A form of ischemia-reperfusion injury occurring in the early period following transplantation. Significant pathophysiological changes in MITOCHONDRIA are the main cause of the dysfunction. It is most often seen in the transplanted lung, liver, or kidney and can lead to GRAFT REJECTION.
The transference of either one or both of the lungs from one human or animal to another.
A bibliographic database that includes MEDLINE as its primary subset. It is produced by the National Center for Biotechnology Information (NCBI), part of the NATIONAL LIBRARY OF MEDICINE. PubMed, which is searchable through NLM's Web site, also includes access to additional citations to selected life sciences journals not in MEDLINE, and links to other resources such as the full-text of articles at participating publishers' Web sites, NCBI's molecular biology databases, and PubMed Central.
A fibrillar collagen found widely distributed as a minor component in tissues that contain COLLAGEN TYPE I and COLLAGEN TYPE III. It is a heterotrimeric molecule composed of alpha1(V), alpha2(V) and alpha3(V) subunits. Several forms of collagen type V exist depending upon the composition of the subunits that form the trimer.
Extra impulse-conducting tissue in the heart that creates abnormal impulse-conducting connections between HEART ATRIA and HEART VENTRICLES.
Inflammation of the BRONCHIOLES leading to an obstructive lung disease. Bronchioles are characterized by fibrous granulation tissue with bronchial exudates in the lumens. Clinical features include a nonproductive cough and DYSPNEA.
The survival of a graft in a host, the factors responsible for the survival and the changes occurring within the graft during growth in the host.
Water content outside of the lung vasculature. About 80% of a normal lung is made up of water, including intracellular, interstitial, and blood water. Failure to maintain the normal homeostatic fluid exchange between the vascular space and the interstitium of the lungs can result in PULMONARY EDEMA and flooding of the alveolar space.
A condition characterized by recurring episodes of fluid leaking from capillaries into extra-vascular compartments causing hematocrit to rise precipitously. If not treated, generalized vascular leak can lead to generalized EDEMA; SHOCK; cardiovascular collapse; and MULTIPLE ORGAN FAILURE.
Measurement of blood flow based on induction at one point of the circulation of a known change in the intravascular heat content of flowing blood and detection of the resultant change in temperature at a point downstream.
A syndrome characterized by progressive life-threatening RESPIRATORY INSUFFICIENCY in the absence of known LUNG DISEASES, usually following a systemic insult such as surgery or major TRAUMA.
Excessive accumulation of extravascular fluid in the lung, an indication of a serious underlying disease or disorder. Pulmonary edema prevents efficient PULMONARY GAS EXCHANGE in the PULMONARY ALVEOLI, and can be life-threatening.
The transference of a heart from one human or animal to another.
An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.
An immune response with both cellular and humoral components, directed against an allogeneic transplant, whose tissue antigens are not compatible with those of the recipient.
A genus (and common name) in the AGAVACEAE family. It is known for SAPONINS in the root that are used in SOAPS.
The process by which organs are kept viable outside of the organism from which they were removed (i.e., kept from decay by means of a chemical agent, cooling, or a fluid substitute that mimics the natural state within the organism).
Granulated cells that are found in almost all tissues, most abundantly in the skin and the gastrointestinal tract. Like the BASOPHILS, mast cells contain large amounts of HISTAMINE and HEPARIN. Unlike basophils, mast cells normally remain in the tissues and do not circulate in the blood. Mast cells, derived from the bone marrow stem cells, are regulated by the STEM CELL FACTOR.
Adverse functional, metabolic, or structural changes in ischemic tissues resulting from the restoration of blood flow to the tissue (REPERFUSION), including swelling; HEMORRHAGE; NECROSIS; and damage from FREE RADICALS. The most common instance is MYOCARDIAL REPERFUSION INJURY.
The process of losing secretory granules (SECRETORY VESICLES). This occurs, for example, in mast cells, basophils, neutrophils, eosinophils, and platelets when secretory products are released from the granules by EXOCYTOSIS.
Either of the pair of organs occupying the cavity of the thorax that effect the aeration of the blood.
Individuals supplying living tissue, organs, cells, blood or blood components for transfer or transplantation to histocompatible recipients.
A high-molecular-weight plasma protein, produced by endothelial cells and megakaryocytes, that is part of the factor VIII/von Willebrand factor complex. The von Willebrand factor has receptors for collagen, platelets, and ristocetin activity as well as the immunologically distinct antigenic determinants. It functions in adhesion of platelets to collagen and hemostatic plug formation. The prolonged bleeding time in VON WILLEBRAND DISEASES is due to the deficiency of this factor.
A cell-surface ligand involved in leukocyte adhesion and inflammation. Its production is induced by gamma-interferon and it is required for neutrophil migration into inflamed tissue.
Group of hemorrhagic disorders in which the VON WILLEBRAND FACTOR is either quantitatively or qualitatively abnormal. They are usually inherited as an autosomal dominant trait though rare kindreds are autosomal recessive. Symptoms vary depending on severity and disease type but may include prolonged bleeding time, deficiency of factor VIII, and impaired platelet adhesion.
The hollow, muscular organ that maintains the circulation of the blood.
The number of times the HEART VENTRICLES contract per unit of time, usually per minute.
The level of health of the individual, group, or population as subjectively assessed by the individual or by more objective measures.
The transference of a kidney from one human or animal to another.
A heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic need of the body. Heart failure can be caused by structural defects, functional abnormalities (VENTRICULAR DYSFUNCTION), or a sudden overload beyond its capacity. Chronic heart failure is more common than acute heart failure which results from sudden insult to cardiac function, such as MYOCARDIAL INFARCTION.
The property of blood capillary ENDOTHELIUM that allows for the selective exchange of substances between the blood and surrounding tissues and through membranous barriers such as the BLOOD-AIR BARRIER; BLOOD-AQUEOUS BARRIER; BLOOD-BRAIN BARRIER; BLOOD-NERVE BARRIER; BLOOD-RETINAL BARRIER; and BLOOD-TESTIS BARRIER. Small lipid-soluble molecules such as carbon dioxide and oxygen move freely by diffusion. Water and water-soluble molecules cannot pass through the endothelial walls and are dependent on microscopic pores. These pores show narrow areas (TIGHT JUNCTIONS) which may limit large molecule movement.
Granular leukocytes having a nucleus with three to five lobes connected by slender threads of chromatin, and cytoplasm containing fine inconspicuous granules and stainable by neutral dyes.
Transplantation between individuals of the same species. Usually refers to genetically disparate individuals in contradistinction to isogeneic transplantation for genetically identical individuals.
The diffusion or accumulation of neutrophils in tissues or cells in response to a wide variety of substances released at the sites of inflammatory reactions.
Unstable isotopes of gold that decay or disintegrate emitting radiation. Au 185-196, 198-201, and 203 are radioactive gold isotopes.
A state of prolonged irreversible cessation of all brain activity, including lower brain stem function with the complete absence of voluntary movements, responses to stimuli, brain stem reflexes, and spontaneous respirations. Reversible conditions which mimic this clinical state (e.g., sedative overdose, hypothermia, etc.) are excluded prior to making the determination of brain death. (From Adams et al., Principles of Neurology, 6th ed, pp348-9)
The volume of BLOOD passing through the HEART per unit of time. It is usually expressed as liters (volume) per minute so as not to be confused with STROKE VOLUME (volume per beat).
Painful menstruation.
Small pumps, often implantable, designed for temporarily assisting the heart, usually the LEFT VENTRICLE, to pump blood. They consist of a pumping chamber and a power source, which may be partially or totally external to the body and activated by electromagnetic motors.
Hospitals which provide care for a single category of illness with facilities and staff directed toward a specific service.
It is a form of protection provided by law. In the United States this protection is granted to authors of original works of authorship, including literary, dramatic, musical, artistic, and certain other intellectual works. This protection is available to both published and unpublished works. (from Circular of the United States Copyright Office, 6/30/2008)
A single-chain polypeptide derived from bovine tissues consisting of 58 amino-acid residues. It is an inhibitor of proteolytic enzymes including CHYMOTRYPSIN; KALLIKREIN; PLASMIN; and TRYPSIN. It is used in the treatment of HEMORRHAGE associated with raised plasma concentrations of plasmin. It is also used to reduce blood loss and transfusion requirements in patients at high risk of major blood loss during and following open heart surgery with EXTRACORPOREAL CIRCULATION. (Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Englewood, CO, 1995)

Association between primary graft dysfunction among lung, kidney and heart recipients from the same multiorgan donor. (1/98)

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Impact of human donor lung gene expression profiles on survival after lung transplantation: a case-control study. (2/98)

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Late primary graft dysfunction after lung transplantation and bronchiolitis obliterans syndrome. (3/98)

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Plasma cytokines and chemokines in primary graft dysfunction post-lung transplantation. (4/98)

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Participation of autophagy in the initiation of graft dysfunction after rat liver transplantation. (5/98)

Better ways to prevent the cold ischemia-warm reperfusion (CI/WR) injury associated with liver transplantation are needed, and many investigations have focused on the molecular mechanisms of this injury. However, the mechanisms reported to date are controversial and no improvement in therapy has resulted. Here, using prolonged CI and orthotopic transplantation of rat liver grafts, we found that the CI/WR injury was closely associated with autophagy. By 15 minutes after the start of WR, small masses of hepatocytes that possessed abundant autophagosomes and autolysosomes frequently dissociated from the hepatic cords and obstructed the sinusoid, causing massive necrosis of hepatocytes within 2 hours. The cell masses included TUNEL-positive nuclei without caspase-3 and -7 activation. Autophagy suppression with the phosphatidylinositol 3-kinase (PI3K) inhibitors, wortmannin or LY294002, reduced both liver damage and the mortality rate of recipient rats. To elucidate the downstream mechanisms of this autophagic pathway, liver grafts were treated with aspartic and cysteine proteinase inhibitors, pepstatin and leupeptin. This treatment also significantly improved the survival rate of recipient rats. These data suggest that autophagy-associated hepatocyte death triggers liver graft dysfunction. The protective effects of suppressing autophagy may suggest new ways to prevent CI/WR injury of the liver.  (+info)

Does anaesthetic management affect early outcomes after lung transplant? An exploratory analysis. (6/98)

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Concurrent Kaposi's sarcoma, tuberculosis, and allograft dysfunction in a renal transplant patient. (7/98)

The major long-term complications of renal transplantation (RT) include cardio-vascular disease, opportunistic infections, malignancies, and chronic allograft nephropathy. Long-term complications are generally considered as those occurring more than 1 year post trans-plantation; however, some of the complications can occur earlier. We present a 58-year-old man who presented with multiple complications of RT concurrently and relatively early post trans-plantation including Kaposi's sarcoma, tuberculosis and allograft dysfunction.  (+info)

Soluble p-selectin and the risk of primary graft dysfunction after lung transplantation. (8/98)

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Implementation of an evidence-based guideline for managing respiratory and hemodynamic status is feasible and safe and was associated with reduction in severity of primary graft dysfunction. Further studies are required to determine whether such a guideline would lead to a consistent reduction in severity of primary graft dysfunction at other institutions. Creation of a protocol for postoperative care provides a template for further studies of novel therapies or management strategies for primary graft dysfunction ...
TY - JOUR. T1 - Plasma intercellular adhesion molecule-1 and von Willebrand factor in primary graft dysfunction after lung transplantation. AU - Covarrubias, M.. AU - Ware, L. B.. AU - Kawut, S. M.. AU - De Andrade, J.. AU - Milstone, A.. AU - Weinacker, A.. AU - Orens, J.. AU - Lama, V.. AU - Wille, K.. AU - Bellamy, S.. AU - Shah, C.. AU - Demissie, E.. AU - Christie, J. D.. PY - 2007/11. Y1 - 2007/11. N2 - Primary graft dysfunction (PGD), a form of acute lung injury occurring within 72 h following lung transplantation, is characterized by pulmonary edema and diffuse alveolar damage. We hypothesized that higher concentrations of intercellular adhesion molecule-1 (ICAM-1) and von Willebrand factor (vWF) would be associated with the occurrence of PGD. A total of 128 lung transplant recipients among 7 lung transplant centers were enrolled in a multicenter, prospective, cohort study. Blood specimens were collected preoperatively and at 6, 24, 48 and 72 h following lung transplantation. The primary ...
