Radiotherapy, Image-Guided: The use of pre-treatment imaging modalities to position the patient, delineate the target, and align the beam of radiation to achieve optimal accuracy and reduce radiation damage to surrounding non-target tissues.Radiotherapy Planning, Computer-Assisted: Computer-assisted mathematical calculations of beam angles, intensities of radiation, and duration of irradiation in radiotherapy.Prostatic Neoplasms: Tumors or cancer of the PROSTATE.Radiotherapy: The use of IONIZING RADIATION to treat malignant NEOPLASMS and some benign conditions.Radiodermatitis: A cutaneous inflammatory reaction occurring as a result of exposure to ionizing radiation.Radiotherapy Dosage: The total amount of radiation absorbed by tissues as a result of radiotherapy.Prostate: A gland in males that surrounds the neck of the URINARY BLADDER and the URETHRA. It secretes a substance that liquefies coagulated semen. It is situated in the pelvic cavity behind the lower part of the PUBIC SYMPHYSIS, above the deep layer of the triangular ligament, and rests upon the RECTUM.Radiotherapy, Conformal: Radiotherapy where there is improved dose homogeneity within the tumor and reduced dosage to uninvolved structures. The precise shaping of dose distribution is achieved via the use of computer-controlled multileaf collimators.Radiation Injuries: Harmful effects of non-experimental exposure to ionizing or non-ionizing radiation in VERTEBRATES.Radiotherapy, Intensity-Modulated: CONFORMAL RADIOTHERAPY that combines several intensity-modulated beams to provide improved dose homogeneity and highly conformal dose distributions.Radiometry: The measurement of radiation by photography, as in x-ray film and film badge, by Geiger-Mueller tube, and by SCINTILLATION COUNTING.Prostate-Specific Antigen: A glycoprotein that is a kallikrein-like serine proteinase and an esterase, produced by epithelial cells of both normal and malignant prostate tissue. It is an important marker for the diagnosis of prostate cancer.ComputersRadiation Dosage: The amount of radiation energy that is deposited in a unit mass of material, such as tissues of plants or animal. In RADIOTHERAPY, radiation dosage is expressed in gray units (Gy). In RADIOLOGIC HEALTH, the dosage is expressed by the product of absorbed dose (Gy) and quality factor (a function of linear energy transfer), and is called radiation dose equivalent in sievert units (Sv).Radiotherapy, Adjuvant: Radiotherapy given to augment some other form of treatment such as surgery or chemotherapy. Adjuvant radiotherapy is commonly used in the therapy of cancer and can be administered before or after the primary treatment.Breast Neoplasms: Tumors or cancer of the human BREAST.Combined Modality Therapy: The treatment of a disease or condition by several different means simultaneously or sequentially. Chemoimmunotherapy, RADIOIMMUNOTHERAPY, chemoradiotherapy, cryochemotherapy, and SALVAGE THERAPY are seen most frequently, but their combinations with each other and surgery are also used.Androgen Antagonists: Compounds which inhibit or antagonize the biosynthesis or actions of androgens.Receptors, Androgen: Proteins, generally found in the CYTOPLASM, that specifically bind ANDROGENS and mediate their cellular actions. The complex of the androgen and receptor migrates to the CELL NUCLEUS where it induces transcription of specific segments of DNA.Cell Line, Tumor: A cell line derived from cultured tumor cells.Androgens: Compounds that interact with ANDROGEN RECEPTORS in target tissues to bring about the effects similar to those of TESTOSTERONE. Depending on the target tissues, androgenic effects can be on SEX DIFFERENTIATION; male reproductive organs, SPERMATOGENESIS; secondary male SEX CHARACTERISTICS; LIBIDO; development of muscle mass, strength, and power.Prostatectomy: Complete or partial surgical removal of the prostate. Three primary approaches are commonly employed: suprapubic - removal through an incision above the pubis and through the urinary bladder; retropubic - as for suprapubic but without entering the urinary bladder; and transurethral (TRANSURETHRAL RESECTION OF PROSTATE).Tomography, X-Ray Computed: Tomography using x-ray transmission and a computer algorithm to reconstruct the image.Radiotherapy, High-Energy: Radiotherapy using high-energy (megavolt or higher) ionizing radiation. Types of radiation include gamma rays, produced by a radioisotope within a teletherapy unit; x-rays, electrons, protons, alpha particles (helium ions) and heavy charged ions, produced by particle acceleration; and neutrons and pi-mesons (pions), produced as secondary particles following bombardment of a target with a primary particle.Neoplasm Staging: Methods which attempt to express in replicable terms the extent of the neoplasm in the patient.Prostatic Hyperplasia: Increase in constituent cells in the PROSTATE, leading to enlargement of the organ (hypertrophy) and adverse impact on the lower urinary tract function. This can be caused by increased rate of cell proliferation, reduced rate of cell death, or both.Gene Expression Regulation, Neoplastic: Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action in neoplastic tissue.Dose Fractionation: Administration of the total dose of radiation (RADIATION DOSAGE) in parts, at timed intervals.Orchiectomy: The surgical removal of one or both testicles.Adenocarcinoma: A malignant epithelial tumor with a glandular organization.Neoplasms, Hormone-Dependent: Certain tumors that 1, arise in organs that are normally dependent on specific hormones and 2, are stimulated or caused to regress by manipulation of the endocrine environment.Radiotherapy, Computer-Assisted: Computer systems or programs used in accurate computations for providing radiation dosage treatment to patients.Neoplasm Metastasis: The transfer of a neoplasm from one organ or part of the body to another remote from the primary site.Treatment Outcome: Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.Neoplasm Recurrence, Local: The local recurrence of a neoplasm following treatment. It arises from microscopic cells of the original neoplasm that have escaped therapeutic intervention and later become clinically visible at the original site.Tumor Markers, Biological: Molecular products metabolized and secreted by neoplastic tissue and characterized biochemically in cells or body fluids. They are indicators of tumor stage and grade as well as useful for monitoring responses to treatment and predicting recurrence. Many chemical groups are represented including hormones, antigens, amino and nucleic acids, enzymes, polyamines, and specific cell membrane proteins and lipids.Disease Progression: The worsening of a disease over time. This concept is most often used for chronic and incurable diseases where the stage of the disease is an important determinant of therapy and prognosis.Prognosis: A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.Early Detection of Cancer: Methods to identify and characterize cancer in the early stages of disease and predict tumor behavior.Mice, Nude: Mutant mice homozygous for the recessive gene "nude" which fail to develop a thymus. They are useful in tumor studies and studies on immune responses.Computer Simulation: Computer-based representation of physical systems and phenomena such as chemical processes.Brachytherapy: A collective term for interstitial, intracavity, and surface radiotherapy. It uses small sealed or partly-sealed sources that may be placed on or near the body surface or within a natural body cavity or implanted directly into the tissues.Antineoplastic Agents: Substances that inhibit or prevent the proliferation of NEOPLASMS.Bone Neoplasms: Tumors or cancer located in bone tissue or specific BONES.Lung Neoplasms: Tumors or cancer of the LUNG.Retrospective Studies: Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.Survival Rate: The proportion of survivors in a group, e.g., of patients, studied and followed over a period, or the proportion of persons in a specified group alive at the beginning of a time interval who survive to the end of the interval. It is often studied using life table methods.Follow-Up Studies: Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.Neoplasm Invasiveness: Ability of neoplasms to infiltrate and actively destroy surrounding tissue.Survival Analysis: A class of statistical procedures for estimating the survival function (function of time, starting with a population 100% well at a given time and providing the percentage of the population still well at later times). The survival analysis is then used for making inferences about the effects of treatments, prognostic factors, exposures, and other covariates on the function.Radiation Oncology: A subspecialty of medical oncology and radiology concerned with the radiotherapy of cancer.Prostatic Intraepithelial Neoplasia: A premalignant change arising in the prostatic epithelium, regarded as the most important and most likely precursor of prostatic adenocarcinoma. The neoplasia takes the form of an intra-acinar or ductal proliferation of secretory cells with unequivocal nuclear anaplasia, which corresponds to nuclear grade 2 and 3 invasive prostate cancer.Neoplasm Grading: Methods which attempt to express in replicable terms the level of CELL DIFFERENTIATION in neoplasms as increasing ANAPLASIA correlates with the aggressiveness of the neoplasm.Antineoplastic Combined Chemotherapy Protocols: The use of two or more chemicals simultaneously or sequentially in the drug therapy of neoplasms. The drugs need not be in the same dosage form.Disease-Free Survival: Period after successful treatment in which there is no appearance of the symptoms or effects of the disease.Neoplasms: New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.Tosyl CompoundsAntineoplastic Agents, Hormonal: Antineoplastic agents that are used to treat hormone-sensitive tumors. Hormone-sensitive tumors may be hormone-dependent, hormone-responsive, or both. A hormone-dependent tumor regresses on removal of the hormonal stimulus, by surgery or pharmacological block. Hormone-responsive tumors may regress when pharmacologic amounts of hormones are administered regardless of whether previous signs of hormone sensitivity were observed. The major hormone-responsive cancers include carcinomas of the breast, prostate, and endometrium; lymphomas; and certain leukemias. (From AMA Drug Evaluations Annual 1994, p2079)Cell Proliferation: All of the processes involved in increasing CELL NUMBER including CELL DIVISION.Risk Factors: An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.Apoptosis: One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.Tumor Cells, Cultured: Cells grown in vitro from neoplastic tissue. If they can be established as a TUMOR CELL LINE, they can be propagated in cell culture indefinitely.Carcinoma: A malignant neoplasm made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases. It is a histological type of neoplasm but is often wrongly used as a synonym for "cancer." (From Dorland, 27th ed)Dose-Response Relationship, Radiation: The relationship between the dose of administered radiation and the response of the organism or tissue to the radiation.Xenograft Model Antitumor Assays: In vivo methods of screening investigative anticancer drugs, biologic response modifiers or radiotherapies. Human tumor tissue or cells are transplanted into mice or rats followed by tumor treatment regimens. A variety of outcomes are monitored to assess antitumor effectiveness.Head and Neck Neoplasms: Soft tissue tumors or cancer arising from the mucosal surfaces of the LIP; oral cavity; PHARYNX; LARYNX; and cervical esophagus. Other sites included are the NOSE and PARANASAL SINUSES; SALIVARY GLANDS; THYROID GLAND and PARATHYROID GLANDS; and MELANOMA and non-melanoma skin cancers of the head and neck. (from Holland et al., Cancer Medicine, 4th ed, p1651)Prospective Studies: Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.Neoplasm Proteins: Proteins whose abnormal expression (gain or loss) are associated with the development, growth, or progression of NEOPLASMS. Some neoplasm proteins are tumor antigens (ANTIGENS, NEOPLASM), i.e. they induce an immune reaction to their tumor. Many neoplasm proteins have been characterized and are used as tumor markers (BIOMARKERS, TUMOR) when they are detectable in cells and body fluids as monitors for the presence or growth of tumors. Abnormal expression of ONCOGENE PROTEINS is involved in neoplastic transformation, whereas the loss of expression of TUMOR SUPPRESSOR PROTEINS is involved with the loss of growth control and progression of the neoplasm.Carcinoma, Squamous Cell: A carcinoma derived from stratified SQUAMOUS EPITHELIAL CELLS. It may also occur in sites where glandular or columnar epithelium is normally present. (From Stedman, 25th ed)Time Factors: Elements of limited time intervals, contributing to particular results or situations.Genetic Predisposition to Disease: A latent susceptibility to disease at the genetic level, which may be activated under certain conditions.Reverse Transcriptase Polymerase Chain Reaction: A variation of the PCR technique in which cDNA is made from RNA via reverse transcription. The resultant cDNA is then amplified using standard PCR protocols.Androgen Receptor Antagonists: Compounds that bind to and inhibit the activation of ANDROGEN RECEPTORS.Neoplasm Transplantation: Experimental transplantation of neoplasms in laboratory animals for research purposes.Radiation Tolerance: The ability of some cells or tissues to survive lethal doses of IONIZING RADIATION. Tolerance depends on the species, cell type, and physical and chemical variables, including RADIATION-PROTECTIVE AGENTS and RADIATION-SENSITIZING AGENTS.Immunohistochemistry: Histochemical localization of immunoreactive substances using labeled antibodies as reagents.AnilidesWatchful Waiting: Clinical management approach wherein immediate therapy is not provided but there is a period of observation during which periodic tests monitor patient and the progression of the illness. (Driffield T, Smith PC Med Decis Making. 2007 Mar-Apr;27(2):178-88)Radiosurgery: A radiological stereotactic technique developed for cutting or destroying tissue by high doses of radiation in place of surgical incisions. It was originally developed for neurosurgery on structures in the brain and its use gradually spread to radiation surgery on extracranial structures as well. The usual rigid needles or probes of stereotactic surgery are replaced with beams of ionizing radiation directed toward a target so as to achieve local tissue destruction.Digital Rectal Examination: A physical examination in which the qualified health care worker inserts a lubricated, gloved finger of one hand into the RECTUM and may use the other hand to press on the lower ABDOMEN or pelvic area to palpate for abnormalities in the lower rectum, and nearby organs or tissues. The method is commonly used to check the lower rectum, the PROSTATE gland in men, and the UTERUS and OVARIES in women.RNA, Messenger: RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.Transplantation, Heterologous: Transplantation between animals of different species.Risk: The probability that an event will occur. It encompasses a variety of measures of the probability of a generally unfavorable outcome.Rectal Neoplasms: Tumors or cancer of the RECTUM.Chemotherapy, Adjuvant: Drug therapy given to augment or stimulate some other form of treatment such as surgery or radiation therapy. Adjuvant chemotherapy is commonly used in the therapy of cancer and can be administered before or after the primary treatment.Tumor Burden: The total amount (cell number, weight, size or volume) of tumor cells or tissue in the body.Risk Assessment: The qualitative or quantitative estimation of the likelihood of adverse effects that may result from exposure to specified health hazards or from the absence of beneficial influences. (Last, Dictionary of Epidemiology, 1988)Attitude to Computers: The attitude and behavior associated with an individual using the computer.Dihydrotestosterone: A potent androgenic metabolite of TESTOSTERONE. It is produced by the action of the enzyme 3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE.Sensitivity and Specificity: Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)Case-Control Studies: Studies which start with the identification of persons with a disease of interest and a control (comparison, referent) group without the disease. The relationship of an attribute to the disease is examined by comparing diseased and non-diseased persons with regard to the frequency or levels of the attribute in each group.Biopsy: Removal and pathologic examination of specimens in the form of small pieces of tissue from the living body.Finasteride: An orally active 3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE inhibitor. It is used as a surgical alternative for treatment of benign PROSTATIC HYPERPLASIA.Chemoradiotherapy: Treatment that combines chemotherapy with radiotherapy.Radiation-Sensitizing Agents: Drugs used to potentiate the effectiveness of radiation therapy in destroying unwanted cells.Gene Expression Profiling: The determination of the pattern of genes expressed at the level of GENETIC TRANSCRIPTION, under specific circumstances or in a specific cell.Blotting, Western: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.Cisplatin: An inorganic and water-soluble platinum complex. After undergoing hydrolysis, it reacts with DNA to produce both intra and interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity of cisplatin correlates with cellular arrest in the G2 phase of the cell cycle.Flutamide: An antiandrogen with about the same potency as cyproterone in rodent and canine species.Brain Neoplasms: Neoplasms of the intracranial components of the central nervous system, including the cerebral hemispheres, basal ganglia, hypothalamus, thalamus, brain stem, and cerebellum. Brain neoplasms are subdivided into primary (originating from brain tissue) and secondary (i.e., metastatic) forms. Primary neoplasms are subdivided into benign and malignant forms. In general, brain tumors may also be classified by age of onset, histologic type, or presenting location in the brain.Kaplan-Meier Estimate: A