Isomeric forms and derivatives of PROPANOL (C3H7OH).
A cyclized derivative of L-GLUTAMIC ACID. Elevated blood levels may be associated with problems of GLUTAMINE or GLUTATHIONE metabolism.
A pathologic condition of acid accumulation or depletion of base in the body. The two main types are RESPIRATORY ACIDOSIS and metabolic acidosis, due to metabolic acid build up.
Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)
A colorless liquid made by oxidation of aliphatic hydrocarbons that is used as a solvent and chemical intermediate.
An isomer of 1-PROPANOL. It is a colorless liquid having disinfectant properties. It is used in the manufacture of acetone and its derivatives and as a solvent. Topically, it is used as an antiseptic.
The balance between acids and bases in the BODY FLUIDS. The pH (HYDROGEN-ION CONCENTRATION) of the arterial BLOOD provides an index for the total body acid-base balance.
A group of genetic disorders of the KIDNEY TUBULES characterized by the accumulation of metabolically produced acids with elevated plasma chloride, hyperchloremic metabolic ACIDOSIS. Defective renal acidification of URINE (proximal tubules) or low renal acid excretion (distal tubules) can lead to complications such as HYPOKALEMIA, hypercalcinuria with NEPHROLITHIASIS and NEPHROCALCINOSIS, and RICKETS.
Substances intended to be applied to the human body for cleansing, beautifying, promoting attractiveness, or altering the appearance without affecting the body's structure or functions. Included in this definition are skin creams, lotions, perfumes, lipsticks, fingernail polishes, eye and facial makeup preparations, permanent waves, hair colors, toothpastes, and deodorants, as well as any material intended for use as a component of a cosmetic product. (U.S. Food & Drug Administration Center for Food Safety & Applied Nutrition Office of Cosmetics Fact Sheet (web page) Feb 1995)
Toluenes in which one hydrogen of the methyl group is substituted by an amino group. Permitted are any substituents on the benzene ring or the amino group.
The outer covering of the body that protects it from the environment. It is composed of the DERMIS and the EPIDERMIS.
The geographic area of Latin America in general and when the specific country or countries are not indicated. It usually includes Central America, South America, Mexico, and the islands of the Caribbean.
The general name for NORTH AMERICA; CENTRAL AMERICA; and SOUTH AMERICA unspecified or combined.
Molecules found on the surface of some, but not all, B-lymphocytes, T-lymphocytes, and macrophages, which recognize and combine with the Fc (crystallizable) portion of immunoglobulin molecules.
A loose confederation of computer communication networks around the world. The networks that make up the Internet are connected through several backbone networks. The Internet grew out of the US Government ARPAnet project and was designed to facilitate information exchange.
Organized services to provide information on any questions an individual might have using databases and other sources. (From Random House Unabridged Dictionary, 2d ed)
The first chemical element in the periodic table. It has the atomic symbol H, atomic number 1, and atomic weight [1.00784; 1.00811]. It exists, under normal conditions, as a colorless, odorless, tasteless, diatomic gas. Hydrogen ions are PROTONS. Besides the common H1 isotope, hydrogen exists as the stable isotope DEUTERIUM and the unstable, radioactive isotope TRITIUM.
A low-energy attractive force between hydrogen and another element. It plays a major role in determining the properties of water, proteins, and other compounds.
The phenomenon whereby certain chemical compounds have structures that are different although the compounds possess the same elemental composition. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)
An ethylene compound with two hydroxy groups (-OH) located on adjacent carbons. They are viscous and colorless liquids. Some are used as anesthetics or hypnotics. However, the class is best known for their use as a coolant or antifreeze.
A highly reactive aldehyde gas formed by oxidation or incomplete combustion of hydrocarbons. In solution, it has a wide range of uses: in the manufacture of resins and textiles, as a disinfectant, and as a laboratory fixative or preservative. Formaldehyde solution (formalin) is considered a hazardous compound, and its vapor toxic. (From Reynolds, Martindale The Extra Pharmacopoeia, 30th ed, p717)
Substances that increase the risk of NEOPLASMS in humans or animals. Both genotoxic chemicals, which affect DNA directly, and nongenotoxic chemicals, which induce neoplasms by other mechanism, are included.
Tests to experimentally measure the tumor-producing/cancer cell-producing potency of an agent by administering the agent (e.g., benzanthracenes) and observing the quantity of tumors or the cell transformation developed over a given period of time. The carcinogenicity value is usually measured as milligrams of agent administered per tumor developed. Though this test differs from the DNA-repair and bacterial microsome MUTAGENICITY TESTS, researchers often attempt to correlate the finding of carcinogenicity values and mutagenicity values.
Derivatives of ACETIC ACID which contain an hydroxy group attached to the methyl carbon.
International organizations which provide health-related or other cooperative services.
Carcinogenic substances that are found in the environment.
Inhibitor of phosphodiesterases.
The terms, expressions, designations, or symbols used in a particular science, discipline, or specialized subject area.
Freedom from exposure to danger and protection from the occurrence or risk of injury or loss. It suggests optimal precautions in the workplace, on the street, in the home, etc., and includes personal safety as well as the safety of property.
Unforeseen occurrences, especially injuries in the course of work-related activities.
Databases devoted to knowledge about specific chemicals.
Substances which are of little or no nutritive value, but are used in the processing or storage of foods or animal feed, especially in the developed countries; includes ANTIOXIDANTS; FOOD PRESERVATIVES; FOOD COLORING AGENTS; FLAVORING AGENTS; ANTI-INFECTIVE AGENTS (both plain and LOCAL); VEHICLES; EXCIPIENTS and other similarly used substances. Many of the same substances are PHARMACEUTIC AIDS when added to pharmaceuticals rather than to foods.
The maximum exposure to a biologically active physical or chemical agent that is allowed during an 8-hour period (a workday) in a population of workers, or during a 24-hour period in the general population, which does not appear to cause appreciable harm, whether immediate or delayed for any period, in the target population. (From Lewis Dictionary of Toxicology, 1st ed)
Alkyl compounds containing a hydroxyl group. They are classified according to relation of the carbon atom: primary alcohols, R-CH2OH; secondary alcohols, R2-CHOH; tertiary alcohols, R3-COH. (From Grant & Hackh's Chemical Dictionary, 5th ed)
A long-acting barbiturate that depresses most metabolic processes at high doses. It is used as a hypnotic and sedative and may induce dependence. Barbital is also used in veterinary practice for central nervous system depression.
A colorless, flammable liquid used in the manufacture of acetic acid, perfumes, and flavors. It is also an intermediate in the metabolism of alcohol. It has a general narcotic action and also causes irritation of mucous membranes. Large doses may cause death from respiratory paralysis.
Antioxidant for foods, fats, oils, ethers, emulsions, waxes, and transformer oils.
City, urban, rural, or suburban areas which are characterized by severe economic deprivation and by accompanying physical and social decay.
The inhabitants of a city or town, including metropolitan areas and suburban areas.

