The physiological period following the MENOPAUSE, the permanent cessation of the menstrual life.
Metabolic disorder associated with fractures of the femoral neck, vertebrae, and distal forearm. It occurs commonly in women within 15-20 years after menopause, and is caused by factors associated with menopause including estrogen deficiency.
The use of hormonal agents with estrogen-like activity in postmenopausal or other estrogen-deficient women to alleviate effects of hormone deficiency, such as vasomotor symptoms, DYSPAREUNIA, and progressive development of OSTEOPOROSIS. This may also include the use of progestational agents in combination therapy.
The last menstrual period. Permanent cessation of menses (MENSTRUATION) is usually defined after 6 to 12 months of AMENORRHEA in a woman over 45 years of age. In the United States, menopause generally occurs in women between 48 and 55 years of age.
A pharmaceutical preparation containing a mixture of water-soluble, conjugated estrogens derived wholly or in part from URINE of pregnant mares or synthetically from ESTRONE and EQUILIN. It contains a sodium-salt mixture of estrone sulfate (52-62%) and equilin sulfate (22-30%) with a total of the two between 80-88%. Other concomitant conjugates include 17-alpha-dihydroequilin, 17-alpha-estradiol, and 17-beta-dihydroequilin. The potency of the preparation is expressed in terms of an equivalent quantity of sodium estrone sulfate.
The amount of mineral per square centimeter of BONE. This is the definition used in clinical practice. Actual bone density would be expressed in grams per milliliter. It is most frequently measured by X-RAY ABSORPTIOMETRY or TOMOGRAPHY, X RAY COMPUTED. Bone density is an important predictor for OSTEOPOROSIS.
Compounds that interact with ESTROGEN RECEPTORS in target tissues to bring about the effects similar to those of ESTRADIOL. Estrogens stimulate the female reproductive organs, and the development of secondary female SEX CHARACTERISTICS. Estrogenic chemicals include natural, synthetic, steroidal, or non-steroidal compounds.
The period before MENOPAUSE. In premenopausal women, the climacteric transition from full sexual maturity to cessation of ovarian cycle takes place between the age of late thirty and early fifty.
The concept covering the physical and mental conditions of women.
Tumors or cancer of the human BREAST.
Compounds that inhibit AROMATASE in order to reduce production of estrogenic steroid hormones.
The 17-beta-isomer of estradiol, an aromatized C18 steroid with hydroxyl group at 3-beta- and 17-beta-position. Estradiol-17-beta is the most potent form of mammalian estrogenic steroids.
Therapeutic use of hormones to alleviate the effects of hormone deficiency.
An aromatized C18 steroid with a 3-hydroxyl group and a 17-ketone, a major mammalian estrogen. It is converted from ANDROSTENEDIONE directly, or from TESTOSTERONE via ESTRADIOL. In humans, it is produced primarily by the cyclic ovaries, PLACENTA, and the ADIPOSE TISSUE of men and postmenopausal women.
Agents that inhibit BONE RESORPTION and/or favor BONE MINERALIZATION and BONE REGENERATION. They are used to heal BONE FRACTURES and to treat METABOLIC BONE DISEASES such as OSTEOPOROSIS.
A glycoprotein migrating as a beta-globulin. Its molecular weight, 52,000 or 95,000-115,000, indicates that it exists as a dimer. The protein binds testosterone, dihydrotestosterone, and estradiol in the plasma. Sex hormone-binding protein has the same amino acid sequence as ANDROGEN-BINDING PROTEIN. They differ by their sites of synthesis and post-translational oligosaccharide modifications.
An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.
One of the SELECTIVE ESTROGEN RECEPTOR MODULATORS with tissue-specific activities. Tamoxifen acts as an anti-estrogen (inhibiting agent) in the mammary tissue, but as an estrogen (stimulating agent) in cholesterol metabolism, bone density, and cell proliferation in the ENDOMETRIUM.
Organic compounds containing the -CN radical. The concept is distinguished from CYANIDES, which denotes inorganic salts of HYDROGEN CYANIDE.
3-Phenylchromones. Isomeric form of FLAVONOIDS in which the benzene group is attached to the 3 position of the benzopyran ring instead of the 2 position.
A synthetic progestin that is derived from 17-hydroxyprogesterone. It is a long-acting contraceptive that is effective both orally or by intramuscular injection and has also been used to treat breast and endometrial neoplasms.
A method of studying a drug or procedure in which both the subjects and investigators are kept unaware of who is actually getting which specific treatment.
A second generation selective estrogen receptor modulator (SERM) used to prevent osteoporosis in postmenopausal women. It has estrogen agonist effects on bone and cholesterol metabolism but behaves as a complete estrogen antagonist on mammary gland and uterine tissue.
Human females as cultural, psychological, sociological, political, and economic entities.
Antineoplastic agents that are used to treat hormone-sensitive tumors. Hormone-sensitive tumors may be hormone-dependent, hormone-responsive, or both. A hormone-dependent tumor regresses on removal of the hormonal stimulus, by surgery or pharmacological block. Hormone-responsive tumors may regress when pharmacologic amounts of hormones are administered regardless of whether previous signs of hormone sensitivity were observed. The major hormone-responsive cancers include carcinomas of the breast, prostate, and endometrium; lymphomas; and certain leukemias. (From AMA Drug Evaluations Annual 1994, p2079)
Compounds that interact with PROGESTERONE RECEPTORS in target tissues to bring about the effects similar to those of PROGESTERONE. Primary actions of progestins, including natural and synthetic steroids, are on the UTERUS and the MAMMARY GLAND in preparation for and in maintenance of PREGNANCY.
Steroid hormones produced by the GONADS. They stimulate reproductive organs, germ cell maturation, and the secondary sex characteristics in the males and the females. The major sex steroid hormones include ESTRADIOL; PROGESTERONE; and TESTOSTERONE.
Physiologic period, characterized by endocrine, somatic, and psychic changes with the termination of ovarian function in the female. It may also accompany the normal diminution of sexual activity in the male.
(6 alpha)-17-Hydroxy-6-methylpregn-4-ene-3,20-dione. A synthetic progestational hormone used in veterinary practice as an estrus regulator.
A sudden, temporary sensation of heat predominantly experienced by some women during MENOPAUSE. (Random House Unabridged Dictionary, 2d ed)
A noninvasive method for assessing BODY COMPOSITION. It is based on the differential absorption of X-RAYS (or GAMMA RAYS) by different tissues such as bone, fat and other soft tissues. The source of (X-ray or gamma-ray) photon beam is generated either from radioisotopes such as GADOLINIUM 153, IODINE 125, or Americanium 241 which emit GAMMA RAYS in the appropriate range; or from an X-ray tube which produces X-RAYS in the desired range. It is primarily used for quantitating BONE MINERAL CONTENT, especially for the diagnosis of OSTEOPOROSIS, and also in measuring BONE MINERALIZATION.
Breaks in bones.
Pregnenes with one double bond or more than three double bonds which have undergone ring contractions or are lacking carbon-18 or carbon-19..
Reduction of bone mass without alteration in the composition of bone, leading to fractures. Primary osteoporosis can be of two major types: postmenopausal osteoporosis (OSTEOPOROSIS, POSTMENOPAUSAL) and age-related or senile osteoporosis.
Studies which start with the identification of persons with a disease of interest and a control (comparison, referent) group without the disease. The relationship of an attribute to the disease is examined by comparing diseased and non-diseased persons with regard to the frequency or levels of the attribute in each group.
The transitional period before and after MENOPAUSE. Perimenopausal symptoms are associated with irregular MENSTRUAL CYCLE and widely fluctuated hormone levels. They may appear 6 years before menopause and subside 2 to 5 years after menopause.
A structurally diverse group of compounds distinguished from ESTROGENS by their ability to bind and activate ESTROGEN RECEPTORS but act as either an agonist or antagonist depending on the tissue type and hormonal milieu. They are classified as either first generation because they demonstrate estrogen agonist properties in the ENDOMETRIUM or second generation based on their patterns of tissue specificity. (Horm Res 1997;48:155-63)
Proteins which are present in or isolated from SOYBEANS.
A nonhormonal medication for the treatment of postmenopausal osteoporosis in women. This drug builds healthy bone, restoring some of the bone loss as a result of osteoporosis.
An indicator of body density as determined by the relationship of BODY WEIGHT to BODY HEIGHT. BMI=weight (kg)/height squared (m2). BMI correlates with body fat (ADIPOSE TISSUE). Their relationship varies with age and gender. For adults, BMI falls into these categories: below 18.5 (underweight); 18.5-24.9 (normal); 25.0-29.9 (overweight); 30.0 and above (obese). (National Center for Health Statistics, Centers for Disease Control and Prevention)
PLANT EXTRACTS and compounds, primarily ISOFLAVONES, that mimic or modulate endogenous estrogens, usually by binding to ESTROGEN RECEPTORS.
A synthetic progestational hormone with actions similar to those of PROGESTERONE but functioning as a more potent inhibitor of ovulation. It has weak estrogenic and androgenic properties. The hormone has been used in treating amenorrhea, functional uterine bleeding, endometriosis, and for contraception.
Cytoplasmic proteins that bind estrogens and migrate to the nucleus where they regulate DNA transcription. Evaluation of the state of estrogen receptors in breast cancer patients has become clinically important.
Studies in which subsets of a defined population are identified. These groups may or may not be exposed to factors hypothesized to influence the probability of the occurrence of a particular disease or other outcome. Cohorts are defined populations which, as a whole, are followed in an attempt to determine distinguishing subgroup characteristics.
The constricted portion of the thigh bone between the femur head and the trochanters.
The application of suitable drug dosage forms to the skin for either local or systemic effects.
Steroidal compounds related to PROGESTERONE, the major mammalian progestational hormone. Progesterone congeners include important progesterone precursors in the biosynthetic pathways, metabolites, derivatives, and synthetic steroids with progestational activities.
The circulating form of a major C19 steroid produced primarily by the ADRENAL CORTEX. DHEA sulfate serves as a precursor for TESTOSTERONE; ANDROSTENEDIONE; ESTRADIOL; and ESTRONE.
Studies comparing two or more treatments or interventions in which the subjects or patients, upon completion of the course of one treatment, are switched to another. In the case of two treatments, A and B, half the subjects are randomly allocated to receive these in the order A, B and half to receive them in the order B, A. A criticism of this design is that effects of the first treatment may carry over into the period when the second is given. (Last, A Dictionary of Epidemiology, 2d ed)
Tumors or cancer of ENDOMETRIUM, the mucous lining of the UTERUS. These neoplasms can be benign or malignant. Their classification and grading are based on the various cell types and the percent of undifferentiated cells.
Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.
Any dummy medication or treatment. Although placebos originally were medicinal preparations having no specific pharmacological activity against a targeted condition, the concept has been extended to include treatments or procedures, especially those administered to control groups in clinical trials in order to provide baseline measurements for the experimental protocol.
A specialized CONNECTIVE TISSUE that is the main constituent of the SKELETON. The principle cellular component of bone is comprised of OSTEOBLASTS; OSTEOCYTES; and OSTEOCLASTS, while FIBRILLAR COLLAGENS and hydroxyapatite crystals form the BONE MATRIX.
Bleeding from blood vessels in the UTERUS, sometimes manifested as vaginal bleeding.
A diphosphonate which affects calcium metabolism. It inhibits ectopic calcification and slows down bone resorption and bone turnover.
Studies in which the presence or absence of disease or other health-related variables are determined in each member of the study population or in a representative sample at one particular time. This contrasts with LONGITUDINAL STUDIES which are followed over a period of time.
A potent androgenic steroid and major product secreted by the LEYDIG CELLS of the TESTIS. Its production is stimulated by LUTEINIZING HORMONE from the PITUITARY GLAND. In turn, testosterone exerts feedback control of the pituitary LH and FSH secretion. Depending on the tissues, testosterone can be further converted to DIHYDROTESTOSTERONE or ESTRADIOL.
A polypeptide that consists of the 1-34 amino-acid fragment of human PARATHYROID HORMONE, the biologically active N-terminal region. The acetate form is given by intravenous infusion in the differential diagnosis of HYPOPARATHYROIDISM and PSEUDOHYPOPARATHYROIDISM. (Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Englewood, CO, 1995)
Age as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or the effect of a circumstance. It is used with human or animal concepts but should be differentiated from AGING, a physiological process, and TIME FACTORS which refers only to the passage of time.
The surgical removal of one or both ovaries.
Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.
Regular course of eating and drinking adopted by a person or animal.
Breaks in bones resulting from low bone mass and microarchitectural deterioration characteristic of OSTEOPOROSIS.
The number of new cases of a given disease during a given period in a specified population. It also is used for the rate at which new events occur in a defined population. It is differentiated from PREVALENCE, which refers to all cases, new or old, in the population at a given time.
Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.
The probability that an event will occur. It encompasses a variety of measures of the probability of a generally unfavorable outcome.
A status with BODY WEIGHT that is grossly above the acceptable or desirable weight, usually due to accumulation of excess FATS in the body. The standards may vary with age, sex, genetic or cultural background. In the BODY MASS INDEX, a BMI greater than 30.0 kg/m2 is considered obese, and a BMI greater than 40.0 kg/m2 is considered morbidly obese (MORBID OBESITY).
Predetermined sets of questions used to collect data - clinical data, social status, occupational group, etc. The term is often applied to a self-completed survey instrument.
A non-steroidal ESTROGEN generated when soybean products are metabolized by certain bacteria in the intestines.
Broken bones in the vertebral column.
Foods made from SOYBEANS. Health benefits are ascribed to the high levels of DIETARY PROTEINS and ISOFLAVONES.
Compounds which inhibit or antagonize the action or biosynthesis of estrogenic compounds.
A delta-4 C19 steroid that is produced not only in the TESTIS, but also in the OVARY and the ADRENAL CORTEX. Depending on the tissue type, androstenedione can serve as a precursor to TESTOSTERONE as well as ESTRONE and ESTRADIOL.
Products in capsule, tablet or liquid form that provide dietary ingredients, and that are intended to be taken by mouth to increase the intake of nutrients. Dietary supplements can include macronutrients, such as proteins, carbohydrates, and fats; and/or MICRONUTRIENTS, such as VITAMINS; MINERALS; and PHYTOCHEMICALS.
Calcium compounds used as food supplements or in food to supply the body with calcium. Dietary calcium is needed during growth for bone development and for maintenance of skeletal integrity later in life to prevent osteoporosis.
Benign proliferation of the ENDOMETRIUM in the UTERUS. Endometrial hyperplasia is classified by its cytology and glandular tissue. There are simple, complex (adenomatous without atypia), and atypical hyperplasia representing also the ascending risk of becoming malignant.
Substances that possess antiestrogenic actions but can also produce estrogenic effects as well. They act as complete or partial agonist or as antagonist. They can be either steroidal or nonsteroidal in structure.
A major C19 steroid produced by the ADRENAL CORTEX. It is also produced in small quantities in the TESTIS and the OVARY. Dehydroepiandrosterone (DHEA) can be converted to TESTOSTERONE; ANDROSTENEDIONE; ESTRADIOL; and ESTRONE. Most of DHEA is sulfated (DEHYDROEPIANDROSTERONE SULFATE) before secretion.
The outer shorter of the two bones of the FOREARM, lying parallel to the ULNA and partially revolving around it.
VERTEBRAE in the region of the lower BACK below the THORACIC VERTEBRAE and above the SACRAL VERTEBRAE.
The genital canal in the female, extending from the UTERUS to the VULVA. (Stedman, 25th ed)
Radiographic examination of the breast.
Bone loss due to osteoclastic activity.
The qualitative or quantitative estimation of the likelihood of adverse effects that may result from exposure to specified health hazards or from the absence of beneficial influences. (Last, Dictionary of Epidemiology, 1988)
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
The mucous membrane lining of the uterine cavity that is hormonally responsive during the MENSTRUAL CYCLE and PREGNANCY. The endometrium undergoes cyclic changes that characterize MENSTRUATION. After successful FERTILIZATION, it serves to sustain the developing embryo.
Specific proteins found in or on cells of progesterone target tissues that specifically combine with progesterone. The cytosol progesterone-receptor complex then associates with the nucleic acids to initiate protein synthesis. There are two kinds of progesterone receptors, A and B. Both are induced by estrogen and have short half-lives.
A vitamin that includes both CHOLECALCIFEROLS and ERGOCALCIFEROLS, which have the common effect of preventing or curing RICKETS in animals. It can also be viewed as a hormone since it can be formed in SKIN by action of ULTRAVIOLET RAYS upon the precursors, 7-dehydrocholesterol and ERGOSTEROL, and acts on VITAMIN D RECEPTORS to regulate CALCIUM in opposition to PARATHYROID HORMONE.
Excision of the uterus.
The continuous turnover of BONE MATRIX and mineral that involves first an increase in BONE RESORPTION (osteoclastic activity) and later, reactive BONE FORMATION (osteoblastic activity). The process of bone remodeling takes place in the adult skeleton at discrete foci. The process ensures the mechanical integrity of the skeleton throughout life and plays an important role in calcium HOMEOSTASIS. An imbalance in the regulation of bone remodeling's two contrasting events, bone resorption and bone formation, results in many of the metabolic bone diseases, such as OSTEOPOROSIS.
Estrone derivatives substituted with one or more hydroxyl groups in any position. They are important metabolites of estrone and other estrogens.
Certain tumors that 1, arise in organs that are normally dependent on specific hormones and 2, are stimulated or caused to regress by manipulation of the endocrine environment.
Organic compounds which contain P-C-P bonds, where P stands for phosphonates or phosphonic acids. These compounds affect calcium metabolism. They inhibit ectopic calcification and slow down bone resorption and bone turnover. Technetium complexes of diphosphonates have been used successfully as bone scanning agents.
Elements of limited time intervals, contributing to particular results or situations.
In humans, one of the paired regions in the anterior portion of the THORAX. The breasts consist of the MAMMARY GLANDS, the SKIN, the MUSCLES, the ADIPOSE TISSUE, and the CONNECTIVE TISSUES.
A generic term for fats and lipoids, the alcohol-ether-soluble constituents of protoplasm, which are insoluble in water. They comprise the fats, fatty oils, essential oils, waxes, phospholipids, glycolipids, sulfolipids, aminolipids, chromolipids (lipochromes), and fatty acids. (Grant & Hackh's Chemical Dictionary, 5th ed)
The relative amounts of various components in the body, such as percentage of body fat.
The ratio of two odds. The exposure-odds ratio for case control data is the ratio of the odds in favor of exposure among cases to the odds in favor of exposure among noncases. The disease-odds ratio for a cohort or cross section is the ratio of the odds in favor of disease among the exposed to the odds in favor of disease among the unexposed. The prevalence-odds ratio refers to an odds ratio derived cross-sectionally from studies of prevalent cases.
The giving of drugs, chemicals, or other substances by mouth.
Statistical models which describe the relationship between a qualitative dependent variable (that is, one which can take only certain discrete values, such as the presence or absence of a disease) and an independent variable. A common application is in epidemiology for estimating an individual's risk (probability of a disease) as a function of a given risk factor.
Vitamin K-dependent calcium-binding protein synthesized by OSTEOBLASTS and found primarily in BONES. Serum osteocalcin measurements provide a noninvasive specific marker of bone metabolism. The protein contains three residues of the amino acid gamma-carboxyglutamic acid (Gla), which, in the presence of CALCIUM, promotes binding to HYDROXYAPATITE and subsequent accumulation in BONE MATRIX.
An enzyme that catalyzes the desaturation (aromatization) of the ring A of C19 androgens and converts them to C18 estrogens. In this process, the 19-methyl is removed. This enzyme is membrane-bound, located in the endoplasmic reticulum of estrogen-producing cells of ovaries, placenta, testes, adipose, and brain tissues. Aromatase is encoded by the CYP19 gene, and functions in complex with NADPH-FERRIHEMOPROTEIN REDUCTASE in the cytochrome P-450 system.
Statistical models used in survival analysis that assert that the effect of the study factors on the hazard rate in the study population is multiplicative and does not change over time.
Physical activity which is usually regular and done with the intention of improving or maintaining PHYSICAL FITNESS or HEALTH. Contrast with PHYSICAL EXERTION which is concerned largely with the physiologic and metabolic response to energy expenditure.
6,17-Dimethylpregna-4,6-diene-3,20-dione. A synthetic progestational hormone with actions similar to those of progesterone. It is used in the treatment of menstrual irregularities and has also been employed in the treatment of prostatic hypertrophy and endometrial carcinoma.
The range or frequency distribution of a measurement in a population (of organisms, organs or things) that has not been selected for the presence of disease or abnormality.
Drug therapy given to augment or stimulate some other form of treatment such as surgery or radiation therapy. Adjuvant chemotherapy is commonly used in the therapy of cancer and can be administered before or after the primary treatment.
The number of offspring a female has borne. It is contrasted with GRAVIDITY, which refers to the number of pregnancies, regardless of outcome.
Pathological conditions involving the CARDIOVASCULAR SYSTEM including the HEART; the BLOOD VESSELS; or the PERICARDIUM.
A range of values for a variable of interest, e.g., a rate, constructed so that this range has a specified probability of including the true value of the variable.
Material prepared from plants.
Statistical models in which the value of a parameter for a given value of a factor is assumed to be equal to a + bx, where a and b are constants. The models predict a linear regression.
The technique that deals with the measurement of the size, weight, and proportions of the human or other primate body.
