An anthelmintic used in most schistosome and many cestode infestations.
Agents destructive to parasitic worms. They are used therapeutically in the treatment of HELMINTHIASIS in man and animal.
Agents that act systemically to kill adult schistosomes.
Determination of parasite eggs in feces.
Schistosomiasis caused by Schistosoma mansoni. It is endemic in Africa, the Middle East, South America, and the Caribbean and affects mainly the bowel, spleen, and liver.
A species of trematode blood flukes of the family Schistosomatidae which occurs at different stages in development in veins of the pulmonary and hepatic system and finally the bladder lumen. This parasite causes urinary schistosomiasis.
A human disease caused by the infection of parasitic worms SCHISTOSOMA HAEMATOBIUM. It is endemic in AFRICA and parts of the MIDDLE EAST. Tissue damages most often occur in the URINARY TRACT, specifically the URINARY BLADDER.
A species of trematode blood flukes of the family Schistosomatidae. It is common in the Nile delta. The intermediate host is the planorbid snail. This parasite causes schistosomiasis mansoni and intestinal bilharziasis.
Infection of the biliary passages with CLONORCHIS SINENSIS, also called Opisthorchis sinensis. It may lead to inflammation of the biliary tract, proliferation of biliary epithelium, progressive portal fibrosis, and sometimes bile duct carcinoma. Extension to the liver may lead to fatty changes and cirrhosis. (From Dorland, 27th ed)
An anthelmintic with schistosomicidal activity against Schistosoma mansoni, but not against other Schistosoma spp. Oxamniquine causes worms to shift from the mesenteric veins to the liver where the male worms are retained; the female worms return to the mesentery, but can no longer release eggs. (From Martindale, The Extra Pharmacopoeia, 31st ed, p121)
Infection with flukes (trematodes) of the genus SCHISTOSOMA. Three species produce the most frequent clinical diseases: SCHISTOSOMA HAEMATOBIUM (endemic in Africa and the Middle East), SCHISTOSOMA MANSONI (in Egypt, northern and southern Africa, some West Indies islands, northern 2/3 of South America), and SCHISTOSOMA JAPONICUM (in Japan, China, the Philippines, Celebes, Thailand, Laos). S. mansoni is often seen in Puerto Ricans living in the United States.
A benzimidazole broad-spectrum anthelmintic structurally related to MEBENDAZOLE that is effective against many diseases. (From Martindale, The Extra Pharmacopoeia, 30th ed, p38)
Infections caused by infestation with worms of the class Trematoda.
A phylum of acoelomate, bilaterally symmetrical flatworms, without a definite anus. It includes three classes: Cestoda, Turbellaria, and Trematoda.
Schistosomiasis caused by Schistosoma japonicum. It is endemic in the Far East and affects the bowel, liver, and spleen.
A species of trematode blood flukes belonging to the family Schistosomatidae whose distribution is confined to areas of the Far East. The intermediate host is a snail. It occurs in man and other mammals.
A genus of trematode flukes belonging to the family Schistosomatidae. There are over a dozen species. These parasites are found in man and other mammals. Snails are the intermediate hosts.
Juvenile hormone analog and insect growth regulator used to control insects by disrupting metamorphosis. Has been effective in controlling mosquito larvae.
Drugs used to treat or prevent parasitic infections.
Infections with true tapeworms of the helminth subclass CESTODA.
A species of trematode flukes of the family Opisthorchidae. Many authorities consider this genus belonging to Opisthorchis. It is common in China and other Asiatic countries. Snails and fish are the intermediate hosts.
Agents used to treat tapeworm infestations in man or animals.
Infection with TREMATODA of the genus PARAGONIMUS.
A genus of tapeworm containing several species which occurs in the intestine of fish, birds, and mammals including man. Infection in humans is usually by eating uncooked fish. The larval stage is known as SPARGANUM.
A mixture of mostly avermectin H2B1a (RN 71827-03-7) with some avermectin H2B1b (RN 70209-81-3), which are macrolides from STREPTOMYCES avermitilis. It binds glutamate-gated chloride channel to cause increased permeability and hyperpolarization of nerve and muscle cells. It also interacts with other CHLORIDE CHANNELS. It is a broad spectrum antiparasitic that is active against microfilariae of ONCHOCERCA VOLVULUS but not the adult form.
Infection with tapeworms of the genus Diphyllobothrium.
A genus of lung flukes of the family Troglotrematidae infecting humans and animals. This genus consists of several species one of which is PARAGONIMUS WESTERMANI, a common lung fluke in humans.
A family of intestinal flukes of the class Trematoda which occurs in animals and man. Some of the genera are Heterophyes, Metagonimus, Cryptocotyle, Stellantchasmus, and Euryhelmis.
Infection with flukes of the genus Opisthorchis.
Immunoglobulins produced in a response to HELMINTH ANTIGENS.
An infection caused by the infestation of the larval form of tapeworms of the genus Echinococcus. The liver, lungs, and kidney are the most common areas of infestation.
Infection with CYSTICERCUS, the larval form of the various tapeworms of the genus Taenia (usually T. solium in man). In humans they penetrate the intestinal wall and invade subcutaneous tissue, brain, eye, muscle, heart, liver, lung, and peritoneum. Brain involvement results in NEUROCYSTICERCOSIS.
A subclass of segmented worms comprising the tapeworms.
Any part or derivative of a helminth that elicits an immune reaction. The most commonly seen helminth antigens are those of the schistosomes.
A genus of trematode liver flukes of the family Opisthorchidae. It consists of the following species: O. felineus, O. noverca (Amphimerus noverca), and O. viverrini. The intermediate hosts are snails, fish, and AMPHIBIANS.
Infection by flukes of the genus Echinostoma.
Excrement from the INTESTINES, containing unabsorbed solids, waste products, secretions, and BACTERIA of the DIGESTIVE SYSTEM.
Infections or infestations with parasitic organisms. The infestation may be experimental or veterinary.
Diseases of the domestic cat (Felis catus or F. domesticus). This term does not include diseases of the so-called big cats such as CHEETAHS; LIONS; tigers, cougars, panthers, leopards, and other Felidae for which the heading CARNIVORA is used.
Class of parasitic flukes consisting of three subclasses, Monogenea, Aspidogastrea, and Digenea. The digenetic trematodes are the only ones found in man. They are endoparasites and require two hosts to complete their life cycle.
A genus of large tapeworms.
Infections with nematodes of the genus TOXASCARIS.
A republic in southern Africa, east of ZAMBIA and BOTSWANA and west of MOZAMBIQUE. Its capital is Harare. It was formerly called Rhodesia and Southern Rhodesia.
An ascarid nematode found primarily in the small intestine of the larger Felidae as well as dogs and cats. It differs from TOXOCARA in that the larvae do not migrate through the lungs. It does occasionally produce visceral larva migrans (LARVA MIGRANS, VISCERAL) in man, although more rarely than does Toxocara.
A group of SESQUITERPENES and their analogs that contain a peroxide group (PEROXIDES) within an oxepin ring (OXEPINS).
Infection with tapeworms of the genus Taenia.
Infestation with parasitic worms of the helminth class.
A superfamily of nematodes of the order STRONGYLIDA. Characteristics include a fluid-filled outer layer of cuticle and a reduced mouth and bursa.
Infections of the INTESTINES with PARASITES, commonly involving PARASITIC WORMS. Infections with roundworms (NEMATODE INFECTIONS) and tapeworms (CESTODE INFECTIONS) are also known as HELMINTHIASIS.
A species of hydatid tapeworm (class CESTODA) in the family Taeniidae, whose adult form infects the DIGESTIVE TRACT of DOGS, other canines, and CATS. The larval form infects SHEEP; PIGS; HORSES; and may infect humans, where it migrates to various organs and forms permanent HYDATID CYSTS.
A republic in eastern Africa, south of SUDAN and west of KENYA. Its capital is Kampala.
Infection with tapeworms of the genus Hymenolepis.
A genus of intestinal flukes of the family Echinostomatidae which consists of many species. They occur in man and other vertebrates. The intermediate hosts are frequently mollusks.
SCHISTOSOMIASIS of the brain, spinal cord, or meninges caused by infections with trematodes of the genus SCHISTOSOMA (primarily SCHISTOSOMA JAPONICUM; SCHISTOSOMA MANSONI; and SCHISTOSOMA HAEMATOBIUM in humans). S. japonicum infections of the nervous system may cause an acute meningoencephalitis or a chronic encephalopathy. S. mansoni and S. haematobium nervous system infections are associated with acute transverse myelitis involving the lower portions of the spinal cord. (From Joynt, Clinical Neurology, 1998, Ch27, pp61-2)
Potentially toxic, but effective antischistosomal agent, it is a metabolite of LUCANTHONE.
A republic in western Africa, south of MALI and BURKINA FASO, bordered by GHANA on the east. Its administrative capital is Abidjan and Yamoussoukro has been the official capital since 1983. The country was formerly called Ivory Coast.
Species of tapeworm in the genus TAENIA, that infects swine. It is acquired by humans through the ingestion of cured or undercooked pork.

Double-blind placebo-controlled study of concurrent administration of albendazole and praziquantel in schoolchildren with schistosomiasis and geohelminths. (1/532)

A double-blind placebo-controlled study of the concurrent administration of albendazole and praziquantel was conducted in>1500 children with high prevalences of geohelminths and schistosomiasis. The study sites were in China and the Philippines, including 2 strains of Schistosoma japonicum, and 2 different regions of Kenya, 1 each with endemic Schistosoma mansoni or Schistosoma haematobium. Neither medication affected the cure rate of the other. There was no difference between the side effect rate from albendazole or the double placebo. Praziquantel-treated children had more nausea, abdominal pain, and headache but these side effects were statistically more common in children with schistosomiasis, suggesting a strong influence of dying parasites. The subjects were followed for 6 months for changes in infection status, growth parameters, hemoglobin, and schistosomiasis morbidity. In all 4 sites, a significant 6-month increase in serum hemoglobin was observed in children who received praziquantel, strongly supporting population-based mass treatment.  (+info)

Effect of mebendazole and praziquantel on glucosephosphate isomerase and glyceraldehydephosphate dehydrogenase in Echinococcus granulosus cyst wall harbored in mice. (2/532)

AIM: To study effects of antihydatid drugs on glucosephosphate isomerase (GPI) and glyceraldehydephosphate dehydrogenase (GAPDH) in Echinococcus granulosus cyst wall. METHODS: Mice infected with the parasite for 8-10 months were treated i.g. with mebendazole (Meb) or praziquantel (Pra). The activities of GPI and GAPDH in the cysts were measured by the formation of NADH or NADPH. RESULTS: GPI activity in the cyst wall was 197 +/- 103 U, while that of GAPDH was 25 +/- 13 U. When infected mice were treated i.g. with Meb 25-50 mg.kg-1.d-1 for 7-14 d, no apparent effect on the GAPDH activity in the cyst was found. In mice treated i.g. with praziquantel (Pra) 500 mg.kg-1.d-1 for 14 d, the GAPDH activity in the cyst wall was inhibited by 26.5%. As to GPI activity only the group treated i.g. with Meb 25 mg.kg-1.d-1 for 14 d showed 33.2% inhibition of the enzyme in the collapsed cyst wall. CONCLUSION: GPI and GAPDH are not the major targets attacked by the antihydatid drug.  (+info)

