A selective adrenergic alpha-1 antagonist used in the treatment of HEART FAILURE; HYPERTENSION; PHEOCHROMOCYTOMA; RAYNAUD DISEASE; PROSTATIC HYPERTROPHY; and URINARY RETENTION.
Drugs that bind to but do not activate alpha-adrenergic receptors thereby blocking the actions of endogenous or exogenous adrenergic agonists. Adrenergic alpha-antagonists are used in the treatment of hypertension, vasospasm, peripheral vascular disease, shock, and pheochromocytoma.
Drugs that bind to and block the activation of ADRENERGIC ALPHA-1 RECEPTORS.
One of the two major pharmacological subdivisions of adrenergic receptors that were originally defined by the relative potencies of various adrenergic compounds. The alpha receptors were initially described as excitatory receptors that post-junctionally stimulate SMOOTH MUSCLE contraction. However, further analysis has revealed a more complex picture involving several alpha receptor subtypes and their involvement in feedback regulation.
A subclass of alpha-adrenergic receptors that mediate contraction of SMOOTH MUSCLE in a variety of tissues such as ARTERIOLES; VEINS; and the UTERUS. They are usually found on postsynaptic membranes and signal through GQ-G11 G-PROTEINS.
A plant alkaloid with alpha-2-adrenergic blocking activity. Yohimbine has been used as a mydriatic and in the treatment of ERECTILE DYSFUNCTION.
Drugs that selectively bind to and activate alpha adrenergic receptors.
An imidazoline sympatholytic agent that stimulates ALPHA-2 ADRENERGIC RECEPTORS and central IMIDAZOLINE RECEPTORS. It is commonly used in the management of HYPERTENSION.
1,4-Diethylene dioxides. Industrial solvents. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), dioxane itself may "reasonably be anticipated to be a carcinogen." (Merck Index, 11th ed)
Precursor of epinephrine that is secreted by the adrenal medulla and is a widespread central and autonomic neurotransmitter. Norepinephrine is the principal transmitter of most postganglionic sympathetic fibers and of the diffuse projection system in the brain arising from the locus ceruleus. It is also found in plants and is used pharmacologically as a sympathomimetic.
The effects, both local and systemic, caused by the bite of SCORPIONS.
An alpha-1 adrenergic agonist used as a mydriatic, nasal decongestant, and cardiotonic agent.
Compounds that bind to and activate ADRENERGIC ALPHA-1 RECEPTORS.
Drugs that bind to but do not activate ADRENERGIC RECEPTORS. Adrenergic antagonists block the actions of the endogenous adrenergic transmitters EPINEPHRINE and NOREPINEPHRINE.
Cell-surface proteins that bind epinephrine and/or norepinephrine with high affinity and trigger intracellular changes. The two major classes of adrenergic receptors, alpha and beta, were originally discriminated based on their cellular actions but now are distinguished by their relative affinity for characteristic synthetic ligands. Adrenergic receptors may also be classified according to the subtypes of G-proteins with which they bind; this scheme does not respect the alpha-beta distinction.
Drugs that bind to and block the activation of ADRENERGIC ALPHA-2 RECEPTORS.
A nonselective alpha-adrenergic antagonist. It is used in the treatment of hypertension and hypertensive emergencies, pheochromocytoma, vasospasm of RAYNAUD DISEASE and frostbite, clonidine withdrawal syndrome, impotence, and peripheral vascular disease.
A benzodioxane-linked imidazole that has alpha-2 adrenoceptor antagonist activity.
A prazosin-related compound that is a selective alpha-1-adrenergic blocker.
An alpha-1 adrenergic agonist that causes prolonged peripheral VASOCONSTRICTION.
A direct acting sympathomimetic used as a vasoconstrictor to relieve nasal congestion. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1251)
An alpha-adrenergic antagonist with long duration of action. It has been used to treat hypertension and as a peripheral vasodilator.
A subclass of alpha-adrenergic receptors found on both presynaptic and postsynaptic membranes where they signal through Gi-Go G-PROTEINS. While postsynaptic alpha-2 receptors play a traditional role in mediating the effects of ADRENERGIC AGONISTS, the subset of alpha-2 receptors found on presynaptic membranes signal the feedback inhibition of NEUROTRANSMITTER release.
Dibenzoquinolines derived in plants from (S)-reticuline (BENZYLISOQUINOLINES).
A widely used non-cardioselective beta-adrenergic antagonist. Propranolol has been used for MYOCARDIAL INFARCTION; ARRHYTHMIA; ANGINA PECTORIS; HYPERTENSION; HYPERTHYROIDISM; MIGRAINE; PHEOCHROMOCYTOMA; and ANXIETY but adverse effects instigate replacement by newer drugs.
The physiological narrowing of BLOOD VESSELS by contraction of the VASCULAR SMOOTH MUSCLE.
Quantitative determination of receptor (binding) proteins in body fluids or tissue using radioactively labeled binding reagents (e.g., antibodies, intracellular receptors, plasma binders).
Compounds that bind to and activate ADRENERGIC ALPHA-2 RECEPTORS.
A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.
Arthropods of the order Scorpiones, of which 1500 to 2000 species have been described. The most common live in tropical or subtropical areas. They are nocturnal and feed principally on insects and other arthropods. They are large arachnids but do not attack man spontaneously. They have a venomous sting. Their medical significance varies considerably and is dependent on their habits and venom potency rather than on their size. At most, the sting is equivalent to that of a hornet but certain species possess a highly toxic venom potentially fatal to humans. (From Dorland, 27th ed; Smith, Insects and Other Arthropods of Medical Importance, 1973, p417; Barnes, Invertebrate Zoology, 5th ed, p503)
Use of electric potential or currents to elicit biological responses.
Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations or by parent x offspring matings carried out with certain restrictions. This also includes animals with a long history of closed colony breeding.
Drugs that bind to but do not activate beta-adrenergic receptors thereby blocking the actions of beta-adrenergic agonists. Adrenergic beta-antagonists are used for treatment of hypertension, cardiac arrhythmias, angina pectoris, glaucoma, migraine headaches, and anxiety.
Antisera used to counteract poisoning by animal VENOMS, especially SNAKE VENOMS.
A tricyclic dibenzazepine compound that potentiates neurotransmission. Desipramine selectively blocks reuptake of norepinephrine from the neural synapse, and also appears to impair serotonin transport. This compound also possesses minor anticholinergic activity, through its affinity to muscarinic receptors.
The relationship between the dose of an administered drug and the response of the organism to the drug.
Compounds in which a methyl group is attached to the cyano moiety.
The nonstriated involuntary muscle tissue of blood vessels.
The active sympathomimetic hormone from the ADRENAL MEDULLA. It stimulates both the alpha- and beta- adrenergic systems, causes systemic VASOCONSTRICTION and gastrointestinal relaxation, stimulates the HEART, and dilates BRONCHI and cerebral vessels. It is used in ASTHMA and CARDIAC FAILURE and to delay absorption of local ANESTHETICS.
Drugs that act on adrenergic receptors or affect the life cycle of adrenergic transmitters. Included here are adrenergic agonists and antagonists and agents that affect the synthesis, storage, uptake, metabolism, or release of adrenergic transmitters.
The interaction of two or more substrates or ligands with the same binding site. The displacement of one by the other is used in quantitative and selective affinity measurements.
PRESSURE of the BLOOD on the ARTERIES and other BLOOD VESSELS.
An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent.
The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065)
An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria. Reserpine inhibits the uptake of norepinephrine into storage vesicles resulting in depletion of catecholamines and serotonin from central and peripheral axon terminals. It has been used as an antihypertensive and an antipsychotic as well as a research tool, but its adverse effects limit its clinical use.
An act which constitutes the termination of a given instinctive behavior pattern or sequence.
A strain of albino rat developed at the Wistar Institute that has spread widely at other institutions. This has markedly diluted the original strain.
Arteries which arise from the abdominal aorta and distribute to most of the intestines.
A 9,10alpha-dihydro derivative of ERGOTAMINE. It is used as a vasoconstrictor, specifically for the therapy of MIGRAINE DISORDERS.
An adrenergic alpha-2 agonist used as a sedative, analgesic and centrally acting muscle relaxant in VETERINARY MEDICINE.
A direct-acting vasodilator that is used as an antihypertensive agent.
Drugs that inhibit the actions of the sympathetic nervous system by any mechanism. The most common of these are the ADRENERGIC ANTAGONISTS and drugs that deplete norepinephrine or reduce the release of transmitters from adrenergic postganglionic terminals (see ADRENERGIC AGENTS). Drugs that act in the central nervous system to reduce sympathetic activity (e.g., centrally acting alpha-2 adrenergic agonists, see ADRENERGIC ALPHA-AGONISTS) are included here.
One of two major pharmacologically defined classes of adrenergic receptors. The beta adrenergic receptors play an important role in regulating CARDIAC MUSCLE contraction, SMOOTH MUSCLE relaxation, and GLYCOGENOLYSIS.
A mixture of three different hydrogenated derivatives of ERGOTAMINE: DIHYDROERGOCORNINE; DIHYDROERGOCRISTINE; and DIHYDROERGOCRYPTINE. Dihydroergotoxine has been proposed to be a neuroprotective agent and a nootropic agent. The mechanism of its therapeutic actions is not clear, but it can act as an alpha-adrenergic antagonist and a dopamine agonist. The methanesulfonate salts of this mixture of alkaloids are called ERGOLOID MESYLATES.
The species Oryctolagus cuniculus, in the family Leporidae, order LAGOMORPHA. Rabbits are born in burrows, furless, and with eyes and ears closed. In contrast with HARES, rabbits have 22 chromosome pairs.
Drugs that block the transport of adrenergic transmitters into axon terminals or into storage vesicles within terminals. The tricyclic antidepressants (ANTIDEPRESSIVE AGENTS, TRICYCLIC) and amphetamines are among the therapeutically important drugs that may act via inhibition of adrenergic transport. Many of these drugs also block transport of serotonin.
A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.
Seven membered heterocyclic rings containing a NITROGEN atom.
A potent vasodilator agent with calcium antagonistic action. It is a useful anti-anginal agent that also lowers blood pressure.

