Prilocaine
Anesthetics, Local
Drugs that block nerve conduction when applied locally to nerve tissue in appropriate concentrations. They act on any part of the nervous system and on every type of nerve fiber. In contact with a nerve trunk, these anesthetics can cause both sensory and motor paralysis in the innervated area. Their action is completely reversible. (From Gilman AG, et. al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed) Nearly all local anesthetics act by reducing the tendency of voltage-dependent sodium channels to activate.
Mepivacaine
A local anesthetic that is chemically related to BUPIVACAINE but pharmacologically related to LIDOCAINE. It is indicated for infiltration, nerve block, and epidural anesthesia. Mepivacaine is effective topically only in large doses and therefore should not be used by this route. (From AMA Drug Evaluations, 1994, p168)
Lidocaine
Anesthesia, Local
Felypressin
Maxillary Nerve
Dental Pulp Test
Anesthesia, Conduction
Anesthetics, Combined
Mouth Rehabilitation
Methemoglobinemia
The presence of methemoglobin in the blood, resulting in cyanosis. A small amount of methemoglobin is present in the blood normally, but injury or toxic agents convert a larger proportion of hemoglobin into methemoglobin, which does not function reversibly as an oxygen carrier. Methemoglobinemia may be due to a defect in the enzyme NADH methemoglobin reductase (an autosomal recessive trait) or to an abnormality in hemoglobin M (an autosomal dominant trait). (Dorland, 27th ed)
Ambulatory Surgical Procedures
Ointments
Nerve Block
Phlebotomy
Femoral Nerve
Coproporphyria, Hereditary
An autosomal dominant porphyria that is due to a deficiency of COPROPORPHYRINOGEN OXIDASE in the LIVER, the sixth enzyme in the 8-enzyme biosynthetic pathway of HEME. Clinical features include both neurological symptoms and cutaneous lesions. Patients excrete increased levels of porphyrin precursors, 5-AMINOLEVULINATE and COPROPORPHYRINS.
Coproporphyrins
Coproporphyrinogen Oxidase
An enzyme that catalyzes the oxidative decarboxylation of coproporphyrinogen III to protoporphyrinogen IX by the conversion of two propionate groups to two vinyl groups. It is the sixth enzyme in the 8-enzyme biosynthetic pathway of HEME, and is encoded by CPO gene. Mutations of CPO gene result in HEREDITARY COPROPORPHYRIA.
Porphyrias, Hepatic
A group of metabolic diseases due to deficiency of one of a number of LIVER enzymes in the biosynthetic pathway of HEME. They are characterized by the accumulation and increased excretion of PORPHYRINS or its precursors. Clinical features include neurological symptoms (PORPHYRIA, ACUTE INTERMITTENT), cutaneous lesions due to photosensitivity (PORPHYRIA CUTANEA TARDA), or both (HEREDITARY COPROPORPHYRIA). Hepatic porphyrias can be hereditary or acquired as a result of toxicity to the hepatic tissues.
Porphyrias
A diverse group of metabolic diseases characterized by errors in the biosynthetic pathway of HEME in the LIVER, the BONE MARROW, or both. They are classified by the deficiency of specific enzymes, the tissue site of enzyme defect, or the clinical features that include neurological (acute) or cutaneous (skin lesions). Porphyrias can be hereditary or acquired as a result of toxicity to the hepatic or erythropoietic marrow tissues.
Porphyrins
A group of compounds containing the porphin structure, four pyrrole rings connected by methine bridges in a cyclic configuration to which a variety of side chains are attached. The nature of the side chain is indicated by a prefix, as uroporphyrin, hematoporphyrin, etc. The porphyrins, in combination with iron, form the heme component in biologically significant compounds such as hemoglobin and myoglobin.
Pharmacokinetics of prilocaine after intravenous administration in volunteers: enantioselectivity. (1/141)
BACKGROUND: Prilocaine exists in two stereoisomeric configurations, the enantiomers S(+)- and R(-)-prilocaine. The drug is clinically used as the racemate. This study examined the pharmacokinetics of the enantiomers after intravenous administration of the racemate. METHODS: Ten healthy male volunteers received 200 mg racemic prilocaine as a 10-min intravenous infusion. Blood samples were collected for 8 h after the start of the infusion. Plasma concentrations were measured by stereoselective high-performance liquid chromatography (HPLC). Unbound fractions of the enantiomers in blank blood samples, spiked with racemic prilocaine, were determined using equilibrium dialysis. RESULTS: The unbound fraction of R(-)-prilocaine (mean +/- SD, 70%+/-8%) was smaller (P < 0.05) than that of S(+)-prilocaine (73%+/-5%). The total plasma clearance of R(-)-prilocaine (2.57+/-0.46 l/min) was larger (P < 0.0001) than that of S(+)-prilocaine (1.91+/-0.30 l/min). The steady-state volume of distribution of R(-)-prilocaine (279+/-94 l) did not differ from that of S(+)-prilocaine (291+/-93 l). The terminal half-life of R(-)-prilocaine (87+/-27 min) was shorter (P < 0.05) than that of S(+)-prilocaine (124+/-64 min), as was the mean residence time of R(-)-prilocaine (108+/-30 min) compared with S(+)-prilocaine (155+/-59 min; P < 0.005). CONCLUSIONS: The pharmacokinetics of prilocaine are enantioselective. The difference in clearance is most likely a result of a difference in intrinsic metabolic clearance. The difference in the pharmacokinetics of the enantiomers of prilocaine does not seem to be clinically relevant. (+info)Topical anaesthesia of intact skin: liposome-encapsulated tetracaine vs EMLA. (2/141)
