A glucocorticoid with the general properties of the corticosteroids. It is the drug of choice for all conditions in which routine systemic corticosteroid therapy is indicated, except adrenal deficiency states.
A group of CORTICOSTEROIDS that affect carbohydrate metabolism (GLUCONEOGENESIS, liver glycogen deposition, elevation of BLOOD SUGAR), inhibit ADRENOCORTICOTROPIC HORMONE secretion, and possess pronounced anti-inflammatory activity. They also play a role in fat and protein metabolism, maintenance of arterial blood pressure, alteration of the connective tissue response to injury, reduction in the number of circulating lymphocytes, and functioning of the central nervous system.
Substances that reduce or suppress INFLAMMATION.
An immunosuppressive agent used in combination with cyclophosphamide and hydroxychloroquine in the treatment of rheumatoid arthritis. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), this substance has been listed as a known carcinogen. (Merck Index, 11th ed)
A PREDNISOLONE derivative with similar anti-inflammatory action.
Therapy with two or more separate preparations given for a combined effect.
Agents that suppress immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-CELLS or by inhibiting the activation of HELPER CELLS. While immunosuppression has been brought about in the past primarily to prevent rejection of transplanted organs, new applications involving mediation of the effects of INTERLEUKINS and other CYTOKINES are emerging.
Administration of high doses of pharmaceuticals over short periods of time.
A syndrome characterized by the acute onset of unilateral FACIAL PARALYSIS which progresses over a 2-5 day period. Weakness of the orbicularis oculi muscle and resulting incomplete eye closure may be associated with corneal injury. Pain behind the ear often precedes the onset of paralysis. This condition may be associated with HERPESVIRUS 1, HUMAN infection of the facial nerve. (Adams et al., Principles of Neurology, 6th ed, p1376)
The giving of drugs, chemicals, or other substances by mouth.
Tablets coated with material that delays release of the medication until after they leave the stomach. (Dorland, 28th ed)
A condition characterized by severe PROTEINURIA, greater than 3.5 g/day in an average adult. The substantial loss of protein in the urine results in complications such as HYPOPROTEINEMIA; generalized EDEMA; HYPERTENSION; and HYPERLIPIDEMIAS. Diseases associated with nephrotic syndrome generally cause chronic kidney dysfunction.
A synthetic anti-inflammatory glucocorticoid derived from CORTISONE. It is biologically inert and converted to PREDNISOLONE in the liver.
A method of studying a drug or procedure in which both the subjects and investigators are kept unaware of who is actually getting which specific treatment.
The main glucocorticoid secreted by the ADRENAL CORTEX. Its synthetic counterpart is used, either as an injection or topically, in the treatment of inflammation, allergy, collagen diseases, asthma, adrenocortical deficiency, shock, and some neoplastic conditions.
A cyclic undecapeptide from an extract of soil fungi. It is a powerful immunosupressant with a specific action on T-lymphocytes. It is used for the prophylaxis of graft rejection in organ and tissue transplantation. (From Martindale, The Extra Pharmacopoeia, 30th ed).
Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the LIVER to form the active aldophosphamide. It has been used in the treatment of LYMPHOMA and LEUKEMIA. Its side effect, ALOPECIA, has been used for defleecing sheep. Cyclophosphamide may also cause sterility, birth defects, mutations, and cancer.
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
A solution or compound that is introduced into the RECTUM with the purpose of cleansing the COLON or for diagnostic procedures.
A syndrome in the elderly characterized by proximal joint and muscle pain, high erythrocyte sedimentation rate, and a self-limiting course. Pain is usually accompanied by evidence of an inflammatory reaction. Women are affected twice as commonly as men and Caucasians more frequently than other groups. The condition is frequently associated with GIANT CELL ARTERITIS and some theories pose the possibility that the two diseases arise from a single etiology or even that they are the same entity.
Unsaturated pregnane derivatives containing two keto groups on side chains or ring structures.
A drug that is used in the management of inflammatory bowel diseases. Its activity is generally considered to lie in its metabolic breakdown product, 5-aminosalicylic acid (see MESALAMINE) released in the colon. (From Martindale, The Extra Pharmacopoeia, 30th ed, p907)
A glucocorticoid given orally, parenterally, by local injection, by inhalation, or applied topically in the management of various disorders in which corticosteroids are indicated. Its lack of mineralocorticoid properties makes betamethasone particularly suitable for treating cerebral edema and congenital adrenal hyperplasia. (From Martindale, The Extra Pharmacopoeia, 30th ed, p724)
Time schedule for administration of a drug in order to achieve optimum effectiveness and convenience.
An antitumor alkaloid isolated from VINCA ROSEA. (Merck, 11th ed.)
A group of corticosteroids bearing a hydroxy group at the 11-position.
A chronic systemic disease, primarily of the joints, marked by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. Etiology is unknown, but autoimmune mechanisms have been implicated.
Drugs that cannot be sold legally without a prescription.
The state of being free from intrusion or disturbance in one's private life or affairs. (Random House Unabridged Dictionary, 2d ed, 1993)
Insurance providing for payment of services rendered by the pharmacist. Services include the preparation and distribution of medical products.
The amount that a health care institution or organization pays for its drugs. It is one component of the final price that is charged to the consumer (FEES, PHARMACEUTICAL or PRESCRIPTION FEES).
Directions written for the obtaining and use of DRUGS.
The protection of genetic information about an individual, family, or population group, from unauthorized disclosure.
Pharmacy services accessed via electronic means.
Facilities for the preparation and dispensing of drugs.
The privacy of information and its protection against unauthorized disclosure.
Drugs manufactured and sold with the intent to misrepresent its origin, authenticity, chemical composition, and or efficacy. Counterfeit drugs may contain inappropriate quantities of ingredients not listed on the label or package. In order to further deceive the consumer, the packaging, container, or labeling, may be inaccurate, incorrect, or fake.
Solid dosage forms, of varying weight, size, and shape, which may be molded or compressed, and which contain a medicinal substance in pure or diluted form. (Dorland, 28th ed)
Voluntary cooperation of the patient in taking drugs or medicine as prescribed. This includes timing, dosage, and frequency.
Laws and regulations, pertaining to the field of pharmacy, proposed for enactment or enacted by a legislative body.
Dilation of pupils to greater than 6 mm combined with failure of the pupils to constrict when stimulated with light. This condition may occur due to injury of the pupillary fibers in the oculomotor nerve, in acute angle-closure glaucoma, and in ADIE SYNDROME.
The practice of compounding and dispensing medicinal preparations.
A glucocorticoid employed, usually as eye drops, in the treatment of allergic and inflammatory conditions of the eye. It has also been used topically in the treatment of various skin disorders. (From Martindale, The Extra Pharmacopoeia, 30th ed, p732)
Social welfare organizations with programs designed to assist individuals in need.
Reductions in all or any portion of the costs of providing goods or services. Savings may be incurred by the provider or the consumer.
A board-certified specialty of VETERINARY MEDICINE, requiring at least four years of special education, training, and practice of veterinary surgery after graduation from veterinary school. In the written, oral, and practical examinations candidates may choose either large or small animal surgery. (From AVMA Directory, 43d ed, p278)
The appearance of the face that is often characteristic of a disease or pathological condition, as the elfin facies of WILLIAMS SYNDROME or the mongoloid facies of DOWN SYNDROME. (Random House Unabridged Dictionary, 2d ed)
Messages between computer users via COMPUTER COMMUNICATION NETWORKS. This feature duplicates most of the features of paper mail, such as forwarding, multiple copies, and attachments of images and other file types, but with a speed advantage. The term also refers to an individual message sent in this way.
Mechanical food dispensing machines.
The guidelines and policy statements set forth by the editor(s) or editorial board of a publication.
The profession of writing. Also the identity of the writer as the creator of a literary production.
A publication issued at stated, more or less regular, intervals.
The functions and activities carried out by the U.S. Postal Service, foreign postal services, and private postal services such as Federal Express.
A loose confederation of computer communication networks around the world. The networks that make up the Internet are connected through several backbone networks. The Internet grew out of the US Government ARPAnet project and was designed to facilitate information exchange.