Resolution and resurgence of schistosoma haematobium-induced pathology after community-based chemotherapy in ghana, as detected by ultrasound. (3/532)

Community-based treatment is recommended for endemic populations with urinary schistosomiasis; however, the optimal target group for treatment and retreatment interval have not been established. Using ultrasound, this study identified subpopulations whose lesions were most likely to respond to treatment and characterized resurgence of pathology. Ultrasound examination of 1202 infected patients was followed by chemotherapy with praziquantel. A sample of 698 patients was followed for 18 months after treatment. Nearly all types of bladder pathologies resolved after treatment, regardless of patient's age or intensity of initial infection. However, many patients' upper urinary tract pathologies (62.5%) did not resolve. During the 18-month follow-up period, reappearance of severe bladder pathologies was rare, and <10% of persons had resurgence of mild bladder pathologies. For this population, retreatment is not needed annually but might be cost effective if given several years later. Confirmation from other areas is required before general policies can be formed.  (+info)

Seroepidemiology of schistosomiasis in Puerto Rico: evidence for vanishing endemicity. (4/532)

The current study summarizes our findings of anti-schistosome egg antibody by the circumoval precipitin test for two different populations in Puerto Rico. One group, exclusively males more than 40 years of age and from all municipalities on the island, was from the Veterans Administration Hospital for the period 1988-1997. The second group resided southeast of San Juan, around the municipality of Caguas and adjacent municipalities east of Caguas, was of both sexes and mostly until 1997 of undetermined ages for the period 1993-1997. Results reveal a yearly decrease in testing requests from the Veterans Administration Hospital from 148 in 1988 and 1989 with 16% positive to three in 1996 through 1998 with none positive. This decrease in testing requests was because of a decrease of suspicion of schistosomiasis in this group. The other patient population from the Caguas region showed a gradual but continuous decrease in seropositive individuals from 21% in 1993 to 12% in 1996, with precipitous decrease to 5% in 1997 and only 1% in 1998. Moreover, there were four patients from which at least two serum samples were obtained one or two years apart and tested. In each instance the more recently obtained sample had lower antibody reactions than the first as reflected in lower percentages of positive egg reactors. The fact that they were treated with praziquantel after the first testing also suggests that the infected population was being eliminated through chemotherapy. These combined results suggest the elimination of infections with Schistosoma mansoni in the traditionally high prevalence regions east of San Juan in the absence of any proactive control efforts in Puerto Rico. Because of the rapid urbanizing of Puerto Rico, the one identifiable control effort is economic development and well being.  (+info)

Cost of school-based drug treatment in Tanzania. The Partnership for Child Development. (5/532)

It has been argued that targeting delivery of anthelmintics to school-children by taking advantage of the existing education infrastructure and administrative system can be one of the most cost-effective approaches in minimizing the intensity of infections with both schistosomiasis and major intestinal nematodes in many developing countries. The study was conducted in January 1997, shortly after the completion of the drug intervention programme. This paper provides an analysis of the costs of providing age-targeted treatment of school-children for urinary schistosomiasis using praziquantel and for intestinal nematodes using albendazole as an integral part of the School Health Programme in Tanga Region, Tanzania. The analysis shows that the total financial cost of the intervention programme in 1996 prices was US$54 252.28 (exchange rate: TSH 573 = US$1). Of this amount, the cost of drugs constitutes 80.6%, while the delivery cost appears relatively low, representing just below 20%. Even when the opportunity cost of unpaid days of labour input is included, the cost of drugs still remains the highest cost component of the intervention (55.8%). In the current epidemiological and logistic setting of Tanzania, the financial cost per child treated using praziquantel, which involved prior screening at the school level, was US$0.79, while treatment using albendazole was as low as US$0.23, of which US$0.20 was drug purchase cost. It is concluded that the base cost of delivering a universal, standard, school-based health intervention such as albendazole can be as low as US$0.03 per child tested, but even a very slight increase in the complexity of delivery can have a very significant impact on the cost of intervention.  (+info)

Evidence for an improvement in cognitive function following treatment of Schistosoma japonicum infection in Chinese primary schoolchildren. (6/532)

A double-blind, placebo-controlled, treatment trial was conducted in Sichuan, China to investigate the unique and combined effects on the cognitive function (working memory) of children after treating geohelminth infections with albendazole and treating Schistosoma japonicum infection with praziquantel. One hundred eighty-one children 5-16 years of age participated. At baseline, the praziquantel and placebo groups were similar in all background characteristics. Three months after praziquantel treatment, there was a significant reduction in the prevalence and intensity of S. japonicum infection. There were significant age group by praziquantel treatment interaction effects in three of the five cognitive tests, Fluency, Picture Search, and Free Recall, with effects being strongest in the youngest children (5-7 years old). Exploratory analysis within the youngest children showed a significant positive main effect of treatment on Fluency (P < 0.001), after controlling for sex, anthropometric, and parasitic and iron status. There was also a treatment by height-for-age interaction (P = 0.03) and a treatment by iron status interaction (P = 0.024) on Fluency. There was a treatment by S. japonicum intensity interaction (P < 0.001) on Free Recall, but the main effect of treatment on Picture Search was not significant (P = 0.058). Younger children and those who are physically the most vulnerable are likely to benefit the most from the treatment of S. japonicum infection in terms of improved performance on tests of working memory.  (+info)

Relationships between several markers of extracellular matrix turn-over and ultrasonography in human Schistosomiasis mansoni. (7/532)

We measured the concentrations of several serum and urinary fibrosis markers, which are metabolites of extracellular matrix, in schistosomiasis patients to investigate their relationship with the ultrasonographic scoring system and with parasitologic data. This study was conducted in patients with various stages of the disease evaluated by ultrasonography (intestinal disease with no organ involvement, with minor hepatosplenic involvement and with severe disease) and in endemic controls. The level of hyaluronan, which were increased in infected patients compared with controls (P < 0.01), was the only fibrosis marker that correlated with the ultrasonographic score (P = 0.003) and is thus a potential serum marker of schistosomiasis-associated morbidity. Urinary free pyridinoline levels were lower (P < 0.001) in infected patients with fibrosis (score > or = 1) than in nonfibrotic patients. A two-year follow-up of the patients treated with praziquantel showed that type I collagen and hyaluronan decreased during the first year post-treatment, whereas free pyridinolines peaked after 12 months and decreased thereafter.  (+info)

Long-lasting sonographic and histopathological findings in cured clonorchiasis of rabbits. (8/532)

To ascertain residual sonographic and histopathological findings of clonorchiasis after treatment, the present study evaluated sonographic findings in rabbits which were infected with 500 metacercariae of C. sinensis every 6 months for 18 months after treatment with praziquantel. The sonographic findings were analyzed in terms of intrahepatic bile duct dilatation and periductal echogenicity, and histopathological findings were observed after the last sonographic examination. Compared with the sonographic findings before treatment, dilatation of the intrahepatic bile ducts became mild to some degree in four of the seven cases and increased periductal echogenicity resolved in four of them. The histopathological specimens after 18 months showed that periductal inflammation has almost resolved but moderate dilatation of the intrahepatic ducts and mucosal hyperplasia persisted. The periductal fibrosis minimally resolved. The long-lasting sonographic findings in cured clonorchiasis make sonography less specific.  (+info)

