A phenothiazine with actions similar to CHLORPROMAZINE but with less antipsychotic activity. It is primarily used in short-term treatment of disturbed behavior and as an antiemetic.
Compounds containing dibenzo-1,4-thiazine. Some of them are neuroactive.
A phenothiazine antipsychotic with actions and uses similar to those of CHLORPROMAZINE. Extrapyramidal symptoms may be more common than other side effects.
A phenothiazine used as an antipsychotic agent and as an antiemetic.
A phenothiazine antipsychotic used in the management of PHYCOSES, including SCHIZOPHRENIA.
A vital dye used as an indicator and biological stain. Various adverse effects have been observed in biological systems.
The prototypical phenothiazine antipsychotic drug. Like the other drugs in this class chlorpromazine's antipsychotic actions are thought to be due to long-term adaptation by the brain to blocking DOPAMINE RECEPTORS. Chlorpromazine has several other actions and therapeutic uses, including as an antiemetic and in the treatment of intractable hiccup.
A phenothiazine antipsychotic used principally in the treatment of NAUSEA; VOMITING; and VERTIGO. It is more likely than CHLORPROMAZINE to cause EXTRAPYRAMIDAL DISORDERS. (From Martindale, The Extra Pharmacopoeia, 30th ed, p612)
Agents that control agitated psychotic behavior, alleviate acute psychotic states, reduce psychotic symptoms, and exert a quieting effect. They are used in SCHIZOPHRENIA; senile dementia; transient psychosis following surgery; or MYOCARDIAL INFARCTION; etc. These drugs are often referred to as neuroleptics alluding to the tendency to produce neurological side effects, but not all antipsychotics are likely to produce such effects. Many of these drugs may also be effective against nausea, emesis, and pruritus.

Effects of promazine, chlorpromazine, d-amphetamine, and pentobarbital on treadle pressing by pigeons under a signalled shock-postponement schedule. (1/29)

The effects of promazine on treadle pressing to postpone the presentation of electric shock were studied in three pigeons. The effects of chlorpromazine, d-amphetamine, and pentobarbital were studied in two of these pigeons. Each treadle press postponed electric shock for 20 sec and presentation of a preshock stimulus for 14 sec. Selected doses of both promazine and chlorpromazine increased the rates of treadle pressing in all birds. The response-rate increases produced by promazine and chlorpromazine were due to increased conditional probabilities of treadle pressing both before and during the preshock stimulus. d-Amphetamine (1 and 3 mg/kg) slightly increased responding in one of the birds, but not to the extent that promazine or chlorpromazine did. In the other bird, the 10 mg/kg dose of d-amphetamine increased shock rate but did not change response rate. Some doses of d-amphetamine increased the conditional probabilities of responding both in the absence of the preshock signal and during the preshock signal in both birds. Pentobarbital only decreased response rates and increased shock rates.  (+info)

A previously unidentified acepromazine metabolite in humans: implications for the measurement of acepromazine in blood. (2/29)

High-performance liquid chromatography-diode-array detection results obtained during the investigation of two cases involving acepromazine prompted us to study the stability of the drug in blood. It was found that acepromazine can undergo in vitro conversion by human red blood cells to 2-(1-hydroxyethyl)promazine, a product that has been reported as a minor urinary metabolite in horse urine but not previously identified in humans. Further, our analytical findings in the two cases examined suggest that 2-(1-hydroxyethyl)promazine may be the major unconjugated metabolite of acepromazine in humans. These findings have important implications for the analytical toxicology of acepromazine.  (+info)

A liquid chromatographic method for the simultaneous determination of promethazine and three of its metabolites in plasma using electrochemical and UV detectors. (3/29)

A new assay method has been developed for the quantitation of promethazine (PMZ) with a sensitivity and reproducibility as good as any previously reported method. This method is also capable of quantitatively determining three metabolites of PMZ (monodemethylated, sulphoxidated, and monodemethylated sulphoxidated PMZ), which has not been previously described. The method uses high-performance liquid chromatography with amperometric and UV detection simultaneously and requires only one extraction step from serum with chloroform. The method uses trifluoperazine as the internal standard. The limit of detection level for PMZ is 1.0 ng/ml when a 0.2-mL specimen of plasma is assayed. A validation study is also conducted for evaluating the recovery, precision, linearity of response, sensitivity, and selectivity of the method.  (+info)