TY - JOUR. T1 - Aprotinin in lung transplantation is associated with an increased incidence of primary graft dysfunction. AU - Marasco, Silvana F.. AU - Pilcher, David. AU - Oto, Takahiro. AU - Chang, Wenly. AU - Griffiths, Anne. AU - Pellegrino, Vince. AU - Chan, Justin. AU - Bailey, Michael. N1 - Copyright: Copyright 2011 Elsevier B.V., All rights reserved.. PY - 2010/2. Y1 - 2010/2. N2 - Objective: Aprotinin has been widely used to reduce bleeding and transfusion requirements in cardiac surgery and in lung transplantation. A recent study found a significant reduction in severe (grade III) primary graft dysfunction (PGD) in lung transplantation where aprotinin had been used. However, recently, concerns regarding the safety of aprotinin have been raised, and the future use of aprotinin is uncertain. In our institution, aprotinin has been widely used in cardiac surgery and transplantation. We decided to review our lung transplant caseload to investigate the impact of aprotinin on PGD and ...
TY - JOUR. T1 - Clinical risk factors for primary graft dysfunction after lung transplantation. AU - Diamond, Joshua M.. AU - Lee, James C.. AU - Kawut, Steven M.. AU - Shah, Rupal J.. AU - Localio, A. Russell. AU - Bellamy, Scarlett L.. AU - Lederer, David J.. AU - Cantu, Edward. AU - Kohl, Benjamin A.. AU - Lama, Vibha N.. AU - Bhorade, Sangeeta M.. AU - Crespo, Maria. AU - Demissie, Ejigayehu. AU - Sonett, Joshua. AU - Wille, Keith. AU - Orens, Jonathan. AU - Shah, Ashish S.. AU - Weinacker, Ann. AU - Arcasoy, Selim. AU - Shah, Pali D.. AU - Wilkes, David S.. AU - Ware, Lorraine B.. AU - Palmer, Scott M.. AU - Christie, Jason D.. PY - 2013/3/1. Y1 - 2013/3/1. N2 - Rationale: Primary graft dysfunction (PGD) is the main cause of early morbidity and mortality after lung transplantation. Previous studies have yielded conflicting results for PGD risk factors. Objectives: We sought to identify donor, recipient, and perioperative risk factors for PGD. Methods: Weperformeda 10-center prospective ...
TY - JOUR. T1 - A panel of lung injury biomarkers enhances the definition of primary graft dysfunction (PGD) after lung transplantation. AU - Shah, Rupal J.. AU - Bellamy, Scarlett L.. AU - Localio, A. Russell. AU - Wickersham, Nancy. AU - Diamond, Joshua M.. AU - Weinacker, Ann. AU - Lama, Vibha N.. AU - Bhorade, Sangeeta. AU - Belperio, John A.. AU - Crespo, Maria. AU - Demissie, Ejigayehu. AU - Kawut, Steven M.. AU - Wille, Keith M.. AU - Lederer, David J.. AU - Lee, James C.. AU - Palmer, Scott M.. AU - Orens, Jonathan. AU - Reynolds, John. AU - Shah, Ashish. AU - Wilkes, David S.. AU - Ware, Lorraine B.. AU - Christie, Jason D.. PY - 2012/9. Y1 - 2012/9. N2 - Background: We aimed to identify combinations of biomarkers to enhance the definition of primary graft dysfunction (PGD) for translational research. Methods: Biomarkers reflecting lung epithelial injury (soluble receptor for advance glycation end products [sRAGE] and surfactant protein-D [SP-D]), coagulation cascade (plasminogen ...
TY - JOUR. T1 - Cell-Free Hemoglobin-mediated Increases in Vascular Permeability. A Novel Mechanism of Primary Graft Dysfunction and a New Therapeutic Target. AU - Shaver, Ciara M.. AU - Wickersham, Nancy. AU - McNeil, J. Brennan. AU - Nagata, Hiromasa. AU - Sills, Gillian. AU - Kuck, Jamie L.. AU - Janz, David R.. AU - Bastarache, Julie A.. AU - Ware, Lorraine B.. PY - 2017/9/1. Y1 - 2017/9/1. N2 - RATIONALE: Cell-free hemoglobin (CFH) is a potent oxidant associated with poor clinical outcomes in a variety of clinical settings. Recent studies suggest that acetaminophen (APAP), a specific hemoprotein reductant, can abrogate CFH-mediated oxidative injury and organ dysfunction. Preoperative plasma CFH levels are independently associated with primary graft dysfunction (PGD) after lung transplant ( 1 ).OBJECTIVES: Our objectives were to determine whether CFH would increase lung vascular permeability in the isolated perfused human lung and whether APAP would limit these effects.METHODS: Human lungs ...
Background. Enzymatic activity inhibition of CD26/dipeptidylpeptidase IV (CD26/DPP IV) attenuated short-term post-Tx (transplantation) ischemia-reperfusion injury after 18-hr-ischemia. Here, we investigated the effect of intragraft CD26/DPP IV catalytic inhibition on primary graft dysfunction during 7 day post-Tx, following extended ischemia. Methods. A syngeneic rat (LEW [Lewis abstract]) orthotopic lung Tx model was used, grafts exposed to 18 hr cold ischemia before Tx. Controls were flushed and preserved in Perfadex, and harvested after 1 day (CON1) or 7 day (CON7) post-Tx. Investigational groups IN1, IN3, and IN7 grafts were perfused with and stored in Perfadex + inhibitor (AB192) and harvested at 1, 3, and 7 days post-Tx, respectively. Blood gas analysis, peak airway pressure (PAwP), wet/dry weight ratio, myeloperoxidase thiobarbituric acid reactive substances (TBARS), and staining for vasoactive intestinal peptide (VIP) were analyzed. Results. IN1 versus CON1 showed preserved histology, ...
OBJECTIVES: To evaluate the value of cardiac power output index (CPOi) in predicting severe primary graft dysfunction (PGD) after heart transplantation (defined as mechanical circulatory support [MCS] and/or mortality ,30 days after transplant).. DESIGN: Observational cohort study.. SETTING: A heart transplant center in the United Kingdom.. PARTICIPANTS: Consecutive patients who underwent heart transplantation from January 2014 to December 2019 (n = 160). Twenty patients were excluded, as MCS was instituted immediately after transplant.. INTERVENTIONS: None.. MEASUREMENTS AND MAIN RESULTS: Hemodynamic data on return to the intensive care unit (time 0, T0) and at 6 hours (T6) were collected to calculate CPOi at both points in 140 consecutive patients-22 patients developed severe PGD. The CPOi at T0 correlated with donor-recipient predicted heart mass and inversely with inotrope score. Patients who developed severe PGD had significantly lower CPOi at T0 and T6. The areas under the receiver ...
Primary graft dysfunction (PGD), as characterized by pulmonary infiltrates and high oxygen requirements shortly after reperfusion, is the major cause of early morbidity and mortality after lung transplantation. Donor, recipient and allograft-handling factors are thought to contribute, although new insights regarding pathogenesis are needed to guide approaches to prevention and therapy. Mast cells have been implicated in ischemic tissue injury in other model systems and in allograft rejection, leading to the hypothesis that mast cell degranulation contributes to lung injury following reperfusion injury. We tested this hypothesis in a mouse model of PGD involving reversible disruption of blood flow to one lung. Metrics of injury included albumin permeability, plasma extravasation, lung histopathology, and mast cell degranulation. Responses were assessed in wild-type (Kit +/+ ) and mast cell-deficient (Kit W-sh/W-sh ) mice. Because mouse
2016 Elsevier Inc. Background Primary graft dysfunction (PGD) is a frequent complication after cardiac transplantation and remains one of the leading causes of mortality in these patients. The objective of this case-control study is to identify donor and surgical procedures factors associated with PGD, and further guide possible strategies to prevent PGD. Methods Retrospective analysis of the medical records of patients who underwent cardiac transplantation at Memorial Hermann Hospital at Texas Medical Center between October 2012 and February 2015. Results The study population included 99 patients, of which 18 developed PGD. Univariate analysis of donor characteristics revealed opioid use (P =.049) and death owing to anoxia (P =.021) were associated with PGD. The recipient/donor blood type match AB/A was significantly associated with PGD (P =.031). Time from brain death to aortic cross clamp (TBDACC) of ≥3 and ≥5 days were also found to be associated with PGD (P =.0011 and.0003, ...
Acute lung injury within 72 hours of lung transplantation, termed Primary Graft Dysfunction (PGD), is a major cause of early post-transplant morbidity and morta...
PubMed journal article Primary graft dysfunction and long-term pulmonary function after lung transplantatio were found in PRIME PubMed. Download Prime PubMed App to iPhone or iPad.
Primary graft dysfunction (PGD) is a major cause of early mortality after lung transplant. We aimed to define objective estimates of PGD risk based on readily available clinical variables, using a prospective study of 11 centers in the Lung Transplant Outcomes Group (LTOG). Derivation included 1255 subjects from 2002 to 2010; with separate validation in 382 subjects accrued from 2011 to 2012. We used logistic regression to identify predictors of grade 3 PGD at 48/72 h, and decision curve methods to assess impact on clinical decisions. ...
The survival associated with double lung transplantation (LTx) is 7.1 years, however, closer inspection of recipient pre-LTx disease demonstrates that survival amongst COPD patients (related to cigarette smoke [CS] exposure) is amongst the worst at 5.5 years, as compared to 8.9 years in cystic fibrosis patients. A number of risk factors are thought to lead to this observed inferior outcome, chief amongst these, are pre-LTx diagnosis, recipient and donor age, and donor CS history. Indeed, CS exposure in either the recipients or donors has been linked with increased rates of severe primary graft dysfunction, acute rejection (AR), and ultimately earlier graft failure. The goal of these proposed studies is to demonstrate evidence that CS exposure, either donor or recipient, alters the local lung-specific immune environment in such a way as to predispose to exacerbated ischemia-reperfusion injury (IRI), with a resultant worsening of AR. We first examined the role of CS exposure on the lung ...
The incidence of primary graft dysfunction (PDF) after LT is approximately 25% within a range of 9.3 to 43.7% based on different definitions characterizing PDF [1-5]. Initial non-function (INF) develops in up to 6% of all considered cases and requires urgent retransplantation [6].. Risk factors are prolonged cold ischemia time or higher degree of graft steatosis and subsequent development of severe hepatic ischemia/reperfusion injury (IRI) [5, 7]. A cascade of cellular events results in microcirculatory flow disturbance. This may be distinguished as no-flow indicating capillary perfusion failure on the one hand, or reflow-paradox including activation of the leukocyte-endothelium interaction, release of toxic mediators, and impairment of the endothelial barrier on the other hand [8, 9]. There are, obviously, further different factors all contributing to an insufficient function of liver grafts and its detrimental effects on the overall outcome after LT: recipients condition, the donor data, ...
Pain management information for pain medicine healthcare professionals in treating and caring for their patients. Clinical Pain Advisor offers news, case studies and more.
TY - JOUR. T1 - Report of the ISHLT Working Group on Primary Lung Graft Dysfunction part IV. T2 - Recipient-related risk factors and markers. AU - Barr, Mark L.. AU - Kawut, Steven M.. AU - Whelan, Timothy P.. AU - Girgis, Reda. AU - Böttcher, Heidi. AU - Sonett, Joshua. AU - Vigneswaran, Wickii. AU - Follette, David M.. AU - Corris, Paul A.. PY - 2005/10/1. Y1 - 2005/10/1. N2 - The lack of a clear definition of PGD in many large series of lung transplantation, including the ISHLT registry data, hampers the identification of recipient-related risk factors. Concomitant donor-related variables further confound these analyses. Based on the current body of literature, recipient-related risk factors that would require further study before any association can be stated include the type of procedure, the presence of hepatic dysfunction, and pleural adhesions and/or prior surgery, which increase the risk of post-operative bleeding. Additional factors that may confound the clinical picture or possibly ...
Duvoux, C.; Pawlotsky, J.M.; Cherqui, D.; Metreau, J.M.; Fagniez, P.L.; Duval, J.; Dhumeaux, D., 1994: Value of HCV RNA quantitation in diagnosis of acute graft dysfunction after liver transplantation for HCV-related cirrhosis
When citing a chapter of a book, capitalize as for a journal article title (see , Titles); do not use quotation marks. Inclusive page numbers of the chapter should be given (see also , Page Numbers or Chapter Number). 1. Solensky R. Drug allergy: desensitization and treatment of reactions to antibiotics and aspirin. In: Lockey P, ed. Allergens and Allergen Immunotherapy. 3rd ed. New York, NY: Marcel Dekker; 2004:585-606. 2. Yashiro M, Yanagawa H. Database construction for information on patients with Kawasaki disease. In: Yanagawa H, Nakamura Y, Yashiro M, Kawasaki T, eds. Epidemiology of Kawasaki Disease: A 30-Year Achievement.
