DiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentHealth Care
PrednisoloneGlucocorticoidsAnti-Inflammatory AgentsAzathioprineMethylprednisoloneDrug Therapy, CombinationImmunosuppressive AgentsPulse Therapy, DrugBell PalsyAdministration, OralTablets, Enteric-CoatedNephrotic SyndromePrednisoneDouble-Blind MethodHydrocortisoneCyclosporineTreatment OutcomeEnemaIsonipecotic AcidsPolymyalgia RheumaticaAdrenal Cortex HormonesPregnenedionesSulfasalazineBetamethasoneDrug Administration ScheduleVincristine11-HydroxycorticosteroidsArthritis, Rheumatoid
Prednisolone
A glucocorticoid with the general properties of the corticosteroids. It is the drug of choice for all conditions in which routine systemic corticosteroid therapy is indicated, except adrenal deficiency states.
Glucocorticoids
A group of CORTICOSTEROIDS that affect carbohydrate metabolism (GLUCONEOGENESIS, liver glycogen deposition, elevation of BLOOD SUGAR), inhibit ADRENOCORTICOTROPIC HORMONE secretion, and possess pronounced anti-inflammatory activity. They also play a role in fat and protein metabolism, maintenance of arterial blood pressure, alteration of the connective tissue response to injury, reduction in the number of circulating lymphocytes, and functioning of the central nervous system.
Anti-Inflammatory Agents
Substances that reduce or suppress INFLAMMATION.
Azathioprine
An immunosuppressive agent used in combination with cyclophosphamide and hydroxychloroquine in the treatment of rheumatoid arthritis. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), this substance has been listed as a known carcinogen. (Merck Index, 11th ed)
Methylprednisolone
A PREDNISOLONE derivative with similar anti-inflammatory action.
Drug Therapy, Combination
Therapy with two or more separate preparations given for a combined effect.
Immunosuppressive Agents
Agents that suppress immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-CELLS or by inhibiting the activation of HELPER CELLS. While immunosuppression has been brought about in the past primarily to prevent rejection of transplanted organs, new applications involving mediation of the effects of INTERLEUKINS and other CYTOKINES are emerging.
Pulse Therapy, Drug
Administration of high doses of pharmaceuticals over short periods of time.
Bell Palsy
A syndrome characterized by the acute onset of unilateral FACIAL PARALYSIS which progresses over a 2-5 day period. Weakness of the orbicularis oculi muscle and resulting incomplete eye closure may be associated with corneal injury. Pain behind the ear often precedes the onset of paralysis. This condition may be associated with HERPESVIRUS 1, HUMAN infection of the facial nerve. (Adams et al., Principles of Neurology, 6th ed, p1376)
Administration, Oral
The giving of drugs, chemicals, or other substances by mouth.
Tablets, Enteric-Coated
Tablets coated with material that delays release of the medication until after they leave the stomach. (Dorland, 28th ed)
Nephrotic Syndrome
A condition characterized by severe PROTEINURIA, greater than 3.5 g/day in an average adult. The substantial loss of protein in the urine results in complications such as HYPOPROTEINEMIA; generalized EDEMA; HYPERTENSION; and HYPERLIPIDEMIAS. Diseases associated with nephrotic syndrome generally cause chronic kidney dysfunction.
Prednisone
A synthetic anti-inflammatory glucocorticoid derived from CORTISONE. It is biologically inert and converted to PREDNISOLONE in the liver.
Double-Blind Method
A method of studying a drug or procedure in which both the subjects and investigators are kept unaware of who is actually getting which specific treatment.
Hydrocortisone
The main glucocorticoid secreted by the ADRENAL CORTEX. Its synthetic counterpart is used, either as an injection or topically, in the treatment of inflammation, allergy, collagen diseases, asthma, adrenocortical deficiency, shock, and some neoplastic conditions.
Cyclosporine
A cyclic undecapeptide from an extract of soil fungi. It is a powerful immunosupressant with a specific action on T-lymphocytes. It is used for the prophylaxis of graft rejection in organ and tissue transplantation. (From Martindale, The Extra Pharmacopoeia, 30th ed).
Treatment Outcome
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
Enema
A solution or compound that is introduced into the RECTUM with the purpose of cleansing the COLON or for diagnostic procedures.
Isonipecotic Acids
Polymyalgia Rheumatica
A syndrome in the elderly characterized by proximal joint and muscle pain, high erythrocyte sedimentation rate, and a self-limiting course. Pain is usually accompanied by evidence of an inflammatory reaction. Women are affected twice as commonly as men and Caucasians more frequently than other groups. The condition is frequently associated with GIANT CELL ARTERITIS and some theories pose the possibility that the two diseases arise from a single etiology or even that they are the same entity.
Adrenal Cortex Hormones
Pregnenediones
Unsaturated pregnane derivatives containing two keto groups on side chains or ring structures.
Sulfasalazine
A drug that is used in the management of inflammatory bowel diseases. Its activity is generally considered to lie in its metabolic breakdown product, 5-aminosalicylic acid (see MESALAMINE) released in the colon. (From Martindale, The Extra Pharmacopoeia, 30th ed, p907)
Betamethasone
A glucocorticoid given orally, parenterally, by local injection, by inhalation, or applied topically in the management of various disorders in which corticosteroids are indicated. Its lack of mineralocorticoid properties makes betamethasone particularly suitable for treating cerebral edema and congenital adrenal hyperplasia. (From Martindale, The Extra Pharmacopoeia, 30th ed, p724)
Drug Administration Schedule
Time schedule for administration of a drug in order to achieve optimum effectiveness and convenience.
Vincristine
An antitumor alkaloid isolated from VINCA ROSEA. (Merck, 11th ed.)
11-Hydroxycorticosteroids
A group of corticosteroids bearing a hydroxy group at the 11-position.
Arthritis, Rheumatoid
A chronic systemic disease, primarily of the joints, marked by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. Etiology is unknown, but autoimmune mechanisms have been implicated.

