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PrilocaineAnesthetics, LocalMepivacaineLidocaineCarticaineAnesthesia, LocalAnesthesia, DentalFelypressinMaxillary NerveDental Pulp TestAnesthesia, ConductionAnesthetics, CombinedMouth RehabilitationMethemoglobinemiaAnesthesia, SpinalAmbulatory Surgical ProceduresTetracaineOintmentsNerve BlockToluidinesNordefrinBupivacainePhlebotomyLacerationsUrinationFemoral NervePseudocholinesteraseEncyclopedias as TopicSkin CreamPhysician-Patient RelationsPhytotherapyDrugs, Chinese HerbalUniversal PrecautionsEpinephrinePancreatinSurgical InstrumentsPeptic Ulcer HemorrhageVasoconstrictor AgentsGastrointestinal HemorrhageQuinazolinesPharmaceutical PreparationsInternational Classification of DiseasesHysterosalpingographyFallopian Tube Patency TestsCryingFallopian Tube DiseasesPharmaceutical Services, OnlineCounterfeit DrugsPharmaciesLegislation, PharmacyIce Cream
Prilocaine: A local anesthetic that is similar pharmacologically to LIDOCAINE. Currently, it is used most often for infiltration anesthesia in dentistry.Anesthetics, Local: Drugs that block nerve conduction when applied locally to nerve tissue in appropriate concentrations. They act on any part of the nervous system and on every type of nerve fiber. In contact with a nerve trunk, these anesthetics can cause both sensory and motor paralysis in the innervated area. Their action is completely reversible. (From Gilman AG, et. al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed) Nearly all local anesthetics act by reducing the tendency of voltage-dependent sodium channels to activate.Mepivacaine: A local anesthetic that is chemically related to BUPIVACAINE but pharmacologically related to LIDOCAINE. It is indicated for infiltration, nerve block, and epidural anesthesia. Mepivacaine is effective topically only in large doses and therefore should not be used by this route. (From AMA Drug Evaluations, 1994, p168)Lidocaine: A local anesthetic and cardiac depressant used as an antiarrhythmia agent. Its actions are more intense and its effects more prolonged than those of PROCAINE but its duration of action is shorter than that of BUPIVACAINE or PRILOCAINE.Carticaine: A thiophene-containing local anesthetic pharmacologically similar to MEPIVACAINE.Anesthesia, Local: A blocking of nerve conduction to a specific area by an injection of an anesthetic agent.Anesthesia, Dental: A range of methods used to reduce pain and anxiety during dental procedures.Felypressin: A synthetic analog of LYPRESSIN with a PHENYLALANINE substitution at residue 2. Felypressin is a vasoconstrictor with reduced antidiuretic activity.Maxillary Nerve: The intermediate sensory division of the trigeminal (5th cranial) nerve. The maxillary nerve carries general afferents from the intermediate region of the face including the lower eyelid, nose and upper lip, the maxillary teeth, and parts of the dura.Dental Pulp Test: Investigations conducted on the physical health of teeth involving use of a tool that transmits hot or cold electric currents on a tooth's surface that can determine problems with that tooth based on reactions to the currents.Anesthesia, Conduction: Injection of an anesthetic into the nerves to inhibit nerve transmission in a specific part of the body.Anesthetics, Combined: The use of two or more chemicals simultaneously or sequentially to induce anesthesia. The drugs need not be in the same dosage form.Mouth Rehabilitation: Process of restoring damaged or decayed teeth using various restorative and non-cosmetic materials so that oral health is improved.Methemoglobinemia: The presence of methemoglobin in the blood, resulting in cyanosis. A small amount of methemoglobin is present in the blood normally, but injury or toxic agents convert a larger proportion of hemoglobin into methemoglobin, which does not function reversibly as an oxygen carrier. Methemoglobinemia may be due to a defect in the enzyme NADH methemoglobin reductase (an autosomal recessive trait) or to an abnormality in hemoglobin M (an autosomal dominant trait). (Dorland, 27th ed)Anesthesia, Spinal: Procedure in which an anesthetic is injected directly into the spinal cord.Ambulatory Surgical Procedures: Surgery performed on an outpatient basis. It may be hospital-based or performed in an office or surgicenter.Tetracaine: A potent local anesthetic of the ester type used for surface and spinal anesthesia.Ointments: Semisolid preparations used topically for protective emollient effects or as a vehicle for local administration of medications. Ointment bases are various mixtures of fats, waxes, animal and plant oils and solid and liquid hydrocarbons.Nerve Block: Interruption of NEURAL CONDUCTION in peripheral nerves or nerve trunks by the injection of a local anesthetic agent (e.g., LIDOCAINE; PHENOL; BOTULINUM TOXINS) to manage or treat pain.ToluidinesNordefrin: A norepinephrine derivative used as a vasoconstrictor agent.Bupivacaine: A widely used local anesthetic agent.Phlebotomy: The techniques used to draw blood from a vein for diagnostic purposes or for treatment of certain blood disorders such as erythrocytosis, hemochromatosis, polycythemia vera, and porphyria cutanea tarda.Lacerations: Torn, ragged, mangled wounds.Urination: Discharge of URINE, liquid waste processed by the KIDNEY, from the body.Femoral Nerve: A nerve originating in the lumbar spinal cord (usually L2 to L4) and traveling through the lumbar plexus to provide motor innervation to extensors of the thigh and sensory innervation to parts of the thigh, lower leg, and foot, and to the hip and knee joints.Pseudocholinesterase: An aspect of cholinesterases.Encyclopedias as Topic: Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)Skin Cream: A water-soluble medicinal preparation applied to the skin.Physician-Patient Relations: The interactions between physician and patient.Phytotherapy: Use of plants or herbs to treat diseases or to alleviate pain.Drugs, Chinese Herbal: Chinese herbal or plant extracts which are used as drugs to treat diseases or promote general well-being. The concept does not include synthesized compounds manufactured in China.Universal Precautions: Prudent standard preventive measures to be taken by professional and other health personnel in contact with persons afflicted with a communicable disease, to avoid contracting the disease by contagion or infection. Precautions are especially applicable in the diagnosis and care of AIDS patients.Epinephrine: The active sympathomimetic hormone from the ADRENAL MEDULLA. It stimulates both the alpha- and beta- adrenergic systems, causes systemic VASOCONSTRICTION and gastrointestinal relaxation, stimulates the HEART, and dilates BRONCHI and cerebral vessels. It is used in ASTHMA and CARDIAC FAILURE and to delay absorption of local ANESTHETICS.Pancreatin: A mammalian pancreatic extract composed of enzymes with protease, amylase and lipase activities. It is used as a digestant in pancreatic malfunction.Surgical Instruments: Hand-held tools or implements used by health professionals for the performance of surgical tasks.Peptic Ulcer Hemorrhage: Bleeding from a PEPTIC ULCER that can be located in any segment of the GASTROINTESTINAL TRACT.Vasoconstrictor Agents: Drugs used to cause constriction of the blood vessels.Gastrointestinal Hemorrhage: Bleeding in any segment of the GASTROINTESTINAL TRACT from ESOPHAGUS to RECTUM.QuinazolinesPharmaceutical Preparations: Drugs intended for human or veterinary use, presented in their finished dosage form. Included here are materials used in the preparation and/or formulation of the finished dosage form.International Classification of Diseases: A system of categories to which morbid entries are assigned according to established criteria. Included is the entire range of conditions in a manageable number of categories, grouped to facilitate mortality reporting. It is produced by the World Health Organization (From ICD-10, p1). The Clinical Modifications, produced by the UNITED STATES DEPT. OF HEALTH AND HUMAN SERVICES, are larger extensions used for morbidity and general epidemiological purposes, primarily in the U.S.Hysterosalpingography: Radiography of the uterus and fallopian tubes after the injection of a contrast medium.Fallopian Tube Patency Tests: Methods for assessing the patency of the fallopian tubes.Crying: To utter an inarticulate, characteristic sound in order to communicate or express a feeling, or desire for attention.Fallopian Tube Diseases: Diseases involving the FALLOPIAN TUBES including neoplasms (FALLOPIAN TUBE NEOPLASMS); SALPINGITIS; tubo-ovarian abscess; and blockage.Pharmaceutical Services, Online: Pharmacy services accessed via electronic means.Counterfeit Drugs: Drugs manufactured and sold with the intent to misrepresent its origin, authenticity, chemical composition, and or efficacy. Counterfeit drugs may contain inappropriate quantities of ingredients not listed on the label or package. In order to further deceive the consumer, the packaging, container, or labeling, may be inaccurate, incorrect, or fake.Pharmacies: Facilities for the preparation and dispensing of drugs.Legislation, Pharmacy: Laws and regulations, pertaining to the field of pharmacy, proposed for enactment or enacted by a legislative body.Ice Cream: A frozen dairy food made from cream or butterfat, milk, sugar, and flavorings. Frozen custard and French-type ice creams also contain eggs.