Primary graft dysfunction (PGD) is the most common cause of early morbidity and mortality following lung transplant and is characterized by acute lung injury and capillary leak leading to an increase in extravascular lung water index (ELWI) and impaired graft function. PGD has many features in common with acute respiratory distress syndrome (ARDS). PGD may be life-threatening and can also lead to impaired long term lung function. In ARDS, a restrictive fluid strategy has been associated with an improvement in lung function and outcomes. Accurate methods of evaluating, quantifying and guiding the hemodynamic / fluid management and limiting the extent of ELWI that accumulates in the setting of PGD are lacking. Using transpulmonary thermodilution to estimate ELWI and the pulmonary permeability index (PPI) represents a novel approach to fluid management, which has been used in patients with ARDS, but to date not in the transplant setting. To determine if these measurements may better guide the ...
TY - JOUR. T1 - Clinical application of an extracellular phosphate-buffered solution (EP-TU) for lung preservation. T2 - Preliminary results of a Japanese series. AU - Okada, Yoshinori. AU - Matsumura, Yuji. AU - Date, Hiroshi. AU - Bando, Toru. AU - Oto, Takahiro. AU - Sado, Tetsu. AU - Hoshikawa, Yasushi. AU - Noda, Masafumi. AU - Oishi, Hisashi. AU - Kondo, Takashi. PY - 2012/1. Y1 - 2012/1. N2 - Purpose: We evaluated the effect of an extracellular phosphate-buffered lung preservation solution (EP-TU solution) on acute postoperative graft function and recipient survival in a Japanese series of cadaveric lung transplantation. Methods: The subjects were ten patients who received lung grafts preserved with EP-TU solution at three of four designated lung transplant centers between 2000 and 2005. Three of the patients underwent single lung transplantation and seven underwent bilateral lung transplantation. Postoperative graft function was evaluated by primary graft dysfunction (PGD) grade (0-3), ...
BACKGROUND: In an era of increasing ex vivo lung perfusion (EVLP) use, it remains important to describe what outcomes can be achieved without EVLP, by taking an aggressive approach to donor use to maximize lung transplantation. METHODS: Data for all lung transplant donor referrals to the Alfred Hospital in Melbourne, Australia were collected for 2012 to 2013. Donor variables were analyzed and calculated into a previously validated lung donor score. Lung transplant recipient outcome data included the following: primary graft dysfunction; duration of mechanical ventilation; need for cardiopulmonary bypass extracorporeal membrane oxygenation; intensive care and hospital length of stay; 30-day, 1-year, and 3- to 4-year survival rates; rates of acute rejection and chronic lung allograft dysfunction; and peak and 12-month lung function (forced expiratory volume in 1 second ...
We are extremely pleased to enter into this strategic partnership with Lung Rx, said Wade A. Lange, President and CEO of ImmuneWorks. ImmuneWorks and Lung Rx share a common goal of addressing the needs of patients who are suffering from life-threatening pulmonary diseases, that makes Lung Rx a perfect partner for us.. Founded by Indiana University School of Medicine scientists, Michael Klemsz, PhD, and David Wilkes, MD, and Ronald Meeusen, PhD, Managing Partner of MidPoint Food & Ag Fund, ImmuneWorks is developing a treatment for idiopathic pulmonary fibrosis (IPF), which kills more than 40,000 people each year and for primary graft dysfunction (PGD), which is a leading cause of morbidity and mortality following lung transplantation. ImmuneWorks first product, IW-001 (bovine type V collagen, oral solution) is currently under review by the US Food and Drug Administration in anticipation of first human testing in 2010.. We are delighted to form this partnership with ImmuneWorks in these areas ...
Type V collagen may play a role in graft rejection following lung transplants (See Review: Sumpter TL, Wilkes DS. Role of autoimmunity in organ allograft rejection: a focus on immunity to type V collagen in the pathogenesis of lung transplant rejection. Am J Physiol Lung Cell Mol Physiol 2004; 286: L1129-39). It has been shown that oral tolerance induction by oral administration of type V collagen prevents lung allograft rejection in animal models, and is expected to be used for humans. Importantly, it has been reported that patients who were previously sensitized by type V collagen and positive for type V collagen-DTH reactions tend to develop idiopathic pulmonary fibrosis (58.8%, 10/17) compared to patients who were negative for the DTH reaction (15.8%, 6/38) (Bobadilla JL, Love RB, Jankowska-Gan E, Xu Q, et al. Th-17, monokines, collagen type V, and primary graft dysfunction in lung transplantation. Am J Respir Crit Care Med 2008; 177: 660-8).. Type V and Type XI Collagen ...
Objectives : VAC therapy is actually used routinely in infected thoracic wound. We reported in this presentation an original use in thoracic surgery: VAC therapy to maintain sterile an unclose chest wall in lung transplant after massive bleeding managed with damage control surgery or after brutal lung oedema.. Methods : Lung transplant is an uncommun part in thoracic surgery, performed in specialized center. Surgeons are confronted to major bleeding due to patient background and the frequent use of ECMO in per-operating and post-operative. Furthermore lung tranplants are exposed to a major oedema included in the primary graft dysfunction. We decided to report an originally case series of management of catastrophic bleeding and lung oedema in lung transplantation.. Results : Between January 2014 and august 2016, 100 bilateral lung transplant were performed in our unit. 19 patients were re-operated. Fourteen of them for postoperative hemothorax or bleeding, 4 for anastomotic leakage and 1 for a ...
Objective In lung transplantation, unexpected pulmonary emboli, including thrombi and fat, have been observed with high probability and are associated with potential primary graft dysfunction. We...
Background: Ischemia/reperfusion (I/R) injury is an important cause of renal graft dysfunction. Increases in cold and warm ischemia times lead to a higher risk of early posttransplant complications including delayed graft function and acute rejection. Moreover, prolonged cold ischemia is a predictor of long-term graft loss in kidney transplant patients. Methods: Darbepoetin alfa (DA) and carbamylated nonerythropoietic derivative of erythropoietin (CEPO) protective effects were evaluated in a model of I/R injury after kidney transplantation in both syngeneic and allogeneic combinations. The effects of wortmannin (phosphorylated Akt [p-Akt] inhibitor) administration were also investigated. Serum creatinine was evaluated at 16, 24, 48 hr and at 4 and 7 days posttransplant. Animals were killed 24 hr or 7 days after transplant and kidneys were processed for histological analysis, immunohistochemistry assessment of erythropoietin receptor (EPOR) and β-common chain receptor expression, granulocyte ...
Figure S1: Low donor lung SP-A mRNA-level associates with decreased survival. The graph shows the survival curves for recipients of double lung transplant excluding patient with ILD. This ad hoc analysis was to address the possible selection bias that is shown in Table S1 with greater percentage of ILD and single lung transplant in the study cohort. Lung transplant patients that received lung allografts with low levels of SP-A mRNA expression prior to implantation had significantly reduced survival. The number of patients in each group is indicated in brackets. The x-axis represents the cumulative survival. Circles indicate the censored patients within the analysis. ...
Liver graft dysfunction can deteriorate to complete organ failure and increases perioperative morbidity and mortality after liver transplantation. Therapeutic strategies reducing the rate of graft dysfunction are of current clinical relevance. One approach is the systemic application of prostaglandins, which were demonstrated to be beneficial in reducing ischemia-reperfusion injury. Preliminary data indicate a positive effect of prostacyclin analogue iloprost on allograft viability after liver transplantation. The objective of the study is to evaluate the impact of iloprost in a multi-center trial.
Key Points. Acquired aplastic anemia is a T-cell-mediated autoimmune bone marrow aplasia, without a known etiologic trigger.Clonal expansion of CD8+ effector T
Genetic testing of embryos in IVF is now under low PGD cost in Kolkata, India. Call us at +91 766-866-6633 for embryo biopsy and testing for PGD in Kolkata.
TY - JOUR. T1 - Early primary graft failure after a pediatric heart transplant and successful rescue with plasmapheresis, immunoglobulins, and alemtuzumab. AU - Raj, Shashi. AU - Ruiz, Phillip. AU - Rusconi, Paolo. PY - 2017/1/1. Y1 - 2017/1/1. N2 - Early primary graft failure after pediatric orthotopic heart transplantation (OHT) has a high mortality rate and can occur due to several causes including but not limited to prolonged graft ischemia time, suboptimal preimplant myocardial preservation, hyperacute rejection, and maladaptation of the graft to the hosts hemodynamic status. Mechanical circulatory support with either extracorporeal membrane oxygenation (ECMO) or ventricular assist device has been used for the rescue of primary graft failure in pediatric patients after heart transplant. Cardiac arrest before ECMO initiation in these patients is associated with adverse neurologic outcome although those surviving to hospital discharge generally have excellent long-term outcome. We report a ...
Purpose: Primary graft dysfunction (PGD) is a form of acute lung injury driven by ischemia-reperfusion mediated damage. An increase in plasma complement proteins - specifically C4a and C5a - is associated with PGD, and an increase in C3a and C5a levels is associated with mortality, independent of PGD. However, serum levels appear to be high at baseline post-lung transplantation (LTx); and hence, make it harder to distinguish patients at risk. Given that PGD manifests as an acute lung injury, we hypothesized that local complement activation would help identify those who go on to develop PGD post-LTx.. *Methods: Bronchoalveolar lavage (BAL) specimens were obtained from recipients at 2 and 24h post-LTx. PGD was scored based on the consensus definition at 24, 48 and 72h post-LTx by an investigator blinded to the results. Complement activation proteins were measured using ELISA. Specifically, levels of C4d, indicating classical/lectin pathway activation and soluble C5b-9 (sC5b-9), a marker of ...
Eculizumab: This humanized monoclonal antibody against complement C5 ultimately prevents the formation of C5-9 membrane attack complex and generation of prothrombotic C5a.. Plasma exchange: Plasma exchange can be used to remove the mutated protein and replace them with normal proteins in patients who do not respond to Eculizumab. Transplant patients with auto-antibodies against complement factor H have been successfully treated with plasma- exchange, rituximab and high dose steroids.. Liver- kidney transplantation: There have been some case reports of combined liver and kidney transplantation, which has been successful in treating HUS in patients with complement factor H mutation.. It is important to identify the gene mutation that led to atypical HUS in every patient who is evaluated for kidney transplantation and has a history of atypical HUS, in order to estimate the risk of recurrence and plan eventual prevention therapy. The knowledge of the mutation would also allow appropriate ...
Elliott, Adrian, Skowno, Justin, Prabhu, Mahesh, Noakes, Timothy and Ansley, Les (2015) Evidence of cardiac functional reserve upon exhaustion during incremental exercise to determine VO2max. British Journal of Sports Medicine, 49 (2). pp. 128-132. ISSN 0306-3674 Ong, Lay Ping, Tristan, Z., Prabhu, Mahesh, Parry, Gareth and Clark, Stephen (2014) Prolonged Intensive Care Unit Stay after Bilateral Lung Transplantation - Late Mortality & Functional Outcome? The Journal of Heart and Lung Transplantation, 33 (S4). S294. ISSN 1053 2498 Andreasson, Anders, Karamanou, Danai, Perry, John, Perry, Audrey, Ӧzalp, Faruk, Butt, Tanveer, Morley, Katie, Walden, Hannah, Clark, Stephen, Prabhu, Mahesh, Corris, Paul, Gould, Kate, Fisher, Andrew and Dark, John (2014) The effect of ex vivo lung perfusion on microbial load in human donor lungs. The Journal of Heart and Lung Transplantation, 33 (9). pp. 910-916. ISSN 1053-2498 Dark, John, Karamanou, Danai, Clark, Stephen, Prabhu, Mahesh, Watson, B., Corris, Paul and ...
Warnecke G, Van Raemdonck D, Smith MA, Massard G, Kukreja J, Rea F, Loor G, De Robertis F, Nagendran J, Dhital KK, Moradiellos Díez FJ, Knosalla C, Bermudez CA, Tsui S, McCurry K, Wang IW, Deuse T, Lesèche G, Thomas P, Tudorache I, Kühn C, Avsar M, Wiegmann B, Sommer W, Neyrinck A, Schiavon M, Calabrese F, Santelmo N, Olland A, Falcoz PE, Simon AR, Varela A, Madsen JC, Hertz M, Haverich A, Ardehali A. Normothermic ex-vivo preservation with the portable Organ Care System Lung device for bilateral lung transplantation (INSPIRE): a randomised, open-label, non-inferiority, phase 3 study. Lancet Respir Med. 2018 05; 6(5):357-367 ...
The study population characteristics raise the need to establish a treatment regime that assures suitable intensity immunosuppression to avoid the appearance of rejection episodes, but minimizes the doses to prevent over-immunosuppression in a population with a theoretic minor immune response.. On the other hand, the delay in the introduction of calcineurin inhibitors will prevent increasing the risk of early graft dysfunction allowing the highest post-transplant renal recovery in organs with less operative mass and greater sensibility to the nephrotoxic effect of these drugs.. The results of several studies confirm the goodness of regimes that include low doses of calcineurin inhibitors, delay their introduction or avoid them.. Nevertheless, although it is standard practice to evaluate the effectiveness of the regimes for a time to assure, with certainty, the response to the treatments, these follow-ups are still relatively short to assure the efficacy for a long-term study and to detect the ...