Acute haemodynamic and proteinuric effects of prednisolone in patients with a nephrotic syndrome. (1/2898)

BACKGROUND: Administration of prednisolone causes an abrupt rise in proteinuria in patients with a nephrotic syndrome. METHODS: To clarify the mechanisms responsible for this increase in proteinuria we have performed a placebo controlled study in 26 patients with a nephrotic syndrome. Systemic and renal haemodynamics and urinary protein excretion were measured after prednisolone and after placebo. RESULTS: After i.v. administration of 125-150 mg prednisolone total proteinuria increased from 6.66+/-4.42 to 9.37+/-6.07 mg/min (P<0.001). By analysing the excretion of proteins with different charge and weight (albumin, transferrin, IgG, IgG4 and beta2-microglobulin) it became apparent that the increase of proteinuria was the result of a change in size selectivity rather than a change in glomerular charge selectivity or tubular protein reabsorption. Glomerular filtration rate rose from 83+/-34 ml to 95+/-43 ml/min (P<0.001) after 5 h, whereas effective renal plasma flow and endogenous creatinine clearance remained unchanged. As a result filtration fraction was increased, compatible with an increased glomerular pressure, which probably contributes to the size selectivity changes. Since corticosteroids affect both the renin-angiotensin system and renal prostaglandins, we have evaluated the effects of prednisolone on proteinuria after pretreatment with 3 months of the angiotensin-converting enzyme inhibitor lisinopril or after 2 weeks of the prostaglandin synthesis inhibitor indomethacin. Neither drug had any effect on prednisolone-induced increases of proteinuria. CONCLUSIONS: Prednisolone increases proteinuria by changing the size selective barrier of the glomerular capillary. Neither the renin-angiotensin axis nor prostaglandins seem to be involved in these effects of prednisolone on proteinuria.  (+info)

Primary biliary cirrhosis associated with membranous glomerulonephritis. (2/2898)

