Megestrol acetate is a progestogen with actions and uses similar to those of the progestogens in general. It also has anti-androgenic properties. It is given by mouth in the palliative treatment or as an adjunct to other therapy in endometrial carcinoma and in breast cancer. Megestrol acetate has been approved to treat anorexia and cachexia. (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Englewood, CO, 1995)
Receptor, Melanocortin, Type 4
A 28-amino acid, acylated, orexigenic peptide that is a ligand for GROWTH HORMONE SECRETAGOGUE RECEPTORS. Ghrelin is widely expressed but primarily in the stomach in the adults. Ghrelin acts centrally to stimulate growth hormone secretion and food intake, and peripherally to regulate energy homeostasis. Its large precursor protein, known as appetite-regulating hormone or motilin-related peptide, contains ghrelin and obestatin.
Peptides derived from pro-opiomelanocortin (POMC) which can stimulate MELANOCYTES or CORTICOTROPHS. Melanocortins include ACTH; ALPHA-MSH; and other peptides such as BETA-MSH and GAMMA-MSH, derived from other fragments of POMC. These peptides act through a variety of MELANOCORTIN RECEPTORS to control different functions including steroidogenesis, energy homeostasis, feeding, and skin pigmentation.
A bibliographic database that includes MEDLINE as its primary subset. It is produced by the National Center for Biotechnology Information (NCBI), part of the NATIONAL LIBRARY OF MEDICINE. PubMed, which is searchable through NLM's Web site, also includes access to additional citations to selected life sciences journals not in MEDLINE, and links to other resources such as the full-text of articles at participating publishers' Web sites, NCBI's molecular biology databases, and PubMed Central.
Biological Science Disciplines
All of the divisions of the natural sciences dealing with the various aspects of the phenomena of life and vital processes. The concept includes anatomy and physiology, biochemistry and biophysics, and the biology of animals, plants, and microorganisms. It should be differentiated from BIOLOGY, one of its subdivisions, concerned specifically with the origin and life processes of living organisms.
Completed forms of the pharmaceutical preparation in which prescribed doses of medication are included. They are designed to resist action by gastric fluids, prevent vomiting and nausea, reduce or alleviate the undesirable taste and smells associated with oral administration, achieve a high concentration of drug at target site, or produce a delayed or long-acting drug effect.
Oxygen Inhalation Therapy
Any method of artificial breathing that employs mechanical or non-mechanical means to force the air into and out of the lungs. Artificial respiration or ventilation is used in individuals who have stopped breathing or have RESPIRATORY INSUFFICIENCY to increase their intake of oxygen (O2) and excretion of carbon dioxide (CO2).
Encyclopedias as Topic
Members of the class of compounds composed of AMINO ACIDS joined together by peptide bonds between adjacent amino acids into linear, branched or cyclical structures. OLIGOPEPTIDES are composed of approximately 2-12 amino acids. Polypeptides are composed of approximately 13 or more amino acids. PROTEINS are linear polypeptides that are normally synthesized on RIBOSOMES.
A glycosylated form of the N-terminal peptide may be associated with cachexia (muscle wasting) in cancer patients. Survival ... The N-terminal peptide, also known as diffusible survival evasion peptide, promotes neural cell survival under conditions of ... 1998). "Identification of a survival-promoting peptide in medium conditioned by oxidatively stressed cell lines of nervous ... "Characterization of a human homologue of proteolysis-inducing factor and its role in cancer cachexia". Clin. Cancer Res. 10 (17 ...
Subsequently, they bring areas of rRNA close together and promote the processing of pre-rRNA and the recruitment of ribosomal ... Connolly, Martin (2017). "miR-424-5p reduces ribosomal RNA and protein synthesis in muscle wasting". Journal of Cachexia, ... "The DEAH-box helicase Dhr1 dissociates U3 from the pre-rRNA to promote formation of the central pseudoknot". PLOS Biology. 13 ( ...
Stefan D. Anker
"Journal of Cachexia, Sarcopenia and Muscle". Wiley Online Library. "Journal of Cachexia, Sarcopenia and Muscle". Cite journal ... promoting self-care in persons with heart failure: a scientific statement from the American Heart Association." (Riegel et al ... "SCWD - Sarcopenia, Cachexia and Wasting Disorders". Sarcopenia, Cachexia and Wasting Disorders. Retrieved 2017-05-17. Search ... "Endpoints for Cachexia Trials & Nutrition for Cachexia and Sarcopenia" (Morley et al., JAMDA 2010) Nutritional recommendations ...
MGA is used mainly as an appetite stimulant to promote weight gain in a variety of situations. When given at very high dosages ... Argilés JM, Anguera A, Stemmler B (June 2013). "A new look at an old drug for the treatment of cancer cachexia: megestrol ... Mantovani G, Macciò A, Lai P, Massa E, Ghiani M, Santona MC (1998). "Cytokine involvement in cancer anorexia/cachexia: role of ... MGA is frequently used as an appetite stimulant to promote weight gain. The direct mechanism of appetite enhancement is unclear ...
... is produced early by the fetal lung and promotes lung growth. Umbilical cord blood levels of ghrelin show a correlation ... Ghrelin levels are high in people with cancer-induced cachexia. There is insufficient evidence to conclude either for or ... May 2005). "Active ghrelin levels and active to total ghrelin ratio in cancer-induced cachexia". The Journal of Clinical ... "Ghrelin for the management of cachexia associated with cancer". The Cochrane Database of Systematic Reviews. 2: CD012229. doi: ...
Andrew Stewart Coats
His research turned established teaching on its head and promoted exercise training (rather than bed rest) as a treatment for ... His Imperial College patents have formed the basis of companies specialising in the treatment of cachexia (Myotec and PsiOxus ...
... evidence indicates tumors themselves are an important source of factors that may promote cachexia in cancer. Tumor-derived ... and laboratory changes to categorize patients into non-cachexia, pre-cachexia, cachexia, and refractory cachexia. The Cachexia ... Cachexia is also a significant problem in South America and Africa. The most frequent causes of cachexia in the United States ... Cachexia is also distinct from sarcopenia, or age-related muscle loss, although they often co-exist. The management of cachexia ...
... and other supplements for the treatment of cachexia in cancer: a European Palliative Care Research Centre cachexia project". ... to promote wound healing following surgery or injury, or when otherwise recommended by a medical professional. It is a powdered ... The efficacy of Juven for the treatment of cancer cachexia was also examined in a phase 3 clinical trial which found a strong ... Further research involving the treatment of cancer cachexia with Juven over a period of several months is required to ...
Beta-Hydroxy beta-methylbutyric acid
... but not rheumatoid cachexia. Further research involving the treatment of cancer cachexia with Juven over a period of several ... to promote wound healing following surgery or injury, or when otherwise recommended by a medical professional. Juven, a ... in turn promoting protein synthesis through increased mTOR phosphorylation. Based upon limited clinical evidence in humans, ... and muscle strength that occurs in hypercatabolic disease states such as cancer cachexia; consequently, the authors of two 2016 ...
Pathological states that increase cardiac stress and promote heart failure can induce a rise in both cardiac myostatin mRNA and ... Increases in myostatin levels during chronic heart failure have been shown to cause cardiac cachexia. Systemic inhibition of ... In vitro studies indicate that myostatin promotes SMAD2 phosphorylation to inhibit cardiomyocyte proliferation. Furthermore, ... Pathological cardiac stress promotes N-terminal cleavage by furin convertase to create a biologically active C-terminal ...
They would have fewer side-effects, while still promoting muscle and bone tissue growth and regeneration. These claims are, ... cachexia - which is a syndrome that is a co-morbidity of cancer and congestive heart failure; chronic obstructive pulmonary ... "cachexia" in these disease settings have a poor prognosis. Moreover, starvation eventually leads to muscle atrophy. Disuse of ... as a potent stimulator of protein synthesis as well as an inhibitor of protein breakdown in the extreme case of cachexia.65, 72 ...
Tumor necrosis factor
TNF in neurons promotes their survival, whereas TNF in macrophages and microglia results in neurotoxins that induce apoptosis. ... In 1985, Bruce A. Beutler and Anthony Cerami discovered that cachectin (a hormone which induces cachexia) was actually TNF. ... TNF promotes the inflammatory response, which, in turn, causes many of the clinical problems associated with autoimmune ... TNF1 signaling tends to be pro-inflammatory and apoptotic, whereas TNFR2 signaling is anti-inflammatory and promotes cell ...