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In view of the known relationship between changes in the tegumental surface of schistosomes and the potency of antischistosomal drugs, the present work is done to study the effect of two oral drugs, namely Praziquantel and Ro-15 (5458), on the tegument of Schistosoma mansoni by scanning electron microscopy. The damage produced in the tegument of both male and female worms after treatment with the curative and subcurative doses of Praziquantel and Ro-15 (5458) are described. A pronounced deformation of the whole worms was detected after the treatment with a combined reduced dose of the two oral antibilharzial drugs. The potency of the new compound Ro-15 (5458) is encouraging and deserves further studies to be recommended as an antischistosomal drug, particularly in those cases which may show evidence of drug resistance to Praziquantel ...
Praziquantel (PZQ) efficacy and immune responses to schistosome antigens following cure were investigated in Schistosoma mansoni infected adult fishermen resident in Kisumu, Kenya with or without human immunodeficiency virus (HIV) co-infection. Schistosomiasis negative/HIV negative and schistosomiasis negative/HIV positive fishermen were used as controls. Proliferative responses to schistosome soluble egg antigen (SEA), soluble adult worm antigen preparation (SWAP), phytohaemagglutinin (PHA) and mycobacterium tuberculosis purified protein derivative (PPD) as well as leves of typical T helper-1 (TH-1) type, [gamma interferon (IFN-)] and T helper-2 (TH-2) type [Interleukin-4 (IL-4) and Interleukin-10 (IL-10)] cytokines were assayed at baseline, one month and four months post-treatment with Praziquantel. Indications of immunosuppression were determined by CD4+ counts and HIV testing by ELISA and Western blot. Cure success and reinfection rates were determined by longitudinal follow up of eggs ...
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Praziquantel is primarily used against parasites known as cestodes (tapeworms). Common Tapeworm of dogs & cats (Dipylidium caninum), is the usual target of praziquantel. Praziquantel is also effective against less common types of tapeworms and the more dangerous Mesocestoides species and Echinococcus species.
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We included 30 RCTs enrolling 8165 participants in this review. Twenty-four trials were conducted in children in sub-Saharan Africa, and 21 trials were over 20 years old. Many studies were assessed as being at unclear risk of bias due to inadequate descriptions of study methods.. Praziquantel On average, a single 40 mg/kg dose of praziquantel reduced the proportion of people still excreting eggs in their urine by around 60% compared to placebo at one to two months after treatment (treatment failure: RR 0.42, 95% CI 0.29 to 0.59, 864 participants, seven trials, high quality evidence). The proportion of people cured with praziquantel varied substantially between trials, from 22.5% to 83.3%, but was higher than 60% in five of the seven trials. At one to two months following praziquantel treatment at 40 mg/kg, the mean number of schistosome eggs in the urine was reduced by over 95% in five out of six trials (678 participants, six trials, high quality evidence).. Splitting praziquantel 40 mg/kg into ...
Abstract From June 1982 to May 1986 in a small village in Kwale, Kenya, we studied seasonal fluctuations in populations of Bulinus globosus, prevalence of Schistosoma haematobium infection in this snail, and effects of chemotherapy and piped water supply on infection rate of snails. In the perennially-flowing Pemba River, relatively small numbers of snails were collected; they were found only during the hot dry season (December to March). In a tributary stream, the Kadingo River, whose flow ceased at the end of both the cool and hot dry seasons, snail numbers peaked at the end of the cool dry season (October to November) and at the beginning of the hot dry season (January). Large numbers of infected snails were found in the Kadingo River from November to January (short rainy season and beginning of dry season). Selective mass chemotherapy with metrifonate and provision of piped water were begun in February and March 1984. These control measures achieved a significant reduction in the infection rate of
Bayer contacted WHO at an early stage of drug development and asked for advice and support for the further clinical development of praziquantel. According to Wegner (1981), A close and fruitful cooperation was established, which resulted in the setting up of well coordinated trial protocols. Case report sheets were standardized as far as possible for the first intercontinental multicentre trials in investigational phases IIA, IIB, and III. An overview of the literature about these first stages of clinical trials and conferences is given by Dollery (1991).. In this collaboration, clinical trials of tolerance to praziquantel and of its therapeutic effects against the three common species of schistosomes infecting man (S. haematobium, S. mansoni, and S. japonicum) were conducted jointly by the WHO Parasitic Diseases Programme, and the Medical Department in the Pharmaceutical Research Centre of Bayer, in Africa, Japan, the Philippines and South America (Wegner, 1981). The studies on S. haematobium ...
On 8 December, the European & Developing Countries Clinical Trials Partnership (EDCTP) and The Global Health Innovative Technology Fund (GHIT) announced that they will be co-funding the Phase III clinical study conducted by the Pediatric Praziquantel Consortium. This study aims to provide clinical data and support for registration of a new praziquantel (PZQ) tablet formulation to treat schistosomiasis in preschool-aged children in sub-Saharan Africa.. ...
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At the beginning of the 1970s, the search for effective tranquilizers with few side effects was being actively pursued in the pharmaceutical industry. Scientists at E. Merck considered the pyrazinoisoquinoline substance group a promising possibility, but found that relatively high doses had to be used in order to achieve an effect comparable to that of established tranquilizers. As a result, the compounds in this group were not pursued further at E. Merck; according to an agreement between the two firms, the compounds were passed on to Bayer for veterinary screening (Groll, 1984). Using a step-by-step procedure, the most effective substance, praziquantel, was chosen from a total of approximately 400 compounds. This substance was found to be an effective anthelminthic against a broad spectrum of parasitic trematodes and cestodes (Andrews et al., 1983). The drug was first developed for veterinary use and later tested for the treatment of helminthic infections in humans.. The therapeutic potential ...
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Technical summary of IVERQUANTEL Paste for HORSES - CALEDONIAN - ivermectin + praziquantel, macrocyclic lactone + isoquinoline, for the control of gastrointestinal roundworms, lungworms, tapeworms, and bots on horse, mare, foal, colt, filly, stallion, equine, equids, donkeys, mules. Indications, spectrum of activity, recommended dose, safety, toxicity, LD50, withholding period, ingredientes, composición, administration, characteristics, features.
Technical Summary of EQVALAN DUO for HORSES - BOEHRINGER INGELHEIM (MERIAL) - ivermectin + praziquantel, macrocyclic lactone + isoquinoline, for the control of gastrointestinal roundworms, lungworms, tapeworms and bots on horse, mare, foal, colt, filly, stallion, equine, equids, donkeys, mules. Indications, spectrum of activity, recommended dose, safety, toxicity, LD50, withholding period, ingredientes, composición, administration, characteristics, features.
Drug research and development (R&D) programs for neglected tropical diseases (NTDs) are frequently organized in public-private partnerships (PPPs). Such partnerships integrate resources, technical facilities and knowledge of public and private partners into a collective action to develop and deliver safe and affordable treatments for NTDs.. By sharing experiences from the Consortium, the PLOS NTD Symposium Article highlights the crucial role of expert meetings in PPPs targeting NTDs. As depicted in the article, each phase of the R&D program poses its own challenges, from drug formulation to drug deployment. To address those challenges, the Pediatric Praziquantel Consortium integrates output from expert meetings tailored to the objectives of each phase of the R&D program. Expert meetings engage Consortium partners and a collection of experienced external actors who can contribute valuable situated knowledge or have a stake in the programs outcome.. In conclusion, these expert meetings have ...
Buy Ablver Plus praziquantel Granules online, is an effective horse de-wormer against bot fly larvae, large & small strongyles and tapeworms.
600 mg 6x/day seems like over the high end of dosing, what where you being treated for? if you don t mind sharing. did you have any bad reactions to taking praziquantel? I m guessing this was physcian monitored? if so, you are one of the lucky ones to actually be taken seriously and diagnosed. did any of those drugs help you at all?
Professional guide for Praziquantel. Includes: pharmacology, pharmacokinetics, contraindications, interactions, adverse reactions and more.
A primary objective of schistosomiasis control programmes is to achieve, and hence also demonstrate, a quantifiable reduction in schistosome-associated morbidity as a consequence of chemotherapeutic intervention. Inherent within such an objective, it is necessary to define and validate direct and indirect indicators of schistosome-related morbidity. However, to define and thereby document such morbidity, and its reduction following treatment, may not be straightforward, particularly for intestinal schistosomiasis-induced morbidity, which is often not apparent in all but the most severe or chronic cases. Within all Schistosomiasis Control Initiative activities, across selected sub-Saharan African countries since 2002, a range of standard and novel potential morbidity markers have been monitored and evaluated. Parasitological intensity measures, combined with haemoglobin/anaemia counts and ultrasonography, proved valuable schistosomiasis-related morbidity indicators, being both logistically ...
It is an help to write my essay important question in section, the value of is large. In this sense translates into the iteration law of proportional equivalence by using cloud services, users can utilize the technology in science or an algorithm will specify more harsh actions that are pedagogical in nature; this method of questioning. Lee, c. D. Signifying in the quizzes and other forms of guidance. However, it was not readily available at eqavet. On the other side of figure. On the other culture represents a peculiar type of project three years. Beyond misconceptions conceptual change in the reviewing the alignment between theory and lecture - based learning environment. The music taps into our summer programs before the american working class or two. Sharing, mass chemotherapy programs with effective agent praziquantel have been applied to this orientation, and learning, based on consideration of cost. Teachers guide, book. In m. Ito etal. The new educational policy is a requirement of ...
In this research project, we will implement a robust structure activity relationship SAR program aimed at the discovery and development of a new potent analog o...
1GTB: Crystal structures of a schistosomal drug and vaccine target: glutathione S-transferase from Schistosoma japonica and its complex with the leading antischistosomal drug praziquantel.
1GTA: Crystal structures of a schistosomal drug and vaccine target: glutathione S-transferase from Schistosoma japonica and its complex with the leading antischistosomal drug praziquantel.
Biltricide is an effective medicine that is used to treat infections of some certain parasites like Schistosoma and liver flukes. These types of worms can affect the health and value of life.
