The period before MENOPAUSE. In premenopausal women, the climacteric transition from full sexual maturity to cessation of ovarian cycle takes place between the age of late thirty and early fifty.
The transitional period before and after MENOPAUSE. Perimenopausal symptoms are associated with irregular MENSTRUAL CYCLE and widely fluctuated hormone levels. They may appear 6 years before menopause and subside 2 to 5 years after menopause.
The last menstrual period. Permanent cessation of menses (MENSTRUATION) is usually defined after 6 to 12 months of AMENORRHEA in a woman over 45 years of age. In the United States, menopause generally occurs in women between 48 and 55 years of age.
The periodic shedding of the ENDOMETRIUM and associated menstrual bleeding in the MENSTRUAL CYCLE of humans and primates. Menstruation is due to the decline in circulating PROGESTERONE, and occurs at the late LUTEAL PHASE when LUTEOLYSIS of the CORPUS LUTEUM takes place.
Physiologic period, characterized by endocrine, somatic, and psychic changes with the termination of ovarian function in the female. It may also accompany the normal diminution of sexual activity in the male.
Six-carbon alicyclic hydrocarbons which contain one or more double bonds in the ring. The cyclohexadienes are not aromatic, in contrast to BENZOQUINONES which are sometimes called 2,5-cyclohexadiene-1,4-diones.
The interactions between physician and patient.
Truthful revelation of information, specifically when the information disclosed is likely to be psychologically painful ("bad news") to the recipient (e.g., revelation to a patient or a patient's family of the patient's DIAGNOSIS or PROGNOSIS) or embarrassing to the teller (e.g., revelation of medical errors).
Facilities having programs intended to promote and maintain a state of physical well-being for optimal performance and health.

Oxytocin and vasopressin receptors in human and uterine myomas during menstrual cycle and early pregnancy. (1/1495)

The purpose of this study was to determine the specificity and concentration of oxytocin (OT) and arginine vasopressin (AVP) binding sites in non-pregnant (NP) human and rhesus monkey endometrium, myometrium and fibromyomas, and to determine the cellular localization of OT receptor (OTR). Besides [3H]AVP, [125I]LVA, a specific VP1 receptor subtype antagonist, was used to determine vasopressin receptor (VPR) concentrations. Samples were obtained from 42 pre-menopausal and three pregnant women (5, 13 and 35 weeks gestation), and several NP and pregnant monkeys. Specificity of binding was assessed in competition experiments with unlabelled agonists and antagonists of known pharmacological potency. Cellular localization of OTR was determined by immunohistochemistry. In NP human uterine tissues, [3H]AVP was bound with higher affinity and greater binding capacity than [3H]OT, whereas in pregnant women and in NP and pregnant rhesus monkeys, uterine OT binding capacity was greater. OT and AVP binding sites discriminated very poorly between OT and AVP; [125I]LVA binding sites were more selective than [3H]AVP. Their ligand specificity and binding kinetics indicated the presence of two distinct populations of binding sites for OT and AVP in primate uterus. Endometrium of NP women and monkeys had low OTR and VPR concentrations. Myometrial and endometrial OTR and VPR were down-regulated in midcycle and in early human pregnancy, they were up-regulated in the secretory phase and second half of pregnancy. Immunoreactive OTR in NP uterus was localized in patches of myometrial muscle cells and small numbers of endometrial epithelial cells.  (+info)

Glutathione-S-transferase (GSTM1) genetic polymorphisms do not affect human breast cancer risk, regardless of dietary antioxidants. (2/1495)

Glutathione-S-transferases catalyze the detoxication of carcinogen metabolites and reactive oxygen species (ROS) produced through a number of mechanisms. Glutathione-S-transferase (GST) M1 is polymorphic, and the null allele results in a lack of enzyme activity. Because there are indications that ROS may be involved in breast carcinogenesis, we sought to determine whether the GSTM1 null allele was associated with increased breast cancer, particularly among women with lower consumption of dietary sources of alpha-tocopherol, carotenoids and ascorbic acid. In a study of diet and cancer in western New York, women with primary, incident, histologically confirmed breast cancer (n = 740) and community controls (n = 810) were interviewed and an extensive food-frequency questionnaire administered. A subset of these women provided a blood specimen. DNA was extracted and genotyping performed for GSTM1. Data were available for 279 cases and 340 controls. The null allele did not increase breast cancer risk, regardless of menopausal status. There were also no differences in associations between the polymorphism and risk among lower and higher consumers of dietary sources of antioxidants or smokers and nonsmokers. These results indicate that GSTM1 genetic polymorphisms are not associated with breast cancer risk, even in an environment low in antioxidant defenses.  (+info)

Tumour necrosis factor-alpha (TNF-alpha) in human endometrium and uterine secretion: an evaluation by immunohistochemistry, ELISA and semiquantitative RT-PCR. (3/1495)

Tumour necrosis factor-alpha (TNF-alpha is a pleiotropic cytokine synthesized throughout the female reproductive tract. Even though evidence has accumulated that supports its role in autocrine and paracrine processes, its expression and function in the human endometrium are still not completely understood. To gain a better understanding of the synthesis and release of TNF-alpha in the endometrium and how this relates to concentrations in uterine secretion, its expression throughout the menstrual cycle was investigated by three different techniques. Samples of endometrial tissue and uterine secretions were collected from patients undergoing abdominal and vaginal hysterectomy for benign reasons. The mRNA expression of TNF-alpha was investigated in homogenized endometrial tissue by semiquantitative reverse transcription-polymerase chain reaction (RT-PCR) (n = 18). An assessment of the cellular TNF-alpha protein localization in the endometrial glands was performed immunohistochemically (n = 39). The concentrations of the secreted TNF-alpha protein in endometrial secretion were determined by enzyme-linked immunosorbent analysis (n = 30). All three methods gave similar results on the temporal expression of TNF-alpha mRNA and TNF-alpha protein during the cycle. Concentrations of endometrial TNF-alpha mRNA in tissue samples and TNF-alpha protein in uterine secretion were quite low at the beginning of the cycle, rose sharply in the mid- to late proliferative phase and decreased towards the end of the cycle. The concentrations of TNF-alpha protein in the endometrial glands, as shown by immunohistochemical investigation, stayed high throughout the secretory phase at values slightly below those of the late proliferative phase.  (+info)

Expression of prostate-specific antigen (PSA) correlates with poor response to tamoxifen therapy in recurrent breast cancer. (4/1495)

Prostate-specific antigen (PSA) is a serine protease which may play a role in a variety of cancer types, including breast cancer. In the present study, we evaluated whether the level of PSA in breast tumour cytosol could be associated with prognosis in primary breast cancer, or with response to tamoxifen therapy in recurrent disease. PSA levels were determined by enzyme-linked immunosorbent assay (ELISA) in breast tumour cytosols, and were correlated with prognosis in 1516 patients with primary breast cancer and with response to first-line tamoxifen therapy in 434 patients with recurrent disease. Relating the levels of PSA with classical prognostic factors, low levels were more often found in larger tumours, tumours of older and post-menopausal patients, and in steroid hormone receptor-negative tumours. There was no significant association between the levels of PSA with grade of differentiation or the number of involved lymph nodes. In patients with primary breast cancer, PSA was not significantly related to the rate of relapse, and a positive association of PSA with an improved survival could be attributed to its relationship to age. In patients with recurrent breast cancer, a high level of PSA was significantly related to a poor response to tamoxifen therapy, and a short progression-free and overall survival after start of treatment for recurrent disease. In Cox multivariate analyses for response to therapy and for (progression-free) survival, corrected for age/menopausal status, disease-free interval, site of relapse and steroid hormone receptor status, PSA was an independent variable of poor prognosis. It is concluded that the level of PSA in cytosols of primary breast tumours might be a marker to select breast cancer patients who may benefit from systemic tamoxifen therapy.  (+info)

Menopausal status and distensibility of the common carotid artery. (5/1495)

Although several studies have shown that exogenous estrogens have beneficial effects on arterial characteristics, the effect of endogenous estrogen on the vascular system is still unknown. In this study, distensibility, an indicator of arterial elasticity, of the common carotid artery was compared in pre- and postmenopausal women. The study comprised 93 premenopausal and 93 postmenopausal women of similar age (range, 43 to 55 years). Women were selected from respondents to a mailed questionnaire about the menopause, which was sent to all women aged 40 to 60 years in the Dutch town of Zoetermeer (n=12 675). Postmenopausal women who were at least 3 years past natural menopause or whose menses had stopped naturally before age 48, were age-matched with premenopausal women with regular menses and without menopausal complaints. The selection aimed at maximizing the contrast in estrogen status between pre- and postmenopausal women of the same age. Distensibility of the carotid artery was measured noninvasively with B-mode ultrasound and a vessel wall movement detector system. Arterial distensibility is expressed as the change in arterial diameter (distension, DeltaD) with the cardiac cycle, adjusted for lumen diameter, pulse pressure, and mean arterial blood pressure. Compared with premenopausal women, postmenopausal women had significantly lower arterial distension (DeltaD 370.5 microm [SE 9.5] versus 397.3 microm [SE 9.6]). These results suggest that the distensibility of the common carotid artery is negatively affected by natural menopause in presumed healthy women.  (+info)

Meta-analysis: dietary fat intake, serum estrogen levels, and the risk of breast cancer. (6/1495)