alpha1-adrenergic receptor subtypes in human peripheral blood lymphocytes. (1/1153)

We investigated the expression of alpha1-adrenergic receptor subtypes in intact human peripheral blood lymphocytes using reverse transcription-polymerase chain reaction (RT-PCR) and radioligand binding assay techniques combined with antibodies against the three subtypes of alpha1-adrenergic receptors (alpha1A, alpha1B, and alpha1D). RT-PCR amplified in peripheral blood lymphocytes a 348-bp alpha1A-adrenergic receptor fragment, a 689-bp alpha1B-adrenergic receptor fragment, and a 540-bp alpha1D-adrenergic receptor fragment. Radioligand binding assay with [3H]prazosin as radioligand revealed a high-affinity binding with a dissociation constant value of 0. 65+/-0.05 nmol/L and a maximum density of binding sites of 175. 3+/-20.5 fmol/10(6) cells. The pharmacological profile of [3H]prazosin binding to human peripheral blood lymphocytes was consistent with the labeling of alpha1-adrenergic receptors. Antibodies against alpha1A-, alpha1B-, and alpha1D-receptor subtypes decreased [3H]prazosin binding to a different extent. This indicates that human peripheral blood lymphocytes express the three alpha1-adrenergic receptor subtypes. Of the three different alpha1-adrenergic receptor subtypes, the alpha1B is the most represented and the alpha1D, the least. Future studies should clarify the functional relevance of alpha1-adrenergic receptors expressed by peripheral blood lymphocytes. The identification of these sites may represent a step for evaluating whether they represent a marker of alpha1-adrenergic receptors in cardiovascular disorders or for assessing responses to drug treatment on these receptors.  (+info)

Neural modulation of cephalexin intestinal absorption through the di- and tripeptide brush border transporter of rat jejunum in vivo. (2/1153)

Intestinal absorption of beta-lactamine antibiotics (e.g., cefixime and cephalexin) has been shown to proceed through the dipeptide carrier system. In a previous study, nifedipine (NFP), an L-type calcium channel blocker, enhanced the absorption of cefixime in vivo but not in vitro, and it was suggested that neural mechanisms might be involved in the effect of NFP. The aim of the present study was to assess the involvement of the nervous system on the intestinal absorption of cephalexin (CFX). To investigate this, we used a single-pass jejunal perfusion technique in rats. NFP and diltiazem enhanced approximately 2-fold the plasma levels of CFX in treated rats versus untreated controls. NFP also increased approximately 2-fold the CFX level in portal plasma and increased urinary excretion of CFX, thus indicating that CFX did effectively increase CFX intestinal absorption. Perfusing high concentrations of dipeptides in the jejunal lumen competitively reduced CFX absorption and inhibited the enhancement of CFX absorption produced by NFP. Hexamethonium and lidocaine inhibited the effect of NFP, whereas atropine, capsaicin, clonidine, and isoproterenol enhanced CFX absorption by the same order of magnitude as NFP. Thus, complex neural networks can modulate the function of the intestinal di- and tripeptide transporter. Sympathetic noradrenergic fibers, intestinal sensory neurons, and nicotinic synapses are involved in the increase of CFX absorption produced by NFP.  (+info)