A 33-year-old woman was admitted to our department for evaluation of liver dysfunction and proteinuria. A liver biopsy specimen showed ductular proliferation and moderate portal fibrosis indicating stage II primary biliary cirrhosis. A renal biopsy specimen showed mild to moderate mesangial cell proliferation without crescent formation or interstitial nephritis. Immunofluorescent staining revealed deposition of immunoglobulin G (IgG), third component of complement (C3), and Clq on glomerular basement membranes. The findings indicated stage I membranous glomerulonephritis. Administration of ursodesoxycholic acid together with prednisolone, azathioprine, and dipyridamole decreased proteinuria and improved cholestatic liver dysfunction.  (+info)

Effective control of Epstein-Barr virus-related hemophagocytic lymphohistiocytosis with immunochemotherapy. Histiocyte Society. (3/2898)

The familial form of hemophagocytic lymphohistiocytosis (HLH) is a lethal disorder. Although the prognosis for Epstein-Barr virus-associated HLH (EBV-HLH) remains uncertain, numerous reports indicate that it can also be fatal in a substantial proportion of cases. We therefore assessed the potential of immunochemotherapy with a core combination of steroids and etoposide to control EBV-HLH in 17 infants and children who met stringent diagnostic criteria for this reactive disorder of the mononuclear phagocyte system. Treatment of life-threatening emergencies was left to the discretion of participating investigators and typically included either intravenous Ig or cyclosporin A (CSA). Five patients (29%) entered complete remission during the induction phase (1 to 2 months), whereas 10 others (57%) required additional treatment to achieve this status. In 2 cases, immunochemotherapy was ineffective, prompting allogeneic bone marrow transplantation. Severe but reversible myelosuppression was a common finding; adverse late sequelae were limited to epileptic activity in one child and chronic EBV infection in 2 others. Fourteen of the 17 patients treated with immunochemotherapy have maintained their complete responses for 4+ to 39+ months (median, 15+ months), suggesting a low probability of disease recurrence. These results provide a new perspective on EBV-HLH, showing effective control (and perhaps cure) of the majority of EBV-HLH cases without bone marrow transplantation, using steroids and etoposide, with or without immunomodulatory agents.  (+info)

Th1 and Th2 cytokine mRNA profiles in childhood nephrotic syndrome: evidence for increased IL-13 mRNA expression in relapse. (4/2898)

Idiopathic nephrotic syndrome of childhood is thought to be associated with T lymphocyte dysfunction often triggered by viral infections, with the production of circulating factor(s) resulting in proteinuria. In view of the conflicting evidence of T cell activation and Th1 or Th2 pattern of cytokine synthesis in this disease, this study examined the mRNA expression of interleukin-2 (IL-2), interferon-gamma, IL-4, and IL-13 from CD4+ and CD8+ T cells in steroid-responsive nephrotic patients in relapse and remission. Fifty-five children with steroid-responsive nephrotic syndrome were included in this study, together with 34 normal controls and 24 patient controls with viral infections. RNA was isolated from purified CD4+ or CD8+ cells from peripheral blood and subjected to reverse transcription-PCR. Cytokine mRNA expression was measured semiquantitatively, and a cytokine index was derived from densitometric readings, with cyclophilin as the housekeeping gene. Both cross-sectional and paired data showed an increased CD4+ and CD8+ IL-13 mRNA expression in patients with nephrotic relapse as compared to remission, normal, and patient controls (P < 0.008). This was also associated with increased cytoplasmic IL-13 expression in phorbol myristate acetate/ionomycin-activated CD3+ cells (6.66+/-3.39%) from patients with nephrotic relapse compared to remission (2.59+/-1.35%) (P < 0.0001). However, there was no significant difference in CD4+ or CD8+ IL-2, interferon-gamma and IL-4 mRNA expression. IL-13 is an important T cell cytokine with anti-inflammatory and immunomodulatory functions on B cells and monocytes. It is conceivable that IL-13 may act on monocytes to produce vascular permeability factor(s) involved in the pathogenesis of proteinuria in patients with relapse nephrotic syndrome.  (+info)

A case of eosinophilic myocarditis complicated by Kimura's disease (eosinophilic hyperplastic lymphogranuloma) and erythroderma. (5/2898)

This report describes a patient with eosinophilic myocarditis complicated by Kimura's disease (eosinophilic hyperplastic lymphogranuloma) and erythroderma. A 50-year-old man presented with a complaint of precordial pain. However, the only abnormal finding on examinatioin was eosinophilia (1617 eosinophils/microl). Three years later, the patient developed chronic eczema, and was diagnosed with erythroderma posteczematosa. One year later, a tumor was detected in the right auricule, and a diagnosis of Kimura's disease was made, based on the biopsy findings. The patient developed progressive dyspnea 6 months later and was found to have cardiomegaly and a depressed left ventricular ejection fraction (17%). A diagnosis of eosinophilic myocarditis was made based on the results of a right ventricular endomyocardial biopsy. The eosinophilic myocarditis and erythrodrema were treated with steroids with improvement of both the eosinophilia and left ventricular function.  (+info)

Serum lipoprotein(a) and apolipoprotein(a) phenotypes in patients with rheumatoid arthritis. (6/2898)