nonparametric method of compiling LIFE TABLES or survival tables. It combines calculated probabilities of survival and estimates to allow for observations occurring beyond a measurement threshold, which are assumed to occur randomly. Time intervals are defined as ending each time an event occurs and are therefore unequal. (From Last, A Dictionary of Epidemiology, 1995)Signal Transduction: The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.Taxoids: A group of diterpenoid CYCLODECANES named for the taxanes that were discovered in the TAXUS tree. The action on MICROTUBULES has made some of them useful as ANTINEOPLASTIC AGENTS.Drug Resistance, Neoplasm: Resistance or diminished response of a neoplasm to an antineoplastic agent in humans, animals, or cell or tissue cultures.United StatesCohort Studies: Studies in which subsets of a defined population are identified. These groups may or may not be exposed to factors hypothesized to influence the probability of the occurrence of a particular disease or other outcome. Cohorts are defined populations which, as a whole, are followed in an attempt to determine distinguishing subgroup characteristics.Cell Survival: The span of viability of a cell characterized by the capacity to perform certain functions such as metabolism, growth, reproduction, some form of responsiveness, and adaptability.Organs at Risk: Organs which might be damaged during exposure to a toxin or to some form of therapy. It most frequently refers to healthy organs located in the radiation field during radiation therapy.Metribolone: A synthetic non-aromatizable androgen and anabolic steroid. It binds strongly to the androgen receptor and has therefore also been used as an affinity label for this receptor in the prostate and in prostatic tumors.Transurethral Resection of Prostate: Removal of all or part of the PROSTATE, often using a cystoscope and/or resectoscope passed through the URETHRA.Ovarian Neoplasms: Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS.Uterine Cervical Neoplasms: Tumors or cancer of the UTERINE CERVIX.Multivariate Analysis: A set of techniques used when variation in several variables has to be studied simultaneously. In statistics, multivariate analysis is interpreted as any analytic method that allows simultaneous study of two or more dependent variables.Cell Growth Processes: Processes required for CELL ENLARGEMENT and CELL PROLIFERATION.Incidence: The number of new cases of a given disease during a given period in a specified population. It also is used for the rate at which new events occur in a defined population. It is differentiated from PREVALENCE, which refers to all cases, new or old, in the population at a given time.RNA, Small Interfering: Small double-stranded, non-protein coding RNAs (21-31 nucleotides) involved in GENE SILENCING functions, especially RNA INTERFERENCE (RNAi). Endogenously, siRNAs are generated from dsRNAs (RNA, DOUBLE-STRANDED) by the same ribonuclease, Dicer, that generates miRNAs (MICRORNAS). The perfect match of the siRNAs' antisense strand to their target RNAs mediates RNAi by siRNA-guided RNA cleavage. siRNAs fall into different classes including trans-acting siRNA (tasiRNA), repeat-associated RNA (rasiRNA), small-scan RNA (scnRNA), and Piwi protein-interacting RNA (piRNA) and have different specific gene silencing functions.Biopsy, Needle: Removal and examination of tissue obtained through a transdermal needle inserted into the specific region, organ, or tissue being analyzed.Reproducibility of Results: The statistical reproducibility of measurements (often in a clinical context), including the testing of instrumentation or techniques to obtain reproducible results. The concept includes reproducibility of physiological measurements, which may be used to develop rules to assess probability or prognosis, or response to a stimulus; reproducibility of occurrence of a condition; and reproducibility of experimental results.Cell Division: The fission of a CELL. It includes CYTOKINESIS, when the CYTOPLASM of a cell is divided, and CELL NUCLEUS DIVISION.Prostatic Neoplasms, Castration-Resistant: Tumors or cancer of the PROSTATE which can grow in the presence of low or residual amount of androgen hormones such as TESTOSTERONE.Cancer Vaccines: Vaccines or candidate vaccines designed to prevent or treat cancer. Vaccines are produced using the patient's own whole tumor cells as the source of antigens, or using tumor-specific antigens, often recombinantly produced.Down-Regulation: A negative regulatory effect on physiological processes at the molecular, cellular, or systemic level. At the molecular level, the major regulatory sites include membrane receptors, genes (GENE EXPRESSION REGULATION), mRNAs (RNA, MESSENGER), and proteins.Carcinoma, Non-Small-Cell Lung: A heterogeneous aggregate of at least three distinct histological types of lung cancer, including SQUAMOUS CELL CARCINOMA; ADENOCARCINOMA; and LARGE CELL CARCINOMA. They are dealt with collectively because of their shared treatment strategy.Anticarcinogenic Agents: Agents that reduce the frequency or rate of spontaneous or induced tumors independently of the mechanism involved.Genotype: The genetic constitution of the individual, comprising the ALLELES present at each GENETIC LOCUS.Colonic Neoplasms: Tumors or cancer of the COLON.Age Factors: Age as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or the effect of a circumstance. It is used with human or animal concepts but should be differentiated from AGING, a physiological process, and TIME FACTORS which refers only to the passage of time.Nasopharyngeal Neoplasms: Tumors or cancer of the NASOPHARYNX.Computer Peripherals: Various units or machines that operate in combination or in conjunction with a computer but are not physically part of it. Peripheral devices typically display computer data, store data from the computer and return the data to the computer on demand, prepare data for human use, or acquire data from a source and convert it to a form usable by a computer. (Computer Dictionary, 4th ed.)Neoplasms, Radiation-Induced: Tumors, cancer or other neoplasms produced by exposure to ionizing or non-ionizing radiation.Predictive Value of Tests: In screening and diagnostic tests, the probability that a person with a positive test is a true positive (i.e., has the disease), is referred to as the predictive value of a positive test; whereas, the predictive value of a negative test is the probability that the person with a negative test does not have the disease. Predictive value is related to the sensitivity and specificity of the test.Stomach Neoplasms: Tumors or cancer of the STOMACH.Odds Ratio: The ratio of two odds. The exposure-odds ratio for case control data is the ratio of the odds in favor of exposure among cases to the odds in favor of exposure among noncases. The disease-odds ratio for a cohort or cross section is the ratio of the odds in favor of disease among the exposed to the odds in favor of disease among the unexposed. The prevalence-odds ratio refers to an odds ratio derived cross-sectionally from studies of prevalent cases.Neoplasms, Second Primary: Abnormal growths of tissue that follow a previous neoplasm but are not metastases of the latter. The second neoplasm may have the same or different histological type and can occur in the same or different organs as the previous neoplasm but in all cases arises from an independent oncogenic event. The development of the second neoplasm may or may not be related to the treatment for the previous neoplasm since genetic risk or predisposing factors may actually be the cause.SEER Program: A cancer registry mandated under the National Cancer Act of 1971 to operate and maintain a population-based cancer reporting system, reporting periodically estimates of cancer incidence and mortality in the United States. The Surveillance, Epidemiology, and End Results (SEER) Program is a continuing project of the National Cancer Institute of the National Institutes of Health. Among its goals, in addition to assembling and reporting cancer statistics, are the monitoring of annual cancer incident trends and the promoting of studies designed to identify factors amenable to cancer control interventions. (From National Cancer Institute, NIH Publication No. 91-3074, October 1990)Quality of Life: A generic concept reflecting concern with the modification and enhancement of life attributes, e.g., physical, political, moral and social environment; the overall condition of a human life.DNA, Neoplasm: DNA present in neoplastic tissue.Mice, SCID: Mice homozygous for the mutant autosomal recessive gene "scid" which is located on the centromeric end of chromosome 16. These mice lack mature, functional lymphocytes and are thus highly susceptible to lethal opportunistic infections if not chronically treated with antibiotics. The lack of B- and T-cell immunity resembles severe combined immunodeficiency (SCID) syndrome in human infants. SCID mice are useful as animal models since they are receptive to implantation of a human immune system producing SCID-human (SCID-hu) hematochimeric mice.Pancreatic Neoplasms: Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.Glutamate Carboxypeptidase II: A metallocarboxypeptidase that is predominantly expressed as a membrane-bound enzyme. It catalyzes the hydrolysis of an unsubstituted, C-terminal glutamyl residue, typically from PTEROYLPOLYGLUTAMIC ACIDS. It was formerly classified as EC 3.4.19.8.Antineoplastic Agents, Phytogenic: Agents obtained from higher plants that have demonstrable cytostatic or antineoplastic activity.Models, Biological: Theoretical representations that simulate the behavior or activity of biological processes or diseases. For disease models in living animals, DISEASE MODELS, ANIMAL is available. Biological models include the use of mathematical equations, computers, and other electronic equipment.Dose-Response Relationship, Drug: The relationship between the dose of an administered drug and the response of the organism to the drug.Computer Literacy: Familiarity and comfort in using computers efficiently.5-alpha Reductase Inhibitors: Drugs that inhibit 3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE. They are commonly used to reduce the production of DIHYDROTESTOSTERONE.PTEN Phosphohydrolase: A lipid phosphatase that acts on phosphatidylinositol-3,4,5-trisphosphate to regulate various SIGNAL TRANSDUCTION PATHWAYS. It modulates CELL GROWTH PROCESSES; CELL MIGRATION; and APOPTOSIS. Mutations in PTEN are associated with COWDEN DISEASE and PROTEUS SYNDROME as well as NEOPLASTIC CELL TRANSFORMATION.Cell Movement: The movement of cells from one location to another. Distinguish from CYTOKINESIS which is the process of dividing the CYTOPLASM of a cell.Questionnaires: Predetermined sets of questions used to collect data - clinical data, social status, occupational group, etc. The term is often applied to a self-completed survey instrument.Particle Accelerators: Devices which accelerate electrically charged atomic or subatomic particles, such as electrons, protons or ions, to high velocities so they have high kinetic energy.Oligonucleotide Array Sequence Analysis: Hybridization of a nucleic acid sample to a very large set of OLIGONUCLEOTIDE PROBES, which have been attached individually in columns and rows to a solid support, to determine a BASE SEQUENCE, or to detect variations in a gene sequence, GENE EXPRESSION, or for GENE MAPPING.Clinical Trials as Topic: Works about pre-planned studies of the safety, efficacy, or optimum dosage schedule (if appropriate) of one or more diagnostic, therapeutic, or prophylactic drugs, devices, or techniques selected according to predetermined criteria of eligibility and observed for predefined evidence of favorable and unfavorable effects. This concept includes clinical trials conducted both in the U.S. and in other countries.Registries: The systems and processes involved in the establishment, support, management, and operation of registers, e.g., disease registers.Transfection: The uptake of naked or purified DNA by CELLS, usually meaning the process as it occurs in eukaryotic cells. It is analogous to bacterial transformation (TRANSFORMATION, BACTERIAL) and both are routinely employed in GENE TRANSFER TECHNIQUES.Palliative Care: Care alleviating symptoms without curing the underlying disease. (Stedman, 25th ed)Computer Systems: Systems composed of a computer or computers, peripheral equipment, such as disks, printers, and terminals, and telecommunications capabilities.DNA Methylation: Addition of methyl groups to DNA. DNA methyltransferases (DNA methylases) perform this reaction using S-ADENOSYLMETHIONINE as the methyl group donor.Cell Cycle: The complex series of phenomena, occurring between the end of one CELL DIVISION and the end of the next, by which cellular material is duplicated and then divided between two daughter cells. The cell cycle includes INTERPHASE, which includes G0 PHASE; G1 PHASE; S PHASE; and G2 PHASE, and CELL DIVISION PHASE.Promoter Regions, Genetic: DNA sequences which are recognized (directly or indirectly) and bound by a DNA-dependent RNA polymerase during the initiation of transcription. Highly conserved sequences within the promoter include the Pribnow box in bacteria and the TATA BOX in eukaryotes.Survivors: Persons who have experienced a prolonged survival after serious disease or who continue to live with a usually life-threatening condition as well as family members, significant others, or individuals surviving traumatic life events.National Cancer Institute (U.S.): Component of the NATIONAL INSTITUTES OF HEALTH. Through basic and clinical biomedical research and training, it conducts and supports research with the objective of cancer prevention, early stage identification and elimination. This Institute was established in 1937.Up-Regulation: A positive regulatory effect on physiological processes at the molecular, cellular, or systemic level. At the molecular level, the major regulatory sites include membrane receptors, genes (GENE EXPRESSION REGULATION), mRNAs (RNA, MESSENGER), and proteins.Antigens, Neoplasm: Proteins, glycoprotein, or lipoprotein moieties on surfaces of tumor cells that are usually identified by monoclonal antibodies. Many of these are of either embryonic or viral origin.Tissue Array Analysis: The simultaneous analysis of multiple samples of TISSUES or CELLS from BIOPSY or in vitro culture that have been arranged in an array format on slides or microchips.Mutation: Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.Urinary Bladder Neoplasms: Tumors or cancer of the URINARY BLADDER.Cell Transformation, Neoplastic: Cell changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm, and other attributes conferring the ability to invade, metastasize, and kill.Rectum: The distal segment of the LARGE INTESTINE, between the SIGMOID COLON and the ANAL CANAL.Algorithms: A procedure consisting of a sequence of algebraic formulas and/or logical steps to calculate or determine a given task.Feasibility Studies: Studies to determine the advantages or disadvantages, practicability, or capability of accomplishing a projected plan, study, or project.Nomograms: Graphical representation of a statistical model containing scales for calculating the prognostic weight of a value for each individual variable. Nomograms are instruments that can be used to predict outcomes using specific clinical parameters. They use ALGORITHMS that incorporate several variables to calculate the predicted probability that a patient will achieve a particular clinical endpoint.Polymorphism, Genetic: The regular and simultaneous occurrence in a single interbreeding population of two or more discontinuous genotypes. The concept includes differences in genotypes ranging in size from a single nucleotide site (POLYMORPHISM, SINGLE NUCLEOTIDE) to large nucleotide sequences visible at a chromosomal level.Castration: Surgical removal or artificial destruction of gonads.Testosterone Congeners: Steroidal compounds related to TESTOSTERONE, the major mammalian male sex hormone. Testosterone congeners include important testosterone precursors in the biosynthetic pathways, metabolites, derivatives, and synthetic steroids with androgenic activities.Tumor Suppressor Protein p53: Nuclear phosphoprotein encoded by the p53 gene (GENES, P53) whose normal function is to control CELL PROLIFERATION and APOPTOSIS. A mutant or absent p53 protein has been found in LEUKEMIA; OSTEOSARCOMA; LUNG CANCER; and COLORECTAL CANCER.Drug Administration Schedule: Time schedule for administration of a drug in order to achieve optimum effectiveness and convenience.Esophageal Neoplasms: Tumors or cancer of the ESOPHAGUS.Nitriles: Organic compounds containing the -CN radical. The concept is distinguished from CYANIDES, which denotes inorganic salts of HYDROGEN CYANIDE.Prostatic Diseases: Pathological processes involving the PROSTATE or its component tissues.Neovascularization, Pathologic: A pathologic process consisting of the proliferation of blood vessels in abnormal tissues or in abnormal positions.Molecular Targeted Therapy: Treatments with drugs which interact with or block synthesis of specific cellular components characteristic of the individual's disease in order to stop or interrupt the specific biochemical dysfunction involved in progression of the disease.Logistic Models: Statistical models which describe the relationship between a qualitative dependent variable (that is, one which can take only certain discrete values, such as the presence or absence of a disease) and an independent variable. A common application is in epidemiology for estimating an individual's risk (probability of a disease) as a function of a given risk factor.Testosterone: A potent androgenic steroid and major product secreted by the LEYDIG CELLS of the TESTIS. Its production is stimulated by LUTEINIZING HORMONE from the PITUITARY GLAND. In turn, testosterone exerts feedback control of the pituitary LH and FSH secretion. Depending on the tissues, testosterone can be further converted to DIHYDROTESTOSTERONE or ESTRADIOL.Polymerase Chain Reaction: In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.European Continental Ancestry Group: Individuals whose ancestral origins are in the continent of Europe.