Pharmacokinetics of prilocaine after intravenous administration in volunteers: enantioselectivity. (1/141)

BACKGROUND: Prilocaine exists in two stereoisomeric configurations, the enantiomers S(+)- and R(-)-prilocaine. The drug is clinically used as the racemate. This study examined the pharmacokinetics of the enantiomers after intravenous administration of the racemate. METHODS: Ten healthy male volunteers received 200 mg racemic prilocaine as a 10-min intravenous infusion. Blood samples were collected for 8 h after the start of the infusion. Plasma concentrations were measured by stereoselective high-performance liquid chromatography (HPLC). Unbound fractions of the enantiomers in blank blood samples, spiked with racemic prilocaine, were determined using equilibrium dialysis. RESULTS: The unbound fraction of R(-)-prilocaine (mean +/- SD, 70%+/-8%) was smaller (P < 0.05) than that of S(+)-prilocaine (73%+/-5%). The total plasma clearance of R(-)-prilocaine (2.57+/-0.46 l/min) was larger (P < 0.0001) than that of S(+)-prilocaine (1.91+/-0.30 l/min). The steady-state volume of distribution of R(-)-prilocaine (279+/-94 l) did not differ from that of S(+)-prilocaine (291+/-93 l). The terminal half-life of R(-)-prilocaine (87+/-27 min) was shorter (P < 0.05) than that of S(+)-prilocaine (124+/-64 min), as was the mean residence time of R(-)-prilocaine (108+/-30 min) compared with S(+)-prilocaine (155+/-59 min; P < 0.005). CONCLUSIONS: The pharmacokinetics of prilocaine are enantioselective. The difference in clearance is most likely a result of a difference in intrinsic metabolic clearance. The difference in the pharmacokinetics of the enantiomers of prilocaine does not seem to be clinically relevant.  (+info)

