Amyloid: A fibrous protein complex that consists of proteins folded into a specific cross beta-pleated sheet structure. This fibrillar structure has been found as an alternative folding pattern for a variety of functional proteins. Deposits of amyloid in the form of AMYLOID PLAQUES are associated with a variety of degenerative diseases. The amyloid structure has also been found in a number of functional proteins that are unrelated to disease.Prions: Small proteinaceous infectious particles which resist inactivation by procedures that modify NUCLEIC ACIDS and contain an abnormal isoform of a cellular protein which is a major and necessary component. The abnormal (scrapie) isoform is PrPSc (PRPSC PROTEINS) and the cellular isoform PrPC (PRPC PROTEINS). The primary amino acid sequence of the two isoforms is identical. Human diseases caused by prions include CREUTZFELDT-JAKOB SYNDROME; GERSTMANN-STRAUSSLER SYNDROME; and INSOMNIA, FATAL FAMILIAL.Prion Diseases: A group of genetic, infectious, or sporadic degenerative human and animal nervous system disorders associated with abnormal PRIONS. These diseases are characterized by conversion of the normal prion protein to an abnormal configuration via a post-translational process. In humans, these conditions generally feature DEMENTIA; ATAXIA; and a fatal outcome. Pathologic features include a spongiform encephalopathy without evidence of inflammation. The older literature occasionally refers to these as unconventional SLOW VIRUS DISEASES. (From Proc Natl Acad Sci USA 1998 Nov 10;95(23):13363-83)Amyloid beta-Peptides: Peptides generated from AMYLOID BETA-PEPTIDES PRECURSOR. An amyloid fibrillar form of these peptides is the major component of amyloid plaques found in individuals with Alzheimer's disease and in aged individuals with trisomy 21 (DOWN SYNDROME). The peptide is found predominantly in the nervous system, but there have been reports of its presence in non-neural tissue.Serum Amyloid A Protein: An ACUTE PHASE REACTION protein present in low concentrations in normal sera, but found at higher concentrations in sera of older persons and in patients with AMYLOIDOSIS. It is the circulating precusor of amyloid A protein, which is found deposited in AA type AMYLOID FIBRILS.Amyloid beta-Protein Precursor: A single-pass type I membrane protein. It is cleaved by AMYLOID PRECURSOR PROTEIN SECRETASES to produce peptides of varying amino acid lengths. A 39-42 amino acid peptide, AMYLOID BETA-PEPTIDES is a principal component of the extracellular amyloid in SENILE PLAQUES.Plaque, Amyloid: Accumulations of extracellularly deposited AMYLOID FIBRILS within tissues.Islet Amyloid Polypeptide: A pancreatic beta-cell hormone that is co-secreted with INSULIN. It displays an anorectic effect on nutrient metabolism by inhibiting gastric acid secretion, gastric emptying and postprandial GLUCAGON secretion. Islet amyloid polypeptide can fold into AMYLOID FIBRILS that have been found as a major constituent of pancreatic AMYLOID DEPOSITS.Amyloidosis: A group of sporadic, familial and/or inherited, degenerative, and infectious disease processes, linked by the common theme of abnormal protein folding and deposition of AMYLOID. As the amyloid deposits enlarge they displace normal tissue structures, causing disruption of function. Various signs and symptoms depend on the location and size of the deposits.Cerebral Amyloid Angiopathy: A heterogeneous group of sporadic or familial disorders characterized by AMYLOID deposits in the walls of small and medium sized blood vessels of CEREBRAL CORTEX and MENINGES. Clinical features include multiple, small lobar CEREBRAL HEMORRHAGE; cerebral ischemia (BRAIN ISCHEMIA); and CEREBRAL INFARCTION. Cerebral amyloid angiopathy is unrelated to generalized AMYLOIDOSIS. Amyloidogenic peptides in this condition are nearly always the same ones found in ALZHEIMER DISEASE. (from Kumar: Robbins and Cotran: Pathologic Basis of Disease, 7th ed., 2005)Serum Amyloid P-Component: Amyloid P component is a small, non-fibrillar glycoprotein found in normal serum and in all amyloid deposits. It has a pentagonal (pentaxin) structure. It is an acute phase protein, modulates immunologic responses, inhibits ELASTASE, and has been suggested as an indicator of LIVER DISEASE.Amyloid Neuropathies: Disorders of the peripheral nervous system associated with the deposition of AMYLOID in nerve tissue. Familial, primary (nonfamilial), and secondary forms have been described. Some familial subtypes demonstrate an autosomal dominant pattern of inheritance. Clinical manifestations include sensory loss, mild weakness, autonomic dysfunction, and CARPAL TUNNEL SYNDROME. (Adams et al., Principles of Neurology, 6th ed, p1349)Amyloid Precursor Protein Secretases: Endopeptidases that are specific for AMYLOID PROTEIN PRECURSOR. Three secretase subtypes referred to as alpha, beta, and gamma have been identified based upon the region of amyloid protein precursor they cleave.Alzheimer Disease: A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57)Congo Red: An acid dye used in testing for hydrochloric acid in gastric contents. It is also used histologically to test for AMYLOIDOSIS.Amyloid Neuropathies, Familial: Inherited disorders of the peripheral nervous system associated with the deposition of AMYLOID in nerve tissue. The different clinical types based on symptoms correspond to the presence of a variety of mutations in several different proteins including transthyretin (PREALBUMIN); APOLIPOPROTEIN A-I; and GELSOLIN.Prealbumin: A tetrameric protein, molecular weight between 50,000 and 70,000, consisting of 4 equal chains, and migrating on electrophoresis in 3 fractions more mobile than serum albumin. Its concentration ranges from 7 to 33 per cent in the serum, but levels decrease in liver disease.Peptide Fragments: Partial proteins formed by partial hydrolysis of complete proteins or generated through PROTEIN ENGINEERING techniques.Aspartic Acid Endopeptidases: A sub-subclass of endopeptidases that depend on an ASPARTIC ACID residue for their activity.Presenilin-1: Integral membrane protein of Golgi and endoplasmic reticulum. Its homodimer is an essential component of the gamma-secretase complex that catalyzes the cleavage of membrane proteins such as NOTCH RECEPTORS and AMYLOID BETA-PEPTIDES precursors. PSEN1 mutations cause early-onset ALZHEIMER DISEASE type 3 that may occur as early as 30 years of age in humans.ThiazolesMice, Transgenic: Laboratory mice that have been produced from a genetically manipulated EGG or EMBRYO, MAMMALIAN.Brain: The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM.Cerebral Amyloid Angiopathy, Familial: A familial disorder marked by AMYLOID deposits in the walls of small and medium sized blood vessels of CEREBRAL CORTEX and MENINGES.Protein Structure, Secondary: The level of protein structure in which regular hydrogen-bond interactions within contiguous stretches of polypeptide chain give rise to alpha helices, beta strands (which align to form beta sheets) or other types of coils. This is the first folding level of protein conformation.Amyloidosis, Familial: Diseases in which there is a familial pattern of AMYLOIDOSIS.Neurofibrillary Tangles: Abnormal structures located in various parts of the brain and composed of dense arrays of paired helical filaments (neurofilaments and microtubules). These double helical stacks of transverse subunits are twisted into left-handed ribbon-like filaments that likely incorporate the following proteins: (1) the intermediate filaments: medium- and high-molecular-weight neurofilaments; (2) the microtubule-associated proteins map-2 and tau; (3) actin; and (4) UBIQUITINS. As one of the hallmarks of ALZHEIMER DISEASE, the neurofibrillary tangles eventually occupy the whole of the cytoplasm in certain classes of cell in the neocortex, hippocampus, brain stem, and diencephalon. The number of these tangles, as seen in post mortem histology, correlates with the degree of dementia during life. Some studies suggest that tangle antigens leak into the systemic circulation both in the course of normal aging and in cases of Alzheimer disease.Encyclopedias as Topic: Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)Centralized Hospital Services: The coordination of services in one area of a facility to improve efficiency.Computational Biology: A field of biology concerned with the development of techniques for the collection and manipulation of biological data, and the use of such data to make biological discoveries or predictions. This field encompasses all computational methods and theories for solving biological problems including manipulation of models and datasets.PubMed: A bibliographic database that includes MEDLINE as its primary subset. It is produced by the National Center for Biotechnology Information (NCBI), part of the NATIONAL LIBRARY OF MEDICINE. PubMed, which is searchable through NLM's Web site, also includes access to additional citations to selected life sciences journals not in MEDLINE, and links to other resources such as the full-text of articles at participating publishers' Web sites, NCBI's molecular biology databases, and PubMed Central.Periodicals as Topic: A publication issued at stated, more or less regular, intervals.BooksIpecac: A syrup made from the dried rhizomes of two different species, CEPHAELIS ipecacuanha and C. acuminata. They contain EMETINE, cephaeline, psychotrine and other ISOQUINOLINES. Ipecac syrup is used widely as an emetic acting both