In this randomized, double-blind study, we have compared the ability of 5% liposome-encapsulated tetracaine (amethocaine) (LET) vs 5% eutectic mixture of local anaesthetics (EMLA) to produce local anaesthesia of intact skin in 40 healthy volunteers. Volunteers had both preparations applied to their forearms under an occlusive dressing for 1 h. Superficial anaesthesia was measured by a total of nine 1-mm pinpricks on each arm. Deeper anaesthesia was assessed by single insertion of a sterile 22-gauge needle to a depth of 3 mm and pain was reported on a visual analogue scale (VAS). If the volunteer perceived greater than four of the 1-mm pinpricks, the 3-mm insertion was not performed. Results showed that the number of pinpricks perceived was significantly less (P < 0.01) for LET (median 1.0; range 0-9) vs EMLA (1.5; 0-9). In volunteers who had deeper anaesthesia assessed, there was no significant difference (P = 0.065) in VAS scores for LET (mean 1.5 (SD 1.4); n = 34) vs EMLA (2.4 (2.1); n = 28). Overall anaesthetic effect, as ranked by all of the subjects, was significantly better for LET compared with EMLA (P = 0.024). We have demonstrated that when applied in equal volumes, 5% LET produced better superficial local anaesthesia than EMLA. (+info)Bone marrow harvesting using EMLA (eutectic mixture of local anaesthetics) cream, local anaesthesia and patient-controlled analgesia with alfentanil. (3/141)
Bone marrow harvesting (BMH) was performed on 40 consecutive allogeneic or autologous donors using EMLA (eutectic mixture of local anaesthetics), local anaesthesia (LA) and patient-controlled analgesia with alfentanil (PCA-A). The effect of alkalinizing the LA solution on reducing pain during LA infiltration in the presence of EMLA was also investigated. EMLA 10 g with occlusive dressing was applied to the harvest sites at least 60 min before BMH. The PCA device was programmed to deliver an intravenous loading dose of 15 microg/kg alfentanil, followed by a background alfentanil infusion of 0.05 microg/kg/min. Demand dose was 4 microg/kg and lockout time was 3 min. Donors were randomized to receive either alkalinized (n = 19) or non-alkalinized (n=21) LA solution (lignocaine 1% with 1:100000 adrenaline). While post-operative nausea and vomiting were the only side-effects, all donors in both groups reported satisfactory pain scores during LA infiltration and satisfactory overall intra-operative comfort scores. They completed BMH using either regimen successfully, found this technique acceptable and would recommend this form of anaesthesia to others. Alkalinizing the LA solution did not significantly improve the pain scores during LA infiltration in the presence of EMLA. In conclusion, BMH can be performed safely using EMLA, LA and PCA-A without major complications. (+info)Tetracaine gel vs EMLA cream for percutaneous anaesthesia in children. (4/141)
We have evaluated the anaesthetic effect of tetracaine gel 1 g, applied for 45 min, compared with EMLA cream 2 g, applied for 60 min, in a randomized, double-blind study in 60 children aged 3-15 yr. Venous cannulation was performed 15 min after removal of the EMLA cream (n = 20) and tetracaine gel (n = 20). Cannulation was performed up to 215 min after removal of the tetracaine gel in another 20 patients. Significantly lower pain scores were recorded by the children treated with tetracaine gel compared with EMLA cream (P < 0.02). Forty to 45% of children in the tetracaine groups reported no pain compared with only 10% in the EMLA group. Only minor adverse effects were observed. We conclude that tetracaine gel provided effective, rapid, long-lasting and safe local anaesthesia, and was significantly better than EMLA cream in reducing pain during venous cannulation in children using the recommended application periods for both formulations. (+info)A comparison of local anaesthetics for venepuncture. (5/141)
AIM: To compare the effectiveness of EMLA cream and Ametop gel in providing analgesia for venous cannulation. METHODS: Single blind study in 120 children. RESULTS: Both anaesthetic agents produced adequate analgesia. However, Ametop gel was more effective, with a statistically significant difference in the pain scores of the two groups (p < 0.05). (+info)Both EMLA and placebo cream reduced pain during extracorporeal piezoelectric shock wave lithotripsy with the Piezolith 2300. (6/141)
BACKGROUND: The objectives were to determine whether a eutectic mixture of local anesthetic (EMLA) or placebo cream reduces pain during extracorporeal piezoelectric shock wave lithotripsy (EPSWL), and to determine which of the components of the application (i.e., the occlusive dressing, the cream, or the local anesthetic) contributes to analgesia. METHODS: A randomized, double blind, crossover study (part 1) was performed in 12 patients who were scheduled for EPSWL procedures on an ambulatory basis who received the first treatment without any intervention and who had verbal pain scores of 70 or more (on a 0-to- 100 scale). For the next two treatments at 2-week intervals, patients were randomly assigned to receive either 10 g EMLA or 10 g placebo cream and then crossed over to receive the other. The cream and occlusive dressing were left in place and immersed in water throughout the procedure. Verbal numeric pain score was assessed at 5 min after receiving the maximal tolerable intensity of shock wave and at the end of the procedure. The study continued (part 2) in 202 ambulatory patients; 125 men and 77 women, American Society of Anesthesiologists physical status I