BACKGROUND: There is compelling evidence that estrogens influence breast cancer risk. Since the mid-1980s, dietary fat intervention studies have been conducted to investigate the effect of fat intake on endogenous estrogen levels. To further our understanding of the possible relationship between dietary fat and breast cancer, we conducted a meta-analysis of dietary fat intervention studies that investigated serum estradiol levels, and we reviewed the nature of the evidence provided by prospective analytic studies of fat consumption and breast cancer risk. METHODS: A computerized search of the English language literature on estrogen/estradiol and dietary fat intervention studies published from January 1966 through June 1998 was conducted using the MEDLINE database. Pooled estimates were derived from the change in estradiol levels associated with fat reduction from 13 studies. Analyses were conducted separately for premenopausal and postmenopausal women and in both groups combined. RESULTS AND CONCLUSIONS: Statistically significant reductions in serum estradiol levels of -7.4% (95% confidence interval [CI] = -11.7% to -2.9%) among premenopausal women and -23.0% (95% CI = -27.7% to -18.1%) among postmenopausal women were observed, with an overall -13.4% (95% CI = -16.6% to -10.1%) reduction observed. The greatest reductions occurred in two studies in which dietary fat was reduced to 10%-12% of calories compared with 18%-25% of calories in the other studies. A statistically significant reduction in estradiol levels of -6.6% (95% CI = -10.3% to -2.7%) remained after exclusion of these two studies. Review of prospective analytic epidemiologic studies that allowed for dietary measurement error suggests that the possibility that reducing fat consumption below 20% of calories will reduce breast cancer risk cannot be excluded. IMPLICATIONS: Dietary fat reduction can result in a lowering of serum estradiol levels and such dietary modification may still offer an approach to breast cancer prevention.  (+info)

Dietary carotenoids and vitamins A, C, and E and risk of breast cancer. (7/1495)

BACKGROUND: Data on intake of specific carotenoids and breast cancer risk are limited. Furthermore, studies of vitamins A, C, and E in relation to breast cancer risk are inconclusive. We have conducted a large, prospective study to evaluate long-term intakes of these nutrients and breast cancer risk. METHODS: We examined, by use of multivariate analysis, associations between intakes of specific carotenoids, vitamins A, C, and E , consumption of fruits and vegetables, and breast cancer risk in a cohort of 83234 women (aged 33-60 years in 1980) who were participating in the Nurses' Health Study. Through 1994, we identified 2697 incident cases of invasive breast cancer (784 premenopausal and 1913 postmenopausal). RESULTS: Intakes of beta-carotene from food and supplements, lutein/zeaxanthin, and vitamin A from foods were weakly inversely associated with breast cancer risk in premenopausal women. Strong inverse associations were found for increasing quintiles of alpha-carotene, beta-carotene, lutein/zeaxanthin, total vitamin C from foods, and total vitamin A among premenopausal women with a positive family history of breast cancer. An inverse association was also found for increasing quintiles of beta-carotene among premenopausal women who consumed 15 g or more of alcohol per day. Premenopausal women who consumed five or more servings per day of fruits and vegetables had modestly lower risk of breast cancer than those who had less than two servings per day (relative risk [RR] = 0.77; 95% confidence interval [CI] = 0.58-1.02); this association was stronger among premenopausal women who had a positive family history of breast cancer (RR = 0.29; 95% CI = 0.13-0.62) or those who consumed 15 g or more of alcohol per day (RR = 0.53; 95% CI = 0.27-1.04). CONCLUSIONS: Consumption of fruits and vegetables high in specific carotenoids and vitamins may reduce premenopausal breast cancer risk.  (+info)

The associations of bone mineral density and bone turnover markers with osteoarthritis of the hand and knee in pre- and perimenopausal women. (8/1495)

OBJECTIVE: To determine whether Caucasian women ages 28-48 years with newly defined osteoarthritis (OA) would have greater bone mineral density (BMD) and less bone turnover over time than would women without OA. METHODS: Data were derived from the longitudinal Michigan Bone Health Study. Period prevalence and 3-year incidence of OA were based on radiographs of the dominant hand and both knees, scored with the Kellgren/Lawrence (K/L) scale. OA scores were related to BMD, which was measured by dual-energy x-ray absorptiometry, and to serum osteocalcin levels, which were measured by radioimmunoassay. RESULTS: The period prevalence of OA (K/L grade > or =2 in the knees or the dominant hand) was 15.3% (92 of 601), with 8.7% for the knees and 6.7% for the hand. The 3-year incidence of knee OA was 1.9% (9 of 482) and of hand OA was 3.3% (16 of 482). Women with incident knee OA had greater average BMD (z-scores 0.3-0.8 higher for the 3 BMD sites) than women without knee OA (P < 0.04 at the femoral neck). Women with incident knee OA had less change in their average BMD z-scores over the 3-year study period. Average BMD z-scores for women with prevalent knee OA were greater (0.4-0.7 higher) than for women without knee OA (P < 0.002 at all sites). There was no difference in average BMD z-scores or their change in women with and without hand OA. Average serum osteocalcin levels were lower in incident cases of hand OA (>60%; P = 0.02) or knee OA (20%; P not significant). The average change in absolute serum osteocalcin levels was not as great in women with incident hand OA or knee OA as in women without OA (P < 0.02 and P < 0.05, respectively). CONCLUSION: Women with radiographically defined knee OA have greater BMD than do women without knee OA and are less likely to lose that higher level of BMD. There was less bone turnover among women with hand OA and/or knee OA. These findings suggest that bone-forming cells might show a differential response in OA of the hand and knee, and may suggest a different pathogenesis of hand OA and knee OA.  (+info)