Fractures of the FEMUR HEAD; the FEMUR NECK; (FEMORAL NECK FRACTURES); the trochanters; or the inter- or subtrochanteric region. Excludes fractures of the acetabulum and fractures of the femoral shaft below the subtrochanteric region (FEMORAL FRACTURES).
A statistical technique that isolates and assesses the contributions of categorical independent variables to variation in the mean of a continuous dependent variable.
A major gonadotropin secreted by the adenohypophysis (PITUITARY GLAND, ANTERIOR). Follicle-stimulating hormone stimulates GAMETOGENESIS and the supporting cells such as the ovarian GRANULOSA CELLS, the testicular SERTOLI CELLS, and LEYDIG CELLS. FSH consists of two noncovalently linked subunits, alpha and beta. Within a species, the alpha subunit is common in the three pituitary glycoprotein hormones (TSH, LH, and FSH), but the beta subunit is unique and confers its biological specificity.
A hydroxylated metabolite of ESTRADIOL or ESTRONE that has a hydroxyl group at C3, 16-alpha, and 17-beta position. Estriol is a major urinary estrogen. During PREGNANCY, a large amount of estriol is produced by the PLACENTA. Isomers with inversion of the hydroxyl group or groups are called epiestriol.
An important aggregate factor in epidemiological studies of women's health. The concept usually includes the number and timing of pregnancies and their outcomes, the incidence of breast feeding, and may include age of menarche and menopause, regularity of menstruation, fertility, gynecological or obstetric problems, or contraceptive usage.
The spinal or vertebral column.
The major progestational steroid that is secreted primarily by the CORPUS LUTEUM and the PLACENTA. Progesterone acts on the UTERUS, the MAMMARY GLANDS and the BRAIN. It is required in EMBRYO IMPLANTATION; PREGNANCY maintenance, and the development of mammary tissue for MILK production. Progesterone, converted from PREGNENOLONE, also serves as an intermediate in the biosynthesis of GONADAL STEROID HORMONES and adrenal CORTICOSTEROIDS.
Procedures for finding the mathematical function which best describes the relationship between a dependent variable and one or more independent variables. In linear regression (see LINEAR MODELS) the relationship is constrained to be a straight line and LEAST-SQUARES ANALYSIS is used to determine the best fit. In logistic regression (see LOGISTIC MODELS) the dependent variable is qualitative rather than continuously variable and LIKELIHOOD FUNCTIONS are used to find the best relationship. In multiple regression, the dependent variable is considered to depend on more than a single independent variable.
Cholesterol which is contained in or bound to high-density lipoproteins (HDL), including CHOLESTEROL ESTERS and free cholesterol.
Human females who are pregnant, as cultural, psychological, or sociological entities.
Compounds that interact with ANDROGEN RECEPTORS in target tissues to bring about the effects similar to those of TESTOSTERONE. Depending on the target tissues, androgenic effects can be on SEX DIFFERENTIATION; male reproductive organs, SPERMATOGENESIS; secondary male SEX CHARACTERISTICS; LIBIDO; development of muscle mass, strength, and power.
Studies in which variables relating to an individual or group of individuals are assessed over a period of time.
Works about clinical trials that involve at least one test treatment and one control treatment, concurrent enrollment and follow-up of the test- and control-treated groups, and in which the treatments to be administered are selected by a random process, such as the use of a random-numbers table.
An aromatase inhibitor that is used in the treatment of advanced BREAST CANCER.
The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.
Derivatives of the steroid androstane having two double bonds at any site in any of the rings.
Maleness or femaleness as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or effect of a circumstance. It is used with human or animal concepts but should be differentiated from SEX CHARACTERISTICS, anatomical or physiological manifestations of sex, and from SEX DISTRIBUTION, the number of males and females in given circumstances.
The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.
A class of dibenzylbutane derivatives which occurs in higher plants and in fluids (bile, serum, urine, etc.) in man and other animals. These compounds, which have a potential anti-cancer role, can be synthesized in vitro by human fecal flora. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)
Time schedule for administration of a drug in order to achieve optimum effectiveness and convenience.
Women who are physically and mentally abused over an extended period, usually by a husband or other dominant male figure. Characteristics of the battered woman syndrome are helplessness, constant fear, and a perceived inability to escape. (From American Heritage Dictionary of the English Language, 3d ed)
The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
Endoscopic examination, therapy or surgery of the interior of the uterus.
The most common form of fibrillar collagen. It is a major constituent of bone (BONE AND BONES) and SKIN and consists of a heterotrimer of two alpha1(I) and one alpha2(I) chains.
A synthetic progestational hormone with no androgenic or estrogenic properties. Unlike many other progestational compounds, dydrogesterone produces no increase in temperature and does not inhibit OVULATION.
Cholesterol which is contained in or bound to low density lipoproteins (LDL), including CHOLESTEROL ESTERS and free cholesterol.
The largest of the TARSAL BONES which is situated at the lower and back part of the FOOT, forming the HEEL.
The projecting part on each side of the body, formed by the side of the pelvis and the top portion of the femur.
Decrease in existing BODY WEIGHT.
A selective aromatase inhibitor effective in the treatment of estrogen-dependent disease including breast cancer.
The periodic shedding of the ENDOMETRIUM and associated menstrual bleeding in the MENSTRUAL CYCLE of humans and primates. Menstruation is due to the decline in circulating PROGESTERONE, and occurs at the late LUTEAL PHASE when LUTEOLYSIS of the CORPUS LUTEUM takes place.
A polypeptide hormone (84 amino acid residues) secreted by the PARATHYROID GLANDS which performs the essential role of maintaining intracellular CALCIUM levels in the body. Parathyroid hormone increases intracellular calcium by promoting the release of CALCIUM from BONE, increases the intestinal absorption of calcium, increases the renal tubular reabsorption of calcium, and increases the renal excretion of phosphates.
Typical way of life or manner of living characteristic of an individual or group. (From APA, Thesaurus of Psychological Index Terms, 8th ed)
A diet designed to cause an individual to lose weight.
An annual legume. The SEEDS of this plant are edible and used to produce a variety of SOY FOODS.
One of the ESTROGEN RECEPTORS that has marked affinity for ESTRADIOL. Its expression and function differs from, and in some ways opposes, ESTROGEN RECEPTOR BETA.
Fractures occurring as a result of disease of a bone or from some undiscoverable cause, and not due to trauma. (Dorland, 27th ed)
A status with BODY WEIGHT that is above certain standard of acceptable or desirable weight. In the scale of BODY MASS INDEX, overweight is defined as having a BMI of 25.0-29.9 kg/m2. Overweight may or may not be due to increases in body fat (ADIPOSE TISSUE), hence overweight does not equal "over fat".
Chemical substances having a specific regulatory effect on the activity of a certain organ or organs. The term was originally applied to substances secreted by various ENDOCRINE GLANDS and transported in the bloodstream to the target organs. It is sometimes extended to include those substances that are not produced by the endocrine glands but that have similar effects.
Specialized connective tissue composed of fat cells (ADIPOCYTES). It is the site of stored FATS, usually in the form of TRIGLYCERIDES. In mammals, there are two types of adipose tissue, the WHITE FAT and the BROWN FAT. Their relative distributions vary in different species with most adipose tissue being white.
A plant genus of the family LINACEAE that is cultivated for its fiber (manufactured into linen cloth). It contains a trypsin inhibitor and the seed is the source of LINSEED OIL.
The amount of fat or lipid deposit at a site or an organ in the body, an indicator of body fat status.
Glucose in blood.
The regular and simultaneous occurrence in a single interbreeding population of two or more discontinuous genotypes. The concept includes differences in genotypes ranging in size from a single nucleotide site (POLYMORPHISM, SINGLE NUCLEOTIDE) to large nucleotide sequences visible at a chromosomal level.
Individuals whose ancestral origins are in the continent of Europe.
PRESSURE of the BLOOD on the ARTERIES and other BLOOD VESSELS.
Inhaling and exhaling the smoke of burning TOBACCO.
Megestrol acetate is a progestogen with actions and uses similar to those of the progestogens in general. It also has anti-androgenic properties. It is given by mouth in the palliative treatment or as an adjunct to other therapy in endometrial carcinoma and in breast cancer. Megestrol acetate has been approved to treat anorexia and cachexia. (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Englewood, CO, 1995)
A plasma protein that circulates in increased amounts during inflammation and after tissue damage.
The period from onset of one menstrual bleeding (MENSTRUATION) to the next in an ovulating woman or female primate. The menstrual cycle is regulated by endocrine interactions of the HYPOTHALAMUS; the PITUITARY GLAND; the ovaries; and the genital tract. The menstrual cycle is divided by OVULATION into two phases. Based on the endocrine status of the OVARY, there is a FOLLICULAR PHASE and a LUTEAL PHASE. Based on the response in the ENDOMETRIUM, the menstrual cycle is divided into a proliferative and a secretory phase.
Oral contraceptives which owe their effectiveness to hormonal preparations.
A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.
Behaviors associated with the ingesting of alcoholic beverages, including social drinking.
Therapy with two or more separate preparations given for a combined effect.
Organized periodic procedures performed on large groups of people for the purpose of detecting disease.
An imbalance between myocardial functional requirements and the capacity of the CORONARY VESSELS to supply sufficient blood flow. It is a form of MYOCARDIAL ISCHEMIA (insufficient blood supply to the heart muscle) caused by a decreased capacity of the coronary vessels.
Discrete abnormal tissue masses that protrude into the lumen of the DIGESTIVE TRACT or the RESPIRATORY TRACT. Polyps can be spheroidal, hemispheroidal, or irregular mound-shaped structures attached to the MUCOUS MEMBRANE of the lumen wall either by a stalk, pedunculus, or by a broad base.
Fatty tissue in the region of the ABDOMEN. It includes the ABDOMINAL SUBCUTANEOUS FAT and the INTRA-ABDOMINAL FAT.
Organized services to provide health care to women. It excludes maternal care services for which MATERNAL HEALTH SERVICES is available.
Compounds, usually hormonal, taken orally in order to block ovulation and prevent the occurrence of pregnancy. The hormones are generally estrogen or progesterone or both.
The 3-cyclopentyl ether of ETHINYL ESTRADIOL. After gastrointestinal absorption, it is stored in ADIPOSE TISSUE, slowly released, and metabolized principally to the parent compound. It has been used in ESTROGEN REPLACEMENT THERAPY. (From AMA Drug Evaluations Annual, 1992, p1011)
In screening and diagnostic tests, the probability that a person with a positive test is a true positive (i.e., has the disease), is referred to as the predictive value of a positive test; whereas, the predictive value of a negative test is the probability that the person with a negative test does not have the disease. Predictive value is related to the sensitivity and specificity of the test.
The principal sterol of all higher animals, distributed in body tissues, especially the brain and spinal cord, and in animal fats and oils.
An intermediate in TESTOSTERONE biosynthesis, found in the TESTIS or the ADRENAL GLANDS. Androstenediol, derived from DEHYDROEPIANDROSTERONE by the reduction of the 17-keto group (17-HYDROXYSTEROID DEHYDROGENASES), is converted to TESTOSTERONE by the oxidation of the 3-beta hydroxyl group to a 3-keto group (3-HYDROXYSTEROID DEHYDROGENASES).
Recurrent genital pain occurring during, before, or after SEXUAL INTERCOURSE in either the male or the female.
A first generation selective estrogen receptor modulator (SERM). Like TAMOXIFEN, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
An invasive (infiltrating) CARCINOMA of the mammary ductal system (MAMMARY GLANDS) in the human BREAST.
The insertion of drugs into the vagina to treat local infections, neoplasms, or to induce labor. The dosage forms may include medicated pessaries, irrigation fluids, and suppositories.
The relationship between the dose of an administered drug and the response of the organism to the drug.
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
The rights of women to equal status pertaining to social, economic, and educational opportunities afforded by society.
The first MENSTRUAL CYCLE marked by the initiation of MENSTRUATION.
A infiltrating (invasive) breast cancer, relatively uncommon, accounting for only 5%-10% of breast tumors in most series. It is often an area of ill-defined thickening in the breast, in contrast to the dominant lump characteristic of ductal carcinoma. It is typically composed of small cells in a linear arrangement with a tendency to grow around ducts and lobules. There is likelihood of axillary nodal involvement with metastasis to meningeal and serosal surfaces. (DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1205)
Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS.
Those characteristics that distinguish one SEX from the other. The primary sex characteristics are the OVARIES and TESTES and their related hormones. Secondary sex characteristics are those which are masculine or feminine but not directly related to reproduction.
Classic quantitative assay for detection of antigen-antibody reactions using a radioactively labeled substance (radioligand) either directly or indirectly to measure the binding of the unlabeled substance to a specific antibody or other receptor system. Non-immunogenic substances (e.g., haptens) can be measured if coupled to larger carrier proteins (e.g., bovine gamma-globulin or human serum albumin) capable of inducing antibody formation.
The ability to carry out daily tasks and perform physical activities in a highly functional state, often as a result of physical conditioning.
The frequency of different ages or age groups in a given population. The distribution may refer to either how many or what proportion of the group. The population is usually patients with a specific disease but the concept is not restricted to humans and is not restricted to medicine.
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
A plant genus of the family FABACEAE a common weed of the southeast US. There has been folk use for alcoholism and liver protection. It contains puerarin, kakkalide, daidzein (isoflavonoids), and kudzusaponins (oleanene-type triterpene glycosides).
A set of techniques used when variation in several variables has to be studied simultaneously. In statistics, multivariate analysis is interpreted as any analytic method that allows simultaneous study of two or more dependent variables.
A 51-amino acid pancreatic hormone that plays a major role in the regulation of glucose metabolism, directly by suppressing endogenous glucose production (GLYCOGENOLYSIS; GLUCONEOGENESIS) and indirectly by suppressing GLUCAGON secretion and LIPOLYSIS. Native insulin is a globular protein comprised of a zinc-coordinated hexamer. Each insulin monomer containing two chains, A (21 residues) and B (30 residues), linked by two disulfide bonds. Insulin is used as a drug to control insulin-dependent diabetes mellitus (DIABETES MELLITUS, TYPE 1).
A major gonadotropin secreted by the adenohypophysis (PITUITARY GLAND, ANTERIOR). Luteinizing hormone regulates steroid production by the interstitial cells of the TESTIS and the OVARY. The preovulatory LUTEINIZING HORMONE surge in females induces OVULATION, and subsequent LUTEINIZATION of the follicle. LUTEINIZING HORMONE consists of two noncovalently linked subunits, alpha and beta. Within a species, the alpha subunit is common in the three pituitary glycoprotein hormones (TSH, LH and FSH), but the beta subunit is unique and confers its biological specificity.
Postmenopausal women[edit]. Endometrial atrophy, uterine fibroids, and endometrial cancer are common causes of postmenopausal ... A cut-off threshold of 3 mm or less of endometrial thickness should be used for in women with postmenopausal bleeding in the ... Vaginal bleeding may occur at any age, but always needs investigation when encountered in children or in postmenopausal women. ... Premenopausal women[edit]. Most unusual bleeding or irregular bleeding (metrorrhagia) in premenopausal women is caused by ...
Ovaries that can be felt are also a sign of ovarian cancer in postmenopausal women. Other parts of a physical examination for ... Japanese women develop clear-cell ovarian cancer more frequently than other groups of women. Clear-cell adenocarcinomas are ... They occur most frequently in women between 50 and 69 years of age but can occur in women of any age, including young girls. ... In 2015 it was present in 1.2 million women and resulted in 161,100 deaths worldwide. Among women it is the seventh-most common ...
Predilection towards postmenopausal women. Metastasis of Paget cells from the epidermis to distant regions is a multistep ... In women, 81.3% of EMPD cases are related to the vulva, while for men, 43.2% of the manifestations present at the scrotum. The ... EMPD is most prevalent in Caucasian women and Asian men over the age of 60. The invasive form occurs in 5-25% of all EMPD ...
Postmenopausal women. 18 µg/day. 5-20 pg/mL. 30-70 pg/mL. 0.3-0.8 ... Female reproductive system[edit]. In the female, estradiol acts as a growth hormone for tissue of the reproductive organs, ... Adult female - free (not protein bound). 0.5[70][original research?]. 9[70][original research?]. pg/mL ... and postmenopausal women.[24] Skin hydration and surface lipids, on the other hand, did not significantly change with topical ...
Postmenopausal females. ,9.5 Interpretation[edit]. The ability to quantitate the βhCG level is useful in the monitoring germ ... In the case of female patients who want to be treated with HCG Pubergen, Pregnyl:[30] a) Since infertile female patients who ... In Pubergen, Pregnyl, Follutein, Profasi, Choragon and Novarel, it is extracted from the urine of pregnant women. In Ovidrel, ... Both male and female patients who have the following medical conditions must not start a treatment with HCG Pubergen, Pregnyl ...
In postmenopausal women, circulating levels of estradiol are below 15 pg/mL. During normal human pregnancy, estrogen production ... Barnes, Randall B.; Levrant, Seth G. (2007). "Pharmacology of Estrogens". Treatment of the Postmenopausal Woman. pp. 767-777. ... The metabolic fate and hepato-biliary-enteric circulation of C14-estrone and C14-estradiol in women". J. Clin. Invest. 36 (8): ... Mean integrated levels of circulating estradiol in premenopausal women across the whole menstrual cycle are in the range of 80 ...
1986). Estradiol levels after a single intramuscular injection of 10 mg estradiol enanthate in three postmenopausal women. ... Ginsburg, Elizabeth S. (1999). "Androgen Replacement in Postmenopausal Women". In Seifer, David B.; Kennard, Elizabeth A. (eds ... Studies in women and female capuchin monkeys have found that injections of estradiol enantate and DHPA significantly alter ... A case report of a prolactinoma in a transgender women treated with 10 mg estradiol enantate mixed with a progestin every 2 ...
... in postmenopausal women. Data on risk of breast cancer in women with newer progestins like drospirenone are lacking at present ... E2/DRSP has been found to increase bone mineral density and to reduce the occurrence of bone fractures in postmenopausal women ... Inhibition of ovulation occurred in about 90% of women at a dose of 0.5 to 2 mg/day and in 100% of women at a dose of 3 mg/day ... Archer DF (February 2007). "Drospirenone and estradiol: a new option for the postmenopausal woman". Climacteric. 10 Suppl 1: 3- ...
... and venous thromboembolism risk among postmenopausal women: the Women's Health Initiative Hormone Therapy clinical trials". ... The risk of breast cancer with estrogen and progestogen therapy in peri- and postmenopausal women is dependent on the duration ... Rogerio A. Lobo (5 June 2007). Treatment of the Postmenopausal Woman: Basic and Clinical Aspects. Elsevier. pp. 211-. ISBN 978- ... A 2015 Cochrane review provided strong evidence that the treatment of post-menopausal women with hormone therapy for ...
Nachtigall LE, Raju U, Banerjee S, Wan L, Levitz M (2000). "Serum estradiol-binding profiles in postmenopausal women undergoing ... 1022-. ISBN 978-0-7637-5329-0. Rogerio A. Lobo (5 June 2007). Treatment of the Postmenopausal Woman: Basic and Clinical Aspects ... Barnes, Randall B.; Levrant, Seth G. (2007). Treatment of the Postmenopausal Woman. pp. 767-777. doi:10.1016/B978-012369443-0/ ... The risk of thromboembolic and cardiovascular complications is significantly increased in postmenopausal women taking oral ...
While GTD overwhelmingly affects women of child-bearing age, it may rarely occur in postmenopausal women. GTD is the common ... In Western countries, women with molar pregnancies are followed carefully; for instance, in the UK, all women who have had a ... Women who undergo chemotherapy are advised not to conceive for one year after completion of treatment. These women also are ... Chittenden B, Ahamed E, Maheshwari A (August 2009). "Choriocarcinoma in a postmenopausal woman". Obstetrics and Gynecology. 114 ...
... postmenopausal, hypogonadal, and oophorectomized women, as well as for suppression of lactation in postpartum women. EDE was ... ISBN 978-1-4757-2085-3. Ginsburg, Elizabeth S. (1999). "Androgen Replacement in Postmenopausal Women". In Seifer, David B.; ... acting estrogen medication which was previously used in menopausal hormone therapy for women and to suppress lactation in women ... Al-Imari L, Wolfman WL (September 2012). "The safety of testosterone therapy in women". J Obstet Gynaecol Can. 34 (9): 859-865 ...
243-. ISBN 978-1-84214-311-7. Lobo, Rogerio A. (2001). "Androgens in Postmenopausal Women: Production, Possible Role, and ... and low sexual desire in women, and to treat breast cancer in women. It is taken by mouth or held in the cheek or under the ... Higher dosages of 50 to 200 mg/day have been used to treat women with inoperable breast cancer that has failed to respond to ... Circulating levels of methyltestosterone with administration of 1.25 to 2.5 mg/day oral methyltestosterone in women are in the ...
Bazedoxifene is used as treatment for osteoporosis in postmenopausal women at increased risk of fracture. It has been shown to ... Tamoxifen treatment is also useful in the treatment of bone density and blood lipids in postmenopausal women. Adverse effects ... In Europe, bazedoxifene is indicated for the treatment of osteoporosis in postmenopausal women at increased risk of fracture ... Gennari L, Merlotti D, Valleggi F, Nuti R (Jun 2009). "Ospemifene use in postmenopausal women". Expert Opinion on ...
