The physiological period following the MENOPAUSE, the permanent cessation of the menstrual life.
The transitional period before and after MENOPAUSE. Perimenopausal symptoms are associated with irregular MENSTRUAL CYCLE and widely fluctuated hormone levels. They may appear 6 years before menopause and subside 2 to 5 years after menopause.
The last menstrual period. Permanent cessation of menses (MENSTRUATION) is usually defined after 6 to 12 months of AMENORRHEA in a woman over 45 years of age. In the United States, menopause generally occurs in women between 48 and 55 years of age.
A sudden, temporary sensation of heat predominantly experienced by some women during MENOPAUSE. (Random House Unabridged Dictionary, 2d ed)
The period before MENOPAUSE. In premenopausal women, the climacteric transition from full sexual maturity to cessation of ovarian cycle takes place between the age of late thirty and early fifty.
The use of hormonal agents with estrogen-like activity in postmenopausal or other estrogen-deficient women to alleviate effects of hormone deficiency, such as vasomotor symptoms, DYSPAREUNIA, and progressive development of OSTEOPOROSIS. This may also include the use of progestational agents in combination therapy.
The concept covering the physical and mental conditions of women.
A major gonadotropin secreted by the adenohypophysis (PITUITARY GLAND, ANTERIOR). Follicle-stimulating hormone stimulates GAMETOGENESIS and the supporting cells such as the ovarian GRANULOSA CELLS, the testicular SERTOLI CELLS, and LEYDIG CELLS. FSH consists of two noncovalently linked subunits, alpha and beta. Within a species, the alpha subunit is common in the three pituitary glycoprotein hormones (TSH, LH, and FSH), but the beta subunit is unique and confers its biological specificity.
Studies in which variables relating to an individual or group of individuals are assessed over a period of time.
The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.
A medical-surgical specialty concerned with management and care of women during pregnancy, parturition, and the puerperium.
A subspecialty of internal medicine concerned with the metabolism, physiology, and disorders of the ENDOCRINE SYSTEM.
The premature cessation of menses (MENSTRUATION) when the last menstrual period occurs in a woman under the age of 40. It is due to the depletion of OVARIAN FOLLICLES. Premature MENOPAUSE can be caused by diseases; OVARIECTOMY; RADIATION; chemicals; and chromosomal abnormalities.
Forward displacement of a superior vertebral body over the vertebral body below.
An INTERVERTEBRAL DISC in which the nucleus pulposus has protruded through surrounding fibrocartilage. This occurs most frequently in the lower lumbar region.
Narrowing of the spinal canal.
A histamine H1 receptor antagonist that is effective in the treatment of chronic urticaria, dermatitis, and histamine-mediated pruritus. Unlike its major metabolite CETIRIZINE, it does cause drowsiness. It is also effective as an antiemetic, for relief of anxiety and tension, and as a sedative.
A loose confederation of computer communication networks around the world. The networks that make up the Internet are connected through several backbone networks. The Internet grew out of the US Government ARPAnet project and was designed to facilitate information exchange.
A semisynthetic derivative of CODEINE.
Lists of words, usually in alphabetical order, giving information about form, pronunciation, etymology, grammar, and meaning.
A heterogeneous group of disorders characterized by HYPERGLYCEMIA and GLUCOSE INTOLERANCE.
A subtype of DIABETES MELLITUS that is characterized by INSULIN deficiency. It is manifested by the sudden onset of severe HYPERGLYCEMIA, rapid progression to DIABETIC KETOACIDOSIS, and DEATH unless treated with insulin. The disease may occur at any age, but is most common in childhood or adolescence.
A subclass of DIABETES MELLITUS that is not INSULIN-responsive or dependent (NIDDM). It is characterized initially by INSULIN RESISTANCE and HYPERINSULINEMIA; and eventually by GLUCOSE INTOLERANCE; HYPERGLYCEMIA; and overt diabetes. Type II diabetes mellitus is no longer considered a disease exclusively found in adults. Patients seldom develop KETOSIS but often exhibit OBESITY.
Dietary practice of completely avoiding meat products in the DIET, consuming VEGETABLES, CEREALS, and NUTS. Some vegetarian diets called lacto-ovo also include milk and egg products.
The edible portions of any animal used for food including domestic mammals (the major ones being cattle, swine, and sheep) along with poultry, fish, shellfish, and game.
Increase in BODY WEIGHT over existing weight.
A diet designed to cause an individual to lose weight.
The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.
Products in capsule, tablet or liquid form that provide dietary ingredients, and that are intended to be taken by mouth to increase the intake of nutrients. Dietary supplements can include macronutrients, such as proteins, carbohydrates, and fats; and/or MICRONUTRIENTS, such as VITAMINS; MINERALS; and PHYTOCHEMICALS.
A vitamin that includes both CHOLECALCIFEROLS and ERGOCALCIFEROLS, which have the common effect of preventing or curing RICKETS in animals. It can also be viewed as a hormone since it can be formed in SKIN by action of ULTRAVIOLET RAYS upon the precursors, 7-dehydrocholesterol and ERGOSTEROL, and acts on VITAMIN D RECEPTORS to regulate CALCIUM in opposition to PARATHYROID HORMONE.
Work-related situations in which the employees as a group refuse to work until certain conditions of employment are granted by the employer.
Calcium compounds used as food supplements or in food to supply the body with calcium. Dietary calcium is needed during growth for bone development and for maintenance of skeletal integrity later in life to prevent osteoporosis.
Reduction of bone mass without alteration in the composition of bone, leading to fractures. Primary osteoporosis can be of two major types: postmenopausal osteoporosis (OSTEOPOROSIS, POSTMENOPAUSAL) and age-related or senile osteoporosis.
Organic substances that are required in small amounts for maintenance and growth, but which cannot be manufactured by the human body.
A specialized CONNECTIVE TISSUE that is the main constituent of the SKELETON. The principle cellular component of bone is comprised of OSTEOBLASTS; OSTEOCYTES; and OSTEOCLASTS, while FIBRILLAR COLLAGENS and hydroxyapatite crystals form the BONE MATRIX.

Glutathione-S-transferase (GSTM1) genetic polymorphisms do not affect human breast cancer risk, regardless of dietary antioxidants. (1/3881)

Glutathione-S-transferases catalyze the detoxication of carcinogen metabolites and reactive oxygen species (ROS) produced through a number of mechanisms. Glutathione-S-transferase (GST) M1 is polymorphic, and the null allele results in a lack of enzyme activity. Because there are indications that ROS may be involved in breast carcinogenesis, we sought to determine whether the GSTM1 null allele was associated with increased breast cancer, particularly among women with lower consumption of dietary sources of alpha-tocopherol, carotenoids and ascorbic acid. In a study of diet and cancer in western New York, women with primary, incident, histologically confirmed breast cancer (n = 740) and community controls (n = 810) were interviewed and an extensive food-frequency questionnaire administered. A subset of these women provided a blood specimen. DNA was extracted and genotyping performed for GSTM1. Data were available for 279 cases and 340 controls. The null allele did not increase breast cancer risk, regardless of menopausal status. There were also no differences in associations between the polymorphism and risk among lower and higher consumers of dietary sources of antioxidants or smokers and nonsmokers. These results indicate that GSTM1 genetic polymorphisms are not associated with breast cancer risk, even in an environment low in antioxidant defenses.  (+info)

Tumour necrosis factor-alpha (TNF-alpha) in human endometrium and uterine secretion: an evaluation by immunohistochemistry, ELISA and semiquantitative RT-PCR. (2/3881)

Tumour necrosis factor-alpha (TNF-alpha is a pleiotropic cytokine synthesized throughout the female reproductive tract. Even though evidence has accumulated that supports its role in autocrine and paracrine processes, its expression and function in the human endometrium are still not completely understood. To gain a better understanding of the synthesis and release of TNF-alpha in the endometrium and how this relates to concentrations in uterine secretion, its expression throughout the menstrual cycle was investigated by three different techniques. Samples of endometrial tissue and uterine secretions were collected from patients undergoing abdominal and vaginal hysterectomy for benign reasons. The mRNA expression of TNF-alpha was investigated in homogenized endometrial tissue by semiquantitative reverse transcription-polymerase chain reaction (RT-PCR) (n = 18). An assessment of the cellular TNF-alpha protein localization in the endometrial glands was performed immunohistochemically (n = 39). The concentrations of the secreted TNF-alpha protein in endometrial secretion were determined by enzyme-linked immunosorbent analysis (n = 30). All three methods gave similar results on the temporal expression of TNF-alpha mRNA and TNF-alpha protein during the cycle. Concentrations of endometrial TNF-alpha mRNA in tissue samples and TNF-alpha protein in uterine secretion were quite low at the beginning of the cycle, rose sharply in the mid- to late proliferative phase and decreased towards the end of the cycle. The concentrations of TNF-alpha protein in the endometrial glands, as shown by immunohistochemical investigation, stayed high throughout the secretory phase at values slightly below those of the late proliferative phase.  (+info)

Cyclical etidronate increases bone density in the spine and hip of postmenopausal women receiving long term corticosteroid treatment. A double blind, randomised placebo controlled study. (3/3881)

OBJECTIVE: To study the effect of cyclic etidronate in secondary prevention of corticosteroid induced osteoporosis. METHODS: A double blind, randomised placebo controlled study comparing cyclic etidronate and placebo during two years in 37 postmenopausal women receiving long term corticosteroid treatment, mainly for polymyalgia rheumatica (40% of the patients) and rheumatoid arthritis (30%). Bone density was measured in the lumbar spine, femoral neck, and femoral trochanter. RESULTS: After two years of treatment there was a significant difference between the groups in mean per cent change from baseline in bone density in the spine in favour of etidronate (p = 0.003). The estimated treatment difference (mean (SD)) was 9.3 (2.1)%. Etidronate increased bone density in the spine (4.9 (2.1)%, p < 0.05) whereas the placebo group lost bone (-2.4 (1.6)%). At the femoral neck there was an estimated difference of 5.3 (2.6)% between the groups (etidronate: 3.6% (1.4)%, p < 0.05, placebo: -2.4 (2.1)%). The estimated difference at the trochanter was 8.2 (3.0) (etidronate: 9.0 (1.5)%, p < 0.0001, placebo: 0.5 (2.3)%). No significant bone loss occurred in the hip in placebo treated patients. CONCLUSIONS: Cyclic etidronate is an effective treatment for postmenopausal women receiving corticosteroid treatment and is well tolerated.  (+info)

Expression of prostate-specific antigen (PSA) correlates with poor response to tamoxifen therapy in recurrent breast cancer. (4/3881)

Prostate-specific antigen (PSA) is a serine protease which may play a role in a variety of cancer types, including breast cancer. In the present study, we evaluated whether the level of PSA in breast tumour cytosol could be associated with prognosis in primary breast cancer, or with response to tamoxifen therapy in recurrent disease. PSA levels were determined by enzyme-linked immunosorbent assay (ELISA) in breast tumour cytosols, and were correlated with prognosis in 1516 patients with primary breast cancer and with response to first-line tamoxifen therapy in 434 patients with recurrent disease. Relating the levels of PSA with classical prognostic factors, low levels were more often found in larger tumours, tumours of older and post-menopausal patients, and in steroid hormone receptor-negative tumours. There was no significant association between the levels of PSA with grade of differentiation or the number of involved lymph nodes. In patients with primary breast cancer, PSA was not significantly related to the rate of relapse, and a positive association of PSA with an improved survival could be attributed to its relationship to age. In patients with recurrent breast cancer, a high level of PSA was significantly related to a poor response to tamoxifen therapy, and a short progression-free and overall survival after start of treatment for recurrent disease. In Cox multivariate analyses for response to therapy and for (progression-free) survival, corrected for age/menopausal status, disease-free interval, site of relapse and steroid hormone receptor status, PSA was an independent variable of poor prognosis. It is concluded that the level of PSA in cytosols of primary breast tumours might be a marker to select breast cancer patients who may benefit from systemic tamoxifen therapy.  (+info)

