Substances that are recognized by the immune system and induce an immune reaction.
Substances elaborated by bacteria that have antigenic activity.
Differentiation antigens residing on mammalian leukocytes. CD stands for cluster of differentiation, which refers to groups of monoclonal antibodies that show similar reactivity with certain subpopulations of antigens of a particular lineage or differentiation stage. The subpopulations of antigens are also known by the same CD designation.
Antigens on surfaces of cells, including infectious or foreign cells or viruses. They are usually protein-containing groups on cell membranes or walls and may be isolated.
Proteins, glycoprotein, or lipoprotein moieties on surfaces of tumor cells that are usually identified by monoclonal antibodies. Many of these are of either embryonic or viral origin.
Differentiation antigens found on thymocytes and on cytotoxic and suppressor T-lymphocytes. CD8 antigens are members of the immunoglobulin supergene family and are associative recognition elements in MHC (Major Histocompatibility Complex) Class I-restricted interactions.
Complex of at least five membrane-bound polypeptides in mature T-lymphocytes that are non-covalently associated with one another and with the T-cell receptor (RECEPTORS, ANTIGEN, T-CELL). The CD3 complex includes the gamma, delta, epsilon, zeta, and eta chains (subunits). When antigen binds to the T-cell receptor, the CD3 complex transduces the activating signals to the cytoplasm of the T-cell. The CD3 gamma and delta chains (subunits) are separate from and not related to the gamma/delta chains of the T-cell receptor (RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA).
A bifunctional enzyme that catalyzes the synthesis and HYDROLYSIS of CYCLIC ADP-RIBOSE (cADPR) from NAD+ to ADP-RIBOSE. It is a cell surface molecule which is predominantly expressed on LYMPHOID CELLS and MYELOID CELLS.
Glycoproteins found on immature hematopoietic cells and endothelial cells. They are the only molecules to date whose expression within the blood system is restricted to a small number of progenitor cells in the bone marrow.
Substances elaborated by viruses that have antigenic activity.
Differentiation antigens expressed on B-lymphocytes and B-cell precursors. They are involved in regulation of B-cell proliferation.
A member of the tumor necrosis factor receptor superfamily with specificity for CD40 LIGAND. It is found on mature B-LYMPHOCYTES and some EPITHELIAL CELLS, lymphoid DENDRITIC CELLS. Evidence suggests that CD40-dependent activation of B-cells is important for generation of memory B-cells within the germinal centers. Mutations of the gene for CD40 antigen result in HYPER-IGM IMMUNODEFICIENCY SYNDROME, TYPE 3. Signaling of the receptor occurs through its association with TNF RECEPTOR-ASSOCIATED FACTORS.
A membrane glycoprotein and differentiation antigen expressed on the surface of T-cells that binds to CD40 ANTIGENS on B-LYMPHOCYTES and induces their proliferation. Mutation of the gene for CD40 ligand is a cause of HYPER-IGM IMMUNODEFICIENCY SYNDROME, TYPE 1.
Unglycosylated phosphoproteins expressed only on B-cells. They are regulators of transmembrane Ca2+ conductance and thought to play a role in B-cell activation and proliferation.
Antibodies produced by a single clone of cells.
Costimulatory T-LYMPHOCYTE receptors that have specificity for CD80 ANTIGEN and CD86 ANTIGEN. Activation of this receptor results in increased T-cell proliferation, cytokine production and promotion of T-cell survival.
Acidic sulfated integral membrane glycoproteins expressed in several alternatively spliced and variable glycosylated forms on a wide variety of cell types including mature T-cells, B-cells, medullary thymocytes, granulocytes, macrophages, erythrocytes, and fibroblasts. CD44 antigens are the principle cell surface receptors for hyaluronate and this interaction mediates binding of lymphocytes to high endothelial venules. (From Abbas et al., Cellular and Molecular Immunology, 2d ed, p156)
Differentiation antigens expressed on pluripotential hematopoietic cells, most human thymocytes, and a major subset of peripheral blood T-lymphocytes. They have been implicated in integrin-mediated cellular adhesion and as signalling receptors on T-cells.
Glycolipid-anchored membrane glycoproteins expressed on cells of the myelomonocyte lineage including monocytes, macrophages, and some granulocytes. They function as receptors for the complex of lipopolysaccharide (LPS) and LPS-binding protein.
Lymphocytes responsible for cell-mediated immunity. Two types have been identified - cytotoxic (T-LYMPHOCYTES, CYTOTOXIC) and helper T-lymphocytes (T-LYMPHOCYTES, HELPER-INDUCER). They are formed when lymphocytes circulate through the THYMUS GLAND and differentiate to thymocytes. When exposed to an antigen, they divide rapidly and produce large numbers of new T cells sensitized to that antigen.
Sites on an antigen that interact with specific antibodies.
A critical subpopulation of T-lymphocytes involved in the induction of most immunological functions. The HIV virus has selective tropism for the T4 cell which expresses the CD4 phenotypic marker, a receptor for HIV. In fact, the key element in the profound immunosuppression seen in HIV infection is the depletion of this subset of T-lymphocytes.
Glycoprotein members of the immunoglobulin superfamily which participate in T-cell adhesion and activation. They are expressed on most peripheral T-lymphocytes, natural killer cells, and thymocytes, and function as co-receptors or accessory molecules in the T-cell receptor complex.
Glycoproteins expressed on cortical thymocytes and on some dendritic cells and B-cells. Their structure is similar to that of MHC Class I and their function has been postulated as similar also. CD1 antigens are highly specific markers for human LANGERHANS CELLS.
Ratio of T-LYMPHOCYTES that express the CD4 ANTIGEN to those that express the CD8 ANTIGEN. This value is commonly assessed in the diagnosis and staging of diseases affecting the IMMUNE SYSTEM including HIV INFECTIONS.
Glycoproteins expressed on all mature T-cells, thymocytes, and a subset of mature B-cells. Antibodies specific for CD5 can enhance T-cell receptor-mediated T-cell activation. The B-cell-specific molecule CD72 is a natural ligand for CD5. (From Abbas et al., Cellular and Molecular Immunology, 2d ed, p156)
Antigens expressed primarily on the membranes of living cells during sequential stages of maturation and differentiation. As immunologic markers they have high organ and tissue specificity and are useful as probes in studies of normal cell development as well as neoplastic transformation.
An albumin obtained from the white of eggs. It is a member of the serpin superfamily.
Immunoglobulins produced in a response to BACTERIAL ANTIGENS.
Lymphoid cells concerned with humoral immunity. They are short-lived cells resembling bursa-derived lymphocytes of birds in their production of immunoglobulin upon appropriate stimulation.
The 140 kDa isoform of NCAM (neural cell adhesion molecule) containing a transmembrane domain and short cytoplasmic tail. It is expressed by all lymphocytes mediating non-MHC restricted cytotoxicity and is present on some neural tissues and tumors.
Morphologic alteration of small B LYMPHOCYTES or T LYMPHOCYTES in culture into large blast-like cells able to synthesize DNA and RNA and to divide mitotically. It is induced by INTERLEUKINS; MITOGENS such as PHYTOHEMAGGLUTININS, and by specific ANTIGENS. It may also occur in vivo as in GRAFT REJECTION.
Antigens expressed on the cell membrane of T-lymphocytes during differentiation, activation, and normal and neoplastic transformation. Their phenotypic characterization is important in differential diagnosis and studies of thymic ontogeny and T-cell function.
Any part or derivative of any protozoan that elicits immunity; malaria (Plasmodium) and trypanosome antigens are presently the most frequently encountered.
A membrane-bound or cytosolic enzyme that catalyzes the synthesis of CYCLIC ADP-RIBOSE (cADPR) from nicotinamide adenine dinucleotide (NAD). This enzyme generally catalyzes the hydrolysis of cADPR to ADP-RIBOSE, as well, and sometimes the synthesis of cyclic ADP-ribose 2' phosphate (2'-P-cADPR) from NADP.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Surface antigens expressed on myeloid cells of the granulocyte-monocyte-histiocyte series during differentiation. Analysis of their reactivity in normal and malignant myelomonocytic cells is useful in identifying and classifying human leukemias and lymphomas.
A costimulatory ligand expressed by ANTIGEN-PRESENTING CELLS that binds to CTLA-4 ANTIGEN with high specificity and to CD28 ANTIGEN with low specificity. The interaction of CD80 with CD28 ANTIGEN provides a costimulatory signal to T-LYMPHOCYTES, while its interaction with CTLA-4 ANTIGEN may play a role in inducing PERIPHERAL TOLERANCE.
Tetraspanin proteins found at high levels in cells of the lymphoid-myeloid lineage. CD53 antigens may be involved regulating the differentiation of T-LYMPHOCYTES and the activation of B-LYMPHOCYTES.
The major immunoglobulin isotype class in normal human serum. There are several isotype subclasses of IgG, for example, IgG1, IgG2A, and IgG2B.
A cell adhesion protein that was originally identified as a heat stable antigen in mice. It is involved in METASTASIS and is highly expressed in many NEOPLASMS.
Deliberate stimulation of the host's immune response. ACTIVE IMMUNIZATION involves administration of ANTIGENS or IMMUNOLOGIC ADJUVANTS. PASSIVE IMMUNIZATION involves administration of IMMUNE SERA or LYMPHOCYTES or their extracts (e.g., transfer factor, immune RNA) or transplantation of immunocompetent cell producing tissue (thymus or bone marrow).
Technique using an instrument system for making, processing, and displaying one or more measurements on individual cells obtained from a cell suspension. Cells are usually stained with one or more fluorescent dyes specific to cell components of interest, e.g., DNA, and fluorescence of each cell is measured as it rapidly transverses the excitation beam (laser or mercury arc lamp). Fluorescence provides a quantitative measure of various biochemical and biophysical properties of the cell, as well as a basis for cell sorting. Other measurable optical parameters include light absorption and light scattering, the latter being applicable to the measurement of cell size, shape, density, granularity, and stain uptake.
Zinc-binding metalloproteases that are members of the type II integral membrane metalloproteases. They are expressed by GRANULOCYTES; MONOCYTES; and their precursors as well as by various non-hematopoietic cells. They release an N-terminal amino acid from a peptide, amide or arylamide.
The production of ANTIBODIES by proliferating and differentiated B-LYMPHOCYTES under stimulation by ANTIGENS.
A polysaccharide-producing species of STREPTOCOCCUS isolated from human dental plaque.
An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed.
A costimulatory ligand expressed by ANTIGEN-PRESENTING CELLS that binds to CD28 ANTIGEN with high specificity and to CTLA-4 ANTIGEN with low specificity. The interaction of CD86 with CD28 ANTIGEN provides a stimulatory signal to T-LYMPHOCYTES, while its interaction with CTLA-4 ANTIGEN may play a role in inducing PERIPHERAL TOLERANCE.
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
Substances of fungal origin that have antigenic activity.
Serological reactions in which an antiserum against one antigen reacts with a non-identical but closely related antigen.
The major group of transplantation antigens in the mouse.
Large, transmembrane, non-covalently linked glycoproteins (alpha and beta). Both chains can be polymorphic although there is more structural variation in the beta chains. The class II antigens in humans are called HLA-D ANTIGENS and are coded by a gene on chromosome 6. In mice, two genes named IA and IE on chromosome 17 code for the H-2 antigens. The antigens are found on B-lymphocytes, macrophages, epidermal cells, and sperm and are thought to mediate the competence of and cellular cooperation in the immune response. The term IA antigens used to refer only to the proteins encoded by the IA genes in the mouse, but is now used as a generic term for any class II histocompatibility antigen.
Glycoproteins found on the membrane or surface of cells.
Polyomavirus antigens which cause infection and cellular transformation. The large T antigen is necessary for the initiation of viral DNA synthesis, repression of transcription of the early region and is responsible in conjunction with the middle T antigen for the transformation of primary cells. Small T antigen is necessary for the completion of the productive infection cycle.
A critical subpopulation of regulatory T-lymphocytes involved in MHC Class I-restricted interactions. They include both cytotoxic T-lymphocytes (T-LYMPHOCYTES, CYTOTOXIC) and CD8+ suppressor T-lymphocytes.
A tumor necrosis factor receptor subtype found in a variety of tissues and on activated LYMPHOCYTES. It has specificity for FAS LIGAND and plays a role in regulation of peripheral immune responses and APOPTOSIS. Multiple isoforms of the protein exist due to multiple ALTERNATIVE SPLICING. The activated receptor signals via a conserved death domain that associates with specific TNF RECEPTOR-ASSOCIATED FACTORS in the CYTOPLASM.
Antigens determined by leukocyte loci found on chromosome 6, the major histocompatibility loci in humans. They are polypeptides or glycoproteins found on most nucleated cells and platelets, determine tissue types for transplantation, and are associated with certain diseases.
Proteins found in any species of bacterium.
Membrane antigens associated with maturation stages of B-lymphocytes, often expressed in tumors of B-cell origin.
High-molecular weight glycoproteins uniquely expressed on the surface of LEUKOCYTES and their hemopoietic progenitors. They contain a cytoplasmic protein tyrosine phosphatase activity which plays a role in intracellular signaling from the CELL SURFACE RECEPTORS. The CD45 antigens occur as multiple isoforms that result from alternative mRNA splicing and differential usage of three exons.
The property of antibodies which enables them to react with some ANTIGENIC DETERMINANTS and not with others. Specificity is dependent on chemical composition, physical forces, and molecular structure at the binding site.
Process of classifying cells of the immune system based on structural and functional differences. The process is commonly used to analyze and sort T-lymphocytes into subsets based on CD antigens by the technique of flow cytometry.
A heterogeneous group of immunocompetent cells that mediate the cellular immune response by processing and presenting antigens to the T-cells. Traditional antigen-presenting cells include MACROPHAGES; DENDRITIC CELLS; LANGERHANS CELLS; and B-LYMPHOCYTES. FOLLICULAR DENDRITIC CELLS are not traditional antigen-presenting cells, but because they hold antigen on their cell surface in the form of IMMUNE COMPLEXES for B-cell recognition they are considered so by some authors.
A 67-kDa sialic acid binding lectin that is specific for MYELOID CELLS and MONOCYTE-MACROPHAGE PRECURSOR CELLS. This protein is the smallest siglec subtype and contains a single immunoglobulin C2-set domain. It may play a role in intracellular signaling via its interaction with SHP-1 PROTEIN-TYROSINE PHOSPHATASE and SHP-2 PROTEIN-TYROSINE PHOSPHATASE.
A subclass of HLA-D antigens that consist of alpha and beta chains. The inheritance of HLA-DR antigens differs from that of the HLA-DQ ANTIGENS and HLA-DP ANTIGENS.
Any part or derivative of a helminth that elicits an immune reaction. The most commonly seen helminth antigens are those of the schistosomes.