Tosti, A; Piraccini, BM; Iorizzo, M; Misciali, C (2005). "Frontal fibrosing alopecia in postmenopausal women". Journal of the ...
Sengupta, Niladri; Hilliard, Timothy (2013). "Urogynecological Risk Assessment in Postmenopausal Women". www.medscape.com. ... The measurements are taken when the Valsalva maneuver is performed while The woman is in the dorsal lithotomy position. The ... Female Pelvic Medicine & Reconstructive Surgery. 18 (1): 33-34. doi:10.1097/spv.0b013e31823bd1ab. PMID 22453265. S2CID 26251358 ...
... for improving bone mass parameters evaluated by microdensitometry and/or single photon absorptiometry in postmenopausal women ... Iwamoto J (May 2014). "Vitamin K₂ therapy for postmenopausal osteoporosis". Nutrients. 6 (5): 1971-80. doi:10.3390/nu6051971. ... "Comparison of menaquinone-4 and menaquinone-7 bioavailability in healthy women". Nutrition Journal. 11 (93): 93. doi:10.1186/ ...
Friedlander, AH; Altman, L (2001). "Carotid artery atheromas in postmenopausal women. Their prevalence on panoramic radiographs ... postmenopausal women,[non-primary source needed] type 2 diabetics, individuals with dilated cardiomyopathy, and among ...
In postmenopausal women with osteoporosis, lasofoxifene at a dose of 0.5 mg per day was associated with reduced risks of ... "Lasofoxifene in postmenopausal women with osteoporosis". The New England Journal of Medicine. 362 (8): 686-96. doi:10.1056/ ... for the treatment of osteoporosis in postmenopausal women: focus on lasofoxifene". Clinical Interventions in Aging. 5: 19-29. ... It also appears to have had a statistically significant effect of reducing breast cancer in women according to a study ...
Women's Health "Perimenopausal and postmenopausal hormone replacement therapy. Part 1. An update of the literature on benefits ... Lichtman, along with several other women, founded a woman's magazine titled Up from Under. She both wrote and edited articles ... and under-served women. She eventually opened a private midwifery practice that focused on well-woman gynecologic care. ... She noted that this demeans neither the birthing woman nor the midwife and relates to both the midwife's role in helping women ...
... and postmenopausal women. Estrogen is responsible for the mediation of puberty in females, and in girls with delayed puberty ... Women who are not on a birth control pill or hormone therapy have a risk of VTE of about 1 to 5 out of 10,000 women per year. ... Rogerio A. Lobo (5 June 2007). Treatment of the Postmenopausal Woman: Basic and Clinical Aspects. Academic Press. pp. 177, 217- ... Scarabin PY (December 2014). "Hormones and venous thromboembolism among postmenopausal women". Climacteric. 17 Suppl 2: 34-7. ...
In the EU it is indicated for the treatment of moderate to severe symptomatic VVA in post-menopausal women who are not ... One of the phase 3 trials was a randomized, double-blind placebo-controlled trial in 826 post-menopausal women. The trial ... "FDA approves Osphena for postmenopausal women experiencing pain during sex". FDA News Release. U.S. Food and Drug ... Bachmann GA, Komi JO (2010). "Ospemifene effectively treats vulvovaginal atrophy in postmenopausal women: results from a ...
Wang PH, Cheng MH, Chao HT, Chao KC (June 2007). "Effects of tibolone on the breast of postmenopausal women". Taiwan J Obstet ... Wang PH, Cheng MH, Chao HT, Chao KC (June 2007). "Effects of tibolone on the breast of postmenopausal women". Taiwan J Obstet ... Biglia N, Maffei S, Lello S, Nappi RE (November 2010). "Tibolone in postmenopausal women: a review based on recent randomised ... Modelska K, Cummings S (January 2002). "Tibolone for postmenopausal women: systematic review of randomized trials". J. Clin. ...
... to 22.5 ng/mL for premenopausal women in the luteal phase and 0.12 to 1.0 ng/mL and 0.1 to 0.8 ng/mL in postmenopausal women, ... Normal progesterone levels in women Progesterone levels across the menstrual cycle in normally cycling, ovulatory women. The ... in postmenopausal women. Progesterone can be administered by subcutaneous injection, with Prolutex, an aqueous solution of ... in postmenopausal women. Progesterone levels following a single intramuscular injection of 25, 50, or 100 mg progesterone ...
Kloosterboer, H. J. (2009). "Tibolone is not aromatized in postmenopausal women". Climacteric. 11 (2): 175-176. doi:10.1080/ ... in the treatment of women with endometriosis. Additionally, noretynodrel has not been found to virilize female fetuses, in ... There is a reported case of signs of masculinization in a female infant whose mother was treated with noretynodrel for ... 1-. ISBN 978-3-88763-075-1. WILKINS L (March 1960). "Masculinization of female fetus due to use of orally given progestins". ...
Nappi, RE; Wawra, K; Schmitt, S (Jun 2006). "Hypoactive sexual desire disorder in postmenopausal women". Gynecological ... Level of desire is highly variable from female to female and there are some females who are considered sexually functional who ... HSDD affects approximately 10% of all pre-menopausal women in the United States, or about 6 million women. There are various ... and anorgasmia and vaginismus for women. Prior to Masters and Johnson's research, female orgasm was assumed by some to ...
S2CID 20060727 - via s10549-013-2597-8_. "BN83495 Phase I in Post-menopausal Women". NIH US National Library of Medicine ... in postmenopausal women with estrogen receptor-positive breast cancer". Breast Cancer Res. Treat. 140 (1): 73-82. doi:10.1007/ ... that have completed many clinical trials in women's health, including for hormone replacement therapy and endometriosis, post- ... Thomas, MP, Potter BVL (2015). "Discovery and Development of the Aryl O-Sulfamate Pharmacophore for Oncology and Women's Health ...
Women, specifically postmenopausal women, are at greatest risk of developing TTS. This has led some researchers to theorize ... It also affects far more women than men with 90% of cases being women, most postmenopausal. Scientists believe one reason is ... It occurs more commonly in postmenopausal women. The name "takotsubo" comes from the Japanese word takotsubo "octopus trap", ... For instance, estrogen, which confers protection to women by improving blood flow to heart muscle, is one biochemical pathway ...
About half of postmenopausal women are affected. Many however are not being treated. Women often report reduced enjoyment in ... Up to 50% of postmenopausal women have at least some degree of vaginal atrophy. It is likely to be underdiagnosed and ... Women may have many or a few symptoms so treatment is provided that best suits each woman. If other health problems are also ... Those women who are survivors of hormone-sensitive cancer may need to be treated more cautiously. Some women can have symptoms ...
"Risks and Benefits of Estrogen Plus Progestin in Healthy Postmenopausal Women: Principal Results From the Women's Health ... The Board of Trustees of The North American Menopause Society (2008). "Estrogen and progestogen use in postmenopausal women: ... Sood, R.; Shuster, L.; Smith, R.; Vincent, A.; Jatoi, A. (2011). "Counseling postmenopausal women about bioidentical hormones: ... 2009). "Breast cancer after use of estrogen plus progestin in postmenopausal women". NEJM. 360 (6): 573-87. doi:10.1056/ ...
... in postmenopausal women". Journal of the Society for Gynecologic Investigation. 7 (3): 175-83. doi:10.1016/s1071-5576(00)00049- ...
North American Menopause, Society (2010). "Estrogen and progestogen use in postmenopausal women: 2010 position statement of the ...
The STAR Trial: Evidence for Raloxifene as a Breast Cancer Risk Reduction Agent for Postmenopausal Women. J Natl Compr Canc ... 停經後(Postmenopausal)是指女性至少十二個月沒有月經的情形(前提是女性有子宮,且沒有懷孕也沒有哺乳)[39]。若是沒有子宮的女性,可以由血液檢查檢查是否有高濃度促卵泡激素(FSH)來判定。停經後是指女性最後一次月經出現之後的時期,也是卵巢變 ... EMAS clinical
... double-blinded Latin-square multiple cross-over study in postmenopausal osteopenic women". Eur. J. Clin. Invest. 33 (1): 41-50 ... "Loop diuretics increase bone turnover and decrease BMD in osteopenic postmenopausal women: results from a randomized controlled ...
Prevalence in post-menopausal women approaches that of men in the same age range. Women are at greater risk for developing OSA ... Consequently, females are less likely to be told by their partners that they snore, or to admit it to themselves or doctors. ... Women suffer typically less frequently and to a lesser degree than do men, owing partially to physiology, but possibly also to ... Furthermore, CPAP is also perceived negatively by females, and less likely to be utilized to its full extent in this group.[4] ...
In post-menopausal women, sexual activity does not affect the risk of developing a UTI.[4] Spermicide use, independent of ... Women are more prone to UTIs than men because, in females, the urethra is much shorter and closer to the anus.[30] As a woman's ... In cases where infections are related to intercourse, taking antibiotics afterwards may be useful.[6] In post-menopausal women ... In women, they are the most common form of bacterial infection.[17] Up to 10% of women have a urinary tract infection in a ...
Osteoporosis is most common in women after menopause, when it is called postmenopausal osteoporosis, but may also develop in ... "The association between obesity and the frailty syndrome in older women: the Women's Health and Aging Studies". J Am Geriatr ... "Impact of anemia and cardiovascular disease on frailty status of community-dwelling older women: the Women's Health and Aging ... Osteoporosis is defined by the World Health Organization (WHO) in women as a bone mineral density 2.5 standard deviations below ...
47.0 47.1 Kanai, T (1997). "Serum vitamin K level and bone mineral density in post-menopausal women". International Journal of ... is associated with reduced bone loss in postmenopausal women: Japanese Population-Based Osteoporosis (JPOS) Study.". The ... is associated with bone mineral density in premenopausal women.". Journal of nutritional science and vitaminology 48 (3): 207- ... "Vitamin K intake and hip fractures in women: a prospective study". American Journal of Clinical Nutrition 69 (1): 74. பப்மெட் ...
It is not indicated for women and is not recommended in pregnant women. Treatment is effective starting within 6 weeks of ... postmenopausal frontal fibrosing alopecia, etc.). Tumours and skin outgrowths also induce localized baldness (sebaceous nevus, ... Female-pattern hair loss occurs at the frontal and parietal. People have between 100,000 and 150,000 hairs on their head. The ... Hair typically grows back normally and treatment is not indicated.[21][22] A similar situation occurs in women taking the ...
Sandra Z. Haslam; Janet R. Osuch (1 January 2006). Hormones and Breast Cancer in Post-Menopausal Women. IOS Press. pp. 42, 69. ... female GHR knockout mice can lactate normally.[17][19] As such, it has been said that the phenotypes of women with Laron ... and the male and female breast do not show any differences.[20] During puberty in females, estrogen, in conjunction with GH/IGF ... International position paper on women's health and menopause : a comprehensive approach. DIANE Publishing. 2002. pp. 78-. ISBN ...
... married women and women of childbearing age suffer more psychological distress after rape than single or postmenopausal women, ... Sexual coercion functions to increase the chance of a female mating with a male, and decrease the chance that the female will ... and so a chaste male is not highly valued by women.[citation needed] However, for men, female chastity confirms paternity, ... This can result in men being more likely than women to view pressuring a woman or girl into sex as acceptable behavior.[17] A ...
In postmenopausal cases lean women have significantly better prognosis than obese women. Among patients with distant metastasis ... The overall rate is 1.3 cases per 100000, black women (1.6) have the highest rate, Asian and Pacific Islander women the lowest ... Inflammatory breast cancer[1] is one of the most aggressive types of breast cancer that can occur in women of any age (and, ... IBC makes up only a small percentage of breast cancer cases (1-6% in the USA[4]). IBC is often diagnosed in younger women ...
... ratio of dietary animal to vegetable protein increases the rate of bone loss and the risk of fracture in postmenopausal women. ...
Milne DB, Nielsen FH (March 1996). "Effects of a diet low in copper on copper-status indicators in postmenopausal women". The ...
... rates are much higher in post-menopausal older women due to estrogen deficiency related with menopause. Common ...
"Comparison of dietary conjugated linoleic acid with safflower oil on body composition in obese postmenopausal women with type 2 ... showing that body fat decreased and adiponectin levels increased in obese women consuming safflower oil.[5] ...
In postmenopausal women not receiving HRT, the recommended dose is 10 mg daily or 70 mg weekly. Paget's disease: 40 mg daily ... Treatment of post-menopausal women and people with osteogenesis imperfecta over the age of 22 with alendronic acid has ... Lenart BA, Lorich DG, Lane JM (March 2008). "Atypical fractures of the femoral diaphysis in postmenopausal women taking ... Prophylaxis of osteoporosis in women: 5-10 mg daily or 35-70 mg weekly. Therapy of osteoporosis in women and men : 10 mg daily ...
Im JA, Yu BP, Jeon JY, Kim SH (2008). „Relationship between osteocalcin and glucose metabolism in postmenopausal women.". Clin ... 2009). „Changes of bone formation markers osteocalcin and bone-specific alkaline phosphatase in postmenopausal women with ... 2008). „SNP combinations in chromosome-wide genes are associated with bone mineral density in Taiwanese women.". Chin J Physiol ...
Kerr D, Morton A, Dick I, Prince R (1996). "Exercise effects on bone mass in postmenopausal women are site-specific and load- ... 2004). "The effects of strontium ranelate on the risk of vertebral fracture in women with postmenopausal osteoporosis". N. Engl ... 2002). "Exercise for preventing and treating osteoporosis in postmenopausal women". Cochrane database of systematic reviews ( ... 2005). "Strontium ranelate reduces the risk of nonvertebral fractures in postmenopausal women with osteoporosis: treatment of ...
"Randomized trial of estrogen plus progestin for secondary prevention of coronary heart disease in postmenopausal women. Heart ... help) (the Women's Health, Osteoporosis, Progestin, Estrogen study). *Hulley S, Grady D, Bush T et al. (August 1998). " ...
"Risks and Benefits of Estrogen Plus Progestin in Healthy Postmenopausal Women: Principal Results From the Women's Health ... "Effects of Conjugated Equine Estrogen in Postmenopausal Women with Hysterectomy: The Women's Health Initiative Randomized ... For most women, the majority of change occurs during the late perimenopausal and postmenopausal stages.[4] Decrease in sex ... In postmenopausal women, continuous combined estrogen plus progestin decreases endometrial cancer incidence.[29] The duration ...
"Prospective study of grapefruit intake and risk of breast cancer in postmenopausal women: the Multiethnic Cohort Study". Br. J ...
Long term hormone therapy for perimenopausal and postmenopausal women. The Cochrane Database of Systematic Reviews. 2012;7: ... Irvine K. Greater cognitive deterioration in women than men with Alzheimer's disease: a meta analysis. Journal of Clinical and ... Spatial Learning, Exploration, Anxiety, and Motor Coordination in Female APP23 Transgenic Mice with the Swedish Mutation. Brain ...
Likewise, postmenopausal women taking anticonvulsants have a greater risk of fracture than their drug-naive counterparts.[27] ... postmenopausal women, older men, people taking more than one anticonvulsant, and children, who are also at risk of rickets.[27] ... Bruno, M. K.; C. L. Harden (January 2002). "Epilepsy in Pregnant Women". Current Treatment Options in Neurology. 4 (1): 31-40. ... However, only one quarter of the women were affected vs. half of the men.[22] Thirty-five years later, Critcheley et al. ...
Notes: (1) Only in women who are at least 5 years postmenopausal. (2) Dosages are not necessarily equivalent. Sources: See ... In 1960, DES was found to be more effective than androgens in the treatment of advanced breast cancer in postmenopausal women.[ ... "Delalutin and estrogens for the treatment of advanced mammary carcinoma in the postmenopausal woman". Cancer. 18: 436-46. doi: ... 103] DES was the hormonal treatment of choice for advanced breast cancer in postmenopausal women until 1977, when the FDA ...
"Moderate alcohol consumption lowers risk factors for cardiovascular disease in postmenopausal women fed a controlled diet". Am ... "Identification and fracture outcomes of undiagnosed low bone mineral density in postmenopausal women: results from the National ... "Alcohol intake is associated with a lower prevalence of peripheral vascular disease in non-insulin dependent diabetic women". ... "fMRI measurement of brain dysfunction in alcohol-dependent young women". Alcohol. Clin. Exp. Res. 25 (2): 236-45. doi:10.1111/ ...
"Choline and betaine intake and risk of breast cancer among post-menopausal women". British Journal of Cancer 102 (3): 489-94. ... Choline status in newborns, infants, children, breast-feeding women, breast-fed infants, and human breast milk. Journal of ... "Nutrients involved in one-carbon metabolism and risk of breast cancer among premenopausal women". Cancer Epidemiology, ... "Dietary intake of choline and plasma choline concentrations in pregnant women in Jamaica". The West Indian Medical Journal 54 ...
1999). "Calcitonin receptor polymorphism is associated with a decreased fracture risk in post-menopausal women". Hum. Mol. ... 2000). "Calcitonin receptor mRNA in mononuclear leucocytes from postmenopausal women: decrease during osteoporosis and link to ... distribution and association with bone mass in postmenopausal Italian women". Biochem. Biophys. Res. Commun. 245 (2): 622-6. ...
... and ethinylestradiol levels over 24 hours after a single oral dose of 10 mg NETA in postmenopausal women.[29] ... but also with improvement of menopausal symptoms in postmenopausal women.[35] It has been suggested that very high dosages (e.g ... were noted in any of the women.[31][32] Another study of 5 mg/day norethisterone in 132 women also made no mention of ... "In vivo conversion of norethisterone and norethisterone acetate to ethinyl etradiol in postmenopausal women". Contraception. 56 ...
In post-menopausal women, however, any genital bleeding is an alarming symptom that requires an appropriate study to rule out ... initially being closely related to the males and females. Females are born and stay in the group, so relatedness to the females ... It is also argued that since the population fraction of post-menopausal women in early Homo sapiens was so low, menopause had ... The term "postmenopausal" describes women who have not experienced any menstrual flow for a minimum of 12 months, assuming that ...
Scientists are recommending that women are given the male sex hormone testosterone to help reduce fat and build up muscle once ... Testosterone aids post-menopausal women Middle-aged women tend to lose muscle and put on fat The male sex hormone ... In the four-month study of 40 post-menopausal women aged 48 and 65 conducted at Johns Hopkins, fat tissue in the women ... As women go through the menopause there is a natural increase in fat. Women live for an average of 30 years after the menopause ...
Post-menopausal females who take statins have been found to have a higher risk of developing diabetes, researchers from various ... "Statin medication use in postmenopausal women is associated with an increased risk for diabetes mellitus.". The Womens Health ... even for females in the mentioned age-groups.. Their six-to-seven year study, involving thousands of women from the Womens ... Post-menopausal females who take statins have been found to have a higher risk of developing diabetes, researchers from various ...
Women who are going through menopause often experience a variety of physical side effects, but these issues may be exacerbated ... Researchers followed a cross-sectional sample of 3,503 postmenopausal Latin American women. Women who experienced anxiety were ... Study Explores Anxiety Among Postmenopausal Women February 7, 2017 • Contributed by Zawn Villines, GoodTherapy.org ... www.news-medical.net/news/20170125/Anxiety-linked-to-severe-quality-of-life-impairment-in-postmenopausal-women.aspx ...
Data are insufficient for assessment of the risk of long-term HT use in perimenopausal women and in postmenopausal women ... None of the studies focused on perimenopausal women.In relatively healthy postmenopausal women (i.e. generally fit, without ... Long-term hormone therapy for perimenopausal and postmenopausal women.. Marjoribanks J1, Farquhar C1, Roberts H1, Lethaby A1, ... Long term hormone therapy for perimenopausal and postmenopausal women. [Cochrane Database Syst Rev. 2012] ...
Risedronate reduces bone marrow fat in postmenopausal women. These findings are the first demonstration of an effect of ... In this study, we demonstrate that risedronate prevents marrow fat infiltration in postmenopausal women after 3 years of ... Effects of estrogen therapy on bone marrow adipocytes in postmenopausal osteoporotic women. Osteoporos Int 19:1323-1330PubMed ... Effects of long-term risedronate on bone quality and bone turnover in women with postmenopausal osteoporosis. Bone 31:620-625 ...
Physical activity and mortality in postmenopausal women.. Kushi LH1, Fee RM, Folsom AR, Mink PJ, Anderson KE, Sellers TA. ... Subjects were 40417 postmenopausal Iowa women, aged 55 to 69 years at baseline in 1986. Physical activity was assessed by ... To evaluate the association between physical activity and all case mortality in postmenopausal women. ... inverse association between physical activity and all-cause mortality in postmenopausal women. These findings strengthen the ...
An overview of the approach to therapy of osteoporosis in postmenopausal women will be presented here. The diagnosis and ... Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results From the Womens Health ... Overview of the management of osteoporosis in postmenopausal women. Authors. Harold N Rosen, MD. Harold N Rosen, MD ... Identification of early postmenopausal women with no bone response to HRT: results of a five-year clinical trial. Osteoporos ...
Researchers in the latest issue of Harvard Women s Health Watch had explored the physiology of hot flashes experienced by some ... Womens Health Watch had explored the physiology of hot flashes experienced by some women in their menopausal or postmenopausal ... explains the Harvard Womens Health Watch. The authors also discussed why the thermoneutral zone is narrower in women with hot ... Women who have hot flashes have a thermoneutral zone thats so narrow, even the tiniest changes in core body temperature can ...