Menopausal status and distensibility of the common carotid artery. (5/3881)

Although several studies have shown that exogenous estrogens have beneficial effects on arterial characteristics, the effect of endogenous estrogen on the vascular system is still unknown. In this study, distensibility, an indicator of arterial elasticity, of the common carotid artery was compared in pre- and postmenopausal women. The study comprised 93 premenopausal and 93 postmenopausal women of similar age (range, 43 to 55 years). Women were selected from respondents to a mailed questionnaire about the menopause, which was sent to all women aged 40 to 60 years in the Dutch town of Zoetermeer (n=12 675). Postmenopausal women who were at least 3 years past natural menopause or whose menses had stopped naturally before age 48, were age-matched with premenopausal women with regular menses and without menopausal complaints. The selection aimed at maximizing the contrast in estrogen status between pre- and postmenopausal women of the same age. Distensibility of the carotid artery was measured noninvasively with B-mode ultrasound and a vessel wall movement detector system. Arterial distensibility is expressed as the change in arterial diameter (distension, DeltaD) with the cardiac cycle, adjusted for lumen diameter, pulse pressure, and mean arterial blood pressure. Compared with premenopausal women, postmenopausal women had significantly lower arterial distension (DeltaD 370.5 microm [SE 9.5] versus 397.3 microm [SE 9.6]). These results suggest that the distensibility of the common carotid artery is negatively affected by natural menopause in presumed healthy women.  (+info)

Health aspects of partially defatted flaxseed, including effects on serum lipids, oxidative measures, and ex vivo androgen and progestin activity: a controlled crossover trial. (6/3881)

BACKGROUND: Currently there is considerable interest in the potential health benefits of oil seeds, such as soy and flaxseed, especially in relation to cardiovascular disease and cancer. OBJECTIVE: We therefore evaluated health aspects of partially defatted flaxseed in relation to serum lipids, indicators of oxidative stress, and ex vivo sex hormone activities. DESIGN: Twenty-nine hyperlipidemic subjects (22 men and 7 postmenopausal women) completed two 3-wk treatment periods in a randomized, crossover trial. Subjects were given muffins that contributed approximately 20 g fiber/d from either flaxseed (approximately 50 g partially defatted flaxseed/d) or wheat bran (control) while they consumed self-selected National Cholesterol Education Program Step II diets. Both muffins had similar macronutrient profiles. Treatment phases were separated by > or = 2 wk. RESULTS: Partially defatted flaxseed reduced total cholesterol (4.6+/-1.2%; P = 0.001), LDL cholesterol (7.6+/-1.8%; P < 0.001), apolipoprotein B (5.4+/-1.4%; P = 0.001), and apolipoprotein A-I (5.8+/-1.9%; P = 0.005), but had no effect on serum lipoprotein ratios at week 3 compared with the control. There were no significant effects on serum HDL cholesterol, serum protein carbonyl content, or ex vivo androgen or progestin activity after either treatment. Unexpectedly, serum protein thiol groups were significantly lower (10.8+/-3.6%; P = 0.007) at week 3 after the flaxseed treatment than after the control, suggesting increased oxidation. CONCLUSIONS: These data indicate that partially defatted flaxseed is effective in lowering LDL cholesterol. No effects on lipoprotein ratios, ex vivo serum androgen or progestin activity, or protein carbonyl content were observed. The significance of increased oxidation of protein thiol groups with flaxseed consumption requires further investigation.  (+info)

Hormone replacement therapy increases isometric muscle strength of adductor pollicis in post-menopausal women. (7/3881)

A randomized open trial of hormone replacement therapy was used to assess changes in adductor pollicis muscle strength during 6-12 months of treatment with Prempak C 0.625(R) in comparison with an untreated control group. Muscle strength (maximal voluntary force; MVF), muscle cross-sectional area and bone mineral density were measured. Women entering the trial had oestrogen levels below 150 pmol.l-1, confirming their post-menopausal hormonal status. In the treated group, MVF increased by 12.4+/-1.0% (mean+/-S.E.M.) of initial MVF over the duration of treatment, while it declined slightly (2.9+/-0.9%) in the control group. This increase in strength could not be explained by an increase in muscle bulk, there being no significant increase in cross-sectional area during the study. Those subjects who were weakest at enrolment showed the greatest increases in muscle strength after treatment. Bone mineral density in total hip, Ward's triangle and total spine increased in the treated group, in agreement with previous studies. There was no correlation between the individual increases in bone mineral density and those in MVF.  (+info)

Meta-analysis: dietary fat intake, serum estrogen levels, and the risk of breast cancer. (8/3881)

BACKGROUND: There is compelling evidence that estrogens influence breast cancer risk. Since the mid-1980s, dietary fat intervention studies have been conducted to investigate the effect of fat intake on endogenous estrogen levels. To further our understanding of the possible relationship between dietary fat and breast cancer, we conducted a meta-analysis of dietary fat intervention studies that investigated serum estradiol levels, and we reviewed the nature of the evidence provided by prospective analytic studies of fat consumption and breast cancer risk. METHODS: A computerized search of the English language literature on estrogen/estradiol and dietary fat intervention studies published from January 1966 through June 1998 was conducted using the MEDLINE database. Pooled estimates were derived from the change in estradiol levels associated with fat reduction from 13 studies. Analyses were conducted separately for premenopausal and postmenopausal women and in both groups combined. RESULTS AND CONCLUSIONS: Statistically significant reductions in serum estradiol levels of -7.4% (95% confidence interval [CI] = -11.7% to -2.9%) among premenopausal women and -23.0% (95% CI = -27.7% to -18.1%) among postmenopausal women were observed, with an overall -13.4% (95% CI = -16.6% to -10.1%) reduction observed. The greatest reductions occurred in two studies in which dietary fat was reduced to 10%-12% of calories compared with 18%-25% of calories in the other studies. A statistically significant reduction in estradiol levels of -6.6% (95% CI = -10.3% to -2.7%) remained after exclusion of these two studies. Review of prospective analytic epidemiologic studies that allowed for dietary measurement error suggests that the possibility that reducing fat consumption below 20% of calories will reduce breast cancer risk cannot be excluded. IMPLICATIONS: Dietary fat reduction can result in a lowering of serum estradiol levels and such dietary modification may still offer an approach to breast cancer prevention.  (+info)