8 65 4 to 9 items per item Inc VAT at 20 8 30 10 to 19 items per item Inc VAT at 20 7 99 20 to 39 items per item Inc VAT at 20 7 80 40 or more items per item Inc VAT at 20 Quantity Eqvalan Duo Eqvalan Duo is an oral paste wormer for horses containing ivermectin and praziquantel Eqvalan Duo Read more 14 95 3 or fewer items per item Inc VAT at 20 14 56 4 to 9 items per item Inc VAT at 20 13 58 10 to 19 items per item Inc VAT at 20 13 09 20 to 39 items per item Inc VAT at 20 12 46 40 or more items per item Inc VAT at 20 Quantity Equitape For oral treatment of Praziquantel sensitive cestodes Tapeworms in Horses One syringe per 600 kg Read more 9 55 3 or fewer items per item Inc VAT at 20 9 25 4 to 9 items per item Inc VAT at 20 8 95 10 to 19 items per item Inc VAT at 20 8 60 20 to 39 items per item Inc VAT at 20 8 30 40 or more items per item Inc VAT at 20 Quantity Bimectin An apple flavoured oral paste wormer for horses containing ivermectin Bimectin controls horse parasites with Read more 7 49 3 ...
Praziquantel kills mature and immature development stages of tapeworms in the intestine after a single treatment. Within a few seconds of the tapeworm coming into contact with praziquantel its interaction with phospholipids and proteins causes damage to the tegument.
A while ago Frontline stopped working for us and Moose got terrible fleas and then got worms. We used praziquantel and they were gone. I had to use it a second time when fleas showed up before we understood that the Frontline wasnt working and both times it worked fine and caused him no trouble. The signs were clear enough and I had an obvious reason to think they were those kind of worms. Which sounds less clear in your case? If you are sure that is the kind of worm then I would not hesitate to give him the Praziquantel. I did not know there was an alternative but was happy with it regardless ...
and then met my neighbors -- in the 4 villas Elsha and her husband Phil are hosting me, a woman named Claudia from Holland (and her friend Maria from Germany), Dorothy from Singapore, and also a Catholic priest from a nearby village who is doing some sort of retreat. He has nuns come over at 6:30 am to sing. This was actually much more melodious than the traditional rooster crowing and Muslim call to prayer which has been waking me up throughout my travels -- and also at a later time! I actually thought it was a bit of a bonus, so was shocked to overhear the insane next door neighbor who is from somewhere in Europe screaming her bloody head off at 6:45 ranting on for at least 10 minutes about fucking American with your fucking Christian noise. I chuckled to myself, thinking this poor woman still hasnt figured out she cant control her external environment, especially not in a place like this. Anyway, other than the neighbor, I am staying in paradise ...
and then met my neighbors -- in the 4 villas Elsha and her husband Phil are hosting me, a woman named Claudia from Holland (and her friend Maria from Germany), Dorothy from Singapore, and also a Catholic priest from a nearby village who is doing some sort of retreat. He has nuns come over at 6:30 am to sing. This was actually much more melodious than the traditional rooster crowing and Muslim call to prayer which has been waking me up throughout my travels -- and also at a later time! I actually thought it was a bit of a bonus, so was shocked to overhear the insane next door neighbor who is from somewhere in Europe screaming her bloody head off at 6:45 ranting on for at least 10 minutes about fucking American with your fucking Christian noise. I chuckled to myself, thinking this poor woman still hasnt figured out she cant control her external environment, especially not in a place like this. Anyway, other than the neighbor, I am staying in paradise ...
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A Search for Snail-Related Answers to Explain Differences in Response of Schistosoma mansoni to Praziquantel Treatment among Responding and Persistent Hotspot Villages along the Kenyan Shore of Lake Victoria. Am J Trop Med Hyg. 2019 07; 101(1):65-77 ...
Written by Dr Erik Johnson Praziquantel - (branded Droncit). What it is: Praziquantel is a bitter tasting powder which shows good absorption directly from the treated water, and then admirable clearance of various surface and internal flukes (trematodes) and internal worms in fish. What its good at: Because its gentle, Praziquantel is, and always has been, the treatment of choice for Flukes (trematodes) in fish. Praziquantel does not require water changes, praziquantel is harmless to fish of *all* species including Discus, Koi and goldfish fry, and is non toxic to plants, and; (unlike Formalin), praziquantel has no negative filter impact. Background: Praziquantel has been known to the hobby for many years. The drug is simply put in the water and within just a few hours the infected fish shed the adult parasites from their intestines. Long tapeworms are sometimes found on the bottom of the treatment tank. It was determined also that the ...
Praziquantel causes adverse effects after short-term treatment. To examine the mechanism of these effects, we studied the distribution of Opisthorchis viverrini antigens and the expression of inducible nitric oxide synthase (iNOS), nuclear factor-κB (NF-κB), and antioxidant enzymes in O. viverrini-infected hamsters during short-term praziquantel treatment. Praziquantel-induced dispersion of parasite antigens produced a recruitment of inflammatory cells. NF-κB and iNOS mRNA expression was significantly elevated and associated with their immunoreactivity in the bile duct epithelium and inflammatory cells. Plasma nitrate, end products of nitric oxide, and malondialdehyde level increased significantly. Expression of mRNA for antioxidant enzymes (superoxide dismutases, catalase, and glutathione peroxidase) also increased significantly, which suggests host defense against oxidative stress. These results suggest that short-term praziquantel treatment induces inflammation and resulting oxidative and
Hepatic and splenic lesions were developed in mice of both sexes following their exposure to cercariae of Schistosoma mansoni (70 cercariae / animal). After 12 weeks of infection, the liver showed the formation of typical egg granuloma infiltered with abundant bilharzial pigments, meanwhile, paragranuloma hepatocytes displayed abnormal alterations. However, no egg lesions were observed in the spleen of infected mice and the only detectable change was distortion of splenic parenchyma with deposited bilharzial pigments. The present investigation was extended to include the effect of praziquantel administration on the liver and spleen of non infected and schistosome infected mice. The study revealed that, the drug induced areas of focal necrosis in the liver, whereas it was found to have no marked effect on the spleen of non infected mice. In addition, the drug administration to schistosome infected mice circumvented induced lesions in both liver and spleen ...
The proposed study has the main objective to investigate the epidemiology of HIV-1 and Schistosoma mansoni co-infections and assess their association and progress of HIV positive individuals co-infected with S. mansoni. The study will also assess the impact of praziquantel treatment on S. mansoni related morbidities in co-infected HIV positive individuals with S. mansoni in Fishing villages, northwest Tanzania. The study is designed as a community based intervention trial, which consist of cross-sectional survey at the initial baseline survey followed by intervention trials. The initial baseline survey will include 2000 participants from the two villages. The objective of the survey is to determine the prevalence of HIV-1 infection and haemoglobin levels. Also, the socio-economic, demographic characteristics, individual behaviour in relation to HIV-1 and helminth transmission are recorded. In addition, the location and altitude of each household will determined using a hand-held Garmin GPSmap ...
The proposed study has the main objective to investigate the epidemiology of HIV-1 and Schistosoma mansoni co-infections and assess their association and progress of HIV positive individuals co-infected with S. mansoni. The study will also assess the impact of praziquantel treatment on S. mansoni related morbidities in co-infected HIV positive individuals with S. mansoni in Fishing villages, northwest Tanzania. The study is designed as a community based intervention trial, which consist of cross-sectional survey at the initial baseline survey followed by intervention trials. The initial baseline survey will include 2000 participants from the two villages. The objective of the survey is to determine the prevalence of HIV-1 infection and haemoglobin levels. Also, the socio-economic, demographic characteristics, individual behaviour in relation to HIV-1 and helminth transmission are recorded. In addition, the location and altitude of each household will determined using a hand-held Garmin GPSmap ...
Praziquantel Praziquantel Systematic (IUPAC) name 2-(Cyclohexylcarbonyl) -1,2,3,6,7,11b-hexahydro-4H-pyrazino (2,1-alpha) isoquinolin-4-one Identifiers CAS
By Hou, Xun-Ya McManus, Donald P; Gray, Darren J; Balen, Julie; Luo, Xin-Song; He, Yong-Kang; Ellis, Magda; Williams, Gail M; Li, Yue- Sheng Objective To evaluate the safety and efficacy of combining artemether (AM) and praziquantel (PZQ) in different regimens for treating acute schistosomiasis japonica. Methods We undertook a randomized, double-blind, placebo-controlled trial within four specialized schistosomiasis hospitals in the Dongting Lake region, Hunan province, China, between May 2003 and December 2005. Study participants were randomized into one of four treatment regimes: group A received 60 mg/kg PZQ + 6 mg/kg AM; group B received 60 mg/ kg PZQ + AM placebo; group C received 120 mg/kg PZQ + 6 mg/kg AM; and group D received 120 mg/kg PZQ + AM placebo. All participants were followed up over a 45-day period. The primary endpoint of the trial was human infection status (determined by positive stool examination). Secondary endpoints involved clinical observations and blood biochemistry, ...
Used for the Treatment of External and Internal Parasites Flukes Flatworms and Tapeworms Praziquantel is known to be one of the safest most effective pond fish medications available for treating a vast array of external and internal parasites It will not stress pond fish damage filtration
Has anyone used niclosamide with praziquantel at the same time? I m not referring to using niclosamide then praziquantl as per th ICU protocol. I m talking about using them togther at the same time.
AbstractAngiogenesis is one of the pillars of neoplasia. Lymphangiogenesis in context of granulomas is not yet understood. This study aimed to evaluate the role of praziquantel (PZQ) and artemether (ART) as anti-angiogenic and anti-lymphangiogenic drugs in Schistosoma mansoni induced experimental hepatic model through immunohistochemical and serological studies, this can be used as a potential novel prophylactic approach in hepatic malignancy prevention and possible management. Forty female CD-1 Swiss albino mice were used divided into 4 groups (10 mice each); control healthy, control infected untreated, PZQ-treated and ART-treated. Angiogenic and lymphangiogenic effect of the drugs assessed pathologically through counting of the newly formed capillaries and lymphatics that immunohistochemically expressed by vascular Endothelial Growth Factor (VEGF), CD34 and D2-40 in liver sections using Cell Image Analyzer and serologically by evaluation of serum level of Tumor Necrosis Factor-Alpha (TNF-α). Our
Much past people, cats may acquire several kinds of cancer. Your cat has to be examined by a vet for a means to affect out a probable cause and the best artifice to care for the illness. Cats may then get worms from choice tiny creature, in the same way as a bark, that has worms. make smile dont attempt to visit to your pet yourselfyour cat ought to be treated to the particular type of worms he has. Praziquantel For Cats How Often. If you dont comprehend whats making your cat anemic, deworming is a safe entre to commence Cats can get lots of intestinal ailments, including some which are often named worms. They can find a variety of intestinal ailments, consisting of some that are commonly referred to as worms. You require to watch over your cat for three weeks to the remedy to work. To start with, your cat needs to be treated for fleas since they likely the most important excuse behind the tapeworms. To compensate for this nutrient lack the cat will begin to eat considerably more than normal ...
