A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.
A class of statistical procedures for estimating the survival function (function of time, starting with a population 100% well at a given time and providing the percentage of the population still well at later times). The survival analysis is then used for making inferences about the effects of treatments, prognostic factors, exposures, and other covariates on the function.
Molecular products metabolized and secreted by neoplastic tissue and characterized biochemically in cells or body fluids. They are indicators of tumor stage and grade as well as useful for monitoring responses to treatment and predicting recurrence. Many chemical groups are represented including hormones, antigens, amino and nucleic acids, enzymes, polyamines, and specific cell membrane proteins and lipids.
The proportion of survivors in a group, e.g., of patients, studied and followed over a period, or the proportion of persons in a specified group alive at the beginning of a time interval who survive to the end of the interval. It is often studied using life table methods.
Methods which attempt to express in replicable terms the extent of the neoplasm in the patient.
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.
A nonparametric method of compiling LIFE TABLES or survival tables. It combines calculated probabilities of survival and estimates to allow for observations occurring beyond a measurement threshold, which are assumed to occur randomly. Time intervals are defined as ending each time an event occurs and are therefore unequal. (From Last, A Dictionary of Epidemiology, 1995)
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
Histochemical localization of immunoreactive substances using labeled antibodies as reagents.
Tumors or cancer of the human BREAST.
Period after successful treatment in which there is no appearance of the symptoms or effects of the disease.
A set of techniques used when variation in several variables has to be studied simultaneously. In statistics, multivariate analysis is interpreted as any analytic method that allows simultaneous study of two or more dependent variables.
Transfer of a neoplasm from its primary site to lymph nodes or to distant parts of the body by way of the lymphatic system.
Statistical models used in survival analysis that assert that the effect of the study factors on the hazard rate in the study population is multiplicative and does not change over time.
In screening and diagnostic tests, the probability that a person with a positive test is a true positive (i.e., has the disease), is referred to as the predictive value of a positive test; whereas, the predictive value of a negative test is the probability that the person with a negative test does not have the disease. Predictive value is related to the sensitivity and specificity of the test.
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action in neoplastic tissue.
Elements of limited time intervals, contributing to particular results or situations.
A malignant epithelial tumor with a glandular organization.
The worsening of a disease over time. This concept is most often used for chronic and incurable diseases where the stage of the disease is an important determinant of therapy and prognosis.
Ability of neoplasms to infiltrate and actively destroy surrounding tissue.
An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.
Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.
The local recurrence of a neoplasm following treatment. It arises from microscopic cells of the original neoplasm that have escaped therapeutic intervention and later become clinically visible at the original site.
Tumors or cancer of the LUNG.
A carcinoma derived from stratified SQUAMOUS EPITHELIAL CELLS. It may also occur in sites where glandular or columnar epithelium is normally present. (From Stedman, 25th ed)
A cell line derived from cultured tumor cells.
Tumors or cancer of the LIVER.
The transfer of a neoplasm from one organ or part of the body to another remote from the primary site.
Tumors or cancer of the STOMACH.
Studies in which subsets of a defined population are identified. These groups may or may not be exposed to factors hypothesized to influence the probability of the occurrence of a particular disease or other outcome. Cohorts are defined populations which, as a whole, are followed in an attempt to determine distinguishing subgroup characteristics.
The treatment of a disease or condition by several different means simultaneously or sequentially. Chemoimmunotherapy, RADIOIMMUNOTHERAPY, chemoradiotherapy, cryochemotherapy, and SALVAGE THERAPY are seen most frequently, but their combinations with each other and surgery are also used.
The simultaneous analysis of multiple samples of TISSUES or CELLS from BIOPSY or in vitro culture that have been arranged in an array format on slides or microchips.
A malignant neoplasm made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases. It is a histological type of neoplasm but is often wrongly used as a synonym for "cancer." (From Dorland, 27th ed)
The determination of the pattern of genes expressed at the level of GENETIC TRANSCRIPTION, under specific circumstances or in a specific cell.
The return of a sign, symptom, or disease after a remission.
A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.
Methods which attempt to express in replicable terms the level of CELL DIFFERENTIATION in neoplasms as increasing ANAPLASIA correlates with the aggressiveness of the neoplasm.
Neoplasms of the intracranial components of the central nervous system, including the cerebral hemispheres, basal ganglia, hypothalamus, thalamus, brain stem, and cerebellum. Brain neoplasms are subdivided into primary (originating from brain tissue) and secondary (i.e., metastatic) forms. Primary neoplasms are subdivided into benign and malignant forms. In general, brain tumors may also be classified by age of onset, histologic type, or presenting location in the brain.
Age as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or the effect of a circumstance. It is used with human or animal concepts but should be differentiated from AGING, a physiological process, and TIME FACTORS which refers only to the passage of time.
Tumors or cancer of the COLON or the RECTUM or both. Risk factors for colorectal cancer include chronic ULCERATIVE COLITIS; FAMILIAL POLYPOSIS COLI; exposure to ASBESTOS; and irradiation of the CERVIX UTERI.
The use of two or more chemicals simultaneously or sequentially in the drug therapy of neoplasms. The drugs need not be in the same dosage form.
Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.
Proteins whose abnormal expression (gain or loss) are associated with the development, growth, or progression of NEOPLASMS. Some neoplasm proteins are tumor antigens (ANTIGENS, NEOPLASM), i.e. they induce an immune reaction to their tumor. Many neoplasm proteins have been characterized and are used as tumor markers (BIOMARKERS, TUMOR) when they are detectable in cells and body fluids as monitors for the presence or growth of tumors. Abnormal expression of ONCOGENE PROTEINS is involved in neoplastic transformation, whereas the loss of expression of TUMOR SUPPRESSOR PROTEINS is involved with the loss of growth control and progression of the neoplasm.
Tumors or cancer of the ESOPHAGUS.
A cell surface protein-tyrosine kinase receptor that is overexpressed in a variety of ADENOCARCINOMAS. It has extensive homology to and heterodimerizes with the EGF RECEPTOR, the ERBB-3 RECEPTOR, and the ERBB-4 RECEPTOR. Activation of the erbB-2 receptor occurs through heterodimer formation with a ligand-bound erbB receptor family member.
Immunologic techniques based on the use of: (1) enzyme-antibody conjugates; (2) enzyme-antigen conjugates; (3) antienzyme antibody followed by its homologous enzyme; or (4) enzyme-antienzyme complexes. These are used histologically for visualizing or labeling tissue specimens.
Tomography using x-ray transmission and a computer algorithm to reconstruct the image.
The qualitative or quantitative estimation of the likelihood of adverse effects that may result from exposure to specified health hazards or from the absence of beneficial influences. (Last, Dictionary of Epidemiology, 1988)
Levels within a diagnostic group which are established by various measurement criteria applied to the seriousness of a patient's disorder.
Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).
Substances that inhibit or prevent the proliferation of NEOPLASMS.
A variation of the PCR technique in which cDNA is made from RNA via reverse transcription. The resultant cDNA is then amplified using standard PCR protocols.
A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)
Disease having a short and relatively severe course.
A CELL CYCLE and tumor growth marker which can be readily detected using IMMUNOCYTOCHEMISTRY methods. Ki-67 is a nuclear antigen present only in the nuclei of cycling cells.
A heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic need of the body. Heart failure can be caused by structural defects, functional abnormalities (VENTRICULAR DYSFUNCTION), or a sudden overload beyond its capacity. Chronic heart failure is more common than acute heart failure which results from sudden insult to cardiac function, such as MYOCARDIAL INFARCTION.
Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS.
Cytoplasmic proteins that bind estrogens and migrate to the nucleus where they regulate DNA transcription. Evaluation of the state of estrogen receptors in breast cancer patients has become clinically important.
An adenocarcinoma producing mucin in significant amounts. (From Dorland, 27th ed)
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.
A heterogeneous aggregate of at least three distinct histological types of lung cancer, including SQUAMOUS CELL CARCINOMA; ADENOCARCINOMA; and LARGE CELL CARCINOMA. They are dealt with collectively because of their shared treatment strategy.
Nuclear phosphoprotein encoded by the p53 gene (GENES, P53) whose normal function is to control CELL PROLIFERATION and APOPTOSIS. A mutant or absent p53 protein has been found in LEUKEMIA; OSTEOSARCOMA; LUNG CANCER; and COLORECTAL CANCER.
NECROSIS of the MYOCARDIUM caused by an obstruction of the blood supply to the heart (CORONARY CIRCULATION).
DNA present in neoplastic tissue.
Tumors or cancer of the SKIN.
Death resulting from the presence of a disease in an individual, as shown by a single case report or a limited number of patients. This should be differentiated from DEATH, the physiological cessation of life and from MORTALITY, an epidemiological or statistical concept.
Tumors or cancers of the KIDNEY.
A distribution in which a variable is distributed like the sum of the squares of any given independent random variable, each of which has a normal distribution with mean of zero and variance of one. The chi-square test is a statistical test based on comparison of a test statistic to a chi-square distribution. The oldest of these tests are used to detect whether two or more population distributions differ from one another.
Hybridization of a nucleic acid sample to a very large set of OLIGONUCLEOTIDE PROBES, which have been attached individually in columns and rows to a solid support, to determine a BASE SEQUENCE, or to detect variations in a gene sequence, GENE EXPRESSION, or for GENE MAPPING.
Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.
Removal and pathologic examination of specimens in the form of small pieces of tissue from the living body.
Drug therapy given to augment or stimulate some other form of treatment such as surgery or radiation therapy. Adjuvant chemotherapy is commonly used in the therapy of cancer and can be administered before or after the primary treatment.
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
Specific proteins found in or on cells of progesterone target tissues that specifically combine with progesterone. The cytosol progesterone-receptor complex then associates with the nucleic acids to initiate protein synthesis. There are two kinds of progesterone receptors, A and B. Both are induced by estrogen and have short half-lives.
The number of new cases of a given disease during a given period in a specified population. It also is used for the rate at which new events occur in a defined population. It is differentiated from PREVALENCE, which refers to all cases, new or old, in the population at a given time.
All of the processes involved in increasing CELL NUMBER including CELL DIVISION.
Studies which start with the identification of persons with a disease of interest and a control (comparison, referent) group without the disease. The relationship of an attribute to the disease is examined by comparing diseased and non-diseased persons with regard to the frequency or levels of the attribute in each group.
They are oval or bean shaped bodies (1 - 30 mm in diameter) located along the lymphatic system.
A malignant tumor arising from the epithelium of the BILE DUCTS.
Tumors or cancer of the BILE DUCTS.
An invasive (infiltrating) CARCINOMA of the mammary ductal system (MAMMARY GLANDS) in the human BREAST.
Abnormal number or structure of chromosomes. Chromosome aberrations may result in CHROMOSOME DISORDERS.
A graphic means for assessing the ability of a screening test to discriminate between healthy and diseased persons; may also be used in other studies, e.g., distinguishing stimuli responses as to a faint stimuli or nonstimuli.
A type of IN SITU HYBRIDIZATION in which target sequences are stained with fluorescent dye so their location and size can be determined using fluorescence microscopy. This staining is sufficiently distinct that the hybridization signal can be seen both in metaphase spreads and in interphase nuclei.
A malignant form of astrocytoma histologically characterized by pleomorphism of cells, nuclear atypia, microhemorrhage, and necrosis. They may arise in any region of the central nervous system, with a predilection for the cerebral hemispheres, basal ganglia, and commissural pathways. Clinical presentation most frequently occurs in the fifth or sixth decade of life with focal neurologic signs or seizures.
A common neoplasm of early childhood arising from neural crest cells in the sympathetic nervous system, and characterized by diverse clinical behavior, ranging from spontaneous remission to rapid metastatic progression and death. This tumor is the most common intraabdominal malignancy of childhood, but it may also arise from thorax, neck, or rarely occur in the central nervous system. Histologic features include uniform round cells with hyperchromatic nuclei arranged in nests and separated by fibrovascular septa. Neuroblastomas may be associated with the opsoclonus-myoclonus syndrome. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2099-2101; Curr Opin Oncol 1998 Jan;10(1):43-51)
Tumors or cancer located in bone tissue or specific BONES.
Malignant lymphoma composed of large B lymphoid cells whose nuclear size can exceed normal macrophage nuclei, or more than twice the size of a normal lymphocyte. The pattern is predominantly diffuse. Most of these lymphomas represent the malignant counterpart of B-lymphocytes at midstage in the process of differentiation.
Non-invasive method of demonstrating internal anatomy based on the principle that atomic nuclei in a strong magnetic field absorb pulses of radiofrequency energy and emit them as radiowaves which can be reconstructed into computerized images. The concept includes proton spin tomographic techniques.
A heterogeneous group of sporadic or hereditary carcinoma derived from cells of the KIDNEYS. There are several subtypes including the clear cells, the papillary, the chromophobe, the collecting duct, the spindle cells (sarcomatoid), or mixed cell-type carcinoma.
Tumors or cancer of the gallbladder.
The systems and processes involved in the establishment, support, management, and operation of registers, e.g., disease registers.
Addition of methyl groups to DNA. DNA methyltransferases (DNA methylases) perform this reaction using S-ADENOSYLMETHIONINE as the methyl group donor.
Therapeutic act or process that initiates a response to a complete or partial remission level.
A connective tissue neoplasm formed by proliferation of mesodermal cells; it is usually highly malignant.
An infant during the first month after birth.
In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.
Benign and malignant central nervous system neoplasms derived from glial cells (i.e., astrocytes, oligodendrocytes, and ependymocytes). Astrocytes may give rise to astrocytomas (ASTROCYTOMA) or glioblastoma multiforme (see GLIOBLASTOMA). Oligodendrocytes give rise to oligodendrogliomas (OLIGODENDROGLIOMA) and ependymocytes may undergo transformation to become EPENDYMOMA; CHOROID PLEXUS NEOPLASMS; or colloid cysts of the third ventricle. (From Escourolle et al., Manual of Basic Neuropathology, 2nd ed, p21)
The degree of replication of the chromosome set in the karyotype.
The statistical reproducibility of measurements (often in a clinical context), including the testing of instrumentation or techniques to obtain reproducible results. The concept includes reproducibility of physiological measurements, which may be used to develop rules to assess probability or prognosis, or response to a stimulus; reproducibility of occurrence of a condition; and reproducibility of experimental results.
An antitumor alkaloid isolated from VINCA ROSEA. (Merck, 11th ed.)
Clonal expansion of myeloid blasts in bone marrow, blood, and other tissue. Myeloid leukemias develop from changes in cells that normally produce NEUTROPHILS; BASOPHILS; EOSINOPHILS; and MONOCYTES.
A selective increase in the number of copies of a gene coding for a specific protein without a proportional increase in other genes. It occurs naturally via the excision of a copy of the repeating sequence from the chromosome and its extrachromosomal replication in a plasmid, or via the production of an RNA transcript of the entire repeating sequence of ribosomal RNA followed by the reverse transcription of the molecule to produce an additional copy of the original DNA sequence. Laboratory techniques have been introduced for inducing disproportional replication by unequal crossing over, uptake of DNA from lysed cells, or generation of extrachromosomal sequences from rolling circle replication.
Proteins, glycoprotein, or lipoprotein moieties on surfaces of tumor cells that are usually identified by monoclonal antibodies. Many of these are of either embryonic or viral origin.
Tumors or cancer of the MOUTH.
Soft tissue tumors or cancer arising from the mucosal surfaces of the LIP; oral cavity; PHARYNX; LARYNX; and cervical esophagus. Other sites included are the NOSE and PARANASAL SINUSES; SALIVARY GLANDS; THYROID GLAND and PARATHYROID GLANDS; and MELANOMA and non-melanoma skin cancers of the head and neck. (from Holland et al., Cancer Medicine, 4th ed, p1651)
Carcinoma that arises from the PANCREATIC DUCTS. It accounts for the majority of cancers derived from the PANCREAS.
Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the LIVER to form the active aldophosphamide. It has been used in the treatment of LYMPHOMA and LEUKEMIA. Its side effect, ALOPECIA, has been used for defleecing sheep. Cyclophosphamide may also cause sterility, birth defects, mutations, and cancer.
Passages within the liver for the conveyance of bile. Includes right and left hepatic ducts even though these may join outside the liver to form the common hepatic duct.
Maleness or femaleness as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or effect of a circumstance. It is used with human or animal concepts but should be differentiated from SEX CHARACTERISTICS, anatomical or physiological manifestations of sex, and from SEX DISTRIBUTION, the number of males and females in given circumstances.
A pathologic process consisting of the proliferation of blood vessels in abnormal tissues or in abnormal positions.
A neoplasm characterized by abnormalities of the lymphoid cell precursors leading to excessive lymphoblasts in the marrow and other organs. It is the most common cancer in children and accounts for the vast majority of all childhood leukemias.
The first alpha-globulins to appear in mammalian sera during FETAL DEVELOPMENT and the dominant serum proteins in early embryonic life.
One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.
An expression of the number of mitoses found in a stated number of cells.
Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care. (Dictionary of Health Services Management, 2d ed)
Resistance or diminished response of a neoplasm to an antineoplastic agent in humans, animals, or cell or tissue cultures.
Excision of the whole (total gastrectomy) or part (subtotal gastrectomy, partial gastrectomy, gastric resection) of the stomach. (Dorland, 28th ed)
Recording of the moment-to-moment electromotive forces of the HEART as projected onto various sites on the body's surface, delineated as a scalar function of time. The recording is monitored by a tracing on slow moving chart paper or by observing it on a cardioscope, which is a CATHODE RAY TUBE DISPLAY.
Procedures for finding the mathematical function which best describes the relationship between a dependent variable and one or more independent variables. In linear regression (see LINEAR MODELS) the relationship is constrained to be a straight line and LEAST-SQUARES ANALYSIS is used to determine the best fit. In logistic regression (see LOGISTIC MODELS) the dependent variable is qualitative rather than continuously variable and LIKELIHOOD FUNCTIONS are used to find the best relationship. In multiple regression, the dependent variable is considered to depend on more than a single independent variable.
Methods used for detecting the amplified DNA products from the polymerase chain reaction as they accumulate instead of at the end of the reaction.
Antineoplastic antibiotic obtained from Streptomyces peucetius. It is a hydroxy derivative of DAUNORUBICIN.
Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
Neoplasms of the brain and spinal cord derived from glial cells which vary from histologically benign forms to highly anaplastic and malignant tumors. Fibrillary astrocytomas are the most common type and may be classified in order of increasing malignancy (grades I through IV). In the first two decades of life, astrocytomas tend to originate in the cerebellar hemispheres; in adults, they most frequently arise in the cerebrum and frequently undergo malignant transformation. (From Devita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2013-7; Holland et al., Cancer Medicine, 3d ed, p1082)
A malignant neoplasm characterized by the formation of numerous, irregular, finger-like projections of fibrous stroma that is covered with a surface layer of neoplastic epithelial cells. (Stedman, 25th ed)
The total amount (cell number, weight, size or volume) of tumor cells or tissue in the body.
The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment.
Mapping of the KARYOTYPE of a cell.
Tumor suppressor genes located on the short arm of human chromosome 17 and coding for the phosphoprotein p53.
Care alleviating symptoms without curing the underlying disease. (Stedman, 25th ed)
A characteristic symptom complex.
Surgical excision of one or more lymph nodes. Its most common use is in cancer surgery. (From Dorland, 28th ed, p966)
Small double-stranded, non-protein coding RNAs, 21-25 nucleotides in length generated from single-stranded microRNA gene transcripts by the same RIBONUCLEASE III, Dicer, that produces small interfering RNAs (RNA, SMALL INTERFERING). They become part of the RNA-INDUCED SILENCING COMPLEX and repress the translation (TRANSLATION, GENETIC) of target RNA by binding to homologous 3'UTR region as an imperfect match. The small temporal RNAs (stRNAs), let-7 and lin-4, from C. elegans, are the first 2 miRNAs discovered, and are from a class of miRNAs involved in developmental timing.
RNA present in neoplastic tissue.
Radiotherapy given to augment some other form of treatment such as surgery or chemotherapy. Adjuvant radiotherapy is commonly used in the therapy of cancer and can be administered before or after the primary treatment.
A sarcoma originating in bone-forming cells, affecting the ends of long bones. It is the most common and most malignant of sarcomas of the bones, and occurs chiefly among 10- to 25-year-old youths. (From Stedman, 25th ed)
Tumors or cancer of the COLON.
Proteins that are normally involved in holding cellular growth in check. Deficiencies or abnormalities in these proteins may lead to unregulated cell growth and tumor development.
Tumors or cancer of the THYROID GLAND.
A statistical technique that isolates and assesses the contributions of categorical independent variables to variation in the mean of a continuous dependent variable.
The application of probability and statistical methods to calculate the risk of occurrence of any event, such as onset of illness, recurrent disease, hospitalization, disability, or death. It may include calculation of the anticipated money costs of such events and of the premiums necessary to provide for payment of such costs.
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
Truthful revelation of information, specifically when the information disclosed is likely to be psychologically painful ("bad news") to the recipient (e.g., revelation to a patient or a patient's family of the patient's DIAGNOSIS or PROGNOSIS) or embarrassing to the teller (e.g., revelation of medical errors).
A synthetic anti-inflammatory glucocorticoid derived from CORTISONE. It is biologically inert and converted to PREDNISOLONE in the liver.
Tumors or cancer of the PROSTATE.
An inorganic and water-soluble platinum complex. After undergoing hydrolysis, it reacts with DNA to produce both intra and interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity of cisplatin correlates with cellular arrest in the G2 phase of the cell cycle.
A positive regulatory effect on physiological processes at the molecular, cellular, or systemic level. At the molecular level, the major regulatory sites include membrane receptors, genes (GENE EXPRESSION REGULATION), mRNAs (RNA, MESSENGER), and proteins.
Any of a group of malignant tumors of lymphoid tissue that differ from HODGKIN DISEASE, being more heterogeneous with respect to malignant cell lineage, clinical course, prognosis, and therapy. The only common feature among these tumors is the absence of giant REED-STERNBERG CELLS, a characteristic of Hodgkin's disease.
Products of proto-oncogenes. Normally they do not have oncogenic or transforming properties, but are involved in the regulation or differentiation of cell growth. They often have protein kinase activity.
A class of statistical methods applicable to a large set of probability distributions used to test for correlation, location, independence, etc. In most nonparametric statistical tests, the original scores or observations are replaced by another variable containing less information. An important class of nonparametric tests employs the ordinal properties of the data. Another class of tests uses information about whether an observation is above or below some fixed value such as the median, and a third class is based on the frequency of the occurrence of runs in the data. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed, p1284; Corsini, Concise Encyclopedia of Psychology, 1987, p764-5)
The probability that an event will occur. It encompasses a variety of measures of the probability of a generally unfavorable outcome.
A spontaneous diminution or abatement of a disease over time, without formal treatment.
Tumors or cancer of the RECTUM.
A cell surface receptor involved in regulation of cell growth and differentiation. It is specific for EPIDERMAL GROWTH FACTOR and EGF-related peptides including TRANSFORMING GROWTH FACTOR ALPHA; AMPHIREGULIN; and HEPARIN-BINDING EGF-LIKE GROWTH FACTOR. The binding of ligand to the receptor causes activation of its intrinsic tyrosine kinase activity and rapid internalization of the receptor-ligand complex into the cell.
The genetic constitution of the individual, comprising the ALLELES present at each GENETIC LOCUS.
A mixed adenocarcinoma and squamous cell or epidermoid carcinoma.
Continuance of life or existence especially under adverse conditions; includes methods and philosophy of survival.
Exfoliate neoplastic cells circulating in the blood and associated with metastasizing tumors.
Neoplasms composed of glandular tissue, an aggregation of epithelial cells that elaborate secretions, and of any type of epithelium itself. The concept does not refer to neoplasms located in the various glands or in epithelial tissue.
Works about pre-planned studies of the safety, efficacy, or optimum dosage schedule (if appropriate) of one or more diagnostic, therapeutic, or prophylactic drugs, devices, or techniques selected according to predetermined criteria of eligibility and observed for predefined evidence of favorable and unfavorable effects. This concept includes clinical trials conducted both in the U.S. and in other countries.
A country spanning from central Asia to the Pacific Ocean.
Cells grown in vitro from neoplastic tissue. If they can be established as a TUMOR CELL LINE, they can be propagated in cell culture indefinitely.
Preliminary cancer therapy (chemotherapy, radiation therapy, hormone/endocrine therapy, immunotherapy, hyperthermia, etc.) that precedes a necessary second modality of treatment.
Neoplasms composed of primordial GERM CELLS of embryonic GONADS or of elements of the germ layers of the EMBRYO, MAMMALIAN. The concept does not refer to neoplasms located in the gonads or present in an embryo or FETUS.
Tumors or cancer of ENDOMETRIUM, the mucous lining of the UTERUS. These neoplasms can be benign or malignant. Their classification and grading are based on the various cell types and the percent of undifferentiated cells.
Biochemical identification of mutational changes in a nucleotide sequence.
Tumors or cancer of the URINARY BLADDER.
A type of chromosome aberration characterized by CHROMOSOME BREAKAGE and transfer of the broken-off portion to another location, often to a different chromosome.
Mutant mice homozygous for the recessive gene "nude" which fail to develop a thymus. They are useful in tumor studies and studies on immune responses.
A group of heterogeneous lymphoid tumors representing malignant transformations of T-lymphocytes.
A chronic leukemia characterized by abnormal B-lymphocytes and often generalized lymphadenopathy. In patients presenting predominately with blood and bone marrow involvement it is called chronic lymphocytic leukemia (CLL); in those predominately with enlarged lymph nodes it is called small lymphocytic lymphoma. These terms represent spectrums of the same disease.
Tumors or cancer of the NASOPHARYNX.
A profound state of unconsciousness associated with depressed cerebral activity from which the individual cannot be aroused. Coma generally occurs when there is dysfunction or injury involving both cerebral hemispheres or the brain stem RETICULAR FORMATION.
The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION.
Summarizing techniques used to describe the pattern of mortality and survival in populations. These methods can be applied to the study not only of death, but also of any defined endpoint such as the onset of disease or the occurrence of disease complications.
Neoplasms of the thin serous membrane that envelopes the lungs and lines the thoracic cavity. Pleural neoplasms are exceedingly rare and are usually not diagnosed until they are advanced because in the early stages they produce no symptoms.
Factors which produce cessation of all vital bodily functions. They can be analyzed from an epidemiologic viewpoint.
Proteins found in the nucleus of a cell. Do not confuse with NUCLEOPROTEINS which are proteins conjugated with nucleic acids, that are not necessarily present in the nucleus.
A general term for various neoplastic diseases of the lymphoid tissue.
Excision of all or part of the liver. (Dorland, 28th ed)
A glycoprotein that is secreted into the luminal surface of the epithelia in the gastrointestinal tract. It is found in the feces and pancreaticobiliary secretions and is used to monitor the response to colon cancer treatment.
Tumors or cancer of the GASTROINTESTINAL TRACT, from the MOUTH to the ANAL CANAL.
A group of heterogeneous lymphoid tumors generally expressing one or more B-cell antigens or representing malignant transformations of B-lymphocytes.
Methods to determine in patients the nature of a disease or disorder at its early stage of progression. Generally, early diagnosis improves PROGNOSIS and TREATMENT OUTCOME.
Statistical models which describe the relationship between a qualitative dependent variable (that is, one which can take only certain discrete values, such as the presence or absence of a disease) and an independent variable. A common application is in epidemiology for estimating an individual's risk (probability of a disease) as a function of a given risk factor.
The co-occurrence of pregnancy and NEOPLASMS. The neoplastic disease may precede or follow FERTILIZATION.
Cell changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm, and other attributes conferring the ability to invade, metastasize, and kill.
A vital statistic measuring or recording the rate of death from any cause in hospitalized populations.
The erbB-2 gene is a proto-oncogene that codes for the erbB-2 receptor (RECEPTOR, ERBB-2), a protein with structural features similar to the epidermal growth factor receptor. Its name originates from the viral oncogene homolog (v-erbB) which is a truncated form of the chicken erbB gene found in the avian erythroblastosis virus. Overexpression and amplification of the gene is associated with a significant number of adenocarcinomas. The human c-erbB-2 gene is located at 17q21.2.
Ultrasonic recording of the size, motion, and composition of the heart and surrounding tissues. The standard approach is transthoracic.
The confinement of a patient in a hospital.
Tumors or cancer of the UTERINE CERVIX.
Lymphocytes that show specificity for autologous tumor cells. Ex vivo isolation and culturing of TIL with interleukin-2, followed by reinfusion into the patient, is one form of adoptive immunotherapy of cancer.
The age, developmental stage, or period of life at which a disease or the initial symptoms or manifestations of a disease appear in an individual.
A condition in which the LEFT VENTRICLE of the heart was functionally impaired. This condition usually leads to HEART FAILURE; MYOCARDIAL INFARCTION; and other cardiovascular complications. Diagnosis is made by measuring the diminished ejection fraction and a depressed level of motility of the left ventricular wall.
A poorly differentiated adenocarcinoma in which the nucleus is pressed to one side by a cytoplasmic droplet of mucus. It usually arises in the gastrointestinal system.
The amount of BLOOD pumped out of the HEART per beat, not to be confused with cardiac output (volume/time). It is calculated as the difference between the end-diastolic volume and the end-systolic volume.
Small double-stranded, non-protein coding RNAs (21-31 nucleotides) involved in GENE SILENCING functions, especially RNA INTERFERENCE (RNAi). Endogenously, siRNAs are generated from dsRNAs (RNA, DOUBLE-STRANDED) by the same ribonuclease, Dicer, that generates miRNAs (MICRORNAS). The perfect match of the siRNAs' antisense strand to their target RNAs mediates RNAi by siRNA-guided RNA cleavage. siRNAs fall into different classes including trans-acting siRNA (tasiRNA), repeat-associated RNA (rasiRNA), small-scan RNA (scnRNA), and Piwi protein-interacting RNA (piRNA) and have different specific gene silencing functions.
The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.

