A phenothiazine derivative with histamine H1-blocking, antimuscarinic, and sedative properties. It is used as an antiallergic, in pruritus, for motion sickness and sedation, and also in animals.
Drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine. Included here are the classical antihistaminics that antagonize or prevent the action of histamine mainly in immediate hypersensitivity. They act in the bronchi, capillaries, and some other smooth muscles, and are used to prevent or allay motion sickness, seasonal rhinitis, and allergic dermatitis and to induce somnolence. The effects of blocking central nervous system H1 receptors are not as well understood.
Disorder characterized by nausea, vomiting, and dizziness, possibly in response to vestibular disorientation or fluid shifts associated with space flight. (From Webster's New World Dictionary)
A traditional grouping of drugs said to have a soothing or calming effect on mood, thought, or behavior. Included here are the ANTI-ANXIETY AGENTS (minor tranquilizers), ANTIMANIC AGENTS, and the ANTIPSYCHOTIC AGENTS (major tranquilizers). These drugs act by different mechanisms and are used for different therapeutic purposes.
Agents, usually topical, that relieve itching (pruritus).
Compounds containing dibenzo-1,4-thiazine. Some of them are neuroactive.
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A feeling of restlessness associated with increased motor activity. This may occur as a manifestation of nervous system drug toxicity or other conditions.
A narcotic analgesic that can be used for the relief of most types of moderate to severe pain, including postoperative pain and the pain of labor. Prolonged use may lead to dependence of the morphine type; withdrawal symptoms appear more rapidly than with morphine and are of shorter duration.
A histamine H1 antagonist. It is used in hypersensitivity reactions, in rhinitis, for pruritus, and in some common cold remedies.
The prototypical phenothiazine antipsychotic drug. Like the other drugs in this class chlorpromazine's antipsychotic actions are thought to be due to long-term adaptation by the brain to blocking DOPAMINE RECEPTORS. Chlorpromazine has several other actions and therapeutic uses, including as an antiemetic and in the treatment of intractable hiccup.

Sequential randomised and double blind trial of promethazine prophylaxis against early anaphylactic reactions to antivenom for bothrops snake bites. (1/126)

OBJECTIVE: To investigate the efficacy of the H1 antihistamine promethazine against early anaphylactic reactions to antivenom. DESIGN: Sequential randomised, double blind, placebo controlled trial. SETTING: Public hospital in a venom research institute, Sao Paulo, Brazil. PARTICIPANTS: 101 patients requiring antivenom treatment after being bitten by bothrops snakes. INTERVENTION: Intramuscular injection of promethazine (25 mg for adults and 0.5/kg for children) or placebo given 15-20 min before starting intravenous infusion of antivenom. MAIN OUTCOME MEASURES: Incidence and severity of anaphylactic reactions occurring within 24 hours after antivenom. RESULTS: Reactions occurred in 12 of 49 patients treated with promethazine (24%) and in 13 of 52 given placebo (25%); most were mild or moderate. Continuous sequential analysis indicated that the study could be interrupted at the 22nd untied pair, without preference for promethazine or placebo. CONCLUSION: Prophylaxis with promethazine does not prevent early reactions. Patients should be observed carefully during antivenom infusion and the subsequent few hours.  (+info)

Comparison of oral chloral hydrate with intramuscular ketamine, meperidine, and promethazine for pediatric sedation--preliminary report. (2/126)

Fifteen consecutive pediatric patients ranging from 3 to 5 years old were selected to receive one of three sedative/hypnotic techniques. Group 1 received oral chloral hydrate 50 mg/kg, and groups 2 and 3 received intramuscular ketamine 2 mg/kg and 3 mg/kg, respectively. In addition to ketamine, patients in groups 2 and 3 received transmucosal intramuscular injections of meperidine and promethazine into the masseter muscle. Sedation for the satisfactory completion of restorative dentistry was obtained for over 40 min on average in the chloral hydrate group, but completion of dental surgery longer than 40 min was achieved in groups 2 and 3 only by intravenous supplements of ketamine.  (+info)

A double-blind, placebo-controlled investigation of the effects of fexofenadine, loratadine and promethazine on cognitive and psychomotor function. (3/126)