The current study is a multicentre, randomized, open (unblended), prospective clinical trial which is sponsored by the researchers. The trial is designed to compare the effectiveness between docetaxel plus epirubicin, and docetaxel plus epirubicin plus cyclophosphamide as neoadjuvant chemotherapy for operable premenopausal breast cancer patients, and also to compare the outcomes associated with chemo-induced amenorrhea between the two neoadjuvant chemotherapies. The investigators will randomly assign 600 premenopausal female patients with operable breast cancer to receive four cycles of docetaxel and epirubicin (TE); or four cycles of docetaxel, epirubicin, and cyclophosphamide (TEC). After every two cycles of neoadjuvant chemotherapy, the investigators will estimate the effectiveness of therapy. Patients will undergo modified radical mastectomy or breast-conserving surgery after four cycles of neoadjuvant chemotherapy, and then receive postoperative chemotherapy (two cycles), radiation therapy, ...
The current study is a multicentre, randomized, open (unblended), prospective clinical trial which is sponsored by the researchers. The trial is designed to compare the effectiveness between docetaxel plus epirubicin, and docetaxel plus epirubicin plus cyclophosphamide as neoadjuvant chemotherapy for operable premenopausal breast cancer patients, and also to compare the outcomes associated with chemo-induced amenorrhea between the two neoadjuvant chemotherapies. The investigators will randomly assign 600 premenopausal female patients with operable breast cancer to receive four cycles of docetaxel and epirubicin (TE); or four cycles of docetaxel, epirubicin, and cyclophosphamide (TEC). After every two cycles of neoadjuvant chemotherapy, the investigators will estimate the effectiveness of therapy. Patients will undergo modified radical mastectomy or breast-conserving surgery after four cycles of neoadjuvant chemotherapy, and then receive postoperative chemotherapy (two cycles), radiation therapy, ...
Endothelial dysfunction, a pathological feature of obesity, can predict the occurrence of cardiovascular disease. The endothelial function was compared in obese, non-obese, and type 2 diabetic women, and the effect of weight loss on endothelial function in obese premenopausal women was also investigated. METHODS: Twenty type 2 diabetes patients, 35 obese and 20 non-obese non-diabetic subjects were recruited. Both the endothelium-dependent vasodilation (EDV) and endothelium-independent vasodilation (EIV) were measured. The body composition, serum lipid, serum adiponectin and resistin were also measured. Weight loss in obese women was obtained by 6 months of calorific restriction, aerobic exercise and medication (sibutramine or orlistat). RESULTS: EDV was significantly impaired in the type 2 diabetes and obese groups compared to the control group (6.0 +/- 1.3% in diabetes group, 6.7 +/- 3.9% in obese group, 12.4 +/- 4.1% in control group, P < 0.01, respectively). The mean weight loss after 6 ...
The association between the polymorphism of the angiotensin-converting enzyme (ACE) gene and breast cancer risk has been extensively studied, however , the studies about the prognostic factors and ACE gene polymorphism are limited in number. Our aims were to analyze the distribution of the insertion/deletion (I/D) polymor-phism of the ACE gene in Turkish premenopausal patients with breast cancer, which is more aggressive than the postmenopausal counterpart, and to assess whether DD genotype is associated with poor prognostic factors. The DD genotype has been shown to be associated with the increased serum and tissue levels of ACE, compared to those in II and ID genotypes. ACE genotypes were determined by polymerase chain reaction in 44 Turkish premenopausal patients with breast cancer and in 46 age-matched healthy premenopausal women. ACE genotypes are distributed in patients and control subjects as follows; DD is respectively. In breast cancer patients, no significant association was observed between
Sclerostin is a secreted Wnt antagonist produced almost exclusively by osteocytes that regulates bone mass. However, there is currently limited information on the determinants of sclerostin in a large population-based study. The main objectives of the present study were to: (1) establish reference normative interval values for serum sclerostin in randomly selected healthy premenopausal women; (2) study the changes in serum sclerostin in relation to age in premenopausal and postmenopausal women and the factors that may influence bone turnover; and (3) determine the effect of menopausal status on serum sclerostin. A total of 1803 women were studied (including [n = 1235] premenopausal, and [n = 568] postmenopausal women, respectively, aged 20 to 79 years). A total of 443 healthy premenopausal women (aged 35 to 45 years) were used to establish reference normative intervals for serum sclerostin. All women studied were medically examined and had their bone mineral density values obtained for the ...
Author: Atuegbu Chidiadi Maryann Department: Chemical Pathology Affiliation: Nnamdi Azikiwe University Awka This study evaluated the effect of one month moderate -to-vigorous intensity physical exercise on the ovarian reserve status, ovulatory status and the serum levels of some minerals in premenopausal female university students. Thirty female subjects aged 19-25 years participated in this study and…
Abdominal adiposity is associated with metabolic and hormonal changes, many of which have been associated with the risk of premenopausal breast cancer. In the study to investigate the association between body fat distribution, assessed in 1993 by self-reported waist circumference, hip circumference, and waist to hip ratio, and the incidence of premenopausal breast cancer in the Nurses Health Study II, by the Harvard School of Public Health, posted in PubMed, indicated that during 426,164 person-years of follow-up from 1993 to 2005, 620 cases of breast cancer were diagnosed among 45,799 women. Hormone receptor status information was available for 84% of the breast cancers. The age-standardized incidence rates of breast cancer were 131 per 100,000 person-years among those in the lowest quintile of waist circumference and 136 per 100,000 person-years among those in the highest quintile. No statistically significant associations were found between waist circumference, hip circumference, or the ...
In this large prospective study, we found evidence of an inverse association between adult BMI and risk of premenopausal breast cancer. Apparent associations between perceived body shape at age 7 and BMI at age 18 and risk, with heavier builds at both ages seemingly being protective, lost their statistical significance after adjustment for adult BMI. Body size at age 18 was moderately correlated with BMI in adulthood. Changes in body size from age 7 or 18 to adulthood did not affect the premenopausal breast cancer risk once BMI at cohort enrolment was taken into account. Height was related to risk in a nonlinear fashion, with a statistically significantly reduced risk only in women shorter than 160 cm as compared with those of normal or tall height. We found weak evidence that the effect of adult BMI was stronger in women who were short and had no family history of breast cancer.. Our finding of a protective effect of adult BMI on premenopausal breast cancer risk is in accordance with a growing ...
TY - JOUR. T1 - Adiponectin and negative mood in healthy premenopausal and postmenopausal women. AU - Adam, Tanja. AU - Schamarek, Imke. AU - Springer, Elizabeth A.. AU - Havel, Peter J. AU - Epel, Elissa E.. PY - 2010/11. Y1 - 2010/11. N2 - Negative mood and stress are associated with cardiovascular and metabolic disease. There are likely many physiological mechanisms underlying the poor health outcomes. The relationship of psychological states (negative mood, life stress, and stress-responsive hormones) and adiponectin, an adipokine that promotes insulin sensitivity, was investigated in two separate studies. The two groups of participants included 52 healthy, premenopausal women, and 63 postmenopausal women with a range of stress levels. The relationship between adiponectin and psychological state (perceived stress and negative mood) was examined cross-sectionally in both groups of participants, but also prospectively (1 year later) in the group of postmenopausal women. In premenopausal women, ...
Among Hispanics, young-adult and current body mass index (BMI) were inversely associated with both ER+PR+ and ER−PR− breast cancer. For ER+PR+ disease, risk was substantially reduced among those with elevated BMI throughout adulthood (OR=0.35, 95% CI=0.19-0.62). Height and height-to-waist ratio were positively associated with ER−PR− breast cancer. After adjustment for current BMI, two-fold increased risks were seen for large waist and hip circumferences, regardless of tumor receptor status. Genetic ancestry appeared to modify some of the associations with overall and abdominal adiposity. Among NHWs, findings for overall adiposity were similar to those for Hispanics, but there was no evidence of associations with abdominal adiposity ...
Heart, bone health and avoiding treatment side effects are top issues for premenopausal breast cancer patients who are HER2/neu positive.
TY - JOUR. T1 - Pre-menopausal and post-menopausal depressed women. AU - Roy, Alec. AU - Linnoila, Markku. AU - Jimerson, David C.. AU - Gold, Philip. AU - Pickar, David. PY - 1986. Y1 - 1986. N2 - In a consecutive series of 28 depressed women, pre-menopausal (n = 13) and post-menopausal (n = 15) patients were compared. Post-menopausal women had significantly higher levels of plasma norepinephrine, plasma 3-methoxy-4-hydroxyphenylglycol, post-dexamethasone plasma cortisol, cerebrospinal fluid 3-methoxy-4-hydroxyphenylglycol and corticotropin-releasing hormone. However, when biologic measures were adjusted for age by analyses of covariance there were no significant differences. Pre-menopausal women had had significantly more life events before the onset of depression than post-menopausal women. The implications of these findings are discussed.. AB - In a consecutive series of 28 depressed women, pre-menopausal (n = 13) and post-menopausal (n = 15) patients were compared. Post-menopausal women had ...
One of the real benefits of this research is that it brings a lot of focus to premenopausal breast cancer, which otherwise wasnt thought much about, said Mahalakshmi Kumaran, Damarajus graduate student, who is the lead author on the paper.. Published in the International Journal of Cancer, the study is the first of its kind to examine breast cancer risk in Caucasian women divided into premenopausal and postmenopausal groupings. Because the majority of breast cancers are diagnosed in women over the age of 55, most genetic association studies focus on postmenopausal women. However, inherited forms of cancers, typically related to genetic mutations, are more likely to be more aggressive and be diagnosed earlier in life.. The researchers examined more than 9,000 women from Alberta, using samples from patients diagnosed with breast cancer and unaffected healthy controls from the Alberta Cancer Research Biobank and the Albertas Tomorrow Project, respectively.. The DNA isolated from the ...
