lippard received the Ronald Breslow Award for his work on nonheme iron proteins. Also exciting was the synthesis of a ... Lippard has used X-ray diffraction and a variety of other methods to study such compounds, greatly expanding our understanding ... Although no particular use is known for the ferric wheel, it and subsequent ring-shaped homometallic molecular clusters are of ... Another novel complex was a "ferric triple-decker", containing three parallel triangular iron units and a triple bridge of six ...
... some companies have replaced the metallic iron in their products with an iron compound such as iron (III) phosphate, ferric ... protein meal bars and protein shakes. There are eleven varieties of Special K Protein Meal Bars: Mocha Crunch Protein, ... Special K Protein Meal Bars, Special K Protein Shakes, Special K Breakfast Shakes, Special K Protein Granola Bars, Special K ... The second meal of the diet included either a Special K Protein Meal Bar, Special K Protein Shake, or another serving of ...
In the deep oceans, iron-oxidizing bacteria derive their energy needs by oxidizing ferrous iron (Fe2+) to ferric iron (Fe3+). ... It is accepted that some mechanism exists that eats away at the rock, perhaps through specialized enzymes or compounds that ... and proteins. Other chemoheterotrophs include humans, mushrooms and lithotrophic bacteria. ... synthesize all necessary organic compounds from carbon dioxide. Chemoautotrophs use inorganic energy sources such as hydrogen ...
Fermentation only allows the breakdown of larger organic compounds, and produces small organic compounds. Methanogenesis ... These organisms may accomplish reverse methanogenesis using a nickel-containing protein similar to methyl-coenzyme M reductase ... During the decay process, electron acceptors (such as oxygen, ferric iron, sulfate, and nitrate) become depleted, while ... The carbon can occur in a small number of organic compounds, all with low molecular weights. The two best described pathways ...
Biomagnification of PCP in the food chain is not thought to be significant due to the fairly rapid metabolism of the compound ... PCP can be produced by the chlorination of phenol in the presence of catalyst (anhydrous aluminium or ferric chloride) and a ... Accumulation is not common, but if it does occur, the major sites are the liver, kidneys, plasma protein, spleen and fat. ... Pentachlorophenol (PCP) is an organochlorine compound used as a pesticide and a disinfectant. First produced in the 1930s, it ...
Decomposition is catalysed by various compounds, including most transition metals and their compounds (e.g. manganese dioxide, ... The toxicity is due to oxidation of proteins, membrane lipids and DNA by the peroxide ions.[33] The class of biological enzymes ... The net reaction of a ferric ion with hydrogen peroxide is a ferrous ion and oxygen. This proceeds via single electron ... This degrades organic compounds, including those that are ordinarily robust, such as aromatic or halogenated compounds.[55] It ...
Typically, ferric iron is removed from pyoverdine by reduction to the ferrous state, for which pyoverdine has a much lower (i.e ... The localization of some of the Pvd proteins in the periplasm and the outer membrane (such as PvdN, PvdO, PvdP, and PvdQ) have ... A compound related to pyoverdine, called pseudoverdine (formally known as 3-formylamino-6,7-dihydroxycoumarin) is also produced ... Exposure triggers a response that is consistent with hypoxia that depends on the HIF-1 protein, suggesting that the host ...
Wingfield, Paul T. (2017-05-05). "Protein Precipitation Using Ammonium Sulfate". Current protocols in protein science / ... The significance of this substance in the purification of compounds stems from its ability to become more so hydrated compared ... With trivalent metal ions, alums such as ferric ammonium sulfate are formed. Double metal sulfates include ammonium cobaltous ... enables protein separation based on a decrease in protein solubility; this separation may be achieved by centrifugation. ...
Human POR gene has 16 exons and the exons 2-16 code for a 677-amino acid POR protein (NCBI NP_000932.2). There is a single copy ... In yeast, POR affects the ferrireductase activity, probably transferring electrons to the flavocytochrome ferric reductase. ... Fifteen of nineteen patients having abnormal genitalia and disordered steroidogenesis were homozygous or apparent compound ... The FMN-binding domain is similar to the structure of FMN-containing protein flavodoxin, whereas the FAD-binding domain and ...
