The soft tissue filling the cavities of bones. Bone marrow exists in two types, yellow and red. Yellow marrow is found in the large cavities of large bones and consists mostly of fat cells and a few primitive blood cells. Red marrow is a hematopoietic tissue and is the site of production of erythrocytes and granular leukocytes. Bone marrow is made up of a framework of connective tissue containing branching fibers with the frame being filled with marrow cells.
Cells contained in the bone marrow including fat cells (see ADIPOCYTES); STROMAL CELLS; MEGAKARYOCYTES; and the immediate precursors of most blood cells.
The transference of BONE MARROW from one human or animal to another for a variety of purposes including HEMATOPOIETIC STEM CELL TRANSPLANTATION or MESENCHYMAL STEM CELL TRANSPLANTATION.
A specialized CONNECTIVE TISSUE that is the main constituent of the SKELETON. The principle cellular component of bone is comprised of OSTEOBLASTS; OSTEOCYTES; and OSTEOCLASTS, while FIBRILLAR COLLAGENS and hydroxyapatite crystals form the BONE MATRIX.
The continuous turnover of BONE MATRIX and mineral that involves first an increase in BONE RESORPTION (osteoclastic activity) and later, reactive BONE FORMATION (osteoblastic activity). The process of bone remodeling takes place in the adult skeleton at discrete foci. The process ensures the mechanical integrity of the skeleton throughout life and plays an important role in calcium HOMEOSTASIS. An imbalance in the regulation of bone remodeling's two contrasting events, bone resorption and bone formation, results in many of the metabolic bone diseases, such as OSTEOPOROSIS.
Removal of bone marrow and evaluation of its histologic picture.
Neoplasms located in the bone marrow. They are differentiated from neoplasms composed of bone marrow cells, such as MULTIPLE MYELOMA. Most bone marrow neoplasms are metastatic.
Progenitor cells from which all blood cells derive.
The amount of mineral per square centimeter of BONE. This is the definition used in clinical practice. Actual bone density would be expressed in grams per milliliter. It is most frequently measured by X-RAY ABSORPTIOMETRY or TOMOGRAPHY, X RAY COMPUTED. Bone density is an important predictor for OSTEOPOROSIS.
Bone loss due to osteoclastic activity.
Techniques for the removal of subpopulations of cells (usually residual tumor cells) from the bone marrow ex vivo before it is infused. The purging is achieved by a variety of agents including pharmacologic agents, biophysical agents (laser photoirradiation or radioisotopes) and immunologic agents. Bone marrow purging is used in both autologous and allogeneic BONE MARROW TRANSPLANTATION.
The development and formation of various types of BLOOD CELLS. Hematopoiesis can take place in the BONE MARROW (medullary) or outside the bone marrow (HEMATOPOIESIS, EXTRAMEDULLARY).
Tumors or cancer located in bone tissue or specific BONES.
Transplantation between individuals of the same species. Usually refers to genetically disparate individuals in contradistinction to isogeneic transplantation for genetically identical individuals.
The growth and development of bones from fetus to adult. It includes two principal mechanisms of bone growth: growth in length of long bones at the epiphyseal cartilages and growth in thickness by depositing new bone (OSTEOGENESIS) with the actions of OSTEOBLASTS and OSTEOCLASTS.
Diseases of BONES.
A cytologic technique for measuring the functional capacity of stem cells by assaying their activity.
Progressive restriction of the developmental potential and increasing specialization of function that leads to the formation of specialized cells, tissues, and organs.
Renewal or repair of lost bone tissue. It excludes BONY CALLUS formed after BONE FRACTURES but not yet replaced by hard bone.
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.
Irradiation of the whole body with ionizing or non-ionizing radiation. It is applicable to humans or animals but not to microorganisms.
Transplantation of an individual's own tissue from one site to another site.
An organism whose body contains cell populations of different genotypes as a result of the TRANSPLANTATION of donor cells after sufficient ionizing radiation to destroy the mature recipient's cells which would otherwise reject the donor cells.
Connective tissue cells of an organ found in the loose connective tissue. These are most often associated with the uterine mucosa and the ovary as well as the hematopoietic system and elsewhere.
The clinical entity characterized by anorexia, diarrhea, loss of hair, leukopenia, thrombocytopenia, growth retardation, and eventual death brought about by the GRAFT VS HOST REACTION.
A form of anemia in which the bone marrow fails to produce adequate numbers of peripheral blood elements.
The process of bone formation. Histogenesis of bone including ossification.
Technique using an instrument system for making, processing, and displaying one or more measurements on individual cells obtained from a cell suspension. Cells are usually stained with one or more fluorescent dyes specific to cell components of interest, e.g., DNA, and fluorescence of each cell is measured as it rapidly transverses the excitation beam (laser or mercury arc lamp). Fluorescence provides a quantitative measure of various biochemical and biophysical properties of the cell, as well as a basis for cell sorting. Other measurable optical parameters include light absorption and light scattering, the latter being applicable to the measurement of cell size, shape, density, granularity, and stain uptake.
A progressive, malignant disease of the blood-forming organs, characterized by distorted proliferation and development of leukocytes and their precursors in the blood and bone marrow. Leukemias were originally termed acute or chronic based on life expectancy but now are classified according to cellular maturity. Acute leukemias consist of predominately immature cells; chronic leukemias are composed of more mature cells. (From The Merck Manual, 2006)
Extracellular substance of bone tissue consisting of COLLAGEN fibers, ground substance, and inorganic crystalline minerals and salts.
The grafting of bone from a donor site to a recipient site.
Glycoproteins found on immature hematopoietic cells and endothelial cells. They are the only molecules to date whose expression within the blood system is restricted to a small number of progenitor cells in the bone marrow.
Leukocytes with abundant granules in the cytoplasm. They are divided into three groups according to the staining properties of the granules: neutrophilic, eosinophilic, and basophilic. Mature granulocytes are the NEUTROPHILS; EOSINOPHILS; and BASOPHILS.
An encapsulated lymphatic organ through which venous blood filters.
Bone-forming cells which secrete an EXTRACELLULAR MATRIX. HYDROXYAPATITE crystals are then deposited into the matrix to form bone.
A large multinuclear cell associated with the BONE RESORPTION. An odontoclast, also called cementoclast, is cytomorphologically the same as an osteoclast and is involved in CEMENTUM resorption.
Transfer of HEMATOPOIETIC STEM CELLS from BONE MARROW or BLOOD between individuals within the same species (TRANSPLANTATION, HOMOLOGOUS) or transfer within the same individual (TRANSPLANTATION, AUTOLOGOUS). Hematopoietic stem cell transplantation has been used as an alternative to BONE MARROW TRANSPLANTATION in the treatment of a variety of neoplasms.
An organism that, as a result of transplantation of donor tissue or cells, consists of two or more cell lines descended from at least two zygotes. This state may result in the induction of donor-specific TRANSPLANTATION TOLERANCE.
A malignancy of mature PLASMA CELLS engaging in monoclonal immunoglobulin production. It is characterized by hyperglobulinemia, excess Bence-Jones proteins (free monoclonal IMMUNOGLOBULIN LIGHT CHAINS) in the urine, skeletal destruction, bone pain, and fractures. Other features include ANEMIA; HYPERCALCEMIA; and RENAL INSUFFICIENCY.
Deficiency of all three cell elements of the blood, erythrocytes, leukocytes and platelets.
Clonal expansion of myeloid blasts in bone marrow, blood, and other tissue. Myeloid leukemias develop from changes in cells that normally produce NEUTROPHILS; BASOPHILS; EOSINOPHILS; and MONOCYTES.
Elements of limited time intervals, contributing to particular results or situations.
Synthetic or natural materials for the replacement of bones or bone tissue. They include hard tissue replacement polymers, natural coral, hydroxyapatite, beta-tricalcium phosphate, and various other biomaterials. The bone substitutes as inert materials can be incorporated into surrounding tissue or gradually replaced by original tissue.
Very large BONE MARROW CELLS which release mature BLOOD PLATELETS.
Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.
Relatively undifferentiated cells that retain the ability to divide and proliferate throughout postnatal life to provide progenitor cells that can differentiate into specialized cells.
The developmental history of specific differentiated cell types as traced back to the original STEM CELLS in the embryo.
Clonal hematopoietic stem cell disorders characterized by dysplasia in one or more hematopoietic cell lineages. They predominantly affect patients over 60, are considered preleukemic conditions, and have high probability of transformation into ACUTE MYELOID LEUKEMIA.
The longest and largest bone of the skeleton, it is situated between the hip and the knee.
Process of classifying cells of the immune system based on structural and functional differences. The process is commonly used to analyze and sort T-lymphocytes into subsets based on CD antigens by the technique of flow cytometry.
A glycoprotein of MW 25 kDa containing internal disulfide bonds. It induces the survival, proliferation, and differentiation of neutrophilic granulocyte precursor cells and functionally activates mature blood neutrophils. Among the family of colony-stimulating factors, G-CSF is the most potent inducer of terminal differentiation to granulocytes and macrophages of leukemic myeloid cell lines.
Breaks in bones.
Lymphocytes responsible for cell-mediated immunity. Two types have been identified - cytotoxic (T-LYMPHOCYTES, CYTOTOXIC) and helper T-lymphocytes (T-LYMPHOCYTES, HELPER-INDUCER). They are formed when lymphocytes circulate through the THYMUS GLAND and differentiate to thymocytes. When exposed to an antigen, they divide rapidly and produce large numbers of new T cells sensitized to that antigen.
Form of leukemia characterized by an uncontrolled proliferation of the myeloid lineage and their precursors (MYELOID PROGENITOR CELLS) in the bone marrow and other sites.
The survival of a graft in a host, the factors responsible for the survival and the changes occurring within the graft during growth in the host.
Laboratory mice that have been produced from a genetically manipulated EGG or EMBRYO, MAMMALIAN.
Bone-growth regulatory factors that are members of the transforming growth factor-beta superfamily of proteins. They are synthesized as large precursor molecules which are cleaved by proteolytic enzymes. The active form can consist of a dimer of two identical proteins or a heterodimer of two related bone morphogenetic proteins.
Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the LIVER to form the active aldophosphamide. It has been used in the treatment of LYMPHOMA and LEUKEMIA. Its side effect, ALOPECIA, has been used for defleecing sheep. Cyclophosphamide may also cause sterility, birth defects, mutations, and cancer.
A potent osteoinductive protein that plays a critical role in the differentiation of osteoprogenitor cells into OSTEOBLASTS.
Bone-marrow-derived, non-hematopoietic cells that support HEMATOPOETIC STEM CELLS. They have also been isolated from other organs and tissues such as UMBILICAL CORD BLOOD, umbilical vein subendothelium, and WHARTON JELLY. These cells are considered to be a source of multipotent stem cells because they include subpopulations of mesenchymal stem cells.
The cells found in the body fluid circulating throughout the CARDIOVASCULAR SYSTEM.
Differentiation antigens residing on mammalian leukocytes. CD stands for cluster of differentiation, which refers to groups of monoclonal antibodies that show similar reactivity with certain subpopulations of antigens of a particular lineage or differentiation stage. The subpopulations of antigens are also known by the same CD designation.
The number of WHITE BLOOD CELLS per unit volume in venous BLOOD. A differential leukocyte count measures the relative numbers of the different types of white cells.
The number of CELLS of a specific kind, usually measured per unit volume or area of sample.
The production of red blood cells (ERYTHROCYTES). In humans, erythrocytes are produced by the YOLK SAC in the first trimester; by the liver in the second trimester; by the BONE MARROW in the third trimester and after birth. In normal individuals, the erythrocyte count in the peripheral blood remains relatively constant implying a balance between the rate of erythrocyte production and rate of destruction.
The fission of a CELL. It includes CYTOKINESIS, when the CYTOPLASM of a cell is divided, and CELL NUCLEUS DIVISION.
The number of LEUKOCYTES and ERYTHROCYTES per unit volume in a sample of venous BLOOD. A complete blood count (CBC) also includes measurement of the HEMOGLOBIN; HEMATOCRIT; and ERYTHROCYTE INDICES.
A single, unpaired primary lymphoid organ situated in the MEDIASTINUM, extending superiorly into the neck to the lower edge of the THYROID GLAND and inferiorly to the fourth costal cartilage. It is necessary for normal development of immunologic function early in life. By puberty, it begins to involute and much of the tissue is replaced by fat.
A neoplasm characterized by abnormalities of the lymphoid cell precursors leading to excessive lymphoblasts in the marrow and other organs. It is the most common cancer in children and accounts for the vast majority of all childhood leukemias.
A de novo myeloproliferation arising from an abnormal stem cell. It is characterized by the replacement of bone marrow by fibrous tissue, a process that is mediated by CYTOKINES arising from the abnormal clone.
Clonal hematopoetic disorder caused by an acquired genetic defect in PLURIPOTENT STEM CELLS. It starts in MYELOID CELLS of the bone marrow, invades the blood and then other organs. The condition progresses from a stable, more indolent, chronic phase (LEUKEMIA, MYELOID, CHRONIC PHASE) lasting up to 7 years, to an advanced phase composed of an accelerated phase (LEUKEMIA, MYELOID, ACCELERATED PHASE) and BLAST CRISIS.
