Drugs that block nerve conduction when applied locally to nerve tissue in appropriate concentrations. They act on any part of the nervous system and on every type of nerve fiber. In contact with a nerve trunk, these anesthetics can cause both sensory and motor paralysis in the innervated area. Their action is completely reversible. (From Gilman AG, et. al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed) Nearly all local anesthetics act by reducing the tendency of voltage-dependent sodium channels to activate.
A local anesthetic that is chemically related to BUPIVACAINE but pharmacologically related to LIDOCAINE. It is indicated for infiltration, nerve block, and epidural anesthesia. Mepivacaine is effective topically only in large doses and therefore should not be used by this route. (From AMA Drug Evaluations, 1994, p168)
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The presence of methemoglobin in the blood, resulting in cyanosis. A small amount of methemoglobin is present in the blood normally, but injury or toxic agents convert a larger proportion of hemoglobin into methemoglobin, which does not function reversibly as an oxygen carrier. Methemoglobinemia may be due to a defect in the enzyme NADH methemoglobin reductase (an autosomal recessive trait) or to an abnormality in hemoglobin M (an autosomal dominant trait). (Dorland, 27th ed)
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The active sympathomimetic hormone from the ADRENAL MEDULLA. It stimulates both the alpha- and beta- adrenergic systems, causes systemic VASOCONSTRICTION and gastrointestinal relaxation, stimulates the HEART, and dilates BRONCHI and cerebral vessels. It is used in ASTHMA and CARDIAC FAILURE and to delay absorption of local ANESTHETICS.
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International Classification of Diseases
A system of categories to which morbid entries are assigned according to established criteria. Included is the entire range of conditions in a manageable number of categories, grouped to facilitate mortality reporting. It is produced by the World Health Organization (From ICD-10, p1). The Clinical Modifications, produced by the UNITED STATES DEPT. OF HEALTH AND HUMAN SERVICES, are larger extensions used for morbidity and general epidemiological purposes, primarily in the U.S.
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Drugs manufactured and sold with the intent to misrepresent its origin, authenticity, chemical composition, and or efficacy. Counterfeit drugs may contain inappropriate quantities of ingredients not listed on the label or package. In order to further deceive the consumer, the packaging, container, or labeling, may be inaccurate, incorrect, or fake.
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Drug-Related Side Effects and Adverse Reactions
The application of drug preparations to the surfaces of the body, especially the skin (ADMINISTRATION, CUTANEOUS) or mucous membranes. This method of treatment is used to avoid systemic side effects when high doses are required at a localized area or as an alternative systemic administration route, to avoid hepatic processing for example.
Pharmacokinetics of prilocaine after intravenous administration in volunteers: enantioselectivity. (1/141)BACKGROUND: Prilocaine exists in two stereoisomeric configurations, the enantiomers S(+)- and R(-)-prilocaine. The drug is clinically used as the racemate. This study examined the pharmacokinetics of the enantiomers after intravenous administration of the racemate. METHODS: Ten healthy male volunteers received 200 mg racemic prilocaine as a 10-min intravenous infusion. Blood samples were collected for 8 h after the start of the infusion. Plasma concentrations were measured by stereoselective high-performance liquid chromatography (HPLC). Unbound fractions of the enantiomers in blank blood samples, spiked with racemic prilocaine, were determined using equilibrium dialysis. RESULTS: The unbound fraction of R(-)-prilocaine (mean +/- SD, 70%+/-8%) was smaller (P < 0.05) than that of S(+)-prilocaine (73%+/-5%). The total plasma clearance of R(-)-prilocaine (2.57+/-0.46 l/min) was larger (P < 0.0001) than that of S(+)-prilocaine (1.91+/-0.30 l/min). The steady-state volume of distribution of R(-)-prilocaine (279+/-94 l) did not differ from that of S(+)-prilocaine (291+/-93 l). The terminal half-life of R(-)-prilocaine (87+/-27 min) was shorter (P < 0.05) than that of S(+)-prilocaine (124+/-64 min), as was the mean residence time of R(-)-prilocaine (108+/-30 min) compared with S(+)-prilocaine (155+/-59 min; P < 0.005). CONCLUSIONS: The pharmacokinetics of prilocaine are enantioselective. The difference in clearance is most likely a result of a difference in intrinsic metabolic clearance. The difference in the pharmacokinetics of the enantiomers of prilocaine does not seem to be clinically relevant. (+info)
Topical anaesthesia of intact skin: liposome-encapsulated tetracaine vs EMLA. (2/141)In this randomized, double-blind study, we have compared the ability of 5% liposome-encapsulated tetracaine (amethocaine) (LET) vs 5% eutectic mixture of local anaesthetics (EMLA) to produce local anaesthesia of intact skin in 40 healthy volunteers. Volunteers had both preparations applied to their forearms under an occlusive dressing for 1 h. Superficial anaesthesia was measured by a total of nine 1-mm pinpricks on each arm. Deeper anaesthesia was assessed by single insertion of a sterile 22-gauge needle to a depth of 3 mm and pain was reported on a visual analogue scale (VAS). If the volunteer perceived greater than four of the 1-mm pinpricks, the 3-mm insertion was not performed. Results showed that the number of pinpricks perceived was significantly less (P < 0.01) for LET (median 1.0; range 0-9) vs EMLA (1.5; 0-9). In volunteers who had deeper anaesthesia assessed, there was no significant difference (P = 0.065) in VAS scores for LET (mean 1.5 (SD 1.4); n = 34) vs EMLA (2.4 (2.1); n = 28). Overall anaesthetic effect, as ranked by all of the subjects, was significantly better for LET compared with EMLA (P = 0.024). We have demonstrated that when applied in equal volumes, 5% LET produced better superficial local anaesthesia than EMLA. (+info)
