An imaging technique using compounds labelled with short-lived positron-emitting radionuclides (such as carbon-11, nitrogen-13, oxygen-15 and fluorine-18) to measure cell metabolism. It has been useful in study of soft tissues such as CANCER; CARDIOVASCULAR SYSTEM; and brain. SINGLE-PHOTON EMISSION-COMPUTED TOMOGRAPHY is closely related to positron emission tomography, but uses isotopes with longer half-lives and resolution is lower.
Tomography using radioactive emissions from injected RADIONUCLIDES and computer ALGORITHMS to reconstruct an image.
The compound is given by intravenous injection to do POSITRON-EMISSION TOMOGRAPHY for the assessment of cerebral and myocardial glucose metabolism in various physiological or pathological states including stroke and myocardial ischemia. It is also employed for the detection of malignant tumors including those of the brain, liver, and thyroid gland. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1162)
Compounds that are used in medicine as sources of radiation for radiotherapy and for diagnostic purposes. They have numerous uses in research and industry. (Martindale, The Extra Pharmacopoeia, 30th ed, p1161)
Tomography using x-ray transmission and a computer algorithm to reconstruct the image.
Unstable isotopes of fluorine that decay or disintegrate emitting radiation. F atoms with atomic weights 17, 18, and 20-22 are radioactive fluorine isotopes.
The use of combination of imaging techniques or platforms (e.g., MRI SCAN and PET SCAN) encompassing aspects of anatomical, functional, or molecular imaging methods.
Unstable isotopes of carbon that decay or disintegrate emitting radiation. C atoms with atomic weights 10, 11, and 14-16 are radioactive carbon isotopes.
Unstable isotopes of oxygen that decay or disintegrate emitting radiation. O atoms with atomic weights 13, 14, 15, 19, and 20 are radioactive oxygen isotopes.
The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM.
A substituted benzamide that has antipsychotic properties. It is a dopamine D2 receptor (see RECEPTORS, DOPAMINE D2) antagonist.
Non-invasive method of demonstrating internal anatomy based on the principle that atomic nuclei in a strong magnetic field absorb pulses of radiofrequency energy and emit them as radiowaves which can be reconstructed into computerized images. The concept includes proton spin tomographic techniques.
Unstable isotopes of copper that decay or disintegrate emitting radiation. Cu atoms with atomic weights 58-62, 64, and 66-68 are radioactive copper isotopes.
Unstable isotopes of nitrogen that decay or disintegrate emitting radiation. N atoms with atomic weights 12, 13, 16, 17, and 18 are radioactive nitrogen isotopes.
The circulation of blood through the BLOOD VESSELS of the BRAIN.
A method of computed tomography that uses radionuclides which emit a single photon of a given energy. The camera is rotated 180 or 360 degrees around the patient to capture images at multiple positions along the arc. The computer is then used to reconstruct the transaxial, sagittal, and coronal images from the 3-dimensional distribution of radionuclides in the organ. The advantages of SPECT are that it can be used to observe biochemical and physiological processes as well as size and volume of the organ. The disadvantage is that, unlike positron-emission tomography where the positron-electron annihilation results in the emission of 2 photons at 180 degrees from each other, SPECT requires physical collimation to line up the photons, which results in the loss of many available photons and hence degrades the image.
Radioactive substances added in minute amounts to the reacting elements or compounds in a chemical process and traced through the process by appropriate detection methods, e.g., Geiger counter. Compounds containing tracers are often said to be tagged or labeled. (Hawley's Condensed Chemical Dictionary, 12th ed)
2-Deoxy-D-arabino-hexose. An antimetabolite of glucose with antiviral activity.
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
A technique of inputting two-dimensional images into a computer and then enhancing or analyzing the imagery into a form that is more useful to the human observer.
Any visual display of structural or functional patterns of organs or tissues for diagnostic evaluation. It includes measuring physiologic and metabolic responses to physical and chemical stimuli, as well as ultramicroscopy.
Imaging methods that result in sharp images of objects located on a chosen plane and blurred images located above or below the plane.
The creation of a visual display of the inside of the entire body of a human or animal for the purposes of diagnostic evaluation. This is most commonly achieved by using MAGNETIC RESONANCE IMAGING; or POSITRON EMISSION TOMOGRAPHY.
Accumulation of a drug or chemical substance in various organs (including those not relevant to its pharmacologic or therapeutic action). This distribution depends on the blood flow or perfusion rate of the organ, the ability of the drug to penetrate organ membranes, tissue specificity, protein binding. The distribution is usually expressed as tissue to plasma ratios.
A beta-hydroxylated derivative of phenylalanine. The D-form of dihydroxyphenylalanine has less physiologic activity than the L-form and is commonly used experimentally to determine whether the pharmacological effects of LEVODOPA are stereospecific.
Unstable isotopes of gallium that decay or disintegrate emitting radiation. Ga atoms with atomic weights 63-68, 70 and 72-76 are radioactive gallium isotopes.
In screening and diagnostic tests, the probability that a person with a positive test is a true positive (i.e., has the disease), is referred to as the predictive value of a positive test; whereas, the predictive value of a negative test is the probability that the person with a negative test does not have the disease. Predictive value is related to the sensitivity and specificity of the test.
Isotopes that exhibit radioactivity and undergo radioactive decay. (From Grant & Hackh's Chemical Dictionary, 5th ed & McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
A subfamily of G-PROTEIN-COUPLED RECEPTORS that bind the neurotransmitter DOPAMINE and modulate its effects. D2-class receptor genes contain INTRONS, and the receptors inhibit ADENYLYL CYCLASES.
Unstable isotopes of rubidium that decay or disintegrate emitting radiation. Rb atoms with atomic weights 79-84, and 86-95 are radioactive rubidium isotopes.
The statistical reproducibility of measurements (often in a clinical context), including the testing of instrumentation or techniques to obtain reproducible results. The concept includes reproducibility of physiological measurements, which may be used to develop rules to assess probability or prognosis, or response to a stimulus; reproducibility of occurrence of a condition; and reproducibility of experimental results.
Imaging techniques used to colocalize sites of brain functions or physiological activity with brain structures.
A nitroimidazole that sensitizes normally radio-resistant hypoxic cells to radiation. It may also be directly cytotoxic to hypoxic cells and has been proposed as an antineoplastic.
Methods which attempt to express in replicable terms the extent of the neoplasm in the patient.
The circulation of blood through the CORONARY VESSELS of the HEART.
A primary source of energy for living organisms. It is naturally occurring and is found in fruits and other parts of plants in its free state. It is used therapeutically in fluid and nutrient replacement.
Amides of salicylic acid.
A potent benzodiazepine receptor antagonist. Since it reverses the sedative and other actions of benzodiazepines, it has been suggested as an antidote to benzodiazepine overdoses.
An imaging method using LASERS that is used for mapping subsurface structure. When a reflective site in the sample is at the same optical path length (coherence) as the reference mirror, the detector observes interference fringes.
A genus of the subfamily CERCOPITHECINAE, family CERCOPITHECIDAE, consisting of five named species: PAPIO URSINUS (chacma baboon), PAPIO CYNOCEPHALUS (yellow baboon), PAPIO PAPIO (western baboon), PAPIO ANUBIS (or olive baboon), and PAPIO HAMADRYAS (hamadryas baboon). Members of the Papio genus inhabit open woodland, savannahs, grassland, and rocky hill country. Some authors consider MANDRILLUS a subgenus of Papio.
Tumors or cancer of the LUNG.
The study of the chemical and physical phenomena of radioactive substances.
Computed tomography where there is continuous X-ray exposure to the patient while being transported in a spiral or helical pattern through the beam of irradiation. This provides improved three-dimensional contrast and spatial resolution compared to conventional computed tomography, where data is obtained and computed from individual sequential exposures.
A drug formerly used as an antipsychotic and treatment of various movement disorders. Tetrabenazine blocks neurotransmitter uptake into adrenergic storage vesicles and has been used as a high affinity label for the vesicle transport system.
The use of molecularly targeted imaging probes to localize and/or monitor biochemical and cellular processes via various imaging modalities that include RADIONUCLIDE IMAGING; ULTRASONOGRAPHY; MAGNETIC RESONANCE IMAGING; FLUORESCENCE IMAGING; and MICROSCOPY.
A species of baboon in the family CERCOPITHECIDAE with a somewhat different social structure than PAPIO HAMADRYAS. They inhabit several areas in Africa south of the Sahara.
Striped GRAY MATTER and WHITE MATTER consisting of the NEOSTRIATUM and paleostriatum (GLOBUS PALLIDUS). It is located in front of and lateral to the THALAMUS in each cerebral hemisphere. The gray substance is made up of the CAUDATE NUCLEUS and the lentiform nucleus (the latter consisting of the GLOBUS PALLIDUS and PUTAMEN). The WHITE MATTER is the INTERNAL CAPSULE.
Techniques for labeling a substance with a stable or radioactive isotope. It is not used for articles involving labeled substances unless the methods of labeling are substantively discussed. Tracers that may be labeled include chemical substances, cells, or microorganisms.
Nucleosides that have two hydroxy groups removed from the sugar moiety. The majority of these compounds have broad-spectrum antiretroviral activity due to their action as antimetabolites. The nucleosides are phosphorylated intracellularly to their 5'-triphosphates and act as chain-terminating inhibitors of viral reverse transcription.
A subtype of dopamine D2 receptors that are highly expressed in the LIMBIC SYSTEM of the brain.
Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
Transfer of a neoplasm from its primary site to lymph nodes or to distant parts of the body by way of the lymphatic system.
Drugs that bind to but do not activate DOPAMINE RECEPTORS, thereby blocking the actions of dopamine or exogenous agonists. Many drugs used in the treatment of psychotic disorders (ANTIPSYCHOTIC AGENTS) are dopamine antagonists, although their therapeutic effects may be due to long-term adjustments of the brain rather than to the acute effects of blocking dopamine receptors. Dopamine antagonists have been used for several other clinical purposes including as ANTIEMETICS, in the treatment of Tourette syndrome, and for hiccup. Dopamine receptor blockade is associated with NEUROLEPTIC MALIGNANT SYNDROME.
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
A class of organic compounds containing a ring structure made up of more than one kind of atom, usually carbon plus another atom. The ring structure can be aromatic or nonaromatic.
The flow of BLOOD through or around an organ or region of the body.
Devices or objects in various imaging techniques used to visualize or enhance visualization by simulating conditions encountered in the procedure. Phantoms are used very often in procedures employing or measuring x-irradiation or radioactive material to evaluate performance. Phantoms often have properties similar to human tissue. Water demonstrates absorbing properties similar to normal tissue, hence water-filled phantoms are used to map radiation levels. Phantoms are used also as teaching aids to simulate real conditions with x-ray or ultrasonic machines. (From Iturralde, Dictionary and Handbook of Nuclear Medicine and Clinical Imaging, 1990)
Elements of limited time intervals, contributing to particular results or situations.
A single lung lesion that is characterized by a small round mass of tissue, usually less than 1 cm in diameter, and can be detected by chest radiography. A solitary pulmonary nodule can be associated with neoplasm, tuberculosis, cyst, or other anomalies in the lung, the CHEST WALL, or the PLEURA.
The hollow, muscular organ that maintains the circulation of the blood.
A phosphodiesterase inhibitor that blocks uptake and metabolism of adenosine by erythrocytes and vascular endothelial cells. Dipyridamole also potentiates the antiaggregating action of prostacyclin. (From AMA Drug Evaluations Annual, 1994, p752)
The thin layer of GRAY MATTER on the surface of the CEREBRAL HEMISPHERES that develops from the TELENCEPHALON and folds into gyri and sulchi. It reaches its highest development in humans and is responsible for intellectual faculties and higher mental functions.
Projection of near-IR light (INFRARED RAYS), in the 700-1000 nm region, across an object in parallel beams to an array of sensitive photodetectors. This is repeated at various angles and a mathematical reconstruction provides three dimensional MEDICAL IMAGING of tissues. Based on the relative transparency of tissues to this spectra, it has been used to monitor local oxygenation, brain and joints.
One of the catecholamine NEUROTRANSMITTERS in the brain. It is derived from TYROSINE and is the precursor to NOREPINEPHRINE and EPINEPHRINE. Dopamine is a major transmitter in the extrapyramidal system of the brain, and important in regulating movement. A family of receptors (RECEPTORS, DOPAMINE) mediate its action.
A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57)
A narcotic antagonist similar in action to NALOXONE. It is used to remobilize animals after ETORPHINE neuroleptanalgesia and is considered a specific antagonist to etorphine.
A spiro butyrophenone analog similar to HALOPERIDOL and other related compounds. It has been recommended in the treatment of SCHIZOPHRENIA.
The largest and most lateral of the BASAL GANGLIA lying between the lateral medullary lamina of the GLOBUS PALLIDUS and the EXTERNAL CAPSULE. It is part of the neostriatum and forms part of the LENTIFORM NUCLEUS along with the GLOBUS PALLIDUS.
A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.
The creation and display of functional images showing where the blood is flowing into the MYOCARDIUM by following over time the distribution of tracers injected into the blood stream.
Unanticipated information discovered in the course of testing or medical care. Used in discussions of information that may have social or psychological consequences, such as when it is learned that a child's biological father is someone other than the putative father, or that a person tested for one disease or disorder has, or is at risk for, something else.
Elongated gray mass of the neostriatum located adjacent to the lateral ventricle of the brain.
The part of the cerebral hemisphere anterior to the central sulcus, and anterior and superior to the lateral sulcus.
Types of spiral computed tomography technology in which multiple slices of data are acquired simultaneously improving the resolution over single slice acquisition technology.
The range or frequency distribution of a measurement in a population (of organisms, organs or things) that has not been selected for the presence of disease or abnormality.
A pyrimidine nucleoside formed in the body by the deamination of CYTARABINE.
Volume of circulating BLOOD. It is the sum of the PLASMA VOLUME and ERYTHROCYTE VOLUME.
A nonmetallic, diatomic gas that is a trace element and member of the halogen family. It is used in dentistry as flouride (FLUORIDES) to prevent dental caries.
A specialty field of radiology concerned with diagnostic, therapeutic, and investigative use of radioactive compounds in a pharmaceutical form.
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.
The process of generating three-dimensional images by electronic, photographic, or other methods. For example, three-dimensional images can be generated by assembling multiple tomographic images with the aid of a computer, while photographic 3-D images (HOLOGRAPHY) can be made by exposing film to the interference pattern created when two laser light sources shine on an object.
A malignant disease characterized by progressive enlargement of the lymph nodes, spleen, and general lymphoid tissue. In the classical variant, giant usually multinucleate Hodgkin's and REED-STERNBERG CELLS are present; in the nodular lymphocyte predominant variant, lymphocytic and histiocytic cells are seen.
Quantitative determination of receptor (binding) proteins in body fluids or tissue using radioactively labeled binding reagents (e.g., antibodies, intracellular receptors, plasma binders).
Methods developed to aid in the interpretation of ultrasound, radiographic images, etc., for diagnosis of disease.
Compounds with a benzene ring fused to a thiazole ring.
The making of a radiograph of an object or tissue by recording on a photographic plate the radiation emitted by radioactive material within the object. (Dorland, 27th ed)
Substances used to allow enhanced visualization of tissues.
Unstable isotopes of iodine that decay or disintegrate emitting radiation. I atoms with atomic weights 117-139, except I 127, are radioactive iodine isotopes.
A procedure consisting of a sequence of algebraic formulas and/or logical steps to calculate or determine a given task.
The rate at which oxygen is used by a tissue; microliters of oxygen STPD used per milligram of tissue per hour; the rate at which oxygen enters the blood from alveolar gas, equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body. (Stedman, 25th ed, p346)
The span of viability of a tissue or an organ.
Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.
A colorless alkaline gas. It is formed in the body during decomposition of organic materials during a large number of metabolically important reactions. Note that the aqueous form of ammonia is referred to as AMMONIUM HYDROXIDE.
Posterior portion of the CEREBRAL HEMISPHERES responsible for processing visual sensory information. It is located posterior to the parieto-occipital sulcus and extends to the preoccipital notch.
A class of compounds of the type R-M, where a C atom is joined directly to any other element except H, C, N, O, F, Cl, Br, I, or At. (Grant & Hackh's Chemical Dictionary, 5th ed)
The muscle tissue of the HEART. It is composed of striated, involuntary muscle cells (MYOCYTES, CARDIAC) connected to form the contractile pump to generate blood flow.
Combination or superimposition of two images for demonstrating differences between them (e.g., radiograph with contrast vs. one without, radionuclide images using different radionuclides, radiograph vs. radionuclide image) and in the preparation of audiovisual materials (e.g., offsetting identical images, coloring of vessels in angiograms).
The local recurrence of a neoplasm following treatment. It arises from microscopic cells of the original neoplasm that have escaped therapeutic intervention and later become clinically visible at the original site.
Improvement of the quality of a picture by various techniques, including computer processing, digital filtering, echocardiographic techniques, light and ultrastructural MICROSCOPY, fluorescence spectrometry and microscopy, scintigraphy, and in vitro image processing at the molecular level.
A serotonin receptor subtype found distributed through the CENTRAL NERVOUS SYSTEM where they are involved in neuroendocrine regulation of ACTH secretion. The fact that this serotonin receptor subtype is particularly sensitive to SEROTONIN RECEPTOR AGONISTS such as BUSPIRONE suggests its role in the modulation of ANXIETY and DEPRESSION.
Large subcortical nuclear masses derived from the telencephalon and located in the basal regions of the cerebral hemispheres.
The part of brain that lies behind the BRAIN STEM in the posterior base of skull (CRANIAL FOSSA, POSTERIOR). It is also known as the "little brain" with convolutions similar to those of CEREBRAL CORTEX, inner white matter, and deep cerebellar nuclei. Its function is to coordinate voluntary movements, maintain balance, and learn motor skills.
Neoplasms of the intracranial components of the central nervous system, including the cerebral hemispheres, basal ganglia, hypothalamus, thalamus, brain stem, and cerebellum. Brain neoplasms are subdivided into primary (originating from brain tissue) and secondary (i.e., metastatic) forms. Primary neoplasms are subdivided into benign and malignant forms. In general, brain tumors may also be classified by age of onset, histologic type, or presenting location in the brain.
Cell-surface proteins that bind dopamine with high affinity and trigger intracellular changes influencing the behavior of cells.
Non-invasive methods of visualizing the CENTRAL NERVOUS SYSTEM, especially the brain, by various imaging modalities.
Computed tomography modalities which use a cone or pyramid-shaped beam of radiation.
A tomographic technique for obtaining 3-dimensional images with transmission electron microscopy.
Any visible result of a procedure which is caused by the procedure itself and not by the entity being analyzed. Common examples include histological structures introduced by tissue processing, radiographic images of structures that are not naturally present in living tissue, and products of chemical reactions that occur during analysis.
Paired bodies containing mostly GRAY MATTER and forming part of the lateral wall of the THIRD VENTRICLE of the brain.
Dominance of one cerebral hemisphere over the other in cerebral functions.
The application of scientific knowledge or technology to the field of radiology. The applications center mostly around x-ray or radioisotopes for diagnostic and therapeutic purposes but the technological applications of any radiation or radiologic procedure is within the scope of radiologic technology.
A phenethylamine found in EPHEDRA SINICA. PSEUDOEPHEDRINE is an isomer. It is an alpha- and beta-adrenergic agonist that may also enhance release of norepinephrine. It has been used for asthma, heart failure, rhinitis, and urinary incontinence, and for its central nervous system stimulatory effects in the treatment of narcolepsy and depression. It has become less extensively used with the advent of more selective agonists.
Self-generated faint acoustic signals from the inner ear (COCHLEA) without external stimulation. These faint signals can be recorded in the EAR CANAL and are indications of active OUTER AUDITORY HAIR CELLS. Spontaneous otoacoustic emissions are found in all classes of land vertebrates.
Studies to determine the advantages or disadvantages, practicability, or capability of accomplishing a projected plan, study, or project.
A heterogeneous aggregate of at least three distinct histological types of lung cancer, including SQUAMOUS CELL CARCINOMA; ADENOCARCINOMA; and LARGE CELL CARCINOMA. They are dealt with collectively because of their shared treatment strategy.
Positive test results in subjects who do not possess the attribute for which the test is conducted. The labeling of healthy persons as diseased when screening in the detection of disease. (Last, A Dictionary of Epidemiology, 2d ed)
X-ray image-detecting devices that make a focused image of body structures lying in a predetermined plane from which more complex images are computed.
Tumors or cancer of the MEDIASTINUM.
Specialized non-fenestrated tightly-joined ENDOTHELIAL CELLS with TIGHT JUNCTIONS that form a transport barrier for certain substances between the cerebral capillaries and the BRAIN tissue.
One of the convolutions on the medial surface of the CEREBRAL HEMISPHERES. It surrounds the rostral part of the brain and CORPUS CALLOSUM and forms part of the LIMBIC SYSTEM.
Treatment of chronic, severe and intractable psychiatric disorders by surgical removal or interruption of certain areas or pathways in the brain, especially in the prefrontal lobes.
A value equal to the total volume flow divided by the cross-sectional area of the vascular bed.
Lower lateral part of the cerebral hemisphere responsible for auditory, olfactory, and semantic processing. It is located inferior to the lateral fissure and anterior to the OCCIPITAL LOBE.
A statistical technique that isolates and assesses the contributions of categorical independent variables to variation in the mean of a continuous dependent variable.
A group of compounds with the heterocyclic ring structure of benzo(c)pyridine. The ring structure is characteristic of the group of opium alkaloids such as papaverine. (From Stedman, 25th ed)
Sodium chloride-dependent neurotransmitter symporters located primarily on the PLASMA MEMBRANE of serotonergic neurons. They are different than SEROTONIN RECEPTORS, which signal cellular responses to SEROTONIN. They remove SEROTONIN from the EXTRACELLULAR SPACE by high affinity reuptake into PRESYNAPTIC TERMINALS. Regulates signal amplitude and duration at serotonergic synapses and is the site of action of the SEROTONIN UPTAKE INHIBITORS.
A membrane in the midline of the THORAX of mammals. It separates the lungs between the STERNUM in front and the VERTEBRAL COLUMN behind. It also surrounds the HEART, TRACHEA, ESOPHAGUS, THYMUS, and LYMPH NODES.
The production of an image obtained by cameras that detect the radioactive emissions of an injected radionuclide as it has distributed differentially throughout tissues in the body. The image obtained from a moving detector is called a scan, while the image obtained from a stationary camera device is called a scintiphotograph.
They are oval or bean shaped bodies (1 - 30 mm in diameter) located along the lymphatic system.
A sulfur-containing essential L-amino acid that is important in many body functions.
Care given during the period prior to undergoing surgery when psychological and physical preparations are made according to the special needs of the individual patient. This period spans the time between admission to the hospital to the time the surgery begins. (From Dictionary of Health Services Management, 2d ed)
Tests designed to assess neurological function associated with certain behaviors. They are used in diagnosing brain dysfunction or damage and central nervous system disorders or injury.
Behavioral manifestations of cerebral dominance in which there is preferential use and superior functioning of either the left or the right side, as in the preferred use of the right hand or right foot.
The total amount (cell number, weight, size or volume) of tumor cells or tissue in the body.
INFLAMMATION of any ARTERIES.
Sodium chloride-dependent neurotransmitter symporters located primarily on the PLASMA MEMBRANE of dopaminergic neurons. They remove DOPAMINE from the EXTRACELLULAR SPACE by high affinity reuptake into PRESYNAPTIC TERMINALS and are the target of DOPAMINE UPTAKE INHIBITORS.
Removal and pathologic examination of specimens in the form of small pieces of tissue from the living body.
A graphic means for assessing the ability of a screening test to discriminate between healthy and diseased persons; may also be used in other studies, e.g., distinguishing stimuli responses as to a faint stimuli or nonstimuli.
An element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on earth and essential for respiration.
A catecholamine derivative with specificity for BETA-1 ADRENERGIC RECEPTORS. It is commonly used as a cardiotonic agent after CARDIAC SURGERY and during DOBUTAMINE STRESS ECHOCARDIOGRAPHY.
A species of the genus MACACA inhabiting India, China, and other parts of Asia. The species is used extensively in biomedical research and adapts very well to living with humans.
A dibenzoxepin tricyclic compound. It displays a range of pharmacological actions including maintaining adrenergic innervation. Its mechanism of action is not fully understood, but it appears to block reuptake of monoaminergic neurotransmitters into presynaptic terminals. It also possesses anticholinergic activity and modulates antagonism of histamine H(1)- and H(2)-receptors.
Changes in the amounts of various chemicals (neurotransmitters, receptors, enzymes, and other metabolites) specific to the area of the central nervous system contained within the head. These are monitored over time, during sensory stimulation, or under different disease states.
Compounds that contain the radical R2C=N.OH derived from condensation of ALDEHYDES or KETONES with HYDROXYLAMINE. Members of this group are CHOLINESTERASE REACTIVATORS.
Isomeric forms and derivatives of butanol (C4H9OH).
An enzyme that catalyzes the conversion of ATP and thymidine to ADP and thymidine 5'-phosphate. Deoxyuridine can also act as an acceptor and dGTP as a donor. (From Enzyme Nomenclature, 1992) EC 2.7.1.21.
A clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
Tomography using x-ray transmission.
Endoscopic examination, therapy or surgery of the anterior superior mediastinum of the thorax.
Prolonged dysfunction of the myocardium after a brief episode of severe ischemia, with gradual return of contractile activity.
Methods for visualizing REGIONAL BLOOD FLOW, metabolic, electrical, or other physiological activities in the CENTRAL NERVOUS SYSTEM using various imaging modalities.
The formation of an area of NECROSIS in the CEREBRUM caused by an insufficiency of arterial or venous blood flow. Infarcts of the cerebrum are generally classified by hemisphere (i.e., left vs. right), lobe (e.g., frontal lobe infarction), arterial distribution (e.g., INFARCTION, ANTERIOR CEREBRAL ARTERY), and etiology (e.g., embolic infarction).
A guanidine analog with specific affinity for tissues of the sympathetic nervous system and related tumors. The radiolabeled forms are used as antineoplastic agents and radioactive imaging agents. (Merck Index, 12th ed) MIBG serves as a neuron-blocking agent which has a strong affinity for, and retention in, the adrenal medulla and also inhibits ADP-ribosyltransferase.
A progressive, degenerative neurologic disease characterized by a TREMOR that is maximal at rest, retropulsion (i.e. a tendency to fall backwards), rigidity, stooped posture, slowness of voluntary movements, and a masklike facial expression. Pathologic features include loss of melanin containing neurons in the substantia nigra and other pigmented nuclei of the brainstem. LEWY BODIES are present in the substantia nigra and locus coeruleus but may also be found in a related condition (LEWY BODY DISEASE, DIFFUSE) characterized by dementia in combination with varying degrees of parkinsonism. (Adams et al., Principles of Neurology, 6th ed, p1059, pp1067-75)
The transfer of a neoplasm from one organ or part of the body to another remote from the primary site.
Benign and malignant central nervous system neoplasms derived from glial cells (i.e., astrocytes, oligodendrocytes, and ependymocytes). Astrocytes may give rise to astrocytomas (ASTROCYTOMA) or glioblastoma multiforme (see GLIOBLASTOMA). Oligodendrocytes give rise to oligodendrogliomas (OLIGODENDROGLIOMA) and ependymocytes may undergo transformation to become EPENDYMOMA; CHOROID PLEXUS NEOPLASMS; or colloid cysts of the third ventricle. (From Escourolle et al., Manual of Basic Neuropathology, 2nd ed, p21)
A number of small lung lesions characterized by small round masses of 2- to 3-mm in diameter. They are usually detected by chest CT scans (COMPUTED TOMOGRAPHY, X-RAY). Such nodules can be associated with metastases of malignancies inside or outside the lung, benign granulomas, or other lesions.
Soft tissue tumors or cancer arising from the mucosal surfaces of the LIP; oral cavity; PHARYNX; LARYNX; and cervical esophagus. Other sites included are the NOSE and PARANASAL SINUSES; SALIVARY GLANDS; THYROID GLAND and PARATHYROID GLANDS; and MELANOMA and non-melanoma skin cancers of the head and neck. (from Holland et al., Cancer Medicine, 4th ed, p1651)
Negative test results in subjects who possess the attribute for which the test is conducted. The labeling of diseased persons as healthy when screening in the detection of disease. (Last, A Dictionary of Epidemiology, 2d ed)
Theoretical representations that simulate the behavior or activity of biological processes or diseases. For disease models in living animals, DISEASE MODELS, ANIMAL is available. Biological models include the use of mathematical equations, computers, and other electronic equipment.
Tumors or cancer located in bone tissue or specific BONES.
Tumors or cancer of the ESOPHAGUS.
A mutant strain of Rattus norvegicus without a thymus and with depressed or absent T-cell function. This strain of rats may have a small amount of hair at times, but then lose it.
Peptides generated from AMYLOID BETA-PEPTIDES PRECURSOR. An amyloid fibrillar form of these peptides is the major component of amyloid plaques found in individuals with Alzheimer's disease and in aged individuals with trisomy 21 (DOWN SYNDROME). The peptide is found predominantly in the nervous system, but there have been reports of its presence in non-neural tissue.
A general term for various neoplastic diseases of the lymphoid tissue.
Ring compounds having atoms other than carbon in their nuclei. (Grant & Hackh's Chemical Dictionary, 5th ed)
A set of forebrain structures common to all mammals that is defined functionally and anatomically. It is implicated in the higher integration of visceral, olfactory, and somatic information as well as homeostatic responses including fundamental survival behaviors (feeding, mating, emotion). For most authors, it includes the AMYGDALA; EPITHALAMUS; GYRUS CINGULI; hippocampal formation (see HIPPOCAMPUS); HYPOTHALAMUS; PARAHIPPOCAMPAL GYRUS; SEPTAL NUCLEI; anterior nuclear group of thalamus, and portions of the basal ganglia. (Parent, Carpenter's Human Neuroanatomy, 9th ed, p744; NeuroNames, http://rprcsgi.rprc.washington.edu/neuronames/index.html (September 2, 1998)).
Tumors or cancer of the LIVER.
Fever in which the etiology cannot be ascertained.
The movement and the forces involved in the movement of the blood through the CARDIOVASCULAR SYSTEM.
A rare metal element with a blue-gray appearance and atomic symbol Ge, atomic number 32, and atomic weight 72.63.
BENZOIC ACID amides.
An imbalance between myocardial functional requirements and the capacity of the CORONARY VESSELS to supply sufficient blood flow. It is a form of MYOCARDIAL ISCHEMIA (insufficient blood supply to the heart muscle) caused by a decreased capacity of the coronary vessels.
An inhibitor of DOPA DECARBOXYLASE, preventing conversion of LEVODOPA to dopamine. It is used in PARKINSON DISEASE to reduce peripheral adverse effects of LEVODOPA. It has no antiparkinson actions by itself.
A malignant epithelial tumor with a glandular organization.
Accumulations of extracellularly deposited AMYLOID FIBRILS within tissues.
A colorless, odorless gas that can be formed by the body and is necessary for the respiration cycle of plants and animals.
Tumors or cancer of the human BREAST.
Compounds with a six membered aromatic ring containing NITROGEN. The saturated version is PIPERIDINES.
Mutant mice homozygous for the recessive gene "nude" which fail to develop a thymus. They are useful in tumor studies and studies on immune responses.
The phylogenetically newer part of the CORPUS STRIATUM consisting of the CAUDATE NUCLEUS and PUTAMEN. It is often called simply the striatum.
Small-scale tests of methods and procedures to be used on a larger scale if the pilot study demonstrates that these methods and procedures can work.
Decrease in the size of a cell, tissue, organ, or multiple organs, associated with a variety of pathological conditions such as abnormal cellular changes, ischemia, malnutrition, or hormonal changes.
Electronic instruments that produce photographs or cathode-ray tube images of the gamma-ray emissions from organs containing radionuclide tracers.
A neural crest tumor usually derived from the chromoreceptor tissue of a paraganglion, such as the carotid body, or medulla of the adrenal gland (usually called a chromaffinoma or pheochromocytoma). It is more common in women than in men. (Stedman, 25th ed; from Segen, Dictionary of Modern Medicine, 1992)
Pathologic conditions affecting the BRAIN, which is composed of the intracranial components of the CENTRAL NERVOUS SYSTEM. This includes (but is not limited to) the CEREBRAL CORTEX; intracranial white matter; BASAL GANGLIA; THALAMUS; HYPOTHALAMUS; BRAIN STEM; and CEREBELLUM.
A technetium imaging agent used to reveal blood-starved cardiac tissue during a heart attack.
The worsening of a disease over time. This concept is most often used for chronic and incurable diseases where the stage of the disease is an important determinant of therapy and prognosis.
Gases, fumes, vapors, and odors escaping from the cylinders of a gasoline or diesel internal-combustion engine. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed & Random House Unabridged Dictionary, 2d ed)
Freedom from activity.
A chronic inflammatory process that affects the AORTA and its primary branches, such as the brachiocephalic artery (BRACHIOCEPHALIC TRUNK) and CAROTID ARTERIES. It results in progressive arterial stenosis, occlusion, and aneurysm formation. The pulse in the arm is hard to detect. Patients with aortitis syndrome often exhibit retinopathy.
The amount of radiation energy that is deposited in a unit mass of material, such as tissues of plants or animal. In RADIOTHERAPY, radiation dosage is expressed in gray units (Gy). In RADIOLOGIC HEALTH, the dosage is expressed by the product of absorbed dose (Gy) and quality factor (a function of linear energy transfer), and is called radiation dose equivalent in sievert units (Sv).
The rate dynamics in chemical or physical systems.
A carcinoma derived from stratified SQUAMOUS EPITHELIAL CELLS. It may also occur in sites where glandular or columnar epithelium is normally present. (From Stedman, 25th ed)