An alkylating agent having a selective immunosuppressive effect on BONE MARROW. It has been used in the palliative treatment of chronic myeloid leukemia (MYELOID LEUKEMIA, CHRONIC), but although symptomatic relief is provided, no permanent remission is brought about. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), busulfan is listed as a known carcinogen.
An individual that contains cell populations derived from different zygotes.
The second longest bone of the skeleton. It is located on the medial side of the lower leg, articulating with the FIBULA laterally, the TALUS distally, and the FEMUR proximally.
Individuals supplying living tissue, organs, cells, blood or blood components for transfer or transplantation to histocompatible recipients.
Preparative treatment of transplant recipient with various conditioning regimens including radiation, immune sera, chemotherapy, and/or immunosuppressive agents, prior to transplantation. Transplantation conditioning is very common before bone marrow transplantation.
The relatively long-lived phagocytic cell of mammalian tissues that are derived from blood MONOCYTES. Main types are PERITONEAL MACROPHAGES; ALVEOLAR MACROPHAGES; HISTIOCYTES; KUPFFER CELLS of the liver; and OSTEOCLASTS. They may further differentiate within chronic inflammatory lesions to EPITHELIOID CELLS or may fuse to form FOREIGN BODY GIANT CELLS or LANGHANS GIANT CELLS. (from The Dictionary of Cell Biology, Lackie and Dow, 3rd ed.)
Antibodies produced by a single clone of cells.
Benign unilocular lytic areas in the proximal end of a long bone with well defined and narrow endosteal margins. The cysts contain fluid and the cyst walls may contain some giant cells. Bone cysts usually occur in males between the ages 3-15 years.
Specialized forms of antibody-producing B-LYMPHOCYTES. They synthesize and secrete immunoglobulin. They are found only in lymphoid organs and at sites of immune responses and normally do not circulate in the blood or lymph. (Rosen et al., Dictionary of Immunology, 1989, p169 & Abbas et al., Cellular and Molecular Immunology, 2d ed, p20)
An acidic glycoprotein of MW 23 kDa with internal disulfide bonds. The protein is produced in response to a number of inflammatory mediators by mesenchymal cells present in the hemopoietic environment and at peripheral sites of inflammation. GM-CSF is able to stimulate the production of neutrophilic granulocytes, macrophages, and mixed granulocyte-macrophage colonies from bone marrow cells and can stimulate the formation of eosinophil colonies from fetal liver progenitor cells. GM-CSF can also stimulate some functional activities in mature granulocytes and macrophages.
Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations, or by parent x offspring matings carried out with certain restrictions. All animals within an inbred strain trace back to a common ancestor in the twentieth generation.
Glycoproteins found in a subfraction of normal mammalian plasma and urine. They stimulate the proliferation of bone marrow cells in agar cultures and the formation of colonies of granulocytes and/or macrophages. The factors include INTERLEUKIN-3; (IL-3); GRANULOCYTE COLONY-STIMULATING FACTOR; (G-CSF); MACROPHAGE COLONY-STIMULATING FACTOR; (M-CSF); and GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; (GM-CSF).
Identification of the major histocompatibility antigens of transplant DONORS and potential recipients, usually by serological tests. Donor and recipient pairs should be of identical ABO blood group, and in addition should be matched as closely as possible for HISTOCOMPATIBILITY ANTIGENS in order to minimize the likelihood of allograft rejection. (King, Dictionary of Genetics, 4th ed)
Transfer of MESENCHYMAL STEM CELLS between individuals within the same species (TRANSPLANTATION, HOMOLOGOUS) or transfer within the same individual (TRANSPLANTATION, AUTOLOGOUS).
Transplantation between genetically identical individuals, i.e., members of the same species with identical histocompatibility antigens, such as monozygotic twins, members of the same inbred strain, or members of a hybrid population produced by crossing certain inbred strains.
All of the processes involved in increasing CELL NUMBER including CELL DIVISION.
A CXC chemokine that is chemotactic for T-LYMPHOCYTES and MONOCYTES. It has specificity for CXCR4 RECEPTORS. Two isoforms of CXCL12 are produced by alternative mRNA splicing.
Disorders of the blood and blood forming tissues.
Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.
The degree of antigenic similarity between the tissues of different individuals, which determines the acceptance or rejection of allografts.
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
The movement of cells from one location to another. Distinguish from CYTOKINESIS which is the process of dividing the CYTOPLASM of a cell.
Formation of LYMPHOCYTES and PLASMA CELLS from the lymphoid stem cells which develop from the pluripotent HEMATOPOIETIC STEM CELLS in the BONE MARROW. These lymphoid stem cells differentiate into T-LYMPHOCYTES; B-LYMPHOCYTES; PLASMA CELLS; or NK-cells (KILLER CELLS, NATURAL) depending on the organ or tissues (LYMPHOID TISSUE) to which they migrate.
An enzyme that catalyzes the conversion of an orthophosphoric monoester and water to an alcohol and orthophosphate. EC 3.1.3.1.
Either of a pair of compound bones forming the lateral (left and right) surfaces and base of the skull which contains the organs of hearing. It is a large bone formed by the fusion of parts: the squamous (the flattened anterior-superior part), the tympanic (the curved anterior-inferior part), the mastoid (the irregular posterior portion), and the petrous (the part at the base of the skull).
The treatment of a disease or condition by several different means simultaneously or sequentially. Chemoimmunotherapy, RADIOIMMUNOTHERAPY, chemoradiotherapy, cryochemotherapy, and SALVAGE THERAPY are seen most frequently, but their combinations with each other and surgery are also used.
A group of genetically identical cells all descended from a single common ancestral cell by mitosis in eukaryotes or by binary fission in prokaryotes. Clone cells also include populations of recombinant DNA molecules all carrying the same inserted sequence. (From King & Stansfield, Dictionary of Genetics, 4th ed)
Lymphoid cells concerned with humoral immunity. They are short-lived cells resembling bursa-derived lymphocytes of birds in their production of immunoglobulin upon appropriate stimulation.
Therapeutic act or process that initiates a response to a complete or partial remission level.
Process by which organic tissue becomes hardened by the physiologic deposit of calcium salts.
Disease having a short and relatively severe course.
The release of stem cells from the bone marrow into the peripheral blood circulation for the purpose of leukapheresis, prior to stem cell transplantation. Hematopoietic growth factors or chemotherapeutic agents often are used to stimulate the mobilization.
Reduction of bone mass without alteration in the composition of bone, leading to fractures. Primary osteoporosis can be of two major types: postmenopausal osteoporosis (OSTEOPOROSIS, POSTMENOPAUSAL) and age-related or senile osteoporosis.
A technique of culturing mixed cell types in vitro to allow their synergistic or antagonistic interactions, such as on CELL DIFFERENTIATION or APOPTOSIS. Coculture can be of different types of cells, tissues, or organs from normal or disease states.
Proteins prepared by recombinant DNA technology.
One of a pair of irregularly shaped quadrilateral bones situated between the FRONTAL BONE and OCCIPITAL BONE, which together form the sides of the CRANIUM.
White blood cells formed in the body's lymphoid tissue. The nucleus is round or ovoid with coarse, irregularly clumped chromatin while the cytoplasm is typically pale blue with azurophilic (if any) granules. Most lymphocytes can be classified as either T or B (with subpopulations of each), or NATURAL KILLER CELLS.
Any of a group of malignant tumors of lymphoid tissue that differ from HODGKIN DISEASE, being more heterogeneous with respect to malignant cell lineage, clinical course, prognosis, and therapy. The only common feature among these tumors is the absence of giant REED-STERNBERG CELLS, a characteristic of Hodgkin's disease.
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment.
Histochemical localization of immunoreactive substances using labeled antibodies as reagents.
The cells in the erythroid series derived from MYELOID PROGENITOR CELLS or from the bi-potential MEGAKARYOCYTE-ERYTHROID PROGENITOR CELLS which eventually give rise to mature RED BLOOD CELLS. The erythroid progenitor cells develop in two phases: erythroid burst-forming units (BFU-E) followed by erythroid colony-forming units (CFU-E); BFU-E differentiate into CFU-E on stimulation by ERYTHROPOIETIN, and then further differentiate into ERYTHROBLASTS when stimulated by other factors.
In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.
A hematopoietic growth factor and the ligand of the cell surface c-kit protein (PROTO-ONCOGENE PROTEINS C-KIT). It is expressed during embryogenesis and is a growth factor for a number of cell types including the MAST CELLS and the MELANOCYTES in addition to the HEMATOPOIETIC STEM CELLS.
The return of a sign, symptom, or disease after a remission.
The largest of three bones that make up each half of the pelvic girdle.
A variation of the PCR technique in which cDNA is made from RNA via reverse transcription. The resultant cDNA is then amplified using standard PCR protocols.
The span of viability of a cell characterized by the capacity to perform certain functions such as metabolism, growth, reproduction, some form of responsiveness, and adaptability.
A transmembrane protein belonging to the tumor necrosis factor superfamily that specifically binds RECEPTOR ACTIVATOR OF NUCLEAR FACTOR-KAPPA B and OSTEOPROTEGERIN. It plays an important role in regulating OSTEOCLAST differentiation and activation.
A general term for various neoplastic diseases of the lymphoid tissue.
Immunosuppression by reduction of circulating lymphocytes or by T-cell depletion of bone marrow. The former may be accomplished in vivo by thoracic duct drainage or administration of antilymphocyte serum. The latter is performed ex vivo on bone marrow before its transplantation.
High-molecular weight glycoproteins uniquely expressed on the surface of LEUKOCYTES and their hemopoietic progenitors. They contain a cytoplasmic protein tyrosine phosphatase activity which plays a role in intracellular signaling from the CELL SURFACE RECEPTORS. The CD45 antigens occur as multiple isoforms that result from alternative mRNA splicing and differential usage of three exons.
Vitamin K-dependent calcium-binding protein synthesized by OSTEOBLASTS and found primarily in BONES. Serum osteocalcin measurements provide a noninvasive specific marker of bone metabolism. The protein contains three residues of the amino acid gamma-carboxyglutamic acid (Gla), which, in the presence of CALCIUM, promotes binding to HYDROXYAPATITE and subsequent accumulation in BONE MATRIX.
A group of lymphocyte surface antigens located on mouse LYMPHOCYTES. Specific Ly antigens are useful markers for distinguishing subpopulations of lymphocytes.
Neoplasms located in the blood and blood-forming tissue (the bone marrow and lymphatic tissue). The commonest forms are the various types of LEUKEMIA, of LYMPHOMA, and of the progressive, life-threatening forms of the MYELODYSPLASTIC SYNDROMES.
A protein-tyrosine kinase receptor that is specific for STEM CELL FACTOR. This interaction is crucial for the development of hematopoietic, gonadal, and pigment stem cells. Genetic mutations that disrupt the expression of PROTO-ONCOGENE PROTEINS C-KIT are associated with PIEBALDISM, while overexpression or constitutive activation of the c-kit protein-tyrosine kinase is associated with tumorigenesis.
Mice homozygous for the mutant autosomal recessive gene "scid" which is located on the centromeric end of chromosome 16. These mice lack mature, functional lymphocytes and are thus highly susceptible to lethal opportunistic infections if not chronically treated with antibiotics. The lack of B- and T-cell immunity resembles severe combined immunodeficiency (SCID) syndrome in human infants. SCID mice are useful as animal models since they are receptive to implantation of a human immune system producing SCID-human (SCID-hu) hematochimeric mice.
Adhesives used to fix prosthetic devices to bones and to cement bone to bone in difficult fractures. Synthetic resins are commonly used as cements. A mixture of monocalcium phosphate, monohydrate, alpha-tricalcium phosphate, and calcium carbonate with a sodium phosphate solution is also a useful bone paste.
Stem cells derived from HEMATOPOIETIC STEM CELLS. Derived from these myeloid progenitor cells are the MEGAKARYOCYTES; ERYTHROID CELLS; MYELOID CELLS; and some DENDRITIC CELLS.
The formation and development of blood cells outside the BONE MARROW, as in the SPLEEN; LIVER; or LYMPH NODES.
Mature osteoblasts that have become embedded in the BONE MATRIX. They occupy a small cavity, called lacuna, in the matrix and are connected to adjacent osteocytes via protoplasmic projections called canaliculi.
Leukemia associated with HYPERPLASIA of the lymphoid tissues and increased numbers of circulating malignant LYMPHOCYTES and lymphoblasts.
X-RAY COMPUTERIZED TOMOGRAPHY with resolution in the micrometer range.
The transfer of STEM CELLS from one individual to another within the same species (TRANSPLANTATION, HOMOLOGOUS) or between species (XENOTRANSPLANTATION), or transfer within the same individual (TRANSPLANTATION, AUTOLOGOUS). The source and location of the stem cells determines their potency or pluripotency to differentiate into various cell types.
Formation of MYELOID CELLS from the pluripotent HEMATOPOIETIC STEM CELLS in the BONE MARROW via MYELOID STEM CELLS. Myelopoiesis generally refers to the production of leukocytes in blood, such as MONOCYTES and GRANULOCYTES. This process also produces precursor cells for MACROPHAGE and DENDRITIC CELLS found in the lymphoid tissue.
Glycoprotein hormone, secreted chiefly by the KIDNEY in the adult and the LIVER in the FETUS, that acts on erythroid stem cells of the BONE MARROW to stimulate proliferation and differentiation.