Nutrition: Calcium and vitamin D cut breast cancer risk in pre-menopausal women. No protective effect was observed in post-menopausal women.
Women who avoid red meat are more likely to be at a healthier weight and have lower levels of chronic inflammation and oxidative stress, according to a study published in the British Journal of Nutrition. Researchers analyzed lifestyle and dietary information in an ethnically diverse group of 275 healthy premenopausal women and collected biomarkers of inflammation linked to cancer incidence.. ...
Exposure to air pollution early in life and when a woman gives birth to her first child may alter her DNA and may be associated with premenopausal breast cancer later in life
In summary, our acquiring of quick a single-technology psychological acculturation contributes to a1242156-23-5 growing literature in the evolutionary sciences
Historically, there has been a dearth of information on occupational exposures of women to chemicals and endocrine disruptors and therefore on links between occupational exposures and breast cancer specifically. In November 2012, a landmark paper titled Breast cancer risk in relation to occupations with exposure to carcinogens and endocrine disruptors: a Canadian case-control study was published in the journal Environmental Health. In this groundbreaking study the authors showed that across all sectors, women in jobs with potentially high exposures to carcinogens and endocrine disruptors had elevated breast cancer risk and that premenopausal breast cancer risk was highest for automotive plastics and food canning workers. The two key authors of this study, James Brophy, PhD, and Margaret Keith, PhD, will join Jeanne Rizzo, RN, President and CEO of the Breast Cancer Fund and Charlotte Brody, RN, Associate Director, Health Initiatives, BlueGreen Alliance to discuss this study and its implications ...
Among premenopausal women with early stage, HR-positive breast cancer, the addition of ovarian suppression to tamoxifen reduced breast cancer recurrence.
Fingerprint Dive into the research topics of Preliminary 3-year results of 12 versus 6 cycles of surgical adjuvant CMF in premenopausal breast cancer. Together they form a unique fingerprint. ...
Breastfeeding reduces breast cancer risk among women with a family history of breast cancer, according to a study. Observational studies suggest a relationship between lactation and premenopausal breast cancer risk.
Health,A new study has challenged the ill-effects of obesity as a causative ...Latest research has indicated that having a higher Body Mass Index...The researchers found that a high BMI could result in irregular or...Dr Sarah Cant senior policy and information officer for Breakthro......,Obesity,may,Reduce,Risk,of,Breast,Cancer,in,Pre-menopausal,Women,medicine,medical news today,latest medical news,medical newsletters,current medical news,latest medicine news
(HealthDay)-Across body mass index (BMI) distribution, increased BMI is associated with reduced risk of premenopausal breast cancer, according to a study published online June 21 in JAMA Oncology.
Estrogen inhibition of a key receptor that helps regulate blood pressure may be a new mechanism by which premenopausal women are protected from cardiovascular disease. Abstract The steroid hormone aldosterone (aldo) contributes to cardiovascular disease in animal models and in humans. Aldo activates the mineralocorticoid receptor (MR), a hormone-activated transcription factor, and indeed, pharmacological MR inhibition improves cardiovascular outcomes. Because the incidence of cardiovascular dise
What Your Doctor May Not Tell You About PREmenopause: Balance Your Life and Your Hormones from Thirty to Fifty by John R. Lee, M.D., Jesse Hanley M.D. and Virginia Hopkins
A higher HDL-C level was associated with reduced risk of premenopausal breast cancer. HDL-C ≥ 60 mg/dL decreased breast cancer risk by 0.49-fold (OR, 0.49; 95% CI, 0.33-0.72) compared with HDL-C , 50 mg/dL among premenopausal women. When it was stratified by BMI, however, only in the premenopausal group of BMI , 23.0 kg/m2 was there significant inverse relationship between HDL-C and breast cancer risk (Ptrend , 0.01).. The association between HDL-C and breast cancer risk by menopausal status has been inconsistent among studies (13, 26-33). However, several results show consistent results of our study. In a recent cohort study of 359 cases among 7,575 members, low baseline HDL-C level showed an modest increase of breast cancer only among premenopausal women (hazard ratio, 1.67; 95% CI, 1.06-2.63; ref. 13). In a nested case-control study (33) with 51 incident cases among 5,207 subjects, there was an inverse association between serum HDL-C and breast cancer. The risk was 0.3 (95% CI, 0.1-0.8) for ...
How is breast cancer different in young women than in older women, what unique issues must be faced, and how can you find the support you need?
Supplementary MaterialsSupplement1. The effect of scientific risk was examined by calculating threat ratios for faraway recurrence by using Cox proportional-hazards versions. The original endocrine therapy was tamoxifen by itself in a lot of the premenopausal females who had been 50 years or younger. Outcomes The amount of scientific risk was prognostic of faraway recurrence in females with an intermediate 21-gene recurrence rating of 11 to 25 (on the range of 0 to 100, with higher ratings indicating a worse prognosis or a larger potential reap the benefits of chemotherapy) who had been randomly designated to endocrine therapy (threat proportion for the evaluation of high vs. low scientific risk, 2.73; 95% self-confidence period [CI], 1.93 to 3.87) or even to chemotherapy as well as endocrine (chemoendocrine) therapy (threat proportion, 2.41; 95% CI, 1.66 to 3.48) and in females with a higher recurrence rating (a rating of 26 to 100), most of whom were assigned to chemoendocrine therapy (threat ...
analog of naturally occurring gonadotropin releasing hormone (GnRH or LHRH.) The analog possesses greater potency than the natural hormone. Lupron acts as a potent inhibitor of gonadotropin secretion when given continuously and in therapeutic doses. Following an initial stimulation, chronic administration of Lupron results in suppression of ovarian steroid production. This effect is reversible upon discontinuation of drug therapy. In humans, subcutaneous administration of single daily doses of Lupron results in an initial increase in circulation levels of LH and FSH, leading to a transient increase in levels of the gonadal steroids estrone and estradiol. However, continuous daily administration of Lupron results in decreased levels of LH and FSH. In premenopausal females, estrogens are reduced to post-menopausal levels. These decreases occur within two to four weeks after initiation of treatment. Lupron produces numerous side effects including cardiovascular symptoms like congestive heart ...
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Pagani O, Regan MM, Walley BA, Fleming GF, Collecni M, Láng I, Gomez HL, Tondini C, Burstein HJ, Perez EA, Ciruelos E, Steams V, Bonnefoi HR, Martino S, Geyer Jr CE, Pinotti G, Puglisi F, Crivellari D, Rushtaller T, Winer EP, Rabaglio-Poretti M, Malbach R, Ruepp B, Giobbie-Hurder A, Price KN, Bernhard J, Luo W, Viale G, Coates AS, Gelber RD, Goldhirsch A, Francis PA, for the TEXT and SOFT Investigators and the International Breast Cancer Study Group. Adjuvant exemestane with ovarian suppression in premenopausal breast cancer. N Engl J Med 2014;371:107-18. [Ref.ID 97807 ...
Ribociclib combined with hormone therapy significantly improves PFS in premenopausal patients with HR-positive, HER2-negative breast cancer. Learn more!
A new study found physical activity for premenopausal women is very effective in reducing sclerostin a known inhibitor of bone formation and physical training also improves bone health.
Hi I am pre-menopausal and every two or three months my body feels as if I am going to have a period, I get all the symptoms especially the bloated stomach...
There is evidence for an inverse association between physical activity and breast cancer risk. The evidence is stronger for postmenopausal breast cancer than for premenopausal breast cancer.
Wu and colleagues also take issue with our statement that there was a median decrease (of Ki67) of 0.13% in the postmenopausal-treated group, whereas in premenopausal women, it increased by 0.19%. Our statement is based on results presented in Table 3, in the last column, where the median between-group differences are shown, with their confidence intervals and P values. For postmenopausal women, this between-group change is −0.13 (-0.42 to 0.08), and for premenopausal women, this difference is +0.19 (-0.46 to 1.07).. Finally, Wu and colleagues note that 89% of the soy group was sampled in the luteal phase, compared with 72% of the placebo group, raising a concern about the legitimacy of comparing the soy and placebo group Ki67 results. We gave significant thought to the presentation of the study findings when it became apparent that luteal phase sampling had not been achieved in all premenopausal women and decided that it would be more appropriate to present intent-to-treat data on all ...
Incontinence affects one in four pre-menopausal women and nearly half of post-menopausal women. But its treatable at any age, and treatment is associated with far less morbidity.
Pae C, Mandelli L, Han C, Ham B, Masand P, Patkar A, Steffens D, De Ronchi D, Serretti A. Do estradiol levels influence on the cognitive function during antidepressant treatments in post-menopausal women with major depressive disorder? A comparison with pre-menopausal women. Neuro Endocrinol Lett. 2008 Aug; 29(4): 500-506 ...
Women who breast-feed their babies even for short periods of time may lower their risk of developing premenopausal breast cancer if they have a family history of the disease in Wilmington. We saw a 59 percent lower risk of breast cancer among women with a family history who had ever breast-fed, stated Dr. Alison Stuebe, lead author of a study appearing in the Aug. 10/24 issue of the Archives of Internal Medicine. It is surprising to see this really strong association with a pretty decreased risk ...
Women who breast-feed their babies even for short periods of time may lower their risk of developing premenopausal breast cancer if they have a family history of the disease in Camp Lejeune. We saw a 59 percent lower risk of breast cancer among women with a family history who had ever breast-fed, stated Dr. Alison Stuebe, lead author of a study appearing in the Aug. 10/24 issue of the Archives of Internal Medicine. It is surprising to see this really strong association with a pretty decreased risk ...