Molecules on the surface of T-lymphocytes that recognize and combine with antigens. The receptors are non-covalently associated with a complex of several polypeptides collectively called CD3 antigens (ANTIGENS, CD3). Recognition of foreign antigen and the major histocompatibility complex is accomplished by a single heterodimeric antigen-receptor structure, composed of either alpha-beta (RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA) or gamma-delta (RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA) chains.
Cell-surface glycoprotein beta-chains that are non-covalently linked to specific alpha-chains of the CD11 family of leukocyte-adhesion molecules (RECEPTORS, LEUKOCYTE-ADHESION). A defect in the gene encoding CD18 causes LEUKOCYTE-ADHESION DEFICIENCY SYNDROME.
Established cell cultures that have the potential to propagate indefinitely.
Substances that augment, stimulate, activate, potentiate, or modulate the immune response at either the cellular or humoral level. The classical agents (Freund's adjuvant, BCG, Corynebacterium parvum, et al.) contain bacterial antigens. Some are endogenous (e.g., histamine, interferon, transfer factor, tuftsin, interleukin-1). Their mode of action is either non-specific, resulting in increased immune responsiveness to a wide variety of antigens, or antigen-specific, i.e., affecting a restricted type of immune response to a narrow group of antigens. The therapeutic efficacy of many biological response modifiers is related to their antigen-specific immunoadjuvanticity.
An encapsulated lymphatic organ through which venous blood filters.
A member of the tumor necrosis factor receptor superfamily that may play a role in the regulation of NF-KAPPA B and APOPTOSIS. They are found on activated T-LYMPHOCYTES; B-LYMPHOCYTES; NEUTROPHILS; EOSINOPHILS; MAST CELLS and NK CELLS. Overexpression of CD30 antigen in hematopoietic malignancies make the antigen clinically useful as a biological tumor marker. Signaling of the receptor occurs through its association with TNF RECEPTOR-ASSOCIATED FACTORS.
The processes triggered by interactions of ANTIBODIES with their ANTIGENS.
An increased reactivity to specific antigens mediated not by antibodies but by cells.
Serum that contains antibodies. It is obtained from an animal that has been immunized either by ANTIGEN injection or infection with microorganisms containing the antigen.
Specialized cells of the hematopoietic system that have branch-like extensions. They are found throughout the lymphatic system, and in non-lymphoid tissues such as SKIN and the epithelia of the intestinal, respiratory, and reproductive tracts. They trap and process ANTIGENS, and present them to T-CELLS, thereby stimulating CELL-MEDIATED IMMUNITY. They are different from the non-hematopoietic FOLLICULAR DENDRITIC CELLS, which have a similar morphology and immune system function, but with respect to humoral immunity (ANTIBODY PRODUCTION).
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
A subtype of tetraspanin proteins that play a role in cell adhesion, cell motility, and tumor metastasis. CD9 antigens take part in the process of platelet activation and aggregation, the formation of paranodal junctions in neuronal tissue, and the fusion of sperm with egg.
A glycoprotein that is secreted into the luminal surface of the epithelia in the gastrointestinal tract. It is found in the feces and pancreaticobiliary secretions and is used to monitor the response to colon cancer treatment.
A trisaccharide antigen expressed on glycolipids and many cell-surface glycoproteins. In the blood the antigen is found on the surface of NEUTROPHILS; EOSINOPHILS; and MONOCYTES. In addition, CD15 antigen is a stage-specific embryonic antigen.
Those proteins recognized by antibodies from serum of animals bearing tumors induced by viruses; these proteins are presumably coded for by the nucleic acids of the same viruses that caused the neoplastic transformation.
The sum of the weight of all the atoms in a molecule.
Immunoglobulin molecules having a specific amino acid sequence by virtue of which they interact only with the ANTIGEN (or a very similar shape) that induced their synthesis in cells of the lymphoid series (especially PLASMA CELLS).
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.
A sialic acid-rich protein and an integral cell membrane mucin. It plays an important role in activation of T-LYMPHOCYTES.
The specific failure of a normally responsive individual to make an immune response to a known antigen. It results from previous contact with the antigen by an immunologically immature individual (fetus or neonate) or by an adult exposed to extreme high-dose or low-dose antigen, or by exposure to radiation, antimetabolites, antilymphocytic serum, etc.
A species of gram-positive, coccoid bacteria isolated from the human tooth surface. Strains have been shown to be cariogenic in experimental animals and may be associated with human dental caries.
Leukocyte differentiation antigens and major platelet membrane glycoproteins present on MONOCYTES; ENDOTHELIAL CELLS; PLATELETS; and mammary EPITHELIAL CELLS. They play major roles in CELL ADHESION; SIGNAL TRANSDUCTION; and regulation of angiogenesis. CD36 is a receptor for THROMBOSPONDINS and can act as a scavenger receptor that recognizes and transports oxidized LIPOPROTEINS and FATTY ACIDS.
Proteins prepared by recombinant DNA technology.
A group of three different alpha chains (CD11a, CD11b, CD11c) that are associated with an invariant CD18 beta chain (ANTIGENS, CD18). The three resulting leukocyte-adhesion molecules (RECEPTORS, LEUKOCYTE ADHESION) are LYMPHOCYTE FUNCTION-ASSOCIATED ANTIGEN-1; MACROPHAGE-1 ANTIGEN; and ANTIGEN, P150,95.
A species of gram-positive, aerobic bacteria that causes LEPROSY in man. Its organisms are generally arranged in clumps, rounded masses, or in groups of bacilli side by side.
A group of antigens that includes both the major and minor histocompatibility antigens. The former are genetically determined by the major histocompatibility complex. They determine tissue type for transplantation and cause allograft rejections. The latter are systems of allelic alloantigens that can cause weak transplant rejection.
Small glycoproteins found on both hematopoietic and non-hematopoietic cells. CD59 restricts the cytolytic activity of homologous complement by binding to C8 and C9 and blocking the assembly of the membrane attack complex. (From Barclay et al., The Leukocyte Antigen FactsBook, 1993, p234)
Membrane glycoproteins consisting of an alpha subunit and a BETA 2-MICROGLOBULIN beta subunit. In humans, highly polymorphic genes on CHROMOSOME 6 encode the alpha subunits of class I antigens and play an important role in determining the serological specificity of the surface antigen. Class I antigens are found on most nucleated cells and are generally detected by their reactivity with alloantisera. These antigens are recognized during GRAFT REJECTION and restrict cell-mediated lysis of virus-infected cells.
Test for tissue antigen using either a direct method, by conjugation of antibody with fluorescent dye (FLUORESCENT ANTIBODY TECHNIQUE, DIRECT) or an indirect method, by formation of antigen-antibody complex which is then labeled with fluorescein-conjugated anti-immunoglobulin antibody (FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT). The tissue is then examined by fluorescence microscopy.
Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations, or by parent x offspring matings carried out with certain restrictions. All animals within an inbred strain trace back to a common ancestor in the twentieth generation.
IMMUNOGLOBULINS on the surface of B-LYMPHOCYTES. Their MESSENGER RNA contains an EXON with a membrane spanning sequence, producing immunoglobulins in the form of type I transmembrane proteins as opposed to secreted immunoglobulins (ANTIBODIES) which do not contain the membrane spanning segment.
A class of immunoglobulin bearing mu chains (IMMUNOGLOBULIN MU-CHAINS). IgM can fix COMPLEMENT. The name comes from its high molecular weight and originally being called a macroglobulin.
The altered state of immunologic responsiveness resulting from initial contact with antigen, which enables the individual to produce antibodies more rapidly and in greater quantity in response to secondary antigenic stimulus.
Nuclear antigen with a role in DNA synthesis, DNA repair, and cell cycle progression. PCNA is required for the coordinated synthesis of both leading and lagging strands at the replication fork during DNA replication. PCNA expression correlates with the proliferation activity of several malignant and non-malignant cell types.
Histochemical localization of immunoreactive substances using labeled antibodies as reagents.
Electrophoresis in which a polyacrylamide gel is used as the diffusion medium.
The complex formed by the binding of antigen and antibody molecules. The deposition of large antigen-antibody complexes leading to tissue damage causes IMMUNE COMPLEX DISEASES.
Oligosaccharide antigenic determinants found principally on NK cells and T-cells. Their role in the immune response is poorly understood.
A transmembrane protein belonging to the tumor necrosis factor superfamily that specifically binds to CD27 ANTIGEN. It is found on activated T-LYMPHOCYTES; B-LYMPHOCYTES; and DENDRITIC CELLS where it plays a role in stimulating the proliferation of CD4-POSITIVE T-LYMPHOCYTES and CD8-POSITIVE T-LYMPHOCYTES.
A ubiquitously expressed complement receptor that binds COMPLEMENT C3B and COMPLEMENT C4B and serves as a cofactor for their inactivation. CD46 also interacts with a wide variety of pathogens and mediates immune response.
Suspensions of attenuated or killed bacteria administered for the prevention or treatment of infectious bacterial disease.
A class of animal lectins that bind to carbohydrate in a calcium-dependent manner. They share a common carbohydrate-binding domain that is structurally distinct from other classes of lectins.
Glycoproteins with a wide distribution on hematopoietic and non-hematopoietic cells and strongly expressed on macrophages. CD58 mediates cell adhesion by binding to CD2; (ANTIGENS, CD2); and this enhances antigen-specific T-cell activation.
White blood cells formed in the body's lymphoid tissue. The nucleus is round or ovoid with coarse, irregularly clumped chromatin while the cytoplasm is typically pale blue with azurophilic (if any) granules. Most lymphocytes can be classified as either T or B (with subpopulations of each), or NATURAL KILLER CELLS.
55-kDa antigens found on HELPER-INDUCER T-LYMPHOCYTES and on a variety of other immune cell types. CD4 antigens are members of the immunoglobulin supergene family and are implicated as associative recognition elements in MAJOR HISTOCOMPATIBILITY COMPLEX class II-restricted immune responses. On T-lymphocytes they define the helper/inducer subset. CD4 antigens also serve as INTERLEUKIN-15 receptors and bind to the HIV receptors, binding directly to the HIV ENVELOPE PROTEIN GP120.
A ubiquitously expressed membrane glycoprotein. It interacts with a variety of INTEGRINS and mediates responses to EXTRACELLULAR MATRIX PROTEINS.
Immunized T-lymphocytes which can directly destroy appropriate target cells. These cytotoxic lymphocytes may be generated in vitro in mixed lymphocyte cultures (MLC), in vivo during a graft-versus-host (GVH) reaction, or after immunization with an allograft, tumor cell or virally transformed or chemically modified target cell. The lytic phenomenon is sometimes referred to as cell-mediated lympholysis (CML). These CD8-positive cells are distinct from NATURAL KILLER CELLS and NATURAL KILLER T-CELLS. There are two effector phenotypes: TC1 and TC2.
A CD antigen that contains a conserved I domain which is involved in ligand binding. When combined with CD18 the two subunits form MACROPHAGE-1 ANTIGEN.
The species Oryctolagus cuniculus, in the family Leporidae, order LAGOMORPHA. Rabbits are born in burrows, furless, and with eyes and ears closed. In contrast with HARES, rabbits have 22 chromosome pairs.
A glycoprotein that is a kallikrein-like serine proteinase and an esterase, produced by epithelial cells of both normal and malignant prostate tissue. It is an important marker for the diagnosis of prostate cancer.
Progressive restriction of the developmental potential and increasing specialization of function that leads to the formation of specialized cells, tissues, and organs.
An integrin alpha subunit of approximately 150-kDa molecular weight. It is expressed at high levels on monocytes and combines with CD18 ANTIGEN to form the cell surface receptor INTEGRIN ALPHAXBETA2. The subunit contains a conserved I-domain which is characteristic of several of alpha integrins.
Serum albumin from cows, commonly used in in vitro biological studies. (From Stedman, 25th ed)
The lipopolysaccharide-protein somatic antigens, usually from gram-negative bacteria, important in the serological classification of enteric bacilli. The O-specific chains determine the specificity of the O antigens of a given serotype. O antigens are the immunodominant part of the lipopolysaccharide molecule in the intact bacterial cell. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)
A specific HLA-A surface antigen subtype. Members of this subtype contain alpha chains that are encoded by the HLA-A*02 allele family.
Technique involving the diffusion of antigen or antibody through a semisolid medium, usually agar or agarose gel, with the result being a precipitin reaction.
Manifestations of the immune response which are mediated by antigen-sensitized T-lymphocytes via lymphokines or direct cytotoxicity. This takes place in the absence of circulating antibody or where antibody plays a subordinate role.
Members of the class of compounds composed of AMINO ACIDS joined together by peptide bonds between adjacent amino acids into linear, branched or cyclical structures. OLIGOPEPTIDES are composed of approximately 2-12 amino acids. Polypeptides are composed of approximately 13 or more amino acids. PROTEINS are linear polypeptides that are normally synthesized on RIBOSOMES.
Progenitor cells from which all blood cells derive.
The number of CD4-POSITIVE T-LYMPHOCYTES per unit volume of BLOOD. Determination requires the use of a fluorescence-activated flow cytometer.
They are oval or bean shaped bodies (1 - 30 mm in diameter) located along the lymphatic system.
A complex mixture of PHOSPHOLIPIDS; GLYCOLIPIDS; and TRIGLYCERIDES; with substantial amounts of PHOSPHATIDYLCHOLINES; PHOSPHATIDYLETHANOLAMINES; and PHOSPHATIDYLINOSITOLS, which are sometimes loosely termed as 1,2-diacyl-3-phosphocholines. Lecithin is a component of the CELL MEMBRANE and commercially extracted from SOYBEANS and EGG YOLK. The emulsifying and surfactant properties are useful in FOOD ADDITIVES and for forming organogels (GELS).
Recombinant proteins produced by the GENETIC TRANSLATION of fused genes formed by the combination of NUCLEIC ACID REGULATORY SEQUENCES of one or more genes with the protein coding sequences of one or more genes.
The process by which antigen is presented to lymphocytes in a form they can recognize. This is performed by antigen presenting cells (APCs). Some antigens require processing before they can be recognized. Antigen processing consists of ingestion and partial digestion of the antigen by the APC, followed by presentation of fragments on the cell surface. (From Rosen et al., Dictionary of Immunology, 1989)
Carbohydrate antigens expressed by malignant tissue. They are useful as tumor markers and are measured in the serum by means of a radioimmunoassay employing monoclonal antibodies.
Small synthetic peptides that mimic surface antigens of pathogens and are immunogenic, or vaccines manufactured with the aid of recombinant DNA techniques. The latter vaccines may also be whole viruses whose nucleic acids have been modified.
GPI-linked membrane proteins broadly distributed among hematopoietic and non-hematopoietic cells. CD55 prevents the assembly of C3 CONVERTASE or accelerates the disassembly of preformed convertase, thus blocking the formation of the membrane attack complex.
Cell adhesion molecules present on virtually all monocytes, platelets, and granulocytes. CD31 is highly expressed on endothelial cells and concentrated at the junctions between them.
Proteins isolated from the outer membrane of Gram-negative bacteria.