The basis for increased mortality after heart transplantation in African Americans and other non-Caucasian racial groups is poorly defined. We hypothesized that increased risk of adverse events is driven by biologic factors. To test this hypothesis in the Invasive Monitoring Attenuation through Gene Expression (IMAGE) study, we determined whether the event rate of the primary outcome of acute rejection, graft dysfunction, death, or retransplantation varied by race as a function of calcineurin inhibitor (CNI) levels and gene expression profile (GEP) scores.We determined the event rate of the primary outcome, comparing racial groups, stratified by time after transplant. Logistic regression was used to compute the relative risk across racial groups, and linear modeling was used to measure the dependence of CNI levels and GEP score on race.In 580 patients monitored for a median of 19 months, the incidence of the primary end point was 18.3% in African Americans, 22.2% in other non-Caucasians, and ...
Twenty children with a median age of 20 months (1.5-185) and a male/female sex ratio of 1.5 underwent DW-MRI after CA with a median delay of 3 days (1-7). Aetiologies of CA were (i) asphyxia (n = 10), (ii) haemodynamic (n = 5) or (iii) unknown (n = 5). With regard to DW-MRI findings, the unfavourable outcome group (n = 8) was associated with cerebral cortex (p = 0.02) and basal ganglia (p = 0.005) lesions, with a larger number of injured brain regions (p = 0.001) and a global decrease in measured ADC signal (p = 0.008). Normal DW-MRI (n = 5) was exclusively associated with the favourable outcome group (n = 12).. ...
Airway complications following lung transplantation remain a significant cause of morbidity and mortality. The management of bronchial complications in Bronchus Intermedius (BI) is challenging due to the location of right upper bronchus. The aim of this study was to analyze the results of BI Montgomery T-tube stent in a consecutive patients with lung transplantations. Between January 2007 and December 2010, 132 lung transplantations were performed at Foch Hospital, Suresnes, France. All the patients who had BI Montgomery T-tube after lung transplantation were included in this retrospective study. The demographic and interventional data and also complications were recorded. Out of 132 lung transplant recipients, 12 patients (9 male and 3 female) were entered into this study. The indications for lung transplantation were: cystic fibrosis 8 (67%), emphysema 3 (25%), and idiopathic pulmonary fibrosis 1 (8%). Most of the patients (83%) had bilateral lung transplantation. The mean interval between lung
Fingerprint Dive into the research topics of Thrombotic microangiopathy caused by severe graft dysfunction after living donor liver transplantation: Report of a case. Together they form a unique fingerprint. ...
TY - JOUR. T1 - Reconstruction of pulmonary artery with donor aorta and autopericardium in lung transplantation. AU - Noda, Masafumi. AU - Okada, Yoshinori. AU - Saiki, Yoshikatsu. AU - Sado, Tetsu. AU - Hoshikawa, Yasushi. AU - Endo, Chiaki. AU - Sakurada, Akira. AU - Maeda, Sumiko. AU - Oishi, Hisashi. AU - Kondo, Takashi. PY - 2013/7/1. Y1 - 2013/7/1. N2 - A 44-year-old man with Eisenmengers syndrome due to ventricular septal defect (VSD) was listed for lung transplantation. The patients condition was complicated by a giant pulmonary artery (PA) aneurysm. Concurrent VSD closure and total reconstruction of the recipient PA with the donor aorta were planned. When the patient underwent bilateral lung transplantation, the aortic graft obtained turned out to be too short to complete the reconstruction. A PA graft made of the recipients pericardium was successfully interposed between the donors PA and the donors aortic graft.. AB - A 44-year-old man with Eisenmengers syndrome due to ...
Lung Transplantation may be suitable for those patients, physically eligible to undergo a major transplant operation.. In IPF patients, lung transplantation reduces the risk of death by 75% as compared with patients who remain on the waiting list.. Since the introduction of the lung allocation score (LAS), which prioritizes transplant candidates based on survival for lung transplantation in the USA.. Symptomatic patients with IPF younger than 65 years of age and with a body mass index (BMI) ≤ 26kg/m² should be referred for lung transplantation, but there are no clear data to guide the precise timing for LT.. Bilateral lung transplantation is superior to single lung transplantation in patients with IPF ...
Birch, Jodie, Sunny, Syba, Hester, Katy, Parry, Gareth, Gould, F. Kate, Dark, John, Clark, Stephen, Meachery, Gerard, Lordan, James, Fisher, Andrew, Corris, Paul and De Soyza, Anthony (2018) Outcomes of lung transplantation in adults with bronchiectasis. BMC Pulmonary Medicine, 18. ISSN 1471-2466 Sithamparanathan, Sasiharan, Thirugnanasothy, Logan, Clark, Stephen, Dark, John, Fisher, Andrew, Gould, Kate, Hasan, Asif, Lordan, James, Meachery, Gerard, Parry, Gareth and Corris, Paul (2016) Observational study of lung transplant recipients surviving 20 years. Respiratory Medicine, 117. pp. 103-108. ISSN 0954-6111 Ong, Lay Ping, Thompson, Emily, Sachdeva, Ashwin, Ramesh, B. C., Muse, Hazel, Wallace, Kirstie, Parry, Gareth and Clark, Stephen (2016) Allogeneic blood transfusion in bilateral lung transplantation: impact on early function and mortality. European Journal of Cardio-Thoracic Surgery, 49 (2). pp. 668-674. ISSN 1010-7940 Ong, Lay Ping, Sachdeva, Ashwin, Ramesh, Bandigowdanapalya Channaiah, ...
This hospital was formerly the Willis F. Pierce Memorial Hospital. It has 2,200 beds and more than 400 staff members with senior (chief and deputy chief) professional titles. Over 65% of the staff holds masters or doctoral degrees. Its number of allogeneic heart transplants performed leads the nation. Its pediatric heart transplantation and heart re-transplantation fill a gap in this field in China. Its technology in liver transplantation heart re-transplantation and bilateral lung transplantation lead the nation.188. Since its Heart Surgery Department conducted the first orthotopic heart transplant in Fujian Province in 1995, it has successfully performed heart transplants for patients with advanced heart disease from more than 30 cities and regions of China. Its specialty ranks among the best in allogeneic heart transplantation, holds 16 first in the country titles, and serves as the base for heart transplantation in China.. It helped more than 40 large hospitals in large cities such as ...
CD8+ T-cell maturation following lung transplantation: the differential impact of CMV and acute rejection.: Studies on persistent viral infections demonstrate t
During the last 20 years, there has been a shift away from combined heart-lung transplantation (HLT) in favor of bilateral lung transplantation. This paradigm shift allowed for the donor heart to be t
BackgroundThe ABO blood group system is clinically important in kidney transplantation, but ABO genotyping fails to attract sufficient attention in some countries and regions. We identified one case of early graft dysfunction due to an ABO genotype mismatch. Here, we performed ABO genotyping in blood samples, analyzed grouping discrepancies, and investigated the weak A subgroup frequency in kidney transplantation candidates.MethodsBlood samples from 302 uremic patients with grouping discrepancies and 356 uremic patients with type A blood were analyzed using standard serologic serotyping techniques. The ABO genotypes and alleles were analyzed by polymerase chain reaction sequence-specific primer (PCR-SSP) and sequence-based typing (PCR-SBT).ResultsAll 302 uremic patients with grouping discrepancies carried weak ABO subgroup alleles and 77.48% carried irregular ABO antibodies. The discrepancy rate between serotyping and genotyping was 42.38%, and the mismatching rate of donor selection according to
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PURPOSE: Humoral immunity is maintained by long lived memory B and plasma cells, both of which arise from the activation and differentiation of naïve
ABSTRACT Objective: The objective of this research was to analyse the effects of overweight and obesity in relation to markers of chronic graft dysfunction (ie dyslipidemia, high blood pressure, and proteinuria), and study their impact on the quality of life of kidney graft recipients in the first-year after transplantation. Material and methods: This study monitored 1500
Within the last decade, antibody-mediated (humoral) rejection continues to be recognized as a typical reason behind graft dysfunction after organ transplantation and a significant determinant for graft loss. and high-affinity storage B cells (6, 7). B cell depleting therapies have already been used to regulate the forming of DSA in transplant recipients (8) but arent generally utilized as maintenance treatment due to the chance of unwanted effects. Predicated buy 918659-56-0 on their pivotal function in regulating humoral immunity it could be postulated that Tfh cells, instead of B cells, could possibly be geared to inhibit the introduction of antibody-mediated anti-donor reactivity. Presently, no Tfh-specific agencies have been examined in stage II or III studies. Several animal research and a small amount of clinical research in body organ transplant recipients possess Thy1 demonstrated the significance of Tfh cells along the way of alloantibody creation (9). The precise ramifications of ...
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"Anti-type V collagen humoral immunity in lung transplant primary graft dysfunction". Journal of Immunology. 181 (8): 5738-47. ...
... in patients with primary nonfunction and other causes of graft dysfunction after liver transplantation in the era of extended ... the patient to receive a re-transplant if the above goal is not achieved MARS Therapy Indication Primary graft dysfunction ... Cell sources now include primary porcine hepatocytes, primary human hepatocytes, human hepatoblastoma (C3A), immortalized human ... Primary biliary cirrhosis (PBC), primary sclerosing cholangitis (PSC) Benign intrahepatic cholestasis (BIC) Biliary Atresia ...
... genetic profiling of embryos prior to implantation Primary graft dysfunction, a complication of organ transplantation Prolonged ...
... and primary graft dysfunction after lung transplant. The most common causes of ARDS are pneumonia, non-pulmonary sepsis, and ... Of the patients who succumb to ARDS, the most common cause of death is septic shock with multi organ dysfunction syndrome. ...
... untranslated region of PTGER4 has been associated with and increase rate of primary graft dysfunction in a multicentered cohort ...
Immunosuppression is the primary determinant of outcome in small bowel transplantation; the risk for graft rejection is ... The common symptom of graft dysfunction, whether due to infection, rejection, or some other condition, is diarrhea. Intestinal ... In a multivisceral graft, the stomach, duodenum, pancreas, and/or colon may be included in the graft. Multivisceral grafts are ... In the most basic and common graft, an isolated intestinal graft, only sections of the jejunum and ileum are transplanted. ...
ISBN 978-0-8044-2229-1. Stanton, Robert J. (1980). Truman Capote: A Primary and Secondary Bibliography (1st ed.). New York: G K ... Overall the stories are noted for involving "sexual anxiety and dysfunction without solidly grounded detail." In 1950, A Tree ... Capote: a Biography (1998) Carroll & Graff. ISBN 978-0-7867-1661-6 p. 85 Bercovitch, Sacvan The Cambridge History of American ... Capote: A Biography (1998) Carroll & Graff. ISBN 978-0-7867-1661-6 p. 224 Bibliography Bercovitch, Sacvan (1999). The Cambridge ...
Staples versus sutures for closing leg wounds after vein graft harvesting for coronary artery bypass surgery PMID 20464762 ... Early versus delayed dressing removal after primary closure of clean and clean-contaminated surgical wounds PMID 26331392 https ... Interventions for sexual dysfunction following treatments for cancer in women PMID 26830050 https://doi.org/10.1002/14651858. ... Interventions with pregnant women, new mothers and other primary caregivers for preventing early childhood caries PMID 31745970 ...
Noradrenaline and its precursor L-DOPS are used for primary autonomic dysfunction by increasing vascular tone. Erythropoietin ... coronary artery bypass graft surgery) for infarction, steroids for adrenal insufficiency, etc...) The best way to determine if ... The primary symptoms of hypotension are lightheadedness or dizziness. If the blood pressure is sufficiently low, fainting ( ... "Diagnosis and Treatment of Primary Adrenal Insufficiency: An Endocrine Society Clinical Practice Guideline". The Journal of ...
A target trough level of 3 ng/mL at 3 months was shown to be beneficial in recipients with pre-transplant renal dysfunction. In ... The experimental use of everolimus in refractory chronic graft-versus-host disease was reported in 2012. Interim phase III ... showed a positive impact on hepatocellular carcinoma (HCC) when everolimus was used as primary immunosuppression starting as ... due to possible early hepatic artery thrombosis and graft loss, use of everolimus in the setting of liver transplantation is ...
These are known as primary BK infections. Although without any clinical symptoms, footprints of BK virus have been detected in ... Quinolone antibiotics: Ciprofloxacin (Cipro) was shown to significantly lower viral loads but no data on survival and graft ... Clinical manifestations include renal dysfunction (seen by a progressive rise in serum creatinine), and an abnormal urinalysis ... of these patients lose their grafts. The onset of nephritis can occur as early as several days post-transplant to as late as 5 ...