Bone marrow harvesting using EMLA (eutectic mixture of local anaesthetics) cream, local anaesthesia and patient-controlled analgesia with alfentanil. (3/141)Bone marrow harvesting (BMH) was performed on 40 consecutive allogeneic or autologous donors using EMLA (eutectic mixture of local anaesthetics), local anaesthesia (LA) and patient-controlled analgesia with alfentanil (PCA-A). The effect of alkalinizing the LA solution on reducing pain during LA infiltration in the presence of EMLA was also investigated. EMLA 10 g with occlusive dressing was applied to the harvest sites at least 60 min before BMH. The PCA device was programmed to deliver an intravenous loading dose of 15 microg/kg alfentanil, followed by a background alfentanil infusion of 0.05 microg/kg/min. Demand dose was 4 microg/kg and lockout time was 3 min. Donors were randomized to receive either alkalinized (n = 19) or non-alkalinized (n=21) LA solution (lignocaine 1% with 1:100000 adrenaline). While post-operative nausea and vomiting were the only side-effects, all donors in both groups reported satisfactory pain scores during LA infiltration and satisfactory overall intra-operative comfort scores. They completed BMH using either regimen successfully, found this technique acceptable and would recommend this form of anaesthesia to others. Alkalinizing the LA solution did not significantly improve the pain scores during LA infiltration in the presence of EMLA. In conclusion, BMH can be performed safely using EMLA, LA and PCA-A without major complications. (+info)
Tetracaine gel vs EMLA cream for percutaneous anaesthesia in children. (4/141)We have evaluated the anaesthetic effect of tetracaine gel 1 g, applied for 45 min, compared with EMLA cream 2 g, applied for 60 min, in a randomized, double-blind study in 60 children aged 3-15 yr. Venous cannulation was performed 15 min after removal of the EMLA cream (n = 20) and tetracaine gel (n = 20). Cannulation was performed up to 215 min after removal of the tetracaine gel in another 20 patients. Significantly lower pain scores were recorded by the children treated with tetracaine gel compared with EMLA cream (P < 0.02). Forty to 45% of children in the tetracaine groups reported no pain compared with only 10% in the EMLA group. Only minor adverse effects were observed. We conclude that tetracaine gel provided effective, rapid, long-lasting and safe local anaesthesia, and was significantly better than EMLA cream in reducing pain during venous cannulation in children using the recommended application periods for both formulations. (+info)
A comparison of local anaesthetics for venepuncture. (5/141)AIM: To compare the effectiveness of EMLA cream and Ametop gel in providing analgesia for venous cannulation. METHODS: Single blind study in 120 children. RESULTS: Both anaesthetic agents produced adequate analgesia. However, Ametop gel was more effective, with a statistically significant difference in the pain scores of the two groups (p < 0.05). (+info)
Both EMLA and placebo cream reduced pain during extracorporeal piezoelectric shock wave lithotripsy with the Piezolith 2300. (6/141)BACKGROUND: The objectives were to determine whether a eutectic mixture of local anesthetic (EMLA) or placebo cream reduces pain during extracorporeal piezoelectric shock wave lithotripsy (EPSWL), and to determine which of the components of the application (i.e., the occlusive dressing, the cream, or the local anesthetic) contributes to analgesia. METHODS: A randomized, double blind, crossover study (part 1) was performed in 12 patients who were scheduled for EPSWL procedures on an ambulatory basis who received the first treatment without any intervention and who had verbal pain scores of 70 or more (on a 0-to- 100 scale). For the next two treatments at 2-week intervals, patients were randomly assigned to receive either 10 g EMLA or 10 g placebo cream and then crossed over to receive the other. The cream and occlusive dressing were left in place and immersed in water throughout the procedure. Verbal numeric pain score was assessed at 5 min after receiving the maximal tolerable intensity of shock wave and at the end of the procedure. The study continued (part 2) in 202 ambulatory patients; 125 men and 77 women, American Society of Anesthesiologists physical status I and II, subjected to EPSWL were randomly allocated into five groups who received (1) nothing on the skin (control), (2) plastic occlusive dressing, (3) placebo cream and plastic occlusive dressing, (4) EMLA cream and plastic occlusive dressing, (5) EMLA cream and plastic occlusive dressing for 60 min to achieve cutaneous anesthesia, which was removed before EPSWL. Pain score was evaluated 10 min into the procedure and at the end of the procedure. RESULT: Both parts of the study showed that patients who received either EMLA or placebo cream with dressing throughout the procedure experienced less pain and tolerated higher energy levels compared with the control. Patients who received only pre-EPSWL cutaneous anesthesia of EMLA and who received only the occlusive dressing did not have a reduction in pain score. CONCLUSIONS: EMLA and placebo creams under occlusive dressing reduced pain during EPSWL. The presence of the cream itself as a coupling medium contributed to analgesia. This may be a useful, simple, safe, and economical adjuvant technique to reduce pain during immersion EPSWL. (+info)
Evaluation of prilocaine for the reduction of pain associated with transmucosal anesthetic administration. (7/141)This investigation evaluated the use and efficacy of prilocaine HCl (4% plain Citanest) for minimizing pain associated with the intraoral administration of local anesthesia. Clinical anecdotes support the hypothesis that prilocaine without a vasoconstrictor reduces pain during injection. To determine relative injection discomfort, use of 4% plain prilocaine was compared with use of 2% lidocaine with 1:100,000 epinephrine and 2% mepivacaine with 1:20,000 levonordefrin. Prior to routine endodontic procedures, 150 adult patients received 0.3 to 1.8 mL of local anesthetic via the same gauge needle without the use of a topical local anesthetic. Injection methods included buccal infiltration, labial infiltration, palatal infiltration, and inferior alveolar nerve block. Following each injection, patients were asked to describe the level of discomfort by scoring on a visual analog scale of 1 to 10, where 1 = painless and 10 = severe pain. Analyses via 2-way analysis of variance revealed no interaction between anesthetic and site of injection. However, there were statistically significant differences among the injection sites. Post hoc analysis revealed that prilocaine was associated with significantly less pain perception when compared to mepivacaine and lidocaine. These results suggest that differences in initial pain perception during transmucosal injection may be a function of the local anesthetic use, and prilocaine can produce less discomfort than the others tested. (+info)