Uptakes and images of 38K in rabbit heart, kidney, and brain. (1/7585)

The purpose of this study was to evaluate the kinetics and image quality of positron-emitting 38K (half-life, 7.6 min) and high-resolution small-animal PET in the heart, kidney, and brain of rabbits. METHODS: Studies were performed with 18 closed-chest anesthetized rabbits at baseline and during infusions of adenosine (0.2 mg/kg/min) and propranolol (0.5-1.0 mg/kg intravenously) using high-resolution small-animal PET. 38K was injected intravenously and dynamic PET imaging of the heart, kidney, or brain was performed for 3 min. Colored microspheres were injected into the left ventricle to measure organ blood flow. Arterial blood was withdrawn directly from the femoral artery, and, after the animals were killed, 38K activities in each organ were measured directly with a well counter. Uptake of 38K was calculated by dividing the 38K activities in each organ by the integral of the input function. The extraction fraction of 38K was estimated by dividing the uptake of 38K in each organ by the organ blood flow, measured by microspheres. RESULTS: The left ventricular myocardium and kidney were clearly visualized, but there was no visual 38K uptake in the brain. For the heart, kidney, and brain, respectively, average blood flow was 2.91 +/- 1.29, 5.49 +/- 0.71, and 0.57 +/- 0.11 mL/min/g, and the extraction fraction of 38K at baseline was 0.55 +/- 0.13, 0.48 +/- 0.13, and 0.022 +/- 0004. The Renkin-Crone model fit the relation between myocardial extraction and flow under a wide range of myocardial blood flow (r = 0.89). CONCLUSION: 38K is a suitable tracer for noninvasively showing the potassium kinetics of the heart, kidney, and brain by PET imaging.  (+info)

Controversies in the radiotherapeutic management of cervical cancer. (2/7585)

Radiotherapy is a critical component of treatment for many patients with cervical cancer. The role of concurrent cisplatin-based chemotherapy in the majority of cases where radiotherapy is indicated has been established. However, optimal planning and delivery of radiotherapy require attention to multiple factors beyond combined-modality chemoradiation and the continuing search for novel and effective synergistic systemic agents. Several important issues surrounding radiotherapy for cervical cancer that require clarification include the following: the effect of anemia and tumor hypoxia on outcome and their potential as therapeutic targets, the appropriate incorporation of contemporary imaging and high-technology treatment planning systems in routine clinical practice, the role of prophylactic para-aortic radiation, and the role of radioprotectors. Ongoing and newly proposed studies are expected to provide insights into these questions, which will ultimately lead to enhanced radiotherapeutic and overall care for patients with cervical cancer.  (+info)

Workflow management of HIS/RIS textual documents with PACS image studies for neuroradiology. (3/7585)

Reviewing brain tumor patients' complete medical record is a daunting task for any clinician. In current practice, the radiologist examines the most recent documents and then dictates an assessment of the patient's condition based on a review of the most current imaging study and compared with the most recent previous image study. Occasionally, the radiologist searches other clinical documents when more precise detail is needed. The purpose of this research is to develop effective methods to review all of the pertinent information in a patient medical record incorporating HIS (Hospital Information Systems), RIS (Radiology Information Systems) and PACS (Picture Archiving and Communications Systems) information in three distinct ways: filtering the document worklist for pertinent clinical data, identification of key clusters of clinical information, and an automatic hanging protocol that displays the MR images for optimal image comparison.  (+info)

Radiation-induced medulloblastoma in an adult: a functional imaging study. (4/7585)

We describe functional imaging findings using MRI, 1H-Magnetic resonance spectroscopy and positron emission tomography in a case of radiation-induced medulloblastoma following radiotherapy for pineal gland tumor. MRS showed a prominent choline peak; FDG, 11C-Met and 11C-Choline PET showed a minimal glucose, increased methionine and choline uptake.  (+info)

Hypoxia and glucose metabolism in malignant tumors: evaluation by [18F]fluoromisonidazole and [18F]fluorodeoxyglucose positron emission tomography imaging. (5/7585)

PURPOSE: The aim of this study is to compare glucose metabolism and hypoxia in four different tumor types using positron emission tomography (PET). (18)F-labeled fluorodeoxyglucose (FDG) evaluates energy metabolism, whereas the uptake of (18)F-labeled fluoromisonidazole (FMISO) is proportional to tissue hypoxia. Although acute hypoxia results in accelerated glycolysis, cellular metabolism is slowed in chronic hypoxia, prompting us to look for discordance between FMISO and FDG uptake. EXPERIMENTAL DESIGN: Forty-nine patients (26 with head and neck cancer, 11 with soft tissue sarcoma, 7 with breast cancer, and 5 with glioblastoma multiforme) who had both FMISO and FDG PET scans as part of research protocols through February 2003 were included in this study. The maximum standardized uptake value was used to depict FDG uptake, and hypoxic volume and maximum tissue:blood ratio were used to quantify hypoxia. Pixel-by-pixel correlation of radiotracer uptake was performed on coregistered images for each corresponding tumor plane. RESULTS: Hypoxia was detected in all four patient groups. The mean correlation coefficients between FMISO and FDG uptake were 0.62 for head and neck cancer, 0.47 for breast cancer, 0.38 for glioblastoma multiforme, and 0.32 for soft tissue sarcoma. The correlation between the overall tumor maximum standardized uptake value for FDG and hypoxic volume was small (Spearman r = 0.24), with highly significant differences among the different tumor types (P < 0.005). CONCLUSIONS: Hypoxia is a general factor affecting glucose metabolism; however, some hypoxic tumors can have modest glucose metabolism, whereas some highly metabolic tumors are not hypoxic, showing discordance in tracer uptake that can be tumor type specific.  (+info)

Imaging the pharmacodynamics of HER2 degradation in response to Hsp90 inhibitors. (6/7585)

The development of therapeutic inhibitors of key signaling pathways has been hampered by the inability to assess the effect of a drug on its target in the patient. 17-allylaminogeldanamycin (17-AAG) is the first Hsp90 inhibitor to be tested in a clinical trial. It causes the degradation of HER2 and other Hsp90 targets, and has antitumor activity in preclinical models. We have developed a method for imaging the inhibition of Hsp90 by 17-AAG. We labeled an F(ab')2 fragment of the anti-HER2 antibody Herceptin with 68Ga, a positron emitter, which allows the sequential positron-emission tomographic imaging of HER2 expression. We have used this method to quantify as a function of time the loss and recovery of HER2 induced by 17-AAG in animal tumors. This approach allows noninvasive imaging of the pharmacodynamics of a targeted drug and will facilitate the rational design of combination therapy based on target inhibition.  (+info)

