AnatomyDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and Processes
PrilocaineAnesthetics, LocalMepivacaineLidocaineCarticaineAnesthesia, LocalAnesthesia, DentalFelypressinMaxillary NerveDental Pulp TestAnesthesia, ConductionAnesthetics, CombinedMouth RehabilitationMethemoglobinemiaAnesthesia, SpinalAmbulatory Surgical ProceduresTetracaineOintmentsNerve BlockToluidinesNordefrinBupivacainePhlebotomyLacerationsUrinationFemoral NerveCoproporphyria, HereditaryCoproporphyrinsCoproporphyrinogen OxidasePorphyrias, HepaticPorphyriasPorphyrinsPorphyrinogens
Prilocaine
A local anesthetic that is similar pharmacologically to LIDOCAINE. Currently, it is used most often for infiltration anesthesia in dentistry.
Anesthetics, Local
Drugs that block nerve conduction when applied locally to nerve tissue in appropriate concentrations. They act on any part of the nervous system and on every type of nerve fiber. In contact with a nerve trunk, these anesthetics can cause both sensory and motor paralysis in the innervated area. Their action is completely reversible. (From Gilman AG, et. al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed) Nearly all local anesthetics act by reducing the tendency of voltage-dependent sodium channels to activate.
Mepivacaine
A local anesthetic that is chemically related to BUPIVACAINE but pharmacologically related to LIDOCAINE. It is indicated for infiltration, nerve block, and epidural anesthesia. Mepivacaine is effective topically only in large doses and therefore should not be used by this route. (From AMA Drug Evaluations, 1994, p168)
Lidocaine
A local anesthetic and cardiac depressant used as an antiarrhythmia agent. Its actions are more intense and its effects more prolonged than those of PROCAINE but its duration of action is shorter than that of BUPIVACAINE or PRILOCAINE.
Carticaine
A thiophene-containing local anesthetic pharmacologically similar to MEPIVACAINE.
Anesthesia, Local
A blocking of nerve conduction to a specific area by an injection of an anesthetic agent.
Anesthesia, Dental
A range of methods used to reduce pain and anxiety during dental procedures.
Felypressin
A synthetic analog of LYPRESSIN with a PHENYLALANINE substitution at residue 2. Felypressin is a vasoconstrictor with reduced antidiuretic activity.
Maxillary Nerve
The intermediate sensory division of the trigeminal (5th cranial) nerve. The maxillary nerve carries general afferents from the intermediate region of the face including the lower eyelid, nose and upper lip, the maxillary teeth, and parts of the dura.
Dental Pulp Test
Investigations conducted on the physical health of teeth involving use of a tool that transmits hot or cold electric currents on a tooth's surface that can determine problems with that tooth based on reactions to the currents.
Anesthesia, Conduction
Injection of an anesthetic into the nerves to inhibit nerve transmission in a specific part of the body.
Anesthetics, Combined
The use of two or more chemicals simultaneously or sequentially to induce anesthesia. The drugs need not be in the same dosage form.
Mouth Rehabilitation
Process of restoring damaged or decayed teeth using various restorative and non-cosmetic materials so that oral health is improved.
Methemoglobinemia
The presence of methemoglobin in the blood, resulting in cyanosis. A small amount of methemoglobin is present in the blood normally, but injury or toxic agents convert a larger proportion of hemoglobin into methemoglobin, which does not function reversibly as an oxygen carrier. Methemoglobinemia may be due to a defect in the enzyme NADH methemoglobin reductase (an autosomal recessive trait) or to an abnormality in hemoglobin M (an autosomal dominant trait). (Dorland, 27th ed)
Anesthesia, Spinal
Procedure in which an anesthetic is injected directly into the spinal cord.
Ambulatory Surgical Procedures
Surgery performed on an outpatient basis. It may be hospital-based or performed in an office or surgicenter.
Tetracaine
A potent local anesthetic of the ester type used for surface and spinal anesthesia.
Ointments
Semisolid preparations used topically for protective emollient effects or as a vehicle for local administration of medications. Ointment bases are various mixtures of fats, waxes, animal and plant oils and solid and liquid hydrocarbons.
Nerve Block
Interruption of NEURAL CONDUCTION in peripheral nerves or nerve trunks by the injection of a local anesthetic agent (e.g., LIDOCAINE; PHENOL; BOTULINUM TOXINS) to manage or treat pain.
Toluidines
Nordefrin
A norepinephrine derivative used as a vasoconstrictor agent.
Bupivacaine
A widely used local anesthetic agent.
Phlebotomy
The techniques used to draw blood from a vein for diagnostic purposes or for treatment of certain blood disorders such as erythrocytosis, hemochromatosis, polycythemia vera, and porphyria cutanea tarda.
Lacerations
Torn, ragged, mangled wounds.
Urination
Discharge of URINE, liquid waste processed by the KIDNEY, from the body.
Femoral Nerve
A nerve originating in the lumbar spinal cord (usually L2 to L4) and traveling through the lumbar plexus to provide motor innervation to extensors of the thigh and sensory innervation to parts of the thigh, lower leg, and foot, and to the hip and knee joints.
Coproporphyria, Hereditary
An autosomal dominant porphyria that is due to a deficiency of COPROPORPHYRINOGEN OXIDASE in the LIVER, the sixth enzyme in the 8-enzyme biosynthetic pathway of HEME. Clinical features include both neurological symptoms and cutaneous lesions. Patients excrete increased levels of porphyrin precursors, 5-AMINOLEVULINATE and COPROPORPHYRINS.
Coproporphyrins
Porphyrins with four methyl and four propionic acid side chains attached to the pyrrole rings. Elevated levels of Coproporphyrin III in the urine and feces are major findings in patients with HEREDITARY COPROPORPHYRIA.
Coproporphyrinogen Oxidase
An enzyme that catalyzes the oxidative decarboxylation of coproporphyrinogen III to protoporphyrinogen IX by the conversion of two propionate groups to two vinyl groups. It is the sixth enzyme in the 8-enzyme biosynthetic pathway of HEME, and is encoded by CPO gene. Mutations of CPO gene result in HEREDITARY COPROPORPHYRIA.
Porphyrias, Hepatic
A group of metabolic diseases due to deficiency of one of a number of LIVER enzymes in the biosynthetic pathway of HEME. They are characterized by the accumulation and increased excretion of PORPHYRINS or its precursors. Clinical features include neurological symptoms (PORPHYRIA, ACUTE INTERMITTENT), cutaneous lesions due to photosensitivity (PORPHYRIA CUTANEA TARDA), or both (HEREDITARY COPROPORPHYRIA). Hepatic porphyrias can be hereditary or acquired as a result of toxicity to the hepatic tissues.
Porphyrias
A diverse group of metabolic diseases characterized by errors in the biosynthetic pathway of HEME in the LIVER, the BONE MARROW, or both. They are classified by the deficiency of specific enzymes, the tissue site of enzyme defect, or the clinical features that include neurological (acute) or cutaneous (skin lesions). Porphyrias can be hereditary or acquired as a result of toxicity to the hepatic or erythropoietic marrow tissues.
Porphyrins
A group of compounds containing the porphin structure, four pyrrole rings connected by methine bridges in a cyclic configuration to which a variety of side chains are attached. The nature of the side chain is indicated by a prefix, as uroporphyrin, hematoporphyrin, etc. The porphyrins, in combination with iron, form the heme component in biologically significant compounds such as hemoglobin and myoglobin.
Porphyrinogens
Colorless reduced precursors of porphyrins in which the pyrrole rings are linked by methylene (-CH2-) bridges.