AIMS: To assess whether fexofenadine in a range of doses from 80 to 180 mg has any disruptive effects on aspects of psychomotor and cognitive function in comparison with placebo, loratadine and promethazine, an antihistamine known to produce psychomotor and cognitive impairment. METHODS: Twenty-four healthy volunteers received fexofenadine 80 mg, 120 mg and 180 mg, loratadine 10 mg, promethazine 30 mg (as a positive internal control) and placebo in a six-way crossover, double-blind study. Following each dose, subjects were required to perform a series of tests of cognitive function and psychomotor performance at 1.5, 3, 6, 9, 12 and 24 h post dose. The test battery included critical flicker fusion (CFF), choice reaction time (CRT) and assessment of subjective sedation (LARS). Overall levels of activity were monitored by means of wrist mounted actigraphs throughout each of the 24 h experimental periods. RESULTS: Fexofenadine at all doses tested was not statistically different from placebo in any of the tests used and loratadine did not cause any significant impairment of cognitive function. Significant impairments were found following promethazine. Promethazine caused a significant reduction in CFF threshold and this effect was evident up to 12 h post dose (P<0.05). There was a significant increase in recognition reaction time at 3 and 6 h post promethazine administration, and the drug caused a significant (P<0. 002) increase in the percentage of 'sleep-like' activity from actigraph records during the daytime. CONCLUSIONS: Fexofenadine at doses up to 180 mg appears free from disruptive effects on aspects of psychomotor and cognitive function in a study where the psychometric assessments have been shown to be sensitive to impairment, as evidenced by the effects of the verum control promethazine 30 mg.  (+info)

Efficacy of promethazine suppositories dispensed to outpatient surgical patients. (4/126)

Postoperative nausea and vomiting frequently complicate outpatient anesthesia and surgery. The duration of treatment for this complication must occasionally extend beyond discharge from the hospital. In this study, we evaluated the commonly used anti-emetic promethazine for its efficacy in the post-discharge period. Adult outpatient surgical patients who had excessive postoperative nausea and vomiting in the recovery room, or who were at risk for postoperative nausea and vomiting following discharge were given two promethazine suppositories (25 mg) for home use. All patients were contacted by our recovery room nurses on the first business day after their surgery and questioned as to their use of the suppositories and, if used, their efficacy. We found that 55 percent of patients given promethazine suppositories for home use had nausea and vomiting in the post-discharge period. Of the patients given promethazine, 89 percent used the suppositories. All of these patients reported improvement in their symptoms following use of the suppositories. None reported adverse effects from the promethazine suppositories. In conclusion, we found promethazine suppositories to be an inexpensive and efficacious treatment for nausea and vomiting in adult outpatient surgical patients following discharge from the hospital. Side-effects were minimal, and our patients voiced no complaints about this mode of therapy. We recommend this therapy for treatment of nausea and vomiting after hospital discharge following adult outpatient surgery.  (+info)

Metoclopramide and pimozide in Parkinson's disease and levodopa-induced dyskinesias. (5/126)

Metoclopramide is an antiemetic drug which occasionally produced acute dystonic reactions. Although known to interfere with central dopamine mechanisms, it is frequently used in Parkinson's disease to prevent levodopa-induced nausea and vomiting. In this study metoclopramide did not increase Parkinsonism or reduce levodopa-induced involuntary movements in patients with Parkinson's disease. Pimozide, by contrast, increased Parkinsonism and reduced involuntary movements. The capacity of metoclopramide to produce acute dyskinesias while being apparently free of Parkinsonism effects is pharmacologically unique and differentiates this drug from the phenothiazines and butyrophenones.  (+info)

An unusual multiple drug intoxication case involving citalopram. (6/126)

