The use of two or more chemicals simultaneously or sequentially in the drug therapy of neoplasms. The drugs need not be in the same dosage form.
Errors or mistakes committed by health professionals which result in harm to the patient. They include errors in diagnosis (DIAGNOSTIC ERRORS), errors in the administration of drugs and other medications (MEDICATION ERRORS), errors in the performance of surgical procedures, in the use of other types of therapy, in the use of equipment, and in the interpretation of laboratory findings. Medical errors are differentiated from MALPRACTICE in that the former are regarded as honest mistakes or accidents while the latter is the result of negligence, reprehensible ignorance, or criminal intent.
Incorrect diagnoses after clinical examination or technical diagnostic procedures.
Drug therapy given to augment or stimulate some other form of treatment such as surgery or radiation therapy. Adjuvant chemotherapy is commonly used in the therapy of cancer and can be administered before or after the primary treatment.
An organized procedure carried out by a select committee of professionals in evaluating the performance of other professionals in meeting the standards of their specialty. Review by peers is used by editors in the evaluation of articles and other papers submitted for publication. Peer review is used also in the evaluation of grant applications. It is applied also in evaluating the quality of health care provided to patients.
Substances that inhibit or prevent the proliferation of NEOPLASMS.
An inorganic and water-soluble platinum complex. After undergoing hydrolysis, it reacts with DNA to produce both intra and interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity of cisplatin correlates with cellular arrest in the G2 phase of the cell cycle.
A competitive serotonin type 3 receptor antagonist. It is effective in the treatment of nausea and vomiting caused by cytotoxic chemotherapy drugs, including cisplatin, and has reported anxiolytic and neuroleptic properties.
Pharmacologic agents in the form of a mist or spray delivered into the body through the mouth.
Process that is gone through in order for a drug to receive approval by a government regulatory agency. This includes any required pre-clinical or clinical testing, review, submission, and evaluation of the applications and test results, and post-marketing surveillance of the drug.
An agency of the PUBLIC HEALTH SERVICE concerned with the overall planning, promoting, and administering of programs pertaining to maintaining standards of quality of foods, drugs, therapeutic devices, etc.
Works about pre-planned studies of the safety, efficacy, or optimum dosage schedule (if appropriate) of one or more diagnostic, therapeutic, or prophylactic drugs, devices, or techniques selected according to predetermined criteria of eligibility and observed for predefined evidence of favorable and unfavorable effects. This concept includes clinical trials conducted both in the U.S. and in other countries.
Drugs used to prevent NAUSEA or VOMITING.
The forcible expulsion of the contents of the STOMACH through the MOUTH.
The interactions between physician and patient.
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
The treatment of a disease or condition by several different means simultaneously or sequentially. Chemoimmunotherapy, RADIOIMMUNOTHERAPY, chemoradiotherapy, cryochemotherapy, and SALVAGE THERAPY are seen most frequently, but their combinations with each other and surgery are also used.
The psychiatric, sociological and psychological study and treatment of the developing child with emphasis on preventive or prophylactic measures focused on the familial, educational and socio-environmental milieu of the child.
The muscle tissue of the HEART. It is composed of striated, involuntary muscle cells (MYOCYTES, CARDIAC) connected to form the contractile pump to generate blood flow.
Studies in which variables relating to an individual or group of individuals are assessed over a period of time.
Non-invasive method of demonstrating internal anatomy based on the principle that atomic nuclei in a strong magnetic field absorb pulses of radiofrequency energy and emit them as radiowaves which can be reconstructed into computerized images. The concept includes proton spin tomographic techniques.
The hollow, muscular organ that maintains the circulation of the blood.
Procedures that avoid use of open, invasive surgery in favor of closed or local surgery. These generally involve use of laparoscopic devices and remote-control manipulation of instruments with indirect observation of the surgical field through an endoscope or similar device.
A method of hemostasis utilizing various agents such as Gelfoam, silastic, metal, glass, or plastic pellets, autologous clot, fat, and muscle as emboli. It has been used in the treatment of spinal cord and INTRACRANIAL ARTERIOVENOUS MALFORMATIONS, renal arteriovenous fistulas, gastrointestinal bleeding, epistaxis, hypersplenism, certain highly vascular tumors, traumatic rupture of blood vessels, and control of operative hemorrhage.
Subspecialty of radiology that combines organ system radiography, catheter techniques and sectional imaging.
Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)
A method of delineating blood vessels by subtracting a tissue background image from an image of tissue plus intravascular contrast material that attenuates the X-ray photons. The background image is determined from a digitized image taken a few moments before injection of the contrast material. The resulting angiogram is a high-contrast image of the vessel. This subtraction technique allows extraction of a high-intensity signal from the superimposed background information. The image is thus the result of the differential absorption of X-rays by different tissues.
A short thick vein formed by union of the superior mesenteric vein and the splenic vein.
Diagnostic and therapeutic procedures that are invasive or surgical in nature, and require the expertise of a specially trained radiologist. In general, they are more invasive than diagnostic imaging but less invasive than major surgery. They often involve catheterization, fluoroscopy, or computed tomography. Some examples include percutaneous transhepatic cholangiography, percutaneous transthoracic biopsy, balloon angioplasty, and arterial embolization.
A heterogeneous aggregate of at least three distinct histological types of lung cancer, including SQUAMOUS CELL CARCINOMA; ADENOCARCINOMA; and LARGE CELL CARCINOMA. They are dealt with collectively because of their shared treatment strategy.
Tumors or cancer of the LUNG.
The reconstruction of a continuous two-stranded DNA molecule without mismatch from a molecule which contained damaged regions. The major repair mechanisms are excision repair, in which defective regions in one strand are excised and resynthesized using the complementary base pairing information in the intact strand; photoreactivation repair, in which the lethal and mutagenic effects of ultraviolet light are eliminated; and post-replication repair, in which the primary lesions are not repaired, but the gaps in one daughter duplex are filled in by incorporation of portions of the other (undamaged) daughter duplex. Excision repair and post-replication repair are sometimes referred to as "dark repair" because they do not require light.
A DNA helicase that is a component of TRANSCRIPTION FACTOR TFIIH. It plays an essential role in NUCLEOTIDE EXCISION REPAIR, and mutations in this protein are associated with XERODERMA PIGMENTOSUM.
The regular and simultaneous occurrence in a single interbreeding population of two or more discontinuous genotypes. The concept includes differences in genotypes ranging in size from a single nucleotide site (POLYMORPHISM, SINGLE NUCLEOTIDE) to large nucleotide sequences visible at a chromosomal level.
Hard or soft soluble containers used for the oral administration of medicine.
An absence of warmth or heat or a temperature notably below an accustomed norm.
The level of health of the individual, group, or population as subjectively assessed by the individual or by more objective measures.
An envelope of loose gel surrounding a bacterial cell which is associated with the virulence of pathogenic bacteria. Some capsules have a well-defined border, whereas others form a slime layer that trails off into the medium. Most capsules consist of relatively simple polysaccharides but there are some bacteria whose capsules are made of polypeptides.
Branch of medicine concerned with the prevention and control of disease and disability, and the promotion of physical and mental health of the population on the international, national, state, or municipal level.
Non-invasive, endoscopic imaging by use of VIDEO CAPSULE ENDOSCOPES to perform examination of the gastrointestinal tract, especially the small bowel.
The concept concerned with all aspects of providing and distributing health services to a patient population.
Production of new arrangements of DNA by various mechanisms such as assortment and segregation, CROSSING OVER; GENE CONVERSION; GENETIC TRANSFORMATION; GENETIC CONJUGATION; GENETIC TRANSDUCTION; or mixed infection of viruses.
Injuries to DNA that introduce deviations from its normal, intact structure and which may, if left unrepaired, result in a MUTATION or a block of DNA REPLICATION. These deviations may be caused by physical or chemical agents and occur by natural or unnatural, introduced circumstances. They include the introduction of illegitimate bases during replication or by deamination or other modification of bases; the loss of a base from the DNA backbone leaving an abasic site; single-strand breaks; double strand breaks; and intrastrand (PYRIMIDINE DIMERS) or interstrand crosslinking. Damage can often be repaired (DNA REPAIR). If the damage is extensive, it can induce APOPTOSIS.
Interruptions in the sugar-phosphate backbone of DNA, across both strands adjacently.
An exchange of DNA between matching or similar sequences.
Endonucleases that remove 5' DNA sequences from a DNA structure called a DNA flap. The DNA flap structure occurs in double-stranded DNA containing a single-stranded break where the 5' portion of the downstream strand is too long and overlaps the 3' end of the upstream strand. Flap endonucleases cleave the downstream strand of the overlap flap structure precisely after the first base-paired nucleotide, creating a ligatable nick.
Specialized cells of the hematopoietic system that have branch-like extensions. They are found throughout the lymphatic system, and in non-lymphoid tissues such as SKIN and the epithelia of the intestinal, respiratory, and reproductive tracts. They trap and process ANTIGENS, and present them to T-CELLS, thereby stimulating CELL-MEDIATED IMMUNITY. They are different from the non-hematopoietic FOLLICULAR DENDRITIC CELLS, which have a similar morphology and immune system function, but with respect to humoral immunity (ANTIBODY PRODUCTION).
A short pro-domain caspase that plays an effector role in APOPTOSIS. It is activated by INITIATOR CASPASES such as CASPASE 9. Isoforms of this protein exist due to multiple alternative splicing of its MESSENGER RNA.
One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.
A family of intracellular CYSTEINE ENDOPEPTIDASES that play a role in regulating INFLAMMATION and APOPTOSIS. They specifically cleave peptides at a CYSTEINE amino acid that follows an ASPARTIC ACID residue. Caspases are activated by proteolytic cleavage of a precursor form to yield large and small subunits that form the enzyme. Since the cleavage site within precursors matches the specificity of caspases, sequential activation of precursors by activated caspases can occur.
A long pro-domain caspase that has specificity for the precursor form of INTERLEUKIN-1BETA. It plays a role in INFLAMMATION by catalytically converting the inactive forms of CYTOKINES such as interleukin-1beta to their active, secreted form. Caspase 1 is referred as interleukin-1beta converting enzyme and is frequently abbreviated ICE.
The relatively long-lived phagocytic cell of mammalian tissues that are derived from blood MONOCYTES. Main types are PERITONEAL MACROPHAGES; ALVEOLAR MACROPHAGES; HISTIOCYTES; KUPFFER CELLS of the liver; and OSTEOCLASTS. They may further differentiate within chronic inflammatory lesions to EPITHELIOID CELLS or may fuse to form FOREIGN BODY GIANT CELLS or LANGHANS GIANT CELLS. (from The Dictionary of Cell Biology, Lackie and Dow, 3rd ed.)
Lipid-containing polysaccharides which are endotoxins and important group-specific antigens. They are often derived from the cell wall of gram-negative bacteria and induce immunoglobulin secretion. The lipopolysaccharide molecule consists of three parts: LIPID A, core polysaccharide, and O-specific chains (O ANTIGENS). When derived from Escherichia coli, lipopolysaccharides serve as polyclonal B-cell mitogens commonly used in laboratory immunology. (From Dorland, 28th ed)
"Nitrogen Mustard - Chemotherapy Drugs - Chemocare". Retrieved 2017-10-09. Jamieson, E. R.; Lippard, S. J. (1999- ... This process appears to be quite efficient. Even though one or two unrepaired crosslinks are sufficient to inactivate a cell, a ... As a result, the function of these drugs is to serve as enzyme poisons rather than inhibitors. This can be applied to treat ... Qi Wu, Laura A Christensen, Randy J Legerski & Karen M Vasquez, Mismatch repair participates in error-free processing of DNA ...
When it bears a chemotherapy drug, the process is called chemoembolization. Transcatheter arterial chemoembolization (TACE) is ... When the embolus bears a radiopharmaceutical for unsealed source radiotherapy, the process is called radioembolization or ... Embolization microspheres may comprise additional functionality such as drug loading and elution capability, specific ...
The process of nuclear export is responsible for some resistance to chemotherapy drugs. By limiting a cells nuclear export ... During the processing phase of mRNA export, mRNA is covered with RNA-binding proteins, this yields ribonucleoprotein particles ... The level of survivin correlates to how resistance to chemotherapy a cancerous cell is and how likely that cell is to replicate ... mRNPs). Through the process, the correct assortment of proteins is necessary for the mRNPs eventual export. The heterodimeric ...
... and a potent chemotherapy drug, vinblastine. Vintafolide is designed to deliver the toxic vinblastine drug selectively to cells ... Vintafolide binds to the folate receptor and is subsequently taken up by the cell through a natural internalization process ... Once inside the cell, vintafolide's linker releases the chemotherapy drug which kills the cell. Sridharan B (Apr 16, 2012). " ... The drug received orphan drug status in Europe in March 2012. Merck & Co. acquired the development and marketing rights to this ...
However, it is important that the drug is not administered within 24 hours of the actual chemotherapy process. This drug is ... "Statistical Review(s)". Food and Drug Administration: 1-5. December 2004. NEW DRUGS in TRANSPLANTATION Archived 2006-08-11 at ... S2CID 11280180.[permanent dead link] "Kepivance (Palifermin) Drug". RxList. June 2013. "Pharmacology Review(s)". Food and Drug ... The drug comes as a lyophilized powder that must be reconstituted with sterile water for injection before it may be ...
Both grants were for research to develop cancer and AIDS drugs as alternatives to chemotherapy. In 1996, Thorp co-founded ... It was intended to turn a process that previously took months into an electronic process that would instead take hours. In 2001 ... The technology involved using electricity to test compounds that could later become new drugs. ...