In the McIndoe procedure, a skin graft is applied to form an artificial vagina. After the surgery, dilators are still necessary ... Müllerian agenesis (including absence of the uterus, cervix and/or vagina) is the cause in 15% of cases of primary amenorrhoea ... "WNT4 Müllerian aplasia and ovarian dysfunction". Genetics Home Reference. Retrieved 2012-08-18. Ledig S, Brucker S, Barresi G, ... A person with MRKH typically discovers the condition when, during puberty years, the menstrual cycle does not start (primary ...
According to several studies, coronary artery bypass graft surgery has a survival advantage over medical therapy (for ischemic ... Myocardial imaging usually demonstrates left ventricular dilation, severe ventricular dysfunction, and multiple infarctions. ... is often used to differentiate primary from ischemic cardiomyopathy, and as a prognostic indicator. A 2004 study showed the ... 2008). "The myoblast autologous grafting in ischemic cardiomyopathy (MAGIC) trial first randomized Placebo-controlled study of ...
Allogeneic serum eye drops for the treatment of dry eye patients with chronic graft-versus-host disease. J Ocul Pharmacol Ther ... Ramos-Casals M, Tzioufas AG, Stone JH, Siso A, Bosch X. Treatment of primary Sjogren syndrome: a systematic review. JAMA 2010; ... Shimazaki J, Sakata M, Tsubota K. Ocular surface changes and discomfort inpatients with meibomian gland dysfunction. Arch ... Evaluation of lipid layer thickness measurement of the tear film as a diagnostic tool for Meibomian gland dysfunction. Cornea ...
Another is to line the new vagina with a skin graft.[33][34][35] Potential surgical problems: Stenosis (narrowing) of the ... Potential surgical problems: The primary effect of this surgery, not surprisingly, is a drastic reduction in ability to ... though similar women who had not had surgery also report a high rate of sexual dysfunction.[30] ... When a neovagina is made from a segment of bowel, it tends to leak mucus; when made with a skin graft, lubrication is necessary ...
Upon retrieval, the buccal graft is presented to the urethral surgeon, who will then prepare the graft by trimming and removal ... primary selection) availability of autograft tissue from the penis and scrotum (secondary selection) skill level and training ... which could result in erectile dysfunction or loss of tactile sensation of the penis). The area of the defect is evaluated and ... Upon retrieval, the graft is prepared for attachment by trimming and removal of extraneous tissue. The surgeon will create an ...
The grafts are obtained in one or both of the two primary methods of surgical extraction, follicular unit transplantation, ... It may cause gynecomastia, erectile dysfunction and depression. Dutasteride is used off label for male pattern hair loss. There ... Hair transplantation differs from skin grafting in that grafts contain almost all of the epidermis and dermis surrounding the ... Small grafts of naturally-occurring units of one to four hairs, called follicular units, can be moved to balding areas of the ...
Severe side effects include brain dysfunction, low blood cell counts, and lung inflammation. Use in pregnancy will likely ... 2000). "Fludarabine compared with chlorambucil as primary therapy for chronic lymphocytic leukemia". N Engl J Med. 343 (24): ... The profound lymphopenia caused by fludarabine renders patients susceptible to transfusion-associated graft versus host disease ...
Primary Sjögren's syndrome is the combination of dry eyes and xerostomia. Secondary Sjögren's syndrome is identical to primary ... Xerostomia may be a consequence of infection with hepatitis C virus (HCV) and a rare cause of salivary gland dysfunction may be ... Hormonal disorders, such as poorly controlled diabetes, chronic graft versus host disease or low fluid intake in people ... Xerostomia may also result from a change in composition of saliva (from serous to mucous). Salivary gland dysfunction is an ...
This favorable radiographic response could be expected within one year following the procedure - nevertheless, primary graft ... Additionally extramedullary hematopoiesis can result in liver and spleen dysfunction. Cranial nerve dysfunction and neurologic ...
One trial was done to test the efficacy of NAMI-A in female grafted with MCa mammary carcinoma cells. It was determined that, ... Unlike cisplatin, a platinum based drug, it has been shown in-vivo that NAMI-A doesn't inhibit primary tumor growth but ... High levels indicate kidney dysfunction Fever Sensitivity reactions to drug Phlebitis at injection site Blisters on hands and ...
Stents and stent-grafts: Stents are used to provide a scaffold along a segment of diseased vessel. These are available in a ... A variety of interventional oncological treatments for tumors arise: Liver cancer: primary liver tumors such as hepatocellular ... most commonly by atherosclerotic disease The classic symptoms include buttock claudication and erectile dysfunction, with ... An Arteriovenous Graft (AVG) relies on the same principle but bridges the gap between the artery and vein with a medical-grade ...
The first is labeled as "non-scarring." Non-scarring the hair has the ability to regrowth after treatment of the primary ... Small incisions are made and grafts are placed individually according to the amount of hair in each follicle, eyebrows single. ... Posterior blepharitis is usually due to meibomian gland dysfunction.. *Dermatologic conditions: there are multiple types of ...
The incidence of second primary tumors ranges in studies from 9% to 23% at 20 years. Second primary tumors are the major threat ... At higher doses, head and neck radiation is associated with thyroid dysfunction and pituitary axis dysfunction. Chemotherapy in ... The defect is typically covered/improved by using another part of the body and/or skin grafts and/or wearing a prosthesis. ... non-primary source needed] Although early-stage head and neck cancers (especially laryngeal and oral cavity) have high cure ...
The primary part of the procedure can often be carried out immediately following the mastectomy. As with many other surgeries, ... The risk of dysfunction is higher among women who have breast reconstruction surgery. Some methods have specific side effects. ... The use of acellular human or animal dermal grafts have been described as an onlay patch to increase coverage of the implant ... More than half of women treated for breast cancer develop upper quarter dysfunction, including limits on how well they can move ...
Most patients with excoriation disorder report having a primary area of the body that they focus their picking on, but they ... Damage from picking can be so severe as to require skin grafting. Severe picking can cause epidermal abscesses. Severe cases of ... Thus, excoriation disorder could result from a dysfunction in the dopamine reward functions. There may be another neurological ... Excoriation disorder occurs as the primary disorder and not as a subset of a larger disorder. Excoriation disorder has well- ...
The primary documented driver of this process is oxidized lipoprotein particles within the wall, beneath the endothelial cells ... 2011). "Endothelial (dys)function: the target of physical exercise for prevention and treatment of cardiovascular disease". J. ... Coronary artery bypass grafting without manipulation of the ascending aorta has demonstrated reduced rates of postoperative ... Taylor F, Huffman MD, Macedo AF, Moore TH, Burke M, Davey Smith G, Ward K, Ebrahim S (January 2013). "Statins for the primary ...
The function of this protein is not known and it has no primary sequence similarity to any other protein or structural domain ... Exocrine pancreatic dysfunction: Pancreatic exocrine insufficiency arises due to a lack of acinar cells that produce digestive ... However, SDS patients have an elevated occurrence of BMT-related adverse events, including graft-versus-host disease (GVHD) and ... Shwachman H, Diamond LK, Oski FA, Khaw KT (1964). "The syndrome of pancreatic insufficiency and bone marrow dysfunction". J ...
... slight increase in white blood count and graft-site tenderness. Three types of graft rejection may occur: hyperacute rejection ... Acute rejection is the most common and the primary target of immunosuppressive agents. Acute rejection is usually seen within ... liver dysfunction. Since the procedure carries relatively high risks, is resource-intensive, and requires major life- ... for those with primary liver cancer or secondary spread to the liver, the medical team will likely rely heavily on the opinion ...
Preventive strategies to avoid primary graft dysfunction (PGD) have been focused on better donor choice and maintenance, heart ... Extracorporeal life support (ECLS) should be installed early, before the occurrence of multiorgan dysfunction or prior to ... Primary graft dysfunction is the main cause of early mortality after heart transplantation (HT). ... 2. Primary graft dysfunction. 2.1. Definitions and classification. Primary graft dysfunction is reported as dysfunction ...
PubMed journal article Primary graft dysfunction and long-term pulmonary function after lung transplantatio were found in PRIME ... "Primary Graft Dysfunction and Long-term Pulmonary Function After Lung Transplantation." The Journal of Heart and Lung ... Primary Graft Dysfunction and Long-term Pulmonary Function After Lung Transplantation. J Heart Lung Transplant. 2007;26(10): ... Primary graft dysfunction and long-term pulmonary function after lung transplantation. J Heart Lung Transplant. 2007;26(10): ...
Primary graft dysfunction (PGD) is the most common cause of early morbidity and mortality following lung transplant and is ... AIM 3: The presence of primary graft dysfunction at 24 hours determined by CXR and Pa02/FiO2 ratio by reviewers blinded to ... AIM 3: The presence of any primary graft dysfunction determined by CXR and PaO2/FiO2 ratio (24, 48 or 72 hours) evaluated by ... Measurement of Extravascular Lung Water to Detect and Predict Primary Graft Dysfunction Following Lung Transplant. This study ...
PubMed journal article Collagen type-V is a danger signal associated with primary graft dysfunction in lung transplantatio were ... and primary graft dysfunction in lung transplantation.. *Lung-Restricted Antibodies Mediate Primary Graft Dysfunction and ... Primary graft dysfunction (PGD) is the leading cause of early mortality after lung transplantation. Anti-collagen type-V (col(V ... Collagen type-V Is a Danger Signal Associated With Primary Graft Dysfunction in Lung Transplantation. Transpl Immunol. 2019;56: ...
Diastolic Dysfunction Increases the Risk of Primary Graft Dysfunction after Lung Transplant. Am J Respir Crit Care Med. 2016; ... Primary graft dysfunction. Semin Respir Crit Care Med. 2013;34(3):305-319.. View this article via: PubMed CrossRef Google ... Risk factors for primary graft dysfunction after lung transplantation. J Thorac Cardiovasc Surg. 2006;131(1):73-80.. View this ... Primary graft dysfunction: lessons learned about the first 72 h after lung transplantation. Curr Opin Organ Transplant. 2015;20 ...
... ... Primary graft dysfunction (PGD) occurs in 10-25% of cases and remains responsible for significant morbidity and mortality after ... Ischaemic time of the last implanted graft and the lactate level at the end of the procedure are the only factors related to ... Our goal was to explore donor and recipient variables and procedure factors that could be related to early graft failure in ...
... higher plasma P-selectin levels reflecting platelet activation would therefore be associated with primary graft dysfunction ( ... Soluble P-Selectin and the Risk of Primary Graft Dysfunction After Lung Transplantation. Kawut, Steven M.; Okun, Jeffrey; ... higher plasma P-selectin levels reflecting platelet activation would therefore be associated with primary graft dysfunction ( ...
Prevention of primary graft dysfunction in lung transplantation by N-acetylcysteine after prolonged cold ischemia ... This study assessed the protective effect of NAC on primary graft dysfunction after lung transplantation.. METHODS: Porcine ... This study assessed the protective effect of NAC on primary graft dysfunction after lung transplantation.. METHODS: Porcine ... CONCLUSION: In this model, donor and recipient treatment with NAC effectively protected the lung from primary graft dysfunction ...
Primary graft dysfunction can be distinguished by a profile of differentially reactive autoantibodies binding to 17 proteins. ... Primary graft dysfunction can be distinguished by a profile of differentially reactive autoantibodies binding to 17 proteins. ... Primary graft dysfunction can be distinguished by a profile of differentially reactive autoantibodies binding to 17 proteins. ... Known as primary graft dysfunction (PGD), this condition increases mortality significantly. Complex interactions between donor ...
... On-line free medical diagnosis assistant. Ranked list of possible diseases from either several ... "primary graft dysfunction"Drugs, active principles and "primary graft dysfunction"Medicinal plantsQuestions and answers from ... Primary graft dysfunction. A form of ischemia-reperfusion injury occurring in the early period following transplantation. ... It is most often seen in the transplanted lung, liver, or kidney and can lead to graft rejection. ...
Report of the ISHLT Working Group on Primary Lung Graft Dysfunction part IV: Recipient-related risk factors and markers. ... Fingerprint Dive into the research topics of Report of the ISHLT Working Group on Primary Lung Graft Dysfunction part IV: ... Report of the ISHLT Working Group on Primary Lung Graft Dysfunction part IV : Recipient-related risk factors and markers. / ... Report of the ISHLT Working Group on Primary Lung Graft Dysfunction part IV: Recipient-related risk factors and markers. ...
Primary graft dysfunction (PGD), as characterized by pulmonary infiltrates and high oxygen requirements shortly after ... From: Mast cells in a murine lung ischemia-reperfusion model of primary graft dysfunction ...