WASHINGTON, D.C. - Reported mid-life increase in body mass index (BMI) may lead to substantially higher risk of postmenopausal breast cancer, according to results of a prospective cohort study presented at the American Association for Cancer Research 101st Annual Meeting 2010, held here, April 17-21.. In previous studies, excess weight has been linked with increased risk of postmenopausal breast cancer. Scientists have speculated that in postmenopausal women, estrogen produced in adipose tissue, or body fat, may promote breast cell proliferation. Relatively few studies have looked specifically at increase in BMI and its timing in relation to postmenopausal breast cancer risk, which this study investigated.. The researchers analyzed information from 72,007 women in the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial cohort, who were 55 to 74 years old at study entry. The analysis included 3,677 cases of postmenopausal breast cancer, which makes this one of the larger studies of its ...
The Womens Health Initiative (WHI) is a large and complex clinical investigation of strategies for the prevention and control of some of the most common causes of morbidity and mortality among postmenopausal women, including cancer, cardiovascular disease, and osteoporotic fractures. The WHI was in …
Todays women will live more than a third of their lives after menopause, i.e. with a changed hormonal and metabolic state. Vasomotor symptoms like hot flushes and sweating are reported by about 75% of all women around menopause and may impair well-being, mental state, daily activities and night sleep. Vasomotor symptoms are less prevalent in women who participate in regular physical exercise. It is, however, still uncertain if physical exercise reduces vasomotor symptoms.. The purpose of this randomized controlled study is to establish possible beneficial health effects from 15 weeks of supervised resistance training (RT) on postmenopausal women. End-points include effects from RT in postmenopausal women on. ...
TY - JOUR. T1 - Insulin, physical activity, and caloric intake in postmenopausal women. T2 - Breast cancer implications. AU - Chlebowski, Rowan T.. AU - Pettinger, Mary. AU - Stefanick, Marcia L.. AU - Howard, Barbara V.. AU - Mossavar-Rahmani, Yasmin. AU - McTiernan, Anne. PY - 2004/12/1. Y1 - 2004/12/1. N2 - Purpose: Increased physical activity and programs to reduce body mass index (BMI) with both increased physical activity and decreased caloric intake have been proposed to reduce insulin as a potential mediator of breast cancer and other chronic diseases. However, there are few data on the relative contribution of physical activity, caloric intake, and BMI to fasting insulin levels. Materials and Methods: An ethnically diverse subsample of 2,996 mostly healthy postmenopausal women with no prior cancer history was randomly identified from the 161,809 participants in the Womens Health Initiative clinical trials and observational study. Information was collected on diet, recreational physical ...
This is to date the only study that we are aware of investigating the association of change in SS and breast cancer risk. Our data suggests that a unit increase in UK SS (eg, 12-14) every 10 years between the 20s and postmenopausal age increases the risk of postmenopausal breast cancer by 33%. We estimated an increase in 5-year absolute risk of postmenopausal breast cancer from 1 in 61 to 1 in 51 with each unit increase in SS per 10 years. Reductions in SS decreased the risk of breast cancer (figure 2) though it should be noted that for 76% of the women in this study, SS increased over their adult lifetime. These findings may provide women with a simple and easy to understand message given that SS has been found to be a reliable measure for changes in waist circumference and one that women may relate and understand better in comparison to other adiposity measures such as BMI.5. The major strengths of this study are its prospective cohort design, sample size, comprehensive follow-up through ...
PRIMARY OBJECTIVES:. I. Compare the effect of lower and intermittent doses of letrozole to standard letrozole therapy on estrogen suppression in postmenopausal women at high risk for developing breast cancer.. SECONDARY OBJECTIVES:. I. Comparison of the effect of lower and intermittent doses of letrozole to standard therapy on signs and symptoms of estrogen deficiency, including menopausal symptoms, serum lipid profile, and serum marker of bone turnover.. II. Comparison of the effect of lower and intermittent doses of letrozole to standard therapy on nuclear chromatin abnormality of breast epithelial cells collected by random periareolar fine needle aspiration (RPFNA).. TERTIARY OBJECTIVES:. I. Determine the prevalence of breast cancer stem cells in the fine needle breast aspirates and explore the potential intervention effect on the prevalence of breast cancer stem cells.. OUTLINE: Patients are randomized to 1 of 4 treatment arms.. ARM I: Patients receive 2.5 mg of letrozole orally (PO) thrice ...
In this prospective cohort study of Korean postmenopausal women, it is of interest to note that BMI was an independent predictor of mortality for total stroke, particularly for hemorrhagic stroke. The association for death due to the total and hemorrhagic stroke mortality was stronger among women who experienced early menopause but not among those who experienced late menopause. Meanwhile, among total postmenopausal women, BMI was not associated with ischemic stroke mortality, whereas among smoking postmenopausal women, the obese women (BMI ≥27.5 kg/m2) had a significantly high risk of ischemic stroke mortality (adjusted HR, 7.21) in our data.. Although being overweight, particularly obesity, is known to be a risk factor for the incidence or death of cardiovascular disease,16 study results on the relationship between obesity and stroke mortality in Asian populations are not always consistent.3,4,17⇓⇓ Some studies have also noted a substantially increased risk of total and ischemic strokes ...
Evidence continues to mount regarding the health impact of trans fats in ones diet. According to a large new study, trans fats increase the risk of ischemic strokes in postmenopausal women. In addition, the report noted that the risk could be decreased with aspirin (An ischemic stroke is one due to a blockage of an artery, which results in lack of blood supply to a portion of the brain.) The study was published online on March 1 in the Annals of Neurology.. The researchers derived their data from 87,025 generally healthy postmenopausal women aged 50 to 79 years who were enrolled in the Womens Health Initiative Observational Study from 1994 through 1998. The investigators assessed the womens diets via a self-administered food frequency questionnaire. The women were queried regarding their frequency of intake of fats in meat and dairy products, fats used in cooking, added fats, and reduced-fat foods during the previous three months. The women were evaluated at enrollment and at a follow-up ...
A high level of recent, but not historical, physical activity of moderate-to-vigorous intensity is associated with reduced postmenopausal breast cancer risk. More precise recall of recent physical activity than activity in the distant past is one possible explanation for our findings.
AbstractObjective:This study aimed to evaluate self-reported cognitive functioning of postmenopausal breast cancer patients before and during endocrine treatment compared with healthy female controls, and to investigate associations between self-reported cognitive functioning, cognitive test perform
Results: Pre- and post-menopausal women had a median age of 35 (31 to 42) and 57 (52 to 68); body mass index 25 (24 to 28) and 27 (23 to 29), CrCl 86 (58 to 112) and 76 (65 to 104) mL/min, respectively. We enrolled 10 African American and 2 white pre-menopausal women; and 5 African American and 1 Hispanic post-menopausal women. After first dose, blood plasma exposure was similar, but genital tract exposure was increased in post-menopausal women resulting in an increased genital tract : blood plasma ratio. At steady state, post-menopausal women had greater exposure in both blood plasma (p = 0.02) and genital tract (p = 0.01), resulting in similar genital tract : blood plasma ratios. C24h was greater in blood plasma (p = 0.04) and genital tract (p = 0.01) in post-menopausal women at steady state. In post-menopausal women, blood plasma AUC and blood plasma C24h exceed standard pharmacokinetic parameters by 160% and 125%, respectively. ...
Results from a Phase III clinical trial have shown that combining two existing cancer drugs to treat post-menopausal women with advanced breast cancer resistant to hormonal therapy significantly improves outcome. The BOLERO 2 trial showed that women treated with a combination of everolimus and exemestane had an improved progression-free survival of nearly seven months compared to women who were treated only with exemestane. This research will be presented on Sept. 26 at the 2011 European Multidisciplinary Cancer Congress.
A look at the following clinical trial: Anastrozole in Preventing Breast Cancer in Postmenopausal Women at Increased Risk of Breast Cancer.
TY - JOUR. T1 - Alcohol consumption and risk of ductal carcinoma in situ of the breast in a cohort of postmenopausal women. AU - Kabat, Geoffrey C.. AU - Kim, Mimi. AU - Shikany, James M.. AU - Rodgers, Allison K.. AU - Wactawski-Wende, Jean. AU - Lane, Dorothy. AU - Powell, Lynda. AU - Stefanick, Marcia L.. AU - Freiberg, Matthew S.. AU - Kazlauskaite, Rasa. AU - Chlebowski, Rowan T.. AU - Wassertheil-Smoller, Sylvia. AU - Rohan, Thomas E.. PY - 2010/8/1. Y1 - 2010/8/1. N2 - Background: Observational studies have commonly linked higher alcohol consumption with a modest increase in invasive breast cancer risk, but cohort studies have not examined alcohol intake in relation to ductal carcinoma in situ (DCIS). Methods: The association between adulthood alcohol consumption assessed at baseline and subsequent DCIS risk was examined in a cohort of postmenopausal women participating in theWomens Health Initiative clinical trials, in which mammography was protocol-mandated. Alcohol intake was assessed ...
TY - JOUR. T1 - Insulin sensitivity and insulin secretion determined by homeostasis model assessment and risk of diabetes in a multiethnic cohort of women. T2 - The womens health initiative observational study. AU - Song, Yiqing. AU - Manson, Joann E.. AU - Tinker, Lesley. AU - Howard, Barbara V.. AU - Kuller, Lewis H.. AU - Nathan, Lauren. AU - Rifai, Nader. AU - Liu, Simin. PY - 2007/7/1. Y1 - 2007/7/1. N2 - OBJECTIVE - The homeostasis model assessment (HOMA), based on plasma levels of fasting glucose and insulin, has been widely validated and applied for quantifying insulin resistance and β-cell function. However, prospective data regarding its relation to diabetes risk in ethnically diverse populations are limited. RESEARCH DESIGN AND METHODS - Among 82,069 women who were aged 50-79 years, free of cardiovascular disease or diabetes, and participating in the Womens Health Initiative Observational Study, we conducted a nested case-control study to prospectively examine the relations of HOMA ...
The depletion of estrogen and progesterone in postmenopausal women is associated with increased risk for several disorders in the cardiovascular, skeletal and nervous system. To reduce this risk, hormone therapy containing estrogens and a synthetic progestagen has been used but with little success. For example, the Womens Health Initiative clinical trial showed that hormone therapy was associated with reduced incidence of hip fractures associated with osteoporosis but unexpectedly increased incidences of both stroke and dementia. The disparities between basic research studies that demonstrate neuroprotective effects of estrogen and progesterone and recent clinical findings that report adverse neural effects of hormone therapy indicate the need for a more complete understanding of estrogens and progesterone interactions in brain and other tissues. One important issue that is not well understood is how neural effects of estrogens are affected by progestagens. Recent experimental evidence shows ...
The investigators are hypothesizing that decreasing estrogen levels will cause serum DKK1 to peak, then decrease gradually as estrogens reach a new lowe
Genome-wide association studies have identified several genomic regions that are associated with breast cancer risk, but these provide an explanation for only a small fraction of familial breast cancer aggregation. Genotype by environment interactions may contribute further to such explanation, and may help to refine the genomic regions of interest. We examined genotypes for 4,988 SNPs, selected from recent genome-wide studies, and four randomized hormonal and dietary interventions among 2,166 women who developed invasive breast cancer during the intervention phase of the Womens Health Initiative (WHI) clinical trial (1993 to 2005), and one-to-one matched controls. These SNPs derive from 3,224 genomic regions having pairwise squared correlation (r2) between adjacent regions less than 0.2. Breast cancer and SNP associations were identified using a test statistic that combined evidence of overall association with evidence for SNPs by intervention interaction. The combined main effect and interaction