Leukemia inhibitory factor
LIF promotes self-renewal by recruiting signal transducer and activator of transcription 3 (Stat3). Stat3 is recruited to the ... cachexia, neural development, embryogenesis and inflammation. p53 regulated LIF has been shown to facilitate implantation in ... "Purification of a lipoprotein lipase-inhibiting protein produced by a melanoma cell line associated with cancer cachexia". ...
On June 3, 2010, Maren appeared at Turning Stone Resort & Casino in Verona, New York to promote a new Wizard of Oz slot machine ... from a combination of old age-related diseases including cachexia, heart failure and senile dementia. Maren left no immediate ...
Melanocortin 4 receptor
Foster AC, Chen C (2007). "Melanocortin-4 receptor antagonists as potential therapeutics in the treatment of cachexia". Current ... have been found to promote pair bond formation in prairie voles and, due to these prosocial effects, have been suggested as ... while MC4 receptor antagonists have attracted interest as potential treatments for cachexia. MC4 receptor agonists like ...
"Journal of Cachexia, Sarcopenia and Muscle. 6 (3): 208-11. doi:10.1002/jcsm.12055. PMC 4575551. PMID 26401466.. ... Parents can thus promote physical activity and limit the amount of time children spend in front of screens. ... "Cancer cachexia: rationale for the MENAC (Multimodal-Exercise, Nutrition and Anti-inflammatory medication for Cachexia) trial ... Resistance training and subsequent consumption of a protein-rich meal promotes muscle hypertrophy and gains in muscle strength ...
The cachexia of old age 1987 R. Goulding, Poisoning as a social phenomenon 1988 J.E. Cotes, Occupational health today and ... Promoting the public's health: lessons from east and west 2012 Gareth Williams, Flat learning curve: why the anti-vaccination ...
They would have fewer side effects, while still promoting muscle and bone tissue growth and regeneration. These claims are, ... and muscle strength in hypercatabolic disease states such as cancer cachexia; consequently, as of June 2016[update] ... cachexia, which is a syndrome that is a co-morbidity of cancer and congestive heart failure; chronic obstructive pulmonary ... "cachexia" in these disease settings have a poor prognosis. Moreover, starvation eventually leads to muscle atrophy. ...
Furthermore, cord factor's production of TNF-α, also known as cachectin, is also able to induce cachexia, or loss of weight, ... Lee, WB; Kang, JS; Yan, JJ; Lee, MS; Jeon, BY; Cho, SN; Kim, YJ (2012). "Neutrophils Promote Mycobacterial Trehalose Dimycolate ... Silva, CL; Faccioli, LH (December 1988). "Tumor necrosis factor (cachectin) mediates induction of cachexia by cord factor from ... These cytokines can lead to further cytokine production that promote inflammatory responses. Cord factor, through the Mincle ...
Legal history of cannabis in Canada
... cachexia, anorexia, weight loss, and/or severe nausea from cancer or HIV/AIDS infection Severe pain from severe forms of ... and Kevin Smith and Jason Mewes known as Jay and Silent Bob will be promoting Beleave Inc. Stars from the popular Canadian show ... several celebrities have agreed to promote specific brands. Tweed Inc. will be producing and distributing Snoop Dogg's Leafs by ... outlaws the sale and display of cannabis-related merchandise and makes it difficult to publicly promote cannabis once legalized ...
Often fast food, low in cost and nutrition, is high in calories and heavily promoted. When these eating habits are combined ... Clinical malnutrition, such as cachexia, is a major burden also in developed countries. Various scales of analysis also have to ... Breastfeeding can reduce rates of malnutrition and death in children, and some efforts to promote the practice have been ... In particular Goal 2: Zero hunger sets globally agreed targets to end hunger, all forms of malnutrition and promote sustainable ...
Yin Y, Hua H, Li M, Liu S, Kong Q, Shao T, Wang J, Luo Y, Wang Q, Luo T, Jiang Y (January 2016). "mTORC2 promotes type I ... cancer cachexia, and muscle atrophy from physical inactivity. mTORC2 activation appears to mediate neurite outgrowth in ... As a core component of mTORC2, mTOR also functions as a tyrosine protein kinase that promotes the activation of insulin ... p70S6K activation has been shown to promote tangle formation as well as mTOR hyperactivity through increased phosphorylation ...
"Cancer cachexia: rationale for the MENAC (Multimodal-Exercise, Nutrition and Anti-inflammatory medication for Cachexia) trial ... Parents can thus promote physical activity and limit the amount of time children spend in front of screens. Children who are ... Although there is only limited scientific evidence on the subject, people with cancer cachexia are encouraged to engage in ... Grande AJ, Silva V, Maddocks M (September 2015). "Exercise for cancer cachexia in adults: Executive summary of a Cochrane ...
Weight loss or loss of appetite ("cachexia") is an effect of some diseases, and a side effect of some prescription drugs. ... decreased response to satiety may promote development of obesity. It has been found that ghrelin-reactive IgG immunoglobulins ... Dysregulation of appetite contributes to anorexia nervosa, bulimia nervosa, cachexia, overeating, and binge eating disorder. A ... "Ghrelin as a promising therapeutic option for cancer cachexia". Cellular Physiology and Biochemistry. 48 (5): 2172-2188. doi: ...
Osteosarcoma may be promoted by growth hormones. Some treatments and prevention approaches leverage this cause by artificially ... Some cancers can cause a systemic inflammatory state that leads to ongoing muscle loss and weakness, known as cachexia. Some ... Some hormones play a role in the development of cancer by promoting cell proliferation. Insulin-like growth factors and their ... Aging's effect on cancer is complicated by factors such as DNA damage and inflammation promoting it and factors such as ...
Karl August Nerger
The official cause of death was reported as cachexia, but, according to former inmate Heinz Masuch, Nerger was actually beaten ... and was promoted to Fregattenkapitän on 13 January 1917. In May 1918, he became commander of minesweeper units of the High Seas ...
Tumor necrosis factor alpha
In 1985, Bruce A. Beutler and Anthony Cerami discovered that cachectin (a hormone which induces cachexia) was actually TNF. ... TNF promotes the inflammatory response, which, in turn, causes many of the clinical problems associated with autoimmune ... TNF, being an endogenous pyrogen, is able to induce fever, apoptotic cell death, cachexia, inflammation and to inhibit ... It is a potent chemoattractant for neutrophils, and promotes the expression of adhesion molecules on endothelial cells, helping ...
Multiple system atrophy
Some deaths are caused by cachexia, also known as wasting syndrome. Multiple system atrophy is estimated to affect ... of aggregated conformers that may differentially promote pathological prion-like spread. In 2020, researchers at The University ...
Chronic obstructive pulmonary disease
... promoting smoking cessation, checking workers for early signs of COPD, use of respirators, and dust control. Effective ... cachexia) may occur. Low levels of physical activity are associated with worse outcomes. ...
Kaeberlein M.; McVey M.; Guarente L. (1999). "The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae ... or of the cachexia (wasting syndrome) and sarcopenia (loss of muscle mass, structure, and function). One study linked a ...
Cannabinoids are used in patients with cachexia, cytotoxic nausea, and vomiting, or who are unresponsive to other agents. These ... Kast RE, Foley KF (July 2007). "Cancer chemotherapy and cachexia: mirtazapine and olanzapine are 5-HT3 antagonists with good ...
It aims to promote health and to prevent and treat diseases and disabilities in older adults. ...
Wikipedia:Plain and simple guide for medical editors
Wiki Med promotes patient rights and safety in media sharing. Political advocacy. Main article: Meta:Wiki Medicine/ ... Society and culture (e.g., cachexia was a literary symbol for tuberculosis in the 19th century and for AIDS in the 1980s.) ... Other editors have promoted the inclusion of long-term survivors of normally deadly diseases to "give other patients hope". ... This organization participates in the Wikipedia Loves Libraries program by promoting events at medical and health science ...
The ACE inhibitor enalapril has also been shown to reduce cardiac cachexia in patients with chronic heart failure. Cachexia ... Wang, Guojun; Sun, Junfeng; Liu, Guanghui; Fu, Yang; Zhang, Xiefu (2017-07-31). "Bradykinin Promotes Cell Proliferation, ... "J Cachexia Sarcopenia Muscle. 1 (2): 129-133. doi:10.1007/s13539-010-0014-2. PMC 3060646. PMID 21475695.. ... preliminary findings in cardiac cachexia". European Journal of Heart Failure. 3 (3): 359-63. doi:10.1016/S1388-9842(00)00146-X ...