locally on the gastric mucosa and centrally on the chemoreceptor trigger zone.Microdissection: The performance of dissections with the aid of a microscope.Faculty, Medical: The teaching staff and members of the administrative staff having academic rank in a medical school.Laser Capture Microdissection: Techniques using a laser to cut away and harvest a specific cell or cluster of cells from a tissue section while viewing it under the microscope.Paragonimus: A genus of lung flukes of the family Troglotrematidae infecting humans and animals. This genus consists of several species one of which is PARAGONIMUS WESTERMANI, a common lung fluke in humans.Molybdoferredoxin: A non-heme iron-sulfur protein isolated from Clostridium pasteurianum and other bacteria. It is a component of NITROGENASE, which is active in nitrogen fixation, and consists of two subunits with molecular weights of 59.5 kDa and 50.7 kDa, respectively.Nitrogenase: An enzyme system that catalyzes the fixing of nitrogen in soil bacteria and blue-green algae (CYANOBACTERIA). EC 1.18.6.1.Receptors, Calcitonin Gene-Related Peptide: Cell surface proteins that bind CALCITONIN GENE-RELATED PEPTIDE with high affinity and trigger intracellular changes which influence the behavior of cells. CGRP receptors are present in both the CENTRAL NERVOUS SYSTEM and the periphery. They are formed via the heterodimerization of the CALCITONIN RECEPTOR-LIKE PROTEIN and RECEPTOR ACTIVITY-MODIFYING PROTEIN 1.Azotobacter vinelandii: A species of gram-negative, aerobic bacteria first isolated from soil in Vineland, New Jersey. Ammonium and nitrate are used as nitrogen sources by this bacterium. It is distinguished from other members of its genus by the ability to use rhamnose as a carbon source. (From Bergey's Manual of Determinative Bacteriology, 9th ed)Antibodies: Immunoglobulin molecules having a specific amino acid sequence by virtue of which they interact only with the ANTIGEN (or a very similar shape) that induced their synthesis in cells of the lymphoid series (especially PLASMA CELLS).CitrullineResearch Support, U.S. Gov't, Non-P.H.S.Research Support, U.S. Gov't, P.H.S.Research Support, Non-U.S. Gov'tResearch Support, U.S. GovernmentResearch Support, American Recovery and Reinvestment ActResearch Support, N.I.H., ExtramuralResearch Support, N.I.H., Intramural
... actually is rich in protein. Subsequent research has shown that many different proteins can form amyloid, and that all amyloids ... Lundmark K, Westermark GT, Olsen A, Westermark P (2005). "Protein fibrils in nature can enhance amyloid protein A amyloidosis ... proteins that assist protein folding) may antagonize proteotoxicity during aging and in protein misfolding-diseases to maintain ... Eisenberg, D; Jucker, M (2012). "The amyloid state of proteins in human diseases". Cell. 148: 1188-1203. doi:10.1016/j.cell. ...
... skeletal muscle-specific Ca2+/calmodulin-dependent protein kinase; Akt; Beta-amyloid precursor protein (betaAPP); Huntingtin. ... For example, GAPDH interactions with beta-amyloid precursor protein (betaAPP) could interfere with its function regarding the ... GAPDH participates in a number of biological functions through its protein-protein interactions with: tubulin to facilitate ... where it ubiquitinates and degrades nuclear proteins during nitrosative stress conditions; GAPDH's competitor of Siah protein ...
Chen Y, Bodles AM (2007). "Amyloid precursor protein modulates beta-catenin degradation". Journal of Neuroinflammation. 4: 29. ... Beta-catenin-interacting protein 1 is a protein that is encoded in humans by the CTNNBIP1 gene. The protein encoded by this ... 2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi: ... CTNNBIP1 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH) Human CTNNBIP1 genome location ...
ISBN 978-90-5702-173-2. Wischik CM, Wischik DJ, Storey JM, Harrington CR (2010). "Beta-Amyloid, Tau Protein and Glucose ... The company's protein aggregation inhibitors target the underlying pathology of dementia, with the aim of modifying or halting ... Their lead compound, LMTX, targets aggregation of tau and is believed to act on synuclein, TDP-43 and huntingtin protein. Its ... Brain Microtubule Associated Proteins: Modifications in Disease. Amsterdam: Harwood Acad. Publ. pp. 185-241. ...
... or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of ... "A myristoylated calcium-binding protein that preferentially interacts with the Alzheimer's disease presenilin 2 protein". J. ... Presenilin-2 is a protein that in humans is encoded by the PSEN2 gene. Alzheimer's disease (AD) patients with an inherited form ... APH-1 interacts with presenilin and nicastrin and is required for intramembrane proteolysis of amyloid-beta precursor protein ...