Effect of pravastatin on low-density lipoprotein oxidation and myocardial perfusion in young adults with type 1 diabetes. (7/7585)

OBJECTIVE: Diabetes has been associated with increased oxidative stress and impaired vascular function. Statins have been shown to reduce low-density lipoprotein (LDL) oxidizability and improve myocardial perfusion in hypercholesterolemic nondiabetic subjects. We studied whether pravastatin decreases LDL oxidation and improves myocardial perfusion in normocholesterolemic subjects with type 1 diabetes. METHODS AND RESULTS: In this randomized, double-blind study, myocardial perfusion was measured at rest and during dipyridamole stimulation with positron emission tomography and [15O]H2O during hyperinsulinemic euglycemia in 42 patients (age 30+/-6 years; LDL cholesterol 2.48+/-0.57 mmol/L) before and after 4-month treatment with pravastatin 40 mg/d or placebo. In addition, 12 healthy nondiabetic subjects were studied. LDL oxidation was measured by determining the level of baseline diene conjugation in lipids extracted from LDL. The level of LDL oxidation was similar in the pravastatin and placebo groups before treatment (23.9+/-4.6 versus 25.6+/-9.5 micromol/L, respectively) and decreased significantly during pravastatin treatment to 19.5+/-5.0 micromol/L (P<0.005). Myocardial perfusion reserve was significantly lower in diabetic patients compared with controls (4.15+/-1.29 versus 5.31+/-1.86, P<0.05) and did not change after treatment. Glycemic control and insulin sensitivity remained unchanged during treatment. CONCLUSIONS: Pravastatin treatment, resulting in decreased LDL oxidation, did not improve myocardial perfusion reserve in subjects with type 1 diabetes.  (+info)

First (18)F-labeled tracer suitable for routine clinical imaging of sst receptor-expressing tumors using positron emission tomography. (8/7585)

PURPOSE: Despite excellent radionuclide characteristics, no (18)F-labeled peptides are available for quantitative peptide receptor mapping using positron emission tomography (PET) so far, mainly due to time-consuming multistep radiosyntheses with limited overall yields. A newly developed two-step chemoselective conjugation method allows rapid and high-yield [(18)F]fluorination of peptides via oxime formation and was applied for the synthesis of new (18)F-labeled carbohydrated Tyr(3)-octreotate (TOCA) analogs with optimized pharmacokinetics suitable for clinical routine somatostatin-receptor (sst) imaging. EXPERIMENTAL DESIGN: (18)F-labeled glucose (Gluc-S-) and cellobiose (Cel-S-) derivatives of aminooxy-functionalized TOCA were synthesized via oxime formation with 4-[(18)F]fluorobenzaldehyde ([(18)F]FBOA-peptides). Both the in vitro internalization profile of Gluc-S-Dpr([(18)F]FBOA)TOCA and Cel-S-Dpr([(18)F]FBOA)TOCA in hsst(2)-expressing Chinese hamster ovary cells (dual tracer protocol) and their biodistribution in AR42J tumor-bearing mice were investigated and compared with two [(18)F]fluoropropionylated ([(18)F]FP) analogs, Gluc-Lys([(18)F]FP)TOCA and Gluc-S-Dpr([(18)F]FP)TOCA. RESULTS: In contrast to [(18)F]FP-labeling (3 h), chemo-selective [(18)F]FBOA-formation (50 min) afforded the respective radiopeptides in high yields (65-85%). In vitro, Gluc-S-Dpr([(18)F]FBOA)TOCA and Cel-S-Dpr([(18)F]FBOA)-TOCA showed high internalization (139 +/- 2 and 163 +/- 8 of the reference [(125)I]Tyr(3)-octreotide, respectively), which was reflected by high tumor accumulation in vivo [21.8 +/- 1.4 and 24.0 +/- 2.5% of injected dose/g (1 h), respectively]. How-ever, only Cel-S-Dpr([(18)F]FBOA)TOCA and Gluc-S-Dpr([(18)F]FP)TOCA (tumor: 15.1 +/- 1.5% of injected dose/g) with its very low accumulation in all of the nontarget organs showed improved tumor:organ ratios compared with Gluc-Lys([(18)F]FP)TOCA. For Cel-S-Dpr([(18)F]FBOA)TOCA,tumor:organ ratios (1 h) were 42:1, 27:1, 15:1, 3:1, and 208:1 for blood, liver, intestine, kidney, and muscle, respectively. CONCLUSION: Due to the fast and high-yield chemoselective radiofluorination strategy and to its excellent pharmacokinetics, Cel-S-Dpr([(18)F]FBOA)TOCA represents the first tracer suitable for routine clinical application in PET somatostatin receptor imaging.  (+info)