Acute haemodynamic and proteinuric effects of prednisolone in patients with a nephrotic syndrome. (1/2898)

BACKGROUND: Administration of prednisolone causes an abrupt rise in proteinuria in patients with a nephrotic syndrome. METHODS: To clarify the mechanisms responsible for this increase in proteinuria we have performed a placebo controlled study in 26 patients with a nephrotic syndrome. Systemic and renal haemodynamics and urinary protein excretion were measured after prednisolone and after placebo. RESULTS: After i.v. administration of 125-150 mg prednisolone total proteinuria increased from 6.66+/-4.42 to 9.37+/-6.07 mg/min (P<0.001). By analysing the excretion of proteins with different charge and weight (albumin, transferrin, IgG, IgG4 and beta2-microglobulin) it became apparent that the increase of proteinuria was the result of a change in size selectivity rather than a change in glomerular charge selectivity or tubular protein reabsorption. Glomerular filtration rate rose from 83+/-34 ml to 95+/-43 ml/min (P<0.001) after 5 h, whereas effective renal plasma flow and endogenous creatinine clearance remained unchanged. As a result filtration fraction was increased, compatible with an increased glomerular pressure, which probably contributes to the size selectivity changes. Since corticosteroids affect both the renin-angiotensin system and renal prostaglandins, we have evaluated the effects of prednisolone on proteinuria after pretreatment with 3 months of the angiotensin-converting enzyme inhibitor lisinopril or after 2 weeks of the prostaglandin synthesis inhibitor indomethacin. Neither drug had any effect on prednisolone-induced increases of proteinuria. CONCLUSIONS: Prednisolone increases proteinuria by changing the size selective barrier of the glomerular capillary. Neither the renin-angiotensin axis nor prostaglandins seem to be involved in these effects of prednisolone on proteinuria.  (+info)

Primary biliary cirrhosis associated with membranous glomerulonephritis. (2/2898)

A 33-year-old woman was admitted to our department for evaluation of liver dysfunction and proteinuria. A liver biopsy specimen showed ductular proliferation and moderate portal fibrosis indicating stage II primary biliary cirrhosis. A renal biopsy specimen showed mild to moderate mesangial cell proliferation without crescent formation or interstitial nephritis. Immunofluorescent staining revealed deposition of immunoglobulin G (IgG), third component of complement (C3), and Clq on glomerular basement membranes. The findings indicated stage I membranous glomerulonephritis. Administration of ursodesoxycholic acid together with prednisolone, azathioprine, and dipyridamole decreased proteinuria and improved cholestatic liver dysfunction.  (+info)

Effective control of Epstein-Barr virus-related hemophagocytic lymphohistiocytosis with immunochemotherapy. Histiocyte Society. (3/2898)

The familial form of hemophagocytic lymphohistiocytosis (HLH) is a lethal disorder. Although the prognosis for Epstein-Barr virus-associated HLH (EBV-HLH) remains uncertain, numerous reports indicate that it can also be fatal in a substantial proportion of cases. We therefore assessed the potential of immunochemotherapy with a core combination of steroids and etoposide to control EBV-HLH in 17 infants and children who met stringent diagnostic criteria for this reactive disorder of the mononuclear phagocyte system. Treatment of life-threatening emergencies was left to the discretion of participating investigators and typically included either intravenous Ig or cyclosporin A (CSA). Five patients (29%) entered complete remission during the induction phase (1 to 2 months), whereas 10 others (57%) required additional treatment to achieve this status. In 2 cases, immunochemotherapy was ineffective, prompting allogeneic bone marrow transplantation. Severe but reversible myelosuppression was a common finding; adverse late sequelae were limited to epileptic activity in one child and chronic EBV infection in 2 others. Fourteen of the 17 patients treated with immunochemotherapy have maintained their complete responses for 4+ to 39+ months (median, 15+ months), suggesting a low probability of disease recurrence. These results provide a new perspective on EBV-HLH, showing effective control (and perhaps cure) of the majority of EBV-HLH cases without bone marrow transplantation, using steroids and etoposide, with or without immunomodulatory agents.  (+info)

Th1 and Th2 cytokine mRNA profiles in childhood nephrotic syndrome: evidence for increased IL-13 mRNA expression in relapse. (4/2898)

Idiopathic nephrotic syndrome of childhood is thought to be associated with T lymphocyte dysfunction often triggered by viral infections, with the production of circulating factor(s) resulting in proteinuria. In view of the conflicting evidence of T cell activation and Th1 or Th2 pattern of cytokine synthesis in this disease, this study examined the mRNA expression of interleukin-2 (IL-2), interferon-gamma, IL-4, and IL-13 from CD4+ and CD8+ T cells in steroid-responsive nephrotic patients in relapse and remission. Fifty-five children with steroid-responsive nephrotic syndrome were included in this study, together with 34 normal controls and 24 patient controls with viral infections. RNA was isolated from purified CD4+ or CD8+ cells from peripheral blood and subjected to reverse transcription-PCR. Cytokine mRNA expression was measured semiquantitatively, and a cytokine index was derived from densitometric readings, with cyclophilin as the housekeeping gene. Both cross-sectional and paired data showed an increased CD4+ and CD8+ IL-13 mRNA expression in patients with nephrotic relapse as compared to remission, normal, and patient controls (P < 0.008). This was also associated with increased cytoplasmic IL-13 expression in phorbol myristate acetate/ionomycin-activated CD3+ cells (6.66+/-3.39%) from patients with nephrotic relapse compared to remission (2.59+/-1.35%) (P < 0.0001). However, there was no significant difference in CD4+ or CD8+ IL-2, interferon-gamma and IL-4 mRNA expression. IL-13 is an important T cell cytokine with anti-inflammatory and immunomodulatory functions on B cells and monocytes. It is conceivable that IL-13 may act on monocytes to produce vascular permeability factor(s) involved in the pathogenesis of proteinuria in patients with relapse nephrotic syndrome.  (+info)