Pharmacokinetics of prilocaine after intravenous administration in volunteers: enantioselectivity. (1/141)

BACKGROUND: Prilocaine exists in two stereoisomeric configurations, the enantiomers S(+)- and R(-)-prilocaine. The drug is clinically used as the racemate. This study examined the pharmacokinetics of the enantiomers after intravenous administration of the racemate. METHODS: Ten healthy male volunteers received 200 mg racemic prilocaine as a 10-min intravenous infusion. Blood samples were collected for 8 h after the start of the infusion. Plasma concentrations were measured by stereoselective high-performance liquid chromatography (HPLC). Unbound fractions of the enantiomers in blank blood samples, spiked with racemic prilocaine, were determined using equilibrium dialysis. RESULTS: The unbound fraction of R(-)-prilocaine (mean +/- SD, 70%+/-8%) was smaller (P < 0.05) than that of S(+)-prilocaine (73%+/-5%). The total plasma clearance of R(-)-prilocaine (2.57+/-0.46 l/min) was larger (P < 0.0001) than that of S(+)-prilocaine (1.91+/-0.30 l/min). The steady-state volume of distribution of R(-)-prilocaine (279+/-94 l) did not differ from that of S(+)-prilocaine (291+/-93 l). The terminal half-life of R(-)-prilocaine (87+/-27 min) was shorter (P < 0.05) than that of S(+)-prilocaine (124+/-64 min), as was the mean residence time of R(-)-prilocaine (108+/-30 min) compared with S(+)-prilocaine (155+/-59 min; P < 0.005). CONCLUSIONS: The pharmacokinetics of prilocaine are enantioselective. The difference in clearance is most likely a result of a difference in intrinsic metabolic clearance. The difference in the pharmacokinetics of the enantiomers of prilocaine does not seem to be clinically relevant.  (+info)

Topical anaesthesia of intact skin: liposome-encapsulated tetracaine vs EMLA. (2/141)

In this randomized, double-blind study, we have compared the ability of 5% liposome-encapsulated tetracaine (amethocaine) (LET) vs 5% eutectic mixture of local anaesthetics (EMLA) to produce local anaesthesia of intact skin in 40 healthy volunteers. Volunteers had both preparations applied to their forearms under an occlusive dressing for 1 h. Superficial anaesthesia was measured by a total of nine 1-mm pinpricks on each arm. Deeper anaesthesia was assessed by single insertion of a sterile 22-gauge needle to a depth of 3 mm and pain was reported on a visual analogue scale (VAS). If the volunteer perceived greater than four of the 1-mm pinpricks, the 3-mm insertion was not performed. Results showed that the number of pinpricks perceived was significantly less (P < 0.01) for LET (median 1.0; range 0-9) vs EMLA (1.5; 0-9). In volunteers who had deeper anaesthesia assessed, there was no significant difference (P = 0.065) in VAS scores for LET (mean 1.5 (SD 1.4); n = 34) vs EMLA (2.4 (2.1); n = 28). Overall anaesthetic effect, as ranked by all of the subjects, was significantly better for LET compared with EMLA (P = 0.024). We have demonstrated that when applied in equal volumes, 5% LET produced better superficial local anaesthesia than EMLA.  (+info)

Bone marrow harvesting using EMLA (eutectic mixture of local anaesthetics) cream, local anaesthesia and patient-controlled analgesia with alfentanil. (3/141)

Bone marrow harvesting (BMH) was performed on 40 consecutive allogeneic or autologous donors using EMLA (eutectic mixture of local anaesthetics), local anaesthesia (LA) and patient-controlled analgesia with alfentanil (PCA-A). The effect of alkalinizing the LA solution on reducing pain during LA infiltration in the presence of EMLA was also investigated. EMLA 10 g with occlusive dressing was applied to the harvest sites at least 60 min before BMH. The PCA device was programmed to deliver an intravenous loading dose of 15 microg/kg alfentanil, followed by a background alfentanil infusion of 0.05 microg/kg/min. Demand dose was 4 microg/kg and lockout time was 3 min. Donors were randomized to receive either alkalinized (n = 19) or non-alkalinized (n=21) LA solution (lignocaine 1% with 1:100000 adrenaline). While post-operative nausea and vomiting were the only side-effects, all donors in both groups reported satisfactory pain scores during LA infiltration and satisfactory overall intra-operative comfort scores. They completed BMH using either regimen successfully, found this technique acceptable and would recommend this form of anaesthesia to others. Alkalinizing the LA solution did not significantly improve the pain scores during LA infiltration in the presence of EMLA. In conclusion, BMH can be performed safely using EMLA, LA and PCA-A without major complications.  (+info)

Tetracaine gel vs EMLA cream for percutaneous anaesthesia in children. (4/141)

We have evaluated the anaesthetic effect of tetracaine gel 1 g, applied for 45 min, compared with EMLA cream 2 g, applied for 60 min, in a randomized, double-blind study in 60 children aged 3-15 yr. Venous cannulation was performed 15 min after removal of the EMLA cream (n = 20) and tetracaine gel (n = 20). Cannulation was performed up to 215 min after removal of the tetracaine gel in another 20 patients. Significantly lower pain scores were recorded by the children treated with tetracaine gel compared with EMLA cream (P < 0.02). Forty to 45% of children in the tetracaine groups reported no pain compared with only 10% in the EMLA group. Only minor adverse effects were observed. We conclude that tetracaine gel provided effective, rapid, long-lasting and safe local anaesthesia, and was significantly better than EMLA cream in reducing pain during venous cannulation in children using the recommended application periods for both formulations.  (+info)

A comparison of local anaesthetics for venepuncture. (5/141)

AIM: To compare the effectiveness of EMLA cream and Ametop gel in providing analgesia for venous cannulation. METHODS: Single blind study in 120 children. RESULTS: Both anaesthetic agents produced adequate analgesia. However, Ametop gel was more effective, with a statistically significant difference in the pain scores of the two groups (p < 0.05).  (+info)

Both EMLA and placebo cream reduced pain during extracorporeal piezoelectric shock wave lithotripsy with the Piezolith 2300. (6/141)

BACKGROUND: The objectives were to determine whether a eutectic mixture of local anesthetic (EMLA) or placebo cream reduces pain during extracorporeal piezoelectric shock wave lithotripsy (EPSWL), and to determine which of the components of the application (i.e., the occlusive dressing, the cream, or the local anesthetic) contributes to analgesia. METHODS: A randomized, double blind, crossover study (part 1) was performed in 12 patients who were scheduled for EPSWL procedures on an ambulatory basis who received the first treatment without any intervention and who had verbal pain scores of 70 or more (on a 0-to- 100 scale). For the next two treatments at 2-week intervals, patients were randomly assigned to receive either 10 g EMLA or 10 g placebo cream and then crossed over to receive the other. The cream and occlusive dressing were left in place and immersed in water throughout the procedure. Verbal numeric pain score was assessed at 5 min after receiving the maximal tolerable intensity of shock wave and at the end of the procedure. The study continued (part 2) in 202 ambulatory patients; 125 men and 77 women, American Society of Anesthesiologists physical status I and II, subjected to EPSWL were randomly allocated into five groups who received (1) nothing on the skin (control), (2) plastic occlusive dressing, (3) placebo cream and plastic occlusive dressing, (4) EMLA cream and plastic occlusive dressing, (5) EMLA cream and plastic occlusive dressing for 60 min to achieve cutaneous anesthesia, which was removed before EPSWL. Pain score was evaluated 10 min into the procedure and at the end of the procedure. RESULT: Both parts of the study showed that patients who received either EMLA or placebo cream with dressing throughout the procedure experienced less pain and tolerated higher energy levels compared with the control. Patients who received only pre-EPSWL cutaneous anesthesia of EMLA and who received only the occlusive dressing did not have a reduction in pain score. CONCLUSIONS: EMLA and placebo creams under occlusive dressing reduced pain during EPSWL. The presence of the cream itself as a coupling medium contributed to analgesia. This may be a useful, simple, safe, and economical adjuvant technique to reduce pain during immersion EPSWL.  (+info)