Looking for Positron-emission tomography? Find out information about Positron-emission tomography. see PET scan PET scan or positron emission tomography , a medical imaging technique that monitors metabolic, or biochemical, activity in the brain and other... Explanation of Positron-emission tomography
see also Fluoroethyl Tyrosine Positron Emission Tomography Besides the advantages of hybrid positron emission tomography-computed tomography imaging, this dual-modality scanning may produce their own specific artifacts due to different causes, such as metallic implants, respiratory motion, contrast medium and truncation. Proper patient preparation is required to minimize the potential artifactual uptake patterns that make reporting difficult. It is important to learn about proper quality control, imaging and reconstruction and to be familiar with potential artifacts and, pitfalls for the accurate interpretation of F-fluorodeoxyglucose positron emission tomography-computed tomography 1). It is a highly sensitive and specific modality for detection of bone metastases in patients with high-risk prostate cancer. It is more specific than 18F-Fluoride PET alone and more sensitive and specific than planar and SPECT bone scintigraphy (BS). Detection of bone metastases is improved by SPECT compared with ...
We examined lateral geniculate nucleus (LGN) degeneration as an indicator for possible diagnosis of glaucoma in experimental glaucoma monkeys using positron emission tomography (PET). Chronic intraocular pressure (IOP) elevation was induced by laser trabeculoplasty in the left eyes of 5 cynomolgus monkeys. Glial cell activation was detected by PET imaging with [11C]PK11195, a PET ligand for peripheral-type benzodiazepine receptor (PBR), before and at 4 weeks after laser treatment (moderate glaucoma stage). At mild, moderate, and advanced experimental glaucoma stages (classified by histological changes based on the extent of axonal loss), brains were stained with cresyl violet, or antibodies against PBR, Iba-1 (a microglial marker), and GFAP (an activated astrocyte marker). In laser-treated eyes, IOP was persistently elevated throughout all observation periods. PET imaging showed increased [11C]PK11195 binding potential in the bilateral LGN at 4 weeks after laser treatment; the increase in the
This phase II trial studies how well chemotherapy based on positron emission tomography (PET) scan works in treating patients with stage I or stage II Hodgkin lymphoma. Drugs used in chemotherapy work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing. Giving more than one drug (combination chemotherapy) may kill more cancer cells. Radiation therapy uses high energy x-rays to kill cancer cells. Giving combination chemotherapy together with radiation therapy may kill more cancer cells and allow doctors to save the part of the body where the cancer started. Comparing results of diagnostic procedures, such as PET scan, done before, during, and after chemotherapy may help doctors predict a patients response to treatment and help plan the best treatment ...
This phase II trial studies how well chemotherapy based on positron emission tomography (PET) scan works in treating patients with stage I or stage II Hodgkin lymphoma. Drugs used in chemotherapy work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing. Giving more than one drug (combination chemotherapy) may kill more cancer cells. Radiation therapy uses high energy x-rays to kill cancer cells. Giving combination chemotherapy together with radiation therapy may kill more cancer cells and allow doctors to save the part of the body where the cancer started. Comparing results of diagnostic procedures, such as PET scan, done before, during, and after chemotherapy may help doctors predict a patients response to treatment and help plan the best treatment ...
Numerous radiolabeled peptides have been utilized for in vivo imaging of a variety of cell surface receptors. For applications in PET using [(18)F]fluorine, peptides are radiolabeled via a prosthetic group approach. We previously developed solution-phase (18)F-click radiolabeling and solid-phase radiolabeling using 4-[(18)F]fluorobenzoic and 2-[(18)F]fluoropropionic acids. Here we compare the three different radiolabeling approaches and report the effects on PET imaging and pharmacokinetics. The prosthetic groups did have an effect; metabolites with significantly different polarities were observed.
With the increasing utilization of integrated positron-emission tomography/computed tomography (PET/CT) using | A. D. Culverwell, Andrew Scarsbrook, Fahmid U. Cho | Clinical Radiology |
Abstract: Objective To evaluate the correlation of the positron emission tomography/magnetic resonance imaging (PET/MR) parameters with the pathological differentiation of head and neck squamous cell carcinoma(HNSCC) and the diagnostic efficiencies of PET/MR parameters. Methods Patients with clinical suspicion of HNSCC were included and underwent PET/MR scan. HNSCC was pathologically confirmed in all these patients. The PET/MR examination included PET and MR sequences of diffusion-weighted imaging (DWI) and T2-and T1-weighted imaging. The multiple parameters of PET/MR included the mean values of apparent diffusion coefficient(ADCmean) and the maximum and mean values of standardized uptake value (SUVmax and SUVmean) were measured and estimated. The correlations of all the parameters and distribution between the different tumor differentiation groups were analyzed. Logistic regression was utilized to build the model as the PET/MR combined parameter for predicting the differentiation by multiple ...
Positron Emission Tomography (PET) Scanners Market size will reach xx million US$ by 2029, from xx million US$ in 2018, at a CAGR of xx% during the forecast period. In this study, 2018 has been considered as the base year and 2016 - 2026 as the forecast period to estimate the market size for Positron Emission Tomography (PET) Scanners .. This industry study presents the Positron Emission Tomography (PET) Scanners Market size, historical breakdown data 2014-2019 and forecast 2016 - 2026. The Private Plane production, revenue and market share by manufacturers, key regions and type; The consumption of Positron Emission Tomography (PET) Scanners Market in volume terms are also provided for major countries (or regions), and for each application and product at the global level.. This Press Release will help you to understand the Volume, growth with Impacting Trends. Click HERE To get SAMPLE PDF (Including Full TOC, Table & Figures) at https://www.xploremr.com/connectus/sample/879. Positron Emission ...
The presence of bulky disease in Hodgkin lymphoma (HL), traditionally defined with a 1-dimensional measurement, can change a patients risk grouping and thus the treatment approach. We hypothesized that 3-dimensional measurements of disease burden obtained from baseline 18F-fluorodeoxyglucose positron emission tomography-computed tomography (PET-CT) scans, such as metabolic tumor volume (MTV) and total lesion glycolysis (TLG), would more accurately risk stratify patients. To test this hypothesis, we reviewed pretreatment PET-CT scans of patients with stage I-II HL treated at our institution between 2003-2013. Disease was delineated on pre-chemotherapy PET-CT scans by two methods: 1) manual contouring, and 2) sub-thresholding of these contours to give the tumor volume with SUV≥2.5. MTV and TLG were extracted from the threshold volumes (MTVt, TLGt), as well as from the manually contoured soft-tissue volumes (MTVst, TLGst). At a median follow-up time of 4.96 years for the 267 patients evaluated, ...
Objective: The objective of this study was to compare the accuracy of calculating the primary tumor volumes using a gradient-based method and fixed threshold methods on the standardized uptake value (SUV) maps and the net influx of FDG (Ki) maps from positron emission tomography-computed tomography (PET-CT) images.. Materials and Methods: Newly diagnosed patients with head and neck cancer were recruited, and dynamic PET-CT scan and T2-weighted magnetic resonance imaging were performed. The maps of Ki and SUV were calculated from PET-CT images. The tumor volumes were calculated using a gradient-based method and a fixed threshold method at 40% of maximal SUV or maximal Ki. Four kinds of volumes, VOLKi-Gra (from the Ki maps using the gradient-based method), VOLKi-40% (from the Ki maps using the threshold of 40% maximal Ki), VOLSUV-Gra (from the SUV maps using the gradient-based method), and VOLSUV-40% (from the SUV maps using the threshold of 40% maximal SUV), were acquired and compared with VOLMRI ...
Using statistical methods the reconstruction of positron emission tomography (PET) images can be improved by high-resolution anatomical information obtaine
Prostate cancer is a common cancer in men and continues to be a major health problem. Imaging plays an essential role in the clinical management of patients. An important goal for prostate cancer imaging is more accurate disease characterization through the synthesis of anatomic, functional, and molecular imaging information. Developments in imaging technologies, specifically magnetic resonance imaging (MRI) and positron emission tomography (PET)/computed tomography (CT), have improved the detection rate of prostate cancer. MRI has improved lesion detection and local staging. Furthermore, MRI allows functional assessment with techniques such as diffusion-weighted MRI, MR spectroscopy, and dynamic contrast-enhanced MRI. The most common PET radiotracer, (18)F-fluorodeoxyglucose, is not very useful in prostate cancer. However, in recent years other PET tracers have improved the accuracy of PET/CT imaging of prostate cancer. Among these, choline (labeled with (18)F or (11)C), (11)C-acetate, and ...
TY - JOUR. T1 - Follow-up of radial arterial catheterization for positron emission tomography studies. AU - Jons, Peter H.. AU - Ernst, Monique. AU - Hankerson, James. AU - Hardy, Kristina. AU - Zametkin, Alan J.. PY - 1997/6/24. Y1 - 1997/6/24. N2 - Radial arterial catheterization is needed for repeated arterial blood samples to construct tracer input curves of positron emission tomography (PET) scans (Herscovitch [1993]: Rheum Dis Clin North Am 19:765-794). Complications resulting from such short-term catheterizations are rare. Sixteen investigators followed 106 subjects who had arterial lines placed in the context of a PET study. Abnormalities were reported in 8 of 106 (7.5%) cases. Of these eight cases, three (37.5%) were inpatients diagnosed with anorexia nervosa, a condition that may represent a risk factor. All abnormalities were benign, did not affect motor function, and did not require medical intervention.. AB - Radial arterial catheterization is needed for repeated arterial blood ...
METHODS: The current study included 132 patients, who were operated on between July 2007 and April 2013, for renal cell carcinoma (RCC) and received 18FDG-PET/CT scans for restaging purposes. Ninety (68.2%) of the patients were male and 42 (31.8%) were female, with a mean age of 60.7 years and standard deviation ±11.9 (range min: 28, max: 86). The patients were required to fast for 6 hours prior to scanning, and whole-body PET scanning from the skull base to the upper thighs was performed approximately 1 hour after the intravenous injection of 555 MBq of F-18 FDG. Whole body CT scanning was performed in the cranio-caudal direction. FDG-PET images were reconstructed using CT data for attenuation correction. Suspicious recurrent or metastatic lesions were confirmed by histopathology or clinical follow-up ...
We hypothesized that quantitative PET parameters may have predictive value beyond that of traditional clinical factors such as the International Prognostic Score (IPS) among Hodgkins disease (HD) patients. Thirty HD patients treated at presentation or relapse had staging and interim-treatment PET-CT scans. The majority of patients (53%) had stage III-IV disease and 67% had IPS ≥ 2. Interim-treatment scans were performed at a median of 55 days from the staging PET-CT. Chemotherapy regimens used: Stanford V (67%), ABVD (17%), VAMP (10%), or BEACOPP (7%). Hypermetabolic tumor regions were segmented semiautomatically and the metabolic tumor volume (MTV), mean standardized uptake value (SUVmean), maximum SUV (SUVmax) and integrated SUV (iSUV) were recorded. We analyzed whether IPS, absolute value PET parameters or the calculated ratio of interim- to pre-treatment PET parameters were associated with progression free survival (PFS) or overall survival (OS). Median follow-up of the study group was 50 months.
TY - JOUR. T1 - A hybrid nanoparticle probe for dual-modality positron emission tomography and magnetic resonance imaging. AU - Choi, Jin Sil. AU - Park, Jeong Chan. AU - Nah, Hyunsoo. AU - Woo, Seungtae. AU - Oh, Jieun. AU - Kim, Kyeong Min. AU - Cheon, Gi Jeong. AU - Chang, Yongmin. AU - Yoo, Jeongsoo. AU - Cheon, Jinwoo. PY - 2008/8/4. Y1 - 2008/8/4. N2 - (Figure Presented) Creating a good image: A probe for combined positron emission tomography (PET) and magnetic resonance imaging (MRI) has high colloidal stability and demonstrates facile conjugation ability. Sentinel lymph nodes are clearly identified in the fusion image (see picture; I: injection site) because of the complementary nature of the techniques, which makes accurate anatomical information and fault-free diagnosis possible.. AB - (Figure Presented) Creating a good image: A probe for combined positron emission tomography (PET) and magnetic resonance imaging (MRI) has high colloidal stability and demonstrates facile conjugation ...
Positron emission tomography (PET) scan - Overview covers definition, risks, results of this imaging test used to diagnose disease and assess treatment.
As a nuclear approach, Positron Emission Tomography (PET) is a functional imaging technique which is based on the detection of gamma ray pairs emitted by a positron-emitting radionuclide. There are certain limitations to this technique such as normal tissue uptake. Therefore, it has been recommended that patients prepare before scanning. Fasting for a short while before PET imaging is an example of such preparation. In this paper, we attempted to collect the studies evaluating the effects of fasting in the three sections of cardiac, brain and abdominal PET imaging. Conclusively, we found that the effects of fasting on PET imaging can be different depending on the type of PET scanning, radiotracer, patients diseases, fasting duration and in case of any additional dietary plans. It is proposed that further study be conducted on this subject in order to determine such effects in more detail.
We offer in vivo micro positron emission tomography (PET) study design, execution and data analysis across a broad spectrum of disease models and analytic techniques. Our imaging experts and disease area experts design and execute PET studies for maximal clinical relevance, statistical power, and throughput. Our PET studies are performed using a Siemens Inveon scanner.. Positron emission tomography (PET) is a nuclear medicine imaging technique that generates 3D images of an injected PET radioisotope-labeled molecule in the body. Radiotracer distribution is detected via emitted gamma photons resulting from positron-electron annihilation. PET imaging in the preclinical setting (micro-PET) is increasingly being used in drug discovery to study disease biology and biodistribution and kinetics of biologic molecules.. ...
Press Release issued Sep 7, 2017: Future Market Insights delivers key insights on the global Positron Emission Tomography scanners market in a new report titled, Positron Emission Tomography (PET) Scanners Market: Global Industry Analysis and Opportunity Assessment, 2016-2026. In terms of revenue, the global Positron Emission Tomography (PET) scanners market is projected to register a healthy CAGR of 4.7% over the forecast period.
OBJECTIVE: The serotonin transporter (5-HTT) is a key target for selective serotonin reuptake inhibitors and may be involved in the pathophysiology of major depression. It is now possible to image 5-HTT directly in the human brain, but results from studies of acutely depressed patients have been inconsistent. The purpose of this study was to determine whether abnormalities in 5-HTT might be present in recovered depressed patients. METHOD: The authors measured the binding potential of 5-HTT using [11C]DASB in conjunction with positron emission tomography (PET) in 24 medication-free, recovered depressed male patients and 20 healthy male comparison subjects. The regional estimates of binding potential were obtained using a metabolite-corrected plasma input function method followed by Logan analysis, with the cerebellum as a reference region. RESULTS: The authors found no significant difference in the binding potential of [11C]DASB between the recovered depressed patients and healthy comparison subjects in
In diabetic cardiomyopathy, left ventricular (LV) diastolic dysfunction is one of the earliest signs of cardiac involvement prior to the definitive development of heart failure (HF). We aimed to explore the LV diastolic function using electrocardiography (ECG)-gated \(^{18}\)F-fluorodeoxyglucose positron emission tomography (\(^{18}\)F-FDG PET) imaging beyond the assessment of cardiac glucose utilization in a diabetic rat model. ECG-gated \(^{18}\)F-FDG PET imaging was performed in a rat model of type 2 diabetes (ZDF fa/fa) and ZL control rats at age of 13 weeks (n=6, respectively). Under hyperinsulinemic-euglycemic clamp to enhance cardiac activity, \(^{18}\)F-FDG was administered and subsequently, list-mode imaging using a dedicated small animal PET system with ECG signal recording was performed. List-mode data were sorted and reconstructed into tomographic images of 16 frames per cardiac cycle. Left ventricular functional parameters (systolic: LV ejection fraction (EF), heart rate (HR) vs. diastolic:
The semi-quantitative estimate standardised uptake value ratios (SUVR) correlate well with specific binding of the tracer expressed as distribution volume ratios (DVR) for the tau positron emission tomography tracer [18F]AV-1451 uptake and are therefore widely used as proxy for tracer binding. With regard to tracer kinetic modelling, there exists a time point when SUVR deviates minimally from DVR, occurring when the specific binding reaches a transient equilibrium . Here, we have investigated whether the time to equilibrium affects the agreement between SUVR and DVR across different brain regions. We show that the time required to reach equilibrium differs across brain regions, resulting in region-specific biases. However, even though the 80-100 min post-injection time window did not show the smallest bias numerically, the disagreement between SUVR and DVR varied least between regions during this time. In conclusion, our findings suggest a regional component to the bias of SUVR related to the ...
The current study showed that CIRT performed at our institute could treat inoperable bone and soft-tissue tumors with an acceptable recurrence rate as low as that in previous reports [8-10]. CIRT induced a significant decrease of FDG accumulation in the target tumors, and the post-Tx SUVmax in the recurrence group was significantly higher than that in the no recurrence group. These results suggested that CIRT could downregulate the tumor metabolism, and the tumors that exhibited decreased glucose transport activity following CIRT showed a reduced risk of local recurrence. Meanwhile, the tumor size was hardly changed after CIRT, and seemed to be inappropriate for evaluating the response to the treatment, which was consistent with previous reports showing that the SUV from FDG-PET/CT was superior to changes in tumor size for predicting tumor necrosis induced by neoadjuvant chemotherapy [12].. While a favorable effect of CIRT to reduce the tumor activity was shown, the present study also showed ...
In diabetic cardiomyopathy, left ventricular (LV) diastolic dysfunction is one of the earliest signs of cardiac involvement prior to the definitive development of heart failure (HF). We aimed to explore the LV diastolic function using electrocardiography (ECG)-gated \(^{18}\)F-fluorodeoxyglucose positron emission tomography (\(^{18}\)F-FDG PET) imaging beyond the assessment of cardiac glucose utilization in a diabetic rat model. ECG-gated \(^{18}\)F-FDG PET imaging was performed in a rat model of type 2 diabetes (ZDF fa/fa) and ZL control rats at age of 13 weeks (n=6, respectively). Under hyperinsulinemic-euglycemic clamp to enhance cardiac activity, \(^{18}\)F-FDG was administered and subsequently, list-mode imaging using a dedicated small animal PET system with ECG signal recording was performed. List-mode data were sorted and reconstructed into tomographic images of 16 frames per cardiac cycle. Left ventricular functional parameters (systolic: LV ejection fraction (EF), heart rate (HR) vs. ...
Purpose/Introduction: Use of brain PET studies in multicentre trials or as a quantitative imaging biomarker for (automated) differential diagnosis of neurogenerative diseases require harmonized quantitative image characteristics. In this study we explored the feasibility of developing a harmonizing performance standard for brain PET studies on state of the art PET/CT systems. Subjects & Methods: In this exploratory study 6 state of the art PET/CT systems were included: Philips Gemini TF, Ingenuity TF and digital Vereos systems, 2 Siemens Biograph mCTs and a GE 710. Only systems with EARL compliant (calibration and image quality) performances were included. A 30 min dynamic PET scan of the 3D Hoffmann brain phantom was acquired. The phantom was filled with an exact known FDG stock solution (aimed at 40 kBq/mL). Each scan was reconstructedusing various clinically relevant reconstruction settings. Depending on PET/CT system reconstruction settings were varied as follows: time of flight (TOF) ...
TY - JOUR. T1 - Differential diagnosis of lung tumor with positron emission tomography. T2 - A prospective study. AU - Kubota, K.. AU - Matsuzawa, T.. AU - Fujiwara, T.. AU - Ito, M.. AU - Hatazawa, J.. AU - Ishiwata, K.. AU - Iwata, Ren. AU - Ido, T.. PY - 1990/12/1. Y1 - 1990/12/1. N2 - To predict the nature of non-calcifying lung tumors, we performed a prospective study of 46 cases with L-[methyl 11C]methionine (MET, 24 cases) and 18F-fluorodeoxyglucose (FDG, 22 cases) using positron emission tomography (PET). Mean tumor/muscle radioactivity ratios are 5.3 ± 2.0 (n = 14) for malignant and 1.9 ± 0.9 (n = 10) for benign with MET (p , 0.001), and 4.4 ± 2.2 (n = 12) and 1.5 ± 0.3 (n = 10), respectively, with FDG (p , 0.001). The ratios indicate that malignant tumors have higher metabolic demand than benign lesions. Tumors less than 1 cm in diameter were difficult to accurately evaluate due to PET resolution. Compared to the diagnosis at pathology, the MET study showed a sensitivity of 93% ...
Single arm, open label, Phase IB study of indibulin capsules in subjects with advanced solid tumors; eligible subjects will have a baseline PET scan sho
The treatment of patients with glioma depended on the nature of the lesion and on histological grade of the tumor. Positron emission tomography (PET) using 13N-ammonia (NH3), 11C-methionine (MET) and 18F-fluorodeoxyglucose (FDG) have been used to assess brain tumors. Our aim was to compare their diagnostic accuracies in patients with suspected cerebral glioma. Ninety patients with suspicion of glioma based on previous CT/MRI, who underwent NH3 PET, MET PET and FDG PET, were prospectively enrolled in the study. The reference standard was established by histology or clinical and radiological follow-up. Images were interpreted by visual evaluation and semi-quantitative analysis using the lesion-to-normal white matter uptake ratio (L/WM ratio). Finally, 30 high-grade gliomas (HGG), 27 low-grade gliomas (LGG), 10 non-glioma tumors and 23 non-neoplastic lesions (NNL) were diagnosed. On visual evaluation, sensitivity and specificity for differentiating tumors from NNL were 62.7% (42/67) and 95.7% (22/23) for
AIM: To evaluate integrated 2-[F-18]-fluoro-2-deoxy-D-glucose (F-18-FDG) positron-emission tomography (PET)/magnetic resonance imaging (MRI), in comparison with the standard technique, integrated F-18-FDG-PET/computed tomography (CT), in preoperative staging of oesophageal or gastroesophageal junctional cancer.. MATERIALS AND METHODS: In the preoperative staging of 16 patients with oesophageal or gastroesophageal junctional cancer, F-18-FDG-PET/MRI was performed immediately following the clinically indicated F-18-FDG-PET/CT. MRI-sequences included T1-weighted fat-water separation (Dixons technique), T2-weighted, diffusion-weighted imaging (DWI), and gadolinium contrast-enhanced T1-weighted three-dimensional (3D) imaging. PET was performed with F-18-FDG. Two separate teams of radiologists conducted structured blinded readings of F-18-FDG-PET/MRI or F-18-FDG-PET/CT, which were then compared regarding tumour measurements and characteristics as well as assessment of inter-rater agreement (Cohens ...
PET/CT is generally not useful in CLL/SLL but can assist in directing nodal biopsy if Richters transformation is suspected. a. Initial staging: PET/CT scan considered useful in selected cases. b. Restaging after completion of treatment: imaging should be performed whenever there are clinical indications. If PET/CT is used in follow-up, progressive disease should be histologically documented (e.g., biopsy) to rule out transformation c. Non-gastric MALT lymphoma, marginal zone lymphoma (nodal, splenic), a. Initial staging: PET/CT scan considered useful in selected cases. a. Initial staging: PET/CT scan considered useful under certain a. Initial staging: PET/CT scan considered essential. b. Restaging after completion of treatment: repeat all positive studies. Biopsy of PET-positive sites is recommended before changing course of treatment. The optimum timing of PET/CT is unknown; however, waiting a minimum of 8 weeks to repeat PET/CT is suggested. False positives may occur due to ...