A case of eosinophilic myocarditis complicated by Kimura's disease (eosinophilic hyperplastic lymphogranuloma) and erythroderma. (5/2898)

This report describes a patient with eosinophilic myocarditis complicated by Kimura's disease (eosinophilic hyperplastic lymphogranuloma) and erythroderma. A 50-year-old man presented with a complaint of precordial pain. However, the only abnormal finding on examinatioin was eosinophilia (1617 eosinophils/microl). Three years later, the patient developed chronic eczema, and was diagnosed with erythroderma posteczematosa. One year later, a tumor was detected in the right auricule, and a diagnosis of Kimura's disease was made, based on the biopsy findings. The patient developed progressive dyspnea 6 months later and was found to have cardiomegaly and a depressed left ventricular ejection fraction (17%). A diagnosis of eosinophilic myocarditis was made based on the results of a right ventricular endomyocardial biopsy. The eosinophilic myocarditis and erythrodrema were treated with steroids with improvement of both the eosinophilia and left ventricular function.  (+info)

Serum lipoprotein(a) and apolipoprotein(a) phenotypes in patients with rheumatoid arthritis. (6/2898)

OBJECTIVE: To determine serum lipoprotein(a) (Lp[a]) concentrations and to analyze the apolipoprotein(a) (Apo[a]) phenotype in patients with rheumatoid arthritis (RA). METHODS: The subjects included 131 patients with RA and 200 healthy control subjects. Serum Lp(a) concentrations were measured by enzyme-linked immunosorbent assay, and the Apo(a) phenotype was determined by immunoblotting. HLA-DR typing was also done. RESULTS: The mean serum Lp(a) level was significantly higher (P < 0.001) in the RA patients (27.5 mg/dl) than in the controls (15.0 mg/dl). The S3 allele was found in 70.0% of the patients versus 39.5% of the controls (P < 0.001). There was no significant difference in HLA-DR4 positivity between patients with and without the S3 phenotype. CONCLUSION: The serum Lp(a) level was increased in patients with RA, possibly partly because of S3 phenotype predominance.  (+info)

Effective immunosuppressive therapy in a patient with primary pulmonary hypertension. (7/2898)

The case history is described of a young woman who presented with primary pulmonary hypertension and non-specific inflammatory signs. The patient received prolonged immunosuppressive treatment with low dose methotrexate and prednisone without any vasodilator agent. After one year the pulmonary artery pressure fell from a mean value of 47 mm Hg to 30 mm Hg and there was a corresponding clinical response. This case suggests that, in patients with pulmonary hypertension of unknown origin, immunopathogenetic factors should be sought in order to consider the utility of immunosuppressive therapy.  (+info)

A pharmacoeconomic analysis of rimexolone for the treatment of ophthalmic inflammatory conditions. (8/2898)

Topical steroids are the standard first-line therapy for treating ophthalmic inflammatory conditions. However, potent ophthalmic steroids can lead to an elevation of intraocular pressure (IOP), which can result in greater medical resource utilization and increased costs. We have developed a decision analysis model from a societal perspective to evaluate the costs and consequences of the treatment of ophthalmic inflammatory conditions with two potent topical steroids: prednisolone and rimexolone. Data for the model are based on information from clinical trials, national data-bases, published literature, and responses by ophthalmologists to a questionnaire on treatment patterns for elevated IOP. Three steroid-responsive conditions are examined separately with the model: uveitis; postoperative inflammation following cataract surgery; and other ophthalmic inflammatory conditions (blepharitis, episcleritis, postoperative refractive surgery, and corneal transplant). The model evaluates patients with acute conditions versus those with chronic conditions and those with mild to moderate elevation of IOP versus those with severe elevation of IOP. Although the unit cost of rimexolone is higher than that of prednisolone, use of rimexolone leads to cost savings because the incidence of elevated IOP is decreased. If rimexolone is used instead of prednisolone for the treatment of ophthalmic inflammatory conditions, the estimated cost saved (at 1995 AWP prices) is approximately $10 million across the entire US population. The savings across the health maintenance organization population on an annualized basis is approximately $3.9 million. Even if rimexolone were priced higher than current market charges (at 130% to 150% of the AWP of prednisolone), cost savings ranging from the $2.9 million to $720,000 would accrue with use of rimexolone compared with prednisolone. However if, rimexolone were priced at 160% of the AWP of prednisolone, its use would incur an additional cost of $300,000. The primary medical resource utilized in treating elevated IOP in ophthalmic inflammatory conditions is physician visits. Medications are responsible for only one-fifth to one-third of the total cost of treating elevated IOP. This analysis indicates that rimexolone is associated with decreased medical resource utilization and cost savings to the entire healthcare system.  (+info)

Bell's palsy is a condition that affects the nerve that controls the muscles on one side of your face. It can cause weakness or paralysis of the facial muscles, leading to drooping or weakness on one side of the face.

The term "Bell's palsy" was coined by Sir Charles Bell in 1829, and it is named after him. The condition is caused by damage to the facial nerve, which can be due to a variety of factors such as viral infections, autoimmune disorders, trauma, or tumors.