Evaluation of prilocaine for the reduction of pain associated with transmucosal anesthetic administration. (7/141)

This investigation evaluated the use and efficacy of prilocaine HCl (4% plain Citanest) for minimizing pain associated with the intraoral administration of local anesthesia. Clinical anecdotes support the hypothesis that prilocaine without a vasoconstrictor reduces pain during injection. To determine relative injection discomfort, use of 4% plain prilocaine was compared with use of 2% lidocaine with 1:100,000 epinephrine and 2% mepivacaine with 1:20,000 levonordefrin. Prior to routine endodontic procedures, 150 adult patients received 0.3 to 1.8 mL of local anesthetic via the same gauge needle without the use of a topical local anesthetic. Injection methods included buccal infiltration, labial infiltration, palatal infiltration, and inferior alveolar nerve block. Following each injection, patients were asked to describe the level of discomfort by scoring on a visual analog scale of 1 to 10, where 1 = painless and 10 = severe pain. Analyses via 2-way analysis of variance revealed no interaction between anesthetic and site of injection. However, there were statistically significant differences among the injection sites. Post hoc analysis revealed that prilocaine was associated with significantly less pain perception when compared to mepivacaine and lidocaine. These results suggest that differences in initial pain perception during transmucosal injection may be a function of the local anesthetic use, and prilocaine can produce less discomfort than the others tested.  (+info)

A randomised, double-blind, placebo-controlled, comparative study of topical skin analgesics and the anxiety and discomfort associated with venous cannulation. (8/141)

OBJECTIVES: To compare the effect of topical skin anaesthetic agents on the discomfort and anxiety associated with venous cannulation. DESIGN: Randomised, double-blind, placebo-controlled, within subject, volunteer trial. METHODS: 20 healthy volunteers underwent venous cannulation on three separate occasions having received topical skin application of either 4% amethocaine gel (Ametop), 5% eutectic mixture of lidocaine and prilocaine (EMLA) or E45 cream (placebo). Visual analogue and verbal rating scales were used to assess pain and anxiety associated with the venous cannulation, and anticipated anxiety for future cannulation, under each drug condition. RESULTS: Subjects were aged 22-53 years (mean 32.8 years). The mean visual analogue scores (VAS) for discomfort were found to be significantly lower (p< 0.001) with Ametop (VAS = 18mm) and EMLA (VAS = 29mm) compared with the control (VAS = 38mm). There was a positive correlation (R2 = 72%, p<0.001) between discomfort and the predicted anxiety if cannulation was to be repeated with the same cream. With the placebo a positive correlation (R2 = 19.8%, p = 0.05) was found between the level of anxiety before cannulation and the level of discomfort recorded. CONCLUSIONS: Ametop and EMLA topical anaesthetic agents produce effective skin analgesia for venous cannulation. The use of topical analgesia can reduce perceived anxiety about future cannulation procedures. This has application in the management of anxious patients undergoing intravenous sedation, suggesting that topical analgesia prior to venous cannulation may significantly aid anxiolysis.  (+info)