Level of retinoblastoma protein expression correlates with p16 (MTS-1/INK4A/CDKN2) status in bladder cancer. (1/52363)

Recent studies have shown that patients whose bladder cancer exhibit overexpression of RB protein as measured by immunohistochemical analysis do equally poorly as those with loss of RB function. We hypothesized that loss of p16 protein function could be related to RB overexpression, since p16 can induce transcriptional downregulation of RB and its loss may lead to aberrant RB regulation. Conversely, loss of RB function has been associated with high p16 protein expression in several other tumor types. In the present study RB negative bladder tumors also exhibited strong nuclear p16 staining while each tumor with strong, homogeneous RB nuclear staining were p16 negative, supporting our hypothesis. To expand on these immunohistochemical studies additional cases were selected in which the status of the p16 encoding gene had been determined at the molecular level. Absent p16 and high RB protein expression was found in the tumors having loss of heterozygosity within 9p21 and a structural change (mutation or deletion) of the remaining p16 encoding gene allele, confirming the staining results. These results strongly support the hypothesis that the RB nuclear overexpression recently associated with poor prognosis in bladder cancer is also associated with loss of p16 function and implies that loss of p16 function could be equally deleterious as RB loss in bladder and likely other cancers.  (+info)

Expression of vascular endothelial growth factor in human oral squamous cell carcinoma: its association with tumour progression and p53 gene status. (2/52363)

AIMS: To correlate vascular endothelial growth factor (VEGF) expression in oral squamous cell carcinoma with the clinicopathological characteristics and prognosis; and to assess whether p53 gene status is associated with VEGF expression in human cancers. METHODS: Tumour specimens from 45 patients with oral squamous cell carcinomas were examined. Expression of VEGF was determined using an immunohistochemical method, and a tumour was considered positive when more than 5% of the neoplastic cells showed VEGF immunoreactivity. The p53 gene status was screened using a polymerase chain reaction--single strand conformation polymorphism analysis. RESULTS: VEGF positive staining was detected in 19 (42.2%) of the 45 cases. VEGF immunoreactivity did not correlate with the histological degree of tumour differentiation, clinical stages, or lymph node metastasis. The patients with VEGF positive tumours had a significantly worse prognosis than those with VEGF negative tumours. The five year overall survival rate of the VEGF negative patients was 76.5%, as compared with 48.8% for the VEGF positive patients. No significant association between VEGF expression and the p53 gene status of the tumours was found. CONCLUSIONS: VEGF is a good prognostic indicator of the survival of patients with oral squamous cell carcinoma. The p53 gene status does not seem to be associated with VEGF expression in these cancers.  (+info)

The role of alternative splicing of the adhesion molecule, CD44, in lymphoid malignancy. (3/52363)

AIM: To investigate the expression of CD44 isoforms containing variant exon 6 (v6) in a well characterised cohort of patients with non-Hodgkin's lymphoma (NHL) and chronic lymphocytic leukaemia (CLL), and to correlate this with phenotype and disease course. METHODS: Cryostat sections of OCT embedded diagnostic nodal material from NHL patients and cryopreserved mononuclear preparations from CLL patients were used as sources of RNA. After reverse transcription, PCR was carried out with amplimers positioned at either side of the variant exon insertion site to amplify all possible CD44 isoforms. Those isoforms containing v6 were identified after Southern blotting and hybridisation with a radiolabelled oligonucleotide. RESULTS: Of 32 NHL samples analysed, 16 did not express CD44 isoforms containing v6, six expressed an isoform containing exon v6 alone, and 10 expressed v6 long isoforms which contained exon v6 in addition to other variant exons. These data did not correlate with lymphoma classification, disease staging, or the presence or absence of extranodal disease. However, those patients expressing v6 long CD44 isoforms had a worse overall survival than those that did not. The plateau of the survival curves was 50% compared with 82%. No v6 long isoforms were detected in the 21 CLL samples investigated. CONCLUSIONS: The expression of v6 long CD44 isoforms is associated with aggressive disease in NHL, independent of grade, stage, or presence of extranodal disease.  (+info)

Is hospital care involved in inequalities in coronary heart disease mortality? Results from the French WHO-MONICA Project in men aged 30-64. (4/52363)

OBJECTIVES: The goal of the study was to assess whether possible disparities in coronary heart disease (CHD) management between occupational categories (OC) in men might be observed and contribute to the increasing inequalities in CHD morbidity and mortality reported in France. METHODS: The data from the three registers of the French MONICA Collaborative Centres (MCC-Lille, MCC-Strasbourg, and MCC-Toulouse) were analysed during two period: 1985-87 and 1989-91. Acute myocardial infarctions and coronary deaths concerning men, aged 30-64 years, were included. Non-professionally active and retired men were excluded. Results were adjusted for age and MCC, using a logistic regression analysis. RESULTS: 605 and 695 events were analysed for 1985-87 and 1989-91, respectively. Out of hospital cardiac arrests, with or without cardiac resuscitation, and 28 day case fatality rates were lower among upper executives in both periods. A coronarography before the acute event had been performed more frequently in men of this category and the proportion of events that could be hospitalised was higher among them. In both periods, the management of acute myocardial infarctions in hospital and prescriptions on discharge were similar among occupational categories. CONCLUSIONS: For patients who could be admitted to hospital, the management was found to be similar among OCs, as was the 28 day case fatality rate among the hospitalised patients. In contrast, lower prognosis and higher probability of being hospitalised after the event among some categories suggest that pre-hospital care and the patient's conditions before the event are the primary factors involved.  (+info)

Correlation between the status of the p53 gene and survival in patients with stage I non-small cell lung carcinoma. (5/52363)

The association of p53 abnormalities with the prognosis of patients with non-small cell lung carcinoma (NSCLC) has been extensively investigated to date, however, this association is still controversial. Therefore, we investigated the prognostic significance of p53 mutations through exons 2 to 11 and p53 protein expression in 103 cases of stage I NSCLC. p53 mutations were detected in 49 of 103 (48%) tumors. Two separate mutations were detected in four tumors giving a total of 53 unique mutations in 49 tumors. Ten (19%) of mutations occurred outside exons 5-8. Positive immunohistochemical staining of p53 protein was detected in 41 of 103 (40%) tumors. The concordance rate between mutations and protein overexpression was only 69%. p53 mutations, but not expression, were significantly associated with a shortened survival of patients (P<0.001). Furthermore, we investigated the correlation between the types of p53 mutations and prognosis. p53 missense mutations rather than null mutations were associated with poor prognosis (P < 0.001 in missense mutations and P=0.243 in null mutations). These results indicated that p53 mutations, in particular missense mutations, rather than p53 expression could be a useful molecular marker for the prognosis of patients with surgically resected stage I NSCLC.  (+info)

Intrahepatic recurrence after curative resection of hepatocellular carcinoma: long-term results of treatment and prognostic factors. (6/52363)