Intracellular distribution of psychotropic drugs in the grey and white matter of the brain: the role of lysosomal trapping. (4/29)

1. Since the brain is not a homogenous organ (i.e. the phospholipid pattern and density of lysosomes may vary in its different regions), in the present study we examined the uptake of psychotropic drugs by vertically cut slices of whole brain, grey (cerebral cortex) and white (corpus callosum, internal capsule) matter of the brain and by neuronal and astroglial cell cultures. 2. Moreover, we assessed the contribution of lysosomal trapping to total drug uptake (total uptake=lysosomal trapping+phospholipid binding) by tissue slices or cells conducting experiments in the presence and absence of 'lysosomal inhibitors', i.e., the lysosomotropic compound ammonium chloride (20 mM) or the Na(+)/H(+)-ionophore monensin (10 microM), which elevated the internal pH of lysosomes. The initial concentration of psychotropic drug in the incubation medium was 5 microM. 3. Both total uptake and lysosomal trapping of the antidepressants investigated (imipramine, amitriptyline, fluoxetine, sertraline) and neuroleptics (promazine, perazine, thioridazine) were higher in the grey matter and neurones than in the white matter and astrocytes, respectively. Lysosomal trapping of the psychotropics occurred mainly in neurones where thioridazine sertraline and perazine showed the highest degree of lysosomotropism. 4. Distribution interactions between antidepressants and neuroleptics took place in neurones via mutual inhibition of lysosomal trapping of drugs. 5. A differential number of neuronal and glial cells in the brain may mask the lysosomal trapping and the distribution interactions of less potent lysosomotropic drugs in vertically cut brain slices. 6. A reduction (via a distribution interaction) in the concentration of psychotropics in lysosomes (depot), which leads to an increase in their level in membranes and tissue fluids, may intensify the pharmacological action of the combined drugs.  (+info)

Spectrophotometric determination of vanadium(V) in minerals, steels, soil and biological samples using phenothiazine derivatives. (5/29)

Two simple, rapid and sensitive spectrophotometric methods have been proposed for the determination of vanadium(V) using butaperazine dimaleate (BPD) and propionyl promazine phosphate (PPP). These methods are based on the formation of red-colored radical cations on reaction with vanadium(V) in phosphoric acid medium, with their absorbance maxima at 513 nm. Beer's law is valid over the concentration range of 0.25-5.0 micrograms ml-1 and 0.2-4.0 micrograms ml-1, with Sandell's sensitivity values of 6.1 ng cm-2 and 6.0 ng cm-2 for BPD and PPP respectively. The proposed methods have been successfully applied to the analysis of vanadium steels, minerals, biological samples and soil samples.  (+info)

Simultaneous quantification of promazine hydrochloride and its sulfoxide in pharmaceutical preparations. (6/29)

The use of derivative UV-spectrophotometry is proposed for the simultaneous quantification of promazine hydrochloride in the presence of sulfoxide, and vice versa. For this purpose, mathematical parameters were established for generating derivative spectra of analytes. The determination of promazine was made using the first-order derivative (deltalambda = 10 nm, second polynomial degree) at 268 nm. The quantification of sulfoxide was achieved by applying third-derivative spectra (deltalambda = 14 nm, sixth polynomial degree) based on measurements of the amplitude at 342 - 344 nm. An elaborated method was successfully used to determine analytes in commercial promazine pharmaceuticals. The obtained results agreed well with those obtained by the HPLC method.  (+info)

Examination of iron (III) and hexacyanoferrate (III) ions as reagents for the spectrophotometric determination of promazine and perazine. (7/29)

Iron (III) chloride and potassium hexacyanoferrate (III) have been tested as reagents for the determination of promazine hydrochloride and perazine. The methods are based on the oxidation of phenothiazines by FeCl3 and K3[Fe(CN)6] in perchloric acid medium. The optimal conditions for the formation of oxidation products of promazine and perazine were examined. The absorption spectra in the UV-VIS region were recorded.  (+info)