Deliberate prevention or diminution of the host's immune response. It may be nonspecific as in the administration of immunosuppressive agents (drugs or radiation) or by lymphocyte depletion or may be specific as in desensitization or the simultaneous administration of antigen and immunosuppressive drugs.
A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.
Methods for maintaining or growing CELLS in vitro.
The use of two or more chemicals simultaneously or sequentially in the drug therapy of neoplasms. The drugs need not be in the same dosage form.
Resorption or wasting of the tooth-supporting bone (ALVEOLAR PROCESS) in the MAXILLA or MANDIBLE.
The number of PLATELETS per unit volume in a sample of venous BLOOD.
Family of RNA viruses that infects birds and mammals and encodes the enzyme reverse transcriptase. The family contains seven genera: DELTARETROVIRUS; LENTIVIRUS; RETROVIRUSES TYPE B, MAMMALIAN; ALPHARETROVIRUS; GAMMARETROVIRUS; RETROVIRUSES TYPE D; and SPUMAVIRUS. A key feature of retrovirus biology is the synthesis of a DNA copy of the genome which is integrated into cellular DNA. After integration it is sometimes not expressed but maintained in a latent state (PROVIRUSES).
A subnormal level of BLOOD PLATELETS.
Remnant of a tumor or cancer after primary, potentially curative therapy. (Dr. Daniel Masys, written communication)
An immunological attack mounted by a graft against the host because of tissue incompatibility when immunologically competent cells are transplanted to an immunologically incompetent host; the resulting clinical picture is that of GRAFT VS HOST DISEASE.
Blood of the fetus. Exchange of nutrients and waste between the fetal and maternal blood occurs via the PLACENTA. The cord blood is blood contained in the umbilical vessels (UMBILICAL CORD) at the time of delivery.
White blood cells. These include granular leukocytes (BASOPHILS; EOSINOPHILS; and NEUTROPHILS) as well as non-granular leukocytes (LYMPHOCYTES and MONOCYTES).
Established cell cultures that have the potential to propagate indefinitely.
Immature, nucleated ERYTHROCYTES occupying the stage of ERYTHROPOIESIS that follows formation of ERYTHROID PRECURSOR CELLS and precedes formation of RETICULOCYTES. The normal series is called normoblasts. Cells called MEGALOBLASTS are a pathologic series of erythroblasts.
Removal and pathologic examination of specimens in the form of small pieces of tissue from the living body.
The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION.
Mice bearing mutant genes which are phenotypically expressed in the animals.
The process of generating white blood cells (LEUKOCYTES) from the pluripotent HEMATOPOIETIC STEM CELLS of the BONE MARROW. There are two significant pathways to generate various types of leukocytes: MYELOPOIESIS, in which leukocytes in the blood are derived from MYELOID STEM CELLS, and LYMPHOPOIESIS, in which leukocytes of the lymphatic system (LYMPHOCYTES) are generated from lymphoid stem cells.
Non-antibody proteins secreted by inflammatory leukocytes and some non-leukocytic cells, that act as intercellular mediators. They differ from classical hormones in that they are produced by a number of tissue or cell types rather than by specialized glands. They generally act locally in a paracrine or autocrine rather than endocrine manner.
These growth factors comprise a family of hematopoietic regulators with biological specificities defined by their ability to support proliferation and differentiation of blood cells of different lineages. ERYTHROPOIETIN and the COLONY-STIMULATING FACTORS belong to this family. Some of these factors have been studied and used in the treatment of chemotherapy-induced neutropenia, myelodysplastic syndromes, and bone marrow failure syndromes.
Conditions which cause proliferation of hemopoietically active tissue or of tissue which has embryonic hemopoietic potential. They all involve dysregulation of multipotent MYELOID PROGENITOR CELLS, most often caused by a mutation in the JAK2 PROTEIN TYROSINE KINASE.
A class of statistical procedures for estimating the survival function (function of time, starting with a population 100% well at a given time and providing the percentage of the population still well at later times). The survival analysis is then used for making inferences about the effects of treatments, prognostic factors, exposures, and other covariates on the function.
Adherence of cells to surfaces or to other cells.
A humoral factor that stimulates the production of thrombocytes (BLOOD PLATELETS). Thrombopoietin stimulates the proliferation of bone marrow MEGAKARYOCYTES and their release of blood platelets. The process is called THROMBOPOIESIS.
A pyrimidine nucleoside analog that is used mainly in the treatment of leukemia, especially acute non-lymphoblastic leukemia. Cytarabine is an antimetabolite antineoplastic agent that inhibits the synthesis of DNA. Its actions are specific for the S phase of the cell cycle. It also has antiviral and immunosuppressant properties. (From Martindale, The Extra Pharmacopoeia, 30th ed, p472)
The SKELETON of the HEAD including the FACIAL BONES and the bones enclosing the BRAIN.
Antigens on surfaces of cells, including infectious or foreign cells or viruses. They are usually protein-containing groups on cell membranes or walls and may be isolated.
Group of rare congenital disorders characterized by impairment of both humoral and cell-mediated immunity, leukopenia, and low or absent antibody levels. It is inherited as an X-linked or autosomal recessive defect. Mutations occurring in many different genes cause human Severe Combined Immunodeficiency (SCID).
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control (induction or repression) of gene action at the level of transcription or translation.
Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
Lymphocyte progenitor cells that are restricted in their differentiation potential to the B lymphocyte lineage. The pro-B cell stage of B lymphocyte development precedes the pre-B cell stage.
A group of differentiation surface antigens, among the first to be discovered on thymocytes and T-lymphocytes. Originally identified in the mouse, they are also found in other species including humans, and are expressed on brain neurons and other cells.
Agents that suppress immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-CELLS or by inhibiting the activation of HELPER CELLS. While immunosuppression has been brought about in the past primarily to prevent rejection of transplanted organs, new applications involving mediation of the effects of INTERLEUKINS and other CYTOKINES are emerging.
Granular leukocytes having a nucleus with three to five lobes connected by slender threads of chromatin, and cytoplasm containing fine inconspicuous granules and stainable by neutral dyes.
Antigens expressed primarily on the membranes of living cells during sequential stages of maturation and differentiation. As immunologic markers they have high organ and tissue specificity and are useful as probes in studies of normal cell development as well as neoplastic transformation.
The classes of BONE MARROW-derived blood cells in the monocytic series (MONOCYTES and their precursors) and granulocytic series (GRANULOCYTES and their precursors).
One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.
Large, phagocytic mononuclear leukocytes produced in the vertebrate BONE MARROW and released into the BLOOD; contain a large, oval or somewhat indented nucleus surrounded by voluminous cytoplasm and numerous organelles.
A bone morphogenetic protein that is widely expressed during EMBRYONIC DEVELOPMENT. It is both a potent osteogenic factor and a specific regulator of nephrogenesis.
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
The physiological renewal, repair, or replacement of tissue.
Specialized stem cells that are committed to give rise to cells that have a particular function; examples are MYOBLASTS; MYELOID PROGENITOR CELLS; and skin stem cells. (Stem Cells: A Primer [Internet]. Bethesda (MD): National Institutes of Health (US); 2000 May [cited 2002 Apr 5]. Available from: http://www.nih.gov/news/stemcell/primer.htm)
Mapping of the KARYOTYPE of a cell.
Congenital disorder affecting all bone marrow elements, resulting in ANEMIA; LEUKOPENIA; and THROMBOPENIA, and associated with cardiac, renal, and limb malformations as well as dermal pigmentary changes. Spontaneous CHROMOSOME BREAKAGE is a feature of this disease along with predisposition to LEUKEMIA. There are at least 7 complementation groups in Fanconi anemia: FANCA, FANCB, FANCC, FANCD1, FANCD2, FANCE, FANCF, FANCG, and FANCL. (from Online Mendelian Inheritance in Man, http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=227650, August 20, 2004)
A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.
The relationship between the dose of an administered drug and the response of the organism to the drug.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Excessive formation of dense trabecular bone leading to pathological fractures; OSTEITIS; SPLENOMEGALY with infarct; ANEMIA; and extramedullary hemopoiesis (HEMATOPOIESIS, EXTRAMEDULLARY).
Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.
A mononuclear phagocyte colony-stimulating factor (M-CSF) synthesized by mesenchymal cells. The compound stimulates the survival, proliferation, and differentiation of hematopoietic cells of the monocyte-macrophage series. M-CSF is a disulfide-bonded glycoprotein dimer with a MW of 70 kDa. It binds to a specific high affinity receptor (RECEPTOR, MACROPHAGE COLONY-STIMULATING FACTOR).
They are oval or bean shaped bodies (1 - 30 mm in diameter) located along the lymphatic system.
Death resulting from the presence of a disease in an individual, as shown by a single case report or a limited number of patients. This should be differentiated from DEATH, the physiological cessation of life and from MORTALITY, an epidemiological or statistical concept.
A classification of B-lymphocytes based on structurally or functionally different populations of cells.
Conditions in which the abnormalities in the peripheral blood or bone marrow represent the early manifestations of acute leukemia, but in which the changes are not of sufficient magnitude or specificity to permit a diagnosis of acute leukemia by the usual clinical criteria.
Protein analogs and derivatives of the Aequorea victoria green fluorescent protein that emit light (FLUORESCENCE) when excited with ULTRAVIOLET RAYS. They are used in REPORTER GENES in doing GENETIC TECHNIQUES. Numerous mutants have been made to emit other colors or be sensitive to pH.
CXCR receptors with specificity for CXCL12 CHEMOKINE. The receptors may play a role in HEMATOPOIESIS regulation and can also function as coreceptors for the HUMAN IMMUNODEFICIENCY VIRUS.
Bone marrow aspirates will display hypercellularity with increased counts of granulocytic and monocytic cells. Bone marrow core ... 1.5x109/L. Presence of two or more phenotypical abnormalities can aid a diagnosis of CMML in the absence of identifying ... which are cancers of the blood-forming cells of the bone marrow. In adults, blood cells are formed in the bone marrow, by a ... The FAB criteria for diagnosis are as follows: Monocyte count >1x109/L 0-19% blasts in bone marrow 1x109/L No Philadelphia ...
Their presence in tissues such as bone marrow suggests drowning; however, they are present in soil and the atmosphere, and ... The presence of these diatoms may be diagnostic of drowning. Of people who have survived drowning, almost one-third will ... Drowning can occur anywhere there is water, even in the presence of lifeguards. Risk can vary with location depending on age. ... on the chest bone (approximately on the lower part). Attempts to actively expel water from the airway by abdominal thrusts, ...
The presence of ALIPs is associated with worse prognosis of MDS . Recently, in bone marrow sections of patients with acute ... Yu Y (Jan 2014). "Clustered precursors in bone marrow sections predict early relapse in patients with acute myeloid leukemia ... Tricot G (Oct 1984). "Bone marrow histology in myelodysplastic syndromes. II. Prognostic value of abnormal localization of ... on bone marrow biopsy. In healthy humans, precursors are rare and are found localized near the endosteum, and consist of 1-2 ...
A bone marrow test confirms the presence of leukemia cancer cells. Alex's parents decide not to pursue any more medical actions ... She was recently diagnosed with leukemia after a bone marrow aspirate procedure confirmed the presence of the disease. Her ... A biopsy, bone marrow tests, and several scans are performed which confirm that the cancer cells do indeed remain in his neck. ... and multiple bone marrow transplants. At the moment of her introduction, she is in remission. Her mother, Judy Lougheed, ...
During maturation in the bone marrow, late erythroblasts normally expel their nuclei; but, in some cases, a small portion of ... Its presence usually signifies a damaged or absent spleen, because a healthy spleen would normally filter this type of red ...
... or bone marrow, or with the presence of mast cells in the blood X-rays, ultrasound, or lymph node, bone marrow, or organ ... Mast cells originate from the bone marrow and are normally found throughout the connective tissue of the body as normal ... When metastasis does occur, it is usually to the liver, spleen, lymph nodes and bone marrow. When mastocytomas affect humans, ... The presence of these signs usually indicates mastocytosis, which is the spread of mast cells throughout the body. Release of a ...
... s develop [mature] in the thymus, and B cells, in mammals, develop [mature] in the bone marrow in adults or the liver in ... These are named for the presence of the cell surface proteins CD8 or CD4.) CD8+ T cells, also known as "killer T cells", are ... T cells are born from hematopoietic stem cells, found in the bone marrow. Then, developing T cells migrate to the thymus gland ... All T cells originate from c-kit+Sca1+ haematopoietic stem cells (HSC) which reside in the bone marrow. In some cases, the ...
In mice (given 20 mg nivalenol /kg bw orally or 3.7 mg /kg bw ip) the DNA of kidney, bone marrow, stomach, jejunum and colon ... "Scientific Opinion on risks for animal and public health related to the presence of nivalenol in food and feed". European Food ... Acute toxicity of nivalenol induces bone marrow toxicity and toxicity of lymphoid organs. Long-term exposure may result in ... bone marrow, lymph node, brain and small intestines with or without Peyer's patch". The lowest doses (0.7 mg nivalenol /kg bw) ...
