Molecular Sequence Data
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Amino Acid Sequence
Protein Phosphatase 2
A phosphoprotein phosphatase subtype that is comprised of a catalytic subunit and two different regulatory subunits. At least two genes encode isoforms of the protein phosphatase catalytic subunit, while several isoforms of regulatory subunits exist due to the presence of multiple genes and the alternative splicing of their mRNAs. Protein phosphatase 2 acts on a broad variety of cellular proteins and may play a role as a regulator of intracellular signaling processes.
Casein Kinase II
Calcium-Calmodulin-Dependent Protein Kinases
A CALMODULIN-dependent enzyme that catalyzes the phosphorylation of proteins. This enzyme is also sometimes dependent on CALCIUM. A wide range of proteins can act as acceptor, including VIMENTIN; SYNAPSINS; GLYCOGEN SYNTHASE; MYOSIN LIGHT CHAINS; and the MICROTUBULE-ASSOCIATED PROTEINS. (From Enzyme Nomenclature, 1992, p277)
Protein Phosphatase 1
A eukayrotic protein serine-threonine phosphatase subtype that dephosphorylates a wide variety of cellular proteins. The enzyme is comprised of a catalytic subunit and regulatory subunit. Several isoforms of the protein phosphatase catalytic subunit exist due to the presence of multiple genes and the alternative splicing of their mRNAs. A large number of proteins have been shown to act as regulatory subunits for this enzyme. Many of the regulatory subunits have additional cellular functions.
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
Sequence Homology, Amino Acid
Protein Kinase C
An serine-threonine protein kinase that requires the presence of physiological concentrations of CALCIUM and membrane PHOSPHOLIPIDS. The additional presence of DIACYLGLYCEROLS markedly increases its sensitivity to both calcium and phospholipids. The sensitivity of the enzyme can also be increased by PHORBOL ESTERS and it is believed that protein kinase C is the receptor protein of tumor-promoting phorbol esters.
Proto-Oncogene Proteins c-pim-1
Phosphotransferases that catalyzes the conversion of 1-phosphatidylinositol to 1-phosphatidylinositol 3-phosphate. Many members of this enzyme class are involved in RECEPTOR MEDIATED SIGNAL TRANSDUCTION and regulation of vesicular transport with the cell. Phosphatidylinositol 3-Kinases have been classified both according to their substrate specificity and their mode of action within the cell.
Proto-Oncogene Proteins c-akt
MAP Kinase Signaling System
An intracellular signaling system involving the MAP kinase cascades (three-membered protein kinase cascades). Various upstream activators, which act in response to extracellular stimuli, trigger the cascades by activating the first member of a cascade, MAP KINASE KINASE KINASES; (MAPKKKs). Activated MAPKKKs phosphorylate MITOGEN-ACTIVATED PROTEIN KINASE KINASES which in turn phosphorylate the MITOGEN-ACTIVATED PROTEIN KINASES; (MAPKs). The MAPKs then act on various downstream targets to affect gene expression. In mammals, there are several distinct MAP kinase pathways including the ERK (extracellular signal-regulated kinase) pathway, the SAPK/JNK (stress-activated protein kinase/c-jun kinase) pathway, and the p38 kinase pathway. There is some sharing of components among the pathways depending on which stimulus originates activation of the cascade.
Glycogen Synthase Kinase 3
Tumor Cells, Cultured
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
Death-Associated Protein Kinases
MAP Kinase Kinase Kinases
Proto-Oncogene Proteins c-raf
A family of highly conserved serine-threonine kinases that are involved in the regulation of MITOSIS. They are involved in many aspects of cell division, including centrosome duplication, SPINDLE APPARATUS formation, chromosome alignment, attachment to the spindle, checkpoint activation, and CYTOKINESIS.
Receptors for ACTIVINS are membrane protein kinases belonging to the family of PROTEIN-SERINE-THREONINE KINASES, thus also named activin receptor-like kinases (ALK's). Activin receptors also bind TRANSFORMING GROWTH FACTOR BETA. As those transmembrane receptors of the TGF-beta superfamily (RECEPTORS, TRANSFORMING GROWTH FACTOR BETA), ALK's consist of two different but related protein kinases, Type I and Type II. Activins initiate cellular signal transduction by first binding to the type II receptors (ACTIVIN RECEPTORS, TYPE II ) which then recruit and phosphorylate the type I receptors (ACTIVIN RECEPTORS, TYPE I ) with subsequent activation of the type I kinase activity.
Cyclic AMP-Dependent Protein Kinases
Aurora Kinase A
A PROTEIN-TYROSINE KINASE family that was originally identified by homology to the Rous sarcoma virus ONCOGENE PROTEIN PP60(V-SRC). They interact with a variety of cell-surface receptors and participate in intracellular signal transduction pathways. Oncogenic forms of src-family kinases can occur through altered regulation or expression of the endogenous protein and by virally encoded src (v-src) genes.
Receptors, Transforming Growth Factor beta
Cell-surface proteins that bind transforming growth factor beta and trigger changes influencing the behavior of cells. Two types of transforming growth factor receptors have been recognized. They differ in affinity for different members of the transforming growth factor beta family and in cellular mechanisms of action.
A pyridoxal-phosphate protein that catalyzes the deamination of THREONINE to 2-ketobutyrate and AMMONIA. The role of this enzyme can be biosynthetic or biodegradative. In the former role it supplies 2-ketobutyrate required for ISOLEUCINE biosynthesis, while in the latter it is only involved in the breakdown of threonine to supply energy. This enzyme was formerly listed as EC 220.127.116.11.
Ribosomal Protein S6 Kinases
A family of protein serine/threonine kinases which act as intracellular signalling intermediates. Ribosomal protein S6 kinases are activated through phosphorylation in response to a variety of HORMONES and INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS. Phosphorylation of RIBOSOMAL PROTEIN S6 by enzymes in this class results in increased expression of 5' top MRNAs. Although specific for RIBOSOMAL PROTEIN S6 members of this class of kinases can act on a number of substrates within the cell. The immunosuppressant SIROLIMUS inhibits the activation of ribosomal protein S6 kinases.
Protein Structure, Tertiary
The level of protein structure in which combinations of secondary protein structures (alpha helices, beta sheets, loop regions, and motifs) pack together to form folded shapes called domains. Disulfide bridges between cysteines in two different parts of the polypeptide chain along with other interactions between the chains play a role in the formation and stabilization of tertiary structure. Small proteins usually consist of only one domain but larger proteins may contain a number of domains connected by segments of polypeptide chain which lack regular secondary structure.
Mitogen-Activated Protein Kinase Kinases
A serine-threonine protein kinase family whose members are components in protein kinase cascades activated by diverse stimuli. These MAPK kinases phosphorylate MITOGEN-ACTIVATED PROTEIN KINASES and are themselves phosphorylated by MAP KINASE KINASE KINASES. JNK kinases (also known as SAPK kinases) are a subfamily.
Recombinant Fusion Proteins
Mitogen-Activated Protein Kinase 1
p38 Mitogen-Activated Protein Kinases
A mitogen-activated protein kinase subfamily that regulates a variety of cellular processes including CELL GROWTH PROCESSES; CELL DIFFERENTIATION; APOPTOSIS; and cellular responses to INFLAMMATION. The P38 MAP kinases are regulated by CYTOKINE RECEPTORS and can be activated in response to bacterial pathogens.
Cell lines whose original growing procedure consisted being transferred (T) every 3 days and plated at 300,000 cells per plate (J Cell Biol 17:299-313, 1963). Lines have been developed using several different strains of mice. Tissues are usually fibroblasts derived from mouse embryos but other types and sources have been developed as well. The 3T3 lines are valuable in vitro host systems for oncogenic virus transformation studies, since 3T3 cells possess a high sensitivity to CONTACT INHIBITION.
Mitogen-Activated Protein Kinases
A superfamily of PROTEIN-SERINE-THREONINE KINASES that are activated by diverse stimuli via protein kinase cascades. They are the final components of the cascades, activated by phosphorylation by MITOGEN-ACTIVATED PROTEIN KINASE KINASES, which in turn are activated by mitogen-activated protein kinase kinase kinases (MAP KINASE KINASE KINASES).
Intracellular Signaling Peptides and Proteins
Proteins and peptides that are involved in SIGNAL TRANSDUCTION within the cell. Included here are peptides and proteins that regulate the activity of TRANSCRIPTION FACTORS and cellular processes in response to signals from CELL SURFACE RECEPTORS. Intracellular signaling peptide and proteins may be part of an enzymatic signaling cascade or act through binding to and modifying the action of other signaling factors.
One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.
Within a eukaryotic cell, a membrane-limited body which contains chromosomes and one or more nucleoli (CELL NUCLEOLUS). The nuclear membrane consists of a double unit-type membrane which is perforated by a number of pores; the outermost membrane is continuous with the ENDOPLASMIC RETICULUM. A cell may contain more than one nucleus. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)
Aurora Kinase C
JNK Mitogen-Activated Protein Kinases
CDC2 Protein Kinase
Phosphoprotein with protein kinase activity that functions in the G2/M phase transition of the CELL CYCLE. It is the catalytic subunit of the MATURATION-PROMOTING FACTOR and complexes with both CYCLIN A and CYCLIN B in mammalian cells. The maximal activity of cyclin-dependent kinase 1 is achieved when it is fully dephosphorylated.
CELL LINES derived from the CV-1 cell line by transformation with a replication origin defective mutant of SV40 VIRUS, which codes for wild type large T antigen (ANTIGENS, POLYOMAVIRUS TRANSFORMING). They are used for transfection and cloning. (The CV-1 cell line was derived from the kidney of an adult male African green monkey (CERCOPITHECUS AETHIOPS).)
A group of intracellular-signaling serine threonine kinases that bind to RHO GTP-BINDING PROTEINS. They were originally found to mediate the effects of rhoA GTP-BINDING PROTEIN on the formation of STRESS FIBERS and FOCAL ADHESIONS. Rho-associated kinases have specificity for a variety of substrates including MYOSIN-LIGHT-CHAIN PHOSPHATASE and LIM KINASES.
Cyclin-Dependent Kinase 5
Mitogen-Activated Protein Kinase 3
A group of protein-serine-threonine kinases that was originally identified as being responsible for the PHOSPHORYLATION of CASEINS. They are ubiquitous enzymes that have a preference for acidic proteins. Casein kinases play a role in SIGNAL TRANSDUCTION by phosphorylating a variety of regulatory cytoplasmic and regulatory nuclear proteins.
TOR Serine-Threonine Kinases
A serine threonine kinase that controls a wide range of growth-related cellular processes. The protein is referred to as the target of RAPAMYCIN due to the discovery that SIROLIMUS (commonly known as rapamycin) forms an inhibitory complex with TACROLIMUS BINDING PROTEIN 1A that blocks the action of its enzymatic activity.
Gene Expression Regulation, Enzymologic
MAP Kinase Kinase 1
Cell Cycle Proteins
Proteins that control the CELL DIVISION CYCLE. This family of proteins includes a wide variety of classes, including CYCLIN-DEPENDENT KINASES, mitogen-activated kinases, CYCLINS, and PHOSPHOPROTEIN PHOSPHATASES as well as their putative substrates such as chromatin-associated proteins, CYTOSKELETAL PROTEINS, and TRANSCRIPTION FACTORS.
Activin Receptors, Type I
The arrangement of two or more amino acid or base sequences from an organism or organisms in such a way as to align areas of the sequences sharing common properties. The degree of relatedness or homology between the sequences is predicted computationally or statistically based on weights assigned to the elements aligned between the sequences. This in turn can serve as a potential indicator of the genetic relatedness between the organisms.
3-Phosphoinositide-Dependent Protein Kinases
Analysis of PEPTIDES that are generated from the digestion or fragmentation of a protein or mixture of PROTEINS, by ELECTROPHORESIS; CHROMATOGRAPHY; or MASS SPECTROMETRY. The resulting peptide fingerprints are analyzed for a variety of purposes including the identification of the proteins in a sample, GENETIC POLYMORPHISMS, patterns of gene expression, and patterns diagnostic for diseases.
Receptors, Growth Factor
Adaptor Proteins, Signal Transducing
A broad category of carrier proteins that play a role in SIGNAL TRANSDUCTION. They generally contain several modular domains, each of which having its own binding activity, and act by forming complexes with other intracellular-signaling molecules. Signal-transducing adaptor proteins lack enzyme activity, however their activity can be modulated by other signal-transducing enzymes
Receptor Protein-Tyrosine Kinases
A dsRNA-activated cAMP-independent protein serine/threonine kinase that is induced by interferon. In the presence of dsRNA and ATP, the kinase autophosphorylates on several serine and threonine residues. The phosphorylated enzyme catalyzes the phosphorylation of the alpha subunit of EUKARYOTIC INITIATION FACTOR-2, leading to the inhibition of protein synthesis.
Protein Kinase C-alpha
Ribosomal Protein S6 Kinases, 90-kDa
A family of ribosomal protein S6 kinases that are structurally distinguished from RIBOSOMAL PROTEIN S6 KINASES, 70-KDA by their apparent molecular size and the fact they contain two functional kinase domains. Although considered RIBOSOMAL PROTEIN S6 KINASES, members of this family are activated via the MAP KINASE SIGNALING SYSTEM and have been shown to act on a diverse array of substrates that are involved in cellular regulation such as RIBOSOMAL PROTEIN S6 and CAMP RESPONSE ELEMENT-BINDING PROTEIN.
Extracellular Signal-Regulated MAP Kinases
A mitogen-activated protein kinase subfamily that is widely expressed and plays a role in regulation of MEIOSIS; MITOSIS; and post mitotic functions in differentiated cells. The extracellular signal regulated MAP kinases are regulated by a broad variety of CELL SURFACE RECEPTORS and can be activated by certain CARCINOGENS.
Two-Hybrid System Techniques
Screening techniques first developed in yeast to identify genes encoding interacting proteins. Variations are used to evaluate interplay between proteins and other molecules. Two-hybrid techniques refer to analysis for protein-protein interactions, one-hybrid for DNA-protein interactions, three-hybrid interactions for RNA-protein interactions or ligand-based interactions. Reverse n-hybrid techniques refer to analysis for mutations or other small molecules that dissociate known interactions.
The complex series of phenomena, occurring between the end of one CELL DIVISION and the end of the next, by which cellular material is duplicated and then divided between two daughter cells. The cell cycle includes INTERPHASE, which includes G0 PHASE; G1 PHASE; S PHASE; and G2 PHASE, and CELL DIVISION PHASE.
Protein Processing, Post-Translational
Any of various enzymatically catalyzed post-translational modifications of PEPTIDES or PROTEINS in the cell of origin. These modifications include carboxylation; HYDROXYLATION; ACETYLATION; PHOSPHORYLATION; METHYLATION; GLYCOSYLATION; ubiquitination; oxidation; proteolysis; and crosslinking and result in changes in molecular weight and electrophoretic motility.
Linear POLYPEPTIDES that are synthesized on RIBOSOMES and may be further modified, crosslinked, cleaved, or assembled into complex proteins with several subunits. The specific sequence of AMINO ACIDS determines the shape the polypeptide will take, during PROTEIN FOLDING, and the function of the protein.
MAP Kinase Kinase 4
Protein Kinase C-delta
Transforming Growth Factor beta
A factor synthesized in a wide variety of tissues. It acts synergistically with TGF-alpha in inducing phenotypic transformation and can also act as a negative autocrine growth factor. TGF-beta has a potential role in embryonal development, cellular differentiation, hormone secretion, and immune function. TGF-beta is found mostly as homodimer forms of separate gene products TGF-beta1, TGF-beta2 or TGF-beta3. Heterodimers composed of TGF-beta1 and 2 (TGF-beta1.2) or of TGF-beta2 and 3 (TGF-beta2.3) have been isolated. The TGF-beta proteins are synthesized as precursor proteins.
Gene Expression Regulation
RNA, Small Interfering
Small double-stranded, non-protein coding RNAs (21-31 nucleotides) involved in GENE SILENCING functions, especially RNA INTERFERENCE (RNAi). Endogenously, siRNAs are generated from dsRNAs (RNA, DOUBLE-STRANDED) by the same ribonuclease, Dicer, that generates miRNAs (MICRORNAS). The perfect match of the siRNAs' antisense strand to their target RNAs mediates RNAi by siRNA-guided RNA cleavage. siRNAs fall into different classes including trans-acting siRNA (tasiRNA), repeat-associated RNA (rasiRNA), small-scan RNA (scnRNA), and Piwi protein-interacting RNA (piRNA) and have different specific gene silencing functions.
Phosphotransferases (Alcohol Group Acceptor)
I-kappa B Kinase
Protein Kinase C beta
PKC beta encodes two proteins (PKCB1 and PKCBII) generated by alternative splicing of C-terminal exons. It is widely distributed with wide-ranging roles in processes such as B-cell receptor regulation, oxidative stress-induced apoptosis, androgen receptor-dependent transcriptional regulation, insulin signaling, and endothelial cell proliferation.
AMP-Activated Protein Kinases
Intracellular signaling protein kinases that play a signaling role in the regulation of cellular energy metabolism. Their activity largely depends upon the concentration of cellular AMP which is increased under conditions of low energy or metabolic stress. AMP-activated protein kinases modify enzymes involved in LIPID METABOLISM, which in turn provide substrates needed to convert AMP into ATP.
Ribosomal Protein S6 Kinases, 70-kDa
A family of ribosomal protein S6 kinases that are considered the major physiological kinases for RIBOSOMAL PROTEIN S6. Unlike RIBOSOMAL PROTEIN S6 KINASES, 90KDa the proteins in this family are sensitive to the inhibitory effects of RAPAMYCIN and contain a single kinase domain. They are referred to as 70kDa proteins, however ALTERNATIVE SPLICING of mRNAs for proteins in this class also results in 85kDa variants being formed.
Electrophoresis, Polyacrylamide Gel
Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.
Protein Kinase C-epsilon
A protein kinase C subtype that was originally characterized as a CALCIUM-independent, serine-threonine kinase that is activated by PHORBOL ESTERS and DIACYLGLYCEROLS. It is targeted to specific cellular compartments in response to extracellular signals that activate G-PROTEIN-COUPLED RECEPTORS; TYROSINE KINASE RECEPTORS; and intracellular protein tyrosine kinase.