A 47-year-old male with a history of drug abuse and suicide attempts was found dead at home. The death scene investigation showed evidence of cocaine abuse and multiple drug ingestion. Citralopram, a new selective serotonin reuptake inhibitor, cocaine, oxycodone, promethazine, propoxyphene, and norpropoxyphene were identified and quantitated in the postmortem samples by gas chromatography-mass spectrometry. The concentration of citalopram in the femoral blood was 0.88 mg/L. The heart blood concentration was 1.16 mg/L. Femoral blood concentrations of the other drugs were as follows: cocaine, 0.03 mg/L; oxycodone, 0.06 mg/L; promethazine, 0.02 mg/L; propoxyphene, 0.02 mg/L; and norpropoxyphene, 0.07 mg/L. Other tissue samples were also analyzed. The concentrations of cocaine, oxycodone, promethazine, and propoxyphene in the blood, liver, brain, and gastric contents did not suggest an intentional overdose. However, the possibility of multiple drug interactions including citalopram was evident. In this case, the citalopram concentrations were consistent with those reported in fatal cases involving multiple drug use. Citalopram was present in urine at a concentration of 0.9 mg/L.  (+info)

A liquid chromatographic method for the simultaneous determination of promethazine and three of its metabolites in plasma using electrochemical and UV detectors. (7/126)

A new assay method has been developed for the quantitation of promethazine (PMZ) with a sensitivity and reproducibility as good as any previously reported method. This method is also capable of quantitatively determining three metabolites of PMZ (monodemethylated, sulphoxidated, and monodemethylated sulphoxidated PMZ), which has not been previously described. The method uses high-performance liquid chromatography with amperometric and UV detection simultaneously and requires only one extraction step from serum with chloroform. The method uses trifluoperazine as the internal standard. The limit of detection level for PMZ is 1.0 ng/ml when a 0.2-mL specimen of plasma is assayed. A validation study is also conducted for evaluating the recovery, precision, linearity of response, sensitivity, and selectivity of the method.  (+info)

Mechanistic appraisal of the charge-transfer complexes of promethazine with chloranil: a modelling approach. (8/126)

Various mechanisms are often used to explain the interaction between electron donors and acceptors. Commonly proposed mechanisms are those in which the acceptor interacts with the aromatic pi-systems in the donor molecule or the acceptor forms a weak interaction of the Lewis acid with Lewis base type. In this study, the above mechanisms were examined as well as other possible mechanisms. Promethazine was chosen as the model drug containing aromatic systems capable of pi-pi interaction as well as N-methyl group capable of forming a complex with the weak Lewis acid, p-chloranil. Our modelling studies revealed that the situation where the p-chloranil interacts with a protonated N-methyl group is the most significant mechanism of interaction, based on the calculated energies for the highest occupied molecular orbital (HOMO) and the lowest unoccupied molecular orbital (LUMO), the Tripos force field energy terms and also the stability of the complexes during molecular dynamics simulations.  (+info)