OBJECTIVE: This study aimed to evaluate the long-term results of treatment and prognostic factors in patients with intrahepatic recurrence after curative resection of hepatocellular carcinoma (HCC). SUMMARY BACKGROUND DATA: Recent studies have demonstrated the usefulness of re-resection, transarterial oily chemoembolization (TOCE), or percutaneous ethanol injection therapy (PEIT) in selected patients with intrahepatic recurrent HCC. The overall results of a treatment strategy combining these modalities have not been fully evaluated, and the prognostic factors determining survival in these patients remain to be clarified. METHODS: Two hundred and forty-four patients who underwent curative resection for HCC were followed for intrahepatic recurrence, which was treated aggressively with a strategy including different modalities. Survival results after recurrence and from initial hepatectomy were analyzed, and prognostic factors were determined by univariate and multivariate analysis using 27 clinicopathologic variables. RESULTS: One hundred and five patients (43%) with intrahepatic recurrence were treated with re-resection (11), TOCE (71), PEIT (6), systemic chemotherapy (8) or conservatively (9). The overall 1-year, 3-year, and 5-year survival rates from the time of recurrence were 65.5%, 34.9%, and 19.7%, respectively, and from the time of initial hepatectomy were 78.4%, 47.2%, and 30.9%, respectively. The re-resection group had the best survival, followed by the TOCE group. Multivariate analysis revealed Child's B or C grading, serum albumin < or = 40 g/l, multiple recurrent tumors, recurrence < or = 1 year after hepatectomy, and concurrent extrahepatic recurrence to be independent adverse prognostic factors. CONCLUSIONS: Aggressive treatment with a multimodality strategy could result in prolonged survival in patients with intrahepatic recurrence after curative resection for HCC. Prognosis was determined by the liver function status, interval to recurrence, number of recurrent tumors, any concurrent extrahepatic recurrence, and type of treatment.  (+info)

Surgery-related factors and local recurrence of Wilms tumor in National Wilms Tumor Study 4. (7/52363)

OBJECTIVE: To assess the prognostic factors for local recurrence in Wilms tumor. SUMMARY BACKGROUND DATA: Current therapy for Wilms tumor has evolved through four studies of the National Wilms Tumor Study Group. As adverse prognostic factors were identified, treatment of children with Wilms tumor has been tailored based on these factors. Two-year relapse-free survival of children in the fourth study (NWTS-4) exceeded 91%. Factors once of prognostic import for local recurrence may lose their significance as more effective therapeutic regimens are devised. METHODS: Children evaluated were drawn from the records of NWTS-4. A total of 2482 randomized or followed patients were identified. Local recurrence, defined as recurrence in the original tumor bed, retroperitoneum, or within the abdominal cavity or pelvis, occurred in 100 children. Using a nested case-control study design, 182 matched controls were selected. Factors were analyzed for their association with local failure. Relative risks and 95% confidence intervals were calculated, taking into account the matching. RESULTS: The largest relative risks for local recurrence were observed in patients with stage III disease, those with unfavorable histology (especially diffuse anaplasia), and those reported to have tumor spillage during surgery. Multiple regression analysis adjusting for the combined effects of histology, lymph node involvement, and age revealed that tumor spillage remained significant. The relative risk of local recurrence from spill was largest in children with stage II disease. The absence of lymph node biopsy was also associated with an increased relative risk of recurrence, which was largest in children with stage I disease. The survival of children after local recurrence is poor, with an average survival rate at 2 years after relapse of 43%. Survival was dependent on initial stage: those who received more therapy before relapse had a worse prognosis. CONCLUSIONS: This study has demonstrated that surgical rupture of the tumor must be prevented by the surgeon, because spills produce an increased risk of local relapse. Both local and diffuse spills produce this risk. Stage II children with local spill appear to require more aggressive therapy than that used in NWTS-4. The continued critical importance of lymph node sampling in conjunction with nephrectomy for Wilms tumor is also established. Absence of lymph node biopsy may result in understaging and inadequate treatment of the child and may produce an increased risk of local recurrence.  (+info)

Cardiovascular disease in insulin dependent diabetes mellitus: similar rates but different risk factors in the US compared with Europe. (8/52363)

BACKGROUND: Cardiovascular disease (CVD) in insulin dependent diabetes mellitus (IDDM) has been linked to renal disease. However, little is known concerning international variation in the correlations with hyperglycaemia and standard CVD risk factors. METHODS: A cross-sectional comparison was made of prevalence rates and risk factor associations in two large studies of IDDM subjects: the Pittsburgh Epidemiology of Diabetes Complications Study (EDC) and the EURODIAB IDDM Complications Study from 31 centres in Europe. Subgroups of each were chosen to be comparable by age and duration of diabetes. The EDC population comprises 286 men (mean duration 20.1 years) and 281 women (mean duration 19.9 years); EURODIAB 608 men (mean duration 18.1 years) and 607 women (mean duration 18.9 years). The mean age of both populations was 28 years. Cardiovascular disease was defined by a past medical history of myocardial infarction, angina, and/or the Minnesota ECG codes (1.1-1.3, 4.1-4.3, 5.1-5.3, 7.1). RESULTS: Overall prevalence of CVD was similar in the two populations (i.e. men 8.6% versus 8.0%, women 7.4% versus 8.5%, EURODIAB versus EDC respectively), although EDC women had a higher prevalence of angina (3.9% versus 0.5%, P < 0.001). Multivariate modelling suggests that glycaemic control (HbA1c) is not related to CVD in men. Age and high density lipoprotein cholesterol predict CVD in EURODIAB, while triglycerides and hypertension predict CVD in EDC. For women in both populations, age and hypertension (or renal disease) are independent predictors. HbA1c is also an independent predictor-inversely in EURODIAB women (P < 0.008) and positively in EDC women (P = 0.03). Renal disease was more strongly linked to CVD in EDC than in EURODIAB. CONCLUSIONS: Despite a similar prevalence of CVD, risk factor associations appear to differ in the two study populations. Glycaemic control (HbA1c) does not show a consistent or strong relationship to CVD.  (+info)

Breast neoplasms refer to abnormal growths or tumors in the breast tissue. These growths can be benign (non-cancerous) or malignant (cancerous). Benign breast neoplasms are usually not life-threatening, but they can cause discomfort or cosmetic concerns. Malignant breast neoplasms, on the other hand, can spread to other parts of the body and are considered a serious health threat. Some common types of breast neoplasms include fibroadenomas, ductal carcinoma in situ (DCIS), invasive ductal carcinoma, and invasive lobular carcinoma.

Lymphatic metastasis is a type of cancer spread that occurs when cancer cells from a primary tumor travel through the lymphatic system and spread to other parts of the body. The lymphatic system is a network of vessels and organs that helps to fight infection and remove waste products from the body. When cancer cells enter the lymphatic system, they can travel through the lymph nodes, which are small, bean-shaped structures that filter out harmful substances from the lymph fluid. If the cancer cells reach the lymph nodes, they can multiply and form new tumors, which can then spread to other parts of the body through the lymphatic system. Lymphatic metastasis is a common way for cancer to spread, and it can occur in many different types of cancer, including breast cancer, lung cancer, and colon cancer.

Adenocarcinoma is a type of cancer that starts in the glandular cells of an organ or tissue. It is one of the most common types of cancer and can occur in many different parts of the body, including the lungs, breast, colon, rectum, pancreas, stomach, and thyroid gland. Adenocarcinomas typically grow slowly and may not cause symptoms in the early stages. However, as the cancer grows, it can invade nearby tissues and spread to other parts of the body through the bloodstream or lymphatic system. This can lead to more serious symptoms and a higher risk of complications. Treatment for adenocarcinoma depends on the location and stage of the cancer, as well as the overall health of the patient. Options may include surgery, radiation therapy, chemotherapy, targeted therapy, or a combination of these approaches. The goal of treatment is to remove or destroy the cancer cells and prevent them from spreading further.

Disease progression refers to the worsening or progression of a disease over time. It is a natural course of events that occurs in many chronic illnesses, such as cancer, heart disease, and diabetes. Disease progression can be measured in various ways, such as changes in symptoms, physical examination findings, laboratory test results, or imaging studies. In some cases, disease progression can be slowed or stopped through medical treatment, such as medications, surgery, or radiation therapy. However, in other cases, disease progression may be inevitable, and the focus of treatment may shift from trying to cure the disease to managing symptoms and improving quality of life. Understanding disease progression is important for healthcare providers to develop effective treatment plans and to communicate with patients about their condition and prognosis. It can also help patients and their families make informed decisions about their care and treatment options.

In the medical field, "neoplasm invasiveness" refers to the ability of a cancerous tumor to invade and spread beyond its original site of origin. This can occur through the bloodstream or lymphatic system, or by direct extension into surrounding tissues. The degree of invasiveness of a neoplasm can be an important factor in determining the prognosis and treatment options for a patient. More invasive tumors are generally considered to be more aggressive and may be more difficult to treat. However, the specific characteristics of the tumor, such as its type, stage, and location, as well as the overall health of the patient, can also play a role in determining the prognosis. Invasive neoplasms may also be referred to as malignant tumors, as they have the potential to spread and cause harm to surrounding tissues and organs. Non-invasive neoplasms, on the other hand, are generally considered to be benign and are less likely to spread.

Neoplasm recurrence, local refers to the return of cancer cells to the original site of the tumor after treatment. This can occur even if the cancer has been completely removed through surgery or other treatments. Local recurrence is typically treated with additional surgery, radiation therapy, or chemotherapy, depending on the type and stage of the cancer. It is important to note that local recurrence does not necessarily mean that the cancer has spread to other parts of the body.

Lung neoplasms refer to abnormal growths or tumors that develop in the lungs. These growths can be either benign (non-cancerous) or malignant (cancerous). Lung neoplasms can occur in any part of the lung, including the bronchi, bronchioles, and alveoli. Lung neoplasms can be further classified based on their type, including: 1. Primary lung neoplasms: These are tumors that develop in the lungs and do not spread to other parts of the body. 2. Secondary lung neoplasms: These are tumors that develop in the lungs as a result of cancer that has spread from another part of the body. 3. Benign lung neoplasms: These are non-cancerous tumors that do not spread to other parts of the body. 4. Malignant lung neoplasms: These are cancerous tumors that can spread to other parts of the body. Some common types of lung neoplasms include lung adenocarcinoma, squamous cell carcinoma, large cell carcinoma, and small cell carcinoma. The diagnosis of lung neoplasms typically involves a combination of imaging tests, such as chest X-rays and CT scans, and a biopsy to examine a sample of tissue from the tumor. Treatment options for lung neoplasms depend on the type, size, and location of the tumor, as well as the overall health of the patient.

Carcinoma, Squamous Cell is a type of cancer that originates in the squamous cells, which are thin, flat cells that line the surface of the body. Squamous cells are found in the skin, mouth, throat, lungs, and other organs. Carcinoma, Squamous Cell can develop in any part of the body where squamous cells are present, but it is most commonly found in the head and neck, lungs, and skin. The exact cause of Squamous Cell Carcinoma is not always clear, but it is often associated with exposure to certain substances, such as tobacco smoke, alcohol, and certain chemicals. It can also develop as a result of chronic inflammation or infection, such as HPV (human papillomavirus) infection in the cervix. Symptoms of Squamous Cell Carcinoma can vary depending on the location of the tumor, but may include a persistent sore or lesion that does not heal, a change in the appearance of the skin or mucous membranes, difficulty swallowing or breathing, and unexplained weight loss. Treatment for Squamous Cell Carcinoma typically involves surgery to remove the tumor, followed by radiation therapy or chemotherapy to kill any remaining cancer cells. In some cases, targeted therapy or immunotherapy may also be used. The prognosis for Squamous Cell Carcinoma depends on the stage of the cancer at the time of diagnosis and the overall health of the patient.

Liver neoplasms refer to abnormal growths or tumors that develop in the liver. These growths can be either benign (non-cancerous) or malignant (cancerous). Benign liver neoplasms include hemangiomas, focal nodular hyperplasia, and adenomas. These growths are usually slow-growing and do not spread to other parts of the body. Malignant liver neoplasms, on the other hand, are more serious and include primary liver cancer (such as hepatocellular carcinoma) and secondary liver cancer (such as metastatic cancer from other parts of the body). These tumors can grow quickly and spread to other parts of the body, leading to serious health complications. Diagnosis of liver neoplasms typically involves imaging tests such as ultrasound, CT scan, or MRI, as well as blood tests and biopsy. Treatment options depend on the type and stage of the neoplasm, and may include surgery, chemotherapy, radiation therapy, or targeted therapy.

Neoplasm metastasis refers to the spread of cancer cells from a primary tumor to other parts of the body. This occurs when cancer cells break away from the primary tumor, enter the bloodstream or lymphatic system, and travel to distant organs or tissues, where they can form new tumors. Metastasis is a major cause of cancer-related deaths, as it makes the disease more difficult to treat and increases the risk of complications. The ability of cancer cells to metastasize is a key factor in determining the prognosis for patients with cancer.

Stomach neoplasms refer to abnormal growths or tumors that develop in the lining of the stomach. These growths can be either benign (non-cancerous) or malignant (cancerous). Stomach neoplasms can occur in different parts of the stomach, including the stomach lining, the muscular wall of the stomach, and the glands that produce stomach acid. Some common types of stomach neoplasms include gastric adenocarcinoma (a type of cancer that starts in the glandular cells of the stomach lining), gastric lymphoma (a type of cancer that starts in the lymphatic cells of the stomach), and gastric stromal tumors (benign tumors that develop in the connective tissue of the stomach). Stomach neoplasms can cause a variety of symptoms, including abdominal pain, nausea, vomiting, weight loss, and loss of appetite. Diagnosis typically involves a combination of medical history, physical examination, imaging tests (such as endoscopy or CT scan), and biopsy. Treatment for stomach neoplasms depends on the type, size, and location of the tumor, as well as the overall health of the patient. Treatment options may include surgery, chemotherapy, radiation therapy, or a combination of these approaches.

Carcinoma is a type of cancer that originates in the epithelial cells, which are the cells that line the surfaces of organs and tissues in the body. Carcinomas can develop in any part of the body, but they are most common in the skin, lungs, breast, prostate, and colon. Carcinomas are classified based on the location and type of epithelial cells from which they originate. For example, a carcinoma that develops in the skin is called a skin carcinoma, while a carcinoma that develops in the lungs is called a lung carcinoma. Carcinomas can be further classified as either non-melanoma skin cancers (such as basal cell carcinoma and squamous cell carcinoma) or melanoma, which is a more aggressive type of skin cancer that can spread to other parts of the body. Treatment for carcinomas depends on the type and stage of the cancer, as well as the overall health of the patient. Treatment options may include surgery, radiation therapy, chemotherapy, targeted therapy, or immunotherapy.

In the medical field, recurrence refers to the reappearance of a disease or condition after it has been treated or has gone into remission. Recurrence can occur in various medical conditions, including cancer, infections, and autoimmune diseases. For example, in cancer, recurrence means that the cancer has come back after it has been treated with surgery, chemotherapy, radiation therapy, or other treatments. Recurrence can occur months, years, or even decades after the initial treatment. In infections, recurrence means that the infection has returned after it has been treated with antibiotics or other medications. Recurrence can occur due to incomplete treatment, antibiotic resistance, or other factors. In autoimmune diseases, recurrence means that the symptoms of the disease return after they have been controlled with medication. Recurrence can occur due to changes in the immune system or other factors. Overall, recurrence is a significant concern for patients and healthcare providers, as it can require additional treatment and can impact the patient's quality of life.

Carcinoma, Hepatocellular is a type of cancer that originates in the liver cells, specifically in the cells that line the small blood vessels within the liver. It is the most common type of liver cancer and is often associated with chronic liver disease, such as cirrhosis or hepatitis B or C infection. The cancer cells in hepatocellular carcinoma can grow and spread to other parts of the body, including the lungs, bones, and lymph nodes. Symptoms of hepatocellular carcinoma may include abdominal pain, weight loss, jaundice (yellowing of the skin and eyes), and fatigue. Treatment options for hepatocellular carcinoma may include surgery, chemotherapy, radiation therapy, targeted therapy, and liver transplantation. The choice of treatment depends on the stage and location of the cancer, as well as the overall health of the patient.

Brain neoplasms, also known as brain tumors, are abnormal growths of cells in the brain. They can be either benign (non-cancerous) or malignant (cancerous). Brain tumors can occur in any part of the brain and can be primary (originating from brain cells) or secondary (spreading from other parts of the body to the brain). Symptoms of brain neoplasms can vary depending on the location and size of the tumor, but may include headaches, seizures, changes in vision or hearing, difficulty with balance or coordination, and changes in personality or behavior. Diagnosis of brain neoplasms typically involves a combination of imaging tests such as MRI or CT scans, as well as a biopsy to confirm the presence of cancer cells. Treatment options for brain neoplasms may include surgery, radiation therapy, chemotherapy, or a combination of these approaches. The specific treatment plan will depend on the type, location, and stage of the tumor, as well as the overall health of the patient.

Colorectal neoplasms refer to abnormal growths or tumors that develop in the colon or rectum. These growths can be either benign (non-cancerous) or malignant (cancerous). Colorectal neoplasms can be further classified into polyps, adenomas, and carcinomas. Polyps are non-cancerous growths that typically arise from the inner lining of the colon or rectum. Adenomas are a type of polyp that have the potential to become cancerous if left untreated. Carcinomas, on the other hand, are cancerous tumors that can invade nearby tissues and spread to other parts of the body. Colorectal neoplasms are a common health concern, and regular screening is recommended for individuals at high risk, such as those with a family history of colorectal cancer or those over the age of 50. Early detection and treatment of colorectal neoplasms can significantly improve outcomes and reduce the risk of complications.

Neoplasm proteins are proteins that are produced by cancer cells. These proteins are often abnormal and can contribute to the growth and spread of cancer. They can be detected in the blood or other body fluids, and their presence can be used as a diagnostic tool for cancer. Some neoplasm proteins are also being studied as potential targets for cancer treatment.

Esophageal neoplasms refer to abnormal growths or tumors that develop in the esophagus, which is the muscular tube that carries food from the throat to the stomach. These neoplasms can be either benign (non-cancerous) or malignant (cancerous). Benign esophageal neoplasms include polyps, which are small, non-cancerous growths that can develop on the lining of the esophagus. Other examples of benign neoplasms include leiomyomas, which are smooth muscle tumors, and lipomas, which are fatty tumors. Malignant esophageal neoplasms, on the other hand, are more serious and can be further classified into two main types: squamous cell carcinomas and adenocarcinomas. Squamous cell carcinomas develop in the squamous cells that line the esophagus, while adenocarcinomas develop in the glandular cells that line the lower part of the esophagus, near the stomach. Esophageal neoplasms can cause a range of symptoms, including difficulty swallowing, chest pain, weight loss, and difficulty breathing. Treatment options for esophageal neoplasms depend on the type, size, and location of the tumor, as well as the overall health of the patient. Treatment options may include surgery, radiation therapy, chemotherapy, or a combination of these approaches.