Positive selection of novel peroxisome biogenesis-defective mutants of the yeast Pichia pastoris. (1/231)

We have developed two novel schemes for the direct selection of peroxisome-biogenesis-defective (pex) mutants of the methylotrophic yeast Pichia pastoris. Both schemes take advantage of our observation that methanol-induced pex mutants contain little or no alcohol oxidase (AOX) activity. AOX is a peroxisomal matrix enzyme that catalyzes the first step in the methanol-utilization pathway. One scheme utilizes allyl alcohol, a compound that is not toxic to cells but is oxidized by AOX to acrolein, a compound that is toxic. Exposure of mutagenized populations of AOX-induced cells to allyl alcohol selectively kills AOX-containing cells. However, pex mutants without AOX are able to grow. The second scheme utilizes a P. pastoris strain that is defective in formaldehyde dehydrogenase (FLD), a methanol pathway enzyme required to metabolize formaldehyde, the product of AOX. AOX-induced cells of fld1 strains are sensitive to methanol because of the accumulation of formaldehyde. However, fld1 pex mutants, with little active AOX, do not efficiently oxidize methanol to formaldehyde and therefore are not sensitive to methanol. Using these selections, new pex mutant alleles in previously identified PEX genes have been isolated along with mutants in three previously unidentified PEX groups.  (+info)

Examination of low-incidence brain tumor responses in F344 rats following chemical exposures in National Toxicology Program carcinogenicity studies. (2/231)

Neoplasms in the brain are uncommon in control Fischer 344 (F344) rats; they occur at a rate of less than 1% in 2-yr toxicity/carcinogenicity studies. Furthermore, only 10 of nearly 500 studies conducted by the National Toxicology Program (NTP) showed any evidence of chemically related neoplastic effects in the brain. Generally, the brain tumor responses were considered equivocal, because the characteristics of potential neurocarcinogenic agents (such as statistically significant increased incidences, decreased latency and/or survival, and demonstration of dose-response relationships) were not observed. A thorough examination, including comparisons with a well-established historical database, is often critical in evaluating rare brain tumors. Chemicals that gave equivocal evidence of brain tumor responses were generally associated with carcinogenicity at other sites, and many chemicals were mutagenic when incubated with metabolic activating enzymes. Other factors that were supportive of the theory that marginal increases in brain tumor incidence were related to chemical exposure were that (a) some of the tumors were malignant, (b) no brain neoplasms were observed in concurrent controls from some studies, and/or (c) brain tumors were also seen following exposure to structurally related chemicals. In 2-yr studies in F344 rats (studies conducted by the NTP), equivocal evidence of carcinogenicity was observed for the following 9 chemicals: isoprene, bromoethane, chloroethane, 3,3'-dimethylbenzidine dihydrochloride, 3,3'-dimethoxybenzidine dihydrochloride, furosemide, C.I. direct blue 15, diphenhydramine hydrochloride, and 1-H-benzotriazole. Glycidol was the only chemical evaluated by the NTP with which there was clear evidence of brain tumor induction in F344 rats. Clarification of the potential neurocarcinogenic risks of chemicals that produce equivocal evidence of a brain tumor response in conventional 2-yr rodent studies may be aided by the use of transgenic mouse models that exhibit genetic alterations that reflect those present in human brain tumors as well as by the use of in utero exposures.  (+info)

The evaluation of hypersensitivity tests in cattle after foot-and-mouth disease vaccination. (3/231)

The response to passive cutaneous anaphylaxis, dermal hypersensitivity and intravenous provocation tests has been compared in 30, 40, 31 and 24 cattle injected with foot-and-mouth disease vaccine 0, 1, 2 and 3 times respectively, using vaccine components and other substances as test materials. Reaginic antibodies demonstrated by passive cutaneous anaphylaxis in goats, were directed against BHK 21 cell extracts (20), hydroxypropylmethylcellulose (3) and an unidentified vaccine component (3), and distributed in 0, 5, 19 and 75 per cent of the cattle vaccinated 0, 1, 2 and 3 times. None of the animals showed clinical signs of allergy after vaccination. When BHK 21 cell extract was injected intradermally a significant correlation was noted between the development of large weals and the presence of reagins although the size of the weals was not correlated with the reagin titres. In the case of hydroxypropylmethylcellulose a similar trend was evident. The majority of cattle with large dermal weals possessed reagins but the number of reactions was too small for statistical evaluation. Dermal reactions to sodium penicillin, sodium carboxymethylcellulose, saponin and whole vaccine occurred in both unvaccinated and vaccinated cattle but BHK 21 cell lysate and normal bovine serum provoked weals which increased in frequency according to the number of vaccinations experienced. Intravenous hydroxypropylmethylcellulose elicited a response in all the animals previously injected with certain batches of vaccine but cell extract intravenously produced a clinical response in half the tested animals which was uncorrelated with the results of the passive cutaneous anaphylaxis or dermal hypersensitivity tests.  (+info)

Preparation of synthetic human islet amyloid polypeptide (IAPP) in a stable conformation to enable study of conversion to amyloid-like fibrils. (4/231)

Human synthetic islet amyloid polypeptide (hIAPP) is rapidly converted to beta-sheet conformation and fibrils in aqueous media. Optimal solubility conditions for hIAPP were determined by circular dichroism spectroscopy and transmission electron microscopy. hIAPP in trifluoroethanol or hexafluoro-2-isopropanol (HFIP) diluted in water or phosphate buffer (PB) exhibited random structure which was converted to beta-sheet and fibrils with time. hIAPP, solubilised in HFIP, filtered and lyophilised remained in stable random structure for up to 7 days in water; in PB, insoluble aggregates precipitated from which protofilaments and fibrils formed with time. This suggests that amorphous aggregates of hIAPP could initiate islet amyloidosis in vivo.  (+info)

Fluorinated alcohol, the third group of cosolvents that stabilize the molten-globule state relative to a highly denatured state of cytochrome c. (5/231)

The effects of 1,1,1,3,3,3-hexafluoro-isopropanol (HFIP) on the conformation of cytochrome c (cyt c) at pH 1.9 were studied using a combination of spectroscopic and physical methods. Analysis varying the HFIP concentration showed that a compact denatured conformation (M(HF)) accumulates in a low concentration range of HFIP in the middle of structural transition from the highly unstructured acid-denatured state to the highly helical alcohol-denatured state of cyt c. This contrasts clearly with the effect of isopropanol (IP), in which no compact conformation accompanied with the transition. Analysis varying concentrations of HFIP and NaCl concurrently showed that the M(HF) state of cyt c is essentially identical to the salt-induced molten-globule (M(G)) state, and the M(G) state in the presence of salt was also stabilized by a low concentration of HFIP. Furthermore, 2,2,2-trifluoroethanol stabilized M(HF) similarly to HFIP, supporting the proposition that the specific effect observed for HFIP is caused by fluorination of alcohol. The mechanism stabilizing compact conformation by HFIP remains unclear, but is probably distinct from that of salts and polyols, which are also known to stabilize the M(G)-like state.  (+info)

Pentoxifylline attenuates bacterial lipopolysaccharide-induced enhancement of allyl alcohol hepatotoxicity. (6/231)

Small amounts of exogenous lipopolysaccharide (LPS) (10 ng/kg-100 microg/kg) enhance the hepatotoxicity of allyl alcohol in male Sprague-Dawley rats. This augmentation of allyl alcohol hepatotoxicity appears to be linked to Kupffer cell function, but the mechanism of Kupffer cell involvement is unknown. Since Kupffer cells produce tumor necrosis factor-alpha (TNF alpha) upon exposure to LPS, and this cytokine has been implicated in liver injury from large doses of LPS, we tested the hypothesis that TNF alpha contributes to LPS enhancement of allyl alcohol hepatotoxicity. Rats were treated with LPS (10-100 microg/kg iv) 2 h before allyl alcohol (30 mg/kg ip). Co-treatment with LPS and allyl alcohol caused liver injury as assessed by an increase in activity of alanine aminotransferase in plasma. Treatment with LPS caused an increase in plasma TNF alpha concentration, which was prevented by administration of either pentoxifylline (PTX) (100 mg/kg iv) or anti-TNF alpha serum (1 ml/rat iv) one h prior to LPS. Only PTX protected rats from LPS-induced enhancement of allyl alcohol hepatotoxicity; anti-TNF alpha serum had no effect. Exposure of cultured hepatocytes to LPS (1-10 microg/ml) or to TNF alpha (15-150 ng/ml) for 2 h did not increase the cytotoxicity of allyl alcohol (0.01-200 microM). These data suggest that neither LPS nor TNF alpha alone was sufficient to increase the sensitivity of isolated hepatocytes to allyl alcohol. Furthermore, hepatocytes isolated from rats treated 2 h earlier with LPS (i.e., hepatocytes which were exposed in vivo to TNF alpha and other inflammatory mediators) were no more sensitive to allyl alcohol-induced cytotoxicity than hepatocytes from naive rats. These data suggest that circulating TNF alpha is not involved in the mechanism by which LPS enhances hepatotoxicity of allyl alcohol and that the protective effect of PTX may be due to another of its biological effects.  (+info)