Oncogene Proteins v-raf
Amino Acid Motifs
A transferase that catalyzes formation of PHOSPHOCREATINE from ATP + CREATINE. The reaction stores ATP energy as phosphocreatine. Three cytoplasmic ISOENZYMES have been identified in human tissues: the MM type from SKELETAL MUSCLE, the MB type from myocardial tissue and the BB type from nervous tissue as well as a mitochondrial isoenzyme. Macro-creatine kinase refers to creatine kinase complexed with other serum proteins.
A large family of signal-transducing adaptor proteins present in wide variety of eukaryotes. They are PHOSPHOSERINE and PHOSPHOTHREONINE binding proteins involved in important cellular processes including SIGNAL TRANSDUCTION; CELL CYCLE control; APOPTOSIS; and cellular stress responses. 14-3-3 proteins function by interacting with other signal-transducing proteins and effecting changes in their enzymatic activity and subcellular localization. The name 14-3-3 derives from numerical designations used in the original fractionation patterns of the proteins.
Glycogen Synthase Kinases
A class of protein-serine-threonine kinases that was originally found as one of the three types of kinases that phosphorylate GLYCOGEN SYNTHASE. Glycogen synthase kinases along with CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASES and CYCLIC AMP-DEPENDENT PROTEIN KINASES regulate glycogen synthase activity.
NIH 3T3 Cells
A continuous cell line of high contact-inhibition established from NIH Swiss mouse embryo cultures. The cells are useful for DNA transfection and transformation studies. (From ATCC [Internet]. Virginia: American Type Culture Collection; c2002 [cited 2002 Sept 26]. Available from http://www.atcc.org/)
Dose-Response Relationship, Drug
A gene silencing phenomenon whereby specific dsRNAs (RNA, DOUBLE-STRANDED) trigger the degradation of homologous mRNA (RNA, MESSENGER). The specific dsRNAs are processed into SMALL INTERFERING RNA (siRNA) which serves as a guide for cleavage of the homologous mRNA in the RNA-INDUCED SILENCING COMPLEX. DNA METHYLATION may also be triggered during this process.
Bone Morphogenetic Protein Receptors, Type I
Amino Acid Substitution
The naturally occurring or experimentally induced replacement of one or more AMINO ACIDS in a protein with another. If a functionally equivalent amino acid is substituted, the protein may retain wild-type activity. Substitution may also diminish, enhance, or eliminate protein function. Experimentally induced substitution is often used to study enzyme activities and binding site properties.
Cell Transformation, Neoplastic
Aurora Kinase B
Calcium-Calmodulin-Dependent Protein Kinase Type 2
A multifunctional calcium-calmodulin-dependent protein kinase subtype that occurs as an oligomeric protein comprised of twelve subunits. It differs from other enzyme subtypes in that it lacks a phosphorylatable activation domain that can respond to CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASE KINASE.
MAP Kinase Kinase Kinase 1
Reverse Transcriptase Polymerase Chain Reaction
Bone Morphogenetic Protein Receptors
A deoxyribonucleotide polymer that is the primary genetic material of all cells. Eukaryotic and prokaryotic organisms normally contain DNA in a double-stranded state, yet several important biological processes transiently involve single-stranded regions. DNA, which consists of a polysugar-phosphate backbone possessing projections of purines (adenine and guanine) and pyrimidines (thymine and cytosine), forms a double helix that is held together by hydrogen bonds between these purines and pyrimidines (adenine to thymine and guanine to cytosine).
Filamentous proteins that are the main constituent of the thin filaments of muscle fibers. The filaments (known also as filamentous or F-actin) can be dissociated into their globular subunits; each subunit is composed of a single polypeptide 375 amino acids long. This is known as globular or G-actin. In conjunction with MYOSINS, actin is responsible for the contraction and relaxation of muscle.
A 51-amino acid pancreatic hormone that plays a major role in the regulation of glucose metabolism, directly by suppressing endogenous glucose production (GLYCOGENOLYSIS; GLUCONEOGENESIS) and indirectly by suppressing GLUCAGON secretion and LIPOLYSIS. Native insulin is a globular protein comprised of a zinc-coordinated hexamer. Each insulin monomer containing two chains, A (21 residues) and B (30 residues), linked by two disulfide bonds. Insulin is used as a drug to control insulin-dependent diabetes mellitus (DIABETES MELLITUS, TYPE 1).
Apoptosis Regulatory Proteins
src Homology Domains
Regions of AMINO ACID SEQUENCE similarity in the SRC-FAMILY TYROSINE KINASES that fold into specific functional tertiary structures. The SH1 domain is a CATALYTIC DOMAIN. SH2 and SH3 domains are protein interaction domains. SH2 usually binds PHOSPHOTYROSINE-containing proteins and SH3 interacts with CYTOSKELETAL PROTEINS.
A macrolide compound obtained from Streptomyces hygroscopicus that acts by selectively blocking the transcriptional activation of cytokines thereby inhibiting cytokine production. It is bioactive only when bound to IMMUNOPHILINS. Sirolimus is a potent immunosuppressant and possesses both antifungal and antineoplastic properties.
Members of the class of compounds composed of AMINO ACIDS joined together by peptide bonds between adjacent amino acids into linear, branched or cyclical structures. OLIGOPEPTIDES are composed of approximately 2-12 amino acids. Polypeptides are composed of approximately 13 or more amino acids. PROTEINS are linear polypeptides that are normally synthesized on RIBOSOMES.
Promoter Regions, Genetic
Components of a cell produced by various separation techniques which, though they disrupt the delicate anatomy of a cell, preserve the structure and physiology of its functioning constituents for biochemical and ultrastructural analysis. (From Alberts et al., Molecular Biology of the Cell, 2d ed, p163)
Oncogene Protein v-akt
A Drosophila TNF-receptor-associated factor (TRAF) binds the ste20 kinase Misshapen and activates Jun kinase. (1/27527)Two families of protein kinases that are closely related to Ste20 in their kinase domain have been identified - the p21-activated protein kinase (Pak) and SPS1 families [1-3]. In contrast to Pak family members, SPS1 family members do not bind and are not activated by GTP-bound p21Rac and Cdc42. We recently placed a member of the SPS1 family, called Misshapen (Msn), genetically upstream of the c-Jun amino-terminal (JNK) mitogen-activated protein (MAP) kinase module in Drosophila . The failure to activate JNK in Drosophila leads to embryonic lethality due to the failure of these embryos to stimulate dorsal closure [5-8]. Msn probably functions as a MAP kinase kinase kinase kinase in Drosophila, activating the JNK pathway via an, as yet, undefined MAP kinase kinase kinase. We have identified a Drosophila TNF-receptor-associated factor, DTRAF1, by screening for Msn-interacting proteins using the yeast two-hybrid system. In contrast to the mammalian TRAFs that have been shown to activate JNK, DTRAF1 lacks an amino-terminal 'Ring-finger' domain, and overexpression of a truncated DTRAF1, consisting of only its TRAF domain, activates JNK. We also identified another DTRAF, DTRAF2, that contains an amino-terminal Ring-finger domain. Msn specifically binds the TRAF domain of DTRAF1 but not that of DTRAF2. In Drosophila, DTRAF1 is thus a good candidate for an upstream molecule that regulates the JNK pathway by interacting with, and activating, Msn. Consistent with this idea, expression of a dominant-negative Msn mutant protein blocks the activation of JNK by DTRAF1. Furthermore, coexpression of Msn with DTRAF1 leads to the synergistic activation of JNK. We have extended some of these observations to the mammalian homolog of Msn, Nck-interacting kinase (NIK), suggesting that TRAFs also play a critical role in regulating Ste20 kinases in mammals. (+info)
Intracellular signalling: PDK1--a kinase at the hub of things. (2/27527)Phosphoinositide-dependent kinase 1 (PDK1) is at the hub of many signalling pathways, activating PKB and PKC isoenzymes, as well as p70 S6 kinase and perhaps PKA. PDK1 action is determined by colocalization with substrate and by target site availability, features that may enable it to operate in both resting and stimulated cells. (+info)
Transformation mediated by RhoA requires activity of ROCK kinases. (3/27527)BACKGROUND: The Ras-related GTPase RhoA controls signalling processes required for cytoskeletal reorganisation, transcriptional regulation, and transformation. The ability of RhoA mutants to transform cells correlates not with transcription but with their ability to bind ROCK-I, an effector kinase involved in cytoskeletal reorganisation. We used a recently developed specific ROCK inhibitor, Y-27632, and ROCK truncation mutants to investigate the role of ROCK kinases in transcriptional activation and transformation. RESULTS: In NIH3T3 cells, Y-27632 did not prevent the activation of serum response factor, transcription of c-fos or cell cycle re-entry following serum stimulation. Repeated treatment of NIH3T3 cells with Y-27632, however, substantially disrupted their actin fibre network but did not affect their growth rate. Y-27632 blocked focus formation by RhoA and its guanine-nucleotide exchange factors Dbl and mNET1. It did not affect the growth rate of cells transformed by Dbl and mNET1, but restored normal growth control at confluence and prevented their growth in soft agar. Y-27632 also significantly inhibited focus formation by Ras, but had no effect on the establishment or maintenance of transformation by Src. Furthermore, it significantly inhibited anchorage-independent growth of two out of four colorectal tumour cell lines. Consistent with these data, a truncated ROCK derivative exhibited weak ability to cooperate with activated Raf in focus formation assays. CONCLUSIONS: ROCK signalling is required for both the establishment and maintenance of transformation by constitutive activation of RhoA, and contributes to the Ras-transformed phenotype. These observations provide a potential explanation for the requirement for Rho in Ras-mediated transformation. Moreover, the inhibition of ROCK kinases may be of therapeutic use. (+info)
DMPK dosage alterations result in atrioventricular conduction abnormalities in a mouse myotonic dystrophy model. (4/27527)Myotonic dystrophy (DM) is the most common form of muscular dystrophy and is caused by expansion of a CTG trinucleotide repeat on human chromosome 19. Patients with DM develop atrioventricular conduction disturbances, the principal cardiac manifestation of this disease. The etiology of the pathophysiological changes observed in DM has yet to be resolved. Haploinsufficiency of myotonic dystrophy protein kinase (DMPK), DM locus-associated homeodomain protein (DMAHP) and/or titration of RNA-binding proteins by expanded CUG sequences have been hypothesized to underlie the multi-system defects observed in DM. Using an in vivo murine electrophysiology study, we show that cardiac conduction is exquisitely sensitive to DMPK gene dosage. DMPK-/- mice develop cardiac conduction defects which include first-, second-, and third-degree atrioventricular (A-V) block. Our results demonstrate that the A-V node and the His-Purkinje regions of the conduction system are specifically compromised by DMPK loss. Importantly, DMPK+/- mice develop first-degree heart block, a conduction defect strikingly similar to that observed in DM patients. These results demonstrate that DMPK dosage is a critical element modulating cardiac conduction integrity and conclusively link haploinsufficiency of DMPK with cardiac disease in myotonic dystrophy. (+info)
Differential stability of the DNA-activated protein kinase catalytic subunit mRNA in human glioma cells. (5/27527)DNA-dependent protein kinase (DNA-PK) functions in double-strand break repair and immunoglobulin [V(D)J] recombination. We previously established a radiation-sensitive human cell line, M059J, derived from a malignant glioma, which lacks the catalytic subunit (DNA-PKcs) of the DNA-PK multiprotein complex. Although previous Northern blot analysis failed to detect the DNA-PKcs transcript in these cells, we show here through quantitative studies that the transcript is present, albeit at greatly reduced (approximately 20x) levels. Sequencing revealed no genetic alteration in either the promoter region, the kinase domain, or the 3' untranslated region of the DNA-PKcs gene to account for the reduced transcript levels. Nuclear run-on transcription assays indicated that the rate of DNA-PKcs transcription in M059J and DNA-PKcs proficient cell lines was similar, but the stability of the DNA-PKcs message in the M059J cell line was drastically (approximately 20x) reduced. Furthermore, M059J cells lack an alternately spliced DNA-PKcs transcript that accounts for a minor (5-20%) proportion of the DNA-PKcs message in all other cell lines tested. Thus, alterations in DNA-PKcs mRNA stability and/or the lack of the alternate mRNA may result in the loss of DNA-PKcs activity. This finding has important implications as DNA-PKcs activity is essential to cells repairing damage induced by radiation or radiomimetric agents. (+info)
Cyclin D-CDK subunit arrangement is dependent on the availability of competing INK4 and p21 class inhibitors. (6/27527)The D-type cyclins and their major kinase partners CDK4 and CDK6 regulate G0-G1-S progression by contributing to the phosphorylation and inactivation of the retinoblastoma gene product, pRB. Assembly of active cyclin D-CDK complexes in response to mitogenic signals is negatively regulated by INK4 family members. Here we show that although all four INK4 proteins associate with CDK4 and CDK6 in vitro, only p16(INK4a) can form stable, binary complexes with both CDK4 and CDK6 in proliferating cells. The other INK4 family members form stable complexes with CDK6 but associate only transiently with CDK4. Conversely, CDK4 stably associates with both p21(CIP1) and p27(KIP1) in cyclin-containing complexes, suggesting that CDK4 is in equilibrium between INK4 and p21(CIP1)- or p27(KIP1)-bound states. In agreement with this hypothesis, overexpression of p21(CIP1) in 293 cells, where CDK4 is bound to p16(INK4a), stimulates the formation of ternary cyclin D-CDK4-p21(CIP1) complexes. These data suggest that members of the p21 family of proteins promote the association of D-type cyclins with CDKs by counteracting the effects of INK4 molecules. (+info)
Phosphorylation of the cap-binding protein eukaryotic translation initiation factor 4E by protein kinase Mnk1 in vivo. (7/27527)Eukaryotic translation initiation factor 4E (eIF4E) binds to the mRNA 5' cap and brings the mRNA into a complex with other protein synthesis initiation factors and ribosomes. The activity of mammalian eIF4E is important for the translation of capped mRNAs and is thought to be regulated by two mechanisms. First, eIF4E is sequestered by binding proteins, such as 4EBP1, in quiescent cells. Mitogens induce the release of eIF4E by stimulating the phosphorylation of 4EBP1. Second, mitogens and stresses induce the phosphorylation of eIF4E at Ser 209, increasing the affinity of eIF4E for capped mRNA and for an associated scaffolding protein, eIF4G. We previously showed that a mitogen- and stress-activated kinase, Mnk1, phosphorylates eIF4E in vitro at the physiological site. Here we show that Mnk1 regulates eIF4E phosphorylation in vivo. Mnk1 binds directly to eIF4G and copurifies with eIF4G and eIF4E. We identified activating phosphorylation sites in Mnk1 and developed dominant-negative and activated mutants. Expression of dominant-negative Mnk1 reduces mitogen-induced eIF4E phosphorylation, while expression of activated Mnk1 increases basal eIF4E phosphorylation. Activated mutant Mnk1 also induces extensive phosphorylation of eIF4E in cells overexpressing 4EBP1. This suggests that phosphorylation of eIF4E is catalyzed by Mnk1 or a very similar kinase in cells and is independent of other mitogenic signals that release eIF4E from 4EBP1. (+info)
Signals from the Ras, Rac, and Rho GTPases converge on the Pak protein kinase in Rat-1 fibroblasts. (8/27527)Ras plays a key role in regulating cellular proliferation, differentiation, and transformation. Raf is the major effector of Ras in the Ras > Raf > Mek > extracellular signal-activated kinase (ERK) cascade. A second effector is phosphoinositide 3-OH kinase (PI 3-kinase), which, in turn, activates the small G protein Rac. Rac also has multiple effectors, one of which is the serine threonine kinase Pak (p65(Pak)). Here we show that Ras, but not Raf, activates Pak1 in cotransfection assays of Rat-1 cells but not NIH 3T3 cells. We tested agents that activate or block specific components downstream of Ras and demonstrate a Ras > PI 3-kinase > Rac/Cdc42 > Pak signal. Although these studies suggest that the signal from Ras through PI 3-kinase is sufficient to activate Pak, additional studies suggested that other effectors contribute to Pak activation. RasV12S35 and RasV12G37, two effector mutant proteins which fail to activate PI 3-kinase, did not activate Pak when tested alone but activated Pak when they were cotransfected. Similarly, RacV12H40, an effector mutant that does not bind Pak, and Rho both cooperated with Raf to activate Pak. A dominant negative Rho mutant also inhibited Ras activation of Pak. All combinations of Rac/Raf and Ras/Raf and Rho/Raf effector mutants that transform cells cooperatively stimulated ERK. Cooperation was Pak dependent, since all combinations were inhibited by kinase-deficient Pak mutants in both transformation assays and ERK activation assays. These data suggest that other Ras effectors can collaborate with PI 3-kinase and with each other to activate Pak. Furthermore, the strong correlation between Pak activation and cooperative transformation suggests that Pak activation is necessary, although not sufficient, for cooperative transformation of Rat-1 fibroblasts by Ras, Rac, and Rho. (+info)
Mark4 - MAP/microtubule affinity-regulating kinase 4 - Mus musculus (Mouse) - Mark4 gene & protein
Serine/threonine-protein kinase (By similarity). Phosphorylates the microtubule-associated protein MAPT/TAU (By similarity). Also phosphorylates the microtubule-associated proteins MAP2 and MAP4 (By similarity). Involved in regulation of the microtubule network, causing reorganization of microtubules into bundles (By similarity). Required for the initiation of axoneme extension during cilium assembly (By similarity). Regulates the centrosomal location of ODF2 and phosphorylates ODF2 in vitro (By similarity). Plays a role in cell cycle progression, specifically in the G1/S checkpoint (By similarity). Reduces neuronal cell survival (By similarity). Plays a role in energy homeostasis by regulating satiety and metabolic rate (PubMed:22992738). Promotes adipogenesis by activating JNK1 and inhibiting the p38MAPK pathway, and triggers apoptosis by activating the JNK1 pathway (PubMed:24989893). Phosphorylates mTORC1 complex member RPTOR and acts as a negative regulator of the mTORC1 complex, probably due to
Salt-Inducible Kinases: Physiology, Regulation by cAMP, and Therapeutic Potential
Salt-inducible kinases (SIKs) represent a subfamily of AMP-activated protein kinase (AMPK) family kinases. Initially named because SIK1 (the founding member of this kinase family) expression is regulated by dietary salt intake in the adrenal gland, it is now apparent that a major biological role of …
Dual Specificity Protein Kinase TTK (TTK Protein Kinase or Cancer/Testis Antigen 96 or Monopolar Spindle 1-Like 1 or EC 2.7.12...