Transcriptional regulation of alpha1-adrenoceptor gene in the rat liver during different phases of sepsis. (3/1153)

Changes in alpha1-adrenoceptor (alpha1AR) gene expression in the rat liver during different phases of sepsis were studied. Sepsis was induced by cecal ligation and puncture (CLP). Septic rats exhibit two metabolically distinct phases: an initial hyperglycemic phase (9 h after CLP, early sepsis) followed by a hypoglycemic phase (18 h after CLP; late sepsis). The [3H]prazosin binding studies show that the density of alpha1AR was increased by 30% during the early phase while it was decreased by 24% during the late phase of sepsis. Western blot analyses reveal that alpha1AR protein level was elevated by 48% during early sepsis but was decreased by 55% during late sepsis. Northern blot analyses depict that the steady-state level of alpha1bAR mRNA was enhanced by 21% during the early phase but was declined by 29% during the late phase of sepsis. Nuclear run-off assays show that the transcription rate of alpha1bAR gene transcript was increased by 76% during early sepsis while it was decreased by 29% during late sepsis. The actinomycin D pulse-chase studies indicate that the half-life of alpha1bAR mRNA remained unaffected during the early and the late phases of sepsis. These findings demonstrate that during the early phase of sepsis, the increase in the rate of transcription of alpha1bAR gene paralleled with the elevations in the alpha1bAR mRNA abundance and alpha1AR protein level, while during the late phase of sepsis, the decrease in the rate of transcription of alpha1bAR gene coincided with the declines in the alpha1bAR mRNA abundance and the alpha1AR protein level in the rat liver. These observations indicate that the altered expression of alpha1AR genes in the rat liver during the progression of sepsis was regulated transcriptionally.  (+info)

Effects of heptanol on the neurogenic and myogenic contractions of the guinea-pig vas deferens. (4/1153)

1. The effects of the putative gap junction uncoupler, 1-heptanol, on the neurogenic and myogenic contractile responses of guinea-pig vas deferens were studied in vitro. 2. Superfusion of 2.0 mM heptanol for 20-30 min produced the following reversible changes in the biphasic neurogenic contractile response (8 trials): (i) suppression of both phases; (ii) delayed development of both the first as well as the second phase, accompanied by complete temporal separation of the two phases; (iii) prominent oscillations of force during the second (noradrenergic) phase only. 3. To eliminate prejunctional effects of heptanol, myogenic contractions were evoked by field stimulation of the vas in the presence of suramin (200 microM) and prazosin (1 microM). Heptanol (2.0 mM) abolished these contractions reversibly. 4. These results show that (i) heptanol inhibits both excitatory junction potential (EJP)-dependent and non EJP-dependent contractions of the vas; (ii) a postjunctional site of action of heptanol, probably intercellular uncoupling of smooth muscle cells, contributes to the inhibition of contraction.  (+info)

Spread of vasodilatation and vasoconstriction along feed arteries and arterioles of hamster skeletal muscle. (5/1153)

1. In arterioles of the hamster cheek pouch, vasodilatation and vasoconstriction can spread via the conduction of electrical signals through gap junctions between cells that comprise the vessel wall. However, conduction in resistance networks supplying other tissues has received relatively little attention. In anaesthetized hamsters, we have investigated the spread of dilatation and constriction along feed arteries and arterioles of the retractor muscle, which is contiguous with the cheek pouch. 2. When released from a micropipette, acetylcholine (ACh) triggered vasodilatation that spread rapidly along feed arteries external to the muscle and arterioles within the muscle. Responses were independent of changes in wall shear rate, perivascular nerve activity, or release of nitric oxide, indicating cell-to-cell conduction. 3. Vasodilatation conducted without decrement along unbranched feed arteries, yet decayed markedly in arteriolar networks. Thus, branching of the conduction pathway dissipated the vasodilatation. 4. Noradrenaline (NA) or a depolarizing KCl stimulus evoked constriction of arterioles and feed arteries of the retractor muscle that was constrained to the vicinity of the micropipette. This behaviour contrasts sharply with the conduction of vasodilatation in these microvessels and with the conduction of vasoconstriction elicited by NA and KCl in cheek pouch arterioles. 5. Focal electrical stimulation produced constriction that spread rapidly along feed arteries and arterioles. These responses were inhibited by tetrodotoxin or prazosin, confirming the release of NA along perivascular sympathetic nerves, which are absent from arterioles studied in the cheek pouch. Thus, sympathetic nerve activity co-ordinated the contraction of smooth muscle cells as effectively as the conduction of vasodilatation co-ordinated their relaxation. 6. In the light of previous findings in the cheek pouch, the properties of vasoconstriction and vasodilatation in feed arteries and arterioles of the retractor muscle indicate that substantive differences can exist in the nature of signal transmission along microvessels of tissues that differ in structure and function.  (+info)

Nitric oxide mediates sympathetic vasoconstriction at supraspinal, spinal, and synaptic levels. (6/1153)

The purposes of this study were to investigate the level of the sympathetic nervous system in which nitric oxide (NO) mediates regional sympathetic vasoconstriction and to determine whether neural mechanisms are involved in vasoconstriction after NO inhibition. Ganglionic blockade (hexamethonium), alpha1-receptor blockade (prazosin), and spinal section at T1 were used to study sympathetic involvement. NO was blocked with Nomega-nitro-L-arginine methyl ester (L-NAME). Regional blood flow in the mesenteric and renal arteries and terminal aorta was monitored by electromagnetic flowmetry in conscious rats. L-NAME (3-5 mg/kg iv) increased arterial pressure and peripheral resistance. Ganglionic blockade (25 mg/kg iv) significantly reduced the increase in resistance in the mesentery and kidney in intact and spinal-sectioned rats. Ganglionic blockade significantly decreased hindquarter resistance in intact rats but not in spinal-sectioned rats. Prazosin (200 micrograms/kg iv) significantly reduced the increased hindquarter resistance. We concluded that NO suppresses sympathetic vasoconstriction in the mesentery and kidney at the spinal level, whereas hindquarter tone is mediated at supraspinal and synaptic levels.  (+info)

Differential vascular alpha1-adrenoceptor antagonism by tamsulosin and terazosin. (7/1153)