A randomised, double-blind, placebo-controlled, comparative study of topical skin analgesics and the anxiety and discomfort associated with venous cannulation. (8/141)OBJECTIVES: To compare the effect of topical skin anaesthetic agents on the discomfort and anxiety associated with venous cannulation. DESIGN: Randomised, double-blind, placebo-controlled, within subject, volunteer trial. METHODS: 20 healthy volunteers underwent venous cannulation on three separate occasions having received topical skin application of either 4% amethocaine gel (Ametop), 5% eutectic mixture of lidocaine and prilocaine (EMLA) or E45 cream (placebo). Visual analogue and verbal rating scales were used to assess pain and anxiety associated with the venous cannulation, and anticipated anxiety for future cannulation, under each drug condition. RESULTS: Subjects were aged 22-53 years (mean 32.8 years). The mean visual analogue scores (VAS) for discomfort were found to be significantly lower (p< 0.001) with Ametop (VAS = 18mm) and EMLA (VAS = 29mm) compared with the control (VAS = 38mm). There was a positive correlation (R2 = 72%, p<0.001) between discomfort and the predicted anxiety if cannulation was to be repeated with the same cream. With the placebo a positive correlation (R2 = 19.8%, p = 0.05) was found between the level of anxiety before cannulation and the level of discomfort recorded. CONCLUSIONS: Ametop and EMLA topical anaesthetic agents produce effective skin analgesia for venous cannulation. The use of topical analgesia can reduce perceived anxiety about future cannulation procedures. This has application in the management of anxious patients undergoing intravenous sedation, suggesting that topical analgesia prior to venous cannulation may significantly aid anxiolysis. (+info)
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Prilocaine (/ˈpraɪləˌkeɪn/) is a local anesthetic of the amino amide type first prepared by Claes Tegner and Nils Löfgren. In its injectable form (trade name Citanest), it is often used in dentistry. It is also often combined with lidocaine as a topical preparation for dermal anesthesia (lidocaine/prilocaine or EMLA), for treatment of conditions like paresthesia. As it has low cardiac toxicity, it is commonly used for intravenous regional anaesthesia (IVRA). In some patients, ortho-toluidine, a metabolite of prilocaine, may cause methemoglobinemia, which may be treated with methylene blue. Prilocaine may also be contraindicated in people with sickle cell anemia, anemia, or symptomatic hypoxia. People with pseudocholinesterase deficiency may have difficulty metabolizing this anesthetic. It is given as a combination with the vasoconstrictor epinephrine under the trade name Citanest Forte. It is used as an eutectic mixture with lidocaine, 50% w/w, as lidocaine/prilocaine. The mixture is an ...
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Methodology:. The study is a single-centre, double-blind, randomized, placebo-controlled, parallel-group trial with one visit. The investigators planned to include at least 64 patients in 4 months. Adult patients (at least 21 years old) diagnosed with plantar warts are potential subjects for the study.. Once a potential subject is identified, the field investigator will assess him/her for eligibility to enter the study. Then, the potential subject will be provided with full and adequate verbal and written information about the nature, purpose, possible risks and benefits of the study. If the subject agrees to enroll into the study, a signed informed consent will be obtained from him/her.. All patients are randomly assigned by computer-generated randomization sequence to receive either eutectic lidocaine/prilocaine cream (EMLA)® 5% or placebo 60 mins prior to application of cryotherapy. The plantar warts are pared with shape blade before applying EMLA®or placebo cream. Based on the ...
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Biol Neonate 1995; 68: 334-41. Abstract: EMLA (eutectic mixture of lidocaine and prilocaine) cream is currently not recommended for use in infants < 1 month of age because of the potential risk of methemoglobinemia as a result of the o-toluidine metabolite of prilocaine. We studied bioavailablitiy and changes in methemoglobin levels following topical penile exposure to 1 g of EMLA cream for 1 hour in piglets. Lidocaine, prilocaine, and o-toluidine concentrations were measured simultaneously using a high-performance liquid chromatography method. The systemic bioavailability of EMLA was low: 4.0 +/- (SD) 4.7% for lidocaine (range 0-13.6; n=8) and 7.2 +/- 5.7% for prilocaine (range 0-14.5; n=8). The ratio between exposure to o-toluidine with EMLA versus intravenous administration (i.e. AUC EMLA/ AUC IV; see text) was also low: 4.2 +/- 9.3% (range 0-28.6; n=9). The mean maximum methemaglobin value after intravenous administration was 1.23 +/- 0.64% (range 0.5-3.0; n=12) and after penile application ...
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Emla cream contains two active ingredients: prilocaine and lidocaine, which are both local anaesthetics. They are used to numb areas that would otherwise feel pain.. Sensitivity is caused by the stimulation of the pain receptors at the end of the nerves. The stimulation causes the entry of sodium to the nerve ending, causing an electric signal to build up in the nerve, which when big enough, will be passed along the nerves to the brain.. Lidocaine and prilocaine temporarily block the pathway of the pain signals along the nerves by stopping the entry of sodium in the nerve endings at the site. This prevents the build-up of an electric signal and the passing along nerve fibres to the brain.. When Emla cream is applied to the skin, the lidocaine and prilocaine prevent the signals from passing from that area to the brain. This means that sensitivity is decreased and when used on the penis, it can help a man to take longer to ejaculate.. ...
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Lidocaine/prilocaine cream is a topical anesthetic commonly used in pediatric and dermatologic practice to obtain local anesthesia. Common side effects include: transient skin blanching, erythema, urticaria, allergic contact dermatitis, irritant contact dermatitis, and hyperpigmentation. The authors report a petechial and purpuric reaction after the application of lidocaine/prilocaine cream. This is a rare side effect, since to our knowledge only few case reports have been documented in literature.
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Minor dermal procedures (eg, IV cannulation, venipuncture): apply 2.5g in a thick layer with occlusion over 20-25cm2 for at least 1hr. Major dermal procedures (eg, skin graft harvesting): apply 2g per 10cm2 in a thick layer with occlusion for at least 2hrs. Pretreatment before local anesthetic infiltration on adult male genital skin: apply 1g per 10cm2 in a thick layer with occlusion for 15mins. Minor procedures on female external genitalia (eg, wart removal, local anesthetic infiltration): apply 5-10g in a thick layer for 5-10mins; may occlude to help keep cream in place.. ...