How to cleanse the iodine inside your body after a CT scan - Care guide for Positron Emission Tomography Scan (Aftercare Instructions). for Positron Emission Tomography Scan with a computed tomography (CT) scan.
The presence of lymph node metastases at the time of prostate cancer diagnosis has significant implications for treatment. According to current guidelines from the National Comprehensive Cancer Network, men with positive lymph nodes on initial staging imaging should be offered treatment with androgen deprivation (± abiraterone) along with consideration for external beam radiation therapy [1]. In contrast, men with clinically localised high‐ or very‐high‐risk prostate cancer have the option of undergoing radical prostatectomy. Unfortunately, currently available diagnostic imaging modalities (i.e. contrast‐enhanced CT and MRI) fall short in their ability to accurately identify lymph node metastases, which are often small and difficult to discern from other structures within the pelvis. Thus, there exists a conundrum: if we cannot accurately detect lymph node involvement, how can we appropriately manage it?. In this edition of the BJUI, Leeuwen et al. [2] report on the utility of molecular ...
The behavioral and psychophysiological alterations during recall in patients with trauma disorders often resemble phenomena that are seen in hypnosis. In studies of emotional recall as well as in neuroimaging studies of hypnotic processes similar brain structures are involved: thalamus, hippocampus, amygdala, medial prefrontal cortex, anterior cingulate cortex. This paper focuses on cross-correlations in traumatic recall and hypnotic responses and reviews correlations between the involvement of brain structures in traumatic recall and processes that are involved in hypnotic responsiveness ...
Purpose. To evaluate the prognostic value of metabolic parameters and bone marrow uptake (BMU) patterns on pretherapeutic 18-F-fluorodeoxyglucose (18F-FDG) positron emission tomography/computed tomography (PET/CT) in pediatric patients with neuroblastoma (NB).. Patients and methods. Forty-seven pediatric patients with newly diagnosed neuroblastoma who underwent 18F-FDG PET/CT were retrospectively reviewed. Clinicopathological factors and metabolic parameters including maximum standardized uptake value (SUVmax), metabolic tumor volume (MTV), total lesion glycolysis (TLG) and bone marrow uptake patterns on PET/CT were compared to predict recurrence-free survival (RFS) and overall survival (OS) by univariate and multivariate analysis.. Results. During the follow-up period, 27 (57.4%) patients experienced recurrence. MTV (P = 0.001), TLG (P = 0.004) and BMU patterns (P = 0.025) remained significant predictive factors for tumor recurrence, along with tumor size, histology, stage, lactate ...
Positron emission tomography (PET) allows for the measurement of cerebral blood flow (CBF; based on [15O]H2O) and cerebral metabolic rate of glucose utilization (CMRglu; based on [18 F]-2-fluoro-2-deoxy-d-glucose ([18 F]FDG)). By using kinetic modeling, quantitative CBF and CMRglu values can be obtained. However, hardware limitations led to the development of semiquantitive calculation schemes which are still widely used. In this paper, the analysis of CMRglu and CBF scans, acquired on a current state-of-the-art PET brain scanner, is presented. In particular, the correspondence between nonlinear as well as linearized methods for the determination of CBF and CMRglu is investigated. As a further step towards widespread clinical applicability, the use of an image-derived input function (IDIF) is investigated. Thirteen healthy male volunteers were included in this study. Each subject had one scanning session in the fasting state, consisting of a dynamic [15O]H2O scan and a dynamic [18 F]FDG PET scan,
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Simultaneous radio-chemotherapy in advanced non-small cell lung cancer. The study focusses on a randomised comparison of conventional radiotherapy plann
Purpose: To assess various volume based PET quantification metrics including: metabolic tumor volume (MTV) and total lesion glycolysis (TLG) with different thresholds as well as background activity based PET metrics (Background Subtracted Lesion activity (BSL) and Volume (BSV)) as prognostic markers for progression free and overall survival (PFS, OS) in early stage I and II non-small cell lung cancer (NSCLC) after resection. Patients and Methods: 133 patients received an adequate FDG PET/CT scan prior to surgery between January 2003 and December 2010. All PET activity metrics showed a skewed distribution and were log-transformed before calculating the Pearson correlation coefficients (PCC). Survival tree analysis was used to discriminate between high and low risk patients and to select the most important prognostic markers. Akaike information criterion (AIC) was used to compare two uni-variate models. Results: Within the study time 36 patients died from NSCLC and 26 patients from other causes. ...
Pietrini, Pietro and Guazzelli, Mario and Sarteschi, Pietro and Grady, Cheryl L. and Haxby, James V. and Swedo, Susan E. and Rapoport, Stanley I. and Schapiro, Mark B. Positron Emission Tomography (PET) as a tool to investigate cerebral glucose metabolism in neurologic and psychiatric disorders. Studies in dementia of the Alzheimer type and obsessive-compulsive disorder. In: Psychiatry and advanced technologies (ed. by L. Ravizza). Raven Press. ISBN 0781700035 (1993) Full text not available from this repository ...
Solid tumors are hypoxic with altered metabolism, resulting in secretion of acids into the extracellular matrix and lower relative pH, a feature associated with local invasion and metastasis. Therapeutic and diagnostic agents responsive to this microenvironment may improve tumor-specific delivery. Therefore, we pursued a general strategy whereby caged small-molecule drugs or imaging agents liberate their parent compounds in regions of low interstitial pH. In this manuscript, we present a new acid-labile prodrug method based on the glycosylamine linkage, and its application to a class of positron emission tomography (PET) imaging tracers, termed [(18)F]FDG amines. [(18)F]FDG amines operate via a proposed two-step mechanism, in which an acid-labile precursor decomposes to form the common radiotracer 2-deoxy-2-[(18)F]fluoro-d-glucose, which is subsequently accumulated by glucose avid cells. The rate of decomposition of [(18)F]FDG amines is tunable in a systematic fashion, tracking the pKa of the ...
Our group develops basic technologies and complete imaging systems that are able to track molecules and cells in living beings. We have been highly successful in developing Single Photon Emission Computed Tomography (SPECT) systems for small animals that provide images of molecular processes in organs and tumors with a world record spatial and temporal resolution (U-SPECT, see Fig. 1). Recently, we have developed a new scanner geometry that can not only image SPECT tracer molecules but is also able to visualize PET (Positron Emission Tomography) tracer molecules at very high resolutions at the same time (VECTor, see Fig. 2). This gives many unique opportunities to develop new pharmaceuticals and biomarkers for treatment and diagnosis of e.g. cancer, brain and cardiac disease. Our SPECT/PET scanner is also equipped with a CT in order to combine the functional information obtained with SPECT/PET with the anatomical information provided by the CT scan. We conduct research on all aspects of our ...
The concept of positron emission tomography (PET) imaging revolves around the measurement of a patients in vivo radiotracer distribution. The system detects pairs of gamma rays emitted indirectly by a positron-emitting radionuclide (tracer), which is introduced into the body via biologically active molecules. As such, PET imaging can be described via a line-integral model of acquisition [1]. PET data are collected as projections in sinograms or listmode format [2]. The raw data collected by a PET scanner are a list of coincidence events representing near-simultaneous detection, each coincidence event represents a line in space connecting the two detectors along which the positron emission occurred. While one can employ the inverse Radon transform to recover tomograms from acquired PET data, such an approach can be unstable, particularly when dealing with noise-contaminated data [3]. Therefore, the filtered back projection algorithm, which is a stabilized and discretized version of the inverse ...
What?. Positron emission tomography, also called PET imaging or a PET scan, is a diagnostic examination that uses signals emitted by radioactive tracers to construct images of the distribution of the tracers (positrons) in the human body. Positrons are tiny particles emitted from a radioactive substance administered to the patient. The subsequent images of the human body developed with this technique are used to evaluate a variety of diseases.. When? What are some common uses of the procedure?. PET scans are used most often to detect cancer and to examine the effects of cancer therapy by characterizing biochemical changes in the cancer. These scans can be performed on the whole body. PET scans of the heart can be used to determine blood flow to the heart muscle and help evaluate signs of coronary artery disease. PET scans of the heart can also be used to determine if areas of the heart that show decreased function are alive rather than scarred as a result of a prior heart attack, called a ...
Developed by renowned radiologists in each specialty, STATdx provides comprehensive decision support you can rely on - Positron Emission Tomography
Time-of-flight (TOF) positron-emission tomography (PET) has increasingly been adopted as an important quantitative imaging tool in basic and clinical applications. Improving image quality via advanced image reconstruction methods remains an area of active interest. In particular, it is of practical... Read more ...
Future Market Insights delivers key insights on the global Positron Emission Tomography scanners market in a new report titled, „Positron Emission Tomography (PET) Scanners Market: Global Industry Analysis and Opportunity Assessment, 2016-2026. In terms of revenue, the global Positron Emission Tomography (PET) scanners market is projected to register a healthy CAGR of 4.7% over the forecast period.. According to Future Market Insights, growing occurrences of chronic disorders and increasing penetration of PET machines is expected to drive overall growth of the global Positron Emission Tomography (PET) scanners market during the forecast period. Rising demand for effective diagnostic techniques across the globe and expanded applications for PET in the field of oncology are further expected to boost the growth of the global Positron Emission Tomography (PET) scanners market between 2016 and 2026. However, a short half-life and low supply of radiopharmaceuticals is likely to restrict market ...
The efficacy of preoperative positron emission tomography-computed tomography (PET-CT) for detection of lymph node metastasis in cervical and endometrial cancer : clinical and pathological factors influencing it(審査報告)The efficacy of preoperative positron emission tomography-computed tomography (PET-CT) for detection of lymph node metastasis in cervical and endometrial cancer : clinical and pathological factors influencing it(審査報告) ...
Objective: The objective of this study was to compare the accuracy of calculating the primary tumor volumes using a gradient-based method and fixed threshold methods on the standardized uptake value (SUV) maps and the net influx of FDG (Ki) maps from positron emission tomography-computed tomography (PET-CT) images. Materials and Methods: Newly diagnosed patients with head and neck cancer were recruited, and dynamic PET-CT scan and T2-weighted magnetic resonance imaging were performed. The maps of Ki and SUV were calculated from PET-CT images. The tumor volumes were calculated using a gradient-based method and a fixed threshold method at 40% of maximal SUV or maximal Ki. Four kinds of volumes, VOLKi-Gra (from the Ki maps using the gradient-based method), VOLKi-40% (from the Ki maps using the threshold of 40% maximal Ki), VOLSUV-Gra (from the SUV maps using the gradient-based method), and VOLSUV-40% (from the SUV maps using the threshold of 40% maximal SUV), were acquired and compared with VOLMRI ...
TY - JOUR. T1 - Diagnostic role of 18F-fluorodeoxyglucose positron emission tomography for follicular lymphoma with gastrointestinal involvement. AU - Iwamuro, Masaya. AU - Okada, Hiroyuki. AU - Takata, Katsuyoshi. AU - Shinagawa, Katsuji. AU - Fujiki, Shigeatsu. AU - Shiode, Junji. AU - Imagawa, Atsushi. AU - Araki, Masashi. AU - Morito, Toshiaki. AU - Nishimura, Mamoru. AU - Mizuno, Motowo. AU - Inaba, Tomoki. AU - Suzuki, Seiyu. AU - Kawai, Yoshinari. AU - Yoshino, Tadashi. AU - Kawahara, Yoshiro. AU - Takaki, Akinobu. AU - Yamamoto, Kazuhide. N1 - Copyright: Copyright 2021 Elsevier B.V., All rights reserved.. PY - 2012. Y1 - 2012. N2 - AIM: To investigate the capacity for 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography (PET) to evaluate patients with gastrointestinal lesions of follicular lymphoma. METHODS: This retrospective case series consisted of 41 patients with follicular lymphoma and gastrointestinal involvement who underwent 18F-FDG-PET and endoscopic evaluations at ten ...
Ly et al: CAA Predisposes to rt-PA Related Hhemorrhage Cerebral b-Amyloid Detected by Pittsburgh Compound B Positron Emission Topography Predisposes to Recombinant Tissue Plasminogen Activator-Related Hemorrhage John V. Ly,1 Christopher C. Rowe,2 Victor L. Villemagne,2 Jorge A. Zavala,1 Henry Ma,1 Graeme OKeefe,2 Sylvia J. Gong,2 Rico Gunawan,1 Leonid Churilov,1 Tim Saunder,2 Uwe Ackerman,2 Henri Tochon-Danguy,2 and Geoffrey A. Donnan1,3 Cerebral amyloid angiopathy (CAA) may be an important predisposing factor for the hemorrhagic complications of recombinant tissue-type plasminogen activator (rt-PA) therapy. We studied patients treated within 3 hours of onset of ischemic stroke with rt-PA using positron emission tomography to compare Pittsburgh compound B (PiB) (a cerebral b-amyloid ligand) retention in those with and without parenchymal hemorrhage (PH) and normal controls. Neocortical PiB retention was higher among patients with PH compared with patients without PH and normal controls, ...
Deep learning (DL)-based image quality improvement is a novel technique based on convolutional neural networks. The aim of this study was to compare the clinical value of 18F-fluorodeoxyglucose positron emission tomography (18F-FDG PET) images obtained with the DL method with those obtained using a Gaussian filter. Fifty patients with a mean age of 64.4 (range, 19-88) years who underwent 18F-FDG PET/CT between April 2019 and May 2019 were included in the study. PET images were obtained with the DL method in addition to conventional images reconstructed with three-dimensional time of flight-ordered subset expectation maximization and filtered with a Gaussian filter as a baseline for comparison. The reconstructed images were reviewed by two nuclear medicine physicians and scored from 1 (poor) to 5 (excellent) for tumor delineation, overall image quality, and image noise. For the semi-quantitative analysis, standardized uptake values in tumors and healthy tissues were compared between images obtained using
BACKGROUND: Inflammation plays a key role in progression and destabilization of atherosclerotic plaque. [18F]-fluorodeoxyglucose positron emission tomography (18FDG-PET) is a promising tool for visualizing inflammation of atherosclerotic plaque. Anti-inflammatory action is one of the pleiotropic effects of statins.. OBJECTIVE: We investigated whether simvastatin attenuates plaque inflammation by using 18FDG-PET co-registered with computed tomography.. METHODS and RESULTS: Forty-three consecutive subjects, who underwent 18FDG-PET for cancer screening and had 18FDG uptakes in the thoracic aorta and/or the carotid arteries, were randomized to either statin group receiving simvastatin (n=21) or diet group receiving dietary managements (n=22). The maximum standardized uptake values (SUVs) were measured in individual plaques, and were averaged for analysis of the subject-wise results. The responses were assessed after 3-month treatments. PET revealed 117 and 123 18FDG-positive plaques in the statin ...
F18-fluorodeoxyglucose positron emission tomography (FDG-PET), commonly combined with computed tomography (CT), is widely used in the initial evaluation and response assessment of patients with Hodgkins lymphoma (HL). Its sensitivity for nodal and extranodal sites of disease can add to the staging information obtained with CT alone,1 and PET is valuable in the response assessment at the end of front-line therapy because it can distinguish active disease from fibrosis in residual masses. In fact, the goal of front-line therapy is now a PET-negative complete remission (CR).2 Interim PET scan, performed during the initial course of therapy, may also have prognostic significance,3 and treatment adapted to interim PET results is under investigation in ongoing clinical trials. The role of PET in the response assessment and management of relapsed and refractory HL is less well established than in the front-line setting. Up to 30 % of patients with HL will fail to respond to, or will relapse after, ...
A proportion of patients with pancreatic cancer never develop metastatic disease. We evaluated a role for (18)F-fluorodeoxyglucose positron emission tomography (FDG-PET) in identifying a subset of patients with locally advanced pancreatic cancer (LAPC) who never develop metastatic disease and only experience local disease and may therefore benefit from local treatment intensification.
PubMedID: 23509326 | Fasting 2-deoxy-2-[18F]fluoro-D-glucose positron emission tomography to detect metabolic changes in pulmonary arterial hypertension hearts over 1 year. | Annals of the American Thoracic Society | 2/1/2013
It has been well established that hepatocellular carcinomas (HCCs) accumulate [[sup 18]F]fluorodeoxy-glucose (FDG) to varying degrees; this is thought to be due to differing amounts of FDG-6-phosphatase activity. The purpose of this study was to evaluate the impact of FDG imaging on the management of patients diagnosed with hepatocellular carcinoma. We conducted a retrospective review of the clinical data of 91 consecutive patients diagnosed with HCC who underwent FDG-positron emission tomography (PET) imaging between August 1993 and March 2001. The patients were divided into two groups. In Group one 67 of 91 (74%) patients were evaluated for proven but untreated hepatic lesions using PET. In Group two the remaining 24 patients (26%) were referred for evaluation of HCC recurrence but did not have prior PET. The FDG images were acquired with two dedicated PET tomographs [Siemens ECAT 933, CTI (Knoxville, TN) and GE Advance, General Electric Medical Systems (Milwaukee, WI)] one hour after the ...
BACKGROUND: Positron emission tomography combined with computed tomography (PET-CT) is increasingly being used in the staging of oesophageal cancer. Some recent reports suggest it may be used to predict survival. None of these studies, however, reported on the prognostic value of PET-CT performed before neoadjuvant chemotherapy and surgery. The aim of this study was to determine whether pretreatment PET-CT could predict survival. METHODS: Consecutive patients with oesophageal adenocarcinoma who underwent PET-CT before neoadjuvant chemotherapy and resection were included. Maximum standardized uptake value (SUV(max)), fluorodeoxyglucose (FDG)-avid tumour length and the presence of FDG-avid local lymph nodes were determined for all patients. Kaplan-Meier survival analysis was performed and multivariable analysis used to identify independent prognostic factors. RESULTS: A total of 121 patients were included (mean age 63 years, 97 men) of whom 103 underwent surgical resection. On an intention-to-treat basis,
PURPOSE To assess the value of (18)F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) in patients with nasopharyngeal carcinoma as compared with PET and conventional imaging (CI) alone, and to assess the impact of PET/CT on further clinical management. METHODS AND MATERIALS Thirty-three patients with nasopharyngeal carcinoma had 45 PET/CT examinations. The study was a retrospective analysis. Changes in patient care resulting from the PET/CT studies were recorded. RESULTS Positron emission tomography/computed tomography had sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of 92%, 90%, 90%, 90%, and 91%, respectively, as compared with 92%, 65%, 76%, 86%, and 80% for PET and 92%, 15%, 60%, 60%, and 60% for CI. Imaging with PET/CT altered further management of 19 patients (57%). Imaging with PET/CT eliminated the need for previously planned diagnostic procedures in 11 patients, induced a change in the planned therapeutic
Although 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography (PET) is a delicate modality for detecting a malignant lesion, increased 18F-FDG uptake is also seen in infected or inflammatory processes. nodes with intense 18F-FDG uptake (maximum SUV of 8.8) are seen in the right axilla (in a and c), which were diagnosed with tuberculous lymphadenitis. Moreover, a lymph node with intense 18F-FDG uptake (optimum SUV of 5.0) sometimes appears in the proper lower paratracheal section of the mediastinum (in a and c) Subsequently, she underwent best mastectomy with best axillary lymph node dissection. Histopathological study of the right breasts lesion demonstrated invasive ductal breasts carcinoma without lymphatic or vascular invasion. All 36 dissected lymph nodes demonstrated granulomatous lymphadenitis with caseation necrosis no involvement of malignancy. Special spots for acid-fast bacilli had been detrimental for the axillary lymph nodes; nevertheless, polymerase chain response (PCR) ...
Looking for online definition of Positron Emission Tomography, Pelvis in the Medical Dictionary? Positron Emission Tomography, Pelvis explanation free. What is Positron Emission Tomography, Pelvis? Meaning of Positron Emission Tomography, Pelvis medical term. What does Positron Emission Tomography, Pelvis mean?
Fluorine-18 fluorodeoxyglucose (FDG) positron emission tomography (PET) has been recommended as a complementary tool for the staging of various malignancies, including malignant lymphoma. PET...
Background/Purpose: The disease activity score based on 28 joints (DAS-28) might not be sufficient to assess remission in rheumatoid arthritis (RA). Several studies have shown that patients in remission according to DAS-28 still evidence synovitis by Ultrasound (US) and Magnetic Resonance Imaging (MRI). Those patients could eventually develop irreversible joint damage. Although 18F-Fluorodeoxyglucose Positron Emission Computer Tomography (18F-FDG PET/CT) is known to be correlated with DAS-28 in patients with active RA, its role in assessing remission has not yet been evaluated.. Methods: A cross-sectional study was performed on 63 RA patients. A total of 1764 joints was assessed. Clinical assessment (DAS-28), 18F-FDG PET/CT and US were performed the same day. Patients were classified in 3 groups according to their disease status : 22 (35%) were in remission (DAS-28 , 2.6), 31 (49%) had a low or moderate disease activity (2.6 , DAS-28 ≤ 5.1) and 10 (16%) had a severe disease activity (DAS 28 , ...
Video articles in JoVE about positron emission tomography include Human Brown Adipose Tissue Depots Automatically Segmented by Positron Emission Tomography/Computed Tomography and Registered Magnetic Resonance Images, Non-invasive Imaging and Analysis of Cerebral Ischemia in Living Rats Using Positron Emission Tomography with 18F-FDG, A Basic Positron Emission Tomography System Constructed to Locate a Radioactive Source in a Bi-dimensional Space, Quantification of Atherosclerotic Plaque Activity and Vascular Inflammation using [18-F] Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography (FDG-PET/CT), Radionuclide-fluorescence Reporter Gene Imaging to Track Tumor Progression in Rodent Tumor Models, The Bioconjugation and Radiosynthesis of 89Zr-DFO-labeled Antibodies, Creating Dynamic Images of Short-lived Dopamine Fluctuations with lp-ntPET: Dopamine Movies of Cigarette Smoking, Murine Lymphocyte Labeling by 64Cu-Antibody Receptor Targeting for In Vivo Cell Trafficking by
Purpose: To investigate the prognostic role of metabolic response by the use of serial sets of positron emission tomography/computed tomography (PET/CT) in patients with cervical cancer who were treated with concurrent chemoradiation therapy (CCRT). Methods and Materials: A total of 60 patients who were treated with CCRT between February 2009 and December 2010 were analyzed. Three sequential PET/CT images were acquired for each patient: pre-CCRT, during-CCRT at 4 weeks of CCRT, and 1 month post-CCRT PET/CT. Metabolic responses were assessed qualitatively. The percentage changes in the maximum values of standardized uptake value (ΔSUV{sub max}%) from the PET/CT images acquired pre-CCRT and during-CCRT were calculated. Receiver operating characteristic (ROC) curve analysis was performed to evaluate whether ΔSUV{sub max}% could predict complete response (CR) on the post-CCRT PET/CT and to identify the best cutoff value. Prognostic factors of progression-free survival (PFS) were analyzed. Results: ...