AIMS: In patients with lower urinary tract symptoms suggestive of benign prostatic obstruction the alpha1-adrenoceptor antagonist terazosin lowers blood pressure whereas only very small if any alterations were reported with the alpha1-adrenoceptor antagonist tamsulosin. Therefore, we have compared the vascular alpha1-adrenoceptor antagonism of tamsulosin and terazosin directly. METHODS: Ten healthy subjects were investigated in a randomized, single-blind, three-way cross-over design and received a single dose of 0.4 mg tamsulosin, 5 mg terazosin or placebo on 3 study days at least 1 week apart. Before and 1, 3, 5, 7, 10 and 23.5 h after drug intake, alterations of diastolic blood pressure and other haemodynamic parameters in response to a graded infusion of the alpha1-adrenoceptor agonist phenylephrine were determined non-invasively. RESULTS: At most time points tamsulosin inhibited phenylephrine-induced diastolic blood pressure elevations significantly less than terazosin (5 h time point: median difference in inhibition 35%, 95% CI: 18.7-50.3%). On the other hand, phenylephrine-induced changes of cardiac output, heart rate and stroke volume were similar during both active treatments. CONCLUSIONS: In doses equi-effective for treatment of lower urinary tract symptoms tamsulosin causes less inhibition of vasoconstriction than terazosin.  (+info)

Characterization of alpha1-adrenoceptor subtypes mediating vasoconstriction in human umbilical vein. (8/1153)

1. The present study attempted to characterize pharmacologically the subtypes of alpha-adrenoceptors mediating contractions in human umbilical vein (HUV). 2. HUV rings were mounted in isolated organ baths and cumulative concentration-response curves were constructed for the alpha-adrenoceptor agonists phenylephrine and adrenaline. Adrenaline was more potent than phenylephrine (pD2=7.29 and 6.04 respectively). 3. Isoproterenol exhibited no agonism on KCl pre-contracted HUV rings. Propranolol (1 microM) and rauwolscine (0.1 microM) did not affect the concentration-response curves to adrenaline. These results demonstrate the lack of involvement of functional beta-or alpha2-adrenoceptors in adrenaline-induced vasoconstriction. 4. The non subtype selective alpha1-adrenoceptor antagonist prazosin was evaluated on phenylephrine and adrenaline concentration-response curves. The effects of the competitive alpha1A and alpha1D-adrenoceptor antagonists, 5-methyl urapidil and BMY 7378 and the irreversible alpha1B selective compound chloroethylclonidine (CEC) were also evaluated on adrenaline concentration-response curves. 5. The potencies of prazosin against responses mediated by adrenaline (pA2= 10.87) and phenylephrine (pA2= 10.70) indicate the involvement of prazosin-sensitive functional alpha1-adrenoceptor subtype in vasoconstriction of the HUV. 6. The potencies of 5-methyl urapidil (pA2 = 6.70) and BMY 7378 (pA2= 7.34) were not consistent with the activation of an alpha1A- or alpha1D-adrenoceptor population. 7. Exposure to a relatively low CEC concentration (3 microM) abolished the maximum response to adrenaline suggesting that this response was mediated by an alpha1B-adrenoceptor subtype. 8. We conclude that HUV express a prazosin-sensitive functional alpha1-adrenoceptor resembling the alpha1B-subtype according with the low pA2 values for both 5-methyl urapidil and BMY 7378 and the high sensitivity to CEC.  (+info)

Medical Definition of Scorpion Stings:

Scorpion stings are defined as the injury caused by the venomous sting of a scorpion. The venom contains a variety of compounds, including peptides, proteins, and enzymes, which can cause necrosis, inflammation, and pain. Scorpion stings can affect various parts of the body, including the skin, muscles, and organs.

Causes of Scorpion Stings:

Scorpion stings are caused by the venomous spines on the scorpion's tail. When the scorpion stings, it uses its tail to pierce the skin and inject the venom into the body. The venom can cause a range of symptoms, depending on the type of scorpion and the severity of the sting. Some common causes of scorpion stings include:

1. Scorpion bites: When a scorpion bites, it injects its venom into the body through its fangs.
2. Accidental contact: Scorpions may sting when they are disturbed or threatened, such as when someone accidentally steps on them or touches them.
3. Medical procedures: In some cases, scorpion stings may be intentionally administered as part of medical procedures, such as in the treatment of certain respiratory conditions.

Symptoms of Scorpion Stings:

The symptoms of scorpion stings can vary depending on the type of scorpion and the severity of the sting. Some common symptoms include:

1. Pain: Scorpion stings can cause severe pain, which may be felt locally at the site of the sting or more generally throughout the body.
2. Swelling: The area around the sting may become swollen and inflamed.
3. Redness: The skin around the sting may turn red and warm to the touch.
4. Itching: Some people may experience itching or a burning sensation at the site of the sting.
5. Blisters: Scorpion venom can cause blisters to form on the skin.
6. Numbness: In some cases, scorpion venom may cause numbness or tingling sensations in the face, arms, or legs.
7. Breathing difficulties: Scorpion venom can cause breathing difficulties, especially in children and people with pre-existing respiratory conditions.
8. Cardiac problems: In severe cases, scorpion venom can cause cardiac problems, such as abnormal heart rhythms or even heart failure.
9. Neurological symptoms: Some scorpion venoms can cause neurological symptoms, such as headaches, dizziness, and confusion.
10. Seizures: In rare cases, scorpion stings may cause seizures.

Treatment of Scorpion Sting
---------------------------

If you suspect that you or someone else has been stung by a scorpion, seek medical attention immediately. Here are some general treatment guidelines:

1. Remain calm: Try to remain as calm as possible and do not panic.
2. Remove the stinger: Gently remove the stinger from the skin using tweezers or a credit card. Avoid squeezing the stinger, as this can release more venom.
3. Clean the wound: Wash the wound with soap and water to prevent infection.
4. Apply ice: Apply an ice pack or cold compress to reduce swelling and pain.
5. Elevate the affected area: Elevate the limb or area where the sting occurred to reduce swelling.
6. Take antihistamines: Antihistamines, such as Benadryl, can help reduce itching and inflammation.
7. Use pain relief medication: Over-the-counter pain relief medication, such as acetaminophen or ibuprofen, can help relieve pain and discomfort.
8. Monitor for signs of infection: Monitor the wound for signs of infection, such as redness, swelling, increased pain, or pus. If you notice any of these symptoms, seek medical attention immediately.
9. Seek medical attention: If you experience any of the following symptoms, seek medical attention immediately:
* Difficulty breathing
* Rapid heartbeat
* Nausea and vomiting
* Abdominal pain
* Fever
* Confusion or disorientation

It is important to note that some scorpion stings can cause severe reactions, and in rare cases, can be fatal. If you suspect that you or someone else has been stung by a dangerous scorpion, do not hesitate to seek medical attention immediately.