... amyloid state of proteins. Amyloid-related diseases include whole-body disorders such as the systemic amyloidoses, neuronal ... Knowles, T. P. J.; Vendruscolo, M.; Dobson, C. M. (2014). "The amyloid state and its association with protein misfolding ... Chiti, F.; Dobson, C. M. (2009). "Amyloid formation by globular proteins under native conditions". Nature Chemical Biology. 5 ( ... Chiti, F.; Dobson, C. (2006). "Protein misfolding, functional amyloid, and human disease". Annual Review of Biochemistry. 75: ...
Protein function is dependent on the oligomeric form; therefore, the protein's function can be regulated by shifting the ... this distinguishes morpheeins from prions and amyloid. The different oligomers have distinct functionality. Interconversion of ... Kumagai, H; Sakai, H (1983). "A porcine brain protein (35 K protein) which bundles microtubules and its identification as ... Morpheeins are proteins that can form two or more different homo-oligomers (morpheein forms), but must come apart and change ...
These amyloid fibrils are seen as the result of pathogenic proteins that self-propagate and form highly stable, non-functional ... One idea, the "Protein X" hypothesis, is that an as-yet unidentified cellular protein (Protein X) enables the conversion of ... the specific protein that the prion was composed of is also known as the Prion Protein (PrP), though this protein may occur ... While asserting that the flow of sequence information from protein to protein, or from protein to RNA and DNA was "precluded", ...
Fink, AL (1998). "Protein aggregation: folding aggregates, inclusion bodies and amyloid". Folding & Design. 3 (1): R9-23. doi: ... Monsellier, E; Chiti, F (Aug 2007). "Prevention of amyloid-like aggregation as a driving force of protein evolution". EMBO ... Protein mutation tolerance is the product of two main features: the structure of the genetic code and protein structural ... Proteins are resistant to mutations because many sequences can fold into highly similar structural folds. A protein adopts a ...
Fink, AL (1998). "Protein aggregation: folding aggregates, inclusion bodies and amyloid". Folding & Design. 3 (1): R9-23. doi: ... Monsellier, E; Chiti, F (Aug 2007). "Prevention of amyloid-like aggregation as a driving force of protein evolution". EMBO ... Proteins are resistant to mutations because many sequences can fold into highly similar structural folds. A protein adopts a ... Proteins have also evolved to avoid aggregation as partially folded proteins can combine to form large, repeating, insoluble ...
The other is the Amyloid-beta precursor protein. This protein is an integral membrane protein found most commonly in the ... September 2011). "Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, ... Analysis of protein composition also suggests that the protein has relatively low levels of glycine. This could suggest a ... The subcellular localization for the protein is predicted to be the nucleus and the cytoplasm. This suggests that the protein ...
Amyloid beta A4 precursor protein-binding family B member 1-interacting protein (APBB1IP), also known as APBB1-interacting ... amyloid beta (A4) precursor protein-binding". Inagaki T, Suzuki S, Miyamoto T, Takeda T, Yamashita K, Komatsu A, Yamauchi K, ... 1997). "The WW domain of neural protein FE65 interacts with proline-rich motifs in Mena, the mammalian homolog of Drosophila ... protein 1 or Rap1-GTP-interacting adapter molecule (RIAM) is a protein that in humans is encoded by the APBB1IP gene. GRCh38: ...
Beta-amyloid is a fragment from a larger protein called amyloid precursor protein (APP), a transmembrane protein that ... "Roles of proteolysis and lipid rafts in the processing of the amyloid precursor protein and prion protein". Biochem. Soc. Trans ... tau: hyperphosphorylated tau protein is the main component of neurofibrillary tangles in Alzheimer's disease. beta amyloid: the ... Turner PR, O'Connor K, Tate WP, Abraham WC (May 2003). "Roles of amyloid precursor protein and its fragments in regulating ...
APP is an Amyloid beta A4 precursor protein. It is suspected to have a major role in cognitive difficulties. Another gene, ETS2 ... Online Mendelian Inheritance in Man (OMIM) AMYLOID BETA A4 PRECURSOR PROTEIN; APP -104760, gene located at 21q21. Retrieved on ... Neurofibrillary tangles and amyloid plaques are commonly found in both Down syndrome and Alzheimer's individuals. Layer II of ... show that 41% of the genes on chromosome-21 have no functional purpose, and only 54% of functional genes have a known protein ...