Cells grown in vitro from neoplastic tissue. If they can be established as a TUMOR CELL LINE, they can be propagated in cell culture indefinitely.
Tetraspanin proteins that are involved in a variety of cellular functions including BASEMENT MEMBRANE assembly, and in the formation of a molecular complexes on the surface of LYMPHOCYTES.
Serum globulins that migrate to the gamma region (most positively charged) upon ELECTROPHORESIS. At one time, gamma-globulins came to be used as a synonym for immunoglobulins since most immunoglobulins are gamma globulins and conversely most gamma globulins are immunoglobulins. But since some immunoglobulins exhibit an alpha or beta electrophoretic mobility, that usage is in decline.
A basic enzyme that is present in saliva, tears, egg white, and many animal fluids. It functions as an antibacterial agent. The enzyme catalyzes the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrin. EC
A group of genetically identical cells all descended from a single common ancestral cell by mitosis in eukaryotes or by binary fission in prokaryotes. Clone cells also include populations of recombinant DNA molecules all carrying the same inserted sequence. (From King & Stansfield, Dictionary of Genetics, 4th ed)
Suspensions of killed or attenuated microorganisms (bacteria, viruses, fungi, protozoa), antigenic proteins, synthetic constructs, or other bio-molecular derivatives, administered for the prevention, amelioration, or treatment of infectious and other diseases.
A member of the tumor necrosis factor receptor superfamily that is specific for 4-1BB LIGAND. It is found in a variety of immune cell types including activated T-LYMPHOCYTES; NATURAL KILLER CELLS; and DENDRITIC CELLS. Activation of the receptor on T-LYMPHOCYTES plays a role in their expansion, production of cytokines and survival. Signaling by the activated receptor occurs through its association with TNF RECEPTOR-ASSOCIATED FACTORS.
Burrowing, chiefly nocturnal mammals of the family Dasypodidae having bodies and heads encased in small bony plates. They are widely distributed in the warmer parts of the Americas.
Represents 15-20% of the human serum immunoglobulins, mostly as the 4-chain polymer in humans or dimer in other mammals. Secretory IgA (IMMUNOGLOBULIN A, SECRETORY) is the main immunoglobulin in secretions.
The major interferon produced by mitogenically or antigenically stimulated LYMPHOCYTES. It is structurally different from TYPE I INTERFERON and its major activity is immunoregulation. It has been implicated in the expression of CLASS II HISTOCOMPATIBILITY ANTIGENS in cells that do not normally produce them, leading to AUTOIMMUNE DISEASES.
Local surface sites on antibodies which react with antigen determinant sites on antigens (EPITOPES.) They are formed from parts of the variable regions of FAB FRAGMENTS.
A measure of the binding strength between antibody and a simple hapten or antigen determinant. It depends on the closeness of stereochemical fit between antibody combining sites and antigen determinants, on the size of the area of contact between them, and on the distribution of charged and hydrophobic groups. It includes the concept of "avidity," which refers to the strength of the antigen-antibody bond after formation of reversible complexes.
The relatively long-lived phagocytic cell of mammalian tissues that are derived from blood MONOCYTES. Main types are PERITONEAL MACROPHAGES; ALVEOLAR MACROPHAGES; HISTIOCYTES; KUPFFER CELLS of the liver; and OSTEOCLASTS. They may further differentiate within chronic inflammatory lesions to EPITHELIOID CELLS or may fuse to form FOREIGN BODY GIANT CELLS or LANGHANS GIANT CELLS. (from The Dictionary of Cell Biology, Lackie and Dow, 3rd ed.)
A gram-negative, rod-shaped to coccoid bacterium. It is the etiologic agent of SCRUB TYPHUS in humans and is transmitted by mites from rodent reservoirs.
The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment.
Large, phagocytic mononuclear leukocytes produced in the vertebrate BONE MARROW and released into the BLOOD; contain a large, oval or somewhat indented nucleus surrounded by voluminous cytoplasm and numerous organelles.
A genus of gram-positive, coccoid bacteria whose organisms occur in pairs or chains. No endospores are produced. Many species exist as commensals or parasites on man or animals with some being highly pathogenic. A few species are saprophytes and occur in the natural environment.
Polymorphic class I human histocompatibility (HLA) surface antigens present on almost all nucleated cells. At least 20 antigens have been identified which are encoded by the A locus of multiple alleles on chromosome 6. They serve as targets for T-cell cytolytic responses and are involved with acceptance or rejection of tissue/organ grafts.
Cells artificially created by fusion of activated lymphocytes with neoplastic cells. The resulting hybrid cells are cloned and produce pure MONOCLONAL ANTIBODIES or T-cell products, identical to those produced by the immunologically competent parent cell.
Laboratory mice that have been produced from a genetically manipulated EGG or EMBRYO, MAMMALIAN.
Receptors present on activated T-LYMPHOCYTES and B-LYMPHOCYTES that are specific for INTERLEUKIN-2 and play an important role in LYMPHOCYTE ACTIVATION. They are heterotrimeric proteins consisting of the INTERLEUKIN-2 RECEPTOR ALPHA SUBUNIT, the INTERLEUKIN-2 RECEPTOR BETA SUBUNIT, and the INTERLEUKIN RECEPTOR COMMON GAMMA-CHAIN.
Non-antibody proteins secreted by inflammatory leukocytes and some non-leukocytic cells, that act as intercellular mediators. They differ from classical hormones in that they are produced by a number of tissue or cell types rather than by specialized glands. They generally act locally in a paracrine or autocrine rather than endocrine manner.
Techniques used to demonstrate or measure an immune response, and to identify or measure antigens using antibodies.
Sets of cell surface antigens located on BLOOD CELLS. They are usually membrane GLYCOPROTEINS or GLYCOLIPIDS that are antigenically distinguished by their carbohydrate moieties.
Those hepatitis B antigens found on the surface of the Dane particle and on the 20 nm spherical and tubular particles. Several subspecificities of the surface antigen are known. These were formerly called the Australia antigen.
A technique using antibodies for identifying or quantifying a substance. Usually the substance being studied serves as antigen both in antibody production and in measurement of antibody by the test substance.
Ubiquitously-expressed tetraspanin proteins that are found in late ENDOSOMES and LYSOSOMES and have been implicated in intracellular transport of proteins.
The genetic region which contains the loci of genes which determine the structure of the serologically defined (SD) and lymphocyte-defined (LD) TRANSPLANTATION ANTIGENS, genes which control the structure of the IMMUNE RESPONSE-ASSOCIATED ANTIGENS, HUMAN; the IMMUNE RESPONSE GENES which control the ability of an animal to respond immunologically to antigenic stimuli, and genes which determine the structure and/or level of the first four components of complement.
Subpopulation of CD4+ lymphocytes that cooperate with other lymphocytes (either T or B) to initiate a variety of immune functions. For example, helper-inducer T-cells cooperate with B-cells to produce antibodies to thymus-dependent antigens and with other subpopulations of T-cells to initiate a variety of cell-mediated immune functions.
Transfer of immunity from immunized to non-immune host by administration of serum antibodies, or transplantation of lymphocytes (ADOPTIVE TRANSFER).
A species of gram-positive, aerobic bacteria that produces TUBERCULOSIS in humans, other primates, CATTLE; DOGS; and some other animals which have contact with humans. Growth tends to be in serpentine, cordlike masses in which the bacilli show a parallel orientation.
The uptake of naked or purified DNA by CELLS, usually meaning the process as it occurs in eukaryotic cells. It is analogous to bacterial transformation (TRANSFORMATION, BACTERIAL) and both are routinely employed in GENE TRANSFER TECHNIQUES.
The phenomenon of target cell destruction by immunologically active effector cells. It may be brought about directly by sensitized T-lymphocytes or by lymphoid or myeloid "killer" cells, or it may be mediated by cytotoxic antibody, cytotoxic factor released by lymphoid cells, or complement.
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
The fission of a CELL. It includes CYTOKINESIS, when the CYTOPLASM of a cell is divided, and CELL NUCLEUS DIVISION.
The restriction of a characteristic behavior, anatomical structure or physical system, such as immune response; metabolic response, or gene or gene variant to the members of one species. It refers to that property which differentiates one species from another but it is also used for phylogenetic levels higher or lower than the species.
A soluble substance elaborated by antigen- or mitogen-stimulated T-LYMPHOCYTES which induces DNA synthesis in naive lymphocytes.
Endogenous tissue constituents that have the ability to interact with AUTOANTIBODIES and cause an immune response.
Tetraspanin proteins found associated with LAMININ-binding INTEGRINS. The CD151 antigens may play a role in the regulation of CELL MOTILITY.
A component of the B-cell antigen receptor that is involved in B-cell antigen receptor heavy chain transport to the PLASMA MEMBRANE. It is expressed almost exclusively in B-LYMPHOCYTES and serves as a useful marker for B-cell NEOPLASMS.
Immunologic techniques based on the use of: (1) enzyme-antibody conjugates; (2) enzyme-antigen conjugates; (3) antienzyme antibody followed by its homologous enzyme; or (4) enzyme-antienzyme complexes. These are used histologically for visualizing or labeling tissue specimens.
Benzene derivatives which are substituted with three nitro groups in any position.
Small antigenic determinants capable of eliciting an immune response only when coupled to a carrier. Haptens bind to antibodies but by themselves cannot elicit an antibody response.
Administration of vaccines to stimulate the host's immune response. This includes any preparation intended for active immunological prophylaxis.
Proteins which are found in membranes including cellular and intracellular membranes. They consist of two types, peripheral and integral proteins. They include most membrane-associated enzymes, antigenic proteins, transport proteins, and drug, hormone, and lectin receptors.
A method to identify and enumerate cells that are synthesizing ANTIBODIES against ANTIGENS or HAPTENS conjugated to sheep RED BLOOD CELLS. The sheep red blood cells surrounding cells secreting antibody are lysed by added COMPLEMENT producing a clear zone of HEMOLYSIS. (From Illustrated Dictionary of Immunology, 3rd ed)
Polysaccharides found in bacteria and in capsules thereof.
Human immune-response or Class II antigens found mainly, but not exclusively, on B-lymphocytes and produced from genes of the HLA-D locus. They are extremely polymorphic families of glycopeptides, each consisting of two chains, alpha and beta. This group of antigens includes the -DR, -DQ and -DP designations, of which HLA-DR is most studied; some of these glycoproteins are associated with certain diseases, possibly of immune etiology.
A membrane-bound tumor necrosis family member found primarily on activated T-LYMPHOCYTES that binds specifically to CD30 ANTIGEN. It may play a role in INFLAMMATION and immune regulation.
The bovine variety of the tubercle bacillus. It is called also Mycobacterium tuberculosis var. bovis.
A class of enzymes involved in the hydrolysis of the N-glycosidic bond of nitrogen-linked sugars.
Multi-subunit proteins which function in IMMUNITY. They are produced by B LYMPHOCYTES from the IMMUNOGLOBULIN GENES. They are comprised of two heavy (IMMUNOGLOBULIN HEAVY CHAINS) and two light chains (IMMUNOGLOBULIN LIGHT CHAINS) with additional ancillary polypeptide chains depending on their isoforms. The variety of isoforms include monomeric or polymeric forms, and transmembrane forms (B-CELL ANTIGEN RECEPTORS) or secreted forms (ANTIBODIES). They are divided by the amino acid sequence of their heavy chains into five classes (IMMUNOGLOBULIN A; IMMUNOGLOBULIN D; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M) and various subclasses.
A bacterium which causes mastitis in cattle and occasionally in man.
A technique that combines protein electrophoresis and double immunodiffusion. In this procedure proteins are first separated by gel electrophoresis (usually agarose), then made visible by immunodiffusion of specific antibodies. A distinct elliptical precipitin arc results for each protein detectable by the antisera.
Partial proteins formed by partial hydrolysis of complete proteins or generated through PROTEIN ENGINEERING techniques.
A specific immune response elicited by a specific dose of an immunologically active substance or cell in an organism, tissue, or cell.
A form of undifferentiated malignant LYMPHOMA usually found in central Africa, but also reported in other parts of the world. It is commonly manifested as a large osteolytic lesion in the jaw or as an abdominal mass. B-cell antigens are expressed on the immature cells that make up the tumor in virtually all cases of Burkitt lymphoma. The Epstein-Barr virus (HERPESVIRUS 4, HUMAN) has been isolated from Burkitt lymphoma cases in Africa and it is implicated as the causative agent in these cases; however, most non-African cases are EBV-negative.
Molecules on the surface of B- and T-lymphocytes that recognize and combine with specific antigens.
Immunoglobulins produced in response to VIRAL ANTIGENS.
Diagnostic procedures involving immunoglobulin reactions.
Gomes I, Sharma TT, Edassery S, Fulton N, Mar BG, Westbrook CA (Jun 2002). "Novel transcription factors in human CD34 antigen- ... 2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. ... SPT20 homolog is a protein that in humans is encoded by the SUPT20H gene. GRCh38: Ensembl release 89: ENSG00000102710 - Ensembl ... 2006). "p38 and a p38-interacting protein are critical for downregulation of E-cadherin during mouse gastrulation". Cell. 125 ( ...
"CD68 Gene - CD68 Protein - CD68 Antibody". Retrieved 16 September 2017. "MACROPHAGE ANTIGEN CD68; CD68". ... the hematopoietic mucin-like family of molecules that includes leukosialin/CD43 and stem cell antigen CD34; the lysosomal/ ... protein gene product 9.5, S100 protein, CD68, and Ki-67 proliferative index with clinical correlation". Archives of Pathology ... The human CD68 protein is encoded by the "CD68" gene which maps to Chromosome 17. Other names or aliases for this gene in ...
"Activated protein kinase C directly phosphorylates the CD34 antigen on hematopoietic cells". The Journal of Biological ... Antigens,+CD34 at the US National Library of Medicine Medical Subject Headings (MeSH) Mouse CD Antigen Chart Human CD Antigen ... CD34 is a transmembrane phosphoglycoprotein protein encoded by the CD34 gene in humans, mice, rats and other species. CD34 ... The CD34 protein is a member of a family of single-pass transmembrane sialomucin proteins that show expression on early ...
... is a protein that in humans is encoded by the SPAG7 gene. GRCh38: Ensembl release 89: ... "Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient ... PDBe-KB provides an overview of all the structure information available in the PDB for Human Sperm-associated antigen 7 v t e. ... Beaton S, Cleary A, ten Have J, Bradley MP (1995). "Cloning and characterization of a fox sperm protein FSA-1". Reproduction, ...
... Hematopoietic progenitor cell antigen CD34 also known as CD34 antigen is a protein that in humans is encoded by the CD34 ... The CD34 protein is a member of a family of single-pass transmembrane sialomucin proteins that show expression on early ... "Activated protein kinase C directly phosphorylates the CD34 antigen on hematopoietic cells". The Journal of Biological ... CD34 CD34 molecule".. *^ Simmons DL, Satterthwaite AB, Tenen DG, Seed B (Jan 1992). "Molecular cloning of a cDNA encoding CD34 ...