Neonatal induction of tolerance to T(h)2-mediated autoimmunity in rats. (7/231)

Brown-Norway (BN) rats are highly susceptible to drug-induced immune dysregulations and when injected with mercuric chloride (HgCl(2)) or sodium aurothiopropanolsulfonate (ATPS), they develop a syndrome characterized by a polyclonal B cell activation depending upon CD4(+) T(h)2 cells that recognize self-MHC class II molecules. Since peripheral tolerance of T(h)2 cells might be crucial in the prevention of immunological manifestations such as allergy, establishing conditions for inducing tolerance to HgCl(2)- or ATPS-mediated immune manifestations appeared to be of large interest. We report here that BN rats neonatally injected with HgCl(2): (i) do not develop the mercury disease, (ii) remain resistant to HgCl(2)-induced autoimmunity at 8 weeks of age and later, provided they are regularly exposed to HgCl(2), (iii) are still susceptible to ATPS-induced immune manifestations, and (iv) exhibit spleen cells that adoptively transfer tolerance to HgCl(2)-induced autoimmunity in naive, slightly irradiated, syngeneic recipients. These findings demonstrate that dominant specific tolerance can be neonatally induced using a chemical otherwise responsible for T(h)2-mediated autoimmunity.  (+info)

The microaerophilic flagellate Giardia intestinalis: Allium sativum (garlic) is an effective antigiardial. (8/231)

Whole garlic (Allium sativum L.) extract and some of its components were assayed for antigiardial activity. Whole garlic extract gave an IC(50) at 24 h of 0.3 mg ml(-1). Most of the components assayed were inhibitory to the organism, especially allyl alcohol and allyl mercaptan, with IC(50) values of 7 microg ml(-1) and 37 microg ml(-1) respectively. Studies with calcofluor white indicated that whole garlic and allyl alcohol collapse the transmembrane electrochemical membrane potential (Deltapsi) of the organism, as indicated by uptake of the fluorochrome. Electron microscopy allowed the morphological changes that occur with garlic inhibition to be recorded. Both the surface topography and internal architecture of the organism changed during incubation with the biocides. Both whole garlic and allyl alcohol resulted in fragmentation of the disc and an overexpression of disc microribbons, internalization of flagella, vacuole formation and an increase in distended vesicles. Allyl mercaptan, however, only gave an increase in distended vesicles, suggesting that this biocide has a different mode of action.  (+info)