Contribution of human cytochrome p-450 isoforms to the metabolism of the simplest phenothiazine neuroleptic promazine. (8/29)

1. The aim of the present study was to identify human cytochrome p-450 isoforms (CYPs) involved in 5-sulphoxidation and N-demethylation of the simplest phenothiazine neuroleptic promazine in human liver. 2. The experiments were performed in the following in vitro models: (A). a study of promazine metabolism in liver microsomes-(a). correlations between the rate of promazine metabolism and the level and activity of CYPs; (b). the effect of specific inhibitors on the rate of promazine metabolism (inhibitors: CYP1A2-furafylline, CYP2D6-quinidine, CYP2A6+CYP2E1-diethyldithiocarbamic acid, CYP2C9-sulfaphenazole, CYP2C19-ticlopidine, CYP3A4-ketoconazole); (B). promazine biotransformation by cDNA-expressed human CYPs (Supersomes 1A1, 1A2, 2A6, 2B6, 2C9, 2C19, 2E1, 3A4); (C). promazine metabolism in a primary culture of human hepatocytes treated with specific inducers (rifampicin-CYP3A4, CYP2B6 and CYP2C inducer, 2,3,7,8-tetrachlordibenzeno-p-dioxin (TCDD)-CYP1A1/1A2 inducer). 3. In human liver microsomes, the formation of promazine 5-sulphoxide and N-desmethylpromazine was significantly correlated with the level of CYP1A2 and ethoxyresorufin O-deethylase and acetanilide 4-hydroxylase activities, as well as with the level of CYP3A4 and cyclosporin A oxidase activity. Moreover, the formation of N-desmethylpromazine was correlated well with S-mephenytoin 4'-hydroxylation. 4. Furafylline (a CYP1A2 inhibitor) and ketoconazole (a CYP3A4 inhibitor) significantly decreased the rate of promazine 5-sulphoxidation, while furafylline and ticlopidine (a CYP2C19 inhibitor) significantly decreased the rate of promazine N-demethylation in human liver microsomes. 5. The cDNA-expressed human CYPs generated different amounts of promazine metabolites, but the rates of CYP isoforms to catalyse promazine metabolism at therapeutic concentration (10 microM) was as follows: 1A1>2B6>1A2>2C9>3A4>2E1>2A6>2D6>2C19 for 5-sulphoxidation and 2C19>2B6>1A1>1A2>2D6>3A4>2C9>2E1>2A6 for N-demethylation. The highest intrinsic clearance (V(max)/K(m)) was found for CYP1A subfamily, CYP3A4 and CYP2B6 in the case of 5- sulphoxidation, and for CYP2C19, CYP1A subfamily and CYP2B6 in the case of N-demethylation. 6. In a primary culture of human hepatocytes, TCDD (a CYP1A subfamily inducer), as well as rifampicin (mainly a CYP3A4 inducer) induced the formation of promazine 5-sulphoxide and N-desmethylpromazine. 7. Regarding the relative expression of various CYPs in human liver, the obtained results indicate that CYP1A2 and CYP3A4 are the main isoforms responsible for 5-sulphoxidation, while CYP1A2 and CYP2C19 are the basic isoforms that catalyse N-demethylation of promazine in human liver. Of the other isoforms studied, CYP2C9 and CYP3A4 contribute to a lesser degree to promazine 5-sulphoxidation and N-demethylation, respectively. The role of CYP2A6, CYP2B6, CYP2D6 and CYP2E1 in the investigated metabolic pathways of promazine seems negligible.  (+info)

Promazine is a type of medication known as a phenothiazine antipsychotic. It works by blocking the action of dopamine, a neurotransmitter in the brain that is involved in emotion and thought. Promazine is primarily used to treat schizophrenia and other psychotic disorders, as well as to manage agitation and anxiety in certain medical conditions. It may also be used for its sedative effects in the management of insomnia or related sleep disturbances.

Promazine was first synthesized in the 1940s and has been used in clinical practice since then. It is available in various forms, including tablets and injectable solutions, and is typically administered two to four times a day. Common side effects of promazine include dry mouth, blurred vision, constipation, dizziness, and orthostatic hypotension (a sudden drop in blood pressure upon standing). Less commonly, it can cause extrapyramidal symptoms, such as tremors, rigidity, and akathisia (restlessness and inability to sit still).