2002). "Novel transcription factors in human CD34 antigen-positive hematopoietic cells". Blood. 100 (1): 107-19. doi:10.1182/ ... 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173-8. Bibcode: ... DIDO1+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH) This article incorporates text from ... Death-inducer obliterator 1 is a protein that in humans is encoded by the DIDO1 gene. Apoptosis, a major form of cell death, is ...
At the end of the 1980s the three-dimensional structure of human leukocyte antigen (HLA) molecule was defined in parallel to ... The peptides contain the various mutations that are present in the catalytic site of the Ras protein. In 1993, five patients ... He further generated monoclonal antibodies specific for the hematopoietic stem cell marker, CD34. A joint collaboration with ... These data clearly demonstrated vaccine-specific immune responses with a broad specter of T cell response against antigens ...
... are extracted from the person and purified so that only CD34-expressing cells remain. Those cells are cultured with cytokines ... for whom no suitable human leukocyte antigen (HLA)-matched related stem cell donor is available. The treatment is personalized ... replicating and creating cells that mature and create normally functioning adenosine deaminase protein, resolving the problem. ...
1998). "Identification of podocalyxin-like protein as a high endothelial venule ligand for L-selectin: parallels to CD34". J. ... need to enter secondary lymph nodes to encounter their antigen. Central memory T-lymphocytes, which have encountered antigen, ... CD34, found on endothelial cells. MadCAM-1, found on endothelial cells of gut-associated lymphoid tissue. PSGL-1, binds with ... Here they reside ready to proliferate upon re-encountering antigen. Effector memory T-lymphocytes do not express L-selectin, as ...
2002). "Cell surface antigen CD109 is a novel member of the alpha(2) macroglobulin/C3, C4, C5 family of thioester-containing ... Lewandrowski U, Moebius J, Walter U, Sickmann A (2006). "Elucidation of N-glycosylation sites on human platelet proteins: a ... 2003). "Antibody W7C5 defines a CD109 epitope expressed on CD34+ and CD34- hematopoietic and mesenchymal stem cell subsets". ... CD109+Antigen at the US National Library of Medicine Medical Subject Headings (MeSH) Human CD109 genome location and CD109 gene ...
CD34 CD44 NCAM (CD56) CD73 CD9 CD90 CDCP1 Circulating anticoagulants protein C (PC) CK19 CLV3 cyclic CMP ECMA-7 EDR1 EEC FGF-4 ... PSCs pSV2gpt PTPRC purified LRC Rat liver fatty acid-binding protein/human growth hormone transgenes (Fabpl/hGH) RC1 antigen ... Below is a list of genes/protein products that can be used to identify various types of stem cells, or functional assays that ... CK19, Cytokeratin 19, K19) Kit L-selectin (CD62L) Lamin A/C Lewis X antigen (Le(X)) LeX Lgr5 Lrp4 MCM2 MCSP Metallothionein (MT ...
Table of CD Antigens CD list Protein Reviews On The Web Yet another list of CD molecules, at Wall charts ... For example, a "CD34+, CD31−" cell is one that expresses CD34, but not CD31. This CD combination typically corresponds to a ... A signal cascade is usually initiated, altering the behavior of the cell (see cell signaling). Some CD proteins do not play a ... White Cell Differentiation Antigens. Oxford University Press. Knapp, W; et al. (1989). Leucocyte Typing IV. Oxford University ...
Endomucin is a protein that in humans is encoded by the EMCN gene. Endomucin is a marker for endothelial cells and ... 2005). "Endomucin, a CD34-like sialomucin, marks hematopoietic stem cells throughout development". Journal of Experimental ... Li G, Miles A, Line A, Rees RC (March 2004). "Identification of tumour antigens by serological analysis of cDNA expression ...
Podocalyxin-like protein 1 is a protein that in humans is encoded by the PODXL gene. This gene encodes a member of the CD34 ... Schopperle WM, Kershaw DB, DeWolf WC (Jan 2003). "Human embryonal carcinoma tumor antigen, Gp200/GCTM-2, is podocalyxin". ... Other biological activities of the encoded protein include: binding in a membrane protein complex with Na+/H+ exchanger ... and perinatal lethality in mice lacking the CD34-related protein podocalyxin". The Journal of Experimental Medicine. 194 (1): ...
This antigen stimulated phosphorylation causes the activation of other proteins in the FcεR1-mediated signaling cascade. An ... since part of them is positive for the CD34 antigen. The classical mast cell markers include the high-affinity IgE receptor, ... In general, allergens are proteins or polysaccharides. The allergen binds to the antigen-binding sites, which are situated on ... The antigen cross-links the FcεR1 molecules, and Lyn tyrosine kinase phosphorylates the ITAMs in the FcεR1 β and γ chain in the ...
... antigens, cd30 MeSH D23.050.301.264.035.131 - antigens, cd31 MeSH D23.050.301.264.035.134 - antigens, cd34 MeSH D23.050.301.264 ... hiv antigens MeSH D23.050.327.520.300 - hiv core protein p24 MeSH D23.050.327.520.330 - hiv envelope protein gp41 MeSH D23.050. ... antigens, cd30 MeSH D23. - antigens, cd31 MeSH D23. - antigens, cd34 MeSH D23. - ... antigens, cd15 MeSH D23.101.100.900.131 - antigens, cd31 MeSH D23.101.100.920 - antigens, ly MeSH D23.101.100.930 - antigens, ...
These proteins include fibroblast activating protein and alpha-smooth muscle actin. Furthermore, TACs secrete many pro- ... They also lack the expression of markers CD14, CD34, CD45, which can be important in the ability of stromal cells to remain ... Low levels of human leukocyte antigen (HLA-DR) make MSC's hypoimmunogenic. MSC's have trilineage differentiation where they are ... Protein & Cell. 8 (7): 501-513. doi:10.1007/s13238-017-0398-2. ISSN 1674-800X. PMC 5498339. PMID 28364278. Park, Chae Woon; Kim ...
It is considered a major marker of HSC pluripotency in concordance with CD34. In human HSCs, Thy1 cells are all CD34 positive. ... It was originally named theta (θ) antigen, then Thy-1 (THYmocyte differentiation antigen 1) due to its prior identification in ... The 25-kDa core protein (excluding the heavy glycosylation) of rodent Thy-1 is 111 or 112 amino acids in length, and is N- ... The antigen Thy-1 was the first T cell marker to be identified. Thy-1 was discovered by Reif and Allen in 1964 during a search ...
The αIIbβ3 integrin and GPIb-V-IX complex identify distinct stages in the maturation of CD34+cord blood cells to megakaryocytes ... In the resting state the contact between the two protein subunits (necessary for the complex activation) is prevented by ... Glycoprotein V: the predominant target antigen in gold-induced autoimmune thrombocytopenia. Blood. 2002. ISSN 1528-0020. DOI: ... Thrombin binding to its receptor activates protein kinase C and increases the level of inositol triphosphate. Consequently, ...
The ability of T cells to recognize foreign antigens is mediated by the T cell receptor (TCR), which is a surface protein able ... Still during the double negative stage, CD34 expression stops and CD1 is expressed. Expression of both CD4 and CD8 makes them ... a protein which drives apoptosis. Cells which do not have a high affinity for self-antigens survive negative selection. At this ... This allows single positive thymocytes to be exposed to a more complex set of self-antigens than is present in the cortex, and ...
In T cells, IL-4 down-regulates the expression of VLA-4. In CD34 positive cells, IL-3 and SCF cause up-regulation, and G-CSF ... Integrin α4β1 (very late antigen-4) is an integrin dimer. It is composed of CD49d (alpha 4) and CD29 (beta 1). The alpha 4 ... so that pathogenic T-cells are unable to enter the brain and thus unable to attack myelin protein. It has been found that in ... Chigaev A, Wu Y, Williams DB, Smagley Y, Sklar LA (February 2011). "Discovery of very late antigen-4 (VLA-4, alpha4beta1 ...
Wang Y, Yang J, Zheng H, Tomasek GJ, Zhang P, McKeever PE, Lee EY, Zhu Y (June 2009). "Expression of mutant p53 proteins ... Bonnet and Dick isolated a subpopulation of leukemia cells that expressed surface marker CD34, but not CD38. The authors ... stage-specific embryonic antigen-1), EGFR and CD44. The use of CD133 for identification of brain tumor stem-like cells may be ... The AC133 epitope, but not the CD133 protein, is specifically expressed in colon CSCs and its expression is lost upon ...
Felschow DM, McVeigh ML, Hoehn GT, Civin CI, Fackler MJ (June 2001). "The adapter protein CrkL associates with CD34". Blood. 97 ... a novel Cas-like docking protein, in a cytoskeleton-dependent signaling pathway initiated by ligation of integrin or antigen ... Crk-like protein is a protein that in humans is encoded by the CRKL gene. v-CRK avian sarcoma virus CT10-homolog-like contains ... Shi CS, Tuscano J, Kehrl JH (February 2000). "Adaptor proteins CRK and CRKL associate with the serine/threonine protein kinase ...
Surfactant protein A (SP-A) Surfactant protein D (SP-D) CL-L1 CL-P1 CL-K1 Peptidoglycan recognition proteins (PGRPs) PGLYRP1 ... Antigen Antigenicity Immunogen Superantigen Allergen Hapten Epitope Linear Conformational Mimotope Tumor antigen Antigen- ... SLAMF9 Cadherins Selectins E-selectin L-selectin P-selectin Others Lymphocyte homing receptors CD34 GLYCAM-1 Addressin (MAdCAM- ... Royet J, Gupta D, Dziarski R (December 2011). "Peptidoglycan recognition proteins: modulators of the microbiome and ...
... using the genetic material encoding reprogramming protein factors, recombinant proteins; microRNA, a synthetic, self- ... DC-like antigen-presenting cells obtained from human induced pluripotent stem cells can serve as a source for vaccination ... Red blood cells (RBC)s generated in vitro from mobilized CD34 positive cells have normal survival when transfused into an ... CCAAT/enhancer binding protein-α (C/EBPα) induces transdifferentiation of B cells into macrophages at high efficiencies and ...
... s typically express vimentin, cytokeratins, epithelial membrane antigen, and CD34, whereas they are usually ... Exportin 1 (a.k.a. XPO1 or CRM1) is a nuclear export protein responsible for the export of over 200 proteins, including the ... Two of these inhibitory proteins that have been studied recently are CTLA-4 and PD1, and drugs targeting these proteins are in ... a subclass of protein kinases) is an enzyme that transfers a phosphate group from an ATP molecule to a protein in a cell. It ...
Transmigration of the leukocyte occurs as PECAM proteins, found on the leukocyte and endothelial cell surfaces, interact and ... MadCAM-1 and CD34 as ligands. Suppressed expression of some selectins results in a slower immune response. If L-selectin is not ... and is independent of specific cellular antigens. Cytokines released in the initial immune response induce vasodilation and ... a platelet alpha-granule membrane protein, is also synthesized by vascular endothelial cells and is localized in Weibel-Palade ...
... is a heavily O-glycosylated transmembrane protein that is encoded by the CD99 gene in humans. The protein has a mass of 32 kD. ... Gelin C, Aubrit F, Phalipon A, Raynal B, Cole S, Kaczorek M, Bernard A (1989). "The E2 antigen, a 32 kd glycoprotein involved ... and CD34". J. Cutan. Pathol. 30 (10): 631-6. doi:10.1034/j.1600-0560.2003.00126.x. PMID 14744088. S2CID 37152987. Cerisano V, ... "CD99 monoclonal antibody induce homotypic adhesion of Jurkat cells through protein tyrosine kinase and protein kinase C- ...
Core histone macro-H2A.1 is a protein that in humans is encoded by the H2AFY gene. Histones are basic nuclear proteins that are ... "Novel tumor antigens identified by autologous antibody screening of childhood medulloblastoma cDNA libraries". International ... "Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient ... Takahashi I, Kameoka Y, Hashimoto K (Aug 2002). "MacroH2A1.2 binds the nuclear protein Spop". Biochimica et Biophysica Acta ( ...
The Duffy antigen binding protein in P. vivax is composed of three subdomains and is thought to function as a dimer. The ... Duffy antigen receptor for chemokines, von Willebrand factor, CD31, CD34, CD105 and CD146". J. Pathol. 206 (3): 260-8. doi: ... DARC+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH) Duffy at BGMUT Blood Group Antigen ... Recent work has identified a number of additional roles for this protein. On erythrocytes, the Duffy antigen acts as a receptor ...
Mijelin protein nula • Osteonektin • Protein C • Protein S • Proteoglikan • Serum amiloid P komponenta • Sialoglikoprotein ( ... CD34 • CD35 • CD36 • CD37 • CD38 • CD39 • CD40 • CD41 • CD42 (a, b, c, d) • CD43 • CD44 • CD45 • CD46 • CD47 • CD48 • CD49 (a, ... 2000). "Characterization of a new member of the TNF family expressed on antigen presenting cells.". Biol. Chem. 380 (12): 1443- ... Faktor aktivacije B-ćelija, (BAFF) koji je takođe poznat kao faktor nekroze tumora ligand superfamilija član 13B, je protein ...
I. Partial characterization of soluble Ki-1 antigen and detection of the antigen in cell culture supernatants and in serum by ... CD30, also known as TNFRSF8, is a cell membrane protein of the tumor necrosis factor receptor family and tumor marker. ... Josimovic-Alasevic O, Dürkop H, Schwarting R, Backé E, Stein H, Diamantstein T (Jan 1989). "Ki-1 (CD30) antigen is released by ... Shiota M, Fujimoto J, Semba T, Satoh H, Yamamoto T, Mori S (Jun 1994). "Hyperphosphorylation of a novel 80 kDa protein-tyrosine ...
protein binding. • calcium ion binding. • metal ion binding. Cellular component. • integral component of membrane. • membrane. ... Macrophage-1 antigen (CD11b+CD18). *VLA-4 (CD49d+CD29). *Glycoprotein IIb/IIIa (ITGA2B+ITGB3) ... an EGF-like domain and a complement-binding protein-like domains (same as complement regulatory proteins: CRP) having short ... calcium-dependent protein binding. • glycosphingolipid binding. • fucose binding. • carbohydrate binding. • sialic acid binding ...
Seligman P. A., Butler C. D., Massey E. J., etal. The p97 antigen is mapped to the q24-qter region of chromosome 3; the same ... C-terminal protein lipidation. • Посттрансляционная модификация. • метаболизм клеточных белков. • transport. • iron ion ... Le Beau M. M., Diaz M. O., Plowman G. D., etal. Chromosomal sublocalization of the human p97 melanoma antigen. (англ.) // Hum. ... Plowman G. D., Brown J. P., Enns C. A., etal. Assignment of the gene for human melanoma-associated antigen p97 to chromosome 3 ...