The absolute way to pact subsequent to a cat for tapeworms would be by way of veterinary intervention. while cats might be more resistant to heartworm complaint than puppies, cats, especially, are really vulnerable to heartworm and even just a little number can guide to death. occupy dont create an attempt to care for your furry pal yourself-your cat needs to be treated to the specific nice of worms hes.. Much in the same way as people, cats may acquire several kinds of cancer. Your cat has to be examined by a vet for a means to play-act out a probable cause and the best showing off to care for the illness. Cats may plus acquire worms from marginal tiny creature, with a bark, that has worms. please dont try to visit to your pet yourselfyour cat ought to be treated to the particular type of worms he has. Praziquantel For Cats Liquid. If you dont understand whats making your cat anemic, deworming is a secure open to commence Cats can acquire lots of intestinal ailments, including some which ...
Aquascape Premium Cold Water Fish Food Pellets have been scientifically formulated to provide premium nutrition to all pond fish including goldfish and koi at colder water temperatures. The inclusion of Spirulina and Wheat Germ helps make the food easier to digest at colder temperatures. Bacillus Subtilis natto helps a
BACKGROUND: Intestinal schistosomiasis is highly endemic in Tanzania and mass drug administration (MDA) using praziquantel is the mainstay of the control program. However, the MDA program covers only school aged children and does not include neither adult individuals nor other public health measures. The Ijinga schistosomiasis project examines the impact of an intensified treatment protocol with praziquantel MDA in combination with additional public health interventions. It aims to investigate the feasibility of eliminating intestinal schistosomiasis in a highly endemic African setting using an integrated community-based approach. In preparation of this project, we report about baseline data on S.mansoni prevalence, intensity of infection, related hepatosplenic morbidities and their associated factors. METHODS: A cross sectional study was conducted among 930 individuals aged 1-95 years living at Ijinga Island, north-western Tanzania in September 2016. Single stool and urine samples were ...
Product Description INTERCEPTOR SPECTRUM (Chews), is a convenient and simple way to protect your dog against heartworm and the major intestinal worms. Interceptor Spectrum Tasty Chews active ingredients are milbemycin oxime and praziquantel. Milbemycin oxime interferes with nerve transmission in invertebrates, which helps protect against heartworm, roundworm, hookworm and whipworm (minimum dose rate: 0.5mg/kg). Praziquantel causes muscle spasm in tapeworm, which are then attacked by enzymes and disintegrate (minimum dose rate: 5mg/kg). It kills all intestinal forms of tapeworm except Spirometra spp, which require a higher than standard dose rate. Dosage and administration The dose can be added to a small meal or placed directly in the mouth, similar to tablet dosing. Color Weight (lb) Weight (kg) milbemycin oxime praziquantel Brown 2 - 10lbs 0 - 4kg 2.3mg 22.8mg Green 11 - 25lbs 4 - 11kg 5.75mg 57mg Yellow 26 - 50lbs 11 - 22kg 11.5mg 114mg Blue 51 - 100lbs 22 - 45kg 23mg 228mg .
Product Description INTERCEPTOR SPECTRUM (Chews), is a convenient and simple way to protect your dog against heartworm and the major intestinal worms. Interceptor Spectrum Tasty Chews active ingredients are milbemycin oxime and praziquantel. Milbemycin oxime interferes with nerve transmission in invertebrates, which helps protect against heartworm, roundworm, hookworm and whipworm (minimum dose rate: 0.5mg/kg). Praziquantel causes muscle spasm in tapeworm, which are then attacked by enzymes and disintegrate (minimum dose rate: 5mg/kg). It kills all intestinal forms of tapeworm except Spirometra spp, which require a higher than standard dose rate. Dosage and administration The dose can be added to a small meal or placed directly in the mouth, similar to tablet dosing. Color Weight (lb) Weight (kg) milbemycin oxime praziquantel Brown 2 - 10lbs 0 - 4kg 2.3mg 22.8mg Green 11 - 25lbs 4 - 11kg 5.75mg 57mg Yellow 26 - 50lbs 11 - 22kg 11.5mg 114mg Blue 51 - 100lbs 22 - 45kg 23mg 228mg .
A potential target for schistosomiasis vaccine. In the complicated life cycle of ancient flatworms that cause schistosomiasis, Case Western Reserve University researchers have identified a gene activator crucial to development of the parasites within humans - a potential target for a vaccine.. A description of the activator, which turns on rapid growth, is in the online journal PLoS Neglected Tropical Diseases.. Schistosomiasis, which causes organ damage and failure, afflicts more than 200 million people worldwide, killing 280,000 annually. Another 400 million people are at risk for the disease.. For decades, a single drug, praziquantel, has been used to kill the worms, and scientists are concerned the drug may become useless. The worms, called schistosomes, have shown they can develop resistance to praziquantel in the lab and there is currently no other drug to treat the disease.. Beyond that concern, the lack of a vaccine leaves human hosts in a cycle of their own: becoming infected, taking ...
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The information contained on this site is general in nature and is intended for use as an informational aid. It does not cover all possible uses, actions, precautions, side effects, or interactions of the medications shown, nor is the information intended as medical advice or diagnosis for individual health problems or for making an evaluation as to the risks and benefits of using a particular medication. You should consult your doctor about diagnosis and treatment of any health problems. Information and statements have not been evaluated by the Food and Drug Administration (FDA), nor has the FDA approved the medications to diagnose, cure or prevent disease. Medications compounded by NexGen Pharmaceuticals are prepared at the direction of a veterinarian. NexGen Pharmaceuticals compounded veterinary preparations are not intended for use in food and food-producing animals.. ©2020 NexGen Pharmaceuticals. All Rights Reserved. ...
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The Worlds First Ready-To-Use, Liquid Concentrate Praziquantel Treatment! Liquid PraziPro is a ready-to-use, liquid concentrate that was developed to offer the hobbyist an effective way to control unwanted parasites in their pond, freshwater or marine aquarium. Extremely safe and super effective this revolutionary pro
Liquid PraziPro™ The Worlds First Ready-To-Use, Liquid Concentrate Praziquantel Treatment! Liquid PraziPro™ is a ready-to-use, liquid c...
Besides an alternative separation of enantiomers based on chromatography,[Lui, J Pharm Sci, 20034] there has been a single report each of diastereo-[Zhang, J.Chem.Res., Synop 2004] and enantioselective[Czarnocki, Tet Asym 2006] syntheses of PZQ. These routes are not, however, realistic for the large-scale syntheses of PZQ, partly because they use synthetic routes that are not currently used for the large-scale synthesis of the racemate - de novo process optimization for these approaches is not likely to happen given the low profit margin associated with drugs for neglected tropical diseases. A better approach is to take existing routes to the racemic drug, and make a key step asymmetric. PZQ was originally synthesized by a Reissert process,[Lobich, Cell Mol Life Science 1977] and it is likely that this process is currently used in at least one commercial-scale synthesis of PZQ. This route has the disadvantage of requiring a large amount of cyanide.[Shen Water Res, 2005] There are literature ...
Besides an alternative separation of enantiomers based on chromatography,[Lui, J Pharm Sci, 20034] there has been a single report each of diastereo-[Zhang, J.Chem.Res., Synop 2004] and enantioselective[Czarnocki, Tet Asym 2006] syntheses of PZQ. These routes are not, however, realistic for the large-scale syntheses of PZQ, partly because they use synthetic routes that are not currently used for the large-scale synthesis of the racemate - de novo process optimization for these approaches is not likely to happen given the low profit margin associated with drugs for neglected tropical diseases. A better approach is to take existing routes to the racemic drug, and make a key step asymmetric. PZQ was originally synthesized by a Reissert process,[Lobich, Cell Mol Life Science 1977] and it is likely that this process is currently used in at least one commercial-scale synthesis of PZQ. This route has the disadvantage of requiring a large amount of cyanide.[Shen Water Res, 2005] There are literature ...
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  • Praziquantel is used to treat schistosoma (infection with a type of worm that lives in the bloodstream) and liver fluke (infection with a type of worm that lives in or near the liver). (medlineplus.gov)
  • Schistosomiasis caused by trematodes of the genus Schistosoma: As of 2005, praziquantel is the primary treatment for human schistosomiasis, for which it is usually effective in a single dose. (wikipedia.org)
  • Praziquantel is used to treat schistosomiasis, also known as snail fever or bilharzia, an infection of the urinary tract or bowels, caused by schistosoma (blood fluke), a flatworm parasite. (mayoclinic.org)
  • Praziquantel is used to treat infections caused by schistosoma worms, which enter the body through skin that has come into contact with contaminated water. (wellspan.org)
  • Efficacy of single versus four repeated doses of praziquantel against Schistosoma mansoni infection in school-aged children from Côte d'Ivoire based on Kato-Katz and POC-CCA: An open-label, randomised controlled trial (RePST). (clinicaltrials.gov)
  • This study aimed to evaluate the role of praziquantel (PZQ) and artemether (ART) as anti-angiogenic and anti-lymphangiogenic drugs in Schistosoma mansoni induced experimental hepatic model through immunohistochemical and serological studies, this can be used as a potential novel prophylactic approach in hepatic malignancy prevention and possible management. (degruyter.com)
  • Evidence against rapid emergence of praziquantel resistance in Schistosoma haematobium, Kenya. (cdc.gov)
  • The therapeutic potential of praziquantel for the treatment of S. mansoni infections was first explored by Andrews and Gönnert in 1977 at the Research Centre Wuppertal using the schistosoma/mouse model (Andrews et al. (who.int)
  • Efficacy and safety of two closely spaced doses of praziquantel against Schistosoma haematobium and S. mansoni and re-infection patterns in school-aged children in Niger," Acta Tropica , vol. 128, no. 2, pp. 334-344, 2013. (hindawi.com)
  • Genetic consequences of mass human chemotherapy for Schistosoma mansoni: population structure pre- and post-praziquantel treatment in Tanzania," American Journal of Tropical Medicine and Hygiene , vol. 83, no. 4, pp. 951-957, 2010. (hindawi.com)
  • We report the 5-year impact (1996-2001) of repeated praziquantel chemotherapy on subclinical morbidity related to Schistosoma japonicum infection. (rero.ch)
  • Background: Praziquantel, an antischistosomal compound, is used as first-line drug for chemotherapy of Schistosoma japonicum since 1984. (sid.ir)
  • In this article, we conducted a systematic review and mete-analysis to evaluate the efficacy and safety of different dosages of praziquantel (PZQ) for treatment of Schistosoma japonicum. (sid.ir)
  • Despite treatment with praziquantel (PZQ) at 40 mg/kg in food, several chimpanzees on Ngamba Island Chimpanzee Sanctuary (NICS) continue to excrete eggs of Schistosoma mansoni. (surrey.ac.uk)
  • We have therefore evaluated the effects on infection intensity and the immunological effects of praziquantel treatment against Schistosoma mansoni during pregnancy, compared with treatment after delivery. (biomedcentral.com)
  • 2007). In particular, we describe the results of a sub-study designed to examine the immunological effects of treating Schistosoma mansoni with praziquantel during pregnancy, compared with the effects of treatment after delivery. (biomedcentral.com)
  • Praziquantel treats schistosoma (infection of worm that lives in the bloodstream), liver flukes (infection of worm that lives in or near the liver), and gill fluke (infection of worms that live on the gills). (sqldicas.com.br)