Pathophysiology and classification of primary graft dysfunction after lung transplantation ... Diastolic Dysfunction Increases the Risk of Primary Graft Dysfunction after Lung Transplant. Am J Respir Crit Care Med 2016;193 ... Incidence and severity of primary graft dysfunction after lung transplantation using rejected grafts reconditioned with ex vivo ... Definition of primary graft dysfunction (PGD). PGD is a syndrome that encompasses a spectrum of mild to severe lung injury that ...
Primary Graft Dysfunction Post Heart Transplantation: Is There Greater Risk for De Novo Donor-Specific Antibody Development? ... Primary Graft Dysfunction After Pediatric Heart Transplant.. K. Mowers, K. Simpson, P. Eghtesady, O. Petrucci, C. Canter, C. ... Background: Primary graft dysfunction (PGD), as defined by ISHLT Consensus Guidelines, has been associated with worse outcomes ... CITATION INFORMATION: Mowers K, Simpson K, Eghtesady P, Petrucci O, Canter C, Castleberry C. Primary Graft Dysfunction After ...
... termed Primary Graft Dysfunction (PGD), is a major cause of early post-transplant morbidity and morta... ... Innate Immune Regulation of Primary Graft Dysfunction Huang, Howard J. Washington University, Saint Louis, MO, United States ... PROJECT NARRATIVE Primary graft dysfunction is the major cause of early morbidity and mortality following lung transplantation ... We aim to identify potential pharmacologic targeting strategies for treating primary graft dysfunction and improving post-lung ...
Primary outcome was severity of primary graft dysfunction within the first 72 hours.. Results. Primary graft dysfunction grade ... Primary graft dysfunction, a severe form of lung injury that occurs in the first 72 hours after lung transplant, is associated ... Implementation of a management guideline aimed at minimizing the severity of primary graft dysfunction after lung transplant. ... Implementation of a management guideline aimed at minimizing the severity of primary graft dysfunction after lung transplant ...
N2 - Primary graft dysfunction (PGD), a form of acute lung injury occurring within 72 h following lung transplantation, is ... AB - Primary graft dysfunction (PGD), a form of acute lung injury occurring within 72 h following lung transplantation, is ... Primary graft dysfunction (PGD), a form of acute lung injury occurring within 72 h following lung transplantation, is ... abstract = "Primary graft dysfunction (PGD), a form of acute lung injury occurring within 72 h following lung transplantation, ...
Primary graft dysfunction The most frequent cause of death in the first 30 days after transplant is when the new donor heart ... This is called primary graft dysfunction. Factors such as shock or trauma to the donor heart or narrowed blood vessels in the ... recipients lungs can cause primary graft dysfunction. Medicines (for example, inhaled nitric oxide and intravenous nitrates) ...
Early hemodynamic injury during donor brain death determines the severity of primary graft dysfunction after lung ...
A Novel Mechanism of Primary Graft Dysfunction and a New Therapeutic Target. Annals of the American Thoracic Society, 14(3), ... A Novel Mechanism of Primary Graft Dysfunction and a New Therapeutic Target, Annals of the American Thoracic Society, vol. 14 ... A Novel Mechanism of Primary Graft Dysfunction and a New Therapeutic Target. Annals of the American Thoracic Society. 2017 Sep ... A Novel Mechanism of Primary Graft Dysfunction and a New Therapeutic Target. In: Annals of the American Thoracic Society. 2017 ...
Nonclassical monocytes prompt primary graft dysfunction. Despite concerted efforts, primary graft dysfunction is a major cause ... ISHLT Working Group on Primary Lung Graft Dysfunction, Report of the ISHLT Working Group on Primary Lung Graft Dysfunction part ... Primary graft dysfunction is the predominant driver of mortality and graft loss after lung transplantation. Recruitment of ... Immunological link between primary graft dysfunction and chronic lung allograft rejection. Ann. Thorac. Surg. 86, 189-195 (2008 ...
Pentraxin 3 in primary graft dysfunction: the long and short of it. Zhang Y, McDyer JF. Zhang Y, et al. Am J Respir Crit Care ... Variation in PTX3 is associated with primary graft dysfunction after lung transplantation Joshua M Diamond 1 , Nuala J Meyer, ... Variation in PTX3 is associated with primary graft dysfunction after lung transplantation Joshua M Diamond et al. Am J Respir ... Obesity and primary graft dysfunction after lung transplantation: the Lung Transplant Outcomes Group Obesity Study. Lederer DJ ...
Interleukin-17 receptor polymorphism predisposes to primary graft dysfunction after lung transplantation Jana Somers 1 , David ... Interleukin-17 receptor polymorphism predisposes to primary graft dysfunction after lung transplantation Jana Somers et al. J ... Background: Primary graft dysfunction (PGD), with an incidence of 11% to 57%, is a major cause of morbidity and mortality ... Variation in PTX3 is associated with primary graft dysfunction after lung transplantation. Diamond JM, Meyer NJ, Feng R, ...
The term primary graft dysfunction (PGD) incorporates a continuum of disease severity from moderate to severe acute lung injury ... Pathophysiology and classification of primary graft dysfunction after lung transplantation. Lookup NU author(s): Dr Morvern ...
Lung Innate Lymphoid Cell Composition is Altered in Primary Graft Dysfunction. Submitted by jec3011 on August 12, 2019 - 4:41pm ... RATIONALE: Primary graft dysfunction (PGD) is the leading cause of early morbidity and mortality after lung transplantation but ... Home > Publications > Lung Innate Lymphoid Cell Composition is Altered in Primary Graft Dysfunction. ...
Background Primary graft dysfunction (PGD) is a frequent complication after cardiac transplantation and remains one of the ... Clinical Factors Implicated in Primary Graft Dysfunction After Heart Transplantation: A Single-center Experience Academic ...
Hidden immune cells play key role in driving primary graft dysfunction Northwestern Medicine scientists have discovered that a ... play a key role in driving primary graft dysfunction (PGD), the leading cause of death after lung transplantation. ...
Primary graft dysfunction after heart transplantation: Outcomes and resource utilization. Mohammed Quader, Robert B Hawkins, J ... Risk of severe primary graft dysfunction in patients bridged to heart transplantation with continuous-flow left ventricular ... PREDICTA: A Model to Predict Primary Graft Dysfunction After Adult Heart Transplantation in the United Kingdom. Sanjeet Singh ... OBJECTIVES: To evaluate the value of cardiac power output index (CPOi) in predicting severe primary graft dysfunction (PGD) ...
Aprotinin in lung transplantation is associated with an increased incidence of primary graft dysfunction. European Journal of ... Aprotinin in lung transplantation is associated with an increased incidence of primary graft dysfunction. In: European Journal ... Aprotinin in lung transplantation is associated with an increased incidence of primary graft dysfunction. / Marasco, Silvana F ... A recent study found a significant reduction in severe (grade III) primary graft dysfunction (PGD) in lung transplantation ...
Primary graft dysfunction after living donor liver transplantation is characterized by delayed functional hyperbilirubinemia. ... abstract = "The purpose of this study is to propose a new concept of primary graft dysfunction (PGD) after living donor liver ... N2 - The purpose of this study is to propose a new concept of primary graft dysfunction (PGD) after living donor liver ... AB - The purpose of this study is to propose a new concept of primary graft dysfunction (PGD) after living donor liver ...
  • Graft dysfunction describes different grades of graft ischemia-reperfusion injury and can manifest as early allograft dysfunction or primary graft non-function, its most severe form. (bvsalud.org)
  • 2) The term BOS should be retained to denote allograft dysfunction with delayed onset and persistent decline in FEV 1 (which is usually accompanied by evidence of airflow obstruction) that is not caused by other causes (some of which may be potentially reversible) of post-transplant loss of function. (ersjournals.com)
  • Physiology of chronic lung allograft dysfunction: back to the future? (ersjournals.com)
  • Chronic lung allograft dysfunction (CLAD) is, in one sense, a term without a true consensus definition, although its common usage in the field of lung transplantation implies a base understanding throughout the community that it describes a lung allograft that does not work (well) [ 1 ]. (ersjournals.com)
  • The topic of chronic lung allograft dysfunction, although important, was outside the scope of this workshop. (nih.gov)
  • Donor nonclassical monocytes mediate primary lung allograft dysfunction by recruiting neutrophils via MyD88-dependent production of CXCL2. (sciencemag.org)
  • A new index predicts early allograft dysfunction following living donor liver transplantation: A propensity score analysis. (semanticscholar.org)
  • Long-term survival after lung transplantation remains limited by the development of chronic lung allograft dysfunction (CLAD), which affects approximately 50% of lung recipients by 5 years post-transplant.1 Given the lack of a proven therapy once CLAD is diagnosed, risk factor mitigation is a key preventive strategy. (medworm.com)
  • ABSTRACT Primary graft dysfunction is a multifactorial syndrome with great impact on liver transplantation outcomes. (bvsalud.org)
  • A syngeneic rat (LEW [Lewis abstract]) orthotopic lung Tx model was used, grafts exposed to 18 hr cold ischemia before Tx. (uantwerpen.be)
  • Kulkarni H, Elvington M, Ma L, Cano M, Pugh K, Hachem R, Atkinson J, Gelman A. Alteration in Local Complement Activation in First 24h Post-Lung Transplantation (LTx) Helps Identify Recipients Developing Primary Graft Dysfunction [abstract]. (atcmeetingabstracts.com)
  • Primary graft dysfunction is the main cause of early mortality after heart transplantation (HT). (intechopen.com)
  • Despite surgical advances and improved long-term survival, heart transplant patients are still at significant risk to develop early graft dysfunction (EGD), leading to significant perioperative morbidity and mortality [ 2 , 4 , 5 ]. (intechopen.com)
  • Primary graft dysfunction (PGD) occurs in 10-25% of cases and remains responsible for significant morbidity and mortality after lung transplantation. (ovid.com)
  • Known as primary graft dysfunction (PGD), this condition increases mortality significantly. (dtu.dk)
  • Acute lung injury within 72 hours of lung transplantation, termed Primary Graft Dysfunction (PGD), is a major cause of early post-transplant morbidity and mortality. (grantome.com)
  • PROJECT NARRATIVE Primary graft dysfunction is the major cause of early morbidity and mortality following lung transplantation, and has been associated with an increased risk for developing bronchiolitis obliterans syndrome and late graft failure. (grantome.com)
  • Primary graft dysfunction, a severe form of lung injury that occurs in the first 72 hours after lung transplant, is associated with morbidity and mortality. (edu.au)
  • Primary graft dysfunction is the predominant driver of mortality and graft loss after lung transplantation. (sciencemag.org)
  • Primary graft dysfunction (PGD), with an incidence of 11% to 57%, is a major cause of morbidity and mortality within the first 30 days after lung transplantation (LTx). (cdc.gov)
  • The main outcome variables analysed were development of primary graft dysfunction, renal impairment and mortality. (elsevier.com)
  • The purpose of this study is to propose a new concept of primary graft dysfunction (PGD) after living donor liver transplantation (LDLT), characterized by delayed functional hyperbilirubinemia (DFH) and a high early graft mortality rate. (elsevier.com)
  • PGD after LDLT is associated with DFH-20 caused by graft, recipient and surgical factors, and increases the risk of early graft mortality. (elsevier.com)
  • Primary graft dysfunction (PGD), as characterized by pulmonary infiltrates and high oxygen requirements shortly after reperfusion, is the major cause of early morbidity and mortality after lung transplantation. (biomedcentral.com)
  • Primary graft dysfunction (PGD) and obliterative bronchiolitis (OB) are the leading causes of early and late mortality, respectively. (elsevier.com)
  • We hypothesized that preoperative plasma B-type natriuretic peptide would independently predict in-hospital postoperative ventricular dysfunction, hospital stay, and up to 5-year mortality after primary coronary artery bypass grafting. (elsevier.com)
  • Multivariable analyses assessed independent roles of preoperative B-type natriuretic peptide in predicting postoperative ventricular dysfunction, hospital stay, and 5-year all-cause mortality. (elsevier.com)
  • Results: Preoperative plasma B-type natriuretic peptide concentration predicted ventricular dysfunction, hospital stay, and mortality in univariate and multivariable analyses. (elsevier.com)
  • Conclusion: Preoperative plasma B-type natriuretic peptide independently predicted in-hospital ventricular dysfunction, hospital stay, and up to 5-year all-cause mortality after primary coronary artery bypass grafting. (elsevier.com)
  • The univariate and multivariate analyses revealed no association between maEDC grafts and one-year patient mortality. (nih.gov)
  • AbstractPrimary graft dysfunction (PGD) remains the leading cause of early mortality post-heart transplantation. (medworm.com)
  • Adult survivors of childhood cancer are at considerable risk of long-term morbidity and mortality beyond the recurrence of their primary malignancy. (aafp.org)
  • Children with pulmonary vascular resistance indices greater than 6 Wood units/m 2 are more susceptible to the development of right ventricular dysfunction and mortality. (scielo.br)
  • ischemic times greater than three to four hours are associated with high mortality in the first 30 days because of primary graft failure ( 11 - 13 ). (scielo.br)