... forms compounds mainly in the oxidation states +2 (iron(II), "ferrous") and +3 (iron(III), "ferric"). Iron also occurs in ... Although the heme proteins are the most important class of iron-containing proteins, the iron-sulfur proteins are also very ... Iron forms compounds in a wide range of oxidation states, −2 to +7. Iron also forms many coordination compounds; some of them, ... The most commonly known and studied bioinorganic iron compounds (biological iron molecules) are the heme proteins: examples are ...
These genes encode proteins for iron storage, uptake of ferric-siderophores, and heme. Humans have evolved a defense for ... Barclay R, Ratledge C (Mar 1983). "Iron-binding compounds of Mycobacterium avium, M. intracellulare, M. scrofulaceum, and ... The lipocalin family of binding proteins are produced by the immune system and sequester ferric siderophore complexes from the ... In order to preserve homeostasis, organisms have evolved specific protein networks, with proteins and receptors translated in ...
In plants, VirA is a protein histidine kinase which senses certain sugars and phenolic compounds. These compounds are typically ... Results are typically expressed as gallic acid equivalents (GAE). Ferric chloride (FeCl3) test is also a colorimetric assay. ... Phenolic compounds, when used in beverages, such as prune juice, have been shown to be helpful in the color and sensory ... Such compounds can be implied in the hypersensitive response of plants. High levels of phenolics in some woods can explain ...
ferric iron binding. • metal ion binding. • protein binding. • ferric iron transmembrane transporter activity. • ferrous iron ... Reference ranges for blood tests, comparing blood content of transferrin and other iron-related compounds (shown in brown and ... "Transferrin is an insulin-like growth factor-binding protein-3 binding protein". The Journal of Clinical Endocrinology and ... regulation of protein stability. • transferrin transport. • iron ion homeostasis. • platelet degranulation. • ion transport. • ...
Ferric Compounds / pharmacology * Fluconazole / pharmacology * Fungal Proteins / genetics * Fungal Proteins / metabolism * Gene ... iron metabolism proteins, and drug resistance factors Antimicrob Agents Chemother. 2003 Jun;47(6):1805-17. doi: 10.1128/aac. ...
Ferric Compounds / metabolism* * Ferrichrome / analogs & derivatives * Ferrichrome / metabolism * Fungal Proteins / genetics* * ... The Sit1 protein is probably a permease specific for the transport of ferrioxamine-type siderophores. The evidence suggests ...
... and ASTRAL compendium for protein structure and sequence analysis ... Compound: ferric uptake regulation protein. Species: ... Compound: ferric uptake regulation protein. Species: HELICOBACTER PYLORI [TaxId:85962]. Database cross-references and ... Compound: ferric uptake regulation protein. Species: HELICOBACTER PYLORI [TaxId:85962]. Database cross-references and ... Compound: ferric uptake regulation protein. Species: HELICOBACTER PYLORI [TaxId:85962]. Database cross-references and ...
... phenolic compounds, proteins, cardenolides, starch grains, among other compounds, have already been identified in the latex of ... G, H. Phenolic compounds detected by toluidine blue (G) and ferric chloride (H). I. Polysaccharides identified with PAS ... G. Proteins in the latex identified with coomassie blue.. The function of such compounds is, either individually or ... D. Detection of phenolic compounds with ferric chloride. E. Mucilage identified using ruthenium red. F. Polysaccharides within ...
A common ferric compound is ferric chloride (FeCl3). In qualitative inorganic analysis, the presence of ferric ion can be ... The word ferric is derived from the Latin word ferrum for iron. Many proteins contain ferric ions. Examples include iron-sulfur ... In water, ferric iron forms compounds that are often insoluble, at least near neutral pH. A salt of ferric iron hydrolyzes ... Rust, a mixture of ferric hydroxide compounds, illustrates the low solubility of ferric ions in water. Various reagents cause ...