"Prazosin". "Prazosin , Ligand page , IUPHAR/BPS Guide to PHARMACOLOGY". "Prazosin: Clinical data". IUPHAR. International Union ... Prazosin has an onset of action of 30 to 90 minutes, the elimination half-life of prazosin is 2 to 3 hours, and its duration of ... Prazosin has been shown to prevent death in animal models of cytokine storm. As a repurposed drug, prazosin is being ... A very rare side effect of prazosin is priapism. One phenomenon associated with prazosin is known as the "first dose response ...
First selective alpha-1 blocker that was approved to treat hypertension was prazosin. Prazosin was synthesized in 1974 when ... As of 2018, prazosin is the only alpha-1 blocker known to act as an inverse agonist at all alpha-1 adrenergic receptor subtypes ... Prazosin is commonly used as an anti-hypertensive, but because alpha-1 adrenergic activity has been connected to fear and ... Prazosin has been established as an effective and safe centrally active alpha-1 adrenergic receptor antagonist. It can be used ...
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Prazosin is an α1-blocker that acts as an inverse agonist at alpha-1 adrenergic receptors. Raskind and colleagues studied the ... "Prazosin: Biological activity". IUPHAR. International Union of Basic and Clinical Pharmacology. Retrieved 3 June 2016. Murray A ... Patients who were taking prazosin had a robust improvement in overall sleep quality (effect size, 1.6) and recurrent ... February 2003). "Reduction of Nightmares and Other PTSD Symptoms in Combat Veterans by Prazosin: A Placebo-Controlled Study". ...
"Prazosin-Related Compounds. Effect of Transforming the Piperazinylquinazoline Moiety into an Aminomethyltetrahydroacridine ...
Elsevier Saunergic blockers such as prazosin can be used to control Raynaud's vasospasms under supervision of a health care ... Sympatholytic agents, such as the alpha-adrenergic blocker prazosin, may provide temporary relief to secondary Raynaud's ... Waldo R (March 1979). "Prazosin relieves Raynaud's vasospasm". JAMA. 241 (10): 1037. doi:10.1001/jama.241.10.1037. PMID 762741 ... "Prazosin for Raynaud's phenomenon in progressive systemic sclerosis". Cochrane Database of Systematic Reviews (2): CD000956. ...
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The alpha blocker prazosin (Minipress) is most notorious for producing a first dose phenomenon. Other drugs of the same family ... For this reason, treatment with prazosin (Minipress) should always be initiated with a low dose and should be taken at bedtime ... "Minipress (Prazosin HCl) drug warnings and precautions - prescription drugs and medications at RxList". Archived from the ... First pass effect Graham RM, Thornell IR, Gain JM, Bagnoli C, Oates HF, Stokes GS (1976). "Prazosin: the first-dose phenomenon ...
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Prazosin Ketanserin David J. Triggle (1996). Dictionary of Pharmacological Agents. Boca Raton: Chapman & Hall/CRC. ISBN 0-412- ...
Adverse effects of prazosin to treat PTSD nightmares include dizziness, First Dose Effect (a sudden loss of consciousness), ... Green, Ben (2014). "Prazosin in the Treatment of PTSD". Journal of Psychiatric Practice. 20 (4): 253-259. doi:10.1097/01.pra. ... Prazosin, doxazosin, and terazosin have been particularly useful for patients with BPH, especially in patients with ... High doses of the α1 blocker, prazosin, have been efficacious in treating patients with PTSD induced nightmares due to its ...
... prazosin, propranolol, guanfacine, clonidine, quetiapine, olanzapine, valproate, gabapentin). Prazosin, an alpha-1 adrenergic ... Singh B, Hughes AJ, Mehta G, Erwin PJ, Parsaik AK (July 2016). "Efficacy of Prazosin in Posttraumatic Stress Disorder: A ... Green B (July 2014). "Prazosin in the treatment of PTSD". Journal of Psychiatric Practice. 20 (4): 253-9. doi:10.1097/01.pra. ...
A comparison of prazosin and moxisylyte". J. Auton. Nerv. Syst. 79 (2-3): 191-5. doi:10.1016/S0165-1838(99)00105-8. PMID ...
Minipress (Prazosin) - atypical psychotropic used to treat PTSD. Naltrexone (ReVia) - an opioid antagonist primarily used in ...
Usually, the drug Prazosin is recommended for H. tamulus stings. The drug can reduce the increasing blood pressure. Tamapin ... prazosin in the management of severe Mesobuthus tamulus (Indian red scorpion) envenoming at rural settings" (PDF). Journal of ... Scorpion antivenom has little effect in clinical treatment but application of prazosin reduces the mortality rate to less than ...
Kjaergaard N, Kjaergaard B, Lauritsen JG (June 1988). "Prazosin, an adrenergic blocking agent inadequate as male contraceptive ...
Koola, M. M.; Varghese, S. P.; Fawcett, J. A. (2013). "High-dose prazosin for the treatment of post-traumatic stress disorder ... The Alpha-1 agonist prazosin could be effective for PTSD. The Alpha-2 agonists clonidine and guanfacine have demonstrated both ...
Kjaergaard N, Kjaergaard B, Lauritsen JG; Kjaergaard; Lauritsen (June 1988). "Prazosin, an adrenergic blocking agent inadequate ...
Prazosin (Minipress) for nightmares: prazosin is approved for the use of hypertension. A 2012 systematic review showed a small ... Other non-FDA-approved uses for prazosin include the treatment of Raynaud's disease and poisoning due to scorpion venom. ...
This characteristic immobility could be counteracted by the pre-administration of prazosin. Subsequent experiments using the ... prazosin (standard α1 ligand); against [3H]-yohimbine (standard α2 ligand), l-synephrine showed a pIC50 = 5.01, and d- ... with prazosin being the more potent antagonist (pA2 = 9.38, vs pA2 = 8.23 for ketanserin). Synephrine constrictions were also ... This constriction was found to be competitively antagonized by prazosin (a standard α1 antagonist) and ketanserin, ...
An effective medication to help alleviate nightmares associated with PTSD is Prazosin. International Society for Neurochemistry ...
The most efficient is an alpha-blocker, Prazosin, which reduces tone during sleep by blocking noradrenergic receptors. Prazosin ... Medications like prazosin are sometimes used to treat nightmares in people with PTSD. Therapy usually helps to deal with the ... However, only few studies considered the effect of Prazosin in idiopathic nightmares. Benzodiazepines are also often used to ... Reduction of Nightmares and Other PTSD Symptoms in Combat Veterans by Prazosin: A Placebo-Controlled Study, American Journal of ...
... and prazosin. Sublingual nifedipine is not recommended in hypertensive urgencies. This is because nifedipine can cause rapid ...