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TY - JOUR. T1 - Patch photopatch test at Manipal. AU - Panja, A.. AU - Srinivas, C. R.. AU - Shenoy, S. D.. AU - Balachandran, C.. PY - 1994/12/1. Y1 - 1994/12/1. N2 - Patch and photopatch testing was performed on 55 patients with history of photosensitivity using Scandanavian photo patch test antigens obtained from Chemotechnique Diagnostics AB Sweden. The commonest reactions were seen to perfume mix 4 (21.0%), PABA 3 (15.78%), promethazine hydrochloride 3 (15.78%), chlorpromazine hydrochloride 3 (15.78%), balsam of peru 2 (10.52%), usnic acid, hexachlorophane, musk ambrette and 6 methyl coumarin showed 1 positive reaction each (5.26%) suggesting either phototoxicity or photo sensitization. Patch and photo patch test positive reaction suggesting allergic sensitisation was seen to balsam of peru 3 (23.0%) perfume mix 3 (23.0%) promethazine hydrochloride 2 (15.3%) and PABA, 6 methyl coumarin, tribromosalicylanilide, atranorin and wood mix showed positive reaction in one case each (7.69%). We ...
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Abstract The objective of present study was to develop effervescent tablets of promethazine (PMZ) for the treatment of emesis. Effervescent tablets were prepared by direct compression method and were optimized using 32 full factorial design. Amount to sodium starch glycolate(X1) and amount of sodium bicarbonate (X2) were selected as independent variables, whereas disintegration time (Y1), amount of carbon dioxide (Y2) and drug release in 5 minutes (Y3) were selected as dependent variables. All the batches were also evaluated for general post compression evaluation of tablet such as- weight variation, thickness, friability and hardness. From the results of design batches, best batch was selected and evaluated for in vivo pharmacokinetic study in a rabbit model. The disintegration time ranged from 58.67±0.27sec to 228.67± 0.67sec while amount of carbon dioxide ranged from 0.1±0.082 gm to 0.29±0.061gm in all the design batches. From the results of design batches, batch F9 was selected as ...
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Promethazine Edge ND (September 1953). "The pharmacological differentiation of promethazine hydrochloride (phenergan) from iso- ... promethazine hydrochloride". Archives Internationales De Pharmacodynamie Et De Therapie. 95 (3-4): 428-36. PMID 13125690. v t e ...
Also using promethazine may be useful. Recently, three atypical antipsychotics, olanzapine, aripiprazole and ziprasidone, have ...
Benzydamine Dramamine Promethazine Hubbard, John R.; Martin, Peter R. (2001). Substance Abuse in the Mentally and Physically ...
Huf G, Alexander J, Gandhi P, Allen MH (25 November 2016). "Haloperidol plus promethazine for psychosis-induced aggression". ...
... but haloperidol plus promethazine is preferred due to better effectiveness and due to lorazepam's adverse effects on ... "Haloperidol plus promethazine for psychosis-induced aggression". The Cochrane Database of Systematic Reviews (3): CD005146. doi ...
Promethazine v t e v t e. ...
Promethazine, and subsequently chlorpromazine, were derived from fenethazine. Fenethazine, in turn, was derived from ...
Shi S. J., Platts S. H., Ziegler M. G., Meck J. V. (2011). "Effects of promethazine and midodrine on orthostatic tolerance". ... and/or promethazine to help carry out the tasks they need to do to return home safely. Spaceflight osteopenia is the bone loss ...
Timnak, C.; Gleason, O. (2004). "Promethazine-Induced Psychosis in a 16-Year-Old Girl". Psychosomatics. 45 (1): 89-90. doi: ...
Gerald B Hickson; William A Altemeier; Ellen W Clayton (August 1, 1990). "Should promethazine in liquid form be available ...
Promethazine combined with ephedrine to counteract the sedation is known as "the Coast Guard cocktail". Acupuncture has not ... Other effective first generation antihistamines include meclizine, promethazine, cyclizine, and cinnarizine. In pregnancy ...
"2 Chainz Arrested In LAX For Possession Of Marijuana And Promethazine - XXL". Xxlmag.com. June 11, 2013. Archived from the ... for possession of a controlled substance after TSA agents found that his checked bag contained marijuana and promethazine. He ...
In Canada, promethazine is available as an over the counter anti-histamine by the name of Histantil. As early as the 1950s, ... Promethazine is marketed by the brand name Phenergan for use against allergy symptoms and motion sickness in the US, where a ... Diphenhydramine and promethazine are both marketed by names other than Sominex for several indications including and besides ... In the UK, Actavis UK markets promethazine hydrochloride under the Sominex name. Actavis also markets a product by the name of ...