It is important to note that promazine and other phenothiazine antipsychotics have been largely replaced by newer, atypical antipsychotic medications due to their greater efficacy and lower risk of extrapyramidal side effects. However, promazine may still be used in certain cases where its specific properties are desired or when other treatments have failed. As with any medication, it should only be used under the close supervision of a healthcare provider, who can monitor for potential adverse effects and adjust the dosage as needed.

Phenothiazines are a class of heterocyclic organic compounds that contain a phenothiazine nucleus, which consists of a pair of benzene rings fused to a thiazine ring. They have been widely used in medicine as antipsychotic drugs for the treatment of various mental disorders such as schizophrenia and bipolar disorder.

Phenothiazines work by blocking dopamine receptors in the brain, which helps to reduce the symptoms of psychosis such as hallucinations, delusions, and disordered thinking. They also have sedative and antiemetic (anti-nausea) effects. However, they can cause a range of side effects including extrapyramidal symptoms (involuntary muscle movements), tardive dyskinesia (irreversible movement disorder), and neuroleptic malignant syndrome (a rare but potentially fatal reaction to antipsychotic drugs).

Examples of phenothiazine drugs include chlorpromazine, thioridazine, and promethazine. While they have been largely replaced by newer atypical antipsychotics, phenothiazines are still used in some cases due to their lower cost and effectiveness in treating certain symptoms.

Perazine is not a medical term itself, but it's a common name for the antipsychotic medication called "perazine hydrochloride." Here's the medical definition:

Perazine Hydrochloride: A first-generation antipsychotic drug primarily used to treat chronic schizophrenia and related psychotic disorders. It belongs to the class of diphenylbutylpiperidine derivatives and works by blocking dopamine receptors in the brain, which helps reduce the symptoms of psychosis such as hallucinations, delusions, and disordered thought processes. Perazine hydrochloride may also have some sedative and antiemetic properties. Common side effects include extrapyramidal symptoms (involuntary muscle movements), dry mouth, blurred vision, constipation, and orthostatic hypotension.

Triflupromazine is an antipsychotic medication that belongs to the class of phenothiazines. It works by blocking dopamine receptors in the brain, which helps to reduce psychotic symptoms such as hallucinations, delusions, and hostility.

The medical definition of Triflupromazine is:

A trifluoromethyl phenothiazine antipsychotic drug, with sedative and hypotensive effects. It is used in the management of chronic schizophrenia, agitated states, and severe behavior problems in children. Its side effects include extrapyramidal symptoms (EPS), such as tremors, rigidity, and akathisia, as well as anticholinergic effects like dry mouth and constipation. It may also cause orthostatic hypotension, drowsiness, and weight gain.

Thioridazine is an antipsychotic medication that belongs to the class of phenothiazines. It works by blocking dopamine receptors in the brain, which helps to reduce psychotic symptoms such as delusions, hallucinations, and disordered thought processes. Thioridazine is used to treat schizophrenia and other mental disorders associated with anxiety, agitation, or hostility.

It's important to note that thioridazine has been associated with serious side effects, including prolongation of the QT interval on the electrocardiogram (ECG), which can lead to potentially fatal arrhythmias. Therefore, its use is generally reserved for patients who have not responded to other antipsychotic medications or who cannot tolerate them. Thioridazine has been withdrawn from the market in many countries due to these safety concerns.

Neutral Red is not a medical term itself, but it is a dye that is widely used in medical research and clinical settings. Neutral Red is a supravital stain, which means it can be used to selectively stain living cells without staining non-living or dead cells. It is an acidophilic dye, which stains structures that have an affinity for acidic dyes.

Neutral Red is commonly used in cell culture to assess the viability and cytotoxicity of various compounds, as well as to measure the activity of lysosomes in cells. The dye can be taken up by living cells and accumulate in lysosomes, where it exhibits fluorescence. When cells are treated with a cytotoxic compound, the integrity of their lysosomal membranes may be disrupted, leading to the release of Neutral Red into the cytosol and a decrease in fluorescence intensity.