*Cyberknife

"Is CyberKnife Ready for Prime Time in Prostate Cancer?". WSJ. 28 November 2008 Gerszten, P. C.; Ozhasoglu, C; Burton, S. A.; ... a radiation oncologist must plan the delivery of the radiation using a dedicated computer program, after which the treatment ... sdcyberknife.com Fuller CD; Scarbrough TJ (2006). "Fiducial Markers in Image-guided Radiotherapy of the Prostate". US ... The International Journal of Medical Robotics and Computer Assisted Surgery. 1 (2): 19-27. doi:10.1002/rcs.38. PMID 17518375. ...

*Radiation therapy

... head and neck cancer, breast cancer, non-small cell lung cancer, cervical cancer, anal cancer, prostate cancer. Metastatic ... be applied is frequently missed due to the complex localization of the wound cavity even when modern radiotherapy planning is ... Computer-controlled x-ray accelerators distribute precise radiation doses to malignant tumors or specific areas within the ... However, the use of assisted reproductive technologies and micromanipulation techniques might increase this risk. ...
Everything you need to know about image guided radiotherapy (igrt). What is (image guided radiotherapy (igrt)) y en qué consiste?
TY - JOUR. T1 - Patterns of relapse following radiotherapy for differentiated thyroid cancer. T2 - Implication for target volume delineation. AU - Azrif, Muhammad. AU - Slevin, Nicholas J.. AU - Sykes, Andrew J.. AU - Swindell, Ric. AU - Yap, Beng K.. PY - 2008/10. Y1 - 2008/10. N2 - Introduction: Post-operative residual disease in differentiated thyroid cancer is an indication for external beam radiotherapy (EBRT) especially if there is poor radioiodine uptake by the residual disease. There are no standardized guidelines or consensus in target delineation for radiotherapy in thyroid cancer. Aims: To determine the pattern of recurrence in patients with well differentiated thyroid cancer who received adjuvant or definitive radiotherapy as well as radioiodine ablation following surgery or biopsy with a view to better defining future target volume delineation for ...
The global move towards more conformal radiotherapy for rectal cancer requires better imaging modalities that both visualise the disease accurately and are reproducible; to reduce interobserver variation. This review explores the advances in imaging modalities used in target volume delineation, with a view to make recommendations for current clinical practice and to propose future directions for research. A systematic review was conducted using MEDLINE and EMBASE. Articles considered relevant by the authors were included. Planning with orthogonal films is being replaced by computed tomography (CT) simulation. This is now considered the gold standard and allows conformal three-dimensional planning. Magnetic resonance imaging (MRI) has been shown to overcome some of the limitations of CT and can be used either as a diagnostic image to visually aid planning, or as a planning MRI carried out in the treatment ...
Image-guided radiotherapy (IGRT) uses advanced imaging techniques to improve the accuracy of radiotherapy delivery to the target tumor, allowing more accurate and precise targeting of the treatment volume.
Franks, K. N., McNair, H. A. (2012) Implementation of Image-guided Radiotherapy. CLINICAL ONCOLOGY, 24 (9). pp. 625-626. ISSN 0936-6555 ...
TY - JOUR. T1 - SU‐GG‐T‐537. T2 - Dosimetric Effect of Residual Tumor Motion in Phase and Amplitude‐Based Gated Lung Stereotactic Body Radiotherapy. AU - Zhao, B.. AU - Yang, Y.. AU - Heron, D.. AU - Huq, M.. PY - 2010. Y1 - 2010. N2 - Purpose To evaluate dosimetric effect of residual tumor motion in lung Stereotactic Body Radiotherapy(SBRT) with two gating methods using external markers: amplitude‐(AG) and phase‐based(PG). Methods and Materials The 3D tumor motion data were obtained from the treatment logs of 6 lung patients with various target size, each treated with 3 fractions of SBRT using Cyberknife Robotic Radiosurgical System and Synchrony™(Accuray, Sunnyvale CA). Amplitude and phase‐based gating treatments were simulated with a gating window of 5 mm. Planning target volume(PTV) was defined as physician‐contoured clinical target volume(CTV) surrounded by isotropic 5 mm margin. Each patient was prescribed with 60Gy/3fractions prescribed to 80% isodose ...
inproceedings{391142, author = {Crop, Frederik and Reynaert, Nick and De Gersem, Werner and Pittomvils, Geert and COGHE, MARC and De Neve, Wilfried and Vakaet, Luc and Thierens, Hubert}, booktitle = {RADIOTHERAPY AND ONCOLOGY}, issn = {0167-8140}, language = {eng}, pages = {S419-S419}, publisher = {ELSEVIER IRELAND LTD}, title = {Implementation and validation of an add-on MLC for Monte Carlo dose calculations in conformal stereotactic radiosurgery}, volume = {81}, year = {2006 ...
Results In total, 13 patients had 47 FM inserted under EUS guidance. Immediate CXR visualisation of FM was seen in 43/49 (88%). EUS guided FM insertion was feasible in all patients, no adverse events reported. Only 11 patients were eventually fit to undergo radiotherapy, of which data was available on 8 patients who received Radical 3 D conformal RT with 50 Gy. Markers were visualised in 21/27 (75%) on CT planning and during IGRT at treatment delivery using cone-beam CTs. Migration of the FM was seen with 2 markers, close to the actual lesion (in 2 patients).. FM derived gross tumour length (GTV) on planning CT was similar to endoscopic tumour length (7.4 cm vs 8 cm). Mean GTV volume was 40.09 cubic cm (range: 18.57-80.1). Mean GTV length was 7.4 cm (range: 3.75-11.3). Mean PTV volume was 252.07 cubic cm (range: 135.4-357.2). Mean V20 for Lung was 19.16% (range: 13.1-28.37). FM assisted significantly in RT planning for ...
|p||i||b|Radiation Therapy Treatment Effects|/b||/i| is a practical guide to common and uncommon toxicities which occur related to radiation therapy. Organized by anatomic region, from CNS to skin and extremities, this handbook concisely and comprehensive
If you have a question about this talk, please contact Mala Jayasundera.. Host: Professor Neil Burnet. Abstract not available. This talk is part of the Cambridge Oncology Seminar Series series.. ...
Inter-observer variation is a well-known problem in medical practice. Gardenia et al. first reported on this issue in the 1950 s [3], and it became a subject for discussion in the radiotherapeutic community in the 1970 s. In the 1990 s, many articles were published about inter-observer variation for a variety of cancers: prostate cancer [4], brain tumors [5], breast cancer [6] head and neck cancer [12, 13], and lung cancer [14, 15]. However, we were unable to find any papers that examined inter-observer variation for pituitary adenoma and meningioma; to the best of our knowledge, this is the first such report.. DVHs analysis by superimposing different contours from multiple clinicians onto the default treatment plan showed higher maximal dose for optic tract (Figure 3). It was increased to 23.64 Gy (268% higher dose than default plan) for the pituitary adenoma and 19.39 Gy (131%) for the meningioma. These ...
Image-guided radiation therapy (IGRT) is the process of frequent two and three-dimensional imaging, during a course of radiation treatment, used to direct radiation therapy utilizing the imaging coordinates of the actual radiation treatment plan. The patient is localized in the treatment room in the same position as planned from the reference imaging dataset. An example of IGRT would include localization of a cone beam computed tomography (CBCT) dataset with the planning computed tomography (CT) dataset from planning. IGRT would also include matching planar kilovoltage (kV) radiographs or megavoltage (MV) images with digital reconstructed radiographs (DRRs) from the planning CT. These two methods comprise the bulk of IGRT strategies currently employed circa 2013. This process is distinct from the use of imaging to delineate targets and organs in the planning process of radiation therapy. However, there is clearly a connection between the ...
0028] FIG. 3 shows components 301-308, as well as dependencies between these components. A Guidance System Controller component 301 is the top-level component for the facility. The Guidance System Controller component acts as a registry for the various services, and represents the entire facility. A Target Tracker component 302 tracks the target isocenter of the patient by integrating the location of a sensor array provided by an Array Tracker component 303 with magnetic transponder locations provided by a Front-End Controller component 304. Target isocenter tracking information may be used in a variety of ways, such as those described in U.S. Patent Application No. 60/590,693 filed Jul. 23, 2004, U.S. patent application Ser. No. 11/190,205, filed Jul. 25, 2005, and entitled DATA PROCESSING FOR REAL-TIME TRACKING OF A TARGET IN RADIATION THERAPY, U.S. Patent Application No. 60/590,503 filed Jul. 23, 2004, and U.S. patent application Ser. No. 11/189,431, filed Jul. 25, 2005, and entitled ...
In summary, the overall prognosis of glioblastoma (GBM) patients remains poor. Although clinical gains have been achieved in the past, these have been modest, with a majority of patients succumbing to local disease progression within 2 years. New strategies for treatment need to be identified which enhance local control above the current treatment regimen in order to achieve further clinical gains in this disease. Favorable early experience with magnetic resonance spectroscopy imaging (MRSI) demonstrates that metabolic imaging can identify active tumor beyond standard MRI as well as high risk regions at risk for local failure. There is also clinical evidence that limited field dose escalation with either simultaneous integrated boost (SIB) or stereotactic radiosurgery (SRS) is feasible and safe. Coupling these findings provide the rationale for this proposed Phase II trial designed to define efficacy and toxicity of the novel treatment approach of whole brain volumetric 3D MRSI guided ...
An apparatus comprising a radiation source, coincident positron emission detectors configured to detect coincident positron annihilation emissions originating within a coordinate system, and a controller coupled to the radiation source and the coincident positron emission detectors, the controller configured to identify coincident positron annihilation emission paths intersecting one or more volumes in the coordinate system and align the radiation source along an identified coincident positron annihilation emission path.
0145]The excitation source 1010 illustrated in FIG. 20 alternately energizes the source coils 1052a-d during an excitation phase to power the markers 40, and then actively de-energizes the source coils 1052a-d during a sensing phase in which the sensor assembly 1012 senses the decaying location signals wirelessly transmitted by the markers 40. To actively energize and de-energize the source coils 1052a-d, the switching network 1044 is configured to alternatively transfer stored energy from the energy storage device 1042 to the source coils 1052a-d, and to then re-transfer energy from the source coils 1052a-d back to the energy storage device 1042. The switching network 1044 alternates between first and second "on" positions so that the voltage across the source coils 1052 alternates between positive and negative polarities. For example, when the switching network 1044 is switched to the first "on" position, the energy in the energy storage device 1042 flows to the source coils 1052a-d. When the ...
Overtreatment as a crucial modern medicine issue needs to be urgently addressed. Theranostic agents supply a unique platform and integrate multiple diagnosis and therapies to deal with this issue. In this study, a core-shell [email protected] nanostructure was fabricated via two step reactions for tri-modal imaging
Increasing the power of tumour control and normal tissue complication probability modelling in radiotherapy: recent trends and current issues
Purpose: To study the impact of clinical predisposing factors on rectal normal tissue complication probability modeling using the updated results of the Dutch prostate dose-escalation trial. Methods and Materials: Toxicity data of 512 patients (conformally treated to 68 Gy [n = 284] and 78 Gy [n = 228]) with complete follow-up at 3 years after radiotherapy were studied. Scored end points were rectal bleeding, high stool frequency, and fecal incontinence. Two traditional dose-based models (Lyman-Kutcher-Burman (LKB) and Relative Seriality (RS) and a logistic model were fitted using a maximum likelihood approach. Furthermore, these model fits were improved by including the most significant clinical factors. The area under the receiver operating characteristic curve (AUC) was used to compare the discriminating ability of all fits. Results: Including clinical factors significantly increased the predictive power of the models for all end points. In the optimal LKB, RS, and ...
Purpose: Compressed sensing (CS)-based iterative reconstruction (IR) techniques are able to reconstruct cone-beam CT (CBCT) images from undersampled noisy data, allowing for imaging dose reduction. However, there are a few practical concerns preventing the clinical implementation of these techniques. On the image quality side, data truncation along the superior-inferior direction under the cone-beam geometry produces severe cone artifacts in the reconstructed images. Ring artifacts are also seen in the half-fan scan mode. On the reconstruction efficiency side, the long computation time hinders clinical use in image-guided radiation therapy (IGRT). Methods: Image quality improvement methods are proposed to mitigate the cone and ring image artifacts in IR. The basic idea is to use weighting factors in the IR data fidelity term to improve projection data consistency with the reconstructed volume. In order to improve the computational efficiency, a multiple graphics processing units (GPUs)-based ...
From Higgs to the Hospital: Normal Tissue Complication Probability Modeling in Radiation Therapy Eric Williams Memorial Sloan-Kettering Cancer Center New York,…
TY - JOUR. T1 - WE‐G‐BRCD‐01. T2 - A Procedure for Efficient Large‐Scale Retrospective Clinical Studies for Online Adaptive Radiotherapy. AU - Lambrecht, M.. AU - Graves, Y.. AU - Gautier, Q.. AU - Tian, Z.. AU - Kim, G.. AU - Uribe‐sanchez, A.. AU - Jia, X.. AU - Jiang, S.. PY - 2012. Y1 - 2012. N2 - Purpose: Online adaptive radiotherapy (ART) is promising for handling inter‐fraction variations of patients geometry. Before a clinical implementation of this advanced technology, it is necessary to study its potential clinical gains and optimal frequencies to be used for various tumor sites. The goal of this work is to establish and examine a procedure for efficient large‐scale retrospective clinical studies for online ART using a GPU‐based re‐planning platform. Methods: The proposed procedure utilizes an in‐house developed GPU‐based replanning software called SCORE. SCORE starts by applying deformable registration from CT to CBCT and ...
Photon Beam Dose Calculation Algorithms. Kent A. Gifford, Ph.D. Medical Physics III Spring 2010. Dose Computation Algorithms. Correction-based (Ancient!) Convolution (Pinnacle,Eclipse,…) Monte Carlo (Stochastic) Deterministic (Non-stochastic). Photon Source. Standard SSD. Patient...
Materials and methods: Two registration methods based on optical flow estimation have been programmed to run on a graphics programming unit (GPU). One of these methods by Horn & Schunck is tested on a 4DCT thorax data set with 10 phases and 41 landmarks identified per phase. The other method by Cornelius & Kanade is tested on a series of six 3D cone beam CT (CBCT) data sets and a conventional planning CT data set from a head and neck cancer patient. In each of these data sets 6 landmark points have been identified on the cervical vertebrae and the base of skull. Both CBCT to CBCT and CBCT to CT registration is performed. Results: For the 4DCT registration average landmark error was reduced by deformable registration from 3.5 ± 2.0 mm to 1.1 ± 0.6 mm. For CBCT to CBCT registration the average bone landmark error was 1.8 ± 1.0 mm after rigid registration and 1.6 ± 0.8 mm after deformable registration. For CBCT to CT registration errors were 2.2 ± 0.6 mm and 1.8 ± 0.6 mm for ...
