A synthetic anti-inflammatory glucocorticoid derived from CORTISONE. It is biologically inert and converted to PREDNISOLONE in the liver.
Solid dosage forms, of varying weight, size, and shape, which may be molded or compressed, and which contain a medicinal substance in pure or diluted form. (Dorland, 28th ed)
A group of CORTICOSTEROIDS that affect carbohydrate metabolism (GLUCONEOGENESIS, liver glycogen deposition, elevation of BLOOD SUGAR), inhibit ADRENOCORTICOTROPIC HORMONE secretion, and possess pronounced anti-inflammatory activity. They also play a role in fat and protein metabolism, maintenance of arterial blood pressure, alteration of the connective tissue response to injury, reduction in the number of circulating lymphocytes, and functioning of the central nervous system.
Agents that suppress immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-CELLS or by inhibiting the activation of HELPER CELLS. While immunosuppression has been brought about in the past primarily to prevent rejection of transplanted organs, new applications involving mediation of the effects of INTERLEUKINS and other CYTOKINES are emerging.
A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys, and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow.
Tablets coated with material that delays release of the medication until after they leave the stomach. (Dorland, 28th ed)
An antitumor alkaloid isolated from VINCA ROSEA. (Merck, 11th ed.)
Chemistry dealing with the composition and preparation of agents having PHARMACOLOGIC ACTIONS or diagnostic use.
Usually inert substances added to a prescription in order to provide suitable consistency to the dosage form. These include binders, matrix, base or diluent in pills, tablets, creams, salves, etc.
Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the LIVER to form the active aldophosphamide. It has been used in the treatment of LYMPHOMA and LEUKEMIA. Its side effect, ALOPECIA, has been used for defleecing sheep. Cyclophosphamide may also cause sterility, birth defects, mutations, and cancer.
The preparation, mixing, and assembling of a drug. (From Remington, The Science and Practice of Pharmacy, 19th ed, p1814)
The giving of drugs, chemicals, or other substances by mouth.
Dosage forms of a drug that act over a period of time by controlled-release processes or technology.
Antineoplastic antibiotic obtained from Streptomyces peucetius. It is a hydroxy derivative of DAUNORUBICIN.
The use of two or more chemicals simultaneously or sequentially in the drug therapy of neoplasms. The drugs need not be in the same dosage form.
The application of scientific knowledge or technology to pharmacy and the pharmaceutical industry. It includes methods, techniques, and instrumentation in the manufacture, preparation, compounding, dispensing, packaging, and storing of drugs and other preparations used in diagnostic and determinative procedures, and in the treatment of patients.
Time schedule for administration of a drug in order to achieve optimum effectiveness and convenience.
An antineoplastic agent used primarily in combination with mechlorethamine, vincristine, and prednisone (the MOPP protocol) in the treatment of Hodgkin's disease.
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
Methylester of cellulose. Methylcellulose is used as an emulsifying and suspending agent in cosmetics, pharmaceutics and the chemical industry. It is used therapeutically as a bulk laxative.
A glucocorticoid with the general properties of the corticosteroids. It is the drug of choice for all conditions in which routine systemic corticosteroid therapy is indicated, except adrenal deficiency states.
A biologic alkylating agent that exerts its cytotoxic effects by forming DNA ADDUCTS and DNA interstrand crosslinks, thereby inhibiting rapidly proliferating cells. The hydrochloride is an antineoplastic agent used to treat HODGKIN DISEASE and LYMPHOMA.
Substances made up of an aggregation of small particles, as that obtained by grinding or trituration of a solid drug. In pharmacy it is a form in which substances are administered. (From Dorland, 28th ed)
An immunosuppressive agent used in combination with cyclophosphamide and hydroxychloroquine in the treatment of rheumatoid arthritis. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), this substance has been listed as a known carcinogen. (Merck Index, 11th ed)
Therapy with two or more separate preparations given for a combined effect.
The ability of a substance to be dissolved, i.e. to form a solution with another substance. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)
An alkylating nitrogen mustard that is used as an antineoplastic in the form of the levo isomer - MELPHALAN, the racemic mixture - MERPHALAN, and the dextro isomer - MEDPHALAN; toxic to bone marrow, but little vesicant action; potential carcinogen.