"Drug Approval Package: Mylotarg (gemtuzumab ozogamicin)". U.S. Food and Drug Administration (FDA). 7 June 2018. Retrieved 16 ... In the United States, it was approved under an accelerated-approval process by the FDA in 2000, for use in patients over the ... Clinical trial number NCT00372593 for "Combination Chemotherapy With or Without Gemtuzumab in Treating Young Patients With ... Gemtuzumab ozogamicin, sold under the brand name Mylotarg, is an antibody-drug conjugate (a drug-linked monoclonal antibody) ...
This is a process for manufacturing and administering chemotherapy drugs in a nontoxic, proto-drug form. Then, after a time ... Time Delay Toxin Activation (TDTA) belongs to a class of chemotherapy drugs known as High Specificity Anticancer Agents. ... the non-toxic drug is then modified by an activation drug to selectively provide toxic levels of a pharmacologically active ... This minimizes the toxicity to healthy cells, reducing the adverse side-effects of chemotherapy. This idea was first proposed ...
In the process called oxidative addition, low-valent metals often react with alkylating agents to give metal alkyls. This ... In medicine, alkylation of DNA is used in chemotherapy to damage the DNA of cancer cells. Alkylation is accomplished with the ... This mechanism of toxicity is relevant to the function of anti-cancer drugs in the form of alkylating antineoplastic agents. ... Alkyl groups can also be removed in a process known as dealkylation. Alkylating agents are often classified according to their ...
... the medical implications of 13-MTD as an alternative to drug chemotherapy are currently being considered. To understand how 13- ... Essentially, apoptosis is a process of cell death initiated by the presence or absence of certain stimuli.) Thus 13-MTD has ... Beginning in 1985, thousands of cancer patients have accepted Yang Zhen Hua 851 as an alternative to traditional chemotherapy ... Hannun, Y. A. (1997). "Apoptosis and the dilemma of cancer chemotherapy". Blood. 89 (6): 1845-1853. doi:10.1182/blood.V89.6. ...
For instance, L-Methotrexate, a drug used in chemotherapy, is more readily absorbed than the D isomer. Advanced particles and ... can be applied generally as a method for high-throughput screening processes that help discover and evaluate drugs. Using MCE, ... Dittrich PS, Manz A (March 2006). "Lab-on-a-chip: microfluidics in drug discovery". Nature Reviews. Drug Discovery. 5 (3): 210- ... Under the stretching regime, viscous drag dominates causing the stream to narrow creating a smaller droplet. The effect of the ...
Patients being treated with chemotherapy or granulocyte colony stimulating factor, a cytokine drug, may also exhibit toxic ... toxic granulation is a peripheral blood film finding suggestive of an inflammatory process. Toxic granulation is often found in ...
... chemotherapy that acts like radiation (radiomimetic drugs) and certain biochemical processes and metabolites can cause DSBs. ... "Search Orphan Drug Designations and Approvals". Retrieved 2019-08-01. "Search Orphan Drug Designations ... J recombination process]. This process requires them to make DSBs, which are difficult to repair in the absence of ATM. As a ... N-Acetyl-Leucine has been granted multiple orphan drug designations from the U.S. Food & Drug Administration (FDA)and the ...
... the antigen is endocytosed and processed. The processed antigen is then presented in MHCII on the surface of the B-cell. T ... they can serve as drug depots for some anticancer drugs; they can also be activated by some therapies to promote antitumor ... Macrophages can also be deleterious in several ways: for example they can suppress various chemotherapies, radiotherapies and ... The process is called phagocytosis, which acts to defend the host against infection and injury. These large phagocytes are ...
"Pegloticase Drug Approval Package". US FDA. Retrieved 15 May 2017. Wössmann W, Schrappe M, Meyer U, Zimmermann M, Reiter A ( ... However, uric acid plays a complex physiological role in several processes, including inflammation and danger signalling, and ... which occurs when breakdown of tumor cells by chemotherapy releases uric acid and cause the formation of uric acid crystals in ... Urate oxidase is formulated as a protein drug (rasburicase) for the treatment of acute hyperuricemia in patients receiving ...
His activism was pivotal in reforming the FDA drug approval process to expedite HIV and AIDS patients' access to more effective ... The chemotherapy he was receiving to treat the disease put him into cardiac arrest. ...
... a drug used in the chemotherapy of cancer. It is one of the most successful drugs for treating solid tumors. In yeast cells ... Lack of correct ribosomal RNA processing is lethal to cells, explaining the antimetabolic effect of the drug. Mutations in ... The exosome is involved in the degradation and processing of a wide variety of RNA species. In the cytoplasm of cells, it is ... There it plays a role in the processing of the 5.8S ribosomal RNA (the first identified function of the exosome) and of several ...
In a pilot study involving twelve lung cancer patients, chemotherapy drugs were infused with zinc in order to test its ... An alteration in taste or smell may be a secondary process in various disease states, or it may be the primary symptom. The ... It appears that drug-induced dysgeusia can be alleviated by reducing the drug's dose or by substituting a second drug from the ... A major cause of dysgeusia is chemotherapy for cancer. Chemotherapy often induces damage to the oral cavity, resulting in oral ...
This formulation is used in minimally invasive devices, dialysis equipment, for bypass procedures, and chemotherapy drug ... Tygon tubing is used in many markets, including food and beverage, chemical processing, industrial, laboratory, medical, ... These formulations each meet U.S. Food and Drug Administration 3-A and NSF International 51 criteria but they do not comply ... Tygon Medical/Surgical Tubing S-50-HL - Characterized to the latest ISO 10993 standards and U.S. Food and Drug Administration ( ...
It was found that providing combined cytotoxic drugs is better than a single drug; a process called the combination therapy; ... Also, when chemotherapy is given after birth, many of the drugs appear in breast milk, which could harm the baby. Veterinary ... Chemotherapy is the treatment of cancer with one or more cytotoxic anti-neoplastic drugs (chemotherapeutic agents) as part of a ... Some treatments, especially certain chemotherapy drugs given during the first trimester, increase the risk of birth defects and ...
One process for making nanoceramics varies is the sol-gel process, also known as chemical solution deposition. This involves a ... Ceramic nanoparticles have been used as drug delivery mechanism in several diseases including bacterial infections, glaucoma, ... and most commonly, chemotherapy deliver in cancer. The oldest known ceramic nanoparticles have been found in pottery shards ... This process uses a laser technique called two-photon lithography to etch out a polymer into a three-dimensional structure. The ...
Often, steroid-sparing drugs, such as methotrexate (a chemotherapy drug) or other DMARDs, are given to compensate for the ... Lab results are closely monitored during the tapering process to ensure that the disease does not recur.[citation needed] In ... These include other chemotherapy drugs, such as ciclosporin, infliximab, or other DMARDs. Another is intravenous immunoglobulin ... Once the disease process is under control, oral steroids are tapered gradually to minimize their side effects. ...
The clinical development of lipoplatin in adenocarcinomas establishes this drug as the most active platinum drug with ... These processes occurring at the cell membrane level are promoted by the lipid shell of the nanoparticles (disguised as ... It has shown superiority to cisplatin in combination with paclitaxel as a chemotherapy regimen in non-small cell lung cancer ( ... This new drug has successfully finished Phase I, Phase II, and Phase III human clinical trials. ...
... treatment with temozolomide and other chemotherapy drugs). Mutational tumor heterogeneity refers to variations in mutation ... Merlo, L. M. F.; Pepper, J. W.; Reid, B. J.; Maley, C. C. (2006). "Cancer as an evolutionary and ecological process". Nature ... Adaptive therapy may be used to prevent further tumour growth by adjusting drug dose and timing of drug administration based on ... This is attributed to the drug-resistant selective advantage of the tumour cells. Due to the genetic differences within and ...
Some chemotherapy drugs called topoisomerase inhibitors work by interfering with mammalian-type eukaryotic topoisomerases in ... For a video of this process click here. A type I topoisomerase cuts one strand of a DNA double helix, relaxation occurs, and ... This intermediate break allows the DNA to be untangled or unwound, and, at the end of these processes, the DNA backbone is ... If left unabated, this torsion would eventually stop the ability of DNA or RNA polymerases involved in these processes to ...
Chemotherapy drugs associated with CIPN include thalidomide, the epothilones such as ixabepilone, the vinca alkaloids ... Li JJ, Corey EJ (2013). Drug Discovery: Practices, Processes, and Perspectives. John Wiley & Sons. p. 6. ISBN 978-1-118-35446-9 ... "Drug Approval Package: Zyvox". FDA Center for Drug Evaluation and Research. 20 November 2001. Archived from the original on 10 ... "Linezolid". Retrieved 29 December 2018. "Linezolid". Drug Information Portal. U.S. National Library of Medicine. ...
ChemotherapyEdit. Most chemotherapy drugs work by attacking rapidly dividing cells. Rapid cell replication is one of the ... The process results in normal hair loss known as shedding. Growth inhibitors and disordersEdit. In most people, scalp hair ... Consequently, the chemotherapy drugs usually inhibit hair growth. The dose and type of medicine will determine the severity of ... Once the course of chemotherapy has ended, new hair growth may begin after three to 10 weeks. ...
Although advances in chemotherapy had been able to successfully treat tumor throughout the body, there remained an alarming ... Oncologists hypothesized that treatment of this sub-clinical disease with radiation therapy may stamp out the malignant process ... developed that the brain was likely a pharmacologic sanctuary where sub-clinical metastases were protected from cytotoxic drugs ... as well as evidence of equivalent control with alternate forms of treatment such as long-term intrathecal chemotherapy. For ALL ...
Some herbal remedies can cause dangerous interactions with chemotherapy drugs, radiation therapy, or anesthetics during surgery ... Alternative medicine may lead to a false understanding of the body and of the process of science.[169][178] Steven Novella, a ... De Smet, Peter A.G.M. (December 1997). "The Role of Plant-Derived Drugs and Herbal Medicines in Healthcare". Drugs. 54 (6): 801 ... 2006). "Drug-related hepatotoxicity". New England Journal of Medicine. 354 (7): 731-39. doi:10.1056/NEJMra052270. PMID 16481640 ...
"Drug Trials Snapshots: Aklief". U.S. Food and Drug Administration (FDA). 11 October 2019. Archived from the original on 19 ... "Antimicrobial Agents and Chemotherapy. 63 (1). doi:10.1128/AAC.01297-18. PMC 6325184. PMID 30397052.. ... acnes biofilm within the hair follicle worsens this process.[45] If the microcomedone is superficial within the hair follicle, ... Aslam I, Fleischer A, Feldman S (March 2015). "Emerging drugs for the treatment of acne". Expert Opinion on Emerging Drugs. 20 ...
... then the mucosa has likely been affected by an underlying process such as lichen planus or chemotherapy. Pseudomembraneous ... Drug resistance is increasingly more common and presents a serious problem in persons who are immunocompromised. Prophylactic ... The exact process by which Candida species switch from acting as normal oral commensals (saprophytic) state in the carrier to ... Patients who are immunocompromised, either with HIV/AIDS or as a result of chemotherapy, may require systemic treatment with ...
One such drug is aprepitant to prevent the nausea and vomiting that accompanies chemotherapy, typically for cancer. With the ... "Neurochemical Substance P is Key to Understanding Pain Process". Fibromyalgia Library. Retrieved 2008-11-01 ... Chemotherapy induced nausea and vomitingEdit. Further information: Chemotherapy-induced nausea and vomiting and Aprepitant ... Muñoz M, Rosso M, Coveñas R (Jun 2011). "The NK-1 receptor: a new target in cancer therapy". Current Drug Targets. 12 (6): 909- ...
Drug risks[edit]. Filgrastim is typically dosed in the 10 microgram/kg level for 4-5 days during the harvesting of stem cells. ... The chemotherapy or irradiation given immediately prior to a transplant is called the conditioning regimen, the purpose of ... They are collected from the blood through a process known as apheresis. The donor's blood is withdrawn through a sterile needle ... Immunosuppressive drugs are given for a minimum of 6-months after a transplantation, or much longer if required for the ...
ChemotherapyEdit. Patients undergoing chemotherapy are administered drugs designed to kill tumor cells. Although chemotherapy ... This process is repeated for a total of 10 to 30 treatments, depending on the type of tumor. This additional treatment provides ... The toxicity and many side effects of the drugs, and the uncertain outcome of chemotherapy in brain tumors puts this treatment ... Chemotherapy: is a treatment option for cancer, however, it is not always used to treat brain tumors as the blood-brain barrier ...
Androgen receptor antagonists: drugs that bind directly to and block the AR.[57][58] These drugs include the steroidal ... Chabner BA, Longo DL (8 November 2010). Cancer Chemotherapy and Biotherapy: Principles and Practice. Lippincott Williams & ... Androgen synthesis inhibitors are enzyme inhibitors that prevent the biosynthesis of androgens.[62] This process occurs mainly ... Drug class. Bicalutamide, a nonsteroidal antiandrogen and the most widely used androgen receptor antagonist in the treatment of ...
Chemotherapy and aging[edit]. In aged and chemotherapy treated females, oocytes and follicles are depleted by apoptosis ( ... DNA metabolic process. • telomere organization. • positive regulation of DNA ligation. • cellular response to alkaloid. • ... response to drug. • DNA unwinding involved in DNA replication. • cellular response to hydroxyurea. • replication-born double- ... Biological process. • regulation of protein phosphorylation. • strand invasion. • mitotic recombination-dependent replication ...
... including the anticoagulant drug warfarin[40] and the cardiovascular drug nifedipine.[2] ... Evidence that ginger helps alleviate nausea and vomiting resulting from chemotherapy or pregnancy is inconsistent.[2][42][43][ ... scraped off with a bamboo splinter or wooden knife and this process must be done by hand as it is too delicate a process to be ... Spinella M (2001). The Psychopharmacology of Herbal Medications: Plant Drugs That Alter Mind, Brain, and Behavior. MIT Press. ...
... including chemotherapy drugs, is another potential occupational risk. These drugs can cause cancer and other health conditions. ... Initial hiring process[edit]. When hiring Health Care Personnel, the applicant should complete the following:[31] ... Female health workers are exposed to hazardous drugs and chemicals in the workplace which may cause adverse reproductive ... Medical diagnosis providers are health workers responsible for the process of determining which disease or condition explains a ...