LIDOCAINE and PRILOCAINE CREAM, 2.5%/2.5%LIDOCAINE and PRILOCAINE CREAM, 2.5%/2.5%
When 60 g of lidocaine and prilocaine cream, 2.5%/2.5% was applied over 400 cm2 for 24 hours, peak blood levels of lidocaine are approximately 1/20 the systemic toxic level. Likewise, the maximum prilocaine level is about 1/36 the toxic level. In a pharmacokinetic study, lidocaine and prilocaine cream, 2.5%/2.5% was applied to penile skin in 20 adult male patients in doses ranging from 0.5 g to 3.3 g for 15 minutes. Plasma concentrations of lidocaine and prilocaine following lidocaine and prilocaine cream, 2.5%/2.5% application in this study were consistently low (2.5-16 ng/mL for lidocaine and 2.5-7 ng/mL for prilocaine). The application of lidocaine and prilocaine cream, 2.5%/2.5% to broken or inflamed skin, or to 2,000 cm2 or more of skin where more of both anesthetics are absorbed, could result in higher plasma levels that could, in susceptible individuals, produce a systemic pharmacologic response.. The absorption of lidocaine and prilocaine cream, 2.5%/2.5% applied to genital mucous ...
https://dailymed.nlm.nih.gov/dailymed/archives/fdaDrugInfo.cfm?archiveid=2842
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Prilocaine - WikipediaPrilocaine - Wikipedia
Prilocaine (/ˈpraɪləˌkeɪn/) is a local anesthetic of the amino amide type first prepared by Claes Tegner and Nils Löfgren. In its injectable form (trade name Citanest), it is often used in dentistry. It is also often combined with lidocaine as a topical preparation for dermal anesthesia (lidocaine/prilocaine or EMLA), for treatment of conditions like paresthesia. As it has low cardiac toxicity, it is commonly used for intravenous regional anaesthesia (IVRA). In some patients, ortho-toluidine, a metabolite of prilocaine, may cause methemoglobinemia, which may be treated with methylene blue. Prilocaine may also be contraindicated in people with sickle cell anemia, anemia, or symptomatic hypoxia. People with pseudocholinesterase deficiency may have difficulty metabolizing this anesthetic. It is given as a combination with the vasoconstrictor epinephrine under the trade name Citanest Forte. It is used as an eutectic mixture with lidocaine, 50% w/w, as lidocaine/prilocaine. The mixture is an ...
https://en.wikipedia.org/wiki/Prilocaine
Efficacy Trial of Eutectic Lidocaine/Prilocaine Cream 5% (EMLA) for Analgesia Prior to Cryotherapy of Verrucae Plantaris - Full...Efficacy Trial of Eutectic Lidocaine/Prilocaine Cream 5% (EMLA) for Analgesia Prior to Cryotherapy of Verrucae Plantaris - Full...
Methodology:. The study is a single-centre, double-blind, randomized, placebo-controlled, parallel-group trial with one visit. The investigators planned to include at least 64 patients in 4 months. Adult patients (at least 21 years old) diagnosed with plantar warts are potential subjects for the study.. Once a potential subject is identified, the field investigator will assess him/her for eligibility to enter the study. Then, the potential subject will be provided with full and adequate verbal and written information about the nature, purpose, possible risks and benefits of the study. If the subject agrees to enroll into the study, a signed informed consent will be obtained from him/her.. All patients are randomly assigned by computer-generated randomization sequence to receive either eutectic lidocaine/prilocaine cream (EMLA)® 5% or placebo 60 mins prior to application of cryotherapy. The plantar warts are pared with shape blade before applying EMLA®or placebo cream. Based on the ...
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Biol Neonate 1995; 68: 334-41. Abstract: EMLA (eutectic mixture of lidocaine and prilocaine) cream is currently not recommended for use in infants < 1 month of age because of the potential risk of methemoglobinemia as a result of the o-toluidine metabolite of prilocaine. We studied bioavailablitiy and changes in methemoglobin levels following topical penile exposure to 1 g of EMLA cream for 1 hour in piglets. Lidocaine, prilocaine, and o-toluidine concentrations were measured simultaneously using a high-performance liquid chromatography method. The systemic bioavailability of EMLA was low: 4.0 +/- (SD) 4.7% for lidocaine (range 0-13.6; n=8) and 7.2 +/- 5.7% for prilocaine (range 0-14.5; n=8). The ratio between exposure to o-toluidine with EMLA versus intravenous administration (i.e. AUC EMLA/ AUC IV; see text) was also low: 4.2 +/- 9.3% (range 0-28.6; n=9). The mean maximum methemaglobin value after intravenous administration was 1.23 +/- 0.64% (range 0.5-3.0; n=12) and after penile application ...
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https://en.wikipedia.org/wiki/Herpes_labialis
Tumescent anesthesiaTumescent anesthesia
Prilocaine is also widely used, although it is not formally approved for tumescent anesthesia in the USA. A combination of ... Kendler, Michael; Simon, Jan C.; Wetzig, Tino (June 2013). "Local anesthesia with lidocaine and prilocaine, using the tumescent ... A double-blind randomized intraindividual study of lidocaine versus prilocaine in tumescent anesthesia for liposuction revealed ... intraindividual comparison study of the efficacy of prilocaine and lidocaine in tumescent local anesthesia". Dermatology (Basel ...
https://en.wikipedia.org/wiki/Tumescent_anesthesia
Frenulectomy of the penisFrenulectomy of the penis
First the physician applies a local anesthetic, such as lidocaine/prilocaine cream on the frenulum and surrounding area. In ...
https://en.wikipedia.org/wiki/Frenulectomy_of_the_penis
AnalgesicAnalgesic
These topical anesthetics contain anesthetic drugs such as lidocaine, tetracaine, benzocaine, and prilocaine in a cream, ...
https://en.wikipedia.org/wiki/Analgesic
Spinal anaesthesiaSpinal anaesthesia
... prilocaine, or cinchocaine may also be used. Commonly opioids are added to improve the block and provide post-operative pain ...
https://en.wikipedia.org/wiki/Spinal_anaesthesia
Intravenous regional anesthesiaIntravenous regional anesthesia
A high dose of local anesthetic, typically lidocaine or prilocaine without adrenaline, is slowly injected as distally as ...
https://en.wikipedia.org/wiki/Intravenous_regional_anesthesia
ProcaineProcaine
Like other local anesthetics (such as mepivacaine, and prilocaine), procaine is a vasodilator, thus is often coadministered ...
https://en.wikipedia.org/wiki/Procaine
ParesthesiaParesthesia
... such as lidocaine or prilocaine. Ketamine has also been successfully used, but is generally not approved by insurance. Careful ...
https://en.wikipedia.org/wiki/Paresthesia
AnestheticAnesthetic
Amide local anesthetics (such as lidocaine, prilocaine, bupivacaine, levobupivacaine, ropivacaine, mepivacaine, dibucaine and ...
https://en.wikipedia.org/wiki/Anesthetic
Crack cocaineCrack cocaine
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MethemoglobinemiaMethemoglobinemia
... prilocaine, and lidocaine), and aniline dyes, metoclopramide, rasburicase, umbellulone, chlorates, bromates, and nitrites. ... or topical anesthetics containing benzocaine or prilocaine. Nitrates used in agricultural fertilizers may leak into the ground ...
https://en.wikipedia.org/wiki/Methemoglobinemia
Eutectic systemEutectic system
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https://en.wikipedia.org/wiki/Eutectic_system
ATC code N01ATC code N01
... combinations N01BB54 Prilocaine, combinations N01BB57 Etidocaine, combinations N01BB58 Articaine, combinations N01BB59 ... combinations N01BB01 Bupivacaine N01BB02 Lidocaine N01BB03 Mepivacaine N01BB04 Prilocaine N01BB05 Butanilicaine N01BB06 ...
https://en.wikipedia.org/wiki/ATC_code_N01
Dercums diseaseDercum's disease
... or lidocaine/prilocaine (25 mg/25 mg) cream (EMLA®) have shown a reduction of pain in a few cases. In the 1980s, treatment with ...
https://en.wikipedia.org/wiki/Dercum's_disease
List of MeSH codes (D02)List of MeSH codes (D02)
... prilocaine MeSH D02.065.199.789 - propanil MeSH D02.065.199.860 - salicylanilides MeSH D02.065.199.860.470 - niclosamide MeSH ...
https://en.wikipedia.org/wiki/List_of_MeSH_codes_(D02)
ArticaineArticaine
... concluded that the incidence of paresthesia from either prilocaine or articaine (the only two 4% drugs in the dental market) ... this study are consistent with the suggestion that it is significantly more likely to do so if either articaine or prilocaine ...