2001). "Heterogeneous RNA-binding protein M4 is a receptor for carcinoembryonic antigen in Kupffer cells". J. Biol. Chem. 276 ( ... protein homodimerization activity. • identical protein binding. Cellular component. • anchored component of membrane. • ... This membrane protein-related article is a stub. You can help Wikipedia by expanding it.. *v ... Carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5) also known as CD66e (Cluster of Differentiation 66e), is a ...
The protein also carries the Jr(a) antigen, which defines the Junior blood group system.[9] ... Click on genes, proteins and metabolites below to link to respective articles.[§ 1] [[File:. ... protein homodimerization activity. • transporter activity. • ATPase activity. • GO:0001948 protein binding. • ATP binding. • ... Click on genes, proteins and metabolites below to link to respective articles. [§ 1] [[File:. ...
van Rhenen A., van Dongen G. A., Kelder A., et al. The novel AML stem cell associated antigen CLL-1 aids in discrimination ... англ.) // Proteins : journal. - 2003. - Vol. 53, no. 1. - P. 44-55. - DOI:10.1002/prot.10440. - PMID 12945048. ...
protein binding. • ankyrin binding. • gamma-catenin binding. • beta-catenin binding. • GTPase activating protein binding. • ... "Interaction of glycogen synthase kinase 3beta with the DF3/MUC1 carcinoma-associated antigen and beta-catenin". Molecular and ... Oneyama C, Nakano H, Sharma SV (March 2002). "UCS15A, a novel small molecule, SH3 domain-mediated protein-protein interaction ... Several proteins such as SNAI1/SNAIL,[58][59] ZFHX1B/SIP1,[60] SNAI2/SLUG,[61][62] TWIST1[63] and DeltaEF1[64] have been found ...
This protein belongs to family A of G protein-coupled receptor superfamily. The gene is preferentially expressed by immature ... Ebert LM, McColl SR (2002). "Up-regulation of CCR5 and CCR6 on distinct subpopulations of antigen-activated CD4+ T lymphocytes ... protein binding. • C-C chemokine receptor activity. • C-C chemokine binding. Cellular component. • integral component of ... Chemokine receptor 6 also known as CCR6 is a CC chemokine receptor protein which in humans is encoded by the CCR6 gene.[5] CCR6 ...
It is also called Lewis x and SSEA-1 (stage-specific embryonic antigen 1) and represents a marker for murine pluripotent stem ... Proteins: clusters of differentiation (see also list of human clusters of differentiation) ... CD15 Antigen at the US National Library of Medicine Medical Subject Headings (MeSH) ... CD15 (3-fucosyl-N-acetyl-lactosamine) is a cluster of differentiation antigen - an immunologically significant molecule. CD15 ...
antigen binding. • transmembrane signaling receptor activity. • MHC class II protein binding. Cellular component. • membrane. • ... Protein[edit]. The LAG3 protein, which belongs to immunoglobulin (Ig) superfamily, comprises a 503-amino acid type I ... A new ligand for human leukocyte antigen class II antigens". The Journal of Experimental Medicine. 176 (2): 327-37. doi:10.1084 ... A new ligand for human leukocyte antigen class II antigens". The Journal of Experimental Medicine. 176 (2): 327-37. doi:10.1084 ...
... antigen je protein koji je kod ljudi kodiran CD97 genom.[1][2][3] ... CD34 • CD35 • CD36 • CD37 • CD38 • CD39 • CD40 • CD41 • CD42 (a, b, c, d) • CD43 • CD44 • CD45 • CD46 • CD47 • CD48 • CD49 (a, ... 2001). "Molecular analysis of the epidermal growth factor-like short consensus repeat domain-mediated protein-protein ... aktivnost G-protein spregnutog receptora. • vezivanje jona kalcijuma. Celularna komponenta. • ekstracelularni prostor. • ...
GO:0001948 protein binding. • identical protein binding. • enzyme binding. • cell adhesion molecule binding. • neuregulin ... "Entrez Gene: ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)".. *^ May, K. E.; Villar, J.; Kirtley, S.; ... The ITGB3 protein product is the integrin beta chain beta 3. Integrins are integral cell-surface proteins composed of an alpha ... Integrin beta-3 (β3) or CD61 is a protein that in humans is encoded by the ITGB3 gene.[5] CD61 is a cluster of differentiation ...
identical protein binding. • peptidase activity. • hydrolase activity. • virus receptor activity. • protein homodimerization ... "Direct association of adenosine deaminase with a T cell activation antigen, CD26". Science. 261 (5120): 466-9. doi:10.1126/ ... The protein encoded by the DPP4 gene is an antigenic enzyme expressed on the surface of most cell types and is associated with ... protein binding. • serine-type endopeptidase activity. Cellular component. • lamellipodium membrane. • extracellular exosome. • ...
It binds to CD40 (protein) on antigen-presenting cells (APC), which leads to many effects depending on the target cell type. In ... protein binding. Cellular component. • integral component of membrane. • membrane. • plasma membrane. • integral component of ... CD154, also called CD40 ligand or CD40L, is a protein that is primarily expressed on activated T cells[5] and is a member of ... B cells can present antigens to a specialized group of helper T cells called TFH cells. If an activated TFH cell recognizes the ...
Other proteins with elevated expression in the lung are the dynein protein DNAH5 in ciliated cells, and the secreted SCGB1A1 ... and dendritic cells which present antigens to activate components of the adaptive immune system such as T-cells and B-cells.[51 ... "In vitro generation of type-II pneumocytes can be initiated in human CD34(+) stem cells". Biotechnology Letters. 38 (2): 237- ... The highest expression of lung specific proteins are different surfactant proteins,[18] such as SFTPA1, SFTPB and SFTPC, and ...
Primarily, the VCAM-1 protein is an endothelial ligand for VLA-4 (Very Late Antigen-4 or integrin α4β1) of the β1 subfamily of ... Vascular cell adhesion protein 1 also known as vascular cell adhesion molecule 1 (VCAM-1) or cluster of differentiation 106 ( ... The VCAM-1 protein mediates the adhesion of lymphocytes, monocytes, eosinophils, and basophils to vascular endothelium. It also ... Proteins: clusters of differentiation (see also list of human clusters of differentiation) ...
G-protein coupled receptor signaling pathway. • lymph node development. • Иммунный ответ. • передача сигнала. • leukocyte ... uveitis antigens induce CXCR3- and CXCR5-expressing lymphocytes and immature dendritic cells to migrate (англ.) // Blood (англ ... G-protein coupled receptor activity. • связывание с белками плазмы. • signal transducer activity. • C-C chemokine receptor ... Dobner T., Wolf I., Emrich T., Lipp M. Differentiation-specific expression of a novel G protein-coupled receptor from Burkitt's ...
2% of the protein is wound into α-helices and 46% into β-sheets, with the remaining 52% of the molecules remaining in the loop ... In addition to aiding with cytotoxic T cell antigen interactions the CD8 co-receptor also plays a role in T cell signaling. The ... Like the TCR, CD8 binds to a major histocompatibility complex (MHC) molecule, but is specific for the MHC class I protein.[1] ... There are two isoforms of the protein, alpha and beta, each encoded by a different gene. In humans, both genes are located on ...
antigen binding. • virus receptor activity. • protein binding. • transmembrane signaling receptor activity. • identical protein ... This membrane protein-related article is a stub. You can help Wikipedia by expanding it.. *v ... Signaling lymphocytic activation molecule 1 is a protein that in humans is encoded by the SLAMF1 gene.[5][6] Recently SLAMF1 ... Proteins: clusters of differentiation (see also list of human clusters of differentiation) ...
CD34 • CD35 • CD36 • CD37 • CD38 • CD39 • CD40 • CD41 • CD42 (a, b, c, d) • CD43 • CD44 • CD45 • CD46 • CD47 • CD48 • CD49 (a, ... C5a receptor (receptor 1 komplementne komponente 5a, C5AR1, CD88, klaster diferencijacije 88) je G protein spregnuti receptor ... 1996). "CD88 antibodies specifically bind to C5aR on dermal CD117+ and CD14+ cells and react with a desmosomal antigen in human ... signalni put G-protein spregnutog receptora. • aktivacija fosfolipaze C. • elevacija koncentracije jona citosolnog kalcijuma. • ...
... jer dio njih je pozitivan za CD34 antigen. Klasični mastocitni markeri uključuju visoku sklonost za IgE receptor, CD117 (c-Kit ... Aktivira protein-kinazu C Protein-kinaza C. Aktivira pokretanje fosforilacije granula miozinskog lahkog lanca koje rastavljaju ... Antigen unakrsno povezuje molekule FcεR1 i Lyn-tirozin kinazu, u citoplazmi fosforilira u ITAM i b i g FcεR1 lanac. Nakon ... septembar 2002). "Macromolecular protein signaling complexes and mast cell responses: a view of the organization of IgE- ...
... cDNA clone for the human invariant gamma chain of class II histocompatibility antigens and its implications for the protein ... CD74 (англ. HLA class II histocompatibility antigen gamma chain; HLA-DR antigens-associated invariant chain) - мембранный белок ... II histocompatibility antigen gamma chaingamma chain of class II antigensIiHLA-DR antigens-associated invariant chainIa antigen ... Riberdy J.M., Newcomb J.R., Surman M.J., Barbosa J.A., Cresswell P. HLA-DR molecules from an antigen-processing mutant cell ...
1997). "The Oka blood group antigen is a marker for the M6 leukocyte activation antigen, the human homolog of OX-47 antigen, ... is a protein that in humans is encoded by the BSG gene.[5][6][7] This protein is a determinant for the Ok blood group system. ... protein binding involved in cell-cell adhesion. Cellular component. • integral component of membrane. • membrane. • focal ... protein localization to plasma membrane. • homophilic cell adhesion via plasma membrane adhesion molecules. • axon guidance. • ...
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley- ... CD34 • CD35 • CD36 • CD37 • CD38 • CD39 • CD40 • CD41 • CD42 (a, b, c, d) • CD43 • CD44 • CD45 • CD46 • CD47 • CD48 • CD49 (a, ... 1991). „Expression of the YB5.B8 antigen (c-kit proto-oncogene product) in normal human bone marrow". Blood. 78 (1): 30-7. PMID ... Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley- ...
Ewing R. M., Chu P., Elisma F. et al. Large-scale mapping of human protein-protein interactions by mass spectrometry (англ.) ... Tissue Antigens (англ.)русск. : journal. - 2007. - Vol. 68, no. 6. - P. 509-517. - DOI:10.1111/j.1399-0039.2006.00726.x. - PMID ... Protein structure and conformations of the pure (Na+ +K+)-ATPase (англ.) // Biochim. Biophys. Acta (англ.)русск. : journal. - ... protein stabilization. • ion transport. • cellular potassium ion homeostasis. • potassium ion transport. • membrane ...
T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell. • T cell antigen ... CD34 · CD35 · CD36 · CD37 · CD38 · CD39 · CD40 · CD41 · CD42 (a, b, c, d) · CD43 · CD44 · CD45 · CD46 · CD47 · CD48 · CD49 (a, ... protein binding. Компонент клетки. • immunological synapse. • extracellular space. • plasma membrane. • integral component of ...
"The CD4 and CD8 antigens are coupled to a protein-tyrosine kinase (p56lck) that phosphorylates the CD3 complex". Proceedings of ... MHC class II protein binding. • identical protein binding. • protein tyrosine kinase binding. • signaling receptor activity. • ... CD4 has also been shown to interact with SPG21,[9] Lck[10][11][12][13][14] and Protein unc-119 homolog.[15] ... enzyme linked receptor protein signaling pathway. • entry into host cell. • T cell activation. • positive regulation of T cell ...
... cells express endothelial protein C receptor (EPCR/CD201/PROCR) when exposed to the hematopoietic stem cell (HSC) self-renewal ... A small subset of human cord blood CD34,sup,+,/sup, ... Antigens, CD / analysis* * Antigens, CD34 / analysis* * Cell ... A small subset of human cord blood CD34+ cells express endothelial protein C receptor (EPCR/CD201/PROCR) when exposed to the ... EPCR expression marks UM171-expanded CD34 + cord blood stem cells Blood. 2017 Jun 22;129(25):3344-3351. doi: 10.1182/blood-2016 ...
... lines or clones that are specifically generated against leukemic antigen-presenting cells from the patient, may separate ... Fusion Proteins, bcr-abl / biosynthesis* * Fusion Proteins, bcr-abl / genetics* * Fusion Proteins, bcr-abl / immunology ... Generation of dendritic cells expressing bcr-abl from CD34-positive chronic myeloid leukemia precursor cells Hum Immunol. 1997 ... In this report we demonstrate that after culturing CD34-positive cells purified from bone marrow of patients with chronic phase ...
Ab182830 is a protein fragment produced in Escherichia coli and has been validated in SDS-PAGE. Abcam provides free… ... CD34 molecule. *CD34_HUMAN. *Cluster designation 34. *Hematopoietic progenitor cell antigen CD34 ... Proteins and Peptides. Proteomics tools. Agonists, activators, antagonists and inhibitors. Lysates. Multiplex miRNA assays. By ... The Universal Protein Resource (UniProt) in 2010. Nucleic Acids Res. 38:D142-D148 (2010) . ...
Rat Monoclonal Anti-CD34 Antibody (MEC 14.7) [FITC]. Hematopoietic Stem Cell Marker. Validated: ELISA, Flow, ICC/IF, IHC-Fr, ... hematopoietic progenitor cell antigen). CD34 is a cell-surface glycoprotein type 1 transmembrane protein that belongs to the ... Alternate Names for CD34 Antibody (MEC 14.7) [FITC]. *CD34 antigenhematopoietic progenitor cell antigen CD34 ... CD34 Serves as an Important Marker in Disease Research. CD34 is a membrane protein that aids cells in cell-cell adhesion. ...
Mouse Monoclonal Anti-CD34 Antibody (QBEnd/10) [Biotin]. Hematopoietic Stem Cell & Endothelial Marker. Validated: WB, ICC/IF, ... hematopoietic progenitor cell antigen). CD34 is a cell-surface glycoprotein type 1 transmembrane protein that belongs to the ... Alternate Names for CD34 Antibody (QBEnd/10) [Biotin]. *CD34 antigenhematopoietic progenitor cell antigen CD34 ... CD34 Serves as an Important Marker in Disease Research. CD34 is a membrane protein that aids cells in cell-cell adhesion. ...
Rat Monoclonal CD34 antibody [MEC14.7] (Low endotoxin, azide free). Validated in ICC/IF, IHC-P, FACS, IP, IHC. Tested in Human ... Pamphlet - Recombinant Active Proteins Download the latest version of GeneTexs Recombinant Active Proteins Pamphlet. ... Antigen Species Mouse Immunogen T-end.1, a pMT transformed endothelial cell line. ... There are currently no reviews for CD34 antibody [MEC14.7] (Low endotoxin, azide free) (GTX42057). Be the first to share your ...
