Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
The worsening of a disease over time. This concept is most often used for chronic and incurable diseases where the stage of the disease is an important determinant of therapy and prognosis.
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
Elements of limited time intervals, contributing to particular results or situations.
Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.
A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.
An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.
Studies in which subsets of a defined population are identified. These groups may or may not be exposed to factors hypothesized to influence the probability of the occurrence of a particular disease or other outcome. Cohorts are defined populations which, as a whole, are followed in an attempt to determine distinguishing subgroup characteristics.
The proportion of survivors in a group, e.g., of patients, studied and followed over a period, or the proportion of persons in a specified group alive at the beginning of a time interval who survive to the end of the interval. It is often studied using life table methods.
A class of statistical procedures for estimating the survival function (function of time, starting with a population 100% well at a given time and providing the percentage of the population still well at later times). The survival analysis is then used for making inferences about the effects of treatments, prognostic factors, exposures, and other covariates on the function.
The number of new cases of a given disease during a given period in a specified population. It also is used for the rate at which new events occur in a defined population. It is differentiated from PREVALENCE, which refers to all cases, new or old, in the population at a given time.
Pathologic processes that affect patients after a surgical procedure. They may or may not be related to the disease for which the surgery was done, and they may or may not be direct results of the surgery.
Methods which attempt to express in replicable terms the extent of the neoplasm in the patient.
An infant during the first month after birth.
Age as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or the effect of a circumstance. It is used with human or animal concepts but should be differentiated from AGING, a physiological process, and TIME FACTORS which refers only to the passage of time.
The complex series of phenomena, occurring between the end of one CELL DIVISION and the end of the next, by which cellular material is duplicated and then divided between two daughter cells. The cell cycle includes INTERPHASE, which includes G0 PHASE; G1 PHASE; S PHASE; and G2 PHASE, and CELL DIVISION PHASE.
Levels within a diagnostic group which are established by various measurement criteria applied to the seriousness of a patient's disorder.
A nonparametric method of compiling LIFE TABLES or survival tables. It combines calculated probabilities of survival and estimates to allow for observations occurring beyond a measurement threshold, which are assumed to occur randomly. Time intervals are defined as ending each time an event occurs and are therefore unequal. (From Last, A Dictionary of Epidemiology, 1995)
In screening and diagnostic tests, the probability that a person with a positive test is a true positive (i.e., has the disease), is referred to as the predictive value of a positive test; whereas, the predictive value of a negative test is the probability that the person with a negative test does not have the disease. Predictive value is related to the sensitivity and specificity of the test.
The return of a sign, symptom, or disease after a remission.
A set of techniques used when variation in several variables has to be studied simultaneously. In statistics, multivariate analysis is interpreted as any analytic method that allows simultaneous study of two or more dependent variables.
Tomography using x-ray transmission and a computer algorithm to reconstruct the image.
The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.
The transfer of a neoplasm from one organ or part of the body to another remote from the primary site.
Histochemical localization of immunoreactive substances using labeled antibodies as reagents.
Tumors or cancer of the human BREAST.
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
The qualitative or quantitative estimation of the likelihood of adverse effects that may result from exposure to specified health hazards or from the absence of beneficial influences. (Last, Dictionary of Epidemiology, 1988)
The local recurrence of a neoplasm following treatment. It arises from microscopic cells of the original neoplasm that have escaped therapeutic intervention and later become clinically visible at the original site.
Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.
Period after successful treatment in which there is no appearance of the symptoms or effects of the disease.
The period of confinement of a patient to a hospital or other health facility.
A cell line derived from cultured tumor cells.
A distribution in which a variable is distributed like the sum of the squares of any given independent random variable, each of which has a normal distribution with mean of zero and variance of one. The chi-square test is a statistical test based on comparison of a test statistic to a chi-square distribution. The oldest of these tests are used to detect whether two or more population distributions differ from one another.
Tumors or cancer of the PROSTATE.
The total number of cases of a given disease in a specified population at a designated time. It is differentiated from INCIDENCE, which refers to the number of new cases in the population at a given time.
Ability of neoplasms to infiltrate and actively destroy surrounding tissue.
Molecular products metabolized and secreted by neoplastic tissue and characterized biochemically in cells or body fluids. They are indicators of tumor stage and grade as well as useful for monitoring responses to treatment and predicting recurrence. Many chemical groups are represented including hormones, antigens, amino and nucleic acids, enzymes, polyamines, and specific cell membrane proteins and lipids.
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action in neoplastic tissue.
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.
Removal and pathologic examination of specimens in the form of small pieces of tissue from the living body.
Tumors or cancer of the LUNG.
A malignant epithelial tumor with a glandular organization.
Statistical models used in survival analysis that assert that the effect of the study factors on the hazard rate in the study population is multiplicative and does not change over time.
The treatment of a disease or condition by several different means simultaneously or sequentially. Chemoimmunotherapy, RADIOIMMUNOTHERAPY, chemoradiotherapy, cryochemotherapy, and SALVAGE THERAPY are seen most frequently, but their combinations with each other and surgery are also used.
Statistical models which describe the relationship between a qualitative dependent variable (that is, one which can take only certain discrete values, such as the presence or absence of a disease) and an independent variable. A common application is in epidemiology for estimating an individual's risk (probability of a disease) as a function of a given risk factor.
The statistical reproducibility of measurements (often in a clinical context), including the testing of instrumentation or techniques to obtain reproducible results. The concept includes reproducibility of physiological measurements, which may be used to develop rules to assess probability or prognosis, or response to a stimulus; reproducibility of occurrence of a condition; and reproducibility of experimental results.
Substances that inhibit or prevent the proliferation of NEOPLASMS.
A repeat operation for the same condition in the same patient due to disease progression or recurrence, or as followup to failed previous surgery.
Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.
Non-invasive method of demonstrating internal anatomy based on the principle that atomic nuclei in a strong magnetic field absorb pulses of radiofrequency energy and emit them as radiowaves which can be reconstructed into computerized images. The concept includes proton spin tomographic techniques.
All of the processes involved in increasing CELL NUMBER including CELL DIVISION.
The use of two or more chemicals simultaneously or sequentially in the drug therapy of neoplasms. The drugs need not be in the same dosage form.
The former British crown colony located off the southeast coast of China, comprised of Hong Kong Island, Kowloon Peninsula, and New Territories. The three sites were ceded to the British by the Chinese respectively in 1841, 1860, and 1898. Hong Kong reverted to China in July 1997. The name represents the Cantonese pronunciation of the Chinese xianggang, fragrant port, from xiang, perfume and gang, port or harbor, with reference to its currents sweetened by fresh water from a river west of it.
Hospitals maintained by a university for the teaching of medical students, postgraduate training programs, and clinical research.
Studies which start with the identification of persons with a disease of interest and a control (comparison, referent) group without the disease. The relationship of an attribute to the disease is examined by comparing diseased and non-diseased persons with regard to the frequency or levels of the attribute in each group.
A class of statistical methods applicable to a large set of probability distributions used to test for correlation, location, independence, etc. In most nonparametric statistical tests, the original scores or observations are replaced by another variable containing less information. An important class of nonparametric tests employs the ordinal properties of the data. Another class of tests uses information about whether an observation is above or below some fixed value such as the median, and a third class is based on the frequency of the occurrence of runs in the data. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed, p1284; Corsini, Concise Encyclopedia of Psychology, 1987, p764-5)
The confinement of a patient in a hospital.
A country in western Europe bordered by the Atlantic Ocean, the English Channel, the Mediterranean Sea, and the countries of Belgium, Germany, Italy, Spain, Switzerland, the principalities of Andorra and Monaco, and by the duchy of Luxembourg. Its capital is Paris.
The frequency of different ages or age groups in a given population. The distribution may refer to either how many or what proportion of the group. The population is usually patients with a specific disease but the concept is not restricted to humans and is not restricted to medicine.
A carcinoma derived from stratified SQUAMOUS EPITHELIAL CELLS. It may also occur in sites where glandular or columnar epithelium is normally present. (From Stedman, 25th ed)
A medical facility which provides a high degree of subspecialty expertise for patients from centers where they received SECONDARY CARE.
Diseases of the domestic dog (Canis familiaris). This term does not include diseases of wild dogs, WOLVES; FOXES; and other Canidae for which the heading CARNIVORA is used.
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
Tumors or cancer of the LIVER.
Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.
Includes the spectrum of human immunodeficiency virus infections that range from asymptomatic seropositivity, thru AIDS-related complex (ARC), to acquired immunodeficiency syndrome (AIDS).
Recording of pertinent information concerning patient's illness or illnesses.
Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.
Maleness or femaleness as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or effect of a circumstance. It is used with human or animal concepts but should be differentiated from SEX CHARACTERISTICS, anatomical or physiological manifestations of sex, and from SEX DISTRIBUTION, the number of males and females in given circumstances.
Results of conception and ensuing pregnancy, including LIVE BIRTH; STILLBIRTH; SPONTANEOUS ABORTION; INDUCED ABORTION. The outcome may follow natural or artificial insemination or any of the various ASSISTED REPRODUCTIVE TECHNIQUES, such as EMBRYO TRANSFER or FERTILIZATION IN VITRO.
Transfer of a neoplasm from its primary site to lymph nodes or to distant parts of the body by way of the lymphatic system.
The presence of co-existing or additional diseases with reference to an initial diagnosis or with reference to the index condition that is the subject of study. Comorbidity may affect the ability of affected individuals to function and also their survival; it may be used as a prognostic indicator for length of hospital stay, cost factors, and outcome or survival.
Hospitals engaged in educational and research programs, as well as providing medical care to the patients.
Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care. (Dictionary of Health Services Management, 2d ed)
Tumors or cancer of the SKIN.
The end-stage of CHRONIC RENAL INSUFFICIENCY. It is characterized by the severe irreversible kidney damage (as measured by the level of PROTEINURIA) and the reduction in GLOMERULAR FILTRATION RATE to less than 15 ml per min (Kidney Foundation: Kidney Disease Outcome Quality Initiative, 2002). These patients generally require HEMODIALYSIS or KIDNEY TRANSPLANTATION.
Cell changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm, and other attributes conferring the ability to invade, metastasize, and kill.
A malignant neoplasm made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases. It is a histological type of neoplasm but is often wrongly used as a synonym for "cancer." (From Dorland, 27th ed)
Studies in which variables relating to an individual or group of individuals are assessed over a period of time.
Neoplasms of the intracranial components of the central nervous system, including the cerebral hemispheres, basal ganglia, hypothalamus, thalamus, brain stem, and cerebellum. Brain neoplasms are subdivided into primary (originating from brain tissue) and secondary (i.e., metastatic) forms. Primary neoplasms are subdivided into benign and malignant forms. In general, brain tumors may also be classified by age of onset, histologic type, or presenting location in the brain.
Therapy with two or more separate preparations given for a combined effect.
Disease having a short and relatively severe course.
A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)
A measure of the quality of health care by assessment of unsuccessful results of management and procedures used in combating disease, in individual cases or series.
Proteins that control the CELL DIVISION CYCLE. This family of proteins includes a wide variety of classes, including CYCLIN-DEPENDENT KINASES, mitogen-activated kinases, CYCLINS, and PHOSPHOPROTEIN PHOSPHATASES as well as their putative substrates such as chromatin-associated proteins, CYTOSKELETAL PROTEINS, and TRANSCRIPTION FACTORS.
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
A variation of the PCR technique in which cDNA is made from RNA via reverse transcription. The resultant cDNA is then amplified using standard PCR protocols.
Time schedule for administration of a drug in order to achieve optimum effectiveness and convenience.
Tumors or cancer of the COLON or the RECTUM or both. Risk factors for colorectal cancer include chronic ULCERATIVE COLITIS; FAMILIAL POLYPOSIS COLI; exposure to ASBESTOS; and irradiation of the CERVIX UTERI.
Phase of the CELL CYCLE following G1 and preceding G2 when the entire DNA content of the nucleus is replicated. It is achieved by bidirectional replication at multiple sites along each chromosome.
The number of males and females in a given population. The distribution may refer to how many men or women or what proportion of either in the group. The population is usually patients with a specific disease but the concept is not restricted to humans and is not restricted to medicine.
Substances that reduce the growth or reproduction of BACTERIA.
One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.
Procedures for finding the mathematical function which best describes the relationship between a dependent variable and one or more independent variables. In linear regression (see LINEAR MODELS) the relationship is constrained to be a straight line and LEAST-SQUARES ANALYSIS is used to determine the best fit. In logistic regression (see LOGISTIC MODELS) the dependent variable is qualitative rather than continuously variable and LIKELIHOOD FUNCTIONS are used to find the best relationship. In multiple regression, the dependent variable is considered to depend on more than a single independent variable.
