A form of ischemia-reperfusion injury occurring in the early period following transplantation. Significant pathophysiological changes in MITOCHONDRIA are the main cause of the dysfunction. It is most often seen in the transplanted lung, liver, or kidney and can lead to GRAFT REJECTION.
The transference of either one or both of the lungs from one human or animal to another.
A fibrillar collagen found widely distributed as a minor component in tissues that contain COLLAGEN TYPE I and COLLAGEN TYPE III. It is a heterotrimeric molecule composed of alpha1(V), alpha2(V) and alpha3(V) subunits. Several forms of collagen type V exist depending upon the composition of the subunits that form the trimer.
Individuals supplying living tissue, organs, cells, blood or blood components for transfer or transplantation to histocompatible recipients.
Inflammation of the BRONCHIOLES leading to an obstructive lung disease. Bronchioles are characterized by fibrous granulation tissue with bronchial exudates in the lumens. Clinical features include a nonproductive cough and DYSPNEA.
The survival of a graft in a host, the factors responsible for the survival and the changes occurring within the graft during growth in the host.
An immune response with both cellular and humoral components, directed against an allogeneic transplant, whose tissue antigens are not compatible with those of the recipient.
Elements of limited time intervals, contributing to particular results or situations.
Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.
The transference of a kidney from one human or animal to another.
Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.
The transference of a part of or an entire liver from one human or animal to another.
General dysfunction of an organ occurring immediately following its transplantation. The term most frequently refers to renal dysfunction following KIDNEY TRANSPLANTATION.

Association between primary graft dysfunction among lung, kidney and heart recipients from the same multiorgan donor. (1/98)

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Impact of human donor lung gene expression profiles on survival after lung transplantation: a case-control study. (2/98)

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Late primary graft dysfunction after lung transplantation and bronchiolitis obliterans syndrome. (3/98)

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Plasma cytokines and chemokines in primary graft dysfunction post-lung transplantation. (4/98)

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Participation of autophagy in the initiation of graft dysfunction after rat liver transplantation. (5/98)

Better ways to prevent the cold ischemia-warm reperfusion (CI/WR) injury associated with liver transplantation are needed, and many investigations have focused on the molecular mechanisms of this injury. However, the mechanisms reported to date are controversial and no improvement in therapy has resulted. Here, using prolonged CI and orthotopic transplantation of rat liver grafts, we found that the CI/WR injury was closely associated with autophagy. By 15 minutes after the start of WR, small masses of hepatocytes that possessed abundant autophagosomes and autolysosomes frequently dissociated from the hepatic cords and obstructed the sinusoid, causing massive necrosis of hepatocytes within 2 hours. The cell masses included TUNEL-positive nuclei without caspase-3 and -7 activation. Autophagy suppression with the phosphatidylinositol 3-kinase (PI3K) inhibitors, wortmannin or LY294002, reduced both liver damage and the mortality rate of recipient rats. To elucidate the downstream mechanisms of this autophagic pathway, liver grafts were treated with aspartic and cysteine proteinase inhibitors, pepstatin and leupeptin. This treatment also significantly improved the survival rate of recipient rats. These data suggest that autophagy-associated hepatocyte death triggers liver graft dysfunction. The protective effects of suppressing autophagy may suggest new ways to prevent CI/WR injury of the liver.  (+info)

Does anaesthetic management affect early outcomes after lung transplant? An exploratory analysis. (6/98)

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Concurrent Kaposi's sarcoma, tuberculosis, and allograft dysfunction in a renal transplant patient. (7/98)

The major long-term complications of renal transplantation (RT) include cardio-vascular disease, opportunistic infections, malignancies, and chronic allograft nephropathy. Long-term complications are generally considered as those occurring more than 1 year post trans-plantation; however, some of the complications can occur earlier. We present a 58-year-old man who presented with multiple complications of RT concurrently and relatively early post trans-plantation including Kaposi's sarcoma, tuberculosis and allograft dysfunction.  (+info)

Soluble p-selectin and the risk of primary graft dysfunction after lung transplantation. (8/98)

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Primary graft dysfunction (PGD) is a severe complication that can occur after an organ transplant, such as a lung or heart transplant. It refers to the early functional impairment of the grafted organ that is not due to surgical complications, rejection, or recurrence of the original disease.

In the case of lung transplants, PGD is defined as the evidence of poor oxygenation and stiffness in the lungs within the first 72 hours after the transplant. It is typically caused by inflammation, injury to the blood vessels, or other damage to the lung tissue during the transplant procedure or due to pre-existing conditions in the donor organ.

PGD can lead to serious complications, including respiratory failure, and is associated with increased morbidity and mortality after transplantation. Treatment may include supportive care, such as mechanical ventilation and medications to support lung function, as well as strategies to reduce inflammation and prevent further damage to the grafted organ.

Lung transplantation is a surgical procedure where one or both diseased lungs are removed and replaced with healthy lungs from a deceased donor. It is typically considered as a treatment option for patients with end-stage lung diseases, such as chronic obstructive pulmonary disease (COPD), cystic fibrosis, idiopathic pulmonary fibrosis, and alpha-1 antitrypsin deficiency, who have exhausted all other medical treatments and continue to suffer from severe respiratory failure.

The procedure involves several steps, including evaluating the patient's eligibility for transplantation, matching the donor's lung size and blood type with the recipient, and performing the surgery under general anesthesia. After the surgery, patients require close monitoring and lifelong immunosuppressive therapy to prevent rejection of the new lungs.

Lung transplantation can significantly improve the quality of life and survival rates for some patients with end-stage lung disease, but it is not without risks, including infection, bleeding, and rejection. Therefore, careful consideration and thorough evaluation are necessary before pursuing this treatment option.

Collagen Type V is a specific type of collagen, which is a protein that provides structure and strength to connective tissues in the body. Collagen Type V is found in various tissues, including the cornea, blood vessels, and hair. It plays a crucial role in the formation of collagen fibers and helps regulate the diameter of collagen fibrils. Mutations in the genes that encode for Collagen Type V can lead to various connective tissue disorders, such as Ehlers-Danlos syndrome and osteogenesis imperfecta.