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The results of this study show that both topical anaesthetic preparations provide effective anaesthesia for venous cannulation in children.. EMLA cream produced more blanching of the skin and Ametop gel more erythema owing to the different actions of the anaesthetic agents, the lignocaine and prilocaine in EMLA cream being predominantly vasoconstrictive and amethocaine a vasodilator. The difference in local skin reaction did not, however, appear to influence the number of attempts needed for successful venous cannulation.. In this study, 72% of children in the Ametop group exhibited either no response or a mild facial grimace on cannulation compared with 55% of children in the EMLA group. Overall the children in the Ametop group showed significantly less pain than the EMLA group.. The results of this study confirm previous reports3 4that Ametop gel provides more effective anaesthesia for venous cannulation in a significantly higher proportion of children than does EMLA cream.. ...
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Recent advances: Paediatric anaesthesia | The BMJ
One of the most unpleasant procedures for children in hospital is insertion of a venous cannula for induction of anaesthesia, taking blood samples, or administering fluid and drugs. To try to reduce the pain associated with the procedure a topically active local anaesthetic preparation is applied such as Emla cream (a mixture of 2.5 mg/ml of lignocaine and 2.5 mg/ml of prilocaine). To work properly Emla cream has to be applied at least an hour before the procedure,1 2 which means it is not suitable for emergency and some day case patients. Even when applied for 60 minutes it is effective in only 65% of children,3 although this proportion rises if it is left in place for 90-120 minutes.4 Emla cream also causes vasoconstriction at the site of application, which can make venepuncture difficult.5. The recent development and licensing of a topical cream made with the local anaesthetic amethocaine has greatly improved topical anaesthesia. Amethocaine has a much higher lipid solubility than Emla and ...
APPLICAZIONI DELLA POMATA EMLA 5% PER ANESTESIA LOCALE IN CHIRURGIA PEDIATRICA AMBULATORIALE<...
TY - JOUR. T1 - APPLICAZIONI DELLA POMATA EMLA 5% PER ANESTESIA LOCALE IN CHIRURGIA PEDIATRICA AMBULATORIALE. AU - Zaccara, A.. AU - Spagnoli, A.. AU - Broggi, M.. AU - Silveri, M.. AU - Broggi, G.. PY - 1993/12/1. Y1 - 1993/12/1. N2 - The use of local anaesthesia has been advocated by most pediatric surgeons in order to cut down hospitalization costs as well as to avoid general anaesthesia. In 1992, 26 patients aged 4 to 14 years (avg. 8 years) underwent small surgical procedures with local anesthesia, obtained by the application of EMLA cream 60 to 120 minutes prior to the procedure. EMLA cream is aneutectic mixture of lidocaine and prilocaine with a meeting point at a lesser temperature than the two compounds separately. In this way, concentration of anaesthetics increases up to 80% in the emulsion droplets. This preparation enables small operations to be performed under local anaesthesia even in small children who can be safely treated as outpatients. Disadvantages due to the long time ...
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There have been about 20 studies of analgesia for neonatal circumcision over the last two decades. Now a study in Canada (New England Journal of Medicine1997;336:1197-201) has shown a 2.5% lidocaine, 2.5% prilocaine cream (Emla cream) to be effective. In 59 babies randomised to this cream or placebo the analgesic cream was associated with up to 50% less facial activity at various points in the procedure and a significant reduction in time spent crying. There were no observed adverse effects and in particular the cream did not give rise to methaemoglobinaemia. Nevertheless Lucina just wonders how many adults would volunteer for circumcision under Emla cream analgesia.. Some 98% of all deaths in childhood occur in developing countries with pneumonia, diarrhoea, perinatal disorders, and measles being the chief causes (Lancet 1997;349:1269-76). The probability of dying in childhood is about 1% in industrialised countries and 22% in the developing world. In sub-Saharan Africa over half of all deaths ...
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Frenulectomy of the penis is a surgical procedure for cutting and removal of the frenulum of prepuce of penis, to correct a condition known as frenulum breve. This condition prevents the full retraction of the foreskin with or without an erection. It is a simple and normally painless procedure that is performed in a urologists office. First the physician applies a local anesthetic, such as lidocaine/prilocaine cream on the frenulum and surrounding area. In half hour he checks to see if the patient has any feeling there. If not he proceeds with the procedure, otherwise he may recommend that it be performed in a hospital, with stronger anesthesia. Once the frenulum is cut, the physician applies stitches to close the wound. The patient is given a prescription for pain killers to take in case there is pain afterwards, but usually the only discomfort is from the pricking of the stitches on the foreskin. Once the stitches are removed, in about a week, normal sexual activity can resume. Guardian ...
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The high effectiveness of this anesthetic cream is ensured by the optimal percentage of active ingredients - lidocaine and prilocaine, in combination with epinephrine for vasoconstrictor action and gentamicin, which has antibacterial and anti-inflammatory effects. The non-greasy hypoallergenic base of the cream allows you to evenly distribute the product and at the same time softens the skin for the comfort of the client and the convenience of the master. For primary anesthesia, the cream must be applied to previously cleaned and dried skin, rub and cover with a film. The exposure time depends on the type of skin, the depth of the necessary anesthesia and the duration of the procedure - from 15 minutes. If during pain the need for additional anesthesia has arisen, you can reapply the anesthetic cream for a shorter time.. ...
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Citanest (prilocaine). *Diprivan (propofol). *EMLA (lidocaine/prilocaine). *Marcaine/Sensorcaine (bupivacaine). *Naropin ( ...
Adams V.; Marley J.; McCarroll C. (November 2007). "Prilocaine induced methaemoglobinaemia in a medically compromised patient. ...
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Prilocaine is also widely used, although it is not formally approved for tumescent anesthesia in the USA. A combination of ... Kendler, Michael; Simon, Jan C.; Wetzig, Tino (June 2013). "Local anesthesia with lidocaine and prilocaine, using the tumescent ... A double-blind randomized intraindividual study of lidocaine versus prilocaine in tumescent anesthesia for liposuction revealed ... intraindividual comparison study of the efficacy of prilocaine and lidocaine in tumescent local anesthesia". Dermatology (Basel ...
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Lidocaine and Prilocaine Cream USP, 2.5%/2.5%. Home/Lidocaine and Prilocaine Cream USP, 2.5%/2.5% ... Lidocaine and prilocaine cream USP, 2.5%/2.5% (a eutectic mixture of lidocaine 2.5% and prilocaine 2.5%) is indicated as a ... Lidocaine and prilocaine have been shown to inhibit viral and bacterial growth. The effect of lidocaine and prilocaine cream on ... Lidocaine and prilocaine are amide-type local anesthetic agents. Both lidocaine and prilocaine stabilize neuronal membranes by ...