Ahmad Mirza, MD, Ian Welch, Simon Galloway. The University Hospital of South Manchester, Manchester, United Kingdon. INTRODUCTION: The staging laparoscopy has been used in management of gastrointestinal cancers. The aim of this study was to evaluate the role of staging laparoscopy, in comparison with computed tomography (CT) and Fluorodeoxyglucose positron emission tomography (FDG-PET) imaging in staging patients with gastroesophageal junction (GOJ) and gastric cancer.. METHODS: The data were collected for patients between 1996 and 2013 for patients undergoing investigation and treatment for GOJ and gastric cancer at a single institute. The pre-operative data (staging data), intra-operative details, post-operative course and outpatient follow-up were analysed for individual cases.. RESULTS: Staging laparoscopy altered management plan in 54 (14%) of 387 patients. Patients with negative staging CT scan and negative FDG-PET, 7% (Type I, II and III GOJ) were identified with pathological ...
Positron Emission Tomography Scanners Market: Global Demand, Growth Analysis & Opportunity Outlook 2023. The global positron emission tomography scanners market is segmented into applications such as oncology, cardiology and neurology. Among these segments, with 85% market share in overall positron emission tomography scanners market, oncology occupied the biggest share in terms of revenue in 2015 and it is expected to garner at a notable CAGR of 4.3% during the forecast period. Further, the growth of this segment is attributed to increasing number of population affected with cancer. Moreover, favorable government initiates along with adoption of technological advanced devices to diagnose and determine the severity of diseases such as cancer and others is also believed to foster the growth of positron emission tomography scanners market. Global positron emission tomography scanners market is anticipated to account for a notable CAGR of 5.2% over the forecast period i.e. 2015-2023. Moreover, the ...
Positron Emission Tomography Scanners Market: Global Demand, Growth Analysis & Opportunity Outlook 2023. The global positron emission tomography scanners market is segmented into applications such as oncology, cardiology and neurology. Among these segments, with 85% market share in overall positron emission tomography scanners market, oncology occupied the biggest share in terms of revenue in 2015 and it is expected to garner at a notable CAGR of 4.3% during the forecast period. Further, the growth of this segment is attributed to increasing number of population affected with cancer. Moreover, favorable government initiates along with adoption of technological advanced devices to diagnose and determine the severity of diseases such as cancer and others is also believed to foster the growth of positron emission tomography scanners market. Global positron emission tomography scanners market is anticipated to account for a notable CAGR of 5.2% over the forecast period i.e. 2015-2023. Moreover, the ...
Despite the growing use of [18F]-FDG PET imaging in oncology (9, 10), limited data exist regarding its use in monitoring treatment response and predicting survival in advanced TETs (11, 19-31). With a few exceptions (25, 27, 28, 30), most studies in this area have been retrospective, involving small sample sizes and inconsistent measures of [18F]-FDG uptake. Furthermore, the majority of the studies have an overrepresentation of thymoma compared with thymic carcinoma. There is limited information on its role in monitoring treatment response and as a predictor of survival (20, 23), and we are not aware of prospective systematic studies addressing these questions.. As a retrospective analysis of prospectively collected data, this study shows that in patients with advanced or recurrent TETs: (i) effective treatment with chemotherapy or targeted therapy causes rapid reduction in [18F]-FDG uptake, (ii) early metabolic response predicts eventual RECIST response and is associated with improved PFS, and ...
Sigma-Aldrich offers abstracts and full-text articles by [Sung Gwe Ahn, Jong Tae Park, Hak Min Lee, Hak Woo Lee, Tae Joo Jeon, Kyunghwa Han, Seung Ah Lee, Seung Myung Dong, Young Hoon Ryu, Eun Ju Son, Joon Jeong].
The present study, discussed a rare case of a 50‑year‑old woman who was treated for malignant melanoma and underwent 18F‑fluorodeoxyglucose (FDG) positron emission tomography (PET)/computed tomography (CT) examination for evaluation of disease. 18F‑FDG‑PET/CT examination was performed from the top of the head down to the knee using a Gemini TF PET/CT scanner 60 min following intravenous injection of radiotracer with mean activity of 364±75 MBq. Previous performed laboratory test and clinical examination was irrelevant. By abdominal ultrasound no abnormalities in abdominal organs beside the liver cyst were found. The 18F‑FDG PET/CT exam showed an increased glucose metabolism in the anterior pole of the spleen, which was considered as melanoma metastasis. Splenectomy was performed and histopathology examination tuberculous lesion in the spleen was revealed. Histopathology examination showed epithelioid granuloma and in correlation with the patients history allowed to establish ...
We audited whether 18F-Fluorodeoxyglucose positron emission tomography-computed tomography (18FDG PET-CT) imaging could discriminate between different diagnoses in HIV-infected patients presenting with lymphadenopathy, with or without fever and/or splenomegaly. Maximum standardised uptake (SUVmax) values were similar in lymphoma and mycobacterial and fungal infections and were lower but similar in those with human herpesvirus (HHV) 8-associated disease and HIV-associated reactive lymphadenopathy. Nodal 18FDG avidity, with SUVmax ≥10, excluded diagnoses of HHV 8-associated disease and miscellaneous conditions, and HIV-associated reactive lymphadenopathy was additionally excluded in those who had undetectable plasma HIV viral loads ...
Background and purpose: To analyze the recurrence pattern in relation to target volumes and 18F-fluorodeoxyglucose (FDG) uptake on positron emission tomography in head and neck squamous cell carcinoma (HNSCC) patients treated with definitive chemoradiation. Material and methods: 520 patients received radiotherapy for HNSCC from 2005 to 2009. Among 100 patients achieving complete clinical response and a later recurrence, 39 patients with 48 loco-regional failures had a recurrence CT scan before any salvage therapy. The estimated point of origin of each recurrence was transferred to the planning CT by deformable image co-registration. The recurrence position was then related to the delineated target volumes and iso-SUV-contours relative to the maximum standard uptake value (SUV). We defined the recurrence density as the total number of recurrences in a sub-volume divided by the sum of that volume for all patients. Results: 54% (95% CI 37-69%) of recurrences originated inside the FDG-positive ...
INTRODUCTION: The prevalence and detailed biomarkers characteristic of rapidly progressive Alzheimers disease (rpAD) remain incompletely understood.METHODS: A total of 312 mild AD patients from the Alzheimers Disease Neuroimaging Initiative database were chosen and dichotomized into rpAD and non-rpAD groups. We performed the prevalence and comprehensive biomarker evaluation.RESULTS: The prevalence of rpAD was 17.6% in mild AD. Compared with non-rpAD, there were no differences in APOE ε4/ε4, APOE ε3/ε4, and APOE ε2/ε4 genotype distribution, cerebrospinal fluid tau, phosphorylated tau (p-tau), amyloid-β, hippocampus volume, and amyloid deposition in rpAD. Yet, a lower p-tau/tau ratio was observed in rpAD (P = .04). rpAD showed region-specific hypometabolism ([18F]fluorodeoxyglucose-positron emission tomography [FDG-PET]) (P = .001). Receiver-operating characteristic analysis of FDG-PET demonstrated that left angular and left temporal cortices were the regions with higher area under the ...
In Parkinsons disease patients with cognitive deterioration, regional cortical hypometabolism has been observed with [18F]fluorodeoxyglucose-positron emission tomography (FDG-PET). Our aim was to develop a robust method to subsume the overall degree of metabolic deterioration in Parkinsons disease by means of a single index and to investigate which of the clinical features correlates best with hypometabolism. Twenty-two Parkinsons patients (10 demented) and seven controls underwent FDG-PET. A metabolic index (mean relative uptake in typically affected regions) was calculated for each patient and compared with scores for cognition [Minimental State Examination (MMSE)], motor performance [Unified Parkinsons Disease Rating Scale (UPDRS III) and behavior (Neuropsychiatric Inventory). In stepwise linear regression analysis, MMSE (P , 0.001) score showed the only significant effect. Estimated sensitivity and specificity for DSM-IV diagnosis of dementia were high for the metabolic index (MI), with ...
PubMed Central Canada (PMC Canada) provides free access to a stable and permanent online digital archive of full-text, peer-reviewed health and life sciences research publications. It builds on PubMed Central (PMC), the U.S. National Institutes of Health (NIH) free digital archive of biomedical and life sciences journal literature and is a member of the broader PMC International (PMCI) network of e-repositories.
BACKGROUND: The purpose of this study was to assess the role of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and (18)F-fluorodeoxyglucose positron emission tomography computed tomography (FDG-PET/CT) for evaluation of response to chemotherapy and bevacizumab and for prediction of progression-free survival (PFS) in patients with metastatic colorectal cancer (mCRC) with potentially resectable liver lesions. METHODS: A total of 19 mCRC patients were treated with FOLFOX/FOLFIRI and bevacizumab followed by surgery. Dynamic contrast-enhanced magnetic resonance imaging and FDG-PET/CT were performed before treatment and after cycle 5. PET results were quantified by calculating maximum standardised uptake value (SUV(max)) whereas area under the enhancement curve (AUC), initial AUC (iAUC) and the endothelial transfer constant (K(trans)) were used to quantify DCE-MRI. Pathological analysis of the resection specimen was performed, including measurement of microvessel density (MVD) and ...
PubMed Central Canada (PMC Canada) provides free access to a stable and permanent online digital archive of full-text, peer-reviewed health and life sciences research publications. It builds on PubMed Central (PMC), the U.S. National Institutes of Health (NIH) free digital archive of biomedical and life sciences journal literature and is a member of the broader PMC International (PMCI) network of e-repositories.
Positron emission tomography (PET) is a specialized radiology procedure used to examine various body tissues to identify certain conditions. PET may also be used to follow the progress of the treatment of certain conditions. While PET is most commonly used in the fields of neurology, oncology, and cardiology, applications in other fields are currently being studied.. PET is a type of nuclear medicine procedure. This means that a tiny amount of a radioactive substance, called a radionuclide (radiopharmaceutical or radioactive tracer), is used during the procedure to assist in the examination of the tissue under study. Specifically, PET studies evaluate the metabolism of a particular organ or tissue, so that information about the physiology (functionality) and anatomy (structure) of the organ or tissue is evaluated, as well as its biochemical properties. Thus, PET may detect biochemical changes in an organ or tissue that can identify the onset of a disease process before anatomical changes related ...
Purpose. The main objective of this study was to evaluate the prognostic value of volumetric and metabolic information derivied from F-18 fluorodeoxyglucose positron emission tomography (18F-FDG PET) in combination with computed tomography (CT) prior to liver transplantation (LT) in patients with nonresectable colorectal liver metastases (CLM). Due to scarcity of liver grafts, prognostic information enabling selection of candidates who will gain the highest survival after LT is of vital importance. 18F-FDG PET/CT was a part of the preoperative study protocol. Patients without evidence of extrahepatic malignant disease on 18F-FDG PET/CT who also fulfilled all the other inclusion criteria underwent LT.. Methods. The preoperative 18F-FDG PET/CT examinations of all patients included in the SECA (secondary cancer) study were retrospectively assessed. Maximum, mean and peak standardized uptake values (SUVmax, SUVmean and SUVpeak), tumor to background (T/B) ratio, metabolic tumor volume (MTV) and total ...
Authors: Sally F Barrington, N George Mikhaeel, Lale Kostakoglu, Michel Meignan, Martin Hutchings, Stefan Mueller, Lawrence H Schwartz, Emanuele Zucca, Richard I Fisher, Judith Trotman, Otto S Hoekstra, Rodney J Hicks, Michael J ODoherty, Roland Hustinx, Alberto Biggi, Bruce D Cheson
A study in this months Disease of the Colon and Rectum reports on the impact of 18-fluorodeoxyglucose positron emission tomography-computed tomography on rectal cancer management.. ...
Background The relationship between biomechanical properties and biological activities in aortic aneurysms was investigated with finite element simulations and F-18-fluoro-deoxy-glucose (F-18-FDG) positron emission tomography. Methods and Results The study included 53 patients (45 men) with aortic aneurysms, 47 infrarenal (abdominal aortic) and 6 thoracic (thoracic aortic), who had 1 F-18-FDG positron emission tomography/computed tomography. During a 30-month period, more clinical events occurred in patients with increased F-18-FDG uptake on their last examination than in those without (5 of 18 [28%] versus 2 of 35 [6%]; P=0.03). Wall stress and stress/strength index computed by finite element simulations and F-18-FDG uptake were evaluated in a total of 68 examinations. Twenty-five (38%) examinations demonstrated 1 aneurysm wall area of increased F-18-FDG uptake. The mean number of these areas per examination was 1.6 (18 of 11) in thoracic aortic aneurysms versus 0.25 (14 of 57) in abdominal ...
The complexities of cancer, and cachexia induced by cancer, dictate the necessity of studying this disease in the context of its microenvironment as well as in the context of interactions between the tumor and the body, i.e., the macroenvironment. In the present study, we are applying molecular and functional imaging to understand cancer cachexia and develop clinically translatable indices for early detection of this condition. As models, we are using cachectic (MAC16) and non-cachectic (MAC13) murine colon adenocarcinoma cells. MAC16 tumors induce extensive weight loss in tumor-bearing animals, whereas MAC13 tumors, although histologically similar, do not induce weight loss. By using in vivo 1H MRSI, we detected a high level of total choline in cachectic tumors compared to non-cachectic ones but no differences in lactate levels in tumor extracts. We then performed [18F]fluorodeoxyglucose positron emission tomography studies and observed a significant increase in glucose uptake in the ...
F-fluorodeoxyglucose positron emission tomography and computed tomography in anaplastic thyroid cancer. Poisson, Thomas; Deandreis, Désirée; Leboulleux, Sophie; Bidault, François; Bonniaud, Guillaume; Baillot, Sylvain; Aupérin, Anne; Ghuzlan, Abir; Travagli, Jean-Paul; Lumbroso, Jean; Baudin, Eric; Schlumberger, Martin // European Journal of Nuclear Medicine & Molecular Imaging;Dec2010, Vol. 37 Issue 12, p2277 Purpose: Our aim was to evaluate in anaplastic thyroid carcinoma (ATC) patients the value of F-FDG PET/CT compared with total body computed tomography (CT) using intravenous contrast material for initial staging, prognostic assessment, therapeutic monitoring and follow-up. Methods: Twenty... ...
BACKGROUND: This study investigates whether a histone deacetylase subtype 6 (HDAC6) inhibitor could be used in the treatment of solid tumours.. METHODS: We evaluated the effect of a novel inhibitor, C1A, on HDAC6 biochemical activity and cell growth. We further examined potential of early noninvasive imaging of cell proliferation by [(18)F]fluorothymidine positron emission tomography ([(18)F]FLT-PET) to detect therapy response.. RESULTS: C1A induced sustained acetylation of HDAC6 substrates, α-tubulin and HSP90, compared with current clinically approved HDAC inhibitor SAHA. C1A induced apoptosis and inhibited proliferation of a panel of human tumour cell lines from different origins in the low micromolar range. Systemic administration of the drug inhibited the growth of colon tumours in vivo by 78%. The drug showed restricted activity on gene expression with ,0.065% of genes modulated during 24 h of treatment. C1A treatment reduced tumour [(18)F]FLT uptake by 1.7-fold at 48 h, suggesting that ...
Abstract:. Gestational or pregnancy‑associated breast cancer is defined as breast cancer that is diagnosed during pregnancy, in the first post‑partum year or any time during lactation. We report a rare imaging finding of breast cancer seen on fluorodeoxyglucose‑positron emission tomography/computed tomography (FDG PET/CT) study in a 32‑year‑old lactating woman. The FDG PET/CT study demonstrated uptake in the soft tissue lesion noted in the right breast corresponding to the primary lesion and multiple nodes in the bilateral axilla, right supraclavicular and mediastinum. In addition, there was FDG tracer uptake in both the breast parenchyma related to breast feeding. This case illustrates the first case of breast cancer in a lactating woman described in FDG PET/CT.. ...
PURPOSE: To assess prospectively the value of fluor-18-deoxyglucose (FDG) positron emission tomography (PET), in addition to conventional diagnostic methods (CDM), as a staging modality in candidates for resection of colorectal liver metastases. PATIENTS AND METHODS: In 51 patients analyzed for resection of colorectal liver metastases, clinical management decisions were recorded after a complete work-up with CDM. Afterward, FDG-PET scans were performed and any change of clinical management according to FDG-PET results was carefully documented. Discordances between FDG-PET and CDM results were identified and related to the final diagnosis by histopathology, intraoperative findings, and follow-up. RESULTS: In 10 (20%) out of 51 patients, clinical management decisions based on CDM were changed after FDG-PET findings were known. FDG-PET detected unresectable pulmonary (n = 5) and hepatic metastases (n = 1) and ruled out extrahepatic (n = 2) and hepatic disease (n = 2). Due to FDG-PET, eight patients ...
AbstractNo data exist whether statins have robust anti-inflammatory effects of atherosclerotic plaques primarily during the early treatment period or continuously throughout use. This prospective three time point18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) study of the carotid artery assessed anti-inflammatory effects of statin during the early treatment...
2010). "Clinical value of 18F-fluorodihydroxyphenylalanine positron emission tomography/computed tomography (18F-DOPA PET/CT) ... Positron-emission tomography (PET)[1] is a nuclear medicine functional imaging technique that is used to observe metabolic ... Bailey, D.L; D.W. Townsend; P.E. Valk; M.N. Maisey (2005). Positron-Emission Tomography: Basic Sciences. Secaucus, NJ: Springer ... Vardi, Y.; L. A. Shepp; L. Kaufman (1985). "A statistical model for positron emission tomography". Journal of the American ...
Positron emission tomography (PET) is a widely used imaging technique in the field of nuclear medicine. With applications in ... This process has many applications especially with the use of positron emission tomography (PET) as the aforementioned low ... doi:10.1016/S0022-1139(00)80525-4. "Positron Emission Tomography". Knochel, A., Zwernemann, O. (1991). "Aromatic n.c.a. ... This is due to its 97% positron emission and relatively long 109.8 min half-life. The half-life allows for a long enough time ...
ISBN 978-0-7619-2760-0. Raichle M (1999). "Positron Emission Tomography". The MIT Encyclopedia of the Cognitive Sciences. MIT ... By the 1990s, psychologists began using positron emission tomography (PET) and later functional magnetic resonance imaging ( ...
"Positron Emission Tomography (PET)". Imaging Facilities. University of Manchester. Retrieved 18 September 2019. "Magnetic ... is a purpose built facility designed to exploit the potential for Positron Emission Tomography (PET) in oncology, neuroscience ...
Positron Emission Tomography Center; Breast Center; Baby-Friendly Center; Hemodialysis Center; Respiratory Care Center; Pain ...
The Fly Algorithm has been successfully applied in single-photon emission computed tomography and positron emission tomography ... Single-photon emission computed tomography (SPECT) reconstruction Positron emission tomography (PET) reconstruction Digital art ... Positron Emission Tomography reconstruction. Cooperative coevolution is a broad class of evolutionary algorithms where a ... Another application field of the Fly Algorithm is reconstruction for emission Tomography in nuclear medicine. ...
A positron emission tomography study". Brain. 115 (1): 15-36. doi:10.1093/brain/115.1.15. PMID 1559150. Kanwisher, N.; ...
Using positron emission tomography (PET), Sergent found that there were different patterns of activation in response to the two ... A positron emission tomography study". Brain. 115 (1): 15-36. doi:10.1093/brain/115.1.15. PMID 1559150. Sergent, J.; Signoret, ... Sergent, J; Zuck, E; Lévesque, M; MacDonald, B (1992). "Positron emission tomography study of letter and object processing : ... Sergent, J (1992). "Functional neuroanatomy of face and object processing : A positron emission tomography study". Brain. 115 ( ...
A positron emission tomography study". Brain. 115 (1): 15-36. doi:10.1093/brain/115.1.15. PMID 1559150. Weiner, Kevin S.; Grill ... The FFA was discovered and continues to be investigated in humans using positron emission tomography (PET) and functional ...
Bailey, DL (2005). Positron Emission Tomography: Basic Sciences. Elsevier. doi:10.1007/b136169. ISBN 978-1-84628-007-8. OCLC ...
Used in positron emission tomography. One of the few stable odd-odd nuclei Nitrogen-13 and oxygen-15 are produced in the ... Two sources of nitrogen-15 are the positron emission of oxygen-15 and the beta decay of carbon-15. Nitrogen-15 presents one of ... emitting a positron. The positron quickly annihilates with an electron, producing two gamma rays of about 511 keV. After a ...
See also positron emission tomography. 3H or tritium is a beta emitter. 111In is a gamma emitter. Iodine-123 (I-123) is a gamma ... 13N is a positron emitter. 15O is a positron emitter. 32P is a beta emitter. 223Ra is an alpha emitter. 82Rb is a positron and ... 11C is a positron emitter. 14C is a beta emitter. 51Cr is a gamma emitter. 57Co is a gamma emitter. 58Co is a gamma emitter. ... 22Na is a positron and gamma emitter. 24Na is a beta and gamma emitter. 89Sr is a beta emitter. Technetium-99m is a gamma ...
Bailey, D.L; D.W. Townsend; P.E. Valk; M.N. Maisey (2005). Positron Emission Tomography: Basic Sciences. Secaucus, NJ: Springer ... PET radiotracer is a type of radioligand that is used for the diagnostic purposes via positron emission tomography imaging ... Medicinal radiocompounds List of PET radiotracers Positron emission tomography Medicinal radiochemistry Radioligand Wadsak ... The system detects pairs of gamma rays emitted indirectly by a positron-emitting radionuclide (tracer), which is introduced ...
A positron emission tomography study". Brain. 115 (1): 15-36. doi:10.1093/brain/115.1.15. PMID 1559150. Gorno-Tempini, M. L.; ...
... and positron emission tomography known as PET scans. Positron emission tomography involves injecting a short-lived radioactive ... Bailey, D.L; Townsend, D.W.; Valk, P.E.; Maisey, M.N. (2003). Positron Emission Tomography: Basic Sciences. Secaucus, NJ: ... When the radioisotope decays, it emits positrons which are detected by the machine sensor. The isotope is chemically ...
A positron emission tomography study". Experimental Brain Research. 139 (3): 278-286. doi:10.1007/s002210100751. PMID 11545466 ...
Positron emission tomographyEdit. Positron emission tomography (PET) and brain positron emission tomography, measure emissions ... the development of radioligands allowed single photon emission computed tomography (SPECT) and positron emission tomography ( ... Single-photon emission computed tomographyEdit. Single-photon emission computed tomography (SPECT) is similar to PET and uses ... Positron Emission Tomography (PET)Edit. In PET scans, imaging does not rely on intrinsic biological processes, but relies on a ...
Positron emission tomography camerasEdit. The isotope 89Zr has been applied to the tracking and quantification of molecular ... antibodies with positron emission tomography (PET) cameras (a method called "immuno-PET"). Immuno-PET has reached a maturity of ... Radioactive isotopes at or above mass number 93 decay by electron emission, whereas those at or below 89 decay by positron ... is also known and S-type stars are recognised by detection of its emission lines in the visual spectrum.[26] ...
Positron emission tomography (PET)Edit. Positron emission tomography (PET), a nuclear medicine imaging methodology for positron ... Single photon emission computed tomography (SPECT)Edit. Single photon emission computed tomography (SPECT), a nuclear medicine ... Computed tomography (CT)Edit. Coronary Computed Tomography Angiography (CCTA)Edit. Image of contrast enhanced dual-source ... Computed tomography angiography (CTA), an imaging methodology using a ring-shaped machine with an X-Ray source spinning around ...