Toxicocinétique et métabolisme Lalcool propargylique (Propargil Alkol, Propargyl Alcohol) est probablement métabolisé en aldéhyde propargylique. Cette oxydation a été démontrée in vitro dans des expériences avec la catalase obtenue à partir de foie de bovin. Des expériences in vitro avec des microsomes hépatiques de rats induits par le phénobarbital ont révélé de faibles niveaux de liaison de lalcool propargylique (Propargil Alkol, Propargyl Alcohol) au cytochrome P450 (BG Chemie 1999). 3 Effets chez lhomme Il ny a pas de données sur les effets chez lhomme dune exposition à lalcool propargylique (Propargil Alkol, Propargyl Alcohol). 262 Propargyl Alcohol (Propargil Alkol, Propargyl Alcohol) Volume 21 Propargyl Alcohol (Propargil Alkol, Propargyl Alcohol) 4 Expérimentation animale et études in vitro 4.1 Toxicité aiguë Lalcool propargylique (Propargil Alkol, Propargyl Alcohol) sest avéré toxique après administration orale, application cutanée et exposition par ...
Sevoflurane [CF3-CH(OCH2F)-CF3] is biotransformed to inorganic fluoride (F-) and hexafluoroisopropanol, which forms a glucuronide conjugate. Although sevoflurane may be used in newborns without fully developed biotransformation activity, studies were performed using liver slices from rat neonates to determine sevoflurane disposition. Sevoflurane was vaporized in sealed roller culture vials to produce a continuous saturating dose (0.5 mM). After incubation, slices and incubation media were sonicated and centrifuged to remove debris. The supernatant fraction was analyzed for F-, hexafluoroisopropanol, and hexafluoroisopropanol-glucuronide conjugate. The metabolism of sevoflurane by liver slices increased proportionately with time with a stoichiometric production (1:1) of hexafluoroisopropanol and F- in all age groups. Only glucuronide conjugates of hexafluoroisopropanol were found. The rate of sevoflurane biotransformation measured as fluoride production was similar among slices prepared from all ...
Nominated Substances: Propargyl alcohol. Nomination Date: 09/20/1996 Nominator: NCI Rationale: Propargyl alcohol is nominated for subchronic studies based on potential for human exposure and a suspicion of carcinogenicity. Propargyl alcohol is a high production volume chemical which is used mainly as a chemical intermediate for a variety of products. It has been identified in air, soil and solid waste. The suspicion of carcinogenicity is based on its metabolism to the aldehyde and positive results in genotoxicity studies. The hepatotoxicity observed in previous studies is similar to that produced by carbon tetrachloride. Chronic toxicity data is lacking. NTP Principles: 1, 2, 7. ...
Involvement of cyclooxygenase-2 in the potentiation of allyl alcohol-induced liver injury by bacterial lipopolysaccharide. - P E Ganey , Y W Barton, S Kinser, R A Sneed, C C Barton, R A Roth
potassium,1,1,1,3,3,3-hexafluoro-2-(trifluoromethyl)propan-2-olate chemical properties, What are the chemical properties of potassium,1,1,1,3,3,3-hexafluoro-2-(trifluoromethyl)propan-2-olate 29646-16-0, What are the physical properties of potassium,1,1,1,3,3,3-hexafluoro-2-(trifluoromethyl)propan-2-olate ect.
see article for more reactions. Abstract. A highly efficient oxidation of propargylic alcohols to ynones is catalyzed by copper nanoparticles (Cu Nps) with TBHP or air as oxidants. With bipyridine as the ligand, the reaction was accelerated significantly and led in good to excellent yields to a variety of propargylic alcohols.. ...
Glucose Decreased & Liver Biopsy showing Periportal Necrosis & Liver Tenderness Symptom Checker: Possible causes include Viral Hepatitis. Check the full list of possible causes and conditions now! Talk to our Chatbot to narrow down your search.
The DABCO-catalyzed reaction of propargyl alcohols with methyl 2-perfluoroalkynoate to give trifluoromethylated furans in up to 98% yield under mild conditions has been developed. The established allene-enol and control experiments indicate that the reaction should proceed through a Michael addition and Claisen rearrangement/cyclization process ...
The 1,3-dipolar cycloaddition of trifluoromethylated propargylic alcohols 1 with azides in the presence of catalytic [Cp*RuCl2], afforded exclusively 4-trifluoroniethyl-1,4,5-trisubstituted-1,2,3-triazoles 2 in high yields. (c) 2008 Elsevier Ltd. All rights reserved ...
Glycidol is an organic compound containing epoxide and alcohol functional groups. It is a clear, slightly viscous liquid that has a variety of industrial uses. Glycidol is used as a stabilizer for natural oils and vinyl polymers and as a demulsifier. It is used as a chemical intermediate in the synthesis of glycerol, glycidyl ethers, esters and amines. It is used in surface coatings, chemical synthesis, pharmaceuticals, sanitary chemicals and sterilizing milk of magnesia, and as a gelation agent in solid propellants.[2] Glycidol is an irritant of the skin, eyes, mucous membranes, and upper respiratory tract. Exposure to glycidol may also cause central nervous system depression, followed by central nervous system stimulation.[3] ...
A one-pot iron-catalyzed conversion of allylic alcohols to a-methyl ketones has been developed. This isomerization-methylation strategy utilized a (cyclopentadienone)iron(0) carbonyl complex as precatalyst and methanol as the C1 source. A diverse range of allylic alcohols undergo isomerization-methylation to form a-methyl ketones in good isolated yields (up to 84% isolated yield).. Analysis of reaction products from this methodology resulted in the following data:. 1H, 19F and 13C NMR raw data files. IR spectra. High resolution mass spectrometry spectra. Research results based upon these data are published at http://doi.org/10.1021/acs.orglett. ...
Materials. The anti-phosphotyrosine antibody PY20 and the anti-paxillin mAb were obtained from Transduction Labs (Lexington, KY). The anti-phosphotyrosine antibody 4G10 was obtained from Upstate Biotechnology (Lake Placid, NY). Anti-FcγRI (mAb 32.2) and anti-FcγRII (mAb IV.3) were obtained from Medarex (Annendale, NJ). Affinity-purified polyclonal antisera to Lyn, Syk, and FAK were obtained from Santa Cruz Biotechnology (Santa Cruz, CA). Affinity-purified horseradish peroxidase-conjugated goat anti-mouse and goat anti-rabbit antibody was obtained from Boehringer Mannheim (Indianapolis, IN). Goat anti-mouse F(ab)2 was obtained from Cappel (West Chester, PA) Peptides corresponding to amino acids 25-35 of Aβ (Aβ25-35), amino acids 1-28 of Aβ (Aβ1-28), and Substance P were obtained from American Peptide (Sunnyvale, CA). Nonfibrillar Aβ1-40 (Bachem, Philadelphia, PA) was prepared by dissociating fibrils in hexafluoroisopropanol, followed by lyophilization and reconstitution in sterile ...
Urinary tract infections are the most common cause of E. coli bloodstream infections (BSI) but the mechanism of bloodstream invasion is poorly understood. Some clinical isolates have been observed to shield themselves with extracellular amyloid fibers called curli at physiologic temperature. We hypothesize that curli fiber assembly at 37 °C promotes bacteremic progression by urinary E. coli strains. Curli expression by cultured E. coli isolates from bacteriuric patients in the presence and absence of bacteremia were compared using Western blotting following amyloid fiber disruption with hexafluoroisopropanol. At 37 °C, urinary isolates from bacteremic patients were more likely to express curli than those from non-bacteremic patients [16/22 (73%) vs. 7/21 (33%); p = 0.01]. No significant difference in curli expression was observed at 30 °C [86% (19/22) vs. 76% (16/21); p = 0.5]. Isolates were clonally diverse between patients, indicating that this phenotype is distributed across multiple ...
A gold(I)-catalysed reaction of allylic alcohols and phenols produces chromans regioselectively via a one-pot Friedel-Crafts allylation/intramolecular
Miscellaneous Databases and IDs: Sigma-Aldrich 81820_FLUKA EPA DSSTox 1883 ChEBI CHEBI:28905 HSDB 6054 ChemIDplus 000107197 ChemSpider 10629399 EINECS 203-471-2 CCRIS 6781 NMRShiftDB 10016645 Beilstein Handbook Reference 4-01-00-02214 ChemDB 3969535 NCGC NCGC00091559-01 DTP/NCI 8804 NIST Chemistry WebBook 1823644871 MMCD cq_03368 MDL ...
CAS Number 382-31-0 Chemical Properties: MDL: MFCD00042309 EINECS: 206-842-7 Formula: CF3CHFCF2CH2OH Flash point: 51°(123°F) Formula weight: 182.07 Density: 1.64 Boiling point: 114-116° Refractive Index: 1.3120