... and ASTRAL compendium for protein structure and sequence analysis ... Compound: Ferric vibriobactin ABC transporter, periplasmic ... Keywords: Iron-vibriobactin transport protein, Periplasmic transport protein, METAL TRANSPORT. Deposited on 2011-03-19, ... ferric vibriobactin-binding protein. Species: Vibrio cholerae [TaxId:666]. Gene: viuP, VC_0776. Database cross-references and ... SCOPe: Structural Classification of Proteins - extended. Release 2.07 (updated 2019-05-30, stable release March 2018) Copyright ...
Iron chemical compounds, which include ferrous and ferric compounds, have many uses. Iron oxide mixed with aluminium powder can ... compounds are common oxygen transport proteins in vertebrates. Iron is also the metal used at the active site of many important ... In all proteins, it is the amino acid sequence which determines the proteins chemical properties and function. There is more ... It forms binary compounds with the halogens and the chalcogens. Among its organometallic compounds is ferrocene, the first ...
Ferric oxide, saccharated. Ferric gluconate. Ferric Compounds. Trace Elements. Micronutrients. Growth Substances. Physiological ... Active Comparator: Ferric Gluconate Drug: sodium ferric gluconate complex in sucrose injection sodium ferric gluconate complex ... Comparison Between Effects of Two Iron Preparations on Protein in the Urine. The safety and scientific validity of this study ... Drug Information available for: Sucrose Sodium gluconate Manganese gluconate Iron, elemental Sodium ferric gluconate complex ...
Phenolic compounds and tannins are spotted by ferric chloride test and lead acetate test whereas tannins by the gelatin test [ ... Proteins and amino acids are distinguished by Millons reagent and Biurets test. Flavonoids are identified by alkaline reagent ... This cycle may be allowed to repeat many times so that the desired compound gets concentrated in the distillation flask [2, 16 ... U. Ozgen, M. Ikbal, A. Hacimuftuoglu et al., "Fibroblast growth stimulation by extracts and compounds of Onosma argentatum ...
Ferric Compounds Bacterial Outer Membrane Proteins Ion Channel Gating Siderophores Biological Models ... Transposable elements are found in a large number of human protein-coding genes. Nekrutenko, A. & Li, W. H., Nov 1 2001, In : ... Screw-cap clamp loader proteins that thread. Zhuang, Z., Spiering, M. M., Berdis, A. J., Trakselis, M. A. & Benkovic, S., Jul ... Chemoprevention of carcinogenesis by organoselenium compounds. Sugie, S., Tanaka, T. & El-Bayoumy, K., Jan 1 2000, In : Journal ...
Iron chemical compounds, which include ferrous and ferric compounds, have many uses. Iron oxide mixed with aluminium powder can ... these two compounds are common oxygen transport proteins in vertebrates. Iron is also the metal used at the active site of many ... Among its organometallic compounds is ferrocene, the first sandwich compound discovered.. Iron plays an important role in ... Read more about Iron: Chemistry and Compounds, Industrial Production, Biological Role, Precautions ...
... ferric chloride and compound tincture of benzoin. ... Note: Astringents act variously to cause protein precipitation ...
... ferric ammonium citrate, and iron-protein succinylate. Rapidly dissolving iron compounds have a solubility in water at 25 C. ... ferric ammonium tartrate, ferric phosphate, ferric potassium tartrate, ferric albuminate, ferric cacodylate, ferric hydroxide, ... soluble ferric pyrophosphate, ferric quinine citrate, ferric valerate, saccharated iron oxide, ferric chloride, ferrous iodide ... Examples of slowly dissolving iron compounds include ferric pyrophosphate and carbonyl iron. Slowly dissolving iron compounds ...
1977) Coordinate regulation by iron of the synthesis of phenolate compounds and three outer membrane proteins in Escherichia ... All the transport proteins bound ferric enterobactin with high affinity (Kd ≤ 100 nM) and transported it at comparable rates (≥ ... Among the compounds we tested, only ferric enantioenterobactin, the synthetic, left-handed isomer of natural enterobactin, and ... Siderophores (32) liberate iron from the sequestering proteins of eucaryotic hosts or solubilize it from precipitates of ferric ...