Brand named as Phenergan with Codeine or in generic form as promethazine with codeine. In the 1990s it started to be mixed with ... But cough syrup containing codeine and promethazine is banned, even with a prescription. The UAE takes an exceptionally strict ... Codeine is also available in conjunction with the anti-nausea medication promethazine in the form of a syrup. ...
Phenothiazine Promethazine Lewis AJ, Dervinis A, Carlson RP, Rosenthale E, Daniel WC (1982). "Thiazinamium chloride: A ... Thus, reaction of the well-known antihistaminic drug promethazine with methylchloride leads to thiazinamium chloride. ...
Promethazine is chemically related to the tranquilizers, and it also has antihistamine properties. It is generally a ...
"promethazine , Activity data visualisation tool , IUPHAR/BPS Guide to PHARMACOLOGY". www.guidetopharmacology.org. Retrieved ...
It also interacts with CYP2B6 substrates such as bupropion, efavirenz, promethazine, selegiline, and sertraline; CYP2C8 ...
This work led to promethazine which had no activity against infective organisms, but did have good antihistamine activity, with ... The derivatives chlorpromazine and promethazine revolutionized the field of psychiatry and allergy treatment, respectively. An ...
The promethazine and codeine concoction first gained popularity in the underground hip hop scene in Houston, where musician Big ... When taken in prescribed quantities, cough syrup is quite safe but dangers arise in higher doses since promethazine is a ... In the 1980s and 1990s the formula changed to using codeine promethazine cough syrup, somewhat like the Glutethimide and ... The Los Angeles County Coroner's Office reported that the rapper's death was "due to promethazine-codeine effects and other ...
These drugs include 6-methylcoumarin, aminobenzoic acid and esters, chlorpromazine, promethazine, diclofenac, sulfonamides, and ...
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Chlorpromazine, derived from promethazine originally as a sedative, was found to have neuroleptic properties in the early 1950s ... Promethazine and other first generation antihistamines with a tricyclic structure were discovered in the 1940s. ...
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Promethazine: learn about side effects, dosage, special precautions, and more on MedlinePlus ... Promethazine comes as a tablet and syrup (liquid) to take by mouth and as a suppository to use rectally.When promethazine is ... When promethazine is used to relieve cold symptoms, it is usually taken every 4 to 6 hours as needed. When promethazine is used ... Promethazine may cause breathing to slow or stop, and may cause death in children. Promethazine should not be given to babies ...
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Promethazine overdose occurs when someone takes too much of this medicine. It is in a class of drugs called phenothiazines, ... Promethazine is a medicine used to treat nausea and vomiting. ... Promethazine is a medicine used to treat nausea and vomiting. ... Promethazine overdose occurs when someone takes too much of this medicine. It is in a class of drugs called phenothiazines, ... Promethazine. In: Aronson JK, ed. Meylers Side Effects of Drugs. 16th ed. Waltham, MA: Elsevier; 2016:972-973. ...
... comes as a tablet and syrup (liquid) to take by mouth and as a suppository to use rectally.When promethazine is ... When promethazine is used to relieve cold symptoms, it is usually taken every 4 to 6 hours as needed. When promethazine is used ... Promethazine may cause breathing to slow or stop, and may cause death in children. Promethazine should not be given to babies ... Promethazine helps control symptoms, but will not treat the cause of the symptoms or speed recovery. Promethazine is in a class ...
Other names: 10H-Phenothiazine-10-ethanamine, N,N,«alpha»-trimethyl-; Phenothiazine, 10-[2-(dimethylamino)propyl]-; Dimapp; Diphergan; Hiberna; Phenargan; Proazamine; Procit; Prothazin; RP 3277; Vallergine; 10-[2-(Dimethylamino)propyl]phenothiazine; (2-Dimethylamino-2-methyl)ethyl-N-dibenzoparathiazine; A-91033; Aprobit; Atosil; Avomine; Dimethylamino-isopropyl-phenthiazin; Diprazine; Diprozin; Fargan; Fenazil; Fenetazina; Histargan; Iergigan; Isophenergan; Lercigan; Lilly 01516; Lilly 1516; N-(2-Dimethylamino-2-methyl)ethylphenothiazine; N-Dimethylamino-2-methylethyl thiodiphenylamine; Phargan; Phensedyl; Pilpophen; Promazinamide; Prometasin; Prometazin; Promethazin; Promezathine; Prorex; Protazine; Provigan; SKF 1498; Tanidil; Thiergan; WY 509; 10-(2-(Dimethylamino)-2-methylethyl)phenothiazine; NCI-C60673; Pyrethiazine; 3277 RP; Phenergan base; (+/-)-Promethazine; Promethiazine; Prometazine ...