Pathological processes that tend eventually to become malignant. (From Dorland, 27th ed)
The period of the CELL CYCLE preceding DNA REPLICATION in S PHASE. Subphases of G1 include "competence" (to respond to growth factors), G1a (entry into G1), G1b (progression), and G1c (assembly). Progression through the G1 subphases is effected by limiting growth factors, nutrients, or inhibitors.
The fission of a CELL. It includes CYTOKINESIS, when the CYTOPLASM of a cell is divided, and CELL NUCLEUS DIVISION.
The ratio of two odds. The exposure-odds ratio for case control data is the ratio of the odds in favor of exposure among cases to the odds in favor of exposure among noncases. The disease-odds ratio for a cohort or cross section is the ratio of the odds in favor of disease among the exposed to the odds in favor of disease among the unexposed. The prevalence-odds ratio refers to an odds ratio derived cross-sectionally from studies of prevalent cases.
Clarity or sharpness of OCULAR VISION or the ability of the eye to see fine details. Visual acuity depends on the functions of RETINA, neuronal transmission, and the interpretative ability of the brain. Normal visual acuity is expressed as 20/20 indicating that one can see at 20 feet what should normally be seen at that distance. Visual acuity can also be influenced by brightness, color, and contrast.
Research aimed at assessing the quality and effectiveness of health care as measured by the attainment of a specified end result or outcome. Measures include parameters such as improved health, lowered morbidity or mortality, and improvement of abnormal states (such as elevated blood pressure).
A vital statistic measuring or recording the rate of death from any cause in hospitalized populations.
Tumors or cancer located in bone tissue or specific BONES.
A detailed review and evaluation of selected clinical records by qualified professional personnel for evaluating quality of medical care.
Agents that suppress immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-CELLS or by inhibiting the activation of HELPER CELLS. While immunosuppression has been brought about in the past primarily to prevent rejection of transplanted organs, new applications involving mediation of the effects of INTERLEUKINS and other CYTOKINES are emerging.
The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment.
Pathological processes of the KIDNEY or its component tissues.
A statistical technique that isolates and assesses the contributions of categorical independent variables to variation in the mean of a continuous dependent variable.
In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.
Tumors or cancer of the STOMACH.
Laboratory mice that have been produced from a genetically manipulated EGG or EMBRYO, MAMMALIAN.
Hospital units providing continuous surveillance and care to acutely ill patients.
A parliamentary democracy with a constitutional monarch in southeast Asia, consisting of 11 states (West Malaysia) on the Malay Peninsula and two states (East Malaysia) on the island of BORNEO. It is also called the Federation of Malaysia. Its capital is Kuala Lumpur. Before 1963 it was the Union of Malaya. It reorganized in 1948 as the Federation of Malaya, becoming independent from British Malaya in 1957 and becoming Malaysia in 1963 as a federation of Malaya, Sabah, Sarawak, and Singapore (which seceded in 1965). The form Malay- probably derives from the Tamil malay, mountain, with reference to its geography. (From Webster's New Geographical Dictionary, 1988, p715 & Room, Brewer's Dictionary of Names, 1992, p329)
Liver disease in which the normal microcirculation, the gross vascular anatomy, and the hepatic architecture have been variably destroyed and altered with fibrous septa surrounding regenerated or regenerating parenchymal nodules.
A type of CELL NUCLEUS division by means of which the two daughter nuclei normally receive identical complements of the number of CHROMOSOMES of the somatic cells of the species.
The use of internal devices (metal plates, nails, rods, etc.) to hold the position of a fracture in proper alignment.
A republic in western Africa, south of NIGER between BENIN and CAMEROON. Its capital is Abuja.
The determination of the pattern of genes expressed at the level of GENETIC TRANSCRIPTION, under specific circumstances or in a specific cell.
Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.
The age of the conceptus, beginning from the time of FERTILIZATION. In clinical obstetrics, the gestational age is often estimated as the time from the last day of the last MENSTRUATION which is about 2 weeks before OVULATION and fertilization.
A procedure in which a laparoscope (LAPAROSCOPES) is inserted through a small incision near the navel to examine the abdominal and pelvic organs in the PERITONEAL CAVITY. If appropriate, biopsy or surgery can be performed during laparoscopy.
A graphic means for assessing the ability of a screening test to discriminate between healthy and diseased persons; may also be used in other studies, e.g., distinguishing stimuli responses as to a faint stimuli or nonstimuli.
Extensive collections, reputedly complete, of facts and data garnered from material of a specialized subject area and made available for analysis and application. The collection can be automated by various contemporary methods for retrieval. The concept should be differentiated from DATABASES, BIBLIOGRAPHIC which is restricted to collections of bibliographic references.
Complications that affect patients during surgery. They may or may not be associated with the disease for which the surgery is done, or within the same surgical procedure.
The genetic constitution of the individual, comprising the ALLELES present at each GENETIC LOCUS.
Proteins whose abnormal expression (gain or loss) are associated with the development, growth, or progression of NEOPLASMS. Some neoplasm proteins are tumor antigens (ANTIGENS, NEOPLASM), i.e. they induce an immune reaction to their tumor. Many neoplasm proteins have been characterized and are used as tumor markers (BIOMARKERS, TUMOR) when they are detectable in cells and body fluids as monitors for the presence or growth of tumors. Abnormal expression of ONCOGENE PROTEINS is involved in neoplastic transformation, whereas the loss of expression of TUMOR SUPPRESSOR PROTEINS is involved with the loss of growth control and progression of the neoplasm.
Theoretical representations that simulate the behavior or activity of biological processes or diseases. For disease models in living animals, DISEASE MODELS, ANIMAL is available. Biological models include the use of mathematical equations, computers, and other electronic equipment.
Criteria and standards used for the determination of the appropriateness of the inclusion of patients with specific conditions in proposed treatment plans and the criteria used for the inclusion of subjects in various clinical trials and other research protocols.
The period following a surgical operation.
Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS.
A country spanning from central Asia to the Pacific Ocean.
A pathologic process consisting of the proliferation of blood vessels in abnormal tissues or in abnormal positions.
An appreciable lateral deviation in the normally straight vertical line of the spine. (Dorland, 27th ed)
Damage inflicted on the body as the direct or indirect result of an external force, with or without disruption of structural continuity.
Body organ that filters blood for the secretion of URINE and that regulates ion concentrations.
Methods which attempt to express in replicable terms the level of CELL DIFFERENTIATION in neoplasms as increasing ANAPLASIA correlates with the aggressiveness of the neoplasm.
A country in northern Africa between ALGERIA and LIBYA. Its capital is Tunis.
Cells grown in vitro from neoplastic tissue. If they can be established as a TUMOR CELL LINE, they can be propagated in cell culture indefinitely.
The relationship between the dose of an administered drug and the response of the organism to the drug.
A partial or complete return to the normal or proper physiologic activity of an organ or part following disease or trauma.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).
The age, developmental stage, or period of life at which a disease or the initial symptoms or manifestations of a disease appear in an individual.
The probability that an event will occur. It encompasses a variety of measures of the probability of a generally unfavorable outcome.
Removal and examination of tissue obtained through a transdermal needle inserted into the specific region, organ, or tissue being analyzed.
Incorrect diagnoses after clinical examination or technical diagnostic procedures.
Studies in which the presence or absence of disease or other health-related variables are determined in each member of the study population or in a representative sample at one particular time. This contrasts with LONGITUDINAL STUDIES which are followed over a period of time.
Mutant mice homozygous for the recessive gene "nude" which fail to develop a thymus. They are useful in tumor studies and studies on immune responses.
The study of chance processes or the relative frequency characterizing a chance process.
Care given during the period prior to undergoing surgery when psychological and physical preparations are made according to the special needs of the individual patient. This period spans the time between admission to the hospital to the time the surgery begins. (From Dictionary of Health Services Management, 2d ed)
Research techniques that focus on study designs and data gathering methods in human and animal populations.
Nuclear phosphoprotein encoded by the p53 gene (GENES, P53) whose normal function is to control CELL PROLIFERATION and APOPTOSIS. A mutant or absent p53 protein has been found in LEUKEMIA; OSTEOSARCOMA; LUNG CANCER; and COLORECTAL CANCER.
The number of CD4-POSITIVE T-LYMPHOCYTES per unit volume of BLOOD. Determination requires the use of a fluorescence-activated flow cytometer.
Hospital department responsible for the administration and provision of immediate medical or surgical care to the emergency patient.
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.
The movement of cells from one location to another. Distinguish from CYTOKINESIS which is the process of dividing the CYTOPLASM of a cell.
Antibodies produced by a single clone of cells.
A therapeutic approach, involving chemotherapy, radiation therapy, or surgery, after initial regimens have failed to lead to improvement in a patient's condition. Salvage therapy is most often used for neoplastic diseases.
The transference of a kidney from one human or animal to another.
The transference of a part of or an entire liver from one human or animal to another.
Soft tissue tumors or cancer arising from the mucosal surfaces of the LIP; oral cavity; PHARYNX; LARYNX; and cervical esophagus. Other sites included are the NOSE and PARANASAL SINUSES; SALIVARY GLANDS; THYROID GLAND and PARATHYROID GLANDS; and MELANOMA and non-melanoma skin cancers of the head and neck. (from Holland et al., Cancer Medicine, 4th ed, p1651)
The systems and processes involved in the establishment, support, management, and operation of registers, e.g., disease registers.
Procedures used to treat and correct deformities, diseases, and injuries to the MUSCULOSKELETAL SYSTEM, its articulations, and associated structures.
Procedures of applying ENDOSCOPES for disease diagnosis and treatment. Endoscopy involves passing an optical instrument through a small incision in the skin i.e., percutaneous; or through a natural orifice and along natural body pathways such as the digestive tract; and/or through an incision in the wall of a tubular structure or organ, i.e. transluminal, to examine or perform surgery on the interior parts of the body.
Immunologic techniques based on the use of: (1) enzyme-antibody conjugates; (2) enzyme-antigen conjugates; (3) antienzyme antibody followed by its homologous enzyme; or (4) enzyme-antienzyme complexes. These are used histologically for visualizing or labeling tissue specimens.
The introduction of a phosphoryl group into a compound through the formation of an ester bond between the compound and a phosphorus moiety.
Drug therapy given to augment or stimulate some other form of treatment such as surgery or radiation therapy. Adjuvant chemotherapy is commonly used in the therapy of cancer and can be administered before or after the primary treatment.
Fractures of the upper jaw.
The practice of sending a patient to another program or practitioner for services or advice which the referring source is not prepared to provide.
Damage or trauma inflicted to the eye by external means. The concept includes both surface injuries and intraocular injuries.
Tumors or cancer of the ESOPHAGUS.
The presence of viable bacteria circulating in the blood. Fever, chills, tachycardia, and tachypnea are common acute manifestations of bacteremia. The majority of cases are seen in already hospitalized patients, most of whom have underlying diseases or procedures which render their bloodstreams susceptible to invasion.
Tumors or cancer of the URINARY BLADDER.
Antibodies from non-human species whose protein sequences have been modified to make them nearly identical with human antibodies. If the constant region and part of the variable region are replaced, they are called humanized. If only the constant region is modified they are called chimeric. INN names for humanized antibodies end in -zumab.
A surgical operation for the relief of pressure in a body compartment or on a body part. (From Dorland, 28th ed)
A negative regulatory effect on physiological processes at the molecular, cellular, or systemic level. At the molecular level, the major regulatory sites include membrane receptors, genes (GENE EXPRESSION REGULATION), mRNAs (RNA, MESSENGER), and proteins.
A positive regulatory effect on physiological processes at the molecular, cellular, or systemic level. At the molecular level, the major regulatory sites include membrane receptors, genes (GENE EXPRESSION REGULATION), mRNAs (RNA, MESSENGER), and proteins.
Tumors or cancer of the MOUTH.
Technique using an instrument system for making, processing, and displaying one or more measurements on individual cells obtained from a cell suspension. Cells are usually stained with one or more fluorescent dyes specific to cell components of interest, e.g., DNA, and fluorescence of each cell is measured as it rapidly transverses the excitation beam (laser or mercury arc lamp). Fluorescence provides a quantitative measure of various biochemical and biophysical properties of the cell, as well as a basis for cell sorting. Other measurable optical parameters include light absorption and light scattering, the latter being applicable to the measurement of cell size, shape, density, granularity, and stain uptake.
Tumors or cancer of the UTERINE CERVIX.
Tumors or cancers of the KIDNEY.
Systems for assessing, classifying, and coding injuries. These systems are used in medical records, surveillance systems, and state and national registries to aid in the collection and reporting of trauma.