and II, subjected to EPSWL were randomly allocated into five groups who received (1) nothing on the skin (control), (2) plastic occlusive dressing, (3) placebo cream and plastic occlusive dressing, (4) EMLA cream and plastic occlusive dressing, (5) EMLA cream and plastic occlusive dressing for 60 min to achieve cutaneous anesthesia, which was removed before EPSWL. Pain score was evaluated 10 min into the procedure and at the end of the procedure. RESULT: Both parts of the study showed that patients who received either EMLA or placebo cream with dressing throughout the procedure experienced less pain and tolerated higher energy levels compared with the control. Patients who received only pre-EPSWL cutaneous anesthesia of EMLA and who received only the occlusive dressing did not have a reduction in pain score. CONCLUSIONS: EMLA and placebo creams under occlusive dressing reduced pain during EPSWL. The presence of the cream itself as a coupling medium contributed to analgesia. This may be a useful, simple, safe, and economical adjuvant technique to reduce pain during immersion EPSWL. (+info)Evaluation of prilocaine for the reduction of pain associated with transmucosal anesthetic administration. (7/141)
This investigation evaluated the use and efficacy of prilocaine HCl (4% plain Citanest) for minimizing pain associated with the intraoral administration of local anesthesia. Clinical anecdotes support the hypothesis that prilocaine without a vasoconstrictor reduces pain during injection. To determine relative injection discomfort, use of 4% plain prilocaine was compared with use of 2% lidocaine with 1:100,000 epinephrine and 2% mepivacaine with 1:20,000 levonordefrin. Prior to routine endodontic procedures, 150 adult patients received 0.3 to 1.8 mL of local anesthetic via the same gauge needle without the use of a topical local anesthetic. Injection methods included buccal infiltration, labial infiltration, palatal infiltration, and inferior alveolar nerve block. Following each injection, patients were asked to describe the level of discomfort by scoring on a visual analog scale of 1 to 10, where 1 = painless and 10 = severe pain. Analyses via 2-way analysis of variance revealed no interaction between anesthetic and site of injection. However, there were statistically significant differences among the injection sites. Post hoc analysis revealed that prilocaine was associated with significantly less pain perception when compared to mepivacaine and lidocaine. These results suggest that differences in initial pain perception during transmucosal injection may be a function of the local anesthetic use, and prilocaine can produce less discomfort than the others tested. (+info)A randomised, double-blind, placebo-controlled, comparative study of topical skin analgesics and the anxiety and discomfort associated with venous cannulation. (8/141)
OBJECTIVES: To compare the effect of topical skin anaesthetic agents on the discomfort and anxiety associated with venous cannulation. DESIGN: Randomised, double-blind, placebo-controlled, within subject, volunteer trial. METHODS: 20 healthy volunteers underwent venous cannulation on three separate occasions having received topical skin application of either 4% amethocaine gel (Ametop), 5% eutectic mixture of lidocaine and prilocaine (EMLA) or E45 cream (placebo). Visual analogue and verbal rating scales were used to assess pain and anxiety associated with the venous cannulation, and anticipated anxiety for future cannulation, under each drug condition. RESULTS: Subjects were aged 22-53 years (mean 32.8 years). The mean visual analogue scores (VAS) for discomfort were found to be significantly lower (p< 0.001) with Ametop (VAS = 18mm) and EMLA (VAS = 29mm) compared with the control (VAS = 38mm). There was a positive correlation (R2 = 72%, p<0.001) between discomfort and the predicted anxiety if cannulation was to be repeated with the same cream. With the placebo a positive correlation (R2 = 19.8%, p = 0.05) was found between the level of anxiety before cannulation and the level of discomfort recorded. CONCLUSIONS: Ametop and EMLA topical anaesthetic agents produce effective skin analgesia for venous cannulation. The use of topical analgesia can reduce perceived anxiety about future cannulation procedures. This has application in the management of anxious patients undergoing intravenous sedation, suggesting that topical analgesia prior to venous cannulation may significantly aid anxiolysis. (+info)
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Prilocaine
... completed the synthesis of prilocaine (5). Lidocaine/prilocaine "Prilocaine". Merriam-Webster Dictionary. Retrieved 2016-01-21 ... a metabolite of prilocaine, may cause methemoglobinemia, which may be treated with methylene blue. Prilocaine may also be ... 沈文晖, 杨忠鑫, 葛小强, 张宇生, 邹玉龙, 张强, 杨继斌, 蔡中文, CN 105439887 (2016 to 重庆康乐制药有限公司). "Prilocaine". Drug Information Portal. U.S. National ... Prilocaine (/ˈpraɪləˌkeɪn/) is a local anesthetic of the amino amide type first prepared by
O-Toluidine
Large prilocaine doses can cause methemoglobinemia due to oxidation of hemoglobin by o-toluidine. o-Toluidine is absorbed ... Prilocaine, an amino amide-type local anesthetic, yields o-toluidine when metabolized by carboxylesterase enzymes. ... "Prilocaine-Induced Methemoglobinemia". Case Rep. Acute Med. 3 (2): 25-28. doi:10.1159/000508403.{{cite journal}}: CS1 maint: ... "Prilocaine- and Lidocaine-Induced Methemoglobinemia Is Caused by Human Carboxylesterase-, CYP2E1-, and CYP3A4-Mediated ...