Topical anaesthesia of intact skin: liposome-encapsulated tetracaine vs EMLA. (2/141)

In this randomized, double-blind study, we have compared the ability of 5% liposome-encapsulated tetracaine (amethocaine) (LET) vs 5% eutectic mixture of local anaesthetics (EMLA) to produce local anaesthesia of intact skin in 40 healthy volunteers. Volunteers had both preparations applied to their forearms under an occlusive dressing for 1 h. Superficial anaesthesia was measured by a total of nine 1-mm pinpricks on each arm. Deeper anaesthesia was assessed by single insertion of a sterile 22-gauge needle to a depth of 3 mm and pain was reported on a visual analogue scale (VAS). If the volunteer perceived greater than four of the 1-mm pinpricks, the 3-mm insertion was not performed. Results showed that the number of pinpricks perceived was significantly less (P < 0.01) for LET (median 1.0; range 0-9) vs EMLA (1.5; 0-9). In volunteers who had deeper anaesthesia assessed, there was no significant difference (P = 0.065) in VAS scores for LET (mean 1.5 (SD 1.4); n = 34) vs EMLA (2.4 (2.1); n = 28). Overall anaesthetic effect, as ranked by all of the subjects, was significantly better for LET compared with EMLA (P = 0.024). We have demonstrated that when applied in equal volumes, 5% LET produced better superficial local anaesthesia than EMLA.  (+info)

Bone marrow harvesting using EMLA (eutectic mixture of local anaesthetics) cream, local anaesthesia and patient-controlled analgesia with alfentanil. (3/141)

Bone marrow harvesting (BMH) was performed on 40 consecutive allogeneic or autologous donors using EMLA (eutectic mixture of local anaesthetics), local anaesthesia (LA) and patient-controlled analgesia with alfentanil (PCA-A). The effect of alkalinizing the LA solution on reducing pain during LA infiltration in the presence of EMLA was also investigated. EMLA 10 g with occlusive dressing was applied to the harvest sites at least 60 min before BMH. The PCA device was programmed to deliver an intravenous loading dose of 15 microg/kg alfentanil, followed by a background alfentanil infusion of 0.05 microg/kg/min. Demand dose was 4 microg/kg and lockout time was 3 min. Donors were randomized to receive either alkalinized (n = 19) or non-alkalinized (n=21) LA solution (lignocaine 1% with 1:100000 adrenaline). While post-operative nausea and vomiting were the only side-effects, all donors in both groups reported satisfactory pain scores during LA infiltration and satisfactory overall intra-operative comfort scores. They completed BMH using either regimen successfully, found this technique acceptable and would recommend this form of anaesthesia to others. Alkalinizing the LA solution did not significantly improve the pain scores during LA infiltration in the presence of EMLA. In conclusion, BMH can be performed safely using EMLA, LA and PCA-A without major complications.  (+info)

Tetracaine gel vs EMLA cream for percutaneous anaesthesia in children. (4/141)

We have evaluated the anaesthetic effect of tetracaine gel 1 g, applied for 45 min, compared with EMLA cream 2 g, applied for 60 min, in a randomized, double-blind study in 60 children aged 3-15 yr. Venous cannulation was performed 15 min after removal of the EMLA cream (n = 20) and tetracaine gel (n = 20). Cannulation was performed up to 215 min after removal of the tetracaine gel in another 20 patients. Significantly lower pain scores were recorded by the children treated with tetracaine gel compared with EMLA cream (P < 0.02). Forty to 45% of children in the tetracaine groups reported no pain compared with only 10% in the EMLA group. Only minor adverse effects were observed. We conclude that tetracaine gel provided effective, rapid, long-lasting and safe local anaesthesia, and was significantly better than EMLA cream in reducing pain during venous cannulation in children using the recommended application periods for both formulations.  (+info)

A comparison of local anaesthetics for venepuncture. (5/141)

AIM: To compare the effectiveness of EMLA cream and Ametop gel in providing analgesia for venous cannulation. METHODS: Single blind study in 120 children. RESULTS: Both anaesthetic agents produced adequate analgesia. However, Ametop gel was more effective, with a statistically significant difference in the pain scores of the two groups (p < 0.05).  (+info)

Both EMLA and placebo cream reduced pain during extracorporeal piezoelectric shock wave lithotripsy with the Piezolith 2300. (6/141)

