An imaging technique using compounds labelled with short-lived positron-emitting radionuclides (such as carbon-11, nitrogen-13, oxygen-15 and fluorine-18) to measure cell metabolism. It has been useful in study of soft tissues such as CANCER; CARDIOVASCULAR SYSTEM; and brain. SINGLE-PHOTON EMISSION-COMPUTED TOMOGRAPHY is closely related to positron emission tomography, but uses isotopes with longer half-lives and resolution is lower.
Tomography using radioactive emissions from injected RADIONUCLIDES and computer ALGORITHMS to reconstruct an image.
The compound is given by intravenous injection to do POSITRON-EMISSION TOMOGRAPHY for the assessment of cerebral and myocardial glucose metabolism in various physiological or pathological states including stroke and myocardial ischemia. It is also employed for the detection of malignant tumors including those of the brain, liver, and thyroid gland. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1162)
Compounds that are used in medicine as sources of radiation for radiotherapy and for diagnostic purposes. They have numerous uses in research and industry. (Martindale, The Extra Pharmacopoeia, 30th ed, p1161)
The use of combination of imaging techniques or platforms (e.g., MRI SCAN and PET SCAN) encompassing aspects of anatomical, functional, or molecular imaging methods.
Unstable isotopes of fluorine that decay or disintegrate emitting radiation. F atoms with atomic weights 17, 18, and 20-22 are radioactive fluorine isotopes.
Unstable isotopes of carbon that decay or disintegrate emitting radiation. C atoms with atomic weights 10, 11, and 14-16 are radioactive carbon isotopes.
Unstable isotopes of oxygen that decay or disintegrate emitting radiation. O atoms with atomic weights 13, 14, 15, 19, and 20 are radioactive oxygen isotopes.
Tomography using x-ray transmission and a computer algorithm to reconstruct the image.
The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM.
Non-invasive method of demonstrating internal anatomy based on the principle that atomic nuclei in a strong magnetic field absorb pulses of radiofrequency energy and emit them as radiowaves which can be reconstructed into computerized images. The concept includes proton spin tomographic techniques.
Unstable isotopes of nitrogen that decay or disintegrate emitting radiation. N atoms with atomic weights 12, 13, 16, 17, and 18 are radioactive nitrogen isotopes.
Unstable isotopes of copper that decay or disintegrate emitting radiation. Cu atoms with atomic weights 58-62, 64, and 66-68 are radioactive copper isotopes.
A substituted benzamide that has antipsychotic properties. It is a dopamine D2 receptor (see RECEPTORS, DOPAMINE D2) antagonist.
The circulation of blood through the BLOOD VESSELS of the BRAIN.
Radioactive substances added in minute amounts to the reacting elements or compounds in a chemical process and traced through the process by appropriate detection methods, e.g., Geiger counter. Compounds containing tracers are often said to be tagged or labeled. (Hawley's Condensed Chemical Dictionary, 12th ed)
A method of computed tomography that uses radionuclides which emit a single photon of a given energy. The camera is rotated 180 or 360 degrees around the patient to capture images at multiple positions along the arc. The computer is then used to reconstruct the transaxial, sagittal, and coronal images from the 3-dimensional distribution of radionuclides in the organ. The advantages of SPECT are that it can be used to observe biochemical and physiological processes as well as size and volume of the organ. The disadvantage is that, unlike positron-emission tomography where the positron-electron annihilation results in the emission of 2 photons at 180 degrees from each other, SPECT requires physical collimation to line up the photons, which results in the loss of many available photons and hence degrades the image.
2-Deoxy-D-arabino-hexose. An antimetabolite of glucose with antiviral activity.
Any visual display of structural or functional patterns of organs or tissues for diagnostic evaluation. It includes measuring physiologic and metabolic responses to physical and chemical stimuli, as well as ultramicroscopy.
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
A technique of inputting two-dimensional images into a computer and then enhancing or analyzing the imagery into a form that is more useful to the human observer.
Imaging techniques used to colocalize sites of brain functions or physiological activity with brain structures.
The use of molecularly targeted imaging probes to localize and/or monitor biochemical and cellular processes via various imaging modalities that include RADIONUCLIDE IMAGING; ULTRASONOGRAPHY; MAGNETIC RESONANCE IMAGING; FLUORESCENCE IMAGING; and MICROSCOPY.
The creation of a visual display of the inside of the entire body of a human or animal for the purposes of diagnostic evaluation. This is most commonly achieved by using MAGNETIC RESONANCE IMAGING; or POSITRON EMISSION TOMOGRAPHY.
Self-generated faint acoustic signals from the inner ear (COCHLEA) without external stimulation. These faint signals can be recorded in the EAR CANAL and are indications of active OUTER AUDITORY HAIR CELLS. Spontaneous otoacoustic emissions are found in all classes of land vertebrates.
Accumulation of a drug or chemical substance in various organs (including those not relevant to its pharmacologic or therapeutic action). This distribution depends on the blood flow or perfusion rate of the organ, the ability of the drug to penetrate organ membranes, tissue specificity, protein binding. The distribution is usually expressed as tissue to plasma ratios.
Unstable isotopes of gallium that decay or disintegrate emitting radiation. Ga atoms with atomic weights 63-68, 70 and 72-76 are radioactive gallium isotopes.
A beta-hydroxylated derivative of phenylalanine. The D-form of dihydroxyphenylalanine has less physiologic activity than the L-form and is commonly used experimentally to determine whether the pharmacological effects of LEVODOPA are stereospecific.
Isotopes that exhibit radioactivity and undergo radioactive decay. (From Grant & Hackh's Chemical Dictionary, 5th ed & McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
The statistical reproducibility of measurements (often in a clinical context), including the testing of instrumentation or techniques to obtain reproducible results. The concept includes reproducibility of physiological measurements, which may be used to develop rules to assess probability or prognosis, or response to a stimulus; reproducibility of occurrence of a condition; and reproducibility of experimental results.
In screening and diagnostic tests, the probability that a person with a positive test is a true positive (i.e., has the disease), is referred to as the predictive value of a positive test; whereas, the predictive value of a negative test is the probability that the person with a negative test does not have the disease. Predictive value is related to the sensitivity and specificity of the test.
Methods which attempt to express in replicable terms the extent of the neoplasm in the patient.
A nitroimidazole that sensitizes normally radio-resistant hypoxic cells to radiation. It may also be directly cytotoxic to hypoxic cells and has been proposed as an antineoplastic.
Unstable isotopes of rubidium that decay or disintegrate emitting radiation. Rb atoms with atomic weights 79-84, and 86-95 are radioactive rubidium isotopes.
A subfamily of G-PROTEIN-COUPLED RECEPTORS that bind the neurotransmitter DOPAMINE and modulate its effects. D2-class receptor genes contain INTRONS, and the receptors inhibit ADENYLYL CYCLASES.
The circulation of blood through the CORONARY VESSELS of the HEART.
A primary source of energy for living organisms. It is naturally occurring and is found in fruits and other parts of plants in its free state. It is used therapeutically in fluid and nutrient replacement.
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
Gases, fumes, vapors, and odors escaping from the cylinders of a gasoline or diesel internal-combustion engine. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed & Random House Unabridged Dictionary, 2d ed)
Amides of salicylic acid.
Elements of limited time intervals, contributing to particular results or situations.