Receptor, erbB-2, also known as HER2 or neu, is a protein that is found on the surface of certain cells in the human body. It is a type of receptor tyrosine kinase, which means that it is a protein that is activated when it binds to a specific molecule, called a ligand. In the case of erbB-2, the ligand is a protein called epidermal growth factor (EGF). ErbB-2 is involved in a number of important cellular processes, including cell growth, differentiation, and survival. It is also a key player in the development of certain types of cancer, particularly breast cancer. In some cases, the erbB-2 gene may be overexpressed or mutated, leading to an overabundance of the erbB-2 protein on the surface of cancer cells. This can contribute to the uncontrolled growth and spread of the cancer. There are several ways that doctors can test for erbB-2 overexpression in breast cancer patients. One common method is to use a test called immunohistochemistry (IHC), which involves staining tissue samples with an antibody that binds specifically to the erbB-2 protein. If the erbB-2 protein is present in high levels, the tissue will appear dark under the microscope. Another method is to use a test called fluorescence in situ hybridization (FISH), which involves using a fluorescent probe to detect the presence of the erbB-2 gene on the cancer cells. If a patient's breast cancer is found to be positive for erbB-2 overexpression, they may be eligible for treatment with drugs called trastuzumab (Herceptin) or pertuzumab (Perjeta), which are designed to target the erbB-2 protein and help to shrink or stop the growth of the cancer. These drugs are often used in combination with other treatments, such as chemotherapy or radiation therapy.

Pancreatic neoplasms refer to abnormal growths or tumors that develop in the pancreas, a gland located in the abdomen behind the stomach. These neoplasms can be either benign (non-cancerous) or malignant (cancerous). Pancreatic neoplasms can occur in various parts of the pancreas, including the exocrine gland (which produces digestive enzymes), the endocrine gland (which produces hormones), and the ducts (which carry digestive juices from the pancreas to the small intestine). Symptoms of pancreatic neoplasms can vary depending on the location and size of the tumor, but may include abdominal pain, weight loss, jaundice (yellowing of the skin and eyes), nausea, vomiting, and unexplained fatigue. Diagnosis of pancreatic neoplasms typically involves imaging tests such as CT scans, MRI scans, or ultrasound, as well as blood tests and biopsies. Treatment options may include surgery, chemotherapy, radiation therapy, or a combination of these approaches, depending on the type and stage of the neoplasm.

Melanoma is a type of skin cancer that begins in the cells that produce the pigment melanin. It is the most dangerous type of skin cancer, as it has the potential to spread to other parts of the body and be difficult to treat. Melanoma can occur in any part of the body, but it most commonly appears on the skin as a new mole or a change in an existing mole. Other signs of melanoma may include a mole that is asymmetrical, has irregular borders, is a different color than the surrounding skin, is larger than a pencil eraser, or has a raised or scaly surface. Melanoma can also occur in the eye, mouth, and other parts of the body, and it is important to see a doctor if you have any concerning changes in your skin or other parts of your body.

In the medical field, an acute disease is a condition that develops suddenly and progresses rapidly over a short period of time. Acute diseases are typically characterized by severe symptoms and a high degree of morbidity and mortality. Examples of acute diseases include pneumonia, meningitis, sepsis, and heart attacks. These diseases require prompt medical attention and treatment to prevent complications and improve outcomes. In contrast, chronic diseases are long-term conditions that develop gradually over time and may persist for years or even decades.

Ki-67 is a protein found in the nuclei of cells that are actively dividing. It is a useful marker for assessing the growth rate of tumors and is often used in conjunction with other markers to help diagnose and predict the behavior of cancer. The Ki-67 antigen is named after the Danish pathologist, Kai Erik Nielsen, who first described it in the 1980s. It is typically measured using immunohistochemistry, a technique that uses antibodies to detect specific proteins in tissue samples.

Heart failure, also known as congestive heart failure, is a medical condition in which the heart is unable to pump enough blood to meet the body's needs. This can lead to a buildup of fluid in the lungs, liver, and other organs, causing symptoms such as shortness of breath, fatigue, and swelling in the legs and ankles. Heart failure can be caused by a variety of factors, including damage to the heart muscle from a heart attack, high blood pressure, or long-term damage from conditions such as diabetes or coronary artery disease. It can also be caused by certain genetic disorders or infections. Treatment for heart failure typically involves medications to improve heart function and reduce fluid buildup, as well as lifestyle changes such as a healthy diet, regular exercise, and avoiding smoking and excessive alcohol consumption. In some cases, surgery or other medical procedures may be necessary to treat the underlying cause of the heart failure or to improve heart function.

Ovarian neoplasms refer to abnormal growths or tumors that develop in the ovaries, which are the female reproductive organs responsible for producing eggs and hormones. These neoplasms can be either benign (non-cancerous) or malignant (cancerous), and they can vary in size, shape, and location within the ovaries. Ovarian neoplasms can be classified based on their histological type, which refers to the type of cells that make up the tumor. Some common types of ovarian neoplasms include epithelial ovarian cancer, germ cell tumors, sex cord-stromal tumors, and stromal tumors. Symptoms of ovarian neoplasms may include abdominal pain, bloating, pelvic pain, and changes in menstrual patterns. However, many ovarian neoplasms are asymptomatic and are discovered incidentally during routine pelvic exams or imaging studies. Diagnosis of ovarian neoplasms typically involves a combination of imaging studies, such as ultrasound or CT scans, and blood tests to measure levels of certain hormones and tumor markers. A biopsy may also be performed to confirm the diagnosis and determine the type and stage of the neoplasm. Treatment for ovarian neoplasms depends on the type, stage, and location of the tumor, as well as the patient's overall health and preferences. Options may include surgery, chemotherapy, radiation therapy, or a combination of these approaches. Early detection and treatment are crucial for improving outcomes and survival rates for patients with ovarian neoplasms.

Receptors, estrogen are proteins found on the surface of cells in the body that bind to and respond to the hormone estrogen. Estrogen is a sex hormone that is primarily produced by the ovaries in women and by the testes in men. It plays a key role in the development and regulation of the female reproductive system, as well as in the development of secondary sexual characteristics in both men and women. Estrogen receptors are classified into two main types: estrogen receptor alpha (ERα) and estrogen receptor beta (ERβ). These receptors are found in a wide variety of tissues throughout the body, including the breast, uterus, bone, and brain. When estrogen binds to its receptors, it triggers a cascade of chemical reactions within the cell that can have a variety of effects, depending on the type of receptor and the tissue in which it is found. In the breast, for example, estrogen receptors play a role in the development and growth of breast tissue, as well as in the regulation of the menstrual cycle. In the uterus, estrogen receptors are involved in the thickening of the uterine lining in preparation for pregnancy. In the bone, estrogen receptors help to maintain bone density and prevent osteoporosis. In the brain, estrogen receptors are involved in a variety of functions, including mood regulation, memory, and learning. Abnormalities in estrogen receptor function or expression have been linked to a number of health conditions, including breast cancer, uterine cancer, osteoporosis, and mood disorders.

Adenocarcinoma, mucinous is a type of cancer that starts in the glandular cells of the body's tissues and produces a large amount of mucus. It is a subtype of adenocarcinoma, which is a type of cancer that begins in the glandular cells that produce mucus, sweat, or other fluids. Mucinous adenocarcinomas are often found in the digestive system, such as the colon, stomach, and pancreas, but they can also occur in other parts of the body, such as the lungs, ovaries, and breast. They are typically slow-growing and may not cause symptoms until they are advanced. Treatment for mucinous adenocarcinoma may include surgery, chemotherapy, and radiation therapy, depending on the location and stage of the cancer.

In the medical field, neoplasms refer to abnormal growths or tumors of cells that can occur in any part of the body. These growths can be either benign (non-cancerous) or malignant (cancerous). Benign neoplasms are usually slow-growing and do not spread to other parts of the body. They can cause symptoms such as pain, swelling, or difficulty moving the affected area. Examples of benign neoplasms include lipomas (fatty tumors), hemangiomas (vascular tumors), and fibromas (fibrous tumors). Malignant neoplasms, on the other hand, are cancerous and can spread to other parts of the body through the bloodstream or lymphatic system. They can cause a wide range of symptoms, depending on the location and stage of the cancer. Examples of malignant neoplasms include carcinomas (cancers that start in epithelial cells), sarcomas (cancers that start in connective tissue), and leukemias (cancers that start in blood cells). The diagnosis of neoplasms typically involves a combination of physical examination, imaging tests (such as X-rays, CT scans, or MRI scans), and biopsy (the removal of a small sample of tissue for examination under a microscope). Treatment options for neoplasms depend on the type, stage, and location of the cancer, as well as the patient's overall health and preferences.

Carcinoma, Non-Small-Cell Lung (NSCLC) is a type of lung cancer that starts in the cells that line the airways or the alveoli (tiny air sacs) in the lungs. NSCLC is the most common type of lung cancer, accounting for about 85% of all lung cancer cases. NSCLC is further classified into three subtypes: adenocarcinoma, squamous cell carcinoma, and large cell carcinoma. Adenocarcinoma is the most common subtype of NSCLC and is often associated with long-term exposure to tobacco smoke or other environmental factors. Squamous cell carcinoma is also associated with smoking, while large cell carcinoma is less common and can occur in both smokers and non-smokers. Treatment options for NSCLC depend on the stage of the cancer, the patient's overall health, and other factors. Treatment may include surgery, radiation therapy, chemotherapy, targeted therapy, or a combination of these approaches. The goal of treatment is to remove or destroy the cancer cells and prevent them from spreading to other parts of the body.

Tumor suppressor protein p53 is a protein that plays a crucial role in regulating cell growth and preventing the development of cancer. It is encoded by the TP53 gene and is one of the most commonly mutated genes in human cancer. The p53 protein acts as a "guardian of the genome" by detecting DNA damage and initiating a series of cellular responses to repair the damage or trigger programmed cell death (apoptosis) if the damage is too severe. This helps to prevent the accumulation of mutations in the DNA that can lead to the development of cancer. In addition to its role in preventing cancer, p53 also plays a role in regulating cell cycle progression, DNA repair, and the response to cellular stress. Mutations in the TP53 gene can lead to the production of a non-functional or mutated p53 protein, which can result in the loss of these important functions and contribute to the development of cancer. Overall, the p53 protein is a critical regulator of cell growth and survival, and its dysfunction is a common feature of many types of cancer.

Myocardial infarction (MI), also known as a heart attack, is a medical condition that occurs when blood flow to a part of the heart muscle is blocked, usually by a blood clot. This lack of blood flow can cause damage to the heart muscle, which can lead to serious complications and even death if not treated promptly. The most common cause of a heart attack is atherosclerosis, a condition in which plaque builds up in the arteries that supply blood to the heart. When a plaque ruptures or becomes unstable, it can form a blood clot that blocks the flow of blood to the heart muscle. Other causes of heart attacks include coronary artery spasms, blood clots that travel to the heart from other parts of the body, and certain medical conditions such as Kawasaki disease. Symptoms of a heart attack may include chest pain or discomfort, shortness of breath, nausea or vomiting, lightheadedness or dizziness, and pain or discomfort in the arms, back, neck, jaw, or stomach. If you suspect that you or someone else is having a heart attack, it is important to call emergency services immediately. Early treatment with medications and possibly surgery can help to reduce the risk of serious complications and improve the chances of a full recovery.

DNA, or deoxyribonucleic acid, is a molecule that carries genetic information in living organisms. It is composed of four types of nitrogen-containing molecules called nucleotides, which are arranged in a specific sequence to form the genetic code. Neoplasm refers to an abnormal growth of cells in the body, which can be either benign (non-cancerous) or malignant (cancerous). Neoplasms can occur in any part of the body and can be caused by a variety of factors, including genetic mutations, exposure to carcinogens, and hormonal imbalances. In the medical field, DNA and neoplasms are closely related because many types of cancer are caused by mutations in the DNA of cells. These mutations can lead to uncontrolled cell growth and the formation of tumors. DNA analysis is often used to diagnose and treat cancer, as well as to identify individuals who are at increased risk of developing the disease.

Skin neoplasms refer to abnormal growths or tumors that develop on the skin. These growths can be benign (non-cancerous) or malignant (cancerous). Skin neoplasms can occur anywhere on the body and can vary in size, shape, and color. Some common types of skin neoplasms include basal cell carcinoma, squamous cell carcinoma, melanoma, and keratosis. These growths can be treated with a variety of methods, including surgery, radiation therapy, chemotherapy, and immunotherapy. It is important to have any unusual skin growths evaluated by a healthcare professional to determine the best course of treatment.

Kidney neoplasms refer to abnormal growths or tumors that develop in the kidneys. These tumors can be either benign (non-cancerous) or malignant (cancerous). Kidney neoplasms are also known as renal neoplasms or renal tumors. There are several types of kidney neoplasms, including: 1. Renal cell carcinoma (RCC): This is the most common type of kidney cancer and accounts for about 80-90% of all kidney neoplasms. 2. Wilms tumor: This is a type of kidney cancer that is most common in children. 3. Angiomyolipoma: This is a benign tumor that is made up of fat, smooth muscle, and blood vessels. 4. Oncocytoma: This is a benign tumor that is made up of cells that resemble normal kidney cells. 5. Papillary renal cell carcinoma: This is a type of kidney cancer that is less common than RCC but has a better prognosis. 6. Clear cell renal cell carcinoma: This is a type of kidney cancer that is the most common in adults and has a poor prognosis. The diagnosis of kidney neoplasms typically involves imaging tests such as ultrasound, CT scan, or MRI, as well as a biopsy to confirm the type and stage of the tumor. Treatment options for kidney neoplasms depend on the type, size, and stage of the tumor, as well as the overall health of the patient. Treatment options may include surgery, radiation therapy, chemotherapy, or targeted therapy.

In the medical field, RNA, Messenger (mRNA) refers to a type of RNA molecule that carries genetic information from DNA in the nucleus of a cell to the ribosomes, where proteins are synthesized. During the process of transcription, the DNA sequence of a gene is copied into a complementary RNA sequence called messenger RNA (mRNA). This mRNA molecule then leaves the nucleus and travels to the cytoplasm of the cell, where it binds to ribosomes and serves as a template for the synthesis of a specific protein. The sequence of nucleotides in the mRNA molecule determines the sequence of amino acids in the protein that is synthesized. Therefore, changes in the sequence of nucleotides in the mRNA molecule can result in changes in the amino acid sequence of the protein, which can affect the function of the protein and potentially lead to disease. mRNA molecules are often used in medical research and therapy as a way to introduce new genetic information into cells. For example, mRNA vaccines work by introducing a small piece of mRNA that encodes for a specific protein, which triggers an immune response in the body.

Receptors, Progesterone are proteins found on the surface of cells in the body that bind to the hormone progesterone. These receptors play a crucial role in regulating the menstrual cycle, maintaining pregnancy, and supporting the development of the fetus. When progesterone binds to its receptors, it triggers a series of chemical reactions within the cell that can have a variety of effects, depending on the type of cell and the tissue in which it is found. For example, progesterone receptors in the uterus help to thicken the lining of the uterus in preparation for a potential pregnancy, while receptors in the brain can help to regulate mood and behavior.

Cholangiocarcinoma is a type of cancer that develops in the bile ducts, which are the tubes that carry bile from the liver to the small intestine. It is a rare but aggressive form of cancer that can occur in the liver, bile ducts in the liver, or the bile ducts outside the liver. Cholangiocarcinoma can be classified into two main types: intrahepatic cholangiocarcinoma (which occurs within the liver) and extrahepatic cholangiocarcinoma (which occurs outside the liver, in the bile ducts that connect the liver to the small intestine). Symptoms of cholangiocarcinoma may include jaundice (yellowing of the skin and eyes), abdominal pain, weight loss, fever, and fatigue. Diagnosis typically involves imaging tests such as ultrasound, CT scan, or MRI, as well as a biopsy to confirm the presence of cancer cells. Treatment for cholangiocarcinoma may include surgery, chemotherapy, radiation therapy, or a combination of these approaches. The prognosis for cholangiocarcinoma depends on several factors, including the stage of the cancer at diagnosis, the location of the tumor, and the patient's overall health.

Bile duct neoplasms refer to tumors that develop in the bile ducts, which are the tubes that carry bile from the liver to the small intestine. These tumors can be either benign or malignant, and they can occur in any part of the bile duct system, including the intrahepatic bile ducts (which are located within the liver), the extrahepatic bile ducts (which are located outside the liver), and the ampulla of Vater (which is the point where the common bile duct and the main pancreatic duct join). Bile duct neoplasms can present with a variety of symptoms, depending on the location and size of the tumor. Some common symptoms include jaundice (yellowing of the skin and eyes), abdominal pain, weight loss, and fever. Diagnosis typically involves imaging studies such as ultrasound, CT scan, or MRI, as well as biopsy to confirm the presence of cancer cells. Treatment for bile duct neoplasms depends on the type and stage of the tumor, as well as the overall health of the patient. Options may include surgery, chemotherapy, radiation therapy, or a combination of these approaches. The prognosis for bile duct neoplasms varies widely, depending on the specific type and stage of the tumor, as well as the patient's age, overall health, and response to treatment.

Carcinoma, ductal, breast is a type of cancer that starts in the milk ducts of the breast. It is the most common type of breast cancer, accounting for about 80% of all breast cancer cases. Ductal carcinoma in situ (DCIS) is a non-invasive form of this cancer, where cancer cells are found in the lining of the milk ducts but have not spread to nearby tissues or lymph nodes. Invasive ductal carcinoma (IDC) is a more advanced form of the cancer, where cancer cells have invaded the surrounding breast tissue. The diagnosis of ductal carcinoma is usually made through a combination of a physical examination, imaging tests such as mammography or ultrasound, and a biopsy to confirm the presence of cancer cells. Treatment options for ductal carcinoma may include surgery, radiation therapy, chemotherapy, hormone therapy, or a combination of these approaches, depending on the stage and severity of the cancer.

Chromosome aberrations refer to changes or abnormalities in the structure or number of chromosomes in a cell. These changes can occur naturally during cell division or as a result of exposure to mutagens such as radiation or certain chemicals. Chromosome aberrations can be classified into several types, including deletions, duplications, inversions, translocations, and aneuploidy. These changes can have significant effects on the function of the affected cells and can lead to a variety of medical conditions, including cancer, genetic disorders, and birth defects. In the medical field, chromosome aberrations are often studied as a way to understand the genetic basis of disease and to develop new treatments.