TY - JOUR. T1 - Correlation between estrogens and serum adipocytokines in premenopausal and postmenopausal women. AU - Hong, Soon Cheol. AU - Yoo, Sang Wook. AU - Cho, Geum Joon. AU - Kim, Tak. AU - Hur, Jun Young. AU - Park, Yong Kyun. AU - Lee, Kyu Wan. AU - Kim, Sun Haeng. PY - 2007/9. Y1 - 2007/9. N2 - OBJECTIVE: The purpose of this study was to investigate the association between serum adipocytokines (adiponectin, resistin, leptin, and tumor necrosis factor α [TNF-α]) and endogenous estrogen (estrone and estradiol) levels in healthy premenopausal and postmenopausal women. DESIGN: This study included 53 healthy premenopausal women, 45 healthy postmenopausal women, and 10 postmenopausal women with the metabolic syndrome who were participating in general health examinations. A secondary analysis was performed on levels of adiponectin, resistin, leptin, TNF-α, estrone (E1), and estradiol (E2). RESULTS: After accounting for body mass index, TNF-α was significantly increased (1.5 ± 0.1 vs ...
Aim: This study investigates the prognostic value of cyclin E in relation to tumour growth pattern by analysing stage II primary breast cancers from premenopausal women not subjected to any further adjuvant treatment. In addition, the value of cyclin E as a predictor of tamoxifen response was analysed, by comparing untreated and treated patients with oestrogen receptor positive tumours. Methods: Breast cancer samples, assembled in tissue microarrays, were immunohistochemically stained for cyclin E and evaluated regarding the presence of nuclear staining. The overall growth characteristics of each tumour were assessed using whole tissue sections. Results: Tumours displaying a pushing margin phenotype were strongly associated with high cyclin E levels, lymph node negative disease, a high histological grade, ER negativity, and exhibited a better prognosis compared to tumours with an infiltrative growth pattern. In the total cohort of non-treated patients (N=187), cyclin E was not associated with ...
Background. Higher levels of endogenous sex steroid hormones are associated with increased risks of breast cancer in postmenopausal women. Data for premenopausal women are sparse, in part because of the complexity of measuring hormone levels that vary cyclically. We prospectively evaluated associations between plasma sex hormone levels and breast cancer risk among premenopausal women in a case-control study nested within the Nurses Health Study II. Methods: From 1996 to 1999, blood samples were collected from 18 521 premenopausal women during the early follicular and mid-luteal phases of their menstrual cycles. A total of 197 cases of breast cancer were diagnosed among these women after blood collection and before June 1, 2003; these case subjects were matched to 394 control subjects. Logistic regression models, controlling for breast cancer risk factors, were used to calculate relative risks (RRs) and 95% confidence intervals (CIs). All statistical tests were two-sided. Results: Women in the ...
We have characterized four monoclonal antibodies (mAbs) to the purple (tartrate-resistant, band 5) acid phosphatase of the human osteoclast (TRAP) and used these to develop a specific serum immunoassay. All four mAbs are of high affinity (Ka = 1-5 x 10(8) L/mol) with a very fast Kassoc (0.2-2.0 x 10(5) L mol-1 s-1) and a moderate Kdissoc (1-3 x 10(-3) s). Two of the mAbs were selected to develop a time-resolved fluorescence immunoassay to measure serum concentrations of TRAP. The mean serum immunoreactive TRAP in a group of healthy premenopausal women and men was 3.7 +/- 1.8 micrograms/L (mean +/- SD) and 3.5 +/- 1.6 micrograms/L, respectively. Significantly higher concentrations of TRAP were found in postmenopausal women (6.3 +/- 2.3 micrograms/L) and in eight patients with Gaucher disease (19.3 +/- 4.7 micrograms/L). Further studies are required to investigate the value of serum TRAP as a marker of bone resorption.. ...
The objective of this study was to conduct an intervention study to test how low-fat yogurt consumption affects postprandial metabolism, chronic inflammation, and intestinal barrier function. Apparently healthy premenopausal women with body mass index (BMI) of 18.5 to 27 (lean) or 30 to 40 kg/m2 (obese) participated in a 9-week controlled intervention study. Participants in each BMI range were randomly assigned to either a low-fat yogurt-supplemented group (Y, yogurt lean; YO, yogurt obese) or a soy pudding-supplemented control group (C, control lean; CO, control obese), with n = 30/group. Participants consumed 12 oz. of yogurt or the control food daily for 9 weeks while maintaining usual caloric intake. At wk 0, 3, 6 and 9, participants provided fasting blood samples for determination of inflammation and endotoxemia, and for weight and blood pressure measurement. At wk 0 and 9, participants consumed 8 oz. of yogurt or the control food, followed by a high-fat, high-carbohydrate challenge meal. Blood
Prior research suggests that several endogenous hormones in premenopausal women are associated with breast cancer risk; however, few studies have evaluated associations of endogenous hormones with mammographic density (MD) in premenopausal women. We conducted a cross-sectional study of plasma hormone levels in relation to MD among 634 cancer-free premenopausal women in the Nurses Health Study II. We measured percent MD from screening mammograms using a computer-assisted method. We assayed estradiol, estrone, and estrone sulfate in blood samples timed in early follicular and mid-luteal phases of the menstrual cycle as well as testosterone, androstenedione, progesterone, dehydroepiandrosterone (DHEA), DHEA sulfate, sex hormone-binding globulin (SHBG), and anti-Müllerian hormone in luteal or untimed samples ...
Prior research suggests that several endogenous hormones in premenopausal women are associated with breast cancer risk; however, few studies have evaluated associations of endogenous hormones with mammographic density (MD) in premenopausal women. We conducted a cross-sectional study of plasma hormone levels in relation to MD among 634 cancer-free premenopausal women in the Nurses Health Study II. We measured percent MD from screening mammograms using a computer-assisted method. We assayed estradiol, estrone, and estrone sulfate in blood samples timed in early follicular and mid-luteal phases of the menstrual cycle as well as testosterone, androstenedione, progesterone, dehydroepiandrosterone (DHEA), DHEA sulfate, sex hormone-binding globulin (SHBG), and anti-Müllerian hormone in luteal or untimed samples ...
Results: Pre- and post-menopausal women had a median age of 35 (31 to 42) and 57 (52 to 68); body mass index 25 (24 to 28) and 27 (23 to 29), CrCl 86 (58 to 112) and 76 (65 to 104) mL/min, respectively. We enrolled 10 African American and 2 white pre-menopausal women; and 5 African American and 1 Hispanic post-menopausal women. After first dose, blood plasma exposure was similar, but genital tract exposure was increased in post-menopausal women resulting in an increased genital tract : blood plasma ratio. At steady state, post-menopausal women had greater exposure in both blood plasma (p = 0.02) and genital tract (p = 0.01), resulting in similar genital tract : blood plasma ratios. C24h was greater in blood plasma (p = 0.04) and genital tract (p = 0.01) in post-menopausal women at steady state. In post-menopausal women, blood plasma AUC and blood plasma C24h exceed standard pharmacokinetic parameters by 160% and 125%, respectively. ...
There was apparently also some research that says that Zometa helped premenopausal breast cancer patients by making it somewhat less likely that cancer would metastasize to the bone. The reports say by 36%, but it had to do with a study of 1800 patients (I think), in which half got Zometa and half didnt (all were premenopausal, early stage breast cancerpatients). 6% of those on Zometa ended up with bone metastases versus 9% of those who didnt get it. 6% of 900 is 54 patients with Zometa, versus 81 patients without Zometa ...
Between October 2012 and April 2013, a total of 80 premenopausal patients (mean age 38.1±7.1 years; range, 18 to 50 years) with non-specific musculoskeletal symptoms were included in the study. The determination of 25-hydroxyvitamin D3 (25(OH)D3) deficiency was based on a reference value of 25 ng/mL. Patients with deficient serum 25(OH)D3 levels ...
A 2009 systematic review and meta-analysis found that soy consumption by premenopausal females did not affect concentrations of estradiol, estrone, or sex-hormone binding globulin, but did seem to reduce follicle stimulating hormone and luteinizing hormone, and increase the length of menstrual cycles (by an average of just over one day). It was unclear if these changes indicated an estrogenic or anti-estrogenic effect. However, all studies under review were considered at risk for bias. When the numbers were crunched in another way, it appeared that soys seeming effect on follicle stimulating hormone was still significant, but effects on luteinizing hormone and menstrual cycle length were no longer significant. In post-menopausal females, soy consumption did not seem to have any effect on any of these hormones; in peri-menopausal females, much less research had been done but there also did not seem to be significant effects on hormone levels (Hooper ...
Endogenous reproductive hormones and oxidative stress have been independently linked to risk of chronic disease but mostly in postmenopausal women. The interplay between endogenous reproductive hormones and oxidative stress among premenopausal women,
Metastatic Breast Cancer:. Premenopausal Women (Tamoxifen vs. Ablation): Three prospective, randomized studies (Ingle, Pritchard, Buchanan) compared tamoxifen to ovarian ablation (oophorectomy or ovarian irradiation) in premenopausal women with advanced breast cancer. Although the objective response rate, time to treatment failure, and survival were similar with both treatments, the limited patient accrual prevented a demonstration of equivalence. In an overview analysis of survival data from the 3 studies, the hazard ratio for death (tamoxifen/ovarian ablation) was 1.00 with two-sided 95% confidence intervals of 0.73 to 1.37. Elevated serum and plasma estrogens have been observed in premenopausal women receiving tamoxifen, but the data from the randomized studies do not suggest an adverse effect of this increase. A limited number of premenopausal patients with disease progression during tamoxifen therapy responded to subsequent ovarian ablation.. Male Breast Cancer: Published results from 122 ...
TY - JOUR. T1 - A standardized exercise intervention differentially affects premenopausal and postmenopausal African-American women. AU - Kretzschmar, Jan. AU - Babbitt, Dianne M.. AU - Diaz, Keith M.. AU - Feairheller, Deborah L.. AU - Sturgeon, Kathleen M.. AU - Perkins, Amanda M.. AU - Veerabhadrappa, Praveen. AU - Williamson, Sheara T.. AU - Ling, Chenyi. AU - Lee, Hojun. AU - Grimm, Heather. AU - Thakkar, Sunny R.. AU - Crabbe, Deborah L.. AU - Kashem, Mohammed A.. AU - Brown, Michael D.. PY - 2014/6. Y1 - 2014/6. N2 - OBJECTIVE: African-American women represent an understudied population in menopause research yet face greater postmenopausal challenges associated with mortality than their white peers. We investigated the effects of a mild-intensity aerobic exercise training program on markers of mortality risk in both premenopausal and postmenopausal African-American women. METHODS: Sixteen premenopausal women and 19 postmenopausal women underwent 6 months of mild-intensity aerobic exercise ...