Substances that reduce or suppress INFLAMMATION.
An anthracenedione-derived antineoplastic agent.
Antibodies obtained from a single clone of cells grown in mice or rats.
The mechanical property of material that determines its resistance to force. HARDNESS TESTS measure this property.
A method of studying a drug or procedure in which both the subjects and investigators are kept unaware of who is actually getting which specific treatment.
Elements of limited time intervals, contributing to particular results or situations.
An antineoplastic antimetabolite with immunosuppressant properties. It is an inhibitor of TETRAHYDROFOLATE DEHYDROGENASE and prevents the formation of tetrahydrofolate, necessary for synthesis of thymidylate, an essential component of DNA.
The extent to which the active ingredient of a drug dosage form becomes available at the site of drug action or in a biological medium believed to reflect accessibility to a site of action.
A complex of related glycopeptide antibiotics from Streptomyces verticillus consisting of bleomycin A2 and B2. It inhibits DNA metabolism and is used as an antineoplastic, especially for solid tumors.
Therapeutic act or process that initiates a response to a complete or partial remission level.
The relative equivalency in the efficacy of different modes of treatment of a disease, most often used to compare the efficacy of different pharmaceuticals to treat a given disease.
A form of phototherapy using color to influence health and to treat various physical or mental disorders. The color rays may be in the visible or invisible spectrum and can be administered through colored lights or applied mentally through suggestion.
Hard or soft soluble containers used for the oral administration of medicine.
Compounds that provide LUBRICATION between surfaces in order to reduce FRICTION.
Completed forms of the pharmaceutical preparation in which prescribed doses of medication are included. They are designed to resist action by gastric fluids, prevent vomiting and nausea, reduce or alleviate the undesirable taste and smells associated with oral administration, achieve a high concentration of drug at target site, or produce a delayed or long-acting drug effect.
Any of a group of malignant tumors of lymphoid tissue that differ from HODGKIN DISEASE, being more heterogeneous with respect to malignant cell lineage, clinical course, prognosis, and therapy. The only common feature among these tumors is the absence of giant REED-STERNBERG CELLS, a characteristic of Hodgkin's disease.
A nitrogen mustard alkylating agent used as antineoplastic for chronic lymphocytic leukemia, Hodgkin's disease, and others. Although it is less toxic than most other nitrogen mustards, it has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (Merck Index, 11th ed)
A cyclic undecapeptide from an extract of soil fungi. It is a powerful immunosupressant with a specific action on T-lymphocytes. It is used for the prophylaxis of graft rejection in organ and tissue transplantation. (From Martindale, The Extra Pharmacopoeia, 30th ed).
Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.
A malignant disease characterized by progressive enlargement of the lymph nodes, spleen, and general lymphoid tissue. In the classical variant, giant usually multinucleate Hodgkin's and REED-STERNBERG CELLS are present; in the nodular lymphocyte predominant variant, lymphocytic and histiocytic cells are seen.
A polysaccharide with glucose units linked as in CELLOBIOSE. It is the chief constituent of plant fibers, cotton being the purest natural form of the substance. As a raw material, it forms the basis for many derivatives used in chromatography, ion exchange materials, explosives manufacturing, and pharmaceutical preparations.
The chemical and physical integrity of a pharmaceutical product.
An antibiotic substance derived from Penicillium stoloniferum, and related species. It blocks de novo biosynthesis of purine nucleotides by inhibition of the enzyme inosine monophosphate dehydrogenase. Mycophenolic acid is important because of its selective effects on the immune system. It prevents the proliferation of T-cells, lymphocytes, and the formation of antibodies from B-cells. It also may inhibit recruitment of leukocytes to inflammatory sites. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p1301)
A polyvinyl polymer of variable molecular weight; used as suspending and dispersing agent and vehicle for pharmaceuticals; also used as blood volume expander.