The incidence varies by the type of transplantation: the lowest rates are seen with bone marrow transplants and liver ... The presence of respiratory symptoms, such as cough or shortness of breath, in the setting of immunosuppression may suggest ... Transplantation of unmatched or mismatched HLA bone marrow also increase the risk of PTLD.[citation needed] The main risk ... factors for PTLD are the degree of immune suppression and the presence of Epstein-Barr virus. Specifically, higher levels of T ...
A null cell is a large granular lymphocyte that develops inside the bone marrow. Null cells lack the common characteristic ... They are rapidly stimulated in the presence of pathogens like viruses and attack viral-infected or tumor cells in a non MHC- ...
It suppresses the bone marrow by inhibiting the erythroid progenitor cells. Anti-M also recommends antigen testing to rule out ... In the presence of significant hemolysis the smear will show schistocytes (fragmented red blood cells), reticulocytosis, and in ... and hematocrit due to red blood cell destruction Reticulocyte count which will usually be increased as the bone marrow makes ... Infants with Anti-M are also recommended to receive antigen testing to rule out the presence of HDN. The below tests are often ...
... bone marrow biopsy to determine bone marrow involvement, and PET/CT imaging of the chest, abdomen, pelvis, and any areas ... presence of localized bone lesions; kidney involvement; reduced levels of circulating blood platelets or any of the various ... stem cell bone marrow transplantation. While studies are inconclusive, autologous stem cell bone marrow transplantation appears ... This translocation is proposed to occur during the early development of immature bone marrow B-cells (i.e. pre-B-cells/pro-B- ...
Bone marrow was used as a source to develop a DNA Profile. It was announced in February 2019 that the remains were identified ... would like to speak to anyone who knew Boothe-Wilson in the Marines or the circumstances of her presence in Jacksonville. Her ...
Bone marrow aspirate in both conditions may show dysplasia of blood cell precursors and the presence of ring sideroblasts ( ... The peripheral blood and bone marrow aspirate findings in copper deficiency can mimic myelodysplastic syndrome. ... the bone marrow aspirate in copper deficiency characteristically shows cytoplasmic vacuoles within red and white cell ... copper serum test and bone marrow biopsy are usually conclusive in diagnosing copper deficiency). On average, patients are ...
Recently they have been shown to reside for much longer periods in the bone marrow as long-lived plasma cells (LLPC). They ... plasma cells will likely secrete IgG3 antibodies if they matured in the presence of the cytokine interferon-gamma. Since B cell ... After leaving the bone marrow, the B cell acts as an antigen presenting cell (APC) and internalizes offending antigens, which ... Plasma cells originate in the bone marrow; B cells differentiate into plasma cells that produce antibody molecules closely ...
... and diminished erythroid precursors in bone marrow. Features that support a diagnosis of DBA include the presence of congenital ... "Unexpected complications after bone marrow transplantation in transfusion-dependent children". Bone Marrow Transplantation. 12 ... Typically, a diagnosis of DBA is made through a blood count and a bone marrow biopsy. A diagnosis of DBA is made on the basis ... Bone marrow transplantation (BMT) can cure hematological aspects of DBA. This option may be considered when patients become ...
Erythrocytes mature through erythropoiesis in the bone marrow, where they lose their nuclei, organelles, and ribosomes. The ... For example, the presence of small intranuclear rods has been reported in some cases of nemaline myopathy. This condition ... The presence of mutagens may induce the release of some immature "micronucleated" erythrocytes into the bloodstream. Anucleated ... Other multinucleate cells in the human are osteoclasts a type of bone cell. Multinucleated and binucleated cells can also be ...
Biopsies of skin lesions, lymph nodes, and bone marrow demonstrate the presence of organisms on histopathology. Extracellular ... Non-specific laboratory findings may show evidence of the fungus invading tissue, such as thrombocytopenia due to bone marrow ...
In 1998, she died of complications following a bone marrow transplant at the age of 51. One of the leading contemporary Italian ... coloratura mezzos, she had a rich, creamy and agile voice used with fine musicianship, and had a good stage presence. Her ...
... requiring the extraction of bone marrow samples from the hip bone to determine the presence of lymphoma cells in bone marrow. ... Bone marrow biopsy is used to show the extent of disease, known as staging in pathology. The process takes about 10-15 minutes ... "Lymphoma Action , Bone marrow biopsy". Lymphoma Action. Retrieved 2020-04-26. "Understanding Mature T-Cell Lymphoma - Fact ... High dosage of chemotherapy may damage the bone marrow, in which autologous stem cell therapy is a recommended follow-up ...
On bone marrow aspiration or biopsy, megaloblasts are seen.[citation needed] The Schilling test was a radio-isotope method, now ... The presence of peripheral sensory-motor symptoms or subacute combined degeneration of spinal cord strongly suggests the ... Tissue deficiency resulting in negative effects in nerve cells, bone marrow, and the skin. The main type of vitamin B 12 ... It is characterized by a triad of symptoms: Anemia with bone marrow promegaloblastosis (megaloblastic anemia). This is due to ...
An 8-month-old bone marrow transplant patient died of VA1/HMO-C encephalitis following the transplant. The presence of VA1/HMO- ... Presence of viral particles in fecal matter and in epithelial intestinal cells indicate that the virus replicates in the ... completes an epidemiological study on the presence of astrovirus in Barcelona, Spain; the total incidence of astrovirus in ... sequence astrovirus RNA and determine the presence of three ORFs and ribosomal frameshifting 1993: Monroe et al. classify ...
Autologous stem cell bone marrow transplantation has not improved the results of these regiments. Treatment of HIV-associated ... Navari M, Etebari M, De Falco G, Ambrosio MR, Gibellini D, Leoncini L, Piccaluga PP (2015). "The presence of Epstein-Barr virus ... Erythrophagocytosis (i.e. ingestion of red blood cells by histiocytes) often occurs in the bone marrow, spleen, and/or liver. ... All cases had EPV+ lymphocytes in bone marrow and tissue infiltrates; occasional cases had also has circulating EBV+ ...
This generally reflects early or premature release of myeloid cells from the bone marrow, the site where neutrophils are ... A "left shift" refers to the presence of increased proportions of younger, less well differentiated neutrophils and neutrophil- ...
However, MBP-related transcripts are also present in the bone marrow and the immune system. These mRNAs arise from the long MBP ... These forms differ by the presence or the absence of short (10 to 20 residues) peptides in various internal locations in the ...
The presence of red bone marrow is rare in members of Chaetophractus, but widespread in Dasypus novemcinctus osteoderms. These ... The presence of a carapace containing osteoderms is one of the very distinctive features of armadillos, and is true for fossil ... The outer and inner parts are made of thin, compact bone, while the middle zone is thicker and contains tissues for hair ... Not much is known about the cranial morphology of these species, especially bone descriptions. More research is being done to ...
... marked by presence in the blood. For this reason, both the peripheral blood and bone marrow are evaluated for the presence of ... Bone marrow, liver and gastrointestinal tract involvement occurs relatively early in the course of the disease. Mantle cell ... MCL may also replace normal cells in the bone marrow, which impairs normal blood cell production. Diagnosis generally requires ... Mantle cell lymphoma is a systemic disease with frequent involvement of the bone marrow and gastrointestinal tract (generally ...
... bone marrow examination for the presence of malignant B-cells. PT-LBCL had been treated principally with the CHOP regimen used ... with examination of the cerebral spinal fluid obtained from spinal taps for the presence of malignant B-cells; and in cases ...
Bone Marrow Transplant Retrieved on 21 November 2008 Srivastava A, Bapat M, Ranade S, Srinivasan V, Murugan P, Manjunath S, ... The presence of stem cells in the mature primate brain was first reported in 1967. It has since been shown that new neurons are ... Endothelial stem cells are one of the three types of multipotent stem cells found in the bone marrow. They are a rare and ... Stem cells from the bone marrow, which is derived from mesoderm, can differentiate into liver, lung, GI tract and skin, which ...
... implications for bone marrow metastasis". Proceedings of the National Academy of Sciences of the United States of America. 97 ( ... in the presence of a stressor. Unique among biological processes, SP release (and expression of its NK1 Receptor (through ...
Bone marrow transplant may be possible for Severe Combined Immune Deficiency and other severe immunodeficiences. Virus-specific ... Some are latent, and require a certain environmental trigger to become manifest, like the presence in the environment of a ... June 2008). "Stem cell transplantation for primary immunodeficiencies". Bone Marrow Transplant. 41 Suppl 2: S83-6. doi:10.1038/ ... For instance, an antibody deficiency can be diagnosed in the presence of low immunoglobulins, recurrent infections and failure ...
This agent also causes respiratory tract lesions, bone marrow depression, and eye damage, the epithelial tissues of these ... Smoke inhalation injury, either by itself but more so in the presence of body surface burn, can result in severe lung-induced ...
For a long time, the most efficient approach had been to use bone marrow graft, or hematopoietic stem cell transplantation. ... The presence or absence of the skin lesions is not helpful, however, in predicting clinical severity in Hunter syndrome. ... Because of all these reasons, bone marrow grafts or hematopoietic stem cell transplantation have seen a decrease in their ... The bones themselves may be affected, resulting in short stature. In addition, pebbly, ivory-colored skin lesions may be found ...
"Effect of homologous bone marrow injections in x-irradiated rabbits". British Journal of Experimental Pathology. 38 (4): 401- ... It can also be a substance whose detection indicates a particular disease state, for example, the presence of an antibody may ...
The bone marrow of a normal healthy adult produces more than 100 billion neutrophils per day, and more than 10 times that many ... Lack of blood vessels, the inability of the epidermis to retain moisture, and the presence of sebaceous glands in the dermis, ... but are the products of multipotent hematopoietic stem cells present in the bone marrow.[7] ... are known as granulocytes due to the presence of granules in their cytoplasm, or as polymorphonuclear cells (PMNs) due to their ...
In experiments, it new bone fully covered skull wounds in test animals and stimulated growth in human bone marrow stromal cells ... that the addition of Wortmannin can significantly increase the response of cells into an osteogenic lineage in the presence of ... A non-viral PDGF "bio patch" can regenerate missing or damaged bone by delivering DNA in a nano-sized particle directly into ... Repairing bone fractures, fixing craniofacial defects and improving dental implants are among potential uses. The patch employs ...
Møller M; El Maghrabi R; Olesen N; Thomsen VØ (November 2004). "Safe inoculation of blood and bone marrow for liquid culture ... Tissue or fluid samples are tested for the presence of a specific pathogen, which is determined by growth in a selective or ... such as the patient's likelihood of exposure to the suspected organism and the presence and prevalence of a microbial strain in ... although the clinical aspect of the field primarily focuses on the presence and growth of microbial infections in individuals, ...
He returned to London, where he was diagnosed with an inoperable prostate cancer, which had spread to his bone marrow. He spent ... De Valera hoped Wittgenstein's presence would contribute to the Dublin Institute for Advanced Studies which he was soon to set ... One knew that one was in the presence of extreme seriousness, absorption, and force of intellect... Wittgenstein was a ...
Another product is iron, which is used in the formation of new blood cells in the bone marrow.[5] Medicine treats the spleen ... The presence of salivary lipase is of prime importance in young babies whose pancreatic lipase has yet to be developed.[14] ... They are made of a bone-like material called dentin, which is covered by the hardest tissue in the body-enamel.[8] Teeth have ... The palate is hard at the front of the mouth since the overlying mucosa is covering a plate of bone; it is softer and more ...
... inflammatory responses within the bone marrow are believed to foster many hematological diseases. The secretion of IL-6 by bone ... marrow stromal cells (BMSC) and the secretion of the adhesion molecules VCAM-1, ICAM-1 and LFA, is induced in the presence of ... July 1994). "Bone marrow angiogenesis and progression in multiple myeloma". Br. J. Haematol. 87 (3): 503-8. doi:10.1111/j.1365- ... They discovered increased bone marrow angiogenesis correlates with myeloma growth and supporting stromal cells are a ...
Adult stem cells like bone marrow stem cells have also shown a potential to differentiate into cardiac competent cells when ... This is due to the presence of genomic imprinting in the region. Beckwith-Wiedemann syndrome is also associated with genomic ... "The histone methyltransferase inhibitor BIX01294 enhances the cardiac potential of bone marrow cells.". Stem Cells Dev. 22: 654 ... "Inhibition of G9a Histone Methyltransferase Converts Bone Marrow Mesenchymal Stem Cells to Cardiac Competent Progenitors.". ...
They did the first UK clinical trials of the rubella vaccine, and the first bone marrow transplant and gene therapy for severe ... Ltd, Presence Multimedia. "Headline Pictures » Headline Pictures secures film and TV rights to PETER PAN IN SCARLET". www. ...
Hargraves M, Richmond H, Morton R. Presentation of two bone marrow components, the tart cell and the LE cell. Mayo Clin Proc ... The presence of anti-dsDNA antibodies is also linked with lupus nephritis and there is evidence they are the cause. Some anti- ... The LE cell was discovered in bone marrow in 1948 by Hargraves et al.[69] In 1957 Holborow et al. first demonstrated ANA using ... The presence of ANAs in blood can be confirmed by a screening test. Although there are many tests for the detection of ANAs, ...
Other common causes of low hemoglobin include loss of blood, nutritional deficiency, bone marrow problems, chemotherapy, kidney ... Presence in nonerythroid cells[edit]. Some nonerythroid cells (i.e., cells other than the red blood cell line) contain ... of Hb continues in the cell throughout its early development from the proerythroblast to the reticulocyte in the bone marrow. ... The specific enzyme protected is nitrogenase, which is unable to reduce nitrogen gas in the presence of free oxygen.. ...