The most well-known substrate of gamma secretase is amyloid precursor protein, a large integral membrane protein that, when ... complex with the γ-secretase activating protein facilitates the gamma cleavage of amyloid precursor protein into β-amyloid. The ... Zhang, H; Ma, Q; Zhang, YW; Xu, H (January 2012). "Proteolytic processing of Alzheimer's β-amyloid precursor protein". Journal ... including amyloid precursor protein (APP) and Notch. Substrate recognition occurs via nicastrin ectodomain binding to the N- ...
He is known for his researches in the fields of computational genomics and protein structure analysis. An elected fellow of the ... "Structure of pentameric human serum amyloid P component". Nature. 367 (6461): 338-345. doi:10.1038/367338a0. PMID 8114934. CS1 ... "Multi-Protein Complexes Involved in Cell Regulation (E6)". Keystone Symposia. 2006. Retrieved October 24, 2016. "Scientific ... In 2010, he was promoted as a professor and he heads the Proteins : Structure, Function and Evolutionary Group, popularly known ...
Plaques are clumps of a protein called beta-amyloid. They may damage and destroy brain cells by interfering with cell-to-cell ... The collection of beta-amyloid on the outside of brain cells is thought to be implicated in the cause of this disease. Tangles ... are threads of another protein, tau. Tau twist into abnormal tangles inside brain cells, resulting in failure of the transport ...
Gamma secretase is a protein complex thought to be a fundamental building block in the development of the amyloid beta peptide ... Palmqvist, Sebastian (Oct 2014). "Accuracy of brain amyloid detection in clinical practice using cerebrospinal fluid β-amyloid ... amyloid protein precursor (APP) was found to be indirectly related based on network analysis. Aβ (one of the diagnostic ... vaccines against amyloid beta. Other approaches are neuroprotective agents, like AL-108 (phase II completed); or metal-protein ...
His research interests pertain to prions and amyloid diseases. [URE3] as an altered URE2 protein: evidence for a prion analog ... were caused by prion forms of native proteins - specifically, the Sup35p and Ure2p proteins, respectively. Reed Wickner ...
Nicoll, J.A.; Roberts, G. W.; Graham, D. I. (1996). "Amyloid beta-protein, APOE genotype and head injury (review)". Annals of ...
"Tetraspanin12 regulates ADAM10-dependent cleavage of amyloid precursor protein". FASEB J. 23 (11): 3674-81. doi:10.1096/fj.09- ... It also binds to the MT1-MMP metalloprotease protein that is closely related to ADAM10 but has a minimal effect on promotion of ... Its main binding partner is the ADAM10 protein, a sheddase that interacts with a variety of adhesion molecules that are found ... Lafleur MA, Xu D, Hemler ME (April 2009). "Tetraspanin proteins regulate membrane type-1 matrix metalloproteinase-dependent ...
Amyloid plaques formed by amyloid-β (Aβ) deposition and neurofibrillary tangles formed by tau protein phosphorylation are ... Amyloid precursor protein (APP) proteolysis is fundamental for production of Aβ peptides implicated in AD pathology. By using a ... JAFFE, AB; et.al (1994). "ESTROGEN REGULATES METABOLISM OF ALZHEIMER AMYLOID-BETA PRECURSOR PROTEIN". Journal of Biological ... The role of estrogens is mostly mediated by two nuclear receptors (ER alpha and ER beta) and a membrane-associated G-protein ( ...
... two clotting proteins that lose their function after binding with amyloid. Amyloid deposits in tissue and causes enlargement of ... The type of the amyloid protein can be determined in various ways: the detection of abnormal proteins in the bloodstream (on ... Amyloid fibril proteins and clinical classification of the amyloidosis". Amyloid. 21 (4): 221-224. doi:10.3109/13506129.2014. ... protein fragments are produced, and the fragments come and join together to form the whole protein. But such a protein can ...
Spores are white, elliptical and amyloid. They measure 11-14 x 6-9 µ, and feel smooth. Flesh is white, and shows no change when ... In a study, the presence of non-protein amino acids 2-amino-3-cyclopropylbutanoic acid and 2-amino-5-chloro-4-pentenoic acid ... There is no distinctive odour, but some specimens may develop the smell of decaying protein. Amanita solitaria is a closely ...
When these proteins are active, they turn on SREBP2 which inhibits LRP-1. LRP-1 helps the brain remove amyloid beta. Therefore ... Two proteins are involved in this accumulation of amyloid beta: serum response factor or SRF and myocardin. Together, these 2 ... In this disease, there is a build of the amyloid beta protein in the brain. This ultimately leads to a reduction in the ... when SRF and myocardin are active, there is a buildup in amyloid beta protein which ultimately leads to less blood flow in the ...