Glioblastoma is a type of brain tumor that is classified as a grade IV astrocytoma, which means it is a highly aggressive and rapidly growing cancer. It is the most common and deadly type of primary brain tumor in adults, accounting for about 15% of all brain tumors. Glioblastoma typically arises from the supportive cells of the brain called astrocytes, but it can also develop from other types of brain cells. The tumor is characterized by its ability to infiltrate and spread into the surrounding brain tissue, making it difficult to remove completely through surgery. Symptoms of glioblastoma can vary depending on the location of the tumor in the brain, but common symptoms include headaches, seizures, nausea, vomiting, memory loss, and changes in personality or behavior. Treatment for glioblastoma typically involves a combination of surgery, radiation therapy, and chemotherapy. Despite these treatments, glioblastoma is generally considered to be incurable, with a median survival rate of about 15 months from diagnosis.

Neuroblastoma is a type of cancer that develops from immature nerve cells, called neuroblasts, in the sympathetic nervous system. It is most commonly found in children, although it can also occur in adults. Neuroblastoma can occur anywhere in the body where neuroblasts are present, but it most often affects the adrenal glands, the neck, and the chest. The symptoms of neuroblastoma can vary depending on the location and size of the tumor, but they may include abdominal pain, swelling, and a lump or mass in the abdomen or neck. Treatment for neuroblastoma typically involves a combination of surgery, chemotherapy, radiation therapy, and stem cell transplantation.

Bone neoplasms are abnormal growths or tumors that develop in the bones. They can be either benign (non-cancerous) or malignant (cancerous). Benign bone neoplasms are usually slow-growing and do not spread to other parts of the body, while malignant bone neoplasms can be invasive and spread to other parts of the body through the bloodstream or lymphatic system. There are several types of bone neoplasms, including osteosarcoma, Ewing's sarcoma, chondrosarcoma, and multiple myeloma. These tumors can affect any bone in the body, but they are most commonly found in the long bones of the arms and legs, such as the femur and tibia. Symptoms of bone neoplasms may include pain, swelling, and tenderness in the affected bone, as well as bone fractures that do not heal properly. Diagnosis typically involves imaging tests such as X-rays, MRI scans, and CT scans, as well as a biopsy to examine a sample of the tumor tissue. Treatment for bone neoplasms depends on the type and stage of the tumor, as well as the patient's overall health. Options may include surgery to remove the tumor, radiation therapy to kill cancer cells, chemotherapy to shrink the tumor, and targeted therapy to block the growth of cancer cells. In some cases, a combination of these treatments may be used.

Lymphoma, Large B-Cell, Diffuse is a type of cancer that affects the lymphatic system, which is a part of the immune system. It is characterized by the uncontrolled growth of abnormal B cells, which are a type of white blood cell that helps the body fight infections. In diffuse large B-cell lymphoma (DLBCL), the cancer cells are found throughout the lymph nodes and other lymphoid tissues, such as the spleen and bone marrow. This type of lymphoma is often aggressive and can spread quickly to other parts of the body. DLBCL is typically diagnosed through a combination of physical examination, imaging tests, and a biopsy of the affected tissue. Treatment options for DLBCL may include chemotherapy, radiation therapy, and targeted therapy, as well as stem cell transplantation in some cases. The prognosis for DLBCL depends on various factors, including the stage of the cancer at diagnosis and the patient's overall health.

Carcinoma, Renal Cell is a type of cancer that originates in the cells of the kidney. It is also known as renal cell carcinoma or RCC. These cells are found in the lining of small tubes in the kidney called nephrons, and when they become cancerous, they can grow and spread to other parts of the body. Renal cell carcinoma is the most common type of kidney cancer in adults, and it is more common in men than in women. The exact cause of RCC is not known, but risk factors include smoking, obesity, high blood pressure, and a family history of the disease. Symptoms of RCC may include blood in the urine, a lump or swelling in the abdomen, back pain, and fatigue. Diagnosis typically involves imaging tests such as CT scans or MRI scans, as well as a biopsy to confirm the presence of cancer cells. Treatment for RCC may include surgery to remove the affected kidney or part of the kidney, radiation therapy, chemotherapy, or immunotherapy. The choice of treatment depends on the stage and location of the cancer, as well as the overall health of the patient.

Gallbladder neoplasms refer to abnormal growths or tumors that develop in the gallbladder, a small organ located in the upper right part of the abdomen. These neoplasms can be either benign (non-cancerous) or malignant (cancerous). Benign gallbladder neoplasms include polyps, which are small, non-cancerous growths that can develop on the lining of the gallbladder. These polyps are usually asymptomatic and are often discovered incidentally during imaging studies for other conditions. Malignant gallbladder neoplasms, on the other hand, are less common but more serious. These include gallbladder cancer, which can be either primary (occurring in the gallbladder) or secondary (occurring as a result of cancer that has spread from another part of the body to the gallbladder). Symptoms of gallbladder neoplasms may include abdominal pain, jaundice (yellowing of the skin and eyes), nausea, vomiting, and weight loss. Diagnosis typically involves imaging studies such as ultrasound, CT scan, or MRI, as well as biopsy to confirm the presence of a neoplasm. Treatment for gallbladder neoplasms depends on the type and stage of the tumor, as well as the overall health of the patient. Options may include surgery to remove the affected organ, chemotherapy, radiation therapy, or a combination of these approaches.

Sarcoma is a type of cancer that arises from connective tissue, including bone, cartilage, fat, muscle, and other tissues. Sarcomas can occur in any part of the body, but they are most common in the arms, legs, trunk, and head and neck. Sarcomas are classified based on the type of tissue from which they arise and the specific characteristics of the cancer cells. There are more than 100 different types of sarcomas, and they can be further divided into two main categories: soft tissue sarcomas and bone sarcomas. Soft tissue sarcomas are cancers that develop in the soft tissues of the body, such as muscle, fat, and connective tissue. They can occur anywhere in the body, but they are most common in the arms, legs, and trunk. Bone sarcomas, on the other hand, are cancers that develop in the bones of the body. They are less common than soft tissue sarcomas and can occur in any bone, but they are most common in the long bones of the arms and legs. Sarcomas can be treated with a variety of approaches, including surgery, radiation therapy, chemotherapy, and targeted therapy. The specific treatment plan will depend on the type and stage of the cancer, as well as the patient's overall health and preferences.

Glioma is a type of brain tumor that arises from the glial cells, which are the supportive cells of the brain and spinal cord. Gliomas are the most common type of primary brain tumor, accounting for about 80% of all brain tumors. They can occur in any part of the brain, but are most commonly found in the frontal and temporal lobes. Gliomas are classified based on their degree of malignancy, with grades I to IV indicating increasing levels of aggressiveness. Grade I gliomas are slow-growing and have a better prognosis, while grade IV gliomas are highly aggressive and have a poor prognosis. Symptoms of gliomas can vary depending on the location and size of the tumor, but may include headaches, seizures, changes in vision or speech, difficulty with coordination or balance, and personality changes. Treatment options for gliomas may include surgery, radiation therapy, chemotherapy, and targeted therapy, depending on the type and stage of the tumor.

Vincristine is a chemotherapy drug that is used to treat various types of cancer, including leukemia, lymphoma, and neuroblastoma. It works by interfering with the growth and division of cancer cells, which can slow or stop the growth of tumors. Vincristine is usually administered intravenously, and its side effects can include nausea, vomiting, hair loss, and damage to the nerves that control movement. It is also known by the brand name Oncovin.

Acute Myeloid Leukemia (AML) is a type of cancer that affects the bone marrow and blood cells. It is characterized by the rapid growth of abnormal white blood cells, called myeloid cells, in the bone marrow. These abnormal cells do not function properly and can crowd out healthy blood cells, leading to a variety of symptoms such as fatigue, weakness, and frequent infections. AML can occur in people of all ages, but it is most common in adults over the age of 60. Treatment for AML typically involves chemotherapy, radiation therapy, and/or stem cell transplantation.

Mouth neoplasms refer to abnormal growths or tumors that develop in the mouth, including the lips, tongue, gums, palate, and throat. These growths can be benign (non-cancerous) or malignant (cancerous), and they can occur in any part of the mouth. Mouth neoplasms can be further classified based on their type, including: 1. Squamous cell carcinoma: This is the most common type of mouth cancer and usually develops on the lips, tongue, or floor of the mouth. 2. Adenoid cystic carcinoma: This type of cancer usually develops in the salivary glands and can spread to other parts of the mouth and neck. 3. Mucoepidermoid carcinoma: This is a rare type of cancer that develops in the salivary glands and can spread to other parts of the mouth and neck. 4. Basal cell carcinoma: This type of cancer usually develops on the lips and can spread to other parts of the mouth and neck. 5. Melanoma: This is a type of cancer that develops in the melanocytes (pigment-producing cells) of the mouth. Mouth neoplasms can cause a variety of symptoms, including pain, difficulty swallowing, changes in the appearance of the mouth, and bleeding. Treatment options for mouth neoplasms depend on the type, size, and location of the tumor, as well as the overall health of the patient. Treatment may include surgery, radiation therapy, chemotherapy, or a combination of these approaches.

Head and neck neoplasms refer to tumors that develop in the head and neck region of the body. These tumors can be benign (non-cancerous) or malignant (cancerous) and can affect any part of the head and neck, including the mouth, nose, throat, sinuses, salivary glands, thyroid gland, and neck lymph nodes. Head and neck neoplasms can be further classified based on the type of tissue they arise from, such as squamous cell carcinoma (which develops from the squamous cells that line the inside of the mouth and throat), adenoid cystic carcinoma (which develops from the glands that produce mucus), and salivary gland tumors (which develop from the salivary glands). The treatment for head and neck neoplasms depends on the type, size, location, and stage of the tumor, as well as the overall health of the patient. Treatment options may include surgery, radiation therapy, chemotherapy, targeted therapy, and immunotherapy. Early detection and treatment are crucial for improving the prognosis and reducing the risk of complications.

Carcinoma, Pancreatic Ductal is a type of cancer that originates in the cells lining the pancreatic ducts, which are the tubes that carry digestive enzymes and bicarbonate from the pancreas to the small intestine. This type of cancer is also known as pancreatic ductal adenocarcinoma (PDAC) or pancreatic cancer. It is the most common type of pancreatic cancer and is usually diagnosed at an advanced stage, making it difficult to treat. The symptoms of pancreatic ductal carcinoma may include abdominal pain, weight loss, jaundice, and nausea. Treatment options for this type of cancer may include surgery, chemotherapy, radiation therapy, and targeted therapy.

Cyclophosphamide is an immunosuppressive drug that is commonly used to treat various types of cancer, including lymphoma, leukemia, and multiple myeloma. It works by inhibiting the growth and division of cells, including cancer cells, and by suppressing the immune system. Cyclophosphamide is usually administered intravenously or orally, and its dosage and duration of treatment depend on the type and stage of cancer being treated, as well as the patient's overall health. Side effects of cyclophosphamide can include nausea, vomiting, hair loss, fatigue, and an increased risk of infection. It can also cause damage to the kidneys, bladder, and reproductive organs, and may increase the risk of developing certain types of cancer later in life.

Neovascularization, pathologic, refers to the abnormal growth of new blood vessels in the body. This can occur in response to a variety of factors, including injury, inflammation, and certain diseases. In some cases, neovascularization can be a normal part of the healing process, but in other cases it can be a sign of a more serious underlying condition. Pathologic neovascularization is often associated with conditions such as cancer, diabetes, and age-related macular degeneration. It can also be seen in the development of certain types of tumors, where the new blood vessels help to provide the tumor with the nutrients and oxygen it needs to grow. Treatment for pathologic neovascularization may involve medications, laser therapy, or surgery, depending on the underlying cause and the severity of the condition.

Precursor Cell Lymphoblastic Leukemia-Lymphoma (PCLL) is a type of cancer that affects the lymphatic system, which is a part of the immune system. It is a rare and aggressive form of acute lymphoblastic leukemia (ALL), which is a type of cancer that affects the white blood cells in the bone marrow. PCLL is characterized by the rapid growth and proliferation of immature white blood cells, called lymphoblasts, in the bone marrow, blood, and lymphatic system. These cells do not mature properly and are unable to carry out their normal functions, leading to a weakened immune system and an increased risk of infections. PCLL is typically diagnosed in children and young adults, and the symptoms may include fever, fatigue, weight loss, night sweats, and swollen lymph nodes. Treatment for PCLL typically involves chemotherapy, radiation therapy, and stem cell transplantation. The prognosis for PCLL is generally poor, but with appropriate treatment, some people are able to achieve remission and improve their quality of life.

Alpha-fetoprotein (AFP) is a protein that is produced by the yolk sac and the fetal liver during pregnancy. It is normally present in small amounts in the blood of pregnant women, but levels can increase if there is a problem with the fetus, such as a neural tube defect or a tumor. In adults, high levels of AFP can be a sign of liver disease, cancer, or other conditions. It is often used as a tumor marker in the diagnosis and monitoring of certain types of cancer, such as liver cancer and testicular cancer.

In the medical field, a chronic disease is a long-term health condition that persists for an extended period, typically for more than three months. Chronic diseases are often progressive, meaning that they tend to worsen over time, and they can have a significant impact on a person's quality of life. Chronic diseases can affect any part of the body and can be caused by a variety of factors, including genetics, lifestyle, and environmental factors. Some examples of chronic diseases include heart disease, diabetes, cancer, chronic obstructive pulmonary disease (COPD), and arthritis. Chronic diseases often require ongoing medical management, including medication, lifestyle changes, and regular monitoring to prevent complications and manage symptoms. Treatment for chronic diseases may also involve rehabilitation, physical therapy, and other supportive care.

Doxorubicin is an anthracycline chemotherapy drug that is used to treat a variety of cancers, including breast cancer, ovarian cancer, and leukemia. It works by interfering with the production of DNA and RNA, which are essential for the growth and division of cancer cells. Doxorubicin is usually administered intravenously, and its side effects can include nausea, vomiting, hair loss, and damage to the heart and kidneys. It is a powerful drug that can be effective against many types of cancer, but it can also have serious side effects, so it is typically used in combination with other treatments or in low doses.

Astrocytoma is a type of brain tumor that arises from astrocytes, which are star-shaped cells that support and nourish neurons in the brain. Astrocytomas are the most common type of primary brain tumor, accounting for about 30% of all brain tumors. They can occur at any age, but are most common in adults between the ages of 40 and 60. Astrocytomas are classified into four grades based on their degree of malignancy and ability to invade surrounding tissues. Grade I astrocytomas are slow-growing and low-grade, while grade IV astrocytomas are highly aggressive and fast-growing. Treatment options for astrocytomas depend on the grade of the tumor, the location of the tumor in the brain, and the patient's overall health. Treatment may include surgery, radiation therapy, chemotherapy, and targeted therapy.

Carcinoma, papillary refers to a type of cancer that originates in the cells lining a gland or duct, such as the thyroid gland or the breast. Papillary carcinomas are characterized by the presence of small, finger-like projections called papillae, which are a common feature of these types of tumors. These tumors are typically slow-growing and may not cause symptoms until they are quite large. Treatment for papillary carcinoma usually involves surgery to remove the affected gland or duct, followed by radiation therapy or chemotherapy to kill any remaining cancer cells. In some cases, hormone therapy may also be used to treat papillary carcinoma.

In the medical field, a syndrome is a set of symptoms and signs that occur together and suggest the presence of a particular disease or condition. A syndrome is often defined by a specific pattern of symptoms that are not caused by a single underlying disease, but rather by a combination of factors, such as genetic, environmental, or hormonal. For example, Down syndrome is a genetic disorder that is characterized by a specific set of physical and intellectual characteristics, such as a flattened facial profile, short stature, and intellectual disability. Similarly, the flu syndrome is a set of symptoms that occur together, such as fever, cough, sore throat, and body aches, that suggest the presence of an influenza virus infection. Diagnosing a syndrome involves identifying the specific set of symptoms and signs that are present, as well as ruling out other possible causes of those symptoms. Once a syndrome is diagnosed, it can help guide treatment and management of the underlying condition.

MicroRNAs (miRNAs) are small, non-coding RNA molecules that play a crucial role in regulating gene expression at the post-transcriptional level. They are typically 18-24 nucleotides in length and are transcribed from endogenous genes. In the medical field, miRNAs have been found to be involved in a wide range of biological processes, including cell growth, differentiation, apoptosis, and metabolism. Dysregulation of miRNA expression has been implicated in various diseases, including cancer, cardiovascular disease, neurological disorders, and infectious diseases. MiRNAs can act as either oncogenes or tumor suppressors, depending on the target gene they regulate. They can also be used as diagnostic and prognostic markers for various diseases, as well as therapeutic targets for the development of new drugs.

RNA, Neoplasm refers to the presence of abnormal RNA molecules in a neoplasm, which is a mass of abnormal cells that grow uncontrollably in the body. RNA is a type of genetic material that plays a crucial role in the regulation of gene expression and protein synthesis. In neoplasms, abnormal RNA molecules can be produced due to mutations in the DNA that codes for RNA. These abnormal RNA molecules can affect the normal functioning of cells and contribute to the development and progression of cancer. The detection and analysis of RNA in neoplasms can provide important information about the genetic changes that are occurring in the cells and can help guide the development of targeted therapies for cancer treatment.

Osteosarcoma is a type of cancer that starts in the cells that make up the bones. It is the most common type of bone cancer in children and adolescents, and it can occur in any bone in the body, but it most often affects the long bones of the arms and legs, such as the femur and tibia. Osteosarcoma usually develops in the metaphysis, which is the area of the bone where it is still growing and developing. The cancer cells can spread to the surrounding tissue and bone, and in some cases, they can also spread to other parts of the body through the bloodstream or lymphatic system. Symptoms of osteosarcoma may include pain and swelling in the affected bone, difficulty moving the affected joint, and the appearance of a lump or mass near the bone. Diagnosis is typically made through a combination of imaging tests, such as X-rays and MRI scans, and a biopsy to examine a sample of the tumor tissue. Treatment for osteosarcoma typically involves a combination of surgery, chemotherapy, and radiation therapy. The goal of treatment is to remove as much of the cancer as possible while minimizing damage to the surrounding healthy tissue. The prognosis for osteosarcoma depends on several factors, including the stage of the cancer at diagnosis, the location of the tumor, and the patient's overall health.