New research suggests that post-menopausal women who walk at an average pace for 40 minutes several times per week decrease ... Post-menopausal woman walking at an average pace for at least 40 minutes several times per week can reduce their risk of heart ... March 1 (UPI) -- If post-menopausal women walk at an average pace for at least 40 minutes several times per week, their risk of ... Study: Walking may protect post menopausal women from heart failure. "We already know that physical activity lowers the risk of ...
... Osteoporos Int. 2001;12(7):519-28. doi: 10.1007/ ... The FRACTURE Index can be used either with or without BMD testing by older postmenopausal women or their clinicians to assess ... Using data from the Study of Osteoporotic Fractures (SOF), a total of 7782 women age 65 years and older with bone mineral ... and could be useful in helping to determine the need for further evaluation and treatment of these women. ...
Calcium Supplementation in Postmenopausal Women (CAP). The safety and scientific validity of this study is the responsibility ... Women who are postmenopausal with at least one year since their last menstruation. If a subjects menopausal status at ... in postmenopausal women with osteoporosis. The primary objective of this clinical study is to evaluate whether increases in ... have been documented in a dose-finding Phase II clinical trial in osteoporotic postmenopausal women, supplemented with calcium ...
Fifty-five postmenopausal women with depression symptoms, who were not in use of hormones or antidepressants, were included in ... Here we investigated the association of ghrelin with depression and anxiety symptoms in postmenopausal women. ... first demonstration of an association between acylated ghrelin and the severity of depression symptoms in postmenopausal women ... Women were allocated into three groups, according to BDI classification of mild, moderate, or severe depression symptoms. ...
Clinicians should consider screening for sexually transmitted infections in older women at high risk. Postmenopausal women ... Major guidelines concur that women at average risk of breast cancer benefit from screening mammography at least every other ... Several effective options for colorectal cancer screening are recommended for women 50 to 75 years of age. Cervical cancer ... use the pooled cohort risk assessment equations or another risk calculator every three to five years to estimate a womans 10- ...
In postmenopausal women with osteoporosis, lasofoxifene at a dose of 0.5 mg per day was associated with reduced risks of ... Lasofoxifene in postmenopausal women with osteoporosis N Engl J Med. 2010 Feb 25;362(8):686-96. doi: 10.1056/NEJMoa0808692. ... Endometrial cancer occurred in three women in the placebo group, two women in the lower-dose lasofoxifene group, and two women ... Conclusions: In postmenopausal women with osteoporosis, lasofoxifene at a dose of 0.5 mg per day was associated with reduced ...
... postmenopausal HIV-infected women have a high prevalence of low bone mineral density and high bone turnover placing them at ... "Although numbers of HIV-infected postmenopausal women are increasing and postmenopausal women are at highest risk for ... postmenopausal women had lower bone mineral density at both the spine and hip than HIV-negative postmenopausal women. ... HIV-infected postmenopausal women at high risk for bone fractures With potent therapies comes longer life for HIV-infected ...
This study examined bone density among postmenopausal Buddhist nuns and female religious followers of Buddhism in southern ... A total of 258 postmenopausal Taiwanese vegetarian women participated in the study. Lumbar spine and femoral neck bone mineral ... This study examined bone density among postmenopausal Buddhist nuns and female religious followers of Buddhism in southern ... Long-Term Vegetarian Diet and Bone Mineral Density in Postmenopausal Taiwanese Women. ...
A Study of MF101 in Postmenopausal Women (HERBA). The safety and scientific validity of this study is the responsibility of the ... A Study of MF101 in Postmenopausal Women. Official Title ICMJE A Phase 3, Double-blind, Placebo-Controlled, Randomized Clinical ... Approximately 1200 healthy post-menopausal women, aged 40-65, with moderate to severe hot flushes will be enrolled to determine ... Assessing Safety and Efficacy of MF101 for Hot Flushes and Menopausal Symptoms in Postmenopausal Women. ...
PTH Comparison in Post Menopausal Women. The safety and scientific validity of this study is the responsibility of the study ... Ambulatory, postmenopausal women aged 55-85 years (at least 3 years have elapsed after menopausal) are included at the time of ... To compare in postmenopausal women with established osteoporosis the effect of treatment with teriparatide 20 micrograms/day ... To compare in postmenopausal women with established osteoporosis the effect of treatment with teriparatide 20 micrograms/day ...
... especially in postmenopausal women [11]. Men, on the other hand, have a greater total bone mass than women, hence they are less ... H. Lily, N. H. Nik Hazlina, S. Siti Amrah et al., "The effects of Tualang honey on postmenopausal women," in Proceedings of the ... Postmenopausal women are more prone to osteoporosis due to reduction in estrogen which may further lead to elevation of ... Hence, any factors that can impair the rate of bone remodelling will contribute to bone loss such as in postmenopausal women ...
Low bone mineral density and fracture burden in postmenopausal women. Ann Cranney, Sophie A. Jamal, James F. Tsang, Robert G. ... Low bone mineral density and fracture burden in postmenopausal women. Ann Cranney, Sophie A. Jamal, James F. Tsang, Robert G. ... in women with osteopenia and 40% (26.2 per 1000 person-years) in women with osteoporosis. Fracture incidence rates in women ... Low bone mineral density and fracture burden in postmenopausal women. Ann Cranney, Sophie A. Jamal, James F. Tsang, Robert G. ...
Post-menopausal therapy to improve womens quality of life. 30.05.2008. A recent research work by the University of Granada ... advises post-menopausal women the use of Replacement Hormone Therapy (RHT) for at least five years. ... A study carried out at the University of Granada on more than 500 postmenopausal patients rationalizes the fears above ... there are medical treatments which contribute to maintain the quality of life of women in the face of the described changes. ...
We studied 77 postmenopausal women with no history of osteoactive drug therapy, corticosteroid intake or diseases that could ... This study shows high hypovitaminosis D occurrence among these postmenopausal women. ... D concentration among patients who had reported fractures was significantly lower than the corresponding to women who had not ... and higher uncompromised vertebrae wedge angle values than non-deficient women. ...
Women with the highest bone mass are at much greater risk of postmenopausal breast cancer than those with lower bone mass, ... These women were then monitored over a 26-year period, during which time 91 women developed postmenopausal breast cancer. After ... Women with the highest bone mass are at a much greater risk of postmenopausal breast cancer than those with lower bone mass, ... While about 44,000 women died of breast cancer in 1994, approximately 370,000 died of heart disease. The Postmenopausal ...
... have been using a vaginal form of estrogen therapy do not have a higher risk of cardiovascular disease and cancer than women ... "For post-menopausal women, vaginal estrogens do not raise risk of cancer, other diseases." Medical News Today. MediLexicon, ... 2017, August 18). "For post-menopausal women, vaginal estrogens do not raise risk of cancer, other diseases." Medical News ... For post-menopausal women, vaginal estrogens do not raise risk of cancer, other diseases. ...
Taking the calcium and vitamin D supplements was especially helpful in raising vitamin D levels in women who were older, women ... Daily, the women in the WHI CaD trial took either a supplement containing 1,000 mg of calcium and 400 IU of vitamin D3 or a ... The women who took the supplement were more than twice as likely to have vitamin D levels of at least 30 ng/mL (normal ... And studies of women taking the combination could not separate the effects of calcium from those of vitamin D on cholesterol. ...
A single blood test can help define a womans risk. • Elevated hormone levels associated with breast cancer death and ... Among eligible postmenopausal women not using postmenopausal hormones (PMH) at blood collection, 796 cases were diagnosed ... Women in the highest 25 percent of SHBG levels had a 30 percent lower risk for breast cancer compared with women in the lowest ... Blood hormone tests predicted a womans risk for developing postmenopausal breast cancer for up to 20 years, according to data ...
In postmenopausal women, the serum ferritin was higher, 71 μg/L, than in premenopausal women, 37 μg/L. The postmenopausal ... in postmenopausal women a higher serum ferritin was not correlated with a lower bone mass [8, 9]. In postmenopausal women with ... In women aged 50-79 the geometric mean for the serum ferritin was 87 μg/L [15]. In postmenopausal women aged 54-64 there was a ... All postmenopausal women in our institution who had had an HFE gene analysis between 1999 and 2012 were identified. Women ...
Control subjects (n = 122) were treated diabetic women drawn from a stratified random sample of postmenopausal women without ... Postmenopausal Estrogens and Risk of Myocardial Infarction in Diabetic Women. Robert C Kaplan, Susan R Heckbert, Noel S Weiss, ... Postmenopausal Estrogens and Risk of Myocardial Infarction in Diabetic Women. Robert C Kaplan, Susan R Heckbert, Noel S Weiss, ... Postmenopausal Estrogens and Risk of Myocardial Infarction in Diabetic Women Message Subject (Your Name) has forwarded a page ...
Among the women with benign lesions, postmenopausal women had significantly higher polyunsaturated fatty acids and lower ... "While increased BMI may provide a protective effect for premenopausal women, postmenopausal women have an increased risk of ... acids were present in the breast tissue of postmenopausal women with invasive ductal carcinoma than in postmenopausal women ... Saturated Fats Increase Risk of Breast Cancer in Postmenopausal Women. by Shirley Johanna on June 7, 2016 at 2:58 PM Cancer ...
Our results confirm that postmenopausal obese women who undergo anterior or posterior colporrhaphy need a follow-up concerning ... Pelvic floor muscle function of 30 overweight postmenopausal women prior to and after colporrhahpy was monitored in this study ... Hock, M. , Domány, B. , Bódis, J. and Garai, J. (2014) Does Surgery Benefit Postmenopausal Overweight Women with Pelvic Floor ... Introduction: Pelvic floor muscle function of 30 overweight postmenopausal women prior to and after colporrhahpy was monitored ...
  • Previous research has found that oestrogen-androgen therapy may also help improve bone density in post-menopausal women. (bbc.co.uk)
  • While we all know that exercise is good for us and good for your heart health, I had to wonder if there were any differences in the amount of exercise that is required for post-menopausal women. (empowher.com)
  • Post-menopausal females who take statins have been found to have a higher risk of developing diabetes , researchers from various medical schools in Massachusetts and other US faculties reported in Archives of Internal Medicine . (medicalnewstoday.com)
  • Post-menopausal woman walking at an average pace for at least 40 minutes several times per week can reduce their risk of heart disease by nearly 25 percent, according to a new study. (upi.com)
  • March 1 (UPI) -- If post-menopausal women walk at an average pace for at least 40 minutes several times per week, their risk of heart disease will drop nearly 25 percent, according to new findings. (upi.com)
  • 1 This article reviews evidence-based preventive services recommendations for asymptomatic post-menopausal women from the U.S. Preventive Services Task Force (USPSTF), which are supported by the American Academy of Family Physicians. (aafp.org)
  • Approximately 1200 healthy post-menopausal women, aged 40-65, with moderate to severe hot flushes will be enrolled to determine the safety and efficacy of two doses of MF101 (5 g/day and 10 g/day) compared to placebo after 12 weeks of treatment. (clinicaltrials.gov)
  • A recent research work by the University of Granada advises post-menopausal women the use of Replacement Hormone Therapy (RHT) for at least five years. (innovations-report.com)
  • Our objectives were to study for the first time the effects of the female menopause on hair lipids, the contribution of sebum, and hair quality using pre-menopausal and post-menopausal subjects with and without hormone replacement therapy. (ingentaconnect.com)
  • It has also been used for the prevention of cardiovascular disease in post-menopausal women. (healthypeople.gov)
  • Rather, hormone therapy in post-menopausal women increased the risk of stroke and obstruction of a vein by a blood clot. (healthypeople.gov)
  • Boardman HMP, Hartley L, Eisinga A, Main C, Roqué i Figuls M, Bonfill Cosp X, Gabriel Sanchez R, Knight B. Hormone therapy for preventing cardiovascular disease in post-menopausal women. (healthypeople.gov)
  • These studies involved over 56,000 cases of breast cancer across four continents and found that post-menopausal women with type II diabetes had a 27 per cent increased risk of breast cancer. (cancerresearchuk.org)
  • The increase in breast cancer risk seems to be restricted to post menopausal women with type II diabetes, as the research found no link between women of pre-menopausal age or those with type I diabetes. (cancerresearchuk.org)
  • Professor Peter Boyle, President of i-PRI and lead author of the study, said: "Our study found a significantly increased risk of breast cancer in women who had diabetes, which was restricted to those of post-menopausal age. (cancerresearchuk.org)
  • Martin Ledwick, head information nurse at Cancer Research UK, said: "From this study, it's not clear whether there's a causal link between diabetes and the risk of breast cancer in post menopausal women. (cancerresearchuk.org)
  • The findings come from the Women's Health Initiative's hormone therapy trials, which were launched to assess the benefits and risks to mostly healthy post-menopausal women of taking hormone-replacement pills in a bid to reduce their risk of developing such cardiovascular and other chronic diseases. (latimes.com)
  • In this large, national cohort of post-menopausal women, residential proximity to major roadways was associated with incident hypertension in selected regions of the U.S. If causal, these results suggest residential proximity to major roadways, as a marker for air, noise and other traffic-related pollution, may be a risk factor for hypertension. (healthpartners.com)
  • A group of 417 post-menopausal women aged 60 to 80 were randomly assigned to receive a daily .014 milligram dose of either estradiol, a form of estrogen, or a placebo through a skin patch for two years. (rxpgnews.com)
  • The purpose of this study is to determine whether the phytoestrogen genistein is effective in improving bone condition in pre-menopausal and post-menopausal women suffering for osteopenia. (bioportfolio.com)
  • Post-menopausal women who suffer from gum disease and tooth loss may be at a higher risk of death, according to a study. (hindustantimes.com)
  • Weight is the biggest factor affecting the level of sex hormones that increase breast cancer risk in post menopausal women, according to new research published in the British Journal of Cancer today (Wednesday). (cancerresearchuk.org)
  • The Cancer Research UK funded study examined how levels of sex hormones* - known to affect breast cancer risk - varied among post menopausal women. (cancerresearchuk.org)
  • The analysis combined the records of nearly 6,300 post menopausal women from 13 different studies. (cancerresearchuk.org)
  • The biggest increases were for oestrogens, and this increase in oestrogen may explain why post menopausal, obese women are at higher risk for breast cancer. (cancerresearchuk.org)
  • Peri- and post-menopausal women frequently complain of insomnia or poor sleep quality. (womensmentalhealth.org)
  • We previously reported on studies suggesting estrogen may be helpful for the treatment of depression in peri- and post-menopausal women, either alone or in combination with an antidepressant. (womensmentalhealth.org)
  • The objective of this study was to evaluate and compare the preference of chocolate milk products sweetened with sucrose and stevia by pre- and post-menopausal women and to examine their concerns about bone health. (scirp.org)
  • Women panelists were divided into two groups according to age: pre- menopausal (from 18 to 47 years old) and post-menopausal (over 48 years old) and answered the frequency of white and chocolate milk consumption during a week and their concerns about bone health. (scirp.org)
  • The results showed that both groups (pre- and post- menopausal women) prefer chocolate milk to white milk. (scirp.org)
  • and chocolate milk with sucrose vs. chocolate milk with sucrose and stevia, there were no visible differences between pre- and post-menopausal women. (scirp.org)
  • Pre-menopausal women showed a greater positive impact on milk choice when being informed the amount of fibers in the sample than post-menopausal women. (scirp.org)
  • Researchers at Florida State University have found that post-menopausal women can benefit from eating two apples a day. (ausfoodnews.com.au)
  • The data demonstrate a rapid uptake of hPTH(1-34), a pharmacokinetic profile that is consistent with our earlier studies in younger subjects, and pharmacodynamics in post-menopausal women consistent with the known activity of hPTH(1-34) in promoting bone growth. (cnbc.com)
  • We undertook this study to compare reported and measured loss of height among post-menopausal women in a primary care setting. (cmaj.ca)
  • In a study of over 100,000 women, researchers found that post-menopausal women had higher cholesterol levels than premenopausal women. (medicalxpress.com)
  • Mr Ananthan Ambikairajah, a Ph.D. Scholar from ANU, said the study found on average, post-menopausal women had above recommended levels of low density lipoproteins (LDL). (medicalxpress.com)
  • We found post-menopausal women had higher cholesterol levels compared to premenopausal women ," Mr Ambikairajah said. (medicalxpress.com)
  • It could be really useful for post- menopausal women that have moderate risks-like obesity or low physical activity-to connect with their GP and get their LDL levels checked. (medicalxpress.com)
  • Post menopausal women who take hormones for more than five years to relieve symptoms such as hot flashes have twice the risk of developing breast cancer as women who do not take estrogen and progestin to replace their own dwindling supplies, according to a new analysis of over 16,000 post-menopausal woman. (scientificamerican.com)
  • Post-menopausal women who engage in moderate to vigorous exercise have. (bio-medicine.org)
  • Over 110000 post menopausal women were asked to rate their level of p. (bio-medicine.org)
  • Over 110,000 post menopausal women were asked to rate their level of physical activity at ages 15-18, 19-29, 35-39, and in the past 10 years. (bio-medicine.org)
  • Hypertension is probably the most important cardiovascular risk factor in post-menopausal women,' Dr. Harvey said. (womenshealthmatters.ca)
  • Given the many protective effects of estrogen, it's not surprising that researchers suspect that estrogen deficiency following menopause is one of the contributing factors to the increase in hypertension that often occurs in post-menopausal women. (womenshealthmatters.ca)
  • Elevated percentages of R5+CD4+ T lymphocytes in cervix may increase the risk for HIV acquisition in post-menopausal vs pre-menopausal women. (natap.org)
  • We hypothesized that these measures would be higher in cervical CD4+ T cells of healthy post-menopausal compared to pre-menopausal women. (natap.org)
  • Methods: Whole blood was collected from healthy pre-menopausal (early follicular phase, day 1 to 5 of menstrual cycle) and post-menopausal women. (natap.org)
  • Results: Median ages of post-menopausal (n = 24) and pre-menopausal women (n = 21) were 55 (range 50 to 65) and 34 (range 23 to 49) years, respectively. (natap.org)
  • The blood plasma and genital tract AUC and trough concentrations of TDF, are significantly increased in post-menopausal women receiving chronic TDF. (natap.org)
  • Understanding how these changes impact systemic and genital tract ARV exposure in post-menopausal women compared to pre-menopausal women is critical as the HIV+ population ages. (natap.org)
  • and 5 African American and 1 Hispanic post-menopausal women. (natap.org)
  • At steady state, post-menopausal women had greater exposure in both blood plasma (p = 0.02) and genital tract (p = 0.01), resulting in similar genital tract : blood plasma ratios. (natap.org)
  • There is a lot of data suggesting that reduced levels of estrogen hormones in post-menopausal women affects periodontal tissues and may contribute to the onset of periodontitis in post-menopausal women, separate from the impact of insufficient estrogen hormones on alveolar bone. (34-menopause-symptoms.com)
  • Outlined below is the theory that, in post-menopausal women, estrogen hormones deficiency is a risk for periodontal disease and that resulting tooth loss and use of hormone/estrogen hormones replacement therapy can prevent gum deterioration. (34-menopause-symptoms.com)
  • Loss of alveolar bone in post-menopausal women leads to, among other things, retracting gum margins, and development of periodontitis. (34-menopause-symptoms.com)
  • The effect of reduced levels of estrogen hormones precisely on alveolar bone in post-menopausal women does not fully detail the relationship between a lack of estrogen hormones and tooth loss. (34-menopause-symptoms.com)
  • A lot of reports have suggested a positive influence of estrogen hormones directly on periodontal tissues, despite the fact that this idea is not highlighted in current reviews of risk factors for periodontal disease in post-menopausal females. (34-menopause-symptoms.com)
  • Around 30 years ago, tooth loss was more widespread among post-menopausal women suffering from osteoporosis aged 60 to 69 years. (34-menopause-symptoms.com)
  • Dr Daniell found that no post-menopausal woman had faced tooth loss during the years in which she was receiving hormone/estrogen hormones replacement therapy (H/ERT), even if she had developed osteoporosis. (34-menopause-symptoms.com)
  • This suggested relatively healthy dental soft tissues in post-menopausal women during hormone/estrogen hormones replacement therapy even with reduced alveolar bone. (34-menopause-symptoms.com)
  • Other analyses have noted diminished tooth loss in post-menopausal women using estrogen hormones, diminished gingival bleeding during estrogen hormones use even after controlling for other factors contributing to periodontitis in estrogen hormones-deficient post-menopausal women. (34-menopause-symptoms.com)
  • Such data indicates a capability for hormone/estrogen hormones replacement therapy in the prevention and care of post-menopausal women with periodontitis. (34-menopause-symptoms.com)
  • A common pattern continues to be nonsmoking post-menopausal women free of diabetes mellitus in their 50s and 60s with periodontal disease that significantly improves within a number of months of starting systemic estrogen hormones treatment. (34-menopause-symptoms.com)
  • The data above describes for post-menopausal women the role of estrogen hormones shortage as a risk for periodontal disease and tooth loss as well as how hormone/estrogen hormones replacement therapy could stop gum deterioration. (34-menopause-symptoms.com)
  • For post-menopausal women findings from observational or small group studies link estrogen hormones deficiency to risk of soft tissue disease. (34-menopause-symptoms.com)
  • Yet, the degree to which H/ERT is successful in preventing soft tissue deterioration in post-menopausal women can only be established with a placebo-controlled, randomized trial which would be somewhat unethical given that it would require leaving participants suffering from periodontal disease untreated. (34-menopause-symptoms.com)
  • Tibolone is a type of hormone therapy (HT) designed to relieve menopausal symptoms and prevent osteoporosis (thinning of the bones) in post-menopausal women. (menopause.org.au)