Armstrong R, Cairns N, Myers D, Smith C, Lantos P, Rossor M. A comparison of beta-amyloid deposition in the medial temporal ... non-protein-coding genes, and chromosomal structural elements) under selection for biological function.. " Mouse Genome ... This proportion is much higher than can be explained by protein-coding sequences alone, implying that the genome contains many ...
Novel neuritic clusters with accumulations of amyloid precursor protein and amyloid precursor-like protein 2 immunoreactivity ... Novel neuritic clusters with accumulations of amyloid precursor protein and amyloid precursor-like protein 2 immunoreactivity ... Novel neuritic clusters with accumulations of amyloid precursor protein and amyloid precursor-like protein 2 immunoreactivity ... title = "Novel neuritic clusters with accumulations of amyloid precursor protein and amyloid precursor-like protein 2 ...
"Purification and aggregation of the amyloid precursor protein intracellular domain",. abstract = "Amyloid precursor protein ( ... Amyloid precursor protein (APP) is a type I transmembrane protein associated with the pathogenesis of Alzheimers disease (AD ... N2 - Amyloid precursor protein (APP) is a type I transmembrane protein associated with the pathogenesis of Alzheimers disease ... AB - Amyloid precursor protein (APP) is a type I transmembrane protein associated with the pathogenesis of Alzheimers disease ...
Computational Modelling of the Human Islet Amyloid Polypeptide - Author: Skeby, Katrine Kirkeby - Price: 138,35€ ... Study of the Peptide-Peptide and Peptide-Protein Interactions and Their Applications in Cell Imaging and Nanoparticle Surface ... 1. Amyloid and Amyloid Fibrils. Katrine Kirkeby Skeby. 2. Computational Theory. Katrine Kirkeby Skeby. 3. Imaging Agent Binding ... Computational Modelling of the Human Islet Amyloid Polypeptide. 138,35€. Add to cart. Ebook, PDF with Adobe DRM. ISBN: ...
P-glycoprotein efflux and other factors limit brain amyloid beta reduction by beta-site amyloid precursor protein-cleaving ... P-glycoprotein efflux and other factors limit brain amyloid beta reduction by beta-site amyloid precursor protein-cleaving ... P-glycoprotein efflux and other factors limit brain amyloid beta reduction by beta-site amyloid precursor protein-cleaving ... Based on this hypothesis, beta-site amyloid precursor protein (APP)-cleaving enzyme 1 (BACE1) inhibitors are an attractive ...
See how people just like you are living with hereditary cerebral amyloid angiopathy Dutch type. Learn from their data and ... Amyloid proteins build up in the arteries of the brain, which leads to an increased risk of dementia and stroke. ... What is hereditary cerebral amyloid angiopathy Dutch type?. Hereditary cerebral amyloid angiopathy is characterized as a ... Hereditary cerebral amyloid angiopathy Dutch type Were all in this for good.. ...
Abstract Serum amyloid P component (SAP) belongs to the pentraxin family of proteins. SAP is evolutionary conserved, and ... Determination of serum amyloid P component in seminal plasma and correlations with serum hormone levels in young, healthy men. ...
In conclusion, transthyretin hereditary amyloid polyneuropathy (ATTR-PN) should be considered in cases of otherwise idiopathic ... TTR is a homotetrameric plasma protein transporting thyroxine and retinol binding protein-vitamin A complex [1]. It is mainly ... Among the main clinical phenotypes arising from those mutations, hereditary amyloid polyneuropathy (ATTR-PN) and amyloid ... Heterogeneity of penetrance in familial amyloid polyneuropathy, ATTR Val30Met, in the Swedish population. Amyloid, 15(3), 181- ...
Amyloid precursor protein (APP) is an integral membrane protein expressed in many tissues and concentrated in the synapses of ... Chauhan VP, Ray I, Chauhan A, Wisniewski HM (May 1999). "Binding of gelsolin, a secretory protein, to amyloid beta-protein". ... Mutations in critical regions of amyloid precursor protein, including the region that generates amyloid beta (Aβ), cause ... Zheng H, Koo EH (2006). "The amyloid precursor protein: beyond amyloid". Molecular Neurodegeneration. 1 (1): 5. doi:10.1186/ ...
Among other roles in the cell, secretases act on the amyloid precursor protein (APP) to cleave the protein into three fragments ... If α-secretase acts on APP first instead of BACE, no amyloid-β is formed because α-secretase recognizes a target protein ... BACE is a transmembrane protein with an extracellular aspartic acid protease domain. γ-secretase is actually a protein complex ... Sequential cleavage by β-secretase (BACE) and γ-secretase produces the amyloid-β peptide fragment that aggregates into clumps ...