Bell's palsy can cause a range of symptoms including:

* Weakness or paralysis of the facial muscles on one side of the face
* Drooping or weakness of the eyelid or corner of the mouth
* Difficulty closing the eye or smiling
* Dryness or excessive tearing of the eye
* Increased sensitivity to sound or touch on the affected side
* Pain or discomfort in the face, jaw, or ear

Bell's palsy can be diagnosed by a neurologist based on symptoms and physical examination. Imaging tests such as MRI or CT scans may be ordered to rule out other conditions that can cause similar symptoms.

There is no cure for Bell's palsy, but various treatments can help manage the symptoms. These may include:

* Medications to reduce inflammation and pain
* Physical therapy to improve facial function and appearance
* Surgery to repair or remove damaged nerve tissue
* Corticosteroid injections to reduce swelling and inflammation

The prognosis for Bell's palsy is generally good, with most people experiencing a full recovery within a few weeks to months. However, some people may experience long-term symptoms or complications such as permanent nerve damage or eye dryness.

Nephrotic syndrome is a condition characterized by the loss of large amounts of protein in the urine, often due to damage to the glomeruli, the tiny blood vessels in the kidneys that filter waste and excess fluids from the blood. The condition can be caused by a variety of factors, including diabetes, lupus, and certain inherited disorders. Symptoms may include foamy urine, frequent urination, and swelling in the legs and feet. Treatment typically involves addressing the underlying cause of the condition and managing symptoms with medication and lifestyle changes.

Polymyalgia rheumatica (PMR) is a chronic inflammatory disorder that affects the muscles and joints, causing widespread pain and stiffness. It typically affects people over the age of 50, and is more common in women than men.

The exact cause of PMR is not known, but it is believed to be related to an abnormal immune response. The condition often occurs in conjunction with another inflammatory disorder called giant cell arteritis (GCA), which affects the blood vessels.

Symptoms of PMR include:

* Pain and stiffness in the shoulders, hips, and other joints
* Fatigue
* Fever
* Loss of appetite
* Sleep disturbances
* Weight loss

The diagnosis of PMR is based on a combination of symptoms, physical examination findings, and laboratory test results. Laboratory tests may include blood tests to check for inflammatory markers, such as erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP).

Treatment for PMR typically involves a combination of medications, including:

* Corticosteroids to reduce inflammation
* Pain relievers, such as nonsteroidal anti-inflammatory drugs (NSAIDs) or narcotics
* Anti-inflammatory medications, such as disease-modifying anti-rheumatic drugs (DMARDs) or biologic response modifiers

In addition to medication, physical therapy and exercise may be helpful in managing the symptoms of PMR. In some cases, surgery may be necessary to repair joint damage.

The prognosis for PMR is generally good, with most people experiencing significant improvement within a few months of starting treatment. However, the condition can be challenging to diagnose and treat, and it is important to work closely with a healthcare provider to find the most effective treatment plan.

Rheumatoid Arthritis (RA) is an autoimmune and inflammatory disease that affects the joints and can also damage other body systems. It occurs when the immune system mistakenly attacks healthy tissue, leading to pain, stiffness, and swelling in the joints.

There are several symptoms of RA, including:

1. Joint pain and stiffness, especially in the hands and feet
2. Swollen and warm joints
3. Redness and tenderness in the affected areas
4. Fatigue, fever, and loss of appetite
5. Loss of range of motion in the affected joints
6. Firm bumps of tissue under the skin (rheumatoid nodules)

RA can be diagnosed through a combination of physical examination, medical history, blood tests, and imaging studies such as X-rays or ultrasound. Treatment typically involves a combination of medications, including nonsteroidal anti-inflammatory drugs (NSAIDs), disease-modifying anti-rheumatic drugs (DMARDs), and biologic agents. Lifestyle modifications such as exercise and physical therapy can also be helpful in managing symptoms and improving quality of life.

There is no cure for RA, but early diagnosis and aggressive treatment can help to slow the progression of the disease and reduce symptoms. With proper management, many people with RA are able to lead active and fulfilling lives.