The visualization of tissues during pregnancy through recording of the echoes of ultrasonic waves directed into the body. The procedure may be applied with reference to the mother or the fetus and with reference to organs or the detection of maternal or fetal disease.
Therapeutic act or process that initiates a response to a complete or partial remission level.
An anatomic severity scale based on the Abbreviated Injury Scale (AIS) and developed specifically to score multiple traumatic injuries. It has been used as a predictor of mortality.
Studies to determine the advantages or disadvantages, practicability, or capability of accomplishing a projected plan, study, or project.
A group of enzymes that catalyzes the phosphorylation of serine or threonine residues in proteins, with ATP or other nucleotides as phosphate donors.
A benign epithelial tumor with a glandular organization.
A study to evaluate the association between germline genetic variation and disease risk and outcome in ovarian carcinoma in ... The role of p53 mutations in the development, progression and outcome of breast cancer in Pakistan. Genetic causes of ... Tumor virology Human Papillomavirus Associated with Esophageal Cancer in Pakistan - A Retrospective Analysis. Human ... At the moment such studies are limited in Pakistan. SKMCH&RC's research is organized in three streams: epidemiology, which ...
Researchers have put together retrospective data collections in order to better under the progression of this orphan disease. ... Most studies show a perinatal period marked by inadequacy of the ANS to control blood pressure, blood sugar, and body ... L-DOPS continues to be studied pharmacologically and pharmacokinetically and shows an ability to increase the levels of central ... dose-ranging study in multiple system atrophy and pure autonomic failure". Clinical Autonomic Research. 11 (4): 235-242. doi: ...
... legal case progression, and outcomes in South African rape cases: retrospective review". PLoS Medicine. 6 (10): e1000164. doi: ... A UN-sponsored study coauthored by Jewkes on male violence against women in Asia and the Pacific reported that a high number of ... Shea, Rachel (14 September 2013). "UN Study Looks at High Rate of Rape". Retrieved 12 November 2014. "Almost a quarter of men ' ... Survey researchers have questioned the plausibility of some of the findings of this study. In 2013 Jewkes also published on ...
A retrospective study on 1054 patients with anaplastic oligodendroglioma, presented during the 2009 ASCO Annual Meeting, ... Median time to progression for patients with 1p19q co-deletion was longer following PCV alone (7.6 years) than with ... Recent studies suggest that radiation does not improve overall survival (even when age, clinical data, histological grading, ... It is possible that radiotherapy may prolong the overall time to progression for non-deleted tumors. If the tumor mass ...
In a retrospective study on 43 patients, 63% of patients were found to have no growth on follow-up, and the 37% found to have ... atypical and anaplastic meningiomas identifies novel genes associated with meningioma progression". Int. J. Cancer. 114 (2): ... a retrospective study". International Journal of Radiation Oncology, Biology, Physics. 46 (1): 57-61. doi:10.1016/S0360-3016(99 ... Numerous retrospective studies, however, have suggested strongly that the addition of postoperative radiation to incomplete ...
A retrospective study of patients treated with resection, chemotherapy and autologus hematopoietic stem cell transplantation ... and 5-year disease progression-free survival from 22 to 52%. While further studies, particularly randomized controlled trials, ... a second retrospective study supported the usefulness of transplantation in that high-dose lymphoma chemotherapy followed by ... Further studies are required to determine which, if any, of these genetic abnormalities play a role in the development and/or ...
A retrospective study of 167 patients with RA-ILD determined that the usual interstitial pneumonia (UIP) pattern on high- ... elevated lactate dehydrogenase closely correlated with ILD.Recent studies have identified risk factors for disease progression ... A recently published retrospective study by a team from Beijing Chao-Yang Hospital in Beijing, China, supported three of the ... A study of 59 RA-ILD patients found no median survival difference between those with the UIP pattern and those without it. But ...
... some studies have identified strenuous exercise as a novel risk for accelerated progression of the disease. One retrospective ... Novel studies showed that mutations (point mutations) in genes encoding for desmosomal proteins (see intercalated disc) are the ... The prevalence of ACM is about 1/10,000 in the general population in the United States, although some studies have suggested ... While angiotensin converting enzyme inhibitors (ACE Inhibitors) are well known for slowing progression in other ...
Stella's retrospective exhibition inspired Kass to become an artist as she observed and understood the logic in his progression ... and studied at the Whitney Museum Independent Study Program Here, she created her first work of appropriation, Ophelia's Death ... a retrospective" (catalogue) (1996) Jose Freire Fine Art, New York, NY, "My Andy: a retrospective" Arthur Roger Gallery, New ... She used Warhol's visual language to comment on the absence of women in art history at the same time that Women's Studies began ...
In the SIRFLOX study, better progression-free survival was also not observed. These trials did not result in direct evidence ... Retrospective, Propensity Score-Matched Study". Journal of Vascular and Interventional Radiology. 28 (6): 777-785.e1. doi: ... such as longer time to progression, higher complete response rates and longer progression-free survival. There are currently ... More studies and cohort analyses are underway to evaluate subgroups of patients that benefit from SIRT as a first-line or later ...
This offers a dual approach to both seeing trends in retrospective studies and using biomarkers to predict outcomes. For ... Mutations in mitochondrial DNA have been shown to correlate to risk, progression, and treatment response of head and neck ... Ecotoxicologial studies could be considered the precursors to biomarker studies.[22] Biomarkers are used to indicate an ... The biologic rationale of a study must be assessed on a small scale before any large scale studies can occur.[15] Many ...
The ADOPT study showed that initial therapy with drugs of this type may prevent the progression of disease, as did the DREAM ... Multiple retrospective studies have resulted in a concern about rosiglitazone's safety, although it is established that the ... Safety studies are continuing. In contrast, at least one large prospective study, PROactive 05, has shown that pioglitazone may ... Gallwitz (2006). "Exenatide in type 2 diabetes: treatment effects in clinical studies and animal study data". International ...
Some studies have linked oligodendroglioma with a viral cause. A 2009 Oxford Neurosymposium study illustrated a 69% correlation ... 2002). "(Abstract) Impact of duration of temozolomide therapy on progression-free survival in recurrent malignant glioma". ... "Retrospective analysis of outcomes among more than 1,000 patients with newly diagnosed anaplastic oligodendroglial tumors". ... In one study, classic oligodendrogliomas showed 1p loss in 35 of 42 (83%) cases, 19q loss in 28 of 39 (72%), and these were ...
She began a study of the history of painting and "went through a progression of spatial conceptions" from cave painting through ... The 1975 Yoseloff retrospective catalogue listed below is very illuminating on these latter developments, and the color plates ... She studied with artists, Hans Hofmann and Norman Carlberg. Jane Frank was a pupil of the painter, Hans Hofmann.[citation ... In New York, she also studied at the New Theatre School. Her schooling complete, she began working in advertising design and ...
Pre-clinical studies indicate that the compound acts as an activator of the Nrf2 pathway and an inhibitor of the NF-κB pathway ... A retrospective post-hoc analyses of the Phase 3 data, conducted by Reata, identified prior hospitalization for heart failure ... A Phase 3 multinational RCT (BEACON) designed to test the effect of bardoxolone methyl on progression to end-stage renal ... In 2014, Reata announced the initiation of a placebo-controlled, multicenter Phase 2 study (LARIAT), to assess the effects of ...
... a retrospective analysis of two randomised radiotherapy trials and one surgical cohort study". The Lancet. Oncology. 9 (4): 342 ... During cancer progression, tumor cells acquire comprehensive metabolic reprogramming, and tissue hypoxia is a prominent feature ... The study of tumors in such conditions was pioneered by Dr L. H. Gray. An association between tumor hypoxia and metastatic ... "Safety and Efficacy Study of Trans Sodium Crocetinate (TSC) With Concomitant Radiation Therapy and Temozolomide in Newly ...
A retrospective study of patients treated with SRT between 1987 and 2013 found that 56% of 2460 patients were free from ... The risk of disease progression and metastasis (spread of the cancer) may be increased, but this increase risk appears to be ... However, a recent retrospective study suggests that men under 60 with high grade prostate cancer have higher survival rates ... Other studies showed no difference of robotic to open surgery. A review comprehensively analyzed the evidence from studies in ...
A retrospective 16-year study in south India". Indian Journal of Medical and Paediatric Oncology. 30 (4): 131-135. doi:10.4103/ ... Given this, the aforementioned 28% atypia progression rate may be an underestimate, and the true number may closer to the 42.5 ... A retrospective 16-year study in south India". Indian Journal of Medical and Paediatric Oncology. 30 (4): 131-135. doi:10.4103/ ... A long-term study of "untreated" hyperplasia in 170 patients". Cancer. 56 (2): 403-12. doi:10.1002/1097-0142(19850715)56:2. 3.0 ...
... according to a retrospective, matched-cohort study. The prospective cohorts were matched to the retrospective cohorts according ... and should aim to both prevent progression of the curve (prevent progression to surgery), as well as reduce the scoliosis curve ... This study's results may be biased due to the pedicle screw group's being analyzed prospectively versus retrospective analysis ... Recent studies in healthcare have led to the development of a variety of treatments to assist in the management of scoliosis ...
In another retrospective review of the anime X, Beverdige-now writing for Fandom Post-regarded Kamui's and Fūma's relationship ... Cavallaro, Dani (2012). CLAMP in Context: A Critical Study of the Manga and Anime. McFarland. p. 185. ISBN 978-0786469543. "X, ... Maruyama also praised Seki's work as Kamui alongside Kōhei Kiyasu's from Hajime no Ippo for presenting a natural progression in ... Cavallaro, Dani (2012). CLAMP in Context: A Critical Study of the Manga and Anime. McFarland. ISBN 978-0786469543. Archived ...
... retrospective multicohort study". The Lancet. Oncology. 19 (9): 1180-1191. doi:10.1016/S1470-2045(18)30413-3. PMID 30120041. ... November 2018). "Distinguishing True Progression From Radionecrosis After Stereotactic Radiation Therapy for Brain Metastases ... Radiomic studies have shown that image-based markers have the potential to provide information orthogonal to staging and ... Other studies have also demonstrated the utility of radiomics for predicting immunotherapy response of NSCLC patients using pre ...
Zhang serves as the principal investigator of the diabetes and women's health study, which is a retrospective cohort study of ... for the progression from gestational diabetes to type 2 diabetes and its complications and the investigation of biochemical ... The study confirms the links between gestational diabetes and cardiovascular disease found by other studies. It also provides ... A study Zhang led found that women who have had gestational diabetes may be able to reduce or even eliminate their elevated ...
No randomized study in medical literature has studied the response with amputation of patients who have failed the above- ... In a retrospective cohort (unblinded, non-randomised and with intention-to-treat) of fifty patients diagnosed with CRPS, the ... "poorer clinical pain outcomes and show persistent signs of central sensitisation correlating with disease progression". Vitamin ... In addition, some studies have indicated that cigarette smoking was strikingly present in patients and is statistically linked ...
Progression from Part II of the Mathematical Tripos to Part III normally requires either a first in Part II or very good ... The first retrospective M.Math and M.A.St. degrees were conferred as part of a celebration of the University's 800th ... Roughly one third of the students take the course as a fourth year of mathematical study at Cambridge (after Parts IA, IB, and ... The Smith's Prize Examination was founded by bequest of Robert Smith upon his death in 1768 to encourage the study of more ...
This offers a dual approach to both seeing trends in retrospective studies and using biomarkers to predict outcomes. For ... Mutations in mitochondrial DNA have been shown to correlate to risk, progression, and treatment response of head and neck ... In this case, the lack of data beyond retrospective studies and successful biomarker-driven approaches was suggested to be ... The manner in which the environment was monitored and studied near the end of the 1980s was still mainly reliant on the study ...
In one retrospective study, 19 of 23 patients with CD4+ ITCLD-GT had persistent disease over a follow-up period of 1-14 years ( ... GI tract endoscopic examinations and PET scans in order to detect the progression of ITCLD-GT to a malignant phase. Studies to ... In a recent study, the T cells in 4 of 5 patients with CD4+ T-cell disease carried a STAT3-JAK2 fusion gene. This gene consists ... In the same study, 10 of 10 patients with CD8+ ITCLD-GT had persistent disease that had not progressed to a malignancy over an ...
A 2006 retrospective study, with long clinical follow-up, was made of colon cancer patients treated with the topoisomerase ... Although treatments using synthetic lethality can stop or slow progression of cancers and prolong survival, each of the ... Pre-clinical studies in cells and in mice show that synthetic lethality for deficient ARID1A expression occurs by either ... Pre-clinical studies, involving epigenetically reduced or mutated BRCA-deficient cells (in culture or injected into mice), show ...