... or prednisone tablets in a dosing regimen that mimics the physiological concentrations of cortisol. Alternatively, one-quarter ... In anticipation of stressful situations, such as staying in a boarding kennel, dogs require an increased dose of prednisone. ... such as prednisone. Several follow-up blood tests are required so the dose can be adjusted until the dog is receiving the ... When the person can take fluids and medications by mouth, the amount of glucocorticoids is decreased until a maintenance dose ...
Prednisone in tablet form, when dispensed in packages containing no more than 105 mg. Methylprednisone in tablet form in ... All unit dose forms of potassium supplements, including individually wrapped effervescent tablets, unit dose vials of liquid ... that are packaged in unit doses providing no more than 13 grains of acetaminophen per unit dose. Ibuprofen. Any product that is ... and powdered potassium in unit-dose packets containing no more than 50 milliequivalents of potassium per unit dose. Sodium ...
"Pharmacokinetics and Bioavailability Study of a Prednisolone Tablet as a Single Oral Dose in Bangladeshi Healthy Volunteers". ... Prednisolone is a synthetic pregnane corticosteroid closely related to its cognate prednisone, having identical structure save ... Prednisolone oral tablets (Millipred) Prednisolone sodium phosphate oral dissolving tablets (Orapred ODT) Prednisolone acetate ... Prednisolone in lower doses can be used in cases of primary adrenal insufficiency (Addison's disease). Corticosteroids inhibit ...
... 's potency is around 70-90% that of prednisone.[5] A 2017 review found its activity of 7.5 mg of deflazacort is ... The review noted that the drug has a high therapeutic index, being used at initial oral doses ranging from 6 to 90 mg, and ... The U.S. Food and Drug Administration approved Emflaza (deflazacort) tablets and oral suspension to treat patients age 5 years ... Preclinical data showed Deflazacort had acute toxicity with an oral lethal dose (LD50) greater than 5,200 mg/kg in a mouse. The ...
... may start to result in the suppression of the hypothalamic-pituitary-adrenal (HPA) axis if used at doses 7-10 mg or ... The pharmaceutical industry uses prednisone tablets for the calibration of dissolution testing equipment according to the ... "Prednisone Use During Pregnancy". Drugs.com. Retrieved 24 December 2018.. *^ "Product Information Panafcort (prednisone) ... Prednisone is a synthetic glucocorticoid used for its anti-inflammatory and immunosuppressive properties.[32][33] Prednisone is ...
The dose was increased until a persistent response was evident, toxicity was reached, or 175 mg twice a day was met. 8 patients ... The tablets are formulated as fostamatinib disodium hexahydrate, a disodium hexahydrate salt, and is a prodrug of the active ... 15 mg/day of prednisone or any other corticosteroid equivalent. The study investigates whether fostamatinib is a safe and ... Dose could be escalated to 150 mg orally twice daily after one month. The benefit of fostamatinib was assessed based on the ...
... may start to result in the suppression of the hypothalamic-pituitary-adrenal (HPA) axis if used at doses 7-10 mg or ... The pharmaceutical industry uses prednisone tablets for the calibration of dissolution testing equipment according to the ... Prednisone is a prodrug; it is metabolised in the liver by 11-β-HSD to prednisolone, the active drug. Prednisone has no ... After prolonged use, prednisone needs to be stopped gradually. Prednisone is a pro drug and must be converted to prednisolone ...
... or prednisone tablets in a dosing regimen that mimics the physiological concentrations of cortisol. Alternatively, one-quarter ... such as prednisone.[43] Several follow-up blood tests are required so that the dose can be adjusted until the dog is receiving ... dogs require an increased dose of prednisone.[43] Lifelong treatment is required, but the prognosis for dogs with ... When the person can take fluids and medications by mouth, the amount of glucocorticoids is decreased until a maintenance dose ...
Systemic steroids such as prednisone tablets and intramuscular triamcinolone acetonide or glucocorticoid (such as betamethasone ... Allergen immunotherapy (AIT, also termed desensitization) treatment involves administering doses of allergens to accustom the ... The allergen can be given as an injection under the skin or as a tablet under the tongue. Treatment typically lasts three to ... In 2013, a study compared the efficacy of mometasone furoate nasal spray to betamethasone oral tablets for the treatment of ...