BACKGROUND: The objectives were to determine whether a eutectic mixture of local anesthetic (EMLA) or placebo cream reduces pain during extracorporeal piezoelectric shock wave lithotripsy (EPSWL), and to determine which of the components of the application (i.e., the occlusive dressing, the cream, or the local anesthetic) contributes to analgesia. METHODS: A randomized, double blind, crossover study (part 1) was performed in 12 patients who were scheduled for EPSWL procedures on an ambulatory basis who received the first treatment without any intervention and who had verbal pain scores of 70 or more (on a 0-to- 100 scale). For the next two treatments at 2-week intervals, patients were randomly assigned to receive either 10 g EMLA or 10 g placebo cream and then crossed over to receive the other. The cream and occlusive dressing were left in place and immersed in water throughout the procedure. Verbal numeric pain score was assessed at 5 min after receiving the maximal tolerable intensity of shock wave and at the end of the procedure. The study continued (part 2) in 202 ambulatory patients; 125 men and 77 women, American Society of Anesthesiologists physical status I and II, subjected to EPSWL were randomly allocated into five groups who received (1) nothing on the skin (control), (2) plastic occlusive dressing, (3) placebo cream and plastic occlusive dressing, (4) EMLA cream and plastic occlusive dressing, (5) EMLA cream and plastic occlusive dressing for 60 min to achieve cutaneous anesthesia, which was removed before EPSWL. Pain score was evaluated 10 min into the procedure and at the end of the procedure. RESULT: Both parts of the study showed that patients who received either EMLA or placebo cream with dressing throughout the procedure experienced less pain and tolerated higher energy levels compared with the control. Patients who received only pre-EPSWL cutaneous anesthesia of EMLA and who received only the occlusive dressing did not have a reduction in pain score. CONCLUSIONS: EMLA and placebo creams under occlusive dressing reduced pain during EPSWL. The presence of the cream itself as a coupling medium contributed to analgesia. This may be a useful, simple, safe, and economical adjuvant technique to reduce pain during immersion EPSWL.  (+info)

Evaluation of prilocaine for the reduction of pain associated with transmucosal anesthetic administration. (7/141)

This investigation evaluated the use and efficacy of prilocaine HCl (4% plain Citanest) for minimizing pain associated with the intraoral administration of local anesthesia. Clinical anecdotes support the hypothesis that prilocaine without a vasoconstrictor reduces pain during injection. To determine relative injection discomfort, use of 4% plain prilocaine was compared with use of 2% lidocaine with 1:100,000 epinephrine and 2% mepivacaine with 1:20,000 levonordefrin. Prior to routine endodontic procedures, 150 adult patients received 0.3 to 1.8 mL of local anesthetic via the same gauge needle without the use of a topical local anesthetic. Injection methods included buccal infiltration, labial infiltration, palatal infiltration, and inferior alveolar nerve block. Following each injection, patients were asked to describe the level of discomfort by scoring on a visual analog scale of 1 to 10, where 1 = painless and 10 = severe pain. Analyses via 2-way analysis of variance revealed no interaction between anesthetic and site of injection. However, there were statistically significant differences among the injection sites. Post hoc analysis revealed that prilocaine was associated with significantly less pain perception when compared to mepivacaine and lidocaine. These results suggest that differences in initial pain perception during transmucosal injection may be a function of the local anesthetic use, and prilocaine can produce less discomfort than the others tested.  (+info)

A randomised, double-blind, placebo-controlled, comparative study of topical skin analgesics and the anxiety and discomfort associated with venous cannulation. (8/141)

OBJECTIVES: To compare the effect of topical skin anaesthetic agents on the discomfort and anxiety associated with venous cannulation. DESIGN: Randomised, double-blind, placebo-controlled, within subject, volunteer trial. METHODS: 20 healthy volunteers underwent venous cannulation on three separate occasions having received topical skin application of either 4% amethocaine gel (Ametop), 5% eutectic mixture of lidocaine and prilocaine (EMLA) or E45 cream (placebo). Visual analogue and verbal rating scales were used to assess pain and anxiety associated with the venous cannulation, and anticipated anxiety for future cannulation, under each drug condition. RESULTS: Subjects were aged 22-53 years (mean 32.8 years). The mean visual analogue scores (VAS) for discomfort were found to be significantly lower (p< 0.001) with Ametop (VAS = 18mm) and EMLA (VAS = 29mm) compared with the control (VAS = 38mm). There was a positive correlation (R2 = 72%, p<0.001) between discomfort and the predicted anxiety if cannulation was to be repeated with the same cream. With the placebo a positive correlation (R2 = 19.8%, p = 0.05) was found between the level of anxiety before cannulation and the level of discomfort recorded. CONCLUSIONS: Ametop and EMLA topical anaesthetic agents produce effective skin analgesia for venous cannulation. The use of topical analgesia can reduce perceived anxiety about future cannulation procedures. This has application in the management of anxious patients undergoing intravenous sedation, suggesting that topical analgesia prior to venous cannulation may significantly aid anxiolysis.  (+info)