Therefore, Neutral Red can serve as an indicator of cell health and can be used to monitor the effects of various treatments on cells in vitro.

Chlorpromazine is a type of antipsychotic medication, also known as a phenothiazine. It works by blocking dopamine receptors in the brain, which helps to reduce the symptoms of psychosis such as hallucinations, delusions, and disordered thinking. Chlorpromazine is used to treat various mental health conditions including schizophrenia, bipolar disorder, and severe behavioral problems in children. It may also be used for the short-term management of severe anxiety or agitation, and to control nausea and vomiting.

Like all medications, chlorpromazine can have side effects, which can include drowsiness, dry mouth, blurred vision, constipation, weight gain, and sexual dysfunction. More serious side effects may include neurological symptoms such as tremors, rigidity, or abnormal movements, as well as cardiovascular problems such as low blood pressure or irregular heart rhythms. It is important for patients to be monitored closely by their healthcare provider while taking chlorpromazine, and to report any unusual symptoms or side effects promptly.

Prochlorperazine is an antipsychotic drug, specifically a phenothiazine derivative. It works by blocking dopamine receptors in the brain, which helps to reduce psychotic symptoms such as hallucinations and delusions, and also has antiemetic (anti-nausea and vomiting) effects.

Prochlorperazine is used to treat various conditions, including:

* Schizophrenia and other psychotic disorders
* Nausea and vomiting, including motion sickness and postoperative nausea and vomiting
* Severe anxiety or agitation
* Tension headaches

The drug can be administered orally, intramuscularly, or rectally, depending on the formulation. Common side effects of prochlorperazine include drowsiness, dry mouth, blurred vision, and constipation. More serious side effects can include neurological symptoms such as tardive dyskinesia (involuntary movements), neuroleptic malignant syndrome (a life-threatening condition characterized by fever, muscle rigidity, and autonomic dysfunction), and seizures. Prochlorperazine should be used with caution in elderly patients, those with a history of seizures or cardiovascular disease, and those taking other medications that may interact with it.

Antipsychotic agents are a class of medications used to manage and treat psychosis, which includes symptoms such as delusions, hallucinations, paranoia, disordered thought processes, and agitated behavior. These drugs work by blocking the action of dopamine, a neurotransmitter in the brain that is believed to play a role in the development of psychotic symptoms. Antipsychotics can be broadly divided into two categories: first-generation antipsychotics (also known as typical antipsychotics) and second-generation antipsychotics (also known as atypical antipsychotics).

First-generation antipsychotics, such as chlorpromazine, haloperidol, and fluphenazine, were developed in the 1950s and have been widely used for several decades. They are generally effective in reducing positive symptoms of psychosis (such as hallucinations and delusions) but can cause significant side effects, including extrapyramidal symptoms (EPS), such as rigidity, tremors, and involuntary movements, as well as weight gain, sedation, and orthostatic hypotension.

Second-generation antipsychotics, such as clozapine, risperidone, olanzapine, quetiapine, and aripiprazole, were developed more recently and are considered to have a more favorable side effect profile than first-generation antipsychotics. They are generally effective in reducing both positive and negative symptoms of psychosis (such as apathy, anhedonia, and social withdrawal) and cause fewer EPS. However, they can still cause significant weight gain, metabolic disturbances, and sedation.

Antipsychotic agents are used to treat various psychiatric disorders, including schizophrenia, bipolar disorder, major depressive disorder with psychotic features, delusional disorder, and other conditions that involve psychosis or agitation. They can be administered orally, intramuscularly, or via long-acting injectable formulations. The choice of antipsychotic agent depends on the individual patient's needs, preferences, and response to treatment, as well as the potential for side effects. Regular monitoring of patients taking antipsychotics is essential to ensure their safety and effectiveness.