Colonic neoplasms refer to abnormal growths or tumors that develop in the colon, which is the final part of the large intestine. These growths can be either benign (non-cancerous) or malignant (cancerous). Benign colonic neoplasms include polyps, which are small, non-cancerous growths that can develop on the inner lining of the colon. Polyps can be further classified as adenomas, which are made up of glandular tissue, or hyperplastic polyps, which are non-glandular. Malignant colonic neoplasms, on the other hand, are cancerous tumors that can invade nearby tissues and spread to other parts of the body. The most common type of colon cancer is adenocarcinoma, which starts in the glandular tissue of the colon. Colonic neoplasms can be detected through various diagnostic tests, including colonoscopy, sigmoidoscopy, and fecal occult blood testing. Treatment options for colonic neoplasms depend on the type, size, and location of the growth, as well as the overall health of the patient. Early detection and treatment of colonic neoplasms can significantly improve the chances of a successful outcome.

Tumor suppressor proteins are a group of proteins that play a crucial role in regulating cell growth and preventing the development of cancer. These proteins act as brakes on the cell cycle, preventing cells from dividing and multiplying uncontrollably. They also help to repair damaged DNA and prevent the formation of tumors. Tumor suppressor proteins are encoded by genes that are located on specific chromosomes. When these genes are functioning properly, they produce proteins that help to regulate cell growth and prevent the development of cancer. However, when these genes are mutated or damaged, the proteins they produce may not function properly, leading to uncontrolled cell growth and the development of cancer. There are many different tumor suppressor proteins, each with its own specific function. Some of the most well-known tumor suppressor proteins include p53, BRCA1, and BRCA2. These proteins are involved in regulating cell cycle checkpoints, repairing damaged DNA, and preventing the formation of tumors. In summary, tumor suppressor proteins are a group of proteins that play a critical role in regulating cell growth and preventing the development of cancer. When these proteins are functioning properly, they help to maintain the normal balance of cell growth and division, but when they are mutated or damaged, they can contribute to the development of cancer.

Thyroid neoplasms refer to abnormal growths or tumors in the thyroid gland, which is a butterfly-shaped gland located in the neck. These neoplasms can be either benign (non-cancerous) or malignant (cancerous). Thyroid neoplasms can occur in any part of the thyroid gland, but some areas are more prone to developing tumors than others. The most common type of thyroid neoplasm is a thyroid adenoma, which is a benign tumor that arises from the follicular cells of the thyroid gland. Other types of thyroid neoplasms include papillary thyroid carcinoma, follicular thyroid carcinoma, medullary thyroid carcinoma, and anaplastic thyroid carcinoma. Thyroid neoplasms can cause a variety of symptoms, depending on the size and location of the tumor, as well as whether it is benign or malignant. Some common symptoms include a lump or swelling in the neck, difficulty swallowing, hoarseness, and a rapid or irregular heartbeat. Diagnosis of thyroid neoplasms typically involves a combination of physical examination, imaging studies such as ultrasound or CT scan, and biopsy of the thyroid tissue. Treatment options for thyroid neoplasms depend on the type, size, and location of the tumor, as well as the patient's overall health and age. Treatment may include surgery, radiation therapy, or medication to manage symptoms or slow the growth of the tumor.

Prednisone is a synthetic corticosteroid medication that is used to treat a variety of medical conditions, including allergies, autoimmune disorders, inflammatory diseases, and certain types of cancer. It works by reducing inflammation and suppressing the immune system, which can help to reduce symptoms and slow the progression of the disease. Prednisone is available in both oral and injectable forms, and it is typically prescribed in doses that are gradually increased or decreased over time, depending on the patient's response to the medication and the specific condition being treated. While prednisone can be effective in treating a wide range of medical conditions, it can also have side effects, including weight gain, mood changes, and increased risk of infections. Therefore, it is important for patients to work closely with their healthcare provider to monitor their response to the medication and adjust the dosage as needed.

Prostatic neoplasms refer to tumors that develop in the prostate gland, which is a small gland located in the male reproductive system. These tumors can be either benign (non-cancerous) or malignant (cancerous). Benign prostatic neoplasms, also known as benign prostatic hyperplasia (BPH), are the most common type of prostatic neoplasm and are typically associated with an increase in the size of the prostate gland. Malignant prostatic neoplasms, on the other hand, are more serious and can spread to other parts of the body if left untreated. The most common type of prostate cancer is adenocarcinoma, which starts in the glandular cells of the prostate. Other types of prostatic neoplasms include sarcomas, which are rare and start in the connective tissue of the prostate, and carcinoid tumors, which are rare and start in the neuroendocrine cells of the prostate.

Cisplatin is a chemotherapy drug that is commonly used to treat various types of cancer, including ovarian, testicular, bladder, and lung cancer. It works by binding to the DNA of cancer cells, which prevents them from dividing and growing. Cisplatin is usually administered intravenously and can cause a range of side effects, including nausea, vomiting, hair loss, and damage to the kidneys and hearing. It is important to note that cisplatin is not effective for all types of cancer and may not be suitable for everyone. The use of cisplatin should be determined by a healthcare professional based on the individual's specific medical needs and circumstances.

Lymphoma, Non-Hodgkin (NHL) is a type of cancer that affects the lymphatic system, which is a part of the immune system. NHL is characterized by the abnormal growth of lymphocytes, a type of white blood cell, in the lymph nodes, spleen, and other parts of the body. There are many different types of NHL, and they can vary in their symptoms, progression, and treatment options. Some common symptoms of NHL include swollen lymph nodes, fever, night sweats, weight loss, and fatigue. NHL is typically diagnosed through a combination of physical examination, blood tests, imaging studies, and a biopsy of the affected tissue. Treatment options for NHL may include chemotherapy, radiation therapy, targeted therapy, and stem cell transplantation, depending on the type and stage of the cancer. Overall, NHL is a serious condition that requires prompt diagnosis and treatment to improve outcomes and quality of life for patients.

Proto-oncogenes are normal genes that are involved in regulating cell growth and division. When these genes are mutated or overexpressed, they can become oncogenes, which can lead to the development of cancer. Proto-oncogenes are also known as proto-oncogene proteins.

In the medical field, "remission, spontaneous" refers to the natural recovery or improvement of a disease or condition without any specific treatment or intervention. It is a spontaneous return to a state of health or wellness that occurs without any external influence or medical intervention. Spontaneous remission can occur in various medical conditions, including cancer, autoimmune diseases, and mental health disorders. It is often seen as a positive outcome for patients, as it can reduce the need for medical treatment and improve their quality of life. However, it is important to note that spontaneous remission is not a guarantee of long-term recovery and that the underlying cause of the disease or condition may still be present. Therefore, it is essential to continue monitoring the patient's condition and seeking appropriate medical care as needed.

Rectal neoplasms refer to abnormal growths or tumors that develop in the rectum, which is the final section of the large intestine. These neoplasms can be either benign or malignant, and they can range in size and location within the rectum. Benign rectal neoplasms, also known as polyps, are non-cancerous growths that typically do not spread to other parts of the body. They can be either pedunculated, meaning they have a stalk that attaches them to the rectal wall, or sessile, meaning they are attached directly to the rectal wall. Malignant rectal neoplasms, also known as rectal cancers, are cancerous tumors that can invade nearby tissues and spread to other parts of the body through the bloodstream or lymphatic system. Rectal cancers can be either adenocarcinomas, which are the most common type, or squamous cell carcinomas, which are less common. Rectal neoplasms can cause a variety of symptoms, including rectal bleeding, changes in bowel habits, pain or discomfort in the rectum, and a feeling of incomplete bowel movements. Diagnosis typically involves a combination of physical examination, imaging studies, and biopsy. Treatment options for rectal neoplasms depend on the type, size, and location of the tumor, as well as the overall health of the patient.

The Epidermal Growth Factor Receptor (EGFR) is a type of cell surface receptor protein that is found on the surface of cells in the epidermis, as well as in other tissues throughout the body. The EGFR is a member of a family of receptors called receptor tyrosine kinases, which are involved in regulating cell growth, differentiation, and survival. When the EGFR binds to its ligand, a protein called epidermal growth factor (EGF), it triggers a cascade of intracellular signaling events that ultimately lead to the activation of various genes involved in cell growth and proliferation. This process is important for normal tissue growth and repair, but it can also contribute to the development of cancer when the EGFR is overactive or mutated. EGFR inhibitors are a class of drugs that are used to treat certain types of cancer, such as non-small cell lung cancer and head and neck cancer, by blocking the activity of the EGFR and preventing it from signaling downstream genes. These drugs can be used alone or in combination with other treatments, such as chemotherapy or radiation therapy.

Carcinoma, Adenosquamous is a type of cancer that arises from the cells that line the inside of certain organs, such as the lungs, bladder, and pancreas. These cells are called glandular cells, and they produce mucus or other substances that help to lubricate and protect the organs. Adenosquamous carcinoma is a rare type of cancer that arises when glandular cells and squamous cells, which are flat, scale-like cells that line the surface of organs, mix together and form a tumor. This type of cancer is often aggressive and can spread quickly to other parts of the body. Treatment for adenosquamous carcinoma typically involves surgery, radiation therapy, and chemotherapy.

In the medical field, "Neoplastic Cells, Circulating" refers to cancer cells that have detached from a primary tumor and entered the bloodstream or lymphatic system. These cells are also known as circulating tumor cells (CTCs) or circulating neoplastic cells (CNCs). When cancer cells enter the bloodstream, they can travel to distant parts of the body and form new tumors, a process known as metastasis. The presence of circulating neoplastic cells is an indicator of the potential for metastasis and can be used as a biomarker for cancer progression and treatment response. The detection and enumeration of circulating neoplastic cells is typically performed using specialized laboratory techniques, such as flow cytometry or immunohistochemistry. These tests can help doctors monitor the progression of cancer and guide treatment decisions.

In the medical field, "Neoplasms, Glandular and Epithelial" refers to abnormal growths or tumors that arise from glandular or epithelial cells. These types of neoplasms can occur in various organs and tissues throughout the body, including the breast, prostate, thyroid, and lungs. Glandular neoplasms are tumors that develop in glands, which are organs that produce and secrete substances such as hormones and enzymes. Examples of glandular neoplasms include breast cancer, prostate cancer, and thyroid cancer. Epithelial neoplasms, on the other hand, are tumors that develop in epithelial cells, which are the cells that line the inner and outer surfaces of organs and tissues. Examples of epithelial neoplasms include skin cancer, lung cancer, and colon cancer. Both glandular and epithelial neoplasms can be either benign (non-cancerous) or malignant (cancerous). Benign neoplasms typically do not spread to other parts of the body, while malignant neoplasms have the potential to invade nearby tissues and spread to other organs through the bloodstream or lymphatic system.

In the medical field, "Neoplasms, Germ Cell and Embryonal" refers to a group of tumors that arise from cells that are derived from the germ cells or embryonic cells. Germ cells are the cells that give rise to eggs and sperm, while embryonic cells are the cells that give rise to all the different types of cells in the body during development. Neoplasms, Germ Cell and Embryonal tumors can occur in various parts of the body, including the brain, spinal cord, testes, ovaries, and other organs. These tumors can be either benign (non-cancerous) or malignant (cancerous). The diagnosis of a Neoplasms, Germ Cell and Embryonal tumor typically involves a combination of imaging studies, such as CT scans or MRI scans, and a biopsy to examine the tissue. Treatment options may include surgery, chemotherapy, radiation therapy, or a combination of these approaches, depending on the type and location of the tumor, as well as the patient's overall health.

Endometrial neoplasms refer to abnormal growths or tumors that develop in the lining of the uterus, known as the endometrium. These neoplasms can be benign (non-cancerous) or malignant (cancerous). Endometrial neoplasms are classified based on their degree of malignancy, with the most common types being endometrial hyperplasia and endometrial cancer. Endometrial hyperplasia is a condition in which the cells in the endometrium grow abnormally, but do not invade into nearby tissues. Endometrial cancer, on the other hand, is a more serious condition in which the abnormal cells invade into nearby tissues and can spread to other parts of the body. Endometrial neoplasms can cause a variety of symptoms, including abnormal vaginal bleeding, pelvic pain, and pain during sexual intercourse. Diagnosis typically involves a combination of physical examination, imaging studies, and biopsy of the endometrial tissue. Treatment for endometrial neoplasms depends on the type, stage, and severity of the condition. Benign neoplasms may be treated with medication, surgery, or a combination of both. Malignant neoplasms may require more aggressive treatment, such as surgery, radiation therapy, or chemotherapy. Early detection and treatment are important for improving outcomes and reducing the risk of complications.

Urinary bladder neoplasms refer to abnormal growths or tumors that develop in the urinary bladder. These neoplasms can be either benign (non-cancerous) or malignant (cancerous). Benign neoplasms include cysts, polyps, and adenomas, while malignant neoplasms are classified as urothelial carcinomas, which are the most common type of bladder cancer. Symptoms of urinary bladder neoplasms may include blood in the urine, frequent urination, pain or burning during urination, and abdominal pain or discomfort. Diagnosis typically involves a combination of physical examination, imaging studies, and biopsy. Treatment options depend on the type, size, and stage of the neoplasm, and may include surgery, chemotherapy, radiation therapy, or a combination of these approaches.

Translocation, genetic refers to a type of chromosomal rearrangement in which a segment of one chromosome breaks off and attaches to a different chromosome or to a different part of the same chromosome. This can result in a variety of genetic disorders, depending on the specific genes that are affected by the translocation. Some examples of genetic disorders that can be caused by translocations include leukemia, lymphoma, and certain types of congenital heart defects. Translocations can be detected through genetic testing, such as karyotyping, and can be important for diagnosing and treating genetic disorders.

Lymphoma, T-cell is a type of cancer that affects the T-cells, which are a type of white blood cell that plays a crucial role in the immune system. T-cells are responsible for identifying and attacking foreign substances, such as viruses and bacteria, in the body. In T-cell lymphoma, the T-cells become abnormal and start to grow uncontrollably, forming tumors in the lymph nodes, spleen, and other parts of the body. There are several subtypes of T-cell lymphoma, including peripheral T-cell lymphoma,, and anaplastic large cell lymphoma. T-cell lymphoma can present with a variety of symptoms, including fever, night sweats, weight loss, fatigue, and swollen lymph nodes. Treatment options for T-cell lymphoma depend on the subtype and stage of the disease, and may include chemotherapy, radiation therapy, targeted therapy, and stem cell transplantation.

Leukemia, Lymphocytic, Chronic, B-Cell (CLL) is a type of cancer that affects the white blood cells, specifically the B-lymphocytes. It is a slow-growing cancer that typically progresses over a long period of time, and it is the most common type of leukemia in adults. In CLL, the affected B-lymphocytes do not mature properly and continue to multiply uncontrollably, leading to an overproduction of these cells in the bone marrow and bloodstream. This can cause a variety of symptoms, including fatigue, weakness, fever, night sweats, and swollen lymph nodes. Treatment for CLL typically involves a combination of chemotherapy, targeted therapy, and immunotherapy, and the specific approach will depend on the individual patient's age, overall health, and the stage and severity of their disease. Some patients may also be eligible for stem cell transplantation.

Nasopharyngeal neoplasms refer to tumors that develop in the nasopharynx, which is the part of the throat located at the back of the nose and the top of the throat. These tumors can be either benign or malignant, and they can occur in any part of the nasopharynx, including the nasopharyngeal epithelium, the lymphoid tissue, and the salivary glands. Nasopharyngeal neoplasms are relatively uncommon, but they can be aggressive and difficult to treat. Some of the most common types of nasopharyngeal neoplasms include nasopharyngeal carcinoma, which is a type of head and neck cancer that is particularly common in certain parts of the world, such as Southeast Asia and Southern China, and nasopharyngeal angiofibroma, which is a benign tumor that is more common in adolescent boys. The symptoms of nasopharyngeal neoplasms can vary depending on the location and size of the tumor, but they may include nasal congestion, difficulty swallowing, ear pain, hearing loss, and a persistent sore throat. Diagnosis typically involves a combination of physical examination, imaging studies, and biopsy. Treatment for nasopharyngeal neoplasms may include surgery, radiation therapy, chemotherapy, or a combination of these approaches. The choice of treatment depends on the type and stage of the tumor, as well as the overall health of the patient.

In the medical field, a coma is a state of prolonged unconsciousness in which a person is unresponsive to their environment and cannot be awakened. Comas can be caused by a variety of factors, including head injuries, brain infections, drug overdose, and certain medical conditions such as stroke or heart attack. During a coma, a person's brain activity is significantly reduced, and they may show little to no signs of awareness or responsiveness. They may also experience changes in their vital signs, such as a slower heart rate and lower blood pressure. The duration of a coma can vary widely, from a few hours to several weeks or even months. In some cases, a person may emerge from a coma with no lasting effects, while in other cases, they may experience permanent brain damage or disability. Treatment for a coma typically involves addressing the underlying cause and providing supportive care to help the person's body recover.

Pleural neoplasms refer to tumors that develop in the pleura, which is the thin layer of tissue that covers the lungs and lines the inside of the chest cavity. These tumors can be either benign (non-cancerous) or malignant (cancerous). There are two types of pleural neoplasms: primary pleural neoplasms and secondary pleural neoplasms. Primary pleural neoplasms are tumors that start in the pleura itself, while secondary pleural neoplasms are tumors that have spread to the pleura from another part of the body. Some common types of pleural neoplasms include mesothelioma, a type of cancer that is often associated with exposure to asbestos, and pleural effusion, which is the accumulation of fluid in the pleural space. Other types of pleural neoplasms include pleural fibroma, pleural sarcoma, and pleural mesothelioma. The diagnosis of pleural neoplasms typically involves a combination of imaging tests, such as chest X-rays, CT scans, and MRI scans, as well as a biopsy to confirm the presence of cancer cells. Treatment options for pleural neoplasms depend on the type and stage of the cancer, as well as the overall health of the patient.

Nuclear proteins are proteins that are found within the nucleus of a cell. The nucleus is the control center of the cell, where genetic material is stored and regulated. Nuclear proteins play a crucial role in many cellular processes, including DNA replication, transcription, and gene regulation. There are many different types of nuclear proteins, each with its own specific function. Some nuclear proteins are involved in the structure and organization of the nucleus itself, while others are involved in the regulation of gene expression. Nuclear proteins can also interact with other proteins, DNA, and RNA molecules to carry out their functions. In the medical field, nuclear proteins are often studied in the context of diseases such as cancer, where changes in the expression or function of nuclear proteins can contribute to the development and progression of the disease. Additionally, nuclear proteins are important targets for drug development, as they can be targeted to treat a variety of diseases.