A tissue donor is an individual who has agreed to allow organs and tissues to be removed from their body after death for the purpose of transplantation to restore the health or save the life of another person. The tissues that can be donated include corneas, heart valves, skin, bone, tendons, ligaments, veins, and cartilage. These tissues can enhance the quality of life for many recipients and are often used in reconstructive surgeries. It is important to note that tissue donation does not interfere with an open casket funeral or other cultural or religious practices related to death and grieving.

Bronchiolitis obliterans is a medical condition characterized by the inflammation and scarring (fibrosis) of the bronchioles, which are the smallest airways in the lungs. This results in the narrowing or complete obstruction of the airways, leading to difficulty breathing and reduced lung function.

The condition is often caused by a respiratory infection, such as adenovirus or mycoplasma pneumonia, but it can also be associated with exposure to certain chemicals, drugs, or radiation therapy. In some cases, the cause may be unknown.

Symptoms of bronchiolitis obliterans include cough, shortness of breath, wheezing, and crackles heard on lung examination. Diagnosis typically involves a combination of medical history, physical exam, imaging studies (such as chest X-ray or CT scan), and pulmonary function tests. In some cases, a biopsy may be necessary to confirm the diagnosis.

Treatment for bronchiolitis obliterans is focused on managing symptoms and preventing further lung damage. This may include bronchodilators to help open up the airways, corticosteroids to reduce inflammation, and oxygen therapy to help with breathing. In severe cases, a lung transplant may be necessary.

Graft survival, in medical terms, refers to the success of a transplanted tissue or organ in continuing to function and integrate with the recipient's body over time. It is the opposite of graft rejection, which occurs when the recipient's immune system recognizes the transplanted tissue as foreign and attacks it, leading to its failure.

Graft survival depends on various factors, including the compatibility between the donor and recipient, the type and location of the graft, the use of immunosuppressive drugs to prevent rejection, and the overall health of the recipient. A successful graft survival implies that the transplanted tissue or organ has been accepted by the recipient's body and is functioning properly, providing the necessary physiological support for the recipient's survival and improved quality of life.

Graft rejection is an immune response that occurs when transplanted tissue or organ (the graft) is recognized as foreign by the recipient's immune system, leading to the activation of immune cells to attack and destroy the graft. This results in the failure of the transplant and the need for additional medical intervention or another transplant. There are three types of graft rejection: hyperacute, acute, and chronic. Hyperacute rejection occurs immediately or soon after transplantation due to pre-existing antibodies against the graft. Acute rejection typically occurs within weeks to months post-transplant and is characterized by the infiltration of T-cells into the graft. Chronic rejection, which can occur months to years after transplantation, is a slow and progressive process characterized by fibrosis and tissue damage due to ongoing immune responses against the graft.

In the field of medicine, "time factors" refer to the duration of symptoms or time elapsed since the onset of a medical condition, which can have significant implications for diagnosis and treatment. Understanding time factors is crucial in determining the progression of a disease, evaluating the effectiveness of treatments, and making critical decisions regarding patient care.

For example, in stroke management, "time is brain," meaning that rapid intervention within a specific time frame (usually within 4.5 hours) is essential to administering tissue plasminogen activator (tPA), a clot-busting drug that can minimize brain damage and improve patient outcomes. Similarly, in trauma care, the "golden hour" concept emphasizes the importance of providing definitive care within the first 60 minutes after injury to increase survival rates and reduce morbidity.

Time factors also play a role in monitoring the progression of chronic conditions like diabetes or heart disease, where regular follow-ups and assessments help determine appropriate treatment adjustments and prevent complications. In infectious diseases, time factors are crucial for initiating antibiotic therapy and identifying potential outbreaks to control their spread.

Overall, "time factors" encompass the significance of recognizing and acting promptly in various medical scenarios to optimize patient outcomes and provide effective care.

A biological marker, often referred to as a biomarker, is a measurable indicator that reflects the presence or severity of a disease state, or a response to a therapeutic intervention. Biomarkers can be found in various materials such as blood, tissues, or bodily fluids, and they can take many forms, including molecular, histologic, radiographic, or physiological measurements.

In the context of medical research and clinical practice, biomarkers are used for a variety of purposes, such as:

1. Diagnosis: Biomarkers can help diagnose a disease by indicating the presence or absence of a particular condition. For example, prostate-specific antigen (PSA) is a biomarker used to detect prostate cancer.
2. Monitoring: Biomarkers can be used to monitor the progression or regression of a disease over time. For instance, hemoglobin A1c (HbA1c) levels are monitored in diabetes patients to assess long-term blood glucose control.
3. Predicting: Biomarkers can help predict the likelihood of developing a particular disease or the risk of a negative outcome. For example, the presence of certain genetic mutations can indicate an increased risk for breast cancer.
4. Response to treatment: Biomarkers can be used to evaluate the effectiveness of a specific treatment by measuring changes in the biomarker levels before and after the intervention. This is particularly useful in personalized medicine, where treatments are tailored to individual patients based on their unique biomarker profiles.

It's important to note that for a biomarker to be considered clinically valid and useful, it must undergo rigorous validation through well-designed studies, including demonstrating sensitivity, specificity, reproducibility, and clinical relevance.

Kidney transplantation is a surgical procedure where a healthy kidney from a deceased or living donor is implanted into a patient with end-stage renal disease (ESRD) or permanent kidney failure. The new kidney takes over the functions of filtering waste and excess fluids from the blood, producing urine, and maintaining the body's electrolyte balance.

The transplanted kidney is typically placed in the lower abdomen, with its blood vessels connected to the recipient's iliac artery and vein. The ureter of the new kidney is then attached to the recipient's bladder to ensure proper urine flow. Following the surgery, the patient will require lifelong immunosuppressive therapy to prevent rejection of the transplanted organ by their immune system.