  • Contrary to what doctors have been recommending for years, the U.S. Preventive Services Task Force announced this week that healthy postmenopausal women should not take daily low doses of vitamin D and calcium to prevent bone fractures because there is insufficient research to show benefit, and the supplements may even be linked to a slightly increase risk for kidney stones and heart attacks . (mnn.com)
  • Circulating interleukin-8 and tumor necrosis factor-α are associated with hot flashes in healthy postmenopausal women. (bioportfolio.com)
  • Circulating leptin and adiponectin are associated with insulin resistance in healthy postmenopausal women with hot flashes. (bioportfolio.com)
  • They included more than 1,61,000 generally healthy postmenopausal women, aged 50 to 79. (topnews.in)
  • Aerobic exercise training in healthy postmenopausal women: effects of hormone therapy. (biomedsearch.com)
  • OBJECTIVE: We investigated the influence of hormone therapy (HT) on submaximal central and peripheral function in healthy postmenopausal women after 12 weeks of endurance training. (biomedsearch.com)
  • CONCLUSIONS: These findings suggest that in healthy postmenopausal women, 12 weeks of aerobic training is effective in eliciting favorable cardiovascular adaptations, regardless of the presence of short-term HT. (biomedsearch.com)
  • One hundred fifty-seven healthy postmenopausal women (age 65 ± 6) were randomized to a 500 mg isoflavonoid-rich herbal preparation containing tannins from grape seeds, green tea leaves, hop cone powder, and garlic powder, or placebo. (mdpi.com)
  • A total of 35 healthy postmenopausal women were recruited (59 ± 3 years) and cardiorespiratory fitness estimated (22-70 mL/kg/min). (frontiersin.org)
  • The male sex hormone testosterone may help women reduce body fat and build up muscle after the menopause, scientists say. (bbc.co.uk)
  • US researchers from Johns Hopkins University have shown for the first time that giving women a combination of testosterone and the female sex hormone oestrogen can help them stay healthier. (bbc.co.uk)
  • TUESDAY, Dec. 12, 2017 -- Yet again, the nation's leading authority on preventive medicine says postmenopausal women should avoid hormone replacement therapy, or HRT. (upi.com)
  • However, women undergoing menopause can use hormone replacement therapy short-term to treat symptoms such as hot flashes and vaginal dryness, said Dr. Suzanne Fenske, an assistant professor of obstetrics, gynecology and reproductive science with the Icahn School of Medicine at Mount Sinai in New York City. (upi.com)
  • Hormone replacement therapy does still have a benefit to women with menopause whose symptoms do not respond to other treatment options," Fenske said. (upi.com)
  • The task force first recommended against hormone replacement therapy for postmenopausal women in 2012. (upi.com)
  • Those women actually have adverse health consequences if they don't use hormone therapy at least until the natural age of menopause," Faubion said. (upi.com)
  • Fenske said women in menopause suffering from hot flashes, vaginal dryness and other related symptoms can still safely turn to hormone therapy to ease their discomfort. (upi.com)
  • Long-term hormone therapy for perimenopausal and postmenopausal women. (nih.gov)
  • Hormone therapy (HT) is widely provided for control of menopausal symptoms and has been used for the management and prevention of cardiovascular disease, osteoporosis and dementia in older women. (nih.gov)
  • For many women, hormone replacement therapy is not an option for menopause-related symptoms due to increased risks of cancer and heart disease, he noted. (psychcentral.com)
  • The authors also discussed why the thermoneutral zone is narrower in women with hot flashes and strategies for managing symptoms, including hormone therapy, medications that affect brain chemicals, and a method of breathing called paced respiration. (medindia.net)
  • Hormone Replacement Therapy can be likened to an oasis in the desert for women in the throes of menopause. (medindia.net)
  • This study is evaluating the effects of calcium supplementation on the efficacy and safety of recombinant parathyroid hormone (ALX1-11) in postmenopausal women with osteoporosis. (clinicaltrials.gov)
  • however, randomized clinical trials have shown that postmenopausal combination hormone therapy increases the risks for stroke, cardiovascular events, and breast cancer. (clinicaltrials.gov)
  • A Norwegian study was performed to assess the effects of a standardized ginseng extract compared with those of a placebo on quality of life and on hormone levels in symptomatic postmenopausal women. (healthy.net)
  • To assess the effectiveness of ginseng on postmenopausal symptoms, follicle-stimulating hormone (FSH), estradiol levels, and endometrial thickness, were recorded at the same time points. (healthy.net)
  • Newswise - ANAHEIM, Calif. - Blood hormone tests predicted a woman's risk for developing postmenopausal breast cancer for up to 20 years, according to data from the Nurses' Health Study presented at the 11th Annual AACR International Conference on Frontiers in Cancer Prevention Research, held here Oct. 16-19, 2012. (newswise.com)
  • Zhang and colleagues analyzed 796 patients with postmenopausal breast cancer who had not received hormone therapy. (newswise.com)
  • Women with hormone levels in the highest 25 percent for estradiol, testosterone and dehydroepiandrosterone sulfate (DHEAS) had a 50 percent to 107 percent greater chance for developing breast cancer compared with women in the lowest 25 percent. (newswise.com)
  • OBJECTIVE The effect of hormone replacement therapy on the risk of myocardial infarction in diabetic women has not been well studied. (diabetesjournals.org)
  • OBJECTIVE -The purpose of this study was to determine whether insulin sensitivity differs between postmenopausal women taking estradiol, women on estrogen plus progesterone hormone replacement therapy (HRT), and women not on HRT and whether differences are explained by the differences in total and/or abdominal adiposity and fat deposition in the muscle. (diabetesjournals.org)
  • Postmenopausal estrogen therapy and estrogen plus progesterone hormone replacement therapy (HRT) alleviate symptoms of menopause and attenuate bone loss ( 1 ). (diabetesjournals.org)
  • Nevertheless, a comparison of insulin sensitivity and concomitant characterization of total and visceral obesity and mid-thigh low-density lean tissue (a marker of intra-muscular fat) in women taking estrogen, taking estrogen plus progesterone, and not taking hormone therapy has not been conducted. (diabetesjournals.org)
  • In this study, we examined the relationship between pulse pressure and the progression of coronary atherosclerosis and the effects of hormone replacement therapy (HRT) on pulse pressure in postmenopausal women with angiographically confirmed coronary disease followed for 3.2 years in the Estrogen Replacement in Atherosclerosis (ERA) trial. (biomedsearch.com)
  • Objective To investigate the long term effect of hormone replacement therapy on cardiovascular outcomes in recently postmenopausal women. (bmj.com)
  • Participants 1006 healthy women aged 45-58 who were recently postmenopausal or had perimenopausal symptoms in combination with recorded postmenopausal serum follicle stimulating hormone values. (bmj.com)
  • 502 women were randomly allocated to receive hormone replacement therapy and 504 to receive no treatment (control). (bmj.com)
  • Women who had undergone hysterectomy were included if they were aged 45-52 and had recorded values for postmenopausal serum follicle stimulating hormone. (bmj.com)
  • Conclusions After 10 years of randomised treatment, women receiving hormone replacement therapy early after menopause had a significantly reduced risk of mortality, heart failure, or myocardial infarction, without any apparent increase in risk of cancer, venous thromboembolism, or stroke. (bmj.com)
  • Hormone replacement therapy for postmenopausal women has been subject to much discussion and speculation since the 1960s. (bmj.com)
  • A new study finds that up to seven years of hormone replacement therapy is safe for postmenopausal women. (latimes.com)
  • For decades now, women navigating menopause have been buffeted by shifting research findings on the risks and possible benefits of hormone-replacement therapy. (latimes.com)
  • In findings published Tuesday in the journal JAMA, women who were randomly assigned to take some form of hormone-replacement therapy for a median of six to seven years were no more, nor less, likely to die of any cause over the study's duration than were women who had been assigned to receive a placebo treatment. (latimes.com)
  • For women who enter menopause early, whose bones are at high risk of fracture, or who suffer menopause-related hot flashes, night sweats and sleep disruption, "hormone therapy appears to be both safe and efficacious," wrote McNeil, who directs the comprehensive women's health program at Pitt's general internal medicine division. (latimes.com)
  • The latest trial results compared the death rates of 13,531 women who were assigned to take a placebo treatment to those of menopausal women who got one of two different forms of hormone-replacement therapy: 8,506 women - mostly those with an intact uterus - were assigned to get a combination of estrogen and progestin, and 5,310 - most of whom had undergone hysterectomy - got estrogen alone. (latimes.com)
  • That statement - the product of a comprehensive review of research by NAMS leaders - concluded that for most women who initiate hormone replacement therapy under 60, or within 10 years of reaching menopause, it's safe and can improve quality of life, increase productivity and reduce medical expenditures linked to untreated symptoms of menopause. (latimes.com)
  • A team of US researchers has found that postmenopausal women, who are at the highest genetic risk of bone fracture, can benefit the most from hormone therapy. (topnews.in)
  • We found that women who are genetically at the highest fracture risk can enjoy the greatest protection from fracture when they use hormone therapy," said lead researcher Heather Ochs-Balcom at the University at Buffalo. (topnews.in)
  • The researchers investigated gene-hormone therapy interaction on fracture in postmenopausal white women and utilised the largest set of known genes linked to fracture risk from a meta-analysis of genome-wide association studies. (topnews.in)
  • The incidence of cardiovascular disease dramatically increases during menopause, and postmenopausal women seek natural alternatives to hormone therapy. (prohealth.com)
  • Some types of breast cancer are fuelled by the female sex hormone oestrogen. (cancerresearchuk.org)
  • A healthy 66-year-old woman has been taking combined continuous hormone therapy for menopausal symptoms for six months. (aafp.org)
  • In perimenopausal and postmenopausal women, is long-term, combined continuous hormone therapy safe and effective? (aafp.org)
  • Relatively healthy women taking combined continuous hormone therapy have higher risks of myocardial infarction and venous thromboembolism after one year, stroke after three years, and breast cancer after five years. (aafp.org)
  • In women who take hormone therapy continuously for five years, there is a lower incidence of fractures and colon cancer. (aafp.org)
  • In the past, based on the results of multiple small observational studies, the health benefits of long-term hormone therapy for perimenopausal and postmenopausal women were thought to be numerous. (aafp.org)
  • 2 The risk of venous thromboembolism was more than three times greater in women taking hormone therapy at one year, and the risk remained increased for more than five years. (aafp.org)
  • The National Institutes of Health-supported study, reported in JAMA Internal Medicine on June 24, 2013, looked at women taking conjugated equine estrogens, the most common type of postmenopausal hormone therapy in the United States. (nih.gov)
  • The earlier Women's Health Initiative Memory Study (WHIMS) linked the same type of hormone therapy to cognitive decline and dementia in older postmenopausal women. (nih.gov)
  • The WHIMS study found that estrogen-based postmenopausal hormone therapy produced deficits in cognitive function and increased risk for dementia when prescribed to women 65 and older," said NIA Director Richard J. Hodes, M.D. "Researchers leading the WHIMSY study wanted to expand on those results by exploring the possibility of a window of opportunity whereby hormone therapy might promote or preserve brain health when given to younger women. (nih.gov)
  • In contrast to findings in older postmenopausal women, this study tells women that taking these types of estrogen-based hormone therapies for a relatively short period of time in their early postmenopausal years may not put them at increased risk for cognitive decline over the long term," said Susan Resnick, Ph.D., chief of the Laboratory of Behavioral Neuroscience, in NIA's Intramural Research Program and a co-author of the study. (nih.gov)
  • Neither WHIMSY nor WHIMS was designed to assess the reasons that hormone treatments had different effects on cognition in older and younger postmenopausal women. (nih.gov)
  • The researchers found no meaningful difference in the average global cognitive function scores between women who had been assigned to hormone therapy vs. placebo. (nih.gov)
  • The WHIMSY research team will continue to follow the women in the study with annual telephone interviews to learn whether previous hormone therapy has longer term effects on how cognitive function changes over time. (nih.gov)
  • Women considering hormone therapy should consult their physician about how best to treat or prevent menopause symptoms or diseases for which they are at risk. (nih.gov)
  • 33%), postmenopausal women, ages 50-75 years, not using hormone therapy, living in the Seattle, Washington, area for the next year, and willing to be randomly assigned to an exercise intervention or stretching control group. (aacrjournals.org)
  • We conducted a randomized clinical trial to examine the effect of a 12-month moderate-intensity exercise intervention on serum estrone, estradiol, free estradiol, and SHBG in sedentary, overweight/obese postmenopausal women not taking hormone therapy. (aacrjournals.org)
  • The use of hormone replacement therapy (HRT) for prevention of cardiovascular disease in older postmenopausal failed to meet expectations. (mdpi.com)
  • SAN ANTONIO - Extended adjuvant endocrine therapy with letrozole improved DFS compared with placebo among postmenopausal women with hormone receptor-positive breast cancer who completed previous adjuvant therapy with an aromatase inhibitor, according to 10-year results from the randomized NRG Oncology/NSABP B-42 trial presented at San Antonio Breast Cancer Symposium. (healio.com)
  • The women were all in a 15-year study that was halted more than three years early in 2002 because of a clear link between the hormone replacement therapy (HRT) and the disease. (scientificamerican.com)
  • Despite the snowballing evidence linking hormone replacement therapy to breast cancer, many doctors continue to prescribe it for women with debilitating hot flashes and other symptoms of menopause. (scientificamerican.com)
  • The Food and Drug Administration (FDA) suggests that women with severe hot flashes consider hormone therapy, but recommends they take only the smallest doses for the shortest amount of time. (scientificamerican.com)
  • A domestic task force has recommended against menopausal women using hormone replacement therapy (HRT) to prevent potential future chronic disease. (newsinferno.com)
  • Effects of tibolone and continuous combined hormone replacement therapy on bleeding rates, quality of life and tolerability in postmenopausal women. (menopause.org.au)
  • A double-blind randomized trial comparing the effects of tibolone and continuous combined hormone replacement therapy in postmenopausal women with menopausal symptoms. (menopause.org.au)
  • There is conflicting information on the effects of oestrogen on the heart in women, especially those using postmenopausal hormone therapy. (wiley.com)
  • The aim of this study was to determine the effects of lifestyle and hormone therapy on heart function and structure in postmenopausal women. (wiley.com)
  • In the years following the WHI, studies have shown a decrease in breast cancer rates in postmenopausal women, attributed to the decline in use of hormone replacement therapy. (wikipedia.org)
  • However, concerns existed about the feasibility of such a complex clinical trial among participants in this demographic of older women, particularly with respect to sufficient recruitment and adherence to the dietary and hormone-treatment regimens. (wikipedia.org)
  • The trial followed 875 women who underwent treatment with estrogen, estrogen and progestin, or placebo, and - even quite early in the study - demonstrated both successful recruitment and participant retention/adherence in a hormone therapy (HT) setting. (wikipedia.org)
  • The main treatment for postmenopausal osteoporosis is estrogen replacement therapy (ERT). (hindawi.com)
  • Estrogen replacement therapy has been reported to have no effect on insulin sensitivity in postmenopausal women ( 14 , 15 , 16 ) and to improve carbohydrate metabolism in individuals with type 2 diabetes ( 17 , 18 ). (diabetesjournals.org)
  • Postmenopausal estrogen replacement therapy (ERT) is reported to increase angiotensin II under resting conditions. (ahajournals.org)
  • 1 Administration of exogenous estrogen to premenopausal women in contraceptive formulations 2 and to postmenopausal women as estrogen replacement therapy (ERT) 3 increases plasma concentrations of this renin substrate. (ahajournals.org)
  • An overview of the approach to therapy of osteoporosis in postmenopausal women will be presented here. (uptodate.com)
  • The diagnosis and evaluation of osteoporosis in postmenopausal women, the prevention of osteoporosis, and the management of osteoporosis in men and premenopausal women are discussed separately. (uptodate.com)
  • See 'Clinical manifestations, diagnosis, and evaluation of osteoporosis in postmenopausal women' . (uptodate.com)
  • It also has a marketing authorisation at a daily dose of 10 mg for the treatment of osteoporosis in postmenopausal women to prevent fractures. (nice.org.uk)
  • Eli Lilly) has marketing authorisation for the treatment of osteoporosis in postmenopausal women. (nice.org.uk)
  • April 9, 2019 -- The U.S. Food and Drug Administration today approved Evenity (romosozumab-aqqg) to treat osteoporosis in postmenopausal women at high risk of breaking a bone (fracture). (drugs.com)
  • As women go through the menopause there is a natural increase in fat. (bbc.co.uk)
  • Women live for an average of 30 years after the menopause, during which time their body fat is 20% higher than in women of child-bearing age. (bbc.co.uk)
  • Research has also found that women lose nearly 4% of muscle mass within the first three years of menopause. (bbc.co.uk)
  • Many women take oestrogens after menopause to combat symptoms like hot flushes and depression, but levels of male hormones, or androgens, which are present in low levels in women, also drop as women age. (bbc.co.uk)
  • The U.S. Preventive Services Task Force has stood by its original recommendation that women who have already gone through menopause should avoid using female hormones to guard against osteoporosis or diabetes. (upi.com)
  • The U.S. Preventive Services Task Force is standing by its original recommendation that women who have already gone through menopause should avoid using female hormones to guard against osteoporosis or diabetes, said task force chairman Dr. David Grossman , a senior investigator at the Kaiser Permanente Washington Health Research Institute in Seattle. (upi.com)
  • For example, the guideline does not apply to women who go through menopause early or prematurely, at age 45 or younger, Faubion said. (upi.com)
  • Because menopause marks the end of fertility , it may be difficult for women who want to have more children. (goodtherapy.org)
  • While some women develop panic during menopause, frequent panic attacks are not typical of menopause and may require medical treatment. (goodtherapy.org)
  • Some women may experience relief from anxiety when menopause ends and hormonal fluctuations are less frequent or severe. (goodtherapy.org)
  • The data, they say, suggest anxiety may significantly undermine quality of life as women enter menopause. (goodtherapy.org)
  • So could we them look back and see if these are women who have struggled with anxiety all their lives or is this something new that menopause itself could have triggered? (goodtherapy.org)
  • However, other differences in risk cannot be excluded, as this study was not designed to have the power to detect differences between groups of women within 10 years of menopause.For most studies, risk of bias was low in most domains. (nih.gov)
  • Hot flashes are well known to most menopausal women and to many who are in peri-menopause, the transition to menopause. (medindia.net)
  • Many educational and prevention programs about STDs are aimed at younger individuals, not women who have gone through menopause and their partners. (healthcentral.com)
  • Therefore, as HIV-positive women become estrogen deficient during menopause, they may be at higher risk for accelerated bone loss and fracture. (eurekalert.org)
  • Women are prone to tremendous estrogen reduction after menopause which will result in bone loss. (hindawi.com)
  • They studied the clinical histories of 534 women who, between 1989 and 2004, have attended periodically medical, laboratory and mammography tests at the Menopause Unit of the San Cecilio teaching Hospital of Granada. (innovations-report.com)
  • We studied 77 postmenopausal women with no history of osteoactive drug therapy, corticosteroid intake or diseases that could alter bone metabolism, attending the Menopause Center at the Hospital Provincial del Centenario, Rosario, Argentina. (scirp.org)
  • Founded in 1989, The North American Menopause Society (NAMS) is North America's leading nonprofit organization dedicated to promoting the health and quality of life of all women during midlife and beyond through an understanding of menopause and healthy aging. (eurekalert.org)
  • Women who have gone through menopause and who have been using a vaginal form of estrogen therapy do not have a higher risk of cardiovascular disease and cancer than women who have not been using any type of estrogen. (medicalnewstoday.com)
  • Whether these positive effects of supplemental calcium and vitamin D on cholesterol will translate into benefits such as lower rates of cardiovascular disease for women after menopause remains to be seen, but these results, said the authors, are a good reminder that women at higher risk for vitamin D deficiency should consider taking calcium and vitamin D. (nof.org)
  • Heart disease risk increases for everyone as they age, but for women, symptoms, if present, can become more evident after menopause.2 The average age of menopause for women is 51. (todaysdietitian.com)
  • An overall increase in heart attacks among women generally occurs about 10 years after menopause.2 Menopause itself doesn't cause heart disease, but risk factors such as obesity or physical inactivity are likely to have a greater impact as estrogen levels drop. (todaysdietitian.com)
  • Elsevier, a world-leading provider of scientific, technical and medical information products and services, announced today the publication of a position statement by the European Menopause and Andropause Society (EMAS) in journal Maturitas on the role of vitamin D in postmenopausal women with summary recommendations. (redorbit.com)
  • The menopause transition, as well as the early postmenopausal period, is associated with an increase in total and central obesity ( 7 , 8 , 9 ). (diabetesjournals.org)
  • That's especially true in women after menopause, when blood pressure may rise. (harvard.edu)
  • Members of the Spanish Menopause Society, Spanish Cardiology Society and Spanish Federation of Sports Medicine came together to draft recommendations on physical activity for older women and reviewed the quality of evidence for the various possible health benefits of exercise. (medicaldaily.com)