Combination or superimposition of two images for demonstrating differences between them (e.g., radiograph with contrast vs. one without, radionuclide images using different radionuclides, radiograph vs. radionuclide image) and in the preparation of audiovisual materials (e.g., offsetting identical images, coloring of vessels in angiograms).
A potent benzodiazepine receptor antagonist. Since it reverses the sedative and other actions of benzodiazepines, it has been suggested as an antidote to benzodiazepine overdoses.
A genus of the subfamily CERCOPITHECINAE, family CERCOPITHECIDAE, consisting of five named species: PAPIO URSINUS (chacma baboon), PAPIO CYNOCEPHALUS (yellow baboon), PAPIO PAPIO (western baboon), PAPIO ANUBIS (or olive baboon), and PAPIO HAMADRYAS (hamadryas baboon). Members of the Papio genus inhabit open woodland, savannahs, grassland, and rocky hill country. Some authors consider MANDRILLUS a subgenus of Papio.
The study of the chemical and physical phenomena of radioactive substances.
The thin layer of GRAY MATTER on the surface of the CEREBRAL HEMISPHERES that develops from the TELENCEPHALON and folds into gyri and sulchi. It reaches its highest development in humans and is responsible for intellectual faculties and higher mental functions.
Tumors or cancer of the LUNG.
Techniques for labeling a substance with a stable or radioactive isotope. It is not used for articles involving labeled substances unless the methods of labeling are substantively discussed. Tracers that may be labeled include chemical substances, cells, or microorganisms.
A class of organic compounds containing a ring structure made up of more than one kind of atom, usually carbon plus another atom. The ring structure can be aromatic or nonaromatic.
Methods developed to aid in the interpretation of ultrasound, radiographic images, etc., for diagnosis of disease.
A drug formerly used as an antipsychotic and treatment of various movement disorders. Tetrabenazine blocks neurotransmitter uptake into adrenergic storage vesicles and has been used as a high affinity label for the vesicle transport system.
A species of baboon in the family CERCOPITHECIDAE with a somewhat different social structure than PAPIO HAMADRYAS. They inhabit several areas in Africa south of the Sahara.
The treatment of a disease or condition by several different means simultaneously or sequentially. Chemoimmunotherapy, RADIOIMMUNOTHERAPY, chemoradiotherapy, cryochemotherapy, and SALVAGE THERAPY are seen most frequently, but their combinations with each other and surgery are also used.
Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.
Striped GRAY MATTER and WHITE MATTER consisting of the NEOSTRIATUM and paleostriatum (GLOBUS PALLIDUS). It is located in front of and lateral to the THALAMUS in each cerebral hemisphere. The gray substance is made up of the CAUDATE NUCLEUS and the lentiform nucleus (the latter consisting of the GLOBUS PALLIDUS and PUTAMEN). The WHITE MATTER is the INTERNAL CAPSULE.
Non-invasive methods of visualizing the CENTRAL NERVOUS SYSTEM, especially the brain, by various imaging modalities.
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
Transfer of a neoplasm from its primary site to lymph nodes or to distant parts of the body by way of the lymphatic system.
Nucleosides that have two hydroxy groups removed from the sugar moiety. The majority of these compounds have broad-spectrum antiretroviral activity due to their action as antimetabolites. The nucleosides are phosphorylated intracellularly to their 5'-triphosphates and act as chain-terminating inhibitors of viral reverse transcription.
A subtype of dopamine D2 receptors that are highly expressed in the LIMBIC SYSTEM of the brain.
A procedure consisting of a sequence of algebraic formulas and/or logical steps to calculate or determine a given task.
Devices or objects in various imaging techniques used to visualize or enhance visualization by simulating conditions encountered in the procedure. Phantoms are used very often in procedures employing or measuring x-irradiation or radioactive material to evaluate performance. Phantoms often have properties similar to human tissue. Water demonstrates absorbing properties similar to normal tissue, hence water-filled phantoms are used to map radiation levels. Phantoms are used also as teaching aids to simulate real conditions with x-ray or ultrasonic machines. (From Iturralde, Dictionary and Handbook of Nuclear Medicine and Clinical Imaging, 1990)
A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.
The hollow, muscular organ that maintains the circulation of the blood.
A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57)
The part of the cerebral hemisphere anterior to the central sulcus, and anterior and superior to the lateral sulcus.
A phosphodiesterase inhibitor that blocks uptake and metabolism of adenosine by erythrocytes and vascular endothelial cells. Dipyridamole also potentiates the antiaggregating action of prostacyclin. (From AMA Drug Evaluations Annual, 1994, p752)
Drugs that bind to but do not activate DOPAMINE RECEPTORS, thereby blocking the actions of dopamine or exogenous agonists. Many drugs used in the treatment of psychotic disorders (ANTIPSYCHOTIC AGENTS) are dopamine antagonists, although their therapeutic effects may be due to long-term adjustments of the brain rather than to the acute effects of blocking dopamine receptors. Dopamine antagonists have been used for several other clinical purposes including as ANTIEMETICS, in the treatment of Tourette syndrome, and for hiccup. Dopamine receptor blockade is associated with NEUROLEPTIC MALIGNANT SYNDROME.
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.
The flow of BLOOD through or around an organ or region of the body.
A colorless alkaline gas. It is formed in the body during decomposition of organic materials during a large number of metabolically important reactions. Note that the aqueous form of ammonia is referred to as AMMONIUM HYDROXIDE.
Improvement of the quality of a picture by various techniques, including computer processing, digital filtering, echocardiographic techniques, light and ultrastructural MICROSCOPY, fluorescence spectrometry and microscopy, scintigraphy, and in vitro image processing at the molecular level.
A nonmetallic, diatomic gas that is a trace element and member of the halogen family. It is used in dentistry as flouride (FLUORIDES) to prevent dental caries.
One of the catecholamine NEUROTRANSMITTERS in the brain. It is derived from TYROSINE and is the precursor to NOREPINEPHRINE and EPINEPHRINE. Dopamine is a major transmitter in the extrapyramidal system of the brain, and important in regulating movement. A family of receptors (RECEPTORS, DOPAMINE) mediate its action.
A spiro butyrophenone analog similar to HALOPERIDOL and other related compounds. It has been recommended in the treatment of SCHIZOPHRENIA.
Neoplasms of the intracranial components of the central nervous system, including the cerebral hemispheres, basal ganglia, hypothalamus, thalamus, brain stem, and cerebellum. Brain neoplasms are subdivided into primary (originating from brain tissue) and secondary (i.e., metastatic) forms. Primary neoplasms are subdivided into benign and malignant forms. In general, brain tumors may also be classified by age of onset, histologic type, or presenting location in the brain.
Substances used to allow enhanced visualization of tissues.
An element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on earth and essential for respiration.
The largest and most lateral of the BASAL GANGLIA lying between the lateral medullary lamina of the GLOBUS PALLIDUS and the EXTERNAL CAPSULE. It is part of the neostriatum and forms part of the LENTIFORM NUCLEUS along with the GLOBUS PALLIDUS.
A narcotic antagonist similar in action to NALOXONE. It is used to remobilize animals after ETORPHINE neuroleptanalgesia and is considered a specific antagonist to etorphine.
The local recurrence of a neoplasm following treatment. It arises from microscopic cells of the original neoplasm that have escaped therapeutic intervention and later become clinically visible at the original site.