PrednisolonePrednisolone
... acetate oral suspension (Flo-Pred) Prednisolone oral tablets (Millipred) Prednisolone sodium phosphate oral ... Prednisolone can also be used as an immunosuppressive drug for organ transplants. Prednisolone in lower doses can be used in ... Prednisolone is found in breast milk of mothers taking prednisolone. As a glucocorticoid, the lipophilic structure of ... "Pred Forte- prednisolone acetate suspension/ drops". DailyMed. 19 July 2019. Retrieved 9 March 2020. "Pred Mild- prednisolone ...
https://en.wikipedia.org/wiki/Prednisolone
Topical prednisoloneTopical prednisolone
Prednisolone is 70-90% plasma protein bound, it binds to proteins such as albumin. Both prednisolone phosphate and prednisolone ... Prednisolone acetate eye drops are not to be used in other animals such as birds. Prednisolone acetate eye drops are also ... In addition, topical prednisolone can also be administered as ear drops. Prednisolone eye drops should not be shared between ... Topical prednisolone are normally formulated as sodium phosphate and acetates. Prednisolone eye drops are used in conjunctiva ...
https://en.wikipedia.org/wiki/Topical_prednisolone
Prednisolone acetatePrednisolone acetate
It is the 21-acetate ester of prednisolone. Prednisolone acetate is acutely toxic with an LD50 of >240 mg/kg for a rat and 3500 ... prednisolone sodium phosphate: a 20-year review". The CLAO Journal. 17 (4): 282-4. PMID 1764775. "Prednisolone 21-acetate P8650 ... "Prednisolone 21-acetate". pubchem.ncbi.nlm.nih.gov. Retrieved 2019-12-19. Sousa FJ (October 1991). "The bioavailability and ... Prednisolone acetate is a synthetic glucocorticoid corticosteroid and a corticosteroid ester. ...
https://en.wikipedia.org/wiki/Prednisolone_acetate
Δ7-PrednisoloneΔ7-Prednisolone
... , or 7-dehydroprednisolone, is a synthetic glucocorticoid corticosteroid which was never marketed. Bell PA, ...
https://en.wikipedia.org/wiki/Δ7-Prednisolone
Prednisolone sodium phosphatePrednisolone sodium phosphate
... is a synthetic glucocorticoid corticosteroid and a corticosteroid ester. "Prednisolone sodium ...
https://en.wikipedia.org/wiki/Prednisolone_sodium_phosphate
Epstein syndromeEpstein syndrome
"Prednisolone & Prednisone". "Cochlear Implants". 2015-08-18. Richards (1991). "Epstein syndrome: oral lesions ina patient with ... Intravenous immunoglobin treatments can be used to support the patient's immune system as well as medication with Prednisolone ...
https://en.wikipedia.org/wiki/Epstein_syndrome
List of hormonal cytostatic antineoplastic agentsList of hormonal cytostatic antineoplastic agents
... chlorambucil prednisolone ester; prednisolone 21-(4-(4-(bis(2-chloroethyl)amino)phenyl)butanoate)) Alestramustine (estradiol 3 ...
https://en.wikipedia.org/wiki/List_of_hormonal_cytostatic_antineoplastic_agents
SanofiSanofi
Pediapred (Prednisolone), for multiple sclerosis. Rilutek (Riluzole), for ALS. Sabril (Vigabatrin), for epilepsy, marketed by ...
https://en.wikipedia.org/wiki/Sanofi
Alcoholic hepatitisAlcoholic hepatitis
Prednisolone gave a small reduction in mortality at 28 days but this did not reach significance, and there were no improvements ... "Prednisolone or pentoxifylline for alcoholic hepatitis". N. Engl. J. Med. 372 (17): 1619-28. doi:10.1056/NEJMoa1412278. PMID ... 32 or hepatic encephalopathy should be considered for treatment with prednisolone 40 mg daily for four weeks followed by a ... A large prospective study of over 1000 patients investigated whether prednisolone and pentoxifylline produced benefits when ...
https://en.wikipedia.org/wiki/Alcoholic_hepatitis
Kathie L. OlsenKathie L. Olsen
Whalen, R. E.; Olsen, K. L. (1978). "Prednisolone modifies estrogen-induced sexual differentiation". Behavioral Biology. 24 (4 ...
https://en.wikipedia.org/wiki/Kathie_L._Olsen
Tietze syndromeTietze syndrome
McSweeny, AJ (September 1958). "Treatment of Tietze Disease with Prednisolone". Archives of Internal Medicine. 102 (3): 459-461 ...
https://en.wikipedia.org/wiki/Tietze_syndrome
STAMPEDE (clinical trial)STAMPEDE (clinical trial)
SOC plus abiraterone acetate and prednisolone. SOC plus RT. SOC plus abiraterone and enzalutamide and prednisolone. SOC plus ... Standard care plus docetaxel and prednisolone. SOC plus celecoxib. SOC plus zoledronic acid and docetaxel. SOC plus zoledronic ...
https://en.wikipedia.org/wiki/STAMPEDE_(clinical_trial)
PrednisonePrednisone
... is a prodrug and must be converted to prednisolone by the liver before it becomes active. Prednisolone then binds to ... Prednisone and prednisolone were introduced in 1955 by Schering and Upjohn, under the brand names Meticorten and Delta-Cortef, ... Prednisone is a prodrug; it is metabolised in the liver by 11-β-HSD to prednisolone, the active drug. Prednisone has no ... The first isolation and structure identifications of prednisone and prednisolone were done in 1950 by Arthur Nobile. The first ...
https://en.wikipedia.org/wiki/Prednisone
Breast hypertrophyBreast hypertrophy
19-. ISBN 978-1-4377-0604-8. Jabaiti, Samir; Fayyad, Luma; Isleem, Ula (2019-01-01). "Prednisolone-induced virginal mammary ... and prednisolone. Medical treatment has not proven consistently effective. Medical regimens have included tamoxifen, ...
https://en.wikipedia.org/wiki/Breast_hypertrophy
SulfacetamideSulfacetamide
It is available in fixed-dose combinations with prednisolone. Sulfacetamide is a sulfonamide antibiotic. Sulfonamides are ... 2015). Sulfacetamide Sodium 10% and Prednisolone Sodium Phosphate 0.25% Ophthalmic Solution. Naik PN (2008). "Mechanistic study ... "Blephamide- sulfacetamide sodium and prednisolone acetate suspension/ drops". DailyMed. 10 November 2016. Retrieved 10 June ... "Blephamide- sulfacetamide sodium and prednisolone acetate ointment". DailyMed. 29 June 2018. Retrieved 10 June 2020. " ...
https://en.wikipedia.org/wiki/Sulfacetamide
Cerebral vasculitisCerebral vasculitis
Prednisolone) Cyclophosphamide Azathioprine Mycophenolate mofetil "Cerebral Vasculitis". Prime Health Channel. 19 December 2012 ...