OBJECTIVE: To determine serum lipoprotein(a) (Lp[a]) concentrations and to analyze the apolipoprotein(a) (Apo[a]) phenotype in patients with rheumatoid arthritis (RA). METHODS: The subjects included 131 patients with RA and 200 healthy control subjects. Serum Lp(a) concentrations were measured by enzyme-linked immunosorbent assay, and the Apo(a) phenotype was determined by immunoblotting. HLA-DR typing was also done. RESULTS: The mean serum Lp(a) level was significantly higher (P < 0.001) in the RA patients (27.5 mg/dl) than in the controls (15.0 mg/dl). The S3 allele was found in 70.0% of the patients versus 39.5% of the controls (P < 0.001). There was no significant difference in HLA-DR4 positivity between patients with and without the S3 phenotype. CONCLUSION: The serum Lp(a) level was increased in patients with RA, possibly partly because of S3 phenotype predominance.  (+info)

Effective immunosuppressive therapy in a patient with primary pulmonary hypertension. (7/2898)

The case history is described of a young woman who presented with primary pulmonary hypertension and non-specific inflammatory signs. The patient received prolonged immunosuppressive treatment with low dose methotrexate and prednisone without any vasodilator agent. After one year the pulmonary artery pressure fell from a mean value of 47 mm Hg to 30 mm Hg and there was a corresponding clinical response. This case suggests that, in patients with pulmonary hypertension of unknown origin, immunopathogenetic factors should be sought in order to consider the utility of immunosuppressive therapy.  (+info)

A pharmacoeconomic analysis of rimexolone for the treatment of ophthalmic inflammatory conditions. (8/2898)

Topical steroids are the standard first-line therapy for treating ophthalmic inflammatory conditions. However, potent ophthalmic steroids can lead to an elevation of intraocular pressure (IOP), which can result in greater medical resource utilization and increased costs. We have developed a decision analysis model from a societal perspective to evaluate the costs and consequences of the treatment of ophthalmic inflammatory conditions with two potent topical steroids: prednisolone and rimexolone. Data for the model are based on information from clinical trials, national data-bases, published literature, and responses by ophthalmologists to a questionnaire on treatment patterns for elevated IOP. Three steroid-responsive conditions are examined separately with the model: uveitis; postoperative inflammation following cataract surgery; and other ophthalmic inflammatory conditions (blepharitis, episcleritis, postoperative refractive surgery, and corneal transplant). The model evaluates patients with acute conditions versus those with chronic conditions and those with mild to moderate elevation of IOP versus those with severe elevation of IOP. Although the unit cost of rimexolone is higher than that of prednisolone, use of rimexolone leads to cost savings because the incidence of elevated IOP is decreased. If rimexolone is used instead of prednisolone for the treatment of ophthalmic inflammatory conditions, the estimated cost saved (at 1995 AWP prices) is approximately $10 million across the entire US population. The savings across the health maintenance organization population on an annualized basis is approximately $3.9 million. Even if rimexolone were priced higher than current market charges (at 130% to 150% of the AWP of prednisolone), cost savings ranging from the $2.9 million to $720,000 would accrue with use of rimexolone compared with prednisolone. However if, rimexolone were priced at 160% of the AWP of prednisolone, its use would incur an additional cost of $300,000. The primary medical resource utilized in treating elevated IOP in ophthalmic inflammatory conditions is physician visits. Medications are responsible for only one-fifth to one-third of the total cost of treating elevated IOP. This analysis indicates that rimexolone is associated with decreased medical resource utilization and cost savings to the entire healthcare system.  (+info)