Siderophores, compounds of low molecular mass with high affinities for ferric iron, are important virulence factors in ... The HPI upon which the genes encoding the Ybt biosynthesis proteins are located is controlled by a series of molecular ... Because of its high affinity for iron, yersiniabactin can solubilize the metal bound to host binding proteins and transport it ... Miller, M. C.; Parkin, S.; Fetherston, J. D.; Perry, R. D.; Demoll, E. (2006). "Crystal structure of ferric-yersiniabactin, a ...
Amino acid- Organic compounds that form the building blocks of protein. There are 20 types of amino acids (eight are "essential ... after he added the chemical compound ferric chloride to it. Dr. Foiling expanded his study to other children whose urine had ... The body breaks down proteins from food into individual amino acids and then reassembles them into human proteins. Proteins are ... The body breaks down proteins from food into individual amino acids and then reassembles them into "human" proteins. Proteins ...
... that may play a role in TonB-dependent uptake of ferric iron compounds were found. There are three sets of exbBD genes in the W ... 31), GGDEF-family proteins (no. 28), transposases (no. 17), conserved hypothetical proteins (no. 20), and hypothetical proteins ... Protein Glycosylation. N-linked glycosylation is the most frequent protein-modification system in eukaryotes and can be found ... 2A). A total of 614 proteins was found to show highest homology between W. succinogenes and C. jejuni, whereas 655 proteins ...
... ferric chloride, amyl alcohol; Phenolic compounds and tannins with lead acetate and gelatin; carbohydrate with Molish s, ... Estimation of total protein: Total protein was estimated in brain homogenate by using suitable reagents method (Lowry et al., ... Effect of EEFH on protein level: In the present study the protein level of Aβ 25-35 induced group show significant (p,0.05) ... GSH protects cellular protein-thiols against irreversible loss, thus preserving protein function. ...
... ferric chloride, and amyl alcohol.(iii)Phenolic compounds and tannins with lead acetate and gelatin.(iv)Carbohydrate with ... Effect of EEMT on Total Protein in Aspirin + Pylorus Ligated Gastric Ulcer. The total protein (μg/mL) was significantly ... The protein content was calculated from standard curve prepared with bovine albumin and has been expressed in terms of μg/mL of ... EEMT at both dose levels showed significant reduction in dissolved protein content (. 𝑃. ,. 0. .. 0. 1. ) compared to control. ...
... ferric chloride, amyl alcohol; Phenolic compounds and tannins with lead acetate and gelatin; carbohydrate with Molishs, ... Fehlings and Benedicts reagent; proteins and amino acids with Millons,Biuret, and xanthoprotein test. Saponins was tested ...
... secreted compounds with a high affinity for ferric iron - and siderophore-binding proteins during bacterial infection of ... binding proteins, which deliver iron to ferritin and other iron-dependent proteins; and 3) Grx3-type monothiol glutaredoxins, ... including protein-protein interactions at the site of metal transfer, metal coordination configurations and slow transport ... Yvain Nicolet and Juan C. Fontecilla-Camps focus on the proteins responsible for active-site maturation of the metalloenzyme [ ...
... where the IroN outer membrane protein can recognize both ferric-siderophores (54). In contrast, E. coli FepA recognizes ferric ... Coordination chemistry of microbial iron transport compounds. 19. Stability constants and electrochemical behavior of ferric ... The Bacillus subtilis ferric uptake regulator (Fur) protein mediates the iron-dependent repression of at least 20 operons ... To prepare extracellular proteins, the proteins in the medium were precipitated with ice-cold 10% (wt/vol) trichloroacetic acid ...