These studies reveal the artist's developing style, characterised by the flow and economy of line as well as a sense of ... The artist recorded his physiognomic progression and experiences through the painted self-portraits. As a result, the depicted ... Fiorentino, Emmanuel (1999). Antoine Camilleri: A Retrospective Exhibition. Bank of Valletta plc. p. 2. Agius, Joseph (22 March ... In 1948 and with the help of his father, Antoine went to study at the École Superieure des Beaux Arts in Paris. There he came ...
This line of study was extended by his son, Richard S. Handley, who studied internal mammary chain nodal involvement in breast ... This increasingly radical progression culminated in the 'super-radical' mastectomy which consisted of complete excision of all ... After retrospective analysis, the extended radical mastectomies were abandoned as these massive and disabling operations proved ... Fitts WT, Keuhnelian JG, Ravdin IS, Schor S (March 1954). "Swelling of the arm after radical mastectomy; a clinical study of ...
... a meta-analysis of retrospective cohort studies". Chinese Medical Journal. 125 (23): 4301-6. PMID 23217404.. ... with diabetes and albuminuria should receive an inhibitor of the renin-angiotensin system to reduce the risks of progression to ... Update to a position statement of the American Diabetes Association and the European Association for the Study of Diabetes". ... a meta-analysis of prospective cohort studies". Diabetes Research and Clinical Practice. 89 (3): 309-19. doi:10.1016/j.diabres. ...
"One million haemopoietic stem-cell transplants: a retrospective observational study". Lancet Haematol. 2015 Mar 2(3): e91-100. ... halt further progression, and reduce the burden of disability in some patients" that have aggressive highly active MS, "in the ... A study involving 2408 donors (18-60 years) indicated that bone pain (primarily back and hips) as a result of filgrastim ... A study that surveyed 2408 donors found that serious adverse events (requiring prolonged hospitalization) occurred in 15 donors ...
... a retrospective, matched cohort study". Br J Clin Pharmacol. doi:10.1111/bcp.13152. PMID 27735065.. ... Androgens like testosterone and particularly DHT are importantly involved in the development and progression of prostate cancer ... Study of the specificity". Journal of Steroid Biochemistry. 7 (5): 335-343. doi:10.1016/0022-4731(76)90092-3. ISSN 0022-4731.. ... a study found that treatment with a relatively low dosage of 20 μg/day ethinylestradiol for 5 weeks increased circulating SHBG ...
Womack, Kenneth; Davis, Todd F. (2012). Reading the Beatles: Cultural Studies, Literary Criticism, and the Fab Four. SUNY Press ... Harrison wrote the chord progression of "Don't Bother Me" almost exclusively in the Dorian mode, demonstrating an interest in ... a retrospective of the Beatles' career, earned two MTV Music Video Awards nominations in 1988.[159] Recorded at his estate in ... Harrison studied the instrument until 1968, when, following a discussion with Shankar about the need to find his "roots", an ...
Soccer was identified as a possible risk factor for ALS in a retrospective cohort study of 24,000 Italian soccer players who ... Progression[edit]. Although the initial symptoms and rate of progression vary from person to person, the disease eventually ... A 2012 retrospective cohort study of 3,439 former NFL players found that their risk of dying from neurodegenerative causes was ... A 2016 review found the evidence inconclusive and noted that differences in study design make it difficult to compare studies, ...
... a retrospective, cohort-based study". The Lancet. Oncology. 18 (2): 202-211. doi:10.1016/S1470-2045(16)30648-9. PMID 27993569. ... Studies found, for example, that the IQ of 5 year old children declined each year after treatment by several IQ points.[21]. ... One fractionation schedule that is increasingly being used and continues to be studied is hypofractionation. This is a ... Newer research approaches are currently being studied, including preclinical and clinical investigations into the use of an ...
Thus, the method is called "swim, float, swim." In a 2009 retrospective case-control study that involved significant potential ... 8 (2): 113-4. The Diving Reflex - Infant Babies Swimming Underwater on YouTube Infant Swimming Resource: Teaching Progression ... Another study showed that infant swimming lessons may improve motor skills, but the number of study subjects was too low to be ... A Centers for Disease Control and Prevention study in 2012 of United States data from 2005-2009 indicated that each year an ...
... a retrospective study of 159 cases in Reunion Island from 2006-2012". PLOS Neglected Tropical Diseases. 9 (3): e0003603. doi: ... June 2010). "Clinical progression of chikungunya fever during acute and chronic arthritic stages and the changes in joint ... Studies in animals using passive immunotherapy have been effective, and clinical studies using passive immunotherapy in those ... Viral replication is highly cytopathic, but susceptible to type-I and -II interferon.[43] In vivo, in studies using living ...
A Retrospective Cross-Sectional Study of Retraction Notices at BioMed Central". BMJ Open. 6 (11): e012047. doi:10.1136/bmjopen- ... due to the association of publication with career progression (publish or perish/publication pressure), and the time ... Various studies have investigated the extent of open access. A study published in 2010 showed that roughly 20% of the total ... the authors of the study stated that all NFL players were part of a study, a claim that the reporters found to be false by ...
Retrospective diagnosis. The labeling of an illness in a historical figure or specific historical event using modern knowledge ... Diagnosis problems are the dominant cause of medical malpractice payments, accounting for 35% of total payments in a study of ... progression, prognosis, other outcomes, and possible treatments of her or his ailments, as well as providing advice for ... A diagnosis based primarily on the results from medical imaging studies. Greenstick fractures are common radiological diagnoses ...
Stockholm studies in archaeology 57 (2012): 187-208. *^ Härke, Heinrich. "Grave goods in early medieval burials: messages and ... "retrospective reworking" of kinship ties to the dominant group led, ultimately, to the "myths which tied the entire society to ... considered the development of kingdoms and writing down of the oral law-codes to be linked to a progression towards leaders ... John Hines, Karen Høilund Nielsen, Frank Siegmund, The Pace of Change: Studies in Early-Medieval Chronology, Oxbow Books, 1999 ...
A 2003 study of bereaved individuals conducted by Maciejewski and colleagues at Yale University obtained some findings ... Later in her life, Kübler-Ross noted that the stages are not a linear and predictable progression and that she regretted ... People dying may precede the survivors in this state, which typically comes with a calm, retrospective view for the individual ... the model postulates a progression of emotional states experienced by terminally ill patients after diagnosis. The five stages ...
Crick, Francis Harry Compton (1954). Polypeptides and proteins : X-ray studies. (PhD thesis). University ... Importantly, the lectureship is aimed at younger scientists, ideally under 40, or whose career progression corresponds to this ... In a retrospective article,[102] Crick and Orgel noted that they had been overly pessimistic about the chances of abiogenesis ... Olby, Robert (1970). "The Making of Modern Science: Biographical Studies". Journal of the American Academy of Arts and Sciences ...
... a retrospective multicenter study". Gastroenterology. 122 (4): 923-30. doi:10.1053/gast.2002.32364. PMID 11910344.. ... In contrast, type 2 HRS is slower in onset and progression, and is not associated with an inciting event. It is defined by an ... Clinical pathological and experimental studies". Surg Gynecol Obstet. 55: 570-80.. *^ Hecker R, Sherlock S (December 1956). " ... Results of a randomized study". Gastroenterology. 93 (2): 234-41. doi:10.1016/0016-5085(87)91007-9. PMID 3297907.. ...
... a case-control and retrospective cross-sectional MRI study at 3T". PLOS One. 9 (4): e93814. Bibcode:2014PLoSO...993814S. doi: ... Schematic initial progression of Lewy body deposits in the first stages of Parkinson's disease, as proposed by Braak and ... Maria, Nord (2017). Levodopa pharmacokinetics -from stomach to brain A study on patients with Parkinson's disease. Linköping: ... Some studies in humans have shown a correlation between patterns of dysbiosis in the gut flora in the people with PD, and these ...
Of particular note are two recent studies from Lynette Hart's lab at UC Davis. The first study from 2013, published in a well- ... Testosterone in intact males is thought to slow the progression of cognitive impairment, at least in dogs that already have ... a retrospective analysis of 54 cases". Veterinary Record. 139: 542-6. doi:10.1136/vr.139.22.542.. ... the study recommended that female dogs be spayed no earlier than 3 to 4 months of age.[25] A later study comparing female dogs ...
Recent study shows that LH via a PKA signaling pathway regulates the phosphorylation and localization of DRP1 within ... By biological stage may be used in closely monitored menstrual cycles in regard to other markers of its biological progression ... "Hirsutism, virilism, polycystic ovarian disease, and the steroid-gonadotropin-feedback system: a career retrospective" ... evidence from the tandem study of normal and gonadotropin-releasing hormone-deficient men". The Journal of Clinical ...
... retrospective study using Millennium Cohort". BMC Public Health. 7: 81. doi:10.1186/1471-2458-7-81. PMC 1884144. PMID 17506887. ... "Smoking is associated with progression of diabetic nephropathy". Diabetes Care. 17 (2): 126-31. doi:10.2337/diacare.17.2.126. ... Case-control studies were published in Germany in 1939 and 1943, and one in the Netherlands in 1948. A case-control study on ... The British Doctors Study, a longitudinal study of some 40,000 doctors, began in 1951.[18] By 1954 it had evidence from three ...
A retrospective general dental practice based study from northern England. British Dental Journal, 193(2), 99-103. doi:10.1038/ ... in deciduous teeth some clinician may choose to leave the tooth to monitor progression and wait for further caries progression ... This problem has not been realised with one study showing long-term data beyond 5 years, to when the baby teeth are lost, with ... a retrospective analysis Brit Dent J 2006; 200(8):451-4 & 444 ...
This was based on animal studies and retrospective observational studies. However, large scale prospective studies have failed ... The polyp to cancer progression sequence is the classical model of colorectal cancer pathogenesis.[48] The polyp to cancer ... study and a recent meta-analysis. The variation in findings from prospective studies needs to be better understood; dietary ... FIT-DNA has more false positives than FIT and thus results in more adverse effects.[5] Further study is required as of 2016 to ...
There is no known cure, but medication may slow the progression so that a normal lifespan and quality of life may be attainable ... Specific treatment for fatigue, which may be debilitating in some patients, is limited and undergoing trials.[38] Some studies ... 2014). "Predictive Scores in Primary Biliary Cirrhosis: A Retrospective Single Center Analysis of 204 Patients". Journal of ... Other drugs that are undergoing clinical studies in UDCA non-responders include fibrates, such as fenofibrate and bezafibrate, ...
John Rewald, (1986). Studies in Post-Impressionism, Paul Gauguin-Letters to Ambroise Vollard and Andre Fontainas, 168-215. ... Thomson observes a progression in complexity.[167] Mathews notes a return to Christian symbolism that would have endeared him ... Gauguin's posthumous retrospective exhibitions at the Salon d'Automne in Paris in 1903 and an even larger one in 1906 had a ... Rewald, John (1986). Studies in Post-Impressionism. Harry N. Abrams Inc.. *Richardson, John (1991). A Life of Picasso, The ...
Retrospective cohort study". BMJ. 338: a2752. doi:10.1136/bmj.a2752. PMC 2615549. PMID 19129307.. ... Progression of CKD towards end stage renal disease requiring renal replacement therapy is accompanied by increasing prevalence ... Widespread study of physical and mental pathology found its place in psychiatry. I. Jensen (1975),[18] J.H. Boyd (1984),[19] W. ... A study of inpatient hospital data in the United States in 2011 showed that the presence of a major complication or comorbidity ...
... a retrospective study". Journal of Cutaneous and Aesthetic Surgery. 4 (1): 12-16. doi:10.4103/0974-2077.79180. PMC 3081477 . ... although it oversimplified the topological progression of neighboring collagen molecules, and hence did not predict the correct ... A Retrospective Study". Cutaneous and Aesthetic Surgery. 4 (1): 12-16. doi:10.4103/0974-2077.79180. PMC 3081477 . PMID 21572675 ... Collagen is used in laboratory studies for cell culture, studying cell behavior and cellular interactions with the ...
Sir Rudolf Virchow, a German biologist and politician, studied microscopic pathology, and linked his observations to illness. ... Lopes, Ademar; Rossi, Benedito Mauro; Silveira, Claudio Regis Sampaio; Alves, Antonio Correa (1996). "Chordoma: retrospective ... Evolutionary Studies; Geosciences, School of; Witwatersrand, University of the; Africa, South; Medicine, De Busk College of ... Evolutionary Studies; Geosciences, School of; Witwatersrand, University of the; Africa, South; Sciences, School of Forensic and ...
In another study, two of five evaluable patients developed moderate gynecomastia with mild tenderness at four and eight weeks ... Bolignano D, Palmer SC, Navaneethan SD, Strippoli GF (April 2014). "Aldosterone antagonists for preventing the progression of ... A retrospective and literature review". Plastic and Reconstructive Surgery. 127 (1): 1-7. doi:10.1097/PRS.0b013e3181f9581c. ...