Dual Specificity Protein Kinase TTK (TTK Protein Kinase or Cancer/Testis Antigen 96 or Monopolar Spindle 1-Like 1 or EC 18.104.22.168) - Pipeline Review, H1 2016 - Market research report and industry analysis - 10249099
IJMS | Free Full-Text | Recent Progress on Liver Kinase B1 (LKB1): Expression, Regulation, Downstream Signaling and Cancer...
Liver kinase B1 (LKB1), known as a serine/threonine kinase, has been identified as a critical cancer suppressor in many cancer cells. It is a master upstream kinase of 13 AMP-activated protein kinase (AMPK)-related protein kinases, and possesses versatile biological functions. LKB1 gene is mutated in many cancers, and its protein can form different protein complexes with different cellular localizations in various cell types. The expression of LKB1 can be regulated through epigenetic modification, transcriptional regulation and post-translational modification. LKB1 dowcnstream pathways mainly include AMPK, microtubule affinity regulating kinase (MARK), salt-inducible kinase (SIK), sucrose non-fermenting protein-related kinase (SNRK) and brain selective kinase (BRSK) signalings, etc. This review, therefore, mainly discusses recent studies about the expression, regulation, downstream signaling and cancer suppressive function of LKB1, which can be helpful for better understanding of this molecular and
Alcohol Interacts with Genetic Alteration of the Hippo Tumor Suppressor Pathway to Modulate Tissue Growth in Drosophila
Alcohol-mediated cancers represent more than 3.5% of cancer-related deaths, yet how alcohol promotes cancer is a major open question. Using Drosophila, we identified novel interactions between dietary ethanol and loss of tumor suppressor components of the Hippo Pathway. The Hippo Pathway suppresses tumors in flies and mammals by inactivating transcriptional co-activator Yorkie, and the spectrum of cancers associated with impaired Hippo signaling overlaps strikingly with those associated with alcohol. Therefore, our findings may implicate loss of Hippo Pathway tumor suppression in alcohol-mediated cancers. Ethanol enhanced overgrowth from loss of the expanded, hippo, or warts tumor suppressors but, surprisingly, not from over-expressing the yorkie oncogene. We propose that in parallel to Yorkie-dependent overgrowth, impairing Hippo signaling in the presence of alcohol may promote overgrowth via additional alcohol-relevant targets. We also identified interactions between alcohol and Hippo Pathway over
Ischemic axonal injury up-regulates MARK4 in cortical neurons and primes tau phosphorylation and aggregation | Acta...
Ischemic injury to white matter tracts is increasingly recognized to play a key role in age-related cognitive decline, vascular dementia, and Alzheimers disease. Knowledge of the effects of ischemic axonal injury on cortical neurons is limited yet critical to identifying molecular pathways that link neurodegeneration and ischemia. Using a mouse model of subcortical white matter ischemic injury coupled with retrograde neuronal tracing, we employed magnetic affinity cell sorting with fluorescence-activated cell sorting to capture layer-specific cortical neurons and performed RNA-sequencing. With this approach, we identified a role for microtubule reorganization within stroke-injured neurons acting through the regulation of tau. We find that subcortical stroke-injured Layer 5 cortical neurons up-regulate the microtubule affinity-regulating kinase, Mark4, in response to axonal injury. Stroke-induced up-regulation of Mark4 is associated with selective remodeling of the apical dendrite after stroke and the
Serine/Threonine Protein Kinase DCLK1 (Doublecortin Domain Containing Protein 3A or Doublecortin Like And CAM Kinase Like 1 or...
Serine/Threonine Protein Kinase DCLK1 (Doublecortin Domain Containing Protein 3A or Doublecortin Like And CAM Kinase Like 1 or Doublecortin Like Kinase 1 or DCLK1 or EC 22.214.171.124) - Drugs in Development, 2021 provides in depth analysis on Serine/Threonine Protein Kinase DCLK1 (Doublecortin Domain Containing Protein 3A or Doublecortin Like And CAM Kinase Like 1 or Doublecortin Like Kinase 1 or DCLK1 or EC 126.96.36.199) targeted pipeline therapeutics. The report provides comprehensive information complete with Analysis by Indications, Stage of Development, Mechanism of Action (MoA), Route of Administration (RoA) and Molecule Type. The report also covers the descriptive pharmacological action of the therapeutics, its complete research and development history and latest news and press releases. Additionally, the report provides an overview of key players involved in Serine/Threonine Protein Kinase DCLK1 (Doublecortin Domain Containing Protein 3A or Doublecortin Like And CAM Kinase Like 1 or Doublecortin ...
OriGene - MARK1 (NM 018650) Human ORF cDNA Clone
MARK1 - MARK1 (GFP-tagged) - Human MAP/microtubule affinity-regulating kinase 1 (MARK1) available for purchase from OriGene - Your Gene Company.
OriGene - Mark3 (BC026445) Human ORF cDNA Clone
Mark3 - Mark3 (Myc-DDK-tagged) - Mouse MAP/microtubule affinity-regulating kinase 3 (cDNA clone MGC:31426 IMAGE:4459439) available for purchase from OriGene - Your Gene Company.
Global RAC Beta Serine/Threonine Protein Kinase Market Growth Analysis, Forecasts to 2025 - Almac Discovery Ltd, ArQule Inc,...
The RAC Beta Serine/Threonine Protein Kinase Market research report presents an all-inclusive study of the global RAC Beta Serine/Threonine Protein Kinase market. The report includes all the major trends and technologies performing a major role in the RAC Beta Serine/Threonine Protein Kinase market development during forecast period. The key players in the market are Almac Discovery Ltd, ArQule Inc, AstraZeneca Plc, Bayer AG, Critical Outcome Technologies Inc, Merck & Co Inc, Novartis AG. An attractiveness study has been presented for each geographic area in the report to provide a comprehensive analysis of the overall competitive scenario of the RAC Beta Serine/Threonine Protein Kinase market globally.. Apply here for the SAMPLE copy of the report @: https://www.promarketresearch.com/request-for-sample.html?repid=24915. Furthermore, the report comprises an outline of the diverse tactics used by the key players in the market. It also details the competitive scenario of the RAC Beta ...
Tousled-like kinase regulates cytokine-mediated communication between cooperating cell types during collective border cell...
p,Collective cell migration is emerging as a major contributor to normal development and disease. Collective movement of border cells in the Drosophila ovary requires cooperation between two distinct cell types: four to six migratory cells surrounding two immotile cells called polar cells. Polar cells secrete a cytokine, Unpaired (Upd), which activates JAK/STAT signaling in neighboring cells, stimulating their motility. Without Upd, migration fails, causing sterility. Ectopic Upd expression is sufficient to stimulate motility in otherwise immobile cells. Thus regulation of Upd is key. Here we report a limited RNAi screen for nuclear proteins required for border cell migration, which revealed that the gene encoding Tousled-like kinase (Tlk) is required in polar cells for Upd expression without affecting polar cell fate. In the absence of Tlk, fewer border cells are recruited and motility is impaired, similar to inhibition of JAK/STAT signaling. We further show that Tlk in polar cells is required ...
Exercise-Induced Catecholamines Activate the Hippo Tumor Suppressor Pathway to Reduce Risks of Breast Cancer Development |...
Strong epidemiologic evidence documents the protective effect of physical activity on breast cancer risk, recurrence, and mortality, but the underlying mechanisms remain to be identified. Using human exercise-conditioned serum for breast cancer cell incubation studies and murine exercise interventions, we aimed to identify exercise factors and signaling pathways involved in the exercise-dependent suppression of breast cancer. Exercise-conditioned serum from both women with breast cancer (n = 20) and healthy women (n = 7) decreased MCF-7 (hormone-sensitive) and MDA-MB-231 (hormone-insensitive) breast cancer cell viability in vitro by 11% to 19% and reduced tumorigenesis by 50% when preincubated MCF-7 breast cancer cells were inoculated into NMRI-Foxn1nu mice. This exercise-mediated suppression of cell viability and tumor formation was completely blunted by blockade of β-adrenergic signaling in MCF-7 cells, indicating that catecholamines were the responsible exercise factors. Both epinephrine ...
TSSK5, a novel member of the testis-specific serine/threonine kinase family, phosphorylates CREB at Ser-133, and stimulates the...
Several protein kinases have been shown to be involved in spermatogenesis. Recently, a novel subfamily of serine/threonine kinases has been isolated whose expression is limited to testis. Here, we report the fifth family member, named TSSK5, which encodes a 328 amino acid protein. RT-PCR analysis sh …
The Hippo Tumor Suppressor Pathway: A Brainstorming Workshop | Science Signaling
Researchers from around the world met for two days in April this year in Rome, Italy, to discuss progress in the rapidly developing field of Hippo signaling, which is relevant to cancer and the control of organ size. Most of the participants presented data related to previously uncharacterized proteins that physically and functionally interact with known components of the Hippo pathway and regulate its biological output.. ...
The activation of protein kinase B by H2O2 or heat shock is mediated by phosphoinositide 3-kinase and not by mitogen-activated...
Protein kinase B (PKB) isoforms became activated [and glycogen synthase kinase-3 (GSK3) became inhibited] when mouse Swiss 3T3 fibroblasts were exposed to oxidative stress (H2O2) or heat shock, but not when they were exposed to osmotic shock (0.5 M sorbitol or 0.7 M NaCl), chemical stress (sodium arsenite), the protein-synthesis inhibitor anisomycin, or UV radiation. In contrast, all seven stimuli activated mitogen-activated protein kinase-activated protein kinase-2 (MAPKAP-K2). The activation of MAPKAP-K2 was suppressed by the drug SB 203580, but not by inhibitors of phosphoinositide (phosphatidylinositide, PI) 3-kinase. In contrast, the activation of PKB isoforms and the inhibition of GSK3 by oxidative stress or heat shock were prevented by inhibitors of PI 3-kinase, but not by SB 203580. Thus the activation of PKB by oxidative stress or heat shock is mediated by PI 3-kinase and not by MAPKAP-K2. PKBα and PKBγ were also activated by heat shock and oxidative stress in human embryonic kidney ...
RAC Gamma Serine/Threonine Protein Kinase (Protein Kinase Akt 3 or Protein Kinase B Gamma or RAC PK Gamma or STK 2 or AKT3 or...
RAC Gamma Serine/Threonine Protein Kinase (Protein Kinase Akt 3 or Protein Kinase B Gamma or RAC PK Gamma or STK 2 or AKT3 or EC 188.8.131.52) - Pipeline Review, H2 2017 Size and Share Published in 2017-08-29 Available for US$ 3500 at Researchmoz.us
MAP Kinase Interacting Serine/Threonine Protein Kinase 1 (MAP Kinase Signal Integrating Kinase 1 or MKNK1 or EC 184.108.40.206) -...
Price for Single User $ 3080 USD :: MAP Kinase Interacting Serine/Threonine Protein Kinase 1 (MAP Kinase Signal Integrating Kinase 1 or MKNK1 or EC 220.127.116.11) - Pipeline Review, H2 2016SummaryGlobal Markets Directs, MAP Kinase Interacting Serine/Threonine Protein Kinase 1 (MAP Kinase
Cyclin Dependent Kinase 9 (Tat Associated Kinase Complex Catalytic Subunit or C 2K or Cell Division Cycle 2 Like Protein Kinase...
[92 Pages Report] Check for Discount on Cyclin Dependent Kinase 9 (Tat Associated Kinase Complex Catalytic Subunit or C 2K or Cell Division Cycle 2 Like Protein Kinase 4 or Cell Division Protein Kinase 9 or Serine/Threonine Protein Kinase PITALR or CDK9 or EC 18.104.22.168 or EC 22.214.171.124) - Pipeli report by Global Markets Direct. Cyclin Dependent Kinase 9 (Tat Associated Kinase Complex Catalytic Subunit...
MAP2K1 - Dual specificity mitogen-activated protein kinase kinase 1 - Cricetulus griseus (Chinese hamster) - MAP2K1 gene &...
Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in the extracellular signal-regulated kinases MAPK3/ERK1 and MAPK1/ERK2, leading to their activation and further transduction of the signal within the MAPK/ERK cascade. Depending on the cellular context, this pathway mediates diverse biological functions such as cell growth, adhesion, survival and differentiation, predominantly through the regulation of transcription, metabolism and cytoskeletal rearrangements. One target of the MAPK/ERK cascade
Mitotic Checkpoint Serine/Threonine Protein Kinase (Bub) Research Areas: R&D Systems
Find Mitotic Checkpoint Serine/Threonine Protein Kinase (Bub) research area related information and Mitotic Checkpoint Serine/Threonine Protein Kinase (Bub) research products from R&D Systems. Learn more.
ELM - Detail for MOD LATS 1
LATS1/LATS2 are primarily considered as central players in the Hippo tumour suppressor pathway, however they also participate in a range of other signalling pathways. (Zhao,2010). The core of the Hippo pathway consists of Hpo, Wts, Sav and Mats. Hippo (Hpo) is a Ste20 family protein kinase that complexes with the regulatory scaffold protein Salvador (Sav). The Hpo/Sav complex then phosphorylates and activates Warts (Wts). Wts has an activating subunit Mats. The active Wts/Mats complex then in turn phosphorylates the transcriptional co-activators Yorkie (Yki) in flies, and YAP and TAZ in mammals. Phosphorylation of these transcriptional co-activators leads to their association with 14-3-3 family proteins, cytoplasmic retention and inactivation (Zhao,2007). In the presence of active CK1 kinase, LATS1/2 mediated phosphorylation of YAP also leads to the recruitment of the beta-TRCP SCF E3 ligase thereby triggering the subsequent proteasomal degradation of YAP (Zhao,2010). The LATS kinases prefer to ...
Cellular energy stress induces AMPK-mediated regulation of YAP and the Hippo pathway.
Author(s): Mo, Jung-Soon; Meng, Zhipeng; Kim, Young Chul; Park, Hyun Woo; Hansen, Carsten Gram; Kim, Soohyun; Lim, Dae-Sik; Guan, Kun-Liang | Abstract: YAP (Yes-associated protein) is a transcription co-activator in the Hippo tumour suppressor pathway and controls cell growth, tissue homeostasis and organ size. YAP is inhibited by the kinase Lats, which phosphorylates YAP to induce its cytoplasmic localization and proteasomal degradation. YAP induces gene expression by binding to the TEAD family transcription factors. Dysregulation of the Hippo-YAP pathway is frequently observed in human cancers. Here we show that cellular energy stress induces YAP phosphorylation, in part due to AMPK-dependent Lats activation, thereby inhibiting YAP activity. Moreover, AMPK directly phosphorylates YAP Ser 94, a residue essential for the interaction with TEAD, thus disrupting the YAP-TEAD interaction. AMPK-induced YAP inhibition can suppress oncogenic transformation of Lats-null cells with high YAP activity. Our study
Cyclin Dependent Kinase 6 (Cell Division Protein Kinase 6 or Serine/Threonine Protein Kinase PLSTIRE or CDK6 or EC 126.96.36.199) -...
[103 Pages Report] Check for Discount on Cyclin Dependent Kinase 6 (Cell Division Protein Kinase 6 or Serine/Threonine Protein Kinase PLSTIRE or CDK6 or EC 188.8.131.52) - Pipeline Review, H2 2017 report by Global Markets Direct. Cyclin Dependent Kinase 6 (Cell Division Protein Kinase 6 or...
MEKK3 is a conserved Ser/Thr proteins kinase belonging to the MAPK - Drug Resistance to EGFR Inhibitors in Lung Cancer
MEKK3 is a conserved Ser/Thr proteins kinase belonging to the MAPK kinase kinase (MAP3K) family members. the T-cKO rodents (23). Identical phenotype in peripheral Capital t cells homeostasis was also reported by another group with individually produced T-cKO rodents (24). To understand Talampanel supplier additional the physical part of MEKK3 in Capital t cell-mediated adaptive defenses, we researched the function of T-cKO rodents had been referred to previously (23). All rodents had been on C57BD/6 history and utilized between 6 and 12 wk of age group. Our rodents had been encased in a pathogen-free pet treatment service at Meters.D. Anderson Cancers Middle (Houston, Texas) or Yale School (New Dreamland, CT). All mouse trials were approved by the Institutional Pet Use and Treatment Committees of the School of Texas M.D. Anderson Cancers Yale and Middle School. Immunization Eight-week-old rodents had been utilized for the immunization. A mix of 1 mg/ml Ovum (Sigma-Aldrich, St. Louis, MO) and 1 ...
GT:ID BAD55749.1 GT:GENE BAD55749.1 GT:PRODUCT putative serine/threonine protein kinase GT:DATABASE GIB00210CH01 GT:ORG nfar0 GB:ACCESSION GIB00210CH01 GB:LOCATION complement(1006060..1007184) GB:FROM 1006060 GB:TO 1007184 GB:DIRECTION - GB:PRODUCT putative serine/threonine protein kinase GB:PROTEIN_ID BAD55749.1 LENGTH 374 SQ:AASEQ MIDRARPIVGPDYLVAGRYRLQSKLGGGGMGAVWLAHDRLLDRDVAIKQVLSTAGLPEAEAARIREQIMHEGRVAAKLSHEHAIAVYDVVLEAGEPWLVMEHLPSRSVARALGLVDTLPVLEVAQIGAQVADALAAAHAVGIVHRDIKPGNILVADRGPRVGFAKLSDFGISRGAGETSDEPDGIITGTPAYLPPEVARGAQPTAASDVFSLGATLYTAIEGQPPFGMDDDSDAVVQRAAMAQIIPPSRSGVLTDALLHMMEPAPQRRPTMAEARDEILTAAFGPGTASYILGAPVRTEDGTIPSWATRNGAIGLRSPHSAPLPRPHRGASAANAPAAQRARVAAPRQTNAALAVTIGLLIGLIIIIGVIVVAM GT:EXON 1,1-374:0, BL:SWS:NREP 1 BL:SWS:REP 3-,268,PKN2_CORGL,1e-26,34.0,250/469, PROS 25-,48,PS00107,PROTEIN_KINASE_ATP,PDOC00100, PROS 142-,154,PS00108,PROTEIN_KINASE_ST,PDOC00100, TM:NTM 1 TM:REGION 351-,373, SEG 124-,144,aqigaqvadalaaahavgivh, SEG 326-,347,phrgasaanapaaqrarvaapr, SEG ...