PURPOSE Accurate delineation of target volume and normal tissue is critical for intensity modulated radiation therapy (IMRT) use in cervical cancer. Phase III Multicentre Trial of Weekly Induction Chemotherapy Followed by Standard Chemoradiation versus Standard Chemoradiation Alone in Patients With Locally Advanced Cervical Cancer (INTERLACE) radiation therapy quality assurance (RTQA) has highlighted significant interobserver delineation variation. Prescriptive guidelines reduce interobserver variation in other cancers. METHODS AND MATERIALS A literature search using PubMed/Medline database of guidelines for target anatomy delineation in cervical cancer was undertaken. Differences in practice in these publications and INTERLACE trial RTQA were identified. Consensus best practice delineation was derived and a pictorial atlas produced. The proportion of outlines complying with protocol in test and real-time cases was compared before and ...
MODEL RELEASED. Prostate cancer radiotherapy surgery. Surgeon inserting radioactive sources into a patients prostate gland. The radioactive sources are being implanted using needles inserted through a template (black square), through the perineal skin, and then guided to the prostate gland using a trans-rectal ultrasound probe. This implantation of radioactive sources is a procedure known as brachytherapy, a form of radiotherapy. The radiation from the radioactive sources kills the cancerous cells. The syringe (lower right) is used to inflate the silicon sheath around the probe with water. This improves the quality of the ultrasound picture. - Stock Image C001/8059
MODEL RELEASED. Prostate cancer radiotherapy surgery. Surgeon inserting radioactive sources into a patients prostate gland. The radioactive sources are being implanted using needles inserted through a template (black square), through the perineal skin, and then guided to the prostate gland using a trans-rectal ultrasound probe. This implantation of radioactive sources is a procedure known as brachytherapy, a form of radiotherapy. The radiation from the radioactive sources kills the cancerous cells. - Stock Image C001/8061
Discover how UPMC Whitfield Cancer Center uses image-guided radiation therapy to minimize radiation exposure to healthy tissue surrounding a tumor.
Radiation Oncologists and Radiation Oncology Residents. Radiation oncologists are the doctors who will oversee your radiation therapy treatments. Radiation Oncologist Residents are the doctors who have finished their internal medicine internship and are in training to be radiation oncologists and assisting radiation oncologists to provide care to the cancer patients. These physicians work with the other members of the radiation therapy team to develop your treatment plan and ensure that each treatment is given accurately. Your radiation oncologist will also monitor your progress and adjust the treatment as necessary to make sure the radiation is hitting its target while minimizing side effects. Before, during and after your radiation therapy treatments, your radiation oncologist works closely with other cancer doctors, such as medical oncologists and surgeons, to maximize the radiations effectiveness. Radiation oncologists have completed at least four years of college, four ...
In the current study, we assessed the conventional BRT plan based on ICRU reference points and the CT-based BRT plan in patients with cervical cancer. We clearly demonstrated that tumor volume coverage was inadequate in the conventional plan compared to the CT-plan, and was inversely related with the volume of the target and the extension of tumor. With the conventional plan, the ICRU rectum and bladder point doses underestimated the actual rectum and bladder doses obtained from the CT-plan. Additionally, we demonstrated that more precise analysis of the dose received by certain volume of OARs can be accomplished by utilizing the DVHs on CT-plans, which may be of critical importance in regard to normal tissue tolerance limits.. After publication of ICRU 38 report, ICRU reference points for tumors, and reference dose points for bladder and rectum were used for defining the doses in conventional plans. But calculation of doses with these fixed reference points relative to applicators has ...
The Helical Tomotherapy treatment planning system uses a relatively accurate collapsed cone convolution/superposition algorithm for dose calculation and, as with other non -Monte Carlo algorithms, charged particle equilibrium is assumed in the dose calculation. For this reason we can expect inaccuracy in predicting dose distribution in the presence of significant inhomogeneities in patient geometry where this assumption is not satisfied. The dose distribution accuracy of the HT TPS was then tested in case of low density lung lesions.. Before the validation of the dose calculation algorithm in inhomogeneous media, the agreement between measured and calculated dose distributions for lung treatments was verified in a homogeneous phantom. Excellent agreement was found for point dose measurements with most of the data within ± 2%; an average percentage discrepancy equal to 0.85% (1SD = 0.5%) was estimated by considering all the points, both in PTV and in OAR regions. Good agreement (3%- 3 mm ...
Purpose: Dose volume histograms (DVHs) are common tools in radiation therapy treatment planning to characterize plan quality. As statistical metrics, DVHs provide a compact summary of the underlying plan at the cost of losing spatial information: the same or similar dose-volume histograms can arise from substantially different spatial dose maps. This is exactly the reason why physicians and physicists scrutinize dose maps even after they satisfy all DVH endpoints numerically. However, up to this point, little has been done to control spatial phenomena, such as the spatial distribution of hot spots, which has significant clinical implications. To this end, the authors propose a novel objective function that enables a more direct tradeoff between target coverage, organ-sparing, and planning target volume (PTV) homogeneity, and presents our findings from four prostate cases, a pancreas case, and a head-and-neck case to illustrate the advantages and general ...
During external beam radiation therapy, a beam (or multiple beams) of radiation is directed through the skin to the cancer and the immediate surrounding area to destroy the tumor and any nearby cancer cells.
The department includes treatment, physics, dosimetry and planning facilities, a 10 examination room outpatient clinic with procedure room, 2 additional consultation rooms, office space, a departmental library with computer terminal internet access, and two conference rooms of 20 and 50 person capacity. Conference space is equipped with audio visual links to other centers, as well as secure online computer access to dosimetry, diagnostic radiology, radiotherapy based imaging, and internet. Multiple treatment planning systems are available, and MR and PET data/image merge, in conjunction with CT simulation, is available for treatment planning. Major items of equipment include a Varian Trilogy™ linear accelerator with multiple photon and electron energies, stereotactic body radiosurgery (SBRT), gating capability, and image guided radiotherapy (IGRT/IMRT/MLC). The department also has a ...
This NCAT guidance, developed by professionals from SCoR,RCR, IPEM and HPA, should be read inconjunction with On Target: Ensuring Geometric Accuracy (joint SCOR, IPEM, RCR publication 2008) which is also available on the policy and guidance document library. The NRAG report, published in 2007, sets out the important role of 4D adaptive radiotherapy (4D-ART), and advanced radiotherapy should become the standard of care. This guidance is written to support the wider adoption and application of Image guided radiotherapy (IGRT) to enable the future implementation of 4D adaptive radiotherapy throughout England. This guidance is designed for radiotherapy professionals of all disciplines in the implementation, choice and use of appropriate IGRT techniques to ensure high quality standards across England.. ...
The department of Radiotherapy was granted Regional Cancer Centre status by the Ministry in 2002. An Oncology ward was established in 2006. The MoHFW, Government of India, has subsequently accorded sanction for construction of a separate RCC building. Accordingly a separate block for Regional Cancer Centre with a capacity for 82 inpatient beds (including 20 special ward beds), outpatient facilities, day care centre, ICU, etc has been constructed. The RCC building, with wards and OPD blocks, was inaugurated on 23.01.2008.. In 2008, JIPMER was made an Institution of National Importance under an Act of Parliament (JIPMER Puducherry Act, 2008) and charged with responsibilities to develop teaching in under-graduate and postgraduate medical education in all branches. All cancer treatments including high precision Intensity modulated and Image Guided Radiotherapy as well as latest chemotherapy are given free-of-charge to poor ...
The Radiation Oncology Marketplace is the database dedicated to radiation oncology professionals, helping them find the products & services they need. Alliance Oncology - Alliance Oncology partners with hospitals, physicians, and other healthcare providers to set a new standard of care for cancer patients. This is achieved through the establishment of state-of-the-art cancer centers or the enhancement of existing facilities with advanced technologies, including Intensity Modulated Radiation Therapy (IMRT), Image Guided Radiation Therapy (IGRT), and Stereotactic Radiosurgery (SRS).
The Radiation Oncology Marketplace is the database dedicated to radiation oncology professionals, helping them find the products & services they need. Alliance Oncology - Alliance Oncology partners with hospitals, physicians, and other healthcare providers to set a new standard of care for cancer patients. This is achieved through the establishment of state-of-the-art cancer centers or the enhancement of existing facilities with advanced technologies, including Intensity Modulated Radiation Therapy (IMRT), Image Guided Radiation Therapy (IGRT), and Stereotactic Radiosurgery (SRS).
This service provides Intensity Modulated Radiation Therapy (IMRT), Image Guided Radiation Therapy (IGRT), Stereotactic Radiosurgery (SRS), and Stereotactic Body Radiation Therapy (SBRT). Our dedicated team includes specialists in pediatric sedation and anesthesia. The Hospital has been recognized for pediatric cancer management and has received approval for installation of a Proton Therapy machine, expected to come on line in 2016 for treatment of children. Appointment line: 202-444-9328. Appointment hours: Monday - Friday, 8 a.m. - 5 p.m.. ...
CRAWLEY, U.K., April 29, 2013 /PRNewswire/ -- Hospitals in London and Dorset have acquired the final two of ten advanced Varian Medical Systems (NYSE: VAR [1]) radiotherapy treatment machines offered as part of an innovative government program to roll out the most modern cancer treatments for patients in the UKs public hospitals. North Middlesex University Hospital and Poole Hospital NHS Foundation Trust have ordered TrueBeam™ medical linear accelerators via an NHS Supply Chain initiative aimed at stimulating replacements of older treatment machines with state-of-the-art systems.. For North Middlesex University Hospital, the TrueBeam ordered earlier this year replaces an older radiotherapy machine and will enable the hospital to introduce advanced radiotherapy techniques such as image-guided radiotherapy (IGRT), stereotactic body radiotherapy (SBRT) and stereotactic radiosurgery (SRS) for the first time, ...
Also, the research study gives a complete list of all the leading players working in the Global Image Guided Surgery Devices market. Moreover, the financial status, company profiles, business strategies and policies, and the latest expansions in the Global Image Guided Surgery Devices market have been mentioned in the research study.. For more inquiry before purchase: https://www.researchnreports.com/enquiry_before_buying.php?id=49915. Table of Contents. 1 Industry Overview of Image Guided Surgery Devices. 2 Manufacturing Cost Structure Analysis of Image Guided Surgery Devices. 3 Technical Data and Manufacturing Plants Analysis of Image Guided Surgery Devices. 4 Global Image Guided Surgery Devices Overall Market Overview. 5 Image Guided Surgery Devices Regional Market Analysis. 6 Global 2011-2016E Image Guided Surgery Devices Segment Market Analysis (by Type). 7 Global 2011-2016E Image Guided Surgery Devices Segment Market Analysis (by Application). 8 Major Manufacturers Analysis of Image Guided ...
This randomized phase II trial studies how well positron emission tomography (PET)/computed tomography (CT)-guided radiation therapy works compared to standard radiation therapy in treating patients with stage III non-small cell lung cancer. Radiation therapy uses high-energy x-rays to kill tumor cells. Using imaging procedures, such as PET and CT scans, to guide the radiation therapy, may help doctors deliver higher doses directly to the tumor and cause less damage to healthy tissue ...
Unlike other radiation modalities such as IMRT, IGRT and proton beam, prostate brachytherapy is immune to prostate motion.. There are many different technologies to treat prostate cancer with radiation, such as Intensity-Modulated Radiation Therapy (IMRT), Image-Guided Radiation Therapy (IGRT), and proton beam therapy. These are all technologies that have been developed to promote and deliver the concept of dose escalation to the prostate; which means the more radiation you give to the prostate, the more likely you are to cure the cancer. However, there are adjacent structures to the prostate, which include the bladder and the rectum, and ideally, these structures should not receive any radiation. Thus, this limits the amount of radiation that can be delivered safely from the actual source. People have gone to great effort in order to account for prostate ...
Renal cell carcinoma (RCC) is traditionally considered to be radioresistant; therefore, conventional radiotherapy (RT) fraction sizes of 1.8 to 2 Gy are thought to have little role in the management of primary RCC, especially for curative disease. In the setting of metastatic RCC, conventionally fractionated RT has been an effective palliative treatment in 50% of patients. Recent technological advances in radiation oncology have led to the clinical implementation of image-guided radiotherapy, allowing biologically potent doses to the tumors intra- and extra-cranially. As predicted by radiobiologic modeling, favorable outcomes have been observed with highly hypofractionated schemes modeled after the experience with intracranial stereotactic radiosurgery (SRS) for RCC brain metastases with reported local control rates averaging 85%. At present, both primary and metastatic RCC tumors may be successfully treated using stereotactic approaches, which utilize steep dose gradients ...
The next step will be to test the method (termed BIS-IGRT, Biological In-Situ enhanced IGRT) in animal models. A series of drug-loaded devices is under development for this purpose, in collaboration with nanotechnology and nanomedicine experts at Northeastern University, in order to look at the tumor-sensitizing properties of the implants. Source: ...
General radiation oncology with expertise in stereotactic radiosurgery/radiotherapy, image-guided radiotherapy, and intensity modulated and 3D conformal radiotherapy.. Education ...
Journal Name: Medical Physics; Journal Volume: 41; Journal Issue: 8; Other Information: (c) 2014 American Association of Physicists in Medicine; Country of input: International Atomic Energy Agency (IAEA ...
Introduction: Diagnosis and Therapy - History, Current Status and Future Direction. Imaging Modalities - Body Imaging. Ultrasound. MRI. CT. Optics. PET/SPECT. Advanced Cardiac Imaging. Interventional Therapy Modalities - Cut and Paste: Scalpels and Sutures. Minimally-Invasive Surgery. X-Rays and Radiation. Radio Frequency Ablation. Microwave Ablation. Laser. Cryotherapy. Gamma Knife. Drug Delivery and Thrombolysis. Hyperthermia. Image-Guided Therapy - Percutaneous Aspirations, Biopsies and Nerve Blocks. Enoscopic, Catheterization and Biopsy Procedures. 3D Visualization, Stereotactic Methods, and Neurosurgery. Automation and Robotics. Modeling of Image-Guided Therapy. High-Intensity Focused Ultrasound. Practical Considerations of Image-Guided Therapy - Clinical Perspectives on Image-Guided Therapy. Real Market of Image-Guided Therapy.; To view complete TOC:; Click Google Preview button under book title above, then click on Contents tab.; ...