Prazosin, an alpha-adrenoceptor antagonist, is also often prescribed, particularly for sleep-related symptoms. Early studies ... Reist C, Streja E, Tang CC, Shapiro B, Mintz J, Hollifield M (August 2021). "Prazosin for treatment of post-traumatic stress ... though a recent large trial did not show a statistically significant difference between prazosin and placebo. Antipsychotic ...
... prazosin, nifedipine, nitroprusside, and electrical stimulation". Neurourology and Urodynamics. 14 (2): 153-68. doi:10.1002/nau ...
1997). "Effects of acepromazine maleate, isoxsuprine hydrochloride and prazosin hydrochloride on laminar blood flow in healthy ...
Patients with hypertension on admission are given a single dose of 5 mg sublingual nifedipine and oral prazosin. The blood ... oral prazosin, and oxygen by mask. Galvez, A; Gimenez-Gallego, G; Reuben, JP; Roy-Contancin, L; Feigenbaum, P; Kaczorowski, GJ ...
... prazosin binding". Molecular Pharmacology. 29 (4): 321-30. PMID 3010073. Melchiorre C, Bolognesi ML, Budriesi R, Chiarini A, ...
To relax patients and allow for better sleep, Prazosin can be given to patients, which regulates their sympathetic response. ...
Prazosin hydrochloride 1 mg. White. 431. 59762-5310-1. 90s. Prazosin hydrochloride 2 mg. Pink and White. 437. 59762-5320-1. ... Prazosin hydrochloride has been shown to be excreted in small amounts in human milk. Caution should be exercised when prazosin ... Prazosin hydrochloride capsules are contraindicated in patients with known sensitivity to quinazolines, prazosin, or any of the ... The exact mechanism of the hypotensive action of prazosin is unknown. Prazosin causes a decrease in total peripheral resistance ...
Prazosin: learn about side effects, dosage, special precautions, and more on MedlinePlus ... Prazosin controls high blood pressure but does not cure it. Continue to take prazosin even if you feel well. Do not stop taking ... Prazosin is used alone or in combination with other medications to treat high blood pressure. Prazosin is in a class of ... Before taking prazosin,. *tell your doctor and pharmacist if you are allergic to prazosin, alfuzosin (Uroxatral), doxazosin ( ...
Learn about drug interactions between prazosin oral and yohimbe bark oral and use the RxList drug interaction checker to check ... Drug interactions with prazosin oral and yohimbe bark oral. home drug interactions checker , prazosin oral and yohimbe bark ... All generic drug interactions for prazosin oral (lists will include brand and generic names): ...
In reply to Re: Adding Parnate and prazosin. sigismund, posted by SLS on January 18, 2012, at 7:17:29 ... Re: Adding Parnate and prazosin.. Posted by creepy on January 26, 2012, at 1:42:11 ...
Prazosin Prazosin is used alone or in combination with other medications to treat high blood pressure. Prazosin is in a class ... with this combination.Talk with your health provider.Prazosin (Minipress)Quercetin might increase levels of prazosin. Taking ... Lopressor) Nifedipine (Adalat, Procardia) Phenoxybenzamine (Dibenzyline) Phentolamine (Regitine) Prazosin (Minipress) ... of medications called alpha- ... Prazosin comes as a capsule to take by mouth. It usually is taken two or three times ... ...
Prazosin is associated with a low rate of transient serum aminotransferase elevations and has not been clearly linked to ... Prazosin is a nonselective alpha-adrenergic antagonist (alpha-blocker) used in the therapy of hypertension. ... Prazosin is a nonselective alpha-adrenergic antagonist (alpha-blocker) used in the therapy of hypertension. Prazosin is ... Prazosin No authors listed In: LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. Bethesda ( ...
Prazosin is associated with a low rate of transient serum aminotransferase elevations and has not been clearly linked to ... Prazosin is a nonselective alpha-adrenergic antagonist (alpha-blocker) used in the therapy of hypertension. ... Prazosin is a nonselective alpha-adrenergic antagonist (alpha-blocker) used in the therapy of hypertension. Prazosin is ... Prazosin No authors listed In: LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. Bethesda ( ...
The average maintenance dose of prazosin was 14.8 mg, compared with 16.4 mg in the placebo group; 187 male study participants ... On average, patients in the prazosin group had significantly greater decreases in blood pressure, compared with the placebo ... The alpha-1 adrenergic receptor prazosin failed to improve recurring nightmares or sleep quality compared with placebo in ... the researchers randomized 152 veterans with sleep problems and PTSD to prazosin and 152 to a placebo. The participants were ...
Prazosin is an alpha blocker. It decreases arterial tone by allowing peripheral postsynaptic blockade. ...
Prazosin works by blocking alpha receptors in the body, relaxing the smooth muscles around blood vessels and lowering blood ... What is prazosin used for?. Prazosin can be used to manage hypertension or benign prostatic hyperplasia (BPH). ... Prazosin is unique because it has a very short half life and half of the drug is excreted from your body within 3 hours of ... Prazosin also has an effect on other alpha-receptors in the body, such as those in the bladder. This can lead to side effects, ...
Prazosin is an alpha-blocker that blocks a chemical in the body, causing blood vessels and the muscles around the urethra to ... Prazosin is in a group of drugs called alpha-adrenergic (AL-fa ad-ren-ER-jik) blockers. Prazosin relaxes your veins and ... Prazosin is used to treat hypertension (high blood pressure).. Prazosin may also be used for other purposes not listed in this ... Prazosin can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you ...
SENTENCE MITIGATION: PERSONAL NARRATIVE , PRESENTENCE INTERVIEW PREP. , ALLOCUTION , REENTRY PLANNING , RDAP , MEDICAL / MENTAL HEALTHCARE , MEDICATION AVAILABILITY , BOP PLACEMENT. ...
Prazosin is an alpha-blocker that blocks a chemical in the body, causing blood vessels and the muscles around the urethra to ... Prazosin is in a group of drugs called alpha-adrenergic (AL-fa ad-ren-ER-jik) blockers. Prazosin relaxes your veins and ... Prazosin is used to treat hypertension (high blood pressure).. Prazosin may also be used for other purposes not listed in this ... Prazosin can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you ...
... as well as a pulse Prazosin drug for blood pressure medication to keep the body to relax the blood Prazosin drug for blood ... what is Prazosin drug for blood pressure the medical term for white coat hypertension, however, as well as something to start ... This has been shown to be bigger to bind the daily care of the patients in the top of Prazosin drug for blood pressure the ... When you are working out the same time, Prazosin drug for blood pressure you have an instance, it can a local of any side ...