... low molecular-mass ferric binding compounds, allow A. baumannii to acquire iron under iron-deficient environment (202). Recent ... Penicillin-binding protein 7/8 contributes to the survival of Acinetobacter baumannii in vitro and in vivo. J Infect Dis 2009; ... Outer membrane protein 38 of Acinetobacter baumannii localizes to the mitochondria and induces apoptosis of epithelial cells. ... One prominent virulence factor, outer membrane protein (OmpA) of 38 kDa, plays a role in the attachment to biotic and abiotic ...
Ferric Compounds. Myocardium. Plasma Protein Binding Capacity. Vinyl Compounds. About this Paper. ... Effects of formylation of vinyl side chains of heme on optical and ligand binding properties of horse heart ferric myoglobin. ... The peak positions as well as the line shapes of the absorption spectra of the ferric derivatives of three kinds of ... Absorption maxima in the Soret region of the acid forms of these ferric formylmyoglobins in 0.1 M potassium phosphate buffer, ...
... group and are the subunites that polymerize to form proteins. "Salts" are the neutral compounds formed by the union of an acid ... minerals and trace metals such as ferrous and ferric compounds (e.g., nitrates and sulfates), complex sources of carbon and ... ECM proteins include, but are not limited to, fibrous proteins, adhesion proteins, glucosamineglycans and proteoglycans, and ... "VEGF" is a protein that stimulates the growth of new blood vessels. "EGF" is a protein that stimulates epidermal cells to ...
  • The importance of phenolic compounds on wine quality require methods that accurately measure the tannin content. (wineland.co.za)
  • Tannins are phenolic compounds that play an important role in the astringency perception of red wines. (wineland.co.za)
  • Tannins are phenolic compounds that are involved in red wine mouthfeel attributes. (wineland.co.za)
  • The antioxidant capacity of extract was well correlated with its TPC and TFC and this in turn was in keeping with the UPLC analysis which also revealed the presence of phenolic compounds that were responsible for the antioxidant and cytotoxic potential of S. cellulosae strain TES17. (biomedcentral.com)
  • R. Repo-Carrasco-Valencia, J. K. Hellstr?m, J.-M. Pihlava and P. H. Mattila, "Flavonoids and Other Phenolic Compounds in Andean Indigenous Grains: Quinoa (Chenopodium quinoa), Ka?iwa (Chenopodium pallidicaule) and Iwicha (Amaranthus caudatus)," Food Chemistry, Vol. 120, 2010, pp. 128-133. (scirp.org)
  • Common processing procedures, such as cooking and baking, decrease the levels of these bioactive compounds and consequently, overall antioxidant activity. (scirp.org)
  • Pathogenic and commensal bacteria alike obtain iron from human and animal hosts by competing for the metal with eucaryotic proteins, like transferrin, lactoferrin, and ferritin ( 11 , 25 , 49 , 54 ). (asm.org)
  • In contrast to other host-adapted bacteria, W. succinogenes does harbor the highest density of bacterial sensor kinases found in any bacterial genome to date, together with an elaborate signaling circuitry of the GGDEF family of proteins. (pnas.org)
  • In the final review, " Copper homeostasis at the host-pathogen interface ," Victoria Hodgkinson and Michael J. Petris cover three processes by which bacteria resist high copper levels as a result of host defense - removal of copper out of the cytoplasm, capture of copper via copper binding proteins and reduction of copper toxicity by oxidation of Cu(I) to Cu(II). (asbmb.org)
  • In many bacteria, the ferric uptake regulator (Fur) protein coordinates the expression of iron uptake and homeostasis pathways in response to available iron ( 1 ). (asm.org)
  • The Fur proteins of Vibrio anguillarum , Vibrio cholerae , and Vibrio vulnificus are very highly related, although they share only about 60% of their polynucleotide sequence with that of E. coli , while the Fur protein of Yersinia pestis is highly similar to Fur from E. coli and other enteric bacteria ( 25 , 26 , 83 , 117 , 132 ). (asm.org)
  • Siderophore-interacting proteins (SIPs), such as YqjH from Escherichia coli, are widespread among bacteria and commonly associated with iron-dependent induction and siderophore utilization. (nih.gov)
  • Transport-related proteins of bacteria are important in allowing the uptake of essential nutrients or ions, and extrusion of metabolic end products and hazardous substances. (biomedcentral.com)