TY - JOUR. T1 - Stereotactic body radiotherapy (SBRT) for oligometastatic lung tumors from colorectal cancer and other primary cancers in comparison with primary lung cancer. AU - Takeda, Atsuya. AU - Kunieda, Etsuo. AU - Ohashi, Toshio. AU - Aoki, Yousuke. AU - Koike, Naoyoshi. AU - Takeda, Toshiaki. PY - 2011/11. Y1 - 2011/11. N2 - Purpose: To analyze local control of oligometastatic lung tumors (OLTs) compared with that of primary lung cancer after stereotactic body radiotherapy (SBRT). Materials and methods: Retrospective record review of patients with OLTs who received SBRT with 50 Gy in 5 fractions. Local control rates (LCRs), toxicities, and factors of prognostic significance were assessed. Results: Twenty-one colorectal OLTs, 23 OLTs from other origins, and 188 primary lung cancers were included. Multivariate analysis revealed only tumor origin was prognostically significant (p , ...
Toxic risk of stereotactic body radiotherapy and concurrent helical tomotherapy followed by erlotinib for non-small-cell lung cancer treatment - case report. . Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.
OBJECTIVES: To review the use of fiducial markers and spacers in prostate radiotherapy (RT). MATERIALS AND METHODS: We reviewed the literature on the use of fiducial markers to improve accuracy in delivery of RT for prostate cancer. We discuss the rationale for fiducials, the types available, the procedures and complications. We also reviewed the current literature on the novel use of spacers to reduce rectal toxicity during prostate irradiation. RESULTS: Prostate motion is a significant problem both during and between RT treatments. Intraprostatic fiducials allow accurate prostate localisation ensuring RT treatment accuracy. Insertion of gold fiducials are a cost-effective marker that can be easily and quickly implanted and at least three fiducials are recommended. Severe complications from fiducial implantation are uncommon and marker migration is very rarely clinically significant. ...
293535305 - EP 1100473 A2 2001-05-23 - ABSORBABLE BRACHYTHERAPY AND CHEMOTHERAPY DELIVERY DEVICES AND METHODS - [origin: WO0006243A2] Combination radiation delivery and chemotherapy devices comprise bioabsorbable structures with radionuclides and chemotherapeutic agents immobilized on said structures. The bioabsorbable structures have a predefined persistence period which is usually substantially greater then the half-life of the radionuclide, thus assuring that the radionuclides remain localized and sequestered at a desired target site while significant radioactivity remains. The radiation delivery and chemotherapy devices are suitable for a wide variety of medial purposes, being particularly suitable for the treatment of solid tumors by injection or open surgical introduction of the devices at a target site. Kits comprising the devices together with instructions for use are also provided.[origin: WO0006243A2] Combination radiation delivery and chemotherapy devices comprise bioabsorbable structures
The CyberKnife technology utilises a robotic arm to deliver high doses of radiation that are generated from a miniature linear accelerator. A proprietary image-guidance system allows real time target tracking in order to compensate for natural tumour movement due to respiration, resulting in superior accuracy in radiation delivery. Dr. Richard Whyte, M.D., Associate Professor and Head of the Division of Thoracic Surgery at Stanford University Medical Center, stated: "The CyberKnife provides a unique treatment option for certain lung tumours. The early results of single fraction radio-surgery look quite encouraging.". Dr. Richard Crownover, M.D., Ph.D., Radiation Oncologist at the Cleveland Clinic Foundation and Principal Investigator of the CCF lung protocol, noted: "In the past, lung movement hampered conventional radiation delivery. New modifications enable the CyberKnife to track tumour motion so that a higher dose of radiation can be administered to the patient with minimal toxicity to ...
Radiation recall phenomenon is an inflammatory process occurring at sites of previous radiation subsequent to administration of pharmacologic agents. The most common chemotherapeutic agents implicated with radiation recall phenomenon are anthracyclines and taxanes. Skin is the most common site for radiation recall. About 63% of the radiation recall events are reported to manifest as dermatitis. This finding differs from radiation recall due to Gemcitabine, in which approximately 70% cases manifested as inflammation of internal organs or tissues and 30% manifested as dermatitis. Here, we report a case of post-operative peri-ampullary carcinoma who developed radiation recall dermatitis during adjuvant chemotherapy with inj. Gemcitabine and inj. Carboplatin after concurrent chemoradiation with capecitabine. ...
Health, ...Image guided drainage of tubo ovarian abscesses help women avoid surge...The study included 54 TOAs in 46 patients. Results showed that image ... Image guided drainage should be considered as an alternative to salpi... The procedure is quite safe. The complication rate in our series of i...,Image-guided,treatment,helping,women,with,tubo-ovarian,abscesses,avoid,unnecessary,surgery,medicine,medical news today,latest medical news,medical newsletters,current medical news,latest medicine news
Ali Fatemi, PhD, MCCPM Chief Physicist, Division of Medical Physics, Department of Radiology Director of MR guided Radiotherapy lab Senior and Assistant Professor, Departments of Radiology and Radiation Oncology(601) 815-1778Lab websiteJudd Storr, PhD MRI Physicist, Division of Medical Physics, Department of Radiology Assistant Professor, Department of RadiologyEdward Florez, PhD Researcher I, Division of Medical Physics, Department of RadiologyCharles S. Adcock, BSc Research Assistant, Medical Student Department of Radiology Project: Quantitative Magnetic Resonance Imaging for response assessment of liver metastases to Y90 brachytherapyJoseph D. Saucier, BSc Research Assistant, Medical Student Department of Radiology Project 1 - Magnetic Resonance Imaging (MRI-guided CNS radiotherapy
Expertise, Disease and Conditions: Adrenal Cancer, Bladder Cancer, Image-Guided Radiation Therapy, Intensity-Modulated Radiation Therapy (IMRT), Metastatic Bone Disease, Metastatic Disease, Oligometastatic Disease, Penile Cancer, Prostate Cancer, Radiation Oncology, Stereotactic Body Radiation Therapy, Testicular Cancer, Urethral ...
Radiation therapy is the use of ionizing radiation for treatment of diseases and the specialized field of using ionizing radiation for the treatment of cancers is known as Radiation Oncology Approximately. 2/3rd of all cancer patients require radiation therapy as the sole treatment modality or in combination with surgery or anticancer drugs (Chemotherapy). Radiotherapy plays a very important role in curing early stage cancer and in relieving symptoms and possibly prolonging life for patients with advanced cancers. Our efforts in the department will be to offer optimal radiotherapy and comprehensive patient care. Optimal & efficient delivery of treatment not only requires the appropriate infrastructure but also well trained and motivated personnel. The will facilities offer modern sophisticated, state-of-the-art treatments like 3-D conformal radiotherapy (3-D CRT), intensity ...
BACKGROUND: Corticosteroid injections can be performed blind (landmark-guided) or with image guidance, and this may account for variable clinical outcomes. The objective of this study was to assess the effectiveness and safety of image-guided versus blind corticosteroid injections in improving pain and function among adults with shoulder pain.. METHODS: MEDLINE, the Cochrane Controlled Trials Register and EMBASE were searched to May 2010. Additional studies were identified by searching bibliographies of shortlisted articles. Search items included blind, landmark, anatomical, clinical exam, image-guided, ultrasound, fluoroscopy, steroid injection, frozen shoulder, random allocation, randomized controlled trial (RCT) and clinical trial.Randomized controlled studies comparing image-guided versus blind (landmark-guided) corticosteroid shoulder injections that examined pain, function and/or adverse events were included. Independent extraction was done by two authors using a form with pre-specified ...
Dose distribution of stereotactic body radiotherapy (SBRT) for a tumor in superior (A, B) and in inferior lobe (E, F). Prescribed doses were both 48 Gy in four
Give your patients the non-surgical pain relief they need with help from the Atlas of Image-Guided Spinal Procedures. This medical reference book features a highly visual format that shows you exactly how to perform each technique to get the best results.. Give your patients the pain relief they need with the latest image-guided spinal injection procedures! A highly visual format shows you exactly how to perform each technique.. • Safely and efficiently relieve your patients pain thanks to an atlas format that displays each procedure step-by-step.. • See properly performed injections for yourself with an algorithmic,image-guided approach for each technique: trajectory view (demonstrates fluoroscopic "set up"); multi-planar confi rmation views (AP, lateral, oblique); and "safety view" (what should be avoided during injection), along with optimal and suboptimal contrast patterns.. • Special chapters on Needle Techniques, Fluoroscopic Imaging Pearls, Radiation Safety, and L5-S1 Disc Access ...
Stereotactic Body Radiotherapy (SBRT) is increasingly used to treat a variety of head and neck tumors as a result of its highly conformal dose distributions and stereotactic spatial accuracy in delivery. Our experience and other previous reports have shown that SBRT is technically feasible, well-tolerated and compares favorably to other alternatives of salvage therapy in the management of patients with recurrent and/or previously irradiated head and neck cancers. Furthermore, it has the advantage of a shorter treatment schedule, greater compliance, and safe delivery in the outpatient setting. This affords an opportunity to introduce SBRT as a definitive treatment in select patients. This review presents an overview of the use of SBRT for managing head and neck tumors by highlighting the existing indications and the expanding role of SBRT in managing these patients.
Nearly 50% of cancer patients undergo radiotherapy. Late radiotherapy toxicity affects quality-of-life in long-term cancer survivors and risk of side-effects in a minority limits doses prescribed to the majority of patients. Development of a test predicting risk of toxicity could benefit many cancer patients. We aimed to meta-analyze individual level data from four genome-wide association studies from prostate cancer radiotherapy cohorts including 1564 men to identify genetic markers of toxicity. Prospectively assessed two-year toxicity endpoints (urinary frequency, decreased urine stream, rectal bleeding, overall toxicity) and single nucleotide polymorphism (SNP) associations were tested using multivariable regression, adjusting for clinical and patient-related risk factors. A fixed-effects meta-analysis identified two SNPs: rs17599026 on 5q31.2 with urinary frequency (odds ...
Dr. Footes research interests include treatment of malignant and benign tumors of the head and neck region (including endocrine neoplasms such as thyroid and parathyroid cancer) and skin.. This includes evaluating new radiation fractionation schemes, combining radiation therapy with chemotherapy, immunotherapy, and targeted biological agents; and evaluating new technology such as volumetric modulated radiation therapy, stereotactic radiosurgery, intensity modulated radiation therapy, 4-dimensional radiation simulation and treatment, adaptive radiation therapy, image-guided radiation therapy and proton/heavy ion beam therapy.. Dr. Foote also has research interests in the prevention and management of acute and chronic effects of radiation such as, mucositis, xerostomia and carotid artery stenosis. Much of his research has been conducted in collaboration with the Mayo Clinic Cancer Center, North Central Cancer Treatment Group and the Radiation Therapy Oncology ...
http://www.DiabloValleyOncology.md We provide comprehensive and high quality oncology, hematology and urologic care by utilizing the latest technology, therapies, techniques and clinical trials. Our Services: -Medical Oncology (Chemotherapy, Immunotherapy, Hormonal Therapy, Experimental Therapy) -Radiation Oncology (Image-guided radiation therapy, Intensity modulated radiation therapy, Three-dimensional conformal radiation therapy, Stereotactic radiosurgery, Electronic Brachytherapy, Calypso-GPS system) -Hematology (Blood cancer and blood disorder care) -Urology (kidney stones, impotence, female and male incontinence, prostate challenges, vasectomy and reversals, specialized surgeries and infertility treatment) -Clinical Trials and Research -MRI/PET/CT Diagnostic Imaging -Laboratory Services -Pharmacy Services -Chemo and Nutrition Counseling -Infusion Services -Oncology Rehabilitation -Patient Supportive Services. ...
The utility of positron emission tomography/computed tomography in target delineation for stereotactic body radiotherapy for liver metastasis from primary gastric cancer: an illustrative case report and literature review
PURPOSE The purpose of this study was to characterize treatment-related toxicities, health-related quality of life (HRQOL), and biochemical outcomes in patients treated with postoperative image guided intensity modulated radiation therapy (IMRT) for prostate cancer using a consensus guideline for defining the clinical target volume. METHODS AND MATERIALS Between August 2007 and October 2008, patients considered for radiation therapy (RT) after prostatectomy were enrolled. The clinical target volume (prostate bed) was delineated according to published consensus guidelines, and patients were prescribed a dose of 66 Gy in 33 fractions. Radiation treatment planning prioritized rectal dose constraints over target volume coverage. Treatment was delivered by use of IMRT and daily cone beam computed tomographic guidance. Toxicity (graded according to the National Cancer Institutes Common Terminology Criteria for ...
Read "Global rigid registration of CT to video in laparoscopic liver surgery, International Journal of Computer Assisted Radiology and Surgery" on DeepDyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips.
In this paper, we propose a robust 3D rigid registration technique for detecting cerebral aneurysms, arterial stenosis, and other vascular anomalies in a brain CT angiography. Our method is composed o
Optimal radiation for gynecologic malignancies often combines both teletherapy (external beam radiotherapy) and brachytherapy (internal radiation) with careful clinical judgment required to determine the proper weighting of each component. The challenge in radiation delivery is to deliver intended full dose(s) to selected target(s), while minimizing exposure to adjacent normal tissues. Sophisticated developments in imaging, computer-based treatment planning, and linear accelerator technology provide for ever-greater sophistication and accuracy in radiotherapy. However, such precision in dose delivery has to be accompanied by improvements in patient set-up immobilization, reproducibility, and regular tumor tracking to prevent marginal misses of the intended target volume. Advances in radiotherapy for gynecologic malignancies will be based on further integration with systemic agents (for both spatial cooperation and ...
Purpose: To evaluate the variability in heart position in deep-inspiration breath-hold (DIBH) radiotherapy for breast cancer when 3D surface imaging would be used for monitoring the depth of the breath hold during treatment. Materials and Methods: Ten patients who received DIBH radiotherapy after breast-conserving surgery (BCS) were included. Retrospectively, heart-based registrations were performed for cone-beam computed tomography (CBCT) to planning CT and breast surface registrations were performed for a 3D surface (two different regions of interest [ROIs]), captured concurrently with CBCT, to planning CT. The resulting setup errors were compared with linear regression analysis and receiver operating characteristic (ROC) analysis was performed to investigate the prediction quality of 3D surface imaging for 3D heart displacement. Further, the residual setup errors (systematic [Σ] and random [σ]) of the heart were estimated ...