Research programme: protein serine threonine kinase inhibitors - BioBlocks/Visionary Pharmaceuticals - AdisInsight
BioBlocks and Visionary Pharmaceuticals are collaborating to develop small molecule protein serine threonine kinase inhibitors, specifically serum- and
Results for cd05122
Catalytic domain of STE family Protein Kinases. Protein Kinases (PKs), STE family, catalytic (c) domain. PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine or tyrosine residues on protein substrates. The STE family is part of a larger superfamily that includes the catalytic domains of other protein serine/threonine kinases (STKs), protein tyrosine kinases (PTKs), RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase (PI3K). This family is composed of STKs, and some dual-specificity PKs that phosphorylate both threonine and tyrosine residues of target proteins. Most members are kinases involved in mitogen-activated protein kinase (MAPK) signaling cascades, acting as MAPK kinases (MAPKKs), MAPK kinase kinases (MAPKKKs), or MAPK kinase kinase kinases (MAP4Ks). The MAPK signaling pathways are important mediators of cellular responses to extracellular signals. The pathways involve a triple kinase core cascade comprising of the ...
Understanding the Polo Kinase machine. | IRIC - Institut de recherche en immunologie et en cancérologie de lUniversité de...
The Polo Kinase is a central regulator of cell division required for several events of mitosis and cytokinesis. In addition to a kinase domain (KD), Polo-like kinases (Plks) comprise a Polo-Box domain (PBD), which mediates protein interactions with targets and regulators of Plks. In all organisms that contain Plks, one Plk family member fulfills several essential functions in the regulation of cell division, and here we refer to this conserved protein as Polo Kinase (Plk1 in humans). The PBD and the KD are capable of both cooperation and mutual inhibition in their functions. Crystal structures of the PBD, the KD and, recently, a PBD-KD complex have helped understanding the inner workings of the Polo Kinase. In parallel, an impressive array of molecular mechanisms has been found to mediate the regulation of the protein. Moreover, the targeting of Polo Kinase in the development of anti-cancer drugs has yielded several molecules with which to chemically modulate Polo Kinase to study its biological ...
transmembrane receptor protein serine/threonine kinase activity QuickView - Correlation Engine
Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + pro…
NDR kinases are essential for growth, cardiac developme | Open-i
NDR kinases are essential for growth, cardiac development and blood vessel remodeling from about embryonic day 8 onward in mouse embryos.(A, B) Bright field ima
MAP Kinase Interacting Serine/Threonine Protein Kinase 2 (MAP Kinase Signal Integrating Kinase 2 or MKNK2 or EC 184.108.40.206) -...
Global Markets Directs, MAP Kinase Interacting Serine/Threonine Protein Kinase 2 (MAP Kinase Signal Integrating Kinase 2 or MKNK2 or EC
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The protein encoded by this gene is a member of the dual specificity protein kinase family, which acts as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein kinase lies upstream of MAP kinases and stimulates the enzymatic activity of MAP kinases upon wide variety of extra- and intracellular signals. As an essential component of MAP kinase signal transduction pathway, this kinase is involved in many cellular processes such as proliferation, differentiation, transcription regulation and development ...
Results for cd05623
Catalytic domain of the Protein Serine/Threonine Kinase, DMPK-related cell division control protein 42 binding kinase alpha. Serine/Threonine Kinases (STKs), DMPK-like subfamily, DMPK-related cell division control protein 42 (Cdc42) binding kinase (MRCK) alpha isoform, catalytic (c) domain. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The DMPK-like subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase. MRCK is activated via interaction with the small GTPase Cdc42. MRCK/Cdc42 signaling mediates myosin-dependent cell motility. MRCKalpha is expressed ubiquitously in many tissues. It plays a role in the regulation of peripheral actin reorganization and neurite outgrowth. It may also play a role in the transferrin iron uptake pathway. ...
Integrin-linked kinase (ILK) and its interactors | JCB
ILK has a low basal kinase activity, which is stimulated transiently by cell-ECM interactions and by certain growth factors (Dedhar, 2000). The activity is stimulated in a phosphatidylinositol (PI) 3-kinase-dependent manner and likely involves binding of the phosphoinositide phospholipid product of PI 3-kinase, PI 3,4,5-triphosphate, to the PH-like domain of ILK (Dedhar, 2000). ILK activity is regulated negatively by two phosphatases: PTEN, a tumor suppressor lipid phosphatase, which dephosphorylates PI 3,4,5-triphosphate to PI 4,5-bisphosphate, and a PP2C protein phosphatase, ILKAP (Morimoto et al., 2000; Persad et al., 2000; 2001b; Leung-Hagesteijn et al., 2001). ILK activity is activated constitutively in PTEN-null tumor cells (Persad et al., 2000, 2001b). Both PI 3,4,5-triphosphate binding and (auto)phosphorylation appear to be crucial for ILK activation, since mutations in the PH domain (Arg 211) or in the activation loop serine (ser) 343 render the kinase inactive and unable to ...
Protein kinase networks that limit TLR signalling | Biochemical Society Transactions
TLRs (Toll-like receptors) detect invading micro-organisms which triggers the production of pro-inflammatory mediators needed to combat infection. Although these signalling networks are required to protect the host against invading pathogens, dysregulation of TLR pathways contributes to the development of chronic inflammatory diseases and autoimmune disorders. Molecular mechanisms have therefore evolved to restrict the strength of TLR signalling. In the present review, I highlight recent advances in our understanding of the protein kinase networks required to suppress the innate immune response by negatively regulating TLR signalling and/or promoting the secretion of anti-inflammatory cytokines. I present my discoveries on the key roles of the IKK (inhibitor of nuclear factor κB kinase)-related kinases and the SIKs (salt-inducible kinases) in limiting innate immunity within the greater context of the field.. ...
Mutagenetix > Incidental...
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of the serine/threonine kinase family. This kinase contains a SH3 domain and a leucine zipper-basic motif. This kinase preferentially activates MAPK8/JNK kinase, and functions as a positive regulator of JNK signaling pathway. This kinase can directly phosphorylate, and activates IkappaB kinase alpha and beta, and is found to be involved in the transcription activity of NF-kappaB mediated by Rho family GTPases and CDC42. [provided by RefSeq, Jul 2008 ...
3mbl - Proteopedia, life in 3D
MP2K1_HUMAN] Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in the extracellular signal-regulated kinases MAPK3/ERK1 and MAPK1/ERK2, leading to their activation and further transduction of the signal within the MAPK/ERK cascade. Depending on the cellular context, this pathway mediates diverse biological functions such as cell growth, adhesion, survival and differentiation, predominantly through the regulation of transcription, metabolism and cytoskeletal rearrangements. One target of ...
HIPK1 Kinase Enzyme System
Recombinant human HIPK1 (156-555) was expressed in Sf9 cells using an N-terminal GST tag. HIPK1 or homeodomain-interacting protein kinase 1 is a ser/thr protein kinase and a member of the HIPK family.
HEADER TRANSFERASE 31-JAN-08 3C5L TITLE POLO-LIKE KINASE 1 POLO BOX DOMAIN IN COMPLEX WITH PPHSPT TITLE 2 PEPTIDE COMPND MOL_ID: 1; COMPND 2 MOLECULE: SERINE/THREONINE-PROTEIN KINASE PLK1; COMPND 3 CHAIN: A; COMPND 4 FRAGMENT: POLO BOX 1, POLO BOX 2, UNP RESIDUES 373-593; COMPND 5 SYNONYM: POLO-LIKE KINASE 1, PLK-1, SERINE/THREONINE- COMPND 6 PROTEIN KINASE 13, STPK13; COMPND 7 EC: 220.127.116.11; COMPND 8 ENGINEERED: YES; COMPND 9 MOL_ID: 2; COMPND 10 MOLECULE: PEPTIDE; COMPND 11 CHAIN: B; COMPND 12 ENGINEERED: YES SOURCE MOL_ID: 1; SOURCE 2 ORGANISM_SCIENTIFIC: HOMO SAPIENS; SOURCE 3 ORGANISM_COMMON: HUMAN; SOURCE 4 ORGANISM_TAXID: 9606; SOURCE 5 GENE: PLK1, PLK; SOURCE 6 EXPRESSION_SYSTEM: ESCHERICHIA COLI; SOURCE 7 EXPRESSION_SYSTEM_TAXID: 562; SOURCE 8 EXPRESSION_SYSTEM_STRAIN: ROSETTA 2; SOURCE 9 EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID; SOURCE 10 EXPRESSION_SYSTEM_PLASMID: PET28A; SOURCE 11 MOL_ID: 2; SOURCE 12 SYNTHETIC: YES KEYWDS PLK1, POLO-LIKE KINASE 1, POLO BOX DOMAIN, PHOSPHOPEPTIDE, ...
Rac gamma serine threonine protein kinase Worldwide Market Reports
RAC Gamma Serine/Threonine Protein Kinase Market Forecast To 2026 | Covid-19 Impact And Global Analysis By Type, Application, And End User
Serine/threonine-protein kinase PRP4 homolog
Pre-mRNA splicing occurs in two sequential transesterification steps, and the protein encoded by this gene is thought to be involved in pre-mRNA splicing and in signal transduction. This protein belongs to a kinase family that includes serine/arginine-rich protein-specific kinases and cyclin-dependent kinases (CDKs). This protein is regarded as a CDK-like kinase (Clk) with homology to mitogen-activated protein kinases (MAPKs). [provided by RefSeq, Jul 2008 ...
This gene is the human homolog of mouse BMP-2-inducible kinase. Bone morphogenic proteins (BMPs) play a key role in skeletal development and patterning. Expression of the mouse gene is increased during BMP-2 induced differentiation and the gene product is a putative serine/threonine protein kinase containing a nuclear localization signal. Therefore, the protein encoded by this human homolog is thought to be a protein kinase with a putative regulatory role in attenuating the program of osteoblast differentiation. Two transcript variants encoding different isoforms have been found for this gene ...
APExBIO - A-674563|Akt1/PKA/CDK2 inhibitor,potent and selective|CAS# 552325-73-2
A-674563 is a potent and selective Akt1 inhibitor with IC50 value of 14 nM. A-67453 also inhibited PKA and Cdk2 with IC50 value of 16 nM and 46 nM. Akt, also known as protein kinase B, is a serine/threonine-specific protein kinase that plays a key role
STK10 - wikidoc
Serine/threonine-protein kinase 10 is an enzyme that in humans is encoded by the STK10 gene. This gene encodes a member of the Ste20 family of serine/threonine protein kinases, and is similar to several known polo-like kinase kinases. The protein can associate with and phosphorylate polo-like kinase 1, and overexpression of a kinase-dead version of the protein interferes with normal cell cycle progression. The kinase can also negatively regulate interleukin 2 expression in T-cells via the mitogen activated protein kinase kinase 1 pathway. ...
Hippo signaling pathway
The Hippo signaling pathway has emerged as a critical regulator for organ size control. The serine/threonine protein kinases Mst1 and Mst2, mammalian homologs of the Hippo kinase from Drosophila, play the cent... Authors: Funiu Qin, Jing Tian, Dawang Zhou and Lanfen Chen. ...
Search: protein class:NEK Ser/Thr protein kinases AND annotated expression ih:Yes AND ih tissue reliability:Supportive - The...
annotations (the reliablity of the annotated protein expression using immunohistochemically (IH) stained on human tissues, the reliablity of the annotated protein expression in immunofluorescently (IF) stained human cell lines, tissue specificity (the distribution of antibody staining or protein expression in human cell types), cell line specificity (the distribution of RNA abundance in cell lines) and subcellular location (based on immunofluorescent staining of cell lines ...
Search: protein class:CAMK Ser/Thr protein kinases AND annotated expression ih:Yes AND if reliability:Supportive - The Human...
annotations (the reliablity of the annotated protein expression using immunohistochemically (IH) stained on human tissues, the reliablity of the annotated protein expression in immunofluorescently (IF) stained human cell lines, tissue specificity (the distribution of antibody staining or protein expression in human cell types), cell line specificity (the distribution of RNA abundance in cell lines) and subcellular location (based on immunofluorescent staining of cell lines ...
IJMS | Free Full-Text | Comparative Molecular Dynamics Simulations of Mitogen-Activated Protein Kinase-Activated Protein...
The mitogen-activated protein kinase-activated protein kinase MK5 is a substrate of the mitogen-activated protein kinases p38, ERK3 and ERK4. Cell culture and animal studies have demonstrated that MK5 is involved in tumour suppression and promotion, embryogenesis, anxiety, cell motility and cell cycle regulation. In the present study, homology models of MK5 were used for molecular dynamics (MD) simulations of: (1) MK5 alone; (2) MK5 in complex with an inhibitor; and (3) MK5 in complex with the interaction partner p38α. The calculations showed that the inhibitor occupied the active site and disrupted the intramolecular network of amino acids. However, intramolecular interactions consistent with an inactive protein kinase fold were not formed. MD with p38α showed that not only the p38 docking region, but also amino acids in the activation segment, αH helix, P-loop, regulatory phosphorylation region and the C-terminal of MK5 may be involved in forming a very stable MK5-p38α complex, and that p38α
Cyclin-dependent kinase-like kinases (CLKs) are dual specificity protein kinases that phosphorylate | immune-source.com
immune Uncategorized 546141-08-6 IC50, Rabbit polyclonal to annexinA5. Cyclin-dependent kinase-like kinases (CLKs) are dual specificity protein kinases that phosphorylate Serine/Arginine-rich (SR) proteins involved in pre-mRNA processing. cases caused by the tropical disease malaria per annum . During life cycle progression from humans to mosquitoes, switches between stages with high replication rates and ones arrested in their cell cycle and also passes through a phase of sexual reproduction. These rapid transformations require fine-tuned mechanisms of gene expression, and the importance of post-transcriptional regulation of gene expression Rabbit polyclonal to annexinA5 in parasites has previously been highlighted . These include the alternative splicing (AS) of pre-mRNA, enabling the parasite to express functionally different protein isoforms. Two genome-wide studies implied that more than 200 AS events occur during blood stage replication of encodes four members of the CLK family, ...
Munin: Mitogen-activated protein kinase-activated protein kinase 5 - Structure, function and inhibition
Protein kinases have become central in the efforts to understand the nature of various diseases, and a lot is invested into creating effective therapeutic strategies and finding effective and selective protein kinase inhibitors. In order to succeed it is also important to focus on the structure of the kinases, their exact biological role, and how they interact and cooperate in the signaling. The exact structure of MAPKAPK5 is still unknown, and selective inhibitors are yet to be identified. Even though some of its biological roles are starting to emerge more work is required, including searching for selective inhibitors, analyzing its structure and interactions with its interaction partners. In order to analyze the structure of MAPKAPK5, homology models were generated and their ability to discriminate between binders and non-binders were analyzed. Based on the results, one model was found satisfactory and may be used as a working tool for further experimental studies and possibly structure aided ...
Mitogen-activated protein kinase-activated protein kinase 2 (MK2) in skeletal muscle atrophy and hypertrophy
Following denervation skeletal muscles change their functional and structural properties. Some changes resemble conditions in developing muscles and may be important for reinnervation. Due to inactivity following denervation most skeletal muscles loose muscle mass and become atrophic. The hemidiaphragm muscle, however, undergoes a phase of transient hypertrophy following denervation, gaining weight during the first 6-10 days followed by a decrease in weight. In this thesis the expression (mRNA, protein and protein phosphorylations) of potential factors involved in the regulation of muscle mass were examined in denervated hind-limb and hemidiaphragm muscles.. NIFK is a protein that associates with Ki67, a protein expressed predominantly in proliferating cells. The mRNA expression of NIFK was upregulated in denervated atrophic muscles but unaltered in denervated hypertrophic muscles, suggesting a potential role in the regulation of skeletal muscle mass (Paper I). p38 MAPK has previously been ...
Human myotonic dystrophy protein ... preview & related info | Mendeley
(2005) Del Carratore et al. Biochimica et Biophysica Acta - Molecular Cell Research. Human myotonic dystrophy protein kinase (DMPK), the product of the myotonic dystrophy (DM) locus, is a member of a novel class of multidomain serine-threonine protein kinases, which interacts with members of the ...
Metabolic control of regulatory T cell (Treg) survival and function by Lkb1 | Proceedings of the National Academy of Sciences
The metabolic programs of functionally distinct T cell subsets are tailored to their immunologic activities. While quiescent T cells use oxidative phosphorylation (OXPHOS) for energy production, and effector T cells (Teffs) rely on glycolysis for proliferation, the distinct metabolic features of regulatory T cells (Tregs) are less well established. Here we show that the metabolic sensor LKB1 is critical to maintain cellular metabolism and energy homeostasis in Tregs. Treg-specific deletion of Lkb1 in mice causes loss of Treg number and function, leading to a fatal, early-onset autoimmune disorder. Tregs lacking Lkb1 have defective mitochondria, compromised OXPHOS, depleted cellular ATP, and altered cellular metabolism pathways that compromise their survival and function. Furthermore, we demonstrate that the function of LKB1 in Tregs is largely independent of the AMP-activated protein kinase, but is mediated by the MAP/microtubule affinity-regulating kinases and salt-inducible kinases. Our ...
Citron kinase - Wikipedia
Citron is a 183 kDa protein that contains a C6H2 zinc finger, a PH domain, and a long coiled-coil forming region including 4 leucine zippers and a rho / rac binding site. It was discovered as a rho/rac effector in 1995, interacting only with the GTP bound forms of rho and rac 1. Displaying a distinctive protein organization, this protein defines a separate class of rho partners. Using a cloning approach based on the polymerase chain reaction (PCR), a splice variant of citron, citron kinase (citron-K) has been identified with an alternative amino terminus. This N-terminal extension contains a protein kinase domain that has approximately 50% sequence identity to the sequences of ROCK, ROK, myotonic dystrophy protein kinase (MDPK) and the CDC42 effector known as MRCK or GEK. Citron kinase, which resembles the ROCK family of kinases and by comparison to it, is therefore a multiple domain protein containing an N-terminal kinase domain, an internal coiled-coil (CC) domain with Rho/Rac ...