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TY - JOUR. T1 - Efficacy of perioperative high-dose prednisolone therapy during thymectomy in myasthenia gravis patients. AU - Yamada, Yoshito. AU - Yoshida, Shigetoshi. AU - Suzuki, Hidemi. AU - Tagawa, Tetsuzo. AU - Iwata, Takekazu. AU - Mizobuchi, Teruaki. AU - Kawaguchi, Naoki. AU - Yoshino, Ichiro. PY - 2013/12/10. Y1 - 2013/12/10. N2 - Background: This study aimed to investigate the benefits of administering perioperative high-dose prednisolone in conjunction with thymectomy in patients with myasthenia gravis. Methods: We retrospectively reviewed data from patients with Myasthenia Gravis Foundation of America Clinical Class I to IIIB who had undergone an extended thymectomy between 1992 and 2009. Perioperative high-dose prednisolone was administered at starting doses of 10 to 20 mg and escalated up to 100 mg on alternate days. The treatment group comprised 70 patients receiving perioperative high-dose prednisolone, whereas the control group included 61 patients not treated with ...
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OBJECTIVE: The metabolic effects of low-dose prednisolone and optimal management of glucocorticoid-induced diabetes are poorly characterized. The aims were to investigate the acute effects of low-dose prednisolone on carbohydrate metabolism and whether long-term low-dose prednisolone administration increases visceral adiposity, amplifying metabolic perturbations. RESEARCH DESIGN AND METHODS: Subjects with inflammatory rheumatologic disease without diabetes mellitus were recruited. Nine subjects (age, 59 +/- 11 years) not using oral glucocorticoids were studied before and after a 7- to 10-day course of oral prednisolone 6 mg daily. Baseline data were compared with 12 subjects (age, 61 +/- 8 years) using continuous long-term prednisolone (6.3 +/- 2.2 mg/day). Basal endogenous glucose production (EGP) was estimated by 6,6-(2)H2 glucose infusion, insulin sensitivity was estimated by two-step hyperinsulinemic-euglycemic clamp, insulin secretion was estimated by intravenous glucose tolerance test, and adipose
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TY - JOUR. T1 - METHOTREXATE AND LOW DOSE PREDNISOLONE DOWNREGULATE OSTEOCLAST FUNCTION IN MONOCYTES FROM EARLY RHEUMATOID ARTHRITIS PATIENTS. AU - Perpetuo, I. P.. AU - Caetano-Lopes, J.. AU - Rodrigues, A. M.. AU - Campanilho-Marques, R.. AU - Ponte, C.. AU - Canhao, H.. AU - Ainola, M.. AU - Fonseca, J. E.. PY - 2017/6. Y1 - 2017/6. U2 - 10.1136/annrheumdis-2017-eular.6935. DO - 10.1136/annrheumdis-2017-eular.6935. M3 - Meeting Abstract. VL - 76. SP - 1080. EP - 1080. JO - Annals of the rheumatic diseases. JF - Annals of the rheumatic diseases. SN - 0003-4967. ER - ...
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The study investigates patients with suspected polymyalgia rheumatica (PMR). For Patients where the PMR diagnosis is dismissed, the study terminates after the first visit. Patients diagnosed with PMR will be treated with prednisolone with taper corresponding to usual care. At baseline all patients will have medical history taken, physical examination, blood drawn, Synacthen® test, PET/CT, and ultrasound performed. Physical examination, PET/CT, and ultrasound are repeated after 8 weeks of prednisolone treatment while the patients iare on 10 mg prednisolone as well as after prednisolone taper two weeks later, where Synachten® test is also performed. After 10 weeks prednisolone is restarted at 10 mg and the patient is followed by their general practitioner or at the department of rheumatology, where prednisolone is tapered according to usual care. Patients are invited to a follow up visit after one year ...
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Introduction: Effective treatment for neuralgic amyotrophy (NA), a disabling brachial plexus syndrome of supposed immuno-mediated origin, is currently lacking. Given the circumstantial evidence of a beneficial effect of prednisolone on pain and paresis, this report evaluates the effects of prednisolone treatment administered in the acute phase in a retrospective case series of 50 NA patients.. Methods: Baseline variables (e.g. age, sex, type of NA, and number of attacks), treatment variables (e.g. time until treatment, regimen, and use of analgesics), and outcome measures (e.g. duration and severity of pain, time course and severity of paresis, and functional outcome) were statistically analyzed and compared to an historical control group of 203 untreated NA patients.. Results: The baseline characteristics of the two patient groups were comparable. Median time until initial pain relief was lower in the study group (12.5 days vs. 20.5 days) and a significantly higher percentage already recovered ...
Importance Oral glucocorticoid treatment increases fracture risk, and evidence is lacking regarding the efficacy of alendronate to protect against hip fracture in older patients using glucocorticoids.Objective To investigate whether alendronate treatment in older patients using oral prednisolone is associated with decreased hip fracture risk and adverse effects.Design, Setting, and Participants Retrospective cohort study using a national database (N = 433 195) of patients aged 65 years or older undergoing a health evaluation (baseline) at Swedish health care facilities; 1802 patients who were prescribed alendronate after at least 3 months of oral prednisolone treatment (≥5 mg/d) were identified. Propensity score matching was used to select 1802 patients without alendronate use from 6076 patients taking prednisolone with the same dose and treatment time criteria. Follow-up occurred between January 2008 and December 2014.Exposures Alendronate vs no alendronate use; no patients had previously ...