... , given as promazine hydrochloride, is one of the primary tranquilizers used by veterinarians as a pre-anaesthesia ... "Promazine (Primazine, Prozine)". Davis's Drug Guide. Retrieved 6 August 2021. Davis C (2007). "Promazine". In Enna SJ, Bylund ... Promazine was approved for medical use in the United States in the 1950s, although it is no longer commercially available there ... Promazine (brand name Sparine among others), is used as a short-term add-on treatment for psychomotor agitation. Its approved ...
Promazine • Sulforidazine • Sulpiride • Sultopride • Thioridazine • Thiothixene • Trifluoperazine • Triflupromazine • ...
Both promethazine and promazine exhibit comparable neuroleptic potency, with a neuroleptic potency of 0.5. However, dosages ... "promazine , Ligand Activity Charts , IUPHAR/BPS Guide to PHARMACOLOGY". www.guidetopharmacology.org. Retrieved 2023-05-18. ... Despite structural differences, promethazine exhibits a strikingly similar binding profile to promazine, another phenothiazine ...
... and promazine: a "double blind" comparative study in mental geriatrics]". Acta Neurologica et Psychiatrica Belgica ( ...
Non-phenothiazine False Positives and the Separation of Phencyclidine-promazine Combinations. Microgram 7 (1974) 129-130 ...
This large promazine dose was not effective and may have contributed to the animal's death. It died an hour and 40 minutes ... Beginning twenty minutes later, West and his colleagues administered the antipsychotic promazine hydrochloride; they injected a ...
... promazine, etc.); butyrophenones (haloperidol, benperidol, etc.); metoclopramide and Tetrabenazine. 1-Methyl-4-phenyl-1,2,3,6- ...
It differs from promazine only by the replacement of one carbon atom with a nitrogen atom in the tricyclic ring system. ...
... and other antipsychotics with sedative properties such as promazine and thioridazine are among the most potent ...
... promazine MeSH D03.494.741.670 - promethazine MeSH D03.494.741.780 - thiethylperazine MeSH D03.494.741.843 - thioridazine MeSH ...
Perphenazine Pergolide Pericyazine Pimozide Pipamperone Pipotiazine Pramipexole Pregabalin Primidone Prochlorperazine Promazine ...
Chlorpromazine Chlorprothixene Levomepromazine Mesoridazine Periciazine Promazine Thioridazine† (withdrawn by brand-name ...
The molecular formula C17H20N2S (molar mass: 284.42 g/mol, exact mass: 284.1347 u) may refer to: Isopromethazine Promazine ...
Norfluoxetine Nortriptyline Paroxetine Penfluridol Perhexiline Perphenazine Pimethixene Pimozide Profenamine Promazine ...
... promazine MeSH D02.886.369.670 - promethazine MeSH D02.886.369.780 - thiethylperazine MeSH D02.886.369.843 - thioridazine MeSH ...
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z Notes References Al ace Slang for the drug acepromazine or acetyl promazine ...
Under the instruction of his physicians, he was held down and injected with promazine, a major tranquilliser, at three times ...
Simone Courvoisier tested the series on laboratory rats and discovered that RP 4560 (chlorinated promazine, later known as ...
N05AA01 Chlorpromazine N05AA02 Levomepromazine N05AA03 Promazine N05AA04 Acepromazine N05AA05 Triflupromazine N05AA06 ...
Proloprim Promacta Promapar promazine (INN) promegestone (INN) promelase (INN) promestriene (INN) Prometh Promethacon ...
... these included Promazine (a strongly sedative antipsychotic Eden used to induce sleep and counteract the stimulants he took), ...
Promazine, given as promazine hydrochloride, is one of the primary tranquilizers used by veterinarians as a pre-anaesthesia ... "Promazine (Primazine, Prozine)". Daviss Drug Guide. Retrieved 6 August 2021. Davis C (2007). "Promazine". In Enna SJ, Bylund ... Promazine was approved for medical use in the United States in the 1950s, although it is no longer commercially available there ... Promazine (brand name Sparine among others), is used as a short-term add-on treatment for psychomotor agitation. Its approved ...
A Novel Promazine Derivative Shows High in vitro and in vivo Antimicrobial Activity Against Staphylococcus aureus. Publikation ...