  • Hyperlactataemia most probably reflects the severity of early PGD, which leaves graft ischaemic time as the only factor predicting early PGD in a multicentre population of cystic fibrosis lung graft recipients. (ovid.com)
  • Primary graft dysfunction (PGD), as defined by ISHLT Consensus Guidelines, has been associated with worse outcomes in adult heart transplant recipients, even in patients who do not require mechanical support. (atcmeetingabstracts.com)
  • Daud and colleagues found that among 334 lung-transplant recipients, 130 (39%) had grade 1 primary graft dysfunction, 69 (20%) had grade 2, and 70 (21%) had grade 3. (medscape.com)
  • Central Venous Pressure Monitoring in Living Donor Kidney Recipients does not affect Immediate Graft Function: a propensity score analysis. (bioportfolio.com)
  • The researchers found that lung transplant recipients who were given lungs from smokers had a 5 percent higher risk of developing primary graft dysfunction than those who received lungs from nonsmokers. (allergyasthmatech.com)
  • Compared to normal-weight lung-transplant recipients, the risk of primary graft dysfunction was 7 percent higher in overweight recipients and 11 percent higher in obese recipients. (allergyasthmatech.com)
  • Diamond and his colleagues found that recipients with primary graft dysfunction had a 23 percent risk of dying within 90 days of their transplant, compared with a 5 percent risk for those without the complication. (allergyasthmatech.com)
  • The incidence of graft failure at 1 year is 9.8% for recipients of deceased donor livers. (medscape.com)
  • One-year graft survival was higher in recipients of no-maEDC grafts. (nih.gov)
  • Graft survival differed between the recipients of no-maEDC and maEDC organs after correcting for a laboratory model of end-stage liver disease (labMELD) score with a cut-off value of 20, but patient survival did not. (nih.gov)
  • Patient survival did not differ between recipients who did and did not meet the Milan criteria and who received grafts with and without maEDC. (nih.gov)
  • Rationale Primary graft dysfunction in lung transplant recipients derives from the initial, largely leukocyte-dependent, ischaemia-reperfusion injury. (bmj.com)
  • In this article we aim to familiarize primary care practitioners with some of the basics of allogeneic and autologous transplantation, as well as issues relevant to the care of transplant recipients over the short and the long term. (cmaj.ca)
  • Severe primary graft dysfunction (PGD) is associated with poor early outcomes after lung transplantation (LTx). (unboundmedicine.com)
  • Possible deleterious effects on primary graft function have been documented, but do not appear to significantly impair short- and long-term outcomes. (elsevier.com)
  • We aim to identify potential pharmacologic targeting strategies for treating primary graft dysfunction and improving post-lung transplant outcomes. (grantome.com)
  • Graft dysfunction immediately after reperfusion predicts short-term outcomes in living-donor lobar lung transplantation but not in cadaveric lung transplantation. (qxmd.com)
  • Lung Transplant Outcomes Group (LTOG) 2018, ' Cell-free hemoglobin promotes primary graft dysfunction through oxidative lung endothelial injury ', JCI Insight , vol. 3, no. 2. (elsevier.com)
  • Unexpected donor pulmonary embolism affects early outcomes after lung transplantation: a major mechanism of primary graft failure? (springer.com)
  • Delayed graft function (DGF) is a common complication following kidney transplantation adversely affecting graft outcomes. (bioportfolio.com)
  • Efforts to better understand, predict and prevent primary graft dysfunction would dramatically improve outcomes for lung-transplant patients, the researchers said. (allergyasthmatech.com)
  • this study presents the outcomes of dorsal and ventral buccal graft urethroplasty at a sub-Saharan tertiary hospital. (hindawi.com)
  • There was no difference between dorsal and ventral onlay buccal graft outcomes for bulbar urethral strictures. (hindawi.com)
  • 14 h) influence graft and patient outcomes after liver transplantation. (nih.gov)
  • Preventive strategies to avoid primary graft dysfunction (PGD) have been focused on better donor choice and maintenance, heart preservation methods in long-distance retrievals with prolonged ischemia time, and better myocardial protection during implantation, among others. (intechopen.com)
  • Our goal was to explore donor and recipient variables and procedure factors that could be related to early graft failure in cystic fibrosis patients receiving bilateral lung transplantation, the PGD grade being derived from the PaO2/FiO2 ratio measured at the sixth post-operative hour. (ovid.com)
  • CONCLUSION: In this model, donor and recipient treatment with NAC effectively protected the lung from primary graft dysfunction after prolonged cold ischemia. (uzh.ch)
  • Factors such as shock or trauma to the donor heart or narrowed blood vessels in the recipient's lungs can cause primary graft dysfunction. (health24.com)
  • These intravascular cells were donor-derived and were also detectable in human lung grafts being used for transplant. (sciencemag.org)
  • Warm retrograde perfusion can remove more fat from lung grafts with fat embolism in a porcine donor model. (springer.com)
  • Retrograde flush following warm ischemia in the non-heart-beating donor results in superior graft performance at reperfusion. (springer.com)
  • To identify factors predictive of early graft loss in the first 3 months after living donor liver transplantation. (scielo.br)
  • Seventy-eight adults submitted to living donor liver transplantation were divided into group I with 62 (79.5%) patients with graft survival longer than 3 months, and group II with 16 (20.5%) patients who died and/or showed graft failure within 3 months after liver transplantation. (scielo.br)
  • 0.8 ratios are associated with higher probability of graft failure after living donor liver transplantation. (scielo.br)
  • It is required to establish an adequate definition of delayed graft function in deceased donor kidney transplantation. (bioportfolio.com)
  • Delayed graft function (DGF) is a major complication following deceased donor renal transplantation. (bioportfolio.com)
  • Delayed graft function (DGF) is a common complication after kidney transplantation in the era of accepting an equal number of brain- and circulatory-death donor kidneys in the Netherlands. (bioportfolio.com)
  • The researchers also concluded that some previously identified risk factors -- including donor sex, race, age and cause of death -- were not associated with primary graft dysfunction. (allergyasthmatech.com)
  • The workshop included presentations in the areas of recipient selection, donor management, perioperative issues, and primary grant dysfunction, as well as discussion of the research gaps and priorities for lung transplantation research. (nih.gov)
  • Develop novel therapies based on donor and/or recipient endotypes to prevent primary graft dysfunction. (nih.gov)
  • Objective To define the role of donor intravascular monocytes in lung transplant-related acute lung injury and primary graft dysfunction. (bmj.com)
  • In human lungs, correlations were observed between pre-implantation donor monocyte numbers/their CD86 and TREM-1 expression and post-implantation lung dysfunction at 48 and 72 hours. (bmj.com)
  • Retention and activation of intravascular monocytes in perfused murine and human donor lungs suggests an important and previously unrecognised role as passenger leukocytes contributing to lung injury and primary graft dysfunction, emphasising their potential as therapeutic targets in lung transplantation. (bmj.com)
  • Racial Disparities in Kidney Graft Survival: Does Donor Quality Explain the Difference? (ingentaconnect.com)
  • Primary graft dysfunction and long-term pulmonary function after lung transplantation. (unboundmedicine.com)
  • Collagen type-V is a danger signal associated with primary graft dysfunction in lung transplantation. (unboundmedicine.com)
  • We hypothesized that higher plasma P-selectin levels reflecting platelet activation would therefore be associated with primary graft dysfunction (PGD) after lung transplantation. (columbia.edu)
  • This study assessed the protective effect of NAC on primary graft dysfunction after lung transplantation. (uzh.ch)
  • The term primary graft dysfunction (PGD) incorporates a continuum of disease severity from moderate to severe acute lung injury (ALI) within 72 h of lung transplantation. (amegroups.com)
  • Primary graft dysfunction (PGD), a form of acute lung injury occurring within 72 h following lung transplantation, is characterized by pulmonary edema and diffuse alveolar damage. (elsevier.com)
  • Christie, J. D. / Plasma intercellular adhesion molecule-1 and von Willebrand factor in primary graft dysfunction after lung transplantation . (elsevier.com)
  • The primary outcome was International Society for Heart and Lung Transplantation grade 3 PGD at 48 or 72 hours post-transplant. (northwestern.edu)
  • Christie, Jason D. / Clinical risk factors for primary graft dysfunction after lung transplantation . (northwestern.edu)
  • Despite concerted efforts, primary graft dysfunction is a major cause of graft failure after organ transplantation. (sciencemag.org)
  • In lung transplantation, primary graft dysfunction is known to be mediated by early neutrophil infiltration. (sciencemag.org)
  • Elevated long pentraxin-3 (PTX3) levels are associated with the development of primary graft dysfunction (PGD) after lung transplantation. (cdc.gov)
  • Northwestern Medicine scientists have discovered that a subset of immune cells called nonclassical monocytes (NCMs), previously unknown to reside in the lungs, play a key role in driving primary graft dysfunction (PGD), the leading cause of death after lung transplantation. (news-medical.net)
  • Risk of severe primary graft dysfunction in patients bridged to heart transplantation with continuous-flow left ventricular assist devices. (qxmd.com)
  • PREDICTA: A Model to Predict Primary Graft Dysfunction After Adult Heart Transplantation in the United Kingdom. (qxmd.com)
  • Prognostic Value of High-Sensitivity Troponin-T to Identify Patients at Risk of Left Ventricular Graft Dysfunction After Heart Transplantation. (qxmd.com)
  • Validation of the proposed International Society for Heart and Lung Transplantation grading system for primary graft dysfunction after lung transplantation. (qxmd.com)
  • Report from a consensus conference on primary graft dysfunction after cardiac transplantation. (qxmd.com)
  • A recent study found a significant reduction in severe (grade III) primary graft dysfunction (PGD) in lung transplantation where aprotinin had been used. (elsevier.com)
  • Primary graft dysfunction (PGD) is acute lung injury within 72 hours of lung transplantation. (elsevier.com)
  • In lung transplantation, unexpected pulmonary emboli, including thrombi and fat, have been observed with high probability and are associated with potential primary graft dysfunction. (springer.com)
  • ObjectiveTo evaluate the prevention and treatment of primary graft dysfunction ( PGD ) after lung transplantation (LTx).MethodsWe retrospectively analyzed clinical data of108 cases of lung transplantation from September 2002 to June 2011. (bvsalud.org)
  • The objective of this study is to evaluate the safety and efficacy of conversion from tacrolimus to sirolimus early after kidney transplantation in patients with delayed graft function (DG. (bioportfolio.com)
  • Predicition models for delayed graft function: external validation on The Dutch Prospective Renal Transplantation Registry. (bioportfolio.com)
  • This study focused on the value of quantitatively analyzed and qualitatively graded renal scintigraphy in relation to the expected duration of delayed graft function after kidney transplantation. (bioportfolio.com)
  • During kidney transplantation, intraoperative fluid management can affect post-transplant graft function. (bioportfolio.com)
  • General dysfunction of an organ occurring immediately following its transplantation. (bioportfolio.com)
  • The term most frequently refers to renal dysfunction following KIDNEY TRANSPLANTATION. (bioportfolio.com)
  • Lung injury from I/R, termed primary graft dysfunction, is a major complication after lung transplantation and is considered as a major factor for transplant failure ( 27 , 36 , 64 , 65 , 102 ). (physiology.org)
  • Primary graft dysfunction is the major cause of serious illness and death after lung transplantation. (allergyasthmatech.com)
  • Serious primary graft dysfunction usually occurs within three days after lung transplantation. (allergyasthmatech.com)
  • Lung size mismatch and primary graft dysfunction after bilateral lung transplantation. (hopkinsmedicine.org)
  • The success of orthotopic liver transplantation (OLT) in treatment of liver malignancy and endstage liver disease has led to an increase in the gap between patients on waiting-lists and available liver grafts. (centerwatch.com)
  • Non-IPF interstitial lung diseases (8%), lung re-transplantation after graft failure (4%) and alpha-1 antitrypsin deficiency-associated emphysema (2%) are the other major indications, while a variety of other disorders of the lung parenchyma, airways, and vasculature each account for a small percentage of transplants annually. (oncologynurseadvisor.com)
  • Primary graft dysfunction can result in transplantation failure. (sciencemag.org)
  • A single nucleotide polymorphism of Toll-like receptor 4 identifies the risk of developing graft failure after liver transplantation. (semanticscholar.org)
  • Resident lung mononuclear phagocytes have been implicated in ischaemia-reperfusion injury and the development of primary graft dysfunction following lung transplantation, but the contribution of lung intravascular monocytes to lung transplant-related injury is not known. (bmj.com)
  • A major source of graft failure and dysfunction in lung transplantation is known to be bronchiolitis obliterans (BO)and its clinical correlate called bronchiolitis obliterans syndrome(BOS). (bioportfolio.com)