  • Decreased ovary function during menopause results in lower levels of circulating estrogen, which often leads to various symptoms such as hot flashes, night sweats, decreased cognitive functions and mood changes that are experienced by women during the years immediately preceding and during menopause ( Takahashi and Johnson, 2015 ). (frontiersin.org)
  • But a high number of large HDL particles was linked to an increased risk of heart disease when a woman was close to menopause. (medicaldaily.com)
  • According to a new study, supplementation with calcium and vitamin D does not appear to improve menopause-related vasomotor symptoms, mood changes, or sleep quality in postmenopausal women. (womensmentalhealth.org)
  • The US Food and Drug Administration (FDA) has approved a novel estrogen-based drug for women for the treatment of moderate-to-severe vasomotor symptoms and osteoporosis associated with menopause. (womensmentalhealth.org)
  • Women who have gone through menopause are more likely to get osteoporosis than other people. (cochrane.org)
  • Women who have gone through menopause may need to keep an eye on their cholesterol levels, according to new research from The Australian National University (ANU). (medicalxpress.com)
  • Our findings suggest that it might be important for women taking estrogen after menopause to also take androgen supplements - which can include testosterone," said Charles E. Wood, D.V.M., lead researcher, from Wake Forest University Baptist Medical Center . (news-medical.net)
  • Blood samples from the monkeys showed that androgen concentrations - both before and after menopause - were comparable to those found in women. (news-medical.net)
  • According to a CNN.com report this week, the U.S. Preventive Services Task Force has determined there are more risks than benefits to HRT when used by women who've already entered menopause but not to treat symptoms caused by the life stage such as hot flashes. (newsinferno.com)
  • The task force does not make the same assessment on HRT safety for women under the age of 50 or for women using estrogen, progestin, or both to treat common symptoms of menopause. (newsinferno.com)
  • The task force admits its recommendations are mostly for women experiencing menopause and that younger women may not be prone to the same risk factors if they're using HRT to prevent or control moderate or severe hot flashes. (newsinferno.com)
  • The average age of women analyzed by the previously conducted clinical trials was 64 years, almost a decade after they had entered menopause. (newsinferno.com)
  • Nonetheless, further research is needed to determine if these changes are primarily due to aging or changes in female sex hormones that occur at menopause. (natap.org)
  • Over the years, we've helped millions of women gain the knowledge they need to thrive during the menopause transition. (34-menopause-symptoms.com)
  • We encourage everyone to read and learn about menopause in order to achieve a healthy lifestyle and support the women in their lives. (34-menopause-symptoms.com)
  • More than 10 million people in the U.S. have osteoporosis, which is most common in women who have gone through menopause. (drugs.com)
  • We analyzed transiliac bone biopsies from a randomized, placebo-controlled clinical trial that evaluated the effects of risedronate treatment 5 mg/day on vertebral and non-vertebral fractures in women with postmenopausal osteoporosis. (springer.com)
  • The objective of this investigation was to develop a simple clinical assessment tool based on a small number of risk factors that could be used by women or their clinicians to assess their risk of fractures. (nih.gov)
  • Using data from the Study of Osteoporotic Fractures (SOF), a total of 7782 women age 65 years and older with bone mineral density (BMD) measurements and baseline risk factors were included in the analysis. (nih.gov)
  • The FRACTURE Index can be used either with or without BMD testing by older postmenopausal women or their clinicians to assess the 5-year risk of hip and other osteoporotic fractures, and could be useful in helping to determine the need for further evaluation and treatment of these women. (nih.gov)
  • In postmenopausal women with osteoporosis, lasofoxifene at a dose of 0.5 mg per day was associated with reduced risks of nonvertebral and vertebral fractures, ER-positive breast cancer, coronary heart disease, and stroke but an increased risk of venous thromboembolic events. (nih.gov)
  • Chevy Chase, MD-- According to a new study accepted for publication in The Endocrine Society's Journal of Clinical Endocrinology & Metabolism (JCEM), postmenopausal HIV-infected women have a high prevalence of low bone mineral density and high bone turnover placing them at high risk for future bone fractures. (eurekalert.org)
  • Although numbers of HIV-infected postmenopausal women are increasing and postmenopausal women are at highest risk for osteoporotic fractures, few studies have evaluated skeletal status in this group. (eurekalert.org)
  • Outcomes included the percentage of osteoporotic fractures and the rates of fracture and excess fracture (per 1000 person-years) among postmenopausal women with osteopenia and osteoporosis relative to those with normal bone mineral density (according to the classification of the World Health Organization). (cmaj.ca)
  • In this study, most of the postmenopausal women with osteoporotic fractures had nonosteoporotic bone mineral density values. (cmaj.ca)
  • Population-based data on the percentage of fractures that occur in postmenopausal women with either normal bone mineral density or osteopenia are limited. (cmaj.ca)
  • Stone and colleagues, 6 in a secondary data analysis of 9704 women over 65 years of age, reported that total hip bone mineral density was more strongly correlated with most fractures than were lumbar spine or peripheral bone mineral density measurements. (cmaj.ca)
  • 6 Siris and collaborators, 7 in a cohort of 149 524 women over 50 years of age, used peripheral bone mineral density to determine the association between osteopenia and self-reported fractures. (cmaj.ca)
  • The prevalence of osteoporosis (T-score -2.5 or less) was 6.4% among the women with fractures, and 18% of all fractures occurred in these women. (cmaj.ca)
  • Osteoporosis is a common condition in postmenopausal women leading to bone fractures. (redorbit.com)
  • As women age, their Bone Mineral Density (BMD) decreases, leaving them at greater risk of breaking bones from falling, which also increases as they age as some women are also more genetically prone to fractures. (topnews.in)
  • To assess the efficacy of residronate in the primary and secondary prevention of osteoporotic fractures in postmenopausal women. (cochrane.org)
  • Loss of height is usually recorded as one of the clinical signs to help identify postmenopausal women with vertebral fractures. (cmaj.ca)
  • Procter & Gamble UK) is an oral bisphosphonate that has a UK marketing authorisation at a dosage of 5 mg/day or 35 mg/week for the treatment of postmenopausal osteoporosis, to reduce the risk of vertebral fractures, and for the treatment of established postmenopausal osteoporosis, to reduce the risk of hip fractures. (nice.org.uk)
  • The approval of Prolia provides another treatment option for postmenopausal women with osteoporosis who are susceptible to fractures. (healthcanal.com)
  • In the study, Prolia reduced the incidence of vertebral, non-vertebral, and hip fractures in postmenopausal women with osteoporosis. (healthcanal.com)
  • This explains the fact that about 80% of the economic burden of osteoporosis has been attributed to its occurrence in women, especially in postmenopausal women [ 11 ]. (hindawi.com)
  • Previous research in humans and rodents has indicated that dietary dried plum consumption may be beneficial for bone health, especially in postmenopausal women. (clinicaltrials.gov)
  • However, the underlying mechanisms are not fully understood and need to be investigated, especially in postmenopausal women, who are at increased risk of age-related disorders such as Alzheimer's disease and stroke. (frontiersin.org)
  • The average age of women in the diet drink study was 62.8, and they had to have had no history of cardiovascular disease to be included in the analysis. (reuters.com)
  • Among women with cardiovascular disease, use of combined continuous HT significantly increased the risk of venous thromboembolism (at 1 year's use: from 3 per 1000 to between 3 and 29 per 1000). (nih.gov)
  • Cardiovascular disease is the leading cause of death and disability in postmenopausal women older than 50 years. (aafp.org)
  • Increased visceral fat is associated with insulin resistance ( 10 ), and this preferential storage of abdominal fat may contribute to cardiovascular disease and diabetes in postmenopausal women. (diabetesjournals.org)
  • The association between magnesium and a reduced risk for cardiovascular disease was attenuated in the fully adjusted model, with an HR of 1.19 (95% CI, 1.06-1.34) for CHD and an HR of 1.24 (95% CI, 0.58-2.65) for SCD among women in the lowest quartile of magnesium intake. (healio.com)
  • It also has been used for the management and prevention of cardiovascular disease, osteoporosis, and dementia in older women, but the evidence supporting its use for these indications is largely observational. (aafp.org)
  • The aim of this double-blind, placebo-controlled clinical study was to investigate the effect of an isoflavonoid-rich herbal preparation on atherosclerosis progression in postmenopausal women free of overt cardiovascular disease. (mdpi.com)
  • These levels can put some women at higher risk of cardiovascular disease such as heart disease and stroke. (medicalxpress.com)
  • Cardiovascular disease remains the leading cause of illness and death in women. (womenshealthmatters.ca)
  • Study participants are postmenopausal women (n= 90,168) who are free of cardiovascular disease at baseline, evaluated from 1993-1998. (ahajournals.org)
  • Among postmenopausal women, cardiovascular disease, cancer, and osteoporosis are the leading causes of morbidity and mortality, as well as impaired quality of life. (wikipedia.org)
  • Among women in all age groups, cancer and cardiovascular disease are the leading causes of mortality. (wikipedia.org)
  • In 1990, however, interest in the impact of diet on cancer and cardiovascular disease in women was renewed, and a joint National Cancer Institute (NCI)-National Heart, Lung, and Blood Institute (NHLBI) workshop concluded that a full-scale dietary trial, with a focus on these two diseases, was warranted. (wikipedia.org)
  • While those findings will probably reassure women who have avoided taking replacement hormones for menopausal symptoms, they are likely as well to temper claims that HRT can help women reduce their risk of certain diseases and prolong life. (latimes.com)
  • The panel said there is no evidence that using HRT in women with no menopausal symptoms has not proven effective in the prevention of those diseases. (newsinferno.com)
  • Researchers followed a cross-sectional sample of 3,503 postmenopausal Latin American women. (goodtherapy.org)
  • The multicenter, cross-sectional study of 3,503 postmenopausal Latin American women specifically showed that the prevalence of severe physical symptoms in postmenopausal women with anxiety was five times higher than that observed among those without anxiety. (eurekalert.org)
  • But this study, led by NAMS Board of Trustees member Peter F. Schnatz, DO, NCMP, is helping to settle those questions because it looked both at how a calcium and vitamin D supplement changed cholesterol levels and how it affected blood levels of vitamin D in postmenopausal women. (nof.org)
  • These women were then monitored over a 26-year period, during which time 91 women developed postmenopausal breast cancer. (eurekalert.org)
  • Interventions In the treatment group, women with an intact uterus were treated with triphasic estradiol and norethisterone acetate and women who had undergone hysterectomy received 2 mg estradiol a day. (bmj.com)
  • A related study of the same group of women showed a significant increase in bone density, without adverse health effects, in the women who took estradiol compared to the women who took placebo. (rxpgnews.com)
  • In contrast, the women studied by Yaffe and her associates received a daily dose of estradiol - pure human estrogen - that was over 44 times smaller and delivered through a skin patch. (rxpgnews.com)
  • Compare the safety, acceptability, and adherence to letrozole vs placebo in postmenopausal women at increased risk for the development or recurrence of breast cancer based on elevated plasma estradiol levels. (knowcancer.com)
  • The effect was limited to women who lost body fat: women whose percentage of body fat [by dual energy x-ray absortiometry (DEXA)] decreased by ≥2% had statistically significant (comparing exercisers versus controls) decreases at 12 months of 11.9, 13.7, and 16.7% for serum estrone, estradiol, and free estradiol, respectively. (aacrjournals.org)
  • We studied 13 normotensive postmenopausal women (54±2 [mean±SE] years) before and after 1 month of oral estradiol 2 mg daily, and 14 premenopausal women. (ahajournals.org)
  • Renin, aldosterone, and HR responses to LBNP (which tended to be less in postmenopausal women [ P =0.06]) were not affected by estradiol. (ahajournals.org)
  • Hence, Tualang honey can be used as an alternative treatment of postmenopausal osteoporosis with minimal side effects. (hindawi.com)
  • 3.2 Alendronate is an oral bisphosphonate that has a UK marketing authorisation as a once-weekly preparation (70 mg) for the treatment of postmenopausal osteoporosis. (nice.org.uk)
  • The safety and efficacy of Prolia in the treatment of postmenopausal osteoporosis was demonstrated in a three-year, randomized, double-blind, placebo-controlled trial of 7,808 postmenopausal women ages 60 to 91 years. (healthcanal.com)
  • In the Women's Health Initiative Observational Study, a prospective cohort of postmenopausal women, 73,737 women without previous breast cancer were followed. (aacrjournals.org)
  • We examined the association between self-reported periodontal disease history and breast cancer risk in the Women's Health Initiative Observational Study (WHI OS), a large prospective cohort of postmenopausal women in the United States. (aacrjournals.org)
  • The purpose of the current study was to evaluate the associations between AR expression and survival outcomes in a large cohort of postmenopausal women with stage I to III breast cancer identified from the Nurses' Health Study (NHS), and to assess this association stratified by ER status as well as in the triple-negative subtype of breast cancer. (aacrjournals.org)
  • This study evaluated prospectively the association between history of asthma and CVD in a cohort of postmenopausal women. (ahajournals.org)
  • Therefore, the purpose of this study is to evaluate the impact of 52 weeks of dried plums consumption in varying quantities on bone mineral density (BMD), bone geometry, and estimated bone strength in postmenopausal women. (clinicaltrials.gov)
  • Does creatine improve strength in postmenopausal women? (sun-sentinel.com)
  • Here we sought to compare the vaginal microbiomes of postmenopausal women who received low dose estrogen therapy to those of premenopausal and postmenopausal women, and to do so in conjunction with assessing the alleviation of symptoms associated with vaginal atrophy. (frontiersin.org)
  • 2010) Calcium Status in Premenopausal and Postmenopausal Women. (scirp.org)
  • All of the women in the study had previously been on oestrogen replacement therapy for three months or longer. (bbc.co.uk)
  • WASHINGTON (Reuters) - Diet drinks may increase the risk of heart attacks, stroke and other heart problems in postmenopausal women, according to an informal study that could take some fizz out of enjoyment of the popular beverages. (reuters.com)
  • The findings were gleaned from an analysis of diet drink intake and consequences among almost 60,000 participants in the Women's Health Initiative, a long-running U.S. observational study of cardiovascular health trends among postmenopausal women. (reuters.com)
  • According to the Breast Cancer Campaign study, women at or below normal weight are more likely to benefit from vigorous exercise than their overweight counterparts. (netdoctor.co.uk)
  • Their six-to-seven year study, involving thousands of women from the Women's Health Initiative, found that patients who had been prescribed certain types of statins had a 48% higher chance of subsequently being diagnosed with diabetes, compared to their counterparts who were not on those medications. (medicalnewstoday.com)
  • The researchers worked out that the participants who had been on statins had a 48% higher risk of developing diabetes compared to the other women in their study. (medicalnewstoday.com)
  • The present study aimed to assess the metabolic syndrome among postmenopausal women in Gorgan, Iran. (hindawi.com)
  • The study was conducted on hundred postmenopausal women who were referred to the health centers in Gorgan. (hindawi.com)
  • Our study also showed some related factors of metabolic syndrome among postmenopausal women. (hindawi.com)
  • The study also found women who experience anxiety are more likely to experience physical health ailments , such as hot flashes and pain in muscles and joints. (goodtherapy.org)
  • Anxiety takes toll on postmenopausal women: Study. (goodtherapy.org)
  • In this study, we demonstrate that risedronate prevents marrow fat infiltration in postmenopausal women after 3 years of treatment. (springer.com)
  • A new study has found that hypnotic relaxation therapy can improve sexual health in postmenopausal women who have moderate to severe hot flashes. (psychcentral.com)
  • For the study, 187 women were randomly assigned to receive either five weekly sessions of hypnotic relaxation therapy or supportive counseling. (psychcentral.com)
  • Women completed questionnaires at the beginning of the study, at the end of treatment, and at a 12-week follow-up. (psychcentral.com)
  • Women whose data were considered for the study could walk at least one block and did not have heart failure, coronary artery disease or cancer. (upi.com)
  • The women self reported their walking behavior and health outcomes for the duration of the study. (upi.com)
  • Fifty-five postmenopausal women with depression symptoms, who were not in use of hormones or antidepressants, were included in the study. (nature.com)
  • A new study by researchers at NYU Langone Medical Center and colleagues found that traditional risk factors for stroke - such as high cholesterol - are not as accurate at predicting risk in postmenopausal women as previously thought. (innovations-report.com)
  • This study revealed that what we've been using to evaluate risk all these years actually has little to no predictive value in older women. (innovations-report.com)
  • The researchers analyzed data from the Hormones and Biomarkers Predicting Stroke (HaBPS) study, consisting of women enrolled in the Women's Health Initiative (WHI), a landmark National Institutes of Health-sponsored study that has monitored the health of more than 90,000 postmenopausal women nationwide for more than 15 years. (innovations-report.com)
  • In fact, women in the highest quarter of baseline triglyceride levels were nearly twice as likely to have suffered an ischemic stroke as women in the lowest quarter of triglyceride levels during the course of the study. (innovations-report.com)
  • To test their hypothesis, Yin and his colleagues initiated a longitudinal study to assess bone health in 92 HIV-positive and 95 HIV-negative postmenopausal women. (eurekalert.org)
  • This study examined bone density among postmenopausal Buddhist nuns and female religious followers of Buddhism in southern Taiwan and related the measurements to subject characteristics including age, body mass, physical activity, nutrient intake, and vegetarian practice. (springer.com)
  • A total of 258 postmenopausal Taiwanese vegetarian women participated in the study. (springer.com)
  • This phase 3a study is designed to assess the safety and efficacy of MF101 on the frequency of moderate to severe hot flushes in postmenopausal women. (clinicaltrials.gov)
  • Women without language barrier, cooperative expected to return for all follow-up procedures and who have given informed consent before entering the study and after being informed of the risks, medications, and procedures to be used in the study. (clinicaltrials.gov)
  • The study objectives were to determine fracture rates in relation to bone mineral density at various central skeletal sites, using the World Health Organization definition for osteoporosis (T-score -2.5 or less), and to contrast fracture patterns among women 50 to 64 years of age with those among women 65 years of age and older. (cmaj.ca)
  • The study group (16 505 women 50 years of age or older) was drawn from the Manitoba Bone Density Program database, which includes all bone mineral density results for Manitoba. (cmaj.ca)
  • In this retrospective cohort study, we examined records for 16 505 women 50 years of age or older who underwent baseline bone mineral densitometry of the lumbar spine (first through fourth lumbar vertebrae) and the proximal femur (total hip, femoral neck and trochanter) between May 1998 and October 2002. (cmaj.ca)
  • Now a new study documents the same association in postmenopausal women. (eurekalert.org)
  • The article, "Association between anxiety and severe quality-of-life impairment in postmenopausal women: analysis of a multicenter Latin American cross-sectional study," reports on the first study that specifically addresses the association between anxiety and quality of life in postmenopausal women. (eurekalert.org)
  • Women with the highest bone mass are at a much greater risk of postmenopausal breast cancer than those with lower bone mass, according to the results of a long-term epidemiological study supported by the National Institutes of Health (NIH). (eurekalert.org)
  • The study examined 1,373 women who received hand x-rays between 1967 and 1970 as part of the NHLBI's Framingham Heart Study, an ongoing epidemiological study in Framingham, Massachusetts. (eurekalert.org)
  • The Postmenopausal Estrogen/Progestin Interventions Trial (PEPI), an NHLBI-administered study, found that HRT helps improve some heart disease risk factors. (eurekalert.org)
  • For postmenopausal women who need to make treatment decisions now, before ongoing study results are available, Dr. Lenfant advised women to consult their physicians and weigh their individual health risks before deciding on the best course of action. (eurekalert.org)
  • The results of this study should inspire even more women to be conscientious about their calcium and vitamin D intake-a simple and safe way to improve health. (nof.org)
  • We conducted a case-control study of postmenopausal estrogen use and risk of incident myocardial infarction (MI) in pharmacologically treated diabetic women enrolled at Group Health Cooperative of Puget Sound, a large health maintenance organization in the state of Washington. (diabetesjournals.org)
  • CONCLUSIONS This study suggests that use of postmenopausal estrogens does not increase risk of MI in diabetic women and that sustained use may be of benefit. (diabetesjournals.org)
  • The presence of saturated fatty acids in the breast tissue may be a useful indicator of cancer in postmenopausal women, says a new study published in the journal Radiology . (medindia.net)
  • Introduction: Pelvic floor muscle function of 30 overweight postmenopausal women prior to and after colporrhahpy was monitored in this study. (scirp.org)
  • 1999) Prevalence of Urinary Incontinence and Associated Risk Factors in Postmenopausal Women: Heart and Estrogen/Progestin Replacement Study (HERS) Research Group. (scirp.org)
  • For example, a recent case-control study of both pre- and postmenopausal women found that a higher intake of meat was associated with an increase of CHD, but only in smokers.7 The same may be true of any other risk factor, ie, the impact of any one risk factor may depend on the presence of one or more additional risk factors. (todaysdietitian.com)
  • The article is "Teriparatide Accelerates Lumbar Posterolateral Fusion in Postmenopausal Women With Osteoporosis: Prospective Study. (spineuniverse.com)
  • In the study, there were 57 postmenopausal women with osteoporosis . (spineuniverse.com)
  • This study showed that in postmenopausal women with osteoporosis who undergo instrumented lumbar posterolateral fusion,daily subcutaneous injections of teriparatide provide better bone union rates than weekly oral administration of bisphosphonate. (spineuniverse.com)