Explore the 1 paper that mention a possible interaction between Promazine and Calcium Supplement. ... Promazine behaved as a competitive antagonist to the association of calcium with hemoglobin-free erythrocyte membrane when the ...
Pokrovskiĭ A.A., Archakov A.I., Devichenskiĭ V.M. (1965) Effect of promazine on the activity of some liver and blood enzymes in ... Effect of promazine on the activity of some liver and blood enzymes in carbon tetrachloride poisoning // Voprosy Meditsinskoi ... Effect of promazine on the activity of some liver and blood enzymes in carbon tetrachloride poisoning. ... Pokrovskiĭ A.A. et al., Effect of promazine on the activity of some liver and blood enzymes in carbon tetrachloride poisoning ...
Acute intermittent porphyria (AIP) is one of the porphyrias, a group of diseases involving defects in heme metabolism and that results in excessive secretion of porphyrins and porphyrin precursors. AIP manifests itself by abdomen pain, neuropathies, and constipation, but, unlike most types of porphyria, patients with AIP do not have a rash.
Detailed drug Information for Ketalar. Includes common brand names, drug descriptions, warnings, side effects and dosing information.
Detailed drug Information for Xolox. Includes common brand names, drug descriptions, warnings, side effects and dosing information.
This medicine may cause some people to be agitated, irritable, or display other abnormal behaviors, such as feeling sad or hopeless, getting upset easily, or feeling nervous, restless, or hostile. It may also cause some people to have suicidal thoughts and tendencies or to become more depressed. If you or your caregiver notice any of these side effects, tell your doctor right away. This medicine may cause respiratory depression, a serious breathing problem that can be life-threatening, when used together with narcotic pain medicines. Check with your doctor right away if you have pale or blue lips, fingernails, or skin, difficult or troubled breathing, or irregular, fast or slow, or shallow breathing. Check with your doctor right away if you have a fever, rash, swollen, painful, or tender lymph glands in the neck, armpit, or groin, unusual bleeding or bruising, or yellow eyes or skin. These may be symptoms of a serious and life-threatening allergic reaction called drug reaction with eosinophilia ...
Promazine. Promethazine. Propiomazine. Thiethylperazine. Thioridazine. Trifluoperazine. Triflupromazine. Trimeprazine. Back to ...
Methadone ELISA is a screening test kit for the detection of drugs and/or their metabolites in forensic matrices and is intended for forensic use only.
Benperidol and promazine: a "double blind" comparative study in mental geriatrics]". Acta Neurologica et Psychiatrica Belgica ( ...
Chlorpromazine • Fluphenazine • Mesoridazine • Perphenazine • Prochlorperazine • Promazine • Thioridazine/Sulforidazine • ...
EDQM Strasbourg, France 20/01/2023 Diminuer la taille du texte Augmenter la taille du texte Imprimer la page Imprimer en PDF Supplement 11.2 of the European Pharmacopoeia (Ph. Eur.) is now...
Fluanisone Promazine. Flupentixol Promethazine. Fluphenazine Sulpiride. Fluspiriline Thioridazine. Haloperidol. *Product names ...
Promazine HCl oral. phenothiazines - oral. Promethazine HCl injection. promethazine - injection. Promethazine HCl oral ...
promazine. Monitor Closely (1)promazine and trimethoprim both increase QTc interval. Modify Therapy/Monitor Closely. ... promazine. promazine and trimethoprim both increase QTc interval. Modify Therapy/Monitor Closely. ...
promazine. Monitor Closely (1)promazine, pseudoephedrine. Mechanism: unknown. Use Caution/Monitor. Risk of cardiac arrhythmia ... promazine. promazine, pseudoephedrine. Mechanism: unknown. Use Caution/Monitor. Risk of cardiac arrhythmia or sudden death, ...
2-(1-Hydroxyethyl)promazine sulfoxide. 10. 16β-Hydroxy-stanozolol. 1 Amitriptyline. 50 ...
2-(1-hydroxyethyl)promazine sulfoxide. Note: C19H24N2O2S; Mwt = 344.47. -. Animal. -. -. ECOTOXICOLOGY. Terrestrial ...
... promazine [e.g., Sparine], promethazine [e.g., Phenergan], thioridazine [e.g., Mellaril], trifluoperazine [e.g., Stelazine], ...