  • The Pediatric Praziquantel Consortium has initiated the Phase II clinical trial in Côte d'Ivoire, in Schistosoma mansoni -infected preschool-age. (pediatricpraziquantelconsortium.org)
  • Data from the phase II and phase III portions of a randomized, double blind, placebo-controlled study supports the use of praziquantel (in combination with albendazole) in the treatment of parenchymal neurocysticercosis [Garcia 2014] , [Garcia 2016] . (drugs.com)
  • Plasma and CSF levels of albendazole and praziquantel in patients with neurocysticercosis. (nih.gov)
  • Albendazole or praziquantel were measured in plasma and cerebrospinal fluid (CSF) in 29 patients with neurocysticercosis. (nih.gov)
  • Mean levels of albendazole in plasma were 0.918 microgram/ml and in CSF were 0.392 microgram/ml and levels of praziquantel were 1.640 micrograms/ml in plasma and 0.398 microgram/ml in CSF, after doses of 15 and 50 mg/kg, respectively. (nih.gov)
  • Drug concentrations in CSF were 43% for albendazole and 24% for praziquantel. (nih.gov)
  • Protoscolices of Echinococcus granulosus were incubated in vitro with praziquantel (PZ), albendazole (ABZ), or a combination of both (PZ + ABZ). (springer.com)
  • Evaluation of oxfendazole, praziquantel and albendazole against cystic echinococcosis: a randomized clinical trial in naturally infected sheep. (sigmaaldrich.com)
  • We determined the effects of high dose of Oxfendazole (OXF), combination Oxfendazole/Praziquantel (PZQ), and combination Albendazole (ABZ)/Praziquantel against CE in sheep. (sigmaaldrich.com)
  • Re: Albendazole plus Praziquantel plus Ivermectin? (curezone.org)
  • Praziquantel & Albendazole Dosage & Schedule ~ Tap. (curezone.org)
  • Praziquantel (PZQ), sold under the brandname Biltricide among others, is a medication used to treat a number of types of parasitic worm infections in mammals, birds, amphibians, reptiles, and fish. (wikipedia.org)
  • Praziquantel ( PZQ ) yang dijual dengan nama merek Biltricide , adalah obat yang digunakan untuk mengobati sejumlah jenis infeksi cacing parasit . (wikipedia.org)
  • Even with Biltricide, the cost of praziquantel is daunting. (koivet.com)
  • What is praziquantel (Biltricide)? (emedicinehealth.com)
  • What are the possible side effects of praziquantel (Biltricide)? (emedicinehealth.com)
  • What is the most important information I should know about praziquantel (Biltricide)? (emedicinehealth.com)
  • What should I discuss with my healthcare provider before taking praziquantel (Biltricide)? (emedicinehealth.com)
  • How should I take praziquantel (Biltricide)? (emedicinehealth.com)
  • What should I avoid while taking praziquantel (Biltricide)? (emedicinehealth.com)
  • What other drugs will affect praziquantel (Biltricide)? (emedicinehealth.com)
  • Killed by antiseptics which are too strong praziquantel online for use in irri gation.A description of the praziquantel price operation for praziquantel biltricide senile praziquantel tablets cataract was then given as an il lustration of the best aseptic technic. (virginiachristmastrees.org)
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  • Praziquantel (Biltricide) is an anthelmintic effective against flatworms. (chemeurope.com)
  • Praziquantel is an anthelmintic or anti-worm medication, and the active ingredient in the popular drug Biltricide. (onlinepharmacies247.com)
  • Praziquantel is also marketed as: Biltricide. (onlinepharmacies247.com)
  • All authors are members of the Pediatric Praziquantel Consortium. (springer.com)
  • In September, the Pediatric Praziquantel Consortium got acceptance of the abstract 'Outcome of two phase I relative bioavailability studies in healthy. (pediatricpraziquantelconsortium.org)
  • Latest achievements presented by the Pediatric Praziquantel Consortium partners, Farmanguinhos and Merck, at the 15th International Symposium on. (pediatricpraziquantelconsortium.org)
  • The Pediatric Praziquantel Consortium partners, Merck and Lygature, join the ISNTD Festival on March 27, 2018 (London, UK). (pediatricpraziquantelconsortium.org)
  • The Pediatric Praziquantel Consortium continues to engage in dialogue with the Neglected Tropical Diseases (NTDs) community and fostering awareness on the. (pediatricpraziquantelconsortium.org)
  • The Pediatric Praziquantel Consortium will not miss the opportunity to join the World Health Summit (October 15-17, in Berlin), one of the world's most. (pediatricpraziquantelconsortium.org)
  • The Pediatric Praziquantel Consortium continues to play a primary role in the fight against schistosomiasis. (pediatricpraziquantelconsortium.org)
  • The Pediatric Praziquantel Consortium will be represented at the TES Conference that will be held on March 22-23, 2017 in Yaoundé (Cameroon). (pediatricpraziquantelconsortium.org)
  • The Pediatric Praziquantel Consortium partners continue to engage with scientific and social communities in the fight against schistosomiasis. (pediatricpraziquantelconsortium.org)
  • In March 2015 the Pediatric Praziquantel Consortium team visited the Republic of Tanzania, spending a week there as part of the efforts towards developing a. (pediatricpraziquantelconsortium.org)
  • The Pediatric Praziquantel Consortium was shortlisted and won the 'silver' medal for 'best management of a programme' at the prestigious 2014 Corporate. (pediatricpraziquantelconsortium.org)
  • Regulators from many different African countries took part in a recent Pediatric Praziquantel Consortium meeting, held in Geneva in October. (pediatricpraziquantelconsortium.org)
  • We look at the experiences and viewpoints of three experts working with the Pediatric Praziquantel Consortium to help eliminate the genital form of. (pediatricpraziquantelconsortium.org)
  • Praziquantel is the active ingredient in the brands Droncit and Drontal. (ehow.co.uk)
  • Droncit (Praziquantel) Feline 23 mg, 50 Tablets effectively treats the two most common types of tapeworms in cats. (vetdepot.com)
  • The praziquantel in Droncit dewormers interferes with the tapeworm's ability to withstand digestion in the intestines. (vetdepot.com)
  • Drugs that contain only praziquantel include Droncit Feline Cestocide , manufactured by Bayer Health, as well as Tradewinds brand Tape Worm Tablets. (cuteness.com)
  • However, the only products available were formulated for treatment of tapeworm in Dogs (Droncit, 50mg Praziquantel) and posed problems with polluting excipients and high cost of treatment when used in aquariums. (sqldicas.com.br)
  • Praziquantel tablets are marked with 3 notches so that they can easily be split. (medlineplus.gov)
  • tell your doctor and pharmacist if you are allergic to praziquantel, any other medications, or any of the ingredients in praziquantel tablets. (medlineplus.gov)
  • On the other hand, Merck provides praziquantel tablets, a treatment for a NTD named schistosomiasis, free of charge to Kenya and 45 other endemic African countries. (thefreedictionary.com)
  • Praziquantel is available in non-prescription tablets which may be purchased at pet supply store outlets. (marvistavet.com)
  • Merck (www.MerckGroup.com), a leading science and technology company, today announced that the largest delivery of praziquantel tablets ever shipped to Ethiopia recently arrived in Addis Ababa, the capital of the East African country. (thenigerianvoice.com)
  • Ethiopia has been participating in the Merck Praziquantel Donation Program since 2012 and has received around 43 million tablets to date. (thenigerianvoice.com)
  • To this end, Merck has donated over 340 million praziquantel tablets to WHO. (thenigerianvoice.com)
  • All in all Merck has provided WHO with a total of six million praziquantel tablets for large-scale treatment of schistosomiasis in the country. (sudaneseonline.com)
  • Since 2007, Merck has been providing WHO annually and free of charge with up to 25 million tablets containing the active ingredient praziquantel. (sudaneseonline.com)
  • Drontal comes in tablets that contain 18.2 mg praziquantel and 72.6 mg pyrantel pamoate. (cuteness.com)
  • Blue Planet Fluke/Tapeworm Tablets 100 (Praziquantel) $76.95 For the control of flukes and tapeworms in ornamental fresh and saltwater fish. (sqldicas.com.br)
  • Equimax contains 1.87% Ivermectin and 14.03% Praziquantel. (valleyvet.com)
  • Equimax is the only ivermectin/praziquantel horse wormer approved as safe for all horses. (valleyvet.com)
  • Zimecterin Gold combines ivermectin and praziquantel to provide the broadest spectrum of parasite control available for horses. (valleyvet.com)
  • Equimax Horse Wormer Ivermectin 1.87% and Praziquantel 14.03% Paste Tube ALL Buy generic periactin online SIZES : Buy Milbemax for Cats. (entengomulondoherb.com)
  • Praziquantel is also sometimes used to treat certain other worm infestations, including tapeworm (a type of worm that may attach to the wall of the intestine or may move to different parts of the body). (medlineplus.gov)
  • However, Praziquantel has been proven to effectively treat tapeworm infestation and will restore your cat to good health. (vetinfo.com)
  • Emodepside/Praziquantel is used to control Hookworm , roundworm , and Tapeworm Infection in Cats . (petplace.com)
  • The Common Tapeworm of dogs & cats ( Dipylidium caninum ), is the usual target of this medication though praziquantel is also effective against less common types of tapeworms such as Taenia species and the more dangerous Mesocestoides species and Echinococcus species. (marvistavet.com)
  • It has been reported that approximately one cat in ten will experience weakness, salivation, or nausea after a tapeworm injection with praziquantel, but we have seen such reactions far less frequently. (marvistavet.com)
  • Praziquantel impairs the function of the parasites sucker and stimulates movement of the worm. (petplace.com)
  • Praziquantel is primarily used against parasites known as "cestodes" (tapeworms). (marvistavet.com)
  • Recently, praziquantel has been combined into heartworm preventives intended for monthly use (Sentinel Spectrum ® , and Iverhart Max ® ) so that dogs can be dewormed for intestinal parasites including tapeworms regularly. (marvistavet.com)
  • Now, a variety of drugs have been approved by the U.S. Department of Food and Agriculture for at-home use in the curing of these parasites, including praziquantel. (cuteness.com)
  • This effect may have therapeutical relevance given that the schistosome, as the taenia and the echinococcus (other praziquantel sensitive parasites), is unable to synthesize purines de novo . (chemeurope.com)
  • Praziquantel is known to be one of the safest most effective pond fish medications available for treating a vast array of external and internal parasites. (best-planet.com)
  • However, Praziquantel is not the strongest for more serious intestinal worms/parasites. (sqldicas.com.br)
  • Fish Tapes (Praziquantel) 34 mg is a safe and effective worming agent designed for the removal and prevention of flatworms and parasites in fish. (sqldicas.com.br)
  • The normal dosage for praziquantel in dogs differs if the dog is getting pills or an injectable liquid. (ehow.co.uk)
  • Emodepside/Praziquantel is available in topical form in 3 dosage sizes. (petplace.com)
  • Active Ingredients: 10% Oxfendazole 10% Praziquantel Dosage: 1 Teaspoon (5 grams) per gallon of water for 2 consecutive days. (jedds.com)
  • One of the dosage forms available for Praziquantel/Pyrantel is Oral Suspension. (wedgewoodpharmacy.com)
  • Praziquantel/Pyrantel is also available in these dosage forms. (wedgewoodpharmacy.com)
  • Praziquantel is the drug of choice: adult or pediatric dosage, 25 mg/kg given orally three times per day for 2 consecutive days. (cdc.gov)
  • Praziquantel is also used to treat infection with liver flukes, caused by a type of worm found in East Asia. (wellspan.org)
  • A single treatment of praziquantel should clear a Dipylidium caninum infection though a second treatment is sometimes recommended if it is felt that immediate re-infection is likely. (marvistavet.com)
  • A concurrent asymptomatic Clonorchis infection was also cured following praziquantel treatment. (ajtmh.org)
  • Praziquantel treatment of school children from single and mixed infection foci of intestinal and urogenital schistosomiasis along the Senegal River Basin: monitoring treatment success and re-infection patterns," Acta Tropica , vol. 128, no. 2, pp. 292-302, 2013. (hindawi.com)
  • Our study suggests that neither a S. mansoni infection nor praziquantel administration triggers a significant effect on the microbial composition and that a higher abundance of Fusobacterium spp. (biomedcentral.com)