... with a maximum daily dose of five tablets or 1375 mg. In the United Kingdom, 250 mg tablets of naproxen were approved for OTC ... or steroid medicines such as prednisone. NSAIDs such as naproxen may interfere with and reduce the efficacy of SSRI ... 250 mg tablet of naproxen 220 mg tablet of naproxen sodium. Imprint L490 (upside-down). Round, light blue tablet. Naproxen ... "Naprosyn- naproxen tablet EC-Naprosyn- naproxen tablet, delayed release Anaprox DS- naproxen sodium tablet". DailyMed. 1 July ...
Large single doses are generally well tolerated; a patient who took 7.5 g azathioprine (150 tablets) at once showed no relevant ... Azathioprine is sometimes used in systemic lupus erythematosus, requiring a maintenance dose of 15 mg or higher of prednisone ... Lower doses of azathioprine are used as a therapy in children with refractory or corticosteroid-dependent Crohn's disease, ... Low doses of allopurinol, though, have been shown to safely enhance the efficacy of azathioprine, especially in inflammatory ...
AG is provided most commonly in the form of 250 mg tablets. AG is used by bodybuilders, athletes, and other men to lower ... Cortisol is catabolic to protein in muscle and effective suppression of cortisol by AG at high doses can prevent muscle loss. ... prednisone, or an equivalent corticosteroid to prevent adrenal insufficiency. AG is a second- or third-line choice in the ...
... has been tested for use in sarcoidosis patients as an alternative or compliment to prednisone and other steroids ... "PENTOXIFYLLINE tablet, extended release [Apotex Corp.]". DailyMed. Apotex Corp. February 2013. Retrieved 3 February 2014. " ... "Trental, Pentoxil (pentoxifylline) dosing, indications, interactions, adverse effects, and more". Medscape Reference. WebMD. ... doses of pentoxifylline and distances participants could walk at the start of trials. Most included studies did not report on ...
Increasing the dose can overcome the effects of tolerance, but tolerance to the higher dose may occur and adverse effects may ... Clonazepam is available as tablets and orally disintegrating tablets (wafers) an oral solution (drops), and as a solution for ... Hrachovy RA, Frost JD, Kellaway P, Zion TE (October 1983). "Double-blind study of ACTH vs prednisone therapy in infantile ... Hollister LE (1975). "Dose-ranging studies of clonazepam in man". Psychopharmacol Commun. 1 (1): 89-92. PMID 1223993.. ...
A very high dose is often needed early in treatment, but, if too high a dose is used persistently, patients can develop ... Carbimazole is only available as a once daily tablet. Methimazole is available as an oral solution, a tablet, and compounded as ... Patients with mild or no ophthalmic symptoms can mitigate their risk with a concurrent six-week course of prednisone. The ... Depending on the dose of radioiodine chosen, and the disease under treatment (Graves' vs. toxic goiter, vs. hot nodule etc.), ...
"Prednisone and other corticosteroids: Balance the risks and benefits". Retrieved 4 March 2018. "Fluticasone Nasal Spray". AHFS ... Using the spray or inhaler at higher than recommended doses or with other corticosteroids can increase the risk for serious, ... If taken correctly, the nasal spray and oral inhaler formulation have fewer corticosteroid side effects than the tablet ... Fluticasone propionate is stated to exert a topical effect on the lungs without significant systemic effects at usual doses, ...
150 mg doses were commonly used to relieve the pain of arthritis, while 200 mg doses were commonly prescribed in cases of ... Veterinary dosage forms include 25 mg, 75 mg, and 100 mg tablets, and 50 mg per mL injectable form. Drugs.com International ... cortisone or prednisone. Carprofen must be used with caution within the supervision of a veterinarian in dogs with liver or ... A single dose has been shown to reduce prostaglandin E2 production and inflammatory exudate for up to 15 hours, although there ...