Through this process red blood cells are continuously produced in the red bone marrow of large bones. (In the embryo, the liver ... The presence of specialized structures named "lipid rafts" in the red blood cell membrane have been described by recent studies ... They are also recycled in the bone marrow.[46]. Senescence. The aging red blood cell undergoes changes in its plasma membrane, ... Approximately 2.4 million new erythrocytes are produced per second in human adults.[3] The cells develop in the bone marrow and ...
Basophils are one of the least abundant cells in bone marrow and blood (occurring at less than two percent of all cells). Like ... Granulocytes are a category of white blood cells characterized by the presence of granules in their cytoplasm.[1] They are also ... When an infection occurs, mature basophils will be released from the bone marrow and travel to the site of infection.[22] When ... Granulocytes are derived from stem cells residing in the bone marrow. The differentiation of these stem cells from pluripotent ...
... subtype selective adenosine receptor agonists during proliferation and osteogenic differentiation of human primary bone marrow ... This integral membrane protein stimulates adenylate cyclase activity in the presence of adenosine. This protein also interacts ... Bone homeostasis[edit]. Adenosine receptors play a key role in the homeostasis of bone. The A1 receptor has been shown to ... Regulate Bone Resorption II Adenosine A1R Blockade or Deletion Increases Bone Density and Prevents Ovariectomy-Induced Bone ...
Bone pain, joint pain (caused by the spread of "blast" cells to the surface of the bone or into the joint from the marrow ... Due to presence of CNS involvement in 10-40% of adult with ALL at diagnosis, most providers start Central nervous system (CNS) ... A bone marrow biopsy provides conclusive proof of ALL, typically with ,20% of all cells being leukemic lymphoblasts.[27] A ... These lymphoblasts build up in the bone marrow and may spread to other sites in the body, such as lymph nodes, the mediastinum ...
... a spongy layer of red bone marrow in the middle, and the compact layer of the inner table (Lamina interna).[25] ... The presence of a concussion or skull fracture in people after trauma without intracranial hemorrhage or focal neurologic ... one frontal bone, two parietal bones, two temporal bones, one occipital bone, one sphenoid bone, and one ethmoid bone.[24] ... The bones of the skull are in three layers: the hard compact layer of the external table (lamina externa), the diploë ( ...
Normally lymphoblasts are found in the bone marrow, but in acute lymphoblastic leukemia (ALL), lymphoblasts proliferate ... these morphologic distinctions are not absolute and a definitive diagnoses relies on antibody immunostaining for the presence ...
Thymus and Bone Marrow) or the peripheral lymphoid organs (lymph node, spleen, etc., where self-reactive B-cells may be ... In the presence of chronic and inflammatory cell damage, the adaptive immune system is recruited and self-tolerance is lost ... Presence of multiple uncleared viral infections due to lack of perforin are thought to be responsible. ... This may relate to abnormal citrullination of proteins, since the effects of smoking correlate with the presence of antibodies ...
A bone marrow biopsy will reveal collagen fibrosis, replacing the marrow that would normally occupy the space.[citation needed] ... However, splenectomy in the presence of massive splenomegaly is a high-risk procedure, with a mortality risk as high as 3% in ... Primary myelofibrosis (PMF) is a rare bone marrow blood cancer.[1] It is classified by the World Health Organization (WHO) as a ... The bone marrow in a typical case is hypercellular and diffusely fibrotic. Both early and late in disease, megakaryocytes are ...
Bone Marrow Transplantation for Breast Cancer: Bone Marrow Transplantation for Breast Cancer. Oxford University Press. p. 183. ... Plausible confounding would change the effect: This is when despite the presence of a possible confounding factor which is ...
Krumbhaar EB (1919). "Role of the blood and the bone marrow in certain forms of gas poisoning". JAMA. 72: 39-41. doi:10.1001/ ... There are a few possible causes of resistance in cancer, one of which is the presence of small pumps on the surface of cancer ... In very severe myelosuppression, which occurs in some regimens, almost all the bone marrow stem cells (cells that produce white ... Virtually all chemotherapeutic regimens can cause depression of the immune system, often by paralysing the bone marrow and ...
... created a bone marrow registry, the Tzu Chi Bone Marrow Bank, in 1993 after a young follower of Cheng Yen was diagnosed ... the network grew into a global broadcasting presence with offerings of a radio service,[82] Tzu Chi Channel 1, Tzu Chi Channel ... the foundation created a bone marrow registry, an effort that eventually caused Taiwan to alter its bone marrow laws, and ... Tzu Chi had registered more than 307,657 bone marrow donors.[45]. College of MedicineEdit. Tzu Chi established the Tzu Chi ...
Urine cytology evaluates this urinary sediment for the presence of cancerous cells from the lining of the urinary tract, and it ...
Osteoporotic bone marrow defect. *Paget's disease of bone. *Periapical abscess *Phoenix abscess ... Presence of associated symptoms (eg, pain, burning). *Medication the patients are taking within the few weeks to months after ... This morphology is characterized by the presence of a few well-demarcated, white-bluish papules or plaques with central ... Further on, Darier explained the presence of such characteristic markings by correlating with an increase thickness of the ...
... Bibliographie ... OBJECTIVE: In previous work, we showed that CD34+ bone marrow cells can be successfully expanded along the myeloid pathway in ... In B-cell cultures, the expanded cells were maintained over MS5 in the presence of Flt3-l for 4-8 weeks. RESULTS: NK cells rose ... In NK proliferation assays, the cells were maintained over stroma cells in the presence of IL-2 for 4-5 weeks. NK initiating ...
In the presence of bone marrow stromal cells human multiple myeloma cells become independent of the IL-6/gp 130/STAT3 pathway ... pathway is not essential for survival of human myeloma cells if they are grown in the presence of cells from the bone marrow ... induced apoptosis if the cells were cultured in the absence of bone marrow stromal cells (BMSCs). In contrast, apoptosis could ... signaling pathways were obtained from experiments performed with MM cell lines and without considering the bone marrow ...
Immunotherapy with Donor Bone Marrow Supports Facial Allograft Survival by Presence of Regulatory CD4+/CD25+ T-Cell. Aleksandra ... In this study we tested the effect of donor bone marrow transplantation (DBMT) under short-term alpha-betaTCRmAb and CsA 7-day ... Additionally Groups 5 and 6 were augmented with intraosseous DBMT of 35x106, and 100x106 of bone marrow cells (BMC) ... antigens and presence of regulatory T-cells (Treg) CD4+/CD25+. Histological grading of graft rejection was assessed by H+E ...
Enhanced osteogenesis of bone marrow stem cells cultured on hydroxyapatite/collagen I scaffold in the presence of low-frequency ...
... mouse or human bone marrow cells. This culture technique will allow a detailed analysis of both ovine colony-stimulating ... neutrophil/monocyte and mixed phenotype colonies developed in stimulated bone marrow cultures in a conditioned medium dose- ... Techniques for the development of ovine bone marrow-derived haemopoietic progenitor cells and in situ identification of colony ... Ovine haemopoiesis: the development of bone marrow-derived colony-forming cells in vitro in the presence of factors derived ...
Presence of disseminated tumor cells (DTCs) in bone marrow (BM) as an independent prognostic factor for breast cancer patients ... 160-171 available at www.sciencedirect.com www.elsevier.com/locate/molonc Presence of bone marrow micrometastasis is associated ... Preparation of the bone marrow and immunocytochemical staining A total of 40 ml BM was aspirated from anterior and posterior ... Cytokeratin-positive cells in the bone marrow and survival of patients with stage I, II, or III breast cancer. N. Engl. J. Med ...
MKs + in bone marrow ,/li,,/ul,,ul,,li,WAS  presence of microthrombocytes. MKs + in bone marrow ,/li,,/ul,,ul,,li,Acquired ... li,,/ul,,/ul,,ul,,ul,,li,Bone Marrow not very helpful as initial test ,/li,,/ul,,/ul,,ul,,ul,,ul,,li,Helpful in patient over 50 ... Splenectomy and/or bone marrow transplantation in the management of the Wiskott-Aldrich syndrome: long-term follow-up of 62 ... li,,/ul,,/ul,,/ul,,/ul,,ul,,ul,,li,Bone Marrow Suppression by HCV ,/li,,/ul,,/ul,,ul,,ul,,li,Immune Dysfunction ,/li,,/ul,,/ul ...
Read chapter 20 The Validity of Blood and Urinary Cytokine Measurements for Detecting the Presence of Inflammation: The latest ... NOTE: PHA, phytohemagglutinin; PWM, pokeweed mitogen; BM, bone marrow.. * Values above the upper limit of normality are shown ... Studies in leukemia patients following bone marrow transplant have demonstrated that patients with normal immunoglobulin levels ... 20 The Validity of Blood and Urinary Cytokine Measurements for Detecting the Presence of Inflammation 431-450 ...
Presence of a uterus. *Fall into one of the following categories:. *Healthy volunteers ... Bone Marrow Cell Engraftment of the Uterus and Genetic Studies of Reproductive Functioning. The safety and scientific validity ... Therefore, the subtype of cells from the bone marrow responsible for engraftment is not yet known, nor is the ideal ... Interestingly, women who have had bone marrow transplants have been found to have donor tissue in their endometrium, which ...
Bone Marrow Transplantation 50 , 348-353 Rights & permissionsfor article Presence of CD34,sup,+,/sup,CD38,sup,−,/sup,CD58,sup ... Bone Marrow Transplantation 50 , 601-603 Rights & permissionsfor article A retrospective comparison of BU-fludarabine and BU-CY ... Bone Marrow Transplantation 49 , 426-433 Rights & permissionsfor article Influence of two different doses of antithymocyte ... Bone Marrow Transplantation 50 , 20-25 Rights & permissionsfor article Haploidentical hematopoietic SCT may be superior to ...
Bone Marrow Transplantation 50 , 348-353 Rights & permissionsfor article Presence of CD34,sup,+,/sup,CD38,sup,−,/sup,CD58,sup ... Bone Marrow Transplantation 51 , 249-255 Rights & permissionsfor article The bone marrow microenvironment is similarly impaired ... The bone marrow microenvironment is similarly impaired in allogeneic hematopoietic stem cell transplantation patients with ... Discrepancies between the percentage of plasma cells in bone marrow aspiration and BM biopsy: Impact on the revised IMWG ...
Documentation in bone-marrow-augmented organ recipients of the presence of dendritic cell progenitors of donor origin ... Documentation in bone-marrow-augmented organ recipients of the presence of dendritic cell progenitors of donor origin. ...
In contrast to the murine system, long-term hamster bone marrow suspension cultures maintain proliferation of both pluripotent ... Presence of mixed colony-forming cells in long-term hamster bone marrow suspension cultures: response to pokeweed spleen ... Presence of mixed colony-forming cells in long-term hamster bone marrow suspension cultures: response to pokeweed spleen ... In contrast to the murine system, long-term hamster bone marrow suspension cultures maintain proliferation of both pluripotent ...
To figure out if IL-6 is a element implicated in the ex vivo bone marrow amplification noticed in the existence of PTH and Flt- ... To determine if IL-6 is a factor implicated in the ex vivo bone marrow amplification observed in the presence of PTH and Flt-3L ... Complete bone marrow was isolated from wild-kind mice and seeded at 1.86105 cells/cm2 in the existence or absence of Flt-3L (a ... Bone marrow was isolated and flow cytometric analyses of Annexin V+ cells ended up done. Graph of the share of Annexin V+ cells ...
Donating bone marrow is anonymous, so Ryals and Skye didnt meet. But from that surgery in 2016, the two were linked. ... 3-year-old cancer survivor serves as a flower girl in her bone marrow donors wedding. Posted 8:29 am, July 3, 2018, by CNN ... Ryals, 26, signed up to be a bone marrow donor in college. She had just changed her major, and she wasnt sure what she wanted ... But after chemotherapy and more bone marrow transplants, she pulled through.. "Shes a fighter, and she is full of spunk, and ...
In MG63 and hBMS cells T(3) treatment increased luciferase activity 5.5 +/- 0.7-fold (P , 0.05), confirming the presence of ... derived from explants of trabecular bone, in human bone marrow stromal cells (hBMS), which are believed to be the source of ... TR expression and function in human bone marrow stromal and osteoblast-like cells.. Siddiqi A1, Parsons MP, Lewis JL, Monson JP ... Thyroid hormones influence both bone formation and bone resorption. In vitro studies demonstrate direct effects of thyroid ...
Presence of significant extrahepatic biliary disease (e.g. CBD stone, PSC, etc.) ... Autologous Bone Marrow Stem Cells in Cirrhosis Patients. The safety and scientific validity of this study is the responsibility ... Autologous Transplantation of Bone Marrow Derived CD 133 Positive Stem Cell and Mono Nuclear Cell (MNC) Transplantation in ... In this study we will evaluate safety and feasibility of autologous bone marrow mono nuclear (BM-MNC) and enriched CD133+ ...