Rat Monoclonal CD34 antibody [MEC14.7] (FITC). Validated in ICC/IF, FACS, IHC. Tested in Human, Mouse. Cited in 7 reference(s ... Protein G purified. From tissue culture supernatant Conjugation Fluorescein isothiocyanate (FITC). Note For laboratory use only ... Antigen Species Mouse Immunogen T-end.1, a pMT transformed endothelial cell line. ... FACS analysis of mouse bone marrow cells using GTX75411 CD34 antibody [MEC14.7] (FITC).. ...
Invitrogen Anti-CD34 Monoclonal (4H11), eBioscience , Catalog # 12-0349-42. Tested in Flow Cytometry (Flow) applications. This ... Protein Aliases: CD34; CD34 antigen; Hematopoietic progenitor cell antigen CD34; Mucosialin; RP11-328D5.2 ... CD34 - HSC), LSK CD34 + Flt3 - (CD34 + HSC), and LSK CD34 + Flt3 + (MPP) prepared from BM of adult mice (8-week-old) ( n = 3). ... The intracellular chain of the CD34 antigen is a site of phosphorylation by activated protein kinase C suggesting a putative ...
Invitrogen Anti-CD34 Monoclonal (4H11), eBioscience™, Catalog # 47-0349-42. Tested in Flow Cytometry (Flow) applications. This ... Protein Aliases: CD34; CD34 antigen; Hematopoietic progenitor cell antigen CD34; Mucosialin; RP11-328D5.2 ... The intracellular chain of the CD34 antigen is a site of phosphorylation by activated protein kinase C suggesting a putative ... Day 10 cultures were stained for both CD34 and CD43 (E) and CD43 + /CD34 - , CD43 + /CD34 + double-positive, and CD43 - CD34 - ...
CD34 protein is involved in differentiating HPCs into certain types of neurons. Also useful for studying endothelial cells, ... Research proven mouse monoclonal CD34 antibody. Excellent marker for hematopoietic progenitors and stem cells. ... CD34 may also stimulate proportions of adult human HSCs to differentiate into full-fledged neurons. This may open new ... In tumors, CD34 is found in alveolar soft part sarcoma, preB-ALL (positive in 75%), AML (40%), AML-M7 (most), ...
0 (AC133 Antigen); 0 (Antigens, CD34); 0 (Biomarkers); 0 (PROM1 protein, human); 0 (Thy-1 Antigens). ... 0 (Homeodomain Proteins); 0 (Immunoglobulin lambda-Chains); 0 (Integrin alpha2); 0 (Thy-1 Antigens); 128559-51-3 (RAG-1 protein ... 0 (CD146 Antigen); 0 (MCAM protein, human); 0 (Thy-1 Antigens); 8L70Q75FXE (Adenosine Triphosphate). ... 0 (Biomarkers); 0 (ENG protein, human); 0 (Endoglin); 0 (GPI-Linked Proteins); 0 (Thy-1 Antigens); EC (5-Nucleotidase ...
0/Antigens, CD34; 0/Lectins; 0/Neoplasm Proteins; 0/Plant Lectins; 0/Ulex europaeus lectins; 0/Vimentin; 0/von Willebrand ... and CD 34, but not against keratin, epithelial membrane antigen (EMA) or S-100 protein (S100). The proliferating cell nuclear ... Antigens, CD34 / analysis. Female. Hemangioendothelioma, Epithelioid / chemistry, pathology*, surgery. Humans. Lectins / ... Neoplasm Proteins / analysis. Neoplasms, Vascular Tissue / chemistry, pathology*, surgery. Plant Lectins*. Vimentin / analysis ...
Home > Protein > CD34 human. mouse. rat. New Protein Search:. Hematopoietic progenitor cell antigen CD34 ... Protein Mutation Frequency in Cancer. The lollipop plot above illustrates recurrent (observed in 3 or more out of 4440 TCGA ...
CD34. Hematopoietic progenitor cell antigen CD34 also known as CD34 antigen is a protein that in humans is encoded by the CD34 ... The CD34 protein is a member of a family of single-pass transmembrane sialomucin proteins that show expression on early ... "Activated protein kinase C directly phosphorylates the CD34 antigen on hematopoietic cells". The Journal of Biological ... CD34 CD34 molecule".. *^ Simmons DL, Satterthwaite AB, Tenen DG, Seed B (Jan 1992). "Molecular cloning of a cDNA encoding CD34 ...
Apoptosis and proliferation in thyroid carcinoma: correlation with bcl-2 and p53 protein expression. Br J Cancer. 1997; 75: 537 ... Density of the microvessels was being evaluated basing on the expression of the antigen CD34 and CD105. Evaluation of the ... Microtissue density prognostic factor evaluation based on antigens CD34 and CD 105 in ovarian cancer patients ... The subject of this publication is to find the answer to a question whether the practical usage of the CD34 and CD 105 as a ...
RMA-0504), CD34 (cat no. Kit-0004), latent membrane protein 1 (cat no. MAB-0063), ALK receptor tyrosine kinase (cat no. MAB- ... latent membrane protein 1; ALK, ALK tyrosine kinase receptor; EMA, epithelial membrane antigen; SMA, smooth muscle actin; EBER ... Antigen retrieval was performed through heating the tissue sections in 10 mM sodium citrate buffer for 10 min. Following ... i] Ki-67 protein is a cellular marker for proliferation; D2-40 is a marker of lymphatic endothelial cells, reflecting micro ...
... epithelial membrane antigen (17 [85%]); CD34 (9 [45%]); CD99 (5 [25%]); muscle markers, either desmin or alpha-smooth muscle ... actin (3 [15%]), other markers such as S-100 protein, neurofilament, neuron-specific enolase, synaptophysin and CD56 (12 [60 ...
pfam06365, CD34_antigen, CD34 antigen protein. 120. 2e-06. 24% (38/156). CD34_antigen. 8. ... Flocculation protein FLO5 precursor related cluster. 2874. 0.0. 54% (591/1075). 1. GO:0000128,flocculation,IEA; GO:0000501, ... pfam05792, Candida_ALS, Candida agglutinin-like protein (ALS). 566. 5e-58. 24% (202/822). Candida_ALS. 2. ... pfam05424, Duffy_binding, Plasmodium Duffy binding protein. 124. 8e-07. 19% (64/325). Duffy_binding. 9. ...
"Activated protein kinase C directly phosphorylates the CD34 antigen on hematopoietic cells". The Journal of Biological ... Antigens,+CD34 at the US National Library of Medicine Medical Subject Headings (MeSH) Mouse CD Antigen Chart Human CD Antigen ... CD34 is a transmembrane phosphoglycoprotein protein encoded by the CD34 gene in humans, mice, rats and other species. CD34 ... The CD34 protein is a member of a family of single-pass transmembrane sialomucin proteins that show expression on early ...
... recombinant protein with GST-tag at N-terminal. (H00000947-P01) - Products - Abnova ... Human CD34 full-length ORF ( NP_001764.1, 1 a.a. - 328 a.a.) ... CD34 is a monomeric cell surface antigen with a molecular mass ... Human CD34 full-length ORF ( NP_001764.1, 1 a.a. - 328 a.a.) recombinant protein with GST-tag at N-terminal. ... Best use within three months from the date of receipt of this protein. ...
Mast cells were immunoreactive for epithelial membrane antigen (EMA) and S-100 protein. Fibroblasts and endothelial cells were ... immunostaining by CD34. MIB-1 was low (inferior to 1%). What is your diagnosis?. FINAL DIAGNOSIS. International Society of ...
A) Splenocytes from mice injected with transduced CD34 were pooled and stimulated ex vivo with MART-1 peptide (1μg/mL) and ... recent study engineered murine HSC to express an HLA-DR4-restricted TCR against the melanoma tyrosine-related protein 1 antigen ... 2011) Chimeric antigen receptor-modified T cells in chronic lymphoid leukemia. N Engl J Med 365:725-733. ... 1A) (33, 34). F5 MART-1 is an improved MART-1-specific TCR displaying enhanced affinity to the antigen and was provided by the ...
Independent of location, most GISTs express the CD34 antigen (70-78%) and the CD117 (72-94%) antigen. The CD34 protein is a ... hematopoietic progenitor cell antigen that occurs in a variety of mesenchymal tumors. CD117 also is known as the c-kit protein ... restrictive and use the term when specifically referring to GI mesenchymal tumors that express the CD117 and/or CD34 antigen. ... differences in clinical outcome and expression of multidrug resistance proteins. J Clin Oncol. 2000 Sep 15. 18(18):3211-20. [ ...
Malignant fibrous histiocytoma MFH is a soft-tissue sarcoma originating from fibroblast cells characterized by a high rate of metastasis or recurrence This tumor rarely develops in the gastrointestina
Gomes I, Sharma TT, Edassery S, Fulton N, Mar BG, Westbrook CA (Jun 2002). "Novel transcription factors in human CD34 antigen- ... 2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. ... SPT20 homolog is a protein that in humans is encoded by the SUPT20H gene. GRCh38: Ensembl release 89: ENSG00000102710 - Ensembl ... 2006). "p38 and a p38-interacting protein are critical for downregulation of E-cadherin during mouse gastrulation". Cell. 125 ( ...
Increased expression of Fas antigen on bone marrow CD34+ cells of patients with aplastic anaemia. Br. J. Haematol. 91: 245. ... Bone marrow-derived CD34+ cells were incubated with IFN-γ or TNF-α, in the presence or absence of SB203580, and the induction ... B, The blot shown in A was probed with an Ab against p38β to control for protein loading. C and D, Enriched human progenitors ... E, Isolated bone marrow CD34+ cells were cultured for 4 days in the presence and absence of 1000 IU/ml IFN-γ or 20 ng/ml TNF-α ...
The TRA-1-81 antibody reacts with a 200-240 kD cell surface antigen expressed by human embryonic stem cells (ESC), embryonic ... Antigen Details Structure Mucin-like protein, CD34 family member, 200-240 kD Distribution embryonic stem cells (ESC), embryonic ... Antigen References 1. Andrews PW, et al. 1984. Hybridoma. 3:347.. 2. Schopperle WM and Dewolf WC. 2007. Stem Cells. 25:723.. 3 ... The TRA-1-81 antibody reacts with a 200-240 kD cell surface antigen expressed by human embryonic stem cells (ESC), embryonic ...
CD34 (Hematopoietic Stem Cell & Endothelial Marker) Antibody - With BSA and Azide, Mouse Monoclonal Antibody [Clone SPM123 ] ... Hematopoietic progenitor cell antigen CD34, CD34, CD34. Format 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A ... Protein Information. Name CD34. Function Possible adhesion molecule with a role in early hematopoiesis by mediating the ... This MAb recognizes a single chain, transmembrane, heavily glycosylated protein of 90-120kDa, which is identified as CD34. On ...
Cells were stained for individual antigens and analyzed by flow cytometry.. Quantitation of intracellular proteins by flow ... MSCs were checked for positivity of CD105, CD73, and CD90 and the lack of expression of CD45 and CD34.30 The purity of MSC ... Equal amounts of protein lysate were separated by SDS-PAGE (12% gel) for 2 hours at 80 V. Proteins were transferred to ... On the other hand, p53 has been reported to promote proteasomal degradation of HIF-1α protein.40 To investigate a possible role ...
It is often characterized by CD34 antigen negativity with a bright expression of CD33 and monocytic differentiation. NPM1 ... TP53 protein is a transcription factor and tumor suppressor gene that determines whether the cell undergoes repair, senescence ... loss of HLA-DR and CD34 antigen negativity, and impaired survival (26). AML patients with FLT3-ITD mutation appear to benefit ... CCAAT Enhancer Binding Protein-alpha (CEBPA) is a transcription factor responsible for promoting granulocytic maturation in ...