  • This review is intended as a basic overview of allogeneic and autologous stem cell transplantation with a special focus on long-term follow-up issues relevant to primary care providers. (cmaj.ca)
  • After transplantation, none of the patients needed extracorporeal mechanical oxygenation (ECMO) due to primary graft dysfunction. (medpagetoday.com)
  • In 2014 The International Society Of Heart and Lung Transplantation consensus report was published to provide guidelines on the prevention, diagnosis and treatment of primary graft dysfunction (PGD) following cardiac transplantation 3 . (businesswire.com)
  • The study's aim was to determine whether development of severe primary graft dysfunction in the perioperative period was associated with reduced long term rates of survival or with diminished long term pulmonary function. (unboundmedicine.com)
  • The study authors evaluated risk factors for severe primary graft dysfunction, a complication that affects up to 25 percent of lung-transplant patients shortly after surgery. (allergyasthmatech.com)
  • Severe dysfunction of another major organ or organ system (including severe uncorrected atherosclerotic disease and severe skeletal abnormalities of chest wall). (oncologynurseadvisor.com)
  • In hyperacute and acute liver failure the clinical picture develops rapidly with progressive encephalopathy and multiorgan dysfunction such as hyperdynamic circulation, coagulopathy, acute kidney injury and respiratory insufficiency, severe metabolic alterations and cerebral edema that can lead to brain death. (wikipedia.org)
  • Because depletion of nonclassical monocytes prevented primary graft dysfunction in the mouse models, targeting this cell population during human transplant could lead to improved rates of graft success. (sciencemag.org)
  • Using a novel mouse orthotopic lung transplant model that replicates the physiologic, histopathologic and immunologic features of human PGD, we will test this hypothesis with two specific aims: 1) Characterize the role of toll-like receptors 2 and 4 in ischemia-reperfusion-induced lung graft injury, and 2) Characterize the role of damage-associated molecular patterns in ischemia-reperfusion-induced lung graft injury. (grantome.com)
  • Primary graft dysfunction (PGD) is a form of acute lung injury driven by ischemia-reperfusion mediated damage. (atcmeetingabstracts.com)
  • The purpose of this study is to investigate local activation of the coagulation system in the kidney graft during organ preservation and during early reperfusion in adult kidney transplant. (bioportfolio.com)
  • Hyperacute rejection (due to blood type incompatibility) is extremely rare, but when manifest, results in profound graft failure shortly after reperfusion. (renalandurologynews.com)
  • Graft survival. (scielo.br)
  • Maintenance of vascularity in the graft promotes its viability, function, and survival in the recipient. (bioportfolio.com)
  • Instead of being discarded, maEDC grafts may expand the organ pool for patients with HCC without impairing patient survival or recurrence-free survival. (nih.gov)
  • 31 patients presented partial or complete remission, and glomerulopathy appeared not to impact graft and patient survival. (hindawi.com)
  • A postoperative transpulmonary gradient greater than 15 mmHg, associated with low cardiac output, was considered as graft dysfunction secondary to pulmonary hypertension classified as SGD. (intechopen.com)
  • A comparison of continuous intravenous epoprostenol (prostacyclin) with conventional therapy for primary pulmonary hypertension. (medscape.com)
  • The Primary Pulmonary Hypertension Study Group. (medscape.com)
  • Primary pulmonary hypertension? (springer.com)
  • During the immediate postoperative period, the main complications are primary graft failure, right ventricular failure, pulmonary hypertension crisis, rejection and infection. (scielo.br)
  • This week's articles describe how broccoli can combat type 2 diabetes, how monocytes contribute to the failure of organ transplant grafts, and how to more durably treat RET- or KRAS-driven lung cancer. (sciencemag.org)
  • found that inhibiting chemokine secretion from a population of monocytes may improve graft success in patients receiving organ transplants. (sciencemag.org)
  • They found that nonclassical monocytes recruited destructive neutrophils, known mediators of primary graft dysfunction. (sciencemag.org)
  • Importantly, PGD is also a risk factor for developing Bronchiolitis Obliterans Syndrome, the main cause of late graft failure and death in this population. (grantome.com)
  • Logistic regression demonstrated preoperative B-type natriuretic peptide to independently predict ventricular dysfunction (odds ratio 1.92, 95% confidence interval 1.12-3.29, P = .018), after adjustment for preoperative left ventricular ejection fraction, congestive heart failure severity, and other clinical predictors. (elsevier.com)
  • Focus Theme: Early Graft Failure. (medscape.com)
  • ONLINE COVER Stowaway Cells Foster Graft Failure. (sciencemag.org)
  • All 12 patients who got lungs preserved with the novel system survived the transplant without graft failure at 30 days, Gregor Warnecke, MD, of Hanover Medical School in Hanover, Germany, and colleagues found. (medpagetoday.com)
  • Primary graft dysfunction (PGD) is a form of acute lung injury resulting in non-cardiogenic pulmonary edema and often significant difficulty in maintaining adequate oxygenation. (renalandurologynews.com)
  • 24 hours following lung transplant, the investigators will evaluate whether the combination of extravascular lung water and pulmonary permeability measurements at 24 hours correlate with the presence and severity of primary graft dysfunction (PGD) at 24 hours. (clinicaltrials.gov)
  • Primary outcome was severity of primary graft dysfunction within the first 72 hours. (edu.au)
  • Implementation of an evidence-based guideline for managing respiratory and hemodynamic status is feasible and safe and was associated with reduction in severity of primary graft dysfunction. (edu.au)
  • Further studies are required to determine whether such a guideline would lead to a consistent reduction in severity of primary graft dysfunction at other institutions. (edu.au)
  • The purpose of this trial is to evaluate the reduction in incidence and severity of delayed graft function with kidney allografts from donors >45 years after brain death (DBD). (bioportfolio.com)
  • Inadequate perioperative prophylaxis and postsurgical complications after graft implantation are important risk factors for subsequent vascular graft infections - prospective results from the VASGRA Cohort Study. (uzh.ch)
  • Here, we investigated the effect of intragraft CD26/DPP IV catalytic inhibition on primary graft dysfunction during 7 day post-Tx, following extended ischemia. (uantwerpen.be)
  • Primary graft dysfunction has now been established as a well-defined syndrome occurring during the initial post-transplant phase and is an important risk factor for the development of bronchiolitis obliterans. (medscape.com)
  • In the allogeneic setting, graft-versus-host disease may also develop, making post-transplant management complex. (cmaj.ca)
  • Recent studies suggest that acetaminophen (APAP), a specific hemoprotein reductant, can abrogate CFH-mediated oxidative injury and organ dysfunction. (elsevier.com)
  • The presence of significant extrapulmonary vital organ dysfunction can sometimes be addressed with multi-organ transplants (e.g., heart-lung, liver-lung) in select candidates. (oncologynurseadvisor.com)
  • However, the high-dose conditioning regimen can lead to major organ dysfunction, life-threatening infection and bleeding. (cmaj.ca)
  • Late adverse effects can impair organ function, stunt growth and development, and cause neurocognitive dysfunction and secondary malignancies. (aafp.org)
  • Although there is no strong evidence to support the elective use of cardiopulmonary bypass in the absence of hemodynamic or intra-operative factors, its use should not be deferred secondary to fear of graft dysfunction. (elsevier.com)
  • Beyond the issue of PGD, other concerns, such as bleeding with increased need of blood and/or blood products as well as overall resource utilization, may support the role of primary lung transplant without cardiopulmonary bypass. (elsevier.com)
  • Methods: This is a prospective, longitudinal study of 1023 patients at two institutions undergoing primary coronary artery bypass grafting with cardiopulmonary bypass. (elsevier.com)
  • Based on the current body of literature, recipient-related risk factors that would require further study before any association can be stated include the type of procedure, the presence of hepatic dysfunction, and pleural adhesions and/or prior surgery, which increase the risk of post-operative bleeding. (elsevier.com)
  • Presently, the strongest and most clearly established recipient risk factor for primary graft dysfunction is the diagnosis of PPH. (elsevier.com)
  • The variables analyzed were gender, age, etiology of liver disease, Child-Pugh classification, model of end-stage liver disease (MELD score), pretransplantation serum sodium level, and graft weight-to-recipient body weight (GRBW) ratio. (scielo.br)
  • Once a transplant recipient is discharged from hospital and returns to his or her local community, the primary care physician can play an important role in care. (cmaj.ca)
  • Wilkes, DS 2012, ' Autoantibody formation in human and rat studies of chronic rejection and primary graft dysfunction ', Seminars in Immunology , vol. 24, no. 2, pp. 131-135. (elsevier.com)
  • Extracorporeal life support (ECLS) should be installed early, before the occurrence of multiorgan dysfunction or prior to cardiac arrest, as highlighted in the literature. (intechopen.com)
  • Ventricular dysfunction was defined as requirement for at least two inotropes or new intra-aortic balloon pump or ventricular assist device support after coronary artery bypass grafting. (elsevier.com)
  • Primary graft dysfunction can be distinguished by a profile of differentially reactive autoantibodies binding to 17 proteins. (dtu.dk)
  • Primary graft dysfunction definition, diagnostic criteria and risk factors differ between studies. (bvsalud.org)
  • 18. The chi-square test, Student t -test and uni- and multivariate analysis were used for the evaluation of risk factors for early graft loss. (scielo.br)
  • The investigators will compare whether immediate (time 0) post operative measurements of the combination of extravascular lung water and pulmonary permeability can predict the later onset (24 hours) of primary graft dysfunction. (clinicaltrials.gov)
  • Can transplant renal scintigraphy predict the duration of delayed graft function? (bioportfolio.com)
  • This risk was independent of acute rejection and there was no association between primary graft dysfunction and acute rejection. (medscape.com)
  • Myelopoiesis is invariably present, and contributes to pathology, in animal models of graft versus host disease (GVHD). (jci.org)
  • 1 , 2 Since that time, despite uneven progress and problems with entities such as graft-versus-host disease (GVHD), 3 , 4 the procedure has become an accepted treatment for various hematologic deficiencies and malignant conditions. (cmaj.ca)
  • Lower postoperative fluid balances (P = .01) and vasopressor doses (P = .007) were seen, with no associated renal dysfunction. (edu.au)
  • Primary graft dysfunction grade was progressively lower in patients treated after introduction of the guideline (P = .01). (edu.au)
  • Seventy-two patients with bulbar urethral strictures underwent buccal graft one-stage urethroplasty. (hindawi.com)
  • Consecutive patients presenting with difficulty in passing urine (weak stream, incomplete emptying, and frequency) due to a penile urethra stricture were recruited in two phases: over a 12-month period for dorsal onlay grafting and the subsequent 12 months another set was recruited for ventral onlay grafting. (hindawi.com)
  • patients were asked if they were satisfied or not with the ease of voiding urine, erectile dysfunction (ED), and postvoid dribbing. (hindawi.com)
  • Only patients with histological diagnosis of MN in kidney grafts were included. (hindawi.com)
  • This article will review the late adverse effects of childhood cancer therapy and the transition of patients from pediatric oncologists to physicians in adulthood, and explain how primary care physicians can use these tools to provide appropriate care to adult survivors of childhood cancer. (aafp.org)
  • Human primary alveolar epithelial cells were exposed to in vitro stretch to explore the cellular source of extracellular Cyclophilin A, and Cyclophilin A levels were measured in bronchoalveolar lavage fluid from acute respiratory distress syndrome patients, to evaluate clinical relevance. (imperial.ac.uk)
  • His history is notable for five-vessel coronary artery bypass graft 8 years ago and endovascular repair of an abdominal aortic aneurysm 5 years ago. (springer.com)
  • There are two basic entities that compose of EGD: primary graft dysfunction (PGD) and secondary graft dysfunction (SGD). (intechopen.com)
  • Our primary end-point was PGD and secondary end-points were time to extubation, intensive care unit (ICU) stay, bronchoalveolar lavage neutrophilia and serum C-reactive protein. (cdc.gov)
  • In addition to providing regular medical care, primary care physicians of childhood cancer survivors need to perform surveillance for secondary cancers, identify late adverse effects of therapy, and attend to psychosocial needs. (aafp.org)
  • Proper use of these guidelines will allow primary care physicians to understand a patient's individual risk, provide additional screening as needed, and identify late adverse effects of childhood cancer early. (aafp.org)
  • During follow-up, Takotsubo cardiomyopathy was diagnosed, primary graft dysfunction related to cardiomyopathy was observed, and extracorporeal membrane oxygenation was required. (dergisi.org)