Myotonin-protein kinase - Wikipedia
Myotonin-protein kinase (MT-PK) also known as myotonic dystrophy protein kinase (MDPK) or dystrophia myotonica protein kinase (DMK) is an enzyme that in humans is encoded by the DMPK gene. The dmpk gene product is a Ser/Thr protein kinase homologous to the MRCK p21-activated kinases and the Rho family of kinases. Data obtained by using antibodies that detect specific isoforms of DMPK indicate that the most abundant isoform of DMPK is an 80-kDa protein expressed almost exclusively in smooth, skeletal, and cardiac muscles. This kinase exists both as a membrane-associated and as a soluble form in human left ventricular samples. The different C termini of DMPK that arise from alternative splicing determine its localization to the endoplasmic reticulum, mitochondria, or cytosol in transfected COS-1 cells. Among the substrates for DMPK proposed by in vitro studies are phospholemman, the dihydropyridine receptor, and the myosin phosphatase targeting subunit. However, an in vivo demonstration of the ...
Materials. CEP-1347, also known as KT7515, is a semisynthetic derivative of K-252a provided by Kyowa-Hakko Kogyo (Tokyo, Japan) (Kaneko et al., 1997). CEP-1347 was dissolved in cell culture grade dimethylsulfoxide (DMSO) and stored in the dark at 4°C. All dilutions of CEP-1347 were made in DMEM containing 1% bovine serum albumin. c-Jun N-terminal kinase 1 (JNK1) antibody (catalog #sc-474-G) was purchased from Santa Cruz Biotechnology (Santa Cruz, CA). ERK1 antibody (catalog #06-182), mitogen-activated protein kinase-activated protein kinase 2 (MAPKAP2) antibody (catalog #06-534), and MAPKAP2 peptide substrate (catalog #12-240) were purchased from Upstate Biotechnology (Lake Placid, NY). HA antibody was purchased from Babco (Richmond, CA). AP-1 (c-jun) substrate was purchased from Promega (Madison, WI). Myelin basic protein substrate, Hoechst dye, and tunicamycin were purchased from Sigma (St. Louis, MO). SB203580 was custom-synthesized by RIT International Technology (Snellville, GA). ...
British Library EThOS: The role of salt-inducible kinase in the control of hepatic gluconeogenesis
Regulation of hepatic gluconeogenesis by hormones insulin and glucagon is central to glucose homeostasis. Recent work has proposed that amongst the salt inducible kinase isoforms (SIK1, 2 and 3), members of the AMPK-related kinase family, the SIK2 isoform may play a role as signalling mediator in the control of insulin- and glucagon-regulated hepatic gluconeogenesis. However, the mechanisms of the hormonal-regulation of SIK2 in liver remain controversial, with much of the data based on the studies in non-hepatic tissues/cells. Therefore, the exact molecular regulation of SIK2 by these hormones in the liver required robust and intensive molecular/biochemical research coupled to physiological readout (e.g. gluconeogenesis). My studies with phosphopeptide mapping by mass spectrometry followed by verification with well-characterised phospho-specific antibodies revealed that SIK2 was phosphorylated on Ser343, Ser358, Thr484 and Ser587 in response to glucagon and fasting but not following insulin ...
anti-PRAK antibody [N3C3] | GeneTex
PRAK antibody [N3C3] (mitogen-activated protein kinase-activated protein kinase 5) for ICC/IF, WB. Anti-PRAK pAb (GTX107938) is tested in Human samples. 100% Ab-Assurance.
The Dual-Specificity Kinase DYRK1A Modulates the Levels of Cyclin L2 To Control HIV Replication in Macropha
HIV replication in macrophages contributes to the latent viral reservoirs, which are considered the main barrier to HIV eradication. Few cellular factors that facilitate HIV replication in latently infected cells are known. We previously identified cyclin L2 as a critical factor required by HIV-1 and found that depletion of cyclin L2 attenuates HIV-1 replication in macrophages. Here we demonstrate that cyclin L2 promotes HIV-1 replication through interactions with the dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A). Cyclin L2 and DYRK1A were colocalized in the nucleus and were found together in immunoprecipitation experiments. Knockdown or inhibition of DYRK1A increased HIV-1 replication in macrophages, while depletion of cyclin L2 decreased HIV-1 replication. Furthermore, depletion of DYRK1A increased expression levels of cyclin L2. DYRK1A is a proline-directed kinase that phosphorylates cyclin L2 at serine residues. Mutations of cyclin L2 at serine residues preceding ...
MAP3K10 mitogen-activated protein kinase kinase kinase 10 [Homo sapiens (human)] - Gene - NCBI
The protein encoded by this gene is a member of the serine/threonine kinase family. This kinase has been shown to activate MAPK8/JNK and MKK4/SEK1, and this kinase itself can be phoshorylated, and thus activated by JNK kinases. This kinase functions preferentially on the JNK signaling pathway, and is reported to be involved in nerve growth factor (NGF) induced neuronal apoptosis. [provided by RefSeq, Jul 2008 ...
Serine/threonine kinase 12 | definition of serine/threonine kinase 12 by Medical dictionary
Looking for online definition of serine/threonine kinase 12 in the Medical Dictionary? serine/threonine kinase 12 explanation free. What is serine/threonine kinase 12? Meaning of serine/threonine kinase 12 medical term. What does serine/threonine kinase 12 mean?
Mutation of leucine-rich repeat kinase 2 (LRRK2) causes an autosomal dominant | EGFR Tyrosine Kinase Inhibitors Activate...
Mutation of leucine-rich repeat kinase 2 (LRRK2) causes an autosomal dominant and late-onset familial Parkinsons disease (PD). FAK activation through different mechanisms that are the advertising of autoinhibition and/or the recruitment of phosphatases, such as for example SHP-2. continues to be connected with an autosomal dominant, late-onset type of familial Parkinsons disease (PD). The encoded proteins, LRRK2, is approximately 280 kDa in proportions and contains many useful domains, including a serine/threonine kinase area . Among the PD-related pathogenic mutations discovered throughout the whole gene , the G2019S mutation, which enhances kinase activity , continues to be within both familial and sporadic PD [4,5]. Many reports have sought to recognize the kinase substrates of LRRK2 to boost our knowledge of LRRK2-mediated PD pathogenesis, and LRRK2 provides been proven to govern different biological features, including neurite outgrowth, cell MEK162 inhibitor database migration, ...
AKT2, a putative oncogene encoding a member of a subfamily of protein-serine/threonine kinases, is amplified in human ovarian...
We isolated cDNA clones containing the entire coding region of the putative oncogene AKT2. Sequence analysis and in vitro translation demonstrated that AKT2 encodes a 56-kDa protein with homology to serine/threonine kinases; moreover, this protein contains a Src homology 2-like domain. AKT2 was shown to be amplified and overexpressed in 2 of 8 ovarian carcinoma cell lines and 2 of 15 primary ovarian tumors. AKT2 was mapped to chromosome region 19q13.1-q13.2 by fluorescence in situ hybridization. In the two ovarian carcinoma cell lines exhibiting amplification of AKT2, the amplified sequences were localized within homogeneously staining regions. We conclude that AKT2 belongs to a distinct subfamily of protein-serine/threonine kinases containing Src homology 2-like domains and that alterations of AKT2 may contribute to the pathogenesis of ovarian carcinomas.. ...
MAP2K5 mitogen-activated protein kinase kinase 5 [Homo sapiens (human)] - Gene - NCBI
The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically interacts with and activates MAPK7/ERK5. This kinase itself can be phosphorylated and activated by MAP3K3/MEKK3, as well as by atypical protein kinase C isoforms (aPKCs). The signal cascade mediated by this kinase is involved in growth factor stimulated cell proliferation and muscle cell differentiation. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been described. [provided by RefSeq, May 2011 ...
Raw data for figures from Alsaeedi et al. Expression of serine/threonine protein kinase SGK1F promotes an hepatoblast state in...
Raw data for figures from Alsaeedi et al. Expression of serine/threonine protein kinase SGK1F promotes an hepatoblast state in stem cells directed to differentiate into hepatocytes PLOS ONE 2019 (PLOS2019 data file)
Essential Role of Nuclear Factor (NF)-κB-Inducing Kinase and Inhibitor of κb (Iκb) Kinase α in Nf-κb Activation through...
The transcription factor nuclear factor (NF)-κB plays a pivotal role in the regulation of innate immunity, stress responses, inflammation, and the inhibition of apoptosis 1,2. The activity of NF-κB is tightly regulated by cytokines and other external stimuli. In most cell types, NF-κB is present as a heterodimer comprising 50-kD (p50) and 65-kD (p65) subunits and is sequestered in the cytoplasm by a member of the inhibitor of κB (IκB) family of inhibitory proteins. NF-κB activation requires the degradation of IκB proteins, and the mechanisms of IκB degradation and subsequent NF-κB activation have been the subject of intense investigation 3. Those studies have revealed two important classes of kinase involved in this pathway: mitogen-activated protein kinase kinase kinase (MAP3K) and its downstream target, IκB kinase (IKK) 4,5. NF-κB-inducing kinase (NIK) is structurally related to MAP3K and has been identified as a TNFR-associated factor (TRAF)2-interacting protein 6. On the basis of ...
Experts and Doctors on protein serine threonine kinases in Salt Lake City, Utah, United States
Locale, Genomes and Genes, Scientific Experts, Publications, Research Topics, Species about Experts and Doctors on protein serine threonine kinases in Salt Lake City, Utah, United States
MAPKAPK2 (MK2) | 抑制剂 激动剂 拮抗剂 调节剂 | MCE
MAP kinase-activated protein kinase 2 (MAPKAPK2) is an enzyme that in humans is encoded by the MAPKAPK2 gene. MAPKAP kinase-2 (MK2) is originally identified by its phosphorylation of glycogen synthase at serine-7 and the corresponding serine in a peptide (GS peptide-1) modelled after the N-terminus of glycogen synthase.. MAPKAP kinase-2 is a novel protein kinase activated by mitogen-activated protein kinase. This MAP kinase activated protein kinase, termed MAPKAP kinase-2, is distinguished from S6 kinase-II (MAPKAP kinase-1) by its response to inhibitors, lack of phosphorylation of S6 peptides and amino acid sequence.. ...
The protein kinase DYRK1A phosphorylates the splicing factor SF3b1/SAP155 at Thr434, a novel in vivo phosphorylation site | BMC...
The splicing factor Sf3b is an integral part of U2 snRNP and plays an essential role during spliceosome assembly and recognition of the introns branch point. One of the components of SF3b, SF3b1, is known to be reversibly phosphorylated during splicing catalysis , suggesting that protein kinases play a role in the regulation of splicing. Previous studies have shown that cyclin E/CDK2 complexes associate with spliceosomal proteins in vivo, and that CDK2 phosphorylates SF3b1 in vitro [12, 22]. Here we provide evidence that the protein kinase DYRK1A phosphorylates SF3b1 in vitro and in vivo.. The N-terminal part of Sf3b1 harbours a large number of Thr/Pro dipeptide motifs within a 240-amino acid region preceding the carboxyterminal repeat domain (Fig. 1). Both DYRK1A and CDK2 are proline-directed kinases, i.e. they phosphorylate serine or threonine residues followed by a proline residue [15, 23]. It has been shown that cyclin E/CDK2 phosphorylates SF3b1 in vitro at multiple sites within the ...
Mapkapk5 MGI Mouse Gene Detail - MGI:1333110 - MAP kinase-activated protein kinase 5
View mouse Mapkapk5 Chr5:121525038-121545905 with: phenotypes, sequences, polymorphisms, proteins, references, function, expression
The proliferation of chronic lymphocytic leukemia (CLL) cells requires communication with the lymphoid organ microenvironment. Integrin-linked kinase (ILK) is a multifunctional intracellular adaptor protein that transmits extracellular signals to regulate malignant cell motility, metastasis, and cell cycle progression, but is poorly characterized in hematological malignancies. In this study, we investigated the role of ILK in the context of CLL and observed high ILK expression in patient samples, particularly in tumor cells harboring prognostic high risk markers such as unmutated IGHV genes, high Zap70 or CD38 expression, or a signature of recent proliferation. We also found increased numbers of Ki67 (MKI67)-positive cells in regions of enhanced ILK expression in lymph nodes (LNs) from CLL patients. Using co-culture conditions mimicking the proliferative LN microenvironment, we detected a parallel induction of ILK and cyclin D1 (CCND1) expression in CLL cells that was dependent on the activation ...
NIK is a new Ste20‐related kinase that binds NCK and MEKK1 and activates the SAPK/JNK cascade via a conserved regulatory domain...
We have identified a novel serine/threonine kinase, NIK, that interacts with the SH3 domains of Nck. Overexpression of NIK constitutively activated the JNK/SAPK pathway. NIK interacts with MEKK1 in cells and likely signals through MEKK1 to activate JNK, suggesting that NIK directly regulates MEKK1 activity. We found that NIK contains a regulatory domain in its C‐terminus that is conserved in two other members of this kinase family. This domain mediates the association of NIK with MEKK1 and is critical for NIK activation of the SAPK pathway, suggesting that the C‐terminal domain of these proteins encodes a new protein domain family that couples these kinases to the SAPK pathway, possibly by interacting with MEKK1. Our finding that NIK also interacts with Nck suggests that SH2/SH3 adaptor proteins couple NIK and related kinases to activation of the SAPK/JNK pathway by different receptors.. Studies in Saccharomyces cerevisiae have shown that a serine/threonine kinase, Ste20, acts upstream of ...
LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1<...
TY - JOUR. T1 - LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1. AU - Lizcano, Jose M.. AU - Goransson, Olga. AU - Toth, Rachel. AU - Deak, Maria. AU - Morrice, Nick A.. AU - Boudeau, Jerome. AU - Hawley, Simon. AU - Udd, Lina. AU - Makela, Tomi P.. AU - Hardie, D. Grahame. AU - Alessi, Dario R.. N1 - dc.publisher: Nature Publishing Group PY - 2004/2. Y1 - 2004/2. N2 - We recently demonstrated that the LKB1 tumour suppressor kinase, in complex with the pseudokinase STRAD and the scaffolding protein MO25, phosphorylates and activates AMP-activated protein kinase (AMPK). A total of 12 human kinases (NUAK1, NUAK2, BRSK1, BRSK2, QIK, QSK, SIK, MARK1, MARK2, MARK3, MARK4 and MELK) are related to AMPK. Here we demonstrate that LKB1 can phosphorylate the T-loop of all the members of this subfamily, apart from MELK, increasing their activity ,50-fold. LKB1 catalytic activity and the presence of MO25 and STRAD are required for activation. Mutation of the ...
Targeting 3-phosphoinositide-dependent protein kinase 1 by N-acetyl-cysteine through activation of peroxisome proliferators...
NAC, a common dietary supplement and an antioxidant membrane-permeable metal-binding compound, has been shown to inhibit inflammatory responses, tumor growth including lung cancer [13, 14]. However, the mechanisms by which this reagent in control of NSCLC cell growth has not been well elucidated. We have found that NAC inhibited NSCLC cell proliferation through reduction of PDK1, a kinase and master regulator of a number of downstream signal cascades that are involved in suppression of apoptosis and promotion of tumor growth including lung cancer [4, 15]. High expression of PDK1 has been detected in invasive cancers including lung  and inhibition of PDK1 in several cancer cells results in significant cell growth inhibition . These observations suggest that PDK1 can be considered as a target for therapies. This result, together with the finding that exogenous PDK1 diminishes the inhibitory effect of NAC on cell growth, indicates an important role of targeting PDK1 in mediating the ...
Protein Kinase Functions - Jim Woodgett - Oxford University Press
Since the publication of Protein Kinases in 1994 many novel protein kinases have been discovered, but perhaps more importantly there have been dramatic advances in our understanding of the cellular functions of this remarkably diverse class of proteins. Protein Kinase Functions is not just an update of the previous edition but provides a new focus on the context and function of protein kinases, thus reflecting the recent advances in kinase biology.
Gene Ontology Classifications
Predicted to have cyclin-dependent protein serine/threonine kinase regulator activity. Predicted to be involved in mitotic cell cycle phase transition and regulation of cyclin-dependent protein serine/threonine kinase activity. Predicted to localize to cyclin-dependent protein kinase holoenzyme complex; cytoplasm; and nucleus. Orthologous to human CCNJL (cyclin J like ...
Hipk Antagonizes Hippo | Science Signaling
Signaling through the Hippo-Salvador-Warts (Wts) kinase cascade inhibits cell proliferation and promotes apoptosis by preventing nuclear accumulation of the transcriptional coactivator Yorkie (Yki in the fruit fly) or Yap (in vertebrates). Hippo-dependent phosphorylation of Yki by Wts prevents nuclear accumulation of Yki. In the nucleus, Yki cooperates with its partner Scalloped to promote expression of several target genes that inhibit apoptosis and promote mitosis. Two studies report that the serine-threonine kinase homeodomain-interacting protein kinase (Hipk) promotes Yki activity. Studies by Chen and Verheyen and by Poon et al. both demonstrate that, like overexpresison of yki or knockdown of wts, overexpresison of hipk in fly imaginal discs caused excessive cell proliferation, leading to tissue overgrowth, and stimulation of endogenous Yki transcriptional targets and reporter constructs. Reducing Hipk activity by mutation or RNA interference (RNAi) reduced both tissue size and expression ...
Most recent papers with the keyword hippo pathway | Read by QxMD
The Hippo pathway component WW domain-containing transcription regulator 1 (TAZ) is a transcriptional co-activator and an oncogene in breast and lung cancer. Transcriptional targets of TAZ that modulate immune cell function in the tumour microenvironment are poorly understood. Here, we perform a comprehensive screen for immune-related genes regulated by TAZ and its paralog YAP using NanoString gene expression profiling. We identify the immune checkpoint molecule PD-L1 as a target of Hippo signaling. The upstream kinases of the Hippo pathway, mammalian STE20-like kinase 1 and 2 (MST1/2) and large tumour suppressor 1 and 2 (LATS1/2), suppress PD-L1 expression while TAZ and YAP enhance PD-L1 levels in breast and lung cancer cell lines ...
Renal function of gene-targeted mice lacking both SGK1 and SGK3<...