Once discovered, vitamins were actively promoted in articles and advertisements in McCall's, Good Housekeeping, and other media ... They promoted foods such as yeast cakes, a source of B vitamins, on the basis of scientifically-determined nutritional value, ... outlets. Marketers enthusiastically promoted cod-liver oil, a source of Vitamin D, as "bottled sunshine", and bananas as a ...
DNA repair-deficiency disorder
... cachexia (loss of subcutaneous fat tissue), sensorineural deafness, retinal degeneration, and calcification of the central ... "SIRT7 promotes genome integrity and modulates non-homologous end joining DNA repair". EMBO J. 35 (14): 1488-503. doi:10.15252/ ...
Omega-3 fatty acid
... or that the intake of n-6 fatty acids has a promoting role in the context of atopic diseases. ... In people with advanced cancer and cachexia, omega−3 fatty acids supplements may be of benefit, improving appetite, weight, and ... "N-3 fatty acids, cancer and cachexia: a systematic review of the literature". The British Journal of Nutrition. 97 (5): 823-31 ...
Some hormones play a role in the development of cancer by promoting cell proliferation. Insulin-like growth factors and ... "Definition and classification of cancer cachexia: an international consensus". The Lancet Oncology. 12 (5): 489-495. doi: ... Oncogenes are genes that promote cell growth and reproduction. Tumor suppressor genes are genes that inhibit cell division and ... Also, immunomodulators and biologic agents used to treat these diseases may promote developing extra-intestinal malignancies.[ ...
Specifically, BDNF promotes survival of dorsal root ganglion neurons. Even when bound to a truncated TrkB, BDNF still shows ... "Ciliary neurotrophic factor activates leptin-like pathways and reduces body fat, without cachexia or rebound weight gain, even ... Nerve growth factor (NGF) uses the high-affinity receptor TrkA to promote myelination and the differentiation of ... In the mature nervous system, they promote neuronal survival, induce synaptic plasticity, and modulate the formation of long- ...
Clinical malnutrition, such as cachexia, is a major burden also in developed countries. Various scales of analysis also have to ... Often fast food, low in cost and nutrition, is high in calories and heavily promoted. When these eating habits are combined ... Sguassero, Y; de Onis, M; Bonotti, AM; Carroli, G (Jun 13, 2012). "Community-based supplementary feeding for promoting the ... and efforts to promote the practice increase the rates of breastfeeding. In young children, providing food (in addition to ...
Ciliary neurotrophic factor
... without cachexia or rebound weight gain, even in leptin-resistant obesity". Proc. Natl. Acad. Sci. U.S.A. 98 (8): 4652-7. doi: ... is a polypeptide hormone and neurotrophic factor whose actions have mainly been studied in the nervous system where it promotes ...
In some particularly local cancers, such as pancreatic cancer, this is particularly noticeable: the patient dies of cachexia, ... Barcellos-Hoff, Mary Helen; Ravani, Shraddha A. (2000-03-01). "Irradiated Mammary Gland Stroma Promotes the Expression of ...
Cannabis in Oregon
The other conditions are given as epilepsy, HIV/AIDS, cancer, cachexia, chronic glaucoma and tremors caused by Alzheimer's ... The Oregon Marijuana Initiative spent about $50,000 promoting the proposition, and collected the 87,000 signatures necessary to ...
Abstract 447: ZAG promotes cachexia-associated white adipose tissue browning and energy wastage | Cancer Research
Abstract 447: ZAG promotes cachexia-associated white adipose tissue browning and energy wastage. Sawsan Elattar and ... ZAG promotes cachexia-associated white adipose tissue browning and energy wastage [abstract]. In: Proceedings of the American ... Abstract 447: ZAG promotes cachexia-associated white adipose tissue browning and energy wastage ... Abstract 447: ZAG promotes cachexia-associated white adipose tissue browning and energy wastage ...
Cancer Cachexia: Mechanisms and Clinical Implications
Cachexia is compounded by anorexia and the relationship between these two entities has not been clarified fully. ... Inconsistencies in the definition of cachexia have limited the epidemiological characterisation of the condition and there has ... Cachexia is a multifactorial process of skeletal muscle and adipose tissue atrophy resulting in progressive weight loss. It is ... and counteracts the action of MC4R-stimulating proteins promoting appetite . These "appetite neurons" also express ...
Inter-tissue communication in cancer cachexia | Nature Reviews Endocrinology
In this Review, Josep M. Argilés and colleagues discuss the role of different tissues and organs in cancer cachexia and examine ... Cachexia is a multi-organ syndrome associated with cancer. ... Interleukin-6 induces fat loss in cancer cachexia by promoting ... Cachexia is a systemic condition that occurs during many neoplastic diseases, such as cancer. Cachexia in cancer is ... Cachexia: a problem of energetic inefficiency. J. Cachexia Sarcopenia Muscle 5, 279-286 (2014). ...
Frontiers | The Skeletal Muscle as an Active Player Against Cancer Cachexia | Physiology
... wasting of both adipose tissue and skeletal muscle and reduced survival rates are among the main features of cachexia. Skeletal ... wasting of both adipose tissue and skeletal muscle and reduced survival rates are among the main features of cachexia. Skeletal ... The management of cancer patients is frequently complicated by the occurrence of cachexia. This is a complex syndrome that ... The management of cancer patients is frequently complicated by the occurrence of cachexia. This is a complex syndrome that ...
Angiotensin type 2 receptor activation promotes browning of white adipose tissue and brown adipogenesis | Signal Transduction...
AT2R activation promotes WAT browning and reduces WAT mass in vivo. To further investigate the role of AT2R in WAT browning in ... Angiotensin type 2 receptor activation promotes browning of white adipose tissue and brown adipogenesis. *Aung Than1. *, ... All these suggest that AngII promotes the browning of white adipocytes by stimulating the expressions of PPARγ and PRDM16 via ... UCP1 promotes mitochondrial respiration and heat generation by decreasing the proton gradient generated in oxidative ...
OSM potentiates preintravasation events, increases CTC counts, and promotes breast cancer metastasis to the lung | SpringerLink
... indicative of cachexia (Additional file 4: Figure S3B). It was previously reported that cachexia, elevated inflammatory factors ... J Cachexia Sarcopenia Muscle. 2011;2(1):9-25.CrossRefPubMedPubMedCentralGoogle Scholar ... Inflammation based regulation of cancer cachexia. Biomed Res Int. 2014;2014:168407.CrossRefPubMedPubMedCentralGoogle Scholar ... Novel function of oncostatin M as a potent tumour-promoting agent in lung. Int J Cancer. 2015;136(4):831-43.CrossRefPubMed ...
Frontiers | The Impact of Immune Cells on the Skeletal Muscle Microenvironment During Cancer Cachexia | Physiology
Cachexias complexity has provided a barrier for developing successful therapies to prevent or treat the condition, since a ... Cachexias complexity has provided a barrier for developing successful therapies to prevent or treat the condition, since a ... termed cachexia, is a common comorbidity associated with cancer that results in adverse consequences for the patient related to ... 2013). NF-kappaB-mediated Pax7 dysregulation in the muscle microenvironment promotes cancer cachexia. J. Clin. Invest. 123, ...
NF-κB Promotes Muscle Wasting in Transgenic Mice | Science Signaling
The impact of exercise training on adipose tissue remodelling in cancer cachexia | Porto Biomedical Journal
Indeed, both conditions promote WAT browning but distinct mechanisms are probably involved. Whereas cancer cachexia-related ... The interplay between cancer cachexia and exercise training. In the set of cancer cachexia, the therapeutic effect of exercise ... 55 Exercise training reduces or circumvents the cachexia-related ghrelin resistance by promoting positive changes in the ... Cancer cachexia (CC) is a syndrome associated with poor prognosis, being responsible for about 20% of deaths in cancer patients ...
Interleukin-1α Promotes Tumor Growth and Cachexia in MCF-7 Xenograft Model of Breast Cancer<...
Interleukin-1α Promotes Tumor Growth and Cachexia in MCF-7 Xenograft Model of Breast Cancer. In: American Journal of Pathology ... Interleukin-1α Promotes Tumor Growth and Cachexia in MCF-7 Xenograft Model of Breast Cancer. American Journal of Pathology. ... Interleukin-1α Promotes Tumor Growth and Cachexia in MCF-7 Xenograft Model of Breast Cancer. / Kumar, Suresh; Kishimoto, ... Fingerprint Dive into the research topics of Interleukin-1α Promotes Tumor Growth and Cachexia in MCF-7 Xenograft Model of ...