Example of drugs that contain such compounds include topotecan, SN-38 (topoisomerase I), doxorubicin, and mitoxantrone ( ... "Letter: Chemotherapy of advanced histocytic lymphomas". Lancet. 1 (7916): 6300-3. doi:10.1016/s0140-6736(75)92521-0. PMC 49488 ... bend during the process of TBP-binding.[16][17][18] ... the toxicity of these drugs have pushed scientists to explore ... Pharmaceutical companies have been designing cancer therapy drugs to target DNA in traditional methods over the years, and have ...
Silverman RB (2004). "3.2.C Theories for Drug-Receptor Interactions". The Organic Chemistry of Drug Design and Drug Action (2nd ... "British Journal of Pharmacology and Chemotherapy. 11 (4): 379-93. doi:10.1111/j.1476-5381.1956.tb00006.x. PMC 1510558. PMID ... Ligand binding is an equilibrium process. Ligands bind to receptors and dissociate from them according to the law of mass ... Theories of drug-receptor interactionEdit. OccupationEdit. The central dogma of receptor pharmacology is that a drug effect is ...
BDNF is a regulator of drug addiction and psychological dependence. Animals chronically exposed to drugs of abuse show ... Biological process. • brain-derived neurotrophic factor receptor signaling pathway. • negative regulation of neuron apoptotic ... "Post-chemotherapy cognitive impairment in patients with B-cell non-Hodgkin lymphoma: a first comprehensive approach to ... There is evidence that antidepressant drugs protect against or reverse hippocampal atrophy.[84] ...
Clinical trial number NCT01324141 for "Topical MTS-01 for Dermatitis During Radiation and Chemotherapy for Anal Cancer" at ... Marberger H, Huber W, Bartsch G, Schulte T, Swoboda P (1974). "Orgotein: a new anti-inflammatory metalloprotein drug evaluation ... "Absence of superoxide dismutase activity causes nuclear DNA fragmentation during the aging process". Biochem. Biophys. Res. ... or as the veterinary anti-inflammatory drug "Orgotein".[4] Likewise, Brewer (1967) identified a protein that later became known ...
The protein degradation processEdit. Ribbon diagram of ubiquitin, the highly conserved protein that serves as a molecular tag ... Adams J (April 2003). "Potential for proteasome inhibition in the treatment of cancer". Drug Discovery Today. 8 (7): 307-15. ... Chemical structure of bortezomib (Boronated form of MG132), a proteasome inhibitor used in chemotherapy that is particularly ... The assembly of the proteasome is a complex process due to the number of subunits that must associate to form an active complex ...
positive regulation of TRAIL biosynthetic process. • positive regulation of apoptotic process. • tumor necrosis factor-mediated ... Scott LJ (March 2017). "Brentuximab Vedotin: A Review in CD30-Positive Hodgkin Lymphoma". Drugs. 77 (4): 435-445. doi:10.1007/ ... Systemic anaplastic large cell lymphoma (sALCL) after failure of at least 1 multiagent chemotherapy regimen[8] ... Biological process. • apoptotic signaling pathway. • cellular response to mechanical stimulus. • response to lipopolysaccharide ...
a b c U.S. Food and Drug Administration: "Listing of Food Additives Status Part I". Archived from the original on January 17, ... The Reichstein process, developed in the 1930s, uses a single pre-fermentation followed by a purely chemical route. The modern ... The same literature claims that ascorbic acid acts as an antioxidant, thereby reducing the adverse effects of chemotherapy and ... The Reichstein process and the modern two-step fermentation processes use sorbitol as the starting material and convert it to ...
"Chemotherapy extravasation guideline" (PDF). WOSCAN Cancer Nursing and Pharmacy Group. September 2009. Retrieved 4 June 2017.. ... It is, therefore, used in medicine in conjunction with other drugs to speed their dispersion and delivery. Common applications ... Hyaluronidases are also thought to play a role in the process of angiogenesis, although most hyaluronidase preparations are ...
The peripheral veins of intravenous drug addicts, and of cancer patients undergoing chemotherapy, become sclerotic and ... Parenteral nutrition is feeding a person intravenously, bypassing the usual process of eating and digestion. The person ... Sometimes injections of hyaluronidase can be used to speed the dispersal of the fluid/drug. Infiltration is one of the most ... Wanger and colleagues had in effect invented the modern I.V.-drip method of drug delivery [...]. ...
Boron nitride nanotubes functionalized with mesoporous silica for intracellular delivery of chemotherapy drugs» Chem. Commun. ... Process. 642 (2015) 104-112 DOI:10.1016/j.msea.2015.06.059. *I.V. Sukhorukova, I.Y. Zhitnyak, A.M. Kovalskii, A.T. Matveev, O.I ... Process. 88[2] (2007) 347-352. *G. Z. Shen, Y. Bando, J. Q. Hu and D. Golberg : «High-symmetry ZnS hepta- and tetrapods ... Process. 85[3] (2006) 265-270. *J. Zhan, Y. Bando, J. Hu and D. Golberg : «Nanofabrication on ZnO nanowires» Appl. Phys. Lett. ...
... is synergistic with chemotherapy, and has been used before, during, and after chemotherapy in susceptible ... The process involves inserting the x-ray tube through the anus into the rectum and placing it against the cancerous tissue, ... Examples of radiosensitizing drugs include: Cisplatin, Nimorazole, and Cetuximab. The effect of radiotherapy on control of ... In 2002, the United States Food and Drug Administration (FDA) approved ibritumomab tiuxetan (Zevalin), which is an anti-CD20 ...
Biological process. • positive regulation of interleukin-8 secretion. • defense response. • negative regulation of growth of ... Current Drug Targets. Inflammation and Allergy. 2 (3): 224-31. doi:10.2174/1568010033484115. PMID 14561157.. ... The Journal of Antimicrobial Chemotherapy. 57 (5): 877-82. doi:10.1093/jac/dkl078. PMID 16556635.. ...
"Use of antiviral drug in poultry is blamed for drug resistant strains of avian flu". BMJ. 331 (7507): 10. doi:10.1136/bmj. ... "Antimicrobial Agents and Chemotherapy. 38 (8): 1864-67. doi:10.1128/aac.38.8.1864. PMC 284652. PMID 7986023.. ... Viruses can replicate only in living cells.[71] Influenza infection and replication is a multi-step process: First, the virus ... The Journal of Antimicrobial Chemotherapy. 44 (1): 6-10. doi:10.1093/jac/44.1.6. PMID 10459804. Archived (PDF) from the ...
BDNF is a regulator of drug addiction and psychological dependence. Animals chronically exposed to drugs of abuse show ... Biological process. • brain-derived neurotrophic factor receptor signaling pathway. • negative regulation of neuron apoptotic ... "Post-chemotherapy cognitive impairment in patients with B-cell non-Hodgkin lymphoma: a first comprehensive approach to ... In the case of some treatments such as drugs[82] and electroconvulsive therapy[83] this has been shown to protect against or ...
"Printing Process Explained". Retrieved 29 August 2012.. *^ Laura Halpin Rinsky; Glenn Rinsky (2009). The Pastry ... Smolinske, Susan C. (1992). Handbook of Food, Drug, and Cosmetic Excipients. p. 7. ISBN 0-8493-3585-X.. ... The Journal of antimicrobial chemotherapy. 54 (2): 577-8. PMID 15269196.. ... The etching process creates a gum adsorb layer within the matrix that attracts water, ensuring that the oil based ink does not ...
The drug became a generic medicine in the U.S. in February 1996, when the market exclusivity held by Bristol-Myers Squibb for ... Antimicrobial Agents and Chemotherapy. 60 (1): 142-150. doi:10.1128/AAC.01335-15. ISSN 0066-4804. PMC 4704194 . PMID 26482303. ... a breakthrough both because of its novel mechanism of action and also because of the revolutionary development process. ... The adverse drug reaction (ADR) profile of captopril is similar to other ACE inhibitors, with cough being the most common ADR. ...
That night, Walt returns to the apartment and finds the drugged-out couple unconscious in bed. In the process of trying to wake ... When Walt had to leave class to vomit (a consequence of his chemotherapy), Hugo comforted him and cleaned up after him. After ... Mexican drug cartel[edit]. Eladio Vuente[edit]. Don Eladio Vuente (played by Steven Bauer) is the head of a drug cartel in ... Caldera for immediate help, and then attack the headquarters of the rival drug gang to recover the "stolen" drugs that Gus has ...
... is created by stellar nucleosynthesis, mostly by the s-process in asymptotic giant branch stars. The s-process is a ... Baselt, R. (2008). Disposition of Toxic Drugs and Chemicals in Man (8th ed.). Foster City, CA: Biomedical Publications. pp. 693 ... and chemotherapy.[25] ... releasing high energy electrons in the process.[47] Because of ... The ore concentrates are mostly sulfidic; they are converted to the oxides by heating under air in a process known as roasting ...
While in hospital, Megrahi underwent chemotherapy treatment, receiving the drug Docetaxel. He was discharged from hospital on 2 ... "UN Observer to the Lockerbie Trial says 'totalitarian' appeal process bears the hallmarks of an "intelligence operation"". ... he resumed chemotherapy, making regular visits to hospital for chemotherapy sessions and other intensive treatment.[81][82] ... "Bomber freed to die is now being given 'miracle cure' drug". The Malta Independent. 14 August 2010. Archived from the original ...
Cryotherapy (the process of freezing the tumor), hormonal therapy, and chemotherapy may also be offered if initial treatment ... "FDA approves new drug for advanced prostate cancer" (Press release). Food and Drug Administration. 15 May 2013. Archived from ... chemotherapy, oral chemotherapeutic drugs (temozolomide/TMZ), cryosurgery, hormonal therapy, or some combination.[110][111] ... Active surveillance, surgery, radiation therapy, hormone therapy, chemotherapy[2]. Prognosis. 5-year survival rate 99% (US)[4] ...
Chemotherapy Drug Evaluation at a Veterinary Teaching Hospital. HHE Program investigators evaluated concerns about reproductive ... Evaluation of Eye and Respiratory Symptoms at a Poultry Processing Facility. HHE Program investigators evaluated symptoms at a ... Some employees reported symptoms that have been reported with occupational exposure to chemotherapy drugs but also have other ... and using biological safety cabinets that do not recirculate exhaust air when preparing volatile chemotherapy drugs. Employees ...
... improved communication regarding the process, and ensuing error reduction. ... Each elicitation method and the subsequent validation discussions contributed uniquely to understanding the chemotherapy ... treatment plan review process, supporting rapid adoption of changes, ... Using process elicitation and validation to understand and improve chemotherapy ordering and delivery Jt Comm J Qual Patient ...
... oral spray is a new drug formulation in development to prevent nausea and vomiting after chemotherapy. Zensana information ... Development Status and FDA Approval Process for Zensana. Date. Article. Aug 1, 2007. Par Pharmaceutical Licenses North American ... Treatment for: Nausea/Vomiting, Chemotherapy Induced. Zensana (ondansetron hydrochloride) is an oral spray 5-HT3 antagonist ... Mobile Apps. The easiest way to lookup drug information, identify pills, check interactions and set up your own ...
Purchase Drug Resistance As a Biochemical Target in Cancer Chemotherapy - 1st Edition. Print Book & E-Book. ISBN 9780127022956 ... We cannot process tax exempt orders online. If you wish to place a tax exempt order please contact us. ... Drug Resistance As a Biochemical Target in Cancer Chemotherapy 1st Edition. Write a review ... Drug Resistance as a Biochemical Target in Cancer Chemotherapy covers the proceedings of the 13th Bristol-Myers Squibb ...
Chemotherapy can be an effective way of treating cancer. However, while it destroys cancer cells, it can also have adverse ... target specific sites or processes. What does chemotherapy do?. Chemotherapy drugs can:. *prevent cell division ... What is chemotherapy?. Share on Pinterest. Chemotherapy drugs treat cancer by stopping cancerous cells from dividing.. A ... Many chemotherapy drugs have adverse effects that can be severe. However, if a doctor recommends a person has chemotherapy, ...
Pathologic Processes. Drug-Related Side Effects and Adverse Reactions. Chemically-Induced Disorders. Radiation Injuries. Wounds ... Drug: dexrazoxane hydrochloride Drug: doxorubicin hydrochloride Drug: etoposide Drug: prednisone Drug: vincristine sulfate ... RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. ... Chemoprotective drugs, such as dexrazoxane, may protect normal cells from the side effects of chemotherapy. ...
Pathologic Processes. Drug-Related Side Effects and Adverse Reactions. Chemically-Induced Disorders. Radiation Injuries. Wounds ... Patients with cancer who are undergoing or have completed the chemotherapy drugs doxorubicin and/or trastuzumab. ... The use of certain blood pressure drugs show promise, especially in patients with hypertension. However, in addition to drug ... after completion of chemotherapy. While an echocardiogram is part of standardized surveillance for patients on these drugs, ...
Pathologic Processes. Drug-Related Side Effects and Adverse Reactions. Chemically-Induced Disorders. Radiation Injuries. Wounds ... MRI in Detecting Heart Damage in Patients With Cancer Receiving Chemotherapy. This study is currently recruiting participants. ... To test the ability of the pre- to post-anthracycline-based chemotherapy (Anth-bC) changes in our MRI platform generated ... Diagnostic procedures, such as MRI, may help doctors predict whether patients will have heart damage caused by chemotherapy in ...
When it bears a chemotherapy drug, the process is called chemoembolization. Transcatheter arterial chemoembolization (TACE) is ... When the embolus bears a radiopharmaceutical for unsealed source radiotherapy, the process is called radioembolization or ... Embolization microspheres may comprise additional functionality such as drug loading and elution capability, specific ...