Context: Nutrition plays a vital role in the quality of life in postmenopausal women. Aim: The aim is to determine the dietary intake, physical activity, and assess the body mass index (BMI) among postmenopausal women. Settings and Design: A community‑based sample survey. Materials and Methods: The present study included 140 postmenopausal women (40-70 years) from Udupi, Manipal areas of Karnataka. The study was carried out between July and December 2013. Sociodemographic data were collected using a questionnaire. Anthropometric data included height, weight, waist, and hip circumference. Dietary intake was determined using 24 h dietary recall. Physical activity information was collected. Statistical Analysis Used: Data were analyzed using SPSS version 16 software. Paired t‑test was performed to determine the dietary adequacy. Results: Obesity was 42.1% among the study participants. Increased WHR and waist circumference were 82.1% and 77.1%. Mean daily intake of calcium and saturated fatty ...
Higher estradiol doses had significant benefits for cardiovascular risk factors in early postmenopausal women, but these effects were attenuated in late postmenopausal women.
Data from the Womens Health Initiative Observational Study show that higher than normal insulin levels are an independent risk factor for breast cancer.
TY - JOUR. T1 - Reproductive hormone exposure timing and ischemic heart disease. T2 - Complicated answers to a simple question. AU - Bairey Merz, C. Noel. AU - Shufelt, Chrisandra. AU - Johnson, B. Delia. AU - Azziz, Ricardo. AU - Braunstein, Glenn D.. PY - 2010/4/1. Y1 - 2010/4/1. N2 - The current literature, combined with improved methodology in the WISE study, suggests that there is a beneficial relation between HT use and IHD in peri- and early postmenopausal women. Our results are also consistent with recent clinical trials that have failed to show benefit of HT initiation in older postmenopausal women, either for angiographic coronary disease or cardiac events. Overall, our data suggest that the anti-atherosclerotic effect of HT, if present, may be age-dependent and primarily evident in relatively younger peri- and early postmenopausal women.. AB - The current literature, combined with improved methodology in the WISE study, suggests that there is a beneficial relation between HT use and ...
Aerobic exercise has both neuroprotective and neurorehabilitative benefits. However, the underlying mechanisms are not fully understood and need to be investigated, especially in postmenopausal women, who are at increased risk of age-related disorders such as Alzheimers disease and stroke. To advance our understanding of the potential neurological benefits of aerobic exercise in aging women, we examined anatomical and functional responses that may differentiate women of varying cardiorespiratory fitness using neuroimaging and neurophysiology. A total of 35 healthy postmenopausal women were recruited (59 ± 3 years) and cardiorespiratory fitness estimated (22-70 mL/kg/min). Transcranial magnetic stimulation was used to assess -aminobutyric acid (GABA) and glutamate (Glu) receptor function in the primary motor cortex (M1), and magnetic resonance spectroscopy (MRS) was used to quantify GABA and Glu concentrations in M1. Magnetic resonance imaging was used to assess mean cortical thickness (MCT) of
Evidence from observational studies has suggested the use of oestrogen alone, and oestrogen and progestin therapy (hormone replacement therapy, [HRT]) for postmenopausal women with CHD on the basis of a potential risk reduction in the order of 40% for recurrent events.1, 2. The HERS is the first large scale, randomised controlled trial in which the effects of HRT on CHD mortality and morbidity have been examined in postmenopausal women with established CHD. The findings of no difference in CHD mortality and non-fatal cardiac events, and increases in venous thrombosis among patients in the treated group have led to much discussion in the cardiovascular community.. Past observational studies may have been hampered by selection bias. For example, women who choose to use HRT may already be proactive in managing their health through other behaviours such as exercise and diet, and positive outcomes may have been confounded by this bias.. The increase in venous thrombosis in the treated group is an ...
TY - JOUR. T1 - Factors associated with 5-year risk of hip fracture in postmenopausal women. AU - Robbins, John. AU - Aragaki, Aaron K.. AU - Kooperberg, Charles. AU - Watts, Nelson. AU - Wactawski-Wende, Jean. AU - Jackson, Rebecca D.. AU - LeBoff, Meryl S.. AU - Lewis, Cora E.. AU - Chen, Zhao. AU - Stefanick, Marcia L.. AU - Cauley, Jane. PY - 2007/11/28. Y1 - 2007/11/28. N2 - Context: The 329 000 hip fractures that annually occur in the United States are associated with high morbidity, mortality, and cost. Identification of those at high risk is a step toward prevention. Objective: To develop an algorithm to predict the 5-year risk of hip fracture in postmenopausal women. Design, Setting, and Participants: A total of 93 676 women who participated in the observational component of the Womens Health Initiative (WHI), a multiethnic longitudinal study, were used to develop a predictive algorithm based on commonly available clinical features. Selected factors that predicted hip fracture were ...
After undergoing 5 years of adjuvant endocrine therapy, 2 years of extended anastrozole proved as effective as 5 years for preventing breast cancer recurrence among postmenopausal women with hormone receptor (HR)-positive breast cancer, according to the results of the ABCSG-16 phase III trial.
The results of this randomized clinical trial suggest that exercise can lower levels of circulating estrogens and increase levels of SHBG in previously sedentary, overweight/obese postmenopausal women. The study had excellent retention and adherence, which decreases the chance of biased results and increases study power. The data indicate that loss of body fat in conjunction with exercise is needed to achieve these hormone changes but that exercise need not be of vigorous intensity. This is the first randomized clinical trial to test an exercise intervention on serum estrogens in postmenopausal women, and the results support our hypothesized mechanism that exercise could lower breast cancer risk in postmenopausal women by reducing body fat and ultimately circulating estrogen concentrations. Our observations of a 13.7 and 16.7% decrease in estradiol and free estradiol among exercisers who lost ,2% of body fat are likely to be clinically significant. In comparison, low-fat dietary trials (18-25% ...
Dr. Stefanicks research focuses on chronic disease prevention (particularly, heart disease, breast cancer, osteoporosis, and dementia) in both women and men. Her work on the effects of menopausal hormones on cardiovascular and other health outcomes in mostly healthy postmenopausal women (in the Womens Health Initiative, WHI), in women with established heart disease, (the Heart and Estrogen-progesterone Replacement Study, HERS), and in peri-menopausal and early post-menopausal women (the Postmenopausal Estrogen and Progesterone Interventions, PEPI) trials has been widely disseminated both nationally and internationally. She was also the principal investigator of two large diet trials focusing on the role of a low-fat eating pattern (including increased vegetables & fruits) on preventing breast cancer (WHI) and recurrence (Womens Healthy Eating and Living, WHEL, trial) and she conducted several medium-sized diet, exercise, and weight control trials focused on heart disease risk and body ...
Both obesity and inflammation have been shown to be related to several types of cancer, and this study shows that if reducing weight, can reduce inflammation as well.
Results from this study suggest that the reduced risk of postmenopausal breast cancer associated with frequent episodes strenuous physical activity at 14-22 years of age may be greatest in women who were heaviest within the same time period or who, over the adult years, either lost weight or gained only modest amounts. Among women who were heaviest at age 18, risk of postmenopausal breast cancer was reduced by about 50% in those who exercised frequently.. More pronounced were results obtained from the model examining the joint effects of early-life physical activity and weight change between age 18 and 5 years before interview. Risk of postmenopausal breast cancer was reduced by about 80% among women who were active on a very frequent basis as young adults and who had lost weight between age 18 and 5 years before interview, independent of initial weight. However, given the small sample size of this subgroup, this estimate is unstable. Interestingly, among women with little lifetime weight gain ...
TY - JOUR. T1 - Establishing reference intervals for hCG in postmenopausal women. AU - Patel, Khushbu K.. AU - Qavi, Abraham J.. AU - Hock, Karl G.. AU - Gronowski, Ann M.. PY - 2017/3/1. Y1 - 2017/3/1. N2 - Background Plasma concentrations of human chorionic gonadotropin (hCG) have been shown to increase with age due to pituitary secretion. We previously recommended that an hCG cutoff of 14.0 IU/L be used for women ≥ 55 years of age. However, it remains unknown whether concentrations , 14.0 IU/L can be expected in women with advanced age. Our objectives were to establish plasma hCG reference intervals and correlate follicle stimulating hormone (FSH) and hCG concentrations in postmenopausal females ≥ 55 years. Methods Residual plasma samples from 798 women ≥ 55 years were utilized with 303, 269, and 226 samples belonging to the age groups 55-69, 70-84, and ≥ 85 years, respectively. FSH and hCG were measured using the Abbott ARCHITECT. All positive hCG samples (hCG ≥ 5 IU/L) were ...
Studies have suggested that hormones may play a potential role in melanoma carcinogenesis. Is hormone replacement therapy associated with an increased risk of melanoma in post-menopausal women?Human Reproduction...
We examined the relation of GSTM1, GSTT1, and GSTP1 genotypes and breast cancer risk in a population-based, case-control study of African-American and white women in North Carolina. GSTM1, GSTT1, and GSTP1 genotypes were not associated with breast cancer risk in African-American or white women, or among pre- or postmenopausal women. Two previous studies reported no overall association between GSTM1 genotype and breast cancer risk (19 , 20) . Helzlsouer et al. (9) and Charrier et al. (21) reported positive associations for the GSTM1 null genotype among postmenopausal but not premenopausal women, whereas Ambrosone et al. (22) reported a positive association for GSTM1 null genotype among younger postmenopausal women. In contrast, Garcia-Closas et al. (23) reported no association for GSTM1 null genotype in pre- or postmenopausal women. Helzlsouer et al. (9) reported no association for GSTT1 null genotype and breast cancer in pre- or postmenopausal women, whereas Garcia-Closas et al. (23) observed an ...
Find information about postmenopause and hormones, such as estrogen, progesterone, testosterone, and synthetic hormone treatments.
Use words for any number that begins a sentence, title, subtitle, or heading. However, it may be better to reword the sentence so that it does not begin with a number.Three hundred twenty-eight men and 126 women were included in the study. Better: The study population comprised 328 men and 126 women. Participants: Seventy-two thousand three hundred thirty-seven postmenopausal women aged 34 to 77 years. Better: Participants: A total of 72 337 postmenopausal women aged 34 to 77 years. Three patients were identified; 2 had hypertension and 1 had diabetes. Numerals may be used in sentences that begin
Women with the highest bone mass are at much greater risk of postmenopausal breast cancer than those with lower bone mass, according to the results of a long-term epidemiological study supported by the National Institutes of Health
Fat near heart in women can increase risk of heart attacks and other diseases in women. The threat of such disease increases even further during postmenopausal phase. Apart from heart disease, fat is also responsible for causing increase in cholesterol levels in women. Let us understand how fat near heart is a risk factor for postmenopausal women and how to reduce it.
Health,...Postmenopausal women without symptoms of cardiovascular problems who h...Resting 12-lead electrocardiogram (ECG) abnormalities are independentl...Pablo Denes M.D. of the Feinberg School of Medicine Northwestern Un...The sample analyzed included 14749 postmenopausal asymptomatic women ...,Both,minor,and,major,ECG,abnormalities,linked,with,increased,risk,of,cardiovascular,events,in,women,medicine,medical news today,latest medical news,medical newsletters,current medical news,latest medicine news
Postmenopausal women who lose weight may have a significantly reduced chance of developing breast cancer, according to data presented at the 2017 San Antonio Breast Cancer Symposium, held Dec. 5-9.
ROCHESTER, Minn. -- A daily dose of crushed flaxseed halved hot flashes in postmenopausal women who did not want to take estrogen, according to a pilot study.
To assess the relation between urinary endogenous sex steroid levels and the risk of postmenopausal breast cancer, a nested case-cohort study was conducted within a large cohort (the DOM cohort) in the Netherlands (n=9,349). Until the end of follow-up (1 January 1996), 397 postmenopausal breast cancer cases were identified and a subcohort of 424 women was then taken from all eligible women. Women using hormones were excluded, leaving 364 breast cancer cases and 382 women in the subcohort for the analyses. Concentrations of oestrone, oestradiol, testosterone, 5alpha-androstane-3alpha, 17beta-diol and creatinine were measured in first morning urine samples, which had been stored since enrolment at -20 degrees C. A Cox proportional Hazards model was used, with Barlows adjustment for case-cohort sampling, to estimate breast cancer risk in quartiles of each of the, creatinine corrected, hormone levels, the lowest quartile being the reference group. Women with higher levels of all four of the hormones were