Polkey MI[au] - PubMed - NCBI
MicroRNA-542 Promotes Mitochondrial Dysfunction and SMAD Activity and Is Elevated in Intensive Care Unit-acquired Weakness. ... J Cachexia Sarcopenia Muscle. 2018 Apr;9(2):400-416. doi: 10.1002/jcsm.12266. Epub 2017 Dec 7. ... J Cachexia Sarcopenia Muscle. 2018 Feb;9(1):119-128. doi: 10.1002/jcsm.12236. Epub 2017 Oct 6. ... J Cachexia Sarcopenia Muscle. 2019 Jun 17. doi: 10.1002/jcsm.12463. [Epub ahead of print] ...
Cytokines Flashcards by Carol Haak | Brainscape
Contribution of Neuroinflammation to the Pathogenesis of Cancer Cachexia
... biological response modifiers and the family of cell adhesion-promoting molecules. ... K. C. H. Fearon and A. G. W. Moses, "Cancer cachexia," International Journal of Cardiology, vol. 85, no. 1, pp. 73-81, 2002. ... O. Kayacan, D. Karnak, S. Beder et al., "Impact of TNF-α and IL-6 levels on development of cachexia in newly diagnosed NSCLC ... A. Laviano, A. Inui, D. L. Marks et al., "Neural control of the anorexia-cachexia syndrome," The American Journal of Physiology ...
Solid Dosage Form That Promotes Reliable Oral, Esophageal and GI Transit - FUISZ RICHARD C.
METHODS FOR TREATING CACHEXIA AND LYMPHOPENIA. April, 2010. Davies. 20080040082. Modeling systems for consumer goods. February ... Previous Patent: Solid Dosage Form That Promotes Reliable Oral, Esophageal and GI Transit. Next Patent: OIL-BASED PREPARATION ... Reducing adhesion promotes successful transit. One way that we accomplish this is through the asymmetrical dosage since this ... It is an object of the present invention to comprise and manufacture a solid dosage form designed to promote more rapid and ...
Nerve Growth Factor Links Oral Cancer Progression, Pain, and Cachexia | Molecular Cancer Therapeutics
NGF is tumor promoting for a variety of cancers and anti-NGF has been shown to reduce tumor proliferation. Andriaenssens and ... Nerve Growth Factor Links Oral Cancer Progression, Pain, and Cachexia. Yi Ye, Dongmin Dang, Jianan Zhang, Chi T. Viet, David K. ... Nerve Growth Factor Links Oral Cancer Progression, Pain, and Cachexia. Yi Ye, Dongmin Dang, Jianan Zhang, Chi T. Viet, David K. ... Nerve Growth Factor Links Oral Cancer Progression, Pain, and Cachexia. Yi Ye, Dongmin Dang, Jianan Zhang, Chi T. Viet, David K. ...
Depletion of stromal cells expressing fibroblast activation protein-α from skeletal muscle and bone marrow results in cachexia...
Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in ... Reversal of cancer cachexia and muscle wasting by ActRIIB antagonism leads to prolonged survival. Cell. 142:531-543. doi: ... Induction of cachexia in mice by systemically administered myostatin. Science. 296:1486-1488. doi:10.1126/science.1069525. ... Cachexia: a new definition. Clin. Nutr. 27:793-799. doi:10.1016/j.clnu.2008.06.013. ...
Anti-TNF-α Antibody and Cancer Cachexia | Springer for Research & Development
Cachexia is characterised by accelerated loss of adipose tissue and skeletal muscle in the context of a chronic inflammatory ... Balkwill F (2002) Tumor necrosis factor or tumor promoting factor? Cytokine Growth Factor Rev 13:135-141PubMedCrossRefGoogle ... de Witte M., Anderson M., Robinson D. (2006) Anti-TNF-α Antibody and Cancer Cachexia. In: Mantovani G. et al. (eds) Cachexia ... Argiles JM, Lopez-Soriano J, Busquets S et al (1997) Journey from cachexia to obesity by TNF. FASEB J 11:743-751PubMedGoogle ...
Myostatin promotes distinct responses on protein metabolism of skeletal and cardiac muscle fibers of rodents
Myostatin induces cachexia by activating the ubiquitin proteolytic system through an NF-kappaB-independent, FoxO1-dependent ... 24) demonstrated that myostatin promotes autophagy in C2C12 cells in the absence of horse serum in the medium. They have also ... The early onset trigger in Smad phosphorylation promoted a reduction in p-Akt (30%), and a remarkable decrease in p-FoxO3a (70 ... Here, we found that myostatin increased the phosphorylation of Smad3 in soleus and EDL muscles and promoted an increase in ...
Guttridge DC[au] - PubMed - NCBI
Microvesicles containing miRNAs promote muscle cell death in cancer cachexia via TLR7. ... NF-κB-mediated Pax7 dysregulation in the muscle microenvironment promotes cancer cachexia. ... Cancer cachexia update in head and neck cancer: Pathophysiology and treatment.. Couch ME, Dittus K, Toth MJ, Willis MS, ... The TLR7/8/9 antagonist IMO-8503 inhibits cancer-induced cachexia.. Croce CM, Calore F, Londhe P, Fadda P, Nigita G, Casadei L ...
Screening for Cancer | The Second Fifty Years: Promoting Health and Preventing Disability | The National Academies Press
Generalized weakness associated with cachexia of cancer and with chemotherapy.. Disability. * Behavioral difficulties, ... The Second Fifty Years: Promoting Health and Preventing Disability (1992) Chapter: Screening for Cancer. ... The Second Fifty Years: Promoting Health and Preventing Disability. Washington, DC: The National Academies Press. doi: 10.17226 ... The Second Fifty Years: Promoting Health and Preventing Disability. Washington, DC: The National Academies Press. doi: 10.17226 ...
Trial to Promote Recovery From COVID-19 With Ivermectin or Endocrine Therapy - Full Text View - ClinicalTrials.gov
Cachexia (BMI ,18) or hypoalbuminemia (serum albumin ≤3 g/dL). *Ophthalmologic disorder (moderate to severe retina or optic ... Trial to Promote Recovery From COVID-19 With Ivermectin or Endocrine Therapy (RECOVER). The safety and scientific validity of ... A Phase II Trial to Promote Recovery From COVID-19 With Ivermectin or Endocrine Therapy. ...
"MYOGENIC AND ATROPHIC SIGNALING IN THE PROGRESSION OF CANCER-CACHEXIA" by TA Blackwell, JL Brown et al.
Whereas classic catabolic factors are not impacted until later in progression of cancer-cachexia. MyoD seems to promote ... Severe weight and muscle loss (cancer-cachexia) is accepted as a common side effect of most cancer, and is estimated to be ... The mechanisms that control the development of cancer-cachexia are not well understood. In order for muscle wasting to occur, ... Most investigations of cancer-cachexia focus on the post-cachectic state and do not examine the progression of the condition. ...
Triclosan impairs excitation-contraction coupling and Ca2+ dynamics in striated muscle | PNAS
... promoting fatigue, sarcopenia, or cachexia, a conclusion verified in grip-strength measurements made following acute exposure ... A prominent comorbidity of heart failure with poor prognosis is cachexia (37). TCS-mediated ECC failure could promote adverse ... Prolonged increases in cytosolic Ca2+ have been shown to promote contractile fatigue in adult skinned muscle fibers and ECC ... alteration in ECC by TCS may promote acute or long-term impacts on muscle health in human populations and environmentally ...
Dietary supplementation with n-3 PUFA does not promote weight loss when combined with a very-low-energy diet | British Journal...
Dietary supplementation with n-3 PUFA does not promote weight loss when combined with a very-low-energy diet - Volume 108 Issue ... 31Colomer, R, Moreno-Nogueira, JM, Garcia-Luna, PP, et al. (2007) N-3 fatty acids, cancer and cachexia: a systematic review of ... Dietary supplementation with n-3 PUFA does not promote weight loss when combined with a very-low-energy diet. * Irene A. Munro ... Dietary supplementation with n-3 PUFA does not promote weight loss when combined with a very-low-energy diet ...
JCI - Volume 123, Issue 11
NF-κB-mediated Pax7 dysregulation in the muscle microenvironment promotes cancer cachexia. ... NF-κB-mediated Pax7 dysregulation in the muscle microenvironment promotes cancer cachexia. ... mutations promote myeloid transformation, a large subset of ASXL1. mutations is thought to result in stable truncation of ASXL1 ... In tumor-bearing mice and patients with pancreatic cancer, we found that cachexia was associated with a type of muscle damage ...