Drug: Oral complex C3 curcumin + chemotherapy Drug: Chemotherapy only Phase 1 Phase 2 ... Neoplastic Processes. Pathologic Processes. Curcumin. Molecular Mechanisms of Pharmacological Action. Antineoplastic Agents. ... Undergone chemotherapy (other than adjuvant for CRC) or participating in another drug study. ... during FOLFOX-based chemotherapy and continued for the duration of the chemotherapy course. ...
... these results indicate the conventional pig could be an appropriate animal model to study renal drug elimination processes in ... However, information about the contribution of distinct renal elimination processes [glomerular filtration rate (GFR), ... However, information about the contribution of distinct renal elimination processes (glomerular filtration rate (GFR), ... Chemotherapy 39 (1), 6-12. doi: 10.1159/000238967. PubMed Abstract , CrossRef Full Text , Google Scholar ...
One strategy to inhibit tumor cell repopulation is the use of cytostatic compounds between courses of lethal chemotherapy. In ... Repopulation of cancer cells escaping lethal chemotherapy is a critical factor hindering treatment success. ... Cell Cycle / drug effects * Cell Death / drug effects * Cell Growth Processes / drug effects ... One strategy to inhibit tumor cell repopulation is the use of cytostatic compounds between courses of lethal chemotherapy. In ...
Cellular processing of platinum anticancer drugs. Nat Rev Drug Discov 2005; 4: 307-20PubMedCrossRefGoogle Scholar ... Predicting drug response and toxicity based on gene polymorphisms. Crit Rev Oncol Hematol 2005; 54: 171-96PubMedCrossRefGoogle ... Cisplatin-based adjuvant chemotherapy in patients with completely resected non-small-cell lung cancer. N Engl J Med 2004; 350: ... DNA repair by ERCC1 in non-small-cell lung cancer and cisplatin-based adjuvant chemotherapy. N Engl J Med 2006; 355: 983-91 ...
Process. Black. • ergot alkaloids (used in the treatment of migraines e.g. ergotamine and methysergide). • oxytocin (used to ... intravenous busulfan (used in chemotherapy to treat cancer).. Pregnancy and breast-feeding. If you are pregnant or are breast- ... Mobile Apps. The easiest way to lookup drug information, identify pills, check interactions and set up your own ... The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or ...
MATLAB image processing and statistical analyses give researchers an objective computational method for measuring the ability ... of drugs in development to inhibit cancer metastasis. ... EMT also diminishes the effectiveness of chemotherapy ... Using Image Processing and Statistical Analysis to Quantify Cell Scattering for Cancer Drug Research. By Gretchen Argast, OSI ... Until recently, measuring how a drug affected one aspect of EMT, cell scattering, was a manual process that involved ...
thrombolytic drug (thrŏm´bəlĬt´Ĭk) or clot-dissolving drug, substance, such as streptokinase or tissue plasminogen activator ( ... Chemotherapy- Treatment of an illness with chemical agents. The term is usually used to describe the treatment of cancer with ... drugs.. Dialysis- A process used in people whose kidneys are not working well. By way of a filtering machine, dialysis ... The drugs must be given within a few hours of the beginning of a stroke or heart attack. This type of treatment is not right, ...
... drug-resistance mutations in children with acute lymphoblastic leukemia who relapse ... Investigators proposed a two-step process to explain later relapse. The model suggested that relapse occurred when partially ... Chemotherapy sometimes set the stage for drug-resistant leukemia at relapse. An international collaboration has identified ... The now drug-resistant cells divide and eventually cause relapse.. "This suggests drug resistance is not a foregone conclusion ...
... height and weight affect how your body processes doxorubicin. ... The researchers will look at the chemotherapy drug doxorubicin ... the way the cancer drugs are processed in the body will be different for each person. This may change levels of the drug in the ... A study looking at how doxorubicin chemotherapy is processed in people with osteosarcoma, Ewings tumours and Hodgkin lymphoma ... A study looking at how doxorubicin chemotherapy is processed in people with osteosarcoma, Ewings tumours and Hodgkin lymphoma ...
"Nitrogen Mustard - Chemotherapy Drugs - Chemocare". Retrieved 2017-10-09.. *^ Jamieson, E. R.; Lippard, S. J. ( ... This process appears to be quite efficient. Even though one or two unrepaired crosslinks are sufficient to inactivate a cell, a ... The level of BRCA1 expression is potentially an important tool for tailoring chemotherapy in lung cancer management.[29][30] ... Cole et al.[22] and Sinden and Cole[23] presented evidence that a homologous recombinational repair process requiring the ...
Advances in nano drugs for cancer chemotherapy. Curr. Cancer Drug Targets 11: 135-146. ... Proapoptotic Chemotherapeutic Drugs Induce Noncanonical Processing and Release of IL-1β via Caspase-8 in Dendritic Cells. ... Proapoptotic Chemotherapeutic Drugs Induce Noncanonical Processing and Release of IL-1β via Caspase-8 in Dendritic Cells ... Proapoptotic Chemotherapeutic Drugs Induce Noncanonical Processing and Release of IL-1β via Caspase-8 in Dendritic Cells ...
Sanofi US launches second PiPH innovation challenge to improve drug development process Today, Sanofi US launched its second ... New mechanism of chemotherapy resistance in triple-negative inflammatory breast cancer Researchers at Roswell Park Cancer ... Two new drug compounds appear to be effective in treating endometriosis Two new drug compounds - one of which has already ... Romidepsin drug shows surprising benefit in preclinical studies of inflammatory breast cancer A drug now used to treat a type ...
... that aggressive sarcomas use to promote drug resistance and cancers spread plus evidence of how to reverse the process. ... Investigators showed that tumors can use the same pathway to resist chemotherapy by sequestering drugs in lysosomes and then ... of a cancer cell that up-regulates the process of lysosomal exocytosis to transition to a more invasive/migratory and drug ... "This study helps to answer a central question of cancer biology, which is how tumor cells become invasive and drug resistant," ...
Most chemotherapy drugs are given as liquids that are slowly injected into a vein. Some chemotherapy is ... DNA directly; others get in the way of processes that help cancer cells build DNA. ...
Delivering heated chemotherapy drugs into the abdomen (HIPEC). The first phase of treatment, CRS, involves removing any visible ... This complex surgical procedure is a two-step process:. *Surgically removing any visible tumor or cancer (CRS) ... How will the chemotherapy affect me?. The one-time dose of chemotherapy delivered into the abdomen at an elevated temperature ... the traditional side effects of oral or intravenous chemotherapy drugs may be avoided; however, many patients do still require ...
Tumors backfire on chemotherapy. Some patients with breast cancer receive chemotherapy before the tumor is removed with surgery ... Pediatric leukemia super drug could be developed…. Northwestern Medicine scientists have discovered two successful therapies ... BBK Worldwide makes clinical engagement process easier with mobile apps Details Development 17 June 2014 BBK Worldwide, a ... "Mobile will continue to revolutionize every step of the clinical trial process, and we will continue to innovate in this space ...
Combining a platinum chemotherapy agent and the diabetes drug rosig...If pairing the drugs has the same synergistic effect in ... Drug,Dramatically,Boosts,Potency,of,Platinum,Chemotherapy,medicine,medical news today,latest medical news,medical newsletters, ... A widely used diabetes drug dramatically boosted the potency of platin... ... Processed Meat, Diabetes connection Found 9. Pancreatic Cancer may be linked to Diabetes. 10. Gestational Diabetes linked to ...
This suggests that SurVaxM has not detracted from the effectiveness of chemotherapy treatment in these patients.. A Potential ... Glioblastoma Vaccine to Be Tested as Orphan Drug, Easing Clinical Trials Process. The designation recognizes that the vaccine, ... Although the orphan drug designation does not guarantee FDA approval, it does indicate a vetting of the drug by the FDA which ... articles/glioblastoma-vaccine-to-be-tested-as-orphan-drug-easing-clinical-trials-process ...
Chemotherapy: These drugs treat cancer by killing cells that are in the process of dividing. They also kill healthy cells ... Immunomodulatory drugs: These drugs are the workhorses of multiple myeloma treatment. They work on your immune system. Some ... Steroids: These drugs are used at all stages of the disease. High doses can kill multiple myeloma cells. Theyre also used to ... Special Report Harnessing the Power of AI to Speed Drug Development * Get Our Newsletters Health News and Information, ...
Chemotherapy. Chemotherapy entails the use of specific drugs to treat brain tumors. These drugs tend to be used when treating ... Chemotherapy can also cause the tumor cells to artificially begin the process of dying. ... would like to process and share personal data (e.g., mobile ad id) and data about your use of our site (e.g., content interests ... If this is the case, they may use surgery to remove as much of it as possible before using radiation or chemotherapy to remove ...
Radiotherapy is the process of applying radiation on the tumors [gamma rays]. Chemotherapy is the process of using drugs to ... In Chemotherapy What is oral chemotherapy? Oral chemotherapy is given by mouth in the form a pill, capsule, or liquid. This is ... In Chemotherapy What is the cure for chemotherapy? Chemotherapy is used as a treatment in the fight against cancer.Chemo ... In Chemotherapy What is chemotherapy? Chemotherapy is the use of chemical agents to treat or control disease or mental illness ...
  • Chloro ethyl nitroso urea (CENU), specifically carmustine (BCNU), are crosslinking agents that are widely used in chemotherapy, particularly for brain tumors. (
  • A team of researchers has devised a new way to target tumors with cancer-fighting drugs, a discovery that may lead to clinical treatments for cancer patients. (
  • Investigators showed that tumors can use the same pathway to resist chemotherapy by sequestering drugs in lysosomes and then purging them. (
  • A widely used diabetes drug dramatically boosted the potency of platinum-based cancer drugs when administered together to a variety of cancer cell lines and to mice with tumors, scientists from Dana-Farber Cancer Institute report. (
  • Combining a platinum chemotherapy agent and the diabetes drug rosiglitazone halted or shrank mouse tumors as much as three times more effectively than either of the drugs given alone, according to the article in the May issue of Cancer Cell. (
  • If pairing the drugs has the same synergistic effect in humans, the researchers say, it could improve control of ovarian, lung and other cancers routinely treated with platinum-based chemotherapy, to which tumors eventually become resistant. (
  • The drug combination also had striking growth-suppressing results when given to mice with human lung and ovarian tumors implanted under their skin and in mice that had received a chemical that causes them to develop colon cancer, explained Spiegelman, who is also a professor of cell biology at Harvard Medical School. (
  • Radiotherapy is the process of applying radiation on the tumors [gamma rays]. (
  • Chemotherapy is the process of using drugs to destroy the tumors. (
  • When used in conjunction with chemotherapy, complete destruction of tumors in mice has been demonstrated. (
  • Snipstad's method targets cancerous tumors with chemotherapy so that more of the drug reaches cancer cells while protecting healthy cells. (
  • WEDNESDAY, Dec. 26 (HealthDay News)-- Chemotherapy drugs known as anthracyclines help boost survival for women with HER2-positive breast cancer who have undergone surgery, but they may not offer any survival benefit for those with HER2-negative tumors. (
  • Our study provides convincing statistical evidence that the added benefit of adjuvant chemotherapy with anthracyclines is confined to women who have breast tumors in which HER2 is overexpressed or amplified," she said. (
  • The new study suggests the drugs work best for those women whose tumors are HER2-positive. (
  • For women with HER2-negative tumors, however, there was no difference in survival between the chemotherapy regimens. (
  • Heated intraperitoneal chemotherapy (HIPEC) is a heated chemotherapy wash administered to the abdominal cavity after surgery to remove tumors and lesions. (
  • HIPEC surgery is the removal of malignant tumors before chemotherapy treatment . (
  • After the tumors are removed, doctors will administer the heated chemotherapy wash to target remaining cancer cells. (
  • These procedures, often performed with chemotherapy, remove all visible tumors from the chest area and improve quality of life. (
  • When the embolus bears a radiopharmaceutical for unsealed source radiotherapy , the process is called radioembolization or selective internal radiation therapy (SIRT). (
  • All patients receive 3 courses of chemotherapy consisting of doxorubicin and etoposide on days 0 and 1, bleomycin and vincristine on days 0 and 7, cyclophosphamide on day 0, and prednisone on days 0-6. (
  • This study is looking to see if things such as your sex, stage of physical development, height and weight affect how your body processes a drug called doxorubicin. (
  • The aim of this study is to find out if your sex, stage of development into an adult, height and weight can affect the way your body processes doxorubicin. (
  • We found a heretofore unappreciated role for caspase-8 as a major pathway for IL-1β processing and release in murine bone marrow-derived dendritic cells (BMDC) costimulated with TLR4 agonists and proapoptotic chemotherapeutic agents such as doxorubicin (Dox) or staurosporine (STS). (
  • Researchers also demonstrated that blocking lysosomal exocytosis helped to restore tumor cell sensitivity to chemotherapy, specifically to the drug doxorubicin. (
  • The release of lysosome-trapped doxorubicin by excessive lysosomal exocytosis declined in tumor cells treated with the hypertension drug verapamil, and sensitivity to chemotherapy increased. (
  • Doxorubicin belongs in the class of drugs called anthracyclines. (
  • A total of 47 breast cancer patients who were scheduled to receive postoperative adjuvant anthracycline‑based chemotherapy, i.e., 5‑fluorouracil (5‑FU) + cyclophosphamide + epirubicin (FEC regimen), 5‑FU + cyclophosphamide + doxorubicin/pirarubicin (FAC regimen), cyclophosphamide + doxorubicin/pirarubicin (AC regimen) and cyclophosphamide + epirubicin (EC regimen), were entered in the study. (
  • The researchers studied bone loss in mice treated with two common chemotherapy drugs - doxorubicin and paclitaxel - as well as in mice that received radiation to one limb, to understand whether the bone loss effects were similar in different types of cancer therapies. (
  • In a set of studies the chemotherapy drug doxorubicin was used to treat mice. (
  • Since anthracyclines (such as doxorubicin and epirubicin) were introduced in the 1980s, they have been widely used as supplementary chemotherapy for breast cancer, said Dr. Alessandra Gennari, a medical oncologist at the National Cancer Research Institute in Genoa, Italy, and lead author of the study. (
  • Common HIPEC drugs include cisplatin , mitomycin and doxorubicin. (
  • Cisplatin-based adjuvant chemotherapy in patients with completely resected non-small-cell lung cancer. (
  • Low ERCC1 expression correlates with prolonged survival after cisplatin plus gemcitabine chemotherapy in non-small cell lung cancer. (
  • [7] Similar to nitrogen mustards, cisplatin is used frequently in chemotherapy treatment - especially for testicular and ovarian cancers. (