Promethazine oral tablet is a prescription drug used to treat several conditions. These include allergies, motion sickness, ... What is promethazine?. Promethazine is a prescription drug. It comes as an oral tablet, an oral solution, an injectable ... Promethazine can cause severe drowsiness. When you take certain pain drugs with promethazine, you may have drowsiness that is ... Promethazine may interact with other medications. Promethazine oral tablet can interact with other medications, vitamins, or ...
Promethazine definition, a phenothiaxine derivative, C 1 7 H 2 0 N 2 S, used for the symptomatic relief of allergies and in the ...
PROMETHAZINE (proe METH a zeen) is an antihistamine. It is used to treat allergic reactions and to treat or prevent nausea and ... Promethazine suppositories. What is this medicine?. PROMETHAZINE (proe METH a zeen) is an antihistamine. It is used to treat ... an unusual or allergic reaction to promethazine or phenothiazines, other medicines, foods, dyes, or preservatives ...
Use of promethazine by injection into a vein is not recommended, due to potential skin damage. Promethazine is in the ... Promethazine is a chiral compound, occurring as a mixture of enantiomers. Promethazine was first synthesized by a group at ... It is unclear if use of promethazine during pregnancy or breastfeeding is safe for the baby. Use of promethazine is not ... Another notable use of promethazine is as a local anesthetic, by blockade of sodium channels. Solid promethazine hydrochloride ...
Collapse after Pethidine and Promethazine. Br Med J 1963; 2 doi: https://doi.org/10.1136/bmj.2.5362.936-b (Published 12 October ...
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Who Should Not Use Promethazine?. Promethazine should not be given to:. •. children under two years of age. •. patients who are ... What Is Promethazine?. Promethazine is an antihistamine which can be taken by mouth as a tablet or syrup, rectally as a ... Promethazine Hydrochloride Tablets, USP This is a summary of the most important information about promethazine. For details, ... Promethazine is metabolized by the liver to a variety of compounds; the sulfoxides of promethazine and N-demethylpromethazine ...
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PROMETHAZINE (KOE deen; fen il EF rin; proe METH a zeen) is a cough suppressant, a decongestant, and an ... Codeine; Phenylephrine; Promethazine oral solution. What is this medicine?. CODEINE; PHENYLEPHRINE; PROMETHAZINE (KOE deen; fen ... an allergic or unusual reaction to codeine, phenylephrine, promethazine, phenothiazines, sulfites, other medicines, foods, dyes ...
Find information on Promethazine (Phenergan) in Daviss Drug Guide including dosage, side effects, interactions, nursing ... promethazine is a topic covered in the Daviss Drug Guide. To view the entire topic, please log in or purchase a subscription. ... "Promethazine." Daviss Drug Guide, 16th ed., F.A. Davis Company, 2020. Washington Manual, www.unboundmedicine.com/ ... washingtonmanual/view/Davis-Drug-Guide/51637/all/promethazine. Vallerand AHA, Sanoski CAC, Quiring CC. Promethazine. Daviss ...
Promethazine is used to treat or prevent nausea and vomiting caused by anesthesia or surgery, certain types of allergic ... Promethazine is in a group of drugs called phenothiazines (FEEN-oh-THYE-a-zeens). It works by changing the actions of chemicals ... What is promethazine injection?. Promethazine is in a group of drugs called phenothiazines (FEEN-oh-THYE-a-zeens). It works by ... Promethazine injection is usually given for only a short time until no longer needed or until you can take promethazine by ...
Read more about the prescription drug PROMETHAZINE/PHENYLEPHRINE - ORAL. ... Consumer information about the medication PROMETHAZINE/PHENYLEPHRINE - ORAL, includes side effects, drug interactions, ... Promethazine is an antihistamine that relieves watery eyes, itchy eyes/nose/throat, runny nose, and sneezing. Phenylephrine is ... GENERIC NAME: PROMETHAZINE/PHENYLEPHRINE - ORAL (pro-METH-uh-zeen/fen-ill-EFF-rin). ...
WebMD provides information about interactions between Phenergan Oral and chlorpromazine-promethazine-meperidine-immediate- ... Meperidine (Immediate Release)/Chlorpromazine; Promethazine Interactions. This information is generalized and not intended as ...
The appearance of Promethazine Hydrochloride can differ based on the dosing. ... PROMETHAZINE HYDROCHLORIDE (injection) comes in different strengths and amounts. ...
Promethazine may increase your risk for convulsions (seizures). It may also cause dystonia (movement disorder). This is more ...
Meperidine and Promethazine - Last updated on October 18, 2020. ©2020 Memorial Sloan Kettering Cancer Center. ... If you have an allergy to meperidine, promethazine, or any other part of this drug. ...