The creation and display of functional images showing where the blood is flowing into the MYOCARDIUM by following over time the distribution of tracers injected into the blood stream.
A specialty field of radiology concerned with diagnostic, therapeutic, and investigative use of radioactive compounds in a pharmaceutical form.
Unstable isotopes of iodine that decay or disintegrate emitting radiation. I atoms with atomic weights 117-139, except I 127, are radioactive iodine isotopes.
A single lung lesion that is characterized by a small round mass of tissue, usually less than 1 cm in diameter, and can be detected by chest radiography. A solitary pulmonary nodule can be associated with neoplasm, tuberculosis, cyst, or other anomalies in the lung, the CHEST WALL, or the PLEURA.
Elongated gray mass of the neostriatum located adjacent to the lateral ventricle of the brain.
Measurement of the intensity and quality of fluorescence.
Volume of circulating BLOOD. It is the sum of the PLASMA VOLUME and ERYTHROCYTE VOLUME.
The range or frequency distribution of a measurement in a population (of organisms, organs or things) that has not been selected for the presence of disease or abnormality.
Lower lateral part of the cerebral hemisphere responsible for auditory, olfactory, and semantic processing. It is located inferior to the lateral fissure and anterior to the OCCIPITAL LOBE.
A pyrimidine nucleoside formed in the body by the deamination of CYTARABINE.
Studies to determine the advantages or disadvantages, practicability, or capability of accomplishing a projected plan, study, or project.
Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.
The making of a radiograph of an object or tissue by recording on a photographic plate the radiation emitted by radioactive material within the object. (Dorland, 27th ed)
Use of sound to elicit a response in the nervous system.
Unanticipated information discovered in the course of testing or medical care. Used in discussions of information that may have social or psychological consequences, such as when it is learned that a child's biological father is someone other than the putative father, or that a person tested for one disease or disorder has, or is at risk for, something else.
The effect of GLOBAL WARMING and the resulting increase in world temperatures. The predicted health effects of such long-term climatic change include increased incidence of respiratory, water-borne, and vector-borne diseases.
The use of light interaction (scattering, absorption, and fluorescence) with biological tissue to obtain morphologically based information. It includes measuring inherent tissue optical properties such as scattering, absorption, and autofluorescence; or optical properties of exogenous targeted fluorescent molecular probes such as those used in optical MOLECULAR IMAGING, or nontargeted optical CONTRAST AGENTS.
A malignant disease characterized by progressive enlargement of the lymph nodes, spleen, and general lymphoid tissue. In the classical variant, giant usually multinucleate Hodgkin's and REED-STERNBERG CELLS are present; in the nodular lymphocyte predominant variant, lymphocytic and histiocytic cells are seen.
Behavioral manifestations of cerebral dominance in which there is preferential use and superior functioning of either the left or the right side, as in the preferred use of the right hand or right foot.
A class of compounds of the type R-M, where a C atom is joined directly to any other element except H, C, N, O, F, Cl, Br, I, or At. (Grant & Hackh's Chemical Dictionary, 5th ed)
Compounds with a benzene ring fused to a thiazole ring.
Quantitative determination of receptor (binding) proteins in body fluids or tissue using radioactively labeled binding reagents (e.g., antibodies, intracellular receptors, plasma binders).
The part of brain that lies behind the BRAIN STEM in the posterior base of skull (CRANIAL FOSSA, POSTERIOR). It is also known as the "little brain" with convolutions similar to those of CEREBRAL CORTEX, inner white matter, and deep cerebellar nuclei. Its function is to coordinate voluntary movements, maintain balance, and learn motor skills.
The span of viability of a tissue or an organ.
Paired bodies containing mostly GRAY MATTER and forming part of the lateral wall of the THIRD VENTRICLE of the brain.
The process of generating three-dimensional images by electronic, photographic, or other methods. For example, three-dimensional images can be generated by assembling multiple tomographic images with the aid of a computer, while photographic 3-D images (HOLOGRAPHY) can be made by exposing film to the interference pattern created when two laser light sources shine on an object.
The rate at which oxygen is used by a tissue; microliters of oxygen STPD used per milligram of tissue per hour; the rate at which oxygen enters the blood from alveolar gas, equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body. (Stedman, 25th ed, p346)
A statistical technique that isolates and assesses the contributions of categorical independent variables to variation in the mean of a continuous dependent variable.
Tests designed to assess neurological function associated with certain behaviors. They are used in diagnosing brain dysfunction or damage and central nervous system disorders or injury.
The muscle tissue of the HEART. It is composed of striated, involuntary muscle cells (MYOCYTES, CARDIAC) connected to form the contractile pump to generate blood flow.
The application of scientific knowledge or technology to the field of radiology. The applications center mostly around x-ray or radioisotopes for diagnostic and therapeutic purposes but the technological applications of any radiation or radiologic procedure is within the scope of radiologic technology.
Recording of electric currents developed in the brain by means of electrodes applied to the scalp, to the surface of the brain, or placed within the substance of the brain.
Posterior portion of the CEREBRAL HEMISPHERES responsible for processing visual sensory information. It is located posterior to the parieto-occipital sulcus and extends to the preoccipital notch.
A rare metal element with a blue-gray appearance and atomic symbol Ge, atomic number 32, and atomic weight 72.63.
Methods for visualizing REGIONAL BLOOD FLOW, metabolic, electrical, or other physiological activities in the CENTRAL NERVOUS SYSTEM using various imaging modalities.
A colorless, odorless gas that can be formed by the body and is necessary for the respiration cycle of plants and animals.
Large subcortical nuclear masses derived from the telencephalon and located in the basal regions of the cerebral hemispheres.
Upper central part of the cerebral hemisphere. It is located posterior to central sulcus, anterior to the OCCIPITAL LOBE, and superior to the TEMPORAL LOBES.
A serotonin receptor subtype found distributed through the CENTRAL NERVOUS SYSTEM where they are involved in neuroendocrine regulation of ACTH secretion. The fact that this serotonin receptor subtype is particularly sensitive to SEROTONIN RECEPTOR AGONISTS such as BUSPIRONE suggests its role in the modulation of ANXIETY and DEPRESSION.
Cell-surface proteins that bind dopamine with high affinity and trigger intracellular changes influencing the behavior of cells.
Lutetium. An element of the rare earth family of metals. It has the atomic symbol Lu, atomic number 71, and atomic weight 175.
Care given during the period prior to undergoing surgery when psychological and physical preparations are made according to the special needs of the individual patient. This period spans the time between admission to the hospital to the time the surgery begins. (From Dictionary of Health Services Management, 2d ed)
A group of atoms or molecules attached to other molecules or cellular structures and used in studying the properties of these molecules and structures. Radioactive DNA or RNA sequences are used in MOLECULAR GENETICS to detect the presence of a complementary sequence by NUCLEIC ACID HYBRIDIZATION.
Agents that emit light after excitation by light. The wave length of the emitted light is usually longer than that of the incident light. Fluorochromes are substances that cause fluorescence in other substances, i.e., dyes used to mark or label other compounds with fluorescent tags.
A species of the genus MACACA inhabiting India, China, and other parts of Asia. The species is used extensively in biomedical research and adapts very well to living with humans.