JCI - Brown and beige fat in humans: thermogenic adipocytes that control energy and glucose homeostasis
Cancer cachexia. Cachexia is characterized by severe weight loss, chronic inflammation, and muscle/adipose atrophy. Cancer ... Ablation of LGR4 promotes energy expenditure by driving white-to-brown fat switch. Nat Cell Biol. 2013;15(12):1455-1463.. View ... A switch from white to brown fat increases energy expenditure in cancer-associated cachexia. Cell Metab. 2014;20(3):433-447. ... Inhibition of Notch signaling promotes browning of white adipose tissue and ameliorates obesity. Nat Med. 2014;20(8):911-918. ...
Piperidine, pyrrolidine and hexahydro-1H-azepines promote release of growth hormone - Merck & Co., Inc.
... cachexia and protein loss due to chronic illness such as AIDS or cancer; and treating patients recovering from major surgery, ... BENZO-FUSED LACTAMS PROMOTE RELEASE OF GROWTH HORMONE. WO1994008583A1. 1994-04-28. BENZO-FUSED LACTAMS PROMOTE RELEASE OF ... These compounds promote the release of growth hormone in humans and animals. This property can be utilized to promote the ... Benzo-fused lactams promote release of growth hormone. 1994-02-08. Chu et al.. 514/183. ...
Gladstone Scientists Find Increased ApoE Protein Levels May Promote Alzheimer's Disease - Healthcanal.com : Healthcanal.com
Dermcidin - Wikipedia
A glycosylated form of the N-terminal peptide may be associated with cachexia (muscle wasting) in cancer patients. ... The N-terminal peptide, also known as diffusible survival evasion peptide, promotes neural cell survival under conditions of ... 1998). "Identification of a survival-promoting peptide in medium conditioned by oxidatively stressed cell lines of nervous ... "Characterization of a human homologue of proteolysis-inducing factor and its role in cancer cachexia". Clin. Cancer Res. 10 (17 ...
Oral nitrate supplementation to enhance pulmonary rehabilitation in COPD: ON-EPIC a multicentre, double-blind, placebo...
Skeletal muscleDevelopment of cancer-cachexiaAbstractAdiposeSuffer from cachexiaClinicalMetabolicCause of cancer cacheCytokinesAnorexiaInduceInflammationMiceMechanismsPatientsChronicMorbidity and mortaMultifactorialFeatures of cachexiaContribute to cachexiaTreatment for cachexiaProgressionMuscle atrophyCaloric intakeMitogen-activaPoor prognosisMalnutritionWeightTumorsProtein degradationComplex syndromeMetabolismTherapeuticCatabolicAssociated with increased mortalityInflammatory2000Invasion and metastasisFearonDiffusible survival evasion peptideSurvivalSystemic
- Cachexia is a multifactorial process of skeletal muscle and adipose tissue atrophy resulting in progressive weight loss. (hindawi.com)
- Indeed, evidence suggests that non-muscle tissues and organs, as well as tumour tissues, secrete soluble factors that act on skeletal muscle to promote wasting. (nature.com)
- We need to unravel the communication between skeletal muscle and other tissues to better understand the aetiology of cancer cachexia. (nature.com)
- JAK/STAT3 pathway inhibition blocks skeletal muscle wasting downstream of IL-6 and in experimental cancer cachexia. (nature.com)
- Loss of body weight, wasting of both adipose tissue and skeletal muscle and reduced survival rates are among the main features of cachexia. (frontiersin.org)
- Progressive weight loss combined with skeletal muscle atrophy, termed cachexia, is a common comorbidity associated with cancer that results in adverse consequences for the patient related to decreased chemotherapy responsiveness and increased mortality. (frontiersin.org)
- 1 ) as a novel specific autocrine/endocrine negative regulator of skeletal muscle mass, since its embryonary deletion promoted a large increase in muscle mass as a result of hyperplasia and hypertrophy. (scielo.br)
- Studying how this balance is maintained normally and how it is disrupted in disease conditions will be crucial for understanding and developing treatment regimes for skeletal muscle cachexia. (biologists.org)
- Currently, there are no efficient treatments that specifically target skeletal muscle cachexia, although drugs such as steroids that increase appetite can be administered, but with limited success on reducing muscle wasting. (biologists.org)
- Since insulin in the skeletal muscle inhibits protein degradation and promotes protein synthesis, insulin resistance could be a possible cause of cancer cachexia. (nih.gov)
- however, a loss in oxidative metabolism in skeletal muscle is apparent in cancer-cachexia. (wku.edu)
- PURPOSE: To examine oxidative phenotype of skeletal muscle in tumor bearing mice in cancer-cachexia. (wku.edu)
- CONCLUSION: LLC in mice may promote a cellular energy crisis induced by a decrease in skeletal muscle oxidative phenotype likely tied to a loss in muscle mitochondrial content. (wku.edu)
- The cancer anorexia cachexia syndrome is a systemic metabolic disorder characterized by the catabolism of stored nutrients in skeletal muscle and adipose tissue that is particularly prevalent in nonsmall cell lung cancer (NSCLC). (readbyqxmd.com)
- Despite the fact that metformin can decrease insulin levels and tumour's cell proliferation [ 14 ], few studies analyse metformin action on skeletal muscle in cachexia models. (biomedcentral.com)
- Mechanisms of Skeletal Muscle Degradation and its Therapy in Cancer Cachexia. (cityofhope.org)
- 1 Sarcopenia, a gradual loss of skeletal muscle mass and function with age, and cachexia, weight loss due to an underlying illness, are the two most common muscle wasting disorders and represent important syndromes impacting quality and quantity of life in the geriatric population. (rsc.org)
- Up to 50% of cancer patients suffer from cachexia, defined as progressive atrophy of adipose tissue and skeletal muscle. (bioscience.org)
- In addition, cancer cachexia leads to specific loss of skeletal muscle, 75% of which may be depleted just prior to death, while visceral proteins are preserved and may even increase (9). (bioscience.org)
- Cancer cachexia is a multifactorial syndrome characterised by an ongoing loss of skeletal muscle mass that cannot be fully reversed by conventional nutritional support alone. (ovid.com)
Development of cancer-cachexia2
- Insulin resistance and body composition in cancer patients Dev, R;Bruera, E;Dalal, S 2018-02-01 00:00:00 Abstract Cancer cachexia, weight loss with altered body composition, is a multifactorial syndrome propagated by symptoms that impair caloric intake, tumor byproducts, chronic inflammation, altered metabolism, and hormonal abnormalities. (deepdyve.com)
- Energy wasting in cachexia is caused by excessive lipid and protein turnover in the body, browning of white adipose tissue (WAT), and futile metabolic cycling such as glucose recycling between the liver and tumor. (aacrjournals.org)
- Cachexia in cancer is characterized by loss of body weight and muscle and by adipose tissue wasting and systemic inflammation. (nature.com)
- The importance of the metabolic changes that occurr in white and brown adipose tissues during cancer cachexia have been underestimated. (nature.com)
- Moreover, progestagens, the only drugs approved by FDA for cancer-related cachexia, can only increase adipose tissue and have not been confirmed to augment lean body mass. (jcancer.org)
- Exercise Training Promotes Sex-Specific Adaptations in Mouse Inguinal White Adipose Tissue. (harvard.edu)
- Cancer cachexia thus differs from simple starvation, in which more than three-quarters of body weight loss is due to loss of adipose mass, and only a small amount due to loss of muscle mass. (bioscience.org)
- Cancer cachexia results in altered body composition with the loss of lean muscle mass with or without the loss of adipose tissue. (deepdyve.com)
- Alteration in visceral adiposity, accumulation of intramuscular adipose tissue, and secretion of adipocytokines from adipose cells may play a role in promoting the metabolic derangements associated with cachexia including a proinflammatory environment and insulin resistance. (deepdyve.com)
- cancer cachexia, insulin resistance, body composition Key Message Cancer cachexia is a multifactorial syndrome characterized by impaired caloric intake, chronic inflammation and altered metabolism resulting in loss of lean muscle mass with or without loss of adipose tissue. (deepdyve.com)
- During physical exercise, inflammatory status is elevated due to muscle production of pro-inflammatory cytokines, which promote fatty acid mobilization from adipose tissue to meet the muscle energy demand. (xxmu.edu.cn)
Suffer from cachexia2
- Inconsistencies in the definition of cachexia have limited the epidemiological characterisation of the condition and there has been slow progress in identifying therapeutic agents and trialling them in the clinical setting. (hindawi.com)
- The prominent clinical feature of cachexia is weight loss in adults (corrected for fluid retention) or growth failure in children (excluding endocrine disorders). (hindawi.com)