Carbimazole is only available as a once daily tablet. Methimazole is available as an oral solution, a tablet, and compounded as ... People not responding sufficiently to the first dose are sometimes given an additional radioiodine treatment, at a larger dose ... People with mild or no ophthalmic symptoms can mitigate their risk with a concurrent six-week course of prednisone. The ... A very high dose is often needed early in treatment, but, if too high a dose is used persistently, people can develop symptoms ...
... and prednisone had an estimated overall survival of 83% at 30 months, lenalidomide plus low-dose dexamethasone an 82% survival ... "Xpovio (selinexor) Tablets, for Oral Use. Full Prescribing Information" (PDF). Karyopharm Therapeutics Inc. 85 Wells Avenue, ... Overall the 5-year survival rate is around 54% in the United States.[93] With high-dose therapy followed by ASCT, the median ... The preferred treatment for those under the age of 65 is high-dose chemotherapy, commonly with bortezomib-based regimens, and ...
October 2007). "Melphalan and prednisone plus thalidomide versus melphalan and prednisone alone or reduced-intensity autologous ... It is taken as a tablet (by mouth) or by injection into a vein. Common side effects include nausea and bone marrow suppression ... In 2016, it was approved in the U.S. for: use as a high-dose conditioning treatment prior to hematopoietic progenitor (stem) ...
Klonopin 0.5 mg tablet Klonopin 1 mg tablet Klonopin 2 mg tablet Clonazepam orally disintegrating tablet, 0.25 mg "Clonazepam ... Increasing the dose can overcome the effects of tolerance, but tolerance to the higher dose may occur and adverse effects may ... Hrachovy RA, Frost JD, Kellaway P, Zion TE (October 1983). "Double-blind study of ACTH vs prednisone therapy in infantile ... Clonazepam is available as tablets and orally disintegrating tablets (wafers) an oral solution (drops), and as a solution for ...
... is available in the form of 250 mg and 500 mg film-coated oral tablets and 250 mg uncoated oral tablets. It ... "Zytiga (abiraterone) dosing, indications, interactions, adverse effects, and more". Medscape Reference. WebMD. Retrieved 24 ... Abiraterone acetate is used in combination with prednisone, a corticosteroid, as a treatment for mCRPC (previously called ... Abiraterone acetate is also available in the form of micronized 125 mg tablets used once per day at 500 mg in combination with ...
... prednisone or methylpredisolone tablets Rest ;Cortisol deficiency (primary and secondary) Hydrocortisone (Cortef) Prednisone ( ... Use of high-dose steroids for more than a week begins to produce suppression of the person's adrenal glands because the ...
... total daily doses of alternative glucocorticoids to dexamethasone 6 mg daily are methylprednisolone 32 mg and prednisone 40 mg ... "Dexamethasone Tablet BP 2.0 mg - Summary of Product Characteristics (SPC)". electronic Medicines Compendium. Merck Sharp & ... A single dose of dexamethasone or another steroid speeds improvement of a sore throat. Contraindications of dexamethasone ... Accept terms and conditions to open PDF, which doesn't work in archived version) "Dexamethasone tablet [ECR Pharmaceuticals]". ...
"ARAVA (leflunomide) tablet, film coated [sanofi-aventis U.S. LLC]". DailyMed. sanofi-aventis U.S. LLC. November 2012. Retrieved ... "Arava (leflunomide) dosing, indications, interactions, adverse effects, and more". Medscape Reference. WebMD. Retrieved 11 ... Clinical trial number NCT00004071 for "Mitoxantrone and Prednisone With or Without Leflunomide in Treating Patients With Stage ... Product: ARAVA (leflunomide tablets). Application Number: NDA 20905" (PDF). U.S. Food and Drug Administration. Center for Drug ...
... dose and duration have been implicated in PAE development. 20 mg/day of prednisone (16 mg/day of ... Methylprednisolone (Medrol) for oral administration is available in a tablet formulation in 2 mg, 4 mg, 8 mg, 16 mg or 32 mg ... It is either used at low doses for chronic illnesses or used concomitantly at high doses during acute flares. ... and human immune cells that were administered high doses of methylprednisolone has been shown to inhibit respiration in a dose- ...