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CAS number: 107-18-6. NIOSH REL: 2 ppm (5 mg/m3) TWA, 4 ppm (10 mg/m3) STEL [skin]. Current OSHA PEL: 2 ppm (5 mg/m3) TWA [skin]. 1989 OSHA PEL: 2 ppm (5 mg/m3) TWA, 4 ppm (10 mg/m3) STEL [skin]. 1993-1994 ACGIH TLV: 2 ppm (4.8 mg/m3) TWA, 4 ppm (9.5 mg/m3) STEL [skin]. Description of substance: Colorless liquid with a pungent, mustard-like odor.. LEL: 2.5% (10% LEL, 2,500 ppm). Original (SCP) IDLH: 150 ppm. Basis for original (SCP) IDLH: The chosen IDLH is based on the statement by AIHA [1963] that from animal experiments, a single 1-hour exposure to 150 ppm might be fatal, while the same exposure to 100 ppm would probably allow survival [Dunlap et al. 1958].. Short-term exposure guidelines: None developed. ...
Vapour and liquid phase infrared spectra of ethanol, 2,2,2-trifluoroethanol, isopropanol and 1,1,1,3,3,3,-hexafluoro-2-propanol were studied. A narrower width is found for several specific ro-vibrational bands in liquid spectra as compared to those of the vapours. Detailed analysis of the band contours suggests that the rotatory motion for liquid alcohols is anisotropic. © 1979 ...
Propargyl methacrylate | C7H8O2 | Cid 83778 : framework, chemical type bands, external and additionally chemical premises, distinction, patents, literary mastery, neurological things to do.
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Treatment of propargyl ureas or guanidines with iodosobenzene diacetate results in an oxidative tandem amination/etherification dearomatizing spirocyclization. This transformation leads directly to the complete framework of the Leucetta alkaloids, spirocalcaridine A and B.
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From a process chemists point of view this reaction is not scalable (and it should be 2 steps). Now I know its not the job of research to do process chemistry research, but to substantiate the claim of scalability a minimum of process work should be carried out and reported.. Inspite of using 10 equivalents of SeO2 the yield is only 52%, why? What is the rest of the material? Why is 10 equivalents required? What is the consequence of only a 90% yield of the silylation reaction? How do the side products from that reaction affect the oxidation, is this the reason for 10 equivalents of SeO2? What is the thermal profile of this reaction? What is the minimum amount of SeO2 needed? What happens to the selenium waste? Is the 52% reproducible? What about the quality of the allyl alcohol for the next step? All these questions and more need to be answered before the reaction could be called scalable.. No I am not decrying the excellent synthetic work of this group, rather I would caution the use of the ...
The present invention relates to a mild method of reducing a C-O bond to the corresponding C-H bond in a substrate, which could be a benzylic alcohol, allylic alcohol, ester or an ether bond beta to a hydroxyl group or alpha to a carbony ...
The dual extrusion electrospinning technique was used to fabricate multilayered 3D scaffolds by stacking microfibrous meshes of poly(lactic acid-co-glycolic acid) (PLGA) in alternate fashion to micro/nano mixed fibrous meshes of PLGA and collagen. To fabricate the multilayered scaffold, 35 wt% solution of PLGA in THF-DMF binary solvent (3:1) and 5 wt% solution of collagen in hexafluoroisopropanol (HFIP) with and without hydroxyapatite nanorods (nHA) were used. The dual and individual electrospinning of PLGA and collagen were carried out at flow rates of 1.0 and 0.5 mL/h, respectively, at an applied voltage of 20 kV. The density of collagen fibers in multilayered scaffolds has controlled the adhesion, proliferation, and osteogenic differentiation of MC3T3-E1 cells. The homogeneous dispersion of glutamic acid-modified hydroxyapatite nanorods (nHA-GA) in collagen solution has improved the osteogenic properties of fabricated multilayered scaffolds. The fabricated multilayered scaffolds were characterized
TY - JOUR. T1 - Reaction of Copper Enolates of Esters with Propargylic Systems. Facile Preparation of 3, 4-Dienoic Esters, Stereoselective Rearrangement to (2E,4Z)- and (2E,4E)-Dienoic Esters, and Stereoselective Synthesis of a Fragrance from the Bartlett Pear. AU - Amos, Richard A.. AU - Katzenellenbogen, John A.. PY - 1978. Y1 - 1978. N2 - A copper enolate species derived by treatment of the lithium enolate of ethyl acetate with cuprous iodide has been found to react with propargyl bromide cleanly in an Sn2′ manner to give ethyl 3, 4-pentadienoate, a β-allenic ester. Under the same conditions, the lithium enolate gives only ethyl 4-pentynoate, the corresponding β-acetylenic ester, resulting from direct Sn2 displacement. The reaction of propargylic methanesulfonates having an alkyl group at the propargylic position shows the same remarkable effect of enolate counterion; with the copper enolate, higher homologues of the β-allenic esters can be synthesized efficiently. Copper can act in a ...
0029] Suitable iodinated cure site monomers include iodinated olefins of the formula: CHR═CH--Z--CH2CHR--I, wherein R is --H or --CH3; Z is a C1-C18 (per)fluoroalkylene radical, linear or branched, optionally containing one or more ether oxygen atoms, or a (per)fluoropolyoxyalkylene radical as disclosed in U.S. Pat. No. 5,674,959. Other examples of useful iodinated cure site monomers are unsaturated ethers of the formula: I(CH2CF2CF2)nOCF═CF2 and ICH2CF2O[CF(CF3)CF2O]nCF═CF2, and the like, wherein n=1-3, such as disclosed in U.S. Pat. No. 5,717,036. In addition, suitable iodinated cure site monomers including iodoethylene, 4-iodo-3,3,4,4-tetrafluorobutene-1(ITFB); 3-chloro-4-iodo-3,4,4-trifluorobutene; 2-iodo -1,1,2,2-tetrafluoro-1-(vinyloxy)ethane; 2-iodo-1-(perfluorovinyloxy)-1,1,-2,2-tetrafluoroethylene; 1,1,2,3,3,3-hexafluoro-2-iodo-1-(perfluorovinyloxy)propane; 2-iodoethyl vinyl ether; 3,3,4,5,5,5-hexafluoro-4-iodopentene; and iodotrifluoroethylene are disclosed in U.S. Pat. No. ...
TY - JOUR. T1 - Iron-catalyzed carbometalation of propargylic and homopropargylic alcohols. AU - Zhang, Donghui. AU - Ready, Joseph M.. PY - 2006/11/29. Y1 - 2006/11/29. N2 - Nucleophilic addition to alkynes represents an attractive approach to the synthesis of olefins. Obstacles to this strategy include the low reactivity of alkynes toward many organometallic reagents and difficulties associated with controlling the regioselectivity of addition. Here we demonstrate that Fe(III) salts are effective precatalysts for the carbometalation of alkynes. Primary and secondary propargylic and homopropargylic alcohols react with alkyl and aryl Grignard reagents to provide Z-allylic and -homoallylic alcohols as single stereo and regioisomers. Alkylation and arylation occur distal to the alcohol. Common oxygen protecting groups and tertiary nitrogens are tolerated. The intermediate vinyl magnesium or iron species can be trapped with a variety of electrophiles including aldehydes, allyl bromide, and ...
An efficient one-pot procedure was designed by integration of the pincer-complex-catalyzed borylation of allyl alcohols in the Petasis borono-Mannich reaction and in allylation of aldehydes and ketones. These procedures are suitable for one-pot synthesis of α-amino acids and homoallyl alcohols from easily available allyl alcohol, amine, aldehyde, or ketone substrates. In the presented transformations, the active allylating agents are in situ generated allyl boronic acid derivatives. These transient intermediates are proved to be reasonably acid-, base-, alcohol-, water-, and air-stable species, which allows a high level of compatibility with the reaction conditions of the allylation of various aldehyde/ketone and imine electrophiles. The boronate source of the reaction is diboronic acid or in situ hydrolyzed diboronate ester ensuring that the waste product of the reaction is nontoxic boric acid. The regio- and stereoselectivity of the reaction is excellent, as almost all products form as single ...
C(sp3)-H versus C(sp3)-C(sp) in Activation of Propargylic Amines under Transition-Metal CatalysisC(sp3)-H versus C(sp3)-C(sp) in Activation of Propargylic Amines under Transition-Metal Catalysis ...
The Kuwajima Taxol total synthesis by the group of Isao Kuwajima of the Tokyo Institute of Technology is one of several efforts in taxol total synthesis published in the 1990s. The total synthesis of Taxol is considered a landmark in organic synthesis. This synthesis is truly synthetic without any help from small biomolecule precursors and also a linear synthesis with molecule ring construction in the order of A, B, C, D. At some point chirality is locked into the molecule via an asymmetric synthesis step which is unique compared to the other efforts. In common with the other efforts the tail addition is based on the Ojima lactam. The 20 carbon frame is constructed from several pieces: propargyl alcohol (C1, C2, C14), propionaldehyde (C13, C12, C18), isobutyric acid (C15, C16, C17, C11), Trimethyl(phenylthiomethyl)silane (C10), 2-bromobenzaldehyde (C3 to C9), diethylaluminum cyanide (C19) and trimethylsilylmethyl bromide (C20) Ring A synthesis (scheme 1) started by joining the THP protected ...