The goal of BMT is to transfuse healthy bone marrow cells when unhealthy bone marrow has been eliminated. ... Bone marrow transplantation (BMT) is a special therapy for patients with certain cancers or other diseases. ... The blood is then tested for type and the presence of viruses or disease, and the stem cells are counted. The cord blood is ... What is bone marrow?. The bone marrow is a soft, spongy tissue found inside the bones. The bone marrow in the hips, breast bone ...
Newer methods of treatment include bone marrow or stem cell transplantation and monoclonal antibodies (antibodies produced by ... The presence of EBV in patients with endemic Burkitts has been interpreted as a side effect of the high rates of malaria in ... In adults, Burkitts lymphoma frequently produces a bulky abdomen and may involve the liver, spleen, and bone marrow. ... Should I consider bone marrow transplant or monoclonal antibodies as treatment options? ...
The presence of Howell-Jolly bodies (a type of granule) may indicate:. *Bone marrow does not produce enough healthy blood cells ... Cancer in the bone marrow. *Anemia caused by bone marrow not producing normal blood cells due to toxins or tumor cells ( ... Disorder of the bone marrow in which the marrow is replaced by fibrous scar tissue (myelofibrosis) ... Disorder of the bone marrow in which the marrow is replaced by fibrous scar tissue (myelofibrosis) ...
Procedure: Bone marrow transplantation During kidney transplant, bone marrow cells donated by the same donor as the kidney are ... Experimental: Kidney and Marrow Recipients Combined kidney and bone marrow transplant. Procedure: Kidney Transplantation ... Combined Kidney and Bone Marrow Transplantation to Prevent Kidney Transplant Rejection. The safety and scientific validity of ... Eligible donors will be admitted to the hospital for 3-5 days, where bone marrow will be collected prior to removal of the ...
Bone marrow appeared active with presence of three lineages. We noted no features of hypoplastic marrow or reactive ... We found no features of bone marrow failure or reactive haemophagocytic syndrome. The inflammatory exudates in the lungs showed ... Viral isolation, in particular for coronavirus, showed negative results in the splenic, lymph node, and bone marrow tissues. ... The postmortem findings of active bone marrow with normal megakaryoctes in patients with thrombocytopenia favour an immune ...
In a study published March 2, scientists in Germany and the United States propose rejuvenating the bone marrow niche where HSCs ... Now researchers are reporting in the scientific journal EMBO that the bone marrow niche where HSCs form also ages, ... This includes the presence of smaller numbers of HSCs with greater potential for forming different types of blood cells, which ... which help form bone. Osteoblasts make a protein called osteopontin, which is important to supporting a vibrant bone marrow ...
The presence of 2 colors indicates coexpression. Grey indicates TPM ,1 for all 4 factors. For D, color indicates membership in ... An inherited preleukemic bone marrow failure disorder with aberrant hematopoietic progenitors and faulty marrow ... TGF-β signaling underlies hematopoietic dysfunction and bone marrow failure in Shwachman-Diamond syndrome. Cailin E. Joyce,1,2 ... TGF-β inhibition rescues hematopoietic stem cell defects and bone marrow failure in Fanconi anemia. Cell Stem Cell. 2016;18(5): ...
Bone marrow and/or blood cells are collected, prepared and stained. Preparations are analyzed for the presence of micronuclei. ... 475: Mammalian Bone Marrow Chromosomal Aberration Test The mammalian in vivo chromosome aberration test is used for the ... Chromosome preparations are then made from the bone marrow cells and stained, and metaphase cells are analysed for chromosome ... by analysis of erythrocytes as sampled in bone marrow and/or peripheral blood cells of animals, usually rodents (mice or rats). ...
... abnormal and immature red blood cells called as megaloblasts in the bone marrow. ... Bone Marrow Biopsy: Enlarged and immature red blood cells are found in bone marrow and they confirm the diagnosis. ... Peripheral Blood Smear: Examination of a peripheral blood smear show the presence of enlarged, irregular and abnormally shaped ... abnormal and immature red blood cells called as megaloblasts by the bone marrow, which are released into the blood. ...
Detailed information on bone marrow transplant, including preparation, types of transplant, transplant team, and possible ... Presence of severe complications. The following are complications that may happen with a bone marrow transplant. However, each ... Bone Marrow Transplantation. What is a bone marrow transplant?. Bone marrow transplant (BMT) is a special therapy for patients ... A bone marrow transplant can be used to:. * Replace diseased, nonfunctioning bone marrow with healthy functioning bone marrow ( ...
In later-generation heterozygotes, we observed a decrease in tissue renewal capacity in the bone marrow, intestines, and testes ... Short telomeres, even in the presence of telomerase, limit tissue renewal capacity Cell. 2005 Dec 16;123(6):1121-31. doi: ...
Bone marrow failure (for example, due to granuloma, tumor, fibrosis). *Presence of cytotoxic substance collagen-vascular ...
After the exclusion of HIV and malignancies (biopsy of an inguinal lymph node, bone marrow biopsy, and PET), an idiopathic CD4 ... To exclude the presence of a lymphoma, the patient underwent exploratory laparotomy. A biopsy of liver and of a lymph node at ... The bone marrow aspirate excluded lymphoproliferative and parasitic disorders. Renal biopsy showed a tubulointerstitial ... All of these criteria were satisfied, except for the presence of IgG4 at renal biopsy which was not evaluated at time of renal ...
  • In this study we tested the effect of donor bone marrow transplantation (DBMT) under short-term alpha-betaTCRmAb and CsA 7-day protocol on development of donor chimerism, allograft survival, and presence of regulatory T-cells in face allograft model across MHC barrier. (aaps1921.org)
  • Therefore, the subtype of cells from the bone marrow responsible for engraftment is not yet known, nor is the ideal transplantation regimen known. (clinicaltrials.gov)
  • In this study we will evaluate safety and feasibility of autologous bone marrow mono nuclear (BM-MNC) and enriched CD133+ hematopoietic stem cell transplantation through the portal vein in patients with decompensate cirrhosis. (clinicaltrials.gov)
  • Bone marrow transplantation (BMT) is a special therapy for patients with certain cancers or other diseases. (childrensnational.org)
  • Determine the hematopoietic recovery in patients with hematologic malignancies or genetic disorders treated with fludarabine and melphalan followed by allogeneic or syngeneic bone marrow or peripheral blood stem cell transplantation. (knowcancer.com)
  • Patients undergo allogeneic or syngeneic bone marrow or peripheral blood stem cell transplantation on day 0. (knowcancer.com)
  • Experimental studies have shown that transplantation of bone marrow-derived cells may contribute to the regeneration of infarcted myocardium. (ahajournals.org)
  • Stem cells repair the marrow vascular niche following bone marrow transplantation. (freepatentsonline.com)
  • Here we show that treatment of human MM cells (IL-6-dependent MM cell line INA-6 and primary MM cells) with the IL-6 receptor antagonist Sant7 or with an anti-gp130 monoclonal antibody (mAb) induced apoptosis if the cells were cultured in the absence of bone marrow stromal cells (BMSCs). (mdc-berlin.de)
  • We used immunocytochemistry, Western blotting, nuclear binding assays, and transient transfection studies to examine the expression of functional TR isoforms in primary cultures of osteoblasts (hOb) derived from explants of trabecular bone, in human bone marrow stromal cells (hBMS), which are believed to be the source of osteoblast progenitor cells, and for comparison in the transformed human osteosarcoma cell lines MG63 and SaOs-2. (nih.gov)
  • Immunoregulatory effects on T lymphocytes by human mesenchymal stromal cells isolated from bone marrow, amniotic fluid, and placenta. (sigmaaldrich.com)
  • There is considerable interest in the biology and therapeutic potential of adult stem cells from bone marrow stroma, variously referred to as mesenchymal stem cells or marrow stromal cells (MSCs). (wiley.com)
  • One strategy for cell and gene therapy is to use adult stem cells from bone marrow stroma [ 1 - 4 ], referred to as mesenchymal stem cells or marrow stromal cells (MSCs). (wiley.com)
  • Bone marrow mesenchymal stromal cells (BM-MSCs) are referred as a promising immunotherapeutic cell product. (springer.com)
  • Fayyad-Kazan H, Faour WH, Badran B, Lagneaux L, Najar M. The immunomodulatory properties of human bone marrow-derived mesenchymal stromal cells are defined according to multiple immunobiological criteria. (springer.com)
  • Bone marrow mesenchymal stromal cells induce proliferative, cytokinic and molecular changes during the T cell response: the importance of the IL-10/CD210 axis. (springer.com)
  • In this study we have analyzed the interaction between in vitro cultured bone marrow stromal cells (BMSC) and NK cells. (jimmunol.org)
  • 10% and/or presence of a biopsy-proven plasmacytoma, 2. (mdanderson.org)
  • Bone marrow aspiration and biopsy are procedures used to collect and evaluate bone marrow cells and structure. (labtestsonline.org)
  • The biopsy sample is evaluated to determine the relationships of bone marrow cells to one another and the overall cellularity - the relative ratio of marrow cells to fat and other constituents present in the sample. (labtestsonline.org)
  • 20% bone marrow blasts per bone marrow biopsy/aspirate at screening. (centerwatch.com)
  • Thus, its presence in a patient who is anemic suggests bone marrow infiltration, even before the biopsy specimen is obtained. (medscape.com)
  • Diagnosis requires demonstration of peripheral normocytic anemia and a normocellular bone marrow biopsy with absence of erythroid maturation. (blogarama.com)
  • A biopsy, bone marrow tests, and several scans are performed which confirm that the cancer cells do indeed remain in his neck. (wikipedia.org)
  • Interestingly, women who have had bone marrow transplants have been found to have donor tissue in their endometrium, which raises the possibility of cellular therapies using bone marrow derived cells for gynecologic indications. (clinicaltrials.gov)
  • But after chemotherapy and more bone marrow transplants, she pulled through. (myfox8.com)
  • What are the different types of bone marrow transplants? (childrensnational.org)
  • There are different types of bone marrow transplants depending on who the donor is. (childrensnational.org)
  • In small initial studies, combined kidney and bone marrow transplants from the same donor have permitted some individuals to stop taking anti-rejection medicines without rejecting their transplant. (clinicaltrials.gov)
  • Transplant recipients enrolled in the study will receive both kidney and bone marrow transplants from the same living donor. (clinicaltrials.gov)
  • Bone marrow transplants may also be needed if the bone marrow has been destroyed by a disease. (ahealthyme.com)
  • The risks and benefits must be weighed in a thorough discussion with your healthcare provider and specialists in bone marrow transplants before the procedure. (ahealthyme.com)
  • Unrelated bone marrow transplants (UBMT or MUD for matched unrelated donor). (ahealthyme.com)
  • Engineers at the University of California San Diego have developed biomimetic bone tissues that could one day provide new bone marrow for patients needing transplants. (eurekalert.org)
  • Bone marrow transplants are used to treat patients with bone marrow disease. (eurekalert.org)
  • The effects of passive immunization on cytomegalovirus infection and interstitial pneumonia in marrow transplants were evaluated in a randomized, controlled trial. (annals.org)
  • These results suggest that passive immunization modifies cytomegalovirus infection in humans and prevents interstitial pneumonia in marrow transplants, especially when leukocyte transfusions are not used. (annals.org)
  • A bone marrow transplant involves taking cells that are normally found in the bone marrow (stem cells), filtering those cells, and giving them back either to the patient they were taken from or to another person. (childrensnational.org)
  • Anemia (low red blood cell count) and circulating lymphoblasts (immature cells normally found in the bone marrow, but may be found in the blood in cats with lymphosarcoma) may also be found. (cat-world.com.au)
  • Bone marrow transplant has been used successfully to treat diseases such as leukemias, lymphomas, aplastic anemia, immune deficiency disorders, and some solid tumor cancers since 1968. (ahealthyme.com)
  • Aplastic anemia is a diseased condition resulting from the bone marrow's inability to replenish blood cells. (petmd.com)
  • Your veterinarian will also evaluate your cat for the presence of any infectious diseases, but the most valuable test in the diagnosis of aplastic anemia is bone marrow sampling. (petmd.com)
  • Aplastic anemia is a life-threatening condition resulting when normal bone marrow is replaced by adipose (fat) tissue, thus preventing it from releasing the required number of WBCs, RBCs, and platelets and resulting in an overall decrease in the total number of these cells in the blood. (petmd.com)
  • Examples include aplastic anemia, in which the body can't make enough platelets and blood cells, as well as low blood counts and immune attack of the bone marrow caused by defective or abnormal bone marrow stem cells. (eurekalert.org)
  • Patients with otherwise normal functioning bone marrow may even recover without having known they had it. (blogarama.com)
  • Presence of significant extrahepatic biliary disease (e.g. (clinicaltrials.gov)
  • When a child's bone marrow has been damaged or destroyed due to a disease or intense treatments of radiation or chemotherapy for cancer, a bone marrow transplant may be needed. (childrensnational.org)
  • One of the causes for this disease involves replacement of normal bone marrow tissue by adipose (fat) tissue, thus minimizing the functional capacity of the bone marrow to produce cells. (petmd.com)
  • Unfortunately, approximately 70-80% of patients older than 18 months present with metastatic disease, usually in the lymph nodes, liver, bone, and bone marrow. (medscape.com)