TY - JOUR. T1 - Renal function of gene-targeted mice lacking both SGK1 and SGK3. AU - Grahammer, Florian. AU - Artunc, Ferruh. AU - Sandulache, Diana. AU - Rexhepaj, Rexhep. AU - Friedrich, Björn. AU - Risler, Teut. AU - McCormick, James A.. AU - Dawson, Kevin. AU - Wang, Jian. AU - Pearce, David. AU - Wulff, Peer. AU - Kuhl, Dietmar. AU - Lang, Florian. PY - 2006/4. Y1 - 2006/4. N2 - Serum- and glucocorticoid-inducible kinase (SGK) 1 and SGK3 share the ability to upregulate several ion channels, including the epithelial Na + channel. Whereas SGK1 is under genomic control of mineralocorticoids and glucocorticoids, SGK3 is constitutively expressed. The SKG1-knockout (sgk1-/-) mouse is seemingly normal when it is fed a standard diet, but its ability to retain NaCl is impaired when it is fed a salt-deficient diet. In the SGK3-knockout (sgk3-/-) mouse fed standard and salt-deficient diets, hair growth is strikingly delayed but NaCl excretion is normal. Thus the possibility was considered that SGK1 ...
Dr Josep Font Sadurni - The University of Sydney
Zhou, Q., Phoa, A., Abbassi, R., Hoque, M., Reekie, T., Font Sadurni, J., Ryan, R., Stringer, B., Day, B., Johns, T., Munoz, L., Kassiou, M. (2017). Structural optimization and pharmacological evaluation of inhibitors targeting dual-specificity tyrosine phosphorylation-regulated kinases (DYRK) and CDC-like kinases (CLK) inglioblastoma. Journal of Medicinal Chemistry, 60(5), 2052-2070. [More Information] ...
Nerliens - Cellesignalisering - ADP-Glo Kinase Assay + DNA-PK Kinase
Native human DNA-Dependent Protein Kinase (DNA-PK) purified from HeLa cells. DNA-PK consists of an approximately 460kDa catalytic subunit and a heterodimeric DNA-binding subunit (Ku) containing an 85kDa and an 70kDa peptide (1). The gene sequence can be found at accession number NM_006904. ADP-Glo Kinase Assay is a luminescent kinase assay that measures ADP formed from a kinase reaction; ADP is converted into ATP, which is a substrate in a reaction catalyzed by Ultra-Glo Luciferase that produces light. The luminescent signal positively correlates with ADP amount and kinase activity. The assay is well suited for measuring the effects chemical compounds have on the activity of a broad range of purified kinases, making it ideal for both primary screening as well as kinase selectivity profiling. The ADP-Glo Kinase Assay can be used to monitor the activity of virtually any ADP-generating enzyme (e.g., kinase or ATPase) using up to 1mM ATP. Kinase Enzyme System contains: Kinase: DNA-PK, 2,500 units ...
Inhibition of polo-like kinase 1 by blocking polo-box domain-dependent protein-protein interactions. - Semantic Scholar
The serine/threonine kinase Polo-like kinase 1 (Plk1) is overexpressed in many types of human cancers, and has been implicated as an adverse prognostic marker for cancer patients. Plk1 localizes to its intracellular anchoring sites via its polo-box domain (PBD). Here we show that Plk1 can be inhibited by small molecules which interfere with its intracellular localization by inhibiting the function of the PBD. We report the natural product thymoquinone and, especially, the synthetic thymoquinone derivative Poloxin as inhibitors of the Plk1 PBD. Both compounds inhibit the function of the Plk1 PBD in vitro, and cause Plk1 mislocalization, chromosome congression defects, mitotic arrest, and apoptosis in HeLa cells. Our data validate the Plk1 PBD as an anticancer target and provide a rationale for developing thymoquinone derivatives as anticancer drugs.
Helicoverpa zea nudivirus 2
Hz2V110 is homologous to serine/threonine protein kinase (S_TPK). S_TPK catalyzes phosphorylation of serine and threonine ... Edelman AM, Blumenthal DK, Krebs EG (June 1987). "Protein serine/threonine kinases". Annual Review of Biochemistry. 56 (1): 567 ... "Choristoneura fumiferana Granulovirus p74 protein, a highly conserved baculoviral envelope protein". Journal of Biochemistry ... Of the 113 ORFs that are likely to encode proteins, 66 are on the forward strand of DNA, the other 47 on the reverse. All of ...
... belongs to the serine/threonine-specific protein kinase family and therefore has the protein kinase domain in positions ... Serine/threonine-protein kinase RIO1 is an enzyme that in humans is encode by the RIOK1 gene. RIOK1 is an atypical protein, ... "Serine/threonine-protein kinase RIO1". Target Report Card. Hinxton, Cambridgeshire, CB10 1SD, UK: EMBL-EBI, Wellcome Genome ... It belongs to the serine/threonine-specific protein kinase family. It has been intensely studied to understand the maturation ...
Serine-threonine kinase receptor-associated protein is an enzyme that in humans is encoded by the STRAP gene. STRAP has been ... "Entrez Gene: STRAP serine/threonine kinase receptor associated protein". Datta PK, Moses HL (May 2000). "STRAP and Smad7 ... signaling and PDK1 kinase activity by physical interaction between PDK1 and serine-threonine kinase receptor-associated protein ... "NM23-H1 tumor suppressor physically interacts with serine-threonine kinase receptor-associated protein, a transforming growth ...
"Regulation of glycolysis by Raf protein serine/threonine kinases". Advances in Enzyme Regulation. 42: 317-32. doi:10.1016/S0065 ... Gupta V, Bamezai RN (November 2010). "Human pyruvate kinase M2: a multifunctional protein". Protein Science. 19 (11): 2031-44. ... Pyruvate kinase isozymes M1/M2 (PKM1/M2), also known as pyruvate kinase muscle isozyme (PKM), pyruvate kinase type K, cytosolic ... "Use of a novel method to find substrates of protein kinase C delta identifies M2 pyruvate kinase". The International Journal of ...
TGF beta signaling pathway
"Phosphorylation of Smad signaling proteins by receptor serine/threonine kinases". Protein Kinase Protocols. Methods in ... It lacks an intracellular serine/threonine protein kinase domain and hence is a pseudoreceptor. It binds to the type I receptor ... These receptors are serine/threonine kinase receptors. They have a cysteine rich extracellular domain, a transmembrane domain ... The type II receptor is a serine/threonine receptor kinase, which catalyzes the phosphorylation of the Type I receptor. Each ...
"Human Mob proteins regulate the NDR1 and NDR2 serine-threonine kinases". J. Biol. Chem. 279 (23): 24444-51. doi:10.1074/jbc. ... "HIV-1 incorporates and proteolytically processes human NDR1 and NDR2 serine-threonine kinases". Virology. 331 (1): 181-9. doi: ... The protein encoded by this gene is a cytoplasmic protein that may play a role in neurite outgrowth. This gene may be involved ... Protein NDRG2 is a protein that in humans is encoded by the NDRG2 gene (NMYC downstream-regulated gene 2). This gene is a ...
"Human Mob proteins regulate the NDR1 and NDR2 serine-threonine kinases". J. Biol. Chem. 279 (23): 24444-51. doi:10.1074/jbc. ... The protein encoded by this gene is similar to the yeast Mob1 protein. Yeast Mob1 binds Mps1p, a protein kinase essential for ... protein kinase by the hMOB1 protein". J. Biol. Chem. 279 (34): 35228-35. doi:10.1074/jbc.M404542200. PMID 15197186. Strausberg ... Mps one binder kinase activator-like 1A, also known as Mob1 homolog 1A, is a protein that in humans is encoded by the MOBKL1A ...
Serine/threonine-protein kinase 38-like is an enzyme that in humans is encoded by the STK38L gene. GRCh38: Ensembl release 89: ... "Human Mob proteins regulate the NDR1 and NDR2 serine-threonine kinases". J. Biol. Chem. 279 (23): 24444-51. doi:10.1074/jbc. ... "Entrez Gene: STK38L serine/threonine kinase 38 like". Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of ... 2004). "Regulation of NDR2 protein kinase by multi-site phosphorylation and the S100B calcium-binding protein". J. Biol. Chem. ...
They signal through receptor tyrosine kinases and serine/threonine protein kinases. Several other biomolecules that have ... Whereas neurotrophic factors within the neurotrophin family commonly have a protein tyrosine kinase receptor (Trk), ... Most NTFs exert their trophic effects on neurons by signaling through tyrosine kinases, usually a receptor tyrosine kinase. In ... The NT-3 protein is found within the thymus, spleen, intestinal epithelium but its role in the function of each organ is still ...
Serine/threonine-protein kinase Sgk2 is an enzyme that in humans is encoded by the SGK2 gene. This gene encodes a serine/ ... threonine protein kinase. Although this gene product is similar to serum- and glucocorticoid-induced protein kinase (SGK), this ... 2003). "The serine/threonine kinases SGK2 and SGK3 are potent stimulators of the epithelial Na+ channel alpha,beta,gamma-ENaC ... 2003). "K+ channel activation by all three isoforms of serum- and glucocorticoid-dependent protein kinase SGK". Pflügers Arch. ...
MAP kinase-interacting serine/threonine-protein kinase 2 is an enzyme that in humans is encoded by the MKNK2 gene. MKNK2 has ... Waskiewicz AJ, Flynn A, Proud CG, Cooper JA (1997). "Mitogen-activated protein kinases activate the serine/threonine kinases ... "Mitogen-activated protein kinases activate the serine/threonine kinases Mnk1 and Mnk2". EMBO J. ENGLAND. 16 (8): 1909-20. doi: ... "Entrez Gene: MKNK2 MAP kinase interacting serine/threonine kinase 2". Scheper, Gert C; Parra Josep L; Wilson Mary; Van ...
"Mitogen-activated protein kinases activate the serine/threonine kinases Mnk1 and Mnk2". EMBO J. 16 (8): 1909-20. doi:10.1093/ ... "Mitogen-activated protein kinase kinase 7 is an activator of the c-Jun NH2-terminal kinase". Proc. Natl. Acad. Sci. U.S.A. 94 ( ... The protein encoded by this gene is a member of the MAP kinase family. MAP kinases, also known as extracellular signal- ... The activation of this kinase requires its phosphorylation by upstream kinases. Upon activation, this kinase translocates to ...
MAP kinase-interacting serine/threonine-protein kinase 1 is an enzyme that in humans is encoded by the MKNK1 gene. MKNK1 has ... Waskiewicz AJ, Flynn A, Proud CG, Cooper JA (1997). "Mitogen-activated protein kinases activate the serine/threonine kinases ... "Mitogen-activated protein kinases activate the serine/threonine kinases Mnk1 and Mnk2". EMBO J. ENGLAND. 16 (8): 1909-20. doi: ... a new MAP kinase-activated protein kinase, isolated by a novel expression screening method for identifying protein kinase ...
Serine/threonine protein kinase MST4, also known as mammalian STE20-like protein kinase 4 (MST-4), is a protein that in humans ... "Entrez Gene: RP6-213H19.1 serine/threonine protein kinase MST4". Goudreault M, D'Ambrosio LM, Kean MJ, Mullin MJ, Larsen BG, ... The protein kinase localizes to the Golgi apparatus and is specifically activated by binding to the Golgi matrix protein GM130 ... which are a subset of the Ste20-like kinases. The encoded protein contains an amino-terminal kinase domain, and a carboxy- ...
TGF beta receptor 1
The encoded protein is a serine/threonine protein kinase. Mutations in this gene have been associated with Loeys-Dietz aortic ... Kawabata M, Chytil A, Moses HL (March 1995). "Cloning of a novel type II serine/threonine kinase receptor through interaction ... Transforming growth factor beta receptor I (activin A receptor type II-like kinase, 53kDa) is a membrane-bound receptor protein ... The protein encoded by this gene forms a heteromeric complex with type II TGF-β receptors when bound to TGF-β, transducing the ...
Serine/threonine-protein kinase PLK4 also known as polo-like kinase 4 is an enzyme that in humans is encoded by the PLK4 gene. ... PLK4 encodes a member of the polo family of serine/threonine protein kinases. The protein localizes to centrioles-complex ... Overview of all the structural information available in the PDB for UniProt: O00444 (Human Serine/threonine-protein kinase PLK4 ... Overview of all the structural information available in the PDB for UniProt: Q64702 (Mouse Serine/threonine-protein kinase PLK4 ...
Sanjo H, Kawai T, Akira S (October 1998). "DRAKs, novel serine/threonine kinases related to death-associated protein kinase ... kinase-related apoptosis-inducing protein kinase family and encodes an autophosphorylated nuclear protein with a protein kinase ... Serine/threonine kinase 17a is a protein that in humans is encoded by the STK17A gene. This gene is a member of the death- ... "Entrez Gene: Serine/threonine kinase 17a". Landa I, Ruiz-Llorente S, Montero-Conde C, Inglada-Pérez L, Schiavi F, Leskelä S, ...
PAK proteins, a family of serine/threonine p21-activated kinases, include PAK1, PAK2, PAK3 and PAK4. These proteins serve as ... "The adaptor protein Nck links receptor tyrosine kinases with the serine-threonine kinase Pak1". The Journal of Biological ... Serine/threonine-protein kinase PAK 1 is an enzyme that in humans is encoded by the PAK1 gene. PAK1 is one of six members of ... Manser E, Leung T, Salihuddin H, Zhao ZS, Lim L (January 1994). "A brain serine/threonine protein kinase activated by Cdc42 and ...
The protein undergoes phosphorylation by a serine/threonine kinase, 90 kDa ribosomal S6 kinase. Interactions of this protein ... "A serine/threonine kinase p90rsk1 phosphorylates the anti-proliferative protein Tob". Genes to Cells. 6 (2): 131-8. doi:10.1046 ... "A serine/threonine kinase p90rsk1 phosphorylates the anti-proliferative protein Tob". Genes to Cells. 6 (2): 131-8. doi:10.1046 ... Protein Tob1 is a protein that in humans is encoded by the TOB1 gene. This gene encodes a member of the tob/btg1 family of anti ...
Rosalind A. Segal
"Regulation of neuronal survival by the serine-threonine protein kinase Akt." Science 275, no. 5300 (1997): 661-665. Ma, Qing, ... Segal defined the motif within Hedgehog proteins critical for binding to proteoglycans, defined the nature of the proteoglycan ...
... is a member of the serine/threonine protein kinase family. The SBK3 protein is known to exhibit transferase activity, ... threonine, and tyrosine residues. O-GlcNAc is predicted to occur at five threonines and one serine. SUMOylation was predicted ... similar to mitogen-activated protein kinase 8 (MAPK8). The 1JC ligand is predicted to interact with the SBK3 protein (97% ... Many of these proteins are associated with a form of kinase activity. According to Mentha, SBK3 interacts with SMAD3, MBD3L2, ...
This method has been used to control a variety of proteins including serine/threonine kinases. Day, R. N.; Davidson, M. W. ( ... Zhou, X. X.; Chung, H. K.; Lam, A. J.; Lin, M. Z. (2012). "Optical Control of Protein Activity by Fluorescent Protein Domains ... It can also be used to track fast dynamics of proteins in cells. Oligomeric forms of Dronpa have been engineered as synthetic ... Dronpa is a reversibly switchable photoactivatable fluorescent protein that is 2.5 times as bright as EGFP. Dronpa gets ...
Cyclin-dependent kinase 4
protein kinase activity. • kinase activity. • protein serine/threonine kinase activity. • cyclin-dependent protein serine/ ... protein binding. • ATP binding. • cyclin binding. • cyclin-dependent protein serine/threonine kinase activity. • macromolecular ... Receptor protein serine/threonine kinase (EC 18.104.22.168). *Bone morphogenetic protein receptors *BMPR1 ... regulation of cyclin-dependent protein serine/threonine kinase activity. • negative regulation of G1/S transition of mitotic ...
kinase activity. • protein serine/threonine kinase activity. • GO:0001948 protein binding. • ATP binding. • Rho GTPase binding ... Receptor protein serine/threonine kinase (EC 22.214.171.124). *Bone morphogenetic protein receptors *BMPR1 ... Dephospho-(reductase kinase) kinase (EC 126.96.36.199). *AMP-activated protein kinase α *PRKAA1 ... "Entrez Gene: CIT citron (rho-interacting, serine/threonine kinase 21)".. *^ a b c Madaule P, Furuyashiki T, Reid T, Ishizaki T ...
Receptor protein serine/threonine kinase (EC 188.8.131.52). *Bone morphogenetic protein receptors *BMPR1 ... Dephospho-(reductase kinase) kinase (EC 184.108.40.206). *AMP-activated protein kinase α *PRKAA1 ... Myosin-heavy-chain kinase (EC 220.127.116.11). *Aurora kinase *Aurora A kinase ... This protein-related article is a stub. You can help Wikipedia by expanding it.. *v ...
protein kinase activity. • protein serine/threonine kinase activity. • protein binding. • ATP binding. • magnesium ion binding ... Receptor protein serine/threonine kinase (EC 18.104.22.168). *Bone morphogenetic protein receptors *BMPR1 ... Microtubule-associated serine/threonine-protein kinase 1 is an enzyme that in humans is encoded by the MAST1 gene. ... Dephospho-(reductase kinase) kinase (EC 22.214.171.124). *AMP-activated protein kinase α *PRKAA1 ...
protein serine/threonine kinase activity. • ATP binding. • kinase activity. • protein binding. Cellular component. • cell ... Receptor protein serine/threonine kinase (EC 126.96.36.199). *Bone morphogenetic protein receptors *BMPR1 ... Serine/threonine-protein kinase 19 is an enzyme that in humans is encoded by the STK19 gene. ... Dephospho-(reductase kinase) kinase (EC 188.8.131.52). *AMP-activated protein kinase α *PRKAA1 ...
Serine/threonine-protein kinase 38 is an enzyme that in humans is encoded by the STK38 gene. GRCh38: Ensembl release 89: ... "Molecular cloning and characterization of a conserved nuclear serine(threonine) protein kinase". Proc Natl Acad Sci U S A. 92 ( ... "Human Mob proteins regulate the NDR1 and NDR2 serine-threonine kinases". J. Biol. Chem. 279 (23): 24444-51. doi:10.1074/jbc. ... "Entrez Gene: STK38 serine/threonine kinase 38". Tripodis N, Mason R, Humphray SJ, et al. (1999). "Physical map of human 6p21.2- ...
... protein tyrosine kinases and protein serine/threonine kinases. Dual-specificity kinases are subclass of the tyrosine kinases.[8 ... Receptor protein serine/threonine kinase (EC 184.108.40.206). *Bone morphogenetic protein receptors *BMPR1 ... which is a family of serine/threonine protein kinases, with a sequence similarity to the family of lipid kinases, PI3Ks. ... which is a serine/threonine-specific protein kinase that belongs to the family of phosphatidylinositol-3 kinase (PI3K) related ...