A practical and environmentally benign Brønsted acid−catalyzed protocol for the preparation of all-carbon tetrasubstituted allenes, consisting in the direct SNˈ addition of tri- or dimethoxy arenes or allyltrimethylsilane to tertiary propargylic alcohols, has been developed. In addition, a straightforward synthesis of densely substituted 2H-chromenes by metal-free tandem allenylation/heterocyclization reaction of methoxyphenols and tertiary alkynols is presented ...
I\ /I I1 II 1 International Edition in English A Journal __ of the Gesellschaft Deutscher Chemiker 1995134 2-3/24 Pages 2571 -2796 COVER PICTURE The cover picture shows a ball-and-stick model of a multicyclophane described by an achiral K 3 , stereoelement. K 3 . graphs consist of two sets of three points where each point in one set is connected to every point in the other set. In the multicyclophane shown. these six points are the red and blue benzene rings. J. S. Siege1 et al. report more on pages 2657-2660 on this multicyclophane and its D,,-symmetric isomer, which have dimensions on the order of nanometers in terms of length and kilodaltons in terms of weight. The picture was generated with the program QMView developed by Kim K. Baldridge and Jerry Greenberg at the San Diego Supercomputer Center. REVIEWS Owing to the ready availability of propargylic alcohols and their esters by the reaction of terminal alkynes with carbonyl compounds, their Pd-catalyzed reactions hold great potential in ...
EFSA was asked to deliver a scientific opinion on free and esterified 3- and 2-monochloropropane-1, 2-diol (MCPD) and glycidyl esters in food. Esters of 3- and 2-MCPD and glycidol are contaminants of processed vegetable oils; free MCPDs are formed in some processed foods. The Panel on Contaminants in the Food Chain (CONTAM Panel) evaluated 7,175 occurrence data. Esters of 3- and 2-MCPD and glycidyl esters were found at the highest levels in palm oil/fat, but most vegetable oil/fats contain substantial quantities. Mean middle bound (MB) dietary exposure values to total 3-MCPD, 2-MCPD and glycidol, respectively, across surveys and age groups in μg/kg body weight (bw) per day were 0.2-1.5, 0.1-0.7 and 0.1-0.9; high exposure (P95) values were 0.3-2.6, 0.2-1.2 and 0.2-2.1. Animal studies show extensive hydrolysis of esterified 3-MCPD and glycidol following oral administration; esterified and free forms were assumed to contribute equally to internal exposures. Nephrotoxicity was consistently observed ...
The production of vegetable oils and their respective secondary products is a complex and challenging process. Product quality, homogeneity and purity depend on a multitude of parameters. Although the production of vegetable oils and fats is a well-established and controlled process, two problematic by-products, namely 3-monochloro-propane-1,2-diol (3-MCPD) and 2,3-epoxypropanol (glycidol) are formed during the refining process. 3-MCPD and glycidol are highly suspected to be carcinogenic and genotoxic in humans. Therefore, great efforts to optimize the refining process for a minimal 3-MCPD and glycidol formation have already been made. However, knowledge about detailed mechanisms and possible influence of raw material parameters on 3-MCPD formation is still lacking.. Thus, one important research focus within the value chain of vegetable oils and products thereof is the evaluation of various raw oil and pressing parameters to avoid the formation of these undesired compounds in edible oils. ...
Page contains details about ATTO-740-conjugated poly(propargyl 3-methylpentenoate oxide-co-ε-caprolactone) nanoparticles . It has composition images, properties, Characterization methods, synthesis, applications and reference articles : nano.nature.com
Allyl chloride definition, a colorless, volatile, flammable liquid, C 3 H 5 Cl, having a pungent odor, derived from propylene by chlorination: used chiefly in the synthesis of allyl alcohol, resins, and pharmaceuticals. See more.
Glycidol serves as a building block in chemical synthesis of surfactants, pharmaceuticals, cosmetics, and resins. Ethers based on glycidol are used as reactive diluents for coatings and paints. ...
allyl alcohol is 47 mol% and the conversion of hydrogen peroxide is 94 mol%. The experiments at the molar ratios of AA/H 2 O 2 , 1 were not conducted, because according to the literature data [ 14 ], the excess of H 2 O 2 in the post-reaction solution. ...
synthesized in turn, from the P-keto ester 6. For the synthesis of 6 we started with enone 1, readily prepared following a known procedure.6 The analysis of the IH NMR spectrum of the reaction product of its reduction revealed the presence of a 2: 1 mixture of allylic alcohols and also that the acetal moiety had been hydrolyzed, presumably during the work-up, giving directly 8. Scheme 1 @ C02Me - 4 5 683 0 I JJ pco C02Me 6 684 J. A. BACIGALUPPO eta/. We have found no precedent in the literature for the hydrolysis of acetals under these conditions. Without. ...
3-(2-Aminopyridin-3-yl)propan-1-ol Cas No 89226-78-8 - A wide of 3-(2-Aminopyridin-3-yl)propan-1-ol knowledge covers characteristics, safety, usage, MSDS/SDS & Reach registration data at Echemi.com
Looking for SPECTRUM Cinnamyl Acetate,25ml (26WR97)? Graingers got your back. Price:$36.20. Easy ordering & convenient delivery. Log-in or register for your pricing.
[1-(4-Aminobenzoyl)oxy-2-methylpropan-2-yl]-propan-2-ylazanium; hydrogensulfate/ACM69781200 can be provided in Alfa Chemistry. We are dedicated to provide our customers the best products and services.
Product page for 3-(dimethylamino)-1-(3-nitrophenyl)propan-1-one hydrochloride, CAS number 63352-94-3, Molecular Formula C11H15ClN2O3.
Buy ALLYL CHLORIDE, 98% online here at chemexresearch! | Right Price Chemicals offers a complete line of chemicals including the following ALLYL ...
|p |Silia|em||span style=color: #f37021;|Bond|/span||/em||sup|® |/sup|Allyl (Si-Allyl) can be used as solid support for further derivatization.|/p| |p||a href={{media url=specsheets/spec-R53530B.pdf}} target=_blank|PRODUCT SPECIFICATIONS|
Prof. Karl Heinrich Bauer was one of the founders of the German Cancer Research Center (DKFZ) in Heidelberg. After his medical studies, K.H. Bauer specialized in surgery, at least in part due to the urgent need for surgeons during World War I. After the war, he specialized in genetics, a study that brought him on the path of cancer research.In 1928, he published his first paper on cancer, Die Mutationstheorie der Geschwulstbildung (The role of genetic mutations in Cancer). He was appointed as professor in Breslau in 1933, where surgery was his main focus of research. On 1 January 1943, K. H. Bauer became the head of the Surgery Clinic of the University of Heidelberg. At the conclusion of World War II, when the American troops marched into Heidelberg, the university was closed down. On 15 August 1949, under Bauers leadership and with new statutes, the University of Heidelberg was the first German university to re-open. In the following years, Bauer dedicated more of his time on cancer ...
Yes, or more precisely 2-phenyl-1-propanol. I have edited my typos above. Doesnt it sometimes give the 1-phenyl-2-propanol (up ... Friedel-Crafts alkylation of benzene only gives 2-phenyl-1-propanol and no 1-phenyl-2-propanol (P2Pol), this in contrast to the ... Friedel-Crafts alkylation of benzene only gives 2-phenyl-2-propanol and no 1-phenyl-2-propanol (P2Pol). But our russian ... Friedel-Crafts alkylation of benzene only gives 2-phenyl-2-propanol and no 1-phenyl-2-propanol (P2Pol), ...
Methoxy-1, Propanol-2 (CH3OCH2CH(OH)CH3) (2) * Methoxy-1, Propanol-2 (CH3OCH2CH(OH)CH3) (2) ...
Isopropanol = 2-Methyl-(1)-Propanol (often used for desinfecting and so on). 2. removing scratches:. by polishing:. so you can ... According to the declaration of one mixture it contains a simple organic compuond called 2-methyl-1-propanol (alchohol ...
  • 1-Propanol is thought to be similar to ethanol in its effects on the human body, but 2-4 times more potent. (wikipedia.org)
  • Update: August 12, 2020 -- FDA is warning consumers and health care professionals about certain hand sanitizer products, including those manufactured by Harmonic Nature S de RL de MI in Mexico, that are labeled to contain ethanol or isopropyl alcohol but have tested positive for 1-propanol contamination. (drugs.com)
  • Animal studies indicate that the central nervous system depressant effects of 1-propanol are 2 to 4 times as potent as alcohol (ethanol). (drugs.com)
  • This lack of effect was surprising based on predictions from the structural similarity of 1-propanol to ethanol and on long standing observations that toxicity increases with carbon chain length among the aliphatic alcohols. (cdc.gov)