  • Teriparatide Accelerates Lumbar Posterolateral Fusion in Postmenopausal Women With Osteoporosis: Prospective Study [published online ahead of print August 6, 2012]. (spineuniverse.com)
  • In a 2003 Canadian study of men and women ages 65 and over participating in a six-month strength-training program, those who took creatine had a twofold increase in lean muscle mass compared with a placebo group. (sun-sentinel.com)
  • In a small European study published in 2008, creatine seemed to confer a short-term benefit on postmenopausal women. (sun-sentinel.com)
  • At the start of the study, the women were evaluated for muscle performance (bench press, hand grip, tandem walking, and leg press). (sun-sentinel.com)
  • Findings from a new study could help more women to overcome breast cancer. (medicaldaily.com)
  • In this study vaginal swab samples were obtained from 45 women who were classified as either premenopausal, postmenopausal, or postmenopausal and undergoing HT. (frontiersin.org)
  • The vaginal communities of women in each study group differed in terms of the dominant bacterial species composition and relative abundance. (frontiersin.org)
  • This association varied substantially by WHI study region with hazard ratios for women living (healthpartners.com)
  • The study included nearly 10,000 participants from the Women's Health Initiative (WHI), a national, long-term study of more than 1,50,000 women. (topnews.in)
  • By University of California - San Francisco, A study led by researchers at the San Francisco VA Medical Center has shown that extremely low doses of estrogen had no ill effects on the cognitive abilities or general health of older women over the course of two years. (rxpgnews.com)
  • In 2004, study results from the Women's Health Initiative (WHI), a nationwide longitudinal study sponsored by the National Institutes of Health, indicated that estrogen was associated with an increased risk of dementia among women 65 and older, as well as with an increased risk of heart attack and stroke. (rxpgnews.com)
  • The women were given a battery of standardized cognitive tests and a test of health-related quality of life at the beginning of the study, after one year, and after two years. (rxpgnews.com)
  • The study titled "HDL (High-Density Lipoprotein) Metrics and Atherosclerotic Risk in Women" was published in the journal Arteriosclerosis, Thrombosis, and Vascular Biology on July 19. (medicaldaily.com)
  • This study confirms our previous work on a different group of women and suggests that clinicians need to take a closer look at the type of HDL in middle-aged and older women, because higher HDL cholesterol may not always be as protective in postmenopausal women as we once thought," she said . (medicaldaily.com)
  • Goldberg, who was not involved in the study, also encouraged regular exercise as an effective way to improve cholesterol levels, especially in older women. (medicaldaily.com)
  • In this study, women with schizophrenia were treated with estrogen in addition to their antipsychotic medications. (womensmentalhealth.org)
  • In a study including Latin American women 40 to 59 years of age who had not menstruated for more than 1 year (or had undergone a bilateral oophorectomy), 49.1% of the participants were depressed and 61.9% reported anxiety symptoms. (womensmentalhealth.org)
  • 2003) Effect of Short-Chain Fructooligosaccharides on Intestinal Calcium Absorption and Calcium Status in Postmenopausal Women: A Stable-Isotope Study. (scirp.org)
  • However, according to the WHI study, after five years of taking the medication, the absolute risk of venous thromboembolism for women 50 to 59 years of age was 0.5 percent for women of normal weight and 1.4 percent for women who were obese. (aafp.org)
  • Treating postmenopausal women with osteoporosis with twice-yearly injections of a new drug, denosumab, significantly decreases their risk of suffering a fracture, latest study results suggest. (nursingtimes.net)
  • The new findings come from the Women's Health Initiative Memory Study of Younger Women (WHIMSY) trial and were reported by Mark A. Espeland, Ph.D., Wake Forest School of Medicine, Winston-Salem, N.C., on behalf of the academic research centers involved in the study. (nih.gov)
  • The epidemiological study of women with urinary incontinence and risk factors for stress urinary inc. (biomedsearch.com)
  • This study in 381postmenopausal women, however, revealed just the opposite. (cancernetwork.com)
  • The researchers foundthat women in the study who ate less fat than is typical among US women actuallyhad higher levels of estrogen in their blood, making it unlikely that eating alow-fat diet will lead to lower levels of estrogen. (cancernetwork.com)
  • Researchersalso estimated the different kinds of fat the women ate, based on a food surveyconducted twice during the 4-year study. (cancernetwork.com)
  • A total of 170 (98.3%) women completed the study with exercisers averaging 171 min/week of exercise. (aacrjournals.org)
  • Dr. Bahram H. Arjmandi of Florida State said the study was the first to evaluate the long-term cardioprotective effects of apple in postmenopausal women. (ausfoodnews.com.au)
  • The study randomly assigned 160 women between 45-65 years of age to one of two dietary intervention groups: one received dried apples daily (75g/day for 1 year) and the other group ate dried prunes every day for a year. (ausfoodnews.com.au)
  • The study was performed at a single trial site in Australia and enrolled 39 postmenopausal women aged 50 to 85 (mean age of 63 years). (cnbc.com)
  • In an observational study conducted between December 2007 and May 2008, we asked 1779 randomly selected general practitioners to recruit the first five female patients who were more than 60 years of age, regardless of the reason for the consultation. (cmaj.ca)
  • We conducted this study to compare reported and measured loss of height in a large population of women more than 60 years old in a primary care setting and to analyze the determinants of this height loss. (cmaj.ca)
  • Washington - A new study has found that postmenopausal women who consumed sugar-sweetened beverages were more likely to develop endometrial cancer compared with women who did not drink such beverages. (indiavision.com)
  • Although ours is the first study to show this relationship, it is not surprising to see that women who drank more sugar-sweetened beverages had a higher risk of estrogen-dependent type I endometrial cancer but not estrogen-independent type II endometrial cancer," said lead author Maki Inoue-Choi, research associate in the Division of Epidemiology and Community Health of the University of Minnesota School of Public Health in Minneapolis, said. (indiavision.com)
  • Inoue-Choi and colleagues used data from 23,039 postmenopausal women who reported dietary intake, demographic information, and medical history in 1986, prior to the cancer diagnosis, as part of the Iowa Women's Health Study. (indiavision.com)
  • The author comments on a study by Karen H. Lu et al and published in a 2013 issue of "Cancer," which found the effectiveness of an ovarian cancer screening strategy that incorporates a CA-125 blood test and Risk of Ovarian Cancer Algorithm calculation in identifying ovarian cancer early in postmenopausal women. (ebscohost.com)
  • MATERIAL AND METHODS A case-control study of 93 women was designed*36. (ebscohost.com)
  • The article presents a case study of a 63-year-old woman with extra-ovarian primary peritoneal papillary serous carcinoma (EOPPC) (Stage IV) diagnosis by clinical appearance. (ebscohost.com)
  • The article focuses on a study published in the periodical "Journal of Obstetrics and Gynecology" on August 5, 2015m, as per which, women diagnosed early with low-grade ovarian tumor have longer survival rates and mentions symptoms of ovarian cancer including persistent abdominal bloating. (ebscohost.com)
  • This study shows postmenopausal women should check their LDL levels and see if they are at risk. (medicalxpress.com)
  • In the postmenopausal phase of the study, treatment with soy plus Premarin resulted in DHEA-S levels that were 29 percent lower than the monkeys who ate soy without isoflavones (control group) and 35 percent lower than the group eating soy with isoflavones. (news-medical.net)
  • In a retrospective cross-sectional study among 202 postmenopausal women aged 46-75 years, we aimed to investigate the relationship between body composition and bone mineral density (BMD) to determine whether fat mass or lean mass is a better determinant of BMD in Turkish postmenopausal women. (unboundmedicine.com)
  • Researchers, however, abruptly stopped the study after finding that it did not guard against heart disease and that there was a 26 percent higher risk of breast cancer among the women taking hormones. (scientificamerican.com)
  • The study is based on the findings of nine previously finished clinical trials and although the findings that HRT is not effective in the prevention of future disease, the new report is designed to present some clarity to women who may still be using both hormones for these indications. (newsinferno.com)
  • About a decade ago, according to the report, a wide-ranging study known as Women's Health Initiative put an almost complete halt to using HRT in this way as it was proving to have no clinical benefits and was actually putting women at greater risk of harm from the conditions the hormones were supposed to be preventing. (newsinferno.com)
  • It was a prospective study of postmenopausal women enrolled in the Nurses' Health Study with stage I to III breast cancer diagnosed between 1976 and 1997 and followed from the date of diagnosis until January 1, 2008 or death. (aacrjournals.org)
  • The NHS is a prospective cohort study established in 1976 when 121,700 female registered nurses from across the United States, aged 30 to 55 years, completed a mailed questionnaire on factors that influence women's health. (aacrjournals.org)
  • One uncontrolled English study has suggested that tibolone increases breast cancer risk but better quality placebo controlled randomised trials do not show that breast cancer rates in healthy women are changed by tibolone [5]. (menopause.org.au)
  • As part of a large longitudinal study of women randomly recruited from an urban population, the study assessed 410 suitable women by echocardiography in Year 1 and Year 5 of the study by two independent cardiologists. (wiley.com)
  • In its entirety, the WHI enrolled more than 160,000 postmenopausal women aged 50-79 years (at time of study enrollment) over 15 years, making it one of the largest U.S. prevention studies of its kind, with a budget of $625 million. (wikipedia.org)
  • To further promote the study of women, in 1990, the NIH created the Office of Research on Women's Health. (wikipedia.org)
  • The WHT did not proceed with its full-scale trial, as it was not awarded further funding from the NIH on the basis of the potential inability of the study to test the hypothesis in a larger cohort of women. (wikipedia.org)
  • While many postmenopausal women might find it difficult to partake in vigorous exercise as they attempt to reduce their risk of breast cancer , they can still help their cause by embarking on a more moderate exercise regime, it has been claimed. (netdoctor.co.uk)
  • Research published in Breast Cancer Research recently suggests there is a link between physical activity and a reduction in postmenopausal breast cancer risk. (netdoctor.co.uk)
  • Statin medication use in postmenopausal women is associated with an increased risk for diabetes mellitus. (medicalnewstoday.com)
  • These factors may increase cardiovascular risk among postmenopausal women with metabolic syndrome. (hindawi.com)
  • The only significantly increased risk reported was for venous thromboembolism in women taking combined continuous HT: Their absolute risk remained low, at less than 1/500. (nih.gov)
  • Women who engaged only in moderate but not vigorous physical activity also benefited, with moderate activity as infrequently as once per week demonstrating a reduced mortality risk of 0.78 (95% CI, 0.64-0.96). (nih.gov)
  • Women walking at least twice a week had a 20 percent to 25 percent lower risk of heart failure than those who walked less frequently. (upi.com)
  • And women who walked at an average rate had a 26 percent lower risk than those walking at a casual pace. (upi.com)
  • We actually looked at women with four different categories of body mass index and found the same inverse relationship between walking behavior and the risk of heart failure," Rasla said. (upi.com)
  • The results show that even obese and overweight women can still benefit from walking to decrease their risk of heart failure. (upi.com)
  • Postmenopausal women may be at higher risk of having a stroke than they think. (innovations-report.com)
  • Instead, researchers say doctors should refocus their attention on triglyceride levels to determine which women are at highest risk of suffering a devastating and potentially fatal cardiovascular event. (innovations-report.com)
  • Major guidelines concur that women at average risk of breast cancer benefit from screening mammography at least every other year from 50 to 74 years of age. (aafp.org)
  • Clinicians should consider screening for sexually transmitted infections in older women at high risk. (aafp.org)
  • Women at high risk of sexually transmitted infections should receive intensive behavioral counseling and screening. (aafp.org)
  • Do not screen for ovarian cancer in asymptomatic women at average risk. (aafp.org)
  • Do not screen low-risk women with cancer antigen 125 or ultrasonography for ovarian cancer. (aafp.org)
  • Do not perform screening for cervical cancer in low-risk women 65 years or older or in women who have had a total hysterectomy for benign disease. (aafp.org)
  • Do not screen women older than 65 years for cervical cancer who have had adequate prior screening and are not otherwise at high risk of cervical cancer. (aafp.org)
  • Identification of effective nutrition supplements may be necessary to improve BMD levels and to reduce the risk of osteoporosis among long-term female vegetarians. (springer.com)
  • After adjusting for multiple breast cancer risk factors, researchers determined that women in the highest bone mass group had 3.5 times the risk of getting breast cancer compared to those in the lowest quartile of bone mass. (eurekalert.org)
  • Randomized trials and other studies have shown that women who take estrogen therapy in the form of a pill may have an increased risk of blood clots, stroke and if the estrogen is used together with progestogen pills, invasive breast cancer. (medicalnewstoday.com)
  • Women in the highest 25 percent of SHBG levels had a 30 percent lower risk for breast cancer compared with women in the lowest 25 percent for SHBG levels. (newswise.com)
  • While increased BMI may provide a protective effect for premenopausal women, postmenopausal women have an increased risk of developing breast cancer with increasing BMI. (medindia.net)
  • The exact mechanism behind the increased risk in postmenopausal women with higher BMI is not fully understood. (medindia.net)
  • Even if a woman is symptom-free, she still may be at risk of heart disease. (todaysdietitian.com)
  • Non-pharmacologic options to reducing the risk of bone loss are becoming more attractive to many postmenopausal women. (clinicaltrials.gov)
  • Millions of American women have soaring blood pressure that's putting their health at serious risk. (harvard.edu)
  • Our understanding of the etiology and risk factors for fatal coronary heart disease and sudden cardiac death, particularly among women, is limited," Jason Li, DO, MS, of the department of family medicine at Alpert Medical School of Brown University, and colleagues wrote. (healio.com)
  • Being obese increases the risk of postmenopausal breast cancer by up to 30 per cent and more than 4,000 cases of breast cancer each year in the UK are linked to excess bodyweight. (cancerresearchuk.org)
  • But as we know that having a high BMI can contribute to an increased risk of both type II diabetes and breast cancer, it makes sense for women to try and maintain a healthy weight. (cancerresearchuk.org)
  • Loss of all natural teeth is associated with a 17% higher risk of death from any cause in postmenopausal women, claim researchers. (hindustantimes.com)
  • The findings showed that women with a history of periodontal disease had a 12% higher risk of death from any cause. (hindustantimes.com)
  • Our findings suggest that older women may be at higher risk for death because of their periodontal condition and may benefit from more intensive oral screening measures," said Michael J. LaMonte, associate professor at the University at Buffalo, US. (hindustantimes.com)
  • We know that the risk of the disease can be affected by family history and getting older, but there are also things women can do help reduce the risk of the disease. (cancerresearchuk.org)
  • Circulating sex hormones and breast cancer risk factors in postmenopausal women: reanalysis of 13 studies. (cancerresearchuk.org)
  • A randomized clinical trial of estrogen therapy in younger postmenopausal women, aged 50-55, has found no long-term risk or benefit to cognitive function. (nih.gov)
  • It has long been thought that dietary fat canincrease production of sex hormones, including estrogen, and thus put women(especially older women) at risk for breast cancer. (cancernetwork.com)
  • The association between increased physical activity and reduced risk for postmenopausal breast cancer may be partly explained by effects on serum estrogens. (aacrjournals.org)
  • Although not proven, a reasonable hypothesis is that reduction of circulating postmenopausal estrogen concentrations would lower breast cancer risk. (aacrjournals.org)
  • Postmenopausal women who reported the highest intake of sugar-sweetened beverages had a 78 percent increased risk for estrogen-dependent type I endometrial cancer. (indiavision.com)
  • This association was found in a dose-dependent manner: the more sugar-sweetened beverages a woman drank, the higher her risk. (indiavision.com)
  • WASHINGTON, D.C. - Scientists at the University of Texas at Austin have identified pathways by which a reduced-calorie diet and exercise can modify a postmenopausal woman's risk of breast cancer. (massagemag.com)
  • Epidemiological data has suggested that inducing a so-called "negative energy balance" (where less energy is taken in than expended) through eating a low-calorie diet or increasing exercise levels, decreases the postmenopausal breast cancer risk associated with obesity. (massagemag.com)
  • LDL profiles vary for all women, depending on their risk factors. (medicalxpress.com)
  • Periodontal disease, a common chronic inflammatory disorder, was associated with increased risk of postmenopausal breast cancer, particularly among former smokers who quit in the past 20 years. (aacrjournals.org)
  • But the good news is that the risk dips when the women go off the drugs. (scientificamerican.com)
  • the risk dipped when the women stopped taking the pills, decreasing to normal levels two years after they went off them. (scientificamerican.com)
  • However, no link was observed between breast cancer risk and physical activity in women who were active at a younger age. (bio-medicine.org)
  • Little is known about the specific effects of aging on immunologic mechanisms that may put mature women at increased risk for HIV. (natap.org)
  • This risk is mainly seen in women over 60 years of age. (menopause.org.au)
  • These are women with a history of osteoporotic fracture or multiple risk factors for fracture, or those who have failed or are intolerant to other osteoporosis therapies. (drugs.com)
  • Today's approval provides women with postmenopausal osteoporosis who are at high risk of fracture with a new treatment that will reduce this risk," said Hylton V. Joffe, M.D, M.M.Sc. (drugs.com)
  • Postmenopausal high androgen levels were not associated with an elevated risk for CVD. (medpagetoday.com)
  • Over the years, many postmenopausal women have become at risk for mental illnesses such as depression and anxiety. (fitnesshealthzone.com)
  • Asthma was associated with a modestly increased risk for CVD and CHD in postmenopausal women. (ahajournals.org)
  • The risk of ovarian cancer increases in women who have ovulated more over their lifetime. (wikipedia.org)
  • Screening is not recommended in women who are at average risk, as evidence does not support a reduction in death and the high rate of false positive tests may lead to unneeded surgery, which is accompanied by its own risks. (wikipedia.org)
  • These findings strengthen the confidence that population recommendations to engage in regular physical activity are applicable to postmenopausal women. (nih.gov)
  • However, he also cautioned that the findings should be kept in perspective since, for most women, estrogen may provide crucial benefits against heart disease and osteoporosis. (eurekalert.org)
  • Our findings add to the evidence that oestrogen given to postmenopausal women has a mixed effect on the heart, with effect best shown when started early. (wiley.com)
  • The WHT, which commenced in 1986 and involved 303 women randomized into dietary intervention and control groups, yielded results demonstrating a high degree of adherence on the basis of both food-intake questionnaires and clinical laboratory findings. (wikipedia.org)
  • women with a uterus received estrogens plus a synthetic progestin (medroxyprogesterone acetate). (nih.gov)
  • The effect of exercise on circulating estrogens in sedentary postmenopausal women is unknown. (aacrjournals.org)
  • We concluded that a 12-month moderate-intensity exercise intervention in postmenopausal women resulted in significant decreases in serum estrogens. (aacrjournals.org)
  • This seems noteworthy, however, since further activation of the system could be disadvantageous to postmenopausal women who replace estrogen in the context of heart failure, coronary artery disease, or hypertension. (ahajournals.org)
  • To assess effects of long-term HT (at least 1 year's duration) on mortality, cardiovascular outcomes, cancer, gallbladder disease, fracture and cognition in perimenopausal and postmenopausal women during and after cessation of treatment. (nih.gov)
  • we also determined how fracture patterns differed between women 50-64 years of age and those 65 years of age and older. (cmaj.ca)
  • there is no difference in the number of women out of 100 who will have a spine fracture. (cochrane.org)
  • Here we investigated the association of ghrelin with depression and anxiety symptoms in postmenopausal women. (nature.com)
  • To the best of our knowledge, this is the first demonstration of an association between acylated ghrelin and the severity of depression symptoms in postmenopausal women. (nature.com)
  • Main factor causing osteoporosis are age-related decline in level of sex hormones (e.g., postmenopausal women), and secondary osteoporosis that can be due to diseases such as hypogonadism, hyperthyroidism, and gastrointestinal malabsorption syndromes [ 7 ]. (hindawi.com)
  • The women who got synthetic estrogen and progesterone hormones to replace their naturally declining levels were no more (nor less) likely than those who got a placebo to die of stroke or heart failure. (latimes.com)
  • Women who drank 20g of alcohol or more per day (around two and a half units) had higher levels of all hormones. (cancerresearchuk.org)
  • Women who smoked 15 cigarettes a day also had moderately higher levels of all hormones than non-smokers, with the largest difference for testosterone. (cancerresearchuk.org)
  • Two recent studies attempt to better understand the impact of reproductive hormones on clinical presentation and treatment response of depression in women. (womensmentalhealth.org)
  • We found no evidence that higher fat intake isassociated with higher levels of any reproductive hormones in this group ofpostmenopausal women. (cancernetwork.com)
  • The researchers found that as women increased the amount of fatin their diets, the levels of six hormones declined. (cancernetwork.com)
  • Research in monkeys suggests that long-term use of estrogen therapy may reduce levels of androgens - hormones involved in maintaining bone density, muscle mass, sexual function, memory, and psychological wellbeing in postmenopausal women. (news-medical.net)