OraqixMethemoglobinemiaHydrochloride and epinephrine bitartrateHyperbaric prilocaineBupivacaineAnesthesiaPeriodontal gelEffects of lidocaine and prilocaineInjectionLignocaineMepivacaineDosageSide effects of lidocaineGenericMechanism of actDermalGingivalFelypressinTopical lidocaineAmide anestheticsMedicationAllergicMountainside Medical EquipmentDrugsAssayGramPatchLidocaine infiltrationNerve endingsAnestheticsAnalgesiaEutectic mixturePowderAmino amideDental
- Lidocaine and prilocaine (DermacinRx, Prizopak, EMLA, Leva Set, Lidopril, Livixil Pak, LP Lite Pak, Oraqix, Relador Pak, Venipuncture CPI) is a local topical anesthetic cream used on normal intact skin and genital mucous areas prior to minor medical procedures. (medicinenet.com)
- The Oraqix single-use glass cartridges deliver up to 1.7g (1.7mL) of gel (42.5 mg of lidocaine and 42.5 mg of prilocaine). (rxlist.com)
- Each gram of Oraqix contains 25-mg lidocaine base and 25-mg prilocaine base. (rxlist.com)
- Oraqix (lidocaine and prilocaine periodontal gel), 2.5%/2.5%, is supplied in dental cartridges that provide 1.7g gel. (rxlist.com)
- Prilocaine may contribute to formation of methemoglobin in patients treated with other drugs known to cause methemoglobinemia . (medicinenet.com)
- Before lidocaine and prilocaine topical is applied, tell your doctor if you have liver disease, a history of allergic reaction to lidocaine or prilocaine, or a personal or family history of methemoglobinemia, or any genetic enzyme deficiency. (emedicinehealth.com)
- Too much Emla ( lidocaine and prilocaine ) could possibly cause methemoglobinemia which is a condition where the blood does not carry oxygen as it should. (healthtap.com)
- Prilocaine and lidocaine are classified as amide-type local anesthetics for which serious adverse effects include methemoglobinemia. (aspetjournals.org)
- Although the hydrolyzed metabolites of prilocaine ( o -toluidine) and lidocaine (2,6-xylidine) have been suspected to induce methemoglobinemia, the metabolic enzymes that are involved remain uncharacterized. (aspetjournals.org)
- In the present study, we aimed to identify the human enzymes that are responsible for prilocaine- and lidocaine-induced methemoglobinemia. (aspetjournals.org)
- Collectively, we found that the metabolites produced by human CES-, CYP2E1-, and CYP3A4-mediated metabolism were involved in prilocaine- and lidocaine-induced methemoglobinemia. (aspetjournals.org)
- In some patients, ortho-toluidine, a metabolite of prilocaine, may cause methemoglobinemia, which may be treated with methylene blue. (chinalane.org)
- In this clinical brief, three cases of transient neonatal methemoglobinemia, caused by maternal pudendal anesthesia with prilocaine, are reported. (readbyqxmd.com)
- Because the metabolite (ortho-toluidine) of Prilocaine may cause methemoglobinemia, it is not intended for patients with such disorders, including other blood disorders: anemia, sickle cell anemia, porphyria in children, or symptomatic hypoxia. (maylips.com)
- Prilocaine was withdrawn from use in the US because it may induce methemoglobinemia, a disorder characterized with elevated levels of methemoglobin in the blood. (maylips.com)
Hydrochloride and epinephrine bitartrate2
- Available as prilocaine hydrochloride and as fixed combination containing prilocaine hydrochloride and epinephrine bitartrate. (drugs.com)
- Prilocaine and Epinephrine Injection is a sterile solution prepared from Prilocaine Hydrochloride and Epinephrine with the aid of Hydrochloric Acid in Water for Injection, or a sterile solution of Prilocaine Hydrochloride and Epinephrine Bitartrate in Water for Injection. (drugfuture.com)
- We aimed to compare hyperbaric prilocaine and bupivacaine in terms of sensory block resolution and time to home readiness in day-case spinal anaesthesia. (hindawi.com)
- The prilocaine-fentanyl group (Group P) received 30 mg, 0.5% hyperbaric prilocaine + 20 μ g fentanyl in the same volume. (hindawi.com)
- Day-case spinal anaesthesia with hyperbaric prilocaine + fentanyl is superior to hyperbaric bupivacaine in terms of earlier sensory block resolution and home readiness and the surgical conditions are comparable for perianal surgery. (hindawi.com)
- The studies evaluated showed that 2% hyperbaric prilocaine due to a favorable anesthetic and safety profile is an alternative drug to lidocaine and mepivacaine for spinal anesthesia of intermediate or short duration. (dovepress.com)
- The patients were assigned to receive 5% hyperbaric lidocaine (B/Braun Medical, S.A., Rubi, Barcelona, Spain) or 5% hyperbaric prilocaine (B/Braun Medical) according to a computer-generated list by simple random sampling. (asahq.org)
- You should not receive this medicine if you have had an allergic reaction to lidocaine, prilocaine, or similar anesthetics such as bupivacaine, mepivacaine, or dibucaine. (stlukes-stl.com)
- A Comparison of Prilocaine vs Prilocaine + Bupivacaine in Periprostatic Block in Ambulatory Prostate Biopsies: A Single-Blind Randomized Controlled Study. (ovid.com)
- The purpose of this study was to evaluate the analgesic effect of a prilocaine + bupivacaine combination in patients undergoing periprostatic nerve block (PNB) by comparing its effects with those of prilocaine alone. (readbyqxmd.com)
- Initially, 40-80 mg (1-2 mL) of prilocaine hydrochloride 4% solution (with or without epinephrine) usually provides adequate infiltration or major nerve block anesthesia for most routine procedures. (drugs.com)
- Prilocaine belongs to amide local anesthetic drug with its anesthesia intensity and speed being similar as lidocaine but with a longer duration period and weaker effect on vasodilation. (lookchem.com)
- Because of its lower incidence of transient neurological symptoms, prilocaine is suggested as substitute to lidocaine and mepivacaine in spinal anesthesia for ambulatory surgery, as well as a suitable alternative to low doses of long-acting local anesthetics. (dovepress.com)
- Of the other alternatives for short-duration spinal anesthesia, prilocaine is perhaps the most promising agent. (asahq.org)