The 3rd Annual Meeting of the EAU Section of Urological Imaging (ESUI) in Lisbon, Portugal in November this year will present image-guided therapies for prostate and kidney cancers, complementing the comprehensive scientific programme of the 6th European Multidisciplinary Meeting on Urological Cancers (EMUC).. "The ESUI programme will cover in detail the hottest topics in imaging. We will especially address imaging and image-guided therapies, such as focal therapy, for the prostate and small renal masses," said ESUI chairman Dr. Jochen Walz (Marseille, FR). "Other aspects of interventional and intraoperative imaging are also important topics. We will also examine the role of PET-CT in managing urological malignancies in a joint meeting with the European Association of Nuclear Medicine (EANM).". The ESUIs meeting on November 13 will precede the 6th EMUC. From November 14 to 16. EMUC will hold 21 sessions in a compact scientific programme that ...
Proven efficiency of IGS and RAS drives volume adoption in cardiac, orthopedic and neurological procedures KUALA LUMPUR, Malaysia, Feb. 11, 2014 /PRNewswire/ -- Asia-Pacific is a hotbed of investment activity owing to the booming economic growth in its emerging countries. The markets vibrancy has particularly aided the healthcare industry, where private hospitals are looking to make the most of these trends by investing in assistive technologies. Higher disposable incomes, deeper penetration of health insurance, and improvement in the overall quality of life have created a huge demand for quality healthcare services. Therefore, there is rising interest in efficient and patient-safety treatment protocols that can be achieved using image-guided surgery (IGS) and robot-assisted surgery (RAS).. New analysis from Frost & Sullivan (http://www.medtech.frost.com), Image-guided and Robot-assisted Surgery Market in Asia-Pacific, finds that the market earned revenues of US$217.4 ...
May 21, 2008 - Aarhus University Hospital of Aarhus, Denmark, placed an order for three new treatment machines and nine advanced RapidArc volumetric arc therapy systems, planning to have RapidArc installed on all nine of its Clinac linear accelerators later this year, in hopes of consolidating all radiotherapy hardware and software in an integrated system.. Two of the additional treatment machines will be installed at a new radiotherapy center being constructed alongside the general hospital in the town of Herning, which is sixty miles from Aarhus but will effectively be a part of the Aarhus campus.. RapidArc radiotherapy technology is designed to deliver image-guided, intensity-modulated radiation therapy (IMRT) reportedly two to eight times faster and more precisely than conventional IMRT or helical tomotherapy.. RapidArcs volumetric modulated arc therapy delivers a complete IMRT treatment in a single rotation of the treatment machine ...
In this work, a comparative analysis of optical (OTS) and electromagnetic (EM) tracking systems for monitoring respiratory motion in image-guided proton therapy has been reported. This has covered both the technical and clinical aspects of integrating such tracking technologies into the treatment process for 4D treatments on a PBS proton gantry.. A wide range of solutions for non-invasive monitoring are currently available, such as the Varian Real-time Position Management (RPM, Varian Medical Systems Inc., Salt Lake City, US) and the Anzai Respiratory Gating System (AZ-733 V, Anzai Medical Co., Ltd, Tokyo, Japan) to name the two most popular systems used for radiotherapy [31, 32]. Despite the use of calibration procedures however, it is often difficult to relate the load variation of the Anzai belt, or the laser sensor measurement, to the geometrical patient displacement in anatomical coordinates, making these solutions best suited for the detection of intra-fraction relative motions. ...
June 22, 2012 - MD Anderson Cancer Center Orlando announced it has installed the first Accuray TomoHD system in Florida.. Unlike traditional radiation therapy devices, the TomoHD system combines fully integrated computed tomography (CT) imaging and intensity-modulated radiation therapy (IMRT) on a CT scanner platform. Each daily treatment includes a 3-D image of the patients anatomy to ensure highly accurate radiation delivery. This provides clinicians unprecedented confidence that tumors will receive their intended dosage from one day to the next.. A major difference with the TomoHD system is the way that radiation is delivered to the treatment area. The radiation beam is divided into thousands of tiny "beamlets" all aiming at the tumor during multiple 360-degree rotations around the patient. The treatment dose conforms to the tumor and avoids critical organs, which can mean improved outcomes, fewer side effects and a higher quality of life for the patient.. "We have continually been a ...
The staff at Urology Specialists, PC are excited to announce our plan to partner with our urologic colleagues in the region who currently comprise KCUC, Kansas City Urology Care, PA.This would allow for unparalleled collaboration with other single specialty physicians in the field to continue to offer advanced care and services, but also to allow access to new research and clinical trials as well as new technology such as RapidArc radiotherapy used to treat prostate cancer. RapidArc is a new approach to delivering image-guided, intensity-modulated radiation therapy (IG-IMRT). This improves tumor targeting and shapes the radiation dose so more radiation is delivered to the tumor and less to surrounding healthy tissues.. As we move forward, our transition period for this integration begins in July 2014 and likely will take 6-12 months. We want to assure you that at no time will this reorganization negatively impact your care or access to the doctor you see ...
In point-based rigid-body registration, target registration error (TRE) is an important measure of the accuracy of the performed registration. The registrations accuracy depends on the fiducial localization error (FLE) which, in turn, is due to the
Interfraction prostate motion must be compensated by increased safety margins. If filling status of rectum and bladder is constant, motion should be reduced. We attempted to reduce interfraction motion errors by proper patient instruction. In 3
6th Annual World Congress for Brain Mapping and Image Guided Therapy Annual Congress of the International Brain Mapping and Intraoperative Surgical Planning Society - IBMISPS 26-29 August 2009 Harvard Medical School, Boston, USA CALL FOR PAPERS - Abstract Submission Deadline: 27 March 2009 www.ibmisps-worldcongress.org The Board of Directors of the International Brain Mapping Foundation invites you to become a member or sponsor of a CME credited multidisciplinary clinical and basic science research forum. The congress program will consist of invited keynote lectures and presentations selected from submitted abstracts for which contributions are now invited. Coverage will range from basic translational research and multidisciplinary clinical practice and surgery to healthcare policy and neuroeconomics, including: - Brain mapping - Image guided therapy/surgery - Healthcare policy - FDA regulations - Bioethics and neuroeconomics - Biomedical, chemical and materials engineering - Neuroscience - ...
The article by Drs. Merrick, Wallner, and Butler provides an excellent overview of issues pertaining to sexual dysfunction following prostate brachytherapy. The authors were the first to address the historical and current problems with diagnosing sexual dysfunction. They make a strong case for developing a quality-of-life (QOL) instrument that is specific for prostate brachytherapy. 1
A system adapted to control the operation of a fine needle aspiration (FNA) biopsy device provided with a syringe to which is transferred a tissue sample extracted from an internal target in the body of a patient in which the needle is injected. Associated with this biopsy device is an ultrasound imaging instrument having a transducer placed on a body site overlying the internal target and coupled to a CRT monitor. The needle is injected into the patient through a guide passage in the transducer, hence displayed on the CRT screen is an image of the internal target and that of the advancing needle. The biopsy device is controlled by a pneumatic or motor-driven mechanism operatively coupled to a guide tube through which the needle extends, For a first phase of an operating cycle, the mechanism advances the needle toward the target to extract a tissue sample therefrom. In a second operating phase, the mechanism acts to retract the tissue loaded needle from the body of the patient. And in the final
This study is the first to show that platelet activation is increased by the brachytherapy currently applied in clinical practice. A notable increase was found after brachytherapy compared with PCI without irradiation. We have previously identified increased platelet activation after conventional PCI as an independent risk factor for acute ischaemic events.20 The data on radiation delivery devices submitted for US Food and Drug Administration (FDA) approval showed that patients treated with radiation benefit from a reduction in recurrent stenosis but also have the disadvantage of an increased rate of thrombotic events.192324 Thrombotic occlusions are associated with increased mortality after PCI21 and an increased risk of myocardial infarctions after VBT.1419232526 The increase in platelet activation after brachytherapy is not suppressed by concomitant treatment with aspirin and clopidogrel. Both drugs were given to all 23 patients three to four weeks before elective brachytherapy. In the group ...
Looking for megavoltage? Find out information about megavoltage. A unit of potential difference or emf , equal to 1,000,000 volts. Abbreviated MV Explanation of megavoltage
As a Texas medical doctor and DePuy ASR recall and DePuy Pinnacle injury replacement attorney I am providing this litigation update. The DePuy Pinnacle met - September 17, 2012 - DePuy Pinnacle Lawsuits Over Metal Hip Replacements
Health,(PRWEB) November 29 2013 DePuy Pinnacle hip implant lawsuits are progressing in a consolidation of cases in federal court in Texas according to court documents. The Rottenstein Law Group LLP which maintains the Pinnacle informational website http://www.metalhiplaws,DePuy,Settlement,Update:,DePuy,Pinnacle,Lawsuits,Progress,in,Federal,Court,,Rottenstein,Law,Group,LLP,Reports,medicine,medical news today,latest medical news,medical newsletters,current medical news,latest medicine news
Multileaf collimators are offered as an accessory to many accelerators for conformal radiotherapy and the dose planning systems are capable of calculating multileaf collimated beams. There is further a frequent desire to verify the radiation fields on a radiotherapy simulator prior to the actual treatment. For this purpose,an accessory to the simulator was developed (the multileaf delineator). With this unit the front end of the individual leaves are indicated both on the skin of the patient and in the x-ray image. All anatomical structures both outside and inside the field edge are, however, still fully visible.. ...
Percutaneous breast biopsy under imaging guidance (mammography, ultrasound or MRI) is an alternative to open surgical biopsy for the evaluation of indeterminate or suspicious breast lesions. Stereotactic biopsy uses digital mammography along with computer target localization most commonly to biopsy suspicious or indeterminate calcifications in the breast. Occasionally, it can
A challenging case was reported for a patient treated in decubitus position with proton pencil beam scanning. A regular robust plan with the consideration of the uncertainties of translational alignment and range accuracy cannot ensure the target coverage as revealed in two verification computed tomography (CT) scans during the first week of the treatment. The irreproducibility of daily alignment and anatomical variations in such a position is mainly due to patients roll. To mitigate the interfractional effect on the target coverage, a novel robust optimization against the patients angular setup uncertainties was implemented to improve the plan quality by introducing two artificial CT image sets by rolling the planning CT three degrees in both clockwise and counter-clockwise directions and adding them into robust optimization scenarios, which was shown to be an effective and simple way to mitigate target dose degradation with respect to interfractional variations ...
Image-guided surgery (IGS) is the use of a real-time correlation of the operative field to a preoperative imaging data set that reflects the precise location of a selected surgical instrument to the surrounding anatomic structures. Although first developed for neurosurgery, endoscopic sinus surgery (ESS) rapidly became one of the leading indi...
Solaris open-air fluorescence imaging system for image-guided surgery. First large animal imaging system for use with broad spectral range of fluorescent probes.
An integrated radiation therapy process comprises acquiring first objective target data related to a parameter of a target within a patient by periodically locating a marker positioned within the patient using a localization modality. This method continues with obtaining second objective target data related to the parameter of the target by periodically locating the marker. The first objective target data can be acquired in a first area that is apart from a second area which contains a radiation delivery device for producing an ionizing radiation beam for treating the patient. The localization modality can be the same in both the first and second areas. In other embodiments, the first objective target data can be acquired using a first localization modality that uses a first energy type to identify the marker and the second objective target data can be obtained using a second localization modality that uses a second energy.
TY - JOUR. T1 - Resolution enhancement of lung 4D-CT via group-sparsity. AU - Bhavsar, Arnav. AU - Wu, Guorong. AU - Lian, Jun. AU - Shen, Dinggang. PY - 2013/12/1. Y1 - 2013/12/1. N2 - Purpose: 4D-CT typically delivers more accurate information about anatomical structures in the lung, over 3D-CT, due to its ability to capture visual information of the lung motion across different respiratory phases. This helps to better determine the dose during radiation therapy for lung cancer. However, a critical concern with 4D-CT that substantially compromises this advantage is the low superior-inferior resolution due to less number of acquired slices, in order to control the CT radiation dose. To address this limitation, the authors propose an approach to reconstruct missing intermediate slices, so as to improve the superior-inferior resolution. Methods: In this method the authors exploit the observation that sampling information across respiratory phases in 4D-CT can be complimentary due to lung ...
(2015) Jereczek-Fossa et al. Reports of Practical Oncology and Radiotherapy. Objectives: To review the available data about stereotactic body-radiotherapy (SBRT) for oligometastatic lymph node cancer recurrence. Methods: The inclusion criteria for this study were as follows: Medline search for th...
This document describes an ITK-based implementation of intensity-based 2D/3D rigid image registration for patient setup assessment in external beam ra
An improved optical system for treatment of disorders of the skin, especially vascular lesions, such as PortWine Stains. The system irradiates the skin with radiation at a predetermined wavelength and cools the skin during a predetermined time interval in coordination with delivery of the radiation. The absorption of the radiation by the skin and the change in temperature of the skin is monitored by the system and the operation of the radiation delivery system is controlled to optimize treatment of the vascular lesion. The source of irradiation is an arc lamp and the cooling system delivers a cooling gas to a lens in contact with the skin. The cooling gas can be carbon dioxide, freon, or any other appropriate gas. The lens used has a high heat conductivity and may be formed of sapphire.