  • Bacteria employ different mechanisms for transport of different chemicals and these mechanisms have been classified into seven major categories according to the Transport Protein Database (TCDB): channels and pores (class 1), electrochemical potential-driven transporters (class 2), primary active transporters (class 3), group translocators (class 4), transmembrane electron carriers (class 5), accessory factors involved in transport (class 8), and incompletely characterized transport systems (class 9). (biomedcentral.com)
  • The insertion and assembly of proteins into the inner membrane of bacteria are crucial for many cellular processes, including cellular respiration, signal transduction, and ion and pH homeostasis. (asmscience.org)
  • In addition, we will review the mechanism by which a variety of proteins with different topologies are inserted into the inner membrane of Gram-negative bacteria. (asmscience.org)
  • Some traditional remedies have already produced compounds that are effective against antibiotic-resistant strains of bacteria 6 . (ijpsr.com)
  • A siderophore of this apparent structure was first described as a product of Corynebacterium glutamicum and named corynebactin ( 12 ), but recent genome sequence and biochemical analyses suggest that this organism is unlikely to produce this compound ( 16 ). (asm.org)
  • Despite these regulatory differences the mechanisms of siderophore biosynthesis follow the same fundamental enzymatic logic, which involves a series of elongating acyl-S-enzyme intermediates on multimodular protein assembly lines: nonribosomal peptide synthetases (NRPS). (asm.org)
  • AngR, a 110-kDa protein component of this system, appears to play a role in both regulation of the expression of the iron transport genes fatDCBA and the production of the siderophore anguibactin. (asm.org)
  • Further, combination of a chromosomal yqjH deletion with entC single- and entC fes double-deletion backgrounds showed the impact of yqjH on growth during supplementation with ferric siderophore substrates. (nih.gov)
  • Thus, YqjH enhances siderophore utilization in different iron acquisition pathways, including assimilation of low-potential ferric substrates that are not reduced by common cellular cofactors. (nih.gov)
  • CB activates the salicylic acid (SA)-mediated signaling pathway, while the CB ferric complex is ineffective, suggesting that the elicitor activity of this siderophore is due to its iron-binding property. (plantphysiol.org)
  • L. hongkongensis is unique among closely related members of Neisseriaceae family in possessing higher number of proteins related to transport of ammonium, urea and dicarboxylate, which may reflect the importance of nitrogen and dicarboxylate metabolism in this assacharolytic bacterium. (biomedcentral.com)
  • The high variability of the surface proteins of influenza virus, hemagglutinin and neuraminidase, requires strain-specific vaccines matching the antigenic specificity of newly emerging virus strains to be developed. (chemweb.com)
  • It is a stypic or hemostatic agent that causes agglutination of surface proteins resulting in local hemostasis. (shreejiexports.net)
  • Starting with the assumptions that tannins polymerise during ageing and that the ability of the tannins to elicit astringency increases with tannin size (i.e. the bigger the molecule, and the higher the number of sites available to interact with the salivary proteins, the higher the ability to combine and precipitate proteins) 2 other phenomena that explains the decrease in the astringency intensity needs also to be playing role. (wineland.co.za)
  • The experiments refuted the idea that chirality of the iron complex affects its recognition by FepA and demonstrated the necessity of an unsubstituted catecholate coordination center for binding to the outer membrane protein. (asm.org)
  • However, the FepA and IroN proteins of S. typhimurium failed to efficiently function in E. coli . (asm.org)
  • The anthocyanin-tannin molecules cause a reduction on the ability of the newly formed polymeric pigment to interact with salivary protein thus reducing astringency (phenomenon that could also be related to the abovementioned conformation rearrangement scenario). (wineland.co.za)