Cutting-edge and authoritative, Amyloid Proteins: Methods and Protocols, Third Edition is a valuable resource for both students ... Purification and Fibrillation of Recombinant Human Amyloid-β, Prion Protein, and Tau Under Native Conditions ... Development of Mouse Monoclonal Antibodies Against Human Amyloid Fibril Proteins for Diagnostic and Research Purposes ... Luminescent-Conjugated Oligothiophene Probe Applications for Fluorescence Imaging of Pure Amyloid Fibrils and Protein ...
... and in which there is the best evidence for the structural sophisitication of the protein aggregates.The critically acclaimed ... This volume includes a core of methodologies to attack the unique experimental problems presented by protein misassembly. ... Amyloid, Prions, and Other Protein Aggregates. Volume 309, Part 1 of Amyloid, Prions, and Other Protein Aggregates: Part [A]-C ... This volume includes a core of methodologies to attack the unique experimental problems presented by protein misassembly. ...
Treatment with a new compound that precisely targets and blocks only amyloid precursor protein reduced plaque accumulation by ... Just one night of bad sleep increases Alzheimers protein A study reveals that levels of a protein called beta-amyloid - which ... The researchers explain that other experimental drugs that tackle amyloid proteins target the enzymes that cleave beta-amyloid ... Alzheimers: Protein from outside the brain may be involved A new study in mice finds that amyloid beta from outside the brain ...
Temperature dependence of amyloid β-protein fibrillization. Yoko Kusumoto, Aleksey Lomakin, David B. Teplow, George B. Benedek ... Temperature dependence of amyloid β-protein fibrillization. Yoko Kusumoto, Aleksey Lomakin, David B. Teplow, George B. Benedek ... Temperature dependence of amyloid β-protein fibrillization. Yoko Kusumoto, Aleksey Lomakin, David B. Teplow, and George B. ... Fibrillogenesis of the amyloid β-protein (Aβ) is believed to play a central role in the pathogenesis of Alzheimers disease. ...
... amyloid β-protein (Aβ, see below) or its precursor, amyloid precursor protein and α-synuclein, respectively]. Thus, increasing ... Transthyretin amyloid diseases are protein-misfolding diseases where the normally folded tetrameric protein dissociates to an ... Transthyretin amyloid diseases are protein-misfolding diseases where the normally folded tetrameric protein dissociates to an ... Disease-Linked Mutations Localize to Fibril-Forming Proteins.. *AD-Associated Amyloid. Amyloid isolated from AD brain tissue ...
We combine protein signatures from a number of member databases into a single searchable resource, capitalising on their ... InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites ... Amyloid beta A4 protein (also known as APP or A4) consists of a large N-terminal extracellular region containing heparin- ... The amyloid precursor protein and postnatal neurogenesis/neuroregeneration.. Biochem. Biophys. Res. Commun. 341 1-5 2006 ...
Apple Procyanidins Suppress Amyloid -Protein Aggregation. Toshihiko Toda,1,2 Tadahiro Sunagawa,3 Tomomasa Kanda,3 Motoyuki ... we investigated the antiaggregative activity of PC on amyloid β-protein (Aβ) aggregation, which is a pathological hallmark of ...
Amyloid fibrils formed from prion protein (PrP) are associated with prion diseases. In this review we discuss a number of ... Sonication of proteins causes formation of aggregates that resemble amyloid. Protein Sci 13:3017-3027CrossRefPubMed ... Amyloid fibrils formed from prion protein (PrP) are associated with prion diseases. In this review we discuss a number of ... Eisenberg DS, Sawaya MR (2017) Structural studies of amyloid proteins at the molecular level. Annu Rev Biochem 86:69-95CrossRef ...
Our sequence pattern discovery and analysis approach unveiled protein regions of significant interest. AMYPdb is freely ... AMYPdb is a comprehensive online database aiming at the centralization of bioinformatic data regarding all amyloid proteins and ... AMYPdb: a database dedicated to amyloid precursor proteins BMC Bioinformatics. 2008 Jun 10;9:273. doi: 10.1186/1471-2105-9-273 ... Results: We therefore created a free online knowledge database (AMYPdb) dedicated to amyloid precursor proteins and we have ...