Looking for online definition of postmenopause in the Medical Dictionary? postmenopause explanation free. What is postmenopause? Meaning of postmenopause medical term. What does postmenopause mean?
TY - JOUR. T1 - Axial BMD, change in BMD and bone turnover do not predict breast cancer incidence in early postmenopausal women. AU - Stewart, Alison. AU - Kumar, A.. AU - Torgerson, D. J.. AU - Fraser, W. D.. AU - Gilbert, Fiona. AU - Reid, David M. PY - 2005/12. Y1 - 2005/12. N2 - Previous studies have indicated a relationship between bone mineral density and the incidence of breast cancer in middle-aged and elderly women, with women with higher BMD being at significant increased risk. We investigated whether there was such a relationship in younger women who were perimenopausal or in their early postmenopausal years. As part of a population-screening program for osteoporosis, 5,119 women aged between 45 and 54 years were scanned between 1990-1994 at the Osteoporosis Research Unit. In 1997-2001, 3,884 returned for follow-up scans and questionnaires, and 3,144 returned a postal questionnaire in 2002. All cases of incident breast cancer were noted. One hundred sixty-six women indicated that they ...
Complex ovarian cysts in postmenopausal women are not associated with ovarian cancer risk factors: preliminary data from the Prostate, Lung, Colon, and Ovarian Cancer Screening Trial
A decrease in breast cancer cases is associated with a decreased number of postmenopausal women taking hormone replacement therapy, a new study suggests.. Canadian researchers found that, after the therapys risks were made known in 2002, hormone use by women dropped from 12.7 percent to 4.9 percent between 2002 and 2004. Over the same period, there was a 10 percent decrease in breast cancer cases, according to the study.. The researchers estimated how many women used the hormone replacement therapies by asking 1,200 Canadian women ages 50 to 69 whether they used the therapy between 1996 and 2006.. Hormone replacement therapy was a standard treatment for women in menopause - the hormones lessen hot flashes and other menopausal symptoms. But in 2002, the U.S. Womens Health Initiative clinical trial found that the elevated risk of cancer and stroke associated with long-term use of the therapies did not outweigh the benefits of the therapies themselves.. The researchers also found mammography ...
TY - JOUR. T1 - Metabolic syndrome and postmenopausal breast cancer in the ORDET cohort. T2 - A nested case-control study. AU - Agnoli, C.. AU - Berrino, F.. AU - Abagnato, C. A.. AU - Muti, P.. AU - Panico, S.. AU - Crosignani, P.. AU - Krogh, V.. PY - 2010/1. Y1 - 2010/1. N2 - Background and aims: The increase in breast cancer incidence over recent decades has been accompanied by an increase in the frequency of metabolic syndrome. Several studies suggest that breast cancer risk is associated with the components of metabolic syndrome (high serum glucose and triglycerides, low HDL-cholesterol, high blood pressure, and abdominal obesity), but no prospective study has investigated risk in relation to the presence of explicitly defined metabolic syndrome. We investigated associations between metabolic syndrome, its components, and breast cancer risk in a nested case-control study on postmenopausal women of the ORDET cohort. Methods and results: After a median follow-up of 13.5 years, 163 women ...
URL: https://academic.oup.com/ajcn/article/102/3/573/4564305. Journal: The American Journal of Clinical Nutrition. Publication Date: 09/2015. Summary: Heart associations recommend limited intake of sat- urated fat. However, effects of saturated fat on low-density lipopro- tein (LDL)-cholesterol concentrations and cardiovascular disease risk might depend on nutrients and specific saturated fatty acids (SFAs) in food. We explored the effects of cheese and meat as sources of SFAs or isocaloric replacement with carbohydrates on blood lipids, lipoproteins, and fecal excretion of fat and bile acids. The study was a randomized, crossover, open-label in- tervention in 14 overweight postmenopausal women. Three full- diet periods of 2-wk duration were provided separated by 2-wk washout periods. The isocaloric diets were as follows: 1) a high- cheese (96-120-g) intervention [i.e., intervention containing cheese (CHEESE)], 2) a macronutrient-matched nondairy, high- meat control [i.e., nondairy control with ...
Postmenopause: Find the most comprehensive real-world symptom and treatment data on postmenopause at PatientsLikeMe. 84 patients with postmenopause experience fatigue, depressed mood, pain, anxious mood, and insomnia and use Buprenorphine patch, Hydrocodone-Acetaminophen, Hydroxyzine, Oxycodone-acetaminophen, and Acetaminophen (Paracetamol) to treat their postmenopause and its symptoms.
TY - JOUR. T1 - Are depressive symptoms associated with cancer screening and cancer stage at diagnosis among postmenopausal women? The womens health initiative observational cohort. AU - Aggarwal, Arpita. AU - Freund, Karen. AU - Sato, Alicia. AU - Adams-Campbell, Lucille L.. AU - Lopez, Ana Maria. AU - Lessin, Lawrence S.. AU - Ockene, Judith. AU - Wallace, Robert B.. AU - Williams, Carla D.. AU - Bonds, Denise E.. PY - 2008/10/1. Y1 - 2008/10/1. N2 - Background: Women with depressive symptoms may use preventive services less frequently and experience poorer health outcomes. We investigated the association of depressive symptoms with breast and colorectal cancer screening rates and stage of cancer among a cohort of postmenopausal women. Methods: In The Womens Health Initiative Observational Study, 93,676 women were followed on average for 7.6 years. Depressive symptoms were measured at baseline and at 3 years using the 6-item scale from the Center for Epidemiological Studies Depression scale ...
The USPSTF reviewed evidence from 10 trials that evaluated the effect of risk-reducing medications for breast cancer.3,4 Four trials (n = 28,193) evaluated tamoxifen in premenopausal and postmenopausal women at increased risk for breast cancer13-15,52-60 (in 1 additional trial of low-dose tamoxifen in postmenopausal women not at increased risk for breast cancer,61 the low dose was not found to reduce risk of breast cancer and so was not considered further by the USPSTF); 2 trials (n = 17,806) evaluated raloxifene in postmenopausal women not at increased risk for breast cancer,62-78 1 trial (n = 19,747) directly compared raloxifene with tamoxifen in postmenopausal women at increased risk for breast cancer (STAR trial79-81), and 2 trials evaluated aromatase inhibitors (examestane82,83 [n = 4560] and anastrozole84-86 [n = 3864]) in postmenopausal women at increased risk for breast cancer. Each of the studies that targeted women at increased risk for breast cancer used different combinations of risk ...
TY - JOUR. T1 - Low-fat dietary pattern and risk of treated diabetes mellitus in postmenopausal women. T2 - The womens health initiative randomized controlled dietary modification trial. AU - Tinker, Lesley F.. AU - Bonds, Denise E.. AU - Margolis, Karen L.. AU - Manson, Jo Ann E.. AU - Howard, Barbara V.. AU - Larson, Joseph. AU - Perri, Michael G.. AU - Beresford, Shirley A.A.. AU - Robinson, Jennifer G.. AU - Rodríguez, Beatriz. AU - Safford, Monika M.. AU - Wenger, Nanette K.. AU - Stevens, Victor J.. AU - Parker, Linda M.. PY - 2008/7/28. Y1 - 2008/7/28. N2 - Background: Decreased fat intake with weight loss and increased exercise may reduce the risk of diabetes mellitus in persons with impaired glucose tolerance. This study was undertaken to assess the effects of a low-fat dietary pattern on incidence of treated diabetes among generally healthy postmenopausal women. Methods: A randomized controlled trial was conducted at 40 US clinical centers from 1993 to 2005, including 48 835 ...
Women with benign proliferative breast disease (BPBD) are at increased risk for developing breast cancer. Evidence suggests that accumulation of adipose tissue can influence breast cancer development via hyperinsulinemia, increased estrogen, and/or inflammation. However, there are limited data investigating these pathways with respect to risk of BPBD. We evaluated serologic markers from these pathways in a case-control study of postmenopausal women nested within the Womens Health Initiative Clinical Trial. Cases were the 667 women who developed BPBD during follow-up, and they were matched to 1,321 controls. Levels of insulin, estradiol, C-reactive protein (CRP), and adiponectin were measured in fasting serum collected at baseline. Conditional logistic regression models were used to estimate ORs for the association of each factor with BPBD risk. Among nonusers of hormone therapy, fasting serum insulin was associated with a statistically significant increase in risk of BPBD (OR for highest vs. ...
TY - JOUR. T1 - Dietary intake, physical activity and body mass index among postmenopausal women. AU - Ranasinghe, Chaya. AU - Shettigar, Pallavi G.. AU - Garg, Meenakshi. PY - 2017/10/1. Y1 - 2017/10/1. N2 - Context: Nutrition plays a vital role in the quality of life in postmenopausal women. Aim: The aim is to determine the dietary intake, physical activity, and assess the body mass index (BMI) among postmenopausal women. Settings and Design: A community-based sample survey. Materials and Methods: The present study included 140 postmenopausal women (40-70 years) from Udupi, Manipal areas of Karnataka. The study was carried out between July and December 2013. Sociodemographic data were collected using a questionnaire. Anthropometric data included height, weight, waist, and hip circumference. Dietary intake was determined using 24 h dietary recall. Physical activity information was collected. Statistical Analysis Used: Data were analyzed using SPSS version 16 software. Paired t-test was ...
TY - JOUR. T1 - Examination of the Effect of Nongenetic Risk Factors on the Familial Risk of Breast Cancer among Relatives of Postmenopausal Breast Cancer Patients. AU - Chen, Ping Ling. AU - Sellers, Thomas A.. AU - Potter, John D.. AU - Folsom, Aaron R.. AU - Sellers, Thomas A.. AU - Rich, Stephen S.. AU - Rich, Stephen S.. PY - 1994/10/1. Y1 - 1994/10/1. N2 - Relatives of postmenopausal breast cancer patients have a greater risk of breast cancer than do women with no family history of the disease. However, no study has previously examined the contribution of other breast cancer risk factors to risk in these relatives, thus precluding the ability to discern between shared environment or genes as the cause of familial aggregation. We conducted a nested case-control study of 251 index case families and 234 index control families. Incident breast cancer cases occurring in 1988-1989 and cancer-free controls were selected from a prospective cohort study. A pedigree development form was mailed to ...
TY - JOUR. T1 - Twinship and risk of postmenopausal breast cancer. AU - Cerhan, James R.. AU - Kushi, Lawrence H.. AU - Olson, Janet E.. AU - Rich, Stephen S.. AU - Zheng, Wei. AU - Folsom, Aaron R.. AU - Sellers, Thomas A.. PY - 2000/2/2. Y1 - 2000/2/2. N2 - Background: Intrauterine exposure to high levels of endogenous estrogens has been hypothesized to increase the risk of breast cancer. Because estrogens and other pregnancy hormones are substantially elevated in twin pregnancies, and possibly more so in dizygotic twin pregnancies, we evaluated the association between aspects of twin membership (i.e., belonging to a twin pair) and the risk of breast cancer. Methods: In a cohort of 29 197 postmenopausal Iowa women with no prior diagnosis of cancer (except for nonmelanoma skin cancer), breast cancer risk factors were determined by use of a mailed questionnaire in 1986 (baseline); twin membership, sex of the twin, and zygosity were determined by use of a follow-up questionnaire in 1992. Results: ...
Tager, F.A., McKinley, P.S., Schnabel, F.R. et al. Breast Cancer Res Treat (2011) 126: 271. https://doi.org/10.1007/s10549-009-0684- ...
Kidney cancer incidence is increasing globally. Reasons for this rise are unclear but could relate to obesity and hypertension. We analyzed longitudinal relationships between hypertension and obesity and kidney cancer incidence in 156 774 participants of the Womens Health Initiative clinical trials and observational studies over 10.8 years. In addition, we examined the effect of blood pressure (BP) on kidney cancer deaths for over 25 years among the 353 340 men screened for the Multiple Risk Factor Intervention Trial (MRFIT). In the Womens Health Initiative, systolic BP (SBP) was categorized in 6 groups from ,120 to ,160 mm Hg, and body mass index was categorized using standard criteria. In age-adjusted analyses, kidney cancer risk increased across SBP categories (P value for trend ,0.0001) and body mass index categories (P value for trend ,0.0001). In adjusted Cox proportional hazards models, both SBP levels and body mass index were predictors of kidney cancer. In the MRFIT sample, there were ...
The Endocrine Society - SAN FRANCISCOâ€- Postmenopausal women had better improvement in verbal learning and memory after receiving treatment with testosterone gel, compared with women who received sham treatment with a placebo, a new study found. Results were presented Monday at The Endocrine Societys 95th Annual Meeting in San Francisco.. This is the first large, placebo-controlled study of the effects of testosterone on mental skills in postmenopausal women who are not on estrogen therapy, said principal investigator Susan Davis, MBBS (MD), PhD, of Monash University, Melbourne, Australia. Our study has confirmed our similar findings from two smaller studies in postmenopausal women and suggests that testosterone therapy may protect women against cognitive decline after menopause.. Menopause has been linked with memory decline because of a decrease in levels of the protective hormone estrogen. Yet testosterone also is an important hormone in women because it has a role in sexual desire, ...