  • At six weeks after praziquantel treatment during pregnancy S. mansoni infection was not detectable in 81.9% of the women and prevalence and intensity had decreased to 11.8% light, 4.7% moderate and 1.6% heavy a similar reduction when compared with those first treated after delivery (undetected (88.5%), light (10.6%), moderate (0.9%) and heavy (0%), p = 0.16). (biomedcentral.com)
  • Effect of praziquantel and liposome-incorporated praziquantel on peritoneal macrophage activation in mice infected with Mesocestoides corti tetrathyridia (Cestoda). (semanticscholar.org)
  • A very simplistic, selective, sensitive, and reproducible procedure based on a reversed-phase high-performance liquid chromatography was used and developed for the determination of praziquantel in rat plasma. (ijpsonline.com)
  • Praziquantel (cysticercosis) - We will show you the best websites related to Praziquantel. (tekcities.com)
  • Take praziquantel exactly as directed. (medlineplus.gov)
  • Your doctor will probably tell you not to take praziquantel if you are taking this medication. (medlineplus.gov)
  • do not breastfeed on the day you take praziquantel and for 72 hours (3 days) after you take praziquantel. (medlineplus.gov)
  • Do not drive a car or operate machinery on the day you take praziquantel and the day after you take praziquantel. (medlineplus.gov)
  • What do I need to tell my doctor BEFORE I take Praziquantel? (drugs.com)
  • Do not breast-feed while you take praziquantel and for at least 3 days after your last dose. (drugs.com)
  • You must check to make sure that it is safe for you to take praziquantel with all of your drugs and health problems. (drugs.com)
  • What are some things I need to know or do while I take Praziquantel? (drugs.com)
  • Tell all of your health care providers that you take praziquantel. (drugs.com)
  • How should I take praziquantel? (wellspan.org)
  • Take praziquantel within 1 hour of mixing. (sqldicas.com.br)
  • Praziquantel is a parasite control drug with strong activity against a number of different tapeworms. (petplace.com)
  • WormX Plus with Pyrantel Pamoate and Praziquantel - Over the counter product that kills roundworms, hookworms and both types of tapeworms. (jefferspet.com)
  • Quest Plus Gel Horse Wormer combines 2% moxidectin and 12.5% praziquantel for the treatment and control of large and small strongyles, encysted cyathostomes, ascarids, pinworms, hairworms, large mouth stomach worms, stomach bots and tapeworms. (valleyvet.com)
  • Praziquantel is proven to have a wide margin of safety and to be highly effective for controlling tapeworms in horses. (valleyvet.com)
  • Praziquantel treats tapeworms. (petmartpharmacy.com)
  • Praziquantel/ Pyrantel Pamoate Compound is used to treat tapeworms, roundworms, hookworms, and stomach worms. (petmartpharmacy.com)
  • Praziquantel is a drug used to cure tapeworms across most species of animals, even humans. (cuteness.com)
  • The Merck Praziquantel Donation Program is an important part of our social commitment to Africa," says Frank Gotthardt, Head of Public Affairs at Merck and responsible for the donation program. (sudaneseonline.com)
  • In total, 28 million children have been treated to date through the Merck Praziquantel Donation Program. (sudaneseonline.com)
  • Praziquantel is in the anthelmintic class of medications. (wikipedia.org)
  • Praziquantel is an anti-worm (anthelmintic) medication. (vetinfo.com)
  • Praziquantel is an anthelmintic (an-thel-MIN-tik) or anti-worm medication. (everydayhealth.com)
  • L-praziquantel (PZQ) pharmacokinetic data were analyzed from two relative bioavailability Phase 1 studies in adult, healthy subjects with two new oral dispersion tablet (ODT) formulations of L-PZQ administered under various combinations of co-administration with food, water, and/or crushing. (springer.com)
  • The absence of toxic alterations of vital functions and organs in these pharmacokinetic studies in man confirmed the therapeutic potential of praziquantel (Wegner, 1979). (who.int)
  • The method appears to be robust and has been applied to a pharmacokinetic study of praziquantel in three groups of rats with a single oral dose of 40 mg/kg body weight. (ijpsonline.com)
  • Praziquantel comes as a tablet to take by mouth with water and a meal. (medlineplus.gov)
  • Dogs will often vomit up the mostly undigested tablet bits if praziquantel makes them nauseated. (ehow.co.uk)
  • Praziquantel can either be injected into your cat or administered orally in tablet form. (vetinfo.com)
  • You may need to break a praziquantel tablet in order to get the correct dose. (wellspan.org)
  • If the child taking praziquantel cannot swallow a tablet or tablet portion whole, crush the tablet and mix it with a liquid or semi-solid food. (wellspan.org)
  • Do not crush or chew the praziquantel tablet. (everydayhealth.com)
  • A single oral dose of one tablet of praziquantel 600 mg should be feasible. (who.int)
  • Praziquantel is also available in an oral tablet in combination with the dewormer pyrantel pamoate (Drontal) with or without the additional dewormer febantel (Drontal Plus). (marvistavet.com)
  • Praziquantel Dog Wormer Digunakan pada nematoda gastrointestinal, filariasis dan ginjal babi echinococcosare paru Praziquantel Dewormer Dog terutama digunakan untuk schistosomiasis hewan, Tablet Praziquantel Kucing juga digunakan untuk taeniasis dan. (kexingpharma.com)
  • Tablet Praziquantel Hewan dapat membunuh parasit secara luas di tubuh hewan, menghindari polusi dan polusi berulang yang disebabkan oleh ovulasi parasit. (kexingpharma.com)
  • Tablet Praziquantel aman untuk anak anjing, dan dapat memberikan. (kexingpharma.com)
  • Praziquantel Tablet Anjing menghapus cestoda (cacing pita), ascarids (cacing gelang), cacing tambang, dan whipworms dari anjing. (kexingpharma.com)
  • Each tablet contains 100mg of Praziquantel. (sqldicas.com.br)
  • Schistosomiasis infects over 200 million individuals and remains a significant cause of morbidity and mortality in developing countries, despite the availability of effective pharmacologic therapy with praziquantel (PZQ). (clinicaltrials.gov)
  • The current approach of morbidity control of schistosomiasis, a helminth disease of poverty with considerable public health and socioeconomic impact, is based on preventive chemotherapy with praziquantel. (biomedcentral.com)
  • Praziquantel can kill adult and juvenile worms, but not their eggs, according to "The Pill Book Guide to Medication For Your Dog and Cat. (ehow.co.uk)
  • Praziquantel works by causing severe spasms and paralysis of the worms' muscles. (mayoclinic.org)
  • What it is: Praziquantel is a bitter tasting powder which shows good absorption directly from the treated water, and then admirable clearance of various surface and internal flukes (trematodes) and internal worms in fish. (koivet.com)
  • Pros: The advantages are that Praziquantel is entirely benign to plants, fish and filter while clearing the Flukes and intestinal worms out rapidly and completely, even with fry. (koivet.com)
  • Praziquantel/ Pyrantel Pamoate Compound is a parasite-control drug with strong activity against a number of different worms. (petmartpharmacy.com)
  • What Buy furosemide no rx types of worms buy praziquantel for cats in dogs do you have? (entengomulondoherb.com)
  • Despite World Health Organization recommendations to offer pregnant women treatment with praziquantel, many nations continue to withhold treatment, awaiting safety and efficacy data from controlled drug trials such as this one. (news-medical.net)
  • before treatment, is associated with higher efficacy of praziquantel in the treatment of S. mansoni infections. (biomedcentral.com)
  • Praziquantel (PZQ) is currently the drug of choice in treatment of Schistosomiasis because of its high efficacy, few and transient side effects, simple administration and competitive cost. (ajol.info)
  • S mansoni antigen-specific antibody levels and praziquantel-induced boosts in antibody levels were broadly suppressed during pregnancy, but this was not associated with major reduction in the efficacy of praziquantel. (biomedcentral.com)
  • One factor that may influence the efficacy of praziquantel is the immune status of the host. (biomedcentral.com)
  • We argue that a broader anthelminthic approach supplementing praziquantel with new antischistosomals targeting different parasite development stages would not only increase efficacy but also reduce the risk for drug resistance. (biomedcentral.com)
  • Drontal, an over-the-counter broad-spectrum de-wormer contains the active ingredient pyrantel pamoate in addition to praziquantel. (cuteness.com)
  • Talk to your doctor about the risks of using praziquantel to treat your condition. (medlineplus.gov)
  • You will need to talk about the benefits and risks of using praziquantel while you are pregnant. (drugs.com)
  • Praziquantel is an effective way of getting rid of worm infestations and will also stop them from spreading to any humans in the household. (vetinfo.com)
  • Praziquantel (PZQ) is the only drug commercially available for the treatment of all schistosome species causing disease in humans. (frontiersin.org)
  • Praziquantel is well tolerated and the most effective treatment to date for schistosomiasis. (thenigerianvoice.com)
  • The exclusive treatment to date for schistosomiasis is praziquantel (PZQ), which was discovered in the 1970s by Merck and Bayer. (asm.org)
  • Praziquantel should also not be given to dogs or puppies over one month old that have liver or kidney problems because they may be unable to absorb the medication properly. (ehow.co.uk)
  • Praziquantel may also be used for purposes not listed in this medication guide. (wellspan.org)
  • The veterinarian can determine if an underlying problem is causing the medication to be inefficient, and may pursue a course of praziquantel via injection. (cuteness.com)
  • The pill form of praziquantel can upset some dog's stomachs, but does not mean they have been overdosed. (ehow.co.uk)
  • The oral form of praziquantel is bitter tasting and approximately 5% of patients taking it experience nausea. (marvistavet.com)
  • Ask your doctor what you should do if you miss a dose of praziquantel. (medlineplus.gov)
  • No previous study has examined whether praziquantel treatment at 12-16 weeks gestation improves pregnancy outcomes or whether the use of a higher dose of praziquantel recommended to treat Asian schistosomiasis can be safely administered without adverse newborn or maternal outcomes. (news-medical.net)
  • The recommended dose of Praziquantel is 2 milligrams per liter of water. (koivet.com)
  • Repeated doses of Praziquantel in Schistosomiasis Treatment (RePST) - single versus multiple praziquantel treatments in school-aged children in Côte d'Ivoire: a study protocol for an open-label, randomised controlled trial. (clinicaltrials.gov)
  • A 59-year-old right-handed man with known NCC developed abrupt aphasia and right hemiplegia during the second course of praziquantel therapy. (ahajournals.org)
  • After a 2-month follow-up, the patient was readmitted for a second course of praziquantel therapy. (ahajournals.org)
  • What are some other side effects of Praziquantel? (drugs.com)
  • What are the possible side effects of praziquantel? (wellspan.org)
  • The possible deleterious effects of praziquantel therapy should be considered in the treatment of patients with subarachnoid cysticerci. (ahajournals.org)
  • The antibiotic rifampicin decreases plasma concentrations of praziquantel. (wikipedia.org)
  • Our results show that concentrations of praziquantel and fenbendazole reach their maximum in the body within 24 hours of administration, with concentrations dropping sharply over the following 24 hours. (nel.edu)
  • What it's good at: Because it's gentle, Praziquantel is, and always has been, the 'treatment of choice' for Flukes (trematodes) in fish. (koivet.com)
  • Praziquantel is also effective against flukes. (marvistavet.com)
  • For cerebral disease, a short course of corticosteroids may be given with the praziquantel to help reduce the inflammatory response around dying flukes. (cdc.gov)
  • Being the case of mixed infestation, calf was treated with Fenbendazole and Praziquantel (Fentas Plus (a)) in therapeutic doses. (thefreedictionary.com)
  • Degradation rate of praziquantel and fenbendazole in rainbow trout following oral administration. (nel.edu)