  • There are currently no images for CD34 Antibody (NB600-1071F). (
  • This CD34 (MEC 14.7) antibody is useful for Immunohistochemistry (on both paraffin-embedded and frozen sections), Flow Cytometry, Immunocytochemistry/Immunofluorescence, Western blot, Immunoprecipitation and ELISA. (
  • This antibody does not detect Human CD34 and is an execellent tool for marking host derived endothelial cells/vasculature in human cancer xenografts on mouse. (
  • CD34 Antibody MEC 14.7 (NB600-1071) is a useful reagent for identification and characterization of capillary endothelial cells. (
  • FACS analysis of WEH1 cells using GTX42057 CD34 antibody [MEC14.7] (Low endotoxin, azide free). (
  • There are currently no reviews for CD34 antibody [MEC14.7] (Low endotoxin, azide free) (GTX42057) . (
  • FACS analysis of mouse bone marrow cells using GTX75411 CD34 antibody [MEC14.7] (FITC). (
  • The following product was used in this experiment: CD34 Monoclonal Antibody (4H11), PE, eBioscience from Thermo Fisher Scientific, catalog # 12-0349-42, RRID AB_1548680. (
  • Description: The 4H11 monoclonal antibody reacts with human CD34, also known as mucosialin. (
  • According to this analysis, the 4H11 antibody belongs to class III, indicating that it reacts with a protein epitope. (
  • The TRA-1-81 antibody reacts with a 200-240 kD cell surface antigen expressed by human embryonic stem cells (ESC), embryonic germ cells (EG), and embryonal carcinoma cells. (
  • Each antibody is crafted with care according to rigorous protocols for immunogen design and preparation, presentation to host animal, and high-affinity purification against the antigen. (
  • Both series of hybrid clones were analyzed with respect to the retention of the enzyme glucose-6-phosphate dehydrogenase and the surface antigen MIC2 identified by monoclonal antibody 12E7, two human X chromosome-linked markers located at opposite ends of the X chromosome. (
  • In order to compare the epitope specificity of an antibody, the clone being used is compared with other known clones recognizing the same antigen in a competition assay. (
  • Cells were incubated with an excess of purified unconjugated CD34 (REA383) antibody followed by staining with fluorochrome-conjugated antibodies of other known clones against the same marker. (
  • As a control, CD34 antibody staining was omitted and cells were measured in the same channels. (
  • The antibody recognizes the class III CD34 epitope resistant to neuraminidase, chymopapain and glycoprotease. (
  • Krauter J, Hartl M, Hambach L, Kohlenberg A, Gunsilius E, Ganser A, Heil G: Receptor-mediated endocytosis of CD34 on hematopoietic cells after stimulation with the monoclonal antibody anti-HPCA-1. (
  • 3. The system of claim 1 , wherein the ligands include at least one of the group consisting of: a protein, an antibody, a chemical composition, and mixtures thereof. (
  • To determine the effect of the non-synonymous SNP 538G>A (G180R) on the ABCC11 in vivo, we generated transiently ABCC11-expressing transgenic mice with adenovirus vector, and examined the protein levels of each ABCC11 in the mice with immunoblotting using an anti-ABCC11 antibody we have generated in the present study. (
  • Here, we used a technology based on size exclusion chromatography followed by immunoprecipitation of target proteins with an antibody bead array (Size Exclusion Chromatography-Microsphere-based Affinity Proteomics, SEC-MAP) to detect hundreds of proteins from a single sample. (
  • On immunohistochemical study, tumor cells exhibited characteristics of mesenchymal and endothelial origin, i.e., strong to moderate immune reactivity against vimentin, factor VIII-related antigen (F8RA), Ulex europaeus agglutinin type 1 lectin (UEA-1), and CD 34, but not against keratin, epithelial membrane antigen (EMA) or S-100 protein (S100). (
  • Mast cells were immunoreactive for epithelial membrane antigen (EMA) and S-100 protein. (
  • All tumors expressed epithelial membrane antigen and were negative for S100 protein. (
  • In contrast focally positive or negative staining was shown for the epithelial membrane antigen (EMA) and CD 99. (
  • Two cases were epithelial membrane antigen and CD99-positive. (
  • These included surfactant protein B (SP-B), thyroid transcription factor-1 (TTF-1), mast cell trypsin, CD68, epithelial antigen markers (high molecular weight cytokeratin, low molecular weight cytokeratin [CK-L], epithelial membrane antigen [EMA], cancer embryonic antigen). (
  • Epithelial membrane antigen - A diagnostic discriminant in surgical pathology: Immunohistochemical profile in epithelial, mesenchymal, and hematopoietic neoplasms using paraffin sections and monoclonal antibodies. (
  • Immunohistochemical markers showed positivity for calretinin and epithelial membrane antigen , and negativity for CD34, CD117, smooth muscle actin, desmin, and S100. (
  • Immunohistochemistry of MPMNs demonstrates positivity for CD56, progesterone receptor, epithelial membrane antigen , and vimentin, which is similar to PPMs. (
  • Immunohistochemical staining (diaminobenzidine x20) showed cells positive for epithelial membrane antigen (b). (
  • In renal cell carcinoma, hepatocellular carcinoma and metastatic adenocarcinoma, epithelial membrane antigen (EMA) is positive but synaptophysin is negative, while in ACC, EMA is negative. (
  • Ber EP4 and epithelial membrane antigen aid distinction of basal cell, squamous cell and basosquamous carcinomas of the skin. (
  • The purpose of this study was to see whether this stain was really 100% positive in BCC in our population, to gain confidence in the use of this immunostain and to encourage the fellow histopathologists to use this stain in difficult cases of epithelial tumors especially in combination with epithelial membrane antigen (EMA). (
  • Immunohistochemical studies--including those with keratin, epithelial membrane antigen , CK5/6, and p63--are usually performed to confirm the epithelial nature of the spindled tumor, but these markers are absent in as many as 30% of cases. (
  • The mediastinal tumor samples taken from our patient stained positively for vimentin, muscle-specific actin, and desmin and were negative for cytokeratin AE 1/3, cytokeratin 7, cytokeratin 20, epithelial membrane antigen (EMA), calretinin, S100 protein, melanoma antibody (HMB45), and leukocyte common antigen. (
  • Since different patterns of glycosylation of the molecule are seen with different cell types, this might explain the wide range of CD34 molecular mass (from 75-85 kDa to 120 kD). (
  • CD34 is possibly an adhesion molecule with a putative role for mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells. (
  • CD34 is also an important adhesion molecule and is required for T cells to enter lymph nodes . (
  • CD34 (CD34 Molecule) is a Protein Coding gene. (
  • 15. The nucleic acid molecule of claim 1, wherein said nucleic acid molecule comprises a nucleotide sequence encoding a chimeric antigen receptor (CAR), wherein said CAR comprises at least one of said co-stimulatory domains. (
  • Additional criteria include trilineage differentiation potential and expression of MSC surface antigens markers CD105 (endoglin), CD73 (ecto-5′-nucleotidase) and CD90 (Thy-1), and lack of expression of hematopoietic markers CD45 (protein tyrosine phosphatase, receptor type, C), CD34 (CD34 molecule) and CD14 (CD14 molecule). (
  • On the basis of differential sensitivity to degradation by specific enzymes, epitopes of monoclonal antibodies to CD34 are classified into three main categories, class I, class II and class III. (
  • The panendotelial antibodies targeted against such markers as CD34 are used most frequently in cancer vessel evaluation. (
  • The second group constitutes the antibodies that agglomerate with the antigens characteristic for proliferous endoepithelial cells. (
  • Check out links to articles that cite our custom service antibodies, peptides, and proteins in major peer-reviewed journals, organized by research category. (
  • These surface antigens were identified initially by monoclonal antibodies and the designations of the antibodies were used often as synonyms for the cell surface proteins they detected, giving rise to a plethora of different names. (
  • CD antigen nomenclature describes different monoclonal antibodies from different sources that recognize identical antigens. (
  • In Hematology the morphological criteria is for the description of specific developmental stages of lymphocytes unlike in CD antigens which the use of monoclonal antibodies allows the objective and precise analysis and standardized typing of mature and immature normal and malignant cells of all hematopoietic cell lineages. (
  • In the last decade the wide palette of monoclonal antibodies has been prepared which recognise of CD antigens on human cells. (
  • Bone marrow cells from C57BL/6 mice were stained with CD34 antibodies and with a suitable counterstaining. (
  • Our bispecific antibodies incorporate a blocking component with weak affinity for CD47, rendering them unable to bind normal cells expressing CD47 alone, and require simultaneous binding to CD20 for high avidity binding to dual antigen-expressing tumor cells. (
  • Such bispecific antibodies targeting CD47 along with tumor-associated antigens may be an effective strategy for selectively eliminating tumor cells that can be broadly applied to cancer. (
  • The antibodies employed were anti-cytokeratin (AE1/3, Dako), anti -cytokeratin (polyclonal wide, Dako), anti-p53 protein (DO-7, Dako) and anti-Ki-67 antigen (MIB-1, Dako). (
  • CD34 expression is a hallmark for identifying pluripotent hematopoietic stem or progenitor cells. (
  • CD34 is a type I transmembrane glycophosphoprotein expressed by hematopoietic stem/progenitor cells (HSCs). (
  • CD34 is a monomeric cell surface antigen with a molecular mass of approximately 110 kD that is selectively expressed on human hematopoietic progenitor cells. (
  • DCs were differentiated either from CD34 � hematopoietic progenitor cells (HPCs) cultured with granulocyte/macrophage colony-stimulating factor (GM-CSF) plus tumor necrosis factor (TNF)- � or from monocytes cultured with GM-CSF plus interleukin 4. (
  • Flow cytometric analysis was used in 1997 by Asahara and colleagues to identify CD34 + KDR + circulating cells as putative endothelial progenitor cells. (
  • It is a leukocyte membrane protein expressed specifically by lymphohematopoietic progenitor cells. (
  • Immunohistochemically, the tumor cells exhibit positivity for vimentin and CD34. (
  • Both mononuclear and bizarre lesional cells expressed strongly and diffusely vimentin and CD34. (
  • However, focal expression of S100, c-KIT, glial fibrillary acidic protein (GFAP), and vimentin can be seen in some tumors (Figure 7, A and B). (
  • Immunohistochemical study showed that all of them were positive for vimentin and negative for S-100 protein, pan-cytokeratin, CD34 and CD31. (
  • Immunohistochemical results showed that these cells are strongly positive for SP-B, TTF-1, CK-L, EMA, and cancer embryonic antigen, whereas polygonal cells, previously also described as round or pale cells, were strongly positive for vimentin and TTF-1, and positive or weakly positive for 2 to 3 kinds of neuro endocrine markers. (
  • CD34 immunohistochemical assessment of angiogenesis as a prognostic marker for prostate cancer recurrence after radical prostatectomy. (
  • Penile SDF-1 protein expression was assessed, in experimental and human diabetic cavernosal samples, by immunohistochemical techniques. (
  • The vascular origin of the neoplasm is confirmed by positive factor VIII-related antigen , CD34, or CD31 immunohistochemical reactions. (
  • A small subset of human cord blood CD34 + cells express endothelial protein C receptor (EPCR/CD201/PROCR) when exposed to the hematopoietic stem cell (HSC) self-renewal agonist UM171. (
  • Fibroblasts and endothelial cells were immunostaining by CD34. (
  • Because these tumors arise from endothelial cells, they usually express factor VIII-related antigen and/or ulex europaeus agglutinin-binding protein. (
  • 2-4) Essential to the diagnosis is the positivity of the epithelioid and dendritic cells to at least one of the endothelial markers, such as factor VIII-related antigen (FVIII-RAg), CD34, and/or CD31, with FVIII-RAg being the most frequent. (
  • CD34 + KDR + cells cultured on fibronectin for seven days express high levels of endothelial antigens such as CD31, Tie-2, and E selectin, and when injected into a mouse in a model of hindlimb ischemia are able to migrate to sites of vascular injury and to target vessels. (
  • 5 However it was later demonstrated that triple positive CD34 + KDR + CD133 + cells do not form endothelial colonies in vitro but do form hematopoietic colonies. (
  • To enhance knowledge for future cellular therapy, we compared the phenotypic, functional and gene expression differences between EPC-derived cells generated from cord blood CD34(+) cells, and lymphatic and macrovascular endothelial cells (EC) isolated from human foreskins and umbilical veins, respectively. (
  • Actin, S100 protein, HMB45 and cytokeratin were negative. (
  • A number of the cases are also positive for CD34, muscle-specific and smooth muscle actins, neuron-specific enolase, and S100 protein ( 8 - 12 ). (
  • 17) Negative reactivity for S100, h-caldesmon, CD34, and glial fibrillary acidic protein help in the differential diagnosis with other types of sarcomas (Table). (
  • Previously published works limited to small case series and case reports used only neurilemmal markers (eg, Leu-7, glial fibrillary acid protein, myelinbasic protein, peripherin), S100 protein, and factor XIIIa (a marker of perineurial fibroblasts) to differentiate these 2 entities. (
  • Evaluation of the microvessel density with CD34 and CD105 markers is not useful in forecasting survival rate and disease recurrence in patients with ovary cancer. (
  • The most commonly know CD antigens are CD4 and CD8 which are markers for T-helper and T-suppressor cells, respectively. (
  • CDla + precursors give rise to cells characterized by the expression of Birbeck granules, the Lag antigen and E-cadherin, three markers specifically expressed on Langerhans cells in the epidermis. (
  • 10 Leukemic stem cells were initially defined phenotypically by specific cell surface markers CD34 + CD38 − and functionally by an ability to initiate leukemia in animal transplant models. (
  • In addition, markers recently developed for PDCs, including CD123 (the interleukin-3 receptor), blood dendritic cell antigen 2 (BDCA2/CD303), (5) and T-cell leukemia/lymphoma 1 (TCL1) and CD2-associated protein (CD2AP), (6) were rarely tested in the literature published prior to 2008. (
  • Despite the fact these two antigens have continued to be used as markers for circulating cells with vascular reparative properties, it was not demonstrated that the infused cells directly formed new blood vessels. (
  • CD34 may serve as a surface receptor that undergoes receptor-mediated endocytosis and regulates adhesion, differentiation and proliferation of hematopoietic stem cells and other progenitors. (
  • [14] [15] Conversely, under other circumstances CD34 has been shown to act as molecular "Teflon" and block mast cell, eosinophil and dendritic cell precursor adhesion, and to facilitate opening of vascular lumina. (
  • The CD Antigen's designation isn't related to the biological function, thus CD antigens include receptors, glycans, adhesion molecules, membrane-bound enzymes, etc. (
  • CACs are further characterized by their morphology, adhesion to fibronectin, and cell surface protein expression. (
  • Structures compatible with Weibel-Palade bodies were also found by electron microscopy.Among them were adhesion molecules, extracellular matrix proteins and cytokines.Our data point to the close lineage relationship of both types of vascular cells and support the theory of a venous origin of the lymphatic system. (
  • Among them were adhesion molecules, extracellular matrix proteins and cytokines. (
  • The anti-CD34 reacts with the largest number of endoepithelial cells. (
  • Flow cytometry analysis (surface staining) of CD34+ cells in human peripheral blood with anti-CD34 (581) purified. (
  • CD34 is a marker of choice for staining blasts in acute myeloid leukemia. (
  • 120 (4):501-11 Enrichment for living murine keratinocytes from the hair follicle bulge with the cell surface marker CD34. (
  • CD34 was first identified as an antigen expressed on hematopoietic progenitors, and has since been extensively used as a marker to isolate cells capable of hematopoietic cell engraftment. (
  • CD34 is a stem cell marker although its expression on human hematopoietic stem cells is reversible. (
  • [ citation needed ] Human HSCs express the CD34 marker. (
  • Even though the keratocytes lost their CD34 phenotype marker, the absence of smooth muscle actin fibers showed that these cells had not differentiated into myofibroblasts. (
  • Other more important CD antigens include the leukocytes integrins (CD11/CD18) and the hematopoietic stem cell marker CD34. (
  • CMCs are phenotypically and molecularly heterogeneous, thus we performed a "home-made Liquid-Biopsy," by targeting the melanoma-associated-antigen, MCAM/MUC18/CD146, and/or the melanoma-initiating marker, ABCB5. (
  • CD34 is a cluster of differentiation first described independently by Civin et al. (
  • CD34 derives its name from the cluster of differentiation protocol that identifies cell surface antigens. (
  • However, there are some mutations leading to an aberrant activation of proteins that have a crucial effect on hematopoietic progenitor cell proliferation and differentiation. (
  • Our analysis of bone marrow samples from 50 patients with MDS showed aberrant expression of differentiation antigens in the myelomonocytic lineage. (