TY - JOUR. T1 - Pre-menopausal and post-menopausal depressed women. AU - Roy, Alec. AU - Linnoila, Markku. AU - Jimerson, David C.. AU - Gold, Philip. AU - Pickar, David. PY - 1986. Y1 - 1986. N2 - In a consecutive series of 28 depressed women, pre-menopausal (n = 13) and post-menopausal (n = 15) patients were compared. Post-menopausal women had significantly higher levels of plasma norepinephrine, plasma 3-methoxy-4-hydroxyphenylglycol, post-dexamethasone plasma cortisol, cerebrospinal fluid 3-methoxy-4-hydroxyphenylglycol and corticotropin-releasing hormone. However, when biologic measures were adjusted for age by analyses of covariance there were no significant differences. Pre-menopausal women had had significantly more life events before the onset of depression than post-menopausal women. The implications of these findings are discussed.. AB - In a consecutive series of 28 depressed women, pre-menopausal (n = 13) and post-menopausal (n = 15) patients were compared. Post-menopausal women had ...
Fingerprint Dive into the research topics of Mitotically active leiomyoma of the uterus in a postmenopausal breast cancer patient receiving tamoxifen. Together they form a unique fingerprint. ...
Background: The potential benefits of hormone therapy (HT) in treating depressed postmenopausal women are controversial, and data on depression (re)emergence in the context of HT discontinuation are lacking.. Objective: To determine whether HT is associated with a modified risk of new-onset depressive symptoms in elderly women.. Method: Current depressive symptomatology was evaluated in 4,069 community-dwelling postmenopausal women aged 65 years and over who were randomly recruited from 3 French cities between 1999 and 2001. Depressive symptomatology was assessed using the Center for Epidemiologic Studies-Depression Scale at baseline and as part of the 2- and 4-year follow-up.. Results: Over the follow-up period, multivariate logistic regression analyses adjusted for sociodemographic variables, measures of physical health, and cognitive impairment failed to find a significant association between HT at baseline and the incidence of depressive symptoms. However further analysis indicated an ...
This study investigates whether the incidence of new-onset diabetes mellitus (DM) is associated with statin use among postmenopausal women participating in the Womens Health Initiative (WHI).. [swfobj src=http://www.asociaciondecardiologiadeelsalvador.com/wp-content/uploads/2012/02/statins.swf width=590px height=480px ...
Mathematical methods exist to determine the fractions of sex hormones bound to albumin, bound to sex hormone binding globulin (SHBG), or unbound, using total hormone concentration and SHBG concentration. We used data from eight prospective studies of postmenopausal women to assess the validity of these estimates for fractions of estradiol (E2) and to investigate the impact of using calculated values in breast cancer relative risk (RR) models. Comparisons were made between measured and calculated concentrations of free and non-SHBG-bound E2 in four studies. Relationships between the hormone fractions were investigated and a sensitivity analysis of the calculation performed. Breast cancer RRs were estimated using conditional logistic regression by quintiles of free E2. There is a high correlation (r | 0.91) between calculated and measured values of both free and non-SHBG-bound E2. The calculation is highly sensitive to total hormone concentration but is relatively insensitive to SHBG concentration. In
BACKGROUND: The impact of aromatase inhibitors (AIs) on non-cancer-related outcomes, which are known to be affected by oestrogens, has become increasingly important in postmenopausal women with hormone-dependent breast cancer. So far, data related to the effect of AIs on lipid profile in postmenopausal women is scarce. This study, as a companion substudy of an EORTC phase II trial (10951), evaluated the impact of exemestane, a steroidal aromatase inactivator, on the lipid profile of postmenopausal metastatic breast cancer (MBC) patients. PATIENTS AND METHODS: The EORTC trial 10951 randomised 122 postmenopausal breast cancer patients to exemestane (E) 25 mg (n = 62) or tamoxifen (T) 20 mg (n = 60) once daily as a first-line treatment in the metastatic setting. Exemestane showed promising results in all the primary efficacy end points of the trial (response rate, clinical benefit rate and response duration), and it was well tolerated with low incidence of serious toxicity. As a secondary end point ...
TY - JOUR. T1 - Hot flashes in postmenopausal women treated for breast carcinoma. T2 - Prevalence, severity, correlates, management, and relation to quality of life. AU - Carpenter, Janet S.. AU - Andrykowski, Michael A.. AU - Cordova, Matthew. AU - Cunningham, Lauren. AU - Studts, Jamie. AU - McGrath, Patrick. AU - Kenady, Daniel. AU - Sloan, David. AU - Munn, Rita. PY - 1998/5/1. Y1 - 1998/5/1. N2 - BACKGROUND. Research on hot flashes (HFs) after the diagnosis and treatment of breast carcinoma (BC) is scarce. To our knowledge, this research represents the second study of HF prevalence and severity in women with BC and the first study of 1) correlates of HF prevalence and severity, 2) use of HF management strategies, and 3) the relation between HFs and quality of life (QOL) among women with BC. METHODS. Eligible women (n = 136) participated in structured telephone interviews. RESULTS. Of the 114 postmenopausal women interviewed, 65% reported HFs, with 59% of women with HFs (n = 74) rating the ...
Aim: To examine the association between individual components of metabolic syndrome (MetS) and bone mineral density (BMD) among postmenopausal women. Methods: A total of 177 postmenopausal women participated in a cross-sectional study. They were interviewed to collect anthropometric and demographic characteristics. BMD was measured and biochemical parameters were estimated in fasting blood samples. Univariate and multivariate analyses were used to examine the association between individual components of MetS and BMD. Results: Among 177 postmenopausal women, 116 (66%) had MetS. Women with MetS had significantly higher mean values of BMD and T scores at the total hip (P Conclusions: Body weight and osteocalcin were more strongly associated with bone mass than any other component of MetS in postmenopausal women. However, further studies seem to be needed to confirm their observation.
My research is mainly focused on the effects of cholesterol, saturated fat and statin drugs on health. If you know anyone who is worried about their cholesterol levels and heart disease, or has been told to take statin drugs you could send them a link to this website, and to my statin or cholesterol or heart disease books ...
Multiple epidemiologic and animal studies have established the link between obesity and increased risk for postmenopausal breast cancer. Because obesity is referred to as the epidemic of the 21st century with around 36% of the adult United States women defined as obese and another one third as overweight (1), this disease has a dramatic effect on quality of life as well as on life expectancy in the United States. The estimated increased risk for breast cancer is around 1.3- to 2-fold for obese postmenopausal women as compared with normal-weight postmenopausal women (2, 3). Several mechanisms have been proposed as being responsible for this increased risk for breast cancer. Among those, a well-studied mechanism is altered estrogen biosynthesis, mainly involving increased aromatase expression (4). Aromatase catalyzes the last steps of estrogen biosynthesis from androgens. Estrogen executes its effect mostly by binding to estrogen receptors (ER). Nuclear ERs function as transcription factors and ...
TY - JOUR. T1 - The role of nitric oxide in coronary vascular effects of estrogen in postmenopausal women. AU - Guetta, Victor. AU - Quyyumi, Arshed A.. AU - Prasad, Abhiram. AU - Panza, Julio A.. AU - Waclawiw, Myron. AU - Cannon, Richard O.. PY - 1997/11/4. Y1 - 1997/11/4. N2 - Background: At physiological concentrations, 17β-estradiol selectively enhances endothelium-dependent coronary vasodilation by an unknown mechanism in postmenopausal women. Methods and Results: To assess the contribution of nitric oxide (NO) to the vascular effects of estradiol, we measured coronary epicardial and microvascular responses to intracoronary acetylcholine (range, 3 to 300 μg/min for 2 minutes) before and after intracoronary estradiol 75 ng/min for 15 minutes in 20 estrogen-deficient women, 16 of whom had angiographic evidence of atherosclerosis or risk factors for atherosclerosis. This testing was repeated after inhibition of NO synthesis with intracoronary N(G)-monomethyl-L-arginine (L-NMMA) 64 μmol/min ...
A new study suggests drinking cows milk may increase breast cancer risk in postmenopausal women, but an expert warns that the study is observational and the data should not be over-inflated.
Studies done in different ethnic groups indicate that postmenopausal women are more salt-sensitive than premenopausal women, suggesting that decreases in ovarian hormone levels and increased sensitivity to dietary sodium may be important factors in the genesis of postmenopausal hypertension.4-6 The DS and DR rat strains developed by Dahl have been useful as an animal model for the study of salt-sensitive hypertension. One of the defects characterized in this form of hypertension is a blunted pressure-natriuresis relation, so that a higher blood pressure is needed to achieve the same level of sodium excretion. Short-term studies performed by Otsuka et al25 demonstrated this antinatriuretic shift in the pressure-natriuresis relation in DS rats compared with DR rats. OVX further impaired the pressure-natriuresis response in DS but not DR rats. These investigators, however, did not study whether OVX fostered hypertension.. In the present study, we have shown that in salt-sensitive DS rats, despite a ...
Genetic factors are essential for the introduction of sarcopenia, a geriatric disorder seen as a low lean muscle mass. analyses uncovered the need for the gene in the rules of lean muscle mass. gene, rs10514346, can be an applicant BMD-related polymorphism. The association of rs10514346 with BMD was replicated within an evaluation of data through the Framingham Heart Research. Here, we record a large-scale association research for low lean muscle mass using Affymetrix 250K SNP arrays in an example of 269 unrelated postmenopausal Japanese ladies. The association of the SNP (rs12409277) situated in the 5-flanking area from the (PRD1-BF-1-RIZ1 homologous site containing proteins 16) gene was additional verified in another postmenopausal Japanese Nexavar ladies human Nexavar population comprised 1081 topics. Results We utilized the Affymetrix 250K SNP GeneChip (262 000 SNPs) to examine the hereditary association of SNPs with lean muscle mass adjusting with age group in 269 topics. The mean (SD) age ...
Risks and Benefits of Estrogen Plus Progestin in Healthy Postmenopausal Women: Principal Results From the Womens Health Initiative Randomized Controlled Trial. Writing Group for the Womens Health Initiative Investigators. JAMA. 2002;288(3):321-333. Available at: http://jama.ama-assn.org/cgi/content/full/288/3/321 ...
On June 4, 2011, research was presented at the American Society of Clinical Oncology conference regarding the use of the drug exemestane (Aromasin), an aromatase inhibitor, for use in healthy postmenopausal women to reduce the risk of invasive breast cancer.. The authors conclude that exemestane reduces the risk of breast cancer for postmenopausal women over the 3 years of follow up in the study. In the study side effects such as hot flashes, fatigue sweating, insomnia and arthralgia were more common in women on exemestane but didnt affect overall self reporting on quality of life. The study was led by Canadas NCIC Clinical Trials Group and financed in part by the pharmaceutical giant Pfizer, which manufactures Aromasin.. Read on for BCActions opinion on this new study and pills for prevention in general.. Need robust definition of High Risk When exploring prophylactic treatment for breast cancer in healthy women, the bar needs to be especially high. By failing to adopt a rigorous ...
Mammographic density (MD) is one of the strongest known breast cancer risk factors. Estrogen and progestin therapy (EPT) has been associated with increases in MD. Dense breast tissue is characterized by increased stromal tissue and (to a lesser degree) increased numbers of breast epithelial cells. It is possible that genetic factors modify the association between EPT and MD, and that certain genetic variants are particularly important in determining MD in hormone users. We evaluated the association between MD and 340 tagging single nucleotide polymorphisms (SNPs) from about 30 candidate genes in hormone metabolism/growth factor pathways among women who participated in the Norwegian Breast Cancer Screening Program (NBCSP) in 2004. We assessed MD on 2,036 postmenopausal women aged 50 to 69 years using a computer-assisted method (Madena, University of Southern California) in a cross-sectional study. We used linear regression to determine the association between each SNP and MD, adjusting for potential
The Menopause and Postmenopause. pp. 43-52. doi:10.1007/978-94-011-7230-1_5. ISBN 978-94-011-7232-5. Prossnitz ER, Arterburn JB ...
52-. ISBN 978-3-662-40303-7. Rodolfo Paoletti; N. Pasetto; J.L. Ambrus (6 December 2012). The Menopause and Postmenopause: The ... The Menopause and Postmenopause. pp. 43-52. doi:10.1007/978-94-011-7230-1_5. ISBN 978-94-011-7232-5. Vern L. Bullough (19 May ...