Here we identify the cellular prion protein (PrPC) as an amyloid-β-oligomer receptor by expression cloning. Amyloid-β oligomers ... paper shows that the effects of amyloid-beta oligomers on long-term potentiation are mediated by the cellular prion protein - ... Soluble amyloid-β oligomers have been prepared from chemical syntheses, transfected cell culture supernatants, transgenic mouse ... Synaptic responsiveness in hippocampal slices from young adult PrP null mice is normal, but the amyloid-β oligomer blockade of ...
beta-amyloid protein synonyms, beta-amyloid protein pronunciation, beta-amyloid protein translation, English dictionary ... definition of beta-amyloid protein. n. An amyloid that circulates in human blood and in cerebrospinal fluid and is deposited ... beta-amyloid protein. Also found in: Medical. be·ta-am·y·loid protein. (bā′tə-ăm′ə-loid′, bē′-). n.. An amyloid that circulates ... Beta-amyloid protein - definition of beta-amyloid protein by The Free Dictionary https://www.thefreedictionary.com/beta-amyloid ...
Amyloid beta-protein length and cerebral amyloid angiopathy-related haemorrhage.. McCarron MO1, Nicoll JA, Stewart J, Cole GM, ... The relationship between amyloid beta-protein (A beta) length and the apolipoprotein E (APOE) epsilon 2 allele, which is over- ... represented in cerebral amyloid angiopathy-related haemorrhage (CAAH), has not previously been examined. Of 57 CAA patients ...
"We were pleased to be able to identify amyloid proteins in 121 out of 131 attempted cases in this study, a success rate of 92 ... "This is a big step forward for amyloid patients because identifying the culprit protein is so important to delivering the right ... Associate Professor Michelle Hill from the UQ Diamantina Institute said different amyloid conditions had different protein ... "It is a challenging technique because of the small size of the protein deposits and the technical skills required for the ...
... Toshiyuki Yamada,1 Jyunji Sato,1 Kazuhiko Kotani,1 and ... Nicholas M. Frame, and Olga Gursky, "Structure of serum amyloid A suggests a mechanism for selective lipoprotein binding and ...
Serum amyloid A (SAA) is an acute phase inflammatory marker that is closely associated with ischemic injuries. Its expression ... Maury CP . Comparative study of serum amyloid A protein and C Reactive protein in disease. Clin Sci (Lond) 1985; 68: 233-238. ... Kristensen K, Wide-Swensson D, Lindstrom V, Schmidt C, Grubb A, Stevens H . Serum amyloid a protein and C- reactive protein in ... Chitinase-3-Like Protein 1, Serum Amyloid A1, C-Reactive Protein, and Procalcitonin Are Promising Biomarkers for Intracranial ...
NACP stands for New Amyloid Component Protein. NACP is defined as New Amyloid Component Protein very rarely. ... www.acronymfinder.com/New-Amyloid-Component-Protein-(NACP).html. *Chicago style: Acronym Finder. S.v. "NACP." Retrieved January ... www.acronymfinder.com/New-Amyloid-Component-Protein-(NACP).html,NACP,/a,. ... www.acronymfinder.com/New-Amyloid-Component-Protein-(NACP).html ... www.acronymfinder.com/New-Amyloid-Component-Protein-(NACP).html ...
  • Alnylam Pharmaceuticals and Sanofi have dissolved the partnership they formed to develop and market two treatments for the neurological disease familial amyloid polyneuropathy, or FAP. (fapnewstoday.com)
  • ATTR amyloidosis is another name for familial amyloid polyneuropathy. (fapnewstoday.com)
  • The clusters appeared as either irregular clumps or round or oval rosettes that strikingly resembled the neuritic component of Alzheimer amyloid plaques. (elsevier.com)
  • Neither APP/APLP2-immunoreactive clusters nor amyloid plaques were observed in the brain from patients with Wernicke- Korsakoff syndrome, the clinical manifestation of TD in man. (elsevier.com)
  • Amyloid beta (Abeta) peptides are hypothesized to cause the initiation and progression of AD based on pathologic data from AD patients, genetic analysis of mutations that cause early onset forms of AD, and preclinical studies. (geoscience.net)
  • Based on this hypothesis, beta-site amyloid precursor protein (APP)-cleaving enzyme 1 (BACE1) inhibitors are an attractive therapeutic approach for AD because cleavage of the APP by BACE1 is required to form Abeta. (geoscience.net)
  • These studies showed that all three BACE1 inhibitors decreased brain Abeta1-40 in P-gp KO mice, demonstrating that P-gp is a major limitation for development of BACE1 inhibitors to test the amyloid hypothesis. (geoscience.net)
  • Amyloid proteins build up in the arteries of the brain, which leads to an increased risk of dementia and stroke. (patientslikeme.com)
  • Other tests (Table 1 ) such as microbiologic and parasitologic analyses of the stools, T-SPOT.TB, bone biopsy and Bence-Jones protein test were all negative. (biomedcentral.com)
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