  • Wilm's Tumor 1 (WT1) was identified as a target vaccine antigen because this antigen is over-expressed by cluster of differentiation 34 (CD34) plus stem cells of most patients with myeloid and lymphoid malignancies but not by normal marrow cells. (
  • 17 ) transduced autologous T cells ex vivo with a vector expressing a natural T-cell receptor (TCR) specific for the melanoma-associated antigen recognized by T-cells 1 [MART-1(26-35)] epitope and reintroduced them into patients, resulting in tumor regression in two of the 15 subjects ( 17 ). (
  • FLT3 mutations result in constitutive activation of the FLT3 receptor kinase in the absence of FLT3 ligand and abnormal activation of downstream signaling pathways, including signal transducer and activator of transcription 5 (STAT5), mitogen-activated protein kinase kinase (Mek)/extracellular signal-regulated kinase (Erk) and phosphatidylinositol-3 kinase (PI3K). (
  • a) Among DC populations, MIP-3α was the most potent chemokine inducing the selective migration of in vitro-generated CD34 + hematopoietic progenitor cell-derived LC precursors and skin LCs in accordance with the restricted MIP-3α receptor (CC chemokine receptor 6) expression to these cells. (
  • Recently, several studies, including ours, have demonstrated that the traffic of DCs from the site of antigen capture to the draining lymphoid organs involves selective chemokines active on maturing DCs through CC chemokine receptor (CCR)7 ( 7 )( 8 )( 9 )( 10 ). (
  • CD antigens appear to carry out cytokine receptor-like functions such as CD27, CD30 and CD40. (
  • For example, disclosed herein are genetically-modified cells comprising a chimeric antigen receptor or an inducible regulatory construct incorporating the co-stimulatory domains disclosed herein. (
  • It is a 38 kD seven-pass transmembrane receptor coupled to G-protein. (
  • Here, we explain how a T-cell receptor (TCR) achieves high specificity toward a peptide antigen presented by allo-major histocompatibility complex (MHC). (
  • It functions as a co-receptor for B-cell antigen receptor (BCR), regulating signal transduction. (
  • CD4 is an accessory protein for MHC class-II antigen/T-cell receptor interaction. (
  • Receptor-type tyrosine-protein phosphatase C (CD45) regulates signal transduction and lymphocyte activation by specific association with receptor molecules on T and B cells. (
  • Members of this family are single pass transmembrane proteins with a heavily glycosylated extracellular and N-terminal mucin domain. (
  • CD antigens have been characterized as both transmembrane proteins and cell surface proteins anchored to the plasma membrane via covalent attachment to fatty acid-containing glycolipids such as glycosylphosphatidylinositol (GPI). (
  • A collection of articles that focus on an array of different scientific topics such as pathways, cancer, transmembrane proteins. (
  • Diseases associated with CD34 dysfunction include dermatofibrosarcoma and neurofibroma. (
  • Diseases associated with CD34 include Spindle Cell Lipoma and Dermatofibrosarcoma Protuberans . (
  • Hematopoietic progenitor cell antigen CD34 also known as CD34 antigen is a protein that in humans is encoded by the CD34 gene. (
  • CD34 is a transmembrane phosphoglycoprotein protein encoded by the CD34 gene in humans, mice, rats and other species. (
  • SPT20 homolog is a protein that in humans is encoded by the SUPT20H gene. (
  • The protein encoded by this gene may play a role in the attachment of stem cells to the bone marrow extracellular matrix or to stromal cells. (
  • This single-pass membrane protein is highly glycosylated and phosphorylated by protein kinase C. Two transcript variants encoding different isoforms have been found for this gene. (
  • A protein that is a translation product of the human CD19 gene or a 1:1 ortholog thereof. (
  • Gene expression of β-defensin 4A (bBD-4A), NK-lysine 1 (NK1), cathelicidin 2 (CATHL2), hepcidin (HEP) and indoleamine 2,3 dioxygenase (IDO) and protein expression of bBD-4A were determined in activated and non-activated cells. (
  • 2, p63, smooth muscle actin, and glial fibrillary acid protein yielded negative results. (
  • In addition, CD34 is expressed by soft tissue tumors, such as solitary fibrous tumor and gastrointestinal stromal tumor. (
  • A negative CD34 may exclude Ewing's sarcoma /PNET, myofibrosarcoma of the breast, and inflammatory myofibroblastic tumors of the stomach. (
  • The CD34 protein is a hematopoietic progenitor cell antigen that occurs in a variety of mesenchymal tumors. (
  • EPCs were identified by flow cytometry for CD34/CD133/VEGFR2/CXCR4 antigens. (
  • The important clinical application of the flow cytometry is the CD34 + quantification to hematopoietic reconstitution after stem cell transplant and lymphocyte subsets to evaluate the immune reply to tissue or organ transplant and animals diseases. (
  • Treatment with cytotoxic T-lymphocyte (CTL) lines or clones that are specifically generated against leukemic antigen-presenting cells from the patient, may separate antileukemic effects from GVHD. (
  • In this report we demonstrate that after culturing CD34-positive cells purified from bone marrow of patients with chronic phase CML in medium containing human serum, GM-CSF, TNF alpha, and IL-4 up to 28% of the cultured cells were dendritic cells, characterized by morphology, phenotypic analysis, and their efficient capacity to stimulate allogeneic T lymphocytes. (
  • In addition to expression on hematopoietic progenitors, CD34 is expressed on some populations of mesenchymal stem cells, tumor cell lines, and by vascular endothelia in the adult. (
  • Further, CD34 could act as a scaffold for the attachment of lineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or other marrow components. (
  • The presence of CD34 on non-hematopoietic cells in various tissues has been linked to progenitor and adult stem cell phenotypes. (
  • CD34 is expressed in roughly 20% of murine hematopoietic stem cells, [21] and can be stimulated and reversed. (
  • CD34 was first described on hematopoietic stem cells independently by Civin et al. (
  • Due to these historical and clinical associations, CD34 expression is almost ubiquitously related to hematopoietic cells however it is actually found on many other cell types as well. (
  • These autologous T cells have been generated either by ex vivo manipulation of antigen-specific T cells with cytokines or by genetically engineering T cells to exhibit strong antitumor responses ( 5 - 16 ). (
  • Recent clinical studies have used chimeric antigen receptors to modify T cells genetically to target and deplete leukemia cells ( 5 , 6 ). (
  • Some of these limitations could be circumvented by the use of genetically modified human hematopoietic stem cells (hHSC) to generate mature and functional antigen-specific T cells. (
  • Antigen-specific human T cells have been developed in vitro using OP9 stromal cells expressing the human Notch ligand Delta-like 1 ( 25 , 26 ). (
  • 7 - 11 Mcl-1 is an antiapoptotic Bcl-2 family protein, which plays critical roles in promoting survival of normal and malignant hematopoietic cells. (
  • Abgent has over fifteen years of experience producing recombinant proteins in E. coli and mammalian cells (CHO and HEK293, etc), and we have added a powerful yeast expression platform to our menu of services. (
  • Neoplastic cells showed immunoreactivity for CD34 (12 patients). (
  • Langerhans cells (LCs) represent a unique population of DCs colonizing epithelium, and we present here observations suggesting that macrophage inflammatory protein (MIP)-3α plays a central role in LC precursor recruitment into the epithelium during inflammation. (
  • In the periphery, immature DCs such as Langerhans cells (LCs) capture antigens ( 6 ) and, under the influence of inflammatory stimuli, subsequently migrate via the lymphatic system or blood vessels. (
  • They reach secondary lymphoid organs and home to the T cell-rich areas, where they present processed antigen to naive T cells and generate antigen-specific primary T cell responses. (
  • In order to broad- en the array of tools for cell-based autologous therapies, we iso- lated a novel renewable stem cell population from the adult testes that has characteristics of MSCs, termed gonadal stem cells (GSCs). (
  • As lymphocytes mature, they express different protein receptors on the cell surface, which can aid in determining the type and maturation stage of the cells being examined. (
  • During the course of development from precursor cells into functionally mature forms, lymphocytes display a complex pattern of surface antigens, some of which are acquired at certain stages while others are lost. (
  • Dao MA, Arevalo J, Nolta JA: Reversibility of CD34 expression on human hematopoietic stem cells that retain the capacity for secondary reconstitution. (
  • Gangenahalli GU, Singh VK, Verma YK, Gupta P, Sharma RK, Chandra R, Gulati S, Luthra PM: Three-dimensional structure prediction of the interaction of CD34 with the SH3 domain of Crk-L. Stem Cells Dev. (
  • The vaccine contains part of a protein that is produced in large amounts by cells of patients with these cancers and an added substance called Montanide that helps the immune system respond to the vaccine. (
  • A human leukocyte antigen (HLA-A0201) restricted peptide derived from the Wilm's Tumor (WT) protein is anticipated to induce T cell response against MDS and leukemic cells while sparing normal cells. (
  • Human dendritic cells (DC) can now be generated in vitro in large numbers by culturing CD34 + hematopoietic progenitors in presence of GM-CSF+TNFet for 12 d. (
  • In contrast, the CD14 + progenitors mature into CDla + DC lacking Birbeck granules, E-cadherin, and Lag antigen but expressing CD2, CD9, CD68, and the coagulation factor XIlla described in dermal dendritic cells. (
  • The present disclosure provides novel co-stimulatory domains useful in genetically-modified cells to promote cell proliferation and/or promote cytokine secretion after antigen recognition. (
  • To assess the functional implications of HLA class I APM component down-regulation in Mb cell lines, we tested their recognition by HLA class I antigen-restricted, tumor antigen (TA)-specific CTL, generated by stimulations with dendritic cells that had been transfected with Mb mRNA. (
  • Recognition of tumor cells by human leukocyte antigen (HLA) class I antigen-restricted, tumor antigen (TA)-specific CTLs is mediated by β2-microglobulin-associated HLA class I heavy chains (HC) loaded with TA-derived peptides. (
  • Both cuboidal and polygonal cells were negative to CD34 and mesothelial antigen staining. (
  • The interaction of CD47 with signal regulatory protein alpha (SIRPα), a protein on phagocytic cells, transmits a "don't eat me" signal that negatively regulates phagocytosis. (
  • A potential limitation of therapeutic CD47-SIRPα antagonists is that expression of CD47 on normal cells may create sites of toxicity or an "antigen sink. (
  • SIRPabodies selectively bound to dual antigen-expressing tumor cells in the presence of a large antigen sink. (
  • Tissue, cells or virus corresponding to Mouse CD34. (
  • In the 1 case of GIST, the cell type is spindle and GIST cells were immunohistochemically positive for KIT and CD34. (
  • However, the complicated culturing conditions for in vitro expansion of MSCs, together with the required HLA (human histocompatibility leukocyte antigen) matching for hUCB transplantation between donor and recipient, may limit the clinical application of these cells. (
  • Independent of location, most GISTs express the CD34 antigen (70-78%) and the CD117 (72-94%) antigen. (
  • On immunohistochemistry examination, the tumor was found to have CD117 antigen, which is an established hallmark of GIST. (
  • CD34 is a highly glycosylated monomeric with a molecular weight range of 111-115 kDa surface protein that is present on many stem cell populations. (
  • CD34 is a highly glycosylated, monomeric, 111-115 kDa surface protein that is present on many stem cell populations. (
  • CD34 is a highly glycosylated monomeric 111-115kDa surface protein, which is present on many stem cell populations. (
  • In Western blot, the reported molecular mass of CD34 is ranging from 100 to 120 kDa, apart from the HEV form (Sgp90) which is about 90 kDa. (
  • With state-of-the art molecular biology and protein biochemistry labs, we work with our clients to rapidly evaluate in parallel to identify the optimal expression system for candidate proteins. (
  • Clinical and Molecular Evidence of ABCC11 Protein Expression in Axillary Apocrine Glands of Patients with Axillary Osmidrosis. (
  • It is composed of an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic protein-tyrosine phosphatase domains. (
  • CD34 expression is likely to represent a specific state of hematopoietic development that may have altered adhering properties with expanding and differentiating capabilities in both in vitro and in vivo conditions. (
  • The CD34 protein is a member of a family of single-pass transmembrane sialomucin proteins that show expression on early hematopoietic and vascular-associated tissue. (
  • Density of the microvessels was being evaluated basing on the expression of the antigen CD34 and CD105. (
  • Apoptosis and proliferation in thyroid carcinoma: correlation with bcl-2 and p53 protein expression. (
  • Prognostic significance of CD34 expression in early cervical squamous cell carcinoma. (
  • The expression of CD antigens is influenced by cytokines, such as binding of ligands to CD antigens which has shown to modulate the expression of cytokines. (
  • SDF-1 protein expression was reduced in experimental and human cavernosal diabetic samples, an effect prevented by insulin in treated animals. (
  • Insulin administration rescued the effects of diabetes on BM function, CECs levels, testosterone, and plasmatic/penile SDF-1 protein expression. (
  • Expression of glial fibrillary acidic protein was weak, and the presence o f Ki-67 protein demonstrated a low proliferation rate (figure 2,C). (
  • Defects in the expression and/or function of the human leukocyte antigen (HLA) class I antigen-processing machinery (APM) components are found in many tumor types. (
  • We also compared expression of Smad4 protein between OSCC lines and normal oral keratinocytes, using Western blot analysis. (
  • However, little data are available for the expression of ABCC11 protein in human axillary apocrine glands that produce apocrine sweat-a source of odor from the armpits. (
  • Furthermore, we examined the expression of ABCC11 protein in human axillary apocrine glands extracted from axillary osmidrosis patients carrying each genotype: 538GG, GA, and AA. (
  • To determine the role of COX-2 expression in gastric cancers, we examined the PG levels and microvessel density in patients with gastric cancer, and then compared the findings with the expression of COX-2 protein. (
  • It provides information about protein size and reveals differences in protein expression between particular leukemia subgroups. (
  • The third subpopulation isolated based on concurrent MCAM and ABCB5 protein expression showed an invasive phenotype. (
  • The bar plot below shows the proportion of tumor samples that have any kind of altering mutation(s) in the given protein. (
  • Gastric gastrointestinal stromal tumor (GIST) en face. (
  • A left nasolacrimal duct tumor was excised en bloc by lateral rhinotomy. (
  • They traffic from the blood to the tissues where, while immature, they capture antigens. (
  • The majority of BM-MSC and AT-MSC expressed CD73, Oct4 and Nanog, and were negative for CD34. (
  • CD antigens participate in immune reaction as receptors for cell communication (e.g. adherence molecules, antigen recognizing receptors). (
  • CD antigens have been shown to be identical with receptors of cytokines such as CD25 (TAC antigen). (
  • Cell surface antigens of leukocytes are called CD antigens, and important for immune reactions of organisms. (
  • Clone REA897 recognizes the human CD90 antigen, which is a 25-35 kD GPI-anchored protein of the Ig superfamily. (
  • For immunohistochemistry, CD34 was from Abcam, rabbit anti-goat from Dako, and IFNγR from Santa Cruz. (
  • Further studies have shown that TRA-1-81 is a neuroaminidase-resistant carbohydrate epitope expressed on podocalyxin, a member of mucin-like glycoprotein with CD34 family. (
  • HCV1406 was subsequently shown to recognize the HCV nonstructural protein 3 (NS3):1406-1415 epitope with high specificity when presented by HLA-A2. (
  • CD34 staining of human tonsil tissue. (
  • 6Ckine (secondary lymphoid tissue chemokine [SLC], Exodus-2) expressed by lymphatic vessels may direct into the lymph stream antigen-loaded maturing DCs leaving the site of infection ( 11 )( 12 )( 13 )( 14 ). (
  • Nasal-associated lymphoid tissue (NALT) is a mucosal immune tissue that provides immune responses against inhaled antigens. (
  • The intracellular chain of the CD34 antigen is a site of phosphorylation by activated protein kinase C suggesting a putative role in signal transduction. (
  • In recent studies, we have shown that type I IFNs (IFN-α and IFN-β) activate the p38 mitogen-activated protein (Map) kinase signaling cascade ( 13 , 14 , 15 , 16 ). (
  • 10) PLGAmay stain with glial fibrillary acidic protein (GFAP), but this is usually less consistent than is GFAP staining of pleomorphic adenomas. (
  • Chemically, these fibers are composed of glial fibrillary acidic protein and alpha-beta crystallin. (
  • [16] [17] Finally, recent data suggest CD34 may also play a more selective role in chemokine-dependent migration of eosinophils and dendritic cell precursors. (
  • Finally, recent data suggest CD34 may also play a more selective role in chemokine-dependent migration of eosinophils and dendritic cell precursors. (