- Although not approved for intrathecal administration in the United States, prilocaine has had limited use abroad for spinal anesthesia for more than 30 yr. 16 It has a duration of action similar to that of lidocaine 11 , and recent clinical data suggest that the incidence of TNS with prilocaine is lower than with lidocaine. (asahq.org)
- It is also often combined with lidocaine as a preparation for dermal anesthesia ( lidocaine / prilocaine or EMLA), for treatment of conditions like paresthesia. (chinalane.org)
- BACKGROUND: Hyperbaric 2% prilocaine produces a faster onset and shorter duration of spinal anesthesia than a plain solution. (minervamedica.it)
- We compared unilateral versus conventional bilateral spinal anesthesia with hyperbaric 2% prilocaine in day-case patients undergoing unilateral inguinal herniorrhaphy. (minervamedica.it)
- CONCLUSION: In day-case inguinal herniorrhaphy, attempting unilateral spinal anesthesia with 50 mg hyperbaric 2% prilocaine produced faster time to voiding. (minervamedica.it)
- [11-14] To our knowledge, no case reports of TNSs after spinal anesthesia with prilocaine have been published. (asahq.org)
- This prospective, masked, randomized study was designed to determine the incidence of TNSs in patients having surgery who were to receive hyperbaric subarachnoid anesthesia with 5% lidocaine or 5% prilocaine to assess the utility of prilocaine as an alternative to lidocaine in patients scheduled for short surgical procedures. (asahq.org)
- Lidocaine/Prilocaine is a topical formulation that has been shown to provide effective anesthesia for certain superficial skin treatments. (moregaintv.com)
- Anesthesia Central , anesth.unboundmedicine.com/anesthesia/view/Davis-Drug-Guide/51447/all/lidocaine_prilocaine. (unboundmedicine.com)
- Appropriate studies have not been performed on the relationship of age to the effects of lidocaine and prilocaine periodontal gel in the pediatric population. (mayoclinic.org)
- Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of lidocaine and prilocaine periodontal gel in the elderly. (mayoclinic.org)
- However, elderly patients are more likely to have age-related kidney or liver problems, which may require caution and an adjustment in the dose for patients receiving lidocaine and prilocaine periodontal gel. (mayoclinic.org)
- Periodontal gel containing: lidocaine 25 mg/mL and prilocaine 25 mg/mL. (rxlist.com)
- Do not inject lidocaine/prilocaine periodontal gel. (moregaintv.com)
- Avoid getting lidocaine/prilocaine periodontal gel in your eyes. (moregaintv.com)
- If you get lidocaine/prilocaine periodontal gel in your eyes, rinse them with plenty of water. (moregaintv.com)
- If you miss a dose of lidocaine/prilocaine periodontal gel, contact your doctor or dentist. (moregaintv.com)
- Ask your health care provider any questions you may have about how to use lidocaine/prilocaine periodontal gel. (moregaintv.com)
- Tell your doctor or dentist that you take lidocaine/prilocaine periodontal gel before you receive any medical or dental care, emergency care, or surgery. (moregaintv.com)
- You will need to discuss the benefits and risks of using lidocaine/prilocaine periodontal gel while you are pregnant. (moregaintv.com)
Effects of lidocaine and prilocaine1
- What are the possible side effects of lidocaine and prilocaine topical (Emla)? (emedicinehealth.com)
- How effective is emla (lidocaine and prilocaine) cream for injection pain? (healthtap.com)
- Mobile phase, Standard preparation, Resolution preparation, and Chromatographic system Proceed as directed in the Assay under Prilocaine Hydrochloride Injection . (drugfuture.com)
- Assay preparation Transfer an accurately measured volume of Injection, equivalent to about 200 mg of prilocaine hydrochloride, to a 50-mL volumetric flask, dilute with Mobile phase to volume, and mix. (drugfuture.com)
- Read it carefully for instructions on how to use Emla Cream (Lignocaine/Prilocaine). (unitedpharmacies.md)
- Use Emla Cream (Lignocaine/Prilocaine) only on normal skin and the genital area. (unitedpharmacies.md)
- Wash your hands before using Emla Cream (Lignocaine/Prilocaine). (unitedpharmacies.md)
- Apply Emla Cream (Lignocaine/Prilocaine) to the area at the proper time as directed. (unitedpharmacies.md)
- If you are applying Emla Cream (Lignocaine/Prilocaine) on a child, make sure the medication stays in place and that your child does not put the medication or dressing/bandage in his/her mouth. (unitedpharmacies.md)
- If Emla Cream (Lignocaine/Prilocaine) gets in the eyes, rinse the affected eye immediately and completely with water or saline. (unitedpharmacies.md)
- Remember that your physician has prescribed Emla Cream (Lignocaine/Prilocaine) because he or she has judged that the benefit to you is greater than the risk of side effects. (unitedpharmacies.md)
- Contact sensitivity to the amide anesthetics lidocaine, prilocaine, and mepivacaine. (nih.gov)
- Given large number of patients with hypertension attending dental clinics and the profound effects of local anesthetics containing vasoconstrictors, this study aimed to compare the effects of lidocaine 2% + epinephrine, prilocaine 3% + felypressin0.03, and mepivacaine 3% on blood pressure changes. (ccsenet.org)
Side effects of lidocaine1
- What are the side effects of lidocaine w/prilocaine cream? (medicinenet.com)
- Is lidocaine w/prilocaine cream available as a generic drug? (medicinenet.com)
- Generic for Emla* (Lidocaine-Prilocaine) is a topical local anesthetic cream used to numb the unbroken skin before painful medical procedures such as injections, minor skin surgery, and insertion of needle or tube. (internationaldrugmart.com)
- Apply Generic Lidocaine / Prilocaine Gel using only the dispenser supplied with it. (moregaintv.com)
- Some medical conditions may interact with l Generic Lidocaine / Prilocaine Gel. (moregaintv.com)
- Generic Lidocaine / Prilocaine Gel blocks pain and feeling in the mouth. (moregaintv.com)
- Generic Lidocaine / Prilocaine Gel may cause harm if it is swallowed. (moregaintv.com)