Prospective studies, also known as longitudinal studies, are a type of cohort study in which data is collected forward in time, following a group of individuals who share a common characteristic or exposure over a period of time. The researchers clearly define the study population and exposure of interest at the beginning of the study and follow up with the participants to determine the outcomes that develop over time. This type of study design allows for the investigation of causal relationships between exposures and outcomes, as well as the identification of risk factors and the estimation of disease incidence rates. Prospective studies are particularly useful in epidemiology and medical research when studying diseases with long latency periods or rare outcomes.

Liver transplantation is a surgical procedure in which a diseased or failing liver is replaced with a healthy one from a deceased donor or, less commonly, a portion of a liver from a living donor. The goal of the procedure is to restore normal liver function and improve the patient's overall health and quality of life.

Liver transplantation may be recommended for individuals with end-stage liver disease, acute liver failure, certain genetic liver disorders, or liver cancers that cannot be treated effectively with other therapies. The procedure involves complex surgery to remove the diseased liver and implant the new one, followed by a period of recovery and close medical monitoring to ensure proper function and minimize the risk of complications.

The success of liver transplantation has improved significantly in recent years due to advances in surgical techniques, immunosuppressive medications, and post-transplant care. However, it remains a major operation with significant risks and challenges, including the need for lifelong immunosuppression to prevent rejection of the new liver, as well as potential complications such as infection, bleeding, and organ failure.

Delayed graft function (DGF) is a term used in the medical field, particularly in transplant medicine. It refers to a situation where a transplanted organ, most commonly a kidney, fails to function normally immediately after the transplantation procedure. This failure to function occurs within the first week after the transplant and is usually associated with poor urine output and elevated levels of creatinine in the blood.

DGF can be caused by several factors, including pre-existing conditions in the recipient, such as diabetes or hypertension, poor quality of the donor organ, or complications during the surgery. It may also result from the immune system's reaction to the transplanted organ, known as rejection.

In many cases, DGF can be managed with medical interventions, such as administering medications to help reduce inflammation and improve blood flow to the organ. However, in some instances, it may lead to more severe complications, including acute or chronic rejection of the transplanted organ, which could require additional treatments or even another transplant.

It's important to note that not all cases of DGF lead to long-term complications, and many patients with DGF can still go on to have successful transplants with proper management and care.