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Background: The existing clinical trials have shown that topical corticosteroids are often effective in the management of oral inflammatory diseases. The purpose of this study was to compare the effectiveness and safety of a new mucoadhesive prednisolone tablet with that of triamcinolone acetonid paste in the management of oral lesions such as RAS-EM -pemphigus vulgaris-recurrent intraoral herpes -OLP and chemical burn.. Methods: In this randomized comparative study, 60 consecutive patients with oral lesions were recruited. The patients were divided into 2 groups, one receiving topical triamcinolone acetonid 0.1% paste and the other prednisolone 5 mg mucoadhesive tablet for 2 weeks.. Results: The profiles of mean lesion sizes and mean pain measures did not show any difference between the prednisolone and triamcinolone groups.. Conclusion: It was found that prednisolone 5mg table is useful as triamcinolone paste in the treatment of oral inflammatory lesions with minimal side effects.. ...
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TY - JOUR. T1 - Prednisolone-induced beta cell dysfunction is associated with impaired endoplasmic reticulum homeostasis in INS-1E cells. AU - Linssen, Margot M L. AU - van Raalte, Daniel H. AU - Toonen, Erik J M. AU - Alkema, Wynand. AU - van der Zon, Gerard C. AU - Dokter, Wim H. AU - Diamant, Michaela. AU - Guigas, Bruno. AU - Ouwens, D Margriet. N1 - Copyright © 2011 Elsevier Inc. All rights reserved.. PY - 2011/11. Y1 - 2011/11. N2 - Glucocorticoids (GCs), such as prednisolone (PRED), are widely prescribed anti-inflammatory drugs, but their use may induce glucose intolerance and diabetes. GC-induced beta cell dysfunction contributes to these diabetogenic effects through mechanisms that remain to be elucidated. In this study, we hypothesized that activation of the unfolded protein response (UPR) following endoplasmic reticulum (ER) stress could be one of the underlying mechanisms involved in GC-induced beta cell dysfunction. We report here that PRED did not affect basal insulin release but ...
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18/08/2017: Internal edit. 14/11/2016: The trial participating centres have been added. 11/11/2016: The overall trial end date has been updated from 29/02/2012 to 01/03/2016 and the recruitment end date has been updated from 29/02/2012 to 19/07/2016. In addition, the publication and dissemination plan and availability of participant level data has been added. 21/07/2016: Publication reference added. 06/06/2016: Publication reference added. 25/01/2016: Publication reference added. 16/02/2012: The following changes were made to the trial record: 1. The target number of participants was reduced from 1240 to 618 evaluable patients, due to a revised statistical analysis plan as per Protocol V10. 2. The study design was changed from Phase III randomised controlled feasibility trial to Phase III randomised controlled trial. 3. The overall trial end date was changed from 28/02/2013 to 29/02/2012. 15/02/2011: The target number of participants was changed from 300 to 1240 split into 4 groups. ...
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We have investigated the effect of long-term glucocorticoid (GC) administration on bone turnover in two frequently used mouse strains; C57BL/6J and CD1, in order to assess the influence of their genetic background on GC-induced osteoporosis (GIO). GIO was induced in 12 weeks old female C57BL/6J and CD1 mice by subcutaneous insertion of long-term release prednisolone or placebo pellets. Biomechanical properties as assessed by three point bent testing revealed that femoral elasticity and strength significantly decreased in CD1 mice receiving GC, whereas C57BL/6J mice showed no differences between placebo and prednisolone treatment. Bone turnover assessed by microcomputer tomography revealed that contrary to C57BL/6J mice, prednisolone treated CD1 mice developed osteoporosis. In vitro experiments have underlined that, at a cellular level, C57BL/6J mice osteoclasts and osteoblasts were less responsive to GC treatment and tolerated higher doses than CD1 cells. Whilst administration of long-term release
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The Lancet has published the results of a study that aimed to assess the efficacy of prednisolone compared to naproxen in treating gout.. The rationale for the study was that non-steroidal anti-inflammatory drugs (NSAIDs) such as naproxen have gastrointestinal, cardiovascular and renal side effects and colchicine has gastrointestinal side effects. Oral corticosteroids may therefore be a suitable alternative to drugs.. 120 patients were recruited to the study and randomly assigned to five days treatment with 35mg of prednisolone daily or 500mg of naproxen twice daily. Efficacy was assessed using a 100mm visual analogue scale.. Pain score was reduced after 90 hours in both groups, by 44.7mm in the prednisolone group and by 46.0mm in the naproxen group. The difference was 1.3mm (95% CI -9.8 - 7.1) and not significant. Adverse events were similar in the two groups, were minor and resolved by 3 week follow up.. The authors conclude that, oral prednisolone and naproxen are equally effective in the ...
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Prophylactic antibiotic therapy may be indicated in cases of IBD. Criteria that determine antibiotic use include the presence of peripheral leukocytosis, elevated hepatic or pancreatic enzymes on the biochemical profile, bleeding from the GI tract, suspected bacterial overgrowth or stagnant loop syndrome, and severe mucosal inflammatory changes with a neutrophilic component. Two antibiotics that are often used in combination with prednisolone therapy are amoxicillin (Amoxi-tabs) and metronidazole (Flagyl). Amoxicillin has both aerobic and anaerobic bactericidal effects and is dosed at 5 to 10 mg/lb b.i.d. for 10 to 14 days or as long as deemed necessary by the veterinarian. Metronidazole is primarily an anaerobic bactericidal antibiotic and often shows dramatic clinical response in combination with prednisolone therapy in refractory IBD cases. Metroniclazole also has an antiprotozoan effect and aids in inhibiting cell-mediated immune responses in the intestinal tract. For IBD therapy ...