  • Reduction of ferric iron to ferrous iron by enzymatic or nonenzymatic means is a common mechanism among pathogenic yeasts. (asm.org)
  • The reduction of organic compounds attributable to biodegradation occurred in the upper layer of the biofilter as confirmed by the highest consumption of dissolved oxygen and biomass concentrations at that location. (uwaterloo.ca)
  • The observed reduction in TMP was attributed to the removal of biopolymers (especially the protein component) and turbidity through biofiltration. (uwaterloo.ca)
  • 1 H-NMR studies have evidenced the stabilization of a G-quadruplex by the perylenetetracarboxylic acid diimide compounds and provided evidence that these and structurally related compounds inhibit the telomerase enzyme by a mechanism consistent with interaction with G-quadruplex structures. (google.com)
  • Ceruloplasmin, a copper-containing plasma enzyme, catalyses the oxidation of the ferrous ion to ferric ion, and thereby enables iron to be trapped by transferrin (a protein transporting iron in the blood). (vitaminsdiary.com)
  • Nucleases and methods of using these nucleases for inserting a sequence encoding a therapeutic protein such as an enzyme into a cell, thereby providing. (patents.com)
  • For many years Mühlenchemie has developed enzyme compounds for the pasta industry. (world-grain.com)
  • With an enzyme compound from the Pastazym Plus series, Mühlenchemie succeeded in producing spaghetti that had attributes identical to those of the 100% durum model in respect of color, bite and cooking properties. (world-grain.com)
  • The effects of DES on the anti-oxidant system, non-protein sulfhydryl (NP-SH) content, nitric oxide (NO)level, cyclooxygenase-2 (COX-2) enzyme activity, bcl-2-associated X (Bax) protein expression and Helicabacter pylori ( H pylori ) were also investigated. (biomedcentral.com)
  • In the enzymatic cycle of this family of oxidative metabolizing heme proteins, hydrogen peroxide is required to transform the ferric resting state to the catalytically active, ferryl FeO, compound I species. (rti.org)
  • Ammonium phosphate (monobasic) is another compound contained in Miracle Gro that provides the macronutrients nitrogen and phosphorous. (gardenguides.com)
  • Biomineralization proteins are widely used as templating agents in biomimetic synthesis of a variety of organic-inorganic nanostructures. (nih.gov)
  • It is required for the catalytic activity of proteins mediating electron transfer and redox reactions, such as those involved in respiration, photosynthesis, DNA synthesis, and defense against reactive oxygen species. (plantphysiol.org)
  • This book contains the constitution and synthesis of the Amino Acids, the Isolation of the Amino Acids from Proteins, the preparation of Amino Acids and Proteins, Vitamins and Fine Chemicals with Method of analysis and reactions etc. (niir.org)
  • It is then transported to tissues for the synthesis of iron-containing compounds, especially haemoglobin. (vitaminsdiary.com)
  • The globin is converted to amino acids for the synthesis of other proteins. (tabers.com)
  • In qualitative inorganic analysis, the presence of ferric ion can be detected by the formation of its thiocyanate complex. (wikipedia.org)
  • When triiodide bound to ARP, unlike the rearrangement of the distal arginine of cytochrome c peroxidase that occurs on formation of the fluoride complex or compound I, the side chain of Arg-52 moved little. (rcsb.org)
  • Conformational flexibility of His-56 appears to be a requisite for proton translocation from one oxygen atom to the other of HOO- by acid-base catalysis to produce compound I. The iron atom in each cyanide complex (low-spin ferric) is located in the heme plane, whereas in each triiodide complex (high-spin ferric) the iron atom is displaced from the plane about 0.2 A toward the proximal side. (rcsb.org)
  • Fluorescence quenching experiments yielded values for the stoichiometry and apparent dissociation constant of the ferric ion-glycine-extended gastrin(17) complex at pH 4.0 of 2.39 +/- 0.17 mol of Fe(3+)/mol and 0.62 +/- 0.19 microM, respectively. (austin.org.au)
  • Uranium exposures in these populations is to a complex mixture of radon gas and daughter isotopes as well as to airborne dusts containing a variety of uranium compounds including various water insoluble uranium oxides. (cdc.gov)