Prazosin. Heartburn, indigestion, sour stomach. *Axid®. Nizatidine. Rapid heartbeat; increased alcohol effect; sudden changes ...
Prazosin (Minipress). *Alfuzosin (Uroxatral). *Silodosin (Rapaflo). *Tamsulosin (Jalyn - combination of dutasteride and ...
Our goal was to have 10 in each arm; 10 in the Prazosin add-on and 10 in the placebo add-on, but out of those 20 two ... And we are first going to talk about Prazosin.. This study was done at the Medical College of Georgia, and I want to recognize ... Again, without the control group, if we only looked at Prazosin for a period of a number of weeks, you might be led to think ... Patients came to us already on stable doses of SSRIs or mood stabilizers, and then we added on either placebo or Prazosin at ...
Prazosin for Treating Agitation Trial. Enrollment to be announced. CSF Pharmacodynamic Trial ...
Prazosin. Heartburn, indigestion, sour stomach. *Axid®. Nizatidine. Rapid heartbeat; increased alcohol effect; sudden changes ...
Prazosin Hydrochloride. Azep. Azelastine Hydrochloride. Bactiflox. Ciprofloxacin Hydrochloride. Benzamycin. Benzoyl Peroxide; ...
Prazosin: (Moderate) razosin is well-known to produce a first-dose phenomenon. Some patients develop significant hypotension ... Concomitant administration of prazosin with other antihypertensive agents is not prohibited, however. This can be ... The first dose response (acute postural hypotension) of prazosin may be exaggerated in patients who are receiving beta- ... prazosin, reserpine, or other antihypertensive agents. Diethylpropion: (Moderate) Diethylpropion has vasopressor effects and ...
... prazosin (Minipress), terazosin (Hytrin), tamsulosin (Flomax), and alfuzosin (Uroxatral); angiotensin-converting enzyme (ACE) ...
Prazosin Generic * Prazotec Brand * Prazotec Injection Brand * Pre NAN Brand * Preabor Brand ...
Abstract: [3H]-Prazosin binding was characterized in cortical and spinal membranes from Fischer 344N and Sprague-Dawley rats. ... These data indicate that high affinity [3H]-prazosin binding in the homogenates of tissue from the CNS is affected critically ... Title: Buffer effects on high affinity [3H]-prazosin binding in brain and spinal cord. ... MeSH Terms: Animals; Brain/drug effects; Brain/metabolism*; HEPES/pharmacology*; Male; Piperazines/pharmacology*; Prazosin/ ...
Prazosin Hydrochloride. FDA approved. FDA approved. 296961. Amifostine. RP. FDA approved. FDA approved. ...
alpha-1 blockers (e.g., doxazosin, prazosin, tamsulosin). *amiodarone *amifostine. *amphetamines (e.g., dextroamphetamine, ...
  • tell your doctor and pharmacist if you are allergic to prazosin, alfuzosin (Uroxatral), doxazosin (Cardura), terazosin, any other medications, or any ingredients in prazosin capsules. (medlineplus.gov)
  • You should not use this medication if you are allergic to prazosin or similar medicines such as alfuzosin (Uroxatral), doxazosin (Cardura), silodosin (Rapaflo), tamsulosin (Flomax), or terazosin (Hytrin). (erectiledysfunctionl.com)
  • Do not stop taking prazosin without talking to your doctor. (medlineplus.gov)
  • Prazosin is in a class of medications called alpha-blockers. (medlineplus.gov)
  • you should know that prazosin may cause dizziness, lightheadedness, and fainting when you get up too quickly from a lying position. (medlineplus.gov)
  • Prazosin lowers blood pressure and may cause dizziness or fainting, especially when you first start taking it or whenever your dose is changed. (erectiledysfunctionl.com)
  • The alpha-1 adrenergic receptor prazosin failed to improve recurring nightmares or sleep quality compared with placebo in veterans with PTSD in a 26-week randomized trial of 304 adult veterans. (mdedge.com)
  • In several previous randomized trials lasting fewer than 15 weeks, veterans with PTSD and recurring nightmares who received prazosin showed benefits, including improved sleep quality and PTSD symptoms, compared with placebo patients, wrote Murray A. Raskind, MD , of the Department of Veterans Affairs Puget Sound Health Care System, Seattle, and his colleagues. (mdedge.com)
  • In a study published in the New England Journal of Medicine , the researchers randomized 152 veterans with sleep problems and PTSD to prazosin and 152 to a placebo. (mdedge.com)
  • 187 male study participants reached the maximum dose of 20 mg/day (54% of the prazosin group and 70% of the placebo group). (mdedge.com)
  • On average, patients in the prazosin group had significantly greater decreases in blood pressure, compared with the placebo group. (mdedge.com)
  • Your doctor will probably start you on a low dose of prazosin and gradually increase your dose. (medlineplus.gov)
  • Do not drive a car, operate machinery, or perform dangerous tasks for 24 hours after the first time you take prazosin or after your dose is increased. (medlineplus.gov)
  • This is more common when you first start taking prazosin, when your dose is increased, or when another blood pressure medication is added to your treatment. (medlineplus.gov)
  • However, prazosin, a ML2 receptor antagonist in the low dose (0.5 mg/kg) significantly attenuated but in higher dose (1 mg/kg) enhanced the analgesic effect of melatonin. (who.int)
  • Responses were inhibited by the predominantly MT2-selective antagonist luzindole but not by prazosin, acting at MT3 receptors. (jci.org)
  • If you become pregnant while taking prazosin, call your doctor. (medlineplus.gov)
  • Prazosin is used alone or in combination with other medications to treat high blood pressure. (medlineplus.gov)
  • talk to your doctor about the risks and benefits of taking prazosin if you are 65 years of age or older. (medlineplus.gov)
  • if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking prazosin. (medlineplus.gov)
  • If you need to have eye surgery at any time during or after your treatment, be sure to tell your doctor that you are taking or have taken prazosin. (medlineplus.gov)
  • ask your doctor about the safe use of alcoholic beverages while you are taking prazosin. (medlineplus.gov)
  • Prazosin is available in capsules of 1, 2 and 5 mg generically and under the trade name Minipress. (nih.gov)
  • Recent animal studies, however, have suggested that the vasodilator effect of prazosin is also related to blockade of postsynaptic alpha - adrenoceptors. (nih.gov)
  • The results of dog forelimb experiments demonstrate that the peripheral vasodilator effect of prazosin is confined mainly to the level of the resistance vessels (arterioles). (nih.gov)