Robust Contour Propagation Using Deep Learning and Image Registration for Online Adaptive Proton Therapy of Prostate Cancer -...Robust Contour Propagation Using Deep Learning and Image Registration for Online Adaptive Proton Therapy of Prostate Cancer -...

With 80% of the automatically generated treatment plans directly usable without manual correction, a substantial improvement in ... The proposed registration pipeline obtained highly promising results for generating treatment plans adapted to the daily ... Radiotherapy Planning, Computer-Assisted Actions. * Search in PubMed * Search in MeSH * Add to Search ... National Cancer Society . Cancer Stat Facts: Prostate Cancer? https://seer.cancer.gov/statfacts/html/prost.html ...
more infohttps://phgkb.cdc.gov/PHGKB/phgHome.action?action=forward&dbsource=phg&id=34671

John E. Tomaszewski | Faculty | About Us | Perelman School of Medicine | Perelman School of Medicine at the University of...John E. Tomaszewski | Faculty | About Us | Perelman School of Medicine | Perelman School of Medicine at the University of...

Computer-assisted targeted therapy (CATT) for prostate radiotherapy planning by fusion of CT and MRI. SPIE Medical Imaging 7625 ... Evaluation of effects of JPEG2000 compression on a computer-aided detection system for prostate cancer on digitized ... Xu, J., Sparks, R., Janowcyzk,A., Tomaszewski,J.,Feldman, M., Madabhushi, A.: High-Throughput Prostate Cancer Gland detection, ... High-throughput detection of prostate cancer in histological sections using probabilistic pariwise Markov models. Medical Image ...
more infohttp://www.med.upenn.edu/apps/faculty/index.php/g275/p10402

Propagation of target and organ at risk contours in radiotherapy of prostate cancer using deformable image registration.  -...Propagation of target and organ at risk contours in radiotherapy of prostate cancer using deformable image registration. -...

Prostatic Neoplasms/radiotherapy*. *Radiotherapy Planning, Computer-Assisted/methods*. *Radiotherapy, Conformal/methods. * ... Propagation of target and organ at risk contours in radiotherapy of prostate cancer using deformable image registration.. ... The study involved four prostate cancer patients, each with 9-11 repeat CT scans. An oncologist contoured bladder, rectum, ... deformable image registration is an essential component of both dose accumulation and plan adaptation in radiotherapy. The aim ...
more infohttps://www.ncbi.nlm.nih.gov/pubmed/20831491

Technology assessment of automated atlas based segmentation in prostate bed contouring | Radiation Oncology | Full TextTechnology assessment of automated atlas based segmentation in prostate bed contouring | Radiation Oncology | Full Text

Radiotherapy as an adjunct to radical prostatectomy for prostate cancer with adverse features such as pT3 and margin positive ... AABS is a computer-assisted tool that utilizes an algorithm that resamples local data to automatically outline the structures ... Eighty post-prostatectomy patients planned for adjuvant or salvage radiotherapy from January to December 2009 were randomly ... prostate bed radiotherapy is being delivered with intensity modulated radiotherapy (IMRT) and/or image-guided radiotherapy ( ...
more infohttps://ro-journal.biomedcentral.com/articles/10.1186/1748-717X-6-110

Prostate Cancer Imaging. Computer-Aided Diagnosis, Prognosis, and Intervention | Springer for Research & DevelopmentProstate Cancer Imaging. Computer-Aided Diagnosis, Prognosis, and Intervention | Springer for Research & Development

American Cancer Society), and is the most frequently diagnosed cance ... of Organs at Risk from Planning CT for the Development of Voxel-Wise Predictive Models of Toxicity in Prostate Radiotherapy ... HistoCAD: Machine Facilitated Quantitative Histoimaging with Computer Assisted Diagnosis John E. Tomaszewski ... Computer Aided Detection of Prostate Cancer Using T2, DWI and DCE MRI: Methods and Clinical Applications ...
more infohttps://rd.springer.com/book/10.1007%2F978-3-642-15989-3

131I-L19SIP Radioimmunotherapy Combined With Radiochemotherapy in Patients With Locally-advanced Non Small Cell Lung Cancer ...131I-L19SIP Radioimmunotherapy Combined With Radiochemotherapy in Patients With Locally-advanced Non Small Cell Lung Cancer ...

Radiotherapy Planning, Computer-assisted. Computer-assisted mathematical calculations of beam angles, intensities of radiation ... Surgery vs Radiotherapy in the Management of Biopsy Gleason Score 9-10 Prostate Cancer and the Risk of Mortality. ... Cancer Bladder Cancer Brain Cancer Breast Cancer Cancer Cervical Cancer Colorectal Head & Neck Cancers Hodgkin Lymphoma ... Brachytherapy boost after external beam radiotherapy for intermediate and high-risk prostate cancer is presented as an ...
more infohttps://www.bioportfolio.com/resources/trial/64886/131I-L19SIP-Radioimmunotherapy-Combined-With-Radiochemotherapy-in-Patients-With-Locally-advanced-Non.html

PublicationDetailPublicationDetail

... and rectum contours of computer tomography (CT) volumes of 10 patient taken for prostate cancer radiotherapy treatment planning ... Medical Image Computing and Computer Assisted Intervention (MICCAI), London, UK, September 20-24 2009. (bib) ... Chair for Computer Aided Medical Procedures & Augmented Reality. Lehrstuhl für Informatikanwendungen in der Medizin & Augmented ... Nevertheless, in some clinical applications, it is required to compute a smooth deformation field for all the regions within ...
more infohttp://campar.in.tum.de/Chair/PublicationDetail?pub=khamene2009novel

Publications | Center for Computational Imaging and Personalized DiagnosticsPublications | Center for Computational Imaging and Personalized Diagnostics

Computer-assisted targeted therapy (CATT) for prostate radiotherapy planning by fusion of CT and MRI. SPIE Medical Imaging. ... Radiomics based targeted radiotherapy planning (Rad-TRaP): a computational framework for prostate cancer treatment planning ... Integrating Structural and Functional Imaging for Computer Assisted Detection of Prostate Cancer on Multi-Protocol in vivo 3 ... Multimodal Prostate Cancer Prognosis. International Conference on Medical Image Computing and Computer-Assisted Intervention ( ...
more infohttp://engineering.case.edu/centers/ccipd/publications

Cyberknife - WikipediaCyberknife - Wikipedia

"Is CyberKnife Ready for Prime Time in Prostate Cancer?". WSJ. 28 November 2008 Gerszten, P. C.; Ozhasoglu, C; Burton, S. A.; ... a radiation oncologist must plan the delivery of the radiation using a dedicated computer program, after which the treatment ... sdcyberknife.com Fuller CD; Scarbrough TJ (2006). "Fiducial Markers in Image-guided Radiotherapy of the Prostate". US ... The International Journal of Medical Robotics and Computer Assisted Surgery. 1 (2): 19-27. doi:10.1002/rcs.38. PMID 17518375. ...
more infohttps://en.wikipedia.org/wiki/Cyberknife

The International Society for Pharmacoeconomics and Outcomes Research: Implications for Decision Makers in HealthcareThe International Society for Pharmacoeconomics and Outcomes Research: Implications for Decision Makers in Healthcare

... or prostate cancers. Findings included severe toxicities or death associated with image-guided radiotherapy; the maximal ... Diagnostic imaging: computer-assisted breast magnetic resonance imaging (MRI); upright MRI. * Genetic diagnostics: oncotype ... and formularies can be a differentiating factor between plans, which may attract or discourage people from joining a plan. ... Image-guided radiotherapy: Calypso 4D system; Cyberknife. In evaluating the Cyberknife, they looked for evidence for safe and ...
more infohttp://www.ahdbonline.com/issues/2008/july-august-2008-vol-1-no-6/326-article-326

Publications | Center for Computational Imaging and Personalized DiagnosticsPublications | Center for Computational Imaging and Personalized Diagnostics

Computer-assisted targeted therapy (CATT) for prostate radiotherapy planning by fusion of CT and MRI. SPIE Medical Imaging. ... Integrating Structural and Functional Imaging for Computer Assisted Detection of Prostate Cancer on Multi-Protocol in vivo 3 ... Linked Statistical Shape Models for multi-modal segmentation of the prostate on MRI-CT for radiotherapy planning. SPIE Medical ... Concurrent segmentation of the prostate on MRI and CT via linked statistical shape models for radiotherapy planning.. Medical ...
more infohttp://engineering.case.edu/centers/ccipd/publications/author/209

UniversitätsKlinikum Heidelberg: Department of UrologyUniversitätsKlinikum Heidelberg: Department of Urology

... computer-assisted 3D imaging during lapa-roscopic surgery of adrenal glands, kidney, bladder, and prostate) ... radical prostatectomy for prostate cancer (Vinzenz von Czerny, 1893). *perineal radical prostatectomy (Martin Kirschner, b. ... Our administrative staff will be happy to help you and those accompanying you plan a memorable stay. ... Participating departments are Urology, Diagnostic Radiology, Radiotherapy, Clinical Oncology, and Pediatric Oncology. ...
more infohttps://www.klinikum.uni-heidelberg.de/index.php?id=104992&L=1