  • Chemical 3 h recovery (%) Standard every 15 min for 3 h (%) Methanol 109 107 Formaldehyde 85 95 Acetaldehyde 44 76 Acrolein 10 53 Propionaldehyde 41 75 Ethanol 95 123 Acetone 74 97 2-Propanol 90 103 Table 4. (thefreedictionary.com)
  • Maginn, E. J. Monte Carlo simulation and SAFT modeling study of the solvation thermodynamics of dimethylformamide, dimethylsulfoxide, ethanol and 1-propanol in the ionic liquid trimethylbutylammonium bis(trifluoromethylsulfonyl)imide. (alfa.com)
  • A method for analysis of methanol, ethanol, and propanol at submicromolar levels in aqueous samples has been developed. (uncg.edu)
  • Alcohol concentrations in enzyme blanks were 0.44 ± 0.01 µM for methanol, 0.050 ± 0.004 µM for ethanol, and 0.15 ± 0.04 µM for propanol. (uncg.edu)
  • Percent conversions under optimum conditions were 90.1% ± 2% RSD for methanol, 40% ± 3% RSD for ethanol, and 7% ± 3% RSD for propanol. (uncg.edu)
  • Excess molar volumes have been evaluated from density measurements over the entire composition range for binary systems of an ionic liquid (IL) and an alcohol at T = (298.15, 303.15 and 313.15) K. The IL is 1-butyl-3-methylimidazolium methylsulphate [BMIM] + [MeSO 4 ] - and the alcohols are methanol, ethanol or 1-propanol. (journals.co.za)
  • After identifying the better eluent (ethanol) and optimum temperature (25°C), we achieved 100% separation of (R,S)-2,3-dichloro-1-propanol from the aqueous phase and recovery from the resin. (alliedacademies.org)
  • n -Propanol and n -butanol induced the appearance of a mitochondrial cyanide-insensitive respiration without affecting the normal cytochrome chain whereas methanol and ethanol had no effect. (microbiologyresearch.org)
  • Consumers who have products on the list of hand sanitizers with potential methanol or 1-propanol contamination should immediately stop using the product and dispose of it, ideally in a hazardous waste container . (drugs.com)
  • 1-Propanol, n-propanol, or propan-1-ol : CH3CH2CH2OH, the most common meaning 2-Propanol, Isopropyl alcohol, isopropanol, or propan-2-ol : (CH3)2CHOH Propanal (propionaldehyde) differs in spelling from propanol by a single letter and is a different compound. (wikipedia.org)
  • 1-propanol, not to be confused with 2-propanol/isopropanol/isopropyl alcohol, is not an acceptable ingredient for hand sanitizer products marketed in the United States and can be toxic and life-threatening when ingested. (drugs.com)
  • Evaluates the risks to human health and the environment posed by the production and use of 2-propanol, a liquid widely used as a low-cost solvent in industry and in the home. (indigo.ca)
  • PROPAN-1-OL (n-PROPANOL) Explanation This extraction solvent was evaluated for acceptable daily intake for man by the Joint FAO/WHO Expert Committee on Food Additives in 1980 (see Annex, Ref. 54). (inchem.org)
  • What's more,Its systematic name is 1-Propanol.It is a colorless liquid made by oxidation of aliphatic hydrocarbons that is used as a solvent and chemical intermediate.It may form peroxides in contact with air.And it is incompatible with alkali metals, alkaline earths, aluminium, oxidizing agents, nitro compounds,highly flammable.And it is used as a solvent in the pharmaceutical industry, and for resins and cellulose esters. (lookchem.com)
  • The polymers were stabilized with DBPC, coagulated from 2-propanol and steam desolventized or passed through a drum-dryer to remove residual solvent. (thefreedictionary.com)
  • 1-Propanol is used as a solvent and an entrainer in azeotropic distillation. (alfa.com)
  • Çehreli, S., Özmen, D., Dramur, U.: (Liquid + liquid) equilibria of (water + 1-propanol + solvent) at T = 298.2 K. Fluid Phase Equilib. (springer.com)
  • The study provides a decisive view of the global propanol market by segmenting it in terms of product type (iso-propanol and n-propanol) and applications such solvent, chemical intermediate, cosmetics & pharmaceuticals, others (Cleansers, adhesives, agricultural chemicals, etc. (mrrse.com)
  • In North America and Mexico, n-propyl acetate and n-propanol will increase $0.03/lb. (pcimag.com)
  • This report focuses on the N-propanol in global market, especially in North America, Europe and Asia-Pacific, South America, Middle East and Africa. (rnrmarketresearch.com)
  • Regional segmentation includes current and forecast demand for propanol in North America, Europe, Asia Pacific, Latin America, and Middle East & Africa. (mrrse.com)
  • The report then estimates 2016-2021 market development trends of 1-[Bis[3-(dimethylamino)propyl]amino]-2-propanol industry. (reportsnreports.com)
  • The report provides the actual market size of propanol for 2016 and estimated market size for 2017 with forecast for the next eight years. (mrrse.com)
  • Skin or eye exposure to 1-propanol can result in irritation, and rare cases of allergic skin reactions have been reported. (drugs.com)
  • The authors conclude that it is unlikely that exposure to 1-propanol at work will produce functional effects at levels lower than those required to produce malformations. (cdc.gov)
  • H 2C=CH 2 + CO + H 2 → CH 3CH 2CH=O CH 3CH 2CH=O + H 2 → CH 3CH 2CH 2OH A traditional laboratory preparation of 1-propanol involves treating n-propyl iodide with moist Ag 2O. (wikipedia.org)
  • Oxidation of 1-propanol with Na 2Cr 2O 7 and H 2SO 4 gives only a 36% yield of propionaldehyde, and therefore for this type of reaction higher yielding methods using PCC or the Swern oxidation are recommended. (wikipedia.org)
  • The catalytic activity of all the electrodes in 2-Propanol oxidation was measured by cyclic voltammetry. (thefreedictionary.com)
  • Photocatalytic oxidation of 2-propanol in the gas. (brillonline.com)
  • CO 2 from both commercially available source, as well as generated in situ through 2-propanol oxidation, was used for this study. (brillonline.com)
  • 1-Propanol is a primary alcohol with the formula CH 3CH 2CH 2OH and sometimes represented as PrOH or n-PrOH. (wikipedia.org)
  • 1-Propanol shows the normal reactions of a primary alcohol. (wikipedia.org)
  • M] se hace mas positivo con el incremento de la longitud de cadena del alcohol desde 2-propanol hasta 2-pentanol. (thefreedictionary.com)
  • N-propanol (n-propyl alcohol), a three-carbon straight chain oxo alcohol, is a medium boiling, colorless liquid that is widely used in flexographic and other printing ink applications. (rnrmarketresearch.com)
  • Propanol is a colorless alcohol typically available in two types of isomers: iso-propanol and n-propanol. (mrrse.com)
  • N-propanol is a used in the coatings industry as a medium-volatile alcohol for improving the drying characteristics of alkyd resins, electro deposition paints, and baking finishes. (mrrse.com)
  • 2 ] devised a synthetic approach to convert 2-ketobutyrate to produce 1-propanol in a genetically engineered E. coli strain through a non-fermentative biosynthetic pathway mediated by a promiscuous 2-ketoacid decarboxylase and an aldehyde/alcohol dehydrogenase (ADH). (biomedcentral.com)
  • Liquid-liquid equilibrium (LLE) date for the ternary systems of {water + 1-propanol + dibutyl ether (DBE)} and (water + 1-butanol + DBE) were determined at T = (293.15, 303.15, 308.15) K under atmospheric pressure. (springer.com)
  • 3-Cyclohexyl-1-propanol and 3-cyclohexyl-1-butanol rank among synthetic fragrant compounds. (perfumerflavorist.com)
  • N-butanol production by the upstream ethylene prices greater impact, most enterprises will be processed into sales propanol acetate, acrylic ester compound. (rnrmarketresearch.com)
  • There are two isomers of propanol. (wikipedia.org)
  • whether 3,3-dimethyl-1-propanol is a isomers of c5h12o? (yahoo.com)
  • The new facility "Propanol 2" is now being commissioned and is scheduled for commercial production in the third quarter of 2018. (businesswire.com)
  • 3-(BENZYLMETHYLAMINO)-1-PROPANOL (CAS 5814-42-6) Market Research Report 2018 contents were worked out and placed on the website in March, 2018. (marketpublishers.com)
  • Please note that 3-(BENZYLMETHYLAMINO)-1-PROPANOL (CAS 5814-42-6) Market Research Report 2018 is a half ready publication and contents are subject to change. (marketpublishers.com)
  • Adi YK, Widayanti R, Pangestiningsih TW (2018) n-Propanol extract of boiled and fermented koro benguk (Mucuna pruriens seed) shows a neuroprotective effect in paraquat dichloride-induced Parkinson's disease rat model, Veterinary World, 11(9): 1250-1254. (veterinaryworld.org)
  • It is a colorless liquid and an isomer of 2-propanol. (wikipedia.org)
  • The report generally describes 3-(benzylmethylamino)-1-propanol, examines its uses, production methods, patents. (marketpublishers.com)
  • 3-(benzylmethylamino)-1-propanol manufacturers and suppliers with contacts and product range are mentioned in the study. (marketpublishers.com)