10 January 2013). "Clinical risk factors for primary graft dysfunction after lung transplantation". American Journal of ...
October 2008). "Anti-type V collagen humoral immunity in lung transplant primary graft dysfunction". Journal of Immunology. 181 ...
... in patients with primary nonfunction and other causes of graft dysfunction after liver transplantation in the era of extended ... the patient to receive a re-transplant if the above goal is not achieved MARS Therapy Indication Primary graft dysfunction ... Cell sources now include primary porcine hepatocytes, primary human hepatocytes, human hepatoblastoma (C3A), immortalized human ... Primary biliary cirrhosis (PBC), primary sclerosing cholangitis (PSC) Benign intrahepatic cholestasis (BIC) Biliary Atresia ...
... genetic profiling of embryos prior to implantation Primary graft dysfunction, a complication of organ transplantation Prolonged ...
... and primary graft dysfunction after lung transplant. The most common causes of ARDS are pneumonia, non-pulmonary sepsis, and ... Of the patients who succumb to ARDS, the most common cause of death is septic shock with multi organ dysfunction syndrome. ...
... untranslated region of PTGER4 has been associated with and increase rate of primary graft dysfunction in a multicentered cohort ...
Madhavan, Malini; Graff-Radford, Jonathan; Piccini, Jonathan P.; Gersh, Bernard J. (December 2018). "Cognitive dysfunction in ... Screening in primary care has been trialled in a number of countries. These include: a recent Canadian study conducted in 184 ... Diastolic dysfunction is also associated with AF, which increases left atrial pressure, left atrial volume, size, and left ... Also, this system does not apply to cases where the AF is a secondary condition that occurs in the setting of a primary ...
ISBN 978-0-8044-2229-1. Stanton, Robert J. (1980). Truman Capote: A Primary and Secondary Bibliography (1st ed.). New York: G K ... Overall the stories are noted for involving "sexual anxiety and dysfunction without solidly grounded detail." In 1950, A Tree ... Capote: a Biography (1998) Carroll & Graff. ISBN 978-0-7867-1661-6 p. 85 Bercovitch, Sacvan The Cambridge History of American ... Capote: A Biography (1998) Carroll & Graff. ISBN 978-0-7867-1661-6 p. 224 Bibliography Bercovitch, Sacvan (1999). The Cambridge ...
A target trough level of 3 ng/mL at 3 months was shown to be beneficial in recipients with pre-transplant renal dysfunction. In ... The experimental use of everolimus in refractory chronic graft-versus-host disease was reported in 2012. Interim phase III ... A positive impact on hepatocellular carcinoma (HCC) was observed when everolimus was used as primary immunosuppression starting ... due to possible early hepatic artery thrombosis and graft loss, use of everolimus in the setting of liver transplantation is ...
These are known as primary BK infections. Although without any clinical symptoms, footprints of BK virus have been detected in ... Quinolone antibiotics: Ciprofloxacin (Cipro) was shown to significantly lower viral loads but no data on survival and graft ... Clinical manifestations include renal dysfunction (seen by a progressive rise in serum creatinine), and an abnormal urinalysis ... of these patients lose their grafts. The onset of nephritis can occur as early as several days post-transplant to as late as 5 ...
Noradrenaline and its precursor L-DOPS are used for primary autonomic dysfunction by increasing vascular tone. Erythropoietin ... coronary artery bypass graft surgery) for infarction, steroids for adrenal insufficiency, etc...) The best way to determine if ... "Diagnosis and Treatment of Primary Adrenal Insufficiency: An Endocrine Society Clinical Practice Guideline". The Journal of ...
Medicine portal Bone grafting Gingival graft Periodontitis Sinus lift Severity: Interdental clinical attachment level at site ... The primary aetiological factor for periodontal disease is plaque biofilm of dental biofilm. A dental biofilm is a community of ... masticatory dysfunction. Add to Stage as descriptor: Localized < 30% teeth, generalized > or equal to 30%. Anticipated ... ISBN 978-0-323-69550-3. de Vries, Kevin (July 2015). "Primary care: Gingivitis". The Australian Journal of Pharmacy. 96 (1141 ...
According to several studies, coronary artery bypass graft surgery has a survival advantage over medical therapy (for ischemic ... Myocardial imaging usually demonstrates left ventricular dilation, severe ventricular dysfunction, and multiple infarctions. ... is often used to differentiate primary from ischemic cardiomyopathy, and as a prognostic indicator. A 2004 study showed the ... 2008). "The myoblast autologous grafting in ischemic cardiomyopathy (MAGIC) trial first randomized Placebo-controlled study of ...
Immunosuppression is the primary determinant of outcome in small bowel transplantation; the risk for graft rejection is ... The common symptom of graft dysfunction, whether due to infection, rejection, or some other condition, is diarrhea. Intestinal ... In a multivisceral graft, the stomach, duodenum, pancreas, and/or colon may be included in the graft. Multivisceral grafts are ... In the most basic and common graft, an isolated intestinal graft, only sections of the jejunum and ileum are transplanted. ...
LiMAx demonstrated high diagnostic accuracy in detecting early transplant dysfunction or non-function of liver grafts allowing ... Early diagnosis of primary nonfunction and indication for reoperation after liver transplantation. Liver transplantation 2010; ...
In the McIndoe procedure, a skin graft is applied to form an artificial vagina. After the surgery, dilators are still necessary ... Müllerian agenesis (including absence of the uterus, cervix and/or vagina) is the cause in 15% of cases of primary amenorrhoea ... "WNT4 Müllerian aplasia and ovarian dysfunction". Genetics Home Reference. Archived from the original on 2014-06-14. Retrieved ... Akhter N, Begum B (3 February 2013). "Evaluation and management of cases of primary amenorrhoea with MRKH syndrome". Bangladesh ...
Severe side effects include brain dysfunction, low blood cell counts, and lung inflammation. Use in pregnancy will likely ... The profound lymphopenia caused by fludarabine renders patients susceptible to transfusion-associated graft versus host disease ... December 2000). "Fludarabine compared with chlorambucil as primary therapy for chronic lymphocytic leukemia". The New England ...
Upon retrieval, the buccal graft is presented to the urethral surgeon, who will then prepare the graft by trimming and removal ... primary selection) availability of autograft tissue from the penis and scrotum (secondary selection) skill level and training ... which could result in erectile dysfunction or loss of tactile sensation of the penis). The area of the defect is evaluated and ... "Buccal Mucosal Urethral Graft, how to do it" (PDF). The Center for Reconstructive Urethral Surgery. El-Kasaby, Abdel Wahab; El- ...
Primary Sjögren's syndrome is the combination of dry eyes and xerostomia. Secondary Sjögren's syndrome is identical to primary ... Xerostomia may be a consequence of infection with hepatitis C virus (HCV) and a rare cause of salivary gland dysfunction may be ... Hormonal disorders, such as poorly controlled diabetes, chronic graft versus host disease or low fluid intake in people ... Xerostomia may also result from a change in composition of saliva (from serous to mucous). Salivary gland dysfunction is an ...