- Exercise training is currently recommended for the clinical management of low-grade inflammatory conditions as cancer cachexia. (elsevier.es)
- Thus, CRP levels, in combination with reduced food intake and weight loss, could be used as a clinical marker of cancer cachexia. (hindawi.com)
- Based on basic and clinical research, glucose intolerance and insulin resistance have been postulated to be associated with cancer cachexia. (nih.gov)
- A new study shows that cancer cachexia, which causes life-threatening loss of body weight and lean muscle mass, is caused in part by the tumor factors that block muscle repair, according to the research published in the Journal of Clinical Investigation ( 2013;123:4821-4835 ). (lww.com)
- The adjusted and extended definitions of sarcopenia promote the clinical use of the concept. (diva-portal.org)
- Studies were included in the review if they assessed oral EPA compared with placebo or control in randomised controlled trials of patients with advanced cancer and either a clinical diagnosis of cachexia or self-reported weight loss of 5% or more. (cochrane.org)
- A literature search of clinical trials using the medical subject heading (MeSH) terms 'cachexia' OR 'anorexia' OR 'weight' OR 'frail (truncated)' OR 'appetite' OR 'wasting syndrome' PLUS 'megestrol acetate' OR 'medroxyprogesterone acetate' was performed. (bmj.com)
- Here, we review the literature on the mechanisms of cancer cachexia and the pharmacological interventions both in use in clinical practice and currently under development. (bioscience.org)
- Over the past several years, research has helped elucidate the mechanisms behind cancer cachexia, and several pharmacologic agents that may reverse the syndrome are now available in clinical practice or under development. (bioscience.org)
- The clinical phenotype of cachexia ranges from minimal or no weight loss with signs of muscle wasting to severe weight loss with signs of muscle depletion, fatigue, and reduced mobility. (humankinetics.com)
- Systemic inflammation is a hallmark of patients with cancer, and the inflammatory response is involved in the metabolic alterations present during cancer cachexia. (nature.com)
- Taken together, these results suggest that cancer cell-derived cytokines, such as IL-1α, induce cachexia by affecting leptin-dependent metabolic pathways. (elsevier.com)
- Similarly, cancer cachexia is a complex wasting syndrome comprising inflammatory and metabolic disturbances ( 2 ). (aacrjournals.org)
- Cachexia is likely mediated by neuroendocrine, metabolic, and inflammatory pathways [ 13 , 14 ], and the criteria used to define cachexia vary widely. (prolekare.cz)
- Uncontrolled inflammation in cachexia can lead to an elevated resting metabolic rate, further increasing the demands for protein and energy sources. (wikipedia.org)
- 40-80% of cancer patients have significant weight loss due to metabolic changes and cachexia, which comes from the Greek kachexia meaning bad condition. (cancersupportivecare.com)
- Cachexia is a syndrome of weight loss characterised by decreased muscle mass in the presence of the metabolic effects of an underlying illness such as some types of cancer or advanced heart failure. (bmj.com)
- In 2008, the Cachexia Consensus Working Group published a proposal for the following definition: 'Cachexia, is a complex metabolic syndrome associated with underlying illness and characterized by loss of muscle with or without loss of fat mass'. 8 Within this publication, a set of diagnosis criteria were proposed. (bmj.com)
- Expert consensus definition of cancer cachexia highlights metabolic abnormalities resulting in altered glucose, lipid, and protein metabolism . (deepdyve.com)
- Cachexia is characterized by increased muscle protein degradation, elevated basal metabolic rate and total energy expenditure, and either no change or reduction in FM . (deepdyve.com)
Cause of cancer cache1
- Therefore, mitochondria degeneration in muscle cells may be an underlying cause of cancer-cachexia that ultimately leads to patient death. (wku.edu)
- Animals implanted with MCF-7IL-1α cells were cachetic, which correlated with increased leptin serum levels but not other known cachexia-inducing cytokines such as IL-6, tumor necrosis factor, or interferon gamma. (elsevier.com)
- Cancer-induced pain and cachexia are often studied and treated independently, although both symptoms are strongly linked with chronic inflammation and sustained production of proinflammatory cytokines. (aacrjournals.org)
- Proinflammatory cytokines including TNF-α and interleukin-6 (IL-6) have been shown to induce cachexia by altering metabolism of lipids and muscle proteins ( 2 , 22 , 23 ). (aacrjournals.org)
- Sharma R, Anker SD (2002) Cytokines, apoptosis and cachexia:the potential for TNF antagonism. (springer.com)
- In addition, proinflammatory cytokines such as TNFα and IL-6 have also been suggested to promote cancer cachexia ( Tisdale, 2009 ). (biologists.org)
- Combination of inflammation-related cytokines promotes long-term muscle stem cell expansion. (sibcb.ac.cn)
- While increases in circulating levels of a number of inflammatory cytokines have been associated with cancer cachexia, these associations were generally made in patients with advanced disease and thus may be associated with disease progression rather than directly with the cachexia syndrome. (readbyqxmd.com)
- Although many different tissues and cell types may be responsible for the increase in circulating cytokines, evidence indicates tumors themselves are an important source of factors that may promote cachexia in cancer. (wikipedia.org)
- Pro-inflammatory cytokines involves in energy regulation in several conditions, such as obesity, aging (calorie restriction), sports (exercise), and cancer (cachexia). (xxmu.edu.cn)
- Cachexia is compounded by anorexia and the relationship between these two entities has not been clarified fully. (hindawi.com)
- Anorexia, inflammation, insulin resistance, and increased muscle protein breakdown are frequently associated with cachexia [ 6 ]. (hindawi.com)
- Cancer cachexia is often associated with anorexia and increased energy expenditure. (nature.com)
- Cancer cachexia is an energy-wasting syndrome caused by decreased food intake (owing to marked anorexia) and increased energy expenditure. (nature.com)
- Inui A (2002) Cancer anorexia-cachexia syndrome: current issues in research and management. (springer.com)
- Uomo G, Gallucci F, Rabitti PG: Anorexia-cachexia syndrome in pancreatic cancer: recent development in research and management. (springer.com)
- Walker PK: The anorexia-cachexia syndrome. (springer.com)
- Berenstein EG, Ortiz Z: Megestreol acetate for the treatment of anorexia-cachexia syndrome. (springer.com)
- Background Cachexia describes a complex pathological syndrome of muscle wasting, anorexia and weight loss. (bmj.com)
- Terminology remains variable with syndromes such as 'anorexia-cachexia syndrome' and 'wasting syndrome' used synonymously. (bmj.com)
- Johnen H, Lin S, Kuffner T et al (2007) Tumour-induced anorexia/cachexia is mediated by the TGF-b superfamily cytokine MIC-1. (springer.com)
- Oliff A, Defeo-Jones D, Boyer M et al (1987) Tumors secreting human TNF/cachectin induce cachexia in mice. (springer.com)
- Tumor-derived molecules such as lipid mobilizing factor, proteolysis-inducing factor, and mitochondrial uncoupling proteins may induce protein degradation and contribute to cachexia. (wikipedia.org)
- Cancer may induce weight loss and cachexia, and cancer treatment may contribute to nutritional impairment. (bioscience.org)
- For example, many inflammatory diseases including cancer, AIDS, sepsis, diabetes, and congestive heart failure induce debilitating muscle atrophy or wasting due to loss of muscle mass (cachexia). (uth.edu)
- The pathogenesis of cancer cachexia is a complex phenomenon that includes nutritional changes, hypoanabolism, the onset of an overall hypercatabolic response that mainly affects proteins and lipids, chronic inflammation and altered energy metabolism. (frontiersin.org)
- Sarcopenia and cancer cachexia involve excessive and prolonged inflammation that can cause further damage to tissues and organs, including increased muscle protein breakdown and lower muscle protein synthesis. (dsm.com)
- In conditions like sarcopenia and cancer cachexia, EPA and DHA target and reduce the low-grade inflammation that contributes to the development of the disease. (dsm.com)
- Obesity induces inflammation, which is carcinogenic, and also clearly promotes progression of many cancers. (ascopost.com)
- Insulin resistance due to tumor byproducts, chronic inflammation, altered body composition, and endocrine dysfunction may contribute to the development of cachexia in cancer patients and treatment may be warranted to prevent weight loss. (deepdyve.com)
- Termed the MENAC trial (Multimodal-Exercise, Nutrition and Anti-inflammatory medication for Cachexia), this intervention is based on evidence to date and consists of non-steroidal anti-inflammatory drugs and eicosapentaenoic acid to reduce inflammation, a physical exercise programme using resistance and aerobic training to increase anabolism, as well as dietary counselling and oral nutritional supplements to promote energy and protein balance. (ovid.com)