... with positron emission tomography (PET). In 2005, he published a research article that demonstrates that the functional ... "Positron-emission tomography with [18F]fluorodeoxyglucose". Journal of Cancer Research and Clinical Oncology. 126 (10): 549-559 ...
Positron emission tomography scans (i.e. PET scans) and positron emission tomography-computed tomography scans (i.e. PET-CT ... Whole body computed tomography scans (i.e. CT scans) frequently find enlarged mesenteric lymph nodes (i.e. lymph nodes attached ...
1999: Atlas of Clinical Positron Emission Tomography: By R. Wahl, S. Barrington, M. Maisey. CRC Press. 2005: Atlas of Clinical ... Sally Barrington is a professor of positron emission tomography (PET) Imaging and National Institute of Health Research (NIHR) ... Barrington, Sally (2005-11-25). Atlas of Clinical Positron Emission Tomography. CRC Press. doi:10.1201/b13518. ISBN 978-0-429- ... 2005). Atlas of Clinical Positron Emission Tomography 2nd Edition. Hodder Education. OCLC 746577890. Iagaru, Andrei, Sonstige. ...
Positron emission tomography was invented. 1987. The first successful heart-lung transplant. 1995. Use of adult stem cells in ...
2003) using Positron Emission Tomography (PET). The PET found that thinking about past events increased blood flow to the ... used advanced magnetic resonance and SPECT (single photon emission computed tomography) imaging techniques on the same sample ...
Hong H, Zhang Y, Sun J, Cai W (June 2010). "Positron emission tomography imaging of prostate cancer". Amino Acids. 39 (1): 11- ...
2015). Positron Emission Tomography: A Guide for Clinicians. India: Springer. doi:10.1007/978-81-322-2098-5. ISBN 978-81-322- ... 15O-water is used as a radioactive tracer for measuring and quantifying blood flow using positron emission tomography (PET) in ... Oxygen-15 decays with a half-life of about 2.04 minutes to nitrogen-15, emitting a positron. The positron quickly annihilates ... such as single-photon emission computed tomography (SPECT), cardiac magnetic resonance imaging (CMR) and dynamic computed ...
He is best known for his work on the positron emission tomography (PET). His research began in the 1950s with a series of ... A pioneer in nuclear medicine, he is best known for his research on the positron emission tomography (PET). He is considered ... Rich, D. A. (March 1997). "A brief history of positron emission tomography". Journal of Nuclear Medicine Technology. 25 (1): 4- ... "led the research that turned the positron emission tomography (PET) scanner from an intriguing concept to a medical tool used ...
Accordingly, the evaluation of non-invasive hypoxia detection methods, such as positron emission tomography (PET) and magnetic ... January 2015). "Imaging tumour hypoxia with positron emission tomography". British Journal of Cancer. 112 (2): 238-50. doi: ...
15O decays by positron emission with a half-life of 122 sec. It is used in positron emission tomography. 18F decays ... including single-photon emission computed tomography (SPECT), positron emission tomography (PET) and scintigraphy. The urea ... 11C decays by positron emission with a half-life of ca. 20 min. 11C is one of the isotopes often used in positron emission ... It is produced by the nuclear reaction 1H + 16O → 13N + 4He 13N is used in positron emission tomography (PET scan). ...
Positron emission tomography Birks, John B. (1964). The theory and practice of scintillation counting. Pergamon Press, Ltd. ...
A Bismuth Germanate-Avalanche Photodiode Module Designed for Use in High Resolution Positron Emission Tomography,. last. author ...
2010). "Clinical value of 18F-fluorodihydroxyphenylalanine positron emission tomography/computed tomography (18F-DOPA PET/CT) ... Positron-emission tomography (PET)[1] is a nuclear medicine functional imaging technique that is used to observe metabolic ... Wikimedia Commons has media related to Positron emission tomography.. *. Hofman, Michael S.; Hicks, Rodney J. (18 October 2016 ... Bailey, D.L; D.W. Townsend; P.E. Valk; M.N. Maisey (2005). Positron-Emission Tomography: Basic Sciences. Secaucus, NJ: Springer ...
... further source of research upon the neural processes of subitizing compared to counting comes from positron emission tomography ...
Positron emission mammography. *Tomosynthesis. *Xeromammography. *Galactography. *Breast MRI. *Breast ultrasound *Automated ... Computed tomography laser mammography (CTLM) is the trademark of Imaging Diagnostic Systems, Inc. (IDSI, United States) for its ... The technology uses laser in the same way computed tomography uses X-Rays, these beams travel through tissue and suffer ... Optical computed tomography for imaging the breast: first look // Proc. SPIE, 2000, Vol. 4082, p. 40-45. ...
Positron emission tomography (PET) was utilized to measure cerebral blood flow (CBF) in musicians possessing AP and musicians ... Utilizing positron emission tomography (PET), the findings showed that both linguistic and melodic phrases produced activation ... and positron emission tomography (PET). ...
PET skan (Positron Emission Tomography - PET Scan) adlanan qurğu vasitəsilə orqanizmin iltihab olan sahələri müəyyən edilir. ... "Positron Emission Tomography (PET Scan)"". Johns Hopkins Medicine. http://www.hopkinsmedicine.org/healthlibrary/test_procedures ... positron_emission_tomography_pet_scan_92,P07654/. İstifadə tarixi: 23 sentyabr, 2013. ... Electron-positron Annihilation and Pair Creation High School Teachers at CERN. *Tracks of electrons and positrons Science Photo ...
Positron-emitting radionuclide (tracer). See Positron emission tomography. *Altanserin a compound that binds to a serotonin ... Positron emission tomography (PET) a nuclear medical imaging technique that produces a three-dimensional image or picture of ... When labeled with the isotope fluorine-18 it is used as a radioligand in positron emission tomography (PET) studies of the ... The system detects pairs of gamma rays emitted indirectly by a positron-emitting radionuclide (tracer), which is introduced ...
... positron emission tomography (PET) with full-ring scanner 3-75: positron emission tomography with computed tomography (PET / CT ... single-photon emission computed tomography (SPECT) 3-73: single-photon emission computed tomography with computed tomography ( ... computed tomography (CT) 3-30...3-30: optical techniques 3-60...3-69: representation of the vascular system 3-70...3-76: ...
... in the 1970s and positron emission tomography (PET) in the 1980s, has moved radiation therapy from 3-D conformal to intensity- ... With Godfrey Hounsfield's invention of computed tomography (CT) in 1971, three-dimensional planning became a possibility and ...
Cranial computed topography, magnetic resonance imaging, and flurodeoxyglucose positron emission topography are just some of ... MRI or X-ray computed tomography abnormalities. *Oculomotor apraxia. *Microcephaly. *Macrocephaly. *Hyperreflexia ...
US CFR Title 21 parts 210 (GMP, general), 211 (GMP, finished pharmaceuticals), 212 (GMP, positron emission tomography drugs), ...
"Optical imaging of reporter gene expression using a positron-emission-tomography probe". Journal of Biomedical Optics. 15 (6): ... Radioisotopes such as the positron emitters 18F and 13N or beta emitters 32P or 90Y have measurable Cherenkov emission[14] and ... So the emission angle results in cos. ⁡. θ. =. 1. n. β. .. {\displaystyle \cos \theta ={\frac {1}{n\beta }}.}. Arbitrary ... reversing or steering Cherenkov emission at arbitrary angles given by the generalized relation: cos. ⁡. θ. =. 1. n. β. +. n. k ...
Brain PET(英语:Brain positron emission tomography). *Cardiac PET(英语:Cardiac PET) ... 3D / ECT(英语:emission computed tomography). *SPECT(英语:Single-photon emission computed tomography) *gamma ray: Myocardial ... Quantitative computed tomography(英语:Quantitative computed tomography). *Spiral computed tomography(英语:Spiral computed ... Computed tomography of the heart. *Computed tomography of the abdomen and pelvis(英语:Computed tomography of the abdomen and ...
2012). "No effects of short-term GSM mobile phone radiation on cerebral blood flow measured using positron emission tomography ... provide certification of antenna emission levels and assure compliance to ICNIRP standards and/or to other environmental ... there is no scientific proof that so-called shields significantly reduce exposure from electromagnetic emissions. Products that ...
... positron emission tomography)(PET) தனி ஒளியன் உமிழ்வு கணிப்புத் பிரித்துவரைவியல் (Single-photon emission computed tomography( ( ...
"A Bismuth Germanate-Avalanche Photodiode Module Designed for Use in High Resolution Positron Emission Tomography". IEEE ... delayed proton emission.[46] 84. Ge. through 87. Ge. isotopes also exhibit minor β−. delayed neutron emission decay paths.[46] ...
There are confocal variants that achieve resolution below the diffraction limit such as stimulated emission depletion ... "Confocal X-ray Fluorescence Imaging and XRF Tomography for Three Dimensional Trace Element Microanalysis". Microscopy and ... and used a rotating Nipkow disk to generate multiple excitation and emission pinholes.[16][21] ...
"Positron emission tomography imaging of prostate cancer". Amino Acids. 39 (1): 11-27. doi:10.1007/s00726-009-0394-9. PMC ...
... positron emission tomography (PET), single-photon emission tomography (SPECT). CT scans and MRI are the two techniques widely ... Computed tomography (CT) has become the diagnostic modality of choice for head trauma due to its accuracy, reliability, safety ... such as computed tomography (CT) scan, magnetic resonance imaging (MRI), diffusion tensor imaging (DTI) and magnetic resonance ... "Is cranial computed tomography unnecessary in children with a head injury and isolated vomiting?". BMJ. 365: l1875. doi: ...
An H2(15)O positron emission tomography study". Brain. 120 (Part 5): 761-84. doi:10.1093/brain/120.5.761. PMID 9183248.. ... Studies utilizing positron emission tomography (PET) have found during tasks that invoke disfluent speech, people who stutter ...
ಡಂಕನ್ ಮತ್ತು ಸಹೋದ್ಯೋಗಿಗಳು(2000) Positron Emission Tomographyಯನ್ನು ಬಳಸಿಕೊಂಡು ಐಕ್ಯೂ ಜತೆಗೆ ಉನ್ನತಮಟ್ಟದ ಅನುರೂಪತೆ ಹೊಂದಿರುವ ಸವಾಲುಗಳನ್ನು ...
Positron emission tomography - PET scan detectors, high-refractive-index glass, lutetium tantalate hosts for phosphors, ...
"Role of positron emission tomography-computed tomography in staging and early chemotherapy response evaluation in children with ...
In the case of beta+ radiation (positrons), the gamma radiation from the electron-positron annihilation reaction poses ... Computed Tomography, better known as C.T. Scans or CAT Scans have made an enormous contribution to medicine, however not ... One man is viewing his hand with a fluoroscope to optimise tube emissions, the other has his head close to the tube. No ... Electromagnetic radiation consists of emissions of electromagnetic waves, the properties of which depend on the wavelength. ...
X-ray computed tomography (X-ray CT), and positron emission tomography (PET). ... Redirected from Single photon emission computed tomography). Single-photon emission computed tomography (SPECT, or less ... Wikimedia Commons has media related to Single photon emission computed tomography.. *Human Health Campus, The official website ... Single-photon emission computed tomography. A SPECT slice of the distribution of technetium exametazime within a patient's ...
... radiolabeling of selective high-affinity 5-HT4 receptor ligands as prospective imaging probes for positron emission tomography ...
October 2007). "Elevated serotonin transporter binding in major depressive disorder assessed using positron emission tomography ...
Single-photon emission (SPECT). *Positron-emission tomography (PET). Therapy. *Fast-neutron. *Neutron capture therapy of cancer ... Greaves, R. G.; Tinkle, M. D.; Surko, C. M. (1994). "Creation and uses of positron plasmas". Physics of Plasmas. 1 (5): 1439. ... Examples are charged particle beams, an electron cloud in a Penning trap and positron plasmas.[58] ... Inductively coupled plasmas (ICP), formed typically in argon gas for optical emission spectroscopy or mass spectrometry ...
... positron emission tomography (PET), Near-infrared spectroscopy (NIRS) and other non-invasive scanning techniques to map anatomy ...
2010). "Clinical value of 18F-fluorodihydroxyphenylalanine positron emission tomography/computed tomography (18F-DOPA PET/CT) ... Positron-emission tomography (PET)[1] is a nuclear medicine functional imaging technique that is used to observe metabolic ... Bailey, D.L; D.W. Townsend; P.E. Valk; M.N. Maisey (2005). Positron-Emission Tomography: Basic Sciences. Secaucus, NJ: Springer ... Vardi, Y.; L. A. Shepp; L. Kaufman (1985). "A statistical model for positron emission tomography". Journal of the American ...
2010). "Clinical value of 18F-fluorodihydroxyphenylalanine positron emission tomography/computed tomography (18F-DOPA PET/CT) ... Positron-emission tomography (PET)[1] is a nuclear medicine functional imaging technique that is used to observe metabolic ... Bailey, D.L; D.W. Townsend; P.E. Valk; M.N. Maisey (2005). Positron-Emission Tomography: Basic Sciences. Secaucus, NJ: Springer ... Snyder, Donald L.; Miller, Michael I. (1985). "On the Use of the Method of Sieves for Positron Emission Tomography". IEEE ...
Positron emission tomography (PET), is a tool of major promise in biomedical research and clinical applications, which yields ... Positron Emission Tomography Positron Emission Tomography Image Positron Emission Tomograph Sodium Iodide Annihilation Photon ... Positron emission tomography (PET), is a tool of major promise in biomedical research and clinical applications, which yields ... Ter-Pogossian M.M. (1982) Positron Emission Tomography. In: Sklansky J., Bisconte JC. (eds) Biomedical Images and Computers. ...
... (PET) is a non-invasive nuclear imaging technique which uses radioactive tracers. PET scans ... What is positron emission tomography?. Positron emission tomography (PET) is a non-invasive nuclear imaging technique which ... Image of a breast and axillary nodes by conventional Positron emission tomography (PET) scan. Credit: National Cancer Institute ... Image pathology revealing a nodal metastasis from positron emission tomography (application in oncology) ...
A 46 year old man with Hodgkins lymphoma underwent 18F-FDG positron emission/computed tomography scanning to assess disease ... Pitfalls in positron emission tomography. BMJ 2017; 358 doi: https://doi.org/10.1136/bmj.j3805 (Published 14 September 2017) ...
Positron Emission Tomography Centre. Newcastle University , Positron Emission Tomography Centre , Our Research , Radiochemistry ... Positron Emission Tomography Centre. Building 15, Campus for Ageing and Vitality, Newcastle University, Newcastle upon Tyne, ... In the case of the positron-emitting isotope of fluorine (18F), the half-life is less than two hours, so the chemical synthesis ...
Prostate-specific membrane antigen positron emission tomography imaging has become a popular method for determining the stage ...
Positron emission tomography (PET) scan - Overview covers definition, risks, results of this imaging test used to diagnose ... A positron emission tomography (PET) scan is an imaging test that helps reveal how your tissues and organs are functioning. A ... Positron emission tomography. In: Mayo Clinic Cardiology: Concise Textbook. 4th ed. New York, N.Y.: Oxford University Press; ... Contemporary mapping of post-prostatectomy prostate cancer relapse with C-choline positron emission tomography and ...
La tomografia per emissió de positrons, TEP o PET (per les sigles en anglès de positron emission tomography), és lobtenció ... La tomografia per emissió de positrons, TEP o PET (per les sigles en anglès de positron emission tomography), és lobtenció ... Tomografi emisi positron (bahasa Inggris: Positron emission tomography, disingkat PET) adalah teknik kedokteran nuklir yang ... Tomografi emisi positron (bahasa Inggris: Positron emission tomography, disingkat PET) adalah teknik kedokteran nuklir yang ...
BP5502: NUCLEAR MEDICINE & POSITRON EMISSION TOMOGRAPHY (2020-2021). Last modified: 02 Feb 2021 11:05 ...
Positron emission tomography scanning is a diagnostic technique based on detection of positrons emitted by labeled substances ... Positron emission tomography (PET) scanning is a medical diagnostic technique based on the detection of positrons emitted by ... Positron emission tomography. The patient is drip-fed a radioactive chemical (1) that works its way around the body. The ... In the tissue, the substances emit positrons, which, in turn, release photons (particles of light). It is the detection of ...
Brain positron emission tomography is a form of positron emission tomography (PET) that is used to measure brain metabolism and ... February 2002). "A lipophilic thioflavin-T derivative for positron emission tomography (PET) imaging of amyloid in brain". ... "Evaluation of Microglial Activation in Multiple Sclerosis Patients Using Positron Emission Tomography". Frontiers in Neurology ... "Binding characteristics of radiofluorinated 6-dialkylamino-2-naphthylethylidene derivatives as positron emission tomography ...
positron emission tomography;. CT,. computed tomography;. FDG,. 2-[F-18]fluoro-2-deoxy-d-glucose;. DG,. 2-deoxy-d-[C-14]glucose ... positron emission tomography (PET), magnetic resonance imaging (MRI), x-ray computed tomography (CT), and single photon ... Positron emission tomography provides molecular imaging of biological processes Message Subject (Your Name) has sent you a ... Positron emission tomography provides molecular imaging of biological processes. Michael E. Phelps ...
Positron emission tomography (PET) scan. A PET scan is a nuclear medicine imaging test. It uses a form of radioactive sugar to ... Cancer information / Diagnosis and treatment / Tests and procedures / Positron emission tomography (PET scan) ... The radioactive material gives off tiny positively charged particles (positrons). A camera records the positrons and turns the ... Combined PET-CT scanning joins a PET scan and a computed tomography (CT) scan into one test. It may provide a more complete ...
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2010). "Clinical value of 18F-fluorodihydroxyphenylalanine positron emission tomography/computed tomography (18F-DOPA PET/CT) ... Positron-emission tomography (PET)[1] is a nuclear medicine functional imaging technique that is used to observe metabolic ... Wikimedia Commons has media related to Positron emission tomography.. *. Hofman, Michael S.; Hicks, Rodney J. (18 October 2016 ... Bailey, D.L; D.W. Townsend; P.E. Valk; M.N. Maisey (2005). Positron-Emission Tomography: Basic Sciences. Secaucus, NJ: Springer ...
Positron Emission Tomography (PET). Skip to the navigation Test Overview. Positron emission tomography (PET) is a test that ... A positron emission tomography (PET) scan is done to:. *Study the brains blood flow and metabolic activity. A PET scan can ... Positron emission tomography (PET). Normal:. Blood flow is normal and organs are working well. The flow and pattern of the ... Positron emission tomography (PET) is a test that uses a special type of camera and a tracer (radioactive substance) to look at ...
Positron-emission tomography synonyms, Positron-emission tomography pronunciation, Positron-emission tomography translation, ... English dictionary definition of Positron-emission tomography. n. Abbr. PET Tomography in which a computer-generated image of ... positron emission tomography (PET) scan. positron emission tomography. n. Abbr. PET. Tomography in which a computer-generated ... positron emission tomography. (redirected from Positron-emission tomography). Also found in: Thesaurus, Medical, Encyclopedia. ...
Positron emission tomography (PET or PET scan) is a specialized radiology procedure used to examine various body tissues to ... Positrons are emitted by the breakdown of the radionuclide. Gamma rays are created during the emission of positrons, and the ... PET works by using a scanning device (a machine with a large hole at its center) to detect positrons (subatomic particles) ... PET is also being used in conjunction with other diagnostic tests such as computed tomography (CAT scan) to provide more ...
A positron emission tomography uses a radioactive drug that emits positrons so that the drug can be traced using gamma rays ... A Positron Emission Tomography (PET) machine detects the energy emitted by positively charged particles called positrons. ... Single Photon Emission Computerized Tomography. Single Photon Emission Computed Tomography, a nuclear imaging diagnostic tool ... The Positron Emission Tomography machine detects these gamma rays and images are reconstructed by computer analysis. The tracer ...
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Positron Emission Tomography (PET) is a major diagnostic imaging tool used predominantly in clinical oncology for staging ...
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Positron Emission Tomography Scan (PET Scan) A whole-body PET scan provides information about the bodys chemistry and cell ... The FDG emits positrons that result in gamma rays that the scanner will record. A computer will process the information into a ...
Xia CF, Arteaga J, Chen G, Gangadharmath U, Gomez LF, Kasi D et al (2013) [(18)F]T807, a novel tau positron emission tomography ... Bohnen NI, Frey KA (2003) The role of positron emission tomography imaging in movement disorders. Neuroimaging Clin N Am 13(4): ... Müller M.L.T.M., Bohnen N.I. (2018) In Vivo Positron Emission Tomography of Extrastriatal Non-Dopaminergic Pathology in ... Bohnen NI, Albin RL, Koeppe RA, Wernette KA, Kilbourn MR, Minoshima S et al (2006) Positron emission tomography of ...
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  • Alternative methods of scanning include x-ray computed tomography (CT), magnetic resonance imaging (MRI) and functional magnetic resonance imaging (fMRI), ultrasound and single-photon emission computed tomography (SPECT). (wikipedia.org)
  • [3] A similar imaging process to PET is single-photon emission computed tomography (SPECT), which also uses radioligands to detect molecules in the brain, and is less expensive. (wikipedia.org)
  • The primary tools of the trade are positron-emission tomography (PET) and single-photon-emission computed tomography (SPECT) scans, with which scientists can find and measure changes in dopamine and other neurochemicals in the brain. (thefreedictionary.com)
  • More commonly, a technique much like the reconstruction of computed tomography (CT) and single photon emission computed tomography (SPECT) data is used, although the data set collected in PET is much poorer than CT, so reconstruction techniques are more difficult (see section below on image reconstruction of PET). (wikidoc.org)
  • The expense of the study and the limited availability of radiopharmaceuticals limit the use of PET, even though it is more sensitive than traditional nuclear scanning and single-photon emission computed tomography. (thefreedictionary.com)
  • Changing of regional blood flow in various anatomic structures (as a measure of the injected positron emitter) can be visualized and relatively quantified with a PET scan. (wikipedia.org)
  • In modern PET computed tomography scanners, three-dimensional imaging is often accomplished with the aid of a computed tomography X-ray scan performed on the patient during the same session, in the same machine. (wikipedia.org)
  • The scan is able to detect the positively charged particles (positrons), which are emitted as the radioactive tracer is broken down inside the body. (news-medical.net)
  • Image of a breast and axillary nodes by conventional Positron emission tomography (PET) scan. (news-medical.net)
  • A positron emission tomography (PET) scan is an imaging test that helps reveal how your tissues and organs are functioning. (mayoclinic.org)
  • The pictures from a PET scan provide information different from that uncovered by other types of scans, such as computerized tomography (CT) or magnetic resonance imaging (MRI). (mayoclinic.org)
  • Regional tracer uptake in various anatomic structures can be visualized and relatively quantified in terms of injected positron emitter within a PET scan. (wikipedia.org)
  • Combined PET-CT scanning joins a PET scan and a computed tomography (CT) scan into one test. (cancer.ca)
  • PET scan pictures do not show as much detail as computed tomography (CT) scans or magnetic resonance imaging (MRI) because the pictures show only the location of the tracer. (cigna.com)
  • A positron emission tomography (PET) scan is done in a hospital nuclear medicine department or at a special PET center by a radiologist or nuclear medicine specialist and a technologist. (cigna.com)
  • Positron emission tomography (PET or PET scan) is a specialized radiology procedure used to examine various body tissues to identify certain conditions. (hopkinsmedicine.org)
  • Thus, PET may detect biochemical changes in an organ or tissue that can identify the onset of a disease process before anatomical changes related to the disease can be seen with other imaging processes, such as computed tomography (CT scan) or magnetic resonance imaging (MRI) . (hopkinsmedicine.org)
  • PET is also being used in conjunction with other diagnostic tests such as computed tomography (CAT scan) to provide more definitive information about malignant (cancerous) tumors and other lesions. (hopkinsmedicine.org)
  • Other related procedures that may be performed include computed tomography (CT scan) and magnetic resonance imaging (MRI) . (hopkinsmedicine.org)
  • PET scanners are often used in combination with the computed tomography or CT scan in modern PET-CT scan machines. (medindia.net)