... "dose pack" detailing a specific number of tablets to take at designated times over a several-day period. Pharmacists sometimes ... Prednisone. *Tixocortol *Tixocortol pivalate. *Methasones and related (16-substituted): Alclometasone. *Beclometasone * ... "Medrol (Methylprednisolone - Tablets by Pfizer)". Sfatul Medicului. Archived from the original on 5 April 2013. Retrieved 14 ... Also, live, attenuated vaccines can be bad for people taking immunosuppressive doses of methylprednisolone. The exception to ...
Bechstein WO, Suzuki Y, Kawamura T, Jaffee B, Allison A, Hullett DA, Sollinger HW (1992). "Low-dose combination therapy of DUP- ... "CellCept- mycophenolate mofetil tablet, film coated CellCept- mycophenolate mofetil capsule CellCept- mycophenolate mofetil ... dexamethasone or prednisone). Mycophenolate mofetil is the morpholino‌ ethyl ester of mycophenolic acid; the ester masks the ... "CellCept, Myfortic (mycophenolate) dosing, indications, interactions, adverse effects, and more". reference.medscape.com. ...
"Asacol 400mg MR Tablets - Summary of Product Characteristics (SmPC)". (emc). 14 April 2016. Retrieved 30 December 2019.. ... 5 hours after initial dose.. At steady state 7 hours. Identifiers. IUPAC name ... "Asacol HD- mesalamine tablet, delayed release". DailyMed. 15 April 2018. Retrieved 30 December 2019.. ...
Systemic steroids such as prednisone tablets and intramuscular triamcinolone acetonide or glucocorticoid (such as betamethasone ... Allergen immunotherapy (AIT, also termed desensitization) treatment involves administering doses of allergens to accustom the ... In 2013, a study compared the efficacy of mometasone furoate nasal spray to betamethasone oral tablets for the treatment of ... The allergen may be given as injections just under the skin or as a tablet under the tongue.[6] Treatment typically lasts three ...
"Xifaxan® (rifaximin) Tablets 550 mg for Hepatic Encephalopathy" (PDF). United States Food and Drug Administration ... In Russia as of 2016 a similar dose costs 231.25 RUB (approximately 4 USD).[3] ...
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"UCERIS (budesonide) extended release tablets label" (PDF). FDA.. *^ "FDA approves new treatment for moderately to severely ... van Deventer SJ, Wedel MK, Baker BF, Xia S, Chuang E, Miner PB (May 2006). "A phase II dose ranging, double-blind, placebo- ... Corticosteroids such as prednisone can also be used due to their immunosuppressive and short-term healing properties, but ... resuming low dose smoking may improve signs and symptoms of active ulcerative colitis.[91] Studies using a transdermal nicotine ...
As short-term overdosing of insulin causes short-term insulin resistance, it has been hypothesized that chronic high dosing ... Yasuda K, Hines E, Kitabchi AE (November 1982). "Hypercortisolism and insulin resistance: comparative effects of prednisone, ... so accompanying sub-lingual Vitamin B12 tablets are recommended. ... a fasting patient takes a 75 gram oral dose of glucose. Then ...
... is caused by either excessive cortisol-like medication, such as prednisone, or a tumor that either produces ... Abruptly stopping the medication can thus result in acute and potentially life-threatening adrenal insufficiency and the dose ... In March 2020, Isturisa (osilodrostat) oral tablets a 11-beta-hydroxylase enzyme inhibitor was approved by FDA for treating ... patients never recover sufficient levels of internal production and must continue taking glucocorticoids at physiological doses ...
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Higher doses of inhaled steroids may result in lower bone mineral density. Inflammation in the lungs can be estimated by the ... "Zyflo (Zileuton tablets)" (PDF). United States Food and Drug Administration. Cornerstone Therapeutics Inc. June 2012. p. 1. ... inhaled corticosteroids or prednisone, or a ≥20% decrease in peak flow following exposure to a trigger. Testing peak expiratory ... The spacer is a plastic cylinder that mixes the medication with air, making it easier to receive a full dose of the drug. A ...
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