Fiducial markers and spacers in prostate radiotherapy: current applicationsFiducial markers and spacers in prostate radiotherapy: current applications

Radiotherapy Planning, Computer-Assisted (MeSH) * Radiotherapy, Conformal (MeSH) * Randomized Controlled Trials as Topic (MeSH ... We reviewed the literature on the use of fiducial markers to improve accuracy in delivery of RT for prostate cancer. We discuss ... Fiducial markers and spacers in prostate radiotherapy: current applications Academic Article * View record in Web of Science ® ... OBJECTIVES: To review the use of fiducial markers and spacers in prostate radiotherapy (RT). MATERIALS AND METHODS: ...
more infohttps://scholars.latrobe.edu.au/display/publication100684

JoVE | Peer Reviewed Scientific Video Journal - Methods and ProtocolsJoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols

... breast cancer, Computer-Assisted Diagnosis, computer-aided diagnosis (CAD), entropy, fractional Brownian motion, fractal ... Our laboratory has developed a novel orthotopic implantation model of human prostate cancer (PCa). As PCa death is not due to ... Clinical information such as demographics, cancer characterization, and treatment plans for these patients were abstracted and ... With these techniques, patients hold their breath while radiotherapy is delivered, pushing the heart down and away from the ...
more infohttps://www.jove.com/visualize/abstract/24836053/icotinib-is-an-active-treatment-non-small-cell-lung-cancer

Robotic ultrasound-guided SBRT of the prostate: feasibility with respect to plan quality | SpringerLinkRobotic ultrasound-guided SBRT of the prostate: feasibility with respect to plan quality | SpringerLink

Purpose Advances in radiation therapy delivery systems have enabled motion compensated SBRT of the prostate. A remaining ... Stereotactic body radiotherapy for localized prostate cancer: pooled analysis from a multi-institutional consortium of ... In: Proceedings of the 25th international congress and exhibition on computer assisted radiology and surgery (CARS11), Int J ... Ultrasound-based image guided radiotherapy for prostate cancer: comparison of cross-modality and intramodality methods for ...
more infohttps://link.springer.com/article/10.1007/s11548-016-1455-7

Toward adaptive stereotactic robotic brachytherapy for prostate cancer: Demonstration of an adaptive workflow incorporating...Toward adaptive stereotactic robotic brachytherapy for prostate cancer: Demonstration of an adaptive workflow incorporating...

MRI-guided prostate brachytherapy with single needle method-a planning study. Radiotherapy and Oncology. 2004;71:327-32. [ ... The International Journal of Medical Robotics and Computer Assisted Surgery. 2005;1:40-7. [PubMed] ... Prostate Cancer Clinical Guideline Update Panel. Guideline for the Management of Clinically Localized Prostate Cancer: 2007 ... prostate cancer), and/or easily accommodate naked-eye or ultrasound imaging: Prostate and gynecological cancers (transrectal ...
more infohttp://pubmedcentralcanada.ca/pmcc/articles/PMC3108452/?lang=en-ca

DiVA - Search resultDiVA - Search result

... have been used for registration of CT datasets to evaluate their usability in radiotherapy planning for prostate cancer. These ... Medical Image Computing and Computer-Assisted Intervention - MICCAI 2007. 10th International Conference, Brisbane, Australia, ... 3D deformable registration for monitoring radiotherapy treatment in prostate cancer2007In: Image Analysis: 15th Scandinavian ... In order to use these systems as tools for preoperative planning, it must be possible to generate computer models from real ...
more infohttp://liu.diva-portal.org/smash/resultList.jsf?af=%5B%5D&aq=%5B%5B%7B%22personId%22%3A%22authority-person%3A23697%22%7D%5D%5D&aqe=%5B%5D&aq2=%5B%5B%5D%5D&language=en&query=

Investigating rectal toxicity associated dosimetric features with deformable accumulated rectal surface dose maps for cervical...Investigating rectal toxicity associated dosimetric features with deformable accumulated rectal surface dose maps for cervical...

... knowledge of the dose-toxicity relationship is essential for safe dose escalation to improve local control in cervical cancer ... Dose-surface maps identifying local dose-effects for acute gastrointestinal toxicity after radiotherapy for prostate cancer. ... In International Conference on Medical image computing and computer-assisted intervention. Springer; 2015: 234-241 (Available ... with 4-field box 3D plans or 9 field intensity modulation radiotherapy (IMRT) plans. EBRT plans were delivered with a total ...
more infohttps://rd.springer.com/article/10.1186%2Fs13014-018-1068-0

Main Page/SlicerCommunity/2017 - SlicerWikiMain Page/SlicerCommunity/2017 - SlicerWiki

21 prostate patients received planning 1.5 T MR and CT scans with routine immobilisation devices on a flat-top couch set-up ... MITK-OpenIGTLink for Combining Open-Source Toolkits in Real-Time Computer-Assisted Interventions. Publication: Int J Comput ... 4000+ cancer research citations on Google Scholar (1000+ prostate), (2,320+ brain), (1,310+ lung), (1010+ breast) ... There is increasing interest in MR-only radiotherapy planning since it provides superb soft-tissue contrast without the ...
more infohttps://www.slicer.org/wiki/Main_Page/SlicerCommunity/2017

Main Page/SlicerCommunity/2017 - Slicer WikiMain Page/SlicerCommunity/2017 - Slicer Wiki

21 prostate patients received planning 1.5 T MR and CT scans with routine immobilisation devices on a flat-top couch set-up ... MITK-OpenIGTLink for Combining Open-Source Toolkits in Real-Time Computer-Assisted Interventions. Publication: Int J Comput ... 5400+ cancer research citations on Google Scholar (1300+ prostate), (3,000+ brain), (1,800+ lung), (1,390+ breast) ... There is increasing interest in MR-only radiotherapy planning since it provides superb soft-tissue contrast without the ...
more infohttps://www.slicer.org/wiki/Main_Page/SlicerCommunity-2017

Advanced Technology & Treatments | Aspirus Health CareAdvanced Technology & Treatments | Aspirus Health Care

3-D Conformal Computer Planning. 3-D Conformal Computer Planning is used to accurately determine the position of tumors in ... radiotherapy technology. TrueBeam radiotherapy is not appropriate for all cancers. ... Referred to by many as robotic surgery for prostate cancer, or robotic prostatectomy, da Vinci Prostatectomy is more accurately ... a robot-assisted, minimally invasive surgery that is quickly becoming the preferred treatment for removal of the prostate ...
more infohttps://www.aspirus.org/cancer-treatments-technology

JoVE | Peer Reviewed Scientific Video Journal - Methods and ProtocolsJoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols

We present computer-assisted diagnosis (CAD) software designed to improve prostate cancer detection using perfusion MRI data. ... the optimization of radiotherapy planning, and therapeutic evaluation. We have designed and evaluated a new, nearly automatic ... Computer-assisted diagnosis of prostate cancer using DCE-MRI data: design, implementation and preliminary results. ... Current treatment options for prostate cancer, other than active surveillance, are limited to entire prostate gland destruction ...
more infohttps://www.jove.com/visualize?author=Nacim+Betrouni

Development and clinical application of radiomics in lung cancer | Radiation Oncology | Full TextDevelopment and clinical application of radiomics in lung cancer | Radiation Oncology | Full Text

Computer-assisted solid lung nodule 3D volumetry on CT: influence of scan mode and iterative reconstruction: a CT phantom study ... The integration of PET-CT scans from different hospitals into radiotherapy treatment planning. Radiother Oncol. 2008;87:142-6. ... utility for differentiating non-cancerous prostate from prostate cancer and differentiating prostate cancers with different ... Treatment response and prognostic indication in lung cancer, especially in radiotherapy. Another challenge in lung cancer is ...
more infohttp://ro-journal.biomedcentral.com.preview-live.oscarjournals.springer.com/articles/10.1186/s13014-017-0885-x

Books - Medicine - Terkko NavigatorBooks - Medicine - Terkko Navigator

Cancer, Neoplasms, Radiotherapy Planning, Computer-Assisted, Radiation Oncology, Radiotherapy Planning, Computer-Assisted, ... Prostate biopsy interpretation : an illustrated guide. Prostate, Prostatic Neoplasms, Biopsy, Needle, Pathology, Urology, ... Interventional radiology, Oncology, Cancer, Neoplasm Recurrence, Local, Radiotherapy, Combined Modality Therapy, HEALTH & ... AJCC cancer staging atlas : a companion to the seventh editions of the AJCC cancer staging manual and handbook ...
more infohttps://www.terkko.helsinki.fi/pathology/books

A semiautomatic tool for prostate segmentation in radiotherapy treatment planning | BMC Medical Imaging | Full TextA semiautomatic tool for prostate segmentation in radiotherapy treatment planning | BMC Medical Imaging | Full Text

Medical Image Computing and Computer-Assisted Intervention - MICCAI 2006, Volume 4191 of Lecture Notes in Computer Science. ... Prostate cancer is the second most diagnosed cancer accounting for 14 percent of all cancers diagnosed worldwide [1]. It is ... Our hypothesis is that a more efficient use of physicians in Radiotherapy Treatment Planning (RTP) of patients with prostate ... DelineationEllipse modelEmpirical BayesProstateRadiotherapy treatment planningStatistical shape analysis ...
more infohttps://bmcmedimaging.biomedcentral.com/articles/10.1186/1471-2342-14-4
  • Using a rigorous animal model of spontaneously metastasizing tumors and surgical stress, the enhancement of cancer surgery on the development of lung metastases was demonstrated. (jove.com)
  • Image Guided Radiotherapy (IGRT) - Some tumors may move slightly from day to day, or even during an individual treatment session. (rutgers.edu)
  • While it is known that outcome of prostate cancer (prognosis) is highly correlated with Gleason grade, pathologists often have difficulty in distinguishing between interme- ate Gleason grades from histopathology. (springer.com)
  • Unfortunately there is no standardized ima- based screening protocol for early detection of CAP (unlike for breast cancers). (springer.com)
  • A deep learning based strategy for identifying and associating mitotic activity with gene expression derived risk categories in estrogen receptor positive breast cancers. (case.edu)
  • With recent rapid developments in multi-parametric radiological imaging te- niques (spectroscopy, dynamic contrast enhanced MR imaging, PET, RF ultrasound), some of these functional and metabolic imaging modalities are allowing for definition of high resolution, multi-modal signatures for prostate cancer in vivo. (springer.com)
  • Discriminative Scale Learning (DiScrn): Applications to Prostate Cancer Detection from MRI and Needle Biopsies. (case.edu)
  • Successful deformable image registration is an essential component of both dose accumulation and plan adaptation in radiotherapy. (nih.gov)
  • Radiomics and radiogenomics in lung cancer: A review for the clinician. (case.edu)
  • To develop and validate a robust and accurate registration pipeline for automatic contour propagation for online adaptive Intensity-Modulated Proton Therapy (IMPT) of prostate cancer using elastix software and deep learning. (cdc.gov)
  • Accurate imaging of cancerous tissue is a critical step in the fight to lower cancer mortality rates, and computer-aided detection and diagnosis (CAD) technologies play a key role. (spie.org)
  • A series of steady and incremental improvements over the last twenty years has positioned prostate permanent-seed implants (PPI) among the most popular and efficient modalities to treat prostate cancer, offering one of the highest rates of local disease control ( 1 - 4 ). (pubmedcentralcanada.ca)
  • Additionally, the German Cancer Research Institution (DKFZ) is part of the team, designated the Cooperating Oncologic Group (COG) / Urology. (uni-heidelberg.de)
  • High-throughput detection of prostate cancer in histological sections using probabilistic pariwise Markov models. (upenn.edu)
  • Evaluation of effects of JPEG2000 compression on a computer-aided detection system for prostate cancer on digitized histopathology. (upenn.edu)
  • Computerized Image-Based Detection and Grading of :ymphocytic Infiltration in HER2+Breast Cancer Histopathology. (upenn.edu)
  • Accurate and reproducible invasive breast cancer detection in whole-slide images: A Deep Learning approach for quantifying tumor extent. (case.edu)
  • The proposed registration pipeline achieved a MSD of 1.29 ± 0.39, 1.48 ± 1.16, and 1.49 ± 0.44 mm for the prostate, seminal vesicles, and lymph nodes, respectively, on the second dataset and a MSD of 2.31 ± 1.92 and 1.76 ± 1.39 mm for the prostate and seminal vesicles on the third dataset. (cdc.gov)
  • Co-Registration of ex vivo Surgical Histopathology and in vivo T2 weighted MRI of the Prostate via multi-scale spectral embedding representation. (case.edu)
  • In the USA high levels of prostate-specific antigen (PSA) warrant a trans-rectal ultrasound (TRUS) biopsy to enable histologic confirmation of presence or absence of CAP. (springer.com)
  • Compared to reference plans without the ultrasound robot, the coverage typically drops for all poses. (springer.com)
  • While the blocking of beam directions has a negative effect on the plan quality, the results indicate that a careful choice of the ultrasound robot's pose and a large solid angle covered by beam starting positions can offset this effect. (springer.com)
  • Identifying robot poses that yield acceptable plan quality and allow for intra-fraction ultrasound image guidance, therefore, appears feasible. (springer.com)
  • 13 ] proposes a 3D ellipsoid shape of the prostate in warped transrectal 3D ultrasound images based on control points. (biomedcentral.com)
  • Dosimetry of small static fields used in external photon beam radiotherapy: Summary of TRS-483, the IAEA-AAPM international Code of Practice for reference and relative dose determination. (bioportfolio.com)
  • A joint IAEA/AAPM international working group has developed a Code of Practice (CoP) for the dosimetry of small static fields used in external megavoltage photon beam radiotherapy, published by the IA. (bioportfolio.com)
  • Fixed beam radiotherapy systems utilize couch movement and rotation instead of gantry rotation in order to simplify linear accelerator design. (bioportfolio.com)