Lymphoma is a type of cancer that affects the lymphatic system, which is a part of the immune system. It occurs when lymphocytes, a type of white blood cell, grow and divide uncontrollably, forming abnormal masses or tumors in the lymph nodes, spleen, bone marrow, or other parts of the body. There are two main types of lymphoma: Hodgkin lymphoma and non-Hodgkin lymphoma. Hodgkin lymphoma is a less common type of lymphoma that typically affects younger adults and has a better prognosis than non-Hodgkin lymphoma. Non-Hodgkin lymphoma is a more common type of lymphoma that can affect people of all ages and has a wide range of outcomes depending on the specific subtype and the stage of the disease. Symptoms of lymphoma can include swollen lymph nodes, fever, night sweats, weight loss, fatigue, and itching. Diagnosis typically involves a combination of physical examination, blood tests, imaging studies, and a biopsy of the affected tissue. Treatment for lymphoma depends on the subtype, stage, and overall health of the patient. It may include chemotherapy, radiation therapy, targeted therapy, immunotherapy, or a combination of these approaches. In some cases, a stem cell transplant may also be necessary.

Carcinoembryonic Antigen (CEA) is a protein that is produced by certain types of cancer cells, as well as by normal cells in the embryonic stage of development. It is a glycoprotein that is found in the blood and tissues of the body. In the medical field, CEA is often used as a tumor marker, which means that it can be measured in the blood to help diagnose and monitor certain types of cancer. CEA levels are typically higher in people with cancer than in people without cancer, although they can also be elevated in other conditions, such as inflammatory bowel disease, liver disease, and smoking. CEA is most commonly used as a tumor marker for colorectal cancer, but it can also be used to monitor the response to treatment and to detect recurrence of the cancer. It is also used as a tumor marker for other types of cancer, such as pancreatic cancer, breast cancer, and lung cancer. It is important to note that while elevated CEA levels can be a sign of cancer, they do not necessarily mean that a person has cancer. Other factors, such as age, gender, and family history, can also affect CEA levels. Therefore, CEA should be interpreted in conjunction with other diagnostic tests and clinical information.

Gastrointestinal neoplasms refer to tumors or abnormal growths that develop in the lining of the digestive tract, including the esophagus, stomach, small intestine, large intestine, rectum, and anus. These neoplasms can be either benign (non-cancerous) or malignant (cancerous). Gastrointestinal neoplasms can cause a variety of symptoms, depending on the location and size of the tumor. Some common symptoms include abdominal pain, changes in bowel habits, nausea and vomiting, weight loss, and anemia. Diagnosis of gastrointestinal neoplasms typically involves a combination of medical history, physical examination, imaging tests such as endoscopy or CT scans, and biopsy. Treatment options for gastrointestinal neoplasms depend on the type, size, and location of the tumor, as well as the overall health of the patient. Treatment may include surgery, chemotherapy, radiation therapy, or a combination of these approaches.

Lymphoma, B-Cell is a type of cancer that affects the B cells, which are a type of white blood cell that plays a crucial role in the immune system. B cells are responsible for producing antibodies that help the body fight off infections and diseases. In lymphoma, B cells grow and divide uncontrollably, forming tumors in the lymph nodes, bone marrow, and other parts of the body. There are several subtypes of B-cell lymphoma, including diffuse large B-cell lymphoma (DLBCL), follicular lymphoma, and chronic lymphocytic leukemia (CLL). The symptoms of B-cell lymphoma can vary depending on the subtype and the location of the tumors, but may include swollen lymph nodes, fatigue, fever, night sweats, and weight loss. Treatment for B-cell lymphoma typically involves a combination of chemotherapy, radiation therapy, and targeted therapies. The specific treatment plan will depend on the subtype of lymphoma, the stage of the disease, and the overall health of the patient. In some cases, a stem cell transplant may also be recommended.

Pregnancy complications, neoplastic refers to pregnancy-related complications that are caused by neoplasms, which are abnormal growths of cells. Neoplasms can be benign (non-cancerous) or malignant (cancerous). During pregnancy, neoplasms can cause a variety of complications, including: 1. Gestational trophoblastic disease: This is a group of rare tumors that develop from the placenta. It can cause bleeding, high blood pressure, and other complications. 2. Gestational choriocarcinoma: This is a rare type of cancer that develops from the placenta. It can spread quickly and cause high blood pressure, bleeding, and other complications. 3. Malignant melanoma: This is a type of skin cancer that can develop during pregnancy. It can spread quickly and cause complications for both the mother and the baby. 4. Breast cancer: While breast cancer is more common in non-pregnant women, it can also occur during pregnancy. It can cause complications for both the mother and the baby, including bleeding, infection, and the need for surgery. Treatment for pregnancy complications caused by neoplasms depends on the type and severity of the condition. It may include surgery, chemotherapy, radiation therapy, or a combination of these treatments. In some cases, it may be necessary to terminate the pregnancy to treat the neoplasm.

Cell transformation, neoplastic refers to the process by which normal cells in the body undergo genetic changes that cause them to become cancerous or malignant. This process involves the accumulation of mutations in genes that regulate cell growth, division, and death, leading to uncontrolled cell proliferation and the formation of tumors. Neoplastic transformation can occur in any type of cell in the body, and it can be caused by a variety of factors, including exposure to carcinogens, radiation, viruses, and inherited genetic mutations. Once a cell has undergone neoplastic transformation, it can continue to divide and grow uncontrollably, invading nearby tissues and spreading to other parts of the body through the bloodstream or lymphatic system. The diagnosis of neoplastic transformation typically involves a combination of clinical examination, imaging studies, and biopsy. Treatment options for neoplastic transformation depend on the type and stage of cancer, as well as the patient's overall health and preferences. Common treatments include surgery, radiation therapy, chemotherapy, targeted therapy, and immunotherapy.

Uterine cervical neoplasms refer to abnormal growths or tumors that develop in the cervix, which is the lower part of the uterus that connects to the vagina. These neoplasms can be either benign (non-cancerous) or malignant (cancerous). Cervical neoplasms can be classified into different types based on their characteristics and degree of malignancy. The most common type of cervical neoplasm is cervical intraepithelial neoplasia (CIN), which is a precancerous condition that can progress to invasive cervical cancer if left untreated. Cervical cancer is a serious health concern worldwide, and it is the fourth most common cancer in women globally. However, with regular screening and appropriate treatment, the prognosis for cervical cancer is generally good when it is detected early.

Ventricular dysfunction, left, is a medical condition in which the left ventricle of the heart is unable to pump blood efficiently. The left ventricle is responsible for pumping oxygen-rich blood from the heart to the rest of the body. When it is not functioning properly, it can lead to a variety of symptoms, including shortness of breath, fatigue, and chest pain. There are several causes of left ventricular dysfunction, including heart attacks, high blood pressure, coronary artery disease, and heart valve problems. Treatment for left ventricular dysfunction depends on the underlying cause and may include medications, lifestyle changes, and in some cases, surgery. Left ventricular dysfunction can be a serious condition and requires prompt medical attention.

Carcinoma, Signet Ring Cell is a type of cancer that originates in the cells of the stomach lining. It is characterized by the presence of cells with a distinctive appearance, called signet ring cells, which have a large central nucleus surrounded by a clear, eosinophilic cytoplasm that stains pink. These cells are thought to be derived from glandular cells in the stomach lining and are often associated with the production of excess acid by the stomach. Carcinoma, Signet Ring Cell is a relatively rare type of stomach cancer, accounting for less than 1% of all cases. It is typically diagnosed at an advanced stage and has a poor prognosis, with a high risk of recurrence and metastasis. Treatment options for Carcinoma, Signet Ring Cell may include surgery, chemotherapy, radiation therapy, and targeted therapy.

RNA, Small Interfering (siRNA) is a type of non-coding RNA molecule that plays a role in gene regulation. siRNA is approximately 21-25 nucleotides in length and is derived from double-stranded RNA (dsRNA) molecules. In the medical field, siRNA is used as a tool for gene silencing, which involves inhibiting the expression of specific genes. This is achieved by introducing siRNA molecules that are complementary to the target mRNA sequence, leading to the degradation of the mRNA and subsequent inhibition of protein synthesis. siRNA has potential applications in the treatment of various diseases, including cancer, viral infections, and genetic disorders. It is also used in research to study gene function and regulation. However, the use of siRNA in medicine is still in its early stages, and there are several challenges that need to be addressed before it can be widely used in clinical practice.

Vascular Endothelial Growth Factor A (VEGF-A) is a protein that plays a crucial role in the growth and development of blood vessels. It is produced by a variety of cells, including endothelial cells, fibroblasts, and smooth muscle cells, and is involved in a number of physiological processes, including wound healing, angiogenesis (the formation of new blood vessels), and tumor growth. VEGF-A binds to receptors on the surface of endothelial cells, triggering a signaling cascade that leads to the proliferation and migration of these cells, as well as the production of new blood vessels. This process is essential for the growth and development of tissues, but it can also contribute to the formation of tumors and other pathological conditions. In the medical field, VEGF-A is often targeted as a potential therapeutic agent for a variety of diseases, including cancer, cardiovascular disease, and eye disorders. Anti-VEGF-A therapies, such as monoclonal antibodies and small molecule inhibitors, are used to block the activity of VEGF-A and its receptors, thereby inhibiting angiogenesis and tumor growth.

Hodgkin disease, also known as Hodgkin lymphoma, is a type of cancer that affects the lymphatic system, which is a part of the immune system. It typically starts in the lymph nodes, which are small, bean-shaped organs that help fight infections and diseases. In Hodgkin disease, abnormal cells called Reed-Sternberg cells grow and multiply uncontrollably in the lymph nodes, causing them to become swollen and painful. The cancer can also spread to other parts of the body, such as the spleen, liver, and bone marrow. There are several different types of Hodgkin disease, which are classified based on the appearance of the Reed-Sternberg cells and the presence of other cells in the affected lymph nodes. Treatment for Hodgkin disease typically involves a combination of chemotherapy, radiation therapy, and/or stem cell transplantation, depending on the stage and type of the cancer.