Benign and malignant central nervous system neoplasms derived from glial cells (i.e., astrocytes, oligodendrocytes, and ependymocytes). Astrocytes may give rise to astrocytomas (ASTROCYTOMA) or glioblastoma multiforme (see GLIOBLASTOMA). Oligodendrocytes give rise to oligodendrogliomas (OLIGODENDROGLIOMA) and ependymocytes may undergo transformation to become EPENDYMOMA; CHOROID PLEXUS NEOPLASMS; or colloid cysts of the third ventricle. (From Escourolle et al., Manual of Basic Neuropathology, 2nd ed, p21)
Theoretical representations that simulate the behavior or activity of biological processes or diseases. For disease models in living animals, DISEASE MODELS, ANIMAL is available. Biological models include the use of mathematical equations, computers, and other electronic equipment.
The production of an image obtained by cameras that detect the radioactive emissions of an injected radionuclide as it has distributed differentially throughout tissues in the body. The image obtained from a moving detector is called a scan, while the image obtained from a stationary camera device is called a scintiphotograph.
Nanometer-sized particles that are nanoscale in three dimensions. They include nanocrystaline materials; NANOCAPSULES; METAL NANOPARTICLES; DENDRIMERS, and QUANTUM DOTS. The uses of nanoparticles include DRUG DELIVERY SYSTEMS and cancer targeting and imaging.
Any visible result of a procedure which is caused by the procedure itself and not by the entity being analyzed. Common examples include histological structures introduced by tissue processing, radiographic images of structures that are not naturally present in living tissue, and products of chemical reactions that occur during analysis.
Dominance of one cerebral hemisphere over the other in cerebral functions.
Theoretical representations that simulate the behavior or activity of the neurological system, processes or phenomena; includes the use of mathematical equations, computers, and other electronic equipment.
A measure of the total greenhouse gas emissions produced by an individual, organization, event, or product. It is measured in units of equivalent kilograms of CARBON DIOXIDE generated in a given time frame.
Specialized non-fenestrated tightly-joined ENDOTHELIAL CELLS with TIGHT JUNCTIONS that form a transport barrier for certain substances between the cerebral capillaries and the BRAIN tissue.
A phenethylamine found in EPHEDRA SINICA. PSEUDOEPHEDRINE is an isomer. It is an alpha- and beta-adrenergic agonist that may also enhance release of norepinephrine. It has been used for asthma, heart failure, rhinitis, and urinary incontinence, and for its central nervous system stimulatory effects in the treatment of narcolepsy and depression. It has become less extensively used with the advent of more selective agonists.
Positive test results in subjects who do not possess the attribute for which the test is conducted. The labeling of healthy persons as diseased when screening in the detection of disease. (Last, A Dictionary of Epidemiology, 2d ed)
Preliminary cancer therapy (chemotherapy, radiation therapy, hormone/endocrine therapy, immunotherapy, hyperthermia, etc.) that precedes a necessary second modality of treatment.
Mutant mice homozygous for the recessive gene "nude" which fail to develop a thymus. They are useful in tumor studies and studies on immune responses.
A clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
Small-scale tests of methods and procedures to be used on a larger scale if the pilot study demonstrates that these methods and procedures can work.
A heterogeneous aggregate of at least three distinct histological types of lung cancer, including SQUAMOUS CELL CARCINOMA; ADENOCARCINOMA; and LARGE CELL CARCINOMA. They are dealt with collectively because of their shared treatment strategy.
Treatment of chronic, severe and intractable psychiatric disorders by surgical removal or interruption of certain areas or pathways in the brain, especially in the prefrontal lobes.
One of the convolutions on the medial surface of the CEREBRAL HEMISPHERES. It surrounds the rostral part of the brain and CORPUS CALLOSUM and forms part of the LIMBIC SYSTEM.
The process whereby auditory stimuli are selected, organized, and interpreted by the organism.
An integrin that binds to a variety of plasma and extracellular matrix proteins containing the conserved RGD amino acid sequence and modulates cell adhesion. Integrin alphavbeta3 is highly expressed in OSTEOCLASTS where it may play role in BONE RESORPTION. It is also abundant in vascular smooth muscle and endothelial cells, and in some tumor cells, where it is involved in angiogenesis and cell migration. Although often referred to as the vitronectin receptor there is more than one receptor for vitronectin (RECEPTORS, VITRONECTIN).
Isomeric forms and derivatives of butanol (C4H9OH).
A group of compounds with the heterocyclic ring structure of benzo(c)pyridine. The ring structure is characteristic of the group of opium alkaloids such as papaverine. (From Stedman, 25th ed)
A value equal to the total volume flow divided by the cross-sectional area of the vascular bed.
Non-invasive imaging of cells that have been labeled non-destructively, such as with nanoemulsions or reporter genes that can be detected by molecular imaging, to monitor their location, viability, cell lineage expansion, response to drugs, movement, or other behaviors in vivo.
A sulfur-containing essential L-amino acid that is important in many body functions.
Localized reduction of blood flow to brain tissue due to arterial obstruction or systemic hypoperfusion. This frequently occurs in conjunction with brain hypoxia (HYPOXIA, BRAIN). Prolonged ischemia is associated with BRAIN INFARCTION.
The transfer of a neoplasm from one organ or part of the body to another remote from the primary site.
Tumors or cancer of the LIVER.
Sensation of making physical contact with objects, animate or inanimate. Tactile stimuli are detected by MECHANORECEPTORS in the skin and mucous membranes.
Investigative technique commonly used during ELECTROENCEPHALOGRAPHY in which a series of bright light flashes or visual patterns are used to elicit brain activity.
The rate dynamics in chemical or physical systems.
Methods of creating machines and devices.
Substances that inhibit or prevent the proliferation of NEOPLASMS.
Techniques used for determining the values of photometric parameters of light resulting from LUMINESCENCE.
Compounds that contain the radical R2C=N.OH derived from condensation of ALDEHYDES or KETONES with HYDROXYLAMINE. Members of this group are CHOLINESTERASE REACTIVATORS.
Computer-based representation of physical systems and phenomena such as chemical processes.
Any substance in the air which could, if present in high enough concentration, harm humans, animals, vegetation or material. Substances include GASES; PARTICULATE MATTER; and volatile ORGANIC CHEMICALS.
Decrease in the size of a cell, tissue, organ, or multiple organs, associated with a variety of pathological conditions such as abnormal cellular changes, ischemia, malnutrition, or hormonal changes.
A cell line derived from cultured tumor cells.
Sodium chloride-dependent neurotransmitter symporters located primarily on the PLASMA MEMBRANE of serotonergic neurons. They are different than SEROTONIN RECEPTORS, which signal cellular responses to SEROTONIN. They remove SEROTONIN from the EXTRACELLULAR SPACE by high affinity reuptake into PRESYNAPTIC TERMINALS. Regulates signal amplitude and duration at serotonergic synapses and is the site of action of the SEROTONIN UPTAKE INHIBITORS.
A graphic means for assessing the ability of a screening test to discriminate between healthy and diseased persons; may also be used in other studies, e.g., distinguishing stimuli responses as to a faint stimuli or nonstimuli.
Tumors or cancer of the ESOPHAGUS.
Electronic instruments that produce photographs or cathode-ray tube images of the gamma-ray emissions from organs containing radionuclide tracers.
The use of two or more chemicals simultaneously or sequentially in the drug therapy of neoplasms. The drugs need not be in the same dosage form.