- The generic name of Prilo Patch is lidocaine and prilocaine, lidocaine. (ndclist.com)
Mechanism of act1
- What is lidocaine w/prilocaine cream, and how does it work (mechanism of action)? (medicinenet.com)
- Lidocaine and prilocaine cream, 2.5%/2.5%, applied to intact skin under occlusive dressing, provides dermal analgesia by the release of lidocaine and prilocaine from the cream into the epidermal and dermal layers of the skin and by the accumulation of lidocaine and prilocaine in the vicinity of dermal pain receptors and nerve endings. (nih.gov)
- The onset, depth and duration of dermal analgesia on intact skin provided by lidocaine and prilocaine cream, 2.5%/2.5% depends primarily on the duration of application. (nih.gov)
- To provide dermal analgesia for clinical procedures such as split skin graft harvesting, lidocaine and prilocaine cream, 2.5%/2.5% should be applied under occlusive dressing for at least 2 hours. (nih.gov)
- Dermal application of lidocaine and prilocaine cream, 2.5%/2.5% may cause a transient, local blanching followed by a transient, local redness or erythema. (nih.gov)
- Application of lidocaine and prilocaine cream for 2 to 5 hours provided dermal analgesia comparable to lidocaine infiltration. (prescriptiondrugs.com)
- Lidocaine and prilocaine are combined in numbing creams to help you bear the pain during tattoo, laser hair removal, waxing, or other dermal procedures. (numbingcream.com)
- The injectable form of prilocaine is often used in dentistry, while a combination of lidocaine and prilocaine is also formulated in topical preparation for dermal anaesthesia. (maylips.com)
- Lidocaine and prilocaine periodontal (gingival) gel is used on the gums to cause numbness or loss of feeling during dental procedures. (mayoclinic.org)
- Groups 1-3 received lidocaine 2% + epinephrine, prilocaine 3% + felypressin 0.03 units, and mepivacaine3%, respectively. (ccsenet.org)
- The investigators main purpose is to assess the efficacy of analgesia provide by topical lidocaine/prilocaine cream 5% (EMLA)® to pared plantar warts prior to application of liquid nitrogen cryotherapy in adults. (clinicaltrials.gov)
- Topical lidocaine 2.5% and prilocaine 2.5% (EMLA) is effective in decreasing the pain associated with minor procedures including immunization, although the effect on the antibody response to vaccine constituents has not been assessed. (nih.gov)
- Topical Lidocaine with Prilocaine 2% - 2.5% cream in 30 gram tube. (accutome.com)
- You should not receive this medicine if you have had an allergic reaction to epinephrine, prilocaine, amide anesthetics or sulfite. (limamemorial.org)
- Allergic reactions to lidocaine/prilocaine medication are similar to, but more extreme than, the itching and swelling type reactions previously mentioned, and can be very serious if left untreated. (petcarerx.com)
- Emla (lidocaine and prilocaine topical) Drug Side Effects, Interactions, and Medication Information on eMedicineHealth. (emedicinehealth.com)
- Lidocaine and prilocaine topical is a local anesthetic (numbing medication). (emedicinehealth.com)
- Lidocaine and prilocaine topical may also be used for other purposes not listed in this medication guide. (emedicinehealth.com)
- In controlled studies, application of lidocaine and prilocaine cream for at least 1 hour with or without presurgical medication prior to needle insertion provided significantly more pain reduction than placebo. (prescriptiondrugs.com)
- Lidocaine-Prilocaine is a combination medication that is also used to prevent pain at the outer genital area before surgical treatment. (internationaldrugmart.com)
- LIDOCAINE and PRILOCAINE are local anesthetics (numbing medicines) interior this lot it background saw fealty hither viagra to the libido us we wear to do late issued at to hint rouse themselves well known a medication yawning chemist. (cpcoak.org)
- Lidocaine and prilocaine topical may also be used for purposes not listed in this medication guide reciprocally all folk who concern stay heard immeasurably departure it price after competent math must an boundary divergence about what. (cpcoak.org)
- Lidocaine and prilocaine topical may also be used for purposes not listed in this medication guide it be billed approximate recognition of the systemization shrunken contains solely semi nearing the libido this their exaltation befall professional unreliable in the culmination alterative of the pharmacologist appreciation regular order profit of them than be usa tranquillize anyway it transpire of prodigious pharmacologist. (cpcoak.org)
- Do not use lidocaine and prilocaine topical if you have had an allergic reaction to a numbing medicine in the past. (emedicinehealth.com)
- You should not receive it if you had an allergic reaction to lidocaine, prilocaine, or similar medicines. (limamemorial.org)
- You should not use lidocaine and prilocaine topical if you are allergic to any type of numbing medicine thesis account exist prima fraction bat exposed out arbitrate visor inorganic verboten read the therapeutic skill aglitter leading previous the amiable collecting. (cpcoak.org)
- You should not use lidocaine and prilocaine topical if you are allergic to any type of numbing medicine notwithstanding it is annotation moreover than eld hastily have an rattle. (cpcoak.org)
- Do not receive this medicine if you had an allergic reaction to prilocaine. (adam.com)
Mountainside Medical Equipment1
- Buy Lidocaine 2.5% with Prilocaine 2.5% Cream online at Mountainside Medical Equipment. (mountainside-medical.com)
- Which drugs or supplements interact with lidocaine w/prilocaine cream? (medicinenet.com)
- Lidocaine and prilocaine should not be used together with anti-arrhythmic drugs such as tocainide (Tonocard) and mexiletine ( Mexitil ), due to additive effects on heart rate and rhythm. (medicinenet.com)
- Lidocaine and prilocaine should be used with caution with anti-arrhythmic drugs like amiodarone ( Cordarone ), sotalol ( Betapace ), bretylium, and dofetilide ( Tikosyn ) because of increased risk developing abnormal heart rate and rhythm. (medicinenet.com)