- In cancer cachexia, chronic inflammation is elevated by the immune response in the fight against cancer. (xxmu.edu.cn)
- In contrast, super-induction of the inflammation activity leads to weight loss and malnutrition in cancer cachexia. (xxmu.edu.cn)
- We thought a straightforward relationship existed between apoE protein levels and Ab, and that boosting apoE levels in these mice would promote - not halt - the build-up of Ab," explained Gladstone Postdoctoral Fellow and lead author Nga Bien-Ly, PhD. (healthcanal.com)
- Moreover, several pathways leading to cachexia have been well characterized in mice (discussed below). (biologists.org)
- Finally, the availability of mice carrying mutations in genes that are associated with cachexia make mice an optimal model organism for investigating this condition. (biologists.org)
- When you inject that agent [prohibitin-TP01] into mice, it hones in on and promotes the death of blood vessels associated with white fat tissue, which is then reabsorbed and metabolized. (ascopost.com)
- 2015) Macrophage Inhibitory Cytokine-1 ( MIC-1/GDF15 ) Gene Deletion Promotes Cancer Growth in TRAMP Prostate Cancer Prone Mice. (springer.com)
- ZIP4 Promotes Muscle Wasting and Cachexia in Mice with Orthotopic Pancreatic Tumors by Stimulating RAB27B-Regulated Release of Extracellular Vesicles From Cancer Cells. (uth.edu)
- Researchers headed by Antonio Zorzano at IRB demonstrate that the DOR protein promotes muscle mass loss in mice. (irbbarcelona.org)
- Follistatin gene delivery promoted insulinemia and abundance of insulin-positive pancreatic ß-cells, even when treatment was administered to mice with advanced diabetes, supporting a mechanism for improved glycemic control associated with maintenance of functional ß-cells. (bvsalud.org)
- However, whether ZAG plays any role beyond lipolysis and participates in other energy wasting mechanisms of cachexia such as glucose and lipid recycling, and WAT browning has not been explored. (aacrjournals.org)
- NGF might be a molecule common to the mechanisms responsible for clinically distinctive cancer symptoms such as pain and cachexia as well as cancer progression. (aacrjournals.org)
- Although this muscle wasting might be a product of enhanced protein degradation, the precise mechanisms of cancer cachexia are not fully elucidated. (nih.gov)
- Cancer cachexia is a complex condition of tissue wasting that affects up to 80% of cancer patients. (aacrjournals.org)
- Therefore, identifying and inhibiting factors that promote WAT browning, and glucose and lipid recycling can reduce energy wasting and ameliorate cachexia in cancer patients. (aacrjournals.org)
- These findings suggest that ZAG plays a predominant role in the development of cachexia, and thus, may represent a novel therapeutic target to block energy wasting and delay or prevent cachexia in cancer patients. (aacrjournals.org)
- Cachexia correlates with poor performance status, poor quality of life, and a high mortality rate in cancer patients [ 2 ]. (hindawi.com)
- Cachexia among US cancer patients. (nature.com)
- The management of cancer patients is frequently complicated by the occurrence of cachexia. (frontiersin.org)
- Cachexia affects the majority of patients with advanced cancer and no effective treatment is currently available to address this paraneoplastic syndrome. (elsevier.es)
- As an example, high circulating levels of C-reactive protein (CRP) are frequently observed in cancer patients with cachexia. (hindawi.com)
- Pain and cachexia significantly impair function and degrade quality of life in patients suffering from cancer ( 1-7 ). (aacrjournals.org)
- Wigmore SJ, Ross JA, Falconer JS et al (1996) The effect of polyunsaturated fatty acids on the progress of cachexia in patients with pancreatic cancer. (springer.com)
- Circulating monocyte chemoattractant protein-1 (MCP-1) is associated with cachexia in treatment-naïve pancreatic cancer patients. (nih.gov)
- A glycosylated form of the N-terminal peptide may be associated with cachexia (muscle wasting) in cancer patients. (wikipedia.org)
- If low BMI is associated with mortality after AMI independent of other conditions and function, then promoting weight gain and optimizing caloric intake in underweight patients after AMI may improve outcomes, a hypothesis that could be tested. (prolekare.cz)
- We posed two questions: (1) does comprehensive risk adjustment for comorbid illness and frailty measures explain the higher mortality after AMI in underweight patients, and (2) is the relationship between underweight and mortality also observed in patients with AMI who are otherwise without significant chronic illness and are presumably free of cachexia? (prolekare.cz)
- Systemic manifestations include frequent symptoms in pancreatic cancer patients, such as fever and cachexia. (springer.com)
- Bruera E, Sweeney C: Cachexia and asthenia in cancer patients. (springer.com)
- For the study the researchers analyzed animal models and tissue from cachectic pancreatic cancer patients to identify the factor in the muscle microenvironment that contributes to cancer cachexia. (lww.com)
- It is also used to stimulate appetite and to promote weight gain in cachexia patients. (thefreedictionary.com)
- Increasing life expectancy worldwide has an impact on the prevalence of age- and lifestyle-related non-communicable diseases (NCDs), contributing to a rise in the number of patients presenting with conditions including cancer cachexia and sarcopenia. (dsm.com)
- In our latest ask-the-expert interview, DSM's Nutrition Science & Advocacy Lead Scientist, Dr. Barbara Troesch, discusses the key aspects to consider when developing effective and targeted medical nutrition solutions that meet the specific and complex nutritional requirements of patients with cancer cachexia and sarcopenia. (dsm.com)
- 4 Cancer cachexia is a prevalent condition in cancer patients that have malignant tumor growth, associated with extreme weight loss and wasting of the body, as well as decreased ability to fight infection and withstand cancer treatment. (dsm.com)
- Comparisons of EPA combined with a protein energy supplementation versus a protein energy supplementation (without EPA) in the presence of an appetite stimulant (Megestrol Acetate) provided no evidence that EPA improves symptoms associated with the cachexia syndrome often seen in patients with advanced cancer. (cochrane.org)
- Cancer cachexia is a distressing weight loss syndrome commonly seen in advanced cancer patients. (cochrane.org)
- Eicosapentaenoic acid (EPA) is a long chain polyunsaturated fatty acid found naturally in some fish which has been used to decrease weight loss, promote weight gain and increase survival times in patients affected with cancer cachexia. (cochrane.org)
- To evaluate the effectiveness and safety of EPA in relieving symptoms associated with the cachexia syndrome in patients with advanced cancer. (cochrane.org)
- Cancer-associated wasting, termed cancer cachexia, has a profound effect on the morbidity and mortality of cancer patients but remains difficult to recognize and diagnose. (readbyqxmd.com)
- Thus, we sought to assess potential biomarkers of cancer-induced cachexia in patients with earlier stages of disease. (readbyqxmd.com)
- Cancer is one of the leading causes of deaths worldwide [ 1 ], and many cancer patients show malnutrition and weight loss due to tumour-associated catabolic stress, developing cancer-cachexia state. (biomedcentral.com)
- Prevalence of cachexia rises in more advanced stages and is estimated to affect 80% of terminal cancer patients. (wikipedia.org)
- Medical Xpress) -- Cachexia, a syndrome characterized by rapid weight loss and muscle deterioration, is a major cause of death among patients suffering from diseases like cancer, AIDS and chronic infection. (medicalxpress.com)
- To this day, when patients are diagnosed with cachexia, they re sent to palliative care. (medicalxpress.com)
- L-carnitine is also administered in the form of supplements to cure involuntary weight loss and increase the body mass index (BMI) in patients with cachexia or wasting syndrome. (globenewswire.com)
- http://www.ncbi.nlm.nih.gov/pubmed/18718696?tool=bestpractice.com While all patients with cachexia have unintentional weight loss, not all patients with unintentional weight loss have cachexia. (bmj.com)
- This collated results from 916 patients with HIV/AIDS, end-stage renal failure, chronic obstructive pulmonary disease (COPD) and geriatric cachexia. (bmj.com)
- Cachexia is common in patients with advanced chronic disease with an estimated 25% of patients with chronic obstructive pulmonary disease (COPD) and 25-50% of patients with end-stage renal failure (ESRF) suffering from this syndrome. (bmj.com)