This favorable radiographic response could be expected within one year following the procedure - nevertheless, primary graft ... Additionally, extramedullary hematopoiesis can result in liver and spleen dysfunction. Cranial nerve dysfunction and neurologic ...
Stents and stent-grafts: Stents are used to provide a scaffold along a segment of diseased vessel. These are available in a ... A variety of interventional oncological treatments for tumors arise: Liver cancer: primary liver tumors such as hepatocellular ... most commonly by atherosclerotic disease The classic symptoms include buttock claudication and erectile dysfunction, with ... An arteriovenous graft (AVG) relies on the same principle but bridges the gap between the artery and vein with a medical-grade ...
The primary ligand of LPAM-1 is the mucosal vascular addressin cell adhesion molecule 1 (MAdCAM-1) which is specifically ... LPAM-1 integrin is involved in the development of graft-versus-host disease (GVHD). Donor-derived CTL cells use α4β7 integrin ... In acute HIV-1 infection, gastrointestinal dysfunction can be observed. Gut-associated lymphoid tissue represents a key site ...
Efficacy was assessed in a pre-specified subgroup of 122 participants with dMMR/MSI-H primary advanced or recurrent EC. MMR/MSI ... nephritis with renal dysfunction, and dermatologic reactions. Dostarlimab can cause harm to a fetus. The death of the fetus can ... grafting. Its serum half-life is 25.4 days. Other PD-1 antibodies included nivolumab (Opdivo) and pembrolizumab (Keytruda), ... Kasherman L, Ahrari S, Lheureux S (March 2021). "Dostarlimab in the treatment of recurrent or primary advanced endometrial ...
Most patients with excoriation disorder report having a primary area of the body that they focus their picking on, but they ... Damage from picking can be so severe as to require skin grafting, and severe picking can cause epidermal abscesses. Severe ... Thus, excoriation disorder could result from a dysfunction in the dopamine reward functions. There may be another neurological ... Excoriation disorder occurs as the primary disorder and not as a subset of a larger disorder. Excoriation disorder has well- ...
The primary documented driver of this process is oxidized lipoprotein particles within the wall, beneath the endothelial cells ... Coronary artery bypass grafting without manipulation of the ascending aorta has demonstrated reduced rates of postoperative ... Pigozzi F, Rizzo M, Fagnani F, Parisi A, Spataro A, Casasco M, Borrione P (June 2011). "Endothelial (dys)function: the target ... A number of procedures may also be carried out such as percutaneous coronary intervention, coronary artery bypass graft, or ...
Augmented grafting is often an additional procedure to refine the structure of the reconstructed nipple that experienced ... The areolas cellular composition includes an assortment of cells and specific tissues that support the primary function of the ... Post-procedure, patients might suffer from body image issues, sexual dysfunction, and low self-esteem. NAC reconstruction has ... In 1949, Adams used a composite graft from the labia minora, which is the skin surrounding the vagina, to create the first ...
The grafts are obtained in one or both of the two primary methods of surgical extraction, follicular unit transplantation, ... It may cause gynecomastia, erectile dysfunction and depression. Dutasteride is also used in the treatment of male pattern hair ... Hair transplantation differs from skin grafting in that grafts contain almost all of the epidermis and dermis surrounding the ... Small grafts of naturally-occurring units of one to four hairs, called follicular units, can be moved to balding areas of the ...
When a neovagina is made from a segment of bowel, it tends to leak mucus; when made with a skin graft, lubrication is necessary ... Potential surgical problems: The primary effect of this surgery is a drastic reduction in ability to experience orgasm. The ... though similar women who had not had surgery also report a high rate of sexual dysfunction. Clitoral reduction was developed in ... Another is to line the new vagina with a skin graft. Potential surgical problems: Stenosis (narrowing) of the constructed ...
... folliculitis Primary cutaneous aspergillosis Primary cutaneous coccidioidomycosis Primary cutaneous histoplasmosis Primary ... Graft-versus-host disease Griscelli syndrome Hyper-IgE syndrome (Buckley syndrome, Job syndrome) Immunodeficiency with hyper- ... Arthrogryposis-renal dysfunction-cholestasis syndrome Ataxia telangiectasia (Louis-Bar syndrome) Atrichia with papular lesions ... primary neuroendocrine carcinoma of the skin, primary small cell carcinoma of the skin, trabecular carcinoma of the skin) ...
... slight increase in white blood count and graft-site tenderness.[citation needed] Three types of graft rejection may occur: ... Acute rejection is the most common and the primary target of immunosuppressive agents. Acute rejection is usually seen within ... liver dysfunction. Since the procedure carries relatively high risks, is resource-intensive, and requires major life ... for those with primary liver cancer or secondary spread to the liver, the medical team will likely rely heavily on the opinion ...
Learn about Primary Graft Dysfunction at online-medical-dictionary.org ... It is most often seen in the transplanted lung, liver, or kidney and can lead to GRAFT REJECTION. ... Significant pathophysiological changes in MITOCHONDRIA are the main cause of the dysfunction. ... Dysfunction, Primary Graft. Graft Dysfunction, Primary. A form of ischemia-reperfusion injury occurring in the early period ...
... referred to as severe graft dysfunction.. RESULTS: Of the total cohort (n... (More). INTRODUCTION: Primary graft dysfunction ( ... INTRODUCTION: Primary graft dysfunction (PGD) is a leading cause of 30-day mortality following heart transplantation, and early ... Myocardial injury biomarkers at point of care for early identification of primary graft dysfunction after heart transplantation ... article{8f4df24a-c2ad-420c-9369-1b2a8bae7b50, abstract = {{,p,INTRODUCTION: Primary graft dysfunction (PGD) is a leading cause ...
ISHLT Working Group on Primary Lung Graft Dysfunction. Report of the ISHLT Working Group on Primary Lung Graft Dysfunction part ... Primary graft dysfunction. Acute lung injury of newly transplanted lungs has been called numerous names; however, the term ... Late primary graft dysfunction after lung transplantation and bronchiolitis obliterans syndrome. Am J Transplant. Nov 2008. 8: ... 70] This new model may provide investigators a new path to study perplexing problems such as BO and primary graft dysfunction ( ...
... Galeone A. ;Varnous S;Salem J;Lebreton G;Coutance G;Hulot J;Leprince P. 2018-01- ... Recipients who needed a postoperative ecmo for primary graft dysfunction had significantly higher serum levels of sST2 in their ... Recipients who needed a postoperative ecmo for primary graft dysfunction had significantly higher serum levels of sST2 in their ... Conclusion: Higher sST2 serum levels in donors are associated with primary graft dysfunction in recipients; higher sST2 serum ...