February 2017). "A genome-based model for adjusting radiotherapy dose (GARD): a retrospective, cohort-based study". The Lancet ... retrospective, cohort study". The Lancet. Oncology. 20 (5): 674-685. doi:10.1016/S1470-2045(18)30931-8. PMID 30885458.. ... Studies have found radiation therapy as the cause of secondary malignancies for only a small minority of patients.[20][21] New ... Studies found, for example, that the IQ of 5-year-old children declined each year after treatment by several IQ points.[28]. ...
In a study by Sudano and Baker, even intermittent loss of coverage has negative effects on healthy choices.[64] The potential ... A Retrospective Analysis of 28,729,765 U.S. Deliveries over 8 Years". American Journal of Perinatology. 29 (10): 787-794. doi: ... halting progression and complications from disease, and restoring the health and functions of the individuals affected by ... A 2004 study showed that about half of all deaths in the United States in 2000 were due to preventable behaviors and exposures. ...
A Natural History of the Progression of Stargardt Disease: Retrospective and Prospective Studies (ProgSTAR). This study has ... Visual Acuity Loss and Associated Risk Factors in the Retrospective Progression of Stargardt Disease Study (ProgStar Report No ... A concurrent ancillary study (SMART study) is also being conducted with a subset of the prospective study patients during their ... The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study ...
... Viraat Patel1, Joanna H. Tu2,3 and ... in a retrospective study [1,11].. The results of this study suggest pubertal hormones may not account for all of the risks in ... Our study demonstrates that patients who received no treatment were nearly three-fold more likely to experience progression ... Limitations of this study include potential confounding factors due to the retrospective design and lack of standardized ...
Obesity Progression Between Young Adulthood and Midlife and Incident Diabetes: A Retrospective Cohort Study of U.S. Adults ... Obesity Progression Between Young Adulthood and Midlife and Incident Diabetes: A Retrospective Cohort Study of U.S. Adults ... Obesity Progression Between Young Adulthood and Midlife and Incident Diabetes: A Retrospective Cohort Study of U.S. Adults ... Obesity Progression Between Young Adulthood and Midlife and Incident Diabetes: A Retrospective Cohort Study of U.S. Adults ...
Previous studies evaluating natural history of progression of AS shown that on average the rate of progression of Peak velocity ... Recently there is a growing interest in the field of Bone modifiers reducing progression of AS. In this study we aim to study ... Purpose Progression of Aortic Stenosis (AS) has been subject of much debate in the recent past with studies evaluating effects ... Conclusion Our study has shown that Osteoporotic patients on Bisphosphonate have significantly decreased progression of AS. ...
... ... This study investigated the association of HHcy with progression of IgA nephropathy. ...
ProgStar Study Group; Visual Acuity Loss in the Retrospective Natural History of the Progression of Atrophy Secondary to ... Visual Acuity Loss in the Retrospective Natural History of the Progression of Atrophy Secondary to Stargardt Disease (ProgStar- ... Visual Acuity Loss in the Retrospective Natural History of the Progression of Atrophy Secondary to Stargardt Disease (ProgStar- ... 1) Study Beatriz E Munoz; Xiangrong Kong; Rupert Wolfgang Strauss; Yulia Wolfson; Ann M Ervin; Sheila K West; Hendrik P Scholl ...
Control-matched surgical evaluation of endometriosis progression after IVF: a retrospective cohort study. Patrice CROCHET 1, ... Control-matched surgical evaluation of endometriosis progression after IVF: a retrospective cohort study. Minerva Ginecol 2016 ...
Control-matched surgical evaluation of endometriosis progression after IVF: a retrospective cohort study. Patrice CROCHET 1, ... Control-matched surgical evaluation of endometriosis progression after IVF: a retrospective cohort study. Minerva Ginecol 2016 ... METHODS: A retrospective case-control study set at the referral center for gynecologic endoscopy at Stanford University. Women ... of this study was to examine the surgical findings at repeated surgeries for endometriosis and to compare disease progression ...
A Retrospective Cohort Study. Manar Mohamd Mohamad Ismail1, Moneer M. Manar2. 1Laboratory Medicine Department, Faculty Of ... Does HOXA9 Gene Expression in Egyptian Chronic Myelogenous Leukemia Patients Affect Disease Progression? A Retrospective Cohort ... This study is an initial step to define the proportion of HOXA9 gene expression in some Egyptians with chronic-phase CML at ... Does HOXA9 Gene Expression in Egyptian Chronic Myelogenous Leukemia Patients Affect Disease Progression? ...
The purpose of this study was to clarify the features of the meniscal shape involved in the progression of knee OA. Data were ... scale progressed in 24 months from baseline and the other set consisted of 455 knees with no progression. The OA progressed ... In the progression of osteoarthritis (OA) of the knee, a correlation between meniscal posterior segment injuries and medial ... Stage-specific meniscal features predict progression of osteoarthritis of the knee: a retrospective cohort study using data ...
The clinical manifestation of mental disorder in Huntingtons disease: a retrospective case record study of disease progression ... The clinical manifestation of mental disorder in Huntingtons disease: a retrospective case record study of disease progression ... Anxiety Disorders, Depressive Disorder, Female, Follow-Up Studies, Humans, Huntington Disease, Male, Middle Aged, ...
We performed a retrospective analysis of the RN patients (The patients included in our study had a history of primary cancers ... Progression was identified when the increase of edema area ≥ 25% on the MRI taken in six months comparing with those taken at ... Percentage of progression was roughly three fold in hyponatremia patients compared with nonhyponatremia patients (53.1% versus ... We total included 135 patients, 32 (23.7%) of them with hyponatremia and 36 (26.7%) with RN progression. ...
Non-alcoholic fatty liver disease and progression of coronary artery calcium score: A retrospective cohort study. Gut. 2017 Feb ... Non-alcoholic fatty liver disease and progression of coronary artery calcium score : A retrospective cohort study. In: Gut. ... Non-alcoholic fatty liver disease and progression of coronary artery calcium score : A retrospective cohort study. / Sinn, Dong ... title = "Non-alcoholic fatty liver disease and progression of coronary artery calcium score: A retrospective cohort study", ...
Prognosis: Risk of progression (retrospective study) *Viral RNA load ,500. *Relative Risk of progression: 1.0 ...
Our study successfully differentiated high-risk cases among COVID-19 patients using imaging and clinical features. The ... Deep Learning Models for Predicting Severe Progression in COVID-19-Infected Patients: Retrospective Study Thao Thi Ho # 1 , ... Deep Learning Models for Predicting Severe Progression in COVID-19-Infected Patients: Retrospective Study Thao Thi Ho et al. ... Objective: The aim of this study is to develop deep learning models that can rapidly identify high-risk COVID-19 patients based ...
A retrospective study assessing ultrasonographic progression of canine biliary sludge (BS) over time - Recommend this title to ... A retrospective study assessing ultrasonographic progression of canine biliary sludge (BS) over time, Page 1 of 1 ... fA retrospective study assessing ultrasonographic progression of canine biliary sludge (BS) over time. ... A retrospective study assessing ultrasonographic progression of canine biliary sludge (BS) over time ...
Progression of cerebral venous thromboses. A retrospective study].. Rodier G, Schlück E, Derouiche F, Bronner P, Boulay C, ... Epidemiological, clinical, paraclinical and molecular study of a cohort of 102 patients affected with autosomal recessive ... Switching from natalizumab to fingolimod in multiple sclerosis: a French prospective study. ...
Time Perspective: Retrospective. *Progression of patients progression free. 1. Female. 18 Years and older (Adult, Senior). ... For Advanced Users: Full Study Record XML Download. *. a zip file of the full study records in XML for all studies in the ... Show studies that were first added (first posted) in the last 14 days. Show studies added or modified (last update posted) in ... To download the XML for all public study records in our database; See Downloading All Study Content for Analysis ...
Clinical characteristics and analysis of risk factors for disease progression of COVID-19: A retrospective Cohort Study ... A retrospective cohort study was conducted to summarize the clinical characteristics of patients with COVID-19 and to explore ... Lv Z, Lv S. Clinical characteristics and analysis of risk factors for disease progression of COVID-19: A retrospective Cohort ... Then we performed univariate and multivariate Cox regression analysis to identify potential risk factors for progression from ...
From analysis on the group with negative margins, the five-year progression-free survival rate was 74%. The primary tumor site ... This was a retrospective cohort study on 42 patients with chordoma who were treated at Hospital A. C. Camargo between 1980 and ... This was a retrospective cohort study on all 42 consecutive patients with chordoma who were treated in the A. C. Camargo Cancer ... This study has some limitations because it was conducted retrospectively, but it will certainly help other researchers and ...
The clinical progression pattern suggests that early control of viral replication and application of host-directed therapy in ... We investigated the temporal progression in patients with COVID-19. Methods: In this retrospective, single-center study, we ... Clinical progression of patients with COVID-19 in Shanghai, China J Infect. 2020 May;80(5):e1-e6. doi: 10.1016/j.jinf.2020.03. ... Background: Studies on the 2019 novel coronavirus disease (COVID-19) have generally been limited to the description of the ...
Design: Retrospective cohort study.. Participants and setting: Two cohorts of people with HIV were defined retrospectively from ... In this study, progression to AIDS was nearly halved and deaths fell by 80% among people with HIV infection whose CD4 cell ... This study contributes evidence to suggest that the rate of progression of HIV disease has decreased in Australia at the same ... The results of this study concur with recent cohort studies overseas, where substantial decreases in AIDS and deaths have been ...
In this retrospective study, the authors evaluated the benefit of alemtuzumab monotherapy in unselected patients with advanced ... A Nation-Wide Retrospective Study in Austria Cancer. 2006 Nov 15;107(10):2408-16. doi: 10.1002/cncr.22263. ... Background: In previous studies, alemtuzumab demonstrated considerable activity in patients with previously treated B-cell ... Austrian Collaborative Study Group on Alemtuzumab in Chronic Lymphocytic Leukemia ...
... a retrospective study Progression of solitary and multifocal papillary thyroid carcinoma - a retrospective study of 368 ... This study aimed to evaluate progression in patients with multifocal and solitary PTC.,/p,,p,,b,METHODS,/b,We performed a ... Retrospective Studies / Adult Language: English Journal: Chinese Medical Journal Year: 2012 Type: Article ... Retrospective Studies / Adult Language: English Journal: Chinese Medical Journal Year: 2012 Type: Article ...
Retrospective Studies Country/Region as subject: Asia Language: English Journal: Yonsei Medical Journal Year: 2016 Type: ... Retrospective Studies Country/Region as subject: Asia Language: English Journal: Yonsei Medical Journal Year: 2016 Type: ... Prognostic Factors for Recurrence and Progression in Korean Non-Muscle-Invasive Bladder Cancer Patients: A Retrospective, Multi ... progression-free survival (PFS; HR 1.56; p=0.037). In particular, on multivariable analysis conducted for the high-risk group ( ...
... biochemical and pharmacological prognostic factors for prostate cancer progression using primary care data. Samuel W D Merriel ... Merriel, S. W. D., Ingle, S. M., May, M. T., & Martin, R. M. (2020). Retrospective cohort study evaluating clinical, ... Merriel, SWD, Ingle, SM, May, MT & Martin, RM 2020, Retrospective cohort study evaluating clinical, biochemical and ... T1 - Retrospective cohort study evaluating clinical, biochemical and pharmacological prognostic factors for prostate cancer ...
Study Design and Data Source. The study design was a retrospective cohort study. We used data from Japans Ministry of Health, ... Study Limitations. Our study has several limitations. First, because the present study was based on an observational design, ... Further studies are needed to assess this.. In our risk factor analysis, age and dementia were risk factors for the progression ... In the present study, we compared the progression of care needs levels of long-term care recipients with advanced care ...
In this study, we aimed to identify risk factors for a higher susceptibility to symptomatic presentation with COVID-19 and a ... we used univariable and multivariable logistic regression to identify risk factors associated with progression to severe ... Risk factors for clinical progression in patients with COVID-19: a retrospective study of electronic health record data in the ... Risk factors for clinical progression in patients with COVID-19: a retrospective study of electronic health record data in the ...
This study investigated clinical outcome and post-progression management in a large cohort of French patients with ALK+ NSCLC ... A multicentric observational retrospective study to evaluate crizotinib outcome and post progression management in ALK positive ... A multicentric observational retrospective study to evaluate crizotinib outcome and post progression management in ALK positive ...