Heimer GM (1987). "Estriol in the postmenopause". Acta Obstet Gynecol Scand Suppl. 139: 1-23. doi:10.3109/00016348709156470. ...
Trockel's work often criticises the work of other artists, or artistic styles such as minimal art.:252 2005: Post-Menopause, ... Barbara Engelbach (2005). Rosemarie Trockel: Post-menopause (exhibition catalogue). Köln: Gesellschaft für Moderne Kunst am ... Post-Menopause, at the Museum Ludwig in Cologne in 2005.:252 In 2011 Trockel won the Wolf Prize for painting. In 2012 an ...
... menopause or postmenopause can be identified by a blood test showing a very high FSH level. Thus postmenopause is the time in a ... Postmenopause[edit]. The term "postmenopausal" describes women who have not experienced any menstrual flow for a minimum of 12 ... The reason for this delay in declaring postmenopause is because periods are usually erratic at this time of life. Therefore, a ... The menopausal transition, and postmenopause itself, is a natural change, not usually a disease state or a disorder. The main ...
They manage biological females' healthcare from puberty through post-menopause. With appropriate training, they can also first- ...
The problem is greater in women who are post-menopause. In males, it is most closely associated with delayed ejaculation. ...
For pre-menarche girls and for post-menopause women - three months. In case of pregnancy, after the delivery of the child. ...
Thus postmenopause is the time in a woman's life that takes place after her last period or, more accurately, after the point ... In women without a uterus, menopause or postmenopause can be identified by a blood test showing a very high FSH level. ... The reason for this delay in declaring postmenopause is because periods are usually erratic at this time of life. Therefore, a ... The menopausal transition, and postmenopause itself, is a natural change, not usually a disease state or a disorder. The main ...
There may be an increase in heart disease if HRT is given twenty years post-menopause. This variability has led some reviews to ... Sarrel, P.M. (2000). Effects of hormone replacement therapy on sexual psychophysiology and behavior in postmenopause. Journal ... postmenopause'. Premature menopause can occur if the ovaries are surgically removed, as can be done to treat ovarian or uterine ...
Postmenopause und Hormonsubstitution [Climacteric, Postmenopause and Hormone Replacement] (in German) (4 ed.). UNI-MED-Verlag. ...
Kuhl, Herbert; Wiegratz, Inka (1 January 2008). Klimakterium, Postmenopause und Hormonsubstitution [Climacteric, Postmenopause ... Wiegratz, I.; Kuhl, H. (2007). "Praxis der Hormontherapie in der Peri- und Postmenopause" [Practice of peri- and postmenopausal ...
Following the development of the vulva, changes take place at birth, childhood, puberty, menopause and post-menopause. There is ... Rimoin, Lauren P.; Kwatra, Shawn G.; Yosipovitch, Gil (2013). "Female-specific pruritus from childhood to postmenopause: ...
Menopausal hormone therapy is not currently approved for the treatment of depressive symptoms in the peri- or postmenopause in ... Research on combined estrogen and progestogen therapy for depressive symptoms in the peri- and postmenopause is scarce and ... Wiegratz, I.; Kuhl, H. (2007). "Praxis der Hormontherapie in der Peri- und Postmenopause" [Practice of peri- and postmenopausal ... and postmenopause. There is some evidence that estrogens are effective in the treatment of depression in perimenopausal women. ...
The Menopause and Postmenopause: The Proceedings of an International Symposium held in Rome, June 1979. Springer Science & ...
Gynodian-depot in the treatment of castration-induced postmenopause]. Jugosl Ginekol Perinatol (in Croatian). 27 (1-2): 37-40. ...
430-. ISBN 978-1-4757-2085-3. Rodolfo Paoletti; N. Pasetto; J.L. Ambrus (6 December 2012). The Menopause and Postmenopause: The ...
An android fat distribution becomes more common post-menopause, where oestrogen is at its lowest levels. Older men show android ...
2014). ""Phytoestrogens in postmenopause " the state of the art from a chemical, pharmacological and regulatory perspective". ...
... and post-menopause". Female and Male Climacteric. pp. 43-67. doi:10.1007/978-94-011-9720-5_6. ISBN 978-94-011-9722-9. Mattson ...
... especially in and post-menopause. Changes in sex hormones in both men and women as they age may account in part for increased ...
... and postmenopause life stages". Archives of Women's Mental Health. 10 (6): 247-257. doi:10.1007/s00737-007-0209-5. PMID ...
Estrogens and progestogens in the menstrual cycles and during premenarche and postmenopause are also similar in female humans ...
It chiefly affects adults from premenarche to postmenopause, regardless of race or ethnicity or whether or not they have had ...
... estrogen levels fluctuate during the menstrual cycle but reach a steady decline and then remain at low levels postmenopause. ... widely found that this treatment must be administered near to the onset of menopause as opposed to several years postmenopause ...
Similarly for non-menstruating women, including post-menopause women and pre-menarche girls, At-Talaq 65:4 prescribes the ...
Menerba Rimostil Poluzzi E, et al Phytoestrogens in postmenopause: the state of the art from a chemical, pharmacological and ...
Young men were introduced to male continence by women who were post-menopause, and young women were introduced by experienced, ...
... menopause and postmenopause. Stewart is currently partnered with Virgin Care to deliver menopause services in the workplace. ...
Clinical recovery from depression postpartum, perimenopause, and postmenopause was shown to be effective after levels of ...
Disclaimer: The information provided on HealthWorld Online is for educational purposes only and IS NOT intended as a substitute for professional medical advice, diagnosis, or treatment. Always seek professional medical advice from your physician or other qualified healthcare provider with any questions you may have regarding a medical condition ...
Post Menopause Clinical Trials. A listing of Post Menopause medical research trials actively recruiting patient volunteers. ... Post Menopause Study Currently we have the following studies: Birth Control/ Contraceptive Vaginal Atrophy Pain During ...
Postmenopause and estrogen, postmenopausal women are at higher risk for these health conditions, safe and effective ... Learn about post menopause symptoms. Bioidentical menopause and natural treatment. Best source of progesterone and natural ... During postmenopause, women need to maintain an optimal weight. If you are overweight, you should exercise daily to control ... With exercise, postmenopause women have better sex lives. Exercise is known to improve your mood, and it boosts your immune ...
84 patients with postmenopause experience fatigue, depressed mood, pain, anxious mood, and insomnia and use Buprenorphine patch ... Find the most comprehensive real-world symptom and treatment data on postmenopause at PatientsLikeMe. ... What is postmenopause?. The time of a womans life following menopause is called postmenopause. At this time symptoms ... 0 evaluations from postmenopause patients report that they could not tell effectiveness of Hydroxyzine for anxious mood (0%) ...
... Post-menopause, or the period after menopause, begins when a woman has not had a menstrual ... During post-menopause, many women find that they feel liberated. They no longer have to worry about their menstrual cycles and ... It is not uncommon for women in post-menopause to go back to school, start a business, write a book or begin traveling in ... A woman in recovery has a doubly hard task during menopause and post-menopause. She must learn how to navigate not only the ...
Change in marital status post-menopause may impact health. University of Arizona. Journal. Journal of Womens Health. Keywords ... change-marital-status-postmenopause-may-impact-health Related Journal Article. http://dx.. doi.. org/. 10.. 1089/. jwh.. 2016. ...
Post-menopause myth 1: Your desire for sex will end with your periods.. The facts: Desire levels differ among women. "Women of ... Post-menopause myth 4: You can stop worrying about birth control and safe sex. The facts: Want a baby to liven up your middle ... Post-menopause myth 6: Youre too old to kick things up a notch. The facts: The longer a couple has been together, the greater ... Post-menopause myth 7: You can take a break from sex now without negative consequences later. The facts: "The principle of use ...
... postmenopause explanation free. What is postmenopause? Meaning of postmenopause medical term. What does postmenopause mean? ... Looking for online definition of postmenopause in the Medical Dictionary? ... postmenopause. postmenopause. (pōst″mĕn′ō-pawz″) [″ + ″] The phase of a womans life that begins 1 year after her final ... But what you may not know is that the first three to five years postmenopause are the most crucial for bones.. Best exercises ...
Menopause, Perimenopause and Postmenopause Menu Overview Diagnosis and Tests Management and Treatment Outlook / Prognosis ...
Its no surprise that diet, nutrition and exercise are regarded as the most important factors in not only reducing diabetes, but controlling it.
Smoking Before Menopause Increases Breast Cancer Risk, Post Menopause May Lower Risk. Never smoking and passive smoking in ...
Home » Community » Lean, Mean Vegan Machine » Menopause or post menopause vegan weight gain ...
Postmenopause Weight Gain and Increase in Bad Cholesterol May Contribute to Artery Damage. ...
BERTULUCCI, Lívia de Almeida Barros et al. Periodontal disease in women in post-menopause and its relationship with ... Palavras-chave : Osteoporosis; Postmenopause; Periodontal diseases. · resumo em Português · texto em Português · Português ( ...
... Sol s-Cabrera BH, Ram rez- ... Objective: to evaluate urinary desoxypiridinoline (Dpd) levels in postmenopause patients, with osteoporosis or osteopenia after ...
Diet to Increase Metabolism Post Menopause. While exercise is obviously an important factor to increase metabolism post ... This is especially true for those who are post menopause. * Swimming-Proclaimed as the perfect, low-impact exercise, swimming ... Most women need to increase metabolism post menopause in order to battle weight and overall health issues. As women age, lean ... Exercise classes-Programs, such as low-impact aerobics and Pilates are perfect for those who are post menopause. ...
Menopause and postmenopause can be scary times for women who dont know what to expect. Learn about the risk of ovarian cancer ... If you want to learn more about postmenopause, click on the link below to find out about postmenopause treatments. ... Are Ovarian Cysts Common in Postmenopause?. Many women appreciate finishing up menopause and entering postmenopause because ... Menopause and postmenopause can be alarming for women who dont know what to expect. With hormones and emotions running wild it ...
In the early postmenopause group, HT slowed the development of atherosclerosis. In the late postmenopause group, it did not. ... Early postmenopause women can benefit from hormone therapy. ASK DOCTOR K Anthony L. Komaroff, M.D. Published 8:48 p.m. PT July ... Early postmenopause women can benefit from hormone therapy. Hormone therapy usually involves a combination of both estrogens ( ... Early postmenopause women can benefit from hormone therapy Hormone therapy usually involves a combination of both estrogens ( ...
... 18 Jan 2021 10:00:00 , Author: Caryl ... including post-menopause. It is a natural part of life, yet not everyone experiences the same symptoms. Some suffer them with ...
Is there any chance for bleeding in post menopause stage?. Yes! There is a chance for vaginal bleeding during your post ... How can you know that you are in the stage of post menopause?. If you lack the symptoms of menopause like hot flashes, ... Post menopause bleeding can also occur during certain emotional events like if you are meeting your children after a long gap ... Post menopause is the last stage in four stage process of menstruation, which brings an end to your reproductive cycle. ...
A study that examined the prevalence and correlates of vaginal estrogenization in postmenopausal women in the United States found that in every age group, vaginal estrogenization was _______________ among postmenopausal nonusers of hormone therapy in the 2005 to 2006 cohort, compared with historical clinical data. ...
... which is common during the postmenopause period, is associated with an array of health problems, including diabetes and heart ... How much postmenopause weight gain can be blamed on weight-promoting medications?. July 15, 2020. CLEVELAND, Ohio (July 15, ... 2020)--Abdominal weight gain, which is common during the postmenopause period, is associated with an array of health problems, ...
Post Menopause Cholesterol. In 2009, the organizers of a medical study published in the Journal of the American College of ...
YOU ARE HERE: Home , About ACC , Press Releases , Regular-Walking-May-Protect-Against-Heart-Failure-Post-Menopause ... Regular Walking May Protect Against Heart Failure Post Menopause. Brisk walks lasting 40 minutes or more, two to three times ...
About Post Menopause. What is Post Menopause?. Postmenopause is the fourth and last stage of the menopause process. Technically ... Post Menopause 11.11.2015 Postmenopause can come across as an enigmatic time of life -the first time in decades that a woman ... Understanding Post Menopause. When women reach postmenopause, they will regain a sense of control of their bodies. By then, the ... External Causes of Post Menopause. Even though hormone changes are at the very foundation of postmenopause there are a number ...