Lidocaine
"Lidocaine/prilocaine spray for premature ejaculation". Drug and Therapeutics Bulletin. 55 (4): 45-48. April 2017. doi:10.1136/ ... There is some weak evidence to suggest that the use of alternative anesthetic medications such as prilocaine, procaine, ... "Revision Bulletin: Lidocaine and Prilocaine Cream-Revision to Related Compounds Test". The United States Pharmacopeial ... Dimethocaine (has some DRI activity) Lidocaine/prilocaine Procaine Mexiletine "Lidocaine". Merriam-Webster Dictionary. " ...
Methylene blue
Adams V, Marley J, McCarroll C (November 2007). "Prilocaine induced methaemoglobinaemia in a medically compromised patient. Was ...
Dental anesthesia
Prilocaine is especially suitable for a patient who wishes to avoid adrenaline or may have a latex/preservative allergy. The ... lignocaine and prilocaine are assigned a category B ranking by the FDA and are therefore safe for use during pregnancy. ... Lignocaine and prilocaine are sold as 2% and 4% formulations, respectively. It is therefore safer to use the lignocaine so as ... E.g. of amide LA: lidocaine, prilocaine, articaine, mepivacaine E.g. of ester LA: benzocaine, procaine Genuine allergic ...
Local anesthetic nerve block
The amides include lidocaine, mepivacaine, prilocaine, bupivacaine, ropivacaine, and levobupivacaine. Chloroprocaine is a short ...
Toluidine
In some patients o-toluidine is a metabolite of prilocaine, which may cause methemoglobinemia. This is then treated with ...
Fear of needles
EMLA is a topical anesthetic cream that is a eutectic mixture of lidocaine and prilocaine. It is a prescription cream in the ... February 2009). "Heated lidocaine/tetracaine patch compared with lidocaine/prilocaine cream for topical anaesthesia before ... "Comparison of iontophoresis of lidocaine with a eutectic mixture of lidocaine and prilocaine (EMLA) for topically administered ...
Herpes simplex
Topical anesthetic treatments such as prilocaine, lidocaine, benzocaine, or tetracaine can also relieve itching and pain. ...
Local anesthetic
This technique is still in use and is remarkably safe when drugs of low systemic toxicity such as prilocaine are used. Spinal ... Examples include: Prilocaine hydrochloride and epinephrine (trade name Citanest Forte) Lidocaine, bupivacaine, and epinephrine ... Topical anesthesia, in the form of lidocaine/prilocaine (EMLA) is most commonly used to enable relatively painless venipuncture ... The systemic toxicity of prilocaine is comparatively low, but its metabolite, o-toluidine, is known to cause methemoglobinemia ...
Felypressin
It is added to some local anaesthetics such as prilocaine in a concentration of 0.03 IU/ml. Felypressin is a Vasopressin 1 ...
Herpes labialis
Anaesthetic creams include lidocaine and prilocaine which has shown reduction in duration of subjective symptoms and eruptions ...
Tumescent anesthesia
Prilocaine is also widely used, although it is not formally approved for tumescent anesthesia in the USA. A combination of ... Kendler, Michael; Simon, Jan C.; Wetzig, Tino (June 2013). "Local anesthesia with lidocaine and prilocaine, using the tumescent ... A double-blind randomized intraindividual study of lidocaine versus prilocaine in tumescent anesthesia for liposuction revealed ... intraindividual comparison study of the efficacy of prilocaine and lidocaine in tumescent local anesthesia". Dermatology (Basel ...
Frenulectomy of the penis
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Analgesic
These topical anesthetics contain anesthetic drugs such as lidocaine, tetracaine, benzocaine, and prilocaine in a cream, ...
Spinal anaesthesia
... prilocaine, or cinchocaine may also be used. Commonly opioids are added to improve the block and provide post-operative pain ...
Intravenous regional anesthesia
A high dose of local anesthetic, typically lidocaine or prilocaine without adrenaline, is slowly injected as distally as ...
Procaine
Like other local anesthetics (such as mepivacaine, and prilocaine), procaine is a vasodilator, thus is often coadministered ...
Paresthesia
... such as lidocaine or prilocaine. Ketamine has also been successfully used, but is generally not approved by insurance. Careful ...
Anesthetic
Amide local anesthetics (such as lidocaine, prilocaine, bupivacaine, levobupivacaine, ropivacaine, mepivacaine, dibucaine and ...
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Methemoglobinemia
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Eutectic system
Lidocaine and prilocaine-both are solids at room temperature-form a eutectic that is an oil with a 16 °C (61 °F) melting point ...