  • Methods Retrospective electronic case notes of patients who had diagnosis of AS with at least two echocardiogram between 2005 and 2009 were studied. (
  • METHODS: A retrospective case-control study set at the referral center for gynecologic endoscopy at Stanford University. (
  • METHODS: Sixty-two newly diagnosed CML patients (56 in chronic phase, 1 in accelerated phase, and 5 in blastic crises) were enrolled in the study. (
  • Methods This retrospective cohort study included 4731 adult men and women with no history of cardiovascular disease (CVD), liver disease or cancer at baseline who participated in a repeated regular health screening examination between 2004 and 2013. (
  • METHODS: In this study, 28 patients underwent at least 2 black-blood in vivo cardiovascular magnetic resonance (CMR) scans of aorta and carotids over a one-year period (Mean 17.8 +/- 7.5 months). (
  • Disclosures The authors report no conflict of interest concerning the materials or methods used in this study or the findings specified in this paper. (
  • Inexpensive markers of progression derived from easily obtained parameters, such as blood test or nutritional assessment, can be useful for the follow-up of HIV-infected children living in regions where the access to more sophisticated laboratory methods is not available before the infection progression is clinically detectable. (
  • METHODS: We performed a systematic review and meta-analysis of studies identified in PubMed and EMBASE that reported the proportion of patients treated with RFA who had complete eradication of dysplasia (CE-D) and intestinal metaplasia (CE-IM), and the proportion of patients with recurrent IM after successful treatment. (
  • Methods: This was a retrospective chart review study. (
  • Collaborative Longitudinal Evaluation of Keratoconus (CLEK) Study: methods and findings to date. (
  • From 2 to 5 years of retrospective fundus autofluorescence imaging linked with 2 years of standardized prospective fundus autofluorescence imaging will be collected. (
  • In this study, by facilitating a comprehensive coverage of patient characteristics, we aimed to clarify factors associated with prognosis of RN. (
  • The clinical progression pattern suggests that early control of viral replication and application of host-directed therapy in later stage is essential to improve the prognosis of CVOID-19. (
  • In the current study we aimed to investigate whether aggresomes-positivity could be used to improve the disease subclassification and prognosis prediction of pediatric medulloblastoma. (
  • No pharmacological therapy has delayed progression or improved prognosis. (
  • We investigated the temporal progression in patients with COVID-19. (
  • A retrospective cohort study was conducted to summarize the clinical characteristics of patients with COVID-19 and to explore the risk factors affecting the disease duration in Jiangan Fangcang shelter hospital, Wuhan, China. (
  • For patients with COVID-19, we used univariable and multivariable logistic regression to identify risk factors associated with progression to severe disease defined by: 1) admission to the hospital AICU, 2) the need for mechanical ventilation, 3) in-hospital mortality, and 4) at least one measurement of elevated D-dimer (equal or superior to 1,000 ug/L) indicative of increased risk of venous thromboembolism. (
  • When the COVID-19 pandemic started, Savana was able to start its Big COVIData study as soon as the first disease outbreak ravaged Europe, which defined the clinical characteristics and predictive factors for patients with COVID-19. (
  • The usage of atropine allowed to limit myopia progression but less AL. (
  • Inclusion criteria: -(11-14) years old -SER between -1.25 and - 4.50 D -Myopia progression ≥ 0.50D in the previous 12 months -Best corrected spectacle visual acuity of Snellen 6/6 or better -Prepared to wear contact lenses for at least 8 hours/day. (
  • Myopia progression and eye elongation were reduced significantly in eyes wearing Dual-Focus soft contact lenses. (
  • In 70% of the children, myopia progression was reduced by 30% or more in the eye wearing the Dual-Focus (DF) lens relative to that wearing the Single Vision Distance (SVD) lens. (
  • The daily wearing of DISC lens significantly slowed myopia progression and axial elongation in Hong Kong schoolchildren. (
  • Orthokeratology is effective in reducing myopia progression especially in children aged 6 to 8 years. (
  • A randomized trial of the effects of rigid contact lenses on myopia progression. (
  • To assess the yearly rate of progression of STGD using the growth of atrophic lesions as measured by fundus autofluorescence (FAF) imaging. (
  • Previous studies evaluating natural history of progression of AS shown that on average the rate of progression of Peak velocity across aortic valve is 0.24 m/s/year (m/s/yr). (
  • Orthokeratology (OK) lenses can reduce the rate of progression of childhood myopia over the long term. (
  • This study looks at the rate of progression to surgery and the characteristics associated with progression. (
  • AIMS While the role of bacteria in the initiation of periodontitis is primary, a range of host-related factors influence the onset, clinical presentation and rate of progression of disease. (
  • To be eligible for the study, both clinical and radiographic outcomes at 24 months had to be available. (
  • To study visual and refractive outcomes of simultaneous Intra corneal ring segments (ICRS) with corneal collagen crosslinking (CXL) in corneal ectasia and to define criteria for predictable outcome. (
  • Trials and observational studies did show that iron supplementation improved some maternal hematologic indices, but these studies provided inconclusive evidence that routine prenatal supplementation improved maternal or infant clinical outcomes. (
  • Planned projects include evaluation of testosterone levels in relationship to fertility treatments, prospective study on pregnancy outcomes of women with PCOS compared to other women undergoing fertility treatments, miscarriage rates with different diagnoses and treatments. (
  • The aim of this study was to evaluate treatment patterns and outcomes among CRPC patients with bone metastasis treated with radium-223 in clinical practice. (
  • Parathyroid hormone predicts both disease progression and associated adverse outcomes in untreated patients. (
  • Study outcomes were time to death or initiation of ART (excluding short-course for prevention of PMTCT). (
  • The investigators explored the association between these outcomes and hormonal contraception, pregnancy and breastfeeding, controlling for other factors known to be associated with HIV disease progression. (
  • Do statins improve outcomes and delay the progression of non-rheumatic calcific aortic stenosis? (
  • Context It is not known whether statin treatment improves clinical outcomes and reduces aortic stenosis progression in non-rheumatic calcific aortic stenosis. (
  • Objective A meta-analysis of studies was performed comparing statin therapy with placebo or no treatment on outcomes and on aortic stenosis progression echocardiographic parameters. (
  • Conclusions Currently available data do not support the use of statins to improve outcomes and to reduce disease progression in non-rheumatic calcific aortic valve stenosis. (
  • The quality of the evidence quality ranged from moderate to very low across the different outcomes due to the limitations of the original studies. (
  • CONCLUSIONS The findings from this study underscore the importance of population-level approaches to the prevention and treatment of obesity across the life course of individuals. (
  • CONCLUSIONS: No significant difference was found in the two groups, suggesting that IVF treatment does not lead to an accelerated progression of endometriosis in patients with recurrence. (
  • Conclusions In this large cohort study of adult men and women with no history of CVD, NAFLD was significantly associated with the development of CAC independent of cardiovascular and metabolic risk factors. (
  • CONCLUSIONS: Results of this study of multiple vascular beds indicated that different vascular locations exhibited varying progression of atherosclerosis and remodeling as monitored by CMR. (
  • CONCLUSIONS: Our study found some differences concerning the risk of evolution to clinically definite MS after a first demyelinating episode suggestive of ADEM. (
  • Conclusions: Based on the study findings, this thesis concludes that although PHPT has become a mild stable condition, the increased risk associated with untreated PHPT should not be neglected and requires vigorous management to avoid a future heath burden. (
  • The multi-center ProgStar studies aim to characterize the natural history of Stargardt disease in order to develop new outcome measures to test efficacy of forthcoming therapy trials. (
  • Visual acuity measures showed only a small yearly decline (an overall estimated decline of 1/3 line per year) and are not suitable as primary outcome measures in clinical trials for Stargardt disease that aim to slow down disease progression. (
  • BACKGROUND: The aim of this study was to examine the surgical findings at repeated surgeries for endometriosis and to compare disease progression in patients after IVF to those without interval fertility treatments. (
  • Does HOXA9 Gene Expression in Egyptian Chronic Myelogenous Leukemia Patients Affect Disease Progression? (
  • The clinical manifestation of mental disorder in Huntington's disease: a retrospective case record study of disease progression. (
  • Background and aim Non-alcoholic fatty liver disease (NAFLD), a hepatic manifestation of the metabolic syndrome, was associated with subclinical atherosclerosis in many cross-sectional studies, but the prospective association between NAFLD and the progression of atherosclerosis has not been evaluated. (
  • NAFLD may play a pathophysiological role in atherosclerosis development and may be useful to identify subjects with a higher risk of subclinical disease progression. (
  • BMI in the overweight range is associated with reduced risks of kidney disease progression and all-cause mortality in stage 3-4 CKD. (
  • Studies on the 2019 novel coronavirus disease (COVID-19) have generally been limited to the description of the epidemiology and initial clinical characteristics. (
  • To further evaluate disease progression, the pattern of progression and survival in hormonally treated metastatic prostate cancer was examined. (
  • One hundred and eighteen of the 193 patients (61.1%) had disease progression: 33 had local progression, 73 had distant progression and 12 had distant with local progression. (
  • Patients with only local progression had a longer interval to disease progression and longer survival than those with distant progression. (
  • The interval from disease progression to death in patients with local progression was longer than in those with distant progression. (
  • Lv Z, Lv S. Clinical characteristics and analysis of risk factors for disease progression of COVID-19: A retrospective Cohort Study. (
  • The univariate Cox regression analysis showed that old age, number of symptoms, the combination of hypertension, heart disease and pulmonary disease were associated with the progression of disease. (
  • The age of the patient, the combination of hypertension and heart disease were independent risk factors for the progression of COVID-19. (
  • To examine the effect of recent developments in antiretroviral therapy on HIV disease progression and survival. (
  • In clinical trials, these drugs have demonstrated significant ability to reduce disease progression and improve survival when added to existing regimens of antiretroviral treatments. (
  • The number of tumor foci did not affect progression of disease in multifocal PTC patients . (
  • In this study, we aimed to identify risk factors for a higher susceptibility to symptomatic presentation with COVID-19 and a transition to severe disease. (
  • Our main endpoints included overall survival (OS), progression-free survival (PFS), objective response rate (ORR), disease control rate (DCR), and AEs. (
  • Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis. (
  • Jantchou P, Morois S, Clavel-Chapelon F, Boutron-Ruault MC, Carbonnel F. Animal protein intake and risk of inflammatory bowel disease: The E3N prospective study. (
  • Association of NOD2 (CARD 15) genotype with clinical course of Crohn's disease: a cohort study. (
  • A genome-wide association study identifies IL23R as an inflammatory bowel disease gene. (
  • Complement Activation in Progression of Chronic Kidney Disease. (
  • The mechanisms underlying the progression to end-stage renal disease (ESRD) is not fully understood. (
  • Age-Related Eye Disease Study Research Group (2005). (
  • Risk factors for the incidence of advanced age-related macular degeneration in the Age-Related Eye Disease Study (AREDS) AREDS report no. 19. (
  • Visual symptoms in PD may represent a spectrum from OvS to VM to VH, with progression of the latter associated with older age, duration of disease, presence of REM sleep behavior disorder, cognitive impairment, and decreased gray-matter volume. (
  • Acute fulminant demyelinating disease: a descriptive study of 60 patients. (
  • The aim of this study is to develop a functional nomogram that can be used by clinicians to estimate the risk of in-hospital mortality in patients hospitalized and treated for COVID-19 disease, and to compare the accuracy of model predictions with previous nomograms. (
  • This retrospective study enrolled 709 patients who were over 18 years old and received inpatient treatment for COVID-19 disease. (
  • One hundred and seventeen people originally randomised to 400 mg/day who received an increased dose of 800 mg/day imatinib after disease progression were assessed for response. (
  • People with disease progression on 400 mg/day imatinib, but who could tolerate a higher imatinib dose, received an increased dose of 600 mg/day. (
  • People in this study received an initial dose of 400 mg/day imatinib that was increased to 600 or 800 mg/day imatinib on disease progression. (
  • 4.1.5 Overall, 28.1% (EORTC-ISG-AGITG), 34.2% (S0033) and 58.9% (B2222) of people initially randomised to receive 400 mg/day imatinib had disease progression and received either 600 or 800 mg/day imatinib. (
  • 2008), 31.4% of people received sunitinib after disease progression on 400 mg/day imatinib. (
  • 4.1.6 The results for people treated with an increased dose of 600 mg/day imatinib after disease progression on 400 mg/day imatinib were reported in the B2222 trial and the retrospective cohort study. (
  • After disease progression, 11 out of 43 people (25.6%) who increased to 600 mg/day imatinib either had a partial response or had stable disease. (
  • The Assessment Group noted that some of the people who received increased doses may have had an initial response to 400 mg/day imatinib before disease progression. (
  • Disease progression: identification of high-risk groups and individuals for periodontitis. (