  • PET scan, Computerized Tomography and Magnetic Resonance Imaging are all non-invasive surgical scans that help the doctor look inside the body. (medindia.net)
  • A positron emission tomography (PET) scan is a type of nuclear medicine imaging test. (rochester.edu)
  • To conduct the scan, a short-lived radioactive tracer isotope, which decays by emitting a positron, which also has been chemically incorporated into a metabolically active molecule, is injected into the living subject (usually into blood circulation). (wikidoc.org)
  • A positron emission tomography (PET) scan is used to look at organs inside of your body, such as your heart and brain. (vanderbilthealth.com)
  • PET (Positron Emission Tomography) and CT (Cat Scan or computed tomography) are both standard imaging tools that physicians use to pinpoint disease in the body. (wcahospital.org)
  • A positron emission tomography (PET) scan is a type of nuclear imaging test that shows the metabolic activities (energy usage) of your brain. (mayfieldclinic.com)
  • A PET scan integrates two technologies to view your body: computed tomography (CT) and a radioactive material called a tracer. (mayfieldclinic.com)
  • Assess the ability of fludeoxyglucose F 18 positron emission tomography to predict relapse requiring adjuvant chemotherapy in patients with high-risk stage I non-seminomatous or mixed seminoma/non-seminomatous germ cell tumor of the testis who are on current management protocols. (clinicaltrials.gov)
  • Determine the efficacy of fludeoxyglucose F 18 positron emission tomography imaging in detecting lesions that would preclude esophagectomy in patients with carcinoma of the thoracic esophagus or gastroesophageal junction. (knowcancer.com)
  • Fluorine-18 fluorodeoxyglucose positron emission tomography, gallium-67 scintigraphy, and conventional staging for Hodgkin's disease and non-Hodgkin's lymphoma," American Journal of Medicine , vol. 112, no. 4, pp. 262-268, 2002. (hindawi.com)
  • The usefulness of 18 F-fluorodeoxyglucose positron emission tomography ( 18 F-FDG-PET) and a comparison of 18 F-FDG-PET with 67 gallium scintigraphy in the evaluation of lymphoma: relation to histologic subtypes based on the World Health Organization classification," Cancer , vol. 110, no. 3, pp. 652-659, 2007. (hindawi.com)
  • What is the role of positron emission tomography (PET) scanning in the workup of colon cancer? (medscape.com)
  • What is the role of positron emission tomography (PET) in the workup of renal cell carcinoma (RCC)? (medscape.com)
  • This platform employs powerful mathematical algorithms and computer processors to render a 3-D representation of targeted patient anatomy, using diagnostic imaging data acquired preoperatively from computed tomography (CT), magnetic resonance imaging (MRI) or positron-emission tomography (PET) scans. (thefreedictionary.com)
  • PET/CT (Positron Emission Tomography) scans use radioactive materials to diagnose the presence of disease in the body. (hackensackumc.org)
  • Positron Emission Tomography (PET) is non-invasive diagnostic imaging test that scans the metabolic function of the body. (wcahospital.org)
  • Positron emission tomography (PET) is a non-invasive nuclear imaging technique which uses radioactive tracers. (news-medical.net)
  • Abstract Several positron emission tomography (PET) tracers, particularly [18F]fluorodeoxyglucose ([18F]FDG), have been shown to identify temporal lobe epileptic foci reliably and help predict outcome from temporal lobectomy. (semanticscholar.org)
  • PET Examples Imaging Goal Reconstruction/Data Requirements Method of Data Acquisition in PET Positron Decay/Annihilation Detectors/Scanner PET Tracers Data Acquisition Modes (2D/3D) Attenuation Degrading Effects Combined PET and CT. (slideserve.com)
  • Positron nuclide-labeled AA tracers can overcome limitations of 18 F-FDG for tumors imaging, and give information about AA metabolism in tumor. (frontiersin.org)
  • The usefulness of PET stems from the fact that some elements of fundamental importance in the investigation biological processes possess radionuclides which decay by the emission of positrons. (springer.com)
  • Tomography in which a computer-generated image of local metabolic and physiological functions in tissues is produced through the detection of gamma rays that are emitted when introduced radionuclides decay and release positrons. (thefreedictionary.com)
  • Because positron emission decreases proton number relative to neutron number, positron decay happens typically in large "proton-rich" radionuclides. (wn.com)
  • An imaging technique using compounds labelled with short-lived positron-emitting radionuclides (such as carbon-11, nitrogen-13, oxygen-15 and fluorine-18) to measure cell metabolism. (jove.com)
  • This course will deal with the cyclotron production of radionuclides and their uses, radiation safety for positron emitting isotopes, formulation of radiopharmaceuticals, and operation of imaging equipment. (rmu.edu)
  • PET uses positron emissions from specific radionuclides (oxygen, nitrogen, carbon, and fluorine) to produce detailed functional images within the body. (thefreedictionary.com)
  • When the positrons are emitted from the decay of the tracer, they are able to travel a short distance in the tissue, during which they interact with electrons. (news-medical.net)
  • Positron emission or beta plus decay (β + decay) is a particular type of radioactive decay and a subtype of beta decay , in which a proton inside a radionuclide nucleus is converted into a neutron while releasing a positron and an electron neutrino ( ν e ). (wn.com)
  • The positron is a type of beta particle (β + ), the other beta particle being the electron (β − ) emitted from the β − decay of a nucleus. (wn.com)
  • Positron decay results in nuclear transmutation , changing an atom of a chemical element into an atom of an element with an atomic number that is less by one unit. (wn.com)
  • Positron emission should not be confused with electron emission or beta minus decay (β − decay), which occurs when a neutron turns into a proton and the nucleus emits an electron and an antineutrino. (wn.com)
  • As the radioisotope undergoes positron emission decay (also known as positive beta decay), it emits a positron, the antimatter counterpart of an electron. (wikidoc.org)
  • PET uses a positron camera (tomograph) to measure the decay of these radioisotopes. (cms.gov)
  • The particular radioactive atoms involved that emit the positrons when they decay aren't readily found in nature. (straightdope.com)
  • Positron-emission tomography (PET) ( 4 ) is a highly sensitive, quantitative, and noninvasive detection method that provides three-dimensional information within the whole animal or patient. (pnas.org)
  • The usefulness of positron-emission tomography (PET) for noninvasive assessment of several biological parameters of neoplastic tissue has been reviewed. (nih.gov)
  • Positron emission tomography (PET) can provide noninvasive molecular, functional and metabolic information. (frontiersin.org)
  • Dual modality imaging combining positron emissions tomography (PET) and magnetic resonance (MR) imaging can improve diagnosis and disease tracking by providing concurrent, high-resolution anatomical and functional views. (bruker.com)
  • Epilepsy diagnosis: positron emission tomography. (semanticscholar.org)
  • article{Kumar2012EpilepsyDP, title={Epilepsy diagnosis: positron emission tomography. (semanticscholar.org)
  • Here, we show that single human breast cancer cells loaded with mesoporous silica nanoparticles concentrating the 68 Ga radioisotope and injected into immunodeficient mice can be tracked in real time from the pattern of annihilation photons detected using positron emission tomography, with respect to anatomical landmarks derived from X-ray computed tomography. (nature.com)
  • After travelling up to a few millimeters the positron encounters and annihilates with an electron, producing a pair of annihilation ( gamma ) photons moving in almost opposite directions. (wikidoc.org)
  • Radiotracer distribution is detected via emitted gamma photons resulting from positron-electron annihilation. (covance.com)
  • The most significant fraction of electron-positron decays result in two 511 keV photons being emitted at almost 180 degrees to each other, hence it is possible to localise their source along a straight line of coincidence (also called formally the 'line of response' or LOR). (biology-online.org)
  • M.M. Ter-Pogossian, M.E. Phelps, E.J. Hoffman, et al: A positron emission transaxial tomograph for nuclear imaging (PETT), Radiology 114: 89-98, 1975. (springer.com)
  • M.M. Ter-Pogossian, N.A. Mullani, J. Hood, C.S. Higgins, C.M. Currie, A multi-slice positron emission computed tomograph (PETT IV) yielding transverse and longitudinal images, Radiology 128: 477-484, 1978. (springer.com)
  • P. R. Mueller, J. T. Ferrucci Jr., and W. P. Harbin, "Appearance of lymphomatous involvement of the mesentery by ultrasonography and body computed tomography: the "sandwich sign"," Radiology , vol. 134, no. 2, pp. 467-473, 1980. (hindawi.com)
  • Positron-emission tomography ( PET ) [1] is a nuclear medicine functional imaging technique that is used to observe metabolic processes in the body. (wikipedia.org)
  • S.E. Derenzo, T.F. Budinger, Resolution limit for positron-imaging devices, J Nucl Med 18: 491, 1977. (springer.com)
  • Essential for students, science and medical graduates who want to understand the basic science of Positron Emission Tomography (PET), this book describes the physics, chemistry, technology and overview of the clinical uses behind the science of PET and the imaging techniques it uses. (springer.com)
  • Newcastle Positron Emission Tomography (PET) Centre has been set-up to provide non-invasive imaging facilities for the University and its partners. (ncl.ac.uk)
  • Positron emission tomography (PET) is an imaging technique that uses radioactive substances to visualize and measure metabolic processes in the body. (dbpedia.org)
  • Positron emission tomography (PET) is a functional imaging technique that uses radioactive substances known as radiotracers to visualize and measure changes in metabolic processes, and in other physiological activities including blood flow, regional chemical composition, and absorption. (wikipedia.org)
  • Diseases are biological processes, and molecular imaging with positron emission tomography (PET) is sensitive to and informative of these processes. (pnas.org)
  • Molecular imaging by PET, optical technologies, magnetic resonance imaging, single photon emission tomography, and other technologies are assisting in moving research findings from in vitro biology to in vivo integrative mammalian biology of disease. (pnas.org)
  • PET is an analytical imaging technology developed ( 1 - 5 ) to use compounds labeled with positron emitting radioisotopes as molecular probes to image and measure biochemical processes of mammalian biology in vivo (Fig. 1 ). (pnas.org)
  • RATIONALE: Imaging procedures such as positron emission tomography may improve the ability to detect the extent of cancer and allow doctors to plan more effective treatment for patients who have testicle cancer. (clinicaltrials.gov)
  • Patients receive fludeoxyglucose F 18 (FDG) IV followed 1 hour later by positron emission tomography (PET) imaging. (clinicaltrials.gov)
  • These include computed tomography (CT) or magnetic resonance imaging (MRI). (rochester.edu)
  • Positron Emission Tomography (PET) is a major diagnostic imaging tool used predominantly in clinical oncology for staging various cancers, assessing treatment strategies, and monitoring the effects of therapies. (federallabs.org)
  • ST provides a very wide portfolio of products from discretes to 32 bit digital processors and memories that help to further enhance imaging within positron emission tomography. (electronicproducts.com)
  • Positron emission tomography ( PET ) is a nuclear medicine , functional imaging technique that is used to observe metabolic processes in the body.The system detects pairs of gamma rays emitted indirectly by a positron -emitting radionuclide ( tracer ), which is introduced into the body on a biologically active molecule. (wn.com)
  • Derivatives of dibenzothiophene for positron emission tomography imaging of α7-nicotinic acetylcholine receptors. (nih.gov)
  • A new series of derivatives of 3-(1,4-diazabicyclo[3.2.2]nonan-4-yl)dibenzo[b,d]thiophene 5,5-dioxide with high binding affinities and selectivity for α7-nicotinic acetylcholine receptors (α7-nAChRs) (Ki = 0.4-20 nM) has been synthesized for positron emission tomography (PET) imaging of α7-nAChRs. (nih.gov)
  • Positron Emission Tomography (PET) is a non-invasive diagnostic imaging procedure that is able to detect biochemical reactions e.g. metabolism and abnormal distribution of cell receptors within body tissues. (wellmark.com)
  • Positron emission tomography ( PET ) is a nuclear medicine medical imaging technique which produces a three-dimensional image or map of functional processes in the body. (wikidoc.org)
  • The UC Davis School of Veterinary Medicine has achieved another milestone in clinical equine imaging with the first successful use of positron emission tomography (PET) on a standing horse. (ucdavis.edu)
  • Positron emission tomography (PET) imaging remains controversial in kidney cancer. (medscape.com)
  • Functional imaging studies, such as 11 C-methionine positron emission tomography (MET-PET), have demonstrated increased metabolic activity due to increased amino acid transport in glioma cells compared to normal brain tissue [ 2 ]. (hindawi.com)
  • Positron emission tomography (PET) played a minor role in HCC imaging so far largely due to the fact that the commonly used radiotracer, 2-[ 18 F]-2-deoxy-D-glucose (FDG) has little uptake in a number of HCC cases leading to a high false positive rate. (omicsonline.org)
  • To assess whether whole-body positron emission tomography and computed tomography (PET-CT) plus cranial imaging correctly upstages cancer in more patients with NSCLC than does conventional staging plus cranial imaging. (nih.gov)
  • Positron emission tomography (PET) is a nuclear medicine imaging technique that generates 3D images of an injected PET radioisotope-labeled molecule in the body. (covance.com)
  • Patients receive fludeoxyglucose F 18 (FDG) IV followed 45-60 minutes later by positron emission tomography (PET) imaging. (knowcancer.com)
  • Use of positron emission tomography for response assessment of lymphoma: consensus of the imaging subcommittee of international harmonization project in lymphoma," Journal of Clinical Oncology , vol. 25, no. 5, pp. 571-578, 2007. (hindawi.com)
  • To investigate the associations of metabolite levels derived from magnetic resonance spectroscopic imaging (MRSI) and 18 F-fluciclovine positron emission tomography (PET) with prostate tissue characteristics. (frontiersin.org)
  • Positron emission tomography (PET) allows diagnostic imaging of metabolic function using radioisotopes. (nps.org.au)
  • Positron emission tomography (PET) scanning allows non-invasive diagnostic imaging of metabolic processes using short-lived radioisotopes. (nps.org.au)
  • In contrast to computerised tomography (CT) and magnetic resonance imaging (MRI), which provide information on structure, PET can quantify biochemical and physiological function. (nps.org.au)
  • Radiotracer synthesis is an ideal application for microfluidics because only nanogram quantities are needed for positron emission tomography (PET) imaging. (rsc.org)
  • Positron-emitting nuclide labeled AAs are interesting probes and are of great importance for imaging tumors using positron emission tomography (PET). (frontiersin.org)
  • Positron emission tomography (PET) scanning is a medical diagnostic technique based on the detection of positrons emitted by labeled substances introduced into the body. (daviddarling.info)
  • PURPOSE: Diagnostic trial to study the effectiveness of positron emission tomography using fludeoxyglucose F 18 in predicting relapse in patients who have stage I germ cell tumor of the testicle. (clinicaltrials.gov)
  • The system detects pairs of gamma rays emitted indirectly by a positron -emitting radionuclide ( tracer ), which is introduced into the body on a biologically active molecule. (wikipedia.org)
  • Positron emission tomography (PET), is a tool of major promise in biomedical research and clinical applications, which yields images representing the distribution of a systemically administered positron-emitting radionuclide in transverse tomographic sections of the body of human subjects or experimental animals. (springer.com)
  • PET works by using a scanning device (a machine with a large hole at its center) to detect positrons (subatomic particles) emitted by a radionuclide in the organ or tissue being examined. (hopkinsmedicine.org)
  • Positrons are emitted by the breakdown of the radionuclide. (hopkinsmedicine.org)
  • The tracer, which is a radioactive drug, is a positron-emitting radionuclide that emits gamma rays. (medindia.net)
  • Positron emission tomography (PET) scanning is emerging as a very useful modality for staging and assessment of colorectal cancers. (medscape.com)
  • Regional assessment of myocardial metabolic integrity in vivo by positron-emission tomography with 11C-labeled palmitate. (ahajournals.org)
  • The positron radiopharmaceuticals generally have short half-lives, ranging from a few seconds to a few hours, and therefore they must be produced in a cyclotron located near where the test is being done. (thefreedictionary.com)
  • Positron Emission Tomography (PET) enables investigators to measure a wide range of in vivo physiology in human beings and laboratory animals with a non-invasive research tool. (yale.edu)
  • We offer in vivo micro positron emission tomography (PET) study design, execution and data analysis across a broad spectrum of disease models and analytic techniques. (covance.com)
  • The system detects pairs of gamma rays emitted indirectly by a positron -emitting radioligand , most commonly fluorine-18 , which is introduced into the body on a biologically active molecule called a radioactive tracer . (wikipedia.org)
  • Gamma rays are created during the emission of positrons, and the scanner then detects the gamma rays. (hopkinsmedicine.org)
  • The Positron Emission Tomography machine detects these gamma rays and images are reconstructed by computer analysis. (medindia.net)
  • PET works by using a special camera that detects positrons emitted by the radioactive tracer in the organ or tissue being examined. (rochester.edu)
  • PET, which stands for positron emission tomography, helps examine metabolic activity within patients. (electronicproducts.com)
  • Positron emission tomography (PET) is a type of nuclear medicine procedure that measures metabolic activity of the cells of body tissues. (nyhq.org)
  • We propose that this polarization correlation can be exploited in Positron Emission Tomography (PET), which relies crucially on accurate coincidence detection of photon pairs. (spie.org)
  • We demonstrate that the unique identification of true photon pairs with their polarization correlation can dramatically enhance overall PET image quality, especially for high emission rates, when conventional, energy- based coincidence detection methods become increasingly unreliable. (spie.org)
  • An injected radioactive tracer gives off subatomic particles, known as positrons, as it decays. (cms.gov)
  • As the short-lived isotope decays (110 minute half-life), it emits a positron. (biology-online.org)
  • Positron emission tomography (PET) was used to compare regional cerebral blood flow (rCBF) in young (mean 26 years) and old (mean 70 years) subjects while they were encoding, recognizing, and recalling word pairs. (jneurosci.org)
  • Using positron emission tomography in nine patients with minor strokes, unilateral internal carotid artery occlusion, and good collateral circulation through the anterior portion of the circle of Willis, we analyzed regional cerebral blood flow, cerebral metabolic rate of oxygen, oxygen extraction fraction, and cerebral blood volume. (ahajournals.org)
  • Using [ 15 O]H 2 O positron emission tomography, changes in normalized regional cerebral blood flow (rCBF) were assessed while participants repetitively wrote a stereotyped word with their right hand. (jneurosci.org)
  • That distribution is most accurately determined through use of a PET scanner, to localize and quantify the tracer molecules, in which have been incorporated positron-emitting isotopes. (nih.gov)
  • A positron emission tomography uses a radioactive drug that emits positrons so that the drug can be traced using gamma rays that it produces. (medindia.net)
  • The FDG emits positrons that result in gamma rays that the scanner will record. (lhsc.on.ca)
  • The interaction of the positron and the electron causes both to be destroyed in an annihilation reaction. (news-medical.net)
  • We evaluated the utility of fluorine-18 l -3,4-dihydroxyphenylalanine ([ 18 F]-DOPA) positron emission tomography (PET) to identify focal pancreatic lesions in 14 CHI patients, 11 of which carried mutations in the ABCC8 gene (age 1-42 months). (diabetesjournals.org)
  • Current positron emission tomography (PET) radioligands for detection of Abeta amyloid in Alzheimer's disease (AD) are not ideal for quantification. (nih.gov)
  • This research paper presents clinical outcomes of hypofractionated high-dose irradiation by intensity-modulated radiation therapy (Hypo-IMRT) with 11 C-methionine positron emission tomography (MET-PET) data for the treatment of glioblastoma multiforme (GBM). (hindawi.com)
  • Role of 18 F-FDG PET/CT in staging and follow-up of lymphoma in pediatric and young adult patients," Journal of Computer Assisted Tomography , vol. 30, no. 4, pp. 689-694, 2006. (hindawi.com)
  • PET measures emissions from radioactively labeled metabolically active chemicals that have been injected into the bloodstream. (wikipedia.org)
  • Detection of amyloid in Alzheimer's disease with positron emission tomography using [11C]AZD2184. (nih.gov)
  • The PET scanner translates the emissions from the radioactivity as the positron combines with the negative electrons from the tissues and forms gamma rays that can be detected by the scanner. (thefreedictionary.com)
  • Global Positron Emission Tomography Scanners Market Professional Survey Report 2016-2022" Purchase This Report by calling ResearchnReports.com at +1-888-631-6977. (medgadget.com)
  • This market report is a thorough analysis of the existing situation and the anticipated condition for Positron Emission Tomography Scanners market. (medgadget.com)
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  • 18fluorodeoxyglucose positron emission tomography in the prediction of relapse in patients with high-risk, clinical stage I nonseminomatous germ cell tumors: preliminary report of MRC Trial TE22--the NCRI Testis Tumour Clinical Study Group. (clinicaltrials.gov)
  • Detectnet is a positron emission tomography (PET) agent indicated for the localization of somatostatin receptor positive neuroendocrine tumors (NETs) in adult patients. (drugs.com)
  • We therefore investigated presynaptic dopaminergic function in 6 female FMS patients in comparison to 8 age- and gender-matched controls as assessed by positron emission tomography with 6-[(18)F]fluoro-L-DOPA as a tracer. (prohealth.com)
  • Purpose: To investigate the prognostic role of metabolic response by the use of serial sets of positron emission tomography/computed tomography (PET/CT) in patients with cervical cancer who were treated with concurrent chemoradiation therapy (CCRT). (osti.gov)
  • Positrons are anti-electrons-right? (straightdope.com)
  • Actually, the fact that positrons annihilate with electrons is the basis for how PET works . (straightdope.com)
  • The radioactive material gives off tiny positively charged particles (positrons). (cancer.ca)
  • QY Research's latest publication, titled global Positron Emission Computed Tomography market, offers an insightful take on the drivers and restraints present in the market. (openpr.com)
  • Due to the pandemic, we have included a special section on the Impact of COVID 19 on the Positron Emission Computed Tomography Market which would mention How the Covid-19 is Affecting the Positron Emission Computed Tomography Industry, Market Trends and Potential Opportunities in the COVID-19 Landscape, Covid-19 Impact on Key Regions and Proposal for Positron Emission Computed Tomography Players to Combat Covid-19 Impact. (openpr.com)
  • This is illustrated by detection of biological abnormalities in neurological disorders with no computed tomography or MRI anatomic changes, as well as even before symptoms are expressed. (pnas.org)
  • The positron emitting radioisotopes used are usually produced by a cyclotron, and chemicals are labeled with these radioactive atoms. (wikipedia.org)
  • A 46 year old man with Hodgkin's lymphoma underwent 18 F-FDG positron emission/computed tomography scanning to assess disease response after three cycles of chemotherapy. (bmj.com)
  • Brain positron emission tomography is a form of positron emission tomography (PET) that is used to measure brain metabolism and the distribution of exogenous radiolabeled chemical agents throughout the brain. (wikipedia.org)
  • Coronary microvascular function, myocardial metabolism, and energetics in hypertrophic cardiomyopathy: insights from positron emission tomography. (biomedsearch.com)
  • Positron emission tomography (PET) is becoming more frequently used by medicinal chemists to facilitate the selection of the most promising lead compounds for further evaluation. (rsc.org)