- Such evaluation is particularly important when considering the data regarding the association among weight loss, cancer cachexia, and poor outcomes in cancer patients. (bioscience.org)
- Cachexia is associated with reduced performance status, decreased tolerance to chemotherapy, and increased mortality in cancer patients. (deepdyve.com)
- The scientists hypothesize that the design of an inhibitor against DOR would serve to prevent and tackle muscle wasting in patients suffering from sarcopenia and cachexia. (irbbarcelona.org)
- Several published studies have reported that many patients with cancer-related cachexia are often low in carnitine, and daily supplementation is associated with reduced fatigue and increased lean body mass. (lifeextension.com)
- And cachexia (severe weight loss) is a very common problem among cancer patients. (mumc.nl)
- In patients with chronic HF and cardiac cachexia, the increment of this protein levels might be related to inflammatory response caused by injury [ 13 ] [ 15 ]. (medsci.org)
- Cachexia is a complex syndrome frequently present in patients with chronic severe illnesses, including COPD, cancer, and congestive heart failure. (humankinetics.com)
- The prognostic significance of weight loss in chronic obstructive pulmonary disease-related cachexia: a prospective cohort study. (nih.gov)
- Cachexia is a common term for the wasting symptoms which may appear in almost every chronic illness, such as AIDS, tuberculosis, and cancer. (jcancer.org)
- A range of diseases can cause cachexia, most commonly cancer, congestive heart failure, chronic obstructive pulmonary disease, chronic kidney disease and AIDS. (wikipedia.org)
- Congestive heart failure, AIDS, chronic obstructive pulmonary disease, and chronic kidney disease are other conditions that often cause cachexia. (wikipedia.org)
Morbidity and morta1
- Cachexia has a high prevalence in cancer and a major impact on patient physical function, morbidity and mortality. (ovid.com)
- The exact mechanism in which these diseases cause cachexia is poorly understood, and likely is multifactorial with multiple disease pathways involved. (wikipedia.org)
- It has been argued that the multifactorial genesis of cachexia lends itself to therapeutic targeting through a multimodal treatment. (ovid.com)
Features of cachexia1
- Diagnostic guidelines and criteria have only recently been proposed despite the prevalence of cachexia and varying criteria, the primary features of cachexia include progressive depletion of muscle and fat mass, reduced food intake, abnormal metabolism of carbohydrate, protein, and fat, reduced quality of life, and increased physical impairment. (wikipedia.org)
Contribute to cachexia1
- Further cell-based and in vivo studies are need to ascertain whether factors identified in this study that were found to contribute to cachexia can be targeted for therapy. (lww.com)
Treatment for cachexia2
- Most investigations of cancer-cachexia focus on the post-cachectic state and do not examine the progression of the condition. (wku.edu)
- Whereas classic catabolic factors are not impacted until later in progression of cancer-cachexia. (wku.edu)
- Abnormal tumor vasculature creates hypoxic pockets which promote cancer progression and further increase the glycolytic-dependency of cancers. (plos.org)
- My lab has discovered that stromal cells in fat tissue become mobilized, migrate to the tumor microenvironment, and become a subpopulation of fibroblasts that promote cancer progression to chemotherapy resistance. (ascopost.com)
- Stimuli such as exercise or steroids can shift this balance towards muscle hypertrophy, whereas muscle disuse or disease states such as cachexia can cause muscle atrophy. (biologists.org)
- Previous studies demonstrated that signaling through the activin receptor is crucial for regulating muscle atrophy-hypertrophy balance, with increased signaling being thought to promote cachexia. (biologists.org)
- In contrast to weight loss from inadequate caloric intake, cachexia causes mostly muscle loss instead of fat loss. (wikipedia.org)
- Here, using the melanoma lineage survival oncogene MITF as a model, we show that low-affinity binding sites act as a competitive reservoir in vivo from which transcription factors are released by mitogen-activated protein kinase (MAPK)-stimulated acetylation to promote increased occupancy of their regulatory elements. (bvsalud.org)
- The etymology of the word cachexia points to its association with poor prognosis: it is derived from the Greek kakos and hexia -"bad condition" and has long been recognised as a key sign in many cancers. (hindawi.com)
- Overall, we found that lncRNA PCNAP1 predicted a poor prognosis in breast cancer and promoted cancer metastasis via miR‑340‑5p‑dependent upregulation of SOX4 expression. (spandidos-publications.com)
- In severe cases, malnutrition can progress to cachexia, a specific form of malnutrition characterized by loss of lean body mass and muscle wasting. (nih.gov)
- Cancer cachexia (CCA) is a result of the interaction between the host and the tumor, mainly manifested in short-term wasting, malnutrition, and so on. (jcancer.org)
- Loss of greater than 5-10% of body weight is usually taken as a defining point for cachexia, although the physiological changes may be present long before this cutoff point is reached. (hindawi.com)
- Severe weight and muscle loss (cancer-cachexia) is accepted as a common side effect of most cancer, and is estimated to be responsible for 20-40% of cancer-related deaths. (wku.edu)
- More recently, novel approaches have included the use of oral fish oils that can contain the omega-3 fatty acid eicosapentaenoic acid (or EPA) to stabilise weight loss and promote weight gain. (cochrane.org)
- In the attempt to include a broader evaluation of the burden of cachexia, diagnostic criteria using assessments of laboratory metrics and symptoms in addition to weight have been proposed. (wikipedia.org)
- Furthermore, the benefits of L-carnitine in improving endurance, weight management, and promoting efficient conversion of food into energy are encouraging its consumption. (globenewswire.com)
- Cachexia not only results in weight loss and reduced quality of life and survival but is also the direct cause of up to 20% of all cancer deaths due to immobility and cardiac/respiratory failure (6). (bioscience.org)
- Cancer cachexia may be clinically defined as the involuntary loss of more than 5% of pre-morbid weight within a 6-month period (7). (bioscience.org)
- A number of studies have reported that testosterone treatment has been useful in promoting lean weight gain for people with AIDS- or COPD-related cachexia, and can improve protein synthesis and muscle mass in men and women. (lifeextension.com)
- Animal studies suggest that omega-3 fatty acids may prevent or reduce cancer-related weight loss, appetite loss, and muscle wasting, collectively known as cachexia. (medi-vet.com)
- Animal studies also suggest that omega-3 fatty acids inhibit cachexia (weight loss), which is significant because one way that cancer kills is by starving the pet. (medi-vet.com)
- On the other hand, innate immune cells, such as neutrophils and macrophages, have been frequently shown to infiltrate tumors and promote an immunosuppressive environment. (pnas.org)
- Hyperbaric oxygen therapy (HBO 2 T) saturates tumors with oxygen, reversing the cancer promoting effects of tumor hypoxia. (plos.org)
- Cachexia (/kəˈkɛksiə/) is a complex syndrome associated with an underlying illness causing ongoing muscle loss that is not entirely reversed with nutritional supplementation. (wikipedia.org)
- In this Review, we examine the effect of non-muscle tissues and inter-tissue communication in cancer cachexia and discuss studies aimed at developing novel therapeutic strategies for the condition. (nature.com)
- The term catabolic wasting encompasses both cachexia and sarcopenia. (lifeextension.com)
Associated with increased mortality2
- An acute inflammatory response is a controlled process, with a short time window of minutes up to a few hours and it is characterized by the abundant presence of a specific type of immune competent cells (neutrophils), responsible for clearing invading pathogens and promote tissue repair, thus restoring homeostasis. (intechopen.com)
Invasion and metastasis1
- For example, it was found that androgen receptor negatively induced lncRNA (ARNILA) promoted invasion and metastasis in triple-negative BC ( 12 ). (spandidos-publications.com)
Diffusible survival evasion peptide1
- The N-terminal peptide, also known as diffusible survival evasion peptide, promotes neural cell survival under conditions of severe oxidative stress. (wikipedia.org)
- Cachexia is a systemic condition that occurs during many neoplastic diseases, such as cancer. (nature.com)
- There is inherent difficulty to examining the mechanistic drivers of cachexia, namely a large number of disruptions to systemic homeostatic regulation that occur with cancer, the inherent heterogeneity of different cancers, and the patient's underlying health condition. (frontiersin.org)