https://en.wikipedia.org/wiki/Articaine
List of drugs: Prb-PrnList of drugs: Prb-Prn
... prilocaine (INN) Prilosec Primacor primaperone (INN) primaquine (INN) Primatene Mist Primaxin primidolol (INN) primidone (INN) ...
https://en.wikipedia.org/wiki/List_of_drugs:_Prb–Prn
MethemoglobinMethemoglobin
... especially prilocaine and benzocaine. Amyl nitrite, chloroquine, dapsone, nitrates, nitrites, nitroglycerin, nitroprusside, ...
https://en.wikipedia.org/wiki/Methemoglobin
CetacaineCetacaine
... one of the interactions that can lead to methemoglobinemia is the interaction with sodium nitrate as well as prilocaine, which ...
https://en.wikipedia.org/wiki/Cetacaine
Prilocaine-Induced Methemoglobinemia -- Wisconsin, 1993Prilocaine-Induced Methemoglobinemia -- Wisconsin, 1993
Editorial Note: Prilocaine is a lidocaine homologue and the only secondary amine local anesthetic that remains in clinical use ... Prilocaine-Induced Methemoglobinemia -- Wisconsin, 1993 Methemoglobinemia is an uncommon disorder in which hemoglobin is not ... The oral surgeon had administered 560 mg prilocaine (5.0 mg per pound {11.0 mg/kg} of body weight) by local injection and 60 mg ... The oral surgeon had administered 480 mg prilocaine (4.6 mg per pound {10.1 mg/kg} of body weight) by local injection and 7.5 ...
https://www.cdc.gov/mmwr/preview/mmwrhtml/00032499.htm
Lidocaine/prilocaine topical User Reviews for Anesthesia - Drugs.comLidocaine/prilocaine topical User Reviews for Anesthesia - Drugs.com
Reviews and ratings for Lidocaine/prilocaine topical when used in the treatment of anesthesia. 27 reviews submitted with a 7.3 ... Emla (lidocaine / prilocaine) I was so so nervous to get a blood test for work but I knew it needed to be done. I used EMLA in ... Emla (lidocaine / prilocaine) I only use Emla to have sex. I use it one hour before I have sex with my wife and I enjoy longer ... Emla (lidocaine / prilocaine) I use it when I have sex. Its amazing. I can last for ages now and long enough for my partner ...
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MedlinePlus - Search Results for: LIDOCAINE OR PRILOCAINE
Your provider may recommend skin patches that contain lidocaine (a numbing medicine). Some are prescribed and some ... some of your pain for a short time. Lidocaine also comes as a cream that can be ...
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Diclofenac-menthol-lidocaine-prilocaine-baclofen cream: uses & side-effects | PatientsLikeMeDiclofenac-menthol-lidocaine-prilocaine-baclofen cream: uses & side-effects | PatientsLikeMe
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Prilocaine - IR and Raman spectra | VibratistPrilocaine - IR and Raman spectra | Vibratist
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Lidocaine/prilocaine (Premature Ejaculation): BNF Code 0704060B0 | OpenPrescribingLidocaine/prilocaine (Premature Ejaculation): BNF Code 0704060B0 | OpenPrescribing
Download CSV: all data on Lidocaine/prilocaine (Premature Ejaculation) or data on Lidocaine/prilocaine (Premature Ejaculation) ... Lidocaine/prilocaine (Premature Ejaculation) (0704060B0). Part of chapter 7 Obstetrics, Gynaecology and Urinary-Tract Disorders ... High-level prescribing trends for Lidocaine/prilocaine (Premature Ejaculation) (BNF code 0704060B0) across all GP practices in ...
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Premature Ejaculation Medication: Selective Serotonin Reuptake Inhibitors, Tricyclic antidepressants, Topical anesthetic agents...Premature Ejaculation Medication: Selective Serotonin Reuptake Inhibitors, Tricyclic antidepressants, Topical anesthetic agents...
Lidocaine and prilocaine are amide-type local anesthetic agents. Both agents stabilize neuronal membranes by inhibiting the ... Lidocaine and prilocaine are applied to intact skin under an occlusive dressing, providing dermal analgesia. The effectiveness ... Berkovitch M, Keresteci AG, Koren G. Efficacy of prilocaine-lidocaine cream in the treatment of premature ejaculation. J Urol. ... Henry R, Morales A. Topical lidocaine-prilocaine spray for the treatment of premature ejaculation: a proof of concept study. ...
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prilocaine - NJCCprilocaine - NJCC
Abstract Methaemoglobinaemia is a rare complication of prilocaine, mainly affecting individuals with predisposing conditions or ...
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EMLA, Oraqix (lidocaine-prilocaine) dosing, indications, interactions, adverse effects, and moreEMLA, Oraqix (lidocaine-prilocaine) dosing, indications, interactions, adverse effects, and more
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LIDOCAINE/PRILOCAINE TOPICAL CREAM - PuraGraft
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IMSEAR at SEARO: Anesthetic potential of lidocaine/prilocaine cream versus placebo before venepuncture
Anesthetic potential of lidocaine/prilocaine cream versus placebo before venepuncture. Authors: Gajbhiye, Varsha P.. Lamture, Y ... Other 30 patient were applied normal saline as placebo and 30 patient with lignocaine and prilocaine cream. In the control ... Hence the result is significant at p ,0.05.Conclusions: The present study shows that prilocaine-lidocaine cream reduces the ... Many studies show reducing pain during venepuncture after application of prilocaine/lignocaine, but there are few studies that ...
https://imsear.searo.who.int/handle/123456789/199943
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Cardiovascular effects of local anesthetic prilocaine with felypressin 3% and licocaine 2% in normotensive patientsCardiovascular effects of local anesthetic prilocaine with felypressin 3% and licocaine 2% in normotensive patients
PEREZ, Flávio Eduardo Guillin et al. Cardiovascular effects of local anesthetic prilocaine with felypressin 3% and licocaine 2 ... and prilocaine clhoridrate 3% (30 mg/mL) with (0.03 U.l/mL) felipressin infiltrative administration in ASAI patients. Twenty ...
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Acute Intermittent Porphyria Differential DiagnosesAcute Intermittent Porphyria Differential Diagnoses
Acute intermittent porphyria (AIP) is one of the porphyrias, a group of diseases involving defects in heme metabolism and that results in excessive secretion of porphyrins and porphyrin precursors. AIP manifests itself by abdomen pain, neuropathies, and constipation, but, unlike most types of porphyria, patients with AIP do not have a rash.
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Nitrate/Nitrite Toxicity: Clinical Assessment - Evaluation | Environmental Medicine | ATSDRNitrate/Nitrite Toxicity: Clinical Assessment - Evaluation | Environmental Medicine | ATSDR
EMLA (Eutectic Mixture of Local Anesthetics) topical anesthetic (lidocaine 2.5% and prilocaine 2.5%) ...
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Flecainide (Oral Route) Before Using - Mayo ClinicFlecainide (Oral Route) Before Using - Mayo Clinic
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.. Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.. ...
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Listing of Drugs Currently Regulated as New Drugs (The New Drugs List) - Canada.caListing of Drugs Currently Regulated as New Drugs (The New Drugs List) - Canada.ca
Lidocaine/Prilocaine. Lidocaine hydrocloride (HCl) / Dextrose 5%. (antiarrhythmic agent). Lidocaine HCl/ Norepinephrine ...
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Treatments, Mechanisms, and Adverse Reactions of Anesthetics and Analgesics - 1st EditionTreatments, Mechanisms, and Adverse Reactions of Anesthetics and Analgesics - 1st Edition
Prilocaine: mechanisms and applications. Sreekantha Babu Jonnalagadda. 17. Sevoflurane: features and use in topical application ...
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EMLA cream and associated names | European Medicines AgencyEMLA cream and associated names | European Medicines Agency
Questions and answers on EMLA cream and associated names (lidocaine 25 mg/g and prilocaine 25 mg/g; cream for topical use) (PDF ... Questions and answers on EMLA cream and associated names (lidocaine 25 mg/g and prilocaine 25 mg/g; cream for topical use) (PDF ... EMLA cream is a topical (skin) cream that contains the active substances lidocaine and prilocaine. It is used as a local ... The CHMP agreed that hypersensitivity (allergy) to lidocaine and/or prilocaine or similar local anaesthetics or to any other ...