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When 60 g of lidocaine and prilocaine cream, 2.5%/2.5% was applied over 400 cm2 for 24 hours, peak blood levels of lidocaine are approximately 1/20 the systemic toxic level. Likewise, the maximum prilocaine level is about 1/36 the toxic level. In a pharmacokinetic study, lidocaine and prilocaine cream, 2.5%/2.5% was applied to penile skin in 20 adult male patients in doses ranging from 0.5 g to 3.3 g for 15 minutes. Plasma concentrations of lidocaine and prilocaine following lidocaine and prilocaine cream, 2.5%/2.5% application in this study were consistently low (2.5-16 ng/mL for lidocaine and 2.5-7 ng/mL for prilocaine). The application of lidocaine and prilocaine cream, 2.5%/2.5% to broken or inflamed skin, or to 2,000 cm2 or more of skin where more of both anesthetics are absorbed, could result in higher plasma levels that could, in susceptible individuals, produce a systemic pharmacologic response.. The absorption of lidocaine and prilocaine cream, 2.5%/2.5% applied to genital mucous ...
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Product Description 99.9% Prilocaine Powder Local Anesthetics For Anti Paining Prilocaine HCL Prilocaine Prilocaine Powerful Propitocaine HCL Local Anesthetic With Longer Duration CAS: 721-50-6 MF: C13H20N2O Assay: 99% min. Character: White crystalline powder Propitocaine HCl Name: Propitocaine HCL CAS: 1786-81-8 MF: C13H21ClN2O Assay: 99% min. Character: White crystalline powder Description: As local anesthetics, lidocaine same…
Prilocaine - WikipediaPrilocaine - Wikipedia
Prilocaine (/ˈpraɪləˌkeɪn/) is a local anesthetic of the amino amide type first prepared by Claes Tegner and Nils Löfgren. In its injectable form (trade name Citanest), it is often used in dentistry. It is also often combined with lidocaine as a topical preparation for dermal anesthesia (lidocaine/prilocaine or EMLA), for treatment of conditions like paresthesia. As it has low cardiac toxicity, it is commonly used for intravenous regional anaesthesia (IVRA). In some patients, ortho-toluidine, a metabolite of prilocaine, may cause methemoglobinemia, which may be treated with methylene blue. Prilocaine may also be contraindicated in people with sickle cell anemia, anemia, or symptomatic hypoxia. People with pseudocholinesterase deficiency may have difficulty metabolizing this anesthetic. It is given as a combination with the vasoconstrictor epinephrine under the trade name Citanest Forte. It is used as an eutectic mixture with lidocaine, 50% w/w, as lidocaine/prilocaine. The mixture is an ...
Efficacy Trial of Eutectic Lidocaine/Prilocaine Cream 5% (EMLA) for Analgesia Prior to Cryotherapy of Verrucae Plantaris - Full...Efficacy Trial of Eutectic Lidocaine/Prilocaine Cream 5% (EMLA) for Analgesia Prior to Cryotherapy of Verrucae Plantaris - Full...
Methodology:. The study is a single-centre, double-blind, randomized, placebo-controlled, parallel-group trial with one visit. The investigators planned to include at least 64 patients in 4 months. Adult patients (at least 21 years old) diagnosed with plantar warts are potential subjects for the study.. Once a potential subject is identified, the field investigator will assess him/her for eligibility to enter the study. Then, the potential subject will be provided with full and adequate verbal and written information about the nature, purpose, possible risks and benefits of the study. If the subject agrees to enroll into the study, a signed informed consent will be obtained from him/her.. All patients are randomly assigned by computer-generated randomization sequence to receive either eutectic lidocaine/prilocaine cream (EMLA)® 5% or placebo 60 mins prior to application of cryotherapy. The plantar warts are pared with shape blade before applying EMLA®or placebo cream. Based on the ...
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Emla cream is a local anesthetic (numbing medication) containing lidocaine and prilocaine. It works by blocking nerve signals in your body. Emla cream is used to numb normal intact skin or the membrane surfaces of the penis or vagina. Emla is used to prepare you for minor surgery or medical procedures on these areas.. Generic Emla (Lidocaine + Prilocaine 5g) € 18.52 pill - Mens Health, Skin Care, Surgery, Womens Health @ Online Pharmacy. Online Pharmacy
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Emla cream is a local anesthetic (numbing medication) containing lidocaine and prilocaine. It works by blocking nerve signals in your body. Emla cream is used to numb normal intact skin or the membrane surfaces of the penis or vagina. Emla is used to prepare you for minor surgery or medical procedures on these areas.. Generic Emla (Lidocaine + Prilocaine 5g) $ 19.99 pill - Mens Health, Skin Care, Surgery, Womens Health @ Fildena, Cenforce, Vidalista, Tadalista from Mydiscountpills.com. Cheap price on popular Indian brand names such as: Fildena, Cenforce, Vidalista, Tadalista and more! Full satisfaction of all Your desires :)