Post menopause) l have had brown blood after sex. Should l the wait and see if it happens again or go to my gyn? ... Post menopause but LH and FSH are above upper limits. 81.4 and 197.6 respectively. Normal or cause for concern? (no hrt) ... 15 yrs post menopause. I do not know my biological mother, or her health history. Should I get the brca2 test? ... Post menopause: What? You are an 18 year-old post menopausal male? Please take the time to ask a proper question if you are ...
expert reaction to story reporting the rejuvenation of womens ovaries post-menopause A group of scientists have reported a way ... expert reaction to story reporting the rejuvenation of womens ovaries post-menopause ...
I get asked regularly, "Whats the post-menopause going to be like? How am I going to feel? Whats going to happen? What is my ... Today on A.Vogel Talks Menopause, Im going to be talking about six things you need to know about the post-menopause. ... If any of you out there have any great tips for looking after yourself post-menopause, let us know. Also, let us know how ... So today, I thought that I would go through some of the most common post-menopause questions that I get asked regularly, as ...
Latest News » Study: Vitamin D and calcium supplements may promote bone health post-menopause. ...
Atherogenic lipid profile and health behaviours in women post-menopause working in agriculture ...
  • The Perimenopause Panel™ contains the same components as the Postmenopause Panel™ but sampled twice, 13-15 days apart. (acpm.net)
  • The inclusion of FSH and LH in the expanded Postmenopause Panel™ (ePostM™) and expanded Perimenopause Panel™ (ePeriM™), extends the interpretation to include pituitary involvement. (acpm.net)
  • Doctors have identified three stages of menopause: perimenopause, menopause, and postmenopause. (medicalnewstoday.com)
  • Once you have passed through perimenopause and menopause you will enter the stage called postmenopause. (menopausewoman.co.uk)
  • Aside from menstruation changes, the symptoms of perimenopause, menopause, and postmenopause are generally the same. (healthline.com)
  • For women who experience it naturally (not as the result of surgery or other causes), menopause has three distinct stages: perimenopause, menopause and postmenopause. (besthealthmag.ca)
  • To balance your hormones, natural progesterone is what you need to safely reduce or eliminate postmenopause symptoms. (safemenopausesolutions.com)
  • Natural hormones are safer, more effective and have greater protective benefits.Postmenopause women also have the option to use natural progesterone cream and phytoestrogen together in the same product. (safemenopausesolutions.com)
  • Early postmenopause women can benefit from hormone therapy Hormone therapy usually involves a combination of both estrogens (the main female hormones) and progestins (other important female hormones). (thecalifornian.com)
  • Hormones like estrogen, progesterone and testosterone decline naturally, leading to imbalanced levels and many uncomfortable symptoms of postmenopause. (menopausecentre.com.au)
  • Since hormones play an important part in women's bodies, it is important to understand the connection between postmenopause and hormones. (menopausenow.com)
  • Hormones both cause the symptoms associated with postmenopause and can help alleviate them, since the levels of hormones is key. (menopausenow.com)
  • Levels of primary sex hormones generally reach consistently lower levels in postmenopause than in premenopause. (menopausenow.com)
  • We will provide you with your levels of each of the 2 hormones measured in our Women's Postmenopause test. (everlywell.com)
  • This hormone test checks for hormone imbalance in estradiol and progesterone levels, two sex hormones whose levels decline with postmenopause and can play a role in the symptoms some women experience. (everlywell.com)
  • Additionally, women face a number of health risks in postmenopause due to the drop in hormones that play such critical functions for underlying health. (bodylogicmd.com)
  • Many women appreciate finishing up menopause and entering postmenopause because their menopausal symptoms usually subside, but some women are still at risk for ovarian cysts, which can lead to ovarian cancer. (34-menopause-symptoms.com)
  • The time of a woman's life following menopause is called postmenopause. (patientslikeme.com)
  • The official definition of postmenopause is a permanent state of infertility that lasts for the rest of a woman's life, beginning 12 months after her final period. (menopausewoman.co.uk)
  • Postmenopause is the stage of a woman's life that follows menopause. (balancehormoneoklahoma.com)
  • Of course, there is not a hard "cutoff," so it can be difficult to determine exactly where a particular woman's menopause ends and postmenopause begins. (balancehormoneoklahoma.com)
  • The integrative functioning of the hypothalamic-pituitary-adrenal (HPA) and the hypothalamic-pituitary-ovarian (HPO) axes is well established, but to date there is limited understanding of the HPA axis functioning during the menopausal transition (MT) and early postmenopause (PM), a time of change in HPO function. (pubmedcentralcanada.ca)
  • For example, postmenopause and libido issues, heart disease, strokes, arthritis and osteoporosis can all become major health issues. (safemenopausesolutions.com)
  • to evaluate urinary desoxypiridinoline (Dpd) levels in postmenopause patients, with osteoporosis or osteopenia after treatment with sodium alendronate. (medigraphic.com)
  • Osteoporosis en la mujer posmenop usica mexicana. (medigraphic.com)
  • Orozco J, Morales G, Elizondo J. Estudio multic ntrico prevalencia de osteoporosis en M xico. (medigraphic.com)
  • What is the importance of postmenopause and estrogen and progesterone. (safemenopausesolutions.com)
  • For a woman concerned about postmenopause and estrogen, her estrogen production drops to 40 or 60 percent of what it once was before menopause. (safemenopausesolutions.com)
  • During postmenopause, estrogen production drops, but it can still be 40-60% of what it was before menopause. (safemenopausesolutions.com)
  • It is possible that fluctuating estrogen production levels in the body lead to a temporary estrogen deficiency that causes postmenopause symptoms such as hot flashes, night sweats, vaginal dryness, urinary tract infections and memory loss. (safemenopausesolutions.com)
  • A decrease in estrogen levels is often the cause of postmenopause symptoms. (menopausenow.com)
  • To avoid uncomfortable postmenopause symptoms, progesterone and estrogen should be balanced . (menopausenow.com)
  • Postmenopause is the stage of life when for more than 12 consecutive months, your menstrual periods have completely stopped. (safemenopausesolutions.com)
  • Although a natural event, the transition from regular cycling to the final menstrual period (FMP) and beyond into postmenopause is commonly accompanied by physiological and/or psychological symptoms. (thefreedictionary.com)
  • A subset of Seattle Midlife Women's Health Study participants who provided data during the late reproductive, early and late MT stages or early postmenopause (PM) and who were not using hormone therapy or corticosteroids (N=132 women, up to 5218 observations) including menstrual calendars for staging the MT, annual health reports, health diaries, and overnight urine specimens (assayed for cortisol, catecholamines, estrone glucuronide and FSH) between 1990 and 2005 were included. (pubmedcentralcanada.ca)
  • During postmenopause, hormonal fluctuations might still occur within women´s bodies, sometimes prolonging symptoms. (menopausecentre.com.au)
  • Hormonal Causes of Post Menopause The same hormonal fluctuations that triggered the menopause process also play an important role during postmenopause. (menopausecentre.com.au)
  • Hormonal changes associated with postmenopause are what causes uncomfortable symptoms that many women experience. (menopausenow.com)
  • There comes a time when the hormonal transition settles and she faces the postmenopause phase . (bodylogicmd.com)
  • Data from patients with postmenopause, who reported starting treatments within the last 5 years. (patientslikeme.com)
  • If you want to learn more about postmenopause , click on the link below to find out about postmenopause treatments. (34-menopause-symptoms.com)
  • Let's talk about how hormone therapy, dietary changes, and other treatments can help alleviate the symptoms of postmenopause and free you to enjoy your golden years. (balancehormoneoklahoma.com)
  • Maturitas: Journal of the Climacteric & Postmenopause , 26, 83-95. (thefreedictionary.com)
  • The climacteric symptoms during peri- and postmenopause have not been extensively studied in China. (nih.gov)
  • Progesterone plays an especially important role in ovulation , but once a woman is no longer ovulating, as is the case during postmenopause, progesterone levels drop to almost zero. (menopausenow.com)
  • Sometimes, women who experience constant periods of stress -due to financial hardships or familial disputes, for instance- may undergo the transition to postmenopause early. (menopausecentre.com.au)
  • Does Risk of Ovarian Cancer Increase during Postmenopause? (34-menopause-symptoms.com)
  • Although the increased risk of ovarian cancer is one that is particularly well known to affect women during menopause and postmenopause, it should also be remembered that your risk of contracting any cancer increases with age . (34-menopause-symptoms.com)
  • Continue reading to find out what ovarian cancer is, what the signs are, and why it is thought that the risk of ovarian cancer increases throughout postmenopause . (34-menopause-symptoms.com)
  • Although this article lists the wide range of serious health risks of smoking to women in menopause and postmenopause (see pg. (thefreedictionary.com)
  • Improving the amount of nutrition in your diet will provide many benefits, and will help to reduce health risks that you may face postmenopause. (menopausecentre.com.au)
  • Breast pain , whether severe or mild, is a common symptom during postmenopause that can be very irritating. (menopausenow.com)
  • Gait variability detects women in early postmenopause with low bone mineral density. (thefreedictionary.com)
  • Menopause and postmenopause can be alarming for women who don't know what to expect. (34-menopause-symptoms.com)
  • Over 600 women were divided into two groups: those less than six years past menopause (called the "early postmenopause" group) and those 10 years or more past menopause (the "late postmenopause" group). (thecalifornian.com)
  • When women reach postmenopause, they will regain a sense of control of their bodies. (menopausecentre.com.au)
  • Commonly, most women reach Postmenopause during their late 40s to their 60s. (menopausecentre.com.au)
  • In the United States, the average age for women to reach postmenopause is the early fifties. (menopausecentre.com.au)
  • Women who have both ovaries removed, due to cancer or other health concerns, will be flung into menopause and Postmenopause immediately after the surgery, causing them to suffer the consequences of sudden hormone depletion. (menopausecentre.com.au)
  • Postmenopause is the third and final stage and means "after the end of menstruation" . (replens.com)
  • How much postmenopause weight gain can be blamed on weight-promoting medications? (brightsurf.com)
  • CLEVELAND, Ohio (July 15, 2020)--Abdominal weight gain, which is common during the postmenopause period, is associated with an array of health problems, including diabetes and heart disease. (brightsurf.com)
  • Our Postmenopause test can help you answer questions about your hormone levels. (everlywell.com)
  • Our women's Postmenopause test is collected in your own home and results are provided by an experienced, CLIA-certified laboratory so you can check in on your body's hormone levels to see if there is a potential hormone imbalance that could be contributing to your symptoms. (everlywell.com)
  • In the early postmenopause group, HT slowed the development of atherosclerosis. (thecalifornian.com)
  • Although these fluctuations are more severe during the years leading up to menopause, they might continue in the early postmenopause years. (menopausecentre.com.au)
  • This article will provide an explanation of some of the key changes that your body may experience during this phase, and offers suggestions for ways in which you can look after your health postmenopause. (menopausecentre.com.au)
  • Even though hormone changes are at the very foundation of postmenopause there are a number of external factors that could throw a woman into her postmenopause years earlier in her life. (menopausecentre.com.au)
  • But what you may not know is that the first three to five years postmenopause are the most crucial for bones. (thefreedictionary.com)
  • n=88), who were between six months and three years postmenopause , were treated for up to three years. (thefreedictionary.com)
  • Postmenopause refers to the years after menopause has occurred. (healthline.com)
  • To determine the effectiveness of using the medicinal form of the complex preparation Polygynax Virgo in treatment and prevention of vulvovaginal infections in postmenopause. (med-expert.com.ua)
  • Polygynax is highly effective in treatment of nonspecific colpitis in postmenopause. (med-expert.com.ua)
  • Postmenopause can come across as an enigmatic time of life -the first time in decades that a woman does not have the capacity to reproduce. (menopausecentre.com.au)
  • Check out the following link to learn more about the different symptoms of postmenopause . (menopausenow.com)
  • Learn more about how to treat breast pain during postmenopause . (menopausenow.com)
  • The final stop along our midlife tour is postmenopause. (menopause.org)