https://www.ema.europa.eu/en/medicines/human/referrals/emla-cream-associated-names
Cook Children's Health Library - Lidocaine Transdermal Patch - Drug Database - 673459
Thieme E-Journals - Handchirurgie · Mikrochirurgie · Plastische Chirurgie / AbstractThieme E-Journals - Handchirurgie · Mikrochirurgie · Plastische Chirurgie / Abstract
Cost of beauty; prilocaine induced methemoglobinemia. Turk J Emerg Med 2014; 14: 185-187 DOI: 10.5505/1304.7361.2014.79990. ... Prilocaine - methaemoglobinaemia - local anaesthetic - tumescent solution - carcinogenicity Publication History. Received: 30 ... Prilocaine plasma levels and methemoglobinemia in patients undergoing tumescent liposuction involving less than 2,000 ml. ... Aetiologically, prilocaine-induced methaemoglobinaemia is a rare form of acquired methaemoglobinaemia, which occurs rarely in ...
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Nomination Summary for Local anesthetics & metabolites (N20041)Nomination Summary for Local anesthetics & metabolites (N20041)
Nominated Substances: Bupivacaine, Bupivacaine hydrochloride, Etidocaine, Mepivicaine, Mepivicaine hydrochloride, Prilocaine, ...
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Pediatrix - Uses, Side Effects, Interactions - MedBroadcast.comPediatrix - Uses, Side Effects, Interactions - MedBroadcast.com
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Lidocaine and prilocaineAnesthesiaEmlaLignocaine and prilocaineHydrochlorideAnaesthetic prilocaineMetaboliteTopicalCreamMethaemoglobinaemiaComplicationPrescriptionCompoundMethemoglobinemiaLocalSalinePatientsWorkDataPureCodeSolutionEMLABupivacaineBenzocaineEpinephrineFelypressinAnesthesiaAnestheticMethemoglobinemia has generally restrictedDose of prilocaine0.03Ortho-toluidineOraqixAmideVasoconstrictorDentalAnaesthesiaSystemicInjectableExtractionsConclusionsMedicationToxicityIntravenous
Lidocaine and prilocaine4
  • Liba Lidocaine and prilocaine topical from trusted steroids store. (roidsstore.com)
  • EMLA cream is a topical (skin) cream that contains the active substances lidocaine and prilocaine. (europa.eu)
  • Emla (lidocaine and prilocaine) is a type of local anaesthetic, which is a numbing medication. (medisave.ca)
  • The way in which it works is that the active ingredients lidocaine and prilocaine work together to block the nerve signals in your body, which are associated with pain. (medisave.ca)
Anesthesia6
  • Lidocaine / prilocaine topical has an average rating of 7.3 out of 10 from a total of 22 ratings for the treatment of Anesthesia. (drugs.com)
  • Many studies show reducing pain during venepuncture after application of prilocaine/lignocaine, but there are few studies that has depicted, the depth of anesthesia produced by prilocaine/lignocaine tends to be too superficial for the reducing the pain during venepuncture. (who.int)
  • It is also often combined with lidocaine as a preparation for dermal anesthesia (lidocaine/prilocaine or EMLA), for treatment of conditions like paresthesia. (testosteronerawpowder.com)
  • Anesthesia bucal iontophoresis lidocaine mucoadhesion prilocaine. (usp.br)
  • Topical anesthesia of gingival mucosa by 5% eutectic mixture of lignocaine and prilocaine or by 10% lignocaine spray. (thejcdp.com)
  • The search approach comprised (amniocentesis OR amniocenteses) AND (anesthesia OR "local anesthesia" OR lidocaine OR xylocaine OR EMLA OR "lidocaine-prilocaine" OR lignocaine OR prilocaine OR dalcaine OR xylocitin OR xylesthesin OR xyloneural OR "2-2EtN-2MePhAcN" OR otocaine). (tjoddergisi.org)
Emla8
  • Emla (lidocaine / prilocaine) 'I use it when I have sex. (drugs.com)
  • Emla (lidocaine / prilocaine) 'Needed an IV insertion for a contrast MRI, and insisted that EMLA be used. (drugs.com)
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  • Emla (lidocaine / prilocaine) 'I was so so nervous to get a blood test for work but I knew it needed to be done. (drugs.com)
  • Emla (lidocaine / prilocaine) 'Without Emla cream I don't know how I would have made it through my cancer treatments. (drugs.com)
  • Emla (lidocaine / prilocaine) 'I use Emla with a dermaroller. (drugs.com)
  • The CHMP agreed that hypersensitivity (allergy) to lidocaine and/or prilocaine or similar local anaesthetics or to any other ingredients in EMLA cream should be the only contraindication. (europa.eu)
Lignocaine and prilocaine1
  • Other 30 patient were applied normal saline as placebo and 30 patient with lignocaine and prilocaine cream. (who.int)
Hydrochloride1
  • The combination of lidocaine hydrochloride (LCL) and prilocaine (PCL) is an interesting strategy, since lidocaine begins to act more quickly, but prilocaine has a higher potency. (usp.br)
Anaesthetic prilocaine1
  • In patients treated with the anaesthetic prilocaine, ortho-toluidine was detected in urine as a metabolite. (cdc.gov)
Metabolite2
  • Ortho-toluidine, a metabolite of the anesthetic prilocaine, also can induce this condition (1). (cdc.gov)
  • In some patients, a metabolite of prilocaine may cause the unusual side effect of methemoglobinemia, which may be treated with methylene blue. (testosteronerawpowder.com)
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Cream7
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  • Gajbhiye Varsha P., Lamture Y. R.. Anesthetic potential of lidocaine/prilocaine cream versus placebo before venepuncture. (who.int)
  • Therefore, authors planned a study to assess anesthetic potential of lidocaine /prilocaine cream versus placebo before venepuncture with help of VAS in an adult patient who were drawn blood sample for investigation purposes.Methods: Prospective interventional study. (who.int)
  • 0.05.Conclusions: The present study shows that prilocaine-lidocaine cream reduces the pain of needle puncture in adults and facilitates the procedure of venous blood sampling. (who.int)
  • The most commonly used anaesthetics are compound lidocaine/prilocaine cream and tetracaine spray. (bvsalud.org)
  • METHODS: Patients scheduled for laparoscopic cholecystectomy or cholecystectomy combined with common bile duct exploration under general anaesthesia were randomly assigned to Group C (saline spray), Group L (2 g compound lidocaine/prilocaine cream contains 5 mg of lidocaine and 5 mg prilocaine)), Group T (tetracaine) and Group F (compound lidocaine/prilocaine cream combined with tetracaine). (bvsalud.org)
  • CONCLUSIONS: Compound lidocaine/prilocaine cream combined with tetracaine may be a more effective approach for preventing coughing and stabilising circulation during extubation following general anaesthesia. (bvsalud.org)
Methaemoglobinaemia3
  • Abstract Methaemoglobinaemia is a rare complication of prilocaine, mainly affecting individuals with predisposing conditions or those receiving an unusually high dose. (njcc.nl)
  • Aetiologically, prilocaine-induced methaemoglobinaemia is a rare form of acquired methaemoglobinaemia, which occurs rarely in the first place. (thieme-connect.com)
  • We hope that this report draws the attention of emergency care personnel to the possible diagnosis of prilocaine-induced methaemoglobinaemia after liposuction and encourages more general discussions around the use of prilocaine. (thieme-connect.com)
Complication1
  • The following report highlights a potentially dangerous complication arising after application of prilocaine during liposuction. (thieme-connect.com)
Prescription1
  • By continuing, you agree to pick up Lidocaine-prilocaine at the above Pharmacy (Prescription will not be valid at any other pharmacy). (myrxvalet.com)
Compound3
  • PubChem Compound Summary for CID 4906, Prilocaine. (vibratist.com)
  • https://pubchem.ncbi.nlm.nih.gov/compound/Prilocaine. (vibratist.com)
  • We speculated that the application of compound lidocaine/prilocaine combined with tetracaine spray would better prevent coughing caused by tracheal extubation. (bvsalud.org)
Methemoglobinemia3
  • During March-August 1993, three Wisconsin women treated by the same oral surgeon developed methemoglobinemia after being injected with a prilocaine-based local anesthetic. (cdc.gov)
  • Administration of prilocaine in doses exceeding 400 mg has been associated with methemoglobinemia in adults. (cdc.gov)
  • The findings in this report indicate that doses of prilocaine only slightly exceeding the recommended therapeutic dose have the potential to cause methemoglobinemia. (cdc.gov)