"Entrez Gene: STK24 serine/threonine kinase 24 (STE20 homolog, yeast)". "STK24 - Serine/threonine-protein kinase 24 - Homo ... Serine/threonine-protein kinase 24 is an enzyme that in humans is encoded by the STK24 gene located in the chromosome 13, band ... functions upstream of the mitogen-activated protein kinase (MAPK) cascade. In mammals, protein kinases related to STE20 can be ... It is also known as Mammalian STE20-like protein kinase 3 (MST-3). The protein is 443 amino acids long and its mass is 49 kDa. ...
A protein kinase drifting around on the outer chloroplast membrane can use ATP to add a phosphate group to the Toc34 protein, ... Serine and threonine (both very common in chloroplast transit sequences-making up 20-30% of the sequence) are often the ... It can be regulated through phosphorylation, but by a different protein kinase than the one that phosphorylates Toc34. Its ... Protein targeting and importEdit. See also: Protein targeting. The movement of so many chloroplast genes to the nucleus means ...
Serine/threonine kinase. *RPS6KA3 *Coffin-Lowry syndrome. *CHEK2 *Li-Fraumeni syndrome 2 ... mitogen-activated protein kinase) cascade that is itself a kinase. RSK2 phosphorylates cellular proteins (including histone H3 ... Mutations in the RPS6KA3 gene can result in expression of an RSK2 protein (ribosomal S6 kinase 2) with reduced or absent kinase ... The protein RSK2 which is encoded by the RPS6KA3 gene is a kinase which phosphorylates some substrates like CREB and histone H3 ...
TANGO6: encoding protein Transport and Golgi organization protein 6 homolog. *TAO2: encoding Serine/threonine-protein kinase ... UNKL: encoding protein RING finger protein unkempt-like. *VAT1L: encoding protein Vesicle amine transport protein 1 homolog (T ... LINC00273 encoding protein Long intergenic non-protein coding RNA 273. *LOC124220: encoding protein Zymogen granule protein 16 ... SHCBP1: encoding protein SHC SH2 domain-binding protein 1. *SLZ1: encoding protein SLX1 structure-specific endonuclease subunit ...
Phosphorylation of H3 at serine 10 (phospho-H3S10). The mitotic kinase aurora B phosphorylates histone H3 at serine 10, ... "Phosphorylation of stem-loop binding protein (SLBP) on two threonines triggers degradation of SLBP, the sole cell cycle- ... Phosphorylation H2B at serine 10/14 (phospho-H2BS10/14). Phosphorylation of H2B at serine 10 (yeast) or serine 14 (mammals) is ... Serine/threonine/tyrosine phosphorylation. Addition of a negatively charged phosphate group can lead to major changes in ...
positive regulation of protein kinase activity. • regulation of cyclin-dependent protein serine/threonine kinase activity. • ... positive regulation of protein serine/threonine kinase activity. • superior olivary nucleus maturation. • positive regulation ... Agarwal-Mawal A, Paudel HK (2001). "Neuronal Cdc2-like protein kinase (Cdk5/p25) is associated with protein phosphatase 1 and ... cyclin-dependent protein kinase 5 activator activity. • lipid binding. Cellular component. • cytoplasm. • cyclin-dependent ...
Brain-derived neurotrophic factor
positive regulation of non-membrane spanning protein tyrosine kinase activity. • transmembrane receptor protein tyrosine kinase ... at serine 460 and threonine 461, increasing its ATPase activity which downregulates GABAA receptor surface expression and ... Tropomyosin receptor kinase B § Agonists. References. *^ a b c GRCh38: Ensembl release 89: ENSG00000176697 - Ensembl, May ... "GABAA receptor trafficking is regulated by protein kinase C(epsilon) and the N-ethylmaleimide-sensitive factor". The Journal of ...
Koštani morfogenetički protein 2
... a new oligomerization mode for serine/threonine kinase receptors". Mol. Biol. Cell 11 (3): 1023-35. PMC 14828. PMID 10712517. ... Koštani morfogenetički protein 2 ili BMP-2 pripada TGF-β superfamiliji proteina. ... Chen D, Zhao M, Mundy GR (December 2004). "Bone morphogenetic proteins". Growth Factors 22 (4): 233-41. PMID 15621726. doi: ... Kawamura C, Kizaki M, Ikeda Y (2003). "Bone morphogenetic protein (BMP)-2 induces apoptosis in human myeloma cells.". Leuk. ...
Tumor necrosis factor alpha
TRAF2 in turn recruits the multicomponent protein kinase IKK, enabling the serine-threonine kinase RIP to activate it. An ... positive regulation of protein complex assembly. • protein kinase B signaling. • positive regulation of cytokine production. • ... regulation of protein phosphorylation. • positive regulation of protein phosphorylation. • positive regulation of MAP kinase ... positive regulation of protein kinase activity. • positive regulation of superoxide dismutase activity. • defense response. • ...
Insulin-like growth factor 2
protein serine/threonine kinase activator activity. • receptor ligand activity. Cellular component. • extracellular region. • ... positive regulation of protein serine/threonine kinase activity. • carbohydrate metabolic process. • regulation of receptor ... cellular protein metabolic process. • insulin receptor signaling pathway. • positive regulation of protein kinase B signaling. ... Binding proteins: IGFBP (1, 2, 3, 4, 5, 6, 7). *Cleavage products/derivatives with unknown target: Glypromate (GPE, (1-3)IGF-1) ...
Aminoacyl tRNA synthetase
McClain WH (November 1993). "Rules that govern tRNA identity in protein synthesis". Journal of Molecular Biology. 234 (2): 257- ... "Phosphorylation of glutamyl-prolyl tRNA synthetase by cyclin-dependent kinase 5 dictates transcript-selective translational ... happen when two amino acids have different properties even if they have similar shapes-as is the case with Valine and Threonine ... For instance, one can start with the gene for a protein that binds a certain sequence of DNA, and, by directing an unnatural ...
protein serine/threonine phosphatase activity. • metal ion binding. • protein binding. • heme binding. • electron carrier ... regulated by Pyruvate dehydrogenase kinase and Pyruvate dehydrogenase phosphatase). to α-ketoglutaric acid. *Glutamate ... Soltys BJ, Gupta RS (2000). "Mitochondrial proteins at unexpected cellular locations: export of proteins from mitochondria from ... protein phosphatase type 2A complex. • mitochondrion. • mitochondrial inner membrane. • respiratory chain. • nucleus. • ...
GTP-binding protein regulators
Other protein kinase. Serine/threonine:. *Casein kinase *1. *2. *eIF-2 kinase *EIF2AK3 ... GTP-binding protein regulators regulate G proteins in several different ways. Small GTPases act as molecular switches in ... and thus requires another class of regulatory proteins to accelerate this activity, the GTPase activating proteins (GAPs). ... GTP-Binding+Protein+Regulators at the US National Library of Medicine Medical Subject Headings (MeSH) ...
cyclin-dependent protein serine/threonine kinase activity. • protein kinase inhibitor activity. • protein kinase binding. • ... protein binding. • cyclin-dependent protein serine/threonine kinase inhibitor activity. • ubiquitin protein ligase binding. • ... negative regulation of cyclin-dependent protein serine/threonine kinase activity. • stress-induced premature senescence. • ... regulation of cyclin-dependent protein serine/threonine kinase activity. • DNA damage response, signal transduction by p53 ...
GAD67 is phosphorylated at threonine 91 by protein kinase A (PKA), while GAD65 is phosphorylated, and therefore regulated by, ... L-Serine-O-sulphate (SOS). *L-trans-2,4-PDC. *MPDC. *Maslinic acid ... protein kinase C (PKC). Both GAD67 and GAD65 are also regulated post-translationally by Pyridoxal 5'-phosphate (PLP); GAD is ... In order to aid in neurotransmission, GAD65 forms a complex with Heat Shock Cognate 70 (HSC70), cysteine string protein (CSP) ...
Serine/threonine kinase. *RPS6KA3 *Coffin-Lowry syndrome. *CHEK2 *Li-Fraumeni syndrome 2 ... Deficiencies of intracellular signaling peptides and proteins. GTP-binding protein regulators. GTPase-activating protein. * ...
DAG activates another enzyme called protein kinase C (PKC), and IP3 triggers the release of calcium from intracellular stores. ... and an intracellular C-terminus containing serine and threonine residues important for receptor regulation. The first two ... All of these proteins exert their biological effects by interacting with G protein-linked transmembrane receptors called ... Chemokine receptors associate with G-proteins to transmit cell signals following ligand binding. Activation of G proteins, by ...
Ataxia telangiectasia mutated kinase (ATM kinase). ATM kinase, a member of the PI3-like family of serine/threonine ... Src kinases. The Src-family kinases are examples of proteins that utilize autophosphorylation to sustain their activated ... Kinases are either phosphorylated on serine and/or threonine residues, or solely on tyrosine residues. This serves as a ... a b c d e f g h i j k l m Petsko, GA and Ringe, D 2009, 'Protein Structure and Function', Oxford University Press Inc., New ...
Kromosomang 19 (tao), ang malayang ensiklopedya
STK11: Serine/threonine kinase 11 (Peutz-Jeghers syndrome). Mga sakit at diperensiya[baguhin , baguhin ang batayan]. Ang mga ... DMPK: Dystrophia myotonica-protein kinase. *EYCL1: EYE COLOR 1; EYE COLOR, GREEN/BLUE; GEY. Gene map locus 19p13.1-q13.11 ... Ang pagsisikwensiya ng kromosomang 19 ay pangangasiwaan ni Propesor György Marko-Varga ng Clinical Protein Science & Imaging ... i-sekwensiya ang kabuuang proteome ng tao batay sa mga pagsulong sa masang spektrometriya at magtayo ng pandaigdigang protein ...
Programmed cell death
Three related serine/threonine kinases, UNC-51-like kinase -1, -2, and -3 (ULK1, ULK2, UKL3), which play a similar role as the ... and the scaffold protein FIP200. Class III PI3K complex, containing hVps34, Beclin-1, p150 and Atg14-like protein or ... It has also been shown that in mice null for the proapoptotic factor Bax (Bcl-2-associated X protein) a larger percentage of ... Research on the corn poppy (Papaver rhoeas) has revealed that proteins in the pistil on which the pollen lands, interact with ...
... the G-protein subunit Gα directly activates an enzyme called protein tyrosine kinase (PTK), which phosphorylates serine and ... and an intracellular C-terminus containing serine and threonine residues that act as phosphorylation sites during receptor ... When the molecule GDP is bound to the G-protein subunit, the G-protein is in an inactive state. Following binding of the ... Further information: G protein. Intracellular signaling by chemokine receptors is dependent on neighbouring G-proteins. G- ...
protein kinase activator activity. • 1-phosphatidylinositol-4-phosphate 3-kinase activity. • protein serine/threonine kinase ... 3-kinase and PI 4-kinase binding to the CD4-p56lck complex: the p56lck SH3 domain binds to PI 3-kinase but not PI 4-kinase". ... G-protein coupled receptor signaling pathway. • positive regulation of protein kinase B signaling. • phosphatidylinositol 3- ... 1-phosphatidylinositol-3-kinase activity. • phosphatidylinositol-4,5-bisphosphate 3-kinase activity. • kinase activity. • ...
... element-binding protein through a phosphatidylinositol 3-kinase-dependent stimulation of the mitogen-activated protein kinase ... GluA1 has four known phosphorylation sites at serine 818 (S818), S831, threonine 840, and S845 (other subunits have similar ... "Calcium/calmodulin-dependent protein kinase II phosphorylation drives synapse-associated protein 97 into spines". J. Biol. Chem ... Transmembrane AMPA receptor regulatory proteins (TARPs) are a family proteins that associate with AMPA receptors and control ...
... and a largely basic region between the DIX and PDZ domains that has conserved serine and threonine residues. These regions ... This region mediates many protein-protein interactions and regulates multiple biological processes. ... Activating the Rac GTPase stimulates the downstream effector c-Jun N-terminal kinase (JNK), which controls rearrangements in ... This protein-related article is a stub. You can help Wikipedia by expanding it.. *v ...
Serin/treonin-specifična proteinska kinaza
"Frequent alterations in the expression of serine/threonine kinases in human cancers". Cancer Research 66 (16): 8147-54. PMID ... Protein kinaza C (EC 220.127.116.11). Protein kinaza C, Protein kinaza Cζ, PKC alfa, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCG, PRKCI, ... Receptor protein serin/treonin kinaza (EC 18.104.22.168). Koštani morfogenetski proteinski receptori (BMPR1, BMPR1A, BMPR1B, BMPR2 ... Više od 125 od 500+ poznatih ljudskih protein kinaza su serin/treonin kinaze (STK). ...
cyclin-dependent protein serine/threonine kinase inhibitor activity. • protein binding. • cyclin-dependent protein kinase ... regulation of cyclin-dependent protein serine/threonine kinase activity. • G1/S transition of mitotic cell cycle. • G2/M ... negative regulation of cyclin-dependent protein serine/threonine kinase activity. • response to arsenic-containing substance. • ... protein complex binding. • metal ion binding. Cellular component. • cyclin-dependent protein kinase holoenzyme complex. • ...
protein binding. • hydrolase activity. • protein kinase binding. • serine hydrolase activity. Cellular component. • cytoplasm. ... Protein phosphatase: Protein tyrosine phosphatase. *Protein serine/threonine phosphatase. *Dual-specificity phosphatase ... Also, it may be activated by a cAMP-dependent protein kinase (PKA). This pathway is significantly less effective than the first ... protein phosphorylation. • long-chain fatty acid catabolic process. • metabolism. • triglyceride catabolic process. ...
... is now possible due to in-vitro mutations that are related to serine/threonine kinase and phosphatase. ... Activated protein kinase C inhibits the tyrosine kinase activity of epidermal growth factor receptor (EGFR), the rational ... "Regulation of hemolysin expression and virulence of Staphylococcus aureus by a serine/threonine kinase and phosphatase". PLOS ... TDH induces Ca2+ influx from an extracellular environment accompanied by protein kinase C phosphorylation. ...
Class II PI 3-kinases
2.7.11: protein-serine/threonine. *see serine/threonine-specific protein kinases. 2.7.12: protein-dual-specificity. *see serine ... Class II PI 3-kinases are a subgroup of the enzyme family, phosphoinositide 3-kinase that share a common protein domain ... Phosphoinositide 3-kinase. References. *Stein RC( 2001) Prospects for phosphoinositide 3-kinase inhibition as a cancer ... Class II PI 3-kinases were the most recently identified class of PI 3-kinases and little is currently known about these enzymes ...
Other protein kinase. Serine/threonine:. *Casein kinase *1. *2. *eIF-2 kinase *EIF2AK3 ... protein complex binding. • signal transducer activity. • protein binding. • GTPase activity. • GTPase binding. • G-protein ... 1omw: Crystal Structure of the complex between G Protein-Coupled Receptor Kinase 2 and Heterotrimeric G Protein beta 1 and ... protein heterotrimerization. • Wnt signaling pathway, calcium modulating pathway. • protein folding. • G-protein coupled ...
Serine/threonine-specific protein kinase - Wikipedia
A serine/threonine protein kinase (EC 22.214.171.124) is a kinase enzyme that phosphorylates the OH group of serine or threonine ( ... Serine/threonine-specific protein kinase. From Wikipedia, the free encyclopedia. (Redirected from Non-specific serine/threonine ... specifically protein-serine/threonine kinases. These enzymes transfer phosphates to the oxygen atom of a serine or threonine ... Serine/threonine protein kinase p90-kDa ribosomal S6 kinase (RSK) is in involved in development of some prostate cancers. ...
Serine/Threonine-Protein Kinase SMG1 | SpringerLink
Lambda/iota protein kinase C-interacting protein; Lambda-interacting protein; LIP; Phosphatidylinositol 3-kinase-related kinase ... Phosphatidylinositol 3-kinase-related kinase; Phosphatidylinositol 3-kinase-related protein kinase; PI-3-kinase-related kinase ... 61E3.4; ATX; hSMG-1; KIAA0421; Lambda/iota protein kinase C-interacting protein; Lambda-interacting protein; LIP; ... Yamashita A. (2018) Serine/Threonine-Protein Kinase SMG1. In: Choi S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham ...
Serine/threonine-protein kinase Rio3 (IPR017406) | InterPro | EMBL-EBI
We combine protein signatures from a number of member databases into a single searchable resource, capitalising on their ... InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites ... GO:0006468 protein phosphorylation Molecular Function. GO:0005524 ATP binding GO:0004674 protein serine/threonine kinase ... This entry represents serine/threonine-protein kinases (EC:126.96.36.199) such as Rio3. RIO kinases are atypical members of the ...
Serine/threonine-protein kinase STK11 (Q15831) | InterPro | EMBL-EBI
Eukaryotic phytochromes: Light-regulated serine/threonine protein kinases with histidine kinase ancestry | PNAS
Eukaryotic phytochromes: Light-regulated serine/threonine protein kinases with histidine kinase ancestry. Kuo-Chen Yeh and J. ... Eukaryotic phytochromes: Light-regulated serine/threonine protein kinases with histidine kinase ancestry ... Eukaryotic phytochromes: Light-regulated serine/threonine protein kinases with histidine kinase ancestry ... Eukaryotic phytochromes: Light-regulated serine/threonine protein kinases with histidine kinase ancestry ...
Synpcc7942 0600 serine/threonine protein kinase [Synechococcus elongatus PCC 7942] - Gene - NCBI
serine/threonine protein kinase. Locus tag. Synpcc7942_0600. Gene type. protein coding. RefSeq status. PROVISIONAL. Organism. ... mRNA and Protein(s) * YP_399619.1 serine/threonine protein kinase [Synechococcus elongatus PCC 7942] ... Synpcc7942_0600 serine/threonine protein kinase [ Synechococcus elongatus PCC 7942 ] Gene ID: 3775318, discontinued on 5-Feb- ... General protein information Go to the top of the page Help Names. serine/threonine protein kinase. ...
Anti-Serine/threonine-protein kinase 4 antibody (ab97399)
Rabbit polyclonal Serine/threonine-protein kinase 4 antibody validated for WB, IHC, ICC/IF and tested in Human. Referenced in 1 ... Anti-Serine/threonine-protein kinase 4 antibody. See all Serine/threonine-protein kinase 4 primary antibodies. ... Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.. Contains 1 protein kinase ... Anti-Serine/threonine-protein kinase 4 antibody (ab97399) at 1/1000 dilution + HepG2 whole cell lysate at 30 µg. Predicted band ...