ATC code N01
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List of MeSH codes (D02)
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Articaine
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List of drugs: Prb-Prn
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Methemoglobin
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Cetacaine
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Cardiovascular effects of local anesthetic prilocaine with felypressin 3% and licocaine 2% in normotensive patients
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Lidocaine and prilocaineAnesthesiaEmlaLignocaine and prilocaineHydrochlorideAnaesthetic prilocaineMetaboliteTopicalCreamMethaemoglobinaemiaComplicationPrescriptionCompoundMethemoglobinemiaLocalSalinePatientsWorkDataPureCodeSolutionEMLABupivacaineBenzocaineEpinephrineFelypressinAnesthesiaAnestheticMethemoglobinemia has generally restrictedDose of prilocaine0.03Ortho-toluidineOraqixAmideVasoconstrictorDentalAnaesthesiaSystemicInjectableExtractionsConclusionsMedicationToxicityIntravenous
Lidocaine and prilocaine4
- Liba Lidocaine and prilocaine topical from trusted steroids store. (roidsstore.com)
- EMLA cream is a topical (skin) cream that contains the active substances lidocaine and prilocaine. (europa.eu)
- Emla (lidocaine and prilocaine) is a type of local anaesthetic, which is a numbing medication. (medisave.ca)
- The way in which it works is that the active ingredients lidocaine and prilocaine work together to block the nerve signals in your body, which are associated with pain. (medisave.ca)
Anesthesia6
- Lidocaine / prilocaine topical has an average rating of 7.3 out of 10 from a total of 22 ratings for the treatment of Anesthesia. (drugs.com)
- Many studies show reducing pain during venepuncture after application of prilocaine/lignocaine, but there are few studies that has depicted, the depth of anesthesia produced by prilocaine/lignocaine tends to be too superficial for the reducing the pain during venepuncture. (who.int)
- It is also often combined with lidocaine as a preparation for dermal anesthesia (lidocaine/prilocaine or EMLA), for treatment of conditions like paresthesia. (testosteronerawpowder.com)
- Anesthesia bucal iontophoresis lidocaine mucoadhesion prilocaine. (usp.br)
- Topical anesthesia of gingival mucosa by 5% eutectic mixture of lignocaine and prilocaine or by 10% lignocaine spray. (thejcdp.com)
- The search approach comprised (amniocentesis OR amniocenteses) AND (anesthesia OR "local anesthesia" OR lidocaine OR xylocaine OR EMLA OR "lidocaine-prilocaine" OR lignocaine OR prilocaine OR dalcaine OR xylocitin OR xylesthesin OR xyloneural OR "2-2EtN-2MePhAcN" OR otocaine). (tjoddergisi.org)
Emla8
- Emla (lidocaine / prilocaine) 'I use it when I have sex. (drugs.com)
- Emla (lidocaine / prilocaine) 'Needed an IV insertion for a contrast MRI, and insisted that EMLA be used. (drugs.com)
- Emla (lidocaine / prilocaine) 'I have a phobia of needles, and this is the way to get through blood tests. (drugs.com)
- Emla (lidocaine / prilocaine) 'Hello everyone. (drugs.com)
- Emla (lidocaine / prilocaine) 'I was so so nervous to get a blood test for work but I knew it needed to be done. (drugs.com)
- Emla (lidocaine / prilocaine) 'Without Emla cream I don't know how I would have made it through my cancer treatments. (drugs.com)
- Emla (lidocaine / prilocaine) 'I use Emla with a dermaroller. (drugs.com)
- The CHMP agreed that hypersensitivity (allergy) to lidocaine and/or prilocaine or similar local anaesthetics or to any other ingredients in EMLA cream should be the only contraindication. (europa.eu)
Lignocaine and prilocaine1
- Other 30 patient were applied normal saline as placebo and 30 patient with lignocaine and prilocaine cream. (who.int)
Hydrochloride1
- The combination of lidocaine hydrochloride (LCL) and prilocaine (PCL) is an interesting strategy, since lidocaine begins to act more quickly, but prilocaine has a higher potency. (usp.br)
Anaesthetic prilocaine1
- In patients treated with the anaesthetic prilocaine, ortho-toluidine was detected in urine as a metabolite. (cdc.gov)
Metabolite2
- Ortho-toluidine, a metabolite of the anesthetic prilocaine, also can induce this condition (1). (cdc.gov)
- In some patients, a metabolite of prilocaine may cause the unusual side effect of methemoglobinemia, which may be treated with methylene blue. (testosteronerawpowder.com)
Topical9
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Cream7
- There are no evaluations for Diclofenac-menthol-lidocaine-prilocaine-baclofen cream. (patientslikeme.com)
- Gajbhiye Varsha P., Lamture Y. R.. Anesthetic potential of lidocaine/prilocaine cream versus placebo before venepuncture. (who.int)
- Therefore, authors planned a study to assess anesthetic potential of lidocaine /prilocaine cream versus placebo before venepuncture with help of VAS in an adult patient who were drawn blood sample for investigation purposes.Methods: Prospective interventional study. (who.int)
- 0.05.Conclusions: The present study shows that prilocaine-lidocaine cream reduces the pain of needle puncture in adults and facilitates the procedure of venous blood sampling. (who.int)
- The most commonly used anaesthetics are compound lidocaine/prilocaine cream and tetracaine spray. (bvsalud.org)
- METHODS: Patients scheduled for laparoscopic cholecystectomy or cholecystectomy combined with common bile duct exploration under general anaesthesia were randomly assigned to Group C (saline spray), Group L (2 g compound lidocaine/prilocaine cream contains 5 mg of lidocaine and 5 mg prilocaine)), Group T (tetracaine) and Group F (compound lidocaine/prilocaine cream combined with tetracaine). (bvsalud.org)