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Biol Neonate 1995; 68: 334-41. Abstract: EMLA (eutectic mixture of lidocaine and prilocaine) cream is currently not recommended for use in infants < 1 month of age because of the potential risk of methemoglobinemia as a result of the o-toluidine metabolite of prilocaine. We studied bioavailablitiy and changes in methemoglobin levels following topical penile exposure to 1 g of EMLA cream for 1 hour in piglets. Lidocaine, prilocaine, and o-toluidine concentrations were measured simultaneously using a high-performance liquid chromatography method. The systemic bioavailability of EMLA was low: 4.0 +/- (SD) 4.7% for lidocaine (range 0-13.6; n=8) and 7.2 +/- 5.7% for prilocaine (range 0-14.5; n=8). The ratio between exposure to o-toluidine with EMLA versus intravenous administration (i.e. AUC EMLA/ AUC IV; see text) was also low: 4.2 +/- 9.3% (range 0-28.6; n=9). The mean maximum methemaglobin value after intravenous administration was 1.23 +/- 0.64% (range 0.5-3.0; n=12) and after penile application ...
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Recent advances: Paediatric anaesthesia | The BMJRecent advances: Paediatric anaesthesia | The BMJ
One of the most unpleasant procedures for children in hospital is insertion of a venous cannula for induction of anaesthesia, taking blood samples, or administering fluid and drugs. To try to reduce the pain associated with the procedure a topically active local anaesthetic preparation is applied such as Emla cream (a mixture of 2.5 mg/ml of lignocaine and 2.5 mg/ml of prilocaine). To work properly Emla cream has to be applied at least an hour before the procedure,1 2 which means it is not suitable for emergency and some day case patients. Even when applied for 60 minutes it is effective in only 65% of children,3 although this proportion rises if it is left in place for 90-120 minutes.4 Emla cream also causes vasoconstriction at the site of application, which can make venepuncture difficult.5. The recent development and licensing of a topical cream made with the local anaesthetic amethocaine has greatly improved topical anaesthesia. Amethocaine has a much higher lipid solubility than Emla and ...
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TY - JOUR. T1 - APPLICAZIONI DELLA POMATA EMLA 5% PER ANESTESIA LOCALE IN CHIRURGIA PEDIATRICA AMBULATORIALE. AU - Zaccara, A.. AU - Spagnoli, A.. AU - Broggi, M.. AU - Silveri, M.. AU - Broggi, G.. PY - 1993/12/1. Y1 - 1993/12/1. N2 - The use of local anaesthesia has been advocated by most pediatric surgeons in order to cut down hospitalization costs as well as to avoid general anaesthesia. In 1992, 26 patients aged 4 to 14 years (avg. 8 years) underwent small surgical procedures with local anesthesia, obtained by the application of EMLA cream 60 to 120 minutes prior to the procedure. EMLA cream is aneutectic mixture of lidocaine and prilocaine with a meeting point at a lesser temperature than the two compounds separately. In this way, concentration of anaesthetics increases up to 80% in the emulsion droplets. This preparation enables small operations to be performed under local anaesthesia even in small children who can be safely treated as outpatients. Disadvantages due to the long time ...
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Numbing Cream What is ELMA Cream Used For? Cream - 5g Tube (No Dressings) is suitable if you plan to use occasionally and if you only need to numb a small area of skin (e. g. for immunisations or blood tests). A 5g tube is typically enough for two applications of Cream. Dressings are not included so if you choose this pack, you will need to obtain suitable dressings to cover the cream. Elma cream is perfect for children when it comes to their first inoculations and vaccinations. This product is safe for infants and makes the experience less unpleasant. Other Uses for ELMA Cream? As well as numbing you before blood tests, injections and inoculations, Elma Cream can be used for tattoos and tattoo removal. How does Numbing Cream Work? Cream contains prilocaine and li ine, two active ingredients that help numb the skin for at least two hours. When cream is applied to the skin, the li ine and prilocaine help prevent pain signals passing from that area to the brain thus helping to ease the pain otherwise
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There have been about 20 studies of analgesia for neonatal circumcision over the last two decades. Now a study in Canada (New England Journal of Medicine1997;336:1197-201) has shown a 2.5% lidocaine, 2.5% prilocaine cream (Emla cream) to be effective. In 59 babies randomised to this cream or placebo the analgesic cream was associated with up to 50% less facial activity at various points in the procedure and a significant reduction in time spent crying. There were no observed adverse effects and in particular the cream did not give rise to methaemoglobinaemia. Nevertheless Lucina just wonders how many adults would volunteer for circumcision under Emla cream analgesia.. Some 98% of all deaths in childhood occur in developing countries with pneumonia, diarrhoea, perinatal disorders, and measles being the chief causes (Lancet 1997;349:1269-76). The probability of dying in childhood is about 1% in industrialised countries and 22% in the developing world. In sub-Saharan Africa over half of all deaths ...