  • In the future, our work could contribute to improved therapies for bone marrow disease," said Yu-Ru (Vernon) Shih, a research scientist in Varghese's lab and the study's first author. (eurekalert.org)
  • Objective To evaluate minimal disseminated disease (MDD) in the bone marrow (BM) and the cerebrospinal fluid (CSF) at diagnosis and during follow-up and reviewing its potential impact in the outcome of patients with TRb. (bmj.com)
  • Nieman-Pick disease (NPD) refers to a heterogenous group of disorders the common features of which include autosomal recessive inheritance, hepatosplenomegaly, and accumulation of variable amounts of sphingomyelin and other lipids in liver, spleen, and bone marrow. (alzheimer-europe.org)
  • Most patients diagnosed in adulthood have evidence of systemic disease defined by presence of pathologic mast cells in a non-cutaneous tissue (usually bone marrow). (worldallergy.org)
  • PCR - polymerase chain reaction - is a technique used to identify the presence of disease-causing viruses and/or bacteria. (prohealth.com)
  • WM cells display characteristics of both lymphocytes and plasma cells with gene expression profiling revealing a phenotype more similar to chronic lymphocytic leukemia than multiple myeloma (MM). At its core, WM is a clonal disease of B-lymphocytes and is characterized by the presence of (1) a monoclonal IgM immunoglobulin (M-protein), (2) malignant lymphoplasmacytic cell infiltration in the bone marrow. (atlasgeneticsoncology.org)
  • Clinically, WM presents similarly to MM except that organomegaly and lymphadenopathies are common in WM but not in MM, and lytic bone disease and renal disease are uncommon in WM but common in MM. (atlasgeneticsoncology.org)
  • Enlarged and immature red blood cells are found in bone marrow and they confirm the diagnosis. (medindia.net)
  • The diagnosis of myelofibrosis or neoplastic involvement of bone marrow is often suggested by evidence of myeloid metaplasia in the peripheral smear (ie, erythroid and granulocyte precursors). (medscape.com)
  • To confirm a diagnosis of bone marrow lymphosarcoma and document bone marrow involvement with other forms of lymphosarcoma. (cat-world.com.au)
  • 1.5x109/L. Presence of two or more phenotypical abnormalities can aid a diagnosis of CMML in the absence of identifying cytogenetic or dysplastic features. (wikipedia.org)
  • A doctor may make a diagnosis of hairy cell leukemia based on physical exams, medical questions, and tests that look at the person's blood and bone marrow cells. (medicalnewstoday.com)
  • The presence of osteoporosis in young males should alert the treating physician to the possibility of a diagnosis of mastocytosis. (worldallergy.org)
  • In adults, Burkitt's lymphoma frequently produces a bulky abdomen and may involve the liver, spleen, and bone marrow . (encyclopedia.com)
  • Replacement of bone marrow with nonhemopoietic cells leads to activation of fetal sites of blood production in organs such as the liver and the spleen, with release of abnormally shaped erythrocytes and normoblasts, immature granulocytes and normoblasts, immature granulocytes, and large platelets into the peripheral blood. (medscape.com)
  • Spleen, liver and bone marrow may also be involved. (cat-world.com.au)
  • When metastasis does occur, it is usually to the liver, spleen, lymph nodes and bone marrow. (wikipedia.org)
  • The bone marrow is a soft, spongy tissue found inside the bones. (childrensnational.org)
  • In later-generation heterozygotes, we observed a decrease in tissue renewal capacity in the bone marrow, intestines, and testes that resembled defects seen in dyskeratosis congenita patients. (nih.gov)
  • Bone marrow is the soft and sponge-like tissue found inside the body's larger bones that produces blood cells. (labtestsonline.org)
  • With the development of osteoimmunology and bone tissue engineering (BTE), it has been recognized that the immunomodulatory properties of bone biomaterials have considerable impact in determining their fate after implantation. (springer.com)
  • Infiltration of the bone marrow with fibrous tissue, neoplastic cells, or other cells that replace normal hematopoietic tissue can diminish the production of RBCs, granulocytes, and platelets. (medscape.com)
  • Yellow bone marrow stores fatty tissue. (cancer.ca)
  • and that host and donor cells can travel between the implanted marrow and the host's circulating blood -- via the blood vessel network formed in the implanted bone tissue. (eurekalert.org)
  • Mast cells originate from the bone marrow and are normally found throughout the connective tissue of the body as normal components of the immune system. (wikipedia.org)
  • A bone marrow aspiration collects a sample of the fluid that contains cells so that they can be examined under a microscope and/or evaluated with other tests. (labtestsonline.org)
  • Bone marrow aspiration commonly shows the presence of foam cells. (alzheimer-europe.org)
  • Flow cytometry assessed immunodepletion of T-lymphocytes, donor-specific chimerism for MHC class I (RT1 n ) antigens and presence of regulatory T-cells (Treg) CD4+/CD25+. (aaps1921.org)
  • Ryals, 26, signed up to be a bone marrow donor in college. (myfox8.com)
  • She had always thought donating blood and platelets was important, so when she found out you could donate bone marrow, she knew she wanted to register as a donor. (myfox8.com)
  • Shortly after Skye's first transplant from Ryals, the donor sent the family an anonymous letter through Be the Match , the nonprofit organization through which she donated her bone marrow. (myfox8.com)
  • Stem cells are taken either by bone marrow harvest or apheresis from a genetically-matched donor, often a brother or sister. (childrensnational.org)
  • Researchers have found that transplanting both bone marrow and a kidney from the same donor can create what is called 'mixed chimerism. (clinicaltrials.gov)
  • In a small prior study, performing a kidney transplant together with a bone marrow transplant from the same donor allowed 4 of 5 patients to stop taking immunosuppressive drugs altogether, without rejecting their transplant. (clinicaltrials.gov)
  • The genetically matched marrow or stem cells are from an unrelated donor. (ahealthyme.com)
  • Donor-derived vasculogenesis occurred whether whole bone marrow cells, isolated stem cells, or single stem cells were transplanted. (freepatentsonline.com)
  • This pre-treatment is meant to improve success of the transplant by clearing up space in the marrow, allowing donor cells to survive and grow without competition from the patient's own cells. (eurekalert.org)
  • To address these issues, a team led by bioengineering professor Shyni Varghese at the UC San Diego Jacobs School of Engineering has developed a bone-like implant that gives donor cells their own space to live and grow without competition, eliminating the need to wipe out the host's pre-existing cells. (eurekalert.org)
  • We've made an accessory bone that can separately accommodate donor cells. (eurekalert.org)
  • Researchers developed bone tissues with functional bone marrow that can be filled with donor cells and implanted under the skin of mice. (eurekalert.org)
  • After four weeks, researchers found that the implanted marrow contained a mix of host and donor blood cells. (eurekalert.org)
  • Matrigel plugs were established in irradiated mice that had been reconstituted using bone marrow cells from an EGFP + donor. (biologists.org)
  • Megaloblastic anemia is a type of anemia characterized by the formation of unusually large, abnormal and immature red blood cells called as megaloblasts by the bone marrow, which are released into the blood. (medindia.net)
  • Red bone marrow is where blast cells (immature blood cells) develop into red blood cells, white blood cells and platelets. (cancer.ca)
  • In CMML, there are increased numbers of monocytes and immature blood cells (blasts) in the peripheral blood and bone marrow, as well as abnormal looking cells (dysplasia) in at least one type of blood cell. (wikipedia.org)
  • Bone marrow core biopsies may show a predominance of myelocytic and monocytic cells, abnormal localisation of immature precursors and dysplastic megakaryocytes. (wikipedia.org)
  • 2.5 x 109/L, >0% immature myeloid cells, >10% bone marrow blasts causes a reduced overall survival. (wikipedia.org)
  • bone marrow blasts ≥5%, LDH >200U/L, haemoglobin ≤9g/dL and a platelet count ≤100,000/uL. (wikipedia.org)
  • Azacitidine is a drug approved by the US Food & Drug Administration (FDA) for the treatment of CMML and by the European Medicines Agency for high risk non-proliferative CMML with 10-19% marrow blasts. (wikipedia.org)
  • When the doses of chemotherapy or radiation needed to cure a cancer are so high that a person's bone marrow stem cells will be permanently damaged or destroyed by the treatment, a bone marrow transplant may be needed. (ahealthyme.com)
  • Collection of a small sample of the person's bone marrow, blood, or bone by inserting a hollow needle into the bone in the hip or breast area. (medicalnewstoday.com)
  • There are 2 main types of bone marrow. (cancer.ca)
  • The trabecular bone structure, commonly reported using Fiesta-c imaging cannot be evaluated reliably within the region with Bone Marrow Edema-like Lesions (BMEL) due to presence of water which is also dark (as the bone) in these regions. (ismrm.org)
  • normal, [B] Lytic bone lesions or osteoporosis. (mdanderson.org)
  • Although bone marrow lesions (BML) have been implicated in the pathogenesis of osteoarthritis, their natural history in a healthy population is unknown. (bmj.com)
  • This system allows the in vitro study of the process of stem cell proliferation and differentiation and also provides a means to examine the relationship of adherent and supernatant bone marrow populations. (ashpublications.org)
  • Every type of blood cell in the bone marrow begins as a stem cell. (childrensnational.org)
  • Although bone marrow represents the main source of MSCs, there remains a need to identify a stem cell source that is safe and easily accessible and yields large numbers of cells without provoking debates over ethics. (sigmaaldrich.com)
  • This condition typically occurs during a stem cell or bone marrow transplant from another individual. (medindia.net)
  • Less than half of these patients are cured, even with the use of high-dose therapy followed by autologous bone marrow or stem cell rescue. (medscape.com)
  • Nearly every cell in an animal's body, from neural to blood to bone, owes its existence to a stem cell. (google.com)
  • A generalized marrow dysfunction with an abnormal bone marrow stroma (in terms of its ability to support and maintain hematopoiesis) is thought to be present in addition to a stem cell defect. (medscape.com)
  • A maintenance period of 2 years has been chosen based on Center for International Blood and Marrow Transplant Research data which indicate the vast majority of AML relapses occur by this time after allogeneic hematopoietic stem cell transplant. (rush.edu)
  • However, most data concerning the role of IL-6 and IL-6-triggered signaling pathways were obtained from experiments performed with MM cell lines and without considering the bone marrow microenvironment. (mdc-berlin.de)
  • These observations indicate that the IL-6/gp130/STAT3 pathway is not essential for survival of human myeloma cells if they are grown in the presence of cells from the bone marrow microenvironment. (mdc-berlin.de)
  • The researchers conducted a number of experiments to test the formation and vitality of cells in and near the bone marrow microenvironment. (eurekalert.org)
  • Techniques for the development of ovine bone marrow-derived haemopoietic progenitor cells and in situ identification of colony morphology are described. (semanticscholar.org)
  • Evaluations for the possible causes of PRCA should include a previous history of drug use and toxins or infections, liver and kidney functions, immunological examination including auto-antibodies, a bone marrow examination including morphology, chromosome and rearrangement of T cell receptor (TCR) analysis, peripheral-blood flow cytometry, virological examination including parvovirus B19 DNA, and computed tomography and/or magnetic resonance imaging examinations to rule out the presence of thymoma and neoplasms. (blogarama.com)
  • In contrast, addition of SCM to hamster bone marrow cultures containing both adherent cells and hematopoietic stem cells produced no change in the number of mixed colonies generated in the culture. (ashpublications.org)
  • To further validate the IL-6 affect on hematopoietic cell expansion, bone marrow cells derived from wild-sort and IL-6 deficient mice were isolated and cultured with a single therapy of Flt-3L, PTH or combined treatment for a time period of eight days. (c14-demethylase.com)
  • Paper title: "In vivo engineering of bone tissues with hematopoietic functions and mixed chimerism" by Yu-Ru (Vernon) Shih), Heemin Kang, Vikram Rao, Yu-Jui Chiu, Seung Keun Kwon and Shyni Varghese of UC San Diego. (eurekalert.org)
  • We show that the place where HSCs form in the bone marrow loses osteopontin upon aging, but if you give back the missing protein to the blood-forming cells they suddenly rejuvenate and act younger," says Hartmut Geiger, PhD, study lead investigator at the Institute for Molecular Medicine and Aging Research Center at the University of Ulm , and the Division of Experimental Hematology and Cancer Biology at Cincinnati Children's. (eurekalert.org)
  • The granulocytes form in the bone marrow and account for about 70% of all white blood cells. (encyclopedia.com)
  • Tumors were classified into five pre-defined molecular subtypes, and 23 March 2007 presence of DTC identified (at median 85 months follow-up) a subgroup of luminal A Accepted 26 March 2007 patients with particular poor outcome ( p ¼ 0.008). (spotidoc.com)
  • Presence of disseminated tumor cells (DTCs) in bone marrow (BM) as an independent prognostic factor for breast cancer patients receiving adjuvant systemic treatment as well as for untreated patients, is now well documented (Braun et al. (spotidoc.com)
  • The presence of EBV in patients with endemic Burkitt's has been interpreted as a side effect of the high rates of malaria in central Africa. (encyclopedia.com)
  • However, patients experience diseases differently, and bone marrow transplant may not be right for everyone who suffers from these diseases. (ahealthyme.com)