  • In addition to rosizitaglone, the scientists tested pioglitazone and an experimental compound made by Glaxo Smith Kline, combining each of them with cisplatin, carboplatin and oxalyplatin -- all commonly used chemotherapy drugs that destroy cancer cells by damaging their DNA. (
  • The present study investigated the apoptotic effect of cisplatin in human hair follicle dermal papilla cells and HaCaT keratinocytes, and determined the identity and role of specific reactive oxygen species (ROS) involved in the process. (
  • Inhibition of ROS generation by antioxidants inhibited the apoptotic effect of cisplatin, indicating the role of ROS in the process. (
  • Since CIA is a major side effect of cisplatin and many other chemotherapeutic agents with no known effective treatments, the knowledge gained from this study could be useful in the design of preventive treatment strategies for CIA through localized therapy without compromising the chemotherapy efficacy. (
  • Cisplatin, a chemotherapy medication, has been the preferred choice to treat a number of cancers, but it has some severe side effects. (
  • In the process of killing the cancer cells, Cisplatin often causes irreversible damage to the neighboring healthy cells. (
  • Cisplatin and 5-FU are conventional drugs that act by inducing DNA damage or preventing DNA production, leading to a reduction of cancer cells. (
  • Inhibitors of proteins that inactivate the tumor suppressor protein pRB, when used along with the conventional anti-cancer drug cisplatin could increase tumor cell death, but have an opposite disastrous effect when used along with 5-FU. (
  • Using drugs that reverse the inactivation of tumor suppressor protein pRB, along with conventional drug cisplatin could kill cancer cells but have an opposite effect with 5-FU. (
  • Two of the chemotherapeutic drugs, cisplatin and 5-FU act by inducing DNA damage or prevent DNA production, thus causing a reduction in the number of cancer cells. (
  • Cisplatin is a well-known chemotherapeutic drug that was discovered in 1845 and licensed for medical use in 1978/1979. (
  • Chemoprotective drugs, such as dexrazoxane, may protect normal cells from the side effects of chemotherapy. (
  • To observe any changes to the neuropathic side-effects of chemotherapy. (
  • She has tried organic and no-sugar diets, Kangen Water, other dietary supplements and vitamin K to help combat the side effects of chemotherapy and radiation. (
  • Randomized study of adjuvant chemotherapy for completely resected stage I, II, or IIIA non-small-cell lung cancer. (
  • What is Adjuvant chemotherapy? (
  • An increasing proportion of patients with early-stage breast cancer are treated with taxanes as postoperative adjuvant chemotherapy. (
  • This type of treatment is called adjuvant chemotherapy . (
  • However despite the tremendous progress, cancer treatments often come with adverse side-effects, perhaps none are more serious or devastating than chemotherapy induced heart failure. (
  • EMT also diminishes the effectiveness of chemotherapy treatments that target epithelial cells. (
  • Thrombolytic therapy is also used to dissolve blood clots that form in catheters or tubes put into people's bodies for medical treatments, such as dialysis or chemotherapy. (
  • The vaccine's developers hope this means that the required size of phase 3 trials of SurVaxM will be smaller than for drugs designed to treat non-rare diseases because of the small pool of possible study participants and the lack of effective treatments for glioblastoma. (
  • SurVaxM boosts the immune system's ability to attack the protein survivin, whose activity otherwise contributes to cancer's resistance against treatments such as chemotherapy and radiotherapy. (
  • We guided these stem cells to become brain cells, where we could then investigate mechanisms of the disease process and test the effects of newer antibody treatments for AD. (
  • Other treatments, such as radiation therapy and chemotherapy, might also be recommended. (
  • Accordingly, there is a need for treatments that can maintain and/or improve the QOL and immune function of breast cancer patients receiving anthracycline-based chemotherapy. (
  • The chemotherapy agents most associated with these symptoms are the alkylating agents (listed above in the previous section) with emphasis on cyclophosphamide or combination treatments including alkylating agents. (
  • Chemotherapy treatments for lymphomas vary widely depending on the patient and the stage of the disease. (
  • Chemotherapy is not always the best option for all lymphomas, and new treatments are emerging. (
  • In all situations, the treatments induced the process of cellular senescence. (
  • Chemotherapy is a lifesaving mainstay of many cancer treatments but it can be a rough ride. (
  • More than 100 chemotherapy or chemo drugs are used to treat cancer - either alone or in combination with other drugs or treatments. (
  • Cancer treatments, including chemotherapy, have helped many of those who have been diagnosed with the disease to go on to live healthy lives. (
  • And because current treatments aren't specifically targeted to cancer cells, only 0.01 percent of chemotherapy drugs actually reach the tumor and its diseased cells. (
  • Ideally, our compounds would be combined with other treatments to kill cancer cells faster and more efficiently -- and with fewer adverse effects, which are an all-too-common problem with standard chemotherapies. (
  • Mikaelian believes the dietary supplement can be integrated into traditional western medicine: The product can be used on its own or in conjunction with surgery, chemotherapy, radiation, hormone therapy or other conventional treatments. (
  • Conventional treatments for cancer also have frightening qualities to them: disfiguring surgery, arduous chemotherapy, and treatment with invisible radiation. (
  • After lengthy or multiple chemotherapy treatments , the kidneys may become averse to functioning at full strength, which causes our bodies to retain water and swell. (
  • The type of drug your doctor chooses to treat you can depend on your age, the type and stage of disease, your response to previous treatments and other factors. (
  • This topic is followed by a discussion on the interactions among steroid hormones, steroid hormone receptors, antiandrogens, biological-response modifiers, and cytotoxic drugs in human breast cancer. (
  • [2] These agents are often introduced as a pharmaceutical and are used in cytotoxic chemotherapy . (
  • Handling of cytotoxic drugs by healthcare workers: A review of the risks of exposure. (
  • Vorinostat is an anti-cancer ("antineoplastic" or "cytotoxic") chemotherapy drug. (
  • Conventional cytotoxic medications and chemotherapies usually destroys rapidly dividing cancer cells by inhibiting cell division process. (
  • The process description (or process definition), written in a notation developed for software quality assessment purposes, guided process validation (which consisted of direct observations and semistructured interviews to confirm the elicited details for the treatment plan portion of the process). (
  • Each elicitation method and the subsequent validation discussions contributed uniquely to understanding the chemotherapy treatment plan review process, supporting rapid adoption of changes, improved communication regarding the process, and ensuing error reduction. (
  • Doctors often recommend chemotherapy as a treatment for cancer. (
  • A person will often have chemotherapy as part of an overall treatment plan, which may also include surgery and radiation therapy . (
  • Chemotherapy is an invasive treatment that can have severe adverse effects both during the therapy and for some time after. (
  • However, early treatment involving chemotherapy can sometimes achieve a complete cure. (
  • If these blood counts are low before treatment, the person may need to wait until they reach healthy levels before starting chemotherapy. (
  • Oral curcumin (complex C3, Sabinsa Corp, Utah) will be given to patients with inoperable colorectal metastases who will be commencing standard care oxaliplatin-based (FOLFOX) chemotherapy for up to 12 cycles(approximately 6 months) of treatment. (
  • Repopulation of cancer cells escaping lethal chemotherapy is a critical factor hindering treatment success. (
  • The aim of our study was to evaluate the progression-free survival and tolerability of adjuvant treatment with platinum-based chemotherapy in patients with NSCLC, according to common DNA repair gene polymorphisms and ERCC1 expression. (
  • The previously reported impact of DNA repair gene polymorphisms on platinum-based chemotherapy treatment of advanced NSCLC was not observed in our study in the adjuvant setting. (
  • Newswise - Chemotherapy has helped make the most common childhood cancer one of the most curable, but researchers have evidence that the treatment may also prime some patients for relapse. (
  • Results published in the journal Blood reported that treatment-induced mutations cause drug resistance in some patients whose acute lymphoblastic leukemia (ALL) returns. (
  • Our study reveals the evolution dynamics of pediatric ALL, which suggest for the first time that chemotherapy treatment, particularly thiopurines, can cause mutations that lead to drug resistance in patients," said study co-corresponding author Jinghui Zhang , Ph.D., chair of the St. Jude Children's Research Hospital Department of Computational Biology. (
  • Thiopurines are a class of drugs used in most phases of ALL treatment. (
  • The analysis revealed that about 20% of these patients had treatment-related mutations at relapse, some associated with drug resistance. (
  • The model suggested that relapse occurred when partially drug-resistant tumor cells that were present at diagnosis acquired treatment-related mutations. (
  • Surgical oncologist Fabian Johnston discusses cytoreductive surgery plus hyperthermic intraperitoneal chemotherapy (HIPEC), a highly concentrated, heated chemotherapy treatment that is delivered directly to the abdomen during surgery and has been shown to be effective against primary peritoneal and other types of cancer. (
  • A technique called tumor debulking, or cytoreductive surgery (CRS), and hyperthermic intraperitoneal chemotherapy (HIPEC) has been shown to be an effective treatment option for certain patients with peritoneal surface malignancy. (
  • A vaccine for glioblastoma - a form of brain cancer - has received orphan drug designation from the FDA, which could make it easier for scientists to test the treatment in clinical trials. (
  • The vaccine would be administered as part of the typical treatment process. (
  • Three of eight evaluable patients had stable disease 12 months after starting the treatment, and no drug-related side effects beyond those deemed mild or moderate occurred. (
  • Chemotherapy is used as a treatment in the fight against cancer.Chemo treatment must be administered conservatively and by fullyqualified staff. (
  • To evaluate this treatment modality correctly at the present and to decide the new role of intra-arterial infusion chemotherapy, interventional radiologists should understand their very important role on intra-arterial infusion chemotherapy. (
  • A prospective randomized trial of regional versus systemic continuous 5-fluorodeoxyuridine chemotherapy in the treatment of colorectal liver metastases. (
  • Results of a prospective randomized trial of continuous regional chemotherapy and hepatic resection as treatment of hepatic metastases from colorectal primaries. (
  • Harmantas A, Rotstein LE, Langer B. Regional versus systemic chemotherapy in the treatment of colorectal carcinoma metastatic to the liver. (
  • Other risk factors include age, family history, a diagnosis of polycystic ovary syndrome and prior use of the breast cancer treatment drug tamoxifen. (
  • the choice of parent cell line, dose of selecting agent, treatment interval, and optimizing the dose of drug for the parent cell line. (
  • Doses of drug administered are low, and a pulsed treatment strategy is often used where the cells recover in drug-free media. (
  • Resistant cell lines were developed from parental Chinese hamster cells using a stepwise increase in treatment dose with actinomycin D. This induced 2500-fold greater resistance to the drug than that observed in the parental cells. (
  • 8 . A method as claimed in claim 1 wherein the medical treatment to be delivered comprises administration of chemotherapy. (
  • This may be due to radiation treatment, chemotherapy, or a brain tumor or its treatment. (
  • Kids who had chest radiation and/or chemo with a class of drugs called anthracycline are at higher risk for heart problems up to 20 years or longer after treatment. (
  • Therefore, resistance to chemotherapy represents a major problem in the treatment of several tumor types. (
  • Resistance can occur prior to drug treatment (primary or innate resistance) or may develop over time following exposure to the drug (acquired resistance). (
  • For over 40 years, mainstay of localized sarcoma treatment included surgical resection followed by neoadjuvant or adjuvant radiation or chemotherapy. (
  • Targeted therapy doesn't often cure cancer by itself, but it can be very useful when combined with other types of cancer treatment such as surgery, chemotherapy or radiation therapy. (
  • Scientists at The Scripps Research Institute have discovered a potential new use for the drug closantel, currently the standard treatment for sheep and cattle infected with liver fluke. (
  • Currently, the only drug available for mass treatment of river blindness is ivermectin, and it now appears that resistance to that drug is emerging. (
  • Chemotherapy - This is related to the type of drug, dose and length of treatment. (
  • Regardless, it is important that you do not become pregnant once you agree upon, and are undergoing chemotherapy treatment. (
  • The process where a patient learns about all the aspects of a medical treatment or clinical trial before agreeing to participate. (
  • The side effects are largely due to the fact that, because chemotherapy is applied to the whole body (a "systemic" treatment), it not only destroys cancer cells in a specific location but harms many normal, noncancerous cells as well. (
  • But for lymphoma patients--especially non-Hodgkin lymphoma patients--chemotherapy is often an essential treatment because the disease often spreads throughout the body. (
  • In fact, there are countless possible treatment regimens because drugs are frequently used in combination. (
  • Exposure to chemotherapy and radiation during cancer treatment leads to bone loss and increases the risk of osteoporosis and fractures. (
  • During treatment, chemotherapy attacks all of the body's cells, not just cancer cells. (
  • In patients with locally advanced disease (cancers that have already spread to nearby tissue or lymph nodes), radiation therapy has long been the treatment of choice, typically combined with chemotherapy. (
  • As many cancers fail to respond - or respond poorly, to treatment, it is also valuable to gain insights into the molecular reasons underlying this drug resistance, as this information could potentially inform alternative treatment options. (
  • In addition, we have also shown that there is one critical interaction between the key molecular players involved in this process that dictates the effectiveness of some treatment options. (
  • Anticancer drugs given after surgery/treatment to assist the body in fighting remaining cancerous cells. (
  • The treatment of cancer using more than one drug. (
  • Treatment of malnutrition caused by food aversion following chemotherapy. (
  • OTCQX: RHHBY) today announced that China National Medical Products Administration (NMPA) has approved Tecentriq® (atezolizumab) in combination with chemotherapy (carboplatin and etoposide) for the first-line treatment of patients with extensive-stage small cell lung cancer (ES-SCLC). (