8. Male subjects, their female partner(s), and female subjects of childbearing potential must agree to use 2 forms of contraception, 1 of which must be a barrier method, during the study and for 90 days after study drug administration. Acceptable barrier forms of contraception are condom and diaphragm. Acceptable forms of contraception for this study for female partner(s) of childbearing potential and premenopausal female subjects are nonhormonal and hormonal intrauterine device (IUD), hormonal birth control pills, hormonal birth control patches, hormonal birth control injections [eg, Depo-Provera(R)], hormonal birth control implants, and NuvaRing(R). Male and female subjects who consider themselves abstinent, and who agree to remain abstinent during the study and for 90 days after study drug administration, will be eligible to participate in the study. Women of nonchildbearing potential are eligible for the study and are defined as 12 months with no menses before screening and a ...
Background: Acute coronary syndromes in premenopausal women isuncommon and limited data is available regarding their risk factor profile and angiographic characteristics.Objectives: To determine the clinical and angiographic findings inpremenopausal women presented with acute coronary syndromes.Patients and methods:Cross sectional study included 160 patients (68premenopausal women and 92 age matched male controls) who were admitted in the coronary care unit of Ibn Al-Betar Center for Cardiac Disease and diagnosed as a cases of acute coronary syndromes between September, 2013 and June, 2014 . The clinical characteristics, angiographic findings for premenopausal women were compared to age matched males.Results: Hypertension was the commonest risk factor for coronary artery disease in both premenopausal women (54.4%) and age matched males (43.5%). The prevalence of smoking was significantly lower in premenopausal women compared with age matched males (8.8% vs 63.0%, p=0.0001). There was no clear ...
Introduction : Osteoporosis is a systemic skeletal disease characterized by low bone mass and destruction of microarchitecture bone tissue. There are 200 million people with osteoporosis in the world (A Rachman, 2007). Osteoporosis happens in women as much as 90%, whereas in males 41.8% (Puslitbang Gizi Depkes RI tahun 2006). The number of people with osteoporosis in Indonesia is much bigger than the last data Depkes, which pegged the figure of 19.7% of the total population. Purpose : To know the knowledge level and attitude towards osteoporosis and kalsuim intake of premenopausal women in the District of Medan Selayang II. Methods : A cross sectional descriptive study were conducted using questionnaires which are distributed to respondents to collect data. Samples were taken by measure of a non-probability Purposive Sampling technique and has to meet the inclusive and exclusive criterias. The datas were later processed by using the computer with Statistical Package for the Social Sciences ...
The Molecular and Cardiovascular Physiology Lab at is looking at how heart disease risk changes during the menopausal transition and is seeking premenopausal women who are 40 years old or older.. If you have been exercising regularly for the past two years, and do not have cardiovascular disease, you may qualify.. This study will provide you with information on your blood lipid levels, glucose levels, cardiovascular fitness, bone mineral density and body composition. You may also win a $50 gift card to a local business, a gym membership or personal training sessions.. You will be asked to come to campus three times for approximately 1-3 hours per visit. During the visits you will be asked to complete studies of blood vessel health using an ultrasound and Doppler machine and to undergo blood draws at rest and before and after exercise. You will complete a maximal exercise test and an acute bout of exercise.. If interested, email [email protected] or call 413/577-0392.. ...
Perimenopause? What?! Im way too young! If youre suddenly struggling with weight gain, insomnia, irregular bleeding or flooding, mood swings, and relationship challenges, perimenopause may be knocking at your door. And theres more! Burning tongue, itchy skin, electric shock feelings? Yes, these can be part of perimenopause too. Women are inundated with information on how to have healthy, happy pregnancies, but we get left out on the opposite end of the reproductive spectrum. That stops now! In this entertaining, information-packed, empowering book, Dr. Anna Garrett shares everything you need to know about your body and how to care for it to create hormone harmony. Here are just a few of the things youll learn: Perimenopause can start as young as 35 Why perimenopause is very different from menopause How you CAN balance your hormones and find symptom relief Why youre not going crazy Tips for creating a healthcare team that gets you the care you deserve Dr. Anna offers realistic, holistic ...
Perimenopause begins several years before menopause (the end of menstruation) and ends a year after the last menstrual period. During this transition, ovarian…
Menopause is a transition period that may last from several months up to a few years. Misinformation about this topic instills fear in many women as they enter their forties and begin to think about menopause. A good example of this is Western medicines focuses on menopause as a disease that must be treated with . . . Read More ». ...
Inclusion Criteria: 1. Female patients over 18 years of age. 2. Pre-menopausal women provided they are being treated with a LHRH analogue for at least 28 days (if shorter, post-menopausal levels of serum estradiol/Follicle-stimulating hormone (FSH) must be confirmed analytically) prior to study entry or post- menopausal women as defined by any of the following criteria: 1. Age ≥60 years; 2. Age ,60 years and cessation of regular menses for at least 12 consecutive months with no alternative pathological or physiological cause; and serum estradiol and/or FSH level within the laboratorys reference range for postmenopausal females; 3. Documented bilateral oophorectomy. 3. Eastern Cooperative Oncology Group (ECOG) performance status lower or equal to 1. 4. Life expectancy greater or equal to 12 weeks. 5. Histologically proven diagnosed of ABC not amenable to curative treatment. 6. Documented recurrent ER-positive and/or progesterone receptor (PgR)-positive (with ≥1% positive stained cells ...
Foods high in iron list of foods high in iron, and for men and post-menopausal women, for men you will need about 10 milligrams of iron daily, and pre-menopausal women need 15 milligrams. Its not a large number, but it is a very important mineral. Iron is a mineral that is required for the transport … Continue reading. ...
The 40s is a time for big changes, especially women who are in the beginning stages of menopause. There is a myth that a womans facelift results can be affected by the hormonal changes of menopause, making it wise to wait until after this transition has completed. The good news is that there are plenty of facelifts performed on pre-menopausal women that result in long-lasting anti-aging effects. You can plan your facelift surgery on your own terms and leave the internal changes of your body for your primary care physician to worry about.. While the aging effects are not as dramatic or obvious in 40-something patients, the differences made by a facelift surgery can still be meaningful. Patients in this age group, both male and female, can benefit from the changes in their contour and profile. Its a great way to set back the clock before some of the more drastic aging signs have begun to affect the face. Remember that every patient is unique, so your aging process will be yours alone. Consult ...
A study funded by the National Dairy Council shows healthy, pre-menopausal women who consumed low-fat yogurt before meals reduced their risk for inflammation following the meal.
This article is in response to Jugdaohsingh et al.: The silicon supplement Monomethylsilanetriol is safe and increases the body pool of silicon in healthy Pre-menopausal women. Nutrition & Metabolism 2013 10:37: http://www.nutritionandmetabolism.com/content/10/1/37 The response from the authors is published as Jugdaohsingh et al.: Response to Prof D. Vanden Berghe ...
NEW STUDY INDICATES THAT PEOPLE MAY NEED MORE DIETARY CHOLINE THAN PREVIOUSLY THOUGHT Eggs One of the Best Sources of the Nutrient Washington, D.C. (May 23, 2007) A new study published in the May issue of the American Journal of Clinical Nutrition indicates that the current recommended Adequate Intake (AI) for choline may, in fact, be inadequate for some people. [1] Choline is an essential nutrient for normal functioning of all cells, including those involved with liver metabolism, brain and nerve function, memory, and the transportation of nutrients throughout the body. In this depletion-repletion study, 57 adult subjects (26 men, 16 premenopausal women and 15 postmenopausal women) were fed a diet containing 550 mg of choline for 10 days, then fed less than 50 mg a day of choline for up to 42 days. When deprived of the nutrient, 77 percent of men, 80 percent of postmenopausal women and 44 percent of premenopausal women developed fatty liver or muscle damage. Six men (23 percent) developed these ...
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Introduksi a. Definisi Suatu tindakan pembedahan dengan cara mengangkat ovarium kanan dan kiri sebagai bagian dari terapi hormonal kanker payudara b. Ruang lingkup Kelenjar ovarium kanan dan kiri c. Indikasi operasi Wanita premenopause dengan kanker payudara stadium lanjut lokal atau lanjut jauh yang pada pemeriksaan imunohistokimia menunjukkan hasil reseptor hormonal yang positif (ER dan atau…
Premenopause[edit]. Premenopause is a term used to mean the years leading up to the last period, when the levels of ... Birkhaeuser M, Genazzani AR (30 January 2018). Pre-Menopause, Menopause and Beyond: Volume 5: Frontiers in Gynecological ... During perimenopause, estrogen levels average about 20-30% higher than during premenopause, often with wide fluctuations.[64] ... Premenopause starts some time before the monthly cycles become noticeably irregular in timing.[60] ...
PremenopauseEdit. Premenopause is a term used to mean the years leading up to the last period, when the levels of reproductive ... During perimenopause, estrogen levels average about 20-30% higher than during premenopause, often with wide fluctuations.[60] ... hormones are becoming more variable and lower, and the effects of hormone withdrawal are present.[42] Premenopause starts some ...
Donnez, J. (2011). "Menometrorrhagia during the premenopause: An overview". Gynecological Endocrinology. 27: 1114-1119. doi: ... "Current and future medical treatments for menometrorrhagia during the premenopause". Gynecological Endocrinology. 27 ( ...
The medical management of menopause and premenopause: their endocrinologic basis. Lippincott Williams & Wilkins. p. 31. ISBN ...
All care after childbirth recovery is typically excluded, which includes pre-menopause and aging into old age. During ...
A lot of women also begin the pre-menopause stage at this time, and many men experience the 'male menopause'. Permanent and ...
This idea fit his observation that it more common for women in menopause and pre-menopause to develop breast lesions. Unlike ...