- CONCLUSIONS: Compound lidocaine/prilocaine cream combined with tetracaine may be a more effective approach for preventing coughing and stabilising circulation during extubation following general anaesthesia. (bvsalud.org)
Methaemoglobinaemia3
- Abstract Methaemoglobinaemia is a rare complication of prilocaine, mainly affecting individuals with predisposing conditions or those receiving an unusually high dose. (njcc.nl)
- Aetiologically, prilocaine-induced methaemoglobinaemia is a rare form of acquired methaemoglobinaemia, which occurs rarely in the first place. (thieme-connect.com)
- We hope that this report draws the attention of emergency care personnel to the possible diagnosis of prilocaine-induced methaemoglobinaemia after liposuction and encourages more general discussions around the use of prilocaine. (thieme-connect.com)
Complication1
- The following report highlights a potentially dangerous complication arising after application of prilocaine during liposuction. (thieme-connect.com)
Prescription1
- By continuing, you agree to pick up Lidocaine-prilocaine at the above Pharmacy (Prescription will not be valid at any other pharmacy). (myrxvalet.com)
Compound3
- PubChem Compound Summary for CID 4906, Prilocaine. (vibratist.com)
- https://pubchem.ncbi.nlm.nih.gov/compound/Prilocaine. (vibratist.com)
- We speculated that the application of compound lidocaine/prilocaine combined with tetracaine spray would better prevent coughing caused by tracheal extubation. (bvsalud.org)
Methemoglobinemia3
- During March-August 1993, three Wisconsin women treated by the same oral surgeon developed methemoglobinemia after being injected with a prilocaine-based local anesthetic. (cdc.gov)
- Administration of prilocaine in doses exceeding 400 mg has been associated with methemoglobinemia in adults. (cdc.gov)
- The findings in this report indicate that doses of prilocaine only slightly exceeding the recommended therapeutic dose have the potential to cause methemoglobinemia. (cdc.gov)
Local4
- The oral surgeon had administered anesthetic of 560 mg prilocaine (4.4 mg per pound {9.7 mg/kg} of body weight) by local injection and 90 mg methohexital sodium, 10 mg diazepam, and 6 mg dexamethasone sodium phosphate by intravenous infusion. (cdc.gov)
- The oral surgeon had administered 560 mg prilocaine (5.0 mg per pound {11.0 mg/kg} of body weight) by local injection and 60 mg methohexital sodium, 10 mg diazepam, and 0.025 mg fentanyl intravenously. (cdc.gov)
- The oral surgeon had administered 480 mg prilocaine (4.6 mg per pound {10.1 mg/kg} of body weight) by local injection and 7.5 mg diazepam, 6 mg dexamethasone sodium phosphate, and 0.025 mg fentanyl intravenously. (cdc.gov)
- Editorial Note: Prilocaine is a lidocaine homologue and the only secondary amine local anesthetic that remains in clinical use. (cdc.gov)
Saline1
- 30 patients selected in study group received lignocaine/prilocaine locally, 30min prior to venepuncture which was later covered with occlusive tape, whereas 30 control group patient received normal saline locally as placebo. (who.int)
Patients2
- The aim of this study was to evaluate the cardiovascular effects of intraoral lidocaine clhoridrate 2% (20 mg/mL) and prilocaine clhoridrate 3% (30 mg/mL) with (0.03 U.l/mL) felipressin infiltrative administration in ASAI patients. (bvsalud.org)
- Furthermore, ortho-toluidine-haemoglobin adducts have been identified in exposed workers, as well as in patients treated with prilocaine. (cdc.gov)
Work1
- We work on our toes to formulate the Prilocaine USP/BP/EP according to your industry needs. (mentholcristales.com)
Data1
- all data on Lidocaine/prilocaine (Premature Ejaculation) or data on Lidocaine/prilocaine (Premature Ejaculation) by Sub-ICB Location . (openprescribing.net)
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Code1
- High-level prescribing trends for Lidocaine/prilocaine (Premature Ejaculation) (BNF code 0704060B0) across all GP practices in NHS England for the last five years. (openprescribing.net)
Solution1
- A large volume of an anaesthetic solution containing prilocaine had been injected into the tissue. (thieme-connect.com)
EMLA13
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- It is also often combined with lidocaine as a preparation for dermal anesthesia (lidocaine/prilocaine or EMLA), for treatment of conditions like paresthesia. (biosteroids.com)
- Prilocaine is a local anesthetic of the amino amide type first prepared by Claes Tegner and Nils Lö Fgren.In its injectable form (trade name Citanest), it is often used in dentistry.It is also often combined with lidocaine as a preparation for dermal anesthesia (lidocaine/prilocaine or EMLA), for treatment of conditions like paresthesia.As it has low cardiac toxicity, it is commonly used for intravenous regional anaesthesia (IVRA). (pharmaapis.com)
- A Double-Blind, Randomised, Placebo-Controlled Trial of EMLA® Cream (Eutectic Lidocaine/Prilocaine Cream). (annals.edu.sg)
- To desensitize only the skin and upper subcutaneous layers, eutectic mixture of local anaesthetics (EMLA) cream (lidocaine and prilocaine) (generally used to aid vascular catheterization). (vin.com)
- The association between prilocaine and methemoglobinemia has generally restricted prilocaine use in infants and children to the eutectic mixture of local anesthetics (EMLA). (nih.gov)
- Individuals who are currently taking medication that may cause methemoglobinemia such as nitrates derivatives, sulfonamides, dapsone, phenacetin, phenazopyridine, some local anesthetics such as prilocaine, topical anesthetics such as emla cream, benzocaine. (nih.gov)