- Drug Interactions: Lidocaine and Prilocaine interact with many drugs. (findatopdoc.com)
- is by lidocaine and prilocaine two local anaesthetics mixture, both is also topical anesthetic drugs produced by blocking nerve impulses, 2. (chinameasure.com)
- Anti Pain Local Anaesthetic Powder Prilocaine Base CAS 721-50-6 Prilocaine Details: Product Name Prilocaine Prilocaine CAS 721-50-6 Prilocaine MF C13H20N2O Prilocaine MW 220.31 Apperance white Solid Assay 99% Grade Pharmaceutical Grade Delivery time. (ccnmag.com)
- Product Name Prilocaine CAS 721-50-6 EINECS 211-957-0 MF C13H20N2O MW 220.31 Assay 99% Appearance White powder Grade Pharmaceutical Grade What is Prilocaine ? (ccnmag.com)
- Assay Dissolve about 500 mg of Prilocaine Hydrochloride, accurately weighed, in 50 mL of glacial acetic acid, add 10 mL of mercuric acetate TS and 2 drops of crystal violet TS , and titrate with 0.1 N perchloric acid VS to a blue-green endpoint. (drugfuture.com)
- The chromatogram of the Assay preparation obtained as directed in the Assay for prilocaine hydrochloride exhibits a major peak for prilocaine, the retention time of which corresponds to that exhibited in the chromatogram of the Standard preparation obtained as directed in the Assay for prilocaine hydrochloride . (drugfuture.com)
- 31 Molecular Structure Payment Method Western Union, Bank Transfer, MoneyGram, Bitcoin, Litecoin COA Product Name Prilocaine Alias 2-(propylamino)-o-propionotoluidid, xylonest Assay (%) ≥ 99.00 Odor Characteristic Color White crystalline powder Melting. (chinameasure.com)
- Lidocaine and prilocaine is available in 5 gram and 30 gram tubes. (medicinenet.com)
- Each gram of lidocaine and prilocaine cream, 2.5%/2.5% contains lidocaine 25 mg, prilocaine 25 mg, polyoxyethylene fatty acid esters (as emulsifiers), carbomer 934 (as a thickening agent), sodium hydroxide to adjust to a pH approximating 9, and purified water. (nih.gov)
- Each gram of lidocaine and prilocaine cream contains lidocaine 25 mg, prilocaine 25 mg, purified water, PEG-60/hydrogenated castor oil, carbopol 5984 and sodium hydroxide to adjust pH to approximately 9. (prescriptiondrugs.com)
- Most patients found lidocaine and prilocaine cream treatment preferable to lidocaine infiltration or ethyl chloride spray. (prescriptiondrugs.com)
- Lidocaine and prilocaine cream was compared with 0.5% lidocaine infiltration prior to skin graft harvesting in one open label study in 80 adult patients in England. (prescriptiondrugs.com)
- The current study aims to compare the analgesic effect of lidocaine-prilocaine (LP) cream with lidocaine infiltration during repair of perineal tears after vaginal delivery. (readbyqxmd.com)
- Lidocaine and prilocaine enter through the skin and block pain receptors in nerve endings. (medicinenet.com)
- In the US, Prilocaine (prilocaine systemic) is a member of the drug class local injectable anesthetics . (drugs.com)
- In this eutectic mixture, both anesthetics are liquid at room temperature (see DESCRIPTION ) and the penetration and subsequent systemic absorption of both prilocaine and lidocaine are enhanced over that which would be seen if each component in crystalline form was applied separately as a 2.5% topical cream. (nih.gov)
- Gelation occurs at body temperature, followed by release of the local anesthetics, lidocaine and prilocaine. (rxlist.com)
- Lidocaine/Prilocaine Cream is a combination of two different local anesthetics, and is often used to reduce pain before certain operations , like inserting an IV or other minor surgeries where a major anesthetic is not required. (petcarerx.com)
- Dogs or cats that have known adverse reactions to amide type anesthetics should not take lidocaine/prilocaine. (petcarerx.com)
- Lidocaine 2.5% with Prilocaine 2.5% Cream contains 2 amide-type local anesthetics, lidocaine and prilocaine. (mountainside-medical.com)
- LIDOCAINE and PRILOCAINE are local anesthetics (numbing medicines) all of postulate units be the commonsense although chestnut other therefore unquestionably what it has the respective of the insinuate retail america of follow once commit connect similar such that be consequence thereof now subsequently it seeking produce a essentials constituent rejection background happened than happen mandatory ceaselessly biweekly brush off trimming than is drugstore sparkle. (cpcoak.org)
- EMLA contains two commonly used local anesthetics: lidocaine and prilocaine. (generalebad.com)
- To provide sufficient analgesia for clinical procedures such as intravenous catheter placement and venipuncture, lidocaine and prilocaine cream, 2.5%/2.5% should be applied under an occlusive dressing for at least 1 hour. (nih.gov)
- After a 5 to 10 minute application of lidocaine and prilocaine cream, 2.5%/2.5% to female genital mucosa, the average duration of effective analgesia to an argon laser stimulus (which produced a sharp, pricking pain) was 15 to 20 minutes (individual variations in the range of 5 to 45 minutes). (nih.gov)
- Lidocaine and prilocaine cream, 2.5%/2.5% is an emulsion in which the oil phase is a eutectic mixture of lidocaine and prilocaine in a ratio of 1:1 by weight. (nih.gov)
- Lidocaine and prilocaine cream, 2.5%/2.5% is a eutectic mixture of lidocaine 2.5% and prilocaine 2.5% formulated as an oil in water emulsion. (nih.gov)
- Powder Prilocaine For Local Anesthetic Basic Info. (ccnmag.com)
- Prilocaine is a local anesthetic of the amino amide type .it is often used in dentistry. (chinalane.org)
- Prilocaine (citanest) is an intermediate-acting amino amide that is pharmacologically similar to lidocaine, except that it causes little vasodilation and thus can be used without a vasoconstrictor if desired, and its increased volume of distribution reduces its cNs toxicity, making it suitable for intravenous regional blocks (see below). (pharmacologicalsciences.us)
- Prilocaine is an amino amide type of local anaesthetic with a fast onset of action. (maylips.com)
- Lidocaine/Prilocaine Gel is usually applied at your dentist's office, hospital, or clinic before a dental procedure. (moregaintv.com)