Reduction of primary graft dysfunction using cytokine adsorption during organ preservation and after lung transplantation * ... Reduction of primary graft dysfunction using cytokine adsorption during organ preservation and after lung transplantation * ... Soluble P-selectin and the risk of primary graft dysfunction after lung transplantation. Chest 136, 237-244 (2009). ... Interleukin-8 release during early reperfusion predicts graft function in human lung transplantation. Am. J. Respir. Crit. Care ...
abstract = "Primary graft dysfunction (PGD) is the leading cause of morbidity and mortality in the first 30 days after lung ... N2 - Primary graft dysfunction (PGD) is the leading cause of morbidity and mortality in the first 30 days after lung ... AB - Primary graft dysfunction (PGD) is the leading cause of morbidity and mortality in the first 30 days after lung ... Primary graft dysfunction (PGD) is the leading cause of morbidity and mortality in the first 30 days after lung transplantation ...
Donor Hypernatremia is Not Related with the Duration of Postoperative Mechanical Ventilation, Primary Graft Dysfunction, or ... Donor Hypernatremia is Not Related with the Duration of Postoperative Mechanical Ventilation, Primary Graft Dysfunction, or ... Donor Hypernatremia is Not Related with the Duration of Postoperative Mechanical Ventilation, Primary Graft Dysfunction, or ... Donor Hypernatremia is Not Related with the Duration of Postoperative Mechanical Ventilation, Primary Graft Dysfunction, or ...
10 January 2013). "Clinical risk factors for primary graft dysfunction after lung transplantation". American Journal of ...
Report primary graft dysfunction in heart transplant recipients. Changes implemented with this policy modify the Heart and ...
Overcoming primary graft dysfunction after lung transplantation: are we finding our way there? Bertani A. Bertani A. ... A project to assess the quality of the published guidelines for managing primary spontaneous pneumothorax from the Italian ...
1. Soluble P-Selectin and the Risk of Primary Graft Dysfunction After Lung Transplantation Kawut, Steven M.; Okun, Jeffrey; ...
Poor function of the transplanted lungs (primary graft dysfunction). *Infection. *Acute rejection ...
... which leads to primary graft dysfunction and affects patients survival rate. Bone marrow mesenchymal stem cells (BMSCs) have ... which leads to primary graft dysfunction and affects patients survival rate. Bone marrow mesenchymal stem cells (BMSCs) have ... of recipients have suffered from primary graft dysfunction (PGD) after heart transplantation(3). ... graft dysfunction after heart transplantation and that these cardioprotective effects could be enhanced by hypoxic ...
Chronic graft dysfunction, intensifying immunosuppression, and SARS-CoV-2 infection in this patient could have favored ... His primary research interests are emerging pathogens and antimicrobial drug resistance.. Top ... In 2021, she experienced progressive graft dysfunction with no obvious trigger and was treated with alemtuzumab in June 2021. ... It is possible that the chronic graft dysfunction, the recent intensification of immunosuppression, and the SARS-CoV-2 ...
The primary endpoint was early allograft dysfunction (EAD). We analyzed multiple secondary endpoints including postoperative ... graft rejection, graft survival, Hepatic Artery, Hospital Mortality, Humans, incidence, Kidney Function Tests, length of stay, ... Among the postoperative graft function parameters, postoperative alanine aminotransferase level was significantly lower in the ... Abstract : The role of prostaglandin E1 (PGE1) infusion in improving early graft function has not been well defined, especially ...
Pre-Procurement In Situ Donor Lung Tissue Gene Expression Classifies Primary Graft Dysfunction Risk Am J Respir Crit Care Med ... Extended post-ex vivo lung perfusion cold preservation predicts primary graft dysfunction and mortality: Results from a ... Primary Location. Penn Heart and Vascular Center Perelman Center for Advanced Medicine. East Pavilion, 2nd Floor. 3400 Civic ...
Primary graft dysfunction attenuates improvements in health-related quality of life after lung transplantation, but not ... Preventing occupational illness and injury: nurse practitioners as primary care providers.. American journal of public health ... Depressive symptoms in lung transplant recipients: trajectory and association with mortality and allograft dysfunction.. Thorax ...
Short Airway Telomeres are Associated with Primary Graft Dysfunction and Chronic Lung Allograft Dysfunction. J Heart Lung ... Lung Allograft Epithelium DNA Methylation Age Is Associated With Graft Chronologic Age and Primary Graft Dysfunction. Front ... Pulmonary Hypertension and Primary Graft Dysfunction in Lung Transplant Recipients: We Still Have a Long Way to Go. Ann Am ... The Clinical and Molecular Impacts of Lung Primary Graft Dysfunction. NHLBI U01-HL163294May 14, 2022 - May 14, 2027. Role: Co-I ...
Primary graft dysfunction attenuates improvements in health-related quality of life after lung transplantation, but not ... NKG2D receptor activation drives primary graft dysfunction severity and poor lung transplantation outcomes. JCI Insight. 2022 ... Bronchoalveolar Lavage MICB is Associated with Severe Primary Graft Dysfunction, Prolonged Mechanical Ventilation, and Low Post ... BRAF mutations in cutaneous melanoma are independently associated with age, anatomic site of the primary tumor, and the degree ...
NKG2D receptor activation drives primary graft dysfunction severity and poor lung transplantation outcomes. JCI Insight. 2022 ... Bronchoalveolar Lavage MICB is Associated with Severe Primary Graft Dysfunction, Prolonged Mechanical Ventilation, and Low Post ...
Re-transplantation remains the only therapeutic option in some cases of severe primary graft dysfunction, severe untreatable ... Graft survival of re-transplantation (median survival 76 months; 95% CI 22.2-115.7) was comparable to that of primary ... 30-day transplant survival was 89.1%; causes of early death or graft failure were multi-organ failure, primary transplant ... graft versus host disease and primary pulmonary hypertension).. 5 yrs post-transplant, kidney function was impaired in 66.7% of ...
Spectral Doppler ultrasonogram of the portal vein was obtained at the onset of graft dysfunction. Compared with the baseline ... Recurrent primary biliary cirrhosis, primary sclerosing cholangitis, and autoimmune hepatitis after transplantation. Semin ... Spectral Doppler ultrasonogram of the portal vein was obtained at the onset of graft dysfunction. Compared with the baseline ... Other than excluding other causes of graft dysfunction, the modalities are not helpful in diagnosing recurrent hepatitis B ...
6. Cytokine Biomarkers as Indicators of Primary Graft Dysfunction, Acute Rejection, and Chronic Lung Allograft Dysfunction in ...
Biomarkers of lung injury in primary graft dysfunction following lung transplantation. Biomark Med. 2007;1(2):285-291. ... Bae KM, Wang H, Jiang G, Chen MG, Lu L, Xiao L. Protein kinase C epsilon is overexpressed in primary human non-small cell lung ... Culture and laboratory study of airway epithelium from patients with primary ciliary dyskinesia. Presented at the International ... Reversal of chronic rhinosinusitis-associated sinonasal ciliary dysfunction. Am J Rhinol. 2007;21(3):346-353. ...