Estrogen produced pre-menopause has a dampening effect on dopamine receptors but its protection can be overridden by a genetic ...
... whereas the risk of this type of progression in premenopause females increases with an increase in the number of different ...
... premenopause MeSH G08.520.960.374 - puberty MeSH G08.520.960.374.204 - adrenarche MeSH G08.520.960.374.410 - menarche MeSH ...
停經前期(Premenopause)是從生殖激素水平開始降低,開始出現生殖激素不
... mencatat tidak adanya hal ini pada pria yang dikebiri dan wanita premenopause.[49][53] Aulus Cornelius Celsus (30 M) ...
... nggarisi ilange lelara iki ing wong lanang kang dadi kasim lan wanita ing mangsa sadurungé menopause utawa premenopause.[49][53 ...
pre-menopause Hi I am 37, have no children, not on the pill or anything. Every month my periods is 28 days apart. The first ...
Premenopause vs. perimenopause. Share on Pinterest. Premenopause can describe when a woman is experiencing normal periods. ... Premenopause symptoms. While hormone levels fluctuate naturally during premenopause, a woman is unlikely to have symptoms ... Premenopause management. Managing premenopause involves alleviating the symptoms of PMS. This can include taking over-the- ... Technically, premenopause lasts from when a woman has her first period to when she gets her final period and enters menopause. ...
Signs of the premenopause Your ovaries are producing fewer hormones than before but this is accelerated during this stage. ... Premenopause This is the second stage in the menopause process which occurs after the perimenopause. ... There are steps you can take to ease the symptoms of the premenopause. These include a few self help actions such as a healthy ... Once the symptoms of the premenopause become apparent it means that the menopause is on its way. ...
You can have symptom premenopause in your 30s, why you have these symptoms, effective natural treatments, HRT risks, womens ... Wild Salmon, omega-3 and benefits for symptom premenopause.. What are some of the premenopause symptoms?. What are ... Symptom premenopause can begin as early as in a womans 30s or 40s. This is caused by the increasing number of women in the ... review the womens health book selection for treating naturally symptom premenopause and symptoms of premenopause. ...
... Perimenopause is the phase before menopause actually takes place, when ovarian hormone production ...
What Age Is Too Young to Have Pre-Menopause Symptoms? What Age Is Too Young to Have Pre-Menopause Symptoms? ...
12 Studies found for: Recruiting, Not yet recruiting, Available Studies , Premenopause. Also searched for Perimenopause. See ...
"Premenopause" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical Subject ... This graph shows the total number of publications written about "Premenopause" by people in Harvard Catalyst Profiles by year, ... Below are the most recent publications written about "Premenopause" by people in Profiles. ... and whether "Premenopause" was a major or minor topic of these publication. ...
John Lee, M.D. Click here to read Chapter 1: Premenopause As a Life Cycle ... We call this pre-menopause rather than using the medical term peri-menopause, because premenopause syndrome can begin as early ... Some 50 million women are going through premenopause right now, and most of them have experienced some form of premenopause ... WHAT YOUR DOCTOR MAY NOT TELL YOU ABOUT PREMENOPAUSE. How to Balance Your Hormones and Your Life from Thirty to Fifty ...
Major depression more likely during perimenopause than during premenopause. Published: June, 2011 ...
Premenopause is the first stage of menopause when hormones are at stable levels, the time before menopause symptoms appear. ... Premenopause Tests. Women can order a series of tests to determine if she is still in premenopause, or if the typical hormonal ... Premenopause Age. It is hard to tell exactly how long premenopause will last. It begins when a girl has her first period and ... Premenopause vs. Perimenopause. For people who are not familiar with the terms premenopause and perimenopause, they can be very ...
Peri (or Pre-) Menopause. For those of you who are just beginning this wonderful process, here we can narrow down the symptoms ...
CHR specializes in the research and diagnosis and treatment of early menopause, premature menopause and early-onset pre-menopause, with revolutionary DHEA protocols developed by CHR physicians.
What Your Doctor May Not Tell You About PREmenopause: Balance Your Life and Your Hormones from Thirty to Fifty by John R. Lee, ... Premenopause Book Chapter 1. Excerpts from Chapter One of What Your Doctor May Not Tell You About PREmenopause, by John R. Lee ... What Your Dr May Not Tell You about PREmenopause. FINALLY! UNDERSTAND YOUR HORMONES AND SYMPTOMS ... Hanley adds a new dimension to this book by addressing the emotional side of premenopause issues usch as PMS, as well as the ...
Premenopause. This normal life phase extends from age 20 until the changes of perimenopause. -our horizons now extend well ...
pre menopause by: Anonymous I agree in part with the previous comment about vitamin D3 and magnesium, but there is never a set ... Comments for pre menopause or menopause severe low back , pelvic pain. Click here to add your own comments ... pre menopause or menopause severe low back , pelvic pain. by wilma (south africa) ...
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Return to Pre-menopause but want to get pregnant.. Join in and write your own page! Its easy to do. How? Simply click here to ...
I have been to many doctors for the last three years trying to figure out why I started getting symptoms of pre-menopause at ... Jesse Hanley, MD, adds sensitivity to the emotional and spiritual aspects of premenopause. The authors recommend natural ... The book presents common symptoms of premenopause with suggested natural treatments (progesterone cream, diet, vitamins, and ... say the authors of What Your Doctor May Not Tell You About Pre-Menopause. ...
In truth, various females start pre-menopause in their late 30s or early 40s. Pre-menopause symptoms are more severe in ... Learning about pre-Menopause Symptoms. Health And Fitness / By Josh Perez / 17 January 2020 20 January 2020 ... Pre-menopause symptoms are a flawless method to intently bring a females happiness and fun to a stop. Suddenly, an expansion ... Pre-menopause symptoms brought about by a decline in the estrogen level include a decrease in the good cholesterol (HDL) as ...
annotations (the reliablity of the annotated protein expression using immunohistochemically (IH) stained on human tissues, the reliablity of the annotated protein expression in immunofluorescently (IF) stained human cell lines, tissue specificity (the distribution of antibody staining or protein expression in human cell types), cell line specificity (the distribution of RNA abundance in cell lines) and subcellular location (based on immunofluorescent staining of cell lines ...
Premenopause solutions. Premenopause and menopause is a part of life and is a completely natural phase to go through and it ... All of the above are the most regular and frequent problems reported in most women going through premenopause.. Premenopause is ... Menopause occurs in three main stages premenopause, menopause and post-menopause. Premenopause in particular is the hardest ... Premenopause Symptoms. * Most common is the onslaught of hot flashes when you body temperature rises drastically all over your ...
During premenopause you still have a period. Only the period has changed from what your period used to be during your 20s and ... Premenopause is defined as a period of time before menopause. The word Pre means before in Latin. So basically anything that ... It includes premenopause as well as early menopause. Literally in Latin the word Peri means around so anything that happens ... During perimenopause or premenopause, when your hormone equilibrium is off, you may want to consider bioidentical hormones to ...
Understand what premenopause is and what differences there are between premature and premenopause. ... Premenopause is refered to the entirety of a womans life from the first to her last regular menstrual period. ... premenopause , premenopause signs and symptoms , premenopause treatment , premenopause symptoms ©Copyright 2008. Premenopause. ... Premenopause. The term premenopause refers to the entirety of a womans life from the first to her last regular menstrual ...
What Your Doctor May Not Tell You About Premenopause: Balance Your Hormones and Your Life From Thirty to Fifty by John R. Lee, ... What Your Doctor May Not Tell You About Premenopause: Balance Your Hormones and Your Life From Thirty to Fifty by John R. Lee, ... A safe, effective hormone balance program for women aged 30-50 suffering from premenopause syndrome. Restore and maintain ...
44 yrs, pre-menopause. weight loss (almost 20 lbs in 2 months) fatigue, appetite loss. ct scan revealed bilateral adnexal cysts ... 44 yrs, pre-menopause. weight loss, fatigue, appetite loss. CT scan revealed bilateral adnexal cysts, enlarged uterus, pelvic ...
Premenopause is not associated with a change in the smell of urine. This can happen due to decreased fluid intake. A urine ... Does pre menopause cause urine to smell offensive?. I am 46 years old and had a partial hysterectomy at 33 years. I have had 6 ... Premenopause is not associated with a change in the smell of urine. This can happen due to decreased fluid intake. A urine ... Hello, Premenopause is not associated with a change in the smell of urine. This can happen due to decreased fluid intake. A ...
Perimenopause, the time before menopause begins, can be characterized by hot flashes, weight gain, and mood swings. As these symptoms are caused by hormone fluctuations, they may be relieved by bioidentical hormone replacement therapy, which is available in Lakeland, FL.
Perimenopause, the time before menopause begins, can be characterized by hot flashes, weight gain, and mood swings. As these symptoms are caused by hormone fluctuations, they may be relieved by bioidentical hormone replacement therapy, which is available in Des Plaines, IL.
Premenopause[edit]. Premenopause is a term used to mean the years leading up to the last period, when the levels of ... Birkhaeuser M, Genazzani AR (30 January 2018). Pre-Menopause, Menopause and Beyond: Volume 5: Frontiers in Gynecological ... During perimenopause, estrogen levels average about 20-30% higher than during premenopause, often with wide fluctuations.[64] ... Premenopause starts some time before the monthly cycles become noticeably irregular in timing.[60] ...
  • Total Balance Women's Premium has high-potency extracts that support the balancing of female hormones for symptom premenopause, menopause and postmenopause. (safemenopausesolutions.com)
  • According to www.Menopause-Natural.com , there are four stages of menopause: premenopause, perimenopause, menopause and postmenopause. (massagemag.com)
  • CONCLUSIONS: Smoking, diabetes, depression and systolic blood pressure are predictors of coronary artery disease in middle-aged women at premenopause, postmenopause and after undergoing hysterectomy respectively. (elsevier.com)