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TY - JOUR. T1 - Aldosterone and prednisolone control of cochlear function in MRL/MpJ-Faslpr autoimmune mice. AU - Trune, Dennis R.. AU - Kempton, J. Beth. N1 - Funding Information: Research supported by NIH-NIDCD R01 DC03573, NIH-NIDCD R21 DC03955, and VA RR&D National Center for Rehabilitative Auditory Research RCTR 597-0160, Portland VAMC. PY - 2001. Y1 - 2001. N2 - Recently this laboratory showed aldosterone, a mineralocorticoid that only enhances sodium transport, was as effective as the glucocorticoid prednisolone in restoring cochlear function in autoimmune mice. To further test this relationship between sodium transport and autoimmune hearing loss, dosage comparisons were made of prednisolone and aldosterone control of the auditory dysfunction in autoimmune MRL/MpJ-Faslpr mice. Mice were tested at 2 months of age to establish baseline auditory brainstem response (ABR) thresholds, hematocrit, serum immune complexes, and anti-nuclear antibodies. Mice were then given different doses of ...
TY - JOUR. T1 - Comparative evaluation of prednisolone 5MG tablets marketed in Bangladesh. AU - Morshed, Nabila. AU - Sharmin, Shahana. PY - 2015. Y1 - 2015. N2 - The aim of the present study is to determine the quality and to correlate with other different brands of pharmaceutical products marketed in Bangladesh for the healthcare of patients suffering from different respiratory inflammation like asthma, and auto-immune disorders. The experiment is done to evaluate and compare the physicochemical equivalence of different brands of Prednisolone 5mg tablet. These tablets were tested through statistical methods in accordance with the BP and USP like weight variation, thickness, hardness, friability, disintegration, in-vitro dissolution and HPLC assay. The in vitro dissolution studies of Prednisolone 5 mg tablets were carried out in pH 7 distilled water for 30 minutes using USP-II method whose absorbance were taken at 246 nm using UV spectrophotometry. Six samples showed poor in-vitro dissolution ...
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Overall Study Design:. Structure:. This is a randomized, double-masked prospective study. The study medications will be masked and randomized by the outpatient pharmacy at Indiana University Hospital.. Duration:. Treatment duration: The duration of each subjects participation will be for up to 2 months after surgery. One hundred and two subjects will be enrolled over a twelve-month time span.. Controls:. Examiner, staff, and subjects are masked. Parallel group comparison.. Dosage/Dose Regimen/Instructions:. Subjects scheduled for glaucoma and/or cataract surgery will be recruited. Subjects may not be currently on any steroid or ophthalmic non-steroidal anti-inflammatory (NSAID) therapy for a minimum of 6 weeks prior to surgery. Subjects will be randomized to receive a dose of Pred Forte 1% (Allergan), Econopred Plus 1% (Alcon) or prednisolone acetate 1% (Falcon) four times a day starting immediately after finishing the surgery for two weeks, then twice a day for two more weeks. After 1 month of ...
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Results bDNA was quantified in 714 whole blood samples. There was no correlation between bDNA levels and baseline characteristics such as age and gender, nor with static markers of liver function such as MELD. Elevated bDNA levels were associated with development of infection within the first 7 days in patients treated with prednisolone (p = 0.001), and remained independently associated with the subsequent development of infection after multivariate analysis (p = 0.02). Importantly, bDNA levels were not associated with the development of infection in patients treated without prednisolone (p = 0.43).. Elevated bDNA levels were associated with death at 90 days (p = 0.05). Mortality in prednisolone treated patients was increased for patients with high bDNA compared to patients with low bDNA (hazard ratio 2; p = 0.02). Accordingly, patients with elevated bDNA were more likely to die if they were randomly allocated prednisolone therapy (OR 2.9, 95% CI 1.2-6.9, p = 0.02). We estimate that if patients ...
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Patients with chronic airflow obstruction were given a three-week course of prednisolone 40 mg per day. The basal plasma cortisol level and response to tetracosactrin were depressed after such a course. Basal plasma cortisol and corticotrophin (ACTH) levels were measured on five consecutive days after three weeks of treatment with prednisolone and were found to rise simultaneously to control levels within three days. Pituitary and adrenal functions were depressed for four days after short high dose courses of corticosteroids and patients may be at risk if they encounter stress during this time.. ...
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First diagnosis of polymyalgia in October 2014. After the diagnosis in the evening a dose of 25mg prednisolone. The next morning already a completely better condition, hardly any pain in the entire muscle and joint area. A new attitude to life. Dose was reduced by 2.5mg every 4 weeks with monthly blood control, especially CRP value, initially at & gt; 65mg / l, after 3 days already at & lt; 50mg / L, after 30 days CRP at & lt; 5mg / l. After 2 days hoarseness raged, which has not completely disappeared even when reduced to a maintenance dose of 7.5 mg. Renewed thrust in the NOV. 2015 with severe pain throughout the body and flu feeling despite a maintenance dose of 7.5mg. High dose, 50mg, for pain control. Positive effect within 24 hours.. ...
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It is important that the clinician formulate a treatment protocol based on a correlation of clinical course, laboratory and gross findings, and histologic findings rather than relying on histologic changes alone. Corticosteroids are the cornerstone of treatment for idiopathic inflammatory bowel disorders. Mild to moderate cases often respond to prednisone or prednisolone at a starting dose of 0.5 to 1 mg/lb divided twice daily for two to four weeks followed by a gradual decline in 50% increments at two week intervals. Cats with inflammatory changes graded as mild usually respond quite well to the lower dose and alternate day or every third day treatment can often be achieved by two to three months. Occasionally treatment can be discontinued altogether by three to six months.. If biopsies reveal disease that is moderate to severe a prednisolone dose of 1 to 2 mg/lb divided twice daily is used for the first 2 to 8 weeks or until clinical signs resolve. I do prefer to use prednisolone over ...