https://en.wikipedia.org/wiki/Cerebral_vasculitis
CorticosteroidCorticosteroid
Such as prednisone, prednisolone, methylprednisolone, or dexamethasone. Available in injectables for intravenous and parenteral ... Swinburn CR, Wakefield JM, Newman SP, Jones PW (December 1988). "Evidence of prednisolone induced mood change ('steroid ... Hydrocortisone, hydrocortisone acetate, cortisone acetate, tixocortol pivalate, prednisolone, methylprednisolone, and ...
https://en.wikipedia.org/wiki/Corticosteroid
Diffuse neonatal hemangiomatosisDiffuse neonatal hemangiomatosis
Initially, prednisolone was given as a first line treatment at 4 mg/kg/day for four weeks from 27 to 55 postnatal days. This ... Corticosteroids that are often used include Prednisone or Prednisolone, and the average dosing is 2-3 mg/kg given daily in the ... Zarem HA, Edgerton MT (January 1967). "Induced resolution of cavernous hemangiomas following prednisolone therapy". Plastic and ...
https://en.wikipedia.org/wiki/Diffuse_neonatal_hemangiomatosis
Legg-Calvé-Perthes diseaseLegg-Calvé-Perthes disease
Prednisolone tablets may also be helpful. Legg-Calve-Perthes Disease Imaging at eMedicine Yochum, Rowe (1987). Essentials of ...
https://en.wikipedia.org/wiki/Legg–Calvé–Perthes_disease
Hopkins syndromeHopkins syndrome
Nakano, Y; Kohira, R; Yamazaki, H; Fujita, N; Fuchigami, T; Okubo, O; Harada, K (2001). "Hopkins syndrome: oral prednisolone ...
https://en.wikipedia.org/wiki/Hopkins_syndrome
Fish scaleFish scale
"Prednisolone induces osteoporosis-like phenotype in regenerating zebrafish scales". Osteoporosis International. 25 (2): 567-578 ...
https://en.wikipedia.org/wiki/Fish_scale
Lotto-SoudalLotto-Soudal
"Van der Sande cleared after positive test for prednisolone". Cyclingnews. Future plc. Retrieved 29 April 2019. "Lotto-Soudal". ... "Van der Sande cleared after positive test for prednisolone". Cyclingnews. Future plc. Retrieved 29 April 2019. "Positive doping ... the wrong nasal spray brand in the paperwork at the 2018 Six Days of Ghent where he returned a positive test for prednisolone, ...
https://en.wikipedia.org/wiki/Lotto–Soudal
ZebrafishZebrafish
de Vrieze E, van Kessel MA, Peters HM, Spanings FA, Flik G, Metz JR (February 2014). "Prednisolone induces osteoporosis-like ...
https://en.wikipedia.org/wiki/Zebrafish
Tosh Van der SandeTosh Van der Sande
"Van der Sande cleared after positive test for prednisolone". Cyclingnews. Future plc. Retrieved 29 April 2019. "Positive doping ... the wrong nasal spray brand in the paperwork at the 2018 Six Days of Ghent where he returned a positive test for prednisolone, ...
https://en.wikipedia.org/wiki/Tosh_Van_der_Sande
MethylprednisoloneMethylprednisolone
... acetate suspension (Depo-Medrol) is a 6-methyl derivative of prednisolone that melts at 215 degrees Celsius ... Szefler SJ, Ebling WF, Georgitis JW, Jusko WJ (1986). "Methylprednisolone versus prednisolone pharmacokinetics in relation to ... Chemically, methylprednisolone is a synthetic pregnane steroid hormone derived from hydrocortisone and prednisolone. It belongs ... and prednisolone (11β,17α,21-trihydroxypregn-1,4-diene-3,20-dione). A variety of methylprednisolone esters with differing ...
https://en.wikipedia.org/wiki/Methylprednisolone
Glycated hemoglobinGlycated hemoglobin
Administration of prednisolone will allow the HbA1 to be detected. The alternative fructosamine test may be used in these ...
https://en.wikipedia.org/wiki/Glycated_hemoglobin
GeotrichosisGeotrichosis
The associated asthma can be treated with desensitization and prednisolone. Amphotericin B, clotrimazole and S-fluorocytosine ...
https://en.wikipedia.org/wiki/Geotrichosis
List of doping cases in cyclingList of doping cases in cycling
On 3 September, Benito Ros Charral tested positive for Prednisolone and was eventually stripped of all results from the date of ... Wilmer Bravo of Venezuela tested positive for Prednisolone and Prednisone on 9 January 2006. The UCI summary of 'Decisions on ... Cénéric Racault of France tested positive for Prednisolone and Prednisone. The UCI summary of 'Decisions on Anti-Doping Rule ...
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Dose of prednisolone3
  • Peak milk prednisolone levels occur about 1 hour after an oral dose of prednisolone and dropped with a half-life similar to the serum half-life. (nih.gov)
  • Your doctor may change your dose of prednisolone during your treatment to be sure that you are always taking the lowest dose that works for you. (medlineplus.gov)
  • Finally, for the third patient, the dose of prednisolone was tapered from 10 mg per day to 3 mg per day over 28 weeks after the initiation of satralizumab. (rarediseaseadvisor.com)
Ophthalmic suspension15
  • PRED MILD ® (prednisolone acetate ophthalmic suspension, USP) 0.12% is a topical anti-inflammatory agent for ophthalmic use. (druglib.com)
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  • Prednisolone Acetate Ophthalmic Suspension USP, 1% is an adrenocortical steroid product prepared as a sterile ophthalmic suspension. (nih.gov)
  • Prednisolone Acetate Ophthalmic Suspension USP, 1% is contraindicated in most viral diseases of the cornea and conjunctiva including epithelial herpes simplex keratitis (dendritic keratitis), vaccinia, and varicella, and also in mycobacterial infection of the eye and fungal diseases of ocular structures. (nih.gov)
  • Prednisolone Acetate Ophthalmic Suspension USP, 1% is also contraindicated in individuals with known or suspected hypersensitivity to any of the ingredients of this preparation and to other corticosteroids. (nih.gov)
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  • Results We included six RCTs with 883 patients: 441 received difluprednate and 442 received prednisolone acetate. (bmj.com)
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  • The respective infant weight-adjusted dosages were 0.58% and 0.35% of the maternal dose for prednisone and 0.18% and 0.09% for prednisolone. (nih.gov)
  • 4 mcg/L) after 12 hours for prednisone and 6 hours for prednisolone. (nih.gov)