  • article{HeitzMayfield2005DiseasePI, title={Disease progression: identification of high-risk groups and individuals for periodontitis. (
  • To analyze total lymphocyte count, total leukocyte count, hemoglobin levels, nutritional status, CD4+ T-lymphocyte count and viral load as markers of disease progression and/or death in HIV-infected children. (
  • The events of interest were: progression to clinical category C (according to the classification of the Centers for Disease Control and Prevention CDC, 1994) or death. (
  • In the multivariate analysis, only CD4+ T-lymphocytes count, according to the categories of the World Health Organization, and weight-for-age z score ≤ -2 were predictors of risk for disease progression in children older than 12 months. (
  • Nutritional status is an important aspect in the assessment of risk of disease progression in HIV-infected children older than 12 months. (
  • A meta-analysis of studies involving children evidenced that, for similar levels of plasma viral load and CD4+TL, the younger the child the higher the risk of disease progression or death. (
  • This helps users identify prognostic factors of disease progression, check the efficacy of pharmacological treatments and predict available health resources. (
  • At present, two international respiratory studies are being run, enabling high-quality collaborative research and cutting-edge investigation on chronic obstructive pulmonary disease and COVID-19 to improve the lives of people living with respiratory conditions. (
  • The researchers first conducted a retrospective review of data: they examined medical records of patients receiving treatment for both CHF and gastroesophageal reflux disease (GERD). (
  • There was disease progression despite therapy with mycophenolate and intravenous immunoglobulin. (
  • Increased serum levels of HIF-1α and IL-19 correlated with the disease progression of COPD, suggesting that they can be used as indicators to help us understand the COPD. (
  • We hypothesize that plasma IGF-I and serum IGFBP3 concentrations in breast cancer patients may provide useful information on the progression of their disease, and determine the probability of recurrence and survival. (
  • Due to the natural progression of their disease, these patients become more difficult to intubate as they get older. (
  • Do changes in CD4 density correlate with disease progression? (
  • Here, we examined the role of CD4 density for HIV disease progression by longitudinally quantifying CD4 densities on CD4+ T cells and monocytes of ART-naive HIV+ patients with different disease progression rates. (
  • Thus, postseroconversion CD4 counts define individual HIV disease progression rates that may help to identify patients who might benefit most from early ART. (
  • The study's authors found that the disease is often more advanced at diagnosis in children, with faster progression. (
  • This study aimed to explore the role of Lpa in the progression of atherosclerosis in patients with end-stage renal disease (ESRD) and to investigate whether its potential mechanism is mediated by CXC chemokine ligand 16 (CXCL16) and low-density lipoprotein receptor (LDLr). (
  • To study several traditional and less traditional risk factors for kidney disease progression in a cohort of patients with primary GN. (
  • Logistic and Cox regressions were used to associate DC-SCRIPT levels with clinical benefit and progression-free survival (PFS) for 296 patients treated with first-line systemic tamoxifen for advanced disease. (
  • However, whether HIV-induced oxidative stress is linked to faster liver disease progression in HIV/HCV-coinfected patients still lacks evidence. (
  • Despite this, there are conflicting data regarding the safety of hormonal contraceptives in terms of HIV disease progression. (
  • Evidence from clinical trials (DELTA and ACTG 175) 1,2 first defined the superiority of combination therapy over monotherapy in delaying progression to AIDS and prolonging survival. (
  • Although there has been anecdotal evidence in Australia suggesting that these treatments have reduced the overall number of AIDS cases and improved survival following AIDS, their effect has not been systematically studied. (
  • We therefore decided to compare the rates of progression to AIDS and survival in two cohorts of people between 1990-1993 and 1994-1997, with CD4+ T cell counts of 200 x 10 6 /L (CD4 cell count 200/µL) at entry to the study, as a basis for assessing the impact of new treatments. (
  • We compared survival without progression of care needs level between the groups, with and without advanced care management, using the Kaplan-Meier method. (
  • The average duration of progression-free survival was 17.4 (SD 10.2) months. (
  • The proportions of five-year cumulative progression-free survival were 41.2% and 32.8% in those with and without advanced care management, respectively. (
  • Kaplan-Meier survival curves for progression to surgical membrane peel were calculated. (
  • This study evaluated treatment patterns and overall survival (OS) among patients with mCRPC treated with radium-223 in an academic clinical setting. (
  • Response rate (RR) and progression free survival (PFS) and toxity were evaluated. (
  • We aimed to compare the outcome of long-term care recipients using facilities with advanced care management and conventional care management, in terms of care needs level progression. (
  • A multicentric observational retrospective study to evaluate crizotinib outcome and post progression management in ALK positive non small cell lung cancer. (
  • Genetics and outcome of atypical hemolytic-uremic syndrome in Turkish children: a retrospective study between 2010 and 2017, a single-center experience. (
  • The primary study outcome was treatment failure as defined by evidence of radiographic recurrence or progression and/or clinical or functional decline. (
  • The main outcome measure was progression to surgical intervention. (
  • None of the studies measured adverse events as a primary outcome. (
  • Outcome variables were curve progression and magnitude, surgical complications, and need for re-operation. (
  • Few epidemiological studies have investigated the long-term outcome of primary glomerulonephritis (GN) and its determinants in the decade since angiotensin-converting enzyme inhibitors entered widespread use. (
  • The purpose of this study is to compare the short term treatment outcome measures of the standard of care air cell stirrup brace to that of a high tide fracture boot in patients with later. (
  • Therefore, the objective of this study is to collect natural history data from a large population of children and adults in order to evaluate possible efficacy measures for planned clinical trials. (
  • The objective of this presentation is to estimate the yearly rate of visual acuity (VA) loss in participants of the ProgStar-1 study. (
  • OBJECTIVE - Because a pseudonormal pattern of ventricular filling has never been considered in studies that reported a prevalence of left ventricular diastolic dysfunction (LVDD) between 20 and 40%, our aim was to more completely evaluate the prevalence of LVDD in subjects with diabetes. (
  • The primary objective of this study was to confirm the relationship between DC-SCRIPT mRNA levels measured in primary breast cancers and tumor aggressiveness in a much larger, independent, breast cancer cohort. (
  • Retrospective, and Prospective Longitudinal Observational Study Incl. (
  • A retrospective observational study was done. (
  • A retrospective study was performed at the pathology department of a referral hospital in Muscat, Oman, over a 5-year period. (
  • Incidence of sarcoma histotypes and molecular subtypes in a prospective epidemiological study with central pathology review and molecular testing. (
  • In this study, we evaluated the association among DBP SNPs and AIDS progression in antiretroviral treatment (ART)-naïve-HIV-infected patients. (
  • This retrospective cohort study assessed antiretroviral naïve HIV-infected children who were asymptomatic or had mild and/or moderate symptoms. (
  • Progression into distant sites was a poor prognostic factor for patients with recurrence to endocrine therapy. (
  • To identify the prognostic factors related to tumor recurrence and progression in Korean patients with non- muscle -invasive bladder cancer (NMIBC). (
  • Using univariable and multivariable Cox proportional hazards models , the prognostic value of each variable was evaluated for the time to first recurrence and progression. (
  • With a median follow-up duration of 37 months, 866 patients (35.9%) experienced recurrence , and 137 (5.7%) experienced progression. (
  • Merriel, SWD , Ingle, SM , May, MT & Martin, RM 2020, ' Retrospective cohort study evaluating clinical, biochemical and pharmacological prognostic factors for prostate cancer progression using primary care data ', BMJ Open . (
  • The objectives of this review are (1) to present evidence for individual predictive factors associated with a patient's susceptibility to progression of periodontitis and (2) to describe the use of prognostic models aimed at identifying high-risk groups and individuals in a clinical setting. (
  • In this study we aimed to validate the prognostic value of DC-SCRIPT mRNA expression in a large independent breast cancer cohort. (
  • This study provides a higher level of evidence that DC-SCRIPT is indeed an independent, pure prognostic, factor for primary breast cancer and shows that DC-SCRIPT mRNA expression is most informative for either ESR1 -positive and/or ESR2 -low pT1 tumors. (
  • To provide a higher level of evidence for DC-SCRIPT mRNA expression as a prognostic marker, we now report on DC-SCRIPT expression and its significance in a retrospective validation study of 1,505 breast cancer patients with known ESR1 , ESR2 , and PGR expression levels. (
  • This study was conducted to evaluate the association between NAFLD and the progression of coronary atherosclerosis. (
  • The purpose of this study was to examine arterial remodeling and progression/regression of atherosclerosis in aorta and carotid arteries of individuals at risk for atherosclerosis normalized over a 1-year period. (
  • High plasma Lpa levels accelerated the progression of atherosclerosis in ESRD through inducing Lpa accumulation in the arteries, which was associated with LDLr and CXCL16. (
  • In the Atherosclerosis Risk in Communities Study, Virani et al. (
  • However, the potential mechanisms underlying Lpa-induced atherosclerosis progression remain unclear. (
  • Therefore, this study aimed to investigate the role of Lpa in the progression of atherosclerosis and to explore the association of Lpa deposition with LDLr and CXCL16 expression in radial arteries of ESRD patients. (
  • 1 As several studies have indicated that aortic stenosis progression is due to an active process sharing several features with atherosclerosis, several trials have assessed the role of statins in delaying such progression, but with conflicting results. (
  • Lower limb malalignment is a strong predictor of progression in knee osteoarthritis. (
  • In the progression of osteoarthritis (OA) of the knee, a correlation between meniscal posterior segment injuries and medial meniscal extrusion has been reported, but there have been few reports on the relationship with the meniscal shape. (
  • The purpose of this study is to identify the individual alignment variables that predict progression in early to moderate osteoarthritis of the knee. (
  • A longitudinal cohort study using data from the Osteoarthritis Initiative. (
  • With this in mind, a longitudinal cohort study was designed using data from the Osteoarthritis Initiative (OAI). (
  • Are patients more likely to have hip osteoarthritis progression and femoral head collapse after hip steroid/anesthetic injections? (
  • To evaluate progression of osteoarthritis and femoral head articular surface collapse in hip steroid/anesthetic injection patients (HIPs). (
  • Thirty-one (31 out of 70, 44%) of HIPs had progression of osteoarthritis after injection, versus 17 out of 70 (24%) of hip controls (HCs) and 13 out of 44 (30%) of glenohumeral injection patients (GIPs). (
  • Hip steroid/anesthetic injection patients are more likely to demonstrate osteoarthritis progression and femoral head collapse than HC and GIPs in the injected joint 3-12 months after steroid and anesthetic injection. (
  • Colchicine also has been studied for osteoarthritis of the knee, refractory constipation, and postpericardiotomy syndrome at similar doses. (
  • One set included 455 knees of subjects whose OA grade on the Kellgren Lawrence (KL) scale progressed in 24 months from baseline and the other set consisted of 455 knees with no progression. (
  • Our findings suggested (1) a larger meniscal LD at the baseline predicted progression of knee OA after 24 months and (2) a larger meniscal width and smaller meniscal angle predicted progression of knee OA after 24 months. (
  • Progression was identified when the increase of edema area ≥ 25% on the MRI taken in six months comparing with those taken at the baseline. (
  • A minority of patients with newly diagnosed ERMs who did not need surgical intervention progressed to needing surgery at 7 years with the rate and speed of progression dependent on baseline OCT morphology. (
  • The Adolescent and Child Health Initiative to Encourage Vision Empowerment (ACHIEVE) study design and baseline data. (
  • Retrospective radiographic and medical chart review with matched control group. (
  • These results represent also 50% vs known natural progressions. (
  • These results confim that myopia control strategies offer a global reduction of 50% of the natural progression. (
  • Study record managers: refer to the Data Element Definitions if submitting registration or results information. (
  • The aim of this study was analyze the long-term results from treating this pathological condition. (
  • Our results suggest that the risk of structural progression in the medial compartment is associated with greater varus alignment of the proximal tibia. (
  • RESULTS: We identified 18 studies of 3802 patients reporting efficacy and 6 studies of 540 patients reporting durability. (
  • Lead researcher Masafumi Kitakaze, MD, PhD, director of the Cardiovascular Division and vice president of the Research and Clinical Center at the National Cardiovascular Center, and colleagues published their study results in the October 3rd edition of the Journal of the American College of Cardiology . (
  • Results: The prevalence of PHPT is increasing annually during the study period with an unexpected cyclic incidence. (
  • Results: The 14 patients with lung adenocarcinoma were reviewed in this retrospective study. (
  • Subjects with documented progression of keratoconus were included in study. (
  • This retrospective study compared keratoconus severity at diagnosis and scalability during a two-year period in children versus adults. (