  • These are premenopause, perimenopause and postmenopause. (lansingstatejournal.com)
  • Premenopause and perimenopause are similar terms that are sometimes used in place of each other. (medicalnewstoday.com)
  • In this section, women can find information about the differences between premenopause and perimenopause, the average age range in which premenopause manifests in women, and the various tests they may choose to undergo to identify premenopause. (34-menopause-symptoms.com)
  • For people who are not familiar with the terms premenopause and perimenopause, they can be very confusing. (34-menopause-symptoms.com)
  • Excerpts from Chapter One of What Your Doctor May Not Tell You About PREmenopause, by John R. Lee, M.D. and Virginia Hopkins, including why you might recognize your hormone imbalance symptoms in this book if you're between the ages of thirty and fifty, and why you can look forward to perimenopause and menopause. (virginiahopkinstestkits.com)
  • What is the Difference between Premenopause and Perimenopause? (hotzehwc.com)
  • I don't want to disparage the concept of belonging, but I do want you to understand that the labels of Premenopause and Perimenopause are not something you need to enhance your life. (hotzehwc.com)
  • First, I'd like to eliminate the confusion surrounding the terms Premenopause and Perimenopause. (hotzehwc.com)
  • During perimenopause or premenopause, when your hormone equilibrium is off, you may want to consider bioidentical hormones to help you feel in better balance. (hotzehwc.com)
  • Therefore, premenopause is best defined as a time of "normal" reproductive function in a woman leading into the stage of menopause called perimenopause . (menopause-faq.com)
  • Most women go through premenopause and perimenopause stages before they reach menopause. (safemenopausesolutions.com)
  • Excerpted from What Your Doctor May Not Tell You about PREmenopause by Dr. John Lee and Virginia Hopkins. (virginiahopkinstestkits.com)
  • A woman's life is full of confusing menopausal phases that all have their own unique definitions.Should now be clear what the differences are between early menopause and premenopause. (34-menopause-symptoms.com)
  • The term premenopause refers to the entirety of a woman's life from the first to her last regular menstrual period. (menopause-faq.com)
  • Premenopause refers to the time in a woman's life where she is having normal menstrual cycles and not suffering from hot flashes, night sweats or any other symptoms. (drdianahoppe.com)
  • In order to understand what happens to a woman's reproductive system as she grows older, it is helpful to review the "normal" reproductive function during premenopause, which helps a woman's body to prepare for the possibility of pregnancy each month. (menopause-faq.com)
  • Pre menopause age or premenopause age - most women begin to experience some type of gradual slowdown of their reproductive cycle resulting in premenopause symptoms and health issues somewhere between their early 30's to their 40's. (safemenopausesolutions.com)
  • What is a symptom premenopause? (safemenopausesolutions.com)
  • Symptom premenopause can begin as early as in a woman's 30's or 40's. (safemenopausesolutions.com)
  • Womens Health Bookstore - review the women's health book selection for treating naturally symptom premenopause and symptoms of premenopause. (safemenopausesolutions.com)
  • But more important is the question - why does a symptom premenopause begin? (safemenopausesolutions.com)
  • As a result, their hormonal balance can begin to change and get out of balance, resulting in having a symptom premenopause. (safemenopausesolutions.com)
  • And without ovulation, your body does not produce progesterone , and most women seem unaware that the LACK OF PROGESTERONE can cause a symptom premenopause. (safemenopausesolutions.com)
  • Here are recommended supplements for symptom premenopause. (safemenopausesolutions.com)
  • If you are experiencing a symptom premenopause, consider using 'Total Balance' Women's Premium and natural progesterone cream to balance your hormones and to help relieve your symptoms of premenopause. (safemenopausesolutions.com)
  • The body's production of estrogen can also vary - too high or too low - resulting in a symptom premenopause such as breast swelling and tenderness and sleep disturbances. (safemenopausesolutions.com)
  • What is a Symptom Premenopause and What To Do? (safemenopausesolutions.com)
  • Balance your hormones yourself for your symptoms of premenopause! (safemenopausesolutions.com)
  • In spite of what a conventional doctor will tell you, you can do something about the symptoms of premenopause besides antidepressant drugs, synthetic hormones, and surgery. (johnleemd.com)
  • It is the balance and interplay between these hormones which regulate the specific events of a "normal" menstrual cycle during premenopause. (menopause-faq.com)
  • And when thee hormones are not in balance, premenopause and premature menopause symptoms in women are the result. (safemenopausesolutions.com)
  • These symptoms are part of premenopause for a majority of today's women, and are the result of hormone imbalances, most of them caused by an excess of the hormone estrogen, and a deficiency of the hormone progesterone. (johnleemd.com)
  • While hormone levels fluctuate naturally during premenopause, a woman is unlikely to have symptoms related to a loss of estrogen. (medicalnewstoday.com)
  • A safe, effective hormone balance program for women aged 30-50 suffering from premenopause syndrome. (artemisiabotanicals.com)
  • Over 50 million women experience premenopause symptoms, including: Unexplained, sudden weight gain Severe PMS, fatigue, irritability, and mood swings Loss of libido Tender or lumpy breasts Fibroids and endometriosis Cold hands and feet Very heavy or light periods Or other symptoms like infertility, memory loss, and migraines. (nwcbooks.com)
  • Women who have reached the age of premenopause could benefit a great deal by taking a quality multiple vitamin/mineral supplement. (safemenopausesolutions.com)
  • Premenopause is a phenomenon that all women know about, but very few have a name for. (johnleemd.com)
  • Some 50 million women are going through premenopause right now, and most of them have experienced some form of premenopause syndrome, a collection of symptoms experienced by women for ten to twenty years before menopause. (johnleemd.com)
  • During premenopause, many women experience bodily discomforts, commonly known as premenstrual syndrome (PMS). (34-menopause-symptoms.com)
  • Women can order a series of tests to determine if she is still in premenopause, or if the typical hormonal changes related to menopause have already started. (34-menopause-symptoms.com)
  • Women may mistake symptoms of pregnancy for premenopause, so it is important to determine the actual cause of the symptoms. (34-menopause-symptoms.com)
  • Like a pregnancy test, women who are experiencing these symptoms might also want to rule out the possibility of an underlying thyroid problem , rather than premenopause symptoms. (34-menopause-symptoms.com)
  • After understanding what premenopause is, the age range it lasts for most women, and some tests to identify potential problems, the next step is to learn the causes behind premenopause. (34-menopause-symptoms.com)
  • For women in the premenopause stage, weight gain and general fitness can often become an issue associated with this period in their life. (34-menopause-symptoms.com)
  • Premenopause in particular is the hardest women go through, as there are various stages within the first stage! (natural-progesterone-estrogen-supplements.com)
  • As noted before not all women experience these stages and not all experiences are the same for women in Premenopause and can experience various degrees of it. (natural-progesterone-estrogen-supplements.com)
  • Anemia is shown to occur a lot in women going through premenopause as blood levels drop drastically as the body slows down in the production of iron in the blood. (natural-progesterone-estrogen-supplements.com)
  • All of the above are the most regular and frequent problems reported in most women going through premenopause . (natural-progesterone-estrogen-supplements.com)
  • A double blind randomized clinical trial was conducted in 77 premenopause overweight or obese women. (clinicaltrials.gov)
  • Premenopause is often misused to mean premature menopause , a relatively rare phenomenon in which menopause occurs before the age of 40. (menopause-faq.com)
  • Hormonal changes during premenopause can make you stressed and cause sleep problems . (brightside.me)
  • Premenopause can describe when a woman is experiencing normal periods. (medicalnewstoday.com)
  • Instead, a woman in premenopause will usually have regular or semi-regular periods, be fertile, and may experience symptoms of premenstrual syndrome (PMS). (medicalnewstoday.com)
  • periods, you are in premenopause. (nccn.org)
  • Tujuan Penelitian : Untuk mengetahui tingkat pengetahuan tentang dan sikap terhadap osteoporosis dan asupan kalsuim wanita premenopause di Kecamatan Medan Selayang II. (usu.ac.id)
  • Hasil penelitian : Pengetahuan wanita - wanita premenopause di Kecamatan Medan Selayang II terhadap osteoporosis kategori baik sebanyak 87 responden (8 %), sedang sebanyak 13 responden (13%) dan kurang tidak ditemukan. (usu.ac.id)
  • Kesimpulan dan saranan : Tingkat pengetahuan tentang osteoporosis dan kalsium wanita premenopause di Kecamatan Medan Selayang II dalam kategori baik tetapi sikap dalam kategori sedang. (usu.ac.id)
  • Technically, premenopause lasts from when a woman has her first period to when she gets her final period and enters menopause. (medicalnewstoday.com)
  • It's premenopause syndrome, which is not a natural or inevitable part of life, but one created by our culture, lifestyles and environment. (johnleemd.com)
  • We call this pre-menopause rather than using the medical term peri-menopause, because premenopause syndrome can begin as early as the mid-thirties, while peri-menopause technically means "right around menopause," meaning the year or two before, during and after menstrual cycles end. (johnleemd.com)
  • Now Dr. John Lee-author of the groundbreaking What Your Doctor May Not Tell You About Menopause -teams up with women's health expert Jesse Hanley, M.D., to bring you a revolutionary nonprescription "Balance Program" with simple, safe, and natural solutions for premenopause. (artemisiabotanicals.com)
  • There are steps you can take to ease the symptoms of the premenopause. (medic8.com)
  • It includes premenopause as well as early menopause. (hotzehwc.com)
  • Menopause Support - what can I take for premenopause systoms? (drugs.com)
  • This graph shows the total number of publications written about "Premenopause" by people in Harvard Catalyst Profiles by year, and whether "Premenopause" was a major or minor topic of these publication. (harvard.edu)
  • Many case histories are included, and Dr. Hanley adds a new dimension to this book by addressing the emotional side of premenopause issues usch as PMS, as well as the use of herbs and nutritional supplements to treat symptoms. (virginiahopkinstestkits.com)
  • Download Book What Your Dr Premenopause in PDF format. (nwcbooks.com)