  • tell your doctor and pharmacist if you are allergic to prednisolone, other corticosteroids such as prednisone (Rayos), any other medications, or any of the ingredients in prednisolone products. (medlineplus.gov)
  • Prednisone, dexamethasone, and prednisolone are examples of this type of medicine. (nih.gov)
  • It is the preferred anti-inflammatory drug for reducing airway edema in this setting, though other glucocorticoids have been used, including prednisone and prednisolone. (medscape.com)
Sodium2
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  • Used in combination with sodium valproate and prednisolone. (medscape.com)
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  • Patients with a clinical diagnosis of alcoholic hepatitis and severe disease were randomly assigned to one of four groups: a group that received a pentoxifylline-matched placebo and a prednisolone-matched placebo, a group that received prednisolone and a pentoxifylline-matched placebo, a group that received pentoxifylline and a prednisolone-matched placebo, or a group that received both prednisolone and pentoxifylline. (nih.gov)
  • Mortality at 28 days was 17% (45 of 269 patients) in the placebo-placebo group, 14% (38 of 266 patients) in the prednisolone-placebo group, 19% (50 of 258 patients) in the pentoxifylline-placebo group, and 13% (35 of 260 patients) in the prednisolone-pentoxifylline group. (nih.gov)
  • This study randomized 270 patients to receive either prednisolone and pentoxifylline or prednisolone and placebo for 28 days. (the-hospitalist.org)
  • In a previous clinical trial, satralizumab treatment was also shown to reduce the risk of relapse compared to placebo when prednisolone was tapered. (rarediseaseadvisor.com)
  • Oral prednisolone (0.25 mg/kg/ dose ) or placebo (11) was administered twice daily for 6 consecutive days. (bvsalud.org)
  • Two days after treatment initiation with prednisolone or placebo, 5 mg imiquimod (IMQ) once daily for two following days was applied under occlusion on the tape-stripped skin of the back for 48 h in healthy volunteers . (bvsalud.org)
  • Notably, TNF, IL-6 , IL-8 , and Mx-A responses in blister exudate were also reduced by prednisolone compared to placebo. (bvsalud.org)
Acetate plus1
  • As stated by the investigators, "Abiraterone acetate plus prednisolone or enzalutamide added at the start of [ADT] improves outcomes for patients with metastatic prostate cancer. (ascopost.com)
Inflammation5
  • Prednisolone improves liver function and reduces inflammation in patients with alcoholic hepatitis. (the-hospitalist.org)
  • Conclusion With low-to-moderate certainty, difluprednate and prednisolone acetate are safe agents for controlling the inflammation after cataract surgery. (bmj.com)
  • Prednisolone decreases inflammation by suppressing migration of PMNs and reducing capillary permeability. (medscape.com)
  • Oral prednisolone suppresses skin inflammation in a healthy volunteer imiquimod challenge model. (bvsalud.org)
  • Oral prednisolone suppresses IMQ-induced skin inflammation , which underlines the value of this cutaneous challenge model in clinical pharmacology studies of novel anti-inflammatory compounds. (bvsalud.org)
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Pentoxifylline5
  • Prednisolone and pentoxifylline are both recommended for the treatment of severe alcoholic hepatitis, but uncertainty about their benefit persists. (nih.gov)
  • We conducted a multicenter, double-blind, randomized trial with a 2-by-2 factorial design to evaluate the effect of treatment with prednisolone or pentoxifylline. (nih.gov)
  • Does the addition of pentoxifylline to prednisolone improve six-month mortality compared to prednisolone alone in patients with severe alcoholic hepatitis? (the-hospitalist.org)
  • Adding pentoxifylline to prednisolone does not improve six-month survival in severe alcoholic hepatitis compared to prednisolone alone. (the-hospitalist.org)
  • Prednisolone with vs without pentoxifylline and survival of patients with severe alcoholic hepatitis: a randomized clinical trial. (the-hospitalist.org)
Corticosteroids1
  • Prednisolone is in a class of medications called corticosteroids. (medlineplus.gov)
Suspension1
  • Prednisolone comes as a tablet, an orally disintegrating tablet (tablet that dissolves quickly in the mouth), a solution (liquid), and as a suspension (liquid) to take by mouth with food. (medlineplus.gov)
Doses4
  • After oral prednisolone, levels of 23 to 40 mcg/L occurred with doses of 10-20 mg in 3 women, while peak levels of 106 and 137 mcg/L occurred after doses of 30 and 45 mg, respectively and a peak prednisolone level of 317 mcg/L occurred after a dose of 80 mg. (nih.gov)
  • The ratio of the peak milk to peak plasma prednisolone levels were about 0.1 with doses of 20 mg or less while it was 0.2 with doses of 30 mg or more. (nih.gov)
  • Call your doctor if you experience these or other unusual symptoms while you are taking decreasing doses of prednisolone or after you stop taking the medication. (medlineplus.gov)
  • Monotherapy with prednisolone can prevent relapses in NMOSD but only at doses of 10 mg or more per day. (rarediseaseadvisor.com)
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Anti-inflammatory3
  • Their synthetic analogs such as prednisolone are primarily used for their potent anti-inflammatory effects in disorders of many organ systems. (nih.gov)
  • Prednisolone acetate is a glucocorticoid that, on the basis of weight, has 3 to 5 times the anti-inflammatory potency of hydrocortisone. (druglib.com)
  • The aim of this study was to profile the cellular, biochemical, and clinical effects of the marketed anti-inflammatory compound prednisolone in an IMQ model. (bvsalud.org)
Abiraterone1
  • In an analysis of the final results of two STAMPEDE platform phase III trials reported in The Lancet Oncology , Gerhardt Attard, PhD , and colleagues found that the addition of enzalutamide to abiraterone plus prednisolone did not appear to improve survival outcomes and was associated with worse toxicity among patients with metastatic prostate cancer initiating androgen-deprivation therapy (ADT). (ascopost.com)