Promazine 8.8 8.5 ± 0.1 Testosterone 17 17.2 ± 0.6 Verapamil 16 14.7 ± 1.1 16 7.9 ± 1.2 SNC+ 17 4.8 ± 0.6 SNC+ 14 1.9 ± 0.3 ... 12 mg of promazine, and 25 mg of verapamil and atenolol, which were dissolved in ethanol (1000 μL). 100 μL of these solutions ...
Effects of caffeine and promazine hydrochloride on plasma catecholamines in thoroughbreds at rest and during treadmill exercise ... Effects of caffeine and promazine hydrochloride on plasma catecholamines in thoroughbreds at rest and during treadmill exercise ... Effects of caffeine and promazine hydrochloride on plasma catecholamines in thoroughbreds at rest and during treadmill exercise ... Effects of caffeine and promazine hydrochloride on plasma catecholamines in thoroughbreds at rest and during treadmill exercise ...
A certain amount of amino-ethers produced in the laboratory of the authors were studied for a protective effect of promazine ...
Phenothiazeines: SAR of Phenothiazeines - Promazine hydrochloride, Chlorpromazine hydrochlo- ride*, Triflupromazine, ...
Ammonium-bridged bis(promazine) type compounds (BA-PF6: [Y-N+Me2-CH2-R-CH2-N+Me2-Y]2+[PF6-]2, Y = 3-(phenothiazin-10-yl)propyl ...
... promazine, thioridazine, prochlorperazine, trifluoperazine, trimeprazine), clozapine, risperidone, imipramine, desipramine, ...
... promazine (Sparine), promethazine (Phenergan), rifampin (Rifadin, Rimactane), thioridazine (Mellaril), tranylcypromine (Parnate ...
The effects of chlorpromazine and promazine on ATP and nucleic acid levels in the rat brain suggested that these drugs induce a ...
The first stop for professional medicines advice
  • Promazine (brand name Sparine among others), is used as a short-term add-on treatment for psychomotor agitation. (wikipedia.org)
  • RP, Lee DC important is it decanoate, valproate may have increased Nandrolone Decanoate levels of haloperidol, clozapine, and promazine. (hewedi.com)
  • The effects of chlorpromazine and promazine on ATP and nucleic acid levels in the rat brain suggested that these drugs induce a state of decreased activity in selected subcortical areas. (erowid.org)
  • Promazine, given as promazine hydrochloride, is one of the primary tranquilizers used by veterinarians as a pre-anaesthesia injection in horses. (wikipedia.org)
  • A certain amount of amino-ethers produced in the laboratory of the authors were studied for a protective effect of promazine and LSD. (erowid.org)
  • It is available in the US for veterinary use under the names Promazine and Tranquazine. (wikipedia.org)
  • In addition to the cruelty allegedly shown toward the living animals on her property, McKnight is accused of fatally poisoning one horse with Promazine, causing it "an unnecessary amount of suffering before it died," according to court documents. (chronline.com)
  • Jaundice secondary to promazine, and an analysis of possible cross sensitivities between phenothiazine derivatives. (nih.gov)
  • Promazine is a phenothiazine that is used as an antiemetic and antipsychotics treating agitated states, psychosis and schizophrenia. (affygility.com)
  • Promazine is a phenothiazine antipsychotic. (guidetopharmacology.org)
  • 4. Contribution of human cytochrome p-450 isoforms to the metabolism of the simplest phenothiazine neuroleptic promazine. (nih.gov)
  • The inhibition of quorum sensing (QS) by phenothiazines and structurally related molecules, e. g. amitriptyline, promethazine, acridine orange, imipramine, promazine, diethazine, desipramine, desertomycin and 5-fluorouracil as positive control was studied with Chromobacterium violaceum 026 as a sensor strain, which detects short carbon chain AHLs by the development of a purple pigment. (unl.pt)
  • For that violation, a horse under his care, Symbolic, tested positive for the tranquilizer acepromazine and its metabolite, 2-(1-hydroxyethyl) promazine sulfoxide, at the Aiken Spring Classic Masters Horse Show (S.C.), held April 15-19, 2015. (chronofhorse.com)
  • Hepatic, primarily to N-desmethylpromazine and promazine sulfoxide. (minclinic.ru)
  • promazine = desipramine. (unl.pt)