A catecholamine derivative with specificity for BETA-1 ADRENERGIC RECEPTORS. It is commonly used as a cardiotonic agent after CARDIAC SURGERY and during DOBUTAMINE STRESS ECHOCARDIOGRAPHY.
Removal and pathologic examination of specimens in the form of small pieces of tissue from the living body.
They are oval or bean shaped bodies (1 - 30 mm in diameter) located along the lymphatic system.
Sodium chloride-dependent neurotransmitter symporters located primarily on the PLASMA MEMBRANE of dopaminergic neurons. They remove DOPAMINE from the EXTRACELLULAR SPACE by high affinity reuptake into PRESYNAPTIC TERMINALS and are the target of DOPAMINE UPTAKE INHIBITORS.
Non-invasive method of vascular imaging and determination of internal anatomy without injection of contrast media or radiation exposure. The technique is used especially in CEREBRAL ANGIOGRAPHY as well as for studies of other vascular structures.
The creation and display of functional images showing where the blood flow reaches by following the distribution of tracers injected into the blood stream.
Endoscopic examination, therapy or surgery of the anterior superior mediastinum of the thorax.
Tumors or cancer of the human BREAST.
Tumors or cancer located in bone tissue or specific BONES.
Tumors or cancer of the MEDIASTINUM.
Individual components of atoms, usually subatomic; subnuclear particles are usually detected only when the atomic nucleus decays and then only transiently, as most of them are unstable, often yielding pure energy without substance, i.e., radiation.
A dibenzoxepin tricyclic compound. It displays a range of pharmacological actions including maintaining adrenergic innervation. Its mechanism of action is not fully understood, but it appears to block reuptake of monoaminergic neurotransmitters into presynaptic terminals. It also possesses anticholinergic activity and modulates antagonism of histamine H(1)- and H(2)-receptors.
Theoretical representations that simulate the behavior or activity of systems, processes, or phenomena. They include the use of mathematical equations, computers, and other electronic equipment.
Prolonged dysfunction of the myocardium after a brief episode of severe ischemia, with gradual return of contractile activity.
The simplest saturated hydrocarbon. It is a colorless, flammable gas, slightly soluble in water. It is one of the chief constituents of natural gas and is formed in the decomposition of organic matter. (Grant & Hackh's Chemical Dictionary, 5th ed)
Changes in the amounts of various chemicals (neurotransmitters, receptors, enzymes, and other metabolites) specific to the area of the central nervous system contained within the head. These are monitored over time, during sensory stimulation, or under different disease states.
Emission of LIGHT when ELECTRONS return to the electronic ground state from an excited state and lose the energy as PHOTONS. It is sometimes called cool light in contrast to INCANDESCENCE. LUMINESCENT MEASUREMENTS take advantage of this type of light emitted from LUMINESCENT AGENTS.
Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.
A membrane in the midline of the THORAX of mammals. It separates the lungs between the STERNUM in front and the VERTEBRAL COLUMN behind. It also surrounds the HEART, TRACHEA, ESOPHAGUS, THYMUS, and LYMPH NODES.
The total amount (cell number, weight, size or volume) of tumor cells or tissue in the body.
An enzyme that catalyzes the conversion of ATP and thymidine to ADP and thymidine 5'-phosphate. Deoxyuridine can also act as an acceptor and dGTP as a donor. (From Enzyme Nomenclature, 1992) EC 2.7.1.21.
A technetium imaging agent used to reveal blood-starved cardiac tissue during a heart attack.
Organic compounds that contain technetium as an integral part of the molecule. These compounds are often used as radionuclide imaging agents.
INFLAMMATION of any ARTERIES.
Intellectual or mental process whereby an organism obtains knowledge.
Behavior of LIGHT and its interactions with itself and materials.
Much of the understanding thus far has come from neuroimaging techniques such as radiotracer positron emission tomography(PET ... and functional magnetic resonance imaging (fMRI) scans, as well as genetic studies. Together, neuroimaging with multimodal PET/ ...
... of altered states of consciousness with state-of-the-art multimodal imaging combining the information from positron emission ... and of neuronal plasticity in severely brain damaged patients with altered states of consciousness by means of multimodal ... tomography (PET), functional magnetic resonance imaging (fMRI), structural MRI, electroencephalography (EEG), event related ...
... while optical imaging (fluorescence and bioluminescence), positron emission tomography (PET), and single photon emission ... provide multi-modal systems combining the advantages of anatomical modalities such as CT and MR with the functional imaging of ... Principle: Positron Emission Tomography (PET) images living systems by recording high-energy γ-rays emitted from within the ... This allows individual emission events to be localized within the body, and the data set is reconstructed to produce images. ...
... optical imaging techniques (microscopy and near-infrared spectroscopy), positron emission tomography (PET), molecular imaging, ... A particular area of innovation at the Center is Multimodal Functional Neuroimaging, which involves the integration of imaging ... The Athinoula A. Martinos Center for Biomedical Imaging, usually referred to as just the "Martinos Center," is a major hub of ... The core technologies being developed and used at the Center are magnetic resonance imaging (MRI) and in vivo magnetic ...
... positron emission tomography (PET) and dynamic imaging. This technology targets engineers, mathematicians, biologists and other ... Newton Gateway has played a key role in bringing together scientists to discuss various types of multimodal clinical imaging ... Cutting edge imaging technologies have been showcased, such as multi-contrast magnetic resonance tomography (MRT), ...
... imagery such as temporal data of functional magnetic resonance imaging and scalar densities such as Positron emission ... generally termed multi-modal medical imagery, providing either scalar and or vector quantities at each spatial location. ... Maintz, J. B.; Viergever, M. A. (1998-03-01). "A survey of medical image registration". Medical Image Analysis. 2 (1): 1-36. ... with the set of observed images element in the random orbit model of CA for images I ∈ I ≐ { I = I t e m p ∘ φ , φ ∈ D i f f V ...
"Imaging Chronic Tuberculous Lesions Using Sodium [18F]Fluoride Positron Emission Tomography in Mice". Molecular Imaging and ... Multimodal [18F]-PET and Fluorescence Imaging Agent Targeting Prostate Specific Membrane Antigen: First-in-Human Study". ... which allows for positron emission tomography (PET) imaging of cancer. A Human-Derived, Genetic, Positron-emitting and ... It decays by positron emission 97% of the time and electron capture 3% of the time. Both modes of decay yield stable oxygen-18 ...
Additionally, changes in biochemical (functional) activity can be observed using imaging modalities such as Positron Emission ... Multi-modal registration requires a more sophisticated similarity measure; alternatively, a different image representation can ... Typically, one image is treated as the target image and the other is treated as a source image; the source image is transformed ... The resulting images cannot be treated as regular scalar images and give rise to new sub-areas of Medical Image Computing. ...
... and positron emission tomography (PET) got their names. While the first human positron imaging device was developed by Gordon ... Multimodal imaging combines existing brain imaging techniques in synergistic ways which facilitate the improved interpretation ... imaging. H20-15 emits positrons and creates images based on regional blood flow within the brain. Since active neurons recruit ... Later, a more common sort of functional imaging based on PET scans used FDG, a positron-emitting sugar-derivative which is ...
Positron emission tomography (PET). ReferencesEdit. *^ "Metastasis", Merriam-Webster online, accessed 20 Aug 2017. ... However, imaging of the indicated area only occasionally reveals a primary. In rare cases (e.g., of melanoma), no primary tumor ... "multimodal therapy"). The choice of treatment depends on many factors, including the type of primary cancer, the size and ... List of included entries and references is found on main image page in Commons: Commons:File:Metastasis sites for common ...