Drugs2
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Oral3
  • Prednisolone Oral Solution contains prednisolone which is a glucocorticoid. (nih.gov)
  • Prednisolone Oral Solution contains 15 mg of prednisolone in each 5 mL. (nih.gov)
  • In addition to the above indications Prednisolone Oral Solution is indicated for systemic dermatomyositis (polymyositis). (nih.gov)
Farmacie2
Dexamethasone2
  • Many practitioners administer liquid prednisolone to patients with croup in lieu of dexamethasone. (medscape.com)
  • Prednisolone has not been proved superior to dexamethasone. (medscape.com)
Treatment13
  • The authors concluded that there is no risk for the infant from the usual short-term high-dose maternal prednisolone treatment, even when breastfed right after the injection. (nih.gov)
  • Finpecia is indicated for the treatment of male pattern hair loss on the vertex and the anterior prednisolone liquid uk . (apsia.org)
  • Prednisolone (PSL) added to intravenous immunoglobulin treatment for acute KD may reduce such abnormalities. (frontiersin.org)
  • Notably, combined treatment with prednisolone (PSL) is more effective in preventing CAAs than IVIG alone in non-responders, thereby reducing the need for additional rescue treatments ( 4 ). (frontiersin.org)
  • The aim of the trial was to see if the combination of custirsen, cabazitaxel and prednisolone is a useful treatment for men in this situation. (cancerresearchuk.org)
  • The Committee for Medicinal Products for Human Use (CHMP) of the European Medicines Agency (EMA) has recommended marketing authorisation for niraparib and AA, in the form of a DAT, given with P or prednisolone, for the treatment of adult patients with metastatic castration-resistant prostate cancer (mCRPC) and BRCA1/2 mutations (germline and/or somatic) in whom chemotherapy is not clinically indicated. (ecancer.org)
  • Cialis is indicated for the treatment of erectile dysfunction prednisolone drops eye . (onlinehome.us)
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  • Researchers from Japan reported the case of 3 patients with aquaporin-4-positive neuromyelitis optica spectrum disorder (AQP4+NMOSD) whose prednisolone dose was rapidly and successfully tapered down following satralizumab treatment. (rarediseaseadvisor.com)
  • The rapid prednisolone tapering method described here seems adequate, and the data suggests that satralizumab may be an effective monotherapy for the treatment of NMOSD. (rarediseaseadvisor.com)
  • NMOSD relapses are usually common with prednisolone treatment of 10 mg per day or less. (rarediseaseadvisor.com)
  • With only few case studies published on SARS-CoV-2 infection in patients with rheumatic diseases, we report a 25-year-old male who developed moderate coronavirus disease 2019 (COVID-19) with fever, mild dyspnea, and no major complications despite having received high-dose prednisolone, cyclophosphamide, and rituximab for the treatment of highly active, life-threatening eosinophilic granulomatosis with polyangiitis (EGPA). (nih.gov)
Adverse effects2
  • Because absorption from the eye is limited, ophthalmic prednisolone would not be expected to cause any adverse effects in breastfed infants. (nih.gov)
  • Sorry if my doctor to do it made Do not stop adverse effects on on a buy prednisolone for dogs survival. (grey-panthers.it)
Orally1
  • Seven women were given 5 mg of radiolabeled prednisolone orally. (nih.gov)
Patients3
  • However, none of the 3 patients reported here relapsed following prednisolone tapering, suggesting that satralizumab may contribute to the prevention of relapses. (rarediseaseadvisor.com)
  • A total of 19 Duchenne muscular dystrophy (DMD) patients were recruited for randomized controlled study to see the effect of prednisolone in the natural course of the disease process. (who.int)
  • Prednisolone was given in 10 patients (study group) in a dose of 0.75 mg/kg for six months. (who.int)
Pharmacy4
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Medications1
  • Prednisolone is used alone or with other medications to treat the symptoms of low corticosteroid levels (lack of certain substances that are usually produced by the body and are needed for normal body functioning). (medlineplus.gov)
Successfully1
  • We report three cases of OP associated with rheumatoid arthritis (RA) successfully treated with clarithromycin (CAM) and prednisolone (PSL). (go.jp)
Price1
  • The lowest price on PharmacyChecker.com for prednisolone acetate 0.5% is $4.69 per dropperette for 20 dropperettes at PharmacyChecker-accredited online pharmacies. (pharmacychecker.com)
Immune1
  • Prednisolone inhibits inflammatory reactions associated with the disease by suppressing key components of the immune system. (medscape.com)
Symptoms1
  • Prednisolone is also sometimes used to treat symptoms from certain types of cancer. (medlineplus.gov)
Blood2
  • There are a possible to predict of my characters find out buy prednisolone for dogs blood will need the antioxidant protection often. (grey-panthers.it)
  • Prednisolone reduced blood perfusion and skin erythema following 48 h of IMQ application (95% CI [-26.4%, -4.3%], p = 0.0111 and 95% CI [-7.96, -2.13], p = 0.0016). (bvsalud.org)
Products1
  • Prednisolone acetate and difluprednate are the two main products for this purpose. (bmj.com)
Drug1
  • In this trial, researchers looked at a type of targeted cancer drug called custirsen (OGX-011) with cabazitaxel and a steroid called prednisolone . (cancerresearchuk.org)
Cancer2
  • This trial looked at custirsen with cabazitaxel and prednisolone for men who had prostate cancer that had spread and other treatments were no longer working. (cancerresearchuk.org)
  • This trial showed that custirsen, cabazitaxel and prednisolone was not better than cabazitaxel and prednisolone for prostate cancer that had spread. (cancerresearchuk.org)