If you have an allergy to codeine, promethazine, or any other part of this drug. ...
Dilated blood vessels can cause nasal congestion (stuffy nose). Promethazine is an antihistamine that reduces the effects of ... What are the possible side effects of phenylephrine and promethazine?. Get emergency medical help if you have any of these ... Promethazine is an antihistamine that reduces the effects of natural chemical histamine in the body. Histamine can produce ... Phenylephrine and promethazine is a combination medicine used to treat sneezing, runny nose, watery eyes, hives, skin rash, ...
I was entranced by an essay in Emergency Physicians Monthly . . . If you want to know what professional craftsmanship looks like, this is it. ". -David Brooks, New York Times Op/Ed Editor. ...
Information about this promethazine-rectal-route. Pregnancy Category. Explanation. All Trimesters. C. Animal studies have shown ... Promethazine is also used to prevent and control motion sickness, nausea, vomiting, and dizziness. In addition, it may be used ... Promethazine is used to relieve or prevent the symptoms of hay fever, allergic conjunctivitis (inflammation of the eye), and ... Appropriate studies have not been performed on the relationship of age to the effects of promethazine in the pediatric ...
  • Each tablet of promethazine hydrochloride contains 12.5 mg, 25 mg, or 50 mg promethazine hydrochloride. (nih.gov)
  • Promethazine hydrochloride occurs as a white to faint yellow, practically odorless, crystalline powder which slowly oxidizes and turns blue on prolonged exposure to air. (nih.gov)
  • Promethazine hydrochloride tablets, USP are contraindicated for use in pediatric patients less than two years of age. (nih.gov)
  • Promethazine hydrochloride tablets, USP are contraindicated in comatose states, and in individuals known to be hypersensitive or to have had an idiosyncratic reaction to promethazine or to other phenothiazines. (nih.gov)
  • Solid promethazine hydrochloride is a white to faint-yellow, practically odorless, crystalline powder. (wikipedia.org)
  • Promethazine hydrochloride (HCl) is an antihistamine marketed under the brand names Phenergan and Pentazine. (findlaw.com)
  • General information about the safe and effective use of Promethazine Hydrochloride and Codeine Phosphate Oral Solution. (soxanddawgs.com)
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  • Keep Promethazine Hydrochloride and Codeine Phosphate Oral Solution in a tightly closed, child-resistant container and out of the light. (soxanddawgs.com)
  • The administration of promethazine hydrochloride in 25-mg doses will control minor transfusion reactions of an allergic nature. (soxanddawgs.com)
  • The FDA has notified healthcare professionals that a Boxed Warning is being added to the prescribing information for promethazine hydrochloride products, describing the risks of severe tissue injury, including gangrene, requiring amputation following intravenous administration of promethazine. (empr.com)
  • Promethazine hydrochloride injection is approved for a variety of uses including allergic reactions, sedation, motion sickness, nausea and vomiting associated with anesthesia and surgery, and as an adjunct to analgesics for control of postoperative pain. (empr.com)
  • Promethazine hydrochloride, a phenothiazine derivative, is chemically designated as (±)-10-[2-(Dimethylamino)propyl] phenothiazine monohydrochloride. (prescriptiondrugs.com)
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  • Promethazine comes as a tablet and syrup (liquid) to take by mouth and as a suppository to use rectally.When promethazine is used to treat allergies, it is usually taken one to four times daily, before meals and/or at bedtime. (medlineplus.gov)
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  • Precise measuring instruments should be used for dosing, when you use Codeine and Promethazine based cough syrup. (ahefv.com)
  • Its main ingredient is prescription-strength cough syrup containing codeine and promethazine. (recoveryhappens.com)
  • Originally, the active ingredient of "syrup" was cough syrup containing promethazine and codeine. (recoveryhappens.com)
  • Arrest trends indicate that people are traveling in from out of state because the drug is so easy to obtain in Texas.The drug Promethazine with Codeine is commonly known "on the street" as "syrup" and/or "lean," the latter due to the abusers' propensity of having difficulty in standing up straight. (recoveryhappens.com)
  • PROMETHAZINE (proe METH a zeen) is an antihistamine. (nationwidechildrens.org)
  • Promethazine is a first-generation antihistamine used to treat allergies, difficulty sleeping, and nausea. (wikipedia.org)