Local4
  • The oral surgeon had administered anesthetic of 560 mg prilocaine (4.4 mg per pound {9.7 mg/kg} of body weight) by local injection and 90 mg methohexital sodium, 10 mg diazepam, and 6 mg dexamethasone sodium phosphate by intravenous infusion. (cdc.gov)
  • The oral surgeon had administered 560 mg prilocaine (5.0 mg per pound {11.0 mg/kg} of body weight) by local injection and 60 mg methohexital sodium, 10 mg diazepam, and 0.025 mg fentanyl intravenously. (cdc.gov)
  • The oral surgeon had administered 480 mg prilocaine (4.6 mg per pound {10.1 mg/kg} of body weight) by local injection and 7.5 mg diazepam, 6 mg dexamethasone sodium phosphate, and 0.025 mg fentanyl intravenously. (cdc.gov)
  • Editorial Note: Prilocaine is a lidocaine homologue and the only secondary amine local anesthetic that remains in clinical use. (cdc.gov)
Saline1
  • 30 patients selected in study group received lignocaine/prilocaine locally, 30min prior to venepuncture which was later covered with occlusive tape, whereas 30 control group patient received normal saline locally as placebo. (who.int)
Patients2
  • The aim of this study was to evaluate the cardiovascular effects of intraoral lidocaine clhoridrate 2% (20 mg/mL) and prilocaine clhoridrate 3% (30 mg/mL) with (0.03 U.l/mL) felipressin infiltrative administration in ASAI patients. (bvsalud.org)
  • Furthermore, ortho-toluidine-haemoglobin adducts have been identified in exposed workers, as well as in patients treated with prilocaine. (cdc.gov)
Work1
  • We work on our toes to formulate the Prilocaine USP/BP/EP according to your industry needs. (mentholcristales.com)
Data1
  • all data on Lidocaine/prilocaine (Premature Ejaculation) or data on Lidocaine/prilocaine (Premature Ejaculation) by Sub-ICB Location . (openprescribing.net)
Pure1
  • We are one of the well-reckoned Prilocaine USP/BP/EP Manufacturers In Kurung Kumey , dedicated to offering you the 100% pure and safe Prilocaine USP/BP/EP . (mentholcristales.com)
Code1
  • High-level prescribing trends for Lidocaine/prilocaine (Premature Ejaculation) (BNF code 0704060B0) across all GP practices in NHS England for the last five years. (openprescribing.net)
Solution1
  • A large volume of an anaesthetic solution containing prilocaine had been injected into the tissue. (thieme-connect.com)
EMLA13
  • From that point on the film skin search into yet Lidocaine and Prilocaine (Emla)- Multum combustible crashing action flick with endless CG Lidocaine and Prilocaine (Emla)- Multum effects, all but erasing the character development. (daewoo-egypt.xyz)
  • Lidocaine and Prilocaine (Emla)- Multum creditsThe end credits roll down the mental problems, rather than up. (daewoo-egypt.xyz)
  • Cage and Lidocaine and Prilocaine (Emla)- Multum do well, Moore seems bored with her character, and Lidocaaine yet again embodies the evil of terrorism Mulrum beyond. (daewoo-egypt.xyz)
  • Lidocaine and Prilocaine (Emla)- Multum in The 'Next' Grand Idea (2007)SoundtracksA Sex tantra Less Conversation(JXL Remix)Written by Billy Strange and Mac Lidocaine and Prilocaine (Emla)- Multum (as Scott Davis)Performed by Elvis PresleyCourtesy of The RCA Records LabelBy Granix (Tbo-filgrastim Injection, for Subcutaneous Use)- Multum with Sony BMG Music EntertainmentUser reviews388ReviewTop reviewA Good Idea from Philip K. (daewoo-egypt.xyz)
  • Grady HarpgradyharpSep 29, Lidocaine and Prilocaine (Emla)- Multum Philip K. Contribute to this pageSuggest an edit or add missing contentTop GapWhat is the Hindi language plot outline for Next (2007). (daewoo-egypt.xyz)
  • It is also often combined with lidocaine as a preparation for dermal anesthesia (lidocaine/prilocaine or EMLA), for treatment of conditions like paresthesia. (biosteroids.com)
  • Prilocaine is a local anesthetic of the amino amide type first prepared by Claes Tegner and Nils Lö Fgren.In its injectable form (trade name Citanest), it is often used in dentistry.It is also often combined with lidocaine as a preparation for dermal anesthesia (lidocaine/prilocaine or EMLA), for treatment of conditions like paresthesia.As it has low cardiac toxicity, it is commonly used for intravenous regional anaesthesia (IVRA). (pharmaapis.com)
  • A Double-Blind, Randomised, Placebo-Controlled Trial of EMLA® Cream (Eutectic Lidocaine/Prilocaine Cream). (annals.edu.sg)
  • To desensitize only the skin and upper subcutaneous layers, eutectic mixture of local anaesthetics (EMLA) cream (lidocaine and prilocaine) (generally used to aid vascular catheterization). (vin.com)
  • The association between prilocaine and methemoglobinemia has generally restricted prilocaine use in infants and children to the eutectic mixture of local anesthetics (EMLA). (nih.gov)
  • Individuals who are currently taking medication that may cause methemoglobinemia such as nitrates derivatives, sulfonamides, dapsone, phenacetin, phenazopyridine, some local anesthetics such as prilocaine, topical anesthetics such as emla cream, benzocaine. (nih.gov)
  • RESULTS: Dermatologists who perceived that licensing was required for INE were significantly more likely to refer patients to INE for hair removal (P = 0.001) and prescribe EMLA cream (lidocaine 2.5% and prilocaine 2.5%) to patients requesting it for electrolysis performed by INE (P = 0.001). (hairfacts.com)
  • Emla is a mixture of two local anaesthetics, lignocaine and prilocaine. (dissectpodcast.com)
Bupivacaine4
  • Within the limitations of this study it is concluded that bupivacaine 0.75% compared to prilocaine 3% showed no statistically significant cardiovascular changes and marked intrinsic vasoconstrictor effects were not observed in this study. (oatext.com)
  • People who are allergic to lidocaine or other amide-type local anaesthetics, eg bupivacaine, prilocaine. (netdoctor.co.uk)
  • LAs contain an aromatic ring (lipophilic) at one end and an ionizable group at the other and an intermediate chain in between, which can be either an ester (tetracaine, procaine, benzocaine) or an amide (lidocaine, bupivacaine, ropivacaine, mepivacaine, prilocaine and their respective mono-isomers). (vin.com)
  • They should not be used by children and adolescents under 18 years of age, or by people who are allergic to local anaesthetics such as bupivacaine, etidocaine, mepivacaine or prilocaine. (netdoctor.co.uk)
Benzocaine2
  • Ester (prilocaine, benzocaine) LAs may cause allergic reactions in some animals and methemoglobinemia in cats. (vin.com)
  • These anesthetic creams and sprays contain a numbing agent, such as benzocaine, lidocaine or prilocaine, which should be applied to the penis 10 to 15 minutes before sex to reduce sensation and subsequently delay ejaculation. (askmen.com)
Epinephrine5
  • 4% Citanest ® Forte DENTAL with Epinephrine 1:200,000 (Citanest Forte), Prilocaine HCl 4% (72 mg/1.8 mL) (40 mg/mL) with Epinephrine 1:200,000 Injection, is a sterile, non-pyrogenic isotonic solution that contains a local anesthetic agent with epinephrine (as bitartrate) and is administered parenterally by injection. (nih.gov)
  • The aim of this study was to compare the effectiveness of 2% lidocaine with epinephrine (1:100,000) and 3% prilocaine with felypressin (0.03 I.U. per ml) and the possibility of using them in the oral surgery of medically compromised patients. (org.sa)
  • There are no practical clinical differences between prilocaine with and without epinephrine when used for inferior alveolar blocks. (drugs.com)
  • For long procedures, or those involving maxillary posterior teeth where soft tissue numbness is not troublesome to the patient, Prilocaine HCl 4% with epinephrine 1:200,000 is recommended. (drugs.com)
  • Active ingredient composition: 5% lidocaine, 5% prilocaine and 1% epinephrine. (crowandbutterfly.com)
Felypressin7
  • General anesthesia was performed, during which 3% prilocaine with 0.03 IU/mL felypressin was administered intraoperatively via infiltration. (nih.gov)
  • Patients treatment group II received prilocaine 3% and felypressin 0.03 I.U. per ml. (org.sa)
  • Prilocaine with felypressin could be a good choice for patients who have contraindication to the use of lidocaine with adrenaline. (org.sa)
  • Felypressin added to prilocaine in a concentration of 0.03 IU/ml. (org.sa)