  • If a treatment only worked in the absence of chemotherapy, for example (as some alternative cancer therapy proponents claim about their methods) or could only cure early cases of cancer, these ethical obstacles would prevent researchers from finding out. (
  • Treatment with these newer agents and traditional chemotherapy drugs has allowed many cancer patients to obtain a response or disease stabilization. (
  • When chemotherapy is a component of your mesothelioma treatment, you may experience swelling in your hands and feet. (
  • And it is not uncommon for mesothelioma patients to receive a combination of two or more drugs during treatment. (
  • Considering most mesothelioma patients are older than 51,you may have already spoken to your doctor about your sodium consumption.Creating diet restrictionsbased onhow your body reacts to chemotherapy treatment may be the best way to minimize adverse reactions. (
  • How did you reduce swelling from chemotherapy treatment? (
  • The most common treatment for mesothelioma involves a combination of surgery, chemotherapy and radiation therapy. (
  • Cancer's global impact of a trillion dollars makes it critical to develop new drugs and other novel treatment methods. (
  • Some new drugs that act on the pRB pathway, enhancing its functioning and controlling cell growth to the right amount are under clinical trials and may become alternative anti-cancer treatment soon. (
  • A constant evaluation program monitoring P. falciparum drug sensitivity is necessary for preserving the efficacy of the established treatment. (
  • If current drugs or other types of cancer treatment no longer benefit you, you may wish to explore joining a clinical trial. (
  • We investigated the association of three DNA repair gene polymorphisms - Asn118Asn in ERCC1 (rs11615), Lys751Gln in ERCC2 (rs13181), and Asp1104His in ERCC5 (rs17655) - with the progression-free survival of 85 patients treated with platinum-based chemotherapy after surgery for NSCLC. (
  • Drug Resistance as a Biochemical Target in Cancer Chemotherapy covers the proceedings of the 13th Bristol-Myers Squibb Symposium on Cancer Research, entitled ''Drug Resistance as a Biochemical Target in Cancer Chemotherapy'', hosted by the Japanese Foundation for Cancer Research in Tokyo. (
  • This book is divided into four parts encompassing 18 chapters that summarize the results of both preclinical and clinical research on circumvention of drug resistance. (
  • The first two parts discuss the genetic aspects of multidrug resistance and the proteins involved in drug resistance. (
  • The third part describes the methods for detection of P-glycoprotein and its antagonists to counter clinical drug resistance. (
  • While previous studies had identified relapse-specific drug resistance mutations, the origin of those mutations was unclear. (
  • Additional research showed the mutations lead to multi-drug resistance. (
  • This group had the most relapse-specific mutations in the 12 drug-resistance genes, particularly compared to patients who relapsed earlier. (
  • This suggests drug resistance is not a foregone conclusion," Yang said. (
  • Based on the findings, Pui said screening relapsed patients for drug-resistance mutations may be indicated. (
  • Researchers at Roswell Park Cancer Institute (RPCI) have identified a mechanism of breast cancer cells that leads to chemotherapy resistance in inflammatory breast cancer. (
  • St. Jude Children's Research Hospital scientists have discovered how an aggressive tumor of the muscle and soft tissue hijacks an export pathway in cells to lay the groundwork for cancer progression and resistance to chemotherapy. (
  • In this study, St. Jude investigators identified a role for NEU1-regulated lysosomal exocytosis in cancer-drug resistance and tumor invasiveness, specifically in sarcomas that have spread. (
  • This is the first report that lysosomal exocytosis may play a role in drug resistance. (
  • Induction increases stress resistance critical for cell survival, because knockout of Nrf2 in mice increased susceptibility to a variety of toxicity and disease processes. (
  • The protective nature of Nrf2 could also be hijacked in a number of pathological conditions by means of somatic mutation, epigenetic alteration, and accumulation of disruptor proteins, promoting drug resistance in cancer and pathologic liver features in autophagy deficiency. (
  • Clinically relevant drug-resistant cell lines are developed by mimicking the conditions cancer patients experience during chemotherapy and cell lines display between two- and eight-fold resistance compared to their parental cell line. (
  • High-level laboratory models are developed with the aim of understanding potential mechanisms of resistance to chemotherapy agents. (
  • Heterogeneity in drug-resistant cell lines reflects the heterogeneity that can occur in clinical drug resistance. (
  • The development of chemotherapy drug-resistant cancer cell lines is a long established approach for investigating the mechanisms of cytotoxicity and resistance to chemotherapy agents. (
  • One of the first publications to describe the development of an anti-cancer drug-resistant in vitro model, which exhibited acquired resistance to a chemotherapy drug, was published in 1970 ( 1 ). (
  • Metabolic changes occurring in cancer cells are considered to be fundamental for the transformation of normal cells into cancer cells and are also responsible for the resistance to different types of chemotherapeutic drugs ( Cree, 2011 ). (
  • Among the different metabolic and signalling pathways that are altered in cancer cells, variations in the expression and activity of several drug- metabolizing enzymes play a critical role in drug resistance ( Rochat, 2009 ). (
  • Hypoxia also contributes to drug resistance because some chemotherapeutic drugs require oxygen to generate free radicals that contribute to toxicity. (
  • The proposal of this chapter is to describe the role of anticancer drug metabolism in chemotherapy resistance but also its importance for the development of new approaches, taking advantage of the specificity of cancer cells metabolism. (
  • While we know it involves a family of proteins called the 'Bcl-2 family' it is not well-understood how these proteins interact with each other to dictate the fate of a cell which interactions are important for cancer development and cancer drug resistance. (
  • These satellite DNA circles can contain drug resistance genes, which can protect the cancer cells from chemotherapy. (
  • Chemotherapy of malaria and resistance to antimalarial drugs in Guayana area, Venezuela. (
  • Resistance to antimalarial chemotherapy is one of the greatest difficulties for the control of malaria transmission. (
  • If a pilot study shows promising activity, the combination would need to be compared with standard chemotherapy in larger phase 2 and phase 3 trials involving many hundreds of patients. (
  • On Wednesday, researchers at Johns Hopkins University found that a genetic test can help predict how well people with a form of brain cancer will respond to standard chemotherapy drugs. (
  • Relapsed patients after a response to standard chemotherapy. (
  • Vincristine belongs in a class of drugs called vinca alkaloids. (
  • Short dental roots, delayed teeth, or missing teeth are more common in very young children who've had radiation to the brain and/or chemotherapy with a drug called vincristine. (
  • These parts also examine the structure, function, and expression of P-glycoproteins, with an emphasis on the role of these proteins as targets for cancer chemotherapy. (
  • DNA crosslinking also has useful merit in chemotherapy and targeting cancerous cells for apoptosis, [1] as well as in understanding how proteins interact with DNA. (
  • Scientists at Duke University Medical Center have found some compounds that improve a cell's ability to properly "fold" proteins and could lead to promising drugs for degenerative nerve diseases, including Huntington's disease, Alzheimer's disease and Parkinson's disease. (
  • Targeted therapy uses drugs to target specific molecules (for example, proteins) inside cancer cells or on their surface. (
  • Some targeted therapy drugs target specific proteins in cancer cells that aren't found in normal cells. (
  • Other targeted therapy drugs target mutated proteins or mutated genes in cancer cells. (
  • Immunoelectron microscopy analysis detected chitinase in the pharyngeal glands of O. volvulus , structures that may contain a wide variety of proteins essential for the remodeling processes during molting and the shedding of the old cuticle. (
  • The general idea behind modern antiviral drug design is to identify viral proteins, or parts of proteins, that can be disabled. (
  • During the course of this study, blood and bone marrow samples will be obtained to measure levels of the chemotherapy drugs as well as levels of certain enzymes (proteins). (
  • This is becoming an increasingly important issue as new drugs have been developed that can specifically target the Bcl-2 proteins within cells. (
  • They hoped that studying these images would provide them with an understanding of exactly why these proteins could make some chemotherapies fail. (
  • Blocking CDKs (a family of proteins responsible for pRB inactivation) activity is the mechanism of action of new anti-cancer drugs when used with conventional drugs in clinical trials. (
  • Interaction with other proteins to influence cell survival, apoptosis, and the process by which cells mature to carry out special functions (differentiation). (
  • There is some proof that that there is a difference between males and females in how well chemotherapy works for these cancers. (
  • Mitomycin C (MMC) is from a class of antibiotics that are used broadly in chemotherapy, often with gastrointestinal related cancers. (
  • Moreover, the experiments suggest the combination might extend the use of platinum drugs to other cancers where they haven't previously been shown to be effective. (
  • Surgery and Chemotherapy The most recent strategy is surgery combined with chemotherapy, which stimulates cancers to spread though the blood to additional organs. (
  • Like cryosurgery, topical chemotherapy it is used to treat actinic keratosis and superficial skin cancers. (
  • Radiation therapy is commonly used to treat head and neck cancers, alone or in combination with chemotherapy and/or surgery. (
  • Whilst these drugs have now been approved for use in patients with certain cancers and have been shown to be extremely effective, other types of cancers show little or no response because the drugs fail to induce appoptosis of the cancer cells. (
  • This is the human protein which is believed to play a key role in causing chemotherapy failure in a number of recurring cancers. (
  • Some blood cancers are treated effectively with a single drug. (
  • This part also considers the alternative clinical approaches against drug failure, including non-crosss-resistant therapies, autologous bone marrow transplantation, dose-intensive therapy, and high-dose chemotherapy. (
  • Most people will receive chemotherapy in a clinical setting, but sometimes a person can take it at home. (
  • In many patients, the clinical manifestation of heart failure may not appear until a year, or several years, after completion of chemotherapy. (
  • Mobile will continue to revolutionize every step of the clinical trial process, and we will continue to innovate in this space to deliver our clients and their patients the tools they need to succeed, today and in the future. (
  • Adverse health effects among nurses and clinical pharmacists handling antineoplastic drugs: adherence to exposure control methods. (
  • To test these enzyme candidates, Gloeckner, Janda and their colleagues used the Johns Hopkins clinical compound library-which contains 1,514 compounds, of which 1,082 are U.S. Food and Drug Administration (FDA)-approved drugs and 432 are foreign-approved drugs-to screen for active compounds. (
  • And perhaps most importantly, the researchers showed that such bone loss can be stopped by treating the mice with either of two investigational drugs already being evaluated in clinical trials. (
  • In a recent study published in the scientific journal Translational Oncology , researchers from the Federal University of Rio de Janeiro (UFRJ), State University of West Zone, (UEZO) and D'Or Institute for Research and Education (IDOR) tested the therapeutic effect of a combination of conventional - common anti-cancer agents - and new drugs - under clinical trials. (
  • Relative to DOX toxicity, research involving animals has also shown that exercise protects against deleterious heart dysfunction while showing an enhancement of potential mechanisms involved in chemotherapy induced heart failure (i.e. anti-oxidant and anti-apoptosis pathways). (
  • Induction of massive apoptosis of hair follicle cells by chemotherapy has been implicated in the pathogenesis of chemotherapy-induced alopecia (CIA), but the underlying mechanisms of regulation are not well understood. (
  • The new compound fights cancer by triggering apoptosis, the process that rids the body of unwanted or malfunctioning cells. (
  • Some chemotherapy drugs kill cancer cells by indirectly inducing apoptosis by damaging DNA. (
  • This process is known as apoptosis and is essential for us to remain health. (
  • Indeed, our studies have already provided important advances in our understanding of one of the main processes (apoptosis) that often becomes defective in cancer cells. (
  • Apoptosis is the process of programmed cell death in multicellular organisms. (
  • See the section High-dose Chemotherapy and Stem Cell Transplant . (
  • High-dose chemotherapy with autologous hematopoietic stem cell transplant is still an essential step of the standard care for selected types of cancer in children at high risk of relapse with conventional chemotherapy. (
  • There are researches going on to develop the smart drugs which can precisely target the cancerous cells. (
  • With the drugs the doctors can kill the cancerous cells as these drugs adjust the hormone levels. (
  • Blood vessels in the tumor, however, have porous walls, so that the nanoparticles containing the chemotherapy can work their way into the cancerous cells. (
  • Chemotherapy drug that stops cancerous cells from dividing by cross-linking DNA strands. (
  • Small molecule targeted cancer therapies are drugs designed to block the growth of cancerous cells. (
  • In this case, your doctor may prescribe different drugs to target and kill the cancerous cells. (
  • The ability to measure scattering is essential to evaluating the efficacy of drugs that may inhibit or reverse EMT because it gives researchers a reliable way to compare the effects of one drug against another. (
  • Some researchers proposed that ALL relapse was driven by drug-resistant leukemic cells present at diagnosis. (
  • Researchers identified relapse-specific acquired mutations in 12 genes involved in drug response, including FPGS , a novel, relapse-related gene. (
  • Despite this setback, and because rosizitaglone was well-tolerated by patients compared to standard cancer drugs, Dana-Farber researchers believed it was worthwhile to try it and similar PPAR-gamma ligands in a different context, said Geoffrey Girnun, PhD, a researcher in Spiegelman's laboratory and lead author of the Cancer Cell report. (
  • After discussing it with other Dana-Farber researchers, we decided to try these agents in combination with platinum-based drugs, and in several different cell lines, we saw positive results," said Girnun. (
  • Phan and colleagues examined alcohol's effects on connectivity between the amygdala and the prefrontal cortex during the processing of emotional stimuli - photographs of happy, fearful and angry faces - using functional magnetic resonance imaging, or fMRI, an imaging technique that allows researchers to see which areas of the brain are active during the performance of various tasks. (