  • Dr. Zadnik was the Study Chairman for the NEI-funded Collaborative Longitudinal Evaluation of Ethnicity and Refractive Error (CLEERE) Study and chaired the first-ever NEI-funded multicenter study based in optometry, the Collaborative Longitudinal Evaluation of Keratoconus (CLEK) Study from 1994 through 2007. (
  • Variables affecting rigid contact lens comfort in the collaborative longitudinal evaluation of keratoconus (CLEK) study. (
  • Participants will be recruited from each Investigator's own patient population as the study requires the availability of both multiyear retrospective data, as well as ongoing prospectively collected data. (
  • The study population comprised participants from the OAI. (
  • Data and samples acquired from study participants are available to the scientific community to conduct research. (
  • 30 Participants data will be collected during the study. (
  • Study Participants. (
  • Purpose Progression of Aortic Stenosis (AS) has been subject of much debate in the recent past with studies evaluating effects of statin therapy. (
  • 2 3 Since 2001, several studies, mainly observational, suggested that statin therapy delays the progression of calcific non-rheumatic aortic stenosis, assessed by echocardiography or CT. (
  • This was supported by several early observational studies suggesting reduction in AS progression with statin therapy, independent of changes in plasma lipids. (
  • Numerous studies have attempted to determine the prevalence of LVDD in middle-aged asymptomatic subjects with type 2 diabetes ( 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 ). (
  • The objectives of this study were 1 ) to more clearly establish the prevalence of LVDD in normotensive subjects with well-controlled type 2 diabetes with Doppler echocardiography using pulmonary flow recordings and the Valsalva maneuver to unmask a pseudonormal pattern and 2 ) to evaluate more precisely the association between LVDD and indexes of metabolic control in individuals with type 2 diabetes. (
  • A small retrospective study showed that patients with PD and diabetes who took the antihyperglycemic agent performed significantly better on tests of motor and nonmotor function than their counterparts who did not. (
  • mean age, 65 years) with diabetes mellitus from the Parkinson's Progression Markers Initiative (PPMI) cohort. (
  • Socio-economic inequalities in diabetes complications, control, attitudes and health service use: a cross-sectional study. (
  • Lifestyle changes or metformin can delay the progression of prediabetes to overt diabetes. (
  • Ask your learners what interventions prevent progression to overt diabetes. (
  • The aim of our study was to characterize, collate, and analyze the evidence from evaluation of social prescribing for type 2 diabetes in the United Kingdom and Ireland, comparing information available on publicly available websites with the published literature. (
  • Our study revealed the varied models of social prescribing and nonmedical, community-based services available to people with type 2 diabetes and the extent of evaluation of these, which would not have been achieved by searching databases alone. (
  • The findings of this scoping study do not prove that social prescribing is an effective measure for people with type 2 diabetes in the United Kingdom, but can be used to inform future evaluation and contribute to the development of the evidence base for social prescribing. (
  • She continued, "While data gathered in our own research with Gartner - the 2017 Women in Supply Chain Study - still shows a significant gap between the numbers of men and women in senior leadership roles, there is a sense of momentum and higher expectations. (
  • To identify the effect of intrathecal baclofen on the incidence of scoliosis, rate of curve progression, and pelvic obliquity compared with a matched cohort. (
  • This study demonstrates that ITB has no significant effect on curve progression, pelvic obliquity, or the incidence of scoliosis when compared with an age, gender, and GMFCS score-matched control group of patients with spastic CP without ITB. (
  • 13 Studies show that increased IL-19 is involved in the incidence of autoimmune diseases 12 such as psoriasis, asthma, and rheumatoid arthritis by upregulating pro-inflammatory cytokines. (
  • We have undertaken a meta-analysis of studies of the effect of statins on the incidence of hard endpoints and on retarding stenosis progression. (
  • PDF] Neurologic deterioration secondary to unrecognized spinal instability following trauma--a multicenter study. (
  • A concurrent ancillary study (SMART study) is also being conducted with a subset of the prospective study patients during their regular ProgSTAR study visits to expand the collection of retinal images to include microperimetry measurements gathered under scotopic (low light) conditions. (
  • Switching from natalizumab to fingolimod in multiple sclerosis: a French prospective study. (
  • We performed the present prospective study with only 50 CHF patients," said Dr Kitakaze. (
  • Further evidences from large-scale prospective study and randomization trial are desired to confirm the effect of cilostazol. (
  • Investigators therefore designed a prospective study involving HIV-positive women recruited between 1994 and 2012. (
  • The purpose of this study was to determine (i) natural progression of complications associated with lymphatic malformations during childhood and adolescence , (ii) risk factors associated with complications, and (iii) whether early intervention decreases LM complication rates in adolescents or young adults. (
  • Then we performed univariate and multivariate Cox regression analysis to identify potential risk factors for progression from non-severe to severe COVID-19 or death. (
  • P = 0.034) were independent risk factors for progression of COVID-19. (
  • Risk factors for five-year incident age-related macular degeneration: the Reykjavik Eye Study. (
  • In addition, some of the risk factors found in previous studies (such as IL-6, Glasgow Coma Scale and viral load) are not controlled for every patient in their daily routine. (
  • Previous studies have documented that risk factors predisposing to acanthamoeba keratitis in contact lens wearers include non-sterile contact lens solutions, swimming in contact lenses, and inadequate disinfection. (
  • Since the Leventhal and Cleary paper, a number of investigators have completed longitudinal studies focusing on demographic predictors of smoking, 2 on risk factors to predict smoking, 3 or on grouping smokers according to their patterns of use over time. (
  • [ 3 ] The reported interval from DLE diagnosis to SLE onset has varied widely, with a mean time to progression of approximately 8 years in one study, with another small cohort study reporting the median time to progression from DLE to SLE of 453 days. (
  • There were 13 patients with glucose 126 mg/dl, time to progression was 23 months (range 8-48). (
  • Conclusion Our study has shown that Osteoporotic patients on Bisphosphonate have significantly decreased progression of AS. (
  • Only the Medial Proximal Tibial Angle was significantly associated with structural progression and none of the variables was associated with symptom progression. (
  • The progression of visual field defects was defined by a significantly negative value of the mean deviation slope at the final visual field test during the follow-up period. (
  • Statins did not significantly affect the progression over time of peak and mean aortic gradient. (
  • Lower-quality (retrospective or non-randomised) studies showed that, in statin-treated patients, the annual increase in peak aortic jet velocity and the annual decrease in aortic valve area were lower, but this was not confirmed by the analysis in high-quality (prospective or randomised) studies. (
  • A parent of a 9 year old male suffering from myopia came to the clinic wondering if using contact lenses would slow the progression of myopia in her child as she read in the Internet. (
  • Dr Kitakaze and colleagues speculated that blocking the effects of a histamine released by damaged heart cells might slow the progression of heart failure. (
  • To correlate the presence and progression of morphological abnormalities in FAF and sd-OCT images with visual function as measured by microperimetry and visual acuity. (
  • Vitamin D receptor polymorphism (-1056 Taq-I) interacts with smoking for the presence and progression of periodontitis. (
  • Surgery is the mainstay of treatment and local control is better achieved with en bloc resection of the tumor with safe margins. (
  • All patients who had undergone STR or biopsy required repeat resection for tumor control or progression. (
  • We are now beginning to understand the genetic mechanisms of thyroid tumor initiation and progression. (
  • To perform exploratory analysis of factors associated with STGD progression, such as participant's use of vitamin A supplementation, and mutations in the ABCA4 gene. (
  • Little is known about the factors that affect progression of AS. (
  • Among local factors, the role of the menisci in maintaining the local physiological mechanical environment is well established and their failure to fulfill this role leads to knee OA development or its progression. (
  • The relationships between the progression of visual field defects and IOP, as well as other clinical factors, were retrospectively analyzed. (
  • That progression is due mainly to three factors. (
  • 3 Simultaneously, factors that may alter the progression of valve calcification and dysfunction, such as hypertension and lipid metabolism, have been increasingly elucidated. (
  • We performed a retrospective analysis of the RN patients (The patients included in our study had a history of primary cancers including nasopharyngeal carcinoma/glioma/oral cancer and received radiotherapy previously and then were diagnosed with RN) treated in Sun yat-sen Memorial Hospital from January 2013 to August 2015. (
  • We performed this study to assess the feasibility and efficacy of using IMRT with reduced-volume CTV for the treatment of nasopharyngeal carcinoma. (
  • The purpose of this study was to evaluate whether IFN therapy for chronic hepatitis C could overcome telomere reduction in the liver, a possible risk factor for hepatocellular carcinoma (HCC) development. (
  • For patients suffering from metastatic or extensive carcinoma with impaired liver function, several drug regimes maintain quality of life and decelerate progression. (
  • DESIGN: Observational, retrospective case study. (
  • STUDY DESIGN A retrospective study was undertaken that evaluated the medical records and imaging studies of a subset of patients with spinal injury from large level I trauma centers. (
  • Design: A large retrospective cohort study using routinely collected data in Tayside, Scotland, 1997-2006. (
  • Data extraction Two independent reviewers independently abstracted information on study design (prospective vs retrospective or randomised vs non-randomised), study and participant characteristics. (
  • VEN in combination with rituximab (R) is being assessed in an ongoing Phase 1b study. (
  • BACKGROUND: Recent studies suggest that there is a learning curve for metal-on-metal hip resurfacing. (
  • This study aimed to evaluate progression in patients with multifocal and solitary PTC. (
  • In the retrospective cohort study the median length of follow-up was 8 months (range 1.4-22.3 months). (
  • This cohort study enrolled 217 HD patients (median follow-up time: 5.75 years). (
  • Twenty-five age, gender, and gross motor function classification system (GMFCS) score-matched quadriplegic CP patients with scoliosis who did not receive ITB constituted the control group used to compare the rate of curve progression and pelvic obliquity. (
  • Both groups' curves progressed over time during growth (P = 0.001), but baclofen did not have an independent effect on curve progression (P = 0.181). (
  • No patient required definitive fusion for curve progression. (
  • Clinical, epidemiological, and pathological studies attribute the increased occurrence of clinical congestive heart failure in diabetic subjects to diabetic cardiomyopathy, which could take the form of diastolic and/or systolic left ventricular dysfunction ( 2 , 3 ). (
  • Our study suggested that multifocal PTC was more related to lymph node metastasis and vascular invasion than solitary PTC. (
  • The benefit of a number of antiplatelet medications, including aspirin and clopidogrel, has been demonstrated in a wide set of studies of symptomatic individuals for whom a decreased risk of heart attack, stroke, and vascular death has been confirmed [ 9 ]. (
  • 8 Studies have shown that HIF-1α and its downstream vascular endothelial growth factor genes may be associated with COPD. (
  • Two cohorts of subjects in this study with CD4 cell counts of 200/µL were defined retrospectively from records of routine CD4 cell counts undertaken at the Centre for Immunology, St Vincent's Hospital, Sydney. (
  • Subjects included were HIV-positive but without AIDS at entry to the study, with CD4 cell counts declining through 200/µL in the index year (1990 or 1994) or with a single CD4 cell count in the range 180-220/µL. (
  • We performed a retrospective study in 667 patients who were classified according to their pattern of AIDS progression (183 long-term non-progressors (LTNPs), 334 moderate progressors (MPs), and 150 rapid progressors (RPs)) and 113 healthy blood donors (HIV, HCV, and HBV negative subjects). (
  • The subjects of the study were patients undergoing treatment for POAG or NTG who had performed visual field tests at least ten times with a Humphrey field analyzer (Swedish interactive thresholding algorithm standard, C30-2 program). (
  • 1 Observational studies suggest that a relatively high proportion of asymptomatic subjects manifest hemodynamically apparent VHDs varying from mild to severe. (
  • Nevertheless, clinical studies provide weak evidence of the efficacy of antiplatelet agents in preventing PAD progression [ 10 , 11 ]. (
  • A systematic review to assess the efficacy of GC in inhibiting radiological progression in adults with RA 1 showed that the patients treated with constant low-dose GC had substantially less joint damage at radiological followup at 1 and 2 years. (
  • We performed this study to investigate the feasibility and efficacy of using IMRT with reduced-volume CTV for the treatment of NPC, with the hope to provide certain reference meanings for further studies. (
  • This study found no relevant trials of screening for iron deficiency anemia in asymptomatic, nonanemic pregnant women living in developed countries. (
  • There were 3 prospective, randomized clinical trials, 7 nonrandomized prospective comparative studies and 3 retrospective case series. (
  • 4.1.2 The Assessment Group did not identify any randomised controlled trials or non-randomised studies comparing the effectiveness of increased doses of imatinib (600 or 800 mg/day) with sunitinib or best supportive care. (
  • A clear understanding of the predictors that cause structural progression, symptom worsening or non-progression more likely in individuals with symptomatic early to moderate knee OA is necessary. (