- RESULTS: Dermatologists who perceived that licensing was required for INE were significantly more likely to refer patients to INE for hair removal (P = 0.001) and prescribe EMLA cream (lidocaine 2.5% and prilocaine 2.5%) to patients requesting it for electrolysis performed by INE (P = 0.001). (hairfacts.com)
- Emla is a mixture of two local anaesthetics, lignocaine and prilocaine. (dissectpodcast.com)
Bupivacaine4
- Within the limitations of this study it is concluded that bupivacaine 0.75% compared to prilocaine 3% showed no statistically significant cardiovascular changes and marked intrinsic vasoconstrictor effects were not observed in this study. (oatext.com)
- People who are allergic to lidocaine or other amide-type local anaesthetics, eg bupivacaine, prilocaine. (netdoctor.co.uk)
- LAs contain an aromatic ring (lipophilic) at one end and an ionizable group at the other and an intermediate chain in between, which can be either an ester (tetracaine, procaine, benzocaine) or an amide (lidocaine, bupivacaine, ropivacaine, mepivacaine, prilocaine and their respective mono-isomers). (vin.com)
- They should not be used by children and adolescents under 18 years of age, or by people who are allergic to local anaesthetics such as bupivacaine, etidocaine, mepivacaine or prilocaine. (netdoctor.co.uk)
Benzocaine2
- Ester (prilocaine, benzocaine) LAs may cause allergic reactions in some animals and methemoglobinemia in cats. (vin.com)
- These anesthetic creams and sprays contain a numbing agent, such as benzocaine, lidocaine or prilocaine, which should be applied to the penis 10 to 15 minutes before sex to reduce sensation and subsequently delay ejaculation. (askmen.com)
Epinephrine5
- 4% Citanest ® Forte DENTAL with Epinephrine 1:200,000 (Citanest Forte), Prilocaine HCl 4% (72 mg/1.8 mL) (40 mg/mL) with Epinephrine 1:200,000 Injection, is a sterile, non-pyrogenic isotonic solution that contains a local anesthetic agent with epinephrine (as bitartrate) and is administered parenterally by injection. (nih.gov)
- The aim of this study was to compare the effectiveness of 2% lidocaine with epinephrine (1:100,000) and 3% prilocaine with felypressin (0.03 I.U. per ml) and the possibility of using them in the oral surgery of medically compromised patients. (org.sa)
- There are no practical clinical differences between prilocaine with and without epinephrine when used for inferior alveolar blocks. (drugs.com)
- For long procedures, or those involving maxillary posterior teeth where soft tissue numbness is not troublesome to the patient, Prilocaine HCl 4% with epinephrine 1:200,000 is recommended. (drugs.com)
- Active ingredient composition: 5% lidocaine, 5% prilocaine and 1% epinephrine. (crowandbutterfly.com)
Felypressin7
- General anesthesia was performed, during which 3% prilocaine with 0.03 IU/mL felypressin was administered intraoperatively via infiltration. (nih.gov)
- Patients treatment group II received prilocaine 3% and felypressin 0.03 I.U. per ml. (org.sa)
- Prilocaine with felypressin could be a good choice for patients who have contraindication to the use of lidocaine with adrenaline. (org.sa)
- Felypressin added to prilocaine in a concentration of 0.03 IU/ml. (org.sa)
- In light of these facts, prilocaine with felypressin could be of value to be used in medically compromised patients because it has less vasodilation, toxicity and fewer hemodynamic effects than lidocaine with adrenaline. (org.sa)
- Group two received prilocaine with 3% felypressin (0.03 I.U. per ml). (saudija.org)
- 3% Prilocaine with felypressin is as effective as 4% articaine with adrenaline when used for the extraction of maxillary teeth. (saudija.org)
Anesthesia10
- Local anesthesia with prilocaine has become a routine part of ambulatory circumcision procedures. (medscape.com)
- We report the case of a 40-day-old Turkish boy who presented with cyanosis after receiving local anesthesia with prilocaine. (medscape.com)
- For a variety of surgical epidural block and infiltration anesthesia Prilocaine topical is a local anesthetic (numbing medication).It works by blocking nerve signals in your body.Prilocaine topical is used to numb the skin, or surfaces of the penis or vagina, in preparation for a medical procedure or to lessen the pain of inserting a medical instrument such as a tube or speculum. (pharmaapis.com)
- Thus, it is objective of this study comparing the effects of ropivacaine and prilocaine in the cardiovascular system when used in simple extractions procedures after the blockade in anesthesia infiltrating terminals jaw. (oatext.com)
- There were no significant differences in the mean onset time of pulpal anesthesia and extraction between the prilocaine and lidocaine buccal infiltration groups ( p =0.28). (org.sa)
- However, clinically, the patients in prilocaine group recorded faster onset time of anesthesia and teeth extraction than those in lidocaine group. (org.sa)
- Prilocaine has a better clinical performance in terms of providing rapid dental anesthesia and earlier teeth extraction than lidocaine but the differences were not significant. (org.sa)
- Pulse-Oximetric Measurement of Prilocaine-Induced Methemoglobinemia in Regional Anesthesia. (masimo.com)
- However, there were six patients with failure anesthesia (5 in prilocaine group and 1 in articaine group). (saudija.org)
- T-test showed that there have been no important variations within the mean onset time of anesthesia for articaine and prilocaine buccal infiltrations ( P = 0.1). (saudija.org)
Anesthetic13
- Lidocaine 2.5% and Prilocaine 2.5%, a topical anesthetic agent, is an emulsion in which the oil phase is a eutectic mixture of lidocaine and prilocaine in a ratio of 1:1 by weight. (nih.gov)