  • The rate of H 2 production in N 2 -purged aqueous solutions containing 0.1% TiO 2 suspension were evaluated to be 0.226 and 5.8 μl/h, without and with 0.5 M 2-propanol, respectively. (brillonline.com)
  • The formation of both CO and CH 4 in the photolysis of CO 2 -purged aqueous solutions containing suspended TiO 2 in absence of 2-propanol reveal that the generation of CH 4 is taking place mainly through CO intermediate. (brillonline.com)
  • 145-153Boiling Point Propylene Glycol Propyl Ether 1- Propoxy -2- Propanol Large Image 145-153Boiling Point Propylene Glycol Propyl Ether 1- Propoxy -2- Propanol Product Details: Place of Origin: China Brand Name: YIDA Certification: ISO/18001/14001/SGS. (ismap.com)
  • Description:Dipropylene glycol monomethyl ether (also known as Methoxy Propoxy Propanol , Oxybispropanol, dipropylene glycol methyl ether, DPM, and Dowanol DPM) is a propylene oxide-based, glycol ether. (ismap.com)
  • Reaction with acetic acid in the presence of an H 2SO 4 catalyst under Fischer esterification conditions gives propyl acetate, while refluxing propanol overnight with formic acid alone can produce propyl formate in 65% yield. (wikipedia.org)
  • In South America, n-propyl acetate and n-propanol will increase $66/mt. (pcimag.com)
  • Propanol are also primarily used to manufacture chemicals such as propyl halide, propyl amines, propyl acetate, and glycol ethers. (mrrse.com)
  • Rising cosmetics industry is therefore expected to propel the propanol market during the forecast period, owing to its use in various cosmetics and personal care applications. (mrrse.com)
  • It also covers impact of these drivers and restraints on demand for propanol during the forecast period. (mrrse.com)
  • Ghanadzadeh, H., Ghanadzadeh, A., Bahrpaima, K.: Measurement and prediction of tie-line data for mixtures of (water + 1-propanol + diisopropyl ether): LLE diagrams as a function of temperature. (springer.com)
  • Dipropylene Glycol Methyl Ether, Dipropylene glycol mono methyl ether DPM 1 - (2-methoxy propoxy )-2- propanol . (ismap.com)
  • Our offered (IUPAC name 2-propanol) is a chemical compound with the molecular formula C3H8O or C3H7OH or CH3CHOHCH3. (tradeindia.com)
  • The worldwide market for N-propanol is expected to grow at a CAGR of roughly 3.7% over the next five years, will reach 980 million US$ in 2023, from 790 million US$ in 2017, according to a new GIR (Global Info Research) study. (rnrmarketresearch.com)
  • Described are D-(threo)-1-aryl-2-acylamido-3-fluoro-1-propanol esters and salts thereof, methods for their preparation, and methods for their use as antibacterial agents. (google.com)
  • Synthesis of ( 1RS,2SR )-( )-2-amino-1-phenyl-1-propanol ( 2 ) by reductive amination of ( R )-(-)-1-hydroxy-1-phenyl-2-propanone ( 1 ) using ammonia and Raney nickel as a catalyst was investigated. (erowid.org)
  • The (S)-2,3-dichloro-1-propanol ((S)-2,3-DCP) can be used as a key precursor for the synthesis of (R)-epichlorohydrins, β-blockers, L-carnitine and Platelet Activating Factor (PAF) [8,9]. (alliedacademies.org)
  • In this study, we manipulated a novel metabolic pathway for the synthesis of 1-propanol in the genetically tractable bacterium Escherichia coli . (biomedcentral.com)
  • Up to now, the production of 1-propanol primarily relies on chemical synthesis and no microbial cells have been identified as a natural 1-propanol producer. (biomedcentral.com)
  • 1RS,2SR )-( )-2-Amino-1-phenyl-1-propanol (compound 2 ) is a good vasoconstricting agent and clinically used as a nasal decongestant. (erowid.org)
  • In this study, we show that an inhibitor of glycosphingolipid biosynthesis, D, l -threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol (PDMP), increases the chemosensitivity of neuroblastoma tumor cells for Taxol and vincristine. (aacrjournals.org)
  • Click the button below to add the (R)-(+)-1-Phenyl-1-propanol 100mg to your wish list. (p212121.com)
  • R,S)-2,3-dichloro-1-propanol ((R,S)-2,3-DCP) in the enantio pure form is useful as chiral building blocks for the production of industrial and pharmaceutical important chemicals. (alliedacademies.org)
  • Distribution coefficients and separation factors of 1-propanol in the mixtures were calculated and are discussed. (springer.com)
  • Cháfer, A., de la Torre, J., Lladosa, E., Montón, J.B.: Liquid-liquid equilibria of 4-methyl-2-pentanone + 1-propanol or 2-propanol + water ternary systems: measurements and correlation at different temperatures. (springer.com)
  • For the ternary mixture ([C-2 OHmim] [PF6] + dichloromethane + 2-propanol), a moderate pressure effect on the cloud point with a negative pressure-temperature slope was detected. (lancs.ac.uk)
  • Brains from ten rats per group were dissected and assayed for protein, acetylcholine, dopamine, norepinephrine, serotonin, beta-endorphin, Met-enkephalin, and substance-P. The results indicated that exposure to high concentrations of 1-propanol affected fertility in exposed males, but no consistent effects were noted in the behavioral or neurochemical tests measured. (cdc.gov)
  • At these levels of exposure 1-propanol is not a selective developmental toxicant, and exposure to concentrations of 1-propanol as carried out in this research will likely not result in behavioral teratogenicity. (cdc.gov)
  • Because of its cooling, antipyretic, rubefacient, cleaning, and antiseptic properties, 2-propanol is used to produce a large number of household and personal products, including topically applied pharmaceutical products and cosmetics. (indigo.ca)
  • The agency urges consumers not to use these 1-propanol-contaminated products and has expanded its do-not-use list of hand sanitizers at www.fda.gov/unsafehandsanitizers to include hand sanitizers that are or may be contaminated with 1-propanol, in addition to other hand sanitizers the agency is urging consumers not to use. (drugs.com)
  • Top sale 71-23-8 1-Propanol with best price Our main products: Crovell is specialized in pharmaceutical intermediates, veterinary drug intermediates and dyes intermediates,such as phenylacetamide, dimethylamine hcl, benzyl chloride etc. (lookchem.com)
  • Which of the following statement(s) about 2-methyl-1-propanol, (CH3)2CHCH2OH, and 1,3-propanediol, HOCH2CH2CH2OH are true?Possible answers: A.) 2-Methyl-1-propanol is more soluble in water than. (enotes.com)
  • A.) 2-Methyl-1-propanol is more soluble in water than is 1,3-propanediol because 2-methyl-1-propanol has a smaller molecular mass. (enotes.com)
  • C.)2-Methyl-1-propanol is more soluble in water than is 1,3-propanediol because 2-methyl-1-propanol forms fewer hydrogen bonds with water. (enotes.com)
  • Propanol has also been used as a major raw material to manufacture acetone. (mrrse.com)
  • However, rising production of acetone through cumene process is anticipated to remarkably affected the propanol market. (mrrse.com)
  • The report provides key statistics on the market status of the 1-[Bis[3-(dimethylamino)propyl]amino]-2-propanol manufacturers and is a valuable source of guidance and direction for companies and individuals interested in the industry.Firstly, the report provides a basic overview of the industry including its definition, applications and manufacturing technology. (reportsnreports.com)
  • Through the statistical analysis, the report depicts the global and Chinese total market of 1-[Bis[3-(dimethylamino)propyl]amino]-2-propanol industry including capacity, production, production value, cost/profit, supply/demand and Chinese import/export. (reportsnreports.com)
  • In the end, the report makes some important proposals for a new project of 1-[Bis[3-(dimethylamino)propyl]amino]-2-propanol Industry before evaluating its feasibility. (reportsnreports.com)
  • Overall, the report provides an in-depth insight of 2011-2021 global and Chinese 1-[Bis[3-(dimethylamino)propyl]amino]-2-propanol industry covering all important parameters. (reportsnreports.com)
  • 1-Propanol is manufactured by catalytic hydrogenation of propionaldehyde. (wikipedia.org)
  • More specifically, this invention relates to novel 1-aryl-2-acylamido-3-fluoro-1-propanol antibacterial agents, to methods for their manufacture and to novel intermediates useful therein, to pharmaceutical compositions comprising said 1-aryl-2-acylamido-3-fluoro-1-propanols and to methods for their use in treating antibacterial infections. (google.com)
  • Whereas the heats of adsorption of 1-propanol at the adsorption equilibrium was found to be dependent to the surface coverage with E θ0 =67 kJ/mol and E θ1 =58 kJ/mol at 475 Pa. (omicsonline.org)
  • Demand for propanol is projected to increase significantly in the next few years considering the extensive growth of the pharmaceutical industry in various regions. (mrrse.com)

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