The incidence of primary graft dysfunction-a post-operative condition that leads to early morbidity and mortality in lung ... Once A1AT reaches lung cells, its primary role is to block signal transduction pathways triggering the production of ...
The analysis showed a statistically significant 72% reduction p=0.005) in Severe Primary Graft Dysfunction (PGD) rates.1,2 The ... 71.9% reduction in Severe PGD (primary graft dysfunction) (p=0.005)1,2 ...
Primary graft dysfunction after living donor liver transplantation is characterized by delayed functional hyperbilirubinemia. ... Organ survival after primary dysfunction of liver grafts in clinical orthotopic liver transplantation. ... Primary graft dysfunction of the liver: definitions, diagnostic criteria and risk factors. ... Impact of early graft dysfunction on two-year survival. One Kaplan-Meier curve is presented for each diagnostic method applied ...
Oxidative phosphorylation and mitochondrial dysfunction were the top molecular pathways associated with overexpressed genes in ... samples served as positive controls to validate CNIT marker specificity and were characterized by other common causes of graft ... has been associated with the development of chronic renal allograft dysfunction and decreased graft survival. This study ... Although it was not our primary objective to characterize the molecular profiles of AR and IFTA samples, we did observe ...
Seventy-two-hour primary graft dysfunction (PGD) and chronic lung allograft dysfunction (CLAD) did not differ between the two ... Survival, graft dysfunction, pulmonary artery pressure (PAP), complications, and bilateral LT (BLT) were compared between the ... However, overall survival and graft dysfunction did not differ between the two groups, which suggests that ECMO improves the ...
  • It is most often seen in the transplanted lung , liver , or kidney and can lead to GRAFT REJECTION . (online-medical-dictionary.org)
  • Primary graft dysfunction (PGD) is the leading cause of morbidity and mortality in the first 30 days after lung transplantation. (wustl.edu)
  • However, it is unknown what effect donor hypernatremia has on graft and recipient outcomes after lung transplantation. (rug.nl)
  • The aim of this study was to investigate the relation of donor hypernatremia with the duration of postoperative mechanical ventilation, the incidence of severe primary graft dysfunction, and survival following lung transplantation. (rug.nl)
  • We report a case of I. limosus bacteremia in a patient in France who received a lung transplant and experienced chronic graft dysfunction and SARS-CoV-2 infection. (cdc.gov)
  • Indeed, the lung graft microbiome is affected by donor and recipient factors ( 6 ), but early posttransplant infections mainly involve the bacteria of the recipient rather than those of the donor ( 7 ). (cdc.gov)
  • Depressive symptoms in lung transplant recipients: trajectory and association with mortality and allograft dysfunction. (ucsf.edu)
  • Small airway lymphocytic inflammation in chronic lung allograft dysfunction? (ucsf.edu)
  • Bae KM, Wang H, Jiang G, Chen MG, Lu L, Xiao L. Protein kinase C epsilon is overexpressed in primary human non-small cell lung cancers and functionally required for proliferation of non-small cell lung cancer cells in a p21/Cip1-dependent manner. (famri.org)
  • Seventy-two-hour primary graft dysfunction (PGD) and chronic lung allograft dysfunction (CLAD) did not differ between the two groups. (minervamedica.it)
  • The study will compare the time to a composite endpoint of relative decline in lung function [10% relative decline in forced vital capacity (FVC), first respiratory hospitalization, lung transplantation, or all-cause mortality] The secondary objectives will be to examine the effect of NAC on the components of the primary composite endpoint, the rates of clinical events, change in physiology, change in health status, and change in respiratory symptoms. (stanford.edu)
  • The aim of this study is to assess the relationship between center volume and FTR following lung transplantation.Using the database of the United Network for Organ Sharing (UNOS) all adult, primary, isolated lung recipients in the United States between May 2005 and March 2016 were identified. (stanford.edu)
  • Purpose: To evaluate the association between donors' and recipients' serum levels of soluble ST2 (sST2) and recipients' primary graft dysfunction and 1-year outcome (mortality and incidence of allograft rejection). (univr.it)
  • All of these factors are known to result in myocardial apoptosis(5) and the acceleration of allograft rejection or chronic allograft dysfunction. (researchsquare.com)
  • His postoperative course was complicated by severe primary graft dysfunction (PGD 3), acute rejection, renal failure requiring hemodialysis, tracheostomy placement, Clostridium difficile colitis and ileitis, cytomegaloviral viremia, bilateral upper extremity deep venous thrombi, pleurocutaneous fistula of the right chest necessitating pleurodesis, atrial fibrillation, and a gastrointestinal bleed. (hindawi.com)
  • Graft rejection. (lookformedical.com)
  • It is used for the prophylaxis of graft rejection in organ and tissue transplantation. (lookformedical.com)
  • Background: T cell-mediated acute rejection(AR) after heart transplantation(HT) ultimately results in graft failure and is a common indication for secondary transplantation. (bvsalud.org)
  • BACKGROUND Donor hypernatremia has been associated with reduced graft and recipient survival after heart, liver, kidney, and pancreas transplantation. (rug.nl)
  • Donor hypernatremia was not associated with (graft) survival, or after correction for potential confounders. (rug.nl)
  • In heart transplantation, donor hearts inevitably suffer from ischemia/reperfusion (I/R) injury, which leads to primary graft dysfunction and affects patients' survival rate. (researchsquare.com)
  • We hypothesized that the donor heart preservation with hypoxic conditioned medium derived from BMSCs (CM-BMSCs) would improve post-transplant graft function. (researchsquare.com)
  • The role of prostaglandin E1 (PGE1) infusion in improving early graft function has not been well defined, especially in the scenario of living donor liver transplantation (LDLT). (amrita.edu)
  • Risk factors for graft steatosis mainly include obesity, im munosuppression, donor steatosis, and genetic factors. (wjgnet.com)
  • An induced state of non-reactivity to grafted tissue from a donor organism that would ordinarily trigger a cell-mediated or humoral immune response. (lookformedical.com)
  • eg, bone, bone marrow, and skin grafts) Genetically identical (syngeneic [between monozygotic twins]) donor tissue (isografts) Genetically. (msdmanuals.com)
  • Kidney injury associated with cold storage/transplantation is a primary factor for delayed graft function and poor outcome of renal transplants. (elsevierpure.com)
  • Additionally, 5% to 10% of recipients have suffered from primary graft dysfunction (PGD) after heart transplantation(3). (researchsquare.com)