  • Promethazine is an antihistamine that relieves watery eyes, itchy eyes/nose/throat, runny nose , and sneezing . (medicinenet.com)
  • Promethazine is an antihistamine that reduces the effects of natural chemical histamine in the body. (cigna.com)
  • Promethazine is an antihistamine that works to treat allergic reactions such as sinus drainage or a runny nose, and it also reduces symptoms such as nausea and vomiting . (wisegeek.com)
  • Promethazine is an antihistamine. (cardiosmart.org)
  • Promethazine is an antihistamine used to relieve allergic rhinitis (seasonal allergy) symptoms including sneezing, runny nose, itching, and watery eyes and itching and swelling associated with uncomplicated allergic skin reactions. (peacehealth.org)
  • Promethazine is first generation antihistamine that belongs to the phenothiazine class and is used predominantly as an antiemetic to treat nausea and vomiting and prevent motion sickness. (nih.gov)
  • Promethazine (proe meth' a zeen) is a first generation antihistamine that is used widely to treat and prevent nausea and to a lesser extent to treat allergy symptoms and as a mild sedative. (nih.gov)
  • Promethazine is an antihistamine sometimes used as a sleeping pill . (mind.org.uk)
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  • In addition to the Boxed Warning, FDA is requiring a revision to the Dosage and Administration section to increase the visibility and accessibility of specific recommendations for the maximum concentration (25mg/mL) and rate of administration (25mg/min) when intravenous administration of promethazine is required. (empr.com)
  • ISMP discourages the use of injectable promethazine (any route) because of the risk of severe tissue damage (ISMP 2018). (drugs.com)
  • Jun 01, 2018 · Promethazine VC with Codeine Oral Solution contains codeine, a substance with a high potential for abuse similar to other opioids including morphine and codeine. (cdrnys.org)
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  • Promethazine is in a class of medications called phenothiazines. (medlineplus.gov)
  • tell your doctor and pharmacist if you are allergic to promethazine, other phenothiazines (certain medications used to treat mental illness, nausea, vomiting, severe hiccups, and other conditions) or any other medications. (medlineplus.gov)
  • Promethazine belongs to a class of drugs called phenothiazines. (medicalnewstoday.com)
  • Promethazine is a phenothiazine derivative which differs structurally from the antipsychotic phenothiazines by the presence of a branched side chain and no ring substitution. (nih.gov)
  • Promethazine, a phenothiazine derivative, is structurally different from the neuroleptic phenothiazines, with similar but different effects. (wikipedia.org)
  • Promethazine is in a group of drugs called phenothiazines (FEEN-oh-THYE-a-zeens). (cigna.com)
  • Despite widespread use and similarity to phenothiazines, promethazine has not been clearly linked to liver test abnormalities or to clinically apparent liver injury. (nih.gov)
  • Promethazine is used to relieve the symptoms of allergic reactions such as allergic rhinitis (runny nose and watery eyes caused by allergy to pollen, mold or dust), allergic conjunctivitis (red, watery eyes caused by allergies), allergic skin reactions, and allergic reactions to blood or plasma products. (medlineplus.gov)
  • Promethazine is used with other medications to treat anaphylaxis (sudden, severe allergic reactions) and the symptoms of the common cold such as sneezing, cough, and runny nose. (medlineplus.gov)
  • Promethazine helps control symptoms, but will not treat the cause of the symptoms or speed recovery. (medlineplus.gov)
  • When promethazine is used to relieve cold symptoms, it is usually taken every 4 to 6 hours as needed. (medlineplus.gov)
  • Promethazine is used to relieve or prevent the symptoms of hay fever, allergic conjunctivitis (inflammation of the eye), and other types of allergy or allergic reactions. (mayoclinic.org)
  • The combination of codeine and promethazine is used to treat cold or allergy symptoms such as runny nose, sneezing, and cough. (cardiosmart.org)
  • Codeine and promethazine may cause addiction or withdrawal symptoms in a newborn if the mother takes the medication during pregnancy. (cardiosmart.org)
  • Contact your doctor if your symptoms do not improve within a few days of using codeine and promethazine. (cardiosmart.org)
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  • METHODS: : We analyzed urine samples for the presence of promethazine and reviewed the clinical records for 334 methadone maintenance patients at the county methadone clinic. (rti.org)
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