RCSB PDB - Protein Feature View - Serine/threonine-protein kinase 3 - Q13188 (STK3 HUMAN)
The PDB archive contains information about experimentally-determined structures of proteins, nucleic acids, and complex ... This protein in other organisms (by gene name): Q13188 - Homo sapiens 9 * A8K722 - Homo sapiens no matching PDB entries ... in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, ... Protein disorder predictions are based on JRONN (Troshin, P. and Barton, G. J. unpublished), a Java implementation of RONN * ...
RCSB PDB - Protein Feature View - Serine/threonine-protein kinase Sgk1 - O00141 (SGK1 HUMAN)
The PDB archive contains information about experimentally-determined structures of proteins, nucleic acids, and complex ... Serine/threonine-protein kinase which is involved in the regulation of a wide variety of ion channels, membrane transporters, ... ATP + L-threonyl-[protein] = ADP + H+ + O-phospho-L-threonyl-[protein] UniProt ... This protein in other organisms (by gene name): O00141 - Homo sapiens 3 * Q9UN56 - Homo sapiens no matching PDB entries ...
Serine/threonine protein kinase UL97 - DrugBank
Targeting oncogenic serine/threonine-protein kinase BRAF in cancer cells inhibits angiogenesis and abrogates hypoxia | PNAS
Targeting oncogenic serine/threonine-protein kinase BRAF in cancer cells inhibits angiogenesis and abrogates hypoxia. Alessia ... Targeting oncogenic serine/threonine-protein kinase BRAF in cancer cells inhibits angiogenesis and abrogates hypoxia ... Targeting oncogenic serine/threonine-protein kinase BRAF in cancer cells inhibits angiogenesis and abrogates hypoxia ... Targeting oncogenic serine/threonine-protein kinase BRAF in cancer cells inhibits angiogenesis and abrogates hypoxia ...
Bmpr2 bone morphogenetic protein receptor, type II (serine/threonine kinase) [Mus musculus (house mouse)] - Gene - NCBI
... serine/threonine kinase) [Mu... Bmpr2 bone morphogenetic protein receptor, type II (serine/threonine kinase) [Mus musculus]. ... S_TKc; Serine/Threonine protein kinases, catalytic domain. cd14054. Location:207 → 504. STKc_BMPR2_AMHR2; Catalytic domain of ... S_TKc; Serine/Threonine protein kinases, catalytic domain. cd14054. Location:207 → 504. STKc_BMPR2_AMHR2; Catalytic domain of ... bone morphogenetic protein receptor, type II (serine/threonine kinase)provided by MGI. Primary source. MGI:MGI:1095407 See ...
RAC-beta serine/threonine-protein kinase - DrugBank
Protein serine/threonine kinase activity. Specific Function. AKT2 is one of 3 closely related serine/threonine-protein kinases ... lcl,BSEQ0002331,RAC-beta serine/threonine-protein kinase MNEVSVIKEGWLHKRGEYIKTWRPRYFLLKSDGSFIGYKERPEAPDQTLPPLNNFSVAEC ... a putative oncogene encoding a member of a subfamily of protein-serine/threonine kinases, is amplified in human ovarian ... Activation of protein kinase B beta and gamma isoforms by insulin in vivo and by 3-phosphoinositide-dependent protein kinase-1 ...
Nek7 - Serine/threonine-protein kinase Nek7 - Mus musculus (Mouse) - Nek7 gene & protein
Protein kinase which plays an important role in mitotic cell cycle progression. Required for microtubule nucleation activity of ... View protein in PROSITE. PS00107, PROTEIN_KINASE_ATP, 1 hit. PS50011, PROTEIN_KINASE_DOM, 1 hit. PS00108, PROTEIN_KINASE_ ... View protein in PROSITE. PS00107, PROTEIN_KINASE_ATP, 1 hit. PS50011, PROTEIN_KINASE_DOM, 1 hit. PS00108, PROTEIN_KINASE_ ... Serine/threonine-protein kinase Nek7 (EC:188.8.131.52*Search proteins in UniProtKB for this EC number. ...
Haspin - Serine/threonine-protein kinase haspin - Mus musculus (Mouse) - Haspin gene & protein
Serine/threonine-protein kinase that phosphorylates histone H3 at Thr-3 (H3T3ph) during mitosis. May act through H3T3ph to ... protein kinase activity Source: MGI. *protein serine/threonine kinase activity Source: UniProtKBInferred from direct assayi*. ... Serine/threonine-protein kinase haspin (EC:184.108.40.206*Search proteins in UniProtKB for this EC number. ... View protein in InterPro. IPR011009, Kinase-like_dom_sf. IPR000719, Prot_kinase_dom. IPR017441, Protein_kinase_ATP_BS. ...
Anti-Serine/threonine-protein kinase 4 antibody [EP1465Y] (ab51134) Protocols
Protein-Serine-Threonine Kinases | Infection and Immunity
Protein Serine/Threonine Kinase StkP Positively Controls Virulence and Competence in Streptococcus pneumoniae Jose Echenique, ... Identification of Two Eukaryote-Like Serine/Threonine Kinases Encoded by Chlamydia trachomatis Serovar L2 and Characterization ... Phosphoinositide 3 Kinase Mediates Toll-Like Receptor 4-Induced Activation of NF-κB in Endothelial Cells Xianwu Li, Joan C. ... Modulation of Myosin Light-Chain Phosphorylation by p21-Activated Kinase 1 in Escherichia coli Invasion of Human Brain ...
Serine/threonine-protein kinase NIM1 Research Products: Novus Biologicals
Browse our Serine/threonine-protein kinase NIM1 product catalog backed by our Guarantee+. ... Serine/threonine-protein kinase NIM1 products available through Novus Biologicals. ... Protein Kinase. PTMs for Serine/threonine-protein kinase NIM1. Learn more about PTMs related to Serine/threonine-protein kinase ... Diseases related to Serine/threonine-protein kinase NIM1. Discover more about diseases related to Serine/threonine-protein ...
NIM1K (NIM1 serine/threonine protein kinase) - Rat Genome Database
... protein serine/threonine kinase activity; INVOLVED IN protein phosphorylation; INTERACTS WITH 17beta-estradiol; benzo[a]pyrene ... ENCODES a protein that exhibits ATP binding; magnesium ion binding; ... protein serine/threonine kinase activity IDA. 2290271. UniProtKB. PMID:15733851. protein serine/threonine kinase activity IBA. ... Nim1k (NIM1 serine/threonine protein kinase). NCBI. Ortholog. Sus scrofa (pig):. NIM1K (NIM1 serine/threonine protein kinase). ...
CSNK1G1 - Non-specific serine/threonine protein kinase - Physeter macrocephalus (Sperm whale) - CSNK1G1 gene & protein
View protein in PROSITE. PS00107, PROTEIN_KINASE_ATP, 1 hit. PS50011, PROTEIN_KINASE_DOM, 1 hit. PS00108, PROTEIN_KINASE_ ... View protein in PROSITE. PS00107, PROTEIN_KINASE_ATP, 1 hit. PS50011, PROTEIN_KINASE_DOM, 1 hit. PS00108, PROTEIN_KINASE_ ... Kinase, Serine/threonine-protein kinaseUniRule annotation. Automatic assertion according to rulesi ... IPR011009, Kinase-like_dom_sf. IPR000719, Prot_kinase_dom. IPR017441, Protein_kinase_ATP_BS. IPR008271, Ser/Thr_kinase_AS. ...
Serine/threonine-Protein Kinase MST4 (MST4) Antibodies
... mammalian STE20-like protein kinase 4 , serine/threonine protein kinase MST4 , serine/threonine-protein kinase MST4 , mammalian ... anti-Serine/threonine-Protein Kinase PRP4 Homolog Antibodies * anti-Serine/threonine-Protein Phosphatase 4 Regulatory Subunit ... anti-Serine/threonine Protein Phosphatase Ppa2 Antibodies * anti-Serine/threonine Kinase Receptor Associated Protein Antibodies ... Serine/threonine-Protein Kinase MST4 (MST4) Antigen Profile Protein Summary The product of this gene is a member of the GCK ...
Serine/Threonine Protein Kinase Pim 1 - Pipeline Review, H2 2020
Serine/Threonine Protein Kinase Pim 1 (Oncogene PIM1 or PIM1 or EC 220.127.116.11) - Overview. Serine/Threonine Protein Kinase Pim 1 ... Serine/Threonine Protein Kinase Pim 1 (Oncogene PIM1 or PIM1 or EC 18.104.22.168) - Proto-oncogene serine/threonine-protein kinase ... Serine/Threonine Protein Kinase Pim 1 (Oncogene PIM1 or PIM1 or EC 22.214.171.124) - Discontinued Products. Serine/Threonine Protein ... SerineThreonine Protein Kinase Pim 1 - Pipeline Review, H2 2020; Serine/Threonine Protein Kinase Pim 1 (Oncogene PIM1 or PIM1 ...
LOC103691558 (serine/threonine-protein kinase DCLK1-like) - Rat Genome Database
serine/threonine-protein kinase DCLK1-like Symbol and Name status set to provisional. 70820. PROVISIONAL. ... total urine protein amount (VT:0000032). urine protein excretion rate (CMO:0000759). 2. 115721880. 154182196. Rat. ... GenBank Protein. EDM14902. (Get FASTA). NCBI Sequence Viewer Reference Sequences. RefSeq Acc Id:. XP_008773371 ⟸ XM_ ... Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) RatMine GViewer ( ...
pknA - Serine/threonine-protein kinase PknA - Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) - pknA gene & protein
... cell shape and cell division via phosphorylation of target proteins such as FtsZ, Wag31, GlmU, FhaB, PstP, EmbR and Rv1422 ( ... Protein kinase that regulates many aspects of mycobacterial physiology, and is critical for growth in vitro and survival of the ... Transmembrane serine/threonine-protein kinase a PknA (Protein kinase a) (STPK A). MYCTX ... Transmembrane serine/threonine-protein kinase a PknA (Protein kinase a) (STPK A). MYCTX ...
A Salmonella type III secretion effector interacts with the mammalian serine/threonine protein kinase PKN1
... which mediates the transfer of bacterial effector proteins from the bacterial cell into the host cell cytoplasm. Once inside ... It yielded a serine/threonine protein kinase called protein kinase N 1 (PKN1). The leucine-rich repeat domain of SspH1 was ... A Salmonella type III secretion effector interacts with the mammalian serine/threonine protein kinase PKN1 Cell Microbiol. 2006 ... Protein-Serine-Threonine Kinases / biosynthesis * Protein-Serine-Threonine Kinases / metabolism* * Protein-Tyrosine Kinases / ...
non-receptor serine/threonine protein kinase Antibodies | Invitrogen ...
Serine Threonine Protein Kinase ATR, Pipeline Review, H2 2019 - Artios Pharma Ltd, Bayer AG, IMPACT Therapeutics Inc & Pfizer...
Serine Threonine Protein Kinase ATR - Pipeline Review, H2 2019; Serine/Threonine Protein Kinase ATR (Ataxia Telangiectasia And ... Serine/Threonine Protein Kinase ATR (Ataxia Telangiectasia And Rad3 Related Protein or FRAP Related Protein 1 or ATR or EC 2.7. ... Serine/Threonine Protein Kinase ATR (Ataxia Telangiectasia And Rad3 Related Protein or FRAP Related Protein 1 or ATR or EC 2.7. ... Serine/Threonine Protein Kinase ATR (Ataxia Telangiectasia And Rad3 Related Protein or FRAP Related Protein 1 or ATR or EC 2.7. ...
Bacillus subtilis serine/threonine protein kinase YabT is involved in spore development via phosphorylation of a bacterial...
Bacillus subtilis serine/threonine protein kinase YabT is involved in spore development via phosphorylation of a bacterial ... Bacillus subtilis serine/threonine protein kinase YabT is involved in spore development via phosphorylation of a bacterial ... Gaidenko, T.A., Kim, T.J., and Price, C.W. (2002) The PrpC serine-threonine phosphatase and PrkC kinase have opposing ... Pereira, S.F., Goss, L., and Dworkin, J. (2011) Eukaryote-like serine/threonine kinases and phosphatases in bacteria. Microbiol ...
Mitotic Checkpoint Serine/Threonine Protein Kinase (Bub) Research Areas: R&D Systems
... research area related information and Mitotic Checkpoint Serine/Threonine Protein Kinase (Bub) research products from R&D ... Find Mitotic Checkpoint Serine/Threonine Protein Kinase (Bub) ... Mitotic Checkpoint Serine/Threonine Protein Kinase (Bub). The ... Bub1 protein is a serine/threonine kinase that acts in the mitotic spindle checkpoint by recruiting components and promoting ...
DAPK1 (Death-associated protein kinase) and ZIPK (Zipper-interactering protein kinase) - Serine/Threonine Kinase Inhibitors |...
Death-associated protein kinase) and ZIPK (Zipper-interactering protein kinase) ... Serine/Threonine Kinase Biology > Serine/Threonine Kinase Inhibitors > DAPK1 (Death-associated protein kinase) and ZIPK (Zipper ... USA Home > Product Directory > Cell Biology > Cell Signaling and Neuroscience > Kinase/Phosphatase Biology > ...
- In the nucleus accumbens (NAcc), the protein serine/threonine kinase cyclin-dependent kinase 5 (Cdk5) and its phosphorylation target, the guanine-nucleotide exchange factor kalirin-7 (Kal7), may contribute to the neuroadaptations underlying the formation of conditioned associations. (nih.gov)
- In vivo activation of TAK1 requires association with TAK1 binding protein 1 (TAB1), which triggers phosphorylation of TAK1. (abbkine.com)
- This entry represents receptor-interacting serine/threonine-protein kinase 2 (RIP2), which functions in the phosphorylation () of its protein target. (doe.gov)
- PLK (polo-like kinase), which belongs to a family of serine/threonine kinases and represents the human counterpart of structurally related protein kinases, polo of Drosophila melanogaster and CDC5 of Saccharomyces cerevisiae, may be implicated in spindle formation and chromosome segregation during mitosis. (elsevier.com)
- Autophagy is an intracellular catabolic mechanism whereby a cell recycles or degrades damaged proteins and cytoplasmic organelles. (rug.nl)
- We described a protocol for dissecting the function of an important serine/threonine protein kinase, mammalian target of rapamycin (mTOR), in regulating the long-term undifferentiated growth of human embryonic stem cells (hESCs). (illinois.edu)
- RAF1 (Raf-1 proto-oncogene, serine/threonine kinase) is the cellular homolog of viral raf gene (v-raf). (abbkine.com)
- IQA [[5-oxo-5,6-dihydro-indolo(1,2-a)quinazolin-7-yl]acetic acid] is a novel ATP/GTP site-directed inhibitor of CK2 ('casein kinase 2'), a pleiotropic and constitutively active protein kinase whose activity is abnormally high in transformed cells. (dundee.ac.uk)
- Tested at 10 µM concentration in the presence of 100 µM ATP, IQA almost suppresses CK2 activity in vitro , whereas it is ineffective or weakly effective on a panel of 44 protein kinases and on phosphoinositide 3-kinase. (dundee.ac.uk)
- However, subsequent structural work revealed that the COQ8 active site is sterically occluded by UbiB-specific domains, suggesting that it possesses unorthodox functionality in lieu of typical protein kinase activity (Mol. (genemedi.net)
- 2018). This ATPase activity appears to be essential for COQ8's role in CoQ biosynthesis, where it supports the integrity of a biosynthetic complex of other CoQ-related proteins. (genemedi.net)
- UbiB kinase-like proteins exist in archaea, bacteria and eukaryotes, and comprise ~25% of all microbial protein kinase-like (PKL) enzymes. (genemedi.net)
- Regulates the cytoskeletal network by phosphorylating proteins such as VIM and neurofilament proteins NEFH, NEFL and NEFM, leading to inhibit their polymerization. (hmdb.ca)
- Furthermore, the treatment of cells with isoflavones significantly reduced the microtubule-associated protein tau hyperphosphorylation by inactivating glycogen synthase kinase-3beta and activating serine/threonine-protein phosphatase 2A. (greenmedinfo.com)
- We found that HIF-1 also actively suppresses metabolism through the tricarboxylic acid cycle (TCA) by directly trans-activating the gene encoding pyruvate dehydrogenase kinase 1 (PDK1). (nih.gov)
- Structure of the quinoline analogue UNC-CA157 with reported kinase inhibition values. (genemedi.net)
- Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine/threonine specific protein kinases, ERK1 and ERK2. (abbkine.com)
- Unless otherwise stated all data on this page refer to the human proteins. (guidetopharmacology.org)
- To confirm that MUSE286C mAb recognizes human PLK5 protein, immunocytochemistry on frozen cytospin preparations of GFP-tagged human PLK5 expressed in HEK293 was performed. (euromabnet.com)
- Cytospin preparation of human GFP-tagged human PLK1 protein was used as a negative control. (euromabnet.com)
- MUSE286C mAb is able to detect mouse and human PLK5 protein by WB. (euromabnet.com)
- PKC-related serine/threonine-protein kinase involved in various processes such as regulation of the intermediate filaments of the actin cytoskeleton and transcription regulation. (hmdb.ca)
Orthologues and is a member1
- This gene has 1 transcript ( splice variant ), 291 orthologues and is a member of 2 Ensembl protein families . (ensembl.org)
- Inactive serine/threonine-protein kinase that plays a role in cell cycle progression and neuronal differentiation. (euromabnet.com)
- Bone Morphogenetic Protein Receptors" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (childrensmercy.org)
- This graph shows the total number of publications written about "Bone Morphogenetic Protein Receptors" by people in this website by year, and whether "Bone Morphogenetic Protein Receptors" was a major or minor topic of these publications. (childrensmercy.org)
- Below are the most recent publications written about "Bone Morphogenetic Protein Receptors" by people in Profiles. (childrensmercy.org)
- The goal of IDG is to catalyse research on understudied proteins from druggable gene families by providing reagents, phenotypes and a mineable database, focusing on G protein-coupled receptors, kinases and ion channels. (genemedi.net)
- Molecular Basis of the Death-Associated Protein Kinase-Calcium/Calmodulin Regulator Complex. (cathdb.info)