Look up prognosis in Wiktionary, the free dictionary. Computer models at prognosis.org (Articles with short description, Short ... Prognosis (Greek: πρόγνωσις "fore-knowing, foreseeing"; PL: prognoses) is a medical term for predicting the likelihood or ... Gould, SJ, The Median Isn't the Message, retrieved 1 November 2014 "Multiple Myeloma Prognosis". Multiple Myeloma Prognosis. ... Knowing the prognosis helps determine whether it makes more sense to attempt certain treatments or to withhold them, and thus ...
A panel of epigenetic methylation marker has been explored for prognosis of ovarian cancer, and it is reported that the panel ... Understanding the Molecular Basis of Histologic Grade To Improve Prognosis". Journal of the National Cancer Institute. 98 (4): ... and observation of metastasis often associate with poor prognosis. In recent years, advances in molecular techniques, genomics ... cancer biology and sequencing technology have provided opportunities to discover and validate new biomarkers for prognosis, ...
Prognosis is a doctor's prediction about a disease. Prognosis may also refer to: Prediction, a statement or claim that a ... Look up prognosis, prognosticate, or prognostication in Wiktionary, the free dictionary. ... ascertaining information from supernatural sources This disambiguation page lists articles associated with the title Prognosis ...
The prognosis of schizophrenia is varied at the individual level. In general it has great human and economics costs. It results ... Cohen A, Patel V, Thara R, Gureje O (March 2008). "Questioning an axiom: better prognosis for schizophrenia in the developing ... Several factors are associated with a better prognosis: female gender, acute (vs. insidious) onset of symptoms, older age of ... Several factors have been associated with a better overall prognosis: Being female, rapid (vs. insidious) onset of symptoms, ...
There is currently no evidence of a cure for autism. The degree of symptoms can decrease, occasionally to the extent that people lose their diagnosis of ASD; this occurs sometimes after intensive treatment and sometimes not. It is not known how often this outcome happens, with reported rates in unselected samples ranging from 3% to 25%. Although core difficulties tend to persist, symptoms often become less severe with age. Acquiring language before age six, having an IQ above 50, and having a marketable skill all predict better outcomes; independent living is unlikely in autistic people with higher support needs. There are two possible developmental courses of ASD. One course of development is more gradual in nature, with symptoms appearing fairly early in life and persisting. A second course of development is characterized by normal or near-normal development before onset of regression or loss of skills, which is known as regressive autism. Most parents report that the onset of autism features ...
"Prognosis". www.goodreads.com. Retrieved 2020-11-19. Media, Arizona Public. "Coming In Hot". www.azpm.org. Retrieved 2020-11-19 ... Prognosis: A Memoir of My Brain by Sarah Vallance, Little A 2019). Powder was adapted for the stage under the title Coming in ...
Prognosis. "Entry: Mahl Dynasty - Borderline". Retrieved 2008-01-04.[dead link] John Shannon. "Review: ProgDay Kinections ...
Prognosis. Bloomberg L.P. Archived from the original on 2020-03-26. Retrieved 2020-03-26. Grimes, David (1991-11-20). "Goodbye ...
Prognosis". Scott Med J. 2 (5): 200-15. doi:10.1177/003693305700200504. PMID 13432835. S2CID 29669359. van Swieten, J C; ...
Prognosis (Greek: πρόγνωσις "fore-knowing, foreseeing"; PL: prognoses) is a medical term for predicting the likelihood or ... "What is the prognosis of a genetic condition?". Genetics Home Reference. NIH: U.S. National Library of Medicine. Retrieved 2018 ... A complete prognosis includes the expected duration, function, and description of the course of the disease, such as ... "Prognosis". Nature Publishing Group. Retrieved 20 May 2018. Gould, SJ, The Median Isn't the Message, retrieved 1 November 2014 ...
Information on the prognosis of CFS is limited, and the course of the illness is variable. According to the NICE guideline, CFS ... A systematic review found that fatigue severity was the main predictor of prognosis in CFS, and did not identify psychological ... The National Academy of Medicine report says it is a misconception that diagnosing ME/CFS worsens prognosis, and that accurate ... Another review found that children have a better prognosis than adults, with 54-94% having recovered by follow-up, compared to ...
ISBN 0-7388-4424-1. Prognosis. "Entry: Nathan Mahl". Retrieved January 4, 2008.[dead link] Bob Eichler. "Review: Mahl Dynasty ...
s r.o. = Ltd.). In July 1991, Lisa Frankenberg (now Lisa Leshne) and Kent Hawryluk, two employees of Prognosis, an English- ... Prognosis 1991-1995 and Prague Pill 2001-2003 -the Prague Post was the longest running English-language newspaper in the Czech ... "Matt Welch , Prognosis". http://www.mattwelch.com. Retrieved 20 March 2011. "Special Report - Dynamic Women in Business 2001- ...
Prognosis.ru. 6 January 2004. Archived from the original on 4 March 2016. Retrieved 16 December 2016. "Абхазия: тернистый путь ...
Prognosis". Epocrates. Archived from the original on 5 December 2021. Retrieved 31 May 2022. Thiel, Jens; Kimmig, Lucas; Salzer ...
The prognosis is poor in large animals that are recumbent. In cattle, the symptoms may include drooling, restlessness, ... "Botulism Prognosis". Medical Life Sciences. 2 December 2009. Archived from the original on 9 February 2019. Retrieved 8 ...
Baillie K. "Arterial Blood Gas Interpreter". prognosis.org. Retrieved 2007-07-05. - Online arterial blood gas analysis Baillie ...
Patients with SJS or TEN caused by a drug have a better prognosis the earlier the causative drug is withdrawn. SJS is a rare ... 2013, Prognosis. Shanbhag, Swapna S.; Sangwan, Virender S.; Singh, Aastha; Donthineni, Pragnya R.; Basu, Sayan; Srinivasan, ...
See Prognosis.) The exact length of time between infection and symptoms is unclear. A review of the literature made an estimate ...
Prognosis.ru. June 13, 2006. Retrieved October 25, 2007 Swietochowski, Tadeusz , "Russian Azerbaijan, 1905-1920:The Shaping of ...
Prolonged submersion in water for more than 5-10 minutes usually leads to poorer prognosis. Data on the long-term outcome are ... As this distinction does not change management or prognosis but causes significant confusion due to alternate definitions and ... Cantwell, G Patricia (5 July 2016). "Drowning: Prognosis". Drugs & Diseases - Emergency Medicine. Medscape. Archived from the ...
"Prognosis Unclear". HuffPost. 10 August 2012. Retrieved 2016-01-07. Alonso-Zaldivar, Ricardo (9 December 2016). "'Protect Our ...
"Prognosis Profits". Charlotteobserver.com. "Letter from Charles E. Grassley, U.S. Senator, to Michael C. Tarwater, CEO, ...
"Dysentery-Prognosis". Archived from the original on 14 July 2011. Retrieved 17 November 2010. Byrne JP (2008). Encyclopedia of ... If the disease is left untreated, the prognosis varies with the immune status of the individual patient and the severity of ...
Prognosis: poor. Diagnosing Doctor:Misao Kusuda. She was born to a rich man in Yamato-Takaichi-gun, and possessed land. She ...
"Prognosis Negative". The Ecphorizer, Issue 28, December 1983. "The Miracle of Pennsylvania Avenue". The Ecphorizer, Issue 29, ...
Prognosis bleak. [...] Will have to get used to the idea of losing the good animal. Fed him sausage in the heater where he ...
". "ACA Prognosis". 6 December 2013. "The Inevitability of Health Reform". "Docs Await ACA Compliance Rules Interview". 30 May ...
... documenting and explaining how physicians are socialized to avoid making prognoses. It argues that the prognoses patients ... P. Glare and N.A. Christakis, eds., Prognosis in Advanced Cancer, Oxford University Press, 2008 ISBN 978-0-19-853022-0 G. Hanks ... Gina Kolata, "A Conversation with: Nicholas Christakis; A Doctor with a Cause: 'What's My Prognosis?'", The New York Times, ... Christakis' first book, Death Foretold: Prophecy and Prognosis in Medical Care, was published by the University of Chicago ...
"Privacy's Guarded Prognosis". The New York Times. 1 March 2001. Lohr, Steve (6 October 2009). "A Web Site Devoted to Your ...
Your health care provider bases your prognosis on the type and stage of cancer you have, your treatment, and ... Your prognosis is an estimate of how your cancer will progress and your chance of recovery. ... Understanding cancer prognosis. www.cancer.gov/cancertopics/factsheet/Support/prognosis-stats. Updated June 17, 2019. Accessed ... Your prognosis is an estimate of how your cancer will progress and your chance of recovery. Your health care provider bases ...
Cite this: Brain Metabolites Predict Severity, Prognosis of TBI - Medscape - Oct 24, 2014. ... and may serve as predictors of prognosis, Finnish investigators report. ...
Prognosis. The prognosis for patients with uncomplicated lymphangitis is good. Antimicrobial regimens are effective in more ... Bacteria can grow rapidly in the lymphatic system (see the image below). (See Etiology and Prognosis.) ...
Prognosis and Determinants of Asthma Morbidity in World Trade Center Rescue and Recovery Workers will provide a detailed ... Prognosis and Determinants of Asthma Morbidity in WTC Rescue and Recovery Workers. ...
Long-Term Prognosis for Clinical West Nile Virus Infection Anne Labowitz Klee*, Beth Maldin*, Barbara Edwin*, Iqbal Poshni*, ... Long-Term Prognosis for Clinical West Nile Virus Infection. ...
Prognosis Laboratories offers services including molecular diagnostics, clinical pathology, hematology, microbiology, serology ... Prognosis Laboratories, based in Delhi, offers a variety of services, including molecular diagnostics, clinical pathology, ... "The state-of-the-art facility of Prognosis Laboratory and our expertise in genomics and personalized medicine will help us ... NEW YORK - MedGenome said last week that it has acquired Indian diagnostics company Prognosis Laboratories for an undisclosed ...
... providing an update on his prognosis since being diagnosed with cancer back in June. ... Former Red Wings announcer Dave Strader released a statement Wednesday, providing an update on his prognosis since being ...
... and histological features and the response to steroid treatment have been correlated with the prognosis. An early objective ...
Consorts prognosis is for few surprises in its results. SMALL BUT BEAUTIFUL ...
Prognosis. Persons who are homozygous for alpha2-plasmin inhibitor (alpha2-PI) deficiency have a severe bleeding disorder, but ...
Cheng, Z., Dai, Y., Pang, Y. et al. Enhanced expressions of FHL2 and iASPP predict poor prognosis in acute myeloid leukemia. ... Enhanced expressions of FHL2 and iASPP predict poor prognosis in acute myeloid leukemia. *Zhiheng Cheng ORCID: orcid.org/0000- ...
Noncommunicable disease, clinical course and COVID-19 prognosis: results based on I-CORE Registry ... The current study presents an overview of comorbid NCDs and prognosis in hospitalized patients with COVID-19 in Isfahan ... Noncommunicable disease, clinical course and COVID-19 prognosis: results based on I-CORE Registry. East Mediterr Health J. 2021 ... A strong association between NCDs and some clinical characteristics may affect COVID-19 prognosis and cause disappearance of ...
RDW was found to be such an important indicator of prognosis that mesothelioma patients with levels higher than 20% had a 2.77- ... Inflammatory Markers May Predict Mesothelioma Prognosis. ByAlex Strauss February 28, 2014. May 23, 2019. ... Abakay, O, "The value of inflammatory parameters in the prognosis of malignant mesothelioma", February 26, 2014, Journal of ... ratio and the red cell distribution width were significant predictive factors for malignant mesothelioma prognosis." Prognostic ...
talk contribs‎ 6,060 bytes −1‎ →‎Prognosis. *curprev. 04:0604:06, 14 December 2017‎ Dildar Hussain. talk contribs‎ 6,061 bytes ... talk contribs‎ 6,060 bytes −1‎ →‎Prognosis. *curprev. 04:0404:04, 14 December 2017‎ Dildar Hussain. talk contribs‎ 6,061 bytes ... talk contribs‎ 5,722 bytes −7‎ →‎Prognosis Tag: Visual edit. *curprev. 17:3617:36, 11 December 2017‎ Dildar Hussain. talk ... talk contribs‎ 5,759 bytes +4‎ →‎Prognosis Tag: Visual edit. *curprev. 17:3417:34, 11 December 2017‎ Dildar Hussain. talk ...
Kaplan Meier curves show that those with hsTnT levels above the cutoff point presented a worse prognosis (log-rank test, 𝑃. =. ... High-Sensitivity Troponin T and Copeptin in Non-ST Acute Coronary Syndromes: Implications for Prognosis and Role of hsTnT and ... Our study has the important limitation of the measurement of single baseline samples in determining prognosis. Although hsTnT ... might help to the better stratification and managements as well as in the prognosis of patients with non-STEACS. ...
Wary private White House coronavirus prognoses in February tipped off certain investors to the coming crash. ...
Lately, we here at WFME are a little concerned that the couch fort has fallen to the wayside and been replaced by things like "video games" and "cheese." Children are more intrigued by the flashing epileptic seizure-esque images on their television screens and huge blocks of cheese…instead of fashioning a huge defense station out of cushy couch cushions. Today, children would rather jack cars and make grilled-cheese sandwiches instead of hiding from their fellow family members in a dark, musty, cat-hair covered secret lair. Today, children of the world would rather play their Nintendo DSes and digest palatable gouda instead of protecting themselves from the evil aliens of the universe while hidden deep inside a Pottery Barn barracade. ...
Epidemioclinics, Etiologies and Prognosis of Cardiogene Shock State in the Intensive Care Unit of the Cardiology Department of ... Conclusion: Cardiogenic shock is an infrequent condition with a high mortality of a prognosis. Ischemic heart disease is the ... Cardiogenic shock is an infrequent condition with a high mortality of a prognosis. Ischemic heart disease is the most common ... Baptiste, S.J. (2011) Prognosis and Management of Non-Ischemic Cardiogenic Shock. Medicine Thesis, University of Henri Poincare ...
Prognosis. As mentioned above, corticobasal degeneration is a progressive disease, hence, both the cognitive as well as the ...
Prognosis of 980 patients with gastric cancer after surgical resection. Chinese journal of cancer. 2010Nov;29(11):923-30 PubMed ... Low Expression of CDK10 Correlates with Adverse Prognosis in Gastric Carcinoma Bai-wei Zhao1, 2#, Shi Chen1,3#, Yuan-Fang Li1, ... Low Expression of CDK10 Correlates with Adverse Prognosis in Gastric Carcinoma. J Cancer 2017; 8(15):2907-2914. doi:10.7150/jca ... Low Expression of CDK10 Correlates with Adverse Prognosis in Gastric Carcinoma. J Cancer 2017; 8(15):2907-2914. doi:10.7150/jca ...
Thr164Ile polymorphism of β2-adrenergic receptor negatively modulates cardiac contractility: implications for prognosis in ... Thr164Ile polymorphism of β2-adrenergic receptor negatively modulates cardiac contractility: implications for prognosis in ... Thr164Ile polymorphism of β2-adrenergic receptor negatively modulates cardiac contractility: implications for prognosis in ...
The prognosis in infancy is thought to be poor2-4; a recent case series2 recorded nine deaths out of ten patients. The authors ... Despite previous reports of a poor prognosis in this age group,2-4 ,9 all our patients are alive at a median age of 6 years. ... In contrast to previous reports,2 ,9 we did not find that a young age of presentation resulted in a worse prognosis. ... This striking difference in prognosis in this series could be a reflection of the heterogeneous nature of the condition, with ...
The Prog-nosis // April 2021. The Prog-nosis Aversed Beyond Creation Dvne Genghis Tron Ghostbound gorod Ne Obliviscaris Opeth ...
Tag: Favorable Prognosis. Posted on February 13, 2009. June 20, 2011. A Very Narrow Line. What does a physician tell a newly ... They want to play a no-lose game! If they are correct, and generally a patient will fulfill the physicians prognosis, they were ...
... Signa Vitae. 2021. 17(5);18-29. ... Thirty-four articles were included in the review, and relevant data were extracted from the risk prognosis model. ... This systematic review compared different types of models for predicting the prognosis of influenza infection, informing us of ... Early recognition of potentially terrible outcomes is important in the emergency department (ED). Efficient prognosis of the ...
Psoas muscle index at the time of diagnosis might reflect the prognosis of classical Hodgkinʼs lymphoma patients. verfasst von ... Psoas muscle index at the time of diagnosis might reflect the prognosis of classical Hodgkinʼs lymphoma patients ... Psoas muscle index at the time of diagnosis might reflect the prognosis of classical Hodgkinʼs lymphoma patients , ...
Europe, United States, adult, aged, article, cancer chemotherapy, cancer patient, cancer prognosis, cancer staging, cancer ... Three-gene immunohistochemical panel adds to clinical staging algorithms to predict prognosis for patients with esophageal ... no molecular biomarkers are currently used in routine clinical practice to determine prognosis or aid clinical decision making ... Three-gene immunohistochemical panel adds to clinical staging algorithms to predict prognosis for patients with esophageal ...
Error in prognosis dealer agreement (or franchise agreement). By mr. A.W. DolphijnPublished On: 06-01-2015Categories: ... There does not seem to be any such prognosis here to be. It is also questionable whether this concerns a (different) provision ...
2015). Early prognosis of noise-induced hearing loss: Prioritizing prevention over prediction. 72(2). Themann, Christa L. et al ... "Early prognosis of noise-induced hearing loss: Prioritizing prevention over prediction" 72, no. 2 (2015). Themann, Christa L. ... "Early prognosis of noise-induced hearing loss: Prioritizing prevention over prediction" vol. 72, no. 2, 2015. Export RIS ... Title : Early prognosis of noise-induced hearing loss: Prioritizing prevention over prediction Personal Author(s) : Themann, ...
Prognosis and complications. In the most recent five years, the mortality rate of necrotizing fasciitis ranges from 11% to 22%. ...
  • BACKGROUND Pulmonary interstitial fibrosis in children is a disease of unknown aetiology, usually associated with a poor prognosis. (bmj.com)
  • Analysis of the Long-Term Prognosis in Japanese Patients with Ulcerative Colitis Treated with New Therapeutic Agents and the Correlation between Prognosis and Disease Susceptibility Loci. (bvsalud.org)
  • This study evaluates long-term prognosis in Japanese patients treated with these agents and the association between prognosis and genetic susceptibility to UC. (bvsalud.org)
  • The rate of use of new therapeutic agents was compared using the Kaplan-Meier method , and multivariate analysis was conducted to investigate the correlation between the single- nucleotide polymorphism (SNP) rs117506082 and long-term prognosis . (bvsalud.org)
  • The use of new therapeutic agents might improve long-term prognosis in patients with more severe UC. (bvsalud.org)
  • BOSTON - Serum levels of several common metabolites appear to be good biomarkers for estimating the severity of traumatic brain injury (TBI) and may serve as predictors of prognosis, Finnish investigators report. (medscape.com)
  • RDW was found to be such an important indicator of prognosis that mesothelioma patients with levels higher than 20% had a 2.77-fold increase in mortality. (survivingmesothelioma.com)
  • To determine noncommunicable disease (NCD), clinical characteristics and prognosis of patients hospitalized with COVID-19 in Isfahan, Islamic Republic of Iran. (who.int)
  • Our data suggest that reduced CDK10 expression independently predicts a poor prognosis in patients with gastric cancer. (jcancer.org)
  • CONCLUSION The good prognosis seen in these patients is different to previous case reports, indicating a greater than 50% mortality. (bmj.com)
  • Early recognition of potentially terrible outcomes is important in the emergency department (ED). Efficient prognosis of the disease is conducive to reducing the financial burden and providing appropriate care for patients. (signavitae.com)
  • Are the worse outcomes here due to 'inadequate treatment' (in which case patients would indeed benefit from more aggressive/long-lasting rehab) or is loss of function/failure to regain function within a month more of a marker of illness/frailty/something else underlying the poorer prognosis which won't necessarily improve with rehab? (pallimed.org)
  • The prognosis for patients with uncomplicated lymphangitis is good. (medscape.com)
  • Context and objective In intensive care units (ICU), clinicians have little information to identify COVID-19 patients at high risk of poor prognosis requiring intubation . (bvsalud.org)
  • Cardiogenic shock is an infrequent condition with a high mortality of a prognosis. (scirp.org)
  • Prognosis and Determinants of Asthma Morbidity in World Trade Center Rescue and Recovery Workers' will provide a detailed assessment of the clinical presentation, relationship with exposure, treatment needs, evaluation of the influence of comorbidities on disease presentation, and the impact of asthma on the quality of life of WTC workers. (cdc.gov)
  • The clinical, radiographic, physiological, and histological features and the response to steroid treatment have been correlated with the prognosis. (bmj.com)
  • Despite growing knowledge of its biology, no molecular biomarkers are currently used in routine clinical practice to determine prognosis or aid clinical decision making. (eur.nl)
  • In an article in the Journal of International Medical Research, the authors concluded, "The neutrophil-to-lymphocyte ratio and the red cell distribution width were significant predictive factors for malignant mesothelioma prognosis. (survivingmesothelioma.com)
  • This systematic review compared different types of models for predicting the prognosis of influenza infection, informing us of risk factors for the predictive model in predicting the prognosis of influenza in the early stage. (signavitae.com)
  • METHODS In this case series we describe 11 children presenting over a 10 year period, managed conservatively and associated with a good prognosis. (bmj.com)
  • Title : Early prognosis of noise-induced hearing loss: Prioritizing prevention over prediction Personal Author(s) : Themann, Christa L.;Byrne, David C.;Davis, Rickie R.;Morata, Thais C.;Murphy, William J.;Stephenson, Mark R. (cdc.gov)
  • Medical Xpress) -- Scientists from the Friedrich Miescher Institute for Biomedical Research describe how the protein phosphatase SHP2 promotes breast cancer with poor prognosis. (medicalxpress.com)
  • These genes are activated in a large subset of primary breast tumors associated with invasive behavior and poor prognosis . (medicalxpress.com)
  • The authors suggested that a delay in diagnosis might have contributed to the poor prognosis. (bmj.com)
  • 500, the prognosis is poor. (cdc.gov)
  • Classification of neck/shoulder pain in epidemiological research: a comparison of personal and occupational characteristics, disability and prognosis among 12,195 workers from 18 countries. (cdc.gov)
  • Your health care provider bases your prognosis on the type and stage of cancer you have, your treatment , and what has happened to people with cancer similar to yours. (medlineplus.gov)
  • Early identification of VHL is important because of the increased risk of serious complications (eg, renal cell carcinoma) to foster more effective treatment options and better prognoses. (medscape.com)
  • Treatment and prognosis for intermediate syndrome. (cdc.gov)
  • To inform case-definition for neck/shoulder pain in epidemiological research, we compared levels of disability, patterns of association and prognosis for pain that was limited to the neck or shoulders (LNSP) and more generalised musculoskeletal pain that involved the neck or shoulder(s) (GPNS). (cdc.gov)
  • Prognosis of surgical disease / [edited by] Ben Eiseman. (who.int)
  • Many factors affect your prognosis. (medlineplus.gov)
  • Were identified variables that could affect motor prognosis in children with cerebral palsy. (bvsalud.org)
  • Your prognosis is an estimate of how your cancer will progress and your chance of recovery. (medlineplus.gov)
  • Former Red Wings announcer Dave Strader released a statement Wednesday, providing an update on his prognosis since being diagnosed with cancer back in June. (wxyz.com)
  • Lifetime prognosis after birth. (who.int)
  • Introduction: Emergency physicians (EPs) are reported to have a higher rate of substance use disorder (SUD) than most specialties, although little is known about their prognosis. (escholarship.org)
  • using the Medline and LILACS, data bases searching for the last fifteen years with the terms cerebral palsy, quadriplegia, diplegia, hemiplegia, prognosis. (bvsalud.org)
  • So remember that when you receive a prognosis, it is not set in stone. (medlineplus.gov)
  • Diagnosis and prognosis -- the ability to state what was wrong with the patient and to predict the course of the ailment -- were of primary importance to medieval physicians. (nih.gov)
  • Most diagnosis and prognosis of internal conditions displaying no overt symptoms were based upon the examination of urine or feeling the pulse of the patient, though other methods were employed as well, including astrology and other divinatory techniques. (nih.gov)
  • The topics of diagnosis and prognosis formed a part of every medieval medical encyclopaedia. (nih.gov)
  • This funding opportunity announcement (FOA) encourages Research Project Grant (R01) applications that propose to develop and validate new mitochondrial-related biomarkers for cancer early detection, diagnosis, prognosis, risk assessment, and response to preventive and ameliorative treatments. (nih.gov)
  • Your prognosis is an estimate of how your cancer will progress and your chance of recovery. (medlineplus.gov)
  • Prognosis is the estimate that the physician makes of the progression of the disease in each particular case and how it will respond to treatment. (survivornet.ca)
  • The relationship between the degree of myocardial and pericardial involvement on patient prognosis is not well characterized in the literature. (medscape.com)
  • The new NEA Expert Group on Comparison and Understanding of Dose Prognosis (EGDP) held its kick‑off meeting remotely on 24 March 2020. (oecd-nea.org)
  • if the cancer has spread to the skull, it usually indicates a poor prognosis. (survivornet.ca)
  • myADLM.org // Science & Research // Scientific Shorts // Is a single-tube multimarker assay a perspective test in improving the prognoses of preeclampsia? (aacc.org)
  • When the same research samples were assessed in parallel using the sFlt-1/PlGF based test (Thermo Fischer Scientific, Hennigsdorf, Germany), correct PE prognosis was reached for only 73.7% of the analyzed pregnancy cases (AUC 0.87). (aacc.org)
  • The group's working methodology is based on an exercise, in which member countries will use the same agreed‑upon source term for a given accident site, run their own dose prognosis code, and compare their results. (oecd-nea.org)
  • Based on their analysis, the genetic signature could help determine the 10-year prognosis for women who had already been diagnosed high-risk breast cancer. (nih.gov)
  • Diabetes is a risk factor for the progression and prognosis of COVID-19. (qxmd.com)
  • To figure out whether diabetes is a risk factor influencing the progression and prognosis of 2019 novel coronavirus disease (COVID-19). (qxmd.com)
  • Our data support the notion that diabetes should be considered as a risk factor for a rapid progression and bad prognosis of COVID-19. (qxmd.com)
  • people 60 years or older have a poorer prognosis. (survivornet.ca)
  • people who have associated health issues such as heart or lung disease might also have a poorer prognosis. (survivornet.ca)
  • The kick‑off meeting participants reviewed the group's programme of work, exchanged information on the dose prognosis codes used in member countries, and discussed the development of the EGDP exercise programme. (oecd-nea.org)
  • CHICAGO - While the Celtics were relieved that Marcus Smart has been diagnosed with nothing more than a left ankle sprain and a bone bruise, coach Brad Stevens warned Saturday that the 2-3-week prognosis for recovery is "hopeful. (bostonglobe.com)