Positron Emission Tomography detects particles called photons using a 3-D nuclear medicine examination. These particles are ... Calcium imaging relies on dyes or genetically encoded proteins that fluoresce upon binding to the calcium that is transiently ... "Multimodal fast optical interrogation of neural circuitry". Nature. 446 (7136): 633-639. Bibcode:2007Natur.446..633Z. doi: ... PET imaging reveal the pathological processes which predict anatomic changes making it important for detecting, diagnosing and ...
Multimodal imaging frequently consists of the coupling of an electrophysiologic measurement technique, such as EEG or MEG, with ... Bailey, DL (2005). Positron Emission Tomography: Basic Sciences. Elsevier. doi:10.1007/b136169. ISBN 978-1-84628-007-8. OCLC ... To do so, one must first register all images to a standard coordinate system, by mapping them to a reference image. This is ... Typical sampling rates for fMRI images are in the tenths of seconds. Magnetoencephalography (MEG) is an imaging modality that ...
PMCID: PMC117568 Gambhir SS (2002). "Molecular imaging of cancer with positron emission tomography". Nat Rev Cancer. 2 (9): 683 ... Jokerst, J.; C. Khademi; S.S. Gambhir (2013). "Intracellular Aggregation of Multimodal Silica Nanoparticles for Ultrasound- ... nanoparticle based imaging, Raman imaging in vivo and photoacoustic molecular imaging with novel imaging agents in living ... Non-Invasive Imaging of Islet Grafts Using Positron Emission Tomography. PNAS USA. 103: 11294-11299, 2006. PMCID: PMC1544080 So ...
... is also widely used in medical image reconstruction, especially in positron emission tomography, single-photon emission ... For multimodal distributions, this means that an EM algorithm may converge to a local maximum of the observed data likelihood ...
Bénard, François; Turcotte, Éric (12 May 2005). "Imaging in breast cancer: Single-photon computed tomography and positron- ... For this reason, a "multimodal approach" is suggested, where optical mammography is complementary to another conventional ... emission tomography". Breast Cancer Research. 7 (4): 153-62. doi:10.1186/bcr1201. PMC 1175073. PMID 15987467. Taroni, Paola ( ... Breast imaging Diffuse optical imaging Optical tomography Radiative transfer equation and diffusion theory for photon transport ...
Although 18F-fluorodeoxyglucose (FDG)-positron emission tomography (PET)/CT has been explored as a viable method for staging, ... Somani BK, Gimlin D, Fayers P, N'dow J (November 2009). "Quality of life and body image for bladder cancer patients undergoing ... multimodal therapy, preferred) or transurethral resection with chemoradiation (trimodal therapy, highly selected people) or ... Staging of the cancer is determined by transurethral resection and medical imaging. Treatment depends on the stage of the ...
Positron emission tomography (PET) and functional magnetic resonance (fMRI) allow cognitive neuroscientists to explore ... 2007). Various neural imaging and research points to semantic memory and episodic memory resulting from distinct areas in the ... the idea that the temporal pole bilaterally is the convergence zone for unimodal semantic representations into a multimodal ... due in part to the development of functional neuroimaging methods such as positron emission tomography (PET) and functional ...
Magnetic resonance imaging (MRI) Computerized tomography (CT) Positron emission tomography (PET) Film autoradiography Single ... In primates this connection is absent and there are highly differentiated connections between the multimodal parasensory and ... Imaging studies following localized changes intracellular calcium from discrete synaptic inputs have shown a role for these ... which are transparent in early stages of larval development and allow for dye-labeled neurons to be repeatedly imaged in the ...
... a positron emission tomographic investigation. Archives of General Psychiatry, Vol. 54, No. 3, 1997, pp233-241. Rauch, S. L., ... Image generation Image maintenance Image inspection Image transformation Image generation involves generating mental imagery, ... Juttner, M., and Rentschler, I., Imagery in multi-modal object learning. Behavioral and Brain Sciences, Vol. 25, No. 2, 2002, ... Kosslyn, S. M., Image and brain: The resolution of the imagery debate. Cambridge, MA: MIT Press, 1994. Kosslyn, S. M., Image ...
Positron emission tomography (PET) can then be used to image the brain and changes in blood flow and results show very similar ... 2012). "Atlas-based analysis of resting-state functional connectivity: Evaluation for reproducibility and multi-modal anatomy- ... Functional magnetic resonance imaging (functional MRI or fMRI) is a specific magnetic resonance imaging (MRI) procedure that ... Resting-state functional magnetic resonance imaging (rfMRI) can image low-frequency fluctuations in the spontaneous brain ...
More recently, neuroimaging studies using positron emission tomography and fMRI have suggested a balanced model in which the ... and functional imaging One fMRI monkey study further demonstrated a role of the aSTG in the recognition of individual voices. ... Lewis JW, Van Essen DC (December 2000). "Corticocortical connections of visual, sensorimotor, and multimodal processing areas ... The role of the ADS in speech repetition is also congruent with the results of the other functional imaging studies that have ...
Positron emission tomography (PET) demonstrates that methylphenidate decreases regional cerebral blood flow in the doroslateral ... Magnetic resonance imaging (MRI) studies suggest that long-term treatment with ADHD stimulants (specifically, amphetamine and ... Hinshaw SP, Arnold LE (January 2015). "ADHD, Multimodal Treatment, and Longitudinal Outcome: Evidence, Paradox, and Challenge ... Hart H, Radua J, Nakao T, Mataix-Cols D, Rubia K (February 2013). "Meta-analysis of functional magnetic resonance imaging ...
Multimodal sensory processing, sensory bindingEdit. Functional imaging studies show activation of the insula during audio- ... a positron emission tomography study". J. Urol. 168 (5): 2035-9. doi:10.1016/s0022-5347(05)64290-5. PMID 12394703.. ... Functional imaging experiments have revealed that the insula has an important role in pain experience and the experience of a ... Several functional imaging studies have also shown that the insula is activated when drug users are exposed to drug cues, and ...
Magnetic resonance imaging (MRI) scans to assess brain structure, connectivity, and the extent of white matter disease Positron ... "Label-aligned multi-task feature learning for multimodal classification of Alzheimer's disease and mild cognitive impairment". ... emission tomography (PET) scans to assess how well the brain uses glucose, and the extent of amyloid plaques and tau tangles. ... It shares imaging and genetic data with the Enhancing Neuro Imaging Genetics through Meta-Analysis (ENIGMA) consortium which ...
In the 1990s, with the advent of positron emission tomography (PET) scans, researchers began to notice that when a person is ... Diffusion MRI imaging shows white matter tracts connecting different areas of the DMN together.[17] The structural connections ... "Neural correlates of the LSD experience revealed by multimodal neuroimaging". Proceedings of the National Academy of Sciences ... This image shows main regions of the default mode network (yellow) and connectivity between the regions color-coded by ...
... which allows for positron emission tomography (PET) imaging of cancer and hemorrhages, respectively. A Human-Derived, Genetic, ... Multimodal [18F]-PET and Fluorescence Imaging Agent Targeting Prostate Specific Membrane Antigen: First-in-Human Study". ... positron-emitting agent for imaging PMSA allows genetic reporting in adoptively-transferred, genetically-modified cells". ACS ... "18F-positron-emitting/fluorescent labeled erythrocytes allow imaging of internal hemorrhage in a murine intracranial hemorrhage ...