  • Hepatitis C virus , hepatocellular carcinoma (HCC) , chronic renal dysfunction , and alcohol relapse continue to be major challenges, and continued research in these areas will undoubtedly lead to better outcomes for transplant recipients. (medscape.com)
  • The primary outcome was severe PGD or the need for veno-arterial extracorporeal membrane oxygenation within 7 days, referred to as severe graft dysfunction. (lu.se)
  • RESULTS: Of the total cohort (n = 63), eight patients (13%) were diagnosed with severe graft dysfunction within 7 days. (lu.se)
  • Patients with high CK-MB had an increased risk for severe graft dysfunction with unadjusted Odds Ratio (OR) of 4.5 (95%CI .96-21.11 P = .057) and adjusted OR of 7.4 (95%CI 1.13-48.46, P = .037. (lu.se)
  • Severe primary graft dysfunction was not different between the 3 groups (29%, 26%, 28%, P=0.724). (rug.nl)
  • Relation between diagnostic criteria for early graft dysfunction and outcome. (medintensiva.org)
  • The primary outcome consisted of criteria for liver graft viability assessment. (eur.nl)
  • Abdominal normothermic regional perfusion (aNRP) can reverse ischemic injury early during the procurement procedure, and it simultaneously enables graft viability testing to unravel this black box. (eur.nl)
  • INTRODUCTION: Primary graft dysfunction (PGD) is a leading cause of 30-day mortality following heart transplantation, and early intervention in PGD may correlate to improved survival. (lu.se)
  • Comparison of different diagnostic criteria for early liver allograft dysfunction (EAD) and their capability to predict mortality. (medintensiva.org)
  • Differences in the incidence of EAD and its relation with ICU, Hospital and 2-year mortality depending on the definition applied using as comparator the UNOS (United Network for Organ Sharing) primary non-function criterion. (medintensiva.org)
  • C-1: Gortex hepatic artery graft thrombosis in a 59-year-old man (shown by arrow). (medscape.com)
  • Typical indications include leukemia, myelodysplasia, aplastic anemia, solid tumors, congenital or acquired/medication-induced platelet dysfunction, central nervous system trauma, and patients undergoing extracorporeal membrane oxygenation or cardiopulmonary bypass may also need platelet transfusion. (medscape.com)
  • Platelet transfusions may be given for thrombocytopenia or platelet dysfunction to treat active platelet-related bleeding or as prophylaxis in those at serious risk of bleeding. (medscape.com)
  • Survival, graft dysfunction, pulmonary artery pressure (PAP), complications, and bilateral LT (BLT) were compared between the ECMO group and the non-ECMO group. (minervamedica.it)
  • However, overall survival and graft dysfunction did not differ between the two groups, which suggests that ECMO improves the chance for the patients in critical condition to survive LT. (minervamedica.it)
  • abstract = "Acceptance of liver grafts from donations after circulatory death (DCD) largely remains a "black box," particularly due to the unpredictability of the agonal phase. (eur.nl)
  • As of June 30, 2017, nearly 83,925 liver transplant recepients were living with a functioning liver graft. (medscape.com)
  • or actively by prior immunization of the recipient with graft antigens which evoke specific antibodies and form antigen-antibody complexes which bind to the antigen receptor sites of the T-cells and block their cytotoxic activity. (lookformedical.com)
  • formerly known as primary biliary cirrhosis) is an autoimmune liver disorder characterized by the progressive destruction of intrahepatic bile ducts, leading. (msdmanuals.com)
  • In a small group of patients with primary Sjögren syndrome, mycophenolate sodium reduced subjective, but not objective, ocular dryness and significantly reduced hypergammaglobulinemia and RF. (medscape.com)
  • Reports on the use of rituximab in patients with primary Sjögren syndrome have emerged in the literature. (medscape.com)
  • [ 84 ] In a randomized, placebo-controlled, parallel-group study of 120 patients with primary Sjögren syndrome, treatment with rituximab did not alleviate disease activity or symptoms at week 24, although it did alleviate some symptoms at weeks 6 and 16. (medscape.com)
  • In a prospective study of 78 patients with primary Sjögren syndrome treated with rituximab, significant improvement in extraglandular manifestations was reported, as measured by EULAR [European League Against Rheumatism] Sjögren Syndrome Disease Activity Index (ESSDAI) (disease activity score) and overall good tolerance reported. (medscape.com)
  • Patients are understandably concerned about this issue and, following months of erectile dysfunction, become skeptical of reassurances that their potency will return. (prostateprohelp.com)
  • The following list shows potential International Classification of Diseases, Ninth Revision, Clinical Modification diagnoses that could indicate candidacy for LT. The number of patients hospitalized with these primary and secondary diagnoses is enormous. (medscape.com)
  • For patients with liver metastases, transplantation is indicated only for neuroendocrine tumors without extrahepatic growth after removal of the primary tumor. (msdmanuals.com)
  • Higher transfusion thresholds may be appropriate for patients with platelet dysfunction. (medscape.com)
  • Among the biologic therapies, the greatest experience in primary Sjögren syndrome is with rituximab, an anti-CD20 (which is expressed on B-cell precursors) monoclonal antibody. (medscape.com)
  • Therefore, attenuating myocardial I/R injury during the heart transplant procedure would have a favorable impact on improving short- and long-term graft function and recipient's survival(6). (researchsquare.com)
  • Furthermore, gene-expression levels of proinflammatory cytokines in the transplanted graft, including interleukin-6 (P =.04) and macrophage inflammatory protein 2 (P =.03) were significantly decreased in the DN group. (elsevierpure.com)
  • The grafting of skin in humans or animals from one site to another to replace a lost portion of the body surface skin. (lookformedical.com)
  • The goal of the cornea ageing and rejuvenation project is to analyze the difference between a young adult versus an old adult in terms of their markers involved in ageing, senescence, inflammation, mitochrondria dysfunction and epithelial homeostasis. (stanford.edu)
  • Mitochondrial dysfunction is one of the critical hallmarks of both aging and inflammation. (stanford.edu)
  • We are further investigating the potential of this therapy in improving immune tolerance and graft versus host diseases associated with corneal transplantation. (stanford.edu)
  • Definitions of graft dysfunction criteria analyzed in the study. (medintensiva.org)
  • In 2021, she experienced progressive graft dysfunction with no obvious trigger and was treated with alemtuzumab in June 2021. (cdc.gov)
  • [ 86 , 87 ] Results from the AIR registry (French) indicated that rituximab appears to be effective in cryoglobulinemia or vasculitis-related peripheral nervous system involvement in primary Sjögren syndrome. (medscape.com)
  • The patient experienced no primary graft dysfunction. (duke.edu)
  • In cDCD, the 1-year graft and patient survival rates were 91% (89%-93%) and 93% (91%-94%), respectively. (eur.nl)