  • The adrenal glands are the primary source of androgen hormones in women. (news-medical.net)
  • Recently, there has been increased interest in supplementing androgens in older women and research is underway to understand more about these hormones," said Wood. (news-medical.net)
  • HRT had been used for years by women because physicians believed the hormones would help prevent heart disease, osteoporosis, and dementia. (newsinferno.com)
  • We included randomised double-blinded studies of HT versus placebo, taken for at least 1 year by perimenopausal or postmenopausal women. (nih.gov)
  • 1 Nearly 50,000 women 41 to 91 years of age who were perimenopausal or postmenopausal participated in the studies. (aafp.org)
  • Conclusion: Our results confirm that postmenopausal obese women who undergo anterior or posterior colporrhaphy need a follow-up concerning pelvic floor muscle function and suggest that physiotherapy started the earliest possible may aid in preserving postoperative functionality on the long run. (scirp.org)
  • 2009) Effect of Surgically Induced Weight Loss on Pelvic Floor Disorders in Morbidly Obese Women. (scirp.org)
  • A 2-year prospective randomized trial in a tertiary referral center where healthy postmenopausal overweight or obese women were randomized to either PD ( n =35) or NNR diet ( n =35). (nature.com)
  • CONCLUSIONS -Postmenopausal women taking oral estrogen or those taking a combination of estrogen and HRT are more insulin-resistant than women not on HRT, even when women are of comparable total and abdominal adiposity. (diabetesjournals.org)
  • Researchers found no strong evidence that HT has a clinically meaningful impact on the incidence of colorectal cancer.One trial analysed subgroups of 2839 relatively healthy women 50 to 59 years of age who were taking combined continuous HT and 1637 who were taking oestrogen-only HT versus similar-sized placebo groups. (nih.gov)
  • In this randomized trial, we assigned 8556 women who were between the ages of 59 and 80 years and had a bone mineral density T score of -2.5 or less at the femoral neck or spine to receive once-daily lasofoxifene (at a dose of either 0.25 mg or 0.5 mg) or placebo for 5 years. (nih.gov)
  • Endometrial cancer occurred in three women in the placebo group, two women in the lower-dose lasofoxifene group, and two women in the higher-dose lasofoxifene group. (nih.gov)
  • MF101, a botanical extract, is a non-hormonal investigational treatment being tested in a randomized, double-blind, placebo-controlled phase 3a clinical trial to assess the safety and efficacy of MF101 on the frequency of moderate to severe hot flushes in postmenopausal women. (clinicaltrials.gov)
  • Of the 384 randomized patients, the questionnaires were completed by 193 women treated with ginseng and 191 treated with placebo. (healthy.net)
  • Wiklund IK, Mattsson LA, Lindgren R, Limoni C. Effects of a standardized ginseng extract on quality of life and physiological parameters in symptomatic postmenopausal women: a double-blind, placebo-controlled trial. (healthy.net)
  • Daily, the women in the WHI CaD trial took either a supplement containing 1,000 mg of calcium and 400 IU of vitamin D3 or a placebo. (nof.org)
  • The women who took the supplement were more than twice as likely to have vitamin D levels of at least 30 ng/mL (normal according to the Institute of Medicine) as were the women who took the placebo. (nof.org)
  • After one week, women who took creatine, compared with those taking a placebo, showed significant increases in bench-press and leg-press strength (measures of upper- and lower-body strength) and improvement in tests of coordination and balance. (sun-sentinel.com)
  • In the ERA trial, 309 postmenopausal women (mean age 66+/-7 years) with coronary disease were randomized to estrogen, estrogen plus progestin, or placebo, and followed for 3.2 years. (biomedsearch.com)
  • Women receiving at least one year of risedronate for postmenopausal osteoporosis were compared to those receiving placebo or concurrent calcium/vitamin D or both. (cochrane.org)
  • However, the median 3-month PINP change in lumbar spine BMD nonresponders still exceeded the LSC value of 10 microg/L. Although the percentage of teriparatide-treated women with a hip BMD response that met the 3% criterion was significantly greater than for placebo, there was no significant difference between the percentage of teriparatide 20 microg/day and alendronate 10 mg/day responders in the comparison trial. (unboundmedicine.com)
  • After an average followup of 8.7 years, a combination of negative outcomes including coronary heart disease, congestive heart failure, heart attack, ischemic stroke, peripheral arterial disease and cardiovascular death were seen in some 8.5 percent of women who consumed two or more diet drinks a day. (reuters.com)
  • The Women's Health Initiative included 153,840 females over fifty years of age who did not have diabetes at baseline. (medicalnewstoday.com)
  • Most participants were postmenopausal American women with at least some degree of comorbidity, and mean participant age in most studies was over 60 years. (nih.gov)
  • The main limitation in the quality of evidence was that only about 30% of women were 50 to 59 years old at baseline, which is the age at which women are most likely to consider HT for vasomotor symptoms. (nih.gov)
  • Subjects were 40417 postmenopausal Iowa women, aged 55 to 69 years at baseline in 1986. (nih.gov)
  • Women 75-84 years of age have three times as great a chance to have heart failure, compared to women 65-74 years old, according to the release. (upi.com)
  • Among 89,270 women studied over more than 10 years, there were 1,156 cases of acute hospitalized heart failure. (upi.com)
  • Several effective options for colorectal cancer screening are recommended for women 50 to 75 years of age. (aafp.org)
  • Women 50 to 75 years of age should undergo some form of colorectal cancer screening. (aafp.org)
  • Ambulatory, postmenopausal women aged 55-85 years (at least 3 years have elapsed after menopausal) are included at the time of entry into the trial. (clinicaltrials.gov)
  • Women taking oral estrogen ( n = 6) were matched for age (57 ± 3 vs. 58 ± 2 years), weight (87.9 ± 6.0 vs. 83.0 ± 3.9 kg), and BMI (33.9 ± 1.7 vs. 33.9 ± 1.9 kg/m 2 ) with women not on HRT ( n = 6). (diabetesjournals.org)
  • Eight women taking oral estrogen plus progesterone were matched with eight different women not on HRT for age (59 ± 2 vs. 60 ± 2 years), weight (82.8 ± 3.7 vs. 83.7 ± 4.1 kg), and BMI (30.7 ± 1.0 vs. 29.9 ± 1.3 kg/m 2 ). (diabetesjournals.org)
  • By 2030 the prevalence of osteoporosis for women 50 years and older is projected to reach 13.6 million. (clinicaltrials.gov)
  • Sensitivity analyses were carried out on women who took more than 80% of the prescribed treatment for five years. (bmj.com)
  • In 2005-2009, 85 per cent of women in England survived their breast cancer for five years or more. (cancerresearchuk.org)
  • Over the trial's 18 years of follow-up, 7,489 of the women died. (latimes.com)
  • The results are very reassuring, because it suggests that women can use this patch without harm for two years," says Yaffe. (rxpgnews.com)
  • Several years ago, we reviewed a paper suggesting that estrogen may have beneficial effects for women with schizophrenia. (womensmentalhealth.org)
  • WHIMSY enrolled 1,326 women who started WHI treatment when they were between 50 and 55 and continued it for an average of seven years. (nih.gov)
  • The women were approached to participate in a telephone assessment of cognition an average of seven years after that. (nih.gov)
  • To be eligible, physicians had to have a large practice that included women more than 60 years old. (cmaj.ca)
  • The general practitioners were asked to recruit the first five female patients who were more than 60 years of age, regardless of the reason for the consultation. (cmaj.ca)
  • Case report: We report a 55 years old, Para three, woman who presented with postmenopausal bleeding and unilateral adnexal mass and clinically diagnosed. (ebscohost.com)
  • Extended adjuvant endocrine therapy after 5 years of tamoxifen prolongs DFS among women with early-stage breast cancer. (healio.com)
  • It was found, over 6.6 years of follow up, that women who engaged in more than 7 hours per week of moderate-to-vigorous exercise for the last ten years were 16% less likely to develop breast cancer than those who were inactive. (bio-medicine.org)
  • So women have more high blood pressure than men once you get over 60 years of age. (womenshealthmatters.ca)
  • RESEARCH DESIGN AND METHODS -We studied 28 obese, sedentary postmenopausal Caucasian women. (diabetesjournals.org)
  • We have previously shown increased depression and anxiety scores in postmenopausal overweight women, when compared to overweight premenopausal women. (nature.com)
  • Does Surgery Benefit Postmenopausal Overweight Women with Pelvic Floor Dysfunction? (scirp.org)
  • At treatment's end, women who had received hypnotic relaxation therapy reported significantly higher sexual satisfaction and pleasure, as well as less discomfort, the researchers found. (psychcentral.com)
  • Among women with an intact uterus, the risks of stroke , invasive breast cancer , colorectal cancer , endometrial cancer and pulmonary embolism / deep vein thrombosis were not significantly different between vaginal estrogen users and nonusers. (medicalnewstoday.com)
  • The risks of coronary heart disease, stroke, cancer and pulmonary embolism/deep vein thrombosis for women who had undergone hysterectomies were not significantly different in users of vaginal estrogen compared to nonusers. (medicalnewstoday.com)
  • Among the women with benign lesions, postmenopausal women had significantly higher polyunsaturated fatty acids and lower saturated fatty acids in their breasts than premenopausal women. (medindia.net)
  • Those of postmenopausal women receiving HT significantly differed from those of postmenopausal women without HT and were most often dominated by species of Lactobacillus . (frontiersin.org)
  • Noteworthy, HT greatly improved vaginal atrophy scores, decreased vaginal pH, and significantly increased bacterial numbers in comparison to postmenopausal women not receiving HT. (frontiersin.org)
  • In its evidence review, the task force considered results from 18 clinical trials including more than 40,000 women. (upi.com)
  • Previous research by Elkins has shown that clinical hypnosis can reduce hot flashes and associated symptoms among postmenopausal women, including a lessening of anxiety and depression. (psychcentral.com)
  • Effects of ALX1-11 on bone mineral density (BMD) have been documented in a dose-finding Phase II clinical trial in osteoporotic postmenopausal women, supplemented with calcium and Vitamin D3 but without any other treatment for osteoporosis. (clinicaltrials.gov)
  • All of the women had medical coverage with Manitoba Health throughout the observation period, which ended Mar. 31, 2004, and were included in the clinical database of the Manitoba Bone Density Program. (cmaj.ca)
  • For example, the NIH Women's Health Initiative is currently conducting a large, randomized clinical trial to determine the direct benefits and risks of HRT on postmenopausal women," said Dr. Lenfant. (eurekalert.org)
  • In a recent randomized, single-blind, controlled, clinical trial, 187 postmenopausal women reporting at least 7 hot flashes per day received five weekly sessions of either clinical hypnosis or structured-attention control. (womensmentalhealth.org)
  • A large clinical trial suggests that soy may not have any positive effects on cognition in postmenopausal women. (womensmentalhealth.org)
  • Data from three clinical trials involving postmenopausal women with osteoporosis were examined. (unboundmedicine.com)
  • The safety and efficacy of Evenity were demonstrated in two clinical trials involving a total of more than 11,000 women with postmenopausal osteoporosis. (drugs.com)
  • The Women's Health Initiative (WHI) was a series of clinical studies initiated by the U.S. National Institutes of Health (NIH) in 1991, to address major health issues causing morbidity and mortality in postmenopausal women. (wikipedia.org)
  • As a consequence, beginning in 1991, NIH strengthened the policy to require, rather than recommend, the inclusion of women in clinical research (when appropriate) in order to obtain funding. (wikipedia.org)
  • These women were matched with a control group of 972 participants who had not had strokes. (innovations-report.com)
  • Furthermore, declining levels of estrogen and progesterone could leave women more vulnerable to vaginal infections, thus creating a fertile environment for STDS. (healthcentral.com)
  • Some women take a vaginal form of estrogen, and it has not been known whether that treatment carries risks similar to the tablet form. (medicalnewstoday.com)
  • The vaginal microbiomes of these women were characterized by 16S rRNA gene sequencing and bacterial abundances were quantified by qPCR. (frontiersin.org)
  • Compare in postmenopausal women with established osteoporosis the effect of treatment with teriparatide 20 micrograms/day subcutaneous with the effect of salmon calcitonin 100 IU/day subcutaneous on change in lumbar spine BMD. (clinicaltrials.gov)
  • To compare in postmenopausal women with established osteoporosis the effect of treatment with teriparatide 20 micrograms/day subcutaneous with the effect of salmon calcitonin 100 IU/day subcutaneous on change in lumbar spine BMD. (clinicaltrials.gov)
  • A prospective trial was done to examine if teriparatide administration following instrumented lumbar posterolateral fusion would improve bone union in postmenopausal women with osteoporosis.Teriparatide was compared to the use of bisphosphonate after surgery. (spineuniverse.com)
  • Our data suggest that fat mass is the significant determinant of BMD at the lumbar spine and proximal femur, and lean mass does not have an impact on BMD when fat mass was taken into account in Turkish postmenopausal women. (unboundmedicine.com)
  • Only treatment-compliant women who had lumbar spine BMD measurements at all specified time points in these trials were included. (unboundmedicine.com)
  • For reference, we also examined the percentage of women with lumbar spine BMD responses to alendronate. (unboundmedicine.com)
  • The median 3-month change in amino-terminal extension peptide of procollagen type 1 [PINP] in women who had a lumbar spine BMD response to teriparatide at 18 months was larger than in women who did not have a lumbar spine BMD response. (unboundmedicine.com)
  • This analysis demonstrates that the vast majority of treatment-compliant postmenopausal women with osteoporosis and minimal prior bisphosphonate exposure have a lumbar spine BMD response to teriparatide that meets or exceeds the LSC. (unboundmedicine.com)
  • This was regardless of a woman's age or how much time had passed since she had become postmenopausal. (medicaldaily.com)
  • The researchers examined the association between dietary magnesium intake and fatal CHD and SCD in a cohort of 153,569 postmenopausal women who participated in the Women's Health Initiative between 1993 and 1998. (healio.com)
  • Women who experienced anxiety were five times more likely than their peers to experience joint pain, muscle pain, severe urogenital symptoms, and hot flashes. (goodtherapy.org)
  • Researchers noted that postmenopausal sexual health can be affected by factors other than hot flashes, including fatigue, self-esteem, a partner's health, relationship quality, and a lack of interest by either or both partners. (psychcentral.com)
  • Researchers in the latest issue of Harvard Women's Health Watch had explored the physiology of hot flashes experienced by some women in their menopausal or postmenopausal age. (medindia.net)
  • One line of research shows that women who have hot flashes have a lower tolerance for changes in the body's core (innermost) temperature than women who don't have hot flashes. (medindia.net)
  • Women who have hot flashes have a thermoneutral zone that's so narrow, even the tiniest changes in core body temperature can trigger sweating (or chills). (medindia.net)
  • Hot flashes affect approximately 75% of postmenopausal women. (bioportfolio.com)
  • Rationale: Venlafaxine may help relieve hot flashes in women who have had breast cancer. (bioportfolio.com)
  • Hypnosis or focused attention may help control hot flashes in postmenopausal women. (bioportfolio.com)
  • Hot flashes are experienced by most midlife women. (bioportfolio.com)
  • Compared to women who never or seldom consume diet drinks, those who drank two or more a day were 30 percent more likely to suffer a cardiovascular event and 50 percent more likely to die from related disease, researchers found. (reuters.com)
  • With exercise recommended for them, older women may be more interested in simply walking instead of other more extreme exercise, including working out at a gym, researchers say. (upi.com)
  • Researchers found that HIV-positive postmenopausal women had lower bone mineral density at both the spine and hip than HIV-negative postmenopausal women. (eurekalert.org)
  • For women with an intact uterus, progestin was widely added to HRT regimens in the 1980s and '90s after researchers found that estrogen-alone regimens increased rates of endometrial cancers in such women. (latimes.com)
  • Older women should take greater care of their teeth, say researchers. (hindustantimes.com)
  • There is no evidence that a high-fat diet predisposes older women to breast cancer, report researchers from Harvard Medical School. (cancernetwork.com)
  • With an estimated 182,460 new cases diagnosed in the United States in 2008, breast cancer is recognized as the most common cancer affecting U.S. women" says Dr. Tricia M Peters from the U.S. National Cancer Institute, Bethesda, Maryland, who headed up an international team of researchers. (bio-medicine.org)
  • Pulse pressure and coronary atherosclerosis progression in postmenopausal women. (biomedsearch.com)
  • In postmenopausal women with coronary disease, increased levels of baseline pulse pressure are associated with subsequent progression of coronary atherosclerosis in postmenopausal women. (biomedsearch.com)
  • To assess the association of high serum androgen levels, as a postmenopausal remnant of PCOS, with the prevalence of atherosclerosis and incidence of CVD in postmenopausal women. (medpagetoday.com)
  • It is debatable how easy it is for some older women to achieve this level of activity and we should not forget that there are still positive health benefits to consistent moderate activity such as walking, swimming, golf or gentle cycling. (netdoctor.co.uk)
  • Older women also often have difficulty getting a correct diagnosis of STD. (healthcentral.com)
  • Taking the calcium and vitamin D supplements was especially helpful in raising vitamin D levels in women who were older, women who had a low intake, and women who had levels first measured in the winter-what you might expect. (nof.org)
  • Ischemic stroke accounts for 87% of all stroke.5 In women older than 60, stroke is the second leading cause of death. (todaysdietitian.com)
  • However, there is now evidence that vitamin D deficiency is also associated with other medical conditions important in older women. (redorbit.com)
  • Q . Could you discuss the benefits of creatine supplements for older, postmenopausal women? (sun-sentinel.com)
  • But most of these studies have found that creatine doesn't enhance performance in older men and women, and doesn't improve endurance at any age. (sun-sentinel.com)
  • They concluded that impact and resistance training can improve bone health, an important issue in postmenopause, but walking likely does not improve bone health, though many older women prefer it to other activities. (medicaldaily.com)
  • In addition, other studies have suggested that older, postmenopausal women may respond more poorly to antidepressants than premenopausal women. (womensmentalhealth.org)
  • Regulation of androgen levels may be particularly important in postmenopausal women because observational studies have shown that older women who have higher levels tend to be healthier. (news-medical.net)
  • The recommendations from the task force are generally directed at older women who may be wondering if their HRT is working to prevent the diseases or complications it was prescribed to defend. (newsinferno.com)
  • And when you get into the older age group, women not only catch up, they overtake men,' Dr. Harvey said. (womenshealthmatters.ca)
  • The effects of tibolone in older postmenopausal women. (menopause.org.au)
  • RESEARCH DESIGN AND METHODS Case subjects ( n = 212) were all postmenopausal women with treated diabetes who sustained an incident fatal or nonfatal MI between July 1986 and December 1994. (diabetesjournals.org)
  • Methods and Results Estrogen status and components of the renin-angiotensin system were examined in a population-based sample of postmenopausal women and age-matched men. (ahajournals.org)
  • These changes were associated with a significant reduction in PPARγ2 expression in the bone marrow of risedronate-treated women. (springer.com)
  • Postmenopausal women are more prone to osteoporosis due to reduction in estrogen which may further lead to elevation of oxidative stress and lipid accumulation which will promote osteoblasts apoptosis. (hindawi.com)
  • 11 This hypothesis would explain the very modest blood pressure (BP) elevation noted with premenopausal contraceptive estrogen administration 2 and its absence and even BP reduction noted in some postmenopausal women receiving ERT. (ahajournals.org)
  • Do we need to exercise more frequently than younger women to gain the same heart health benefits? (empowher.com)
  • These symptoms are generally absent in women with a wider thermoneutral zone, explains the Harvard Women's Health Watch. (medindia.net)
  • Postmenopausal women have a number of unique health-promotion and disease-prevention needs. (aafp.org)
  • However, many effective preventive health strategies for postmenopausal women are underutilized. (aafp.org)
  • EMAS has risen to the challenge of increasing awareness of vitamin D deficiency to women and health professionals. (redorbit.com)
  • Postmenopausal women often seek non-pharmacologic interventions for the protection of bone health. (clinicaltrials.gov)
  • While high levels of "good" cholesterol are associated with heart health benefits, they may not always be as protective in the case of postmenopausal women. (medicaldaily.com)
  • The higher concentration of total HDL particles as well as a high number of small HDL particles were found to be beneficial for the heart health of the postmenopausal women. (medicaldaily.com)
  • HRT has been prescribed to menopausal women as a preventative measure in the treatment of possible future health problems like heart disease but the recommendations from the task force are against that. (newsinferno.com)
  • Cardiovascular health in women with PCOS might be better than was anticipated. (medpagetoday.com)
  • This type of exercise is excellent for not only improving the health of postmenopausal women, but it also is known to make you feel better mentally. (fitnesshealthzone.com)
  • The women in the hypnotic relaxation therapy group received a hypnotic induction followed by suggestions for relaxation, coolness and mental imagery. (psychcentral.com)
  • None of the women were using hormonereplacement therapy. (cancernetwork.com)
  • OBJECTIVES: I. Determine the time to progression of postmenopausal women with metastatic breast cancer treated with letrozole (Femara) as first-line therapy. (knowcancer.com)
  • rather, unchanged or slightly lower blood pressure levels were observed in women receiving such therapy. (ahajournals.org)
  • Thus, determination of AR status may provide additional information on prognosis for postmenopausal women with breast cancer, and provide novel opportunities for targeted therapy. (aacrjournals.org)
  • Determination of AR status may provide additional information on prognosis for postmenopausal women with breast cancer, and provide women with ER- or triple-negative tumors novel opportunities for targeted therapy. (aacrjournals.org)
  • Amenorrhea is achieved by about 80% of women after the first month of treatment with tibolone and over 90% after the third month of therapy [4]. (menopause.org.au)
  • As the incidence of these diseases increases according to age, women over the age of 50 bear much of the disease burden. (wikipedia.org)