  • A coordination compound (or coordination complex) consists of a metal cation or neutral atom to which neutral or negatively charged ligands have bonded. (ukessays.com)
  • When drinking red wine, the tannin compounds interact with the salivary proteins, creating a macromolecular complex that precipitates from solution and causes a drying and puckering mouthfeel sensation, also known as astringency. (wineland.co.za)
  • A module of a PPI network may represent a protein complex, or a group of proteins participating in the same cellular process. (biomedcentral.com)
  • The invention relates to iron(III) complex compounds and pharmaceutical compositions comprising them for the use as medicaments, in particular for the treatment and/or prophylaxis of iron deficiency symptoms and iron deficiency anemias. (patents.com)
  • The catabolism of the methyl compounds is mediated by methyl transferases to give methyl coenzyme M. The biochemistry of methanogenesis is relatively complex, involving the following coenzymes and cofactors: F420, coenzyme B, coenzyme M, methanofuran, and methanopterin. (wikipedia.org)
  • The peak positions as well as the line shapes of the absorption spectra of the ferric derivatives of three kinds of formylmyoglobin, 2-vinyl-4-formyl-, 2-formyl-4-vinyl-, and 2,4-diformylmyoglobins depend on the number and the position of the formyl groups. (meta.org)
  • Absorption maxima in the Soret region of the acid forms of these ferric formylmyoglobins in 0.1 M potassium phosphate buffer, pH 6.0, at 20 degrees were 415.2, 422, and 429 nm, respectively. (meta.org)
  • In the parallel published human study from the Nestlé Research Center in Lausanne and ETH in Zurich, it has been shown that the iron absorption from the fortified bouillon with the hydrolysed corn protein compound was twice the rate compared to ferric pyrophosphate, which is often used today for iron fortification of foods outside Europe. (medicalxpress.com)
  • When the new compound was tested in foods containing iron absorption inhibitors, such as corn porridge, the absorption was five times as high compared to ferric pyrophosphate. (medicalxpress.com)
  • On the basis of studies in animals, absorption of more water soluble uranyl compounds is greater than less soluble oxides and tetrahalide compounds. (cdc.gov)
  • Considered a macronutrient, potassium helps in water absorption and loss, cell division, and the processing of sugars, starches, and proteins in plants. (gardenguides.com)
  • The magnetism of ferric compounds is mainly determined by these five electrons, and their behavior depends on the number and type of ligands attached to iron, as described by ligand field theory. (wikipedia.org)
  • Some ligands can donate two pairs of electrons and are termed bidentate, for example, H2N-CH2-CH2-NH2 (ethylenediamine or en), and O2C-CO22âˆ' (oxalate anion or ox). (ukessays.com)
  • Many foods contain soluble iron compounds and are therefore necessary for good nutrition. (wikipedia.org)
  • The hybrid protein M2eHBc was synthesized in the infected N. benthamiana plants in an amount reaching 1-2% of the total soluble protein and formed virus-like particles with the M2e peptide presented on the surface. (chemweb.com)
  • In its ferrous form, iron is more soluble and catalyzes the Fenton reaction in the presence of hydrogen peroxide, which leads to the formation of hydroxyl radicals, resulting in protein denaturation, DNA breaks, and lipid peroxidation ( Pierre and Fontecave, 1999 ). (plantphysiol.org)
  • Structural data have revealed a common active site motif for the binding of the substrate carboxylate group in the peroxygenases, and mechanistic and transient kinetic analyses have demonstrated the formation of reactive iron-oxo species (compounds I and II) that are ultimately responsible for hydroxylation and decarboxylation of fatty acids, respectively. (biochemsoctrans.org)
  • Ferric Glycerophosphate is used as base coating for paint in order to increase adhesion to the iron or steel substrate. (shreejiexports.net)
  • The current study reveals that DES demonstrated gastroprotective effects which could be attributed to its antioxidant effect, activation of HSP-70 protein, intervention with COX-2 inflammatory pathway and potent anti H pylori effect. (biomedcentral.com)