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Methods The trial included 164 active RA patients who were randomised to either COBRA therapy (prednisolone starting at 60 mg/day tapered to 7.5 mg/day in 6 weeks, MTX 7.5 mg/week and sulfasalazine 2 g/day; n=81) or COBRA light therapy (prednisolone starting at 30 mg/day tapered to 7.5 mg/day in 9 weeks and MTX escalated to 25 mg/week in 9 weeks; n=83) [3,4]. In an add-on study 36 resp. 39 patients underwent whole body DXA scans within 4 weeks ($≈ $baseline), 26 and 52 weeks after start of treatment. ...
Intravenous immunoglobin treatments can be used to support the patient's immune system as well as medication with Prednisolone ... ". "Prednisolone & Prednisone". "Cochlear Implants". 2015-08-18. Richards (1991). "Epstein syndrome: oral lesions ina patient ...
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Prednisolone gave a small reduction in mortality at 28 days but this did not reach significance, and there were no improvements ... "Prednisolone or pentoxifylline for alcoholic hepatitis". N. Engl. J. Med. 372 (17): 1619-28. doi:10.1056/NEJMoa1412278. PMID ... 32 or hepatic encephalopathy should be considered for treatment with prednisolone 40 mg daily for four weeks followed by a ... A large prospective study of over 1000 patients investigated whether prednisolone and pentoxifylline produced benefits when ...
Whalen, R. E.; Olsen, K. L. (1978). "Prednisolone modifies estrogen-induced sexual differentiation". Behavioral Biology. 24 (4 ...
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Prednisolone tablets may also be helpful. Legg-Calvé-Perthes Disease Imaging Author: Ali Nawaz Khan. Chief Editor: Felix S Chew ...
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Nakano, Y; Kohira, R; Yamazaki, H; Fujita, N; Fuchigami, T; Okubo, O; Harada, K (2001). "Hopkins syndrome: oral prednisolone ...
de Vrieze, E.; van Kessel, M. A. H. J.; Peters, H. M.; Spanings, F. A. T.; Flik, G.; Metz, J. R. (2014-02-01). "Prednisolone ...
"Van der Sande cleared after positive test for prednisolone". Cyclingnews. Future plc. Retrieved 29 April 2019. "Lotto Soudal". ... "Van der Sande cleared after positive test for prednisolone". Cyclingnews. Future plc. Retrieved 29 April 2019. "Positive doping ... the wrong nasal spray brand in the paperwork at the 2018 Six Days of Ghent where he returned a positive test for prednisolone, ...
... acetate suspension (Depo-Medrol) is a 6-methyl derivative of prednisolone that melts at 215 degrees Celsius ... Szefler SJ, Ebling WF, Georgitis JW, Jusko WJ (1986). "Methylprednisolone versus prednisolone pharmacokinetics in relation to ... Chemically, methylprednisolone is a synthetic pregnane steroid hormone derived from hydrocortisone and prednisolone. It belongs ... and prednisolone (11β,17α,21-trihydroxypregn-1,4-diene-3,20-dione). A variety of methylprednisolone esters with differing ...
Administration of prednisolone will allow the HbA1 to be detected. The alternative fructosamine test may be used in these ...
The associated asthma can be treated with desensitization and prednisolone. Amphotericin B, clotrimazole and S-fluorocytosine ...
On 3 September, Benito Ros Charral tested positive for Prednisolone and was eventually stripped of all results from the date of ... Wilmer Bravo of Venezuela tested positive for Prednisolone and Prednisone on 9 January 2006. The UCI summary of 'Decisions on ... Cénéric Racault of France tested positive for Prednisolone and Prednisone. The UCI summary of 'Decisions on Anti-Doping Rule ...
In Italy, prednisolone reduced average duration of symptoms from 9 weeks to 4 weeks, and these were severe cases. South African ... "Treatment of acute Sydenham's chorea with methyl-prednisolone pulse-therapy". Parkinsonism & Related Disorders. 11 (5): 327-330 ...
2) Corticosteroids: Oral steroids such as prednisolone are commonly used; however, side effects are common, and the horse may ...
The basis for most immunosuppressive regimens is prednisolone, a corticosteroid. Prednisolone suppresses the immune system, but ... Prednisolone alone is usually inadequate to prevent rejection of a transplanted kidney. Thus other, non-steroid ... The most common medication regimen today is a mixture of tacrolimus, mycophenolate, and prednisolone. Some recipients may ... The routine immunosuppressives are tacrolimus (Prograf), mycophenolate (Cellcept), and prednisolone; these drugs cost US$1,500 ...
"Prednisolone and cyclosporine A: effects on an experimental model of ancylostomiasis". Experimental Parasitology. 133 (1): 80- ...
Ballardie FW, Roberts IS (2002). "Controlled prospective trial of prednisolone and cytotoxics in progressive IgA nephropathy". ...
... , once confirmed, is generally treated with glucocorticoids such as prednisolone. If this is effective, the ...
Mucous membrane pemphigoid may be managed with medication (cyclophosphamide and prednisolone). Sarcoidosis is typically treated ...
"Comparison of prednisolone plus albendazole with prednisolone alone for treatment of patients with eosinophilic meningitis". ... Chotmongkol V (2006). "Treatment of eosinophilic meningitis with a combination of prednisolone and mebendazole". Am J Trop Med ... There is growing evidence of moderate quality that suggests corticosteroid therapy using prednisolone or dexamethasone has ... Although combination therapy using albendazole and prednisolone has no significant advantage compared to treatment using ...
... , also known as prednisolone 21-diethylaminoacetate, is a synthetic corticosteroid. It is or was a component of ...
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