  • A drug developed at the University of Kansas has the potential to stop a debilitating condition of diabetes that often leads to pain in the extremities and even amputations, KU researchers have found. (
  • This is the main conclusion of Spanish researchers coordinated by Doctors Maria -ngeles Mena and Justo Garc-a de Y-benes, from CIBERNED (Centro de Investigaci-n Biom-dica en Red de Enfermedades Neurodegenerativas). (
  • These are no longer the only options as researchers continue to develop new drugs. (
  • The researchers further found that this process occurs in males and females and is independent of cancer type. (
  • Researchers presented the findings Thursday at a Symposium on New Drugs in Cancer Therapy in Amsterdam. (
  • The UC Davis researchers further showed that the process of "ultrasound-induced mild hyperthermia" can be used to enhance the build-up at the tumor site of tiny nanoparticles. (
  • The emergence of antivirals is the product of a greatly expanded knowledge of the genetic and molecular function of organisms, allowing biomedical researchers to understand the structure and function of viruses, major advances in the techniques for finding new drugs, and the pressure placed on the medical profession to deal with the human immunodeficiency virus (HIV), the cause of acquired immunodeficiency syndrome (AIDS). (
  • Researchers working on such "rational drug design" strategies for developing antivirals have tried to attack viruses at every stage of their life cycles. (
  • Researchers undertook many laboratory experiments before conducting their tests with mice -- which were the first actual tests using this delivery method for chemotherapy. (
  • In another study in the same issue of the journal, researchers reported that women with breast cancer getting chemotherapy and tamoxifen had reduced risk of getting cancer in the healthy breast. (
  • Researchers are now able to use a 3D computer model which helps them to screen millions of chemo drugs. (
  • This brand new approach has been able to give researchers a fully movable view of the structure of a protein that is believed played a crucial role in chemotherapy failure. (
  • Unfortunately, even with this amazing computing power at hand, the odds are still stacked against any medical researchers trying to identify a drug compound that will actually work. (
  • Chemotherapy uses drugs that kill dividing cancer cells and prevent them from growing. (
  • This is because the drugs often target both cancer cells and healthy cells. (
  • The drugs were also tested individually and together on ovarian cancer cell lines that normally are resistant to chemoth erapy -- and proved capable of reducing growth of the cancer cells by 90 percent. (
  • Even when applied to colon cancer cells, a type of cancer not usually treated with platinum drugs, rosiglitazone and carboplatin lowered the growth rate by 70 percent. (
  • Chemotherapy Chemotherapy works by damaging and killing cancer cells. (
  • It impedes the growth process that is specific to cancer cells. (
  • Kinase inhibitors are drugs that stop kinases within cancer cells. (
  • Drug-resistant cell models are developed in the laboratory by repeatedly exposing cancer cells growing in cell culture to drugs. (
  • Moreover, hypoxia might modulate expression of enzymes directly involved in metabolism of chemotherapeutic drugs, thereby limiting the toxic effects of these drugs on cancer cells. (
  • Anticancer or chemotherapy drugs are powerful chemicals that kill cancer cells by arresting their growth at one or more checkpoints in their cell cycle. (
  • By targeting these molecules, the drugs block their signals and stop the growth and spread of cancer cells while harming normal cells as little as possible. (
  • Monoclonal antibodies can also help chemotherapy and radiation get into cancer cells and destroy them. (
  • Chemotherapy drugs work by killing fast-growing cells, such as cancer cells. (
  • Chemotherapy is the use of drugs to kill cancer cells. (
  • The drugs kill mostly cancer cells. (
  • Many advances have been made (and are still underway) in chemotherapy over the years, and more and more drugs are becoming available to target specific kinds of cancer cells and to minimize side effects. (
  • So chemo drugs are designed to target cancer cells by destroying rapidly dividing cells. (
  • This can be a result of the drugs breaking down cancer cells and other rapidly diving cells in the body. (
  • Cancer cells tend to form new cells more quickly than normal cells and this makes them a better target for chemotherapy drugs. (
  • However, chemo drugs can't tell the difference between healthy cells and cancer cells. (
  • Chemo drugs attack cells that are dividing quickly, which is why they work against cancer cells. (
  • That means that cancer cells that are far from the blood vessels that supply the tumour do not get the chemotherapy drugs. (
  • In addition, these defects make cancer cells difficult to kill using approaches such as chemotherapy. (
  • Peggy Howe, 52, said she began taking Escozine, a dietary supplement not yet approved by the Food and Drug Administration, in February 2011 after being told she had two months to live because the cancer cells in her body were growing rapidly and had spread to her liver and lungs. (
  • A type of chemotherapy used to kill cancer cells by interfering with cancer cell division. (
  • Radiation -This process utilizes high-energy beams to kill off remaining cancer cells following surgery while preventing them from growing and spreading. (
  • However, many conventional and investigational drug therapies combine drugs that attack cancer cells at different points in their growth cycles. (
  • This approach often makes therapy more effective and reduces the chance that the cancer cells will become resistant to a particular drug. (
  • Sometimes cancer cells may be resistant to the initial drugs used or can become resistant to the drugs after a period. (
  • Antimitotics damage cancer cells by blocking a process called mitosis (cell division), which prevents cancer cells from dividing and multiplying. (
  • This process sometimes speeds up in cancer cells. (
  • Heated intraperitoneal chemotherapy (HIPEC) involves circulating heated chemotherapy drugs throughout the abdominal cavity. (
  • That's the conclusion of a wide-ranging analysis that pooled the results of eight randomized trials that compared the drugs with non-anthracyclines and took into account the women's HER2 status. (
  • To learn more about anthracyclines and other chemotherapy drugs, visit the American Cancer Society . (
  • Nineteen of them had the altered form of the gene, and 12 of the 19 had significant responses to chemotherapy. (
  • In our project we use a unique set of reagents we have developed to establish which members of the Bcl-2 family are critical in cancer development and which interactions are most important for determining responses to chemotherapy and other drugs. (
  • In general, exercise has many pleiotropic effects for patients receiving chemotherapy (e.g. reduces fatigue, improves endurance, reduces frailty, and enhances quality of life). (
  • Women in their 30's are capable of tolerating much higher doses of chemotherapy without experiencing menopause, either temporarily or permanently, than women in their 40's or older. (
  • It uses high doses of chemotherapy and sometimes radiation to "turn off" a patient's immune system so that the donor cells are not rejected. (
  • If the disease is not responsive, 2 more courses of chemotherapy are given. (
  • In the placebo group, the QOL functional well‑being score was lower on day 8 after both the first and second courses of chemotherapy compared with the baseline score, but it had not decreased in the LEM group. (
  • Substances that work to help blood generating tissues recover from the effects of radiation or chemotherapy. (
  • However, in addition to drug side-effects (e.g. dizziness/lightheadedness), they do not target the underlying mechanism of chemotherapy induced cardiotoxicity. (
  • Then the financial burden and timeliness of bringing about novel cancer fighting compounds hinders progress of finding alternatives to chemotherapy. (
  • Preparation and administration of chemotherapy: Haematological consequences for hospital-based nurses. (
  • The drugs enter the bloodstream and travel through the body. (
  • These drugs enter the bloodstream and reach throughout the body. (
  • Instead of being injected straight into the bloodstream and transported randomly to both sick and healthy cells, the chemotherapy medicine is encapsulated in nanoparticles. (
  • When nanoparticles containing the cancer drugs are injected into the bloodstream, the nanoparticles are so large that they remain in the blood vessels in most types of healthy tissues. (
  • The bubbles that contain the chemotherapy-laden nanoparticles are injected into the bloodstream. (
  • The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective or appropriate for any given patient. (
  • A single drug or combination of drugs can do this. (
  • PURPOSE: Randomized phase III trial to compare the effectiveness of combination chemotherapy with or without dexrazoxane in treating children who have Hodgkin's disease. (
  • Hypothesis Combination of oral curcumin with FOLFOX-based chemotherapy will be a safe and tolerated regimen for long-term administration to patients with colorectal metastases. (
  • Generally, the net renal excretion is considered to be a combination of three major processes, namely glomerular filtration, tubular secretion, and tubular reabsorption. (
  • Chemotherapy drugs are used in combination and may also be given with other types of medications, like immunomodulating agents. (
  • A lymphoma patient may take only a single drug or undergo a regimen involving a combination of drugs. (
  • A 2016 Wayne State University study found patients given a chemo drug combination lived three times longer than patients without it. (
  • On the other hand, "wrong" combination of drugs could elicit harmful effects," states Helena Borges, professor at Institute of Biomedical Sciences of UFRJ, and study leader. (
  • Tailor therapy based on rapidity of response in order to minimize cumulative drug dosages. (
  • Exercise, in various forms, has shown promise in animal studies as a potential cardio-protective therapy to counteract drug toxicity. (
  • Thrombolytic therapy is the use of drugs that dissolve blood clots. (
  • Thrombolytic therapy uses drugs called thrombolytic agents, such as alteplase (Activase), anistreplase (Eminase), streptokinase (Streptase, Kabikinase), urokinase (Abbokinase), and tissue plasminogen activator (TPA) to dissolve clots. (
  • This study points to the potential need to individualize therapy when drug-resistant mutations emerge in ALL", said co-corresponding author Jun J. Yang , Ph.D., of the St. Jude Departments of Oncology and Pharmaceutical Sciences. (
  • This study helps to answer a central question of cancer biology, which is how tumor cells become invasive and drug resistant," said corresponding author Alessandra d'Azzo, Ph.D., who holds the Jewelers For Children Endowed Chair in Genetics and Gene Therapy and is a member of the St. Jude Department of Genetics. (
  • Targeted therapy Targeted therapy is a class of drugs. (
  • There are different types of targeted therapy drugs. (
  • Targeted therapy only works if a cancer cell has the gene or protein target that the drug is trying to block. (
  • Small-molecule drugs describes many of the other types of targeted therapy drugs that are not monoclonal antibodies. (
  • Targeted therapy drugs are also grouped by what protein they are targeting or how they work. (
  • Some targeted therapy drugs belong to more than one grouping. (
  • They do this by locking on to a protein on the cell's surface, and the chemotherapy or radiation therapy is then taken up (absorbed) by the cancer cell. (
  • While breast cancer gives successful results when treated with the hormone therapy, the prostate cancer also shows signs of improvement with the new drugs. (
  • Univariate analyses revealed that the independent factors influencing survival prognoses included Karnofsky Performance Status score, control of the primary lung tumor, interval between the confirmed diagnoses of lung cancer and BM, presence of extracranial metastasis, number of chemotherapy cycles undergone, Graded Prognostic Assessment class, administration of combined targeted drug therapy, the pathological type, and the cultural backgrounds of the patients. (
  • Multivariate analyses indicated that the number of chemotherapy cycles, administration of combined drug therapy, and patients' cultural background were key independent factors influencing survival prognoses. (
  • Chemotherapy combined with targeted drug therapy could increase the patients' median and overall survival rates. (
  • The number of chemotherapy cycles undergone, administration of combined targeted drug therapy, and the cultural backgrounds of the patients had significant effects on the patients' survival prognoses. (
  • In these cases, post-surgery radiation therapy may be used alone or, more commonly today, combined with chemotherapy. (
  • Various natural supplements have shown some promise for improving the effectiveness of conventional cancer therapy (specifically, surgery, chemotherapy, and radiation ) or reducing its side effects. (
  • Current HCC therapy options include surgery, biotherapy, and chemotherapy. (
  • Now, while I like the idea of computationally repurposing drugs, I should note that digoxin had also already been discovered in 2011 as a possible prostate cancer therapy by a more traditional screen-all-the-drugs study. (
  • Along with systemic chemotherapy, one of the drugs (carboplatin) may be injected in the tissues around the eye, where it slowly diffuses into the eyeball. (
  • The drug used most often is melphalan, but other drugs such as carboplatin and topotecan can also be used. (
  • Less common HIPEC drugs include oxaliplatin, carboplatin and irinotecan. (
  • Amicus Therapeutics announced today additional positive preliminary data from its ongoing Phase 2 extension study of its investigational drug Amigal™ (migalastat HCl) for Fabry disease at the Lysosomal Disease Network WORLD Symposium in Miami, Florida. (
  • The investigational drugs, a p38MAPK inhibitor and a MK2 inhibitor, block different parts of the same pathway leading to bone loss. (
  • She came to Memorial Sloan Kettering where she received 12 weeks of an investigational chemotherapy drug. (
  • The results were very exciting because the successful outcome depended on the chemotherapy regimens. (
  • Zensana (ondansetron hydrochloride) is an oral spray 5-HT3 antagonist formulation intended for the prevention of chemotherapy induced nausea and vomiting. (
  • In gastrointestinal cancer patients undergoing chemotherapy, oral LEM exerted an inhibitory effect on the incidence of adverse events (AEs), such as chemotherapy-induced nausea, and also improved immune function, by increasing natural killer (NK) cell activity, resulting in improvement of the patients' QOL ( 20 , 21 ). (
  • Corticosteroids can also help to treat the symptoms of chemotherapy, like nausea and vomiting. (
  • Why does chemotherapy cause side effects like hair loss, nausea, tiredness and libido changes? (
  • His protocol called for several different chemo drugs to be administered intrav … enously. (
  • He also takes two types of chemo drugs in a pill form. (
  • Chemo drugs can be grouped by how they work, their chemical structure, and their relationships to other drugs. (
  • In most cases, chemo drugs are injected into a vein (IV) or given by mouth. (
  • Because the chemo is put directly into the artery feeding the eye, doctors can use much smaller doses of chemo drugs (less than 10% of the doses used for systemic chemo). (
  • A healthy body constantly replaces cells through a process of dividing and growing. (
  • RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. (
  • Until recently, measuring how a drug affected one aspect of EMT, cell scattering, was a manual process that involved subjectively assessing the relative closeness of cells in a culture. (
  • Based on MATLAB ® , Image Processing Toolbox ™ , and Statistics and Machine Learning Toolbox ™ , the system measures nucleus-to-nucleus distances of nearest-neighbor cells. (
  • To quantify the scattering of the cells, we developed a numerical procedure that uses image processing and statistical analyses. (
  • Mathematical modeling, mutational analysis and other evidence indicated that earlier relapse was likely caused by drug-resistant tumor cells present at diagnosis. (
  • The now drug-resistant cells divide and eventually cause relapse. (
  • Loss of NEU1 disrupts the process, leading to the uncontrolled discharge of harmful lysosomal contents into the cells' microenvironment, severely affecting tissue and organ function. (
  • That raised the question of whether the same process helps tumor cells invade surrounding tissue and become metastatic. (
  • Chemotherapy is when a toxin is instead injected directly into the patient, believing that it will only kill the cancer (and weaker) cells. (
  • It harms normal cells less than chemotherapy. (
  • maintaining cells with chemotherapy, pulse treating with chemotherapy, or returning to master drug-resistant stocks. (
  • A Jackson Laboratory research team led by Professor Patsy Nishina, Ph.D., has identified a mutation in a gene that's essential for correct protein-processing in cells. (
  • Chemotherapy and radiation both work by killing fast-growing cells. (
  • Small-molecule drugs pass through cells easily. (
  • Some healthy cells may be killed in the process. (
  • Interferon may be used with chemotherapy to help prolong remission, slowing the speed at which myeloma cells grow. (
  • Chemotherapy drugs are engineered to attack cells that divide rapidly. (
  • Cells in the hair follicles, gut and immune system are all affected by chemotherapy. (
  • Chemotherapy drugs target cells at different phases of the process of forming new cells, called the cell cycle. (
  • Because these drugs damage DNA, they can affect the cells of the bone marrow which make new blood cells. (
  • Designing safe and effective antiviral drugs is difficult because viruses use the host's cells to replicate. (
  • This makes it difficult to find targets for the drug that would interfere with the virus without also harming the host organism's cells. (
  • I'm working on figuring out how we can deliver more of the chemotherapy drugs to the tumor and less to healthy cells," says Sofie Snipstad, who recently graduated from the Department of Physics at the Norwegian University of Science and Technology (NTNU). (
  • This prevents the chemotherapy from harming healthy cells. (
  • However, the nanoparticles can only reach cells that are closest to the blood vessels that carry the drug-laden particles, she said. (
  • The stem cells are collected by a process called leukapheresis. (
  • After the subject receive the chemotherapy drugs mentioned above, the stem cells will be thawed and given like a blood transfusion. (
  • Class of chemotherapy drugs that work to stop tumor growth by cross-linking guanine nucleobases making cells unable to divide. (
  • To better understand the relationship between gene amplification, environmental stress and the aging process, scientists at Babraham Institute in Britain turned to yeast cells, an ideal model for epigenetics research. (
  • Overall, 12 of the top 100 drugs predicted by this method showed marked effects on medulloblastoma-derived cells in culture, which is far over what you'd expect by chance (and better than some previous efforts in this area). (
  • Bone loss that can lead to osteoporosis and fractures is a major problem for cancer patients who receive chemotherapy and radiation. (
  • Cancer patients who receive chemotherapy and radiation lose a lot more bone than women with breast cancer treated with aromatase inhibitors, which eliminate estrogen. (
  • Since modern systemic chemotherapy is well advanced, the role of intra-arterial infusion chemotherapy is not much recognized in the field of medical oncology. (
  • This is known as systemic chemotherapy . (
  • A newer approach sometimes used instead of systemic chemotherapy is to inject chemo directly into the ophthalmic artery, the main artery that supplies blood to the eye. (
  • Diagnostic procedures, such as MRI, may help doctors predict whether patients will have heart damage caused by chemotherapy in patients with cancer receiving chemotherapy. (
  • Understanding how these drugs work helps doctors predict which drugs are likely to work well together. (
  • Doctors can also plan how often doses of each drug should be given based on the timing of the cell phases. (
  • This helps doctors decide which drugs are likely to work well together. (
  • The study doctors will be measuring how well the disease responds to the drugs as well as any side effects to the drugs. (
  • Doctors may recommend chemotherapy to mesothelioma patients deemed ineligible for surgery. (
  • Diabetes Drug Dramatically Boosts Potency of Platinum Chemotherapy ( A widely used diabetes drug dramaticall. (
  • Combining a platinum chemotherapy agent and the diabetes drug rosig. (
  • We really see a way forward here to improve the chemotherapy's effectiveness for multiple forms of cancer," said George Demetri, MD, a Dana-Farber researcher who is preparing a proposal for a pilot study of rosizitaglone and platinum chemotherapy drugs in lung and ovarian cancer and sarcomas. (
  • Most targeted therapies are either monoclonal antibodies or small-molecule drugs. (
  • An improved understanding of the eccDNA formation process could help scientists design more effective cancer-targeting drug therapies. (
  • Proper studies require money and patience with the scientific process, and proponents of alternative cancer therapies may lack one or both of those. (
  • We also discuss natural options that may reduce side effects of standard cancer therapies, as well as possible interactions between herbs and supplements and drugs. (
  • We offer a comprehensive array of home infusion therapies from antibiotics and parenteral nutrition to chemotherapy and pain management. (
  • Our dedicated pharmacists monitor patient drug therapies, then review medication profiles, laboratory results and nursing reports. (
  • Nevertheless, these results indicate the conventional pig could be an appropriate animal model to study renal drug elimination processes in humans. (
  • Topotecan will be given with melphalan, another chemotherapy drug. (
  • We think this (gene) will define a new class of anti-cancer compounds, which are selective for specific types of cancer and will have less toxicity than traditional cancer drug (genes),' said Dr. Jack Singer, research program chairman at Cell Therapeutics . (
  • Immunohistochemical expression of the excision repair cross-complementation group (ERCC)-1 protein has been associated with response to platinum-based chemotherapy in patients with NSCLC, and some polymorphisms of the genes involved in DNA repair have been shown to be associated with survival in advanced NSCLC. (
  • As a result, there is increased interest in developing cancer drugs that target EMT in addition to drugs that target cell proliferation and survival. (
  • The research study is titled "Ultrasound ablation enhances drug accumulation and survival in mammary carcinoma models. (
  • Chemotherapy also helps extend survival rates. (
  • If you have chemotherapy your doctor usually works out the dose using your weight and height. (
  • Predisposition to hair loss, drug type and drug dose can all affect whether someone loses their hair during chemotherapy. (
  • The risk of leukemia from alkylating agents is "dose-dependent," meaning that the risk is small with lower doses, but goes up as the total amount of the drug used gets higher. (
  • For this reason, lifetime dose limits are often placed on these drugs. (
  • The purpose of this research study is to determine the safest dose of topotecan (a chemotherapy drug) when given in a high dose before a stem cell transplant. (
  • Ongoing development of a one-dose transplant drug to prevent organ rejection. (
  • It carries drugs across the cell membrane and delivers drugs precisely at its cellular target site with 1/10th dose. (
  • Chemotherapy agents usually have a narrow therapeutic window, allowing for very little blood-concentration variation before causing increased adverse effects or altering anticancer efficacy. (
  • normally antineoplastic drugs attempt to slow down DNA synthesis, not provide … extra raw materials for it. (
  • Krstev S, Perunicic B and Vidakovic A. Work practice and some adverse health effects in nurses handling antineoplastic drugs. (
  • Kusnetz E and Condon M. Acute effects from occupational exposure to antineoplastic drugs in a para-professional health care worker. (
  • Stücker I, Caillard J-F, Collin R, Gout M, Poyen D and Hémon D. Risk of spontaneous abortion among nurses handling antineoplastic drugs. (
  • however, many patients do still require intravenous chemotherapy before or after surgery. (
  • A complete drug-induced absence of sensation and consciousness induced by an anesthesiologist during surgery. (
  • Within a couple of months, the cancer returned, and she had surgery to remove underarm lymph nodes and again underwent chemotherapy. (
  • Combined with surgery, the entire process takes 8 - 14 hours, on average. (
  • One strategy to inhibit tumor cell repopulation is the use of cytostatic compounds between courses of lethal chemotherapy. (
  • Two new drug compounds - one of which has already proven useful in a mouse model of multiple sclerosis - appear to be effective in treating endometriosis, a disorder that, like MS, is driven by estrogen and inflammation, scientists report in Science Translational Medicine. (
  • The Alzheimer's Drug Discovery Foundation announced today that it has awarded a grant of $210,300 to Amicus Therapeutics (Cranbury, NJ) to evaluate small-molecule, orally delivered pharmacological chaperone compounds as a novel approach for treating Alzheimer's disease. (
  • Therapeutic equivalence exists when two drug compounds are scientifically shown to have equal effects. (
  • These SMU biochemists are using this 3D model to effectively screen more than 8 million potential drug compounds in the hopes that there will be at least one which can prevent this failure. (
  • The biochemists have shown that running these drug compounds through the computational model serves as an effective way to rapidly screen immense numbers of compounds. (
  • A widely used diabetes drug dramatically boosted the potency of platin. (
  • Thus, proapoptotic chemotherapeutic agents stimulate the caspase-8-mediated processing and release of IL-1β, implicating direct effects of such drugs on a noncanonical inflammatory cascade that may modulate immune responses in tumor microenvironments. (
  • Chemotherapy suppresses the immune system and creates greater acidosis, which is likely to stimulate even more cancer. (
  • Immunomodulators Immunomodulators are drugs that modify some parts of the immune system. (
  • Lassila O, Toivanen A and Nordman E. Immune function in nurses handling cytostatic drugs. (
  • Anthracycline-based chemotherapies for breast cancer are known to adversely affect patients' quality of life (QOL) and immune function. (
  • Oral LEM that was coadministered with anthracycline‑based chemotherapies was useful for maintaining patients' QOL and immune function. (
  • Moreover, although the host immune function of breast cancer patients on chemotherapy affects the recurrence rate ( 12 ), anthracycline-based chemotherapy is reported to adversely affect immune function ( 13 ). (
  • The process also seems to stimulate the local immune response. (
  • JAK inhibitors block the enzymes JAK1, JAK2, JAK3 and tyrosine kinase 2, which play a role in the cell-signaling process that leads to the inflammatory and immune responses seen in certain diseases. (
  • The canonical cleavage and processing of proIL-1β into mature IL-1β cytokine (17 kDa) are catalyzed by caspase-1, a pathway regulated by multiprotein inflammasome signaling complexes. (
  • Working in the laboratory, investigators also demonstrated in principle that medication can be used to help restrain the pathway, blocking cancer's spread and restoring tumor vulnerability to chemotherapy. (
  • Women may become menopausal as a result of certain chemotherapy medications, and experience symptoms associated with menopause such as hot flashes, vaginal dryness, and painful intercourse. (
  • It outlines the effects of enterohepatic recirculation, differentiates between drug actions and effects, and describes differences in absorption rates of different types of oral medications. (
  • In addition to receiving the chemotherapy drug Herceptin, Howe takes two medications to counter heart damage caused by the chemotherapy, a thyroid medication and an antidepressant. (
  • DDIs are a growing concern in cancer patients receiving chronic chemotherapy agents in addition to medications for other conditions. (
  • Our team has received specialty training in the process of infusion, and are educated with knowledge of an array of specialty medications. (
  • HIPEC is also referred to as chemoperfusion and hyperthermic chemotherapy. (
  • Chemotherapy can cause ovarian damage or failure. (
  • Methotrexate and cytarabine belong to a class of drugs called antimetabolites. (
  • Bisphosphonates are given to slow the process of bone loss. (
  • They have shown that radiation and chemotherapy can halt cell division in bone, which results in a stress response referred to as senescence. (
  • Some thrombolytic agents may not work properly in people who have just had a strep infection, so the physician may want to use a different drug. (
  • Both drugs work by activating PPAR-gamma, a transcription factor that functions as a master regulator of fat development in the body, a function discovered in the Spiegelman lab in 1994. (
  • They each work differently depending on what molecule (gene or protein) the drug is targeting. (
  • Some drugs work in more than one way, and may belong to more than one group. (
  • How Does Heated Chemotherapy Wash Work? (
  • The dynamic synthesis and degradation of chitin by these enzymes is a prerequisite for the organism's development and therefore a potential drug target. (
  • The molting process is considered a potential new target for chemotherapy against onchocerciasis," Gloeckner explains. (
  • Furthermore, the European and Asian-Pacific regions are expected to witness increased market traction due to commercialization of target oriented economic drugs. (
  • Coupling this with the profiles of the known drugs suggested possibilities for useful off-target effects. (
  • To test the ability of the pre- to post-anthracycline-based chemotherapy (Anth-bC) changes in our MRI platform generated measures of LV function to predict pre- to 24 month post-Anth-bC differences in LV function. (
  • To determine if pre- to 3 month post-anthracycline-based chemotherapy (Anth-bC) changes in our MRI platform generated measures of LV volumes, EF, strain, myocardial T1, and aortic PWV predict pre- to 24 month post-Anth-bC differences in these same parameters. (
  • Thus, LEM appears to be a useful oral adjuvant for patients receiving anthracycline‑based chemotherapy. (
  • However, patients on anthracycline-based chemotherapy experience fatigue and a decrease in their activity and daily quality of life (QOL), and these problems may be difficult to control ( 9 - 11 ). (
  • It is a member of the Anthracycline class of drugs . (
  • The new research shows that clostanel has the potential to inhibit the molting process of the parasite that causes the disease. (
  • A few drugs inhibit the process of cell division. (