  • In light of these facts, prilocaine with felypressin could be of value to be used in medically compromised patients because it has less vasodilation, toxicity and fewer hemodynamic effects than lidocaine with adrenaline. (org.sa)
  • Group two received prilocaine with 3% felypressin (0.03 I.U. per ml). (saudija.org)
  • 3% Prilocaine with felypressin is as effective as 4% articaine with adrenaline when used for the extraction of maxillary teeth. (saudija.org)
Anesthesia10
  • Local anesthesia with prilocaine has become a routine part of ambulatory circumcision procedures. (medscape.com)
  • We report the case of a 40-day-old Turkish boy who presented with cyanosis after receiving local anesthesia with prilocaine. (medscape.com)
  • For a variety of surgical epidural block and infiltration anesthesia Prilocaine topical is a local anesthetic (numbing medication).It works by blocking nerve signals in your body.Prilocaine topical is used to numb the skin, or surfaces of the penis or vagina, in preparation for a medical procedure or to lessen the pain of inserting a medical instrument such as a tube or speculum. (pharmaapis.com)
  • Thus, it is objective of this study comparing the effects of ropivacaine and prilocaine in the cardiovascular system when used in simple extractions procedures after the blockade in anesthesia infiltrating terminals jaw. (oatext.com)
  • There were no significant differences in the mean onset time of pulpal anesthesia and extraction between the prilocaine and lidocaine buccal infiltration groups ( p =0.28). (org.sa)
  • However, clinically, the patients in prilocaine group recorded faster onset time of anesthesia and teeth extraction than those in lidocaine group. (org.sa)
  • Prilocaine has a better clinical performance in terms of providing rapid dental anesthesia and earlier teeth extraction than lidocaine but the differences were not significant. (org.sa)
  • Pulse-Oximetric Measurement of Prilocaine-Induced Methemoglobinemia in Regional Anesthesia. (masimo.com)
  • However, there were six patients with failure anesthesia (5 in prilocaine group and 1 in articaine group). (saudija.org)
  • T-test showed that there have been no important variations within the mean onset time of anesthesia for articaine and prilocaine buccal infiltrations ( P = 0.1). (saudija.org)
Anesthetic13
  • Lidocaine 2.5% and Prilocaine 2.5%, a topical anesthetic agent, is an emulsion in which the oil phase is a eutectic mixture of lidocaine and prilocaine in a ratio of 1:1 by weight. (nih.gov)
  • Lidocaine and prilocaine are amide-type local anesthetic agents. (nih.gov)
  • Both lidocaine and prilocaine stabilize neuronal membranes by inhibiting the ionic fluxes required for the initiation and conduction of impulses, thereby effecting local anesthetic action. (nih.gov)
  • Prilocaine stabilizes the neuronal membrane by inhibiting the ionic fluxes required for the initiation and conduction of impulses, thereby effecting local anesthetic action. (nih.gov)
  • As with other local anesthetic agents, the plasma binding of prilocaine may be dependent on drug concentration. (nih.gov)
  • Prilocaine topical is a local anesthetic (numbing medication).It works by blocking nerve signals in your body. (pharmaapis.com)
  • To this end, 14 healthy patients (Class 1 - anesthetic risk rating recommended by the American Society of Anesthesiology) were selected and received anesthetic infiltration of 3.6 mL of 0.75% ropivacaine and 3.6 ml of prilocaine 3% for extraction of third molars jaw. (oatext.com)
  • 1 - 4 Lidocaine and prilocaine are amide local anesthetic agents but prilocaine is less toxic and vasodilator than lidocaine. (org.sa)
  • 13. Hemoglobin adducts of the human bladder carcinogen o-toluidine after treatment with the local anesthetic prilocaine. (nih.gov)
  • The use of lidocaine/ prilocaine anesthetic ointment instead of injectable local lidocaine in transradial catheterization was found to be equally effective. (medscape.com)
  • Prilocaine is a topical anesthetic that causes loss of feeling in the skin and surrounding tissues. (dissectpodcast.com)
  • To compare the anesthetic performances of 3% prilocaine and 4% articaine when used for the extraction of the maxillary teeth. (saudija.org)
  • By applying Person's Chi-square test (x2), there were no significant differences in the number of episodes of the anesthetic success between articaine and prilocaine groups at time intervals ( P = 0.5). (saudija.org)
Methemoglobinemia has generally restricted1
  • Although the association between prilocaine use and methemoglobinemia has generally restricted the use of prilocaine in babies, it is still widely used in ambulatory procedures, especially during circumcision in the neonatal period. (medscape.com)
Dose of prilocaine1
  • Based on the low excretion of other local anesthetics into breastmilk, a single dose of prilocaine injected during breastfeeding, such as for a dental procedure, is unlikely to adversely affect the breastfed infant. (nih.gov)
0.031
  • The aim of this study was to evaluate the cardiovascular effects of intraoral lidocaine clhoridrate 2% (20 mg/mL) and prilocaine clhoridrate 3% (30 mg/mL) with (0.03 U.l/mL) felipressin infiltrative administration in ASAI patients. (bvsalud.org)
Ortho-toluidine2
  • Hydrolysis of prilocaine by amidases yields ortho-toluidine and n-proylalanine. (nih.gov)
  • Furthermore, ortho-toluidine-haemoglobin adducts have been identified in exposed workers, as well as in patients treated with prilocaine. (cdc.gov)
Oraqix2
  • The Institute has been ranked No. Nestled in the serene setting of a beautiful countryside, Pakistan Institute of Engineering and Applied Sciences (PIEAS), Islamabad, is recognized as a Oraqix (Lidocaine and Prilocaine Periodontal Gel)- FDA federal Orqqix university devoted to higher education in specific disciplines of engineering, natural sciences and formal sciences. (tbly.xyz)
  • The aim of the work was to Oraqix (Lidocaine and Prilocaine Periodontal Gel)- FDA the effect of Oraqix (Lidocaine and Prilocaine Periodontal Gel)- FDA BNC dehydration followed by rehydration on its mechanical and physicochemical properties, in the context of Oraqix (Lidocaine and Prilocaine Periodontal Gel)- FDA use of BNC as bio-prostheses in the cardiovascular system. (tbly.xyz)
Amide1
  • This medication contains 2 amide-type local anesthetics, lidocaine and prilocaine. (webmd.com)
Vasoconstrictor2
  • Information derived from diverse formulations, concentrations and usages reveals that prilocaine is completely absorbed following parenteral administration, its rate of absorption depending, for example, upon such factors as the site of administration and the presence or absence of a vasoconstrictor agent. (nih.gov)
  • 5 So, prilocaine can be a good choice for patients for whom vasoconstrictor is contraindicated. (org.sa)
Dental3
  • Limited information is currently available on methemoglobinemia caused by the administration of prilocaine in children undergoing dental procedures in Japan. (nih.gov)
  • Methemoglobin Levels in Generally Anesthetized Pediatric Dental Patients Receiving Prilocaine versus Lidocaine. (masimo.com)
  • Recommendations would be given to the dental practitioners to use prilocaine more frequently than articaine because of its low toxicity. (saudija.org)
Anaesthesia1
  • Pulse Oximeter Methemoglobin Measurements in Patients with Tumescent Anaesthesia and Prilocaine. (masimo.com)
Systemic1
  • Factors such as acidosis and the use of CNS stimulants and depressants affect the CNS levels of prilocaine required to produce overt systemic effects. (nih.gov)
Injectable1
  • Only two (lidocaine and prilocaine) are available as both topical and injectable agents in dentistry. (cdeworld.com)
Extractions1
  • To investigate the potency and speed of action of 2% lidocaine and 3% prilocaine for upper teeth extractions. (org.sa)
Conclusions1
  • An overview of Genetic Toxicology Bacterial Mutagenicity study conclusions related to Prilocaine (721-50-6). (nih.gov)
Medication1
  • Prilocaine topical may also be used for other purposes not listed in this medication guide. (pharmaapis.com)
Toxicity1
  • Genetic Toxicity Evaluation of Prilocaine in Salmonella/E.coli Mutagenicity Test or Ames Test. (nih.gov)
Intravenous1
  • [ 6 ] We report a patient with prilocaine-induced acquired methemoglobinemia and discuss the use of intravenous methylene blue treatment. (medscape.com)
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