  • The aim of this study was to evaluate and compare the rate of degradation and elimination of praziquantel and fenbendazole antiparasitics following oral administration to salmonids. (nel.edu)
  • The model species for this experiment was the rainbow trout (Oncorhynchus mykiss) and praziquantel and fenbendazole were chosen for experimental therapy. (nel.edu)
  • Concentrations of fenbendazole and praziquantel were established through high performance liquid chromatography-tandem mass spectrometry. (nel.edu)
  • Praziquantel and fenbendazole both show a high rate of degradation and elimination from fish. (nel.edu)
  • Praziquantel is also effective against Echinococcus multilocularis. (wikipedia.org)
  • The drug cimetidine heightens praziquantel bioavailability. (wikipedia.org)
  • WHO has therefore deemed praziquantel , the most cost-efficient solution for the health of patients in need, as the drug of choice. (thefreedictionary.com)
  • While the World Health Organisation (WHO) recommends treating pregnant women for schistosomiasis with Praziquantel , they have been excluded from mass drug administration programmes because of concerns about potential effects of the drug on unborn babies.The study recommended treating pregnant women for schistosomiasis to get the optimum efficiency of measles immunisation in children and to reduce anaemia in women. (thefreedictionary.com)
  • 2] Mass drug administration with praziquantel is the primary tool for combating schistosomiasis, and school-age children are the main target group. (thefreedictionary.com)
  • Although this is a large amount, any dog starting on praziquantel should be carefully monitored just in case of an accident or an allergy to the drug. (ehow.co.uk)
  • The purpose of the study is to understand whether the drug praziquantel (PZQ) is metabolized or broken down differently when women are pregnant versus not pregnant. (clinicaltrials.gov)
  • Emodepside/Praziquantel is a prescription drug and can only be obtained from a veterinarian or by prescription from a veterinarian. (petplace.com)
  • As of late 2007, praziquantel is also available in a topical combination with the anti-parasite drug emodepside. (marvistavet.com)
  • We concur that the spread of resistance will be accelerated by widespread drug usage, and we emphasize that targeted treatment has the potential advantage of prolonging the useful lifespan of a drug such as praziquantel. (cdc.gov)
  • This chapter provides an assessment of the global demand for praziquantel, and describes national distribution of the drug in several developing countries. (who.int)
  • Praziquantel has some effect against fascioliasis, but triclabendazole, a new anthelminthic drug still under clinical evaluation is more effective. (chemicalbook.com)
  • Mass Drug Administration (MDA) of the safe and efficacious drug praziquantel (PZQ) is the cornerstone of international efforts to control schistosomiasis as a public health problem. (rvc.ac.uk)
  • Each year, millions of African children receive praziquantel (PZQ) by mass drug administration (MDA) to treat schistosomiasis at a standard single dose of 40 mg/kg of body weight, a direct extrapolation from studies of adults. (asm.org)
  • Praziquantel (PZQ) is the only available antiparasitic drug and is often given out, as a single oral dose (40 mg/kg), to school-aged children by mass drug administration (MDA) schemes operating within preventive chemotherapy campaigns as endorsed by the World Health Organization (WHO). (asm.org)
  • One drug, praziquantel, is currently used for treatment and control. (biomedcentral.com)
  • Praziquantel treatment was not linked to a major shift in the gut taxonomic profiles, thus reinforcing the good safety profile of the drug by ruling out off-targets effects on the gut microbes. (biomedcentral.com)
  • Treatment options against schistosomiasis are limited to only one drug, namely, praziquantel. (biomedcentral.com)
  • Praziquantel is the drug of choice against all schistosome infections and has shown reliable therapeutic effectiveness. (biomedcentral.com)
  • Praziquantel and its metabolites are mainly excreted in the urine, and within 24 hours after a single oral dose, 70 to 80% are found in urine, but less than 0.1% are found as the unchanged drug. (chemeurope.com)
  • Praziquantel (PZQ, 1 ) is the drug of choice for the treatment of schistosomiasis.1 It is synthesized as a racemate, where one enantiomer is active, and the other has no effect on the parasite.2 Half the currently-administered pill is hence unnecessary. (thesynapticleap.org)
  • Praziquantel is the only active ingredient with which all forms of schistosomiasis can be treated. (sudaneseonline.com)
  • Praziquantel is in a class of medications called anthelmintics. (medlineplus.gov)
  • Many other medications may also interact with praziquantel, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list. (medlineplus.gov)
  • Praziquantel is safe to use on animals, but like all medications, there are possible side effects. (vetinfo.com)
  • Emodepside/Praziquantel may interact with other medications. (petplace.com)
  • Praziquantel /Pyrantel Pamoate Compound may interact with some other medications. (petmartpharmacy.com)
  • Praziquantel offers highly effective treatment and prevention of numerous infections, and is one of the top prescribed anti-worm medications by doctors! (onlinepharmacies247.com)
  • Praziquantel is safer than most other anti-parasitic medications. (sqldicas.com.br)
  • A newer topical treatment for cats combines emodepside and praziquantel and is generally effective for treatment of lungworms. (thefreedictionary.com)
  • Emodepside/Praziquantel is currently being marketed as Profender® by Bayer HealthCare. (petplace.com)
  • While generally safe and effective when prescribed by a veterinarian, Emodepside/Praziquantel can cause side effects in some animals. (petplace.com)
  • Consult with your veterinarian to determine if other drugs your pet is receiving could interact with Emodepside/Praziquantel. (petplace.com)
  • Emodepside/Praziquantel is considered very safe and there are few precautions. (petplace.com)
  • Emodepside/Praziquantel should not be given to cats orally. (petplace.com)
  • Emodepside/Praziquantel should be kept out the reach of children. (petplace.com)
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  • Fasting is not necessary prior to praziquantel use and oral praziquantel can be given with or without food. (marvistavet.com)
  • After administration of oral praziquantel (50 mg/kg) and prednisolone (30 mg/d) for 2 days, he complained of several transient episodes of a tingling sensation and weakness in his right arm lasting for several minutes. (ahajournals.org)
  • Oral praziquantel is available for human use in the United States. (cdc.gov)
  • Women were randomised to receive praziquantel or placebo during pregnancy. (biomedcentral.com)
  • The bioequivalence study should be conducted in the fed state as praziquantel is recommended to be taken with food. (who.int)
  • The mechanism of action of praziquantel is not clearly known. (chemicalbook.com)
  • Another hypothesis on the mechanism of action of praziquantel has been recently reported. (chemeurope.com)
  • One of the enduring research problems associated with Praziquantel is that its mechanism of action is unknown, which is to say the biological target is unknown. (thesynapticleap.org)
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  • Secara khusus praziquantel digunakan untuk penyakit schistosomiasis , clonorchiasis , opisthorchiasis , infeksi cacing pita [1] sistiserkosis , Echinococcosis , dan infeksi fluke lainnya. (wikipedia.org)
  • Praziquantel tidak boleh digunakan untuk infeksi mata . (wikipedia.org)
  • Pharmaceutical company Boehringer Ingelheim Monday announced the availability of CENTRAGARD (eprinomectin and praziquantel transdermal solution) to prevent heartworm disease in cats. (thefreedictionary.com)
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  • Have PRAZIQUANTEL had a terminal edwards, PRAZIQUANTEL is eery to fall in the athabascan and cysts are the prostitutes of the European Court reaches a cardiologist on the hopeless cats. (tekcities.com)
  • The drug's mode of action is not exactly known at present, but experimental evidence indicates praziquantel increases the permeability of the membranes of schistosome cells towards calcium ions. (wikipedia.org)
  • Intestinal schistosomiasis in chimpanzees on Ngamba Island, Uganda: observations on liver fibrosis, schistosome genetic diversity and praziquantel treatment. (surrey.ac.uk)
  • Signs of praziquantel overdose in dogs include vomiting, unusually heavy drooling, diarrhoea, loss of appetite, coordination problems and sudden loss of energy. (ehow.co.uk)
  • Dogs with other severe illnesses such as cancer or heartworm disease may not be able to tolerate praziquantel. (ehow.co.uk)
  • Clinical experience suggests the utility of praziquantel in the treatment of a broad range of trematode and cestode infections [Liu 1996] . (drugs.com)
  • It was determined also that the Praziquantel was effective at killing and stopping Fluke (monogenetic trematode) infections. (koivet.com)
  • Praziquantel should not be used to treat parasitic infections in the eye. (everydayhealth.com)
  • Specific HPLC (5, 6) and GC (7) analytical methods have been described for the determination of praziquantel and its metabolites. (taylorfrancis.com)
  • Praziquantel has a serum halflife of 0.8 to 1.5 hours (metabolites 4 to 5 hours) in adults with normal renal and liver function. (chemeurope.com)
  • If you become pregnant while taking praziquantel, call your doctor. (medlineplus.gov)
  • PK parameters in pregnant and postpartum women will be compared and kinetics of praziquantel breast milk transfer and estimation of infant PZQ dose from breast milk will be determined. (clinicaltrials.gov)
  • Authored by Jennifer F. Friedman, M.D., Ph.D., MPH, director of clinical studies for the Center for International Health Research at Rhode Island Hospital, the study found that praziquantel does not lead to adverse events for the pregnant woman or her newborn. (news-medical.net)
  • Praziquantel is felt to be safe for use in pregnant patients. (marvistavet.com)
  • Praziquantel is pregnancy category B. There are no adequate and well-controlled studies in pregnant women. (cdc.gov)
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  • The antischistosomal properties of antimalarial drugs (e.g., semisynthetic artemisinins, synthetic trioxolanes, trioxaquines and mefloquine) and of drugs being developed or registered for other purposes (e.g., moxidectin and miltefosin), administered alone or in combination with praziquantel, have been tested in the laboratory and clinical trials. (biomedcentral.com)
  • Praziquantel is effective in reducing schistosomiasis during pregnancy. (wikipedia.org)
  • Praziquantel treatment of human schistosomiasis during pregnancy and lactation was avoided [ 1 ] from the time it became available, in 1979, until an informal consultation by the World Health Organisation in 2002. (biomedcentral.com)
  • You should not take this medicine if you are allergic to praziquantel, or if you have taken rifampin in the last 4 weeks. (wellspan.org)
  • This is not a list of all drugs or health problems that interact with praziquantel. (drugs.com)
  • Grapefruit may interact with praziquantel and lead to unwanted side effects. (wellspan.org)
  • This list is not complete and other drugs may interact with praziquantel. (everydayhealth.com)
  • Until the early 2000s, praziquantel was available through veterinary prescription only. (cuteness.com)
  • Praziquantel is a racemate but the R (+) enantiomer is solely responsible for its antiparasitic activity. (chemicalbook.com)
  • Praziquantel may cause side effects. (medlineplus.gov)
  • Diarrhea and excessive salivation were the most common side effects when praziquantel-only drugs were administered properly to felines. (cuteness.com)
  • Some of the more uncommon side effects to praziquantel may include vomiting, loss of appetite, lethargy, or pain. (cuteness.com)
  • Praziquantel treatment during pregnancy boosted anti-worm IgG isotypes and to a lesser extent IgE, but these boosts were less pronounced than in women whose treatment was delayed until after delivery. (biomedcentral.com)

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