  • 4 Therefore, we performed a randomized controlled trial to assess the functional effect of direct intramyocardial injection of autologous bone marrow cells on left ventricular ejection fraction (LVEF) in patients with a chronic myocardial infarction undergoing coronary artery bypass graft (CABG) surgery. (ahajournals.org)
  • Patients were randomly allocated in a 1:1 ratio to either the control, conventional CABG, or bone marrow cell (BMC) group, by means of sequentially numbered sealed envelopes. (ahajournals.org)
  • Varghese cautions that these implants would be limited to patients with non-malignant bone marrow diseases, where there aren't any cancerous cells that need to be eliminated. (eurekalert.org)
  • Osteoporosis due to mastocytosis is becoming increasingly acknowledged, can occur in up to 30% of patients with systemic mastocytosis and has been associated with the increase in urinary histamine excretion and the increased presence of serum IL-6. (worldallergy.org)
  • All patients with systemic mastocytosis should undergo a bone mineral density scan. (worldallergy.org)
  • Blood and bone marrow from 35 RA patients were analysed for CMV (cytomegalovirus, a member of the herpes virus family), EBV (Epstein-Barr), HSV-1, HSV-2 (herpes simplex viruses), parvovirus B19 and polyomavirus using real-time PCR before and 3 months after rituximab (RTX) treatment and related to the levels of autoantibodies and B-cell depletion. (prohealth.com)
  • EBV and parvovirus genomes are frequently found in bone marrow of RA patients. (prohealth.com)
  • Given the aggressive nature of AML and the exceptionally poor prognosis at relapse, allogeneic bone marrow transplant is now widely recommended for these patients. (rush.edu)
  • Scientists followed up the earlier experiments by transplanting bone marrow cells from older mice (19-21 months) into young mice (8 to 10 weeks). (eurekalert.org)
  • Cancer is found in the lungs, liver, bone marrow, or cerebrospinal fluid of the brain and spinal cord. (epnet.com)
  • The primary function of the bone marrow is to produce red blood cells (RBCs), platelets, and white blood cells (WBCs). (labtestsonline.org)
  • Bone marrow contains stem cells which develop into the red blood cells that carry oxygen through the body, the white blood cells that fight infections, and the platelets that help with blood clotting. (blogarama.com)
  • Bone marrow plays a pivotal role in the constant replenishment of important cells like red blood cells (RBCs), granulocytes (or white blood cells [WBCs]), and platelets. (petmd.com)
  • Replace the bone marrow and restore its normal function after high doses of chemotherapy or radiation are given to treat cancer. (childrensnational.org)
  • This can restore damaged bone marrow following high-dose chemotherapy or radiation therapy . (medicalnewstoday.com)
  • It is characterized by an absence of red cell precursors (reticulocytes) in the marrow and a low red blood cell count. (blogarama.com)
  • This molecular image shows immunofluorescence staining in the soft spongy section of trabecular bone in the femur of a young mouse. (eurekalert.org)
  • OBJECTIVE: In previous work, we showed that CD34+ bone marrow cells can be successfully expanded along the myeloid pathway in stroma- and serum-free conditions in the presence of SCF+IL-3+IL-6+Flt3-l+G-CSF+MGDF. (irsn.fr)
  • In NK proliferation assays, the cells were maintained over stroma cells in the presence of IL-2 for 4-5 weeks. (irsn.fr)
  • The prognostic impact of the presence of differentiating neuroblasts in bone marrow (BM) remains unclear in BM metastatic neuroblastoma (NB). (bvsalud.org)
  • Prior to the transplant procedure, the transplant recipient will undergo a 'conditioning regimen' that prepares their immune system for the recipient's immune (bone marrow) cells. (clinicaltrials.gov)
  • In vivo study confirmed that BMSCs combined with Lap initiated a less severe immune response and had an improved effect on bone regeneration compared with Lap alone, which corresponded with the in vitro evaluation. (springer.com)
  • The immune system's reaction to the presence of foreign substances in the body. (cancer.ca)
  • This type of cancer starts in the tissues that form blood, such as the bone marrow, or in the cells of the immune system. (medicalnewstoday.com)
  • This includes the presence of smaller numbers of HSCs with greater potential for forming different types of blood cells, which included larger populations of B and T cells and smaller production of myeloid cells. (eurekalert.org)
  • What does the presence of myeloid metaplasia suggest in the workup of anemia? (medscape.com)
  • Pure red cell aplasia in adults can be easily diagnosed when isolated anaemia, in the presence of normal white cell and platelet counts, is associated with a marrow of normal cellularity in which there is an almost complete absence of erythroblasts but normal myeloid cells and megakaryocytes (Dessypris & Lipton, 2004). (blogarama.com)
  • The goal of BMT is to transfuse healthy bone marrow cells into a person after his or her own unhealthy bone marrow has been treated to kill the abnormal cells. (ahealthyme.com)
  • RESULTS: Fourteen (41%) of the 34 knees had bone marrow edema, eight (24%) showed signal in the patellar tendon, and 14 (41%) had abnormal cartilage signal or a focal abnormality. (duke.edu)
  • A method is described for generating a clinically significant volume of neural progenitor cells from whole bone marrow. (google.com)
  • Embodiments of the present invention are directed to a method for generating a clinically substantial volume of neural progenitor cells from mammalian whole bone marrow. (google.com)
  • Fewer than 1% of bone marrow transplant recipients get it as a result of their transplant. (myfox8.com)
  • a type of lymphocyte, developed in bone marrow, that circulates in the blood and lymph and, upon encountering a particular foreign antigen, differentiates into a clone of plasma cells that secrete a specific antibody and a clone of memory cells that make the antibody on subsequent encounters. (dictionary.com)
  • Unsure of what was happening, his parents Darlene and David took him to Children's National Health System and soon found out that Christopher had acute lymphoblastic leukemia (ALL), a type of blood and bone marrow cancer that affects white blood cells. (childrensnational.org)
  • Background- Recent trials have shown that intracoronary infusion of bone marrow cells (BMCs) improves functional recovery after acute myocardial infarction. (ahajournals.org)
  • 1 Based on those data, 2 clinical trials have shown that intracoronary infusion of autologous bone marrow cells improves left ventricular functional recovery after acute myocardial infarction and successful percutaneous coronary intervention. (ahajournals.org)
  • A bone marrow aspirate was obtained from a 59-year-old Caucasian male with erythroleukemia that evolved into acute myelogenous leukemia. (atcc.org)
  • The potential for stem cells in bone marrow (BM) to differentiate into hepatocytes cells was recently confirmed. (clinicaltrials.gov)
  • Stem cells, when transplanted, find their way to the recipient's marrow and begin to differentiate (mature) and produce all types of blood cells that are needed by the body. (childrensnational.org)
  • Stem cells grown in this mineralized matrix differentiate into bone-building cells. (eurekalert.org)
  • KG-1 myeloblasts can differentiate into macrophages in the presence of phorbol esters. (atcc.org)
  • To figure out if IL-6 is a element implicated in the ex vivo bone marrow amplification noticed in the existence of PTH and Flt-3L, bone marrow cells had been cultured for 8 times with a single remedy of PTH, Flt-3L or PTH plus Flt-3L in the existence and absence of IL-6 at the time of plating. (c14-demethylase.com)
  • The mammalian in vivo chromosome aberration test is used for the detection of structural chromosome aberrations induced by test compounds in bone marrow cells of animals, usually rodents (rats, mice and Chinese hamsters). (oecd.org)
  • 1977. Comparative in vivo mutagenicity testing by SCE and micronucleus induction in mouse bone marrow. (cdc.gov)
  • Examination of a peripheral blood smear show the presence of enlarged, irregular and abnormally shaped red blood cells. (medindia.net)
  • NEW YORK (Reuters Health) - In women undergoing breast-conserving therapy for early breast cancer, the presence of occult metastasis not seen with routine pathological examination in sentinel lymph nodes (SLNs) is not associated with poorer survival. (thedoctorschannel.com)
  • Interestingly, the amplification of both populations, with Flt-3L on your own or mixed with PTH was decrease in the bone marrow cultures derived from the IL-6 deficient mice. (c14-demethylase.com)
  • Complete bone marrow was isolated from wild-kind mice and seeded at 1.86105 cells/cm2 in the existence or absence of Flt-3L (a hundred ng/ml), PTH (10 nM), a mixture of both, or motor vehicle only, (A) Circulation cytometric analyses of Annexin V+ Propidium Iodide- (early apoptosis) cells executed on non-adherent cells. (c14-demethylase.com)
  • When implanted beneath the skin of mice, the structures matured into bone tissues that have a working blood vessel network and a bone marrow inside that supplies new blood cells. (eurekalert.org)
  • In another set of experiments, researchers took stem cells from the implanted marrow and transplanted them into a second group of mice that had their marrow stem cells destroyed by radiation and drugs. (eurekalert.org)
  • Breast cancer Micrometastases in bone marrow ª 2007 Federation of European Biochemical Societies. (spotidoc.com)
  • Stricken with childhood cancer, she needed a bone marrow transplant to survive. (myfox8.com)
  • The goal of a bone marrow transplant is to cure many diseases and certain types of cancer. (childrensnational.org)
  • INNSBRUCK, Austria, Aug. 25-The presence of bone marrow micrometastases in women newly diagnosed with breast cancer is a highly significant predictor of poor outcome, according to a pooled analysis of data from nine breast cancer studies. (medpagetoday.com)
  • The bone marrow in the hips, breast bone, spine, ribs, and skull contains cells that produce the body's blood cells. (childrensnational.org)
  • The bone marrow is responsible for the development and storage of most of the body's blood cells. (childrensnational.org)
  • Bone marrow and/or blood cells are collected, prepared and stained. (oecd.org)
  • These stem cells reproduce into mature, functioning blood cells quicker and more effectively than do stem cells taken from the bone marrow of another child or adult. (ahealthyme.com)
  • For instance, in some types of MDS, lymphocytes may attack the bone marrow, causing it to stop making enough healthy blood cells. (lls.org)
  • It can be described as a slow increase in the number of white blood cells in the blood and the bone marrow. (marketsandmarkets.com)
  • In people with PRCA, the bone marrow makes a reduced number of red blood cells (called anemia). (blogarama.com)
  • Red cell aplasia is a rare condition where the bone marrow doesn't make enough red blood cells, which causes anemia. (cancer.ca)
  • In adults, blood cells are formed in the bone marrow, by a process that is known as haematopoiesis. (wikipedia.org)
  • In some mammals, it is estimated that as many as three million red blood cells per second are released into the blood circulation, demonstrating the extensive amount of work done by the bone marrow in keeping the numbers of these cells within normal ranges in the body. (petmd.com)
  • Explain to women that the presence of bone marrow micrometastases may help determine effective treatment options. (medpagetoday.com)
  • Ovine haemopoiesis: the development of bone marrow-derived colony-forming cells in vitro in the presence of factors derived from lymphoid cells and helper T-cells. (semanticscholar.org)
  • article{Haig1990OvineHT, title={Ovine haemopoiesis: the development of bone marrow-derived colony-forming cells in vitro in the presence of factors derived from lymphoid cells and helper T-cells. (semanticscholar.org)
  • A bone marrow transplant is a procedure to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. (rush.edu)
  • Shwachman-Diamond syndrome (SDS) is a rare autosomal recessive disorder characterized by exocrine pancreatic insufficiency, bone marrow dysfunction, and skeletal abnormalities. (medscape.com)
  • Chromosome preparations are then made from the bone marrow cells and stained, and metaphase cells are analysed for chromosome aberrations. (oecd.org)
  • Metaphase cells are analysed microscopically for the presence of chromosome aberrations. (oecd.org)
  • Any of the lymphocytes that develop into plasma cells in the presence of a specific antigen. (dictionary.com)
  • Stem cells are taken from the child either by bone marrow harvest or apheresis (a process of collecting peripheral blood stem cells) and then given back to the child after intensive treatment. (childrensnational.org)
  • Shwachman-Diamond syndrome is the second most common cause of inherited pancreatic insufficiency after cystic fibrosis and the third most common inherited bone marrow failure syndrome after Fanconi anemia and Blackfan-Diamond anemia. (medscape.com)
  • Whereas a variety of reports highlight the immunomodulation of bone marrow mesenchymal stem cells (BMSCs) in cell therapy or their osteogenesis in BTE, few have focused on the effect of BMSCs in promoting osteogenesis in BTE through regulating the phenotype of macrophages. (springer.com)
  • This species is the causative agent of cutaneous leishmaniasis, and its role during interactions with bone marrow-derived macrophages (BMDMs) and peritoneal B-1 cells was evaluated. (frontiersin.org)
  • Sections of 5 day ( A-D ) and 9 day ( E-H ) Matrigel plugs were stained for DAPI (blue), NG2 (magenta), CD31 (green) and F4/80 (red) to investigate the presence of macrophages in developing vessels. (biologists.org)
  • In this study, MSCs isolated from amniotic fluid and placenta were compared with bone marrow MSCs. (sigmaaldrich.com)
  • To gain a better understanding of the regulation of cellular differentiation by mechanical cues, we investigated the influence of matrix stiffness ( E = 1.46 kPa and E = 26.12 kPa) on differentiated osteogenic cell lineage of bone marrow stem cells (BM-MSCs) and bone-derived cells (BDCs) using flexible collagen-coated polyacrylamide substrates. (wiley.com)
  • The sample can also reveal other characteristics of cells, including the size, shape, and presence of tumor markers on the cell surface. (medicalnewstoday.com)