- Lidocaine and prilocaine are amide-type local anesthetic agents. (nih.gov)
- Both lidocaine and prilocaine stabilize neuronal membranes by inhibiting the ionic fluxes required for the initiation and conduction of impulses, thereby effecting local anesthetic action. (nih.gov)
- Prilocaine stabilizes the neuronal membrane by inhibiting the ionic fluxes required for the initiation and conduction of impulses, thereby effecting local anesthetic action. (nih.gov)
- As with other local anesthetic agents, the plasma binding of prilocaine may be dependent on drug concentration. (nih.gov)
- Prilocaine topical is a local anesthetic (numbing medication).It works by blocking nerve signals in your body. (pharmaapis.com)
- To this end, 14 healthy patients (Class 1 - anesthetic risk rating recommended by the American Society of Anesthesiology) were selected and received anesthetic infiltration of 3.6 mL of 0.75% ropivacaine and 3.6 ml of prilocaine 3% for extraction of third molars jaw. (oatext.com)
- 1 - 4 Lidocaine and prilocaine are amide local anesthetic agents but prilocaine is less toxic and vasodilator than lidocaine. (org.sa)
- 13. Hemoglobin adducts of the human bladder carcinogen o-toluidine after treatment with the local anesthetic prilocaine. (nih.gov)
- The use of lidocaine/ prilocaine anesthetic ointment instead of injectable local lidocaine in transradial catheterization was found to be equally effective. (medscape.com)
- Prilocaine is a topical anesthetic that causes loss of feeling in the skin and surrounding tissues. (dissectpodcast.com)
- To compare the anesthetic performances of 3% prilocaine and 4% articaine when used for the extraction of the maxillary teeth. (saudija.org)
- By applying Person's Chi-square test (x2), there were no significant differences in the number of episodes of the anesthetic success between articaine and prilocaine groups at time intervals ( P = 0.5). (saudija.org)
Methemoglobinemia has generally restricted1
- Although the association between prilocaine use and methemoglobinemia has generally restricted the use of prilocaine in babies, it is still widely used in ambulatory procedures, especially during circumcision in the neonatal period. (medscape.com)
Dose of prilocaine1
- Based on the low excretion of other local anesthetics into breastmilk, a single dose of prilocaine injected during breastfeeding, such as for a dental procedure, is unlikely to adversely affect the breastfed infant. (nih.gov)
0.031
- The aim of this study was to evaluate the cardiovascular effects of intraoral lidocaine clhoridrate 2% (20 mg/mL) and prilocaine clhoridrate 3% (30 mg/mL) with (0.03 U.l/mL) felipressin infiltrative administration in ASAI patients. (bvsalud.org)
Ortho-toluidine2
Oraqix2
- The Institute has been ranked No. Nestled in the serene setting of a beautiful countryside, Pakistan Institute of Engineering and Applied Sciences (PIEAS), Islamabad, is recognized as a Oraqix (Lidocaine and Prilocaine Periodontal Gel)- FDA federal Orqqix university devoted to higher education in specific disciplines of engineering, natural sciences and formal sciences. (tbly.xyz)
- The aim of the work was to Oraqix (Lidocaine and Prilocaine Periodontal Gel)- FDA the effect of Oraqix (Lidocaine and Prilocaine Periodontal Gel)- FDA BNC dehydration followed by rehydration on its mechanical and physicochemical properties, in the context of Oraqix (Lidocaine and Prilocaine Periodontal Gel)- FDA use of BNC as bio-prostheses in the cardiovascular system. (tbly.xyz)
Amide1
- This medication contains 2 amide-type local anesthetics, lidocaine and prilocaine. (webmd.com)
Vasoconstrictor2
- Information derived from diverse formulations, concentrations and usages reveals that prilocaine is completely absorbed following parenteral administration, its rate of absorption depending, for example, upon such factors as the site of administration and the presence or absence of a vasoconstrictor agent. (nih.gov)
- 5 So, prilocaine can be a good choice for patients for whom vasoconstrictor is contraindicated. (org.sa)
Dental3
- Limited information is currently available on methemoglobinemia caused by the administration of prilocaine in children undergoing dental procedures in Japan. (nih.gov)
- Methemoglobin Levels in Generally Anesthetized Pediatric Dental Patients Receiving Prilocaine versus Lidocaine. (masimo.com)
- Recommendations would be given to the dental practitioners to use prilocaine more frequently than articaine because of its low toxicity. (saudija.org)
Anaesthesia1
- Pulse Oximeter Methemoglobin Measurements in Patients with Tumescent Anaesthesia and Prilocaine. (masimo.com)
Systemic1
- Factors such as acidosis and the use of CNS stimulants and depressants affect the CNS levels of prilocaine required to produce overt systemic effects. (nih.gov)
Injectable1
- Only two (lidocaine and prilocaine) are available as both topical and injectable agents in dentistry. (cdeworld.com)
Extractions1
- To investigate the potency and speed of action of 2% lidocaine and 3% prilocaine for upper teeth extractions. (org.sa)
Conclusions1
- An overview of Genetic Toxicology Bacterial Mutagenicity study conclusions related to Prilocaine (721-50-6). (nih.gov)
Medication1
- Prilocaine topical may also be used for other purposes not listed in this medication guide. (pharmaapis.com)
Toxicity1
- Genetic Toxicity Evaluation of Prilocaine in Salmonella/E.coli Mutagenicity Test or Ames Test. (nih.gov)
Intravenous1
- [ 6 ] We report a patient with prilocaine-induced acquired methemoglobinemia and discuss the use of intravenous methylene blue treatment. (medscape.com)