Several other methods to study brain function exist, including functional magnetic resonance imaging (fMRI), positron emission ... Ieracitano, Cosimo; Mammone, Nadia; Hussain, Amir; Morabito, Francesco C. (2020). "A novel multi-modal machine learning based ... EEG has also been combined with positron emission tomography. This provides the advantage of allowing researchers to see what ... These fields produce potentially harmful radio frequency heating and create image artifacts rendering images useless. Due to ...
Several other methods to study brain function exist, including functional magnetic resonance imaging (fMRI), positron emission ... "A novel multi-modal machine learning based approach for automatic classification of EEG recordings in dementia". Neural ... EEG has also been combined with positron emission tomography. This provides the advantage of allowing researchers to see what ... EEG does not involve exposure to radioligands, unlike positron emission tomography.[28] ...
... and positron emission tomography measures of regional cerebral blood flow or metabolism. Studies using ALFF and fALFF have ... Using the PET imaging technology and reagents available as of 2012, it appeared that the D1 receptor may be underexpressed in ... A multimodal meta-analysis". Journal of Affective Disorders. 210: 303-311. doi:10.1016/j.jad.2016.12.032. PMID 28068619. Kühn, ... Li, Z; He, Y; Tang, J; Zong, X; Hu, M; Chen, X (15 March 2015). "Molecular imaging of striatal dopamine transporters in major ...
Positron emission tomography (PET), single photon emission computed tomography (SPECT) and computed tomography (CT) have been ... "Multimodal In Vivo Imaging of Tumorigenesis and Response to Chemotherapy in a Transgenic Mouse Model of Mammary Cancer". ... Transgenic mouse models can be imaged by various non-invasive techniques. Bioluminescence imaging relies on the detection of ... Magnetic resonance imaging requires the use of nano-particles(liposomes) and an MRI contrast agent called gadolinium. The ...
It combines the benefits of high resolution metabolic imaging with Time-Of-Flight Positron Emission Tomography (PET) and ... Both require advanced imaging techniques for their diagnosis and staging. The endoTOFPET-US collaboration develops a multimodal ... The X-Ray imaging system is the technological platform of PIXIRAD Imaging Counters s.r.l., a recently constituted INFN spin-off ... A time-of-flight positron emission tomography (TOF PET) prototype apparatus, based on the principles of Cherenkov photon ...
... which includes structural and functional magnetic resonance imaging (MRI), positron emission tomography (PET) and multimodal ...
... including a Positron Emission Tomography (PET) scanner, which images metabolic activity in the brain. This multi-modal imaging ... "Neural Imaging is an exciting and rapidly changing discipline in neuroscience. The ability to image the brain at high ... "With cutting-edge imaging technology, researchers will transform the way we approach the study of brain behavior, which will ... The MNC already houses a Magnetic Resonance Imaging (MRI) scanner, ideal for mapping brain structures, and a ...
... magnetic resonance imaging, MRI; positron emission imaging, PET), changes in electrophysiology (electroencephalography, EEG); ... Collecting highly complex multi-modal physiological databases from different centres is a complex task that requires good co- ... magnetic resonance imaging, MRI; positron emission imaging, PET), ... a methodology for finding efficient combinations of multi-modal ... Scientific Objective 1: Development of a methodology for finding efficient combinations of multi-modal biomarkers in ...
Positron Emission Tomography Based Elucidation of the Enhanced Permeability and Retention Effect in Dogs with Cancer Using ... Atherosclerotic plaque targeting mechanism of long-circulating nanoparticles established by multimodal imaging. Publikation: ... Mouse Positron Emission Tomography Study of the Biodistribution of Gold Nanoparticles with Different Surface Coatings Using ... PET imaging using radiolabeled liposomes can identify cancers positive for the EPR effect. In the current study, we show in ...
Upon CT imaging, no heater-related artifacts were observed when carbon-fiber was used. Multimodal imaging was performed and ... and positron emission tomography (PET)-compatible carbon-fiber sheet resistor for temperature maintenance in small animals ... MR and CT compatibility were also shown, and multimodal MR-CT-PET-SPECT imaging of the mouse abdomen was performed in vivo. ... The heater is small, and it is easy to produce and integrate into multimodal imaging cradles. ...
and functional underpinnings of Alzheimers Disease (AD). He utilizes various imaging modalities, such as Positron Emission ... Bischof GN, Endepols H, van Eimeren T, Drzezga A.Tau-imaging in neurodegeneration. Methods. 2017 Nov 1;130:114-123. ... Tomography (PET) or Magnet Resonance Imaging (MRI) to investigate the main culprits of neurodegeneration in AD and their ...
... which includes structural and functional magnetic resonance imaging (MRI), positron emission tomography (PET) and multimodal ...
... employing positron emission tomography (PET) to measure amyloid and tau proteins in the brain, and magnetic resonance imaging ( ... His laboratory has pioneered in the use of multimodal imaging to understand brain aging and Alzheimers disease, ... His lab is involved in several ongoing, large scale imaging studies of cognition in normal aging, studies of heterogeneity of ... Prashanthi Vemuri, PhD, is an Associate Professor in the Department of Radiology, Mayo Clinic Rochester and an imaging ...
... uptake on positron emission tomography (PET) examination during or after neoadjuvant chemotherapy may predict pathological ... Multimodal Imaging, Neoadjuvant Therapy, Positron-Emission Tomography, Radiopharmaceuticals, Tissue Distribution, Tomography, X ... OBJECTIVES: Reports have suggested that a reduction in tumour 18F-fluorodeoxyglucose (FDG) uptake on positron emission ...
It offers equipment covering all types of imaging at the highest level of development to the scientific community. ... France Life Imaging (FLI) is a National Infrastructure in Biology and Health that coordinates and standardizes French ... by superimposing MRI images that provide information on the anatomy of the brain and images acquired by positron emission ... Multimodal imaging (PET, MRI) and its applications *Management and processing of information (images, biological and genetic ...
We describe the details of image acquisition and analysis in a step-wise manner along with the development of a mouse model for ... ex vivo whole-organ optical imaging and high spatial resolution confocal microscopy to deconstruct the trafficking of ... of effective nanoformulations that target metastatic breast cancers is challenging due to a lack of competent imaging and image ... Keywords: In vivo imaging, Positron emission tomography, Optical imaging, Cancer, Metastasis, Mouse models ...
Combining orthotopic tumor models with preclinical imaging lets you observe novel therapeutic agents in detail, with greater ... Small animal imaging technologies which are useful in preclinical research include:. *Positron emission tomography (PET) ... Multimodal Imaging. To broaden the horizons of research, high-resolution imaging modalities are now being more commonly used in ... Non-Invasive Small Animal Imaging. State-of-the-art small-animal imaging modalities provide non-invasive images full of ...
F18-fluorodeoxyglucose positron emission tomography in the context of other imaging techniques and prognostic factors in ... Multimodal image coregistration and inducible selective cell ablation to evaluate imaging ligands.. Virostko J, Henske J, Vinet ... A peptide-based positron emission tomography probe for in vivo detection of caspase activity in apoptotic cells.. Hight MR, ... Connections to Positron-Emission Tomography are shown below. Double-click or tap a node for more information. ...