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TY - JOUR. T1 - Topical Anesthesia With EMLA Reduces Pain During Endomyocardial Biopsy. T2 - a Randomized Trial. AU - Leloudis, Dianne H.. AU - Kittleson, Michelle M.. AU - Felker, G. Michael. AU - Rosenberg, Paul B.. AU - Hernandez, Adrian F.. AU - Yager, Jonathan E.. AU - Russell, Stuart D.. PY - 2006/9. Y1 - 2006/9. N2 - Cardiac transplant recipients often anticipate and suffer varying degrees of discomfort during surveillance endomyocardial biopsy (EMBx). We performed a randomized, blinded, placebo-controlled trial to determine whether topical anesthetic was associated with reduced pain and to identify factors associated with increased pain perception during EMBx. In 225 EMBxs, use of the eutectic mixture of lidocaine and prilocaine (EMLA) decreased pain score (-7.3 compared with placebo; p = 0.04); the other significant predictors of increased pain scores were time to achieve access (+2.3 per minute; p = 0.001) and female gender (+12.7 compared with males; p = 0.003). Topical anesthetic ...
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Eutectic systems enhance the permeation of therapeutic agents across biological barriers, but the mechanism by which this occurs has not previously been elucidated. Using human skin it has proven difficult to isolate the fundamental effects of eutectic formation on molecule diffusion and partition from those that arise as a consequence of the simultaneous application of two agents. The aim of this work was to employ a model hydrophobic membrane to understand the fundamental permeation characteristics of two agents when applied as a eutectic mixture. Lidocaine and prilocaine were selected as model agents and infinite-dose permeation studies were carried out using pre-calibrated Franz diffusion cells with two thicknesses of silicone membrane. Membrane solubility was determined by HCl solution extraction and the membrane diffusion coefficients were calculated from the permeation lag-times. The maximum permeation enhancement was achieved using a eutectic mixture at a 0.7:0.3 prilocaine/lidocaine ...
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Oraqix (Lidocaine and Prilocaine Periodontal Gel): Uses, Dosage, Side Effects, Interactions, WarningOraqix (Lidocaine and Prilocaine Periodontal Gel): Uses, Dosage, Side Effects, Interactions, Warning
Spinal Anaesthesia with Hyperbaric Prilocaine in Day-Case Perianal Surgery: Randomised Controlled TrialSpinal Anaesthesia with Hyperbaric Prilocaine in Day-Case Perianal Surgery: Randomised Controlled Trial
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Lidocaine-Prilocaine (EMLA) Cream as Analgesia in Hysterosalpingography Practice - Full Text View - ClinicalTrials.govLidocaine-Prilocaine (EMLA) Cream as Analgesia in Hysterosalpingography Practice - Full Text View - ClinicalTrials.gov
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Lidocaine-prilocaine 2.5 % Price Comparisons - Discounts, Cost & CouponsLidocaine-prilocaine 2.5 % Price Comparisons - Discounts, Cost & Coupons
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Lidocaine/Prilocaine (EMLA Generic) - Pain Relief CreamLidocaine/Prilocaine (EMLA Generic) - Pain Relief Cream
Comparison of Topical Anesthetics for Radiofrequency Ablation of Achrocordons: Eutectic Mixture of Lignocaine/Prilocaine versus...Comparison of Topical Anesthetics for Radiofrequency Ablation of Achrocordons: Eutectic Mixture of Lignocaine/Prilocaine versus...
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CreamEffects of lidocaine and prilocaineLidocaine 2.5AnesthesiaMetabolite of prilocaineMethemoglobinemiaAnestheticAllergic reactionLocalEutecticGingivalBenzocaineMedicationNumb the skinNerveSignalsMedicinesOraqixBupivacainePeriodontal gelAbsorption of lidocaine and prilocaineMepivacaineInjectionSide effects of lidocaineAssayCream with lidocaineMechanism of actGenericAnalgesiaAnestheticEMLA PatchFelypressinTopical lidocaineAmide anestheticsEutectic MixtureAmino amide typeMountainside Medical EquipmentReactionsPatchLidocaine infiltrationDrugsNerve endingsDoseAnestheticsSpray
Cream34
Effects of lidocaine and prilocaine2
Lidocaine 2.51
Anesthesia1
Metabolite of prilocaine1
Methemoglobinemia1
Anesthetic5
Allergic reaction2
Local1
Eutectic1
Gingival1
Benzocaine1
Medication2
Numb the skin1
Nerve2
Signals1
Medicines1
Oraqix4
Bupivacaine3
Periodontal gel11
Absorption of lidocaine and prilocaine1
Mepivacaine2
Injection3
Side effects of lidocaine1
Assay5
  • Anti Pain Local Anaesthetic Powder Prilocaine Base CAS 721-50-6 Prilocaine Details: Product Name Prilocaine Prilocaine CAS 721-50-6 Prilocaine MF C13H20N2O Prilocaine MW 220.31 Apperance white Solid Assay 99% Grade Pharmaceutical Grade Delivery time. (ccnmag.com)
  • Product Name Prilocaine CAS 721-50-6 EINECS 211-957-0 MF C13H20N2O MW 220.31 Assay 99% Appearance White powder Grade Pharmaceutical Grade What is Prilocaine ? (ccnmag.com)
  • Assay Dissolve about 500 mg of Prilocaine Hydrochloride, accurately weighed, in 50 mL of glacial acetic acid, add 10 mL of mercuric acetate TS and 2 drops of crystal violet TS , and titrate with 0.1 N perchloric acid VS to a blue-green endpoint. (drugfuture.com)