  • bremelanotide will decrease the level or effect of prazosin by Other (see comment). (medscape.com)
  • Prazosin hydrochloride capsules, USP a quinazoline derivative, is the first of a new chemical class of antihypertensives. (nih.gov)
  • Prazosin hydrochloride capsules are indicated for the treatment of hypertension, to lower blood pressure. (nih.gov)
  • tell your doctor and pharmacist if you are allergic to prazosin, alfuzosin (Uroxatral), doxazosin (Cardura), terazosin, any other medications, or any ingredients in prazosin capsules. (medlineplus.gov)
  • Unlike conventional alpha - blockers, the antihypertensive action of prazosin is usually not accompanied by a reflex tachycardia. (nih.gov)
  • In this study, Freis's group found no significant differences in the overall effectiveness between antihypertensive treatments with prazosin (an alpha-blocker that reduces the nerve impulses that constricts blood vessels) and hydralazine (a vasodilator that acts directly on blood vessels to relax them) in patients also receiving the diuretic hydrochlorothiazide. (nih.gov)
  • Animal studies indicate that prazosin hydrochloride is extensively metabolized, primarily by demethylation and conjugation, and excreted mainly via bile and feces. (nih.gov)
  • Prazosin is extensively metabolized by the liver and generation of a mildly toxic intermediate is a possible explanation. (nih.gov)
  • Prazosin comes as a capsule to take by mouth. (medlineplus.gov)
  • Each capsule, for oral use, contains prazosin hydrochloride, USP equivalent (as the polyhydrate) to 1 mg, 2 mg or 5 mg of prazosin. (nih.gov)
  • Mean daily doses of prazosin in the studies and case reports ranged from 1 mg/day to 13 mg/day. (medscape.com)
  • Prazosin is usually started at a dose of 1 mg two or three times daily, with increase in the dose based upon tolerance and clinical response to an average of 5 to 20 mg daily in divided doses. (nih.gov)
  • Prazosin causes a decrease in total peripheral resistance and was originally thought to have a direct relaxant action on vascular smooth muscle. (nih.gov)
  • Prazosin is an alpha-adrenergic blocker originally used to treat hypertension. (medscape.com)
  • Prazosin is a nonselective alpha-adrenergic antagonist (alpha-blocker) used in the therapy of hypertension. (nih.gov)
  • Prazosin (pray' zoe sin) was the first alpha-adrenergic antagonist to be approved for use in the United States and is still widely used for therapy of hypertension. (nih.gov)
  • Prazosin was approved for use in the United States in 1976 and is still used for treatment of hypertension, although rarely as a first line agent and usually in combination with other antihypertensives. (nih.gov)
  • The effects of oral administration of 2 mg prazosin on several metabolic and endocrine variables were evaluated in 12 patients with hypertension (6 with normal and 6 with abnormal glucose tolerance). (nih.gov)
  • In clinical studies to date, prazosin hydrochloride has not increased plasma renin activity. (nih.gov)
  • prazosin and acebutolol both increase anti-hypertensive channel blocking. (medscape.com)
  • Alcohol can make the side effects from prazosin worse. (medlineplus.gov)
  • The reason we think it works in the setting of nightmares is that prazosin crosses the blood-brain barrier, so it gets into the brain and kind of dampens the norepinephrine effects, which we think contribute to nightmares," he said. (medscape.com)
  • sildenafil increases effects of prazosin by pharmacodynamic synergism. (medscape.com)
  • aceclofenac decreases effects of prazosin by pharmacodynamic antagonism. (medscape.com)
  • aspirin decreases effects of prazosin by pharmacodynamic antagonism. (medscape.com)
  • Metabolic effects of chronic prazosin treatment. (nih.gov)
  • Buffer effects on high affinity [3H]-prazosin binding in brain and spinal cord. (nih.gov)
  • Prazosin is used alone or in combination with other medications to treat high blood pressure. (medlineplus.gov)
  • Prazosin controls high blood pressure but does not cure it. (medlineplus.gov)
  • Effect of alpha-1-blockade by prazosin on blood sugar, insulin and glucagon levels in normals and non-insulin dependent diabetics. (nih.gov)
  • Dr. Kung explained that his team reviewed all 12 studies of prazosin published before January 9, 2012, which involved 276 patients, and concluded that the studies are of fair to good quality. (medscape.com)
  • The researchers did not find any studies evaluating prazosin for nightmares not associated with PTSD or its related conditions. (medscape.com)
  • Prazosin is in a class of medications called alpha-blockers. (medlineplus.gov)
  • Prazosin inhibits alpha-adrenergic receptors present on smooth muscle in arterioles (so-called alpha-1b adrenergic receptors) as well as in those in the bladder neck and prostate (alpha-1a adrenergic receptors). (nih.gov)
  • Prazosin has not been fully evaluated or approved for therapy of benign prostatic hypertrophy (as have other alpha-1 adrenergic antagonists). (nih.gov)
  • References on the safety and potential hepatotoxicity of prazosin and other alpha-blockers are given in the Overview on Alpha-1 Adrenergic Receptor Antagonists. (nih.gov)
  • The first time taking prazosin, you should take it before you go to bed. (medlineplus.gov)
  • If you need to have eye surgery at any time during or after your treatment, be sure to tell your doctor that you are taking or have taken prazosin. (medlineplus.gov)
  • Brotherhood of Steel which Prazosin Cialis remain should online in his or spending a lot of time effort or money. (paula-reed.com)
  • Prazosin hydrochloride, USP a quinazoline derivative, is the first of a new chemical class of antihypertensives. (nih.gov)
  • Dr. Raskind explained that when a patient with PTSD is treated with prazosin, as the trauma nightmares go away, normal dreams return. (medscape.com)
  • viagra bewertung to bankrupt businessmen the drawback that it 6 985) as in there is a legitimate campaign to bring Scotland use with Prazosin Cialis 50 return" the moment ejaculation. (paula-reed.com)
  • Prazosin improves urine flow rates by relaxing smooth muscle. (medscape.com)
  • March 12, 2012 (Prague, Czech Republic) - A systematic review of the literature supports the use of prazosin to treat nightmares related to posttraumatic stress disorder (PTSD). (medscape.com)
  • No instances of clinically apparent acute liver injury due to prazosin have been published in the literature, but reports of cholestatic hepatitis have been received by the sponsor. (nih.gov)
  • Prazosin is also available in a fixed combination with polythiazide (Minizide). (nih.gov)