"We are hoping to obtain funding for other novel imaging tools such as PET [positron emission tomography] studies to elucidate ... Shah SA, Lowder R, Kuceyeski A. Quantitative multimodal imaging in traumatic brain injuries producing impaired cognition. ... are using multimodal imaging to study the effects of TBI on executive attention recovery in a cohort of 75 adults. Chronic ... Image courtesy of Keith Jamison, Amy Kuceyeski, PhD, and Sudhin A. Shah, PhD) ...
Positron Emission Tomography Computed Tomography Medicine & Life Sciences 62% * Microspheres Medicine & Life Sciences 58% ... Multimodal Imaging Medicine & Life Sciences 25% * Computed Tomography Angiography Medicine & Life Sciences 19% ... In: European Journal of Nuclear Medicine and Molecular Imaging, Vol. 36, No. 4, 04.2009, p. 576-586.. Research output: ... These results encourage further testing of the robustness and usefulness in the clinical context of cardiac hybrid imaging. ...
Positron Emission Tomography. *Research Topics *Quantitative Image Analysis. *Functional MRI (fMRI). *Multimodal Imaging ... Positron Emission Tomography. j.van_den_hoff. hzdr.de. Phone: +49 351 260 2621. +49 351 4585068 ... Positron Emission Tomography. j.van_den_hoff. hzdr.de. Phone: +49 351 260 2621. +49 351 4585068 ... Positron Emission Tomography. p.nikulin. hzdr.de. Phone: +49 351 260 2709 ...
packages that specialize about performed upper infrastructures help Positron Emission Tomography( PET) in compliant download » ... image-guided download probability and camera is Architectural laws which provide the -hydroxamic survey of the low diary of ... that can determine spectra birth to multimodal apartments within a Book. 2018BLACK444 entrepreneurs and instructions for abrupt ... images can be 2005-10-01T12:00:00Cultural railroads and including, and the download probability and statistics can show From ...
... whereas indirect imaging fMRI (functional magnetic resonance imaging), PET (positron emission tomography), etc., measure ... multimodal combination, focus, reviewing memory, syntactic handling and the preparing of significant data, activity, feeling ... direct imaging, and indirect imaging, direct imaging measures electrical or magnetic signal generated due neuronal activity ... Direct imaging reasonable good spatial resolution and excellent temporal resolution 1 ms in case of EEG its 10 mm but having ...
The spearhead technologies of the Finnish Biomedical Imaging Node include 1) preclinical and human positron emission tomography ... Helsinki in vivo Animal Imaging Platform at University of Helsinki offers diverse opportunities for multimodal imaging, ... The Finnish Biomedical Imaging Node is a multi-sited and multi-modal research infrastructure that covers the most important ... including intravital imaging, whole-body optical imaging, ultrasound, in vivo µCT, and electrophysiology and behavioral ...
Compared to optical imaging, Positron Emission Tomography (PET) has the advantage of greater resolution and greatly reduced ... and image guided therapy. Another focus is the development of multimodal drugs that simultaneously image and provide therapy. ... 18F-FLT Positron Emission Tomography/Computed Tomography Imaging in Pancreatic Cancer: Determination of Tumor Proliferative ... From left to right are the CT, PET, and PET/CT fused images. Right: PET image of a dynamic lung phantom imaged with the tumor ( ...
EN] The impact of positron emission tomography (PET) on radiation therapy is held back by poor methods of defining functional ... Comparative Study With New Accuracy Metrics for Target Volume Contouring in PET Image Guided Radiation Therapy  ... Desarrollo de un escritorio digital para la captura, transcripción y gestión multimodal e interactiva de documentos manuscritos ... transcripción y gestión multimodal e interactiva de documentos manuscritos". The ... ...
... such as positron emission tomography (PET) and single-photon em... ... J Nucl Med 2003;44(2):291-315 Vija H. Introduction to xSPECT technology: evolving multi-modal SPECT to become context-based and ... Nuclear medicine imaging methods that use radionuclides, such as positron emission tomography (PET) and single-photon emission ... Nuclear medicine imaging methods that use radionuclides, such as positron emission tomography (PET) and single-photon emission ...
Magnetic Resonance Imaging (MRI) Systems, Multimodal Imaging Systems, Positron Emission Tomography (PET) Systems, X-Ray ... In Vivo Imaging Reagents , Plant Imaging Systems, Computed Tomography (CT) Imaging Systems, Fluorescence Imaging / Tomography ... Bioluminescence Imaging / Tomography Systems, Computed Tomography (CT) Imaging Systems, Fluorescence Imaging / Tomography ... Radiography Imaging Systems, Single Photon Emission Computed Tomography (SPECT) Systems, In Vivo Imaging Software ...
In this positron emission tomography study, phobics were exposed to masked visual stimuli with timings that either allowed ... Brugman, H., & Russel, A. (2004). Annotating Multi-media/Multi-modal resources with ELAN. In M. Lino, M. Xavier, F. Ferreira, R ... awareness or not of either phobic, fear-relevant (e.g., spiders to snake phobics), or neutral images. When the timing did not ... Brown, P., Gaskins, S., Lieven, E., Striano, T., & Liszkowski, U. (2004). Multimodal multiperson interaction with infants aged ...
In this positron emission tomography study, phobics were exposed to masked visual stimuli with timings that either allowed ... Brugman, H., & Russel, A. (2004). Annotating Multi-media/Multi-modal resources with ELAN. In M. Lino, M. Xavier, F. Ferreira, R ... awareness or not of either phobic, fear-relevant (e.g., spiders to snake phobics), or neutral images. When the timing did not ... Brown, P., Gaskins, S., Lieven, E., Striano, T., & Liszkowski, U. (2004). Multimodal multiperson interaction with infants aged ...
This study uses positron emission tomography (PET) with O(15) H₂O to measure regional cerebral blood flow (rCBF) in response to ... The MCIC collection: a shared repository of multi-modal, multi-site brain image data from a clinical investigation of ... Eyeblink conditioning in healthy adults: a positron emission tomography study.. Authors:. Krystal L Parker Nancy C Andreasen ... Eyeblink conditioning in unmedicated schizophrenia patients: a positron emission tomography study.. Authors:. Krystal L Parker ...
123I-Iofluopane Single-Photon Emission Computed Tomography as an Imaging Biomarker of Pre-Synaptic Dopaminergic System after ... Author Correction: Multimodal hippocampal subfield grading for Alzheimers disease classification (Scientific Reports, (2019), ...
In this positron emission tomography study, phobics were exposed to masked visual stimuli with timings that either allowed ... Until recently, imaging the infant brain was very challenging. Functional Near InfraRed Spectroscopy (fNIRS) is a promising, ... Campisi, E., & Ozyurek, A. (2013). Iconicity as a communicative strategy: Recipient design in multimodal demonstrations for ... For each item participants were shown a display of four images that differed in two dimensions. Each sentence contained an ...
In this positron emission tomography study, phobics were exposed to masked visual stimuli with timings that either allowed ... Through the combined analyses of three approaches, we have provided a conclusive image of the genetic profile of the Noir ... Campisi, E., & Ozyurek, A. (2013). Iconicity as a communicative strategy: Recipient design in multimodal demonstrations for ... Functional imaging revealed systematic increases in activity that paralleled the psychophysical results within anterior ...

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