  • The chromatogram of the Assay preparation obtained as directed in the Assay for prilocaine hydrochloride exhibits a major peak for prilocaine, the retention time of which corresponds to that exhibited in the chromatogram of the Standard preparation obtained as directed in the Assay for prilocaine hydrochloride . (drugfuture.com)
  • 31 Molecular Structure Payment Method Western Union, Bank Transfer, MoneyGram, Bitcoin, Litecoin COA Product Name Prilocaine Alias 2-(propylamino)-o-propionotoluidid, xylonest Assay (%) ≥ 99.00 Odor Characteristic Color White crystalline powder Melting. (chinameasure.com)
Cream with lidocaine1
Mechanism of act1
Generic7
Analgesia7
Anesthetic19
EMLA Patch1
  • While this formulation was not approved by the FDA, a similar product, Promescent, is available over-the-counter in the U.S. Lidocaine/prilocaine eutectic mixture is marketed as a 5% oil-in-water emulsion incorporated in a cream base (EMLA cream) or a cellulose disk (EMLA patch). (wikipedia.org)
Felypressin1
Topical lidocaine2
Amide anesthetics1
Eutectic Mixture9
Amino amide type1
  • Prilocaine is an amino amide type of local anaesthetic with a fast onset of action. (maylips.com)
Mountainside Medical Equipment1
Reactions3
Patch2
Lidocaine infiltration2
Drugs4
Nerve endings1
Dose1
  • Literature suggests a dose ranging between 40 and 60 mg of prilocaine for lower extremities and lower abdominal procedures lasting up to 90 min, whereas a dose ranging from 10 to 30 mg is appropriate for perineal surgery. (dovepress.com)
Anesthetics5
Spray4
CITANEST FORTE DENTAL (prilocaine hcl and epinephrine injection, solution) | Healthgrades.com
CITANEST FORTE DENTAL (prilocaine hcl and epinephrine injection, solution) | Healthgrades.com (healthgrades.com)
Anesthetic cream best for relieving vaccination pain in infants
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Buy Emla Cream 5% 30g Tube Online at Chemist Warehouse®
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Prilocaine | Memorial Sloan Kettering Cancer Center
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DailyMed - DERMACINRX PRIZOPAK- lidocaine and prilocaine kit
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Glucomannan|Drospirenone|Lidocaine Base|Prilocaine Hcl--EASYBUYER LTD.(Shanghai Renyoung Pharmaceutical Co., Ltd.).
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Find drug pricing | AARP Prescription Discounts
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Dr. Numb Topical Anesthetic Numbing Cream for Tattoos, Waxing, Needle Injection Pain- Lidocaine & Prilocaine
Dr. Numb Topical Anesthetic Numbing Cream for Tattoos, Waxing, Needle Injection Pain- Lidocaine & Prilocaine (shop.buydrnumb.com)
Plus it
Plus it (cfp.ca)
Course Content - #55252: Medication Use in Dentistry - NetCE
Course Content - #55252: Medication Use in Dentistry - NetCE (netce.com)
Prilocaine | Springer for Research & Development
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Periodontic Specialty Catalog - September 2013
Periodontic Specialty Catalog - September 2013 (nxtbook.com)
Local Anesthetics: Introduction and History, Mechanism of Action, Chemical Structure
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Oraqix - FDA prescribing information, side effects and uses
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Local Anesthesia With Sedation: Overview, Indications, Technique
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Nitrate/Nitrite Toxicity: Clinical Assessment - Evaluation | Environmental Medicine | ATSDR
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Methemoglobin Levels in Generally Anesthetized Pediatric Dental Patients Receiving Local Anesthetics - Full Text View -...
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Rythmol SR Advanced Patient Information - Drugs.com
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Inderal LA Advanced Patient Information - Drugs.com
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Laser Hair Removal Treatment & Management: Medical Therapy, Surgical Therapy, Preoperative Details
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Local Anesthetic Toxicity Treatment & Management: Approach Considerations, Treatment of Central Nervous System Toxicity,...
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Local Anesthetic Toxicity: Practice Essentials, Background, Pathophysiology
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Laser Hair Removal: Practice Essentials, History of the Procedure, Problem
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Local Anesthetic Toxicity Workup: Approach Considerations
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Unflem 250 MG Suspension - Uses, Dosage, Side Effects, Price, Composition | Practo
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July 2012 - Volume 23 - Issue 4 : Journal of Craniofacial Surgery
July 2012 - Volume 23 - Issue 4 : Journal of Craniofacial Surgery (journals.lww.com)
February 2007 - Volume 104 - Issue 2 : Anesthesia & Analgesia
February 2007 - Volume 104 - Issue 2 : Anesthesia & Analgesia (journals.lww.com)
Phenazopyridine (Professional Patient Advice) - Drugs.com
